# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- NADHdh PF00146.16 ERZ94499.1 - 6.2e-24 84.6 0.1 6.2e-24 84.6 0.1 1.6 3 0 0 3 3 3 1 NADH dehydrogenase EmrE PF13536.1 ERZ94499.1 - 0.086 13.0 8.3 0.46 10.7 2.2 2.2 2 0 0 2 2 2 0 Multidrug resistance efflux transporter DUF3925 PF13063.1 ERZ94499.1 - 0.88 9.6 6.9 0.27 11.3 2.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3925) LAGLIDADG_1 PF00961.14 ERZ94501.1 - 2.1e-22 79.5 5.3 9.9e-15 54.9 1.3 2.2 2 0 0 2 2 2 2 LAGLIDADG endonuclease COX1 PF00115.15 ERZ94502.1 - 5.1e-24 84.7 11.4 6.5e-24 84.3 7.9 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF360 PF04020.8 ERZ94502.1 - 0.18 12.1 3.8 0.29 11.5 2.6 1.5 1 1 0 1 1 1 0 Membrane protein of unknown function E1-E2_ATPase PF00122.15 ERZ94502.1 - 0.4 9.6 2.6 0.43 9.5 1.8 1.1 1 0 0 1 1 1 0 E1-E2 ATPase NapE PF06796.6 ERZ94502.1 - 4 6.8 5.5 0.82 9.0 0.7 2.0 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE LAGLIDADG_1 PF00961.14 ERZ94503.1 - 5.8e-07 30.0 0.1 9e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 LAGLIDADG endonuclease LAGLIDADG_3 PF14528.1 ERZ94503.1 - 0.0028 17.8 0.0 0.0042 17.2 0.0 1.5 1 1 0 1 1 1 1 LAGLIDADG-like domain COX1 PF00115.15 ERZ94505.1 - 2e-15 56.3 2.2 2.1e-15 56.3 1.6 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I COX1 PF00115.15 ERZ94506.1 - 0.0077 14.9 0.1 0.0085 14.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DNA_pol_B_2 PF03175.8 ERZ94507.1 - 1.9e-07 30.1 0.2 2.2e-07 29.9 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Imm10 PF15562.1 ERZ94507.1 - 0.0038 16.9 0.4 0.0086 15.8 0.0 1.8 2 0 0 2 2 2 1 Immunity protein 10 P53_C PF11619.3 ERZ94507.1 - 0.032 13.9 0.1 0.17 11.6 0.0 2.1 1 1 1 2 2 2 0 Transcription factor P53 - C terminal domain Oxidored_q2 PF00420.19 ERZ94508.1 - 6.9e-22 76.8 12.1 7.3e-22 76.7 8.4 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L XK-related PF09815.4 ERZ94508.1 - 0.24 10.3 7.1 0.26 10.2 4.9 1.1 1 0 0 1 1 1 0 XK-related protein DUF843 PF05814.6 ERZ94508.1 - 8.6 6.2 9.5 13 5.6 6.6 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) NADHdh PF00146.16 ERZ94509.1 - 1.7e-80 270.4 17.2 1.9e-80 270.2 11.9 1.0 1 0 0 1 1 1 1 NADH dehydrogenase COX1 PF00115.15 ERZ94511.1 - 1.1e-33 116.5 6.8 1.4e-33 116.2 4.7 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Cytochrom_B_N PF00033.14 ERZ94511.1 - 0.03 13.6 6.5 0.32 10.3 2.2 2.1 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB DUF4386 PF14329.1 ERZ94511.1 - 0.034 13.6 1.0 0.057 12.8 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) LAGLIDADG_2 PF03161.8 ERZ94513.1 - 1.8e-46 158.2 0.1 2.1e-46 158.0 0.1 1.0 1 0 0 1 1 1 1 LAGLIDADG DNA endonuclease family DNA_pol_B_2 PF03175.8 ERZ94514.1 - 1.7e-38 132.4 0.0 2.1e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DNA_pol_B PF00136.16 ERZ94514.1 - 2.8e-06 26.3 0.0 0.0062 15.3 0.0 3.0 3 0 0 3 3 3 3 DNA polymerase family B DNA_pol_B PF00136.16 ERZ94516.1 - 0.0003 19.7 0.0 0.00031 19.6 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B MscS_porin PF12795.2 ERZ94517.1 - 0.0081 15.5 0.9 0.0099 15.2 0.6 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain TBPIP PF07106.8 ERZ94517.1 - 0.035 13.6 0.1 0.05 13.1 0.1 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Cluap1 PF10234.4 ERZ94517.1 - 0.043 13.0 0.1 0.046 12.9 0.1 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 Prefoldin_2 PF01920.15 ERZ94517.1 - 0.054 13.2 0.2 0.085 12.6 0.1 1.2 1 0 0 1 1 1 0 Prefoldin subunit CASP_C PF08172.7 ERZ94517.1 - 0.06 12.3 1.6 0.083 11.9 1.1 1.2 1 0 0 1 1 1 0 CASP C terminal Muted PF14942.1 ERZ94517.1 - 0.075 12.9 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein MbeD_MobD PF04899.7 ERZ94517.1 - 0.077 12.9 1.9 0.75 9.7 0.1 2.1 1 1 1 2 2 2 0 MbeD/MobD like Prominin PF05478.6 ERZ94517.1 - 0.077 10.5 0.4 0.09 10.2 0.3 1.1 1 0 0 1 1 1 0 Prominin XhlA PF10779.4 ERZ94517.1 - 0.09 12.7 0.5 0.12 12.2 0.3 1.2 1 0 0 1 1 1 0 Haemolysin XhlA DUF3450 PF11932.3 ERZ94517.1 - 0.092 12.0 1.0 0.11 11.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) COG2 PF06148.6 ERZ94517.1 - 0.099 12.5 0.3 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 ERZ94517.1 - 0.13 12.5 3.3 0.12 12.6 1.2 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.3 ERZ94517.1 - 0.16 11.8 1.0 0.25 11.1 0.7 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DNA_pol_B PF00136.16 ERZ94518.1 - 0.0005 18.9 0.1 0.00064 18.6 0.1 1.4 1 1 0 1 1 1 1 DNA polymerase family B COX3 PF00510.13 ERZ94519.1 - 1.4e-106 355.6 19.7 1.7e-106 355.4 13.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III Oxidored_q3 PF00499.15 ERZ94520.1 - 5.1e-24 84.7 24.9 7.9e-24 84.0 17.3 1.3 1 1 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 MpPF26 PF07666.6 ERZ94520.1 - 0.023 14.5 3.3 0.023 14.5 2.3 3.1 2 1 1 3 3 3 0 M penetrans paralogue family 26 Oxidored_q1 PF00361.15 ERZ94521.1 - 5.5e-51 173.3 31.1 5.5e-51 173.3 21.6 5.2 3 2 1 4 4 4 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q4 PF00507.14 ERZ94521.1 - 8.1e-28 96.2 4.6 8.1e-28 96.2 3.2 4.8 5 1 2 7 7 7 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 LAGLIDADG_2 PF03161.8 ERZ94521.1 - 4e-08 33.3 0.1 0.001 18.9 0.0 2.5 1 1 1 2 2 2 2 LAGLIDADG DNA endonuclease family ATP-synt_A PF00119.15 ERZ94522.1 - 1.9e-55 187.7 24.8 2.3e-55 187.4 17.2 1.0 1 0 0 1 1 1 1 ATP synthase A chain COX2 PF00116.15 ERZ94524.1 - 2.1e-51 172.8 0.0 2.7e-51 172.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.10 ERZ94524.1 - 7.2e-19 67.5 1.1 1.5e-18 66.5 0.8 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain ATP-synt_C PF00137.16 ERZ94526.1 - 1.5e-19 69.6 13.4 1.7e-19 69.4 9.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit C DUF2938 PF11158.3 ERZ94526.1 - 0.07 12.4 1.8 0.083 12.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2938) DUF1469 PF07332.6 ERZ94526.1 - 9.1 6.0 14.2 23 4.7 9.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1469) GIY-YIG PF01541.19 ERZ94527.1 - 7.3e-07 29.4 0.0 1.1e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 GIY-YIG catalytic domain DNA_pol_B_2 PF03175.8 ERZ94528.1 - 1.9e-56 191.6 0.2 5.4e-42 144.0 0.0 2.1 1 1 1 2 2 2 2 DNA polymerase type B, organellar and viral NUMOD3 PF07460.6 ERZ94528.1 - 1.4e-06 28.0 2.3 5.1e-06 26.2 1.6 2.0 1 0 0 1 1 1 1 NUMOD3 motif (2 copies) GIY-YIG PF01541.19 ERZ94529.1 - 9.3e-07 29.1 0.0 1.8e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain NUMOD3 PF07460.6 ERZ94529.1 - 9.3e-05 22.2 0.1 0.016 15.1 0.0 2.2 2 0 0 2 2 2 2 NUMOD3 motif (2 copies) GIY-YIG PF01541.19 ERZ94530.1 - 1.7e-06 28.3 0.1 3.4e-06 27.3 0.0 1.5 2 0 0 2 2 2 1 GIY-YIG catalytic domain Oxidored_q1_N PF00662.15 ERZ94531.1 - 4.3e-25 87.0 3.9 1.2e-24 85.6 2.7 1.8 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q1 PF00361.15 ERZ94531.1 - 6e-24 84.7 8.3 6e-24 84.7 5.8 2.2 1 1 1 2 2 2 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1 PF00361.15 ERZ94532.1 - 2e-40 138.7 12.1 2e-40 138.7 8.4 2.1 2 0 0 2 2 2 1 NADH-Ubiquinone/plastoquinone (complex I), various chains NADH5_C PF06455.6 ERZ94532.1 - 2.1e-07 30.4 3.3 3.9e-05 23.0 0.3 3.5 4 1 0 4 4 4 2 NADH dehydrogenase subunit 5 C-terminus Oxidored_q1_C PF01010.14 ERZ94532.1 - 0.023 14.2 1.5 0.053 13.0 1.0 1.7 1 1 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus LAGLIDADG_1 PF00961.14 ERZ94533.1 - 0.031 14.8 0.0 0.074 13.6 0.0 1.6 1 0 0 1 1 1 0 LAGLIDADG endonuclease Cytochrom_B_C PF00032.12 ERZ94534.1 - 2e-39 133.9 7.0 2e-39 133.9 4.9 3.2 2 1 1 3 3 3 1 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N_2 PF13631.1 ERZ94534.1 - 1.2e-27 96.7 21.9 1.5e-18 67.1 4.6 3.9 3 2 1 4 4 4 2 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_N PF00033.14 ERZ94534.1 - 2e-10 40.3 16.1 2e-10 40.3 11.2 3.7 3 2 1 4 4 4 2 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 ERZ94534.1 - 0.0099 15.2 4.8 0.0099 15.2 3.4 3.7 1 1 1 3 3 3 2 Prokaryotic cytochrome b561 Oxidored_q1 PF00361.15 ERZ94535.1 - 4.9e-59 199.7 32.0 4.9e-59 199.7 22.2 2.0 2 0 0 2 2 2 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q5_N PF01059.12 ERZ94535.1 - 0.00062 19.6 5.1 0.00062 19.6 3.6 4.0 3 1 0 3 3 3 1 NADH-ubiquinone oxidoreductase chain 4, amino terminus Laminin_II PF06009.7 ERZ94536.1 - 2.8 7.6 17.4 0.17 11.6 4.0 2.9 3 0 0 3 3 3 0 Laminin Domain II Fib_alpha PF08702.5 ERZ94536.1 - 3.8 7.6 23.9 0.4 10.8 4.4 3.3 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family COG2 PF06148.6 ERZ94536.1 - 4.6 7.1 12.2 5.7 6.8 0.8 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 APG6 PF04111.7 ERZ94536.1 - 8.1 5.3 29.3 0.24 10.3 3.8 2.3 2 1 0 2 2 2 0 Autophagy protein Apg6 DUF3453 PF11935.3 ERZ94537.1 - 0.008 15.6 0.1 0.0098 15.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) zf-RVT PF13966.1 ERZ94538.1 - 0.028 14.7 1.3 0.038 14.2 0.1 1.8 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase zf-Sec23_Sec24 PF04810.10 ERZ94538.1 - 0.13 11.8 1.2 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-MIZ PF02891.15 ERZ94538.1 - 0.19 11.2 0.2 0.19 11.2 0.1 1.9 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger RE_Alw26IDE PF09665.5 ERZ94539.1 - 0.0054 15.4 0.6 0.014 14.1 0.0 1.7 1 1 1 2 2 2 1 Type II restriction endonuclease (RE_Alw26IDE) GAS PF13851.1 ERZ94539.1 - 0.021 14.0 4.9 0.03 13.5 3.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding MAP65_ASE1 PF03999.7 ERZ94539.1 - 0.037 12.6 2.3 0.047 12.2 1.6 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) FWWh PF14922.1 ERZ94539.1 - 0.058 12.8 0.4 0.076 12.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF2258 PF10015.4 ERZ94539.1 - 0.091 12.5 0.5 0.2 11.4 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) DUF2570 PF10828.3 ERZ94539.1 - 0.13 11.8 1.1 0.23 11.0 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) Myb_DNA-bind_6 PF13921.1 ERZ94541.1 - 0.00016 21.7 2.7 0.017 15.2 0.2 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain KRTDAP PF15200.1 ERZ94541.1 - 0.0061 16.3 0.4 1.4 8.7 0.0 2.1 2 0 0 2 2 2 2 Keratinocyte differentiation-associated Myb_DNA-binding PF00249.26 ERZ94541.1 - 0.072 13.1 0.2 0.44 10.6 0.1 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain Lipase_GDSL PF00657.17 ERZ94542.1 - 7.7e-16 58.6 0.5 9.8e-16 58.2 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Retrotrans_gag PF03732.12 ERZ94542.1 - 0.089 12.8 0.0 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 Retrotransposon gag protein NTF2 PF02136.15 ERZ94543.1 - 1e-32 112.9 0.1 1.2e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain OKR_DC_1_C PF03711.10 ERZ94543.1 - 0.095 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain DUF4518 PF15008.1 ERZ94543.1 - 0.14 11.2 0.1 0.31 10.0 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Orbi_NS3 PF01616.11 ERZ94544.1 - 0.042 12.7 0.3 0.049 12.5 0.2 1.0 1 0 0 1 1 1 0 Orbivirus NS3 FACT-Spt16_Nlob PF14826.1 ERZ94545.1 - 2.3e-41 141.0 2.7 2.3e-41 141.0 1.8 1.5 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 ERZ94545.1 - 2.5e-20 72.9 0.0 4e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Metallophos PF00149.23 ERZ94546.1 - 0.00032 20.1 8.9 0.0012 18.3 6.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.6 ERZ94547.1 - 3.6e-05 23.3 0.0 6.7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) Methyltransf_23 PF13489.1 ERZ94548.1 - 1.2e-15 57.5 0.0 1.8e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ94548.1 - 6.8e-13 48.4 0.3 1e-05 25.1 0.0 2.6 2 1 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ94548.1 - 1.1e-11 45.0 0.0 2.6e-11 43.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ94548.1 - 8.6e-08 32.7 0.0 1.7e-05 25.3 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ94548.1 - 1.6e-07 31.5 0.0 9.8e-07 29.0 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ94548.1 - 1.7e-07 30.5 0.0 2.1e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.10 ERZ94548.1 - 1.4e-06 28.0 0.0 2.7e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.7 ERZ94548.1 - 2e-06 28.2 0.0 1.7e-05 25.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ94548.1 - 6.1e-06 25.5 0.0 9.6e-05 21.5 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 ERZ94548.1 - 4.5e-05 23.4 0.0 9e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 ERZ94548.1 - 0.00034 19.0 0.0 0.0022 16.4 0.0 2.0 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 ERZ94548.1 - 0.0095 15.3 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.6 ERZ94548.1 - 0.054 12.1 0.0 0.092 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MTS PF05175.9 ERZ94548.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 ERZ94548.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 ERZ94548.1 - 0.12 12.3 0.0 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase RNase_H PF00075.19 ERZ94549.1 - 1.7e-12 47.7 0.1 3.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.1 ERZ94549.1 - 0.038 14.2 0.4 0.038 14.2 0.3 2.6 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase OrfB_Zn_ribbon PF07282.6 ERZ94549.1 - 7.7 6.2 9.4 9.6 5.9 0.3 3.1 3 0 0 3 3 3 0 Putative transposase DNA-binding domain RNase_H PF00075.19 ERZ94550.1 - 1.1e-10 41.9 0.1 2.8e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 RNase H F-box-like PF12937.2 ERZ94553.1 - 1.7e-07 30.8 1.7 4.8e-07 29.4 1.2 1.7 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.20 ERZ94554.1 - 1.6e-36 125.8 0.0 1.9e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94554.1 - 1.5e-35 122.5 0.0 1.8e-35 122.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ94554.1 - 0.00016 21.0 0.0 0.00023 20.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ94554.1 - 0.00072 18.6 0.0 0.00091 18.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ94554.1 - 0.00096 18.9 0.2 0.008 15.9 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ94554.1 - 0.0013 17.9 0.0 0.0021 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ERZ94554.1 - 0.042 13.1 0.0 0.081 12.2 0.0 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ94554.1 - 0.048 12.7 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_topoisoIV PF00521.15 ERZ94555.1 - 3e-119 398.6 0.4 6.4e-119 397.5 0.1 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 ERZ94555.1 - 3.7e-29 101.1 1.1 1.3e-28 99.3 0.8 2.0 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 ERZ94555.1 - 7.5e-13 48.3 0.0 4.4e-12 45.8 0.0 2.4 3 0 0 3 3 3 1 Toprim domain Dimer_Tnp_hAT PF05699.9 ERZ94557.1 - 0.00037 20.0 0.0 0.00039 20.0 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TF_AP-2 PF03299.9 ERZ94558.1 - 0.016 14.7 0.2 0.041 13.4 0.1 1.7 2 0 0 2 2 2 0 Transcription factor AP-2 Nop14 PF04147.7 ERZ94558.1 - 0.45 8.3 8.6 0.53 8.1 6.0 1.1 1 0 0 1 1 1 0 Nop14-like family DUF1108 PF06531.6 ERZ94558.1 - 1.8 8.7 5.4 3.2 7.9 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) DUF3453 PF11935.3 ERZ94559.1 - 4.5e-34 117.9 1.2 7.3e-34 117.2 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) Nha1_C PF08619.5 ERZ94559.1 - 0.023 14.0 3.1 0.033 13.4 2.2 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Cohesin_HEAT PF12765.2 ERZ94560.1 - 0.019 14.8 0.0 0.034 14.0 0.0 1.5 1 1 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion tRNA_anti_2 PF13742.1 ERZ94562.1 - 0.02 14.7 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Dimer_Tnp_hAT PF05699.9 ERZ94563.1 - 0.017 14.7 0.1 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region TF_AP-2 PF03299.9 ERZ94564.1 - 0.0035 16.9 0.4 0.0045 16.5 0.3 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 DUF3296 PF11726.3 ERZ94565.1 - 0.012 15.1 0.7 0.016 14.7 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3296) DUF4448 PF14610.1 ERZ94566.1 - 0.0045 16.5 4.1 0.0053 16.2 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF4101 PF13355.1 ERZ94566.1 - 0.27 11.6 3.9 0.35 11.3 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4101) HTH_Tnp_Tc3_2 PF01498.13 ERZ94567.1 - 0.061 13.3 0.5 0.22 11.5 0.4 1.9 1 1 0 1 1 1 0 Transposase UQ_con PF00179.21 ERZ94568.1 - 2e-49 166.6 0.0 2.2e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ERZ94568.1 - 0.00017 21.4 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ERZ94568.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 UEV domain Prok-E2_B PF14461.1 ERZ94568.1 - 0.022 14.5 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B FmdE PF02663.9 ERZ94571.1 - 0.075 12.9 0.1 0.085 12.7 0.1 1.0 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon DUF3080 PF11279.3 ERZ94571.1 - 0.093 11.8 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Pkinase_Tyr PF07714.12 ERZ94576.1 - 1.7e-41 141.9 0.0 7e-40 136.7 0.0 3.3 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94576.1 - 5.1e-39 133.9 1.7 7.8e-38 130.1 0.0 3.2 3 0 0 3 3 3 1 Protein kinase domain BCS1_N PF08740.6 ERZ94576.1 - 2.2e-06 27.3 1.3 0.5 9.9 0.0 4.1 5 0 0 5 5 5 3 BCS1 N terminal DUF3279 PF11682.3 ERZ94576.1 - 0.014 14.9 0.4 0.014 14.9 0.3 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF3279) APH PF01636.18 ERZ94576.1 - 0.28 10.8 0.1 0.46 10.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tir_receptor_C PF07489.6 ERZ94577.1 - 0.04 13.6 0.3 0.04 13.6 0.2 1.0 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Pkinase_Tyr PF07714.12 ERZ94578.1 - 1.7e-25 89.5 0.0 2.5e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94578.1 - 2e-24 86.1 0.1 3.6e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ94578.1 - 0.18 11.5 0.1 0.28 10.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family COG2 PF06148.6 ERZ94581.1 - 0.012 15.4 1.7 6.4 6.6 0.0 3.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 RmuC PF02646.11 ERZ94581.1 - 0.015 14.1 2.5 0.49 9.1 0.1 2.9 1 1 1 3 3 3 0 RmuC family Spectrin PF00435.16 ERZ94581.1 - 0.02 15.1 2.0 0.065 13.5 0.2 2.4 2 1 1 3 3 3 0 Spectrin repeat EzrA PF06160.7 ERZ94581.1 - 0.034 12.3 4.0 0.058 11.5 0.1 2.5 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA Baculo_PEP_C PF04513.7 ERZ94581.1 - 0.078 12.7 0.3 0.64 9.8 0.1 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ada3 PF10198.4 ERZ94581.1 - 0.94 9.2 5.1 1.1 9.0 0.3 2.3 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 Microtub_assoc PF07989.6 ERZ94583.1 - 0.00059 19.6 3.4 0.0054 16.5 0.7 2.4 2 0 0 2 2 2 1 Microtubule associated KxDL PF10241.4 ERZ94583.1 - 0.00068 19.4 5.7 0.0008 19.2 3.6 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein DivIVA PF05103.8 ERZ94583.1 - 0.0041 17.1 1.1 0.0041 17.1 0.8 2.1 1 1 1 2 2 2 1 DivIVA protein TMF_DNA_bd PF12329.3 ERZ94583.1 - 0.0078 15.9 8.3 0.074 12.8 3.0 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding bZIP_1 PF00170.16 ERZ94583.1 - 0.014 15.3 1.5 0.014 15.3 1.0 2.2 2 1 0 2 2 2 0 bZIP transcription factor DUF722 PF05263.6 ERZ94583.1 - 0.042 13.9 2.0 0.054 13.6 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF722) RE_EcoO109I PF14511.1 ERZ94583.1 - 0.046 13.1 0.9 0.069 12.5 0.6 1.3 1 1 0 1 1 1 0 Type II restriction endonuclease EcoO109I PRESAN PF09687.5 ERZ94583.1 - 0.091 12.8 4.0 0.096 12.7 2.4 1.3 1 1 0 1 1 1 0 Plasmodium RESA N-terminal ADIP PF11559.3 ERZ94583.1 - 0.22 11.4 10.1 0.74 9.7 2.1 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Pox_A_type_inc PF04508.7 ERZ94583.1 - 0.3 10.9 4.6 2.4 8.1 0.1 2.7 3 0 0 3 3 2 0 Viral A-type inclusion protein repeat TBPIP PF07106.8 ERZ94583.1 - 0.32 10.5 8.1 1.1 8.7 5.6 1.9 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FlxA PF14282.1 ERZ94583.1 - 0.35 10.8 3.7 3.7 7.5 0.5 2.2 2 0 0 2 2 2 0 FlxA-like protein TSC22 PF01166.13 ERZ94583.1 - 0.44 10.5 3.6 0.88 9.5 0.8 2.4 1 1 1 2 2 2 0 TSC-22/dip/bun family Val_tRNA-synt_C PF10458.4 ERZ94583.1 - 0.55 10.3 5.6 18 5.5 0.9 3.2 3 1 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm Scaffolding_pro PF11418.3 ERZ94583.1 - 0.57 10.5 3.3 2.3 8.5 2.1 2.0 1 1 1 2 2 2 0 Phi29 scaffolding protein IncA PF04156.9 ERZ94583.1 - 0.61 9.6 5.3 1.3 8.5 3.7 1.5 1 1 0 1 1 1 0 IncA protein DUF4446 PF14584.1 ERZ94583.1 - 1.1 9.0 4.9 0.5 10.1 1.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Atg14 PF10186.4 ERZ94583.1 - 1.2 8.0 7.4 4.4 6.1 0.1 2.0 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Suppressor_APC PF11414.3 ERZ94583.1 - 1.3 8.8 7.3 5.3 6.8 0.7 2.1 1 1 1 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein DUF972 PF06156.8 ERZ94583.1 - 1.5 9.2 7.0 0.64 10.3 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF1664 PF07889.7 ERZ94583.1 - 2.3 8.0 6.1 3 7.6 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3287 PF11690.3 ERZ94583.1 - 2.4 8.2 8.3 1.4 9.0 4.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) Cep57_CLD_2 PF14197.1 ERZ94583.1 - 3.5 7.6 6.4 11 5.9 0.8 2.4 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DivIC PF04977.10 ERZ94583.1 - 3.9 7.0 8.0 0.99 8.9 0.9 2.4 2 1 1 3 3 3 0 Septum formation initiator DUF2681 PF10883.3 ERZ94583.1 - 4.4 7.5 8.2 0.84 9.8 3.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) YgaB PF14182.1 ERZ94583.1 - 5.8 7.2 10.4 11 6.3 4.1 2.3 1 1 1 2 2 2 0 YgaB-like protein KH_1 PF00013.24 ERZ94584.1 - 1.4e-07 31.0 3.6 4.2e-07 29.4 2.5 1.8 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ94584.1 - 8.6e-07 28.4 2.6 2.2e-06 27.1 1.8 1.8 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ERZ94584.1 - 0.077 12.6 1.9 0.11 12.1 0.2 2.0 2 0 0 2 2 2 0 KH domain SusD-like_3 PF14322.1 ERZ94584.1 - 0.12 12.3 0.5 0.23 11.4 0.3 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Kelch_4 PF13418.1 ERZ94585.1 - 2e-20 72.2 10.5 0.0017 18.0 0.2 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ94585.1 - 8e-19 67.2 2.9 0.0011 19.0 0.0 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ERZ94585.1 - 1.8e-16 59.6 7.7 9.8e-05 22.2 0.5 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ERZ94585.1 - 5.5e-16 57.9 13.8 0.0028 17.7 0.0 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ERZ94585.1 - 3.9e-12 45.5 9.9 0.15 11.6 0.0 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ERZ94585.1 - 1.3e-11 43.7 1.4 0.71 9.7 0.0 5.3 5 0 0 5 5 5 4 Kelch motif STE3 PF02076.10 ERZ94586.1 - 0.0013 17.8 2.1 0.0042 16.2 0.3 2.2 2 0 0 2 2 2 1 Pheromone A receptor Apis_Csd PF11671.3 ERZ94586.1 - 8.9 6.1 15.7 0.048 13.4 3.9 2.1 2 0 0 2 2 2 0 Complementary sex determiner protein Pkinase PF00069.20 ERZ94587.1 - 2.8e-11 43.0 0.1 3.2e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94587.1 - 2.8e-07 29.9 0.0 3.2e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ERZ94587.1 - 0.065 13.1 0.0 0.39 10.6 0.0 2.0 1 1 1 2 2 2 0 ABC1 family Kinesin PF00225.18 ERZ94588.1 - 2.2e-07 29.9 0.0 2.7e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain P2 PF07194.6 ERZ94588.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 P2 response regulator binding domain Pkinase PF00069.20 ERZ94589.1 - 4.1e-09 35.9 0.0 5.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94589.1 - 1.9e-05 23.8 0.0 2.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase tRNA-synt_1g PF09334.6 ERZ94590.1 - 3.1e-148 493.6 1.3 4e-148 493.2 0.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ERZ94590.1 - 3e-11 42.0 0.5 5.6e-06 24.6 0.0 3.2 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) DZR PF12773.2 ERZ94590.1 - 0.39 10.5 9.1 2 8.3 6.3 2.1 1 1 0 1 1 1 0 Double zinc ribbon TPR_16 PF13432.1 ERZ94591.1 - 4.1e-17 62.3 3.8 0.0018 18.8 0.1 7.6 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ94591.1 - 2.8e-16 58.5 0.2 0.21 12.3 0.0 9.1 8 2 2 10 10 10 3 Tetratricopeptide repeat Apc3 PF12895.2 ERZ94591.1 - 2.2e-15 56.5 28.9 0.0033 17.5 0.1 6.4 3 3 3 6 6 6 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ERZ94591.1 - 1.6e-14 53.3 30.5 0.0022 17.5 0.0 8.2 6 3 2 9 9 9 7 TPR repeat TPR_2 PF07719.12 ERZ94591.1 - 3.7e-14 51.4 25.9 0.012 15.5 0.1 10.2 11 0 0 11 11 10 4 Tetratricopeptide repeat SRP72 PF08492.7 ERZ94591.1 - 3.9e-14 52.7 11.4 1.1e-13 51.3 7.9 1.8 1 0 0 1 1 1 1 SRP72 RNA-binding domain TPR_12 PF13424.1 ERZ94591.1 - 4.7e-14 52.0 17.0 2.6e-07 30.4 0.4 5.6 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ94591.1 - 9.7e-14 51.4 20.7 0.0045 17.3 0.0 8.2 2 2 7 10 10 10 6 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ94591.1 - 1.2e-11 43.5 4.7 0.16 11.8 0.0 7.3 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ94591.1 - 2.8e-10 39.2 17.9 0.045 13.5 0.1 9.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ94591.1 - 1.7e-09 36.8 26.5 0.024 14.2 0.1 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ94591.1 - 5.1e-08 32.8 21.0 0.23 12.0 0.1 9.9 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ94591.1 - 6.2e-07 29.1 0.8 2.6 7.9 0.0 5.6 5 1 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ERZ94591.1 - 2.6e-06 27.2 17.9 0.059 13.2 0.0 6.4 5 1 1 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat SNAP PF14938.1 ERZ94591.1 - 5.8e-06 25.6 0.2 5.8e-06 25.6 0.1 3.9 3 2 1 4 4 4 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.1 ERZ94591.1 - 4.3e-05 23.2 0.7 8.4 6.4 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.7 ERZ94591.1 - 0.00023 20.8 20.7 0.012 15.4 0.1 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ94591.1 - 0.00033 20.6 9.8 10 6.6 0.1 6.8 7 0 0 7 7 6 0 Tetratricopeptide repeat BTAD PF03704.12 ERZ94591.1 - 0.0013 19.0 0.1 2.3 8.5 0.0 4.4 4 2 2 6 6 6 1 Bacterial transcriptional activator domain Alkyl_sulf_dimr PF14863.1 ERZ94591.1 - 0.12 12.6 8.9 2 8.6 0.0 3.8 4 1 1 5 5 4 0 Alkyl sulfatase dimerisation Foie-gras_1 PF11817.3 ERZ94591.1 - 0.52 9.7 5.3 3.2 7.1 0.5 3.6 2 2 1 4 4 4 0 Foie gras liver health family 1 TPR_20 PF14561.1 ERZ94591.1 - 2.8 8.1 10.9 3.5 7.8 0.0 5.2 6 1 0 6 6 5 0 Tetratricopeptide repeat Myb_DNA-binding PF00249.26 ERZ94592.1 - 2e-51 171.8 25.8 9.9e-15 54.3 0.2 5.2 5 1 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ94592.1 - 4.7e-48 161.1 20.5 8e-15 54.6 0.1 5.1 2 2 3 5 5 5 5 Myb-like DNA-binding domain Rap1_C PF11626.3 ERZ94592.1 - 0.013 15.3 12.4 3.9 7.4 0.5 3.8 1 1 2 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.4 ERZ94592.1 - 0.63 10.2 19.3 0.28 11.3 1.8 4.6 3 1 2 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.1 ERZ94592.1 - 4.8 7.3 30.7 8.9 6.5 1.9 6.3 4 2 1 6 6 6 0 Myb/SANT-like DNA-binding domain UBA PF00627.26 ERZ94593.1 - 5.9e-05 22.7 0.1 9.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain Rhomboid PF01694.17 ERZ94593.1 - 6.6e-05 22.9 6.9 0.00011 22.2 4.8 1.3 1 0 0 1 1 1 1 Rhomboid family CUE PF02845.11 ERZ94593.1 - 9.1e-05 21.8 0.2 0.00016 21.0 0.1 1.4 1 0 0 1 1 1 1 CUE domain DUF1751 PF08551.5 ERZ94593.1 - 0.075 13.3 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) Exo_endo_phos_2 PF14529.1 ERZ94598.1 - 3.2e-05 23.5 0.2 0.00015 21.3 0.1 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ94598.1 - 0.00058 19.8 0.0 0.0008 19.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3336 PF11815.3 ERZ94598.1 - 0.084 12.3 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) Suf PF05843.9 ERZ94601.1 - 0.087 12.5 0.0 0.096 12.3 0.0 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2518 PF10726.4 ERZ94603.1 - 0.079 12.4 0.2 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of function (DUF2518) p450 PF00067.17 ERZ94605.1 - 5.3e-93 312.0 0.0 6.6e-93 311.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ94606.1 - 1.7e-92 310.3 0.1 2.2e-92 309.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CtIP_N PF10482.4 ERZ94606.1 - 0.084 12.6 4.1 0.18 11.5 2.9 1.5 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain p450 PF00067.17 ERZ94607.1 - 2.3e-76 257.2 0.0 3.4e-76 256.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF4405 PF14358.1 ERZ94607.1 - 0.1 12.7 1.2 0.31 11.2 0.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4405) p450 PF00067.17 ERZ94608.1 - 3.7e-89 299.3 0.0 4.7e-89 299.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ94609.1 - 1.9e-79 267.3 0.0 2.2e-79 267.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CtIP_N PF10482.4 ERZ94609.1 - 0.076 12.7 3.3 0.074 12.8 1.2 1.8 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain BTB PF00651.26 ERZ94611.1 - 7.5e-05 22.6 0.0 9.8e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Arch_ATPase PF01637.13 ERZ94612.1 - 1.1e-05 25.3 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ERZ94612.1 - 3.5e-05 23.6 0.0 5.8e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ERZ94612.1 - 4e-05 23.6 0.0 4.2e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ERZ94612.1 - 0.00018 21.6 0.0 0.00025 21.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 ERZ94612.1 - 0.0023 18.4 0.0 0.0043 17.5 0.0 1.6 1 1 0 1 1 1 1 Miro-like protein AAA_28 PF13521.1 ERZ94612.1 - 0.0026 17.7 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ94612.1 - 0.0028 17.8 0.0 0.0045 17.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Beach PF02138.13 ERZ94612.1 - 0.0069 15.8 0.3 0.0077 15.6 0.2 1.2 1 0 0 1 1 1 1 Beige/BEACH domain AAA_19 PF13245.1 ERZ94612.1 - 0.011 15.5 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 ERZ94612.1 - 0.013 15.8 2.9 0.094 13.0 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.1 ERZ94612.1 - 0.013 15.0 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ERZ94612.1 - 0.043 13.2 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 ERZ94612.1 - 0.045 12.6 0.0 0.048 12.5 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.1 ERZ94612.1 - 0.052 13.4 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA12 PF10443.4 ERZ94612.1 - 0.096 11.1 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein ATP-synt_ab PF00006.20 ERZ94612.1 - 0.097 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 ERZ94612.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 ERZ94612.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Synapsin_N PF10581.4 ERZ94612.1 - 1.1 9.1 4.2 0.74 9.6 0.4 2.3 2 1 0 2 2 2 0 Synapsin N-terminal Pkinase PF00069.20 ERZ94614.1 - 9.7e-37 126.5 0.8 1.3e-36 126.1 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94614.1 - 2.6e-36 125.0 0.0 5.4e-36 124.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase AMP-binding PF00501.23 ERZ94616.1 - 3.1e-93 312.4 0.0 4e-93 312.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF1443 PF07280.6 ERZ94616.1 - 0.017 14.6 0.3 0.034 13.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) AMP-binding_C PF13193.1 ERZ94616.1 - 0.09 13.7 0.0 0.18 12.7 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DUF2097 PF09870.4 ERZ94617.1 - 0.0021 18.1 4.3 0.2 11.7 0.2 3.1 3 0 0 3 3 3 2 Uncharacterized protein conserved in archaea (DUF2097) DZR PF12773.2 ERZ94617.1 - 9.8 6.0 21.1 0.76 9.6 0.8 3.3 2 1 0 2 2 2 0 Double zinc ribbon Pkinase_Tyr PF07714.12 ERZ94618.1 - 8.4e-40 136.4 0.0 9.9e-40 136.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94618.1 - 1.6e-36 125.7 0.0 2e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ94618.1 - 0.00079 18.5 0.1 0.0011 18.0 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ94618.1 - 0.0082 15.4 0.1 0.017 14.4 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL YjcQ PF09639.5 ERZ94618.1 - 0.0095 16.0 2.4 0.012 15.7 0.5 1.9 2 1 0 2 2 2 1 YjcQ protein APH PF01636.18 ERZ94618.1 - 0.017 14.8 0.1 0.024 14.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsaN PF05479.6 ERZ94618.1 - 0.14 12.1 0.2 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) TRA-1_regulated PF02343.11 ERZ94621.1 - 0.04 13.4 0.1 0.071 12.6 0.1 1.4 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 TRA-1_regulated PF02343.11 ERZ94624.1 - 0.04 13.4 0.1 0.058 12.8 0.1 1.2 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 AvrD PF05655.6 ERZ94624.1 - 0.051 12.4 0.0 0.062 12.1 0.0 1.1 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) Pkinase PF00069.20 ERZ94625.1 - 7.9e-11 41.5 0.1 9.1e-11 41.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94625.1 - 1e-07 31.2 0.0 1.2e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ERZ94625.1 - 0.1 12.5 0.0 0.42 10.5 0.0 1.9 1 1 1 2 2 2 0 ABC1 family Glyco_hydro_28 PF00295.12 ERZ94625.1 - 0.12 11.3 0.2 0.13 11.2 0.2 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 28 Pkinase PF00069.20 ERZ94626.1 - 9.5e-36 123.2 0.5 1.2e-35 122.9 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94626.1 - 8.7e-35 120.0 0.1 1.1e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ94626.1 - 0.00048 19.2 0.6 0.00062 18.8 0.4 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ94626.1 - 0.00083 19.1 0.5 0.002 17.8 0.4 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ94626.1 - 0.0011 18.3 0.6 0.002 17.5 0.4 1.6 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ94626.1 - 0.0078 15.5 0.1 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ERZ94626.1 - 0.03 13.2 0.0 0.54 9.1 0.0 2.1 1 1 0 2 2 2 0 Kinase-like DUF4286 PF14114.1 ERZ94626.1 - 0.058 13.6 4.0 2.4 8.4 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) FTA2 PF13095.1 ERZ94626.1 - 0.059 12.9 0.4 0.1 12.1 0.1 1.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF1086 PF06461.6 ERZ94626.1 - 0.092 12.5 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) Pkinase PF00069.20 ERZ94627.1 - 2.2e-46 158.1 0.1 3e-46 157.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94627.1 - 7.6e-44 149.7 0.0 9e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ94627.1 - 0.002 17.5 0.8 0.0057 16.0 0.1 1.8 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ERZ94627.1 - 0.0027 17.4 0.1 0.077 12.7 0.5 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ94627.1 - 0.013 14.5 0.0 0.15 11.0 0.0 2.0 2 0 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.4 ERZ94627.1 - 0.045 13.0 0.1 0.12 11.6 0.1 1.7 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL PAN_3 PF08277.7 ERZ94627.1 - 0.064 12.8 0.2 0.24 11.0 0.1 2.0 1 0 0 1 1 1 0 PAN-like domain Kdo PF06293.9 ERZ94627.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.2 ERZ94628.1 - 4.8e-06 26.1 0.4 1.5e-05 24.6 0.3 1.8 1 0 0 1 1 1 1 F-box-like Ribosomal_S8 PF00410.14 ERZ94628.1 - 0.16 11.8 1.3 0.75 9.6 0.2 2.1 1 1 0 2 2 2 0 Ribosomal protein S8 Pkinase PF00069.20 ERZ94629.1 - 3.8e-22 78.6 0.1 4.3e-22 78.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94629.1 - 1.1e-18 67.3 0.0 1.2e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_A32 PF04665.7 ERZ94630.1 - 5e-05 22.7 0.1 5.8e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Poxvirus A32 protein DUF552 PF04472.7 ERZ94630.1 - 0.08 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF552) End_N_terminal PF12218.3 ERZ94630.1 - 0.13 11.7 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase RNase_H PF00075.19 ERZ94634.1 - 0.00029 21.1 0.1 0.00038 20.8 0.0 1.2 1 0 0 1 1 1 1 RNase H RNase_H PF00075.19 ERZ94635.1 - 0.00029 21.2 0.0 0.00037 20.8 0.0 1.2 1 0 0 1 1 1 1 RNase H RNase_H PF00075.19 ERZ94636.1 - 0.00021 21.6 0.2 0.00036 20.8 0.0 1.5 2 0 0 2 2 2 1 RNase H DASH_Ask1 PF08655.5 ERZ94637.1 - 0.035 13.9 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Ask1 DUF2397 PF09660.5 ERZ94637.1 - 0.095 11.2 0.0 0.1 11.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Sel1 PF08238.7 ERZ94638.1 - 1.5e-106 346.4 62.8 1.7e-12 47.5 2.9 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_20 PF14561.1 ERZ94638.1 - 5.5e-07 29.6 3.1 0.55 10.3 0.0 5.7 3 2 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ94638.1 - 2.4e-05 24.4 23.8 0.028 14.8 0.4 8.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ94638.1 - 2.6e-05 24.0 34.5 1.2 9.5 0.1 10.5 10 2 1 11 11 10 3 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ94638.1 - 0.00022 21.7 2.8 1.9 9.2 0.0 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.13 ERZ94638.1 - 0.00035 20.3 27.0 1.7 8.5 0.6 7.8 7 2 1 8 8 8 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.1 ERZ94638.1 - 0.019 15.3 9.9 15 6.0 0.0 6.3 5 2 1 6 6 6 0 Tetratricopeptide repeat AAA_25 PF13481.1 ERZ94638.1 - 0.071 12.4 0.0 21 4.4 0.0 3.2 2 1 1 3 3 3 0 AAA domain TPR_11 PF13414.1 ERZ94638.1 - 0.079 12.6 56.3 0.22 11.2 4.6 7.6 1 1 5 7 7 7 0 TPR repeat Surfac_D-trimer PF09006.6 ERZ94638.1 - 0.12 12.1 9.6 53 3.6 0.0 6.1 8 0 0 8 8 8 0 Lung surfactant protein D coiled-coil trimerisation DUF1580 PF07618.6 ERZ94638.1 - 2.3 7.6 6.0 6.6 6.1 0.0 3.9 6 0 0 6 6 6 0 Protein of unknown function (DUF1580) Bombinin PF05298.6 ERZ94638.1 - 7.2 6.0 6.4 34 3.9 0.1 4.6 4 2 1 6 6 6 0 Bombinin Sel1 PF08238.7 ERZ94639.1 - 2.7e-86 282.1 62.8 6.1e-13 48.9 0.7 9.4 9 1 0 9 9 9 9 Sel1 repeat MIT PF04212.13 ERZ94639.1 - 2e-05 24.3 48.1 0.3 10.9 0.1 8.6 7 2 0 7 7 7 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ERZ94639.1 - 0.00029 20.5 18.7 14 5.5 0.0 8.1 9 0 0 9 9 9 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ERZ94639.1 - 0.0029 17.6 27.3 1.9 8.8 0.5 8.5 7 3 1 8 8 8 2 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ERZ94639.1 - 0.017 14.8 0.1 11 5.5 0.0 4.0 2 2 1 3 3 3 0 Caspase domain ESAG1 PF03238.8 ERZ94639.1 - 0.085 12.1 3.7 2.9 7.1 0.0 3.7 3 2 1 4 4 4 0 ESAG protein TPR_6 PF13174.1 ERZ94639.1 - 0.16 12.5 29.5 1.4 9.5 0.2 7.3 7 1 0 7 7 7 0 Tetratricopeptide repeat NAPRTase PF04095.11 ERZ94639.1 - 0.22 10.7 2.3 11 5.2 0.0 3.1 2 1 0 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) family SnoaL_3 PF13474.1 ERZ94639.1 - 0.25 11.4 4.5 31 4.6 0.0 3.9 3 2 0 3 3 3 0 SnoaL-like domain TOM20_plant PF06552.7 ERZ94639.1 - 0.71 9.4 13.8 3.3 7.2 0.1 5.2 1 1 2 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 HTH_16 PF12645.2 ERZ94639.1 - 6.6 6.7 14.4 14 5.6 0.0 5.2 6 0 0 6 6 6 0 Helix-turn-helix domain Glu_syn_central PF04898.9 ERZ94639.1 - 9.6 5.3 10.6 13 4.9 0.1 4.3 2 2 2 5 5 5 0 Glutamate synthase central domain Pkinase_Tyr PF07714.12 ERZ94640.1 - 1.5e-05 24.1 0.0 4e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_A_type_inc PF04508.7 ERZ94640.1 - 0.087 12.6 1.0 12 6.0 0.2 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat HalX PF08663.5 ERZ94640.1 - 0.18 11.8 2.4 2.5 8.1 0.1 3.0 3 0 0 3 3 3 0 HalX domain BTB PF00651.26 ERZ94641.1 - 6e-18 64.8 0.0 1.3e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ94641.1 - 6.9e-15 55.2 1.7 8.9e-15 54.8 0.2 1.9 2 0 0 2 2 2 1 TLD ZZ PF00569.12 ERZ94641.1 - 9.6e-09 34.6 8.2 9.6e-09 34.6 5.7 2.4 2 0 0 2 2 2 1 Zinc finger, ZZ type BACK PF07707.10 ERZ94641.1 - 8.9e-07 28.6 3.1 3.6e-06 26.7 0.1 3.1 3 1 1 4 4 4 1 BTB And C-terminal Kelch Toxin_44 PF15523.1 ERZ94642.1 - 0.036 13.9 0.3 0.049 13.5 0.2 1.3 1 0 0 1 1 1 0 Putative toxin 44 FTA4 PF13093.1 ERZ94643.1 - 2.6e-29 102.1 10.6 2.6e-29 102.1 7.3 1.6 2 0 0 2 2 2 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DnaJ PF00226.26 ERZ94643.1 - 1.4e-12 47.1 0.2 6.9e-12 44.9 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain Wbp11 PF09429.5 ERZ94643.1 - 0.53 10.3 5.9 0.21 11.5 1.6 2.3 2 0 0 2 2 2 0 WW domain binding protein 11 ADSL_C PF10397.4 ERZ94644.1 - 1.4e-16 60.2 0.0 2e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus DNAJ_related PF12339.3 ERZ94645.1 - 0.0072 16.2 0.2 0.035 13.9 0.1 2.1 1 1 1 2 2 2 1 DNA-J related protein F-box-like PF12937.2 ERZ94645.1 - 0.059 13.1 0.6 0.17 11.6 0.4 1.8 1 0 0 1 1 1 0 F-box-like DUF829 PF05705.9 ERZ94646.1 - 0.047 13.3 0.5 0.14 11.8 0.2 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) ELH PF02323.10 ERZ94646.1 - 0.06 12.4 0.6 0.075 12.1 0.4 1.1 1 0 0 1 1 1 0 Egg-laying hormone precursor UPF0182 PF03699.8 ERZ94647.1 - 0.12 10.2 0.7 0.15 9.9 0.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF3751 PF12571.3 ERZ94648.1 - 0.048 13.4 0.0 0.052 13.3 0.0 1.0 1 0 0 1 1 1 0 Phage tail-collar fibre protein DUF3419 PF11899.3 ERZ94650.1 - 0.00038 19.2 0.0 0.00059 18.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Ribosomal_L10 PF00466.15 ERZ94650.1 - 0.062 13.2 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L10 PX PF00787.19 ERZ94651.1 - 2.3e-17 62.7 0.8 2.3e-17 62.7 0.5 2.3 2 1 0 2 2 2 1 PX domain E6 PF00518.12 ERZ94652.1 - 0.047 14.0 1.0 0.047 14.0 0.7 1.6 2 0 0 2 2 2 0 Early Protein (E6) DUF581 PF04570.9 ERZ94652.1 - 0.095 12.0 0.3 0.095 12.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF581) Pkinase PF00069.20 ERZ94653.1 - 4.2e-47 160.4 0.2 5.9e-47 159.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94653.1 - 6e-45 153.3 0.0 7.2e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ94653.1 - 0.00034 19.6 0.0 0.0089 15.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ94653.1 - 0.0015 18.3 0.1 0.041 13.6 0.2 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ94653.1 - 0.0028 17.0 0.7 0.014 14.7 0.5 1.9 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.9 ERZ94653.1 - 0.0081 15.2 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ERZ94653.1 - 0.02 14.1 0.2 0.032 13.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ERZ94653.1 - 0.049 12.9 0.1 0.12 11.7 0.1 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Amidohydro_5 PF13594.1 ERZ94654.1 - 7.4e-08 32.1 0.1 1.1e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_4 PF13147.1 ERZ94654.1 - 0.0046 17.0 0.0 0.006 16.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ERZ94655.1 - 4.3e-61 207.3 0.0 5.4e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family FlbD PF06289.6 ERZ94655.1 - 0.048 13.0 0.3 1.2 8.5 0.0 2.8 2 0 0 2 2 2 0 Flagellar protein (FlbD) Amidohydro_1 PF01979.15 ERZ94655.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 Amidohydrolase family Spherulin4 PF12138.3 ERZ94655.1 - 0.11 11.9 0.0 0.22 10.9 0.0 1.4 2 0 0 2 2 2 0 Spherulation-specific family 4 WD40 PF00400.27 ERZ94656.1 - 3.6e-17 61.5 0.2 0.00035 20.3 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 ERZ94656.1 - 0.0058 16.3 0.3 29 4.2 0.0 3.6 2 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A MRG PF05712.8 ERZ94656.1 - 0.021 13.6 0.1 0.03 13.2 0.1 1.1 1 0 0 1 1 1 0 MRG Ndc1_Nup PF09531.5 ERZ94658.1 - 0.0074 14.7 1.3 0.0095 14.4 0.9 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Cofilin_ADF PF00241.15 ERZ94659.1 - 2.2e-26 92.2 0.4 1e-14 54.5 0.1 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DNA_binding_1 PF01035.15 ERZ94661.1 - 3.6e-20 71.4 0.0 1.2e-19 69.8 0.0 1.9 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain WD40 PF00400.27 ERZ94662.1 - 1.1e-25 88.5 1.7 0.00033 20.4 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ERZ94662.1 - 4.6e-08 32.9 0.2 0.0028 17.4 0.0 3.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Pept_tRNA_hydro PF01195.14 ERZ94663.1 - 7.4e-44 149.4 0.1 4.5e-35 120.8 0.0 2.2 2 0 0 2 2 2 2 Peptidyl-tRNA hydrolase YqzE PF14038.1 ERZ94663.1 - 0.11 12.2 0.7 0.22 11.2 0.5 1.4 1 0 0 1 1 1 0 YqzE-like protein DUF1761 PF08570.5 ERZ94664.1 - 6.7e-21 74.6 3.3 8e-21 74.3 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Ala_racemase_N PF01168.15 ERZ94665.1 - 3.4e-35 121.5 0.0 1.4e-34 119.5 0.0 1.7 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain OSR1_C PF12202.3 ERZ94666.1 - 0.012 15.1 0.5 0.012 15.1 0.3 1.9 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C terminal FAR1 PF03101.10 ERZ94667.1 - 0.065 13.7 0.9 0.092 13.2 0.6 1.2 1 0 0 1 1 1 0 FAR1 DNA-binding domain Lipase_3 PF01764.20 ERZ94668.1 - 2.2e-19 69.4 0.0 6.2e-19 68.0 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ERZ94668.1 - 0.12 12.0 0.0 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Orbi_VP5 PF00901.12 ERZ94668.1 - 0.48 8.5 3.4 1.6 6.8 0.7 2.0 2 0 0 2 2 2 0 Orbivirus outer capsid protein VP5 Enkurin PF13864.1 ERZ94669.1 - 0.015 15.4 4.6 0.041 14.0 3.2 1.8 1 1 0 1 1 1 0 Calmodulin-binding Rop-like PF05082.8 ERZ94669.1 - 0.027 13.9 1.9 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Rop-like DUF4391 PF14335.1 ERZ94669.1 - 0.04 13.3 3.0 0.073 12.4 2.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) zf-C4H2 PF10146.4 ERZ94669.1 - 0.04 13.9 4.4 0.03 14.3 1.9 1.6 1 1 1 2 2 2 0 Zinc finger-containing protein Seryl_tRNA_N PF02403.17 ERZ94669.1 - 0.049 13.6 8.5 1 9.4 2.5 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlgN PF05130.7 ERZ94669.1 - 0.054 13.7 2.4 0.075 13.2 1.7 1.3 1 1 0 1 1 1 0 FlgN protein DivIC PF04977.10 ERZ94669.1 - 0.062 12.7 4.6 0.29 10.6 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator WD40_alt PF14077.1 ERZ94669.1 - 0.072 12.7 2.2 6.9 6.3 0.1 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif AHSP PF09236.5 ERZ94669.1 - 0.11 12.6 1.0 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein DUF4140 PF13600.1 ERZ94669.1 - 0.13 12.6 4.3 0.13 12.6 1.5 1.9 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.5 ERZ94669.1 - 0.16 12.1 3.3 0.2 11.7 2.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PNPase PF03726.9 ERZ94669.1 - 0.16 12.2 2.0 1 9.6 1.4 2.4 1 1 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DivIVA PF05103.8 ERZ94669.1 - 0.19 11.7 7.0 0.36 10.8 4.8 1.4 1 1 0 1 1 1 0 DivIVA protein UPF0242 PF06785.6 ERZ94669.1 - 0.27 9.8 3.4 0.31 9.6 2.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Vmethyltransf_C PF08456.5 ERZ94669.1 - 0.27 10.6 4.4 0.53 9.6 3.0 1.5 1 1 0 1 1 1 0 Viral methyltransferase C-terminal FliD_N PF02465.13 ERZ94669.1 - 0.28 11.5 5.1 6.5 7.1 0.1 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF2130 PF09903.4 ERZ94669.1 - 0.3 9.7 7.7 0.99 8.0 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) Syntaxin-6_N PF09177.6 ERZ94669.1 - 0.34 11.3 4.7 4.6 7.7 3.3 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TipAS PF07739.8 ERZ94669.1 - 0.37 11.1 2.8 0.86 9.9 0.2 2.0 1 1 0 2 2 2 0 TipAS antibiotic-recognition domain DUF1043 PF06295.7 ERZ94669.1 - 0.37 10.4 2.8 0.69 9.5 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Mnd1 PF03962.10 ERZ94669.1 - 0.38 10.4 7.5 2 8.0 5.2 2.0 1 1 0 1 1 1 0 Mnd1 family COG5 PF10392.4 ERZ94669.1 - 0.38 10.7 4.5 1.5 8.8 1.3 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 CENP-Q PF13094.1 ERZ94669.1 - 0.53 10.3 7.4 3.6 7.6 4.4 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FlaC_arch PF05377.6 ERZ94669.1 - 0.68 9.8 3.8 0.99 9.3 0.1 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) IncA PF04156.9 ERZ94669.1 - 0.76 9.3 10.1 11 5.5 6.5 2.0 1 1 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ERZ94669.1 - 0.94 9.4 8.5 0.27 11.2 2.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF972 PF06156.8 ERZ94669.1 - 1.6 9.1 5.7 13 6.2 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Prefoldin PF02996.12 ERZ94669.1 - 1.6 8.3 6.4 7.4 6.2 0.3 2.2 2 0 0 2 2 2 0 Prefoldin subunit ADIP PF11559.3 ERZ94669.1 - 1.8 8.4 8.8 0.64 9.9 2.6 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Kinetocho_Slk19 PF12709.2 ERZ94669.1 - 3.9 7.6 8.2 12 6.1 0.6 2.3 1 1 0 2 2 2 0 Central kinetochore-associated Sec5 PF15469.1 ERZ94670.1 - 0.031 13.9 0.1 0.05 13.3 0.1 1.4 1 1 0 1 1 1 0 Exocyst complex component Sec5 KMP11 PF03037.11 ERZ94671.1 - 0.015 15.8 0.4 0.022 15.3 0.3 1.5 1 1 0 1 1 1 0 Kinetoplastid membrane protein 11 His_Phos_2 PF00328.17 ERZ94671.1 - 0.47 9.7 2.5 4.3 6.5 2.0 1.8 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) Peptidase_S9 PF00326.16 ERZ94672.1 - 7.9e-39 133.0 0.0 1.2e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 ERZ94672.1 - 6.2e-09 35.6 0.0 9.3e-07 28.5 0.0 2.1 1 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_5 PF12695.2 ERZ94672.1 - 8.4e-09 35.3 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 ERZ94672.1 - 2.1e-06 27.1 0.0 1.3e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 ERZ94672.1 - 4.5e-06 26.6 0.0 1.3e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DPPIV_N PF00930.16 ERZ94672.1 - 0.0014 17.3 0.2 0.4 9.1 0.0 3.1 1 1 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region BAAT_C PF08840.6 ERZ94672.1 - 0.003 17.2 0.0 0.013 15.2 0.0 1.8 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.8 ERZ94672.1 - 0.0072 15.9 0.0 0.57 9.7 0.2 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 ERZ94672.1 - 0.018 14.6 0.0 2.7 7.4 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.15 ERZ94672.1 - 0.024 14.0 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative esterase COesterase PF00135.23 ERZ94672.1 - 0.028 13.1 0.0 0.046 12.4 0.0 1.3 1 0 0 1 1 1 0 Carboxylesterase family Pkinase PF00069.20 ERZ94673.1 - 3.7e-24 85.2 0.2 1.1e-23 83.7 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94673.1 - 9.7e-22 77.2 0.0 1.1e-21 77.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ94673.1 - 0.00045 20.0 0.4 0.0019 17.9 0.5 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ94673.1 - 0.0008 18.4 0.0 0.00091 18.2 0.0 1.0 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ERZ94673.1 - 0.0028 17.0 0.1 0.0029 17.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ94673.1 - 0.0061 15.6 0.1 0.0063 15.5 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ERZ94673.1 - 0.065 12.4 0.1 0.065 12.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) SUFU PF05076.8 ERZ94673.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Suppressor of fused protein (SUFU) FAM176 PF14851.1 ERZ94675.1 - 0.15 11.7 1.6 0.44 10.2 1.0 1.9 2 0 0 2 2 2 0 FAM176 family Cache_1 PF02743.13 ERZ94676.1 - 1.4 8.5 5.1 2 8.0 3.5 1.3 1 0 0 1 1 1 0 Cache domain DUF1700 PF08006.6 ERZ94676.1 - 1.5 8.0 8.4 1.5 8.1 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF4191 PF13829.1 ERZ94676.1 - 1.9 7.5 7.4 2 7.4 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) TcpE PF12648.2 ERZ94676.1 - 2.2 8.4 7.2 2.4 8.3 5.0 1.1 1 0 0 1 1 1 0 TcpE family SdpI PF13630.1 ERZ94676.1 - 2.2 8.0 8.2 3.4 7.4 5.7 1.3 1 0 0 1 1 1 0 SdpI/YhfL protein family SUR7 PF06687.7 ERZ94676.1 - 2.2 7.7 7.9 2.7 7.4 5.5 1.2 1 0 0 1 1 1 0 SUR7/PalI family DUF1469 PF07332.6 ERZ94676.1 - 5.5 6.7 13.7 6.6 6.4 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DUF3040 PF11239.3 ERZ94676.1 - 5.9 7.0 7.5 7.1 6.7 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) BTB PF00651.26 ERZ94678.1 - 3.4e-21 75.3 0.1 5.4e-21 74.6 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ERZ94678.1 - 0.0027 16.8 0.2 0.0034 16.5 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BACK PF07707.10 ERZ94678.1 - 0.05 13.4 3.2 2.3 8.1 0.2 3.7 3 1 1 4 4 4 0 BTB And C-terminal Kelch Fucokinase PF07959.7 ERZ94680.1 - 0.068 11.7 0.0 0.073 11.6 0.0 1.1 1 0 0 1 1 1 0 L-fucokinase Proteasome PF00227.21 ERZ94681.1 - 0.0034 16.6 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Pho88 PF10032.4 ERZ94682.1 - 2.1e-68 229.3 0.1 2.3e-68 229.2 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) N-Term_TEN PF11474.3 ERZ94682.1 - 0.0045 16.3 0.3 0.0067 15.8 0.2 1.3 1 0 0 1 1 1 1 Telomerase reverse transcriptase TEN domain Med26 PF08711.6 ERZ94682.1 - 0.1 12.1 0.1 0.24 10.9 0.1 1.6 1 0 0 1 1 1 0 TFIIS helical bundle-like domain WD40 PF00400.27 ERZ94683.1 - 1.1e-49 164.5 9.7 4.2e-10 39.1 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat Striatin PF08232.7 ERZ94683.1 - 1.5e-43 148.3 1.8 1.5e-43 148.3 1.2 3.3 2 1 1 3 3 3 1 Striatin family DUF1515 PF07439.6 ERZ94684.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Imm41 PF15583.1 ERZ94685.1 - 0.047 13.5 0.0 0.055 13.2 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 41 YkyA PF10368.4 ERZ94686.1 - 0.051 12.9 3.1 0.052 12.8 2.2 1.0 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein V-set PF07686.12 ERZ94686.1 - 0.28 11.0 1.6 0.33 10.8 1.1 1.1 1 0 0 1 1 1 0 Immunoglobulin V-set domain Ter PF05472.6 ERZ94688.1 - 0.031 13.4 0.6 0.038 13.1 0.4 1.2 1 0 0 1 1 1 0 DNA replication terminus site-binding protein (Ter protein) Cript PF10235.4 ERZ94688.1 - 0.047 14.0 0.2 0.079 13.3 0.1 1.4 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT HSP70 PF00012.15 ERZ94688.1 - 0.2 9.5 6.4 0.23 9.3 4.4 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF4196 PF13846.1 ERZ94688.1 - 0.4 11.0 5.0 0.67 10.2 3.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4196) PG_binding_4 PF12229.3 ERZ94688.1 - 1.4 9.1 7.2 1.6 8.9 3.7 1.9 1 1 1 2 2 2 0 Putative peptidoglycan binding domain DUF4159 PF13709.1 ERZ94689.1 - 0.083 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) GATase_2 PF00310.16 ERZ94689.1 - 0.083 11.5 7.3 4.9 5.7 0.1 3.0 2 1 0 2 2 2 0 Glutamine amidotransferases class-II Pkinase PF00069.20 ERZ94690.1 - 4.9e-21 75.0 0.0 6.2e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94690.1 - 3.7e-18 65.5 0.0 5.9e-18 64.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ94690.1 - 0.0061 15.9 0.2 0.009 15.3 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ94690.1 - 0.016 14.2 0.1 0.027 13.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ94690.1 - 0.017 14.8 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ94690.1 - 0.034 13.1 0.0 0.034 13.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like WaaY PF06176.6 ERZ94690.1 - 0.062 12.5 0.1 0.097 11.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ERZ94692.1 - 2.6e-34 118.4 0.0 3.3e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94692.1 - 3.1e-31 108.4 0.0 4e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ94692.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ94692.1 - 0.0015 17.6 0.1 0.0021 17.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ94692.1 - 0.0023 16.9 0.0 0.0032 16.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like PsbU PF06514.6 ERZ94692.1 - 0.012 15.4 0.1 0.093 12.5 0.0 2.3 2 1 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) DUF2235 PF09994.4 ERZ94693.1 - 4.1e-56 190.3 0.0 4.6e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ERZ94693.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Response_reg PF00072.19 ERZ94695.1 - 0.0097 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Methyltrans_RNA PF04452.9 ERZ94697.1 - 0.018 14.1 5.3 0.03 13.4 3.7 1.3 1 0 0 1 1 1 0 RNA methyltransferase BTV_NS2 PF04514.7 ERZ94697.1 - 0.13 11.0 4.1 0.17 10.7 2.9 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 OrfB_IS605 PF01385.14 ERZ94697.1 - 0.17 11.2 5.9 0.3 10.4 3.8 1.6 1 1 0 1 1 1 0 Probable transposase NmrA PF05368.8 ERZ94699.1 - 8.3e-30 103.7 0.1 9.7e-30 103.5 0.1 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ94699.1 - 3.7e-13 49.8 0.0 4.8e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ERZ94699.1 - 5.5e-08 31.8 0.0 7.3e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ERZ94699.1 - 9.2e-07 28.5 0.1 1.3e-06 27.9 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 ERZ94699.1 - 4.2e-06 26.7 0.0 5.6e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ94699.1 - 3.8e-05 23.4 0.0 5.5e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 ERZ94699.1 - 9.4e-05 21.5 0.1 0.00011 21.3 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase TrkA_N PF02254.13 ERZ94699.1 - 0.00014 21.8 0.1 0.00021 21.2 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_4 PF07993.7 ERZ94699.1 - 0.0013 17.7 0.0 0.0015 17.4 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein DapB_N PF01113.15 ERZ94699.1 - 0.0067 16.3 0.0 0.0092 15.9 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.15 ERZ94699.1 - 0.018 15.1 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.10 ERZ94699.1 - 0.022 13.6 0.0 0.027 13.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.12 ERZ94699.1 - 0.066 13.6 0.0 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF432 PF04254.8 ERZ94700.1 - 0.058 13.3 0.0 0.067 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF432) Orbi_VP5 PF00901.12 ERZ94701.1 - 0.18 9.9 2.4 0.21 9.7 1.2 1.4 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP5 DUF2963 PF11178.3 ERZ94702.1 - 0.46 9.9 5.7 0.45 9.9 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) ERG4_ERG24 PF01222.12 ERZ94704.1 - 1.4e-97 326.9 27.9 1.7e-97 326.6 19.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ICMT PF04140.9 ERZ94704.1 - 0.0085 16.2 0.2 0.0085 16.2 0.1 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ERZ94704.1 - 0.026 14.6 0.1 0.026 14.6 0.1 3.2 4 0 0 4 4 4 0 Phospholipid methyltransferase Histone PF00125.19 ERZ94705.1 - 3.1e-24 84.8 0.0 5.1e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ERZ94705.1 - 1.3e-06 28.4 0.0 2.2e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RdRP PF05183.7 ERZ94708.1 - 9.4e-178 592.5 0.1 1.2e-177 592.1 0.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Sel1 PF08238.7 ERZ94711.1 - 1.1e-14 54.5 2.0 2.8e-08 34.1 0.1 2.5 2 1 0 2 2 2 2 Sel1 repeat Sel1 PF08238.7 ERZ94712.1 - 5e-07 30.1 0.2 6.7e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Sel1 repeat TPR_11 PF13414.1 ERZ94712.1 - 0.0062 16.1 0.1 0.0072 15.9 0.0 1.2 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 ERZ94712.1 - 0.0065 16.0 2.7 0.7 9.6 0.3 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ94712.1 - 0.081 13.1 1.0 0.66 10.3 0.5 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ94712.1 - 0.25 11.3 1.0 21 5.3 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat RNA_pol PF00940.14 ERZ94713.1 - 6.9e-160 531.9 7.0 1.3e-159 531.0 4.9 1.5 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 ERZ94713.1 - 1.6e-85 287.1 0.9 4.2e-85 285.8 0.1 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal DUF1186 PF06685.6 ERZ94715.1 - 0.0013 17.8 0.1 0.0015 17.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1186) PapD_C PF02753.12 ERZ94716.1 - 0.2 11.4 2.4 0.16 11.8 0.4 1.8 2 0 0 2 2 2 0 Pili assembly chaperone PapD, C-terminal domain N6_N4_Mtase PF01555.13 ERZ94718.1 - 7.4e-13 48.5 0.0 0.00012 21.6 0.0 3.4 3 1 0 3 3 3 3 DNA methylase Methyltransf_26 PF13659.1 ERZ94718.1 - 7.4e-11 42.1 0.0 3.1e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 ERZ94718.1 - 0.0012 18.4 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.2 ERZ94718.1 - 0.0081 16.7 0.0 0.037 14.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain EF-1_beta_acid PF10587.4 ERZ94718.1 - 0.019 15.0 1.6 0.044 13.9 1.1 1.7 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Methyltransf_11 PF08241.7 ERZ94718.1 - 0.049 14.1 0.0 0.75 10.3 0.0 2.8 3 1 0 3 3 3 0 Methyltransferase domain GATA PF00320.22 ERZ94718.1 - 0.058 12.7 0.9 0.12 11.7 0.6 1.5 1 0 0 1 1 1 0 GATA zinc finger SMC_N PF02463.14 ERZ94719.1 - 2.2e-25 89.2 25.5 4e-25 88.3 17.7 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ERZ94719.1 - 3.9e-09 36.9 4.6 4.3e-09 36.7 1.7 2.0 1 1 1 2 2 2 1 AAA domain Sulfatase_C PF14707.1 ERZ94719.1 - 0.011 16.0 2.6 0.011 16.0 1.8 3.1 2 1 0 3 3 3 0 C-terminal region of aryl-sulfatase DUF4611 PF15387.1 ERZ94719.1 - 0.4 10.8 15.6 1.2 9.3 0.8 3.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4611) MCM_N PF14551.1 ERZ94719.1 - 1.4 9.4 13.7 0.42 11.1 4.3 2.6 2 1 0 2 2 2 0 MCM N-terminal domain Reo_sigmaC PF04582.7 ERZ94719.1 - 3.2 6.8 16.8 0.82 8.7 1.7 2.7 2 1 1 3 3 3 0 Reovirus sigma C capsid protein SMC_hinge PF06470.8 ERZ94720.1 - 3.1e-26 91.7 0.1 1e-25 90.0 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.14 ERZ94720.1 - 9.6e-06 24.9 17.5 5.6e-05 22.4 12.1 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain CENP-Q PF13094.1 ERZ94720.1 - 0.0088 16.0 7.9 0.0088 16.0 5.5 3.8 3 0 0 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit Reo_sigmaC PF04582.7 ERZ94720.1 - 0.03 13.5 8.3 0.099 11.7 0.4 2.8 3 0 0 3 3 3 0 Reovirus sigma C capsid protein DUF711 PF05167.7 ERZ94720.1 - 0.33 9.6 3.6 0.66 8.6 2.5 1.4 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) Laminin_II PF06009.7 ERZ94720.1 - 0.54 10.0 37.4 0.053 13.2 6.3 4.8 4 2 1 5 5 5 0 Laminin Domain II DUF2389 PF09493.5 ERZ94720.1 - 1.8 8.8 4.7 0.99 9.7 0.0 3.2 3 0 0 3 3 3 0 Tryptophan-rich protein (DUF2389) zf-CHY PF05495.7 ERZ94721.1 - 2.9e-13 49.7 20.8 3.8e-13 49.3 14.4 1.1 1 0 0 1 1 1 1 CHY zinc finger DRP PF06044.7 ERZ94721.1 - 0.025 13.5 2.0 0.028 13.4 1.4 1.2 1 0 0 1 1 1 0 Dam-replacing family zinc_ribbon_2 PF13240.1 ERZ94721.1 - 0.076 12.5 0.2 0.076 12.5 0.1 3.2 2 1 0 2 2 2 0 zinc-ribbon domain C1_4 PF07975.7 ERZ94721.1 - 0.26 11.3 15.1 0.18 11.8 4.2 2.7 1 1 2 3 3 3 0 TFIIH C1-like domain Zn_Tnp_IS1595 PF12760.2 ERZ94721.1 - 0.34 10.7 11.1 11 5.8 5.5 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Cytochrome_C7 PF14522.1 ERZ94721.1 - 1.2 8.8 13.1 1.9 8.1 9.1 1.4 1 0 0 1 1 1 0 Cytochrome c7 DUF3797 PF12677.2 ERZ94721.1 - 1.2 8.8 0.1 1.2 8.8 0.0 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF3797) Zn-ribbon_8 PF09723.5 ERZ94721.1 - 5.2 7.1 17.3 0.54 10.2 5.2 2.6 2 1 0 2 2 2 0 Zinc ribbon domain Inhibitor_I78 PF11720.3 ERZ94722.1 - 1.2e-10 40.9 0.0 2.5e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.13 ERZ94722.1 - 0.0016 18.5 0.3 0.074 13.2 0.0 2.0 1 1 1 2 2 2 2 Potato inhibitor I family DUF2235 PF09994.4 ERZ94723.1 - 7e-11 42.0 0.0 8.2e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) IN_DBD_C PF00552.16 ERZ94724.1 - 0.054 12.9 0.6 25 4.4 0.0 3.6 3 1 1 4 4 4 0 Integrase DNA binding domain Ribosomal_S13 PF00416.17 ERZ94724.1 - 0.17 12.3 3.3 5.1 7.5 0.3 2.1 1 1 1 2 2 2 0 Ribosomal protein S13/S18 DUF2235 PF09994.4 ERZ94725.1 - 8.1e-58 195.9 0.0 1e-57 195.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) HTH_Tnp_Tc5 PF03221.11 ERZ94726.1 - 8.2e-10 38.3 0.1 1.5e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_26 PF13443.1 ERZ94726.1 - 0.02 15.0 0.2 0.55 10.4 0.0 2.3 1 1 1 2 2 2 0 Cro/C1-type HTH DNA-binding domain Dymeclin PF09742.4 ERZ94726.1 - 0.053 11.6 0.2 0.055 11.5 0.1 1.0 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein DDE_1 PF03184.14 ERZ94727.1 - 4e-11 42.4 0.0 4.2e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Ebola_NP PF05505.7 ERZ94727.1 - 0.12 10.3 0.0 0.12 10.3 0.0 1.0 1 0 0 1 1 1 0 Ebola nucleoprotein DUF3455 PF11937.3 ERZ94728.1 - 0.11 12.4 0.2 0.14 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) Endonuclease_7 PF02945.10 ERZ94729.1 - 0.024 14.3 0.8 0.058 13.1 0.6 1.7 1 0 0 1 1 1 0 Recombination endonuclease VII DUF2235 PF09994.4 ERZ94730.1 - 5.3e-59 199.8 0.0 6.5e-59 199.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ERZ94730.1 - 0.042 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2235 PF09994.4 ERZ94731.1 - 6.7e-64 215.9 0.0 8.4e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ERZ94731.1 - 0.024 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2235 PF09994.4 ERZ94732.1 - 8.9e-14 51.5 0.0 1.3e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF2235 PF09994.4 ERZ94733.1 - 8.9e-17 61.3 0.0 1.3e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) OST3_OST6 PF04756.8 ERZ94735.1 - 0.049 13.1 3.9 0.057 12.9 2.7 1.1 1 0 0 1 1 1 0 OST3 / OST6 family DUF2238 PF09997.4 ERZ94735.1 - 0.2 11.0 3.1 0.38 10.1 2.2 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2238) ABC2_membrane_4 PF12730.2 ERZ94735.1 - 3.5 6.7 15.0 5.5 6.0 10.4 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF3784 PF12650.2 ERZ94735.1 - 9 6.3 9.1 17 5.4 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF843 PF05814.6 ERZ94735.1 - 9.1 6.1 6.4 1.4 8.8 1.2 1.9 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) zf-TFIIB PF13453.1 ERZ94736.1 - 0.034 13.3 0.6 0.49 9.6 0.1 2.5 2 1 0 2 2 2 0 Transcription factor zinc-finger HTH_23 PF13384.1 ERZ94737.1 - 4.7e-05 22.8 0.0 6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ERZ94737.1 - 0.00018 21.6 0.0 0.00019 21.5 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 ERZ94737.1 - 0.00057 19.8 0.1 0.00073 19.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.1 ERZ94737.1 - 0.0011 18.4 0.1 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_IS630 PF01710.11 ERZ94737.1 - 0.026 14.2 0.2 0.031 13.9 0.1 1.1 1 0 0 1 1 1 0 Transposase MACPF PF01823.14 ERZ94738.1 - 3.6e-06 26.8 5.0 3.6e-06 26.8 3.5 2.1 2 1 0 2 2 2 1 MAC/Perforin domain RRM_3 PF08777.6 ERZ94738.1 - 0.059 13.2 1.6 0.25 11.2 1.1 2.1 1 0 0 1 1 1 0 RNA binding motif DUF1794 PF08768.6 ERZ94738.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1794) Pkinase_Tyr PF07714.12 ERZ94739.1 - 1.8e-30 105.9 0.9 2.7e-30 105.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94739.1 - 1.7e-29 102.8 1.1 1.7e-29 102.8 0.7 1.4 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ERZ94739.1 - 0.034 13.8 0.5 0.051 13.2 0.3 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Zn-ribbon_8 PF09723.5 ERZ94739.1 - 0.38 10.7 2.4 0.88 9.5 1.7 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF2283 PF10049.4 ERZ94740.1 - 0.00085 19.1 0.2 0.044 13.6 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2283) DNA_pol_B_exo1 PF03104.14 ERZ94741.1 - 3.5e-14 52.3 0.9 4.9e-14 51.9 0.6 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Pkinase_Tyr PF07714.12 ERZ94742.1 - 0.0014 17.7 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Poxvirus PF06227.7 ERZ94742.1 - 0.037 13.5 1.5 0.043 13.3 1.1 1.2 1 0 0 1 1 1 0 dsDNA Poxvirus Sugar_tr PF00083.19 ERZ94744.1 - 1.6e-135 452.1 16.8 1.9e-135 451.9 11.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ERZ94744.1 - 9.3e-31 106.8 32.0 1.6e-20 73.1 7.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 ERZ94744.1 - 0.00026 19.3 1.4 0.00026 19.3 0.9 2.0 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DUF441 PF04284.8 ERZ94744.1 - 0.023 14.5 1.2 0.023 14.5 0.8 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF441) Peptidase_S28 PF05577.7 ERZ94747.1 - 8e-87 291.6 0.0 9.2e-87 291.3 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.15 ERZ94747.1 - 5.4e-05 22.8 0.0 8.2e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ERZ94747.1 - 0.0003 20.7 0.0 0.00044 20.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.6 ERZ94747.1 - 0.0003 19.3 0.0 0.00093 17.7 0.0 1.6 2 0 0 2 2 2 1 PS-10 peptidase S37 DUF2920 PF11144.3 ERZ94747.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Peptidase_S9 PF00326.16 ERZ94747.1 - 0.082 12.1 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Gelsolin PF00626.17 ERZ94748.1 - 8.4e-42 140.7 0.4 2.5e-14 52.7 0.0 3.4 4 0 0 4 4 4 3 Gelsolin repeat Velvet PF11754.3 ERZ94750.1 - 5.6e-16 58.7 1.4 8.8e-16 58.1 0.1 2.0 2 0 0 2 2 2 1 Velvet factor PH PF00169.24 ERZ94751.1 - 6e-11 42.4 0.9 3.9e-10 39.8 0.1 2.9 2 0 0 2 2 2 1 PH domain NTP_transferase PF00483.18 ERZ94751.1 - 7.5e-06 25.4 0.0 3.2e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase GRAM PF02893.15 ERZ94751.1 - 0.00016 21.1 0.1 0.00039 19.8 0.1 1.7 1 0 0 1 1 1 1 GRAM domain NTP_transf_3 PF12804.2 ERZ94751.1 - 0.00051 20.1 0.0 0.00088 19.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 ERZ94752.1 - 7e-08 32.0 0.2 1.2e-06 28.0 0.0 2.3 1 1 1 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 ERZ94752.1 - 1.9e-05 24.7 0.0 2.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Imm21 PF15569.1 ERZ94752.1 - 0.037 13.7 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 21 Aminotran_4 PF01063.14 ERZ94753.1 - 9.1e-12 44.9 0.0 1.1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Hydantoinase_B PF02538.9 ERZ94755.1 - 0.00099 17.4 1.2 0.0011 17.3 0.9 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase JHBP PF06585.6 ERZ94755.1 - 0.0073 15.1 1.4 0.0087 14.9 1.0 1.1 1 0 0 1 1 1 1 Haemolymph juvenile hormone binding protein (JHBP) M11L PF11099.3 ERZ94755.1 - 0.027 14.2 2.3 0.031 14.0 1.6 1.0 1 0 0 1 1 1 0 Apoptosis regulator M11L like DUF2294 PF10057.4 ERZ94755.1 - 0.044 13.4 0.7 0.048 13.3 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Sec5 PF15469.1 ERZ94755.1 - 0.069 12.8 1.5 0.067 12.9 1.0 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec5 Dimer_Tnp_hAT PF05699.9 ERZ94756.1 - 1.7e-21 75.5 0.2 2e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Plug_translocon PF10559.4 ERZ94756.1 - 0.038 13.4 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Plug domain of Sec61p Scs3p PF10261.4 ERZ94757.1 - 1.3e-49 168.4 25.3 1e-48 165.5 17.6 2.1 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Rhomboid PF01694.17 ERZ94757.1 - 0.018 15.1 2.8 0.018 15.1 1.9 2.3 3 0 0 3 3 3 0 Rhomboid family PAP2 PF01569.16 ERZ94757.1 - 4.2 7.0 18.9 0.52 9.9 8.8 2.3 1 1 1 2 2 2 0 PAP2 superfamily Acid_PPase PF12689.2 ERZ94758.1 - 3.2e-53 179.8 0.0 5.2e-53 179.1 0.0 1.3 1 1 0 1 1 1 1 Acid Phosphatase HAD_2 PF13419.1 ERZ94758.1 - 0.024 14.8 0.7 3.3 7.8 0.0 2.8 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase RVT_3 PF13456.1 ERZ94759.1 - 0.045 13.5 0.4 0.79 9.5 0.0 2.2 2 0 0 2 2 2 0 Reverse transcriptase-like TPR_8 PF13181.1 ERZ94759.1 - 0.57 10.1 3.9 0.34 10.7 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ94759.1 - 7.2 6.4 6.7 12 5.6 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_3_Rpc31 PF11705.3 ERZ94760.1 - 4.7e-20 72.5 10.4 5.9e-20 72.2 7.2 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Myb_DNA-binding PF00249.26 ERZ94761.1 - 0.0018 18.2 0.0 0.0039 17.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain IATP PF04568.7 ERZ94762.1 - 1.8e-13 50.3 0.3 2e-13 50.1 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP FbpA PF05833.6 ERZ94762.1 - 0.0014 17.2 1.5 0.0015 17.1 1.1 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NYD-SP28 PF14772.1 ERZ94762.1 - 0.0049 16.9 6.1 0.0063 16.5 4.2 1.2 1 0 0 1 1 1 1 Sperm tail Fib_alpha PF08702.5 ERZ94762.1 - 0.02 15.0 0.4 0.023 14.8 0.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family IncA PF04156.9 ERZ94762.1 - 0.039 13.5 1.9 0.039 13.5 1.3 1.1 1 0 0 1 1 1 0 IncA protein YgaB PF14182.1 ERZ94762.1 - 0.05 13.8 5.0 0.076 13.2 3.4 1.3 1 0 0 1 1 1 0 YgaB-like protein Atg14 PF10186.4 ERZ94762.1 - 0.069 12.0 2.3 0.065 12.1 1.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1212 PF06738.7 ERZ94762.1 - 0.14 11.6 0.8 0.19 11.1 0.2 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) RBD-FIP PF09457.5 ERZ94762.1 - 0.36 10.6 3.9 0.73 9.6 2.7 1.6 1 0 0 1 1 1 0 FIP domain SlyX PF04102.7 ERZ94762.1 - 0.51 10.7 3.5 0.37 11.1 1.2 1.8 2 0 0 2 2 2 0 SlyX FlxA PF14282.1 ERZ94762.1 - 1.2 9.1 8.8 2.5 8.1 5.9 1.6 1 1 1 2 2 2 0 FlxA-like protein DUF4315 PF14193.1 ERZ94762.1 - 4 7.4 12.7 2.4 8.1 7.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) DivIC PF04977.10 ERZ94762.1 - 5.5 6.5 7.8 8.2 6.0 5.4 1.3 1 0 0 1 1 1 0 Septum formation initiator eIF2A PF08662.6 ERZ94763.1 - 1.2e-42 145.8 7.2 1.3e-39 135.9 0.6 5.4 3 3 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 ERZ94763.1 - 4e-05 23.1 0.0 9.2e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ94763.1 - 0.00039 20.1 0.0 0.00097 18.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 ERZ94763.1 - 0.0004 20.1 0.4 0.37 10.7 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat RRM_6 PF14259.1 ERZ94763.1 - 0.00085 19.2 0.0 0.0023 17.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SNF5 PF04855.7 ERZ94764.1 - 3.9e-62 209.8 7.3 6.3e-60 202.6 5.1 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.22 ERZ94764.1 - 5e-11 41.7 1.4 9.8e-11 40.8 1.0 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF4379 PF14311.1 ERZ94764.1 - 0.74 9.6 3.4 2.8 7.8 1.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4379) DUF2183 PF09949.4 ERZ94766.1 - 3.5e-32 110.3 0.1 8.1e-32 109.1 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.8 ERZ94766.1 - 0.026 14.0 0.0 0.064 12.8 0.0 1.7 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) DUF3465 PF11948.3 ERZ94766.1 - 0.094 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) DUF2457 PF10446.4 ERZ94766.1 - 9.3 4.8 15.4 0.23 10.1 5.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Gar1 PF04410.9 ERZ94768.1 - 8.5e-42 142.2 0.0 1e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region G6PD_C PF02781.11 ERZ94769.1 - 1.3e-116 388.5 0.0 1.6e-115 385.0 0.0 2.2 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 ERZ94769.1 - 2.4e-61 207.1 0.0 3.4e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Chlorophyllase2 PF12740.2 ERZ94769.1 - 0.2 10.4 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme TMP PF05017.9 ERZ94773.1 - 0.059 13.7 0.5 0.21 12.1 0.1 2.1 2 0 0 2 2 2 0 TMP repeat DapH_N PF08503.5 ERZ94773.1 - 0.12 12.4 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal Piwi PF02171.12 ERZ94775.1 - 3.1e-99 331.7 0.1 5.2e-99 331.0 0.1 1.4 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ94775.1 - 2.5e-26 91.5 1.5 5e-26 90.5 1.1 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ94775.1 - 1.3e-15 56.4 0.0 2.6e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Piwi PF02171.12 ERZ94776.1 - 2.2e-99 332.2 0.0 3.1e-99 331.7 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ94776.1 - 5.9e-26 90.3 1.0 1.4e-25 89.1 0.7 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ94776.1 - 1.9e-15 55.9 0.0 4.3e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Piwi PF02171.12 ERZ94777.1 - 5.9e-97 324.2 0.0 1.9e-96 322.6 0.0 1.7 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.17 ERZ94777.1 - 7.9e-27 93.2 0.9 1.6e-26 92.2 0.7 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ94777.1 - 6.4e-15 54.2 0.0 1.4e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) RNase_H PF00075.19 ERZ94780.1 - 0.00061 20.1 0.3 0.0015 18.9 0.2 1.7 1 0 0 1 1 1 1 RNase H RE_ApaLI PF09499.5 ERZ94780.1 - 0.019 14.3 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 ApaLI-like restriction endonuclease PIF1 PF05970.9 ERZ94781.1 - 3.9e-09 35.9 0.1 2.7e-06 26.5 0.0 2.0 1 1 1 2 2 2 2 PIF1-like helicase FAR1 PF03101.10 ERZ94782.1 - 2.2e-05 24.8 1.1 3.8e-05 24.1 0.7 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ERZ94782.1 - 0.07 12.7 1.2 1.7 8.3 0.8 2.3 1 1 0 1 1 1 0 MuDR family transposase Ribosomal_L33 PF00471.15 ERZ94782.1 - 0.72 10.1 3.7 0.27 11.4 0.5 1.8 2 0 0 2 2 2 0 Ribosomal protein L33 DUF1129 PF06570.6 ERZ94783.1 - 0.05 12.9 2.5 0.076 12.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Chromo PF00385.19 ERZ94784.1 - 2.1e-13 49.7 2.1 1.1e-12 47.4 0.2 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF912 PF06024.7 ERZ94785.1 - 1.3 9.1 3.5 1.5 8.9 2.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-C2H2 PF00096.21 ERZ94786.1 - 0.00068 19.8 0.9 0.00068 19.8 0.6 3.0 4 1 1 5 5 5 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ERZ94786.1 - 0.013 15.3 0.3 0.013 15.3 0.2 2.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-FCS PF06467.9 ERZ94786.1 - 0.013 15.0 3.2 0.017 14.7 1.0 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 PF13894.1 ERZ94786.1 - 0.016 15.4 1.8 0.016 15.4 1.2 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 ERZ94786.1 - 0.096 12.9 0.2 0.096 12.9 0.2 3.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Pox_vIL-18BP PF05566.7 ERZ94786.1 - 0.12 12.3 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein zf-C2H2_jaz PF12171.3 ERZ94786.1 - 0.13 12.4 3.2 0.21 11.7 0.7 2.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MitMem_reg PF13012.1 ERZ94787.1 - 2.5e-23 82.3 0.0 3.8e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 ERZ94787.1 - 2.5e-18 65.8 0.0 4.4e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4606 PF15379.1 ERZ94787.1 - 0.085 12.9 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) GAT PF03127.9 ERZ94787.1 - 0.11 12.4 0.1 0.37 10.8 0.0 1.8 2 0 0 2 2 2 0 GAT domain Arfaptin PF06456.8 ERZ94788.1 - 0.023 14.0 0.4 0.032 13.5 0.3 1.4 1 1 0 1 1 1 0 Arfaptin-like domain Rep_4 PF05797.6 ERZ94788.1 - 0.025 13.2 1.0 0.028 13.1 0.7 1.0 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) GP41 PF00517.12 ERZ94788.1 - 0.099 12.1 1.7 0.11 12.0 1.1 1.1 1 0 0 1 1 1 0 Retroviral envelope protein Tweety PF04906.8 ERZ94788.1 - 0.13 10.6 0.4 0.14 10.5 0.3 1.0 1 0 0 1 1 1 0 Tweety DASH_Dad1 PF08649.5 ERZ94788.1 - 0.21 11.3 2.1 3.3 7.4 0.1 2.4 1 1 0 2 2 2 0 DASH complex subunit Dad1 DUF2207 PF09972.4 ERZ94790.1 - 0.44 9.0 5.8 0.53 8.8 4.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) F-box-like PF12937.2 ERZ94791.1 - 0.014 15.1 1.0 0.041 13.6 0.3 2.2 2 0 0 2 2 2 0 F-box-like RNase_H PF00075.19 ERZ94792.1 - 7.3e-13 49.0 0.0 1e-12 48.5 0.0 1.2 1 0 0 1 1 1 1 RNase H Lipase_GDSL_2 PF13472.1 ERZ94795.1 - 9e-21 74.7 0.0 1e-20 74.6 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ERZ94795.1 - 8.4e-13 48.6 0.1 2.9e-12 46.9 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase NPDC1 PF06809.6 ERZ94796.1 - 0.33 9.7 0.9 0.64 8.7 0.6 1.4 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) AAA_12 PF13087.1 ERZ94797.1 - 1e-41 142.5 0.0 2.1e-41 141.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ERZ94797.1 - 2.8e-27 95.8 0.5 8.5e-27 94.2 0.4 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 ERZ94797.1 - 1.6e-09 37.6 0.0 3e-07 30.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ERZ94797.1 - 3.5e-08 33.0 0.0 7.7e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ERZ94797.1 - 7.6e-06 25.1 0.1 0.00071 18.6 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 ERZ94797.1 - 3.4e-05 23.7 0.1 8.2e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ERZ94797.1 - 0.0044 17.0 0.3 0.19 11.7 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain PhoH PF02562.11 ERZ94797.1 - 0.0047 16.1 0.0 0.019 14.1 0.0 1.9 2 0 0 2 2 2 1 PhoH-like protein AAA_18 PF13238.1 ERZ94797.1 - 0.01 16.1 0.9 0.033 14.5 0.0 2.4 2 0 0 2 2 1 0 AAA domain Helicase_RecD PF05127.9 ERZ94797.1 - 0.053 13.1 0.0 0.77 9.3 0.0 2.4 2 0 0 2 2 2 0 Helicase AAA_22 PF13401.1 ERZ94797.1 - 0.055 13.6 0.5 2.8 8.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.1 ERZ94797.1 - 1.2 9.9 4.6 2.2 9.1 0.0 3.4 1 1 0 2 2 2 0 AAA domain Reo_sigmaC PF04582.7 ERZ94798.1 - 4.3 6.4 14.4 2.6 7.1 4.5 2.5 1 1 0 2 2 2 0 Reovirus sigma C capsid protein V_ATPase_I PF01496.14 ERZ94798.1 - 9.1 3.9 34.4 1.3 6.7 5.5 2.7 2 1 1 3 3 3 0 V-type ATPase 116kDa subunit family RNase_H PF00075.19 ERZ94799.1 - 3.1e-21 76.0 0.0 5.8e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-Mss51 PF13824.1 ERZ94800.1 - 9.5e-18 63.8 8.7 1.7e-17 62.9 6.0 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 OrfB_Zn_ribbon PF07282.6 ERZ94800.1 - 0.39 10.4 3.5 0.32 10.6 1.1 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-MYND PF01753.13 ERZ94800.1 - 0.65 9.9 5.9 1.2 9.1 4.1 1.4 1 0 0 1 1 1 0 MYND finger zf-HIT PF04438.11 ERZ94800.1 - 1.2 8.8 6.7 3 7.5 4.7 1.7 1 1 0 1 1 1 0 HIT zinc finger Epimerase PF01370.16 ERZ94801.1 - 1.3e-59 201.5 0.0 1.6e-59 201.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ERZ94801.1 - 6.2e-24 84.4 0.0 5.3e-23 81.3 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 ERZ94801.1 - 1.3e-23 83.2 1.3 1.4e-22 79.8 0.9 2.0 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 ERZ94801.1 - 1.7e-23 82.7 0.0 2.1e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 ERZ94801.1 - 4.8e-22 78.1 0.0 9.1e-22 77.2 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 ERZ94801.1 - 6.5e-07 29.5 0.2 7.1e-06 26.1 0.1 2.0 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ERZ94801.1 - 0.00092 19.1 0.1 0.0062 16.4 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ERZ94801.1 - 0.15 11.6 0.5 0.74 9.4 0.4 2.0 1 1 0 1 1 1 0 KR domain RNA_pol_L_2 PF13656.1 ERZ94802.1 - 3.5e-27 93.6 0.1 4.7e-27 93.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 ERZ94802.1 - 6.6e-10 37.9 0.0 1.2e-09 37.1 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain CENP-X PF09415.5 ERZ94803.1 - 5.1e-11 42.2 0.0 6.4e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Histone PF00125.19 ERZ94804.1 - 9.4e-32 108.9 0.4 1.4e-31 108.3 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ERZ94804.1 - 7.3e-06 26.0 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ERZ94804.1 - 0.0015 18.5 0.1 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ERZ94804.1 - 0.0038 16.9 0.1 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated CENP-T PF15511.1 ERZ94804.1 - 0.14 11.3 1.1 0.22 10.7 0.8 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T Arch_ATPase PF01637.13 ERZ94807.1 - 2.1e-11 43.9 0.6 3.3e-11 43.3 0.4 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ERZ94807.1 - 1e-05 25.6 0.1 4.7e-05 23.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ94807.1 - 8.5e-05 22.7 0.1 0.00033 20.8 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ERZ94807.1 - 0.0065 17.2 0.2 0.026 15.3 0.2 2.2 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ERZ94807.1 - 0.019 15.1 0.1 3.2 7.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.7 ERZ94807.1 - 0.036 13.7 0.0 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 NACHT domain HTH_AsnC-type PF13404.1 ERZ94807.1 - 0.059 12.9 0.4 0.11 12.0 0.3 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain AAA_5 PF07728.9 ERZ94807.1 - 0.06 13.0 0.0 10 5.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ERZ94807.1 - 0.13 11.3 0.0 0.26 10.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 ERZ94807.1 - 0.16 11.9 0.0 1 9.3 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 ERZ94807.1 - 0.17 11.8 2.4 8.3 6.3 1.7 2.4 1 1 0 1 1 1 0 AAA domain Myb_DNA-bind_6 PF13921.1 ERZ94808.1 - 1.6e-13 50.5 13.0 6.4e-10 38.9 0.8 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ERZ94808.1 - 1.2e-10 41.3 3.1 4e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 ERZ94808.1 - 0.0053 16.5 0.6 0.039 13.7 0.4 2.3 1 1 0 1 1 1 1 Rap1 Myb domain Myb_DNA-bind_4 PF13837.1 ERZ94808.1 - 0.028 14.5 14.5 17 5.6 9.7 3.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain HTH_23 PF13384.1 ERZ94808.1 - 0.053 13.1 0.4 12 5.6 0.1 2.4 2 0 0 2 2 2 0 Homeodomain-like domain DnaG_DnaB_bind PF08278.6 ERZ94808.1 - 0.054 13.7 0.5 0.1 12.8 0.3 1.4 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding DUF4313 PF14190.1 ERZ94808.1 - 0.085 12.5 0.6 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4313) Dioxygenase_N PF04444.9 ERZ94808.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Myb_DNA-bind_5 PF13873.1 ERZ94808.1 - 0.43 10.5 15.3 2.2 8.2 5.0 3.3 2 2 1 3 3 3 0 Myb/SANT-like DNA-binding domain 2OG-Fe_Oxy_2 PF10014.4 ERZ94808.1 - 0.48 9.7 3.3 0.47 9.8 1.1 1.7 2 0 0 2 2 2 0 2OG-Fe dioxygenase Glyco_hydro_65m PF03632.10 ERZ94808.1 - 2.8 6.5 6.5 1.2 7.7 1.7 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 65 central catalytic domain FAD_binding_3 PF01494.14 ERZ94810.1 - 4.5e-15 55.5 0.0 2.3e-10 40.0 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 ERZ94810.1 - 0.00017 21.5 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ERZ94810.1 - 0.00037 20.3 0.0 0.00092 19.0 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ERZ94810.1 - 0.0028 17.7 0.0 0.0064 16.5 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ERZ94810.1 - 0.17 10.7 0.0 0.28 10.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Muskelin_N PF06588.6 ERZ94811.1 - 1e-79 266.8 3.5 1.5e-79 266.2 2.4 1.2 1 0 0 1 1 1 1 Muskelin N-terminus Kelch_3 PF13415.1 ERZ94811.1 - 4e-27 93.6 3.4 2.9e-07 30.4 0.2 7.7 8 0 0 8 8 8 6 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ94811.1 - 1.2e-22 79.0 3.3 0.0027 17.8 0.2 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ERZ94811.1 - 1.3e-20 72.9 11.1 3.3e-05 23.5 0.8 7.3 6 1 1 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ERZ94811.1 - 1.9e-19 68.9 9.7 8.2e-05 22.0 0.5 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ERZ94811.1 - 1e-18 66.8 9.8 3.7e-05 23.5 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ERZ94811.1 - 1.1e-06 28.1 6.8 0.066 13.0 0.3 6.0 6 0 0 6 6 6 2 Kelch motif F5_F8_type_C PF00754.20 ERZ94811.1 - 0.0059 16.4 0.0 0.017 14.9 0.0 1.9 1 0 0 1 1 1 1 F5/8 type C domain DUF1374 PF07118.6 ERZ94811.1 - 0.13 12.3 0.1 0.13 12.3 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1374) zf-U1 PF06220.7 ERZ94812.1 - 5.8e-10 38.5 4.2 1.8e-09 36.9 2.9 1.9 1 0 0 1 1 1 1 U1 zinc finger zf-CCCH PF00642.19 ERZ94812.1 - 8.3e-08 31.7 1.7 1.5e-07 30.8 1.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_jaz PF12171.3 ERZ94812.1 - 0.03 14.4 5.9 0.091 12.9 2.8 2.8 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ERZ94812.1 - 0.054 13.8 3.1 0.17 12.2 0.5 2.7 2 1 1 3 3 3 0 C2H2-type zinc finger eIF-5_eIF-2B PF01873.12 ERZ94813.1 - 2.2e-40 137.1 0.0 5.3e-40 135.9 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 ERZ94813.1 - 3.5e-14 52.5 5.5 1.7e-12 47.1 3.8 2.8 1 1 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DUF2207 PF09972.4 ERZ94814.1 - 0.043 12.4 0.2 0.046 12.3 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ABC2_membrane_4 PF12730.2 ERZ94814.1 - 0.053 12.6 7.8 0.068 12.3 5.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein FA_hydroxylase PF04116.8 ERZ94814.1 - 0.16 12.4 1.6 0.23 11.8 1.1 1.2 1 0 0 1 1 1 0 Fatty acid hydroxylase superfamily DUF1517 PF07466.6 ERZ94814.1 - 0.26 10.2 2.4 0.34 9.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) DUF2407_C PF13373.1 ERZ94814.1 - 0.82 9.5 3.9 1.5 8.7 1.5 2.0 2 0 0 2 2 2 0 DUF2407 C-terminal domain MAT_Alpha1 PF04769.7 ERZ94815.1 - 0.03 13.6 0.1 0.069 12.4 0.0 1.6 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 NUC194 PF08163.7 ERZ94816.1 - 2.1e-64 217.8 1.1 2.1e-64 217.8 0.8 2.2 2 1 0 2 2 2 1 NUC194 domain PI3_PI4_kinase PF00454.22 ERZ94816.1 - 1.1e-42 146.1 0.5 4.1e-42 144.2 0.4 2.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.18 ERZ94816.1 - 1.4e-15 57.1 11.5 1.8e-14 53.4 7.9 2.4 1 1 0 1 1 1 1 FAT domain FATC PF02260.15 ERZ94816.1 - 3.1e-10 39.2 1.9 4.2e-10 38.8 0.2 2.1 2 0 0 2 2 2 1 FATC domain HEAT PF02985.17 ERZ94816.1 - 0.019 14.9 1.5 40 4.6 0.0 5.6 6 0 0 6 6 6 0 HEAT repeat Dicer_dimer PF03368.9 ERZ94817.1 - 0.056 13.2 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 Dicer dimerisation domain OGG_N PF07934.7 ERZ94817.1 - 0.12 12.3 0.1 0.21 11.5 0.1 1.6 1 1 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain DUF2457 PF10446.4 ERZ94818.1 - 0.028 13.1 7.5 0.029 13.1 5.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF1436 PF07262.6 ERZ94818.1 - 0.037 13.5 2.2 0.048 13.1 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) eIF-3c_N PF05470.7 ERZ94818.1 - 0.038 12.0 2.5 0.038 12.0 1.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF4611 PF15387.1 ERZ94818.1 - 0.15 12.2 3.9 0.2 11.8 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Nucleoplasmin PF03066.10 ERZ94818.1 - 0.26 10.7 6.7 0.36 10.3 4.7 1.2 1 0 0 1 1 1 0 Nucleoplasmin DUF3295 PF11702.3 ERZ94818.1 - 0.37 9.7 4.3 0.38 9.6 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) RXT2_N PF08595.6 ERZ94818.1 - 0.81 9.4 4.6 1.2 8.9 3.2 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal FAD_binding_3 PF01494.14 ERZ94820.1 - 2.8e-05 23.3 0.0 0.6 9.0 0.0 3.2 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ERZ94820.1 - 0.00035 20.5 0.0 0.00071 19.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ERZ94820.1 - 0.00088 19.0 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ERZ94820.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ERZ94820.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF1548 PF07579.6 ERZ94821.1 - 0.034 14.2 0.0 0.044 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) tRNA_anti-codon PF01336.20 ERZ94825.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.3 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain dNK PF01712.14 ERZ94827.1 - 8.7e-16 58.1 6.4 8.7e-16 58.1 4.4 2.9 2 2 0 2 2 2 1 Deoxynucleoside kinase AAA_18 PF13238.1 ERZ94827.1 - 2.5e-08 34.2 5.8 2.5e-08 34.2 4.1 2.0 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ERZ94827.1 - 3.4e-07 31.1 0.1 1.1e-06 29.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ERZ94827.1 - 1.3e-06 28.4 0.0 1.9e-06 27.9 0.0 1.3 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 ERZ94827.1 - 0.00023 20.5 4.0 0.00084 18.7 2.8 2.0 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.1 ERZ94827.1 - 0.00054 19.8 0.0 0.0012 18.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain Coiled-coil_56 PF09813.4 ERZ94827.1 - 0.00095 19.1 2.4 0.065 13.2 0.1 2.5 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 56 Herpes_TK PF00693.13 ERZ94827.1 - 0.0028 16.8 0.1 0.81 8.8 0.0 2.2 1 1 1 2 2 2 2 Thymidine kinase from herpesvirus MoCF_biosynth PF00994.19 ERZ94827.1 - 0.0073 15.7 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Probable molybdopterin binding domain AAA_22 PF13401.1 ERZ94827.1 - 0.011 15.9 0.5 0.14 12.3 0.1 2.6 2 1 1 3 3 3 0 AAA domain DUF258 PF03193.11 ERZ94827.1 - 0.014 14.5 0.3 0.028 13.6 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 ERZ94827.1 - 0.023 14.6 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_26 PF13500.1 ERZ94827.1 - 0.053 13.1 0.3 0.39 10.2 0.1 2.3 2 1 1 3 3 3 0 AAA domain RVT_1 PF00078.22 ERZ94828.1 - 1.5e-06 27.7 0.4 0.00046 19.5 0.0 2.8 2 1 0 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) Erf4 PF10256.4 ERZ94828.1 - 0.0063 16.3 2.0 0.31 10.9 0.0 3.1 3 0 0 3 3 3 1 Golgin subfamily A member 7/ERF4 family DUF2252 PF10009.4 ERZ94828.1 - 0.037 12.9 1.1 0.13 11.1 0.7 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF45 PF01863.12 ERZ94828.1 - 0.085 12.6 7.7 0.69 9.6 2.4 2.7 3 0 0 3 3 3 0 Protein of unknown function DUF45 RhoGEF PF00621.15 ERZ94829.1 - 2.9e-26 92.4 0.6 2.9e-26 92.4 0.4 1.5 2 0 0 2 2 2 1 RhoGEF domain TLD PF07534.11 ERZ94830.1 - 2.4e-10 40.5 1.2 5.8e-10 39.3 0.8 1.6 1 1 0 1 1 1 1 TLD Glyco_hydro_18 PF00704.23 ERZ94830.1 - 0.026 13.9 1.6 0.029 13.8 1.1 1.3 1 1 0 1 1 1 0 Glycosyl hydrolases family 18 DUF2034 PF10356.4 ERZ94833.1 - 1.6e-23 82.7 0.3 1e-11 44.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 ERZ94833.1 - 9.5e-09 35.0 0.0 1.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease GATA PF00320.22 ERZ94835.1 - 4e-22 77.2 13.6 1.5e-12 46.6 2.3 2.2 2 0 0 2 2 2 2 GATA zinc finger RRN7 PF11781.3 ERZ94835.1 - 0.00015 21.1 6.4 0.02 14.4 0.4 2.4 2 0 0 2 2 2 2 RNA polymerase I-specific transcription initiation factor Rrn7 ArfGap PF01412.13 ERZ94835.1 - 0.00022 20.9 8.8 0.0038 16.9 0.7 2.1 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf Zn-ribbon_8 PF09723.5 ERZ94835.1 - 0.024 14.5 4.6 2 8.4 0.4 2.4 2 0 0 2 2 2 0 Zinc ribbon domain NMD3 PF04981.8 ERZ94835.1 - 0.027 13.5 7.5 0.68 9.0 1.0 2.0 1 1 1 2 2 2 0 NMD3 family FYVE PF01363.16 ERZ94835.1 - 0.037 13.9 11.0 0.12 12.3 1.9 2.3 1 1 1 2 2 2 0 FYVE zinc finger Ins145_P3_rec PF08709.6 ERZ94835.1 - 0.064 12.2 0.0 0.82 8.6 0.0 2.0 1 1 1 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DZR PF12773.2 ERZ94835.1 - 0.067 13.0 11.6 14 5.6 8.2 3.1 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ERZ94835.1 - 0.31 10.5 2.3 18 5.0 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_6 PF14599.1 ERZ94835.1 - 0.38 10.5 10.7 1 9.2 2.7 2.8 2 2 0 2 2 2 0 Zinc-ribbon zf-CHY PF05495.7 ERZ94835.1 - 0.45 10.7 7.1 0.88 9.7 0.6 2.1 2 0 0 2 2 2 0 CHY zinc finger A2L_zn_ribbon PF08792.5 ERZ94835.1 - 0.51 9.8 0.0 0.51 9.8 0.0 3.5 4 1 0 4 4 4 0 A2L zinc ribbon domain zf-RING_5 PF14634.1 ERZ94835.1 - 1 9.1 9.4 3.2 7.5 1.5 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Cytochrom_c3_2 PF14537.1 ERZ94835.1 - 1.1 9.6 4.5 2 8.8 3.1 1.4 1 1 0 1 1 1 0 Cytochrome c3 zf-B_box PF00643.19 ERZ94835.1 - 1.9 8.4 13.2 18 5.2 0.0 4.0 4 0 0 4 4 4 0 B-box zinc finger zf-Sec23_Sec24 PF04810.10 ERZ94835.1 - 3.3 7.3 9.3 3.3 7.3 1.6 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger C1_3 PF07649.7 ERZ94835.1 - 5.3 7.1 11.7 2.6 8.1 0.1 2.9 3 0 0 3 3 2 0 C1-like domain LIM PF00412.17 ERZ94835.1 - 5.3 7.1 6.7 15 5.7 0.3 2.2 2 0 0 2 2 2 0 LIM domain FYVE_2 PF02318.11 ERZ94835.1 - 5.6 6.8 8.0 2 8.3 0.6 2.2 1 1 1 2 2 2 0 FYVE-type zinc finger Cytochrome_C7 PF14522.1 ERZ94835.1 - 6 6.5 8.1 12 5.6 0.8 2.2 1 1 0 2 2 2 0 Cytochrome c7 Prim_Zn_Ribbon PF08273.7 ERZ94835.1 - 6.9 6.8 8.6 7.2 6.7 0.3 2.7 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase DUF4428 PF14471.1 ERZ94835.1 - 8.1 6.2 0.0 8.1 6.2 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4428) TF_Zn_Ribbon PF08271.7 ERZ94835.1 - 8.3 5.8 12.1 7.7 5.9 1.4 3.2 2 2 1 3 3 3 0 TFIIB zinc-binding zf-UDP PF14569.1 ERZ94835.1 - 8.4 6.2 9.3 0.92 9.2 1.1 2.4 1 1 0 2 2 2 0 Zinc-binding RING-finger 3Beta_HSD PF01073.14 ERZ94836.1 - 1.1e-71 240.7 0.0 1.3e-71 240.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ERZ94836.1 - 1e-38 133.1 0.0 1.3e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ERZ94836.1 - 7e-19 67.7 0.0 3.6e-17 62.1 0.0 2.0 1 1 1 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 ERZ94836.1 - 8.9e-16 57.6 0.0 1.2e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 ERZ94836.1 - 1.9e-14 54.1 0.0 2.8e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 ERZ94836.1 - 1.1e-07 31.1 0.1 7.6e-07 28.3 0.1 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.5 ERZ94836.1 - 0.0016 18.1 0.1 0.078 12.6 0.1 2.6 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 ERZ94836.1 - 0.004 17.0 0.0 0.03 14.2 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 ERZ94836.1 - 0.043 13.0 0.0 0.12 11.5 0.0 1.7 1 1 0 1 1 1 0 NmrA-like family Sec5 PF15469.1 ERZ94837.1 - 0.029 14.0 1.0 0.078 12.7 0.2 1.9 1 1 1 2 2 2 0 Exocyst complex component Sec5 Ecl1 PF12855.2 ERZ94837.1 - 0.03 13.6 2.7 0.078 12.2 1.9 1.7 1 1 0 1 1 1 0 Life-span regulatory factor DUF3399 PF11879.3 ERZ94837.1 - 0.068 13.4 0.3 0.12 12.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) DUF1849 PF08904.6 ERZ94838.1 - 0.012 15.0 4.7 0.013 14.8 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1849) FERM_M PF00373.13 ERZ94838.1 - 0.015 15.4 0.4 0.02 15.0 0.3 1.2 1 0 0 1 1 1 0 FERM central domain DUF4613 PF15390.1 ERZ94838.1 - 4.2 5.4 6.6 4.5 5.3 4.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Avl9 PF09794.4 ERZ94840.1 - 0.097 11.1 0.7 0.076 11.4 0.5 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Sigma_reg_N PF13800.1 ERZ94840.1 - 1.4 8.9 4.9 1.9 8.5 3.4 1.1 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF316 PF03761.10 ERZ94841.1 - 0.0043 16.4 0.1 0.0068 15.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF316) DUF4218 PF13960.1 ERZ94841.1 - 0.074 12.4 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) Ecl1 PF12855.2 ERZ94842.1 - 0.0045 16.2 1.0 0.0097 15.1 0.7 1.6 1 0 0 1 1 1 1 Life-span regulatory factor DUF3279 PF11682.3 ERZ94842.1 - 0.027 14.0 0.1 0.045 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) Imm27 PF15573.1 ERZ94842.1 - 0.041 13.0 0.2 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Immunity protein 27 Sec5 PF15469.1 ERZ94842.1 - 0.084 12.5 0.6 0.21 11.2 0.1 1.8 1 1 1 2 2 2 0 Exocyst complex component Sec5 DUF3287 PF11690.3 ERZ94843.1 - 0.0022 18.0 0.8 0.004 17.2 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3287) Lge1 PF11488.3 ERZ94843.1 - 0.013 15.6 2.5 0.019 15.1 1.7 1.5 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DivIVA PF05103.8 ERZ94843.1 - 0.018 15.0 1.9 0.028 14.4 1.3 1.2 1 0 0 1 1 1 0 DivIVA protein DUF4189 PF13827.1 ERZ94844.1 - 0.016 15.4 0.8 0.042 14.0 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4189) Rcd1 PF04078.8 ERZ94846.1 - 8.4e-133 441.1 1.5 9.9e-133 440.8 1.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Adeno_E3_CR2 PF02439.10 ERZ94849.1 - 6.1e-05 22.4 2.4 0.0001 21.7 1.7 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 IncA PF04156.9 ERZ94849.1 - 0.0015 18.1 1.2 0.0021 17.6 0.8 1.1 1 0 0 1 1 1 1 IncA protein Shisa PF13908.1 ERZ94849.1 - 0.0015 18.6 0.8 0.0026 17.9 0.6 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Herpes_gE PF02480.11 ERZ94849.1 - 0.034 12.4 0.0 0.038 12.2 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PsbJ PF01788.12 ERZ94849.1 - 0.22 11.0 2.7 0.37 10.3 1.8 1.3 1 0 0 1 1 1 0 PsbJ Mid2 PF04478.7 ERZ94849.1 - 0.77 9.1 6.4 2.8 7.3 4.4 1.9 1 1 0 1 1 1 0 Mid2 like cell wall stress sensor ABC2_membrane_3 PF12698.2 ERZ94849.1 - 7.5 5.4 8.7 0.15 11.0 0.2 1.9 1 1 1 2 2 2 0 ABC-2 family transporter protein Phage_Mu_Gam PF07352.7 ERZ94852.1 - 0.12 11.9 0.1 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Sel1 PF08238.7 ERZ94853.1 - 5.3e-47 157.2 18.8 6.2e-11 42.5 0.5 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ERZ94853.1 - 0.00062 19.5 22.6 0.017 14.9 2.0 5.7 3 2 2 5 5 5 3 MIT (microtubule interacting and transport) domain DUF1979 PF09322.5 ERZ94853.1 - 0.086 12.4 0.0 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) NSF PF02071.15 ERZ94853.1 - 0.26 11.9 10.2 1.1e+02 4.0 0.1 6.3 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_6 PF13174.1 ERZ94853.1 - 6.1 7.5 16.3 3.6 8.2 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat p450 PF00067.17 ERZ94854.1 - 4.2e-16 58.5 0.1 5.2e-16 58.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_C54 PF03416.14 ERZ94855.1 - 8.5e-65 218.6 0.0 1.1e-64 218.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 zf-RVT PF13966.1 ERZ94856.1 - 0.00028 21.1 0.1 0.00028 21.1 0.1 2.6 3 0 0 3 3 3 1 zinc-binding in reverse transcriptase DUF4254 PF14063.1 ERZ94857.1 - 0.011 15.3 0.1 1.1 8.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4254) Toxin_51 PF15531.1 ERZ94857.1 - 0.015 15.0 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Putative toxin 51 RRF_GI PF12614.3 ERZ94857.1 - 0.3 10.8 1.8 1.2 8.8 1.2 2.1 1 1 0 1 1 1 0 Ribosome recycling factor FAD_binding_3 PF01494.14 ERZ94859.1 - 3.2e-10 39.5 0.0 3.7e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain 7TM-7TMR_HD PF07698.6 ERZ94862.1 - 0.037 13.4 0.3 0.044 13.2 0.2 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase ARPC4 PF05856.7 ERZ94862.1 - 0.12 11.7 0.5 0.14 11.5 0.3 1.1 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) Inhibitor_I71 PF12628.2 ERZ94863.1 - 0.12 11.9 0.2 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Retrotrans_gag PF03732.12 ERZ94864.1 - 0.094 12.7 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Retrotransposon gag protein Herpes_ori_bp PF02399.10 ERZ94866.1 - 8.1e-21 73.7 0.1 4.3e-18 64.7 0.0 2.2 2 0 0 2 2 2 2 Origin of replication binding protein AAA_11 PF13086.1 ERZ94866.1 - 0.024 14.2 0.0 0.074 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain Transposase_28 PF04195.7 ERZ94866.1 - 0.071 12.3 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative gypsy type transposon AAA PF00004.24 ERZ94866.1 - 0.11 12.7 0.0 0.91 9.7 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NPBW PF15180.1 ERZ94867.1 - 0.029 14.0 0.2 0.058 13.0 0.2 1.4 1 0 0 1 1 1 0 Neuropeptides B and W Saccharop_dh PF03435.13 ERZ94869.1 - 3.4e-93 312.6 0.0 5.7e-93 311.9 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase AlaDh_PNT_N PF05222.10 ERZ94869.1 - 1.5e-27 96.2 0.0 3.2e-27 95.1 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 ERZ94869.1 - 6.3e-26 90.9 0.0 2e-25 89.2 0.0 1.9 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.1 ERZ94869.1 - 0.00013 21.9 0.0 0.00036 20.6 0.0 1.8 1 0 0 1 1 1 1 NADH(P)-binding Shikimate_DH PF01488.15 ERZ94869.1 - 0.00022 21.3 0.3 0.0038 17.3 0.1 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.15 ERZ94869.1 - 0.0058 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 ERZ94869.1 - 0.017 13.8 0.0 0.033 12.8 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.19 ERZ94869.1 - 0.053 13.8 0.1 0.43 10.9 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.10 ERZ94869.1 - 0.07 11.8 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Aph-1 PF06105.7 ERZ94870.1 - 1.4e-58 197.9 15.3 1.6e-58 197.7 10.6 1.0 1 0 0 1 1 1 1 Aph-1 protein BTB PF00651.26 ERZ94874.1 - 2.1e-16 59.8 0.1 4.7e-16 58.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ94874.1 - 2.7e-06 27.1 1.6 1.7e-05 24.6 0.0 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ94874.1 - 1.6e-05 24.8 1.9 4e-05 23.6 1.3 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ERZ94875.1 - 2.9e-17 62.6 0.6 2e-16 59.9 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ94875.1 - 3.5e-10 39.6 4.7 3.5e-09 36.4 0.2 3.5 3 1 1 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ94875.1 - 8.5e-07 29.0 4.6 1.8e-06 28.0 1.8 2.5 2 0 0 2 2 2 1 TLD DUF3342 PF11822.3 ERZ94875.1 - 0.02 14.0 1.2 0.031 13.4 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) TLD PF07534.11 ERZ94876.1 - 6.4e-07 29.4 4.7 1.9e-06 27.9 3.3 1.8 1 0 0 1 1 1 1 TLD BTB PF00651.26 ERZ94876.1 - 1.5e-06 28.1 0.8 3.1e-06 27.1 0.5 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ94876.1 - 4.5e-05 23.2 6.4 0.0019 18.0 0.3 3.3 2 1 1 3 3 3 1 BTB And C-terminal Kelch Sel1 PF08238.7 ERZ94877.1 - 8.2e-41 137.5 9.2 1.7e-09 38.0 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ERZ94877.1 - 0.0005 19.9 6.1 4 7.3 0.1 4.4 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain MTBP_C PF14920.1 ERZ94877.1 - 0.011 15.2 0.2 0.059 12.8 0.0 2.1 2 0 0 2 2 2 0 MDM2-binding AdoMet_MTase PF07757.8 ERZ94877.1 - 0.018 15.1 0.1 22 5.2 0.0 3.3 3 0 0 3 3 3 0 Predicted AdoMet-dependent methyltransferase DUF3872 PF12988.2 ERZ94878.1 - 0.05 13.1 0.4 0.067 12.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Rotamase_3 PF13616.1 ERZ94878.1 - 0.07 13.4 0.4 0.21 11.8 0.1 1.8 1 1 1 2 2 2 0 PPIC-type PPIASE domain Ribonuc_red_lgN PF00317.16 ERZ94878.1 - 5.8 6.7 5.8 18 5.2 4.0 1.8 1 1 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain HTH_Tnp_Tc5 PF03221.11 ERZ94883.1 - 0.00067 19.4 0.2 0.0015 18.2 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ94883.1 - 0.02 14.0 0.0 0.035 13.2 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease Pkinase_Tyr PF07714.12 ERZ94884.1 - 1.9e-32 112.3 0.0 2.3e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94884.1 - 6e-32 110.8 0.0 7.7e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ94884.1 - 0.013 15.1 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TLD PF07534.11 ERZ94885.1 - 6.6e-16 58.5 1.4 1.3e-15 57.5 1.0 1.5 1 0 0 1 1 1 1 TLD FRG PF08867.6 ERZ94885.1 - 0.036 14.5 0.1 0.088 13.3 0.1 1.6 1 0 0 1 1 1 0 FRG domain BTB PF00651.26 ERZ94886.1 - 3.3e-19 68.9 0.1 6.3e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ94886.1 - 2e-15 56.9 0.1 8.8e-15 54.9 0.0 2.2 1 0 0 1 1 1 1 TLD Med27 PF11571.3 ERZ94887.1 - 0.17 12.0 3.5 0.17 12.0 0.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 27 DUF4435 PF14491.1 ERZ94888.1 - 0.08 12.7 1.4 0.096 12.4 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4435) E1-E2_ATPase PF00122.15 ERZ94889.1 - 5.3e-57 192.5 1.8 5.3e-57 192.5 1.3 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ERZ94889.1 - 1.2e-44 151.9 12.8 1.2e-44 151.9 8.8 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ERZ94889.1 - 9.4e-25 88.2 0.2 3.8e-24 86.2 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ERZ94889.1 - 9.8e-20 70.3 0.0 2.2e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ERZ94889.1 - 8.1e-14 52.2 0.1 5.3e-13 49.5 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ERZ94889.1 - 1.3e-09 37.3 0.2 1.8e-07 30.5 0.0 2.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ERZ94889.1 - 0.0002 21.0 5.8 0.00072 19.2 0.1 3.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HMGL-like PF00682.14 ERZ94890.1 - 9.9e-78 261.0 0.0 2.5e-77 259.7 0.0 1.7 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 ERZ94890.1 - 6e-29 100.5 1.1 1.2e-28 99.4 0.7 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain adh_short PF00106.20 ERZ94891.1 - 1.7e-24 86.6 0.0 2.7e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ERZ94891.1 - 1.6e-09 37.8 0.0 2.3e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ERZ94891.1 - 6.6e-08 32.4 0.6 6.4e-07 29.2 0.4 2.0 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 ERZ94891.1 - 1.6e-05 25.0 0.0 3.1e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ERZ94891.1 - 0.0013 18.2 0.2 0.0028 17.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ERZ94891.1 - 0.013 14.4 0.0 0.018 13.9 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Urocanase PF01175.13 ERZ94891.1 - 0.016 13.3 0.0 0.021 12.9 0.0 1.1 1 0 0 1 1 1 0 Urocanase 3Beta_HSD PF01073.14 ERZ94891.1 - 0.026 13.2 0.2 0.037 12.7 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family UDPG_MGDP_dh_N PF03721.9 ERZ94891.1 - 0.12 11.7 0.2 0.23 10.8 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ribosomal_L29 PF00831.18 ERZ94892.1 - 8.2e-19 67.0 2.6 8.2e-19 67.0 1.8 2.0 2 0 0 2 2 2 1 Ribosomal L29 protein Snapin_Pallidin PF14712.1 ERZ94892.1 - 0.049 13.9 1.6 0.049 13.9 1.1 2.1 1 1 1 2 2 2 0 Snapin/Pallidin CK2S PF15011.1 ERZ94892.1 - 0.058 13.1 1.3 0.11 12.3 0.9 1.5 1 1 0 1 1 1 0 Casein Kinase 2 substrate FlxA PF14282.1 ERZ94892.1 - 0.092 12.7 4.2 0.15 12.0 2.9 1.3 1 0 0 1 1 1 0 FlxA-like protein FliJ PF02050.11 ERZ94892.1 - 0.37 10.8 6.7 0.33 11.0 4.2 1.4 1 1 0 1 1 1 0 Flagellar FliJ protein HR1 PF02185.11 ERZ94892.1 - 1.1 9.0 7.1 0.57 9.9 0.7 2.6 1 1 1 2 2 2 0 Hr1 repeat DUF603 PF04645.7 ERZ94892.1 - 7.8 6.3 7.5 4.1 7.3 0.8 2.2 1 1 0 2 2 2 0 Protein of unknown function, DUF603 Acyl-CoA_dh_1 PF00441.19 ERZ94893.1 - 6.8e-46 156.0 0.9 1e-45 155.5 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ERZ94893.1 - 1.6e-24 86.6 0.0 4.1e-24 85.3 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ERZ94893.1 - 3.3e-20 71.3 0.0 1.2e-19 69.5 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ERZ94893.1 - 1.2e-17 64.3 0.0 1.7e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 ERZ94893.1 - 0.098 12.0 1.1 0.33 10.2 0.1 2.3 2 1 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal FlhD PF05247.8 ERZ94897.1 - 0.11 12.4 0.3 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 Flagellar transcriptional activator (FlhD) zf-RING_2 PF13639.1 ERZ94902.1 - 1.1e-15 57.1 5.2 1.8e-15 56.4 3.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ERZ94902.1 - 3.7e-09 36.5 2.4 8.4e-09 35.4 1.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ERZ94902.1 - 1e-07 31.4 4.3 2e-07 30.5 3.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ94902.1 - 1.1e-07 31.4 2.8 1.9e-07 30.6 2.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ERZ94902.1 - 1.6e-07 31.1 5.3 2.9e-07 30.3 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ94902.1 - 0.0001 21.9 4.4 0.00019 21.0 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ERZ94902.1 - 0.0012 18.6 1.7 0.0033 17.2 1.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1049 PF06305.6 ERZ94902.1 - 0.0033 16.8 0.1 0.0071 15.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1049) PHD PF00628.24 ERZ94902.1 - 0.0047 16.5 4.0 0.0087 15.7 2.8 1.4 1 0 0 1 1 1 1 PHD-finger RINGv PF12906.2 ERZ94902.1 - 0.033 14.2 5.9 0.069 13.1 4.1 1.6 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 ERZ94902.1 - 0.56 9.8 7.2 1.1 8.9 5.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF221 PF02714.10 ERZ94903.1 - 6.6e-87 291.4 27.5 1e-86 290.7 19.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ERZ94903.1 - 7.3e-33 113.3 1.2 7.3e-33 113.3 0.8 2.5 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ERZ94903.1 - 0.053 14.0 0.4 0.64 10.5 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4463) RrnaAD PF00398.15 ERZ94904.1 - 0.084 11.8 0.0 0.088 11.8 0.0 1.0 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TLD PF07534.11 ERZ94905.1 - 4.4e-14 52.6 0.4 5.3e-14 52.3 0.3 1.1 1 0 0 1 1 1 1 TLD ZZ PF00569.12 ERZ94905.1 - 0.0053 16.2 2.3 0.0053 16.2 1.6 1.8 2 0 0 2 2 2 1 Zinc finger, ZZ type Pox_A32 PF04665.7 ERZ94908.1 - 0.0038 16.5 0.1 0.0043 16.3 0.0 1.2 1 1 0 1 1 1 1 Poxvirus A32 protein Zot PF05707.7 ERZ94908.1 - 0.0039 16.6 0.0 0.0042 16.5 0.0 1.1 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) DUF1664 PF07889.7 ERZ94910.1 - 0.0078 16.0 2.6 0.0096 15.7 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) SLA_LP_auto_ag PF05889.8 ERZ94910.1 - 0.015 13.7 0.5 0.016 13.6 0.3 1.0 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) DUF4559 PF15112.1 ERZ94910.1 - 0.026 13.6 2.1 0.026 13.7 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) OrfB_IS605 PF01385.14 ERZ94910.1 - 0.038 13.3 1.9 0.044 13.1 1.3 1.1 1 0 0 1 1 1 0 Probable transposase Latarcin PF10279.4 ERZ94910.1 - 0.082 13.1 0.8 0.13 12.4 0.6 1.4 1 0 0 1 1 1 0 Latarcin precursor Abp2 PF09441.5 ERZ94911.1 - 1.3e-32 113.0 0.0 3.9e-32 111.5 0.0 1.8 1 0 0 1 1 1 1 ARS binding protein 2 SAGA-Tad1 PF12767.2 ERZ94911.1 - 9.3 5.8 35.2 1.1 8.8 3.9 2.2 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Sp100 PF03172.8 ERZ94913.1 - 0.0037 17.2 0.3 0.03 14.2 0.1 2.6 1 1 1 2 2 2 1 Sp100 domain Pkinase PF00069.20 ERZ94914.1 - 1.3e-28 99.9 1.1 1.5e-28 99.7 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ94914.1 - 1.1e-26 93.4 0.0 1.3e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ94914.1 - 0.00076 18.8 0.3 0.0016 17.8 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ94914.1 - 0.018 14.7 0.1 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ERZ94915.1 - 1.5e-65 216.1 20.8 2.3e-09 37.5 0.0 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ERZ94915.1 - 0.002 18.4 12.3 57 4.4 0.0 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat Papo_T_antigen PF02380.10 ERZ94915.1 - 0.0082 16.0 0.7 3 7.8 0.0 4.1 4 1 0 4 4 4 1 T-antigen specific domain Ten1 PF12658.2 ERZ94918.1 - 0.053 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Telomere capping, CST complex subunit DUF3089 PF11288.3 ERZ94918.1 - 0.098 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Sad1_UNC PF07738.8 ERZ94919.1 - 7.6e-33 113.1 0.0 1e-14 54.5 0.0 3.5 3 0 0 3 3 3 2 Sad1 / UNC-like C-terminal EIIBC-GUT_N PF03612.9 ERZ94919.1 - 0.1 12.2 0.9 0.24 10.9 0.1 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus PIG-P PF08510.7 ERZ94919.1 - 1.2 8.7 8.4 0.13 11.9 1.1 2.7 2 1 1 3 3 3 0 PIG-P TTL PF03133.10 ERZ94920.1 - 9.5e-47 159.3 9.9 1.2e-46 158.9 6.9 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ERZ94920.1 - 0.00059 18.7 0.1 0.11 11.2 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 ERZ94920.1 - 0.00098 18.8 1.1 0.0058 16.3 0.1 2.2 2 0 0 2 2 2 1 ATP-grasp domain SecA_SW PF07516.8 ERZ94920.1 - 0.021 14.5 4.7 0.034 13.9 3.0 1.5 1 1 0 1 1 1 0 SecA Wing and Scaffold domain YtzH PF14165.1 ERZ94921.1 - 0.049 13.8 2.1 2.2 8.5 0.0 3.0 2 1 1 3 3 3 0 YtzH-like protein DrrA_P4M PF14860.1 ERZ94921.1 - 0.33 10.7 6.8 3.2 7.5 0.1 2.5 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain PQQ_2 PF13360.1 ERZ94923.1 - 6.8e-18 64.9 0.2 1.3e-12 47.7 0.1 1.9 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.16 ERZ94923.1 - 8.6e-14 50.2 0.6 0.0068 15.8 0.0 4.3 4 0 0 4 4 4 4 PQQ enzyme repeat PQQ_3 PF13570.1 ERZ94923.1 - 3.2e-10 39.9 0.7 6.9e-05 22.9 0.1 5.3 5 1 0 5 5 5 2 PQQ-like domain Med28 PF11594.3 ERZ94926.1 - 0.0048 17.1 1.6 0.0077 16.4 1.1 1.4 1 1 0 1 1 1 1 Mediator complex subunit 28 UBN_AB PF14075.1 ERZ94926.1 - 0.036 13.7 1.3 0.046 13.4 0.9 1.0 1 0 0 1 1 1 0 Ubinuclein conserved middle domain TRP PF06011.7 ERZ94927.1 - 0.06 11.9 0.0 0.068 11.7 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Yos1 PF08571.5 ERZ94927.1 - 0.072 13.1 0.1 0.093 12.8 0.1 1.2 1 0 0 1 1 1 0 Yos1-like DUF2807 PF10988.3 ERZ94928.1 - 0.13 11.7 4.8 0.35 10.3 3.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2807) MMtag PF10159.4 ERZ94929.1 - 0.29 11.2 3.7 1.2 9.2 2.6 2.1 1 0 0 1 1 1 0 Kinase phosphorylation protein RINT1_TIP1 PF04437.8 ERZ94931.1 - 0.014 13.9 0.1 0.034 12.7 0.1 1.7 1 1 1 2 2 2 0 RINT-1 / TIP-1 family FAD_binding_6 PF00970.19 ERZ94933.1 - 1.6e-12 47.3 0.0 3.7e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 ERZ94933.1 - 9.7e-10 38.1 0.0 1.7e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 ERZ94933.1 - 2.9e-09 37.4 0.0 1.2e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cytochrom_B561 PF03188.11 ERZ94933.1 - 1.9e-05 24.4 5.6 3.3e-05 23.7 3.9 1.3 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 NAD_binding_6 PF08030.7 ERZ94933.1 - 4.3e-05 23.4 0.0 0.022 14.6 0.0 2.9 3 0 0 3 3 3 2 Ferric reductase NAD binding domain BLOC1_2 PF10046.4 ERZ94934.1 - 0.033 14.3 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pkinase_Tyr PF07714.12 ERZ94935.1 - 2.9e-38 131.4 0.0 5.1e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94935.1 - 8.8e-33 113.5 0.0 1.5e-32 112.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ94935.1 - 0.0006 19.6 0.0 0.00098 18.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ94935.1 - 0.00062 18.8 0.0 0.00095 18.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ERZ94935.1 - 0.0031 17.1 0.0 0.28 10.7 0.0 2.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.17 ERZ94935.1 - 0.039 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.12 ERZ94936.1 - 1.3e-46 158.8 0.0 1.9e-46 158.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ94936.1 - 5.6e-38 130.5 0.4 1.2e-37 129.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ERZ94936.1 - 0.013 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ94936.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ERZ94938.1 - 0.025 14.2 0.2 0.063 13.0 0.2 1.7 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.2 ERZ94939.1 - 0.0061 16.2 0.3 0.033 13.9 0.2 2.3 2 0 0 2 2 2 1 F-box-like Cut8_C PF08559.5 ERZ94940.1 - 0.013 15.3 0.2 0.03 14.1 0.1 1.5 1 0 0 1 1 1 0 Cut8 six-helix bundle PUB PF09409.5 ERZ94942.1 - 0.0096 15.6 2.2 2.9 7.7 0.1 3.2 1 1 1 2 2 2 2 PUB domain Transposase_28 PF04195.7 ERZ94942.1 - 0.1 11.8 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative gypsy type transposon Herpes_ori_bp PF02399.10 ERZ94943.1 - 9.1e-17 60.3 0.5 5.1e-14 51.2 0.1 2.0 2 0 0 2 2 2 2 Origin of replication binding protein AAA_11 PF13086.1 ERZ94943.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain SAP18 PF06487.7 ERZ94944.1 - 0.079 12.7 0.1 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) PBP1_TM PF14812.1 ERZ94944.1 - 0.93 9.8 5.5 1.6 9.1 3.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 ERZ94944.1 - 1.9 7.9 5.8 3 7.3 4.0 1.3 1 0 0 1 1 1 0 Nucleoplasmin DUF2457 PF10446.4 ERZ94944.1 - 3.6 6.1 7.5 4.3 5.9 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 ERZ94944.1 - 3.7 6.7 6.4 4.9 6.3 4.4 1.1 1 0 0 1 1 1 0 NOA36 protein Sel1 PF08238.7 ERZ94945.1 - 1.8e-33 114.2 11.8 5.7e-12 45.8 0.5 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ERZ94945.1 - 0.00095 19.4 9.0 1.1 9.9 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ94945.1 - 0.0083 15.7 10.6 0.43 10.2 0.5 3.0 1 1 2 3 3 3 3 TPR repeat TPR_16 PF13432.1 ERZ94945.1 - 0.025 15.2 0.2 1.9 9.2 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.15 ERZ94945.1 - 0.04 14.4 2.7 21 6.3 0.0 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_12 PF13424.1 ERZ94945.1 - 0.23 11.3 9.1 0.65 9.9 1.0 3.8 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ94945.1 - 1.6 8.8 14.3 4.9 7.3 0.1 5.7 6 1 1 7 7 7 0 Tetratricopeptide repeat MIT PF04212.13 ERZ94945.1 - 1.8 8.5 8.6 13 5.7 1.3 3.8 2 2 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF424 PF04242.8 ERZ94946.1 - 0.034 14.1 0.6 0.054 13.5 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF424) Sel1 PF08238.7 ERZ94947.1 - 8.3e-96 312.3 27.6 7.2e-10 39.1 0.2 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ERZ94947.1 - 8e-07 29.1 18.5 0.88 10.1 0.0 8.0 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ94947.1 - 0.00016 21.2 35.0 0.1 12.2 0.2 8.1 2 2 6 8 8 8 4 TPR repeat MIT PF04212.13 ERZ94947.1 - 0.0022 17.8 24.1 1.6 8.6 3.4 7.2 4 3 3 7 7 7 4 MIT (microtubule interacting and transport) domain NSF PF02071.15 ERZ94947.1 - 0.17 12.4 13.1 16 6.6 0.1 6.9 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat TPR_20 PF14561.1 ERZ94947.1 - 3 8.0 5.5 25 5.0 0.6 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Osmo_CC PF08946.5 ERZ94951.1 - 0.076 13.0 1.1 0.095 12.7 0.8 1.2 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Herpes_ori_bp PF02399.10 ERZ94953.1 - 1.4e-12 46.4 0.3 1.8e-12 46.0 0.2 1.0 1 0 0 1 1 1 1 Origin of replication binding protein Methyltransf_4 PF02390.12 ERZ94955.1 - 2.8e-08 33.0 0.1 1.3e-07 30.8 0.0 1.9 1 1 1 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.1 ERZ94955.1 - 1.3e-07 31.3 1.1 9.8e-05 21.9 0.0 2.7 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ94955.1 - 2.9e-07 30.3 0.0 3.8e-05 23.4 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ94955.1 - 4.8e-06 26.9 0.0 0.027 14.9 0.0 2.7 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ94955.1 - 4.9e-06 27.1 0.0 1.4e-05 25.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ERZ94955.1 - 8.3e-05 22.3 0.8 0.021 14.4 0.2 2.2 1 1 1 2 2 2 2 Hypothetical methyltransferase Methyltransf_25 PF13649.1 ERZ94955.1 - 0.0002 21.6 0.0 0.0016 18.8 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ94955.1 - 0.0011 18.1 0.2 1.3 8.0 0.0 2.6 2 1 1 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.6 ERZ94955.1 - 0.0012 17.6 0.0 0.002 16.8 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_12 PF08242.7 ERZ94955.1 - 0.0017 18.8 0.0 0.013 15.9 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ERZ94955.1 - 0.017 15.1 0.1 0.033 14.1 0.1 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.9 ERZ94955.1 - 0.048 13.0 0.0 0.1 11.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Med2 PF11214.3 ERZ94955.1 - 0.092 12.7 0.6 0.57 10.2 0.0 2.2 2 1 0 2 2 2 0 Mediator complex subunit 2 Rifin_STEVOR PF02009.11 ERZ94956.1 - 0.00017 21.3 0.4 0.0002 21.1 0.3 1.1 1 0 0 1 1 1 1 Rifin/stevor family DUF3433 PF11915.3 ERZ94956.1 - 0.035 14.2 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3433) DUF3290 PF11694.3 ERZ94956.1 - 0.049 13.3 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) HAMP PF00672.20 ERZ94956.1 - 0.16 12.1 0.4 0.32 11.2 0.3 1.5 1 0 0 1 1 1 0 HAMP domain SKG6 PF08693.5 ERZ94956.1 - 1.6 8.0 5.4 3.2 7.1 3.7 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PSII_Ycf12 PF05969.6 ERZ94956.1 - 6.5 6.4 6.8 18 5.0 4.7 1.8 1 1 0 1 1 1 0 Photosystem II complex subunit Ycf12 Kelch_2 PF07646.10 ERZ94957.1 - 2.5e-12 46.0 3.4 0.016 14.9 0.0 5.6 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ERZ94957.1 - 3e-09 36.7 8.8 0.0058 16.7 0.0 6.0 6 2 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ94957.1 - 1.8e-08 34.1 12.9 0.0049 16.9 0.0 5.8 6 1 1 7 7 7 3 Kelch motif Kelch_4 PF13418.1 ERZ94957.1 - 3e-08 33.2 11.3 0.0031 17.2 0.1 6.3 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ERZ94957.1 - 6.2e-08 32.0 6.9 0.0076 15.7 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 ERZ94957.1 - 5.8e-06 26.1 8.9 0.036 14.0 0.0 5.4 6 0 0 6 6 6 2 Kelch motif DUF605 PF04652.11 ERZ94958.1 - 0.027 13.8 6.2 0.03 13.7 4.3 1.1 1 0 0 1 1 1 0 Vta1 like YwpF PF14183.1 ERZ94961.1 - 0.022 14.4 7.0 0.048 13.3 4.7 1.7 1 1 0 1 1 1 0 YwpF-like protein Esterase PF00756.15 ERZ94963.1 - 0.00073 19.0 0.2 0.0011 18.3 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Myb_DNA-bind_4 PF13837.1 ERZ94963.1 - 0.041 14.0 6.2 0.11 12.6 0.6 2.8 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Nnf1 PF03980.9 ERZ94963.1 - 0.16 12.0 5.9 0.039 13.9 1.9 1.6 2 0 0 2 2 2 0 Nnf1 DUF445 PF04286.7 ERZ94963.1 - 0.25 10.8 3.3 0.29 10.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) zf-Dof PF02701.10 ERZ94966.1 - 0.026 14.4 1.8 0.066 13.1 1.2 1.6 1 0 0 1 1 1 0 Dof domain, zinc finger p450 PF00067.17 ERZ94967.1 - 1.8e-42 145.4 0.0 2e-42 145.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2_4 PF13894.1 ERZ94968.1 - 0.0012 19.0 3.0 0.0025 18.0 2.1 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ERZ94968.1 - 0.002 18.3 4.3 0.002 18.3 3.0 1.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ERZ94968.1 - 0.46 10.8 2.5 2 8.8 0.1 2.3 2 1 0 2 2 2 0 Zinc-finger double domain Mrr_cat PF04471.7 ERZ94971.1 - 2.8e-06 27.1 0.6 0.00024 20.8 0.0 2.2 2 0 0 2 2 2 2 Restriction endonuclease DUF2034 PF10356.4 ERZ94971.1 - 0.028 13.6 3.2 0.023 13.8 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2034) NOB1_Zn_bind PF08772.6 ERZ94973.1 - 4 7.3 20.6 0.49 10.2 0.4 4.5 4 0 0 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like Cript PF10235.4 ERZ94973.1 - 4.4 7.7 27.2 3.7 7.9 0.6 4.5 4 0 0 4 4 4 0 Microtubule-associated protein CRIPT DnaJ_CXXCXGXG PF00684.14 ERZ94973.1 - 9.8 6.3 21.3 2.6 8.1 0.2 4.1 4 0 0 4 4 4 0 DnaJ central domain TLD PF07534.11 ERZ94975.1 - 5.1e-10 39.4 1.4 5.9e-10 39.2 0.9 1.0 1 0 0 1 1 1 1 TLD PaRep2a PF07903.6 ERZ94976.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 PaRep2a protein Lung_7-TM_R PF06814.8 ERZ94978.1 - 1e-05 24.6 0.0 1.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Lung seven transmembrane receptor HlyD_2 PF12700.2 ERZ94978.1 - 0.11 11.6 0.2 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF2745 PF10922.3 ERZ94979.1 - 0.099 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) Las1 PF04031.8 ERZ94980.1 - 1.9e-50 170.5 0.2 3.6e-50 169.6 0.2 1.5 1 0 0 1 1 1 1 Las1-like LRR_4 PF12799.2 ERZ94981.1 - 4.1e-05 23.1 9.9 7.2 6.3 0.1 6.2 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) PDCD2_C PF04194.8 ERZ94982.1 - 1.5e-35 122.2 1.1 1.5e-35 122.2 0.7 4.0 3 1 2 5 5 5 1 Programmed cell death protein 2, C-terminal putative domain MBOAT PF03062.14 ERZ94983.1 - 4.8e-46 157.3 26.1 4.8e-46 157.3 18.1 1.9 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF3160 PF11369.3 ERZ94986.1 - 0.0091 14.3 0.1 0.0096 14.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3160) IFNGR1 PF07140.6 ERZ94986.1 - 1.5 8.5 4.6 7.7 6.2 0.7 2.1 2 0 0 2 2 2 0 Interferon gamma receptor (IFNGR1) zf-RING_2 PF13639.1 ERZ94987.1 - 0.00056 19.6 0.5 0.00092 19.0 0.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ERZ94987.1 - 0.0075 16.3 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ERZ94987.1 - 0.011 15.7 0.8 0.027 14.5 0.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ERZ94987.1 - 0.022 14.3 1.1 0.06 13.0 0.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ94987.1 - 0.029 14.1 0.5 0.054 13.2 0.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain V_ATPase_I PF01496.14 ERZ94988.1 - 0.29 8.9 2.2 0.27 9.0 0.7 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF848 PF05852.6 ERZ94988.1 - 0.62 9.9 7.2 0.062 13.1 1.2 2.1 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) HSF_DNA-bind PF00447.12 ERZ94990.1 - 3.6e-36 123.4 2.1 3.6e-36 123.4 1.5 2.0 2 1 0 2 2 2 1 HSF-type DNA-binding Snapin_Pallidin PF14712.1 ERZ94990.1 - 0.0042 17.3 3.9 0.26 11.6 2.5 3.0 2 1 0 2 2 2 1 Snapin/Pallidin Response_reg PF00072.19 ERZ94990.1 - 0.0047 16.9 0.2 0.012 15.5 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain DUF1647 PF07801.6 ERZ94990.1 - 0.53 9.7 0.0 0.53 9.7 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1647) cobW PF02492.14 ERZ94991.1 - 1.4e-38 132.1 0.0 1.8e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 ERZ94991.1 - 4.8e-05 22.9 0.0 8.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.9 ERZ94991.1 - 0.0083 15.8 0.2 0.052 13.2 0.0 2.3 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B LysM PF01476.15 ERZ94992.1 - 0.0048 16.7 0.0 0.015 15.2 0.0 1.9 1 0 0 1 1 1 1 LysM domain RasGEF PF00617.14 ERZ94993.1 - 2e-40 138.5 0.1 2.2e-40 138.3 0.1 1.0 1 0 0 1 1 1 1 RasGEF domain Sigma70_ner PF04546.8 ERZ94994.1 - 0.55 9.8 2.5 4.7 6.7 1.3 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region BUD22 PF09073.5 ERZ94994.1 - 0.67 8.9 4.6 1 8.3 3.2 1.3 1 0 0 1 1 1 0 BUD22 AAA PF00004.24 ERZ94997.1 - 5.7e-11 42.7 0.0 3.5e-05 24.0 0.0 3.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ94997.1 - 1.3e-05 24.9 0.0 0.00099 18.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ERZ94997.1 - 0.00018 21.6 0.6 1.4 9.0 0.2 4.6 4 1 0 4 4 4 1 AAA domain Sigma54_activ_2 PF14532.1 ERZ94997.1 - 0.0014 18.7 0.0 1.2 9.2 0.0 3.2 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 ERZ94997.1 - 0.002 18.0 0.0 0.012 15.4 0.0 2.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ERZ94997.1 - 0.0057 16.9 0.0 0.17 12.1 0.0 2.9 3 0 0 3 3 3 1 ABC transporter Miro PF08477.8 ERZ94997.1 - 0.0066 16.9 0.1 0.039 14.4 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein Arch_ATPase PF01637.13 ERZ94997.1 - 0.012 15.3 1.6 0.33 10.6 0.0 3.8 5 0 0 5 5 5 0 Archaeal ATPase NACHT PF05729.7 ERZ94997.1 - 0.017 14.7 0.1 2.1 7.9 0.1 3.5 4 0 0 4 4 4 0 NACHT domain DUF258 PF03193.11 ERZ94997.1 - 0.041 13.0 0.0 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 ERZ94997.1 - 0.051 13.5 0.0 5.5 6.9 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.1 ERZ94997.1 - 0.28 10.7 0.0 16 4.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Metallopep PF12044.3 ERZ94998.1 - 2e-124 415.3 0.0 2.3e-124 415.1 0.0 1.0 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_2 PF13574.1 ERZ94998.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like AIG1 PF04548.11 ERZ94999.1 - 4e-51 173.1 6.2 4.8e-32 110.7 0.0 3.1 2 1 0 3 3 3 2 AIG1 family Hint PF01079.15 ERZ94999.1 - 1.5e-20 73.3 0.0 2.7e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Hint module MMR_HSR1 PF01926.18 ERZ94999.1 - 4.7e-17 61.9 1.5 2e-10 40.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ94999.1 - 8.6e-09 35.4 23.6 4.5e-07 29.8 1.5 4.6 3 2 1 4 4 4 3 Dynamin family FeoB_N PF02421.13 ERZ94999.1 - 6.9e-08 31.9 0.4 3.2e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 ERZ94999.1 - 4.8e-07 29.0 0.1 1.4e-05 24.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ERZ94999.1 - 1.7e-06 28.1 0.1 0.0001 22.4 0.0 2.7 3 0 0 3 3 2 1 AAA domain SRPRB PF09439.5 ERZ94999.1 - 5.7e-05 22.4 8.2 0.00028 20.1 0.0 3.0 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 ERZ94999.1 - 5.7e-05 22.6 0.7 0.017 14.5 0.0 2.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ERZ94999.1 - 0.00024 20.3 1.0 0.0046 16.1 0.0 2.8 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region RNA_helicase PF00910.17 ERZ94999.1 - 0.0014 18.7 0.0 0.0076 16.4 0.0 2.2 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.22 ERZ94999.1 - 0.002 18.4 0.0 0.002 18.4 0.0 2.8 3 0 0 3 3 3 1 ABC transporter AAA_18 PF13238.1 ERZ94999.1 - 0.0052 17.0 0.0 0.0052 17.0 0.0 4.0 3 2 0 3 3 1 1 AAA domain AAA_16 PF13191.1 ERZ94999.1 - 0.0064 16.4 1.5 0.047 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 ERZ94999.1 - 0.016 14.7 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 ERZ94999.1 - 0.019 15.4 1.5 0.18 12.3 0.0 2.6 2 1 0 2 2 2 0 Miro-like protein AAA_33 PF13671.1 ERZ94999.1 - 0.031 14.1 1.0 0.1 12.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ERZ94999.1 - 0.034 14.9 0.0 0.034 14.9 0.0 4.1 3 2 0 3 3 2 0 AAA domain ATP_bind_1 PF03029.12 ERZ94999.1 - 0.091 12.2 0.8 25 4.2 0.0 3.3 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein DUF3215 PF11503.3 ERZ94999.1 - 0.11 12.1 0.1 5 6.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3215) AAA_10 PF12846.2 ERZ94999.1 - 0.2 11.0 7.4 0.019 14.4 1.0 2.3 2 1 0 2 2 2 0 AAA-like domain FtsK_SpoIIIE PF01580.13 ERZ94999.1 - 2.2 7.6 5.9 2.7 7.4 0.0 2.8 2 1 1 3 3 3 0 FtsK/SpoIIIE family DDHD PF02862.12 ERZ94999.1 - 6.3 6.5 13.3 3.9 7.2 2.9 2.4 2 0 0 2 2 2 0 DDHD domain Git3_C PF11970.3 ERZ95000.1 - 0.00042 20.0 0.5 0.0012 18.5 0.3 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.16 ERZ95000.1 - 0.0039 16.3 2.8 0.0066 15.6 1.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2207 PF09972.4 ERZ95001.1 - 0.0055 15.3 0.4 0.0069 15.0 0.3 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Pex24p PF06398.6 ERZ95001.1 - 0.15 10.7 2.5 0.43 9.3 0.2 1.9 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin Fumarate_red_C PF02300.12 ERZ95001.1 - 1.7 8.5 6.7 3.1 7.6 4.6 1.4 1 0 0 1 1 1 0 Fumarate reductase subunit C MarB PF13999.1 ERZ95004.1 - 0.073 12.6 0.4 0.15 11.6 0.3 1.5 1 0 0 1 1 1 0 MarB protein HLH PF00010.21 ERZ95005.1 - 8.2e-19 67.0 2.9 1.8e-18 65.9 2.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAP2 PF01569.16 ERZ95006.1 - 1.3e-26 92.7 1.4 1.3e-26 92.7 1.0 1.7 2 0 0 2 2 2 1 PAP2 superfamily SieB PF14163.1 ERZ95006.1 - 0.17 11.4 0.7 0.32 10.5 0.5 1.4 1 0 0 1 1 1 0 Superinfection exclusion protein B TctB PF07331.6 ERZ95006.1 - 0.53 9.9 9.4 8.4 6.0 6.5 2.3 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Virul_fac_BrkB PF03631.10 ERZ95006.1 - 0.65 9.2 6.0 0.81 8.9 0.4 2.2 2 0 0 2 2 2 0 Virulence factor BrkB DUF1705 PF08019.7 ERZ95006.1 - 6.2 6.3 6.6 7.3 6.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1705) NPCC PF08058.6 ERZ95011.1 - 0.041 13.7 1.5 0.048 13.5 1.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex component DASH_Dad4 PF08650.5 ERZ95011.1 - 1.6 8.7 3.7 0.45 10.4 0.2 1.8 2 1 1 3 3 3 0 DASH complex subunit Dad4 Dimer_Tnp_hAT PF05699.9 ERZ95012.1 - 7.7e-20 70.3 0.2 8.9e-20 70.1 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region F-box-like PF12937.2 ERZ95014.1 - 0.0026 17.4 1.9 0.0055 16.4 0.6 2.0 2 0 0 2 2 2 1 F-box-like BBP1_C PF15272.1 ERZ95014.1 - 0.062 12.8 3.5 0.2 11.1 0.4 2.3 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Troponin PF00992.15 ERZ95015.1 - 0.078 13.0 4.8 0.091 12.8 3.3 1.2 1 0 0 1 1 1 0 Troponin DUF4404 PF14357.1 ERZ95015.1 - 0.31 11.4 2.7 0.43 11.0 1.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Wbp11 PF09429.5 ERZ95015.1 - 0.94 9.5 6.5 1.8 8.5 0.1 2.3 1 1 1 2 2 2 0 WW domain binding protein 11 Alginate_lyase PF05426.7 ERZ95018.1 - 3.3e-68 229.9 0.1 4e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 Alginate lyase Prenyltrans_2 PF13249.1 ERZ95018.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Prenyltransferase-like zf-C2H2 PF00096.21 ERZ95019.1 - 1.4e-07 31.4 10.7 1e-05 25.5 1.3 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ERZ95019.1 - 4.2e-05 23.6 3.4 4.2e-05 23.6 2.4 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.2 ERZ95019.1 - 0.0012 18.9 4.0 0.018 15.2 0.6 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 ERZ95019.1 - 0.0014 18.7 10.3 0.0091 16.2 0.7 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ERZ95019.1 - 0.0016 18.4 0.3 0.0016 18.4 0.2 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C4 PF00105.13 ERZ95019.1 - 0.035 14.3 3.3 0.33 11.2 0.2 2.1 1 1 0 2 2 2 0 Zinc finger, C4 type (two domains) zf-C4pol PF14260.1 ERZ95019.1 - 0.24 11.4 2.4 0.37 10.8 1.6 1.4 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Paired_CXXCH_1 PF09699.5 ERZ95019.1 - 3.8 7.1 8.4 0.64 9.5 1.3 2.2 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-C2H2_2 PF12756.2 ERZ95019.1 - 3.8 7.6 8.2 7.9 6.6 0.9 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) SAC3 PF12209.3 ERZ95020.1 - 0.25 11.4 2.2 5.5 7.2 0.2 2.4 1 1 1 2 2 2 0 Leucine permease transcriptional regulator helical domain Glyoxal_oxid_N PF07250.6 ERZ95023.1 - 3.7e-46 157.1 0.0 7.4e-45 152.9 0.0 2.5 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ERZ95023.1 - 5.4e-16 58.4 0.0 1.1e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_4 PF13418.1 ERZ95023.1 - 9.8e-05 22.0 7.4 0.23 11.2 0.0 4.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ95023.1 - 0.0028 17.7 6.7 0.85 9.8 0.0 5.6 5 1 1 6 6 6 1 Kelch motif Kelch_2 PF07646.10 ERZ95023.1 - 0.0056 16.3 0.4 0.23 11.3 0.0 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 ERZ95023.1 - 5.3 7.3 7.1 61 3.9 0.0 4.8 7 0 0 7 7 7 0 Galactose oxidase, central domain OMPdecase PF00215.19 ERZ95024.1 - 2.9e-49 167.5 0.0 3.3e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family CAT_RBD PF03123.10 ERZ95024.1 - 0.078 12.6 0.1 6.6 6.5 0.0 2.4 2 0 0 2 2 2 0 CAT RNA binding domain Nic96 PF04097.9 ERZ95025.1 - 1.8e-128 429.3 5.4 2.6e-128 428.8 3.7 1.1 1 0 0 1 1 1 1 Nup93/Nic96 XRCC1_N PF01834.11 ERZ95025.1 - 0.08 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 XRCC1 N terminal domain Gal4_dimer PF03902.8 ERZ95025.1 - 0.088 12.7 0.2 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 Gal4-like dimerisation domain Trehalase PF01204.13 ERZ95026.1 - 5e-176 586.3 0.9 5.9e-176 586.0 0.6 1.0 1 0 0 1 1 1 1 Trehalase DUF1593 PF07632.6 ERZ95026.1 - 0.014 14.6 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) Peptidase_S21 PF00716.12 ERZ95028.1 - 0.00047 19.6 0.1 0.00079 18.8 0.1 1.3 1 0 0 1 1 1 1 Assemblin (Peptidase family S21) MULE PF10551.4 ERZ95030.1 - 3.9e-08 33.3 0.7 2.8e-06 27.3 0.1 2.7 2 1 0 2 2 2 2 MULE transposase domain MAPEG PF01124.13 ERZ95032.1 - 2.3e-21 75.7 1.0 2.6e-21 75.5 0.7 1.0 1 0 0 1 1 1 1 MAPEG family Asparaginase_2 PF01112.13 ERZ95032.1 - 0.11 11.1 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Asparaginase DUF3217 PF11506.3 ERZ95033.1 - 0.13 11.9 0.7 0.18 11.5 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3217) DDE_3 PF13358.1 ERZ95034.1 - 1.2e-20 73.7 0.0 1e-19 70.7 0.0 1.9 1 1 1 2 2 2 1 DDE superfamily endonuclease rve PF00665.21 ERZ95034.1 - 0.0014 18.7 0.0 0.002 18.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain ZipA_C PF04354.8 ERZ95035.1 - 0.018 14.5 0.2 0.04 13.3 0.1 1.6 1 1 0 1 1 1 0 ZipA, C-terminal FtsZ-binding domain DUF4411 PF14367.1 ERZ95035.1 - 0.063 12.9 0.1 0.16 11.6 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4411) A_deaminase_N PF08451.6 ERZ95035.1 - 0.12 12.3 3.0 0.22 11.5 0.2 2.6 2 1 1 3 3 3 0 Adenosine/AMP deaminase N-terminal UQ_con PF00179.21 ERZ95036.1 - 1e-42 144.8 0.0 1.1e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ERZ95036.1 - 0.0018 18.1 0.0 0.0025 17.7 0.0 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 ERZ95036.1 - 0.015 15.0 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Muted PF14942.1 ERZ95037.1 - 0.0086 15.9 0.1 0.0095 15.8 0.1 1.1 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein DUF4414 PF14377.1 ERZ95037.1 - 0.08 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) AF1Q PF15017.1 ERZ95038.1 - 0.22 11.4 4.2 0.26 11.2 2.9 1.2 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator Nucleoplasmin PF03066.10 ERZ95038.1 - 1.1 8.7 5.7 0.99 8.9 4.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin DUF2457 PF10446.4 ERZ95038.1 - 3.7 6.1 9.1 3.5 6.2 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_N PF04218.8 ERZ95043.1 - 0.11 11.9 0.4 0.15 11.4 0.3 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Sel1 PF08238.7 ERZ95044.1 - 1.4e-70 232.1 23.0 1.8e-12 47.4 0.3 8.2 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ERZ95044.1 - 0.0074 16.6 14.8 1.9 9.1 0.5 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ95044.1 - 0.0079 15.9 2.4 10 6.2 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.13 ERZ95044.1 - 0.17 11.7 18.2 13 5.7 0.3 5.6 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ERZ95044.1 - 0.25 11.2 10.2 8.8 6.3 0.1 4.8 3 3 1 4 4 4 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ERZ95044.1 - 0.33 10.6 9.8 16 5.2 0.1 5.3 4 2 2 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation TPR_16 PF13432.1 ERZ95044.1 - 1.9 9.2 5.2 22 5.8 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ95044.1 - 5.6 6.6 25.7 1.6 8.4 0.3 5.4 3 3 3 6 6 6 0 TPR repeat DDE_1 PF03184.14 ERZ95046.1 - 1.1e-44 152.1 0.2 1.7e-25 89.4 0.0 3.0 2 1 1 3 3 3 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ95046.1 - 9.5e-08 31.7 0.0 2.9e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ERZ95046.1 - 0.013 15.2 0.1 0.033 13.9 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_29 PF13551.1 ERZ95046.1 - 0.016 15.3 0.4 0.053 13.6 0.3 1.9 1 0 0 1 1 1 0 Winged helix-turn helix HTH_32 PF13565.1 ERZ95046.1 - 0.017 15.8 3.7 0.036 14.8 0.4 3.1 4 0 0 4 4 4 0 Homeodomain-like domain HTH_33 PF13592.1 ERZ95046.1 - 0.1 12.1 1.6 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix Pkinase_Tyr PF07714.12 ERZ95050.1 - 1.6e-41 142.1 0.1 5.5e-31 107.5 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95050.1 - 1.7e-36 125.6 0.1 6.3e-30 104.1 0.4 2.2 1 1 1 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ERZ95050.1 - 0.0024 17.2 0.2 0.0047 16.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ95050.1 - 0.023 14.4 0.2 0.091 12.4 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Tetrabrachion PF11401.3 ERZ95050.1 - 0.07 12.9 2.3 2.2e+02 1.7 0.1 5.0 5 0 0 5 5 5 0 Tetrabrachion Pkinase_Tyr PF07714.12 ERZ95051.1 - 8.1e-48 162.7 0.0 1.1e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95051.1 - 1.5e-40 139.0 0.4 1.9e-40 138.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ95051.1 - 0.00053 19.3 1.0 0.00086 18.6 0.6 1.4 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ95051.1 - 0.0016 18.2 0.0 0.015 15.0 0.1 2.3 1 1 2 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ95051.1 - 0.004 16.2 0.1 0.0067 15.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ95051.1 - 0.1 11.8 0.2 0.2 10.9 0.1 1.4 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL TLD PF07534.11 ERZ95052.1 - 5.9e-15 55.4 2.2 7.4e-15 55.1 1.5 1.1 1 0 0 1 1 1 1 TLD TLD PF07534.11 ERZ95054.1 - 1.5e-14 54.1 0.4 2.3e-14 53.5 0.3 1.3 1 0 0 1 1 1 1 TLD Kelch_2 PF07646.10 ERZ95055.1 - 5.3e-12 45.0 1.9 9.2e-05 22.0 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ERZ95055.1 - 6.1e-10 38.9 4.6 0.00024 21.2 0.3 4.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ERZ95055.1 - 8.1e-08 31.9 12.5 0.0037 16.9 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ERZ95055.1 - 1.8e-06 27.3 2.8 0.033 13.7 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 ERZ95055.1 - 6.5e-06 26.1 12.3 1.4 9.1 0.1 5.3 4 1 1 5 5 5 4 Kelch motif Kelch_5 PF13854.1 ERZ95055.1 - 0.00021 21.1 0.0 0.00021 21.1 0.0 4.3 5 0 0 5 5 5 1 Kelch motif CD34_antigen PF06365.7 ERZ95055.1 - 0.067 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family ATG2_CAD PF13329.1 ERZ95057.1 - 9.2e-22 77.2 0.3 1.3e-21 76.8 0.2 1.2 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif CHZ PF09649.5 ERZ95058.1 - 0.12 11.6 2.3 1.2 8.4 0.4 2.7 2 0 0 2 2 2 0 Histone chaperone domain CHZ TFCD_C PF12612.3 ERZ95059.1 - 5.3e-41 140.1 0.2 9.2e-41 139.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal F-box-like PF12937.2 ERZ95061.1 - 8.3e-05 22.2 0.4 0.00012 21.7 0.3 1.2 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ERZ95062.1 - 0.00038 20.1 1.5 0.0018 17.9 1.1 2.1 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ERZ95063.1 - 0.041 13.5 9.4 1 9.0 0.4 3.7 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ95063.1 - 2.9 7.7 13.7 0.75 9.5 1.3 3.3 2 1 1 3 3 3 0 Leucine rich repeat Seadorna_VP7 PF07387.6 ERZ95064.1 - 0.0052 15.6 0.1 0.0065 15.3 0.1 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 EF-hand_2 PF09068.6 ERZ95065.1 - 0.17 11.9 1.7 4 7.5 1.2 2.4 1 1 0 1 1 1 0 EF hand Astacin PF01400.19 ERZ95068.1 - 5.9e-36 123.6 0.4 1.1e-35 122.8 0.2 1.4 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.19 ERZ95068.1 - 0.00047 19.9 0.2 3.3 7.4 0.0 3.1 3 0 0 3 3 3 2 Matrixin Reprolysin_5 PF13688.1 ERZ95068.1 - 0.045 13.6 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DUF4419 PF14388.1 ERZ95070.1 - 1.6e-76 257.3 0.1 2.1e-76 257.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) KH_1 PF00013.24 ERZ95072.1 - 1.2e-06 28.0 3.1 2.6e-06 26.9 2.2 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ95072.1 - 2.9e-06 26.7 2.9 5.6e-06 25.8 2.0 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ERZ95072.1 - 0.036 13.6 1.0 0.1 12.2 0.1 2.2 2 0 0 2 2 2 0 KH domain KH_2 PF07650.12 ERZ95072.1 - 1.3 8.6 6.1 0.41 10.2 1.5 2.2 1 1 1 2 2 2 0 KH domain PARG_cat PF05028.9 ERZ95073.1 - 3.4e-53 181.0 1.1 4.8e-53 180.5 0.7 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF95 PF01944.12 ERZ95074.1 - 0.0089 15.6 6.2 0.012 15.2 4.3 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF95 DUF3311 PF11755.3 ERZ95074.1 - 0.75 9.3 7.1 0.92 9.0 4.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3311) DUF4064 PF13273.1 ERZ95074.1 - 1 9.5 11.2 1.1 9.4 0.6 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) CLU PF13236.1 ERZ95076.1 - 4.9e-81 271.3 0.0 8.9e-81 270.5 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.2 ERZ95076.1 - 2.5e-47 160.9 0.0 6.8e-47 159.5 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 ERZ95076.1 - 4.7e-24 84.3 0.3 1.1e-23 83.1 0.2 1.7 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 ERZ95076.1 - 3e-13 49.4 5.9 0.00015 21.6 0.0 3.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ95076.1 - 5.9e-07 29.2 0.1 0.35 10.8 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat DUF727 PF05303.7 ERZ95076.1 - 0.037 13.8 0.2 0.18 11.5 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF727) TPR_11 PF13414.1 ERZ95076.1 - 0.092 12.4 0.6 9.4 5.9 0.0 2.7 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 ERZ95076.1 - 0.13 12.2 2.6 23 5.1 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DASH_Duo1 PF08651.5 ERZ95079.1 - 0.0013 18.2 0.8 0.005 16.3 0.3 2.0 2 0 0 2 2 2 1 DASH complex subunit Duo1 DUF1024 PF06260.7 ERZ95079.1 - 0.14 12.2 0.3 0.44 10.7 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1024) Hamartin PF04388.7 ERZ95080.1 - 1.4e-09 37.2 21.4 1.9e-05 23.6 8.9 2.4 1 1 1 2 2 2 2 Hamartin protein DUF869 PF05911.6 ERZ95080.1 - 0.019 13.2 23.2 0.028 12.6 16.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF3078 PF11276.3 ERZ95080.1 - 0.026 14.7 7.1 0.15 12.2 2.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3078) HlyD PF00529.15 ERZ95080.1 - 0.065 12.5 5.6 0.37 10.0 2.3 2.5 2 1 1 3 3 3 0 HlyD family secretion protein PTH2 PF01981.11 ERZ95080.1 - 1.1 8.9 6.8 6.9 6.3 2.1 2.6 2 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 PilJ PF13675.1 ERZ95080.1 - 4.3 7.6 8.6 5.1 7.4 0.2 3.3 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term FlaC_arch PF05377.6 ERZ95080.1 - 5.1 7.0 14.0 1.1 9.2 1.4 4.0 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) MT0933_antitox PF14013.1 ERZ95081.1 - 2.5e-06 27.4 16.3 0.017 15.2 3.6 4.3 1 1 3 4 4 4 3 MT0933-like antitoxin protein Cornifin PF02389.10 ERZ95081.1 - 7.5e-05 22.5 1.3 9.4e-05 22.2 0.9 1.2 1 0 0 1 1 1 1 Cornifin (SPRR) family Apolipoprotein PF01442.13 ERZ95081.1 - 0.00066 19.2 23.3 0.0073 15.8 16.0 2.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF1340 PF07067.6 ERZ95081.1 - 0.00099 18.3 4.5 0.15 11.2 0.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1340) KfrA_N PF11740.3 ERZ95081.1 - 0.0079 16.6 16.3 0.023 15.1 4.6 3.3 1 1 2 3 3 3 1 Plasmid replication region DNA-binding N-term bZIP_1 PF00170.16 ERZ95081.1 - 0.0088 15.9 1.4 0.0088 15.9 1.0 3.6 3 1 1 4 4 3 1 bZIP transcription factor DUF1215 PF06744.7 ERZ95081.1 - 0.0091 15.6 1.3 3.8 7.1 0.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1215) RHD3 PF05879.7 ERZ95081.1 - 0.011 13.7 22.6 0.013 13.4 15.7 1.1 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) HALZ PF02183.13 ERZ95081.1 - 0.013 15.1 0.9 0.047 13.4 0.6 1.9 1 0 0 1 1 1 0 Homeobox associated leucine zipper Trigger_C PF05698.9 ERZ95081.1 - 0.025 14.4 6.2 0.025 14.4 4.3 2.8 2 1 1 3 3 3 0 Bacterial trigger factor protein (TF) C-terminus Nup54 PF13874.1 ERZ95081.1 - 0.026 14.2 1.2 0.026 14.2 0.8 2.6 1 1 0 2 2 2 0 Nucleoporin complex subunit 54 DivIC PF04977.10 ERZ95081.1 - 0.054 12.9 0.3 0.054 12.9 0.2 2.8 2 1 1 3 3 3 0 Septum formation initiator YpjP PF14005.1 ERZ95081.1 - 0.069 12.9 23.0 0.67 9.7 6.2 2.5 1 1 1 2 2 2 0 YpjP-like protein DUF445 PF04286.7 ERZ95081.1 - 0.084 12.3 25.3 0.26 10.7 17.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF445) FliG_M PF14841.1 ERZ95081.1 - 0.11 12.5 0.6 0.11 12.5 0.4 4.3 2 1 3 5 5 5 0 FliG middle domain HrcA PF01628.16 ERZ95081.1 - 0.12 11.9 13.5 1.2 8.6 4.2 2.6 1 1 1 2 2 2 0 HrcA protein C terminal domain Fe-ADH_2 PF13685.1 ERZ95081.1 - 0.13 11.5 5.6 19 4.4 3.7 2.4 1 1 0 1 1 1 0 Iron-containing alcohol dehydrogenase RapA_C PF12137.3 ERZ95081.1 - 0.17 10.6 18.2 0.041 12.7 2.5 2.8 1 1 2 3 3 3 0 RNA polymerase recycling family C-terminal CBFD_NFYB_HMF PF00808.18 ERZ95081.1 - 0.25 11.4 19.8 0.77 9.8 0.4 4.8 1 1 3 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Not1 PF04054.10 ERZ95081.1 - 0.38 9.5 5.5 0.49 9.1 3.8 1.2 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 DUF2336 PF10098.4 ERZ95081.1 - 0.46 9.6 5.5 1.6 7.9 3.7 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2336) DUF3510 PF12022.3 ERZ95081.1 - 0.64 10.1 16.8 4.5 7.3 0.9 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF3510) ALO PF04030.9 ERZ95081.1 - 0.76 9.3 3.0 9.9 5.6 0.0 2.1 1 1 1 2 2 2 0 D-arabinono-1,4-lactone oxidase EnY2 PF10163.4 ERZ95081.1 - 0.79 9.6 19.9 21 5.1 0.9 4.4 1 1 2 3 3 3 0 Transcription factor e(y)2 Rsbr_N PF08678.5 ERZ95081.1 - 0.97 9.3 20.1 0.64 9.9 2.8 3.4 1 1 2 3 3 3 0 Rsbr N terminal DUF883 PF05957.8 ERZ95081.1 - 1.5 9.2 17.2 0.073 13.4 1.7 3.5 1 1 1 2 2 1 0 Bacterial protein of unknown function (DUF883) PP2C_2 PF13672.1 ERZ95081.1 - 3.7 6.8 8.4 2.9 7.2 4.4 2.0 1 1 1 2 2 2 0 Protein phosphatase 2C Phage_connect_1 PF05135.8 ERZ95081.1 - 4 7.6 7.2 2.8 8.1 0.9 2.6 1 1 1 2 2 2 0 Phage gp6-like head-tail connector protein DUF4297 PF14130.1 ERZ95081.1 - 4.9 7.0 24.2 0.17 11.8 0.8 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4297) MgtE_N PF03448.12 ERZ95081.1 - 5.4 7.3 14.0 24 5.3 8.8 2.6 1 1 0 1 1 1 0 MgtE intracellular N domain SDH_sah PF01972.11 ERZ95081.1 - 7.1 5.3 8.0 19 3.9 4.4 2.1 1 1 1 2 2 2 0 Serine dehydrogenase proteinase DUF2877 PF11392.3 ERZ95081.1 - 7.3 6.8 6.6 19 5.4 1.3 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2877) DUF2252 PF10009.4 ERZ95081.1 - 8.7 5.1 9.1 5.1 5.8 5.0 1.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) KH_1 PF00013.24 ERZ95084.1 - 5.3e-07 29.1 3.4 6.5e-07 28.9 2.4 1.2 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ95084.1 - 5.9e-06 25.7 2.1 8.9e-06 25.2 1.4 1.4 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ERZ95084.1 - 0.0053 16.3 0.1 0.0072 15.9 0.1 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ERZ95084.1 - 0.031 13.8 0.6 0.032 13.8 0.4 1.3 1 0 0 1 1 1 0 KH domain KH_1 PF00013.24 ERZ95085.1 - 4.2e-08 32.7 1.7 5.1e-08 32.4 1.2 1.1 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ95085.1 - 9.2e-07 28.3 1.5 1.2e-06 28.0 1.1 1.2 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ERZ95085.1 - 0.01 15.4 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 0 KH domain KH_2 PF07650.12 ERZ95085.1 - 0.035 13.6 0.5 0.044 13.3 0.3 1.3 1 0 0 1 1 1 0 KH domain Astacin PF01400.19 ERZ95086.1 - 1.6e-28 99.3 0.3 4.4e-28 97.9 0.2 1.7 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Glyco_transf_8 PF01501.15 ERZ95086.1 - 0.056 12.7 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 Peptidase_M10 PF00413.19 ERZ95086.1 - 0.19 11.4 7.6 0.7 9.6 0.1 2.2 1 1 1 2 2 2 0 Matrixin Lysis_col PF02402.11 ERZ95090.1 - 0.29 10.7 0.1 0.29 10.7 0.1 1.5 2 0 0 2 2 2 0 Lysis protein DUF1679 PF07914.6 ERZ95093.1 - 0.0035 16.0 2.7 0.0035 16.0 1.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) PRK PF00485.13 ERZ95093.1 - 0.048 13.2 1.0 0.1 12.1 0.7 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Pox_polyA_pol_N PF12630.2 ERZ95093.1 - 0.34 11.0 8.4 0.029 14.4 2.4 1.8 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain AAA PF00004.24 ERZ95094.1 - 4e-15 56.1 0.1 1.8e-14 54.0 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95094.1 - 1.2e-05 25.4 0.0 2.9e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 ERZ95094.1 - 0.00026 21.1 1.2 0.00067 19.7 0.0 2.4 3 0 0 3 3 2 1 RNA helicase RuvB_N PF05496.7 ERZ95094.1 - 0.00029 19.9 0.0 0.00053 19.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ERZ95094.1 - 0.0006 19.9 0.0 0.0037 17.3 0.0 2.2 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.8 ERZ95094.1 - 0.00085 18.3 0.0 0.00085 18.3 0.0 1.9 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 ERZ95094.1 - 0.0012 18.6 0.2 0.012 15.3 0.0 2.8 3 2 1 4 4 3 1 AAA domain (dynein-related subfamily) T2SE PF00437.15 ERZ95094.1 - 0.0016 17.3 0.0 0.0035 16.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_17 PF13207.1 ERZ95094.1 - 0.0017 19.2 7.4 0.0027 18.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain Ycf1 PF05758.7 ERZ95094.1 - 0.0021 15.9 13.2 0.0032 15.2 9.2 1.4 1 0 0 1 1 1 1 Ycf1 AAA_19 PF13245.1 ERZ95094.1 - 0.005 16.5 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 ERZ95094.1 - 0.013 15.8 0.0 0.013 15.8 0.0 3.3 3 1 0 3 3 1 0 AAA domain AAA_24 PF13479.1 ERZ95094.1 - 0.013 15.1 0.0 0.013 15.1 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_29 PF13555.1 ERZ95094.1 - 0.016 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 ERZ95094.1 - 0.017 14.3 0.0 0.037 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 ERZ95094.1 - 0.02 14.5 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.18 ERZ95094.1 - 0.021 14.8 0.0 0.021 14.8 0.0 2.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_33 PF13671.1 ERZ95094.1 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ERZ95094.1 - 0.039 13.3 0.0 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.1 ERZ95094.1 - 0.099 12.6 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain Miro PF08477.8 ERZ95094.1 - 0.34 11.4 0.0 0.34 11.4 0.0 2.7 2 1 0 2 2 1 0 Miro-like protein DUF2201_N PF13203.1 ERZ95094.1 - 1.2 8.1 12.2 2.6 7.1 8.5 1.4 1 0 0 1 1 1 0 Putative metallopeptidase domain BCS1_N PF08740.6 ERZ95094.1 - 1.5 8.3 5.6 0.12 12.0 0.2 1.8 2 0 0 2 2 2 0 BCS1 N terminal AAA_11 PF13086.1 ERZ95094.1 - 2.2 7.7 24.1 1.1e+02 2.2 16.4 3.0 1 1 0 1 1 1 0 AAA domain Ammonium_transp PF00909.16 ERZ95095.1 - 1.3e-111 372.8 19.9 1.7e-111 372.5 13.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family SepZ PF06066.6 ERZ95095.1 - 0.032 14.2 0.8 0.1 12.6 0.6 1.9 1 0 0 1 1 1 0 SepZ PGAP1 PF07819.8 ERZ95097.1 - 1.4e-05 24.7 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 ERZ95097.1 - 0.00032 20.0 0.0 0.00045 19.5 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 ERZ95097.1 - 0.00053 19.9 0.0 0.00066 19.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ERZ95097.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ95097.1 - 0.0024 17.4 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.10 ERZ95097.1 - 0.024 13.6 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Pro_isomerase PF00160.16 ERZ95098.1 - 1.2e-46 158.7 0.1 1.4e-46 158.5 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA-synt_2c PF01411.14 ERZ95099.1 - 4.4e-215 715.1 0.0 7.3e-215 714.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 ERZ95099.1 - 9e-19 67.0 1.3 2.2e-18 65.8 0.4 2.2 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 ERZ95099.1 - 3.1e-11 42.8 0.2 7.6e-11 41.5 0.1 1.7 1 0 0 1 1 1 1 DHHA1 domain Fzo_mitofusin PF04799.8 ERZ95099.1 - 0.48 9.7 3.1 2.4 7.5 0.0 2.5 2 0 0 2 2 2 0 fzo-like conserved region PTPA PF03095.10 ERZ95100.1 - 1.1e-115 385.9 0.1 1.3e-115 385.7 0.1 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein FF PF01846.14 ERZ95102.1 - 0.035 14.0 6.2 0.14 12.1 1.5 2.2 1 1 1 2 2 2 0 FF domain BTB PF00651.26 ERZ95103.1 - 0.0091 15.9 0.1 0.02 14.8 0.1 1.7 1 1 0 1 1 1 1 BTB/POZ domain RteC PF09357.5 ERZ95105.1 - 0.38 10.5 4.1 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 RteC protein WD40 PF00400.27 ERZ95108.1 - 4.9e-47 156.1 20.6 3.3e-09 36.2 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ATG16 PF08614.6 ERZ95108.1 - 6e-38 130.6 26.5 8e-38 130.2 18.4 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) eIF2A PF08662.6 ERZ95108.1 - 1.5e-07 31.2 0.1 0.017 14.8 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ERZ95108.1 - 0.00046 18.4 6.7 1.3 7.0 0.0 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Reo_sigmaC PF04582.7 ERZ95108.1 - 0.0052 16.0 1.0 0.0099 15.0 0.7 1.5 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF812 PF05667.6 ERZ95108.1 - 0.0068 14.9 14.2 0.0099 14.4 9.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Cytochrom_D1 PF02239.11 ERZ95108.1 - 0.012 13.9 0.1 0.035 12.4 0.0 1.7 2 0 0 2 2 2 0 Cytochrome D1 heme domain Nbas_N PF15492.1 ERZ95108.1 - 0.017 14.2 0.0 7 5.6 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal GAS PF13851.1 ERZ95108.1 - 0.29 10.3 27.5 0.053 12.7 15.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF972 PF06156.8 ERZ95108.1 - 0.73 10.2 21.4 0.53 10.6 2.6 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 ERZ95108.1 - 0.84 9.7 10.7 2.1 8.4 7.4 1.8 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FliD_C PF07195.7 ERZ95108.1 - 2.4 7.3 13.9 0.2 10.9 0.2 2.7 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Phage_GPO PF05929.6 ERZ95108.1 - 5.8 6.0 14.2 0.68 9.1 6.2 1.9 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ADIP PF11559.3 ERZ95108.1 - 6.6 6.6 29.0 3.6 7.4 6.1 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Syntaxin-6_N PF09177.6 ERZ95108.1 - 9.9 6.6 13.5 5 7.5 3.0 3.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Ras PF00071.17 ERZ95109.1 - 2.2e-58 196.2 0.2 2.6e-58 195.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ95109.1 - 6.5e-20 71.8 0.1 1.3e-19 70.8 0.0 1.5 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 ERZ95109.1 - 5.3e-15 55.0 0.1 6.1e-15 54.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ERZ95109.1 - 1.2e-07 31.3 0.0 2.8e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ERZ95109.1 - 1.8e-07 30.5 0.1 2.3e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ERZ95109.1 - 2e-07 30.9 0.0 3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 ERZ95109.1 - 0.00054 19.4 0.1 0.063 12.7 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 ERZ95109.1 - 0.00069 19.7 0.0 0.0011 19.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 ERZ95109.1 - 0.0008 18.6 0.1 0.0017 17.5 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Septin PF00735.13 ERZ95109.1 - 0.0015 17.5 0.6 0.02 13.9 0.0 2.3 2 1 0 2 2 2 1 Septin ATP_bind_1 PF03029.12 ERZ95109.1 - 0.0015 18.0 0.4 0.049 13.1 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.14 ERZ95109.1 - 0.0033 16.9 0.0 0.011 15.1 0.0 1.8 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 ERZ95109.1 - 0.0033 17.1 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_24 PF13479.1 ERZ95109.1 - 0.0063 16.1 0.8 0.0094 15.5 0.1 1.6 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ERZ95109.1 - 0.007 16.0 0.3 0.012 15.3 0.0 1.5 2 0 0 2 2 2 1 Archaeal ATPase AAA_10 PF12846.2 ERZ95109.1 - 0.011 15.1 0.2 0.026 13.9 0.1 1.5 1 1 0 1 1 1 0 AAA-like domain SRPRB PF09439.5 ERZ95109.1 - 0.014 14.5 0.0 0.02 14.1 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.9 ERZ95109.1 - 0.015 14.9 0.1 0.063 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.9 ERZ95109.1 - 0.022 14.4 0.1 0.049 13.3 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 ERZ95109.1 - 0.024 14.6 0.0 0.048 13.6 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain NACHT PF05729.7 ERZ95109.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 ERZ95109.1 - 0.1 12.8 0.1 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 ERZ95109.1 - 0.11 12.3 0.1 0.22 11.4 0.0 1.6 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.22 ERZ95109.1 - 0.18 12.1 0.4 0.24 11.6 0.3 1.7 1 1 0 1 1 1 0 ABC transporter NDUFA12 PF05071.11 ERZ95110.1 - 8.3e-29 100.1 1.3 1e-28 99.8 0.9 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 EamA PF00892.15 ERZ95111.1 - 4.7e-14 52.5 35.6 9.8e-09 35.3 4.9 3.2 3 0 0 3 3 3 2 EamA-like transporter family TPT PF03151.11 ERZ95111.1 - 1.5e-07 31.1 23.2 5.6e-07 29.3 3.9 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 ERZ95111.1 - 6.8e-06 25.2 14.5 1.9e-05 23.7 10.0 1.7 1 1 0 1 1 1 1 UAA transporter family DUF914 PF06027.7 ERZ95111.1 - 1.3e-05 24.2 9.5 1.3e-05 24.2 6.6 1.5 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 ERZ95111.1 - 2.9e-05 24.2 1.2 2.9e-05 24.2 0.8 3.6 3 1 1 4 4 4 2 Multidrug resistance efflux transporter ABC2_membrane_5 PF13346.1 ERZ95111.1 - 2.3 7.4 38.7 0.99 8.6 4.1 3.9 2 1 2 4 4 4 0 ABC-2 family transporter protein FUSC-like PF12805.2 ERZ95111.1 - 2.7 6.8 12.1 0.17 10.7 1.6 2.4 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Amidase_2 PF01510.20 ERZ95112.1 - 0.021 14.8 0.1 0.1 12.6 0.0 1.8 1 1 0 2 2 2 0 N-acetylmuramoyl-L-alanine amidase AAA PF00004.24 ERZ95113.1 - 4.1e-15 56.1 0.0 6.3e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95113.1 - 1.7e-05 24.9 0.0 2.7e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 ERZ95113.1 - 6.4e-05 23.0 0.0 0.00012 22.2 0.0 1.5 1 1 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ERZ95113.1 - 0.00014 22.1 0.1 0.00034 20.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ERZ95113.1 - 0.0002 22.1 0.1 0.00035 21.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ERZ95113.1 - 0.00023 20.2 0.0 0.00031 19.8 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 ERZ95113.1 - 0.00026 19.8 0.0 0.00068 18.4 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_22 PF13401.1 ERZ95113.1 - 0.00035 20.7 0.0 0.00089 19.4 0.0 1.7 1 1 1 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ERZ95113.1 - 0.00039 20.1 0.0 0.00044 20.0 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase DUF815 PF05673.8 ERZ95113.1 - 0.00052 19.0 0.0 0.00083 18.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 ERZ95113.1 - 0.00077 19.1 0.0 0.0026 17.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 ERZ95113.1 - 0.001 19.0 0.0 0.0014 18.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.1 ERZ95113.1 - 0.0017 18.2 0.1 0.0034 17.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.1 ERZ95113.1 - 0.0025 17.4 0.0 0.0042 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ERZ95113.1 - 0.0038 16.9 0.0 0.0055 16.4 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_29 PF13555.1 ERZ95113.1 - 0.0046 16.4 0.0 0.0083 15.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.7 ERZ95113.1 - 0.0051 15.9 0.0 0.0062 15.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_11 PF13086.1 ERZ95113.1 - 0.0061 16.1 0.0 0.013 15.0 0.0 1.7 1 1 1 2 2 2 1 AAA domain T2SE PF00437.15 ERZ95113.1 - 0.0095 14.8 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.1 ERZ95113.1 - 0.0097 16.2 0.1 0.0097 16.2 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_21 PF13304.1 ERZ95113.1 - 0.0098 15.8 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ERZ95113.1 - 0.011 14.9 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 KAP_NTPase PF07693.9 ERZ95113.1 - 0.014 14.4 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.22 ERZ95113.1 - 0.016 15.4 0.2 0.032 14.5 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Miro PF08477.8 ERZ95113.1 - 0.019 15.4 0.1 0.04 14.4 0.0 1.6 2 0 0 2 2 1 0 Miro-like protein DUF2075 PF09848.4 ERZ95113.1 - 0.027 13.4 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 ERZ95113.1 - 0.033 13.6 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 ERZ95113.1 - 0.033 13.3 0.0 0.049 12.7 0.0 1.3 1 0 0 1 1 1 0 KaiC NACHT PF05729.7 ERZ95113.1 - 0.036 13.7 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Bac_DnaA PF00308.13 ERZ95113.1 - 0.062 12.9 0.0 0.087 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein SRPRB PF09439.5 ERZ95113.1 - 0.063 12.4 0.0 0.099 11.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MCM PF00493.18 ERZ95113.1 - 0.083 11.6 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 MCM2/3/5 family AAA_33 PF13671.1 ERZ95113.1 - 0.093 12.6 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ERZ95113.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 ERZ95113.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.1 ERZ95113.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 ERZ95113.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 ERZ95113.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 NTPase Sigma54_activ_2 PF14532.1 ERZ95113.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.5 1 1 1 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 ERZ95113.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cyto_ox_2 PF02322.10 ERZ95114.1 - 3.4 6.7 9.0 3.7 6.6 6.2 1.0 1 0 0 1 1 1 0 Cytochrome oxidase subunit II DUF1700 PF08006.6 ERZ95114.1 - 6.7 5.9 7.0 8.2 5.6 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) AAA PF00004.24 ERZ95115.1 - 3.7e-15 56.2 0.0 8.3e-15 55.1 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95115.1 - 7.5e-06 26.0 0.0 1.1e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ERZ95115.1 - 3.7e-05 22.7 0.0 5.6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 ERZ95115.1 - 8.5e-05 22.7 0.4 0.011 15.8 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ERZ95115.1 - 0.00036 20.8 1.0 0.0013 19.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ERZ95115.1 - 0.00054 20.7 0.1 0.0025 18.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ERZ95115.1 - 0.00071 19.7 1.5 0.0017 18.4 0.0 2.4 2 2 1 3 3 1 1 RNA helicase AAA_5 PF07728.9 ERZ95115.1 - 0.00085 19.0 0.0 0.0044 16.7 0.0 2.0 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ERZ95115.1 - 0.00088 18.0 0.0 0.0018 17.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Arch_ATPase PF01637.13 ERZ95115.1 - 0.001 18.8 1.1 0.0035 17.0 0.0 2.0 2 0 0 2 2 2 1 Archaeal ATPase RuvB_N PF05496.7 ERZ95115.1 - 0.0017 17.4 0.0 0.0033 16.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ERZ95115.1 - 0.0019 17.8 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ERZ95115.1 - 0.0038 16.2 0.1 0.011 14.7 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.7 ERZ95115.1 - 0.0053 15.8 0.0 0.011 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 ERZ95115.1 - 0.0075 16.1 1.5 0.047 13.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ERZ95115.1 - 0.0095 15.4 0.0 0.021 14.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ERZ95115.1 - 0.0097 16.2 4.6 0.045 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 ERZ95115.1 - 0.011 14.9 0.2 0.025 13.7 0.0 1.6 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.1 ERZ95115.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ERZ95115.1 - 0.014 15.3 0.1 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.1 ERZ95115.1 - 0.014 15.0 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Bac_DnaA PF00308.13 ERZ95115.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_11 PF13086.1 ERZ95115.1 - 0.02 14.4 0.1 0.064 12.8 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ERZ95115.1 - 0.022 14.6 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 ERZ95115.1 - 0.027 13.6 0.0 0.048 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MCM PF00493.18 ERZ95115.1 - 0.029 13.1 0.0 0.057 12.2 0.0 1.4 2 0 0 2 2 2 0 MCM2/3/5 family ABC_tran PF00005.22 ERZ95115.1 - 0.032 14.5 0.0 0.071 13.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Glyco_hydro_71 PF03659.9 ERZ95115.1 - 0.036 12.5 1.0 0.055 11.9 0.2 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 71 cobW PF02492.14 ERZ95115.1 - 0.044 13.2 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.12 ERZ95115.1 - 0.058 12.8 0.0 0.19 11.1 0.0 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 ERZ95115.1 - 0.079 12.1 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 ERZ95115.1 - 0.087 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ERZ95115.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.1 ERZ95115.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ERZ95115.1 - 0.11 13.0 0.1 0.34 11.4 0.0 1.9 2 1 0 2 2 1 0 Miro-like protein T2SE PF00437.15 ERZ95115.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_21 PF13304.1 ERZ95115.1 - 0.2 11.5 7.2 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ERZ95117.1 - 1e-15 58.1 0.0 1.5e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ERZ95117.1 - 4.8e-08 33.1 0.0 6.4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ERZ95117.1 - 2e-05 24.8 0.0 3.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ERZ95117.1 - 2.2e-05 24.5 0.0 4.4e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ERZ95117.1 - 2.6e-05 25.0 0.0 4.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ERZ95117.1 - 0.00026 20.7 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase DUF815 PF05673.8 ERZ95117.1 - 0.00041 19.3 0.0 0.00061 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.8 ERZ95117.1 - 0.00043 19.1 0.0 0.00076 18.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_14 PF13173.1 ERZ95117.1 - 0.00053 19.8 0.0 0.00082 19.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ERZ95117.1 - 0.00058 19.6 0.0 0.0019 17.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ERZ95117.1 - 0.00063 19.8 0.0 0.001 19.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ERZ95117.1 - 0.00073 18.6 0.0 0.00089 18.3 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 ERZ95117.1 - 0.00082 19.0 0.0 0.0011 18.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.1 ERZ95117.1 - 0.0017 18.7 0.1 0.0017 18.7 0.1 1.4 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.7 ERZ95117.1 - 0.002 17.2 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 ERZ95117.1 - 0.0021 17.6 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 ERZ95117.1 - 0.0032 17.4 0.2 0.0056 16.6 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_19 PF13245.1 ERZ95117.1 - 0.0063 16.2 0.0 0.0096 15.6 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_29 PF13555.1 ERZ95117.1 - 0.0073 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ERZ95117.1 - 0.012 14.7 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 KAP_NTPase PF07693.9 ERZ95117.1 - 0.013 14.5 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.22 ERZ95117.1 - 0.016 15.5 0.1 0.029 14.6 0.1 1.5 1 1 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.12 ERZ95117.1 - 0.019 14.4 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SE PF00437.15 ERZ95117.1 - 0.021 13.7 0.0 0.032 13.1 0.0 1.3 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_21 PF13304.1 ERZ95117.1 - 0.022 14.7 0.2 0.03 14.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ERZ95117.1 - 0.027 13.4 0.0 0.034 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Miro PF08477.8 ERZ95117.1 - 0.029 14.8 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein Bac_DnaA PF00308.13 ERZ95117.1 - 0.033 13.8 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein NACHT PF05729.7 ERZ95117.1 - 0.035 13.7 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain KaiC PF06745.8 ERZ95117.1 - 0.051 12.6 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.1 ERZ95117.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ERZ95117.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 ERZ95117.1 - 0.1 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_30 PF13604.1 ERZ95117.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ERZ95117.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 NTPase Sigma54_activ_2 PF14532.1 ERZ95117.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.9 ERZ95117.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.16 ERZ95117.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 ERZ95117.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain BTB PF00651.26 ERZ95118.1 - 0.0001 22.2 2.8 0.0049 16.8 0.1 2.9 2 1 1 3 3 3 2 BTB/POZ domain BTB PF00651.26 ERZ95119.1 - 6.1e-18 64.8 0.4 1.2e-17 63.9 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ95119.1 - 1.8e-12 47.4 1.7 4.9e-12 46.0 1.2 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ95119.1 - 0.0078 16.0 1.2 0.056 13.2 0.5 2.6 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF1493 PF07377.7 ERZ95122.1 - 0.07 13.2 0.4 0.13 12.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) DUF4298 PF14131.1 ERZ95122.1 - 0.11 12.3 0.2 0.24 11.3 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) LRR_8 PF13855.1 ERZ95122.1 - 0.15 11.8 4.7 25 4.7 0.0 3.7 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 ERZ95122.1 - 4.5 7.0 7.2 15 5.3 0.0 3.6 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) DDE_1 PF03184.14 ERZ95123.1 - 2.7e-06 26.7 0.0 3.6e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Aconitase PF00330.15 ERZ95126.1 - 0.13 10.7 0.3 0.14 10.5 0.2 1.0 1 0 0 1 1 1 0 Aconitase family (aconitate hydratase) Ion_trans PF00520.26 ERZ95129.1 - 0.017 14.3 2.5 0.037 13.2 1.7 1.5 1 0 0 1 1 1 0 Ion transport protein AAA PF00004.24 ERZ95130.1 - 1.5e-16 60.7 0.0 2.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ERZ95130.1 - 4.9e-06 26.8 0.0 7.9e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 ERZ95130.1 - 1e-05 24.6 0.0 1.3e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ERZ95130.1 - 1.6e-05 24.0 0.0 2.1e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 ERZ95130.1 - 1.8e-05 24.8 0.1 7e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_16 PF13191.1 ERZ95130.1 - 2.3e-05 24.4 0.0 2.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ERZ95130.1 - 2.3e-05 24.5 0.4 0.00073 19.6 0.0 2.4 1 1 2 3 3 3 1 AAA domain AAA_14 PF13173.1 ERZ95130.1 - 4.3e-05 23.4 0.2 0.00053 19.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ERZ95130.1 - 5.7e-05 23.9 0.0 9.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ERZ95130.1 - 7.7e-05 22.4 0.1 0.00071 19.3 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 ERZ95130.1 - 0.00013 21.7 0.2 0.00021 21.0 0.1 1.4 1 1 0 1 1 1 1 Archaeal ATPase TIP49 PF06068.8 ERZ95130.1 - 0.00072 18.3 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus Zeta_toxin PF06414.7 ERZ95130.1 - 0.0009 18.3 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.1 ERZ95130.1 - 0.0035 16.9 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 ERZ95130.1 - 0.0043 17.0 0.4 0.0062 16.4 0.2 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.1 ERZ95130.1 - 0.0046 16.4 0.0 0.0082 15.6 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ERZ95130.1 - 0.0049 17.2 0.2 0.01 16.1 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.1 ERZ95130.1 - 0.0062 16.2 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 ERZ95130.1 - 0.0065 16.0 0.0 0.011 15.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 ERZ95130.1 - 0.0077 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein Sigma54_activ_2 PF14532.1 ERZ95130.1 - 0.0089 16.0 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain KAP_NTPase PF07693.9 ERZ95130.1 - 0.011 14.7 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF258 PF03193.11 ERZ95130.1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MCM PF00493.18 ERZ95130.1 - 0.012 14.4 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family RepL PF05732.6 ERZ95130.1 - 0.015 14.5 0.1 2.9 7.0 0.1 2.1 1 1 1 2 2 2 0 Firmicute plasmid replication protein (RepL) IstB_IS21 PF01695.12 ERZ95130.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein DUF2075 PF09848.4 ERZ95130.1 - 0.022 13.7 0.0 0.05 12.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 ERZ95130.1 - 0.023 14.9 0.1 0.042 14.1 0.1 1.4 1 1 0 1 1 1 0 ABC transporter T2SE PF00437.15 ERZ95130.1 - 0.026 13.4 0.0 0.047 12.5 0.0 1.4 1 1 0 1 1 1 0 Type II/IV secretion system protein KaiC PF06745.8 ERZ95130.1 - 0.026 13.6 0.0 0.041 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC Miro PF08477.8 ERZ95130.1 - 0.029 14.8 0.0 0.067 13.6 0.0 1.7 2 0 0 2 2 1 0 Miro-like protein AAA_21 PF13304.1 ERZ95130.1 - 0.029 14.3 0.4 0.029 14.3 0.3 1.4 2 0 0 2 2 1 0 AAA domain NACHT PF05729.7 ERZ95130.1 - 0.031 13.9 0.0 0.052 13.2 0.0 1.4 1 1 0 1 1 1 0 NACHT domain FeoB_N PF02421.13 ERZ95130.1 - 0.078 12.2 0.2 0.24 10.6 0.0 1.8 1 1 1 2 2 2 0 Ferrous iron transport protein B AAA_33 PF13671.1 ERZ95130.1 - 0.081 12.7 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PIGA PF08288.7 ERZ95130.1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 PIGA (GPI anchor biosynthesis) cobW PF02492.14 ERZ95130.1 - 0.088 12.2 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 ERZ95130.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ERZ95130.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.12 ERZ95130.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NTPase_1 PF03266.10 ERZ95130.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.1 ERZ95130.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 ERZ95130.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF1947 PF09183.5 ERZ95131.1 - 0.025 14.3 0.3 0.077 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Pkinase_Tyr PF07714.12 ERZ95132.1 - 1.1e-12 47.6 0.0 1.2e-12 47.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95132.1 - 2.7e-12 46.3 0.6 2.7e-12 46.3 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ95132.1 - 0.0011 18.7 0.0 0.0013 18.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ95132.1 - 0.011 14.8 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ95132.1 - 0.035 13.4 0.1 0.043 13.1 0.1 1.1 1 0 0 1 1 1 0 RIO1 family MIP-T3 PF10243.4 ERZ95133.1 - 5.8 5.2 55.8 6.5 5.1 38.7 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 ABC_tran PF00005.22 ERZ95134.1 - 7.5e-51 172.0 0.1 1.1e-29 103.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 ERZ95134.1 - 1.4e-49 168.9 45.4 6.6e-26 91.3 7.3 3.5 3 1 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.14 ERZ95134.1 - 6.2e-12 45.2 1.7 4.3e-05 22.8 0.4 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ERZ95134.1 - 2.8e-07 31.0 0.6 0.0029 17.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 ERZ95134.1 - 1.1e-06 28.1 0.0 0.018 14.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 ERZ95134.1 - 1.3e-06 28.6 2.2 0.052 13.7 0.0 3.8 3 1 0 3 3 2 2 AAA domain T2SE PF00437.15 ERZ95134.1 - 3.2e-06 26.2 0.0 0.016 14.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ERZ95134.1 - 1.2e-05 24.8 0.0 0.089 12.2 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_29 PF13555.1 ERZ95134.1 - 1.2e-05 24.6 0.1 0.055 13.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_10 PF12846.2 ERZ95134.1 - 5.2e-05 22.8 1.7 0.36 10.2 0.0 3.1 3 0 0 3 3 3 2 AAA-like domain DUF87 PF01935.12 ERZ95134.1 - 8.2e-05 22.5 1.0 0.092 12.5 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_16 PF13191.1 ERZ95134.1 - 0.00011 22.3 0.2 0.043 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 ERZ95134.1 - 0.00011 22.9 0.1 0.22 12.3 0.0 3.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ERZ95134.1 - 0.00014 22.1 0.0 0.32 11.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ95134.1 - 0.00072 19.4 0.1 2.2 8.2 0.0 3.4 2 1 1 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 ERZ95134.1 - 0.0013 18.6 0.2 0.18 11.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_33 PF13671.1 ERZ95134.1 - 0.0014 18.5 0.4 0.39 10.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ERZ95134.1 - 0.0018 17.4 0.1 0.64 9.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 NACHT PF05729.7 ERZ95134.1 - 0.0023 17.6 0.3 0.53 9.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain MobB PF03205.9 ERZ95134.1 - 0.0029 17.2 0.3 0.95 9.1 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 ERZ95134.1 - 0.004 17.6 0.2 4.8 7.7 0.1 2.9 2 0 0 2 2 2 0 Miro-like protein IstB_IS21 PF01695.12 ERZ95134.1 - 0.0049 16.2 0.0 2.7 7.3 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein Dynamin_N PF00350.18 ERZ95134.1 - 0.0059 16.4 0.2 0.55 10.0 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_5 PF07728.9 ERZ95134.1 - 0.0063 16.2 0.2 4.4 7.0 0.0 3.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ResIII PF04851.10 ERZ95134.1 - 0.0071 16.2 0.2 7.2 6.3 0.0 3.6 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 ERZ95134.1 - 0.0089 16.1 0.2 6.2 7.0 0.0 3.1 3 0 0 3 3 2 0 RNA helicase NB-ARC PF00931.17 ERZ95134.1 - 0.03 13.1 0.3 0.22 10.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Arch_ATPase PF01637.13 ERZ95134.1 - 0.035 13.8 3.1 4.1 7.0 0.0 3.6 4 1 0 4 4 3 0 Archaeal ATPase Mg_chelatase PF01078.16 ERZ95134.1 - 0.041 13.0 0.1 6.3 5.8 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ERZ95134.1 - 0.064 12.3 0.1 11 5.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.21 ERZ95134.1 - 0.079 12.4 0.1 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain DEAD PF00270.24 ERZ95134.1 - 0.082 12.4 0.0 14 5.1 0.0 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase Herpes_UL4 PF03277.8 ERZ95134.1 - 0.087 12.0 0.1 0.18 11.0 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus UL4 family DUF2075 PF09848.4 ERZ95134.1 - 0.11 11.4 0.1 10 4.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.14 ERZ95134.1 - 0.12 11.8 1.5 3.1 7.2 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IPK PF03770.11 ERZ95135.1 - 3.7e-50 170.3 1.4 4.9e-50 169.9 1.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase TRIC PF05197.8 ERZ95136.1 - 4.8e-08 32.6 0.1 7.4e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 TRIC channel UPF0126 PF03458.8 ERZ95136.1 - 0.0001 21.8 3.0 0.41 10.2 1.4 3.3 2 1 0 2 2 2 2 UPF0126 domain Methyltransf_11 PF08241.7 ERZ95137.1 - 1.1e-12 48.2 0.0 2.3e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ95137.1 - 4.7e-10 39.4 0.0 1.7e-09 37.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ95137.1 - 6.9e-09 35.4 0.0 7.4e-08 32.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ95137.1 - 4e-07 30.4 0.1 5e-06 26.9 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ95137.1 - 5.9e-06 26.8 0.0 0.0009 19.8 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ95137.1 - 0.0002 20.4 0.0 0.0028 16.7 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_25 PF13649.1 ERZ95137.1 - 0.005 17.1 0.0 0.025 14.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 ERZ95137.1 - 0.082 11.2 0.0 0.17 10.1 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase zf-MYND PF01753.13 ERZ95138.1 - 1 9.2 9.4 0.081 12.8 2.7 2.1 2 0 0 2 2 2 0 MYND finger Cytochrom_B561 PF03188.11 ERZ95139.1 - 4.4e-18 65.4 9.8 4.4e-18 65.4 6.8 1.8 1 1 1 2 2 2 1 Eukaryotic cytochrome b561 DUF4231 PF14015.1 ERZ95139.1 - 0.026 14.4 8.0 0.7 9.9 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) DUF3619 PF12279.3 ERZ95139.1 - 0.11 12.5 0.8 0.22 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) MnhB PF04039.8 ERZ95139.1 - 0.13 12.2 14.1 1.2 9.2 1.2 3.1 1 1 1 3 3 3 0 Domain related to MnhB subunit of Na+/H+ antiporter Orbi_NS3 PF01616.11 ERZ95139.1 - 0.75 8.7 3.5 0.61 9.0 1.1 1.7 1 1 1 2 2 2 0 Orbivirus NS3 UPF0233 PF06781.7 ERZ95139.1 - 0.75 9.4 8.1 6.3 6.5 0.1 3.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0233) DUF373 PF04123.8 ERZ95139.1 - 2.4 7.1 12.4 3.6 6.5 8.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2306 PF10067.4 ERZ95139.1 - 2.8 8.1 13.4 0.26 11.4 0.8 3.0 2 1 1 3 3 3 0 Predicted membrane protein (DUF2306) CRPA PF05745.6 ERZ95139.1 - 3.3 7.4 9.4 0.28 10.9 1.7 2.5 2 1 1 3 3 3 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) 4HB_MCP_1 PF12729.2 ERZ95139.1 - 4.4 6.6 7.7 14 4.9 0.4 3.4 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction COX2_TM PF02790.10 ERZ95139.1 - 4.9 7.1 12.5 0.5 10.3 1.2 3.2 1 1 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2659 PF10858.3 ERZ95139.1 - 5 6.4 8.3 1 8.6 1.7 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2659) 7TMR-DISM_7TM PF07695.6 ERZ95139.1 - 8.3 6.0 24.8 2.5e+02 1.1 17.2 2.1 1 1 0 1 1 1 0 7TM diverse intracellular signalling DUF2427 PF10348.4 ERZ95139.1 - 8.4 6.0 16.4 0.73 9.4 6.7 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF2427) DXPR_C PF13288.1 ERZ95140.1 - 0.059 13.3 0.1 0.91 9.5 0.0 2.0 1 1 1 2 2 2 0 DXP reductoisomerase C-terminal domain FixQ PF05545.6 ERZ95141.1 - 0.024 14.2 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ RepA1_leader PF08048.7 ERZ95141.1 - 0.093 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Tap RepA1 leader peptide Pkinase_Tyr PF07714.12 ERZ95142.1 - 3.6e-08 32.7 0.1 3.9e-08 32.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95142.1 - 1.4e-05 24.4 0.0 1.7e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TPK_catalytic PF04263.11 ERZ95143.1 - 6.7e-29 99.9 0.0 8.6e-29 99.6 0.0 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain UQ_con PF00179.21 ERZ95144.1 - 5.9e-23 80.8 0.6 1.2e-22 79.7 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Zip PF02535.17 ERZ95144.1 - 8.1e-05 21.7 2.2 9.9e-05 21.4 1.5 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter Pex14_N PF04695.8 ERZ95144.1 - 0.0016 18.5 9.8 0.0016 18.5 6.8 2.0 1 1 1 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF605 PF04652.11 ERZ95144.1 - 0.013 14.9 16.4 0.021 14.2 11.4 1.3 1 0 0 1 1 1 0 Vta1 like zf-RanBP PF00641.13 ERZ95144.1 - 0.033 13.2 1.3 0.066 12.3 0.9 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others SUFU_C PF12470.3 ERZ95144.1 - 0.046 13.3 3.6 0.085 12.4 2.5 1.3 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DUF3984 PF13136.1 ERZ95144.1 - 0.052 12.7 10.7 0.065 12.4 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) DUF3337 PF11816.3 ERZ95144.1 - 0.12 11.7 9.9 0.16 11.3 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF4064 PF13273.1 ERZ95144.1 - 0.33 11.0 3.4 2 8.5 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Neur_chan_memb PF02932.11 ERZ95144.1 - 0.43 10.4 7.7 0.66 9.8 5.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BAF1_ABF1 PF04684.8 ERZ95144.1 - 1.2 7.8 33.7 2.1 7.0 23.4 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Folate_carrier PF01770.13 ERZ95144.1 - 1.4 7.3 3.6 2.1 6.7 2.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier FixO PF02433.10 ERZ95144.1 - 1.6 8.0 7.6 2.4 7.4 5.3 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO DUF2370 PF10176.4 ERZ95144.1 - 1.7 7.9 10.2 4.6 6.5 7.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2370) Macoilin PF09726.4 ERZ95144.1 - 3.5 5.8 15.8 4.6 5.4 10.9 1.2 1 0 0 1 1 1 0 Transmembrane protein Serinc PF03348.10 ERZ95144.1 - 3.8 6.1 5.4 5.4 5.6 3.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) AUX_IAA PF02309.11 ERZ95144.1 - 3.9 7.1 8.7 6.1 6.5 6.0 1.3 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.12 ERZ95144.1 - 6.4 5.4 6.1 8.1 5.1 4.2 1.2 1 0 0 1 1 1 0 Presenilin HTH_Tnp_Tc5 PF03221.11 ERZ95145.1 - 6.8e-07 29.0 0.1 9.3e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ95146.1 - 5.7e-30 104.0 4.1 6.4e-30 103.9 2.8 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4446 PF14584.1 ERZ95147.1 - 2.6 7.8 12.1 0.068 12.9 2.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) FUSC-like PF12805.2 ERZ95149.1 - 0.18 10.6 1.3 1.8 7.4 0.0 2.5 2 1 1 3 3 3 0 FUSC-like inner membrane protein yccS DUF4446 PF14584.1 ERZ95149.1 - 1.5 8.6 6.5 2.3 8.0 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF948 PF06103.6 ERZ95149.1 - 1.5 8.7 3.8 5.2 7.0 2.6 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lge1 PF11488.3 ERZ95150.1 - 0.027 14.6 1.8 0.11 12.6 1.2 2.1 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 FliG_N PF14842.1 ERZ95150.1 - 0.041 14.0 0.6 0.11 12.6 0.4 1.7 1 0 0 1 1 1 0 FliG N-terminal domain FliT PF05400.8 ERZ95150.1 - 0.66 10.4 4.3 2.3 8.6 1.9 2.3 2 0 0 2 2 2 0 Flagellar protein FliT DUF1283 PF06932.6 ERZ95150.1 - 3.5 7.7 14.0 0.53 10.3 3.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1283) bZIP_2 PF07716.10 ERZ95153.1 - 0.88 9.4 8.2 1.5 8.6 1.6 2.1 2 0 0 2 2 2 0 Basic region leucine zipper Myb_DNA-binding PF00249.26 ERZ95155.1 - 5.9e-43 144.6 11.7 5.7e-09 35.8 0.1 5.3 5 0 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ95155.1 - 4.4e-31 106.7 21.1 1.3e-09 37.9 0.1 5.4 4 1 1 5 5 5 5 Myb-like DNA-binding domain Rap1_C PF11626.3 ERZ95155.1 - 0.0077 16.0 1.6 0.19 11.6 0.0 2.9 1 1 1 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Mistic PF11458.3 ERZ95155.1 - 0.011 16.0 1.2 4.1 7.8 0.0 3.8 3 2 2 5 5 5 0 Membrane-integrating protein Mistic BTV_NS2 PF04514.7 ERZ95156.1 - 0.21 10.4 3.2 0.22 10.3 2.2 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 MFMR PF07777.6 ERZ95156.1 - 3.6 7.4 7.4 4.2 7.2 5.1 1.1 1 0 0 1 1 1 0 G-box binding protein MFMR Toxin_27 PF08099.6 ERZ95158.1 - 0.11 12.4 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Scorpion calcine family Caudo_TAP PF02413.12 ERZ95158.1 - 0.52 10.4 4.2 0.94 9.6 2.9 1.4 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein ARGLU PF15346.1 ERZ95158.1 - 4 7.2 12.6 28 4.4 8.8 1.9 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 DUF2098 PF09871.4 ERZ95158.1 - 9.7 6.2 10.2 0.4 10.6 1.8 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) Sel1 PF08238.7 ERZ95159.1 - 1.3e-41 140.1 9.4 4.5e-11 43.0 0.4 4.2 4 0 0 4 4 4 4 Sel1 repeat MIT PF04212.13 ERZ95159.1 - 0.00015 21.5 17.5 0.032 14.1 1.8 4.6 1 1 3 4 4 4 3 MIT (microtubule interacting and transport) domain MTBP_C PF14920.1 ERZ95159.1 - 0.00068 19.1 0.2 0.019 14.4 0.0 2.6 2 1 1 3 3 3 1 MDM2-binding TPR_12 PF13424.1 ERZ95159.1 - 0.04 13.8 11.6 0.054 13.4 0.6 3.7 1 1 2 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 ERZ95159.1 - 0.95 10.2 8.5 81 4.5 0.1 4.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat ATP-synt_DE PF00401.15 ERZ95159.1 - 0.96 9.3 9.4 16 5.4 0.1 4.1 4 0 0 4 4 4 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PG_binding_2 PF08823.6 ERZ95159.1 - 1.8 8.7 6.3 7.4 6.7 1.0 3.0 1 1 1 2 2 2 0 Putative peptidoglycan binding domain Surfac_D-trimer PF09006.6 ERZ95159.1 - 2 8.2 4.2 49 3.7 0.1 3.4 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation CaM_bdg_C0 PF10562.4 ERZ95159.1 - 7 6.5 6.6 35 4.3 0.1 3.2 3 0 0 3 3 3 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit F-box-like PF12937.2 ERZ95160.1 - 9.8e-06 25.2 2.5 2.3e-05 23.9 1.7 1.7 1 0 0 1 1 1 1 F-box-like ubiquitin PF00240.18 ERZ95161.1 - 7.5e-35 118.1 0.6 8.5e-35 117.9 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ95161.1 - 1.2e-20 72.8 0.7 1.4e-20 72.7 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ95161.1 - 6.3e-07 29.5 0.1 2.3e-06 27.7 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ERZ95161.1 - 2.2e-05 24.2 0.0 2.5e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 ERZ95161.1 - 0.00019 21.3 0.1 0.00041 20.2 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ERZ95161.1 - 0.0015 18.6 0.1 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TUG-UBL1 PF11470.3 ERZ95161.1 - 0.015 15.2 0.1 0.018 14.9 0.1 1.2 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Plexin_cytopl PF08337.7 ERZ95161.1 - 0.036 12.3 1.2 0.59 8.3 0.3 2.0 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain FERM_N PF09379.5 ERZ95161.1 - 0.065 13.3 0.5 0.32 11.0 0.4 1.9 1 1 0 1 1 1 0 FERM N-terminal domain GCR1_C PF12550.3 ERZ95162.1 - 1.6e-14 53.5 0.0 3.1e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes polyprenyl_synt PF00348.12 ERZ95163.1 - 5.8e-57 192.4 0.0 6.9e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase Zip PF02535.17 ERZ95164.1 - 1.7e-37 129.1 10.2 3.1e-37 128.2 7.2 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter N2227 PF07942.7 ERZ95165.1 - 5.6e-106 353.4 0.1 7.4e-106 353.0 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 ERZ95165.1 - 5.4e-06 26.2 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ95165.1 - 0.002 18.5 0.0 0.0085 16.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Baculo_p24 PF05073.7 ERZ95165.1 - 0.073 12.6 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Alpha_kinase PF02816.13 ERZ95166.1 - 4.4e-35 121.0 0.3 6e-35 120.6 0.2 1.2 1 0 0 1 1 1 1 Alpha-kinase family Alpha_kinase PF02816.13 ERZ95167.1 - 8.9e-23 80.9 0.4 2e-22 79.7 0.3 1.5 1 1 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ERZ95167.1 - 1.5e-07 31.7 0.0 2.1e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ERZ95167.1 - 0.0084 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Spc97_Spc98 PF04130.8 ERZ95169.1 - 9.6e-78 261.8 20.8 1.6e-77 261.0 14.4 1.4 1 0 0 1 1 1 1 Spc97 / Spc98 family DUF943 PF06092.7 ERZ95170.1 - 0.017 14.4 0.2 0.019 14.2 0.1 1.1 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) DUF3636 PF12331.3 ERZ95171.1 - 0.087 12.4 0.2 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) zf-CCHC PF00098.18 ERZ95172.1 - 0.0075 16.1 3.7 0.0075 16.1 2.6 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C2H2_3 PF13878.1 ERZ95175.1 - 0.51 9.9 2.8 0.67 9.5 0.2 2.3 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Mod_r PF07200.8 ERZ95177.1 - 0.069 13.0 1.6 0.35 10.7 1.1 2.0 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Multi-haem_cyto PF13447.1 ERZ95178.1 - 0.012 14.6 0.1 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 Seven times multi-haem cytochrome CxxCH Retrotrans_gag PF03732.12 ERZ95181.1 - 2.3e-05 24.3 0.0 0.00012 22.0 0.0 2.3 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4148 PF13663.1 ERZ95181.1 - 0.076 12.8 0.0 0.67 9.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) HMG_box PF00505.14 ERZ95183.1 - 5e-06 26.6 0.1 8.2e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ95183.1 - 2.8e-05 24.4 0.0 5.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain WG_beta_rep PF14903.1 ERZ95183.1 - 0.19 12.0 1.3 1.5 9.2 0.1 2.4 2 0 0 2 2 2 0 WG containing repeat RGS PF00615.14 ERZ95185.1 - 0.087 12.9 0.5 2.9 7.9 0.3 3.1 1 1 0 1 1 1 0 Regulator of G protein signaling domain PLD_C PF12357.3 ERZ95185.1 - 1.7 8.2 3.8 50 3.5 0.0 4.4 3 2 2 5 5 5 0 Phospholipase D C terminal Ribosomal_L5_C PF00673.16 ERZ95185.1 - 2.9 7.6 5.2 1.9 8.2 0.2 2.7 2 1 1 3 3 3 0 ribosomal L5P family C-terminus SDA1 PF05285.7 ERZ95187.1 - 1.1 8.4 6.8 1.2 8.3 4.7 1.1 1 0 0 1 1 1 0 SDA1 Reticulon PF02453.12 ERZ95188.1 - 3.9e-27 94.9 2.9 3.9e-27 94.9 2.0 1.8 2 0 0 2 2 2 1 Reticulon DUF639 PF04842.7 ERZ95188.1 - 1.3e-06 26.9 0.1 1.7e-06 26.5 0.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) DUF3810 PF12725.2 ERZ95188.1 - 0.038 12.8 2.1 0.12 11.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) UPF0270 PF06794.7 ERZ95191.1 - 0.066 12.9 2.2 0.13 12.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0270) Pox_D5 PF03288.11 ERZ95192.1 - 6.4e-07 29.5 0.0 1.7e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Poxvirus D5 protein-like S-antigen PF05756.6 ERZ95193.1 - 0.027 14.4 0.4 0.049 13.6 0.3 1.4 1 0 0 1 1 1 0 S-antigen protein Phage_X PF05155.10 ERZ95194.1 - 0.0021 17.9 0.3 2 8.4 0.1 2.2 2 0 0 2 2 2 2 Phage X family BLOC1_2 PF10046.4 ERZ95195.1 - 0.00023 21.2 0.6 0.00055 20.0 0.4 1.5 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.7 ERZ95195.1 - 0.0077 16.0 0.3 0.01 15.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Streptin-Immun PF11083.3 ERZ95195.1 - 0.01 15.7 0.7 0.25 11.3 0.1 2.4 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein Toxin_trans PF07952.7 ERZ95195.1 - 0.018 13.9 0.0 0.022 13.6 0.0 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain HalX PF08663.5 ERZ95195.1 - 0.019 14.9 2.4 0.26 11.2 0.2 2.4 1 1 1 2 2 2 0 HalX domain DUF2461 PF09365.5 ERZ95195.1 - 0.022 14.1 0.1 0.031 13.6 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) MtrG PF04210.8 ERZ95195.1 - 0.025 14.2 0.3 0.092 12.4 0.1 2.1 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G UCR_hinge PF02320.11 ERZ95195.1 - 0.028 14.3 0.4 0.34 10.8 0.1 2.2 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DUF342 PF03961.8 ERZ95195.1 - 0.034 12.5 0.1 0.037 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ALIX_LYPXL_bnd PF13949.1 ERZ95195.1 - 0.05 12.5 0.4 0.072 12.0 0.3 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV TMCO5 PF14992.1 ERZ95195.1 - 0.088 11.9 0.9 0.11 11.6 0.6 1.1 1 0 0 1 1 1 0 TMCO5 family Lzipper-MIP1 PF14389.1 ERZ95195.1 - 0.092 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 FH2 PF02181.18 ERZ95195.1 - 0.11 11.3 0.1 0.14 11.0 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain Phage_X PF05155.10 ERZ95197.1 - 0.1 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Phage X family ABC_tran PF00005.22 ERZ95198.1 - 2e-42 144.7 6.8 1.3e-20 74.0 0.0 4.1 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 ERZ95198.1 - 2.9e-14 53.6 15.3 1.7e-06 28.2 1.7 4.8 4 1 0 4 4 4 2 AAA domain SMC_N PF02463.14 ERZ95198.1 - 9.5e-13 47.8 6.0 8e-07 28.5 0.7 3.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_tran_2 PF12848.2 ERZ95198.1 - 4.8e-08 32.7 8.5 4.8e-08 32.7 5.9 2.7 2 0 0 2 2 1 1 ABC transporter AAA_23 PF13476.1 ERZ95198.1 - 1.7e-06 28.5 7.0 1.7e-06 28.5 4.8 4.2 3 1 1 4 4 4 1 AAA domain AAA_25 PF13481.1 ERZ95198.1 - 1.6e-05 24.3 0.2 0.01 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ERZ95198.1 - 2.5e-05 23.6 1.4 0.14 11.6 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ERZ95198.1 - 0.0002 20.5 0.4 0.59 9.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA PF00004.24 ERZ95198.1 - 0.0008 19.6 6.2 0.19 11.9 0.1 3.7 5 1 0 5 5 2 2 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 ERZ95198.1 - 0.0032 17.3 0.0 0.73 9.7 0.0 2.9 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.17 ERZ95198.1 - 0.0036 17.4 0.1 0.85 9.8 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_15 PF13175.1 ERZ95198.1 - 0.006 15.6 0.4 0.006 15.6 0.3 5.6 3 1 2 6 6 6 2 AAA ATPase domain NACHT PF05729.7 ERZ95198.1 - 0.013 15.1 0.7 4.5 6.8 0.0 3.4 3 0 0 3 3 3 0 NACHT domain AAA_22 PF13401.1 ERZ95198.1 - 0.023 14.8 6.0 5.9 7.0 0.0 4.1 3 2 0 4 4 4 0 AAA domain MMR_HSR1 PF01926.18 ERZ95198.1 - 0.027 14.4 4.1 7.6 6.5 0.6 3.6 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_17 PF13207.1 ERZ95198.1 - 0.029 15.1 7.3 3 8.6 0.0 3.7 4 1 0 4 4 3 0 AAA domain ArgK PF03308.11 ERZ95198.1 - 0.086 11.5 4.9 0.56 8.9 0.0 2.7 3 0 0 3 3 3 0 ArgK protein AAA_10 PF12846.2 ERZ95198.1 - 1.2 8.4 8.3 6.3 6.1 2.5 2.7 2 1 0 2 2 2 0 AAA-like domain MobB PF03205.9 ERZ95198.1 - 2.2 7.9 10.3 9.2 5.9 0.0 3.8 3 1 1 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B F-box-like PF12937.2 ERZ95200.1 - 1.8e-07 30.7 0.3 5.7e-07 29.1 0.2 1.9 1 0 0 1 1 1 1 F-box-like FTH PF01827.22 ERZ95200.1 - 0.003 17.1 0.2 0.011 15.3 0.1 1.9 1 0 0 1 1 1 1 FTH domain LRR_4 PF12799.2 ERZ95200.1 - 0.016 14.8 6.3 0.26 10.9 1.1 3.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) AIG1 PF04548.11 ERZ95201.1 - 1.9e-64 216.6 5.1 1.2e-31 109.5 0.0 2.7 3 0 0 3 3 3 2 AIG1 family MMR_HSR1 PF01926.18 ERZ95201.1 - 7.7e-25 87.1 1.2 1.8e-11 44.0 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase Hint PF01079.15 ERZ95201.1 - 1.5e-21 76.6 0.0 2.8e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Hint module DUF258 PF03193.11 ERZ95201.1 - 1.2e-12 47.3 0.0 5.3e-05 22.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 ERZ95201.1 - 6.8e-10 39.1 0.0 0.0007 19.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain FeoB_N PF02421.13 ERZ95201.1 - 7.6e-09 35.0 0.3 0.0031 16.8 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B Septin PF00735.13 ERZ95201.1 - 5.7e-08 32.0 0.2 0.0073 15.3 0.0 3.1 2 0 0 2 2 2 2 Septin GTP_EFTU PF00009.22 ERZ95201.1 - 2.1e-07 30.6 0.2 0.037 13.4 0.0 3.2 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ERZ95201.1 - 2.6e-07 30.0 1.4 0.013 15.0 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 ERZ95201.1 - 5.6e-07 29.7 0.0 0.0077 16.2 0.0 3.0 2 0 0 2 2 2 2 AAA ATPase domain SRPRB PF09439.5 ERZ95201.1 - 7.2e-07 28.6 8.1 0.0021 17.3 0.1 3.4 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA_10 PF12846.2 ERZ95201.1 - 9.6e-07 28.5 10.8 0.008 15.6 2.6 3.1 2 2 0 2 2 2 2 AAA-like domain RNA_helicase PF00910.17 ERZ95201.1 - 1e-06 28.8 0.0 0.022 14.9 0.0 2.6 2 0 0 2 2 2 2 RNA helicase T2SE PF00437.15 ERZ95201.1 - 1.5e-06 27.2 0.1 0.05 12.4 0.1 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_33 PF13671.1 ERZ95201.1 - 1.2e-05 25.2 0.0 0.086 12.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ERZ95201.1 - 4e-05 22.7 0.4 0.33 10.0 0.0 3.1 3 0 0 3 3 3 2 Zeta toxin AAA_18 PF13238.1 ERZ95201.1 - 6.9e-05 23.1 0.4 0.02 15.1 0.0 5.6 4 2 1 5 5 4 2 AAA domain ABC_tran PF00005.22 ERZ95201.1 - 7e-05 23.1 14.5 0.016 15.5 0.0 4.0 4 1 0 4 4 3 2 ABC transporter Gtr1_RagA PF04670.7 ERZ95201.1 - 8.7e-05 21.7 0.4 0.29 10.2 0.0 2.8 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 ERZ95201.1 - 8.9e-05 22.3 21.1 2.2 8.1 0.0 6.2 4 2 2 6 6 6 3 Dynamin family MobB PF03205.9 ERZ95201.1 - 0.00048 19.8 0.2 0.52 10.0 0.0 2.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.21 ERZ95201.1 - 0.00053 19.4 0.0 0.58 9.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Miro PF08477.8 ERZ95201.1 - 0.00062 20.2 5.8 0.21 12.0 0.0 3.8 3 1 0 3 3 2 2 Miro-like protein TrwB_AAD_bind PF10412.4 ERZ95201.1 - 0.00071 18.3 0.0 0.25 9.9 0.0 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.24 ERZ95201.1 - 0.0016 18.6 1.0 5.2 7.2 0.0 4.0 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 ERZ95201.1 - 0.0018 17.8 0.0 0.54 9.9 0.0 2.7 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_5 PF07728.9 ERZ95201.1 - 0.004 16.8 0.0 3.5 7.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ERZ95201.1 - 0.0066 16.3 0.3 3.2 7.6 0.0 3.2 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 ERZ95201.1 - 0.016 14.6 4.3 0.73 9.2 0.1 3.7 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ERZ95201.1 - 0.022 14.2 7.0 1.7 8.1 0.4 3.4 2 2 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 ERZ95201.1 - 0.041 14.7 19.3 7.3 7.4 3.7 4.7 2 2 0 2 2 2 0 AAA domain CPT PF07931.7 ERZ95201.1 - 0.063 12.9 0.0 5.6 6.5 0.0 2.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DinB PF05163.7 ERZ95201.1 - 0.093 12.4 6.5 0.79 9.4 0.5 2.7 2 1 1 3 3 3 0 DinB family AAA_25 PF13481.1 ERZ95201.1 - 0.096 12.0 0.2 15 4.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ95201.1 - 0.21 11.0 11.1 0.49 9.8 0.0 3.1 4 0 0 4 4 3 0 FtsK/SpoIIIE family DUF87 PF01935.12 ERZ95201.1 - 0.68 9.7 0.0 0.68 9.7 0.0 4.4 4 0 0 4 4 3 0 Domain of unknown function DUF87 DUF4207 PF13904.1 ERZ95201.1 - 0.78 9.0 25.8 0.24 10.7 6.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) SRP54 PF00448.17 ERZ95201.1 - 1.2 8.5 4.6 5.1 6.4 0.1 3.4 2 2 1 3 3 3 0 SRP54-type protein, GTPase domain DUF4407 PF14362.1 ERZ95201.1 - 6 5.7 14.0 0.44 9.4 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) NEAT PF05031.7 ERZ95202.1 - 0.0026 17.7 1.6 0.37 10.8 0.3 2.2 2 0 0 2 2 2 2 Iron Transport-associated domain RHD3 PF05879.7 ERZ95204.1 - 1.7e-08 32.9 9.4 1.7e-07 29.6 0.0 3.5 3 0 0 3 3 3 2 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.18 ERZ95204.1 - 5.7e-07 29.4 0.0 0.00076 19.4 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ95204.1 - 1.4e-05 24.9 8.2 0.0027 17.5 0.0 3.8 4 0 0 4 4 4 2 Dynamin family AAA_28 PF13521.1 ERZ95204.1 - 0.0014 18.6 0.0 0.96 9.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 ERZ95204.1 - 0.0072 16.8 0.0 2.6 8.5 0.0 3.6 3 0 0 3 3 3 1 Miro-like protein AAA_29 PF13555.1 ERZ95204.1 - 0.015 14.8 0.0 1.5 8.4 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.22 ERZ95204.1 - 0.13 12.5 2.1 8.6 6.6 0.0 3.3 3 0 0 3 3 3 0 ABC transporter RRP14 PF15459.1 ERZ95205.1 - 0.076 13.0 2.4 0.35 10.9 0.6 2.2 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Aa_trans PF01490.13 ERZ95206.1 - 5.4e-58 196.4 40.6 6.2e-58 196.2 28.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Vpu PF00558.14 ERZ95206.1 - 0.25 10.9 2.8 2.5 7.7 0.1 2.5 2 0 0 2 2 2 0 Vpu protein Pkinase_Tyr PF07714.12 ERZ95207.1 - 8.6e-12 44.6 0.5 1.7e-07 30.5 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95207.1 - 2.3e-11 43.3 0.3 5.2e-09 35.6 0.2 2.3 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ERZ95207.1 - 0.029 14.0 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF659 PF04937.10 ERZ95210.1 - 0.00037 20.0 0.2 0.00081 18.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF3505 PF12013.3 ERZ95210.1 - 0.0012 19.0 0.2 0.0031 17.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3505) zf-SAP30 PF13866.1 ERZ95210.1 - 0.0064 16.1 1.0 0.025 14.2 0.0 2.5 3 0 0 3 3 3 1 SAP30 zinc-finger DUF3535 PF12054.3 ERZ95211.1 - 3.4e-118 395.0 1.2 8.3e-117 390.4 0.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 ERZ95211.1 - 3.5e-77 259.1 0.0 5.7e-77 258.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 ERZ95211.1 - 2.4e-15 55.1 11.9 1 9.6 0.0 10.6 9 0 0 9 9 9 6 HEAT repeat Helicase_C PF00271.26 ERZ95211.1 - 5.1e-13 48.6 0.0 1.5e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT_2 PF13646.1 ERZ95211.1 - 1.3e-07 31.7 4.2 0.02 15.1 0.1 6.5 6 1 1 7 7 7 2 HEAT repeats CLASP_N PF12348.3 ERZ95211.1 - 7.5e-07 28.7 3.2 4e-06 26.3 0.1 3.6 4 0 0 4 4 4 1 CLASP N terminal HEAT_EZ PF13513.1 ERZ95211.1 - 1e-06 29.0 7.6 0.85 10.1 0.1 7.2 6 0 0 6 6 6 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ERZ95211.1 - 1.4e-06 28.6 7.1 0.031 14.6 0.1 5.0 4 1 1 5 5 5 3 Vacuolar 14 Fab1-binding region DUF1546 PF07571.8 ERZ95211.1 - 0.00051 20.0 0.1 3.5 7.8 0.0 4.9 5 0 0 5 5 5 1 Protein of unknown function (DUF1546) adh_short PF00106.20 ERZ95212.1 - 1.8e-20 73.4 0.1 2.8e-20 72.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ95212.1 - 3.5e-08 33.3 0.1 5.6e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ERZ95212.1 - 2.9e-07 30.5 0.2 2.7e-06 27.3 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ERZ95212.1 - 6.8e-05 22.4 0.3 0.00011 21.6 0.2 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ERZ95212.1 - 0.015 15.3 0.1 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 NADH(P)-binding YjeF_N PF03853.10 ERZ95212.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Nramp PF01566.13 ERZ95213.1 - 4.6e-117 390.8 14.1 4.6e-117 390.8 9.7 1.4 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein DUF4007 PF13182.1 ERZ95214.1 - 0.038 12.8 1.5 0.08 11.7 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4007) MscS_porin PF12795.2 ERZ95214.1 - 0.2 10.9 6.2 0.082 12.2 0.7 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF3571 PF12095.3 ERZ95214.1 - 0.36 11.0 2.2 3 8.1 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3571) Seryl_tRNA_N PF02403.17 ERZ95214.1 - 6.9 6.7 11.5 6.5 6.8 0.4 3.4 4 1 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.6 ERZ95215.1 - 0.007 16.7 3.0 0.23 11.8 0.1 2.7 2 0 0 2 2 2 1 Syntaxin 6, N-terminal ROK PF00480.15 ERZ95215.1 - 0.018 14.8 1.3 0.038 13.8 0.3 2.0 1 1 1 2 2 2 0 ROK family DUF2797 PF10977.3 ERZ95215.1 - 0.032 13.8 0.3 0.032 13.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2797) Nro1 PF12753.2 ERZ95215.1 - 0.035 13.0 4.5 0.25 10.2 1.3 2.2 2 1 0 2 2 2 0 Nuclear pore complex subunit Nro1 ING PF12998.2 ERZ95215.1 - 0.043 14.0 4.1 1.5 9.1 0.4 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding BLYB PF05289.6 ERZ95215.1 - 0.061 13.1 0.2 0.061 13.1 0.1 2.2 3 0 0 3 3 3 0 Borrelia hemolysin accessory protein DUF2431 PF10354.4 ERZ95215.1 - 0.14 12.1 2.0 1.6 8.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) Phasin PF05597.6 ERZ95215.1 - 0.29 10.9 4.5 6.4 6.5 0.1 2.7 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) IncA PF04156.9 ERZ95215.1 - 0.33 10.5 0.0 0.33 10.5 0.0 2.7 2 1 1 3 3 3 0 IncA protein CRISPR_Cas2 PF09827.4 ERZ95215.1 - 0.41 10.8 4.1 0.32 11.1 0.3 2.5 3 0 0 3 3 3 0 CRISPR associated protein Cas2 Prominin PF05478.6 ERZ95215.1 - 0.6 7.5 5.8 0.069 10.6 0.4 1.8 2 0 0 2 2 2 0 Prominin Syntaxin PF00804.20 ERZ95215.1 - 3.2 7.9 10.6 0.4 10.8 0.4 2.9 3 0 0 3 3 3 0 Syntaxin DUF4473 PF14747.1 ERZ95215.1 - 6.3 7.1 12.2 0.23 11.7 0.8 3.5 3 2 2 5 5 5 0 Domain of unknown function (DUF4473) DUF3784 PF12650.2 ERZ95217.1 - 0.013 15.4 0.5 0.03 14.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) EzrA PF06160.7 ERZ95217.1 - 0.068 11.3 15.3 0.054 11.6 3.0 2.6 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA ATG22 PF11700.3 ERZ95217.1 - 0.12 10.7 0.0 0.16 10.4 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like DUF2970 PF11174.3 ERZ95217.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) DUF869 PF05911.6 ERZ95217.1 - 4 5.5 13.2 0.43 8.7 2.7 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) DivIC PF04977.10 ERZ95217.1 - 8.8 5.8 10.4 0.24 10.8 0.3 3.3 2 2 2 4 4 4 0 Septum formation initiator Apolipoprotein PF01442.13 ERZ95218.1 - 0.0092 15.5 0.1 1.7 8.1 0.0 2.4 2 0 0 2 2 2 2 Apolipoprotein A1/A4/E domain ApoL PF05461.6 ERZ95218.1 - 0.33 10.1 9.6 0.047 12.9 3.0 2.1 2 1 0 2 2 2 0 Apolipoprotein L AAA PF00004.24 ERZ95219.1 - 5.4e-11 42.8 0.6 3.9e-05 23.8 0.0 4.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) CBM_20 PF00686.14 ERZ95219.1 - 7.7e-05 22.2 0.1 0.00022 20.7 0.0 1.8 1 0 0 1 1 1 1 Starch binding domain AAA_5 PF07728.9 ERZ95219.1 - 0.00012 21.8 0.0 0.0037 16.9 0.0 3.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Miro PF08477.8 ERZ95219.1 - 0.0037 17.7 0.0 0.034 14.6 0.0 2.8 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 ERZ95219.1 - 0.0053 16.9 0.0 2.7 8.1 0.0 3.9 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.1 ERZ95219.1 - 0.0095 15.9 0.0 1.5 8.8 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain Uso1_p115_head PF04869.9 ERZ95222.1 - 2.7e-78 262.8 0.0 4.9e-78 262.0 0.0 1.5 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 ERZ95222.1 - 2.5e-09 37.1 21.0 2.5e-09 37.1 14.6 1.7 2 0 0 2 2 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region IncA PF04156.9 ERZ95222.1 - 4.2e-06 26.4 8.8 9e-06 25.4 6.1 1.6 1 0 0 1 1 1 1 IncA protein Spc7 PF08317.6 ERZ95222.1 - 0.00013 20.7 11.3 0.00023 19.9 7.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein CCDC-167 PF15188.1 ERZ95222.1 - 0.00045 20.0 5.8 0.00045 20.0 4.1 2.4 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 167 ATG16 PF08614.6 ERZ95222.1 - 0.00065 19.5 8.3 0.0015 18.3 5.7 1.5 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF2435 PF10363.4 ERZ95222.1 - 0.0009 19.0 1.7 3.8 7.4 0.1 3.9 3 0 0 3 3 3 1 Protein of unknown function (DUF2435) BicD PF09730.4 ERZ95222.1 - 0.0014 17.0 7.7 0.0021 16.5 5.3 1.1 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D MAD PF05557.8 ERZ95222.1 - 0.0022 16.1 8.5 0.0031 15.7 5.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein GAS PF13851.1 ERZ95222.1 - 0.0047 16.1 9.0 0.01 15.0 6.3 1.5 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding SlyX PF04102.7 ERZ95222.1 - 0.017 15.4 11.2 0.57 10.5 0.3 2.9 1 1 0 2 2 2 0 SlyX TBPIP PF07106.8 ERZ95222.1 - 0.03 13.8 15.6 0.054 13.0 5.5 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMCO5 PF14992.1 ERZ95222.1 - 0.036 13.1 10.8 0.083 12.0 7.5 1.5 1 0 0 1 1 1 0 TMCO5 family FlaC_arch PF05377.6 ERZ95222.1 - 0.066 13.1 9.4 0.43 10.4 1.3 3.6 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.7 ERZ95222.1 - 0.18 11.5 13.9 0.06 13.0 5.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.4 ERZ95222.1 - 0.2 11.5 12.3 0.43 10.4 8.5 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2968 PF11180.3 ERZ95222.1 - 0.2 10.9 7.1 0.43 9.9 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Tup_N PF08581.5 ERZ95222.1 - 0.25 11.5 12.0 0.4 10.8 3.6 2.7 1 1 1 2 2 2 0 Tup N-terminal Bacillus_HBL PF05791.6 ERZ95222.1 - 0.35 10.2 15.8 0.27 10.6 7.4 3.1 3 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Striatin PF08232.7 ERZ95222.1 - 0.5 10.6 8.0 1.3 9.3 5.6 1.6 1 0 0 1 1 1 0 Striatin family FliJ PF02050.11 ERZ95222.1 - 0.57 10.2 11.2 2.7 8.0 6.5 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein Nup54 PF13874.1 ERZ95222.1 - 0.62 9.7 5.3 2.5 7.7 0.1 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 ADIP PF11559.3 ERZ95222.1 - 0.64 9.9 13.0 2.8 7.8 9.0 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.3 ERZ95222.1 - 0.7 9.7 21.3 2.8 7.8 9.1 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4200 PF13863.1 ERZ95222.1 - 0.88 9.5 11.5 1.9 8.4 8.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DivIC PF04977.10 ERZ95222.1 - 1 8.8 20.4 0.44 10.0 1.2 3.8 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.1 ERZ95222.1 - 3.3 6.5 7.9 6.9 5.5 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4140 PF13600.1 ERZ95222.1 - 5.5 7.4 9.8 13 6.2 2.5 2.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) HR1 PF02185.11 ERZ95222.1 - 6 6.6 14.1 0.93 9.2 3.0 3.2 2 1 1 3 3 3 0 Hr1 repeat USP8_interact PF08941.5 ERZ95222.1 - 6.3 6.0 6.7 30 3.8 2.8 2.8 2 1 1 3 3 3 0 USP8 interacting Spc24 PF08286.6 ERZ95222.1 - 7.3 6.3 17.3 0.31 10.7 2.8 2.8 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Mnd1 PF03962.10 ERZ95222.1 - 7.8 6.1 14.6 5.2 6.6 2.5 2.5 2 1 0 2 2 2 0 Mnd1 family Med9 PF07544.8 ERZ95222.1 - 8.8 6.1 12.8 1.7 8.4 1.1 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fibrillarin PF01269.12 ERZ95224.1 - 6.2e-111 368.8 0.1 7.5e-111 368.5 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin Methyltransf_31 PF13847.1 ERZ95224.1 - 0.00057 19.5 0.0 0.00079 19.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.5 ERZ95224.1 - 0.0013 18.2 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit DREV PF05219.7 ERZ95224.1 - 0.025 13.4 0.0 0.055 12.3 0.0 1.5 1 1 1 2 2 2 0 DREV methyltransferase RRP7 PF12923.2 ERZ95225.1 - 7e-40 136.0 7.1 7e-40 136.0 4.9 3.1 3 0 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) RRM_1 PF00076.17 ERZ95225.1 - 6.1e-06 25.7 0.0 0.0015 18.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ95225.1 - 0.00036 20.4 0.0 0.0019 18.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NST1 PF13945.1 ERZ95225.1 - 0.0014 18.7 0.8 0.0014 18.7 0.5 2.6 3 0 0 3 3 3 2 Salt tolerance down-regulator PsbU PF06514.6 ERZ95226.1 - 0.052 13.3 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) V-set PF07686.12 ERZ95226.1 - 0.063 13.1 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin V-set domain CTP_transf_2 PF01467.21 ERZ95226.1 - 0.074 13.1 0.1 0.085 12.9 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase HHH_6 PF14579.1 ERZ95226.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Lipoxygenase PF00305.14 ERZ95228.1 - 0.037 12.0 1.2 0.038 11.9 0.9 1.1 1 0 0 1 1 1 0 Lipoxygenase Amidohydro_1 PF01979.15 ERZ95229.1 - 3.6e-62 210.9 5.1 6.5e-62 210.1 3.5 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 ERZ95229.1 - 9.2e-56 187.1 1.5 1.9e-55 186.1 1.0 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.15 ERZ95229.1 - 1.1e-41 140.7 0.0 2.3e-41 139.6 0.0 1.6 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.13 ERZ95229.1 - 3.9e-39 132.6 0.2 8.2e-39 131.6 0.1 1.6 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.6 ERZ95229.1 - 3.6e-05 23.1 0.0 6.4e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 ERZ95229.1 - 0.0041 16.9 4.5 0.017 14.9 3.1 2.1 1 1 0 1 1 1 1 Amidohydrolase cobW PF02492.14 ERZ95230.1 - 4.3e-34 117.5 0.0 5.2e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 ERZ95230.1 - 0.00032 19.5 0.8 0.015 14.1 0.6 2.1 1 1 0 1 1 1 1 ArgK protein AAA_18 PF13238.1 ERZ95230.1 - 0.0032 17.7 0.0 0.0058 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 ERZ95230.1 - 0.0037 17.1 0.0 0.009 15.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase CbiA PF01656.18 ERZ95230.1 - 0.0064 15.9 0.0 0.0089 15.4 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Pox_A32 PF04665.7 ERZ95230.1 - 0.017 14.4 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_17 PF13207.1 ERZ95230.1 - 0.026 15.3 0.1 0.047 14.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 ERZ95230.1 - 0.026 14.2 0.0 0.047 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ERZ95230.1 - 0.045 12.4 0.0 0.066 11.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus IstB_IS21 PF01695.12 ERZ95230.1 - 0.057 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.22 ERZ95230.1 - 0.093 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 ERZ95230.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 ERZ95230.1 - 0.13 11.1 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain Arch_ATPase PF01637.13 ERZ95230.1 - 0.14 11.7 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 ERZ95230.1 - 0.16 12.2 0.0 0.21 11.8 0.0 1.3 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 ERZ95230.1 - 0.3 10.7 1.1 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2360 PF10152.4 ERZ95231.1 - 0.063 13.5 0.1 0.079 13.2 0.0 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF2782 PF11191.3 ERZ95231.1 - 0.12 12.3 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2782) Isochorismatase PF00857.15 ERZ95232.1 - 7e-38 130.2 0.0 8.9e-38 129.9 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF2761 PF10959.3 ERZ95232.1 - 0.03 13.9 0.1 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2761) Hjc PF01870.13 ERZ95233.1 - 0.023 14.2 2.1 0.026 14.1 0.1 2.1 2 0 0 2 2 2 0 Archaeal holliday junction resolvase (hjc) DnaA_N PF11638.3 ERZ95233.1 - 0.18 11.3 1.5 0.49 10.0 1.1 1.8 1 0 0 1 1 1 0 DnaA N-terminal domain DUF4207 PF13904.1 ERZ95233.1 - 7.6 5.8 11.2 12 5.1 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) FliJ PF02050.11 ERZ95233.1 - 8.7 6.4 14.8 3.9 7.5 4.8 2.6 2 1 0 2 2 2 0 Flagellar FliJ protein Mak16 PF04874.9 ERZ95235.1 - 0.079 13.0 0.7 0.079 13.0 0.5 1.6 2 0 0 2 2 2 0 Mak16 protein C-terminal region RabGAP-TBC PF00566.13 ERZ95236.1 - 6e-49 166.4 0.6 1e-48 165.6 0.4 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.20 ERZ95236.1 - 8.2e-29 100.5 0.0 1.2e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95236.1 - 9.1e-16 57.6 0.0 1.6e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.15 ERZ95236.1 - 8.1e-10 39.0 0.0 1.6e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kinase-like PF14531.1 ERZ95236.1 - 1.4e-05 24.2 0.0 2.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF2795 PF11387.3 ERZ95236.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) DUF3542 PF12061.3 ERZ95238.1 - 0.00014 20.9 1.0 0.00014 20.9 0.7 2.3 2 2 1 3 3 3 1 Protein of unknown function (DUF3542) FliJ PF02050.11 ERZ95238.1 - 0.026 14.5 45.9 0.27 11.3 2.8 4.7 1 1 4 5 5 5 0 Flagellar FliJ protein Filament PF00038.16 ERZ95238.1 - 0.099 12.0 45.8 5.3 6.4 26.6 3.2 1 1 2 3 3 3 0 Intermediate filament protein HrpB7 PF09486.5 ERZ95238.1 - 0.12 12.3 29.6 0.9 9.4 5.1 4.2 1 1 3 4 4 4 0 Bacterial type III secretion protein (HrpB7) Tropomyosin PF00261.15 ERZ95238.1 - 0.16 11.0 48.8 0.014 14.5 21.8 2.2 2 0 0 2 2 2 0 Tropomyosin AAA_13 PF13166.1 ERZ95238.1 - 0.23 9.8 46.6 0.8 8.0 15.9 2.1 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.6 ERZ95238.1 - 0.24 10.0 49.7 0.05 12.2 13.3 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein Rotamase PF00639.16 ERZ95238.1 - 0.46 11.2 0.1 0.46 11.2 0.1 4.2 1 1 2 4 4 4 0 PPIC-type PPIASE domain IncA PF04156.9 ERZ95238.1 - 0.48 9.9 47.7 1.3 8.5 1.3 4.2 1 1 3 4 4 4 0 IncA protein WEMBL PF05701.6 ERZ95238.1 - 0.49 8.7 53.9 0.65 8.3 34.1 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 ERZ95238.1 - 0.66 9.0 15.7 0.29 10.2 3.7 2.6 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 ERZ95238.1 - 0.72 7.1 45.3 0.1 9.9 14.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF812 PF05667.6 ERZ95238.1 - 1 7.7 46.1 4.6 5.6 14.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) ADIP PF11559.3 ERZ95238.1 - 1.5 8.7 51.4 6.3 6.6 1.8 4.5 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding DUF940 PF06082.6 ERZ95238.1 - 1.9 6.9 14.9 2.5 6.5 10.4 1.1 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) KxDL PF10241.4 ERZ95238.1 - 3.3 7.6 19.6 0.78 9.6 2.1 4.2 3 2 2 5 5 5 0 Uncharacterized conserved protein Mnd1 PF03962.10 ERZ95238.1 - 3.7 7.1 48.6 0.55 9.8 2.5 3.6 1 1 2 3 3 2 0 Mnd1 family FlxA PF14282.1 ERZ95238.1 - 4.1 7.4 37.9 0.77 9.7 6.9 5.0 1 1 4 5 5 5 0 FlxA-like protein CorA PF01544.13 ERZ95238.1 - 4.8 6.1 23.5 3.7 6.4 6.4 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ApoO PF09769.4 ERZ95238.1 - 6.3 6.4 18.1 0.65 9.6 2.8 3.5 1 1 1 3 3 3 0 Apolipoprotein O NPV_P10 PF05531.7 ERZ95238.1 - 6.3 7.1 23.1 3.4 7.9 0.1 5.1 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein PhaC_N PF07167.8 ERZ95238.1 - 7.1 6.0 8.2 1.3 8.3 1.8 2.4 3 0 0 3 3 3 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus ATG16 PF08614.6 ERZ95238.1 - 7.5 6.3 45.9 30 4.3 4.9 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Baculo_PEP_C PF04513.7 ERZ95238.1 - 9 6.1 19.2 1.8 8.4 5.0 3.8 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4286 PF14114.1 ERZ95239.1 - 5.9e-11 42.4 0.3 8.2e-11 42.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4286) WD40 PF00400.27 ERZ95240.1 - 3.4e-40 134.5 13.7 1.2e-09 37.6 0.1 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ERZ95240.1 - 0.0016 17.2 3.5 0.017 13.8 0.9 2.6 2 1 0 2 2 2 1 Nup133 N terminal like Nha1_C PF08619.5 ERZ95240.1 - 0.021 14.1 10.3 0.032 13.5 7.1 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Nup160 PF11715.3 ERZ95240.1 - 0.025 12.7 0.1 0.26 9.3 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Vfa1 PF08432.5 ERZ95240.1 - 0.1 12.5 8.2 0.18 11.7 5.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 HMG_box PF00505.14 ERZ95241.1 - 0.0051 17.0 0.5 0.017 15.3 0.0 2.1 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box PF00505.14 ERZ95242.1 - 0.0059 16.8 0.0 0.017 15.3 0.0 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box AAA PF00004.24 ERZ95243.1 - 1.5e-14 54.3 0.0 3.9e-14 52.9 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95243.1 - 1.7e-06 28.1 0.0 2.6e-06 27.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 ERZ95243.1 - 6.2e-06 26.3 0.3 1.8e-05 24.8 0.0 1.8 1 1 1 2 2 2 1 RNA helicase RuvB_N PF05496.7 ERZ95243.1 - 3e-05 23.1 0.0 3.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ERZ95243.1 - 4.5e-05 24.2 0.0 7.6e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ERZ95243.1 - 5.3e-05 22.9 0.0 0.0005 19.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 ERZ95243.1 - 0.0004 19.3 0.0 0.00085 18.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_29 PF13555.1 ERZ95243.1 - 0.00051 19.5 0.0 0.0044 16.5 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain TIP49 PF06068.8 ERZ95243.1 - 0.001 17.8 0.0 0.0016 17.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 ERZ95243.1 - 0.0013 18.4 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_24 PF13479.1 ERZ95243.1 - 0.0022 17.6 0.4 0.01 15.4 0.1 1.9 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ERZ95243.1 - 0.0032 17.2 0.1 0.0055 16.4 0.1 1.4 1 1 0 1 1 1 1 Archaeal ATPase AAA_18 PF13238.1 ERZ95243.1 - 0.0043 17.3 0.1 0.0083 16.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 ERZ95243.1 - 0.0049 16.0 0.1 0.011 14.8 0.0 1.5 2 0 0 2 2 2 1 KaiC AAA_22 PF13401.1 ERZ95243.1 - 0.0053 16.9 0.4 0.011 15.8 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.1 ERZ95243.1 - 0.0068 16.7 0.7 0.012 15.9 0.4 1.5 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 ERZ95243.1 - 0.008 15.1 0.0 0.0087 15.0 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Bac_DnaA PF00308.13 ERZ95243.1 - 0.0085 15.7 0.1 0.019 14.6 0.0 1.6 1 1 0 2 2 2 1 Bacterial dnaA protein AAA_14 PF13173.1 ERZ95243.1 - 0.011 15.6 0.1 0.016 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ERZ95243.1 - 0.017 15.0 0.2 0.029 14.3 0.1 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase IstB_IS21 PF01695.12 ERZ95243.1 - 0.022 14.1 0.1 0.057 12.8 0.1 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 ERZ95243.1 - 0.023 13.7 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.4 ERZ95243.1 - 0.03 13.2 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Miro PF08477.8 ERZ95243.1 - 0.033 14.6 0.0 0.048 14.1 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein NACHT PF05729.7 ERZ95243.1 - 0.045 13.4 0.1 0.11 12.1 0.0 1.8 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 ERZ95243.1 - 0.052 13.8 0.1 0.085 13.1 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 ERZ95243.1 - 0.06 12.7 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 ERZ95243.1 - 0.073 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.1 ERZ95243.1 - 0.09 12.3 0.0 0.13 11.8 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ERZ95243.1 - 0.099 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ERZ95243.1 - 0.11 11.4 0.1 0.22 10.3 0.0 1.4 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 ERZ95243.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ERZ95243.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MCM PF00493.18 ERZ95243.1 - 0.12 11.1 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 MCM2/3/5 family DUF258 PF03193.11 ERZ95243.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF4413 PF14372.1 ERZ95244.1 - 0.23 11.4 1.7 0.95 9.4 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4413) Pkinase PF00069.20 ERZ95245.1 - 8.5e-20 70.9 0.2 2e-19 69.7 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95245.1 - 8.6e-18 64.3 0.1 1.7e-13 50.2 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase MACPF PF01823.14 ERZ95246.1 - 1.6e-06 27.9 0.8 9.2e-06 25.4 0.5 2.1 1 1 0 1 1 1 1 MAC/Perforin domain GBP PF02263.14 ERZ95247.1 - 9.4e-38 129.7 0.2 1.4e-30 106.1 0.0 2.6 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain zf-NPL4 PF05020.10 ERZ95247.1 - 0.052 13.1 3.3 8.2 6.0 0.1 3.1 3 0 0 3 3 3 0 NPL4 family, putative zinc binding region Dynamin_N PF00350.18 ERZ95247.1 - 0.61 9.8 0.0 0.61 9.8 0.0 3.3 5 0 0 5 5 5 0 Dynamin family GBP PF02263.14 ERZ95248.1 - 1.7e-34 119.0 0.0 2.5e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 ERZ95248.1 - 0.053 13.3 0.1 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 Dynamin family MFS_1 PF07690.11 ERZ95249.1 - 9.7e-13 47.5 29.1 3e-10 39.3 7.9 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sec62 PF03839.11 ERZ95249.1 - 1.1 8.6 2.9 5.6 6.3 0.1 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 RseC_MucC PF04246.7 ERZ95249.1 - 3 7.4 4.7 2.1 7.9 0.9 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC PGK PF00162.14 ERZ95250.1 - 9.6e-152 504.9 0.1 1.1e-151 504.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Peripla_BP_4 PF13407.1 ERZ95250.1 - 0.036 13.4 0.5 0.071 12.4 0.4 1.4 1 0 0 1 1 1 0 Periplasmic binding protein domain RNA_pol_Rpb1_5 PF04998.12 ERZ95251.1 - 0.031 13.5 1.2 0.044 13.0 0.9 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Glyco_hydro_67C PF07477.7 ERZ95251.1 - 0.035 13.5 0.6 0.066 12.6 0.1 1.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 C-terminus Glucosaminidase PF01832.15 ERZ95251.1 - 0.059 13.4 0.1 0.096 12.8 0.1 1.3 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase DUF3139 PF11337.3 ERZ95251.1 - 1.1 9.6 4.4 0.42 10.9 0.9 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) RabGAP-TBC PF00566.13 ERZ95252.1 - 1.9e-47 161.5 3.5 3.9e-47 160.4 2.4 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4413 PF14372.1 ERZ95253.1 - 6.9e-05 22.7 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Acetyltransf_1 PF00583.19 ERZ95253.1 - 0.007 16.3 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 ERZ95253.1 - 0.056 13.5 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_35 PF14516.1 ERZ95255.1 - 1.1e-10 40.7 0.0 1.8e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA PF00004.24 ERZ95255.1 - 0.028 14.6 0.0 0.068 13.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_35 PF14516.1 ERZ95256.1 - 1.5e-08 33.6 0.0 2.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA PF00004.24 ERZ95256.1 - 0.12 12.5 0.0 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Kinesin PF00225.18 ERZ95257.1 - 6.8e-95 317.5 0.1 6.8e-95 317.5 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain KxDL PF10241.4 ERZ95257.1 - 0.023 14.5 0.8 0.13 12.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein MreB_Mbl PF06723.8 ERZ95259.1 - 2.5e-06 26.3 0.0 0.022 13.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DUF3450 PF11932.3 ERZ95260.1 - 0.013 14.7 2.0 0.013 14.7 1.4 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) NEP PF10167.4 ERZ95260.1 - 0.37 10.4 7.6 0.38 10.4 0.2 3.1 2 1 1 3 3 3 0 Uncharacterised conserved protein Phage_lysis PF03245.8 ERZ95260.1 - 1.9 8.5 6.5 95 2.9 4.5 3.2 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein LMBR1 PF04791.11 ERZ95260.1 - 8.4 4.8 7.9 9.2 4.7 5.3 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein PPP4R2 PF09184.6 ERZ95262.1 - 0.13 11.7 0.2 0.13 11.7 0.1 3.4 3 1 0 3 3 3 0 PPP4R2 SR-25 PF10500.4 ERZ95262.1 - 0.2 11.0 73.5 0.32 10.4 15.6 3.3 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein BRCT_assoc PF12820.2 ERZ95264.1 - 0.027 14.2 1.0 0.036 13.8 0.6 1.4 1 1 0 1 1 1 0 Serine-rich domain associated with BRCT DUF3582 PF12122.3 ERZ95264.1 - 0.035 14.1 0.4 0.06 13.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3582) Laminin_G_3 PF13385.1 ERZ95268.1 - 0.077 13.2 1.3 0.11 12.7 0.9 1.3 1 1 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily tRNA_U5-meth_tr PF05958.6 ERZ95269.1 - 0.07 11.8 0.1 0.091 11.4 0.0 1.0 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase AAA_29 PF13555.1 ERZ95270.1 - 0.025 14.0 0.0 0.054 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_35 PF14516.1 ERZ95271.1 - 2.1e-15 56.1 0.0 1.1e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 AAA-like domain AAA_14 PF13173.1 ERZ95271.1 - 3e-05 23.9 0.1 0.00036 20.4 0.0 3.0 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ERZ95271.1 - 0.0003 20.5 0.0 0.00092 18.9 0.0 1.8 1 0 0 1 1 1 1 Archaeal ATPase Zot PF05707.7 ERZ95271.1 - 0.0011 18.4 0.0 0.0067 15.9 0.0 2.1 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA PF00004.24 ERZ95271.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma70_r2 PF04542.9 ERZ95271.1 - 0.023 14.2 0.1 1.1 8.8 0.0 3.0 3 0 0 3 3 3 0 Sigma-70 region 2 KTI12 PF08433.5 ERZ95271.1 - 0.062 12.4 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_29 PF13555.1 ERZ95271.1 - 0.11 12.0 0.2 0.44 10.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.1 ERZ95271.1 - 0.14 12.1 0.0 0.61 10.0 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_35 PF14516.1 ERZ95272.1 - 6.3e-15 54.6 0.1 2.2e-14 52.8 0.0 1.7 2 0 0 2 2 2 1 AAA-like domain AAA_14 PF13173.1 ERZ95272.1 - 0.00012 21.9 0.1 0.00099 19.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ERZ95272.1 - 0.00085 19.0 0.1 0.0023 17.6 0.1 1.8 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ERZ95272.1 - 0.0024 18.0 0.0 0.0057 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain PDDEXK_3 PF13366.1 ERZ95272.1 - 0.015 15.3 0.0 0.04 13.9 0.0 1.7 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily AAA_16 PF13191.1 ERZ95272.1 - 0.02 14.8 0.1 0.1 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 ERZ95272.1 - 0.032 14.4 0.0 0.071 13.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ERZ95272.1 - 0.077 12.5 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Big_1 PF02369.11 ERZ95273.1 - 0.034 14.0 0.8 0.038 13.8 0.6 1.1 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) KilA-N PF04383.8 ERZ95274.1 - 0.0066 16.0 1.1 2.4 7.8 0.2 2.6 2 0 0 2 2 2 2 KilA-N domain Pkinase_Tyr PF07714.12 ERZ95275.1 - 2.3e-50 171.0 0.0 3.6e-50 170.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95275.1 - 3.7e-46 157.4 0.0 6.1e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ95275.1 - 5.5e-06 25.5 0.0 9.6e-06 24.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95275.1 - 0.0011 18.7 0.2 0.0058 16.3 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ95275.1 - 0.0014 18.0 0.2 0.0032 16.8 0.1 1.5 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ERZ95275.1 - 0.018 14.2 0.2 0.031 13.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) PRP3 PF08572.5 ERZ95276.1 - 4.5e-68 228.9 7.3 4.5e-68 228.9 5.1 1.6 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 ERZ95276.1 - 3.6e-36 123.6 1.5 1.1e-35 122.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) YfcL PF08891.6 ERZ95276.1 - 0.078 12.9 1.3 0.38 10.7 0.4 2.3 2 0 0 2 2 2 0 YfcL protein TusA PF01206.12 ERZ95276.1 - 0.18 11.4 1.0 1.8 8.2 0.3 2.4 2 0 0 2 2 2 0 Sulfurtransferase TusA DUF2361 PF10153.4 ERZ95277.1 - 3.8e-18 65.7 9.7 3.8e-18 65.7 6.7 1.3 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2361) DUF1307 PF06998.6 ERZ95277.1 - 0.071 13.1 3.0 0.08 12.9 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1307) DUF4391 PF14335.1 ERZ95277.1 - 0.31 10.3 7.5 0.42 9.9 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) vMSA PF00695.14 ERZ95279.1 - 0.066 12.4 0.0 0.069 12.3 0.0 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Vac_Fusion PF02346.11 ERZ95281.1 - 0.00039 19.7 0.5 0.00039 19.7 0.3 3.0 3 0 0 3 3 3 1 Chordopoxvirus fusion protein ADIP PF11559.3 ERZ95281.1 - 0.014 15.3 8.3 0.014 15.3 5.8 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF641 PF04859.7 ERZ95281.1 - 0.073 12.8 26.7 0.029 14.1 2.8 3.3 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF2420 PF10336.4 ERZ95281.1 - 0.26 10.8 12.1 0.042 13.4 3.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2420) DUF4279 PF14106.1 ERZ95281.1 - 1.2 9.0 10.9 0.079 12.8 1.8 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4279) DUF745 PF05335.8 ERZ95281.1 - 1.9 7.9 18.4 1.8 8.0 8.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Fib_alpha PF08702.5 ERZ95281.1 - 2.2 8.3 26.2 0.15 12.2 5.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.1 ERZ95281.1 - 2.3 6.5 33.3 0.057 11.8 6.3 2.1 1 1 1 2 2 2 0 AAA domain Allexi_40kDa PF05549.6 ERZ95281.1 - 3.4 6.9 17.6 1.3 8.2 2.5 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein ENT PF03735.9 ERZ95281.1 - 4.2 7.1 16.4 0.1 12.3 2.3 3.3 3 1 0 3 3 3 0 ENT domain BTB PF00651.26 ERZ95282.1 - 1.1e-18 67.2 0.0 2e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ95282.1 - 3.6e-12 46.0 7.3 1.3e-07 31.3 0.2 4.5 3 1 2 5 5 5 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ95282.1 - 0.044 12.9 0.2 0.065 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Cupin_4 PF08007.7 ERZ95282.1 - 0.074 12.2 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Cupin superfamily protein DUF3887 PF13026.1 ERZ95285.1 - 0.2 11.9 5.9 0.37 11.1 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) DNA_pol_phi PF04931.8 ERZ95285.1 - 3.9 5.1 11.8 5.5 4.6 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Oxysterol_BP PF01237.13 ERZ95286.1 - 2.3e-87 292.7 0.0 3e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein CENP-O PF09496.5 ERZ95286.1 - 0.11 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component IBN_N PF03810.14 ERZ95287.1 - 0.031 14.1 0.0 0.13 12.1 0.0 2.2 1 0 0 1 1 1 0 Importin-beta N-terminal domain RabGAP-TBC PF00566.13 ERZ95288.1 - 8.3e-46 156.1 1.9 3.3e-45 154.1 0.3 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Porin_3 PF01459.17 ERZ95289.1 - 2.3e-67 227.1 0.3 2.7e-67 226.9 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin UQ_con PF00179.21 ERZ95291.1 - 1.9e-07 30.6 0.4 2.6e-07 30.1 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pkinase_Tyr PF07714.12 ERZ95292.1 - 4.1e-44 150.5 0.6 1.2e-35 122.9 0.4 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95292.1 - 3e-39 134.7 2.6 1.8e-33 115.8 2.1 2.0 1 1 1 2 2 2 2 Protein kinase domain YrbL-PhoP_reg PF10707.4 ERZ95292.1 - 0.00075 18.8 0.2 0.0011 18.3 0.2 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ERZ95292.1 - 0.0024 17.6 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ95292.1 - 0.0073 15.6 0.5 0.013 14.8 0.3 1.4 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ95292.1 - 0.028 13.4 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.11 ERZ95292.1 - 0.062 13.2 0.0 0.18 11.7 0.0 1.9 1 1 0 1 1 1 0 ABC1 family F-box-like PF12937.2 ERZ95293.1 - 0.00036 20.1 4.3 0.00036 20.1 3.0 2.6 2 0 0 2 2 2 1 F-box-like LRR_7 PF13504.1 ERZ95293.1 - 0.64 10.4 10.6 61 4.5 0.2 5.9 6 0 0 6 6 6 0 Leucine rich repeat LRR_4 PF12799.2 ERZ95293.1 - 9 6.0 24.0 0.48 10.1 0.3 5.7 4 2 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_4 PF12799.2 ERZ95294.1 - 2.1e-08 33.5 11.8 0.00018 21.0 0.1 4.7 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ95294.1 - 2.3e-05 24.0 12.2 0.15 11.7 0.1 5.1 4 1 0 4 4 4 2 Leucine rich repeat F-box-like PF12937.2 ERZ95294.1 - 7.7e-05 22.3 0.8 0.00027 20.6 0.1 2.4 3 0 0 3 3 3 1 F-box-like LRR_6 PF13516.1 ERZ95294.1 - 0.00032 20.4 17.8 0.0052 16.7 0.2 7.3 8 0 0 8 8 8 1 Leucine Rich repeat LRR_7 PF13504.1 ERZ95294.1 - 0.013 15.6 7.2 0.59 10.5 0.2 5.8 7 0 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 ERZ95294.1 - 0.11 12.6 0.1 0.11 12.6 0.1 6.8 6 2 0 6 6 6 0 Leucine Rich Repeat SH3_1 PF00018.23 ERZ95295.1 - 5.9e-15 54.3 0.2 7.1e-15 54.1 0.1 1.1 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ERZ95295.1 - 1.7e-12 46.6 0.2 2.1e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 ERZ95295.1 - 1.6e-09 37.1 0.2 2.6e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain TPX2_importin PF12214.3 ERZ95298.1 - 0.00015 21.8 5.8 0.027 14.5 2.6 2.1 1 1 1 2 2 2 2 Cell cycle regulated microtubule associated protein P53 PF00870.13 ERZ95299.1 - 0.041 13.4 0.0 0.047 13.2 0.0 1.1 1 0 0 1 1 1 0 P53 DNA-binding domain BTB PF00651.26 ERZ95300.1 - 2.9e-18 65.8 0.0 3.7e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain HTH_32 PF13565.1 ERZ95300.1 - 0.13 13.0 0.0 24 5.7 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain MFS_1 PF07690.11 ERZ95302.1 - 2e-48 164.9 32.8 2e-48 164.9 22.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ERZ95302.1 - 2.2e-12 46.3 11.7 2.2e-12 46.3 8.1 3.3 3 1 0 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.8 ERZ95302.1 - 0.00013 20.2 0.7 0.00013 20.2 0.5 1.6 2 0 0 2 2 2 1 Transmembrane secretion effector Fzo_mitofusin PF04799.8 ERZ95302.1 - 0.7 9.2 3.9 2.2 7.6 0.5 2.4 2 0 0 2 2 2 0 fzo-like conserved region Peptidase_C39_2 PF13529.1 ERZ95304.1 - 0.12 12.7 0.4 0.14 12.5 0.3 1.0 1 0 0 1 1 1 0 Peptidase_C39 like family MAT1 PF06391.8 ERZ95305.1 - 0.026 14.1 1.8 0.032 13.8 1.3 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 MitMem_reg PF13012.1 ERZ95305.1 - 0.028 14.5 1.9 0.046 13.8 1.3 1.5 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function VLPT PF07122.6 ERZ95305.1 - 0.081 12.6 4.9 0.081 12.6 3.4 2.2 2 0 0 2 2 2 0 Variable length PCR target protein (VLPT) EAP30 PF04157.11 ERZ95306.1 - 7.7e-43 146.2 3.3 1.1e-42 145.7 2.3 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 ERZ95306.1 - 2.1e-26 91.5 0.0 3.9e-26 90.6 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-RanBP PF00641.13 ERZ95306.1 - 0.00013 21.0 13.9 0.00066 18.7 3.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DZR PF12773.2 ERZ95306.1 - 0.0026 17.5 7.3 0.05 13.4 0.3 2.3 1 1 1 2 2 2 2 Double zinc ribbon WWbp PF10349.4 ERZ95306.1 - 0.02 15.7 0.0 0.058 14.2 0.0 1.8 1 0 0 1 1 1 0 WW-domain ligand protein MarR PF01047.17 ERZ95306.1 - 0.039 13.6 0.1 0.097 12.3 0.1 1.6 1 0 0 1 1 1 0 MarR family GCC2_GCC3 PF07699.8 ERZ95306.1 - 0.039 13.5 5.8 1.4 8.6 1.1 2.5 2 0 0 2 2 2 0 GCC2 and GCC3 GRAM PF02893.15 ERZ95306.1 - 0.049 13.1 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 GRAM domain HTH_24 PF13412.1 ERZ95306.1 - 0.095 12.1 0.2 0.22 10.9 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding GldM_N PF12081.3 ERZ95306.1 - 0.13 11.7 4.0 1.4 8.3 2.2 2.2 2 0 0 2 2 2 0 GldM N-terminal domain zf-ribbon_3 PF13248.1 ERZ95306.1 - 1.1 8.5 5.5 3.5 6.9 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-Sec23_Sec24 PF04810.10 ERZ95306.1 - 1.3 8.6 13.0 0.67 9.5 1.0 3.1 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger NCD3G PF07562.9 ERZ95306.1 - 5.5 6.7 9.3 9.7 5.9 0.5 2.4 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Pkinase_Tyr PF07714.12 ERZ95307.1 - 7.5e-80 267.7 0.1 6.8e-59 199.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95307.1 - 7.1e-74 248.2 2.4 3e-51 174.0 0.3 2.3 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ERZ95307.1 - 9.1e-05 21.8 0.5 0.07 12.4 0.2 2.9 2 1 0 2 2 2 2 RIO1 family AIG1 PF04548.11 ERZ95307.1 - 0.00018 20.6 4.3 0.0011 18.1 3.0 2.3 1 1 0 1 1 1 1 AIG1 family Kdo PF06293.9 ERZ95307.1 - 0.011 14.7 1.3 0.18 10.8 0.1 2.8 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_17 PF13207.1 ERZ95307.1 - 0.013 16.3 0.1 0.013 16.3 0.1 3.4 2 1 1 3 3 3 0 AAA domain MMR_HSR1 PF01926.18 ERZ95307.1 - 0.019 14.9 2.1 0.031 14.2 0.4 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase ABC1 PF03109.11 ERZ95307.1 - 0.06 13.3 0.0 0.96 9.4 0.0 2.4 2 0 0 2 2 2 0 ABC1 family T2SE PF00437.15 ERZ95307.1 - 0.068 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein APH PF01636.18 ERZ95307.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FtsK_SpoIIIE PF01580.13 ERZ95307.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF4108 PF13390.1 ERZ95308.1 - 0.021 14.5 0.5 0.049 13.3 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4108) Sel1 PF08238.7 ERZ95312.1 - 5.2e-66 217.6 13.7 7.4e-10 39.1 0.0 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ERZ95312.1 - 6.4e-06 26.2 5.8 0.68 10.5 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat NifW PF03206.9 ERZ95312.1 - 0.011 15.8 0.4 16 5.6 0.1 4.2 2 2 3 5 5 5 0 Nitrogen fixation protein NifW TPR_11 PF13414.1 ERZ95312.1 - 0.13 11.9 27.3 1.2 8.8 0.5 6.8 1 1 7 8 8 8 0 TPR repeat IR1-M PF12185.3 ERZ95312.1 - 2.4 7.9 6.5 88 2.9 0.0 4.5 5 0 0 5 5 5 0 Nup358/RanBP2 E3 ligase domain HSP20 PF00011.16 ERZ95313.1 - 4.2e-09 36.1 0.0 5.1e-09 35.9 0.0 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family AMP-binding PF00501.23 ERZ95314.1 - 2e-91 306.5 0.0 2.3e-91 306.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ERZ95314.1 - 1.3e-16 61.3 0.1 4.7e-16 59.4 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain LpxD PF04613.9 ERZ95314.1 - 0.011 15.2 0.1 0.034 13.6 0.0 1.8 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD DUF2874 PF11396.3 ERZ95314.1 - 0.15 12.0 1.4 2 8.4 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) RNA_lig_T4_1 PF09511.5 ERZ95315.1 - 1.9e-73 246.6 1.1 1.9e-73 246.6 0.8 2.2 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.6 ERZ95315.1 - 1.9e-41 141.7 0.9 6.2e-41 140.0 0.7 2.0 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 ERZ95315.1 - 5.6e-24 84.7 8.6 7.1e-23 81.1 6.0 2.7 1 1 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain KTI12 PF08433.5 ERZ95315.1 - 0.00058 19.1 0.3 0.0013 17.9 0.2 1.7 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 ERZ95315.1 - 0.0031 18.3 0.5 0.037 14.8 0.0 3.0 3 2 0 3 3 3 1 AAA domain AAA_33 PF13671.1 ERZ95315.1 - 0.017 14.9 0.0 0.046 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ERZ95315.1 - 5.9 7.1 9.2 0.71 10.1 1.5 3.1 3 2 0 3 3 3 0 ABC transporter ABC_tran PF00005.22 ERZ95317.1 - 1.5e-14 54.4 0.0 2.7e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ERZ95317.1 - 3.8e-07 30.3 1.2 0.016 15.2 0.0 2.8 2 1 1 3 3 3 2 AAA domain SMC_N PF02463.14 ERZ95317.1 - 1.9e-05 24.0 0.1 0.00028 20.2 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.24 ERZ95317.1 - 0.0036 17.5 0.0 0.01 16.0 0.0 1.8 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95317.1 - 0.012 15.6 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.1 ERZ95317.1 - 0.024 14.5 0.0 0.18 11.7 0.0 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.1 ERZ95317.1 - 0.032 13.2 0.1 1.3 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_13 PF13166.1 ERZ95317.1 - 0.041 12.3 0.3 0.12 10.8 0.0 1.9 1 1 0 2 2 2 0 AAA domain NACHT PF05729.7 ERZ95317.1 - 0.048 13.3 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 ERZ95317.1 - 0.073 12.7 0.1 0.37 10.5 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 ERZ95317.1 - 0.073 13.2 0.0 0.53 10.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.9 ERZ95317.1 - 0.097 12.3 0.0 0.39 10.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Acetyltransf_3 PF13302.1 ERZ95318.1 - 1.4e-20 73.9 0.0 1.8e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ERZ95318.1 - 1.4e-12 47.8 1.8 3.2e-12 46.6 1.3 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ERZ95318.1 - 3.9e-08 33.1 0.0 6.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 ERZ95318.1 - 1.1e-05 25.3 0.0 1.5e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ERZ95318.1 - 0.00056 20.0 0.3 0.00094 19.3 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AMP-binding PF00501.23 ERZ95319.1 - 2e-90 303.1 0.0 2.4e-90 302.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ERZ95319.1 - 9.6e-16 58.5 0.0 3.1e-15 56.8 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Arch_ATPase PF01637.13 ERZ95320.1 - 6.4e-18 65.3 0.2 9.4e-18 64.7 0.1 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ERZ95320.1 - 4.5e-07 30.0 0.0 2.5e-06 27.6 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 ERZ95320.1 - 4.5e-06 26.9 0.0 5.9e-05 23.2 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ95320.1 - 6.1e-06 26.3 0.0 9.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ERZ95320.1 - 1.6e-05 24.7 1.3 0.075 12.9 0.0 2.8 1 1 1 2 2 2 2 AAA domain RNA12 PF10443.4 ERZ95320.1 - 0.00021 19.9 0.0 0.0072 14.8 0.0 2.2 2 0 0 2 2 2 1 RNA12 protein Adeno_IVa2 PF02456.10 ERZ95320.1 - 0.007 15.0 0.1 0.19 10.3 0.0 2.4 2 0 0 2 2 2 1 Adenovirus IVa2 protein NACHT PF05729.7 ERZ95320.1 - 0.011 15.4 0.3 0.11 12.1 0.2 2.2 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.1 ERZ95320.1 - 0.015 14.8 0.0 0.035 13.6 0.0 1.6 1 1 0 2 2 2 0 AAA domain Miro PF08477.8 ERZ95320.1 - 0.018 15.5 0.0 0.06 13.8 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Archease PF01951.11 ERZ95320.1 - 0.021 14.7 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) Zeta_toxin PF06414.7 ERZ95320.1 - 0.042 12.9 0.0 0.09 11.8 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.1 ERZ95320.1 - 0.051 13.4 0.0 0.15 11.9 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.1 ERZ95320.1 - 0.074 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ERZ95320.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain DEAD PF00270.24 ERZ95321.1 - 5.1e-34 117.1 0.0 8.9e-34 116.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ95321.1 - 6.5e-22 77.1 0.0 1.8e-21 75.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ERZ95321.1 - 5.2e-07 29.6 0.0 1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ERZ95321.1 - 0.0016 18.1 0.0 0.004 16.8 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain FBA_3 PF08268.7 ERZ95321.1 - 0.0075 15.9 0.1 1 9.0 0.0 2.3 2 0 0 2 2 2 1 F-box associated domain CMS1 PF14617.1 ERZ95321.1 - 0.049 12.7 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 ERZ95321.1 - 0.077 11.3 2.5 0.64 8.3 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1253) Helicase_RecD PF05127.9 ERZ95321.1 - 0.078 12.6 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 Helicase MRG PF05712.8 ERZ95322.1 - 8.3e-53 178.1 7.7 1.4e-52 177.4 5.4 1.3 1 0 0 1 1 1 1 MRG GATA PF00320.22 ERZ95322.1 - 6.1e-13 47.8 4.4 1.1e-12 47.0 3.1 1.4 1 0 0 1 1 1 1 GATA zinc finger Tudor-knot PF11717.3 ERZ95322.1 - 3.3e-11 42.7 0.3 7.8e-11 41.5 0.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 ERZ95322.1 - 0.0036 16.9 2.1 0.011 15.4 1.5 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain OTT_1508_deam PF14441.1 ERZ95322.1 - 0.83 9.4 5.9 9.7 5.9 0.3 3.0 3 1 0 3 3 3 0 OTT_1508-like deaminase CK_II_beta PF01214.13 ERZ95323.1 - 7.3e-79 263.5 0.0 8.9e-79 263.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit TerD PF02342.13 ERZ95324.1 - 2.7e-12 46.3 0.0 4.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ95324.1 - 2.9e-10 39.3 0.9 8.3e-10 37.9 0.6 1.8 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ95324.1 - 0.0014 18.2 0.2 0.0032 17.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Papo_T_antigen PF02380.10 ERZ95324.1 - 2 8.4 6.2 1.1 9.2 2.9 1.7 2 0 0 2 2 2 0 T-antigen specific domain TerD PF02342.13 ERZ95325.1 - 2.2e-14 53.2 0.0 4.3e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ95325.1 - 2.7e-07 29.8 3.0 2e-06 27.0 2.1 2.4 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ95325.1 - 0.0051 16.4 1.1 0.017 14.8 0.8 1.9 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ95325.1 - 0.018 15.2 0.6 0.039 14.1 0.4 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain zf-Apc11 PF12861.2 ERZ95325.1 - 0.025 14.3 2.6 0.057 13.2 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 ERZ95325.1 - 0.04 13.6 8.0 0.075 12.7 5.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ95325.1 - 0.041 13.5 9.1 0.078 12.7 6.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ERZ95325.1 - 0.088 12.8 7.1 0.2 11.6 4.9 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ERZ95325.1 - 0.11 12.3 7.5 0.2 11.5 5.2 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.20 ERZ95325.1 - 0.22 11.2 9.8 0.49 10.1 6.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.2 ERZ95325.1 - 0.65 9.8 5.1 1.6 8.6 3.6 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.1 ERZ95325.1 - 1.6 8.7 7.1 3.2 7.6 4.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Mito_carr PF00153.22 ERZ95326.1 - 6.9e-63 208.3 0.1 9.7e-21 73.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Romo1 PF10247.4 ERZ95327.1 - 2.3e-20 72.5 4.6 3e-20 72.1 3.2 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.14 ERZ95327.1 - 0.018 15.0 0.2 0.024 14.6 0.2 1.3 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family COX16 PF14138.1 ERZ95329.1 - 3.3e-25 88.0 0.3 4e-25 87.7 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Vps5 PF09325.5 ERZ95329.1 - 0.048 12.9 1.2 0.058 12.6 0.8 1.1 1 0 0 1 1 1 0 Vps5 C terminal like B12D PF06522.6 ERZ95329.1 - 0.076 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SAS4 PF15460.1 ERZ95329.1 - 0.088 12.6 6.0 0.12 12.2 4.2 1.2 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 Nucleoside_tran PF01733.13 ERZ95329.1 - 0.11 11.6 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 Nucleoside transporter DUF465 PF04325.8 ERZ95329.1 - 0.44 10.2 4.6 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF465) DUF2630 PF10944.3 ERZ95329.1 - 0.57 10.3 5.3 0.72 9.9 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) HMA PF00403.21 ERZ95330.1 - 2.6e-14 53.1 0.4 2.9e-14 52.9 0.3 1.0 1 0 0 1 1 1 1 Heavy-metal-associated domain NapD PF03927.8 ERZ95330.1 - 0.031 14.1 0.1 0.037 13.8 0.0 1.1 1 0 0 1 1 1 0 NapD protein CdhC PF03598.10 ERZ95330.1 - 0.058 11.8 0.0 0.058 11.8 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit Pkinase PF00069.20 ERZ95331.1 - 7.4e-31 107.2 0.0 9.9e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95331.1 - 2.4e-28 98.9 0.0 3.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ95331.1 - 0.0025 17.5 0.1 0.005 16.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ95331.1 - 0.089 11.7 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Kinase-like ATE_C PF04377.10 ERZ95332.1 - 5.1e-47 159.1 4.9 9.4e-47 158.2 3.4 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 ERZ95332.1 - 2.8e-19 68.7 5.4 4.5e-19 68.0 0.5 3.0 3 0 0 3 3 3 1 Arginine-tRNA-protein transferase, N terminus GPI-anchored PF10342.4 ERZ95333.1 - 1.1e-07 32.2 2.4 1.1e-07 32.2 1.7 1.7 1 1 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.1 ERZ95333.1 - 0.0078 15.7 1.1 0.0093 15.4 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) RVT_1 PF00078.22 ERZ95334.1 - 2.7e-06 26.9 0.0 2.9e-06 26.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF659 PF04937.10 ERZ95335.1 - 5e-14 52.0 0.0 9.5e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Bac_transf PF02397.11 ERZ95335.1 - 0.081 12.0 0.1 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial sugar transferase Picorna_P3A PF06363.6 ERZ95339.1 - 0.011 15.7 1.0 0.21 11.6 0.0 2.2 1 1 1 2 2 2 0 Picornaviridae P3A protein ARL2_Bind_BART PF11527.3 ERZ95339.1 - 0.012 15.3 2.6 0.022 14.5 1.8 1.4 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART Lyase_catalyt PF09093.6 ERZ95339.1 - 0.015 14.2 1.4 0.018 13.9 1.0 1.0 1 0 0 1 1 1 0 Lyase, catalytic EIF_2_alpha PF07541.7 ERZ95339.1 - 0.034 13.8 1.0 0.062 13.0 0.7 1.6 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Chalcone PF02431.10 ERZ95339.1 - 0.051 12.9 0.2 0.098 12.0 0.1 1.6 2 0 0 2 2 2 0 Chalcone-flavanone isomerase PaaB PF06243.6 ERZ95339.1 - 0.07 13.2 1.0 0.14 12.3 0.7 1.7 1 1 0 1 1 1 0 Phenylacetic acid degradation B Recombinase PF07508.8 ERZ95339.1 - 0.11 12.6 3.0 0.083 13.1 1.1 1.5 2 0 0 2 2 2 0 Recombinase DUF3725 PF12523.3 ERZ95339.1 - 0.65 10.1 4.1 0.71 9.9 0.5 2.5 2 2 2 4 4 4 0 Protein of unknown function (DUF3725) LRR_4 PF12799.2 ERZ95344.1 - 0.00032 20.2 57.0 0.32 10.6 3.0 8.4 2 2 4 6 6 6 5 Leucine Rich repeats (2 copies) AAA_17 PF13207.1 ERZ95344.1 - 0.003 18.3 1.0 0.025 15.3 0.2 2.6 2 1 0 2 2 2 1 AAA domain LRR_7 PF13504.1 ERZ95344.1 - 0.046 13.9 39.5 2.4 8.7 0.5 10.8 8 4 1 9 9 9 0 Leucine rich repeat MMR_HSR1 PF01926.18 ERZ95344.1 - 0.069 13.1 1.3 0.13 12.2 0.4 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase LRR_1 PF00560.28 ERZ95344.1 - 0.57 10.4 42.8 12 6.3 0.0 10.3 5 3 4 9 9 9 0 Leucine Rich Repeat Pkinase_Tyr PF07714.12 ERZ95345.1 - 2.3e-54 184.2 0.0 2.7e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95345.1 - 2.1e-52 177.8 0.1 2.6e-52 177.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ95345.1 - 0.0027 17.4 0.0 0.02 14.6 0.1 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ95345.1 - 0.0044 16.3 0.6 0.0097 15.2 0.2 1.6 1 1 0 2 2 2 1 RIO1 family ABC1 PF03109.11 ERZ95345.1 - 0.0057 16.6 0.0 0.013 15.4 0.0 1.6 1 1 0 1 1 1 1 ABC1 family Kinase-like PF14531.1 ERZ95345.1 - 0.0088 15.0 0.0 0.02 13.8 0.0 1.5 2 0 0 2 2 2 1 Kinase-like YjeF_N PF03853.10 ERZ95345.1 - 0.019 14.5 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Kdo PF06293.9 ERZ95345.1 - 0.056 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2322 PF10084.4 ERZ95345.1 - 0.083 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2322) KH_1 PF00013.24 ERZ95347.1 - 4.7e-09 35.7 1.1 8.5e-09 34.9 0.7 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ95347.1 - 1.5e-07 30.8 1.9 5.6e-07 29.0 0.2 2.3 2 0 0 2 2 2 1 KH domain KH_2 PF07650.12 ERZ95347.1 - 0.038 13.5 3.4 0.087 12.3 0.0 2.3 2 0 0 2 2 2 0 KH domain Peptidase_S46 PF10459.4 ERZ95347.1 - 0.11 10.8 4.5 0.12 10.7 3.1 1.0 1 0 0 1 1 1 0 Peptidase S46 RP-C_C PF11800.3 ERZ95347.1 - 0.41 10.3 4.5 0.47 10.1 3.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region OATP PF03137.15 ERZ95348.1 - 0.028 12.4 0.4 0.033 12.2 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Atrophin-1 PF03154.10 ERZ95348.1 - 0.043 11.9 14.4 0.059 11.5 10.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family Chlorosome_CsmC PF11098.3 ERZ95348.1 - 0.074 12.7 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorosome envelope protein C Mis12 PF05859.7 ERZ95348.1 - 0.1 12.3 0.1 0.1 12.3 0.1 2.2 1 1 1 2 2 2 0 Mis12 protein Zip PF02535.17 ERZ95348.1 - 0.97 8.3 3.1 1.3 7.9 2.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Trypan_PARP PF05887.6 ERZ95348.1 - 6.2 6.6 10.0 2.2 8.1 5.1 1.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Upf2 PF04050.9 ERZ95349.1 - 2.3e-17 63.2 0.3 2.7e-17 63.0 0.2 1.1 1 0 0 1 1 1 1 Up-frameshift suppressor 2 DUF4108 PF13390.1 ERZ95349.1 - 0.0054 16.4 0.1 0.0058 16.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4108) LRR_4 PF12799.2 ERZ95350.1 - 2.6e-06 26.9 28.5 0.15 11.6 7.7 5.0 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ95350.1 - 0.00062 19.4 23.2 0.067 12.9 5.4 4.2 1 1 3 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ERZ95350.1 - 0.0061 16.4 24.1 3.3 8.1 0.4 6.3 1 1 7 8 8 8 4 Leucine Rich Repeat SLEI_Leptospira PF07620.6 ERZ95350.1 - 0.0089 15.7 1.4 0.68 9.8 0.1 2.8 2 0 0 2 2 2 1 SLEI LRR_7 PF13504.1 ERZ95350.1 - 0.025 14.7 23.5 1.4 9.4 0.2 6.8 3 2 2 5 5 5 0 Leucine rich repeat Stn1_C PF12659.2 ERZ95350.1 - 0.04 13.7 4.7 0.61 9.9 0.5 2.3 1 1 1 2 2 2 0 Telomere capping C-terminal wHTH OapA PF04225.7 ERZ95350.1 - 0.049 13.5 0.1 1.9 8.4 0.0 2.4 1 1 2 3 3 3 0 Opacity-associated protein A LysM-like domain LRR_6 PF13516.1 ERZ95350.1 - 0.42 10.8 23.9 2.1 8.6 0.3 6.3 1 1 2 4 4 4 0 Leucine Rich repeat LRRNT PF01462.13 ERZ95350.1 - 0.74 9.3 5.8 4.4 6.8 0.2 3.3 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain V-set_CD47 PF08204.6 ERZ95350.1 - 2.4 7.9 9.8 0.69 9.6 1.6 2.6 1 1 1 2 2 2 0 CD47 immunoglobulin-like domain Pkinase_Tyr PF07714.12 ERZ95351.1 - 5.9e-73 245.1 0.0 1.5e-41 142.1 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95351.1 - 7.2e-69 231.8 3.0 7.5e-41 139.9 0.3 2.0 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ERZ95351.1 - 9e-08 31.6 2.4 0.0016 17.8 0.3 2.6 2 1 0 2 2 2 2 RIO1 family APH PF01636.18 ERZ95351.1 - 5.1e-06 26.4 2.2 0.011 15.4 0.2 2.5 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ95351.1 - 5.3e-06 25.5 0.0 0.037 12.9 0.0 2.6 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.9 ERZ95351.1 - 3.9e-05 22.8 2.5 0.079 12.0 0.2 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ95351.1 - 0.00016 21.0 0.3 0.015 14.6 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL WaaY PF06176.6 ERZ95351.1 - 0.0028 16.9 0.8 1.2 8.3 0.1 2.7 3 0 0 3 3 3 2 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ERZ95353.1 - 1.4e-11 44.6 6.4 1.2e-08 35.2 0.1 4.5 4 1 0 4 4 4 2 Sel1 repeat TPR_2 PF07719.12 ERZ95353.1 - 0.53 10.3 4.2 32 4.7 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TLD PF07534.11 ERZ95354.1 - 1.1e-06 28.7 2.7 1.2e-06 28.5 1.9 1.1 1 0 0 1 1 1 1 TLD BTB PF00651.26 ERZ95355.1 - 4.8e-12 45.8 0.1 6.1e-12 45.5 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ95356.1 - 0.003 17.5 0.0 0.0056 16.6 0.0 1.5 1 0 0 1 1 1 1 TLD CPSase_L_chain PF00289.17 ERZ95357.1 - 1.7e-40 137.5 0.0 2.4e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D2 PF02786.12 ERZ95357.1 - 1.5e-14 53.8 0.1 2.6e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 ERZ95357.1 - 5.3e-06 25.4 0.0 6e-06 25.2 0.0 1.0 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Cpn60_TCP1 PF00118.19 ERZ95358.1 - 1.1e-145 486.0 16.0 1.2e-145 485.8 11.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.13 ERZ95358.1 - 0.00066 18.9 0.2 0.0025 17.0 0.0 2.0 2 0 0 2 2 2 1 Telomere recombination NicO PF03824.11 ERZ95359.1 - 1.2e-76 257.7 15.1 1.2e-76 257.7 10.5 1.5 2 0 0 2 2 2 1 High-affinity nickel-transport protein Fic PF02661.13 ERZ95361.1 - 9.3e-11 42.2 0.0 1.5e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Fic/DOC family Na_Ca_ex PF01699.19 ERZ95362.1 - 5.5e-13 48.7 8.7 5.5e-13 48.7 6.0 1.5 1 1 1 2 2 2 1 Sodium/calcium exchanger protein Pkinase_Tyr PF07714.12 ERZ95363.1 - 1.5e-51 174.9 0.0 2.4e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95363.1 - 9.7e-47 159.2 1.3 1.4e-46 158.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain AAA_17 PF13207.1 ERZ95363.1 - 2.7e-10 41.1 1.9 0.00029 21.6 0.0 3.5 3 2 0 3 3 2 2 AAA domain ABC_tran PF00005.22 ERZ95363.1 - 2.8e-08 34.1 3.6 0.0033 17.7 0.0 2.9 2 1 0 2 2 2 2 ABC transporter AIG1 PF04548.11 ERZ95363.1 - 1.5e-07 30.7 14.4 2.8e-06 26.5 0.9 4.0 2 2 0 3 3 3 1 AIG1 family MMR_HSR1 PF01926.18 ERZ95363.1 - 2.4e-07 30.7 6.5 0.00039 20.3 0.6 3.5 2 2 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 ERZ95363.1 - 7.7e-07 28.5 0.0 0.012 15.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ERZ95363.1 - 1.4e-06 27.9 0.0 0.038 13.4 0.0 2.6 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ERZ95363.1 - 1.4e-06 27.6 1.1 0.00047 19.3 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 ERZ95363.1 - 5.4e-06 26.0 0.0 0.092 12.2 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.1 ERZ95363.1 - 1.2e-05 25.3 0.0 0.0026 17.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Septin PF00735.13 ERZ95363.1 - 1.5e-05 24.1 1.3 0.049 12.6 0.0 3.5 3 1 0 3 3 3 2 Septin T2SE PF00437.15 ERZ95363.1 - 2.6e-05 23.2 0.1 0.052 12.4 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.1 ERZ95363.1 - 8.3e-05 22.7 0.0 0.79 9.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 ERZ95363.1 - 0.00012 22.1 0.1 0.17 12.0 0.0 2.8 2 0 0 2 2 2 1 RNA helicase PduV-EutP PF10662.4 ERZ95363.1 - 0.00016 21.1 0.0 0.53 9.7 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 ERZ95363.1 - 0.00021 20.9 0.2 0.46 10.1 0.0 3.2 3 0 0 3 3 3 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ERZ95363.1 - 0.00033 20.1 0.0 0.43 9.9 0.0 2.9 3 0 0 3 3 3 2 AAA-like domain AAA_18 PF13238.1 ERZ95363.1 - 0.00058 20.1 22.0 0.022 15.0 0.1 5.2 3 3 2 6 6 3 2 AAA domain AAA_33 PF13671.1 ERZ95363.1 - 0.0033 17.2 0.0 0.63 9.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 ERZ95363.1 - 0.011 15.5 6.6 0.78 9.5 0.0 3.8 3 1 0 4 4 4 0 Domain of unknown function DUF87 ATP_bind_1 PF03029.12 ERZ95363.1 - 0.016 14.7 0.6 0.27 10.7 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NACHT PF05729.7 ERZ95363.1 - 0.018 14.7 0.0 2.1 7.9 0.0 3.5 3 1 1 5 5 5 0 NACHT domain APH PF01636.18 ERZ95363.1 - 0.021 14.5 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family APS_kinase PF01583.15 ERZ95363.1 - 0.023 14.3 0.0 1 8.9 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase Miro PF08477.8 ERZ95363.1 - 0.026 15.0 3.2 7 7.1 0.1 3.4 2 2 1 3 3 2 0 Miro-like protein Mg_chelatase PF01078.16 ERZ95363.1 - 0.026 13.6 0.0 3.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Dynamin_N PF00350.18 ERZ95363.1 - 0.039 13.7 8.9 0.043 13.6 0.2 3.4 3 0 0 3 3 3 0 Dynamin family Zeta_toxin PF06414.7 ERZ95363.1 - 0.051 12.6 0.0 3.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.9 ERZ95363.1 - 0.054 13.2 0.0 1.5 8.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF3987 PF13148.1 ERZ95363.1 - 0.077 11.5 0.0 0.25 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) SMC_N PF02463.14 ERZ95363.1 - 1.5 8.0 6.8 0.7 9.0 0.1 3.4 3 1 1 4 4 4 0 RecF/RecN/SMC N terminal domain NmrA PF05368.8 ERZ95364.1 - 6.6e-37 126.9 0.1 7.8e-37 126.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ95364.1 - 1.4e-12 48.0 0.0 1.9e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ERZ95364.1 - 1.3e-05 24.7 0.0 2.3e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 ERZ95364.1 - 1.6e-05 24.9 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.14 ERZ95364.1 - 3.9e-05 22.4 0.0 6.3e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ERZ95364.1 - 0.0002 21.0 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 KR domain TrkA_N PF02254.13 ERZ95364.1 - 0.0032 17.4 0.3 0.0061 16.5 0.0 1.6 2 0 0 2 2 2 1 TrkA-N domain Saccharop_dh PF03435.13 ERZ95364.1 - 0.0055 15.7 0.1 0.0084 15.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 ERZ95364.1 - 0.014 15.7 0.0 0.034 14.5 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent zf-C2H2_4 PF13894.1 ERZ95366.1 - 0.0075 16.5 16.7 0.14 12.5 0.7 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ERZ95366.1 - 0.012 15.8 12.7 0.04 14.2 1.8 3.9 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 ERZ95366.1 - 0.06 13.7 22.9 0.093 13.1 0.7 4.5 5 0 0 5 5 5 0 Zinc finger, C2H2 type TRAM PF01938.15 ERZ95366.1 - 0.08 12.7 0.3 6.4 6.6 0.0 2.3 1 1 1 2 2 2 0 TRAM domain zf-Di19 PF05605.7 ERZ95366.1 - 3 8.0 7.9 0.58 10.3 2.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Apolipoprotein PF01442.13 ERZ95367.1 - 0.011 15.2 0.3 0.029 13.8 0.2 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Phage-tail_1 PF09097.5 ERZ95367.1 - 0.038 13.5 0.1 0.043 13.3 0.0 1.1 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Baculo_PEP_C PF04513.7 ERZ95367.1 - 0.061 13.1 0.9 0.28 11.0 0.6 1.9 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 ERZ95367.1 - 0.12 11.9 0.8 0.16 11.5 0.6 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1104 PF06518.6 ERZ95367.1 - 0.12 12.4 1.2 0.34 11.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) RVT_1 PF00078.22 ERZ95368.1 - 5.1e-11 42.3 0.0 1.5e-09 37.5 0.0 2.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DS PF01916.12 ERZ95368.1 - 0.021 13.9 0.3 0.031 13.4 0.2 1.2 1 0 0 1 1 1 0 Deoxyhypusine synthase Cnl2_NKP2 PF09447.5 ERZ95369.1 - 0.0049 16.5 0.4 0.27 10.9 0.0 2.6 2 0 0 2 2 2 1 Cnl2/NKP2 family protein HBS1_N PF08938.5 ERZ95369.1 - 0.053 13.6 7.2 0.31 11.1 0.3 3.9 2 1 2 4 4 4 0 HBS1 N-terminus GSP_synth PF03738.9 ERZ95369.1 - 0.084 13.1 0.4 0.31 11.3 0.3 2.0 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp BTB PF00651.26 ERZ95373.1 - 7e-16 58.1 1.0 1.7e-15 56.9 0.7 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ95373.1 - 7.6e-12 45.4 4.6 8.4e-12 45.2 1.1 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ95373.1 - 0.0022 17.7 0.6 0.012 15.4 0.5 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ95373.1 - 0.036 13.2 0.1 0.061 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Leukemia_assc_2 PF15197.1 ERZ95373.1 - 1.2 8.8 6.0 1.4 8.6 0.1 3.4 3 0 0 3 3 3 0 Leukemia-associated protein 2 HBS1_N PF08938.5 ERZ95375.1 - 7.8e-05 22.7 10.2 0.33 11.0 0.2 4.8 3 2 1 4 4 4 4 HBS1 N-terminus Lsm_interact PF05391.6 ERZ95375.1 - 0.037 13.4 0.1 0.037 13.4 0.1 2.8 3 0 0 3 3 3 0 Lsm interaction motif DSPc PF00782.15 ERZ95375.1 - 5.4 6.6 6.4 6.9 6.2 0.3 3.0 1 1 1 3 3 3 0 Dual specificity phosphatase, catalytic domain Pkinase_Tyr PF07714.12 ERZ95376.1 - 4.2e-87 291.4 0.4 4.6e-54 183.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95376.1 - 7.1e-87 290.8 4.1 1.9e-52 178.0 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ERZ95376.1 - 9.9e-09 34.8 0.6 0.00062 19.1 0.0 2.5 2 0 0 2 2 2 2 RIO1 family Kdo PF06293.9 ERZ95376.1 - 5e-07 28.9 0.3 0.015 14.4 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95376.1 - 1.4e-06 28.2 0.1 0.015 15.0 0.0 2.6 3 0 0 3 3 3 2 Phosphotransferase enzyme family Fic_N PF13784.1 ERZ95376.1 - 0.029 14.2 0.0 0.15 11.9 0.0 2.1 2 0 0 2 2 2 0 Fic/DOC family N-terminal P4Ha_N PF08336.6 ERZ95377.1 - 0.0011 18.8 1.2 0.0014 18.4 0.8 1.2 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2730 PF10805.3 ERZ95377.1 - 0.022 14.4 0.9 0.031 14.0 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) DUF972 PF06156.8 ERZ95377.1 - 0.082 13.2 3.9 0.12 12.7 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 ERZ95377.1 - 0.71 9.4 3.0 0.73 9.3 2.1 1.1 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ERZ95377.1 - 4.2 7.3 11.8 0.65 10.0 1.7 3.0 3 0 0 3 3 3 0 bZIP transcription factor F-box-like PF12937.2 ERZ95379.1 - 2.9e-05 23.7 1.6 5.1e-05 22.9 1.1 1.4 1 0 0 1 1 1 1 F-box-like Staphostatin_B PF09023.5 ERZ95379.1 - 0.02 14.7 0.6 0.03 14.1 0.5 1.4 1 0 0 1 1 1 0 Staphostatin B F-box PF00646.28 ERZ95379.1 - 0.029 14.0 0.7 0.081 12.6 0.5 1.9 1 0 0 1 1 1 0 F-box domain CDC45 PF02724.9 ERZ95379.1 - 0.076 11.0 0.2 0.094 10.7 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Pox_A3L PF05288.6 ERZ95379.1 - 0.57 9.9 5.4 4.4 7.1 0.2 2.7 3 0 0 3 3 3 0 Poxvirus A3L Protein PRANC PF09372.5 ERZ95379.1 - 8.7 6.3 10.0 1.9 8.5 0.1 2.3 2 1 0 2 2 2 0 PRANC domain Iso_dh PF00180.15 ERZ95380.1 - 6.3e-68 229.2 0.0 7.4e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CheY-binding PF09078.6 ERZ95381.1 - 0.14 12.1 0.5 22 5.1 0.0 2.7 3 0 0 3 3 3 0 CheY binding CCDC-167 PF15188.1 ERZ95381.1 - 0.56 10.1 7.8 3.2 7.7 1.0 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF2346 PF09803.4 ERZ95381.1 - 1.3 8.9 4.9 0.91 9.4 0.6 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) UPRTase PF14681.1 ERZ95382.1 - 5.7e-63 211.8 0.0 8.1e-63 211.3 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.13 ERZ95382.1 - 1e-61 207.9 0.5 1.9e-61 207.0 0.1 1.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 ERZ95382.1 - 1.9e-07 31.9 0.3 6.4e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ERZ95382.1 - 1e-06 29.1 0.6 1.9e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain CPT PF07931.7 ERZ95382.1 - 3.5e-05 23.4 0.0 9.5e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein CoaE PF01121.15 ERZ95382.1 - 0.043 13.2 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Dephospho-CoA kinase Zeta_toxin PF06414.7 ERZ95382.1 - 0.091 11.8 0.0 0.54 9.3 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.1 ERZ95382.1 - 0.12 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 ERZ95383.1 - 2.5e-27 93.7 0.9 3e-07 30.0 0.1 5.4 5 1 0 5 5 5 4 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ERZ95383.1 - 0.00096 18.0 0.4 0.048 12.4 0.0 2.2 1 1 1 2 2 2 2 Coatomer WD associated region Gmad1 PF10647.4 ERZ95383.1 - 0.0028 17.0 0.3 0.0041 16.5 0.2 1.2 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain PQQ_2 PF13360.1 ERZ95383.1 - 0.005 16.3 0.1 0.016 14.6 0.1 1.9 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.3 ERZ95383.1 - 0.022 12.9 0.2 0.034 12.2 0.1 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 LSM PF01423.17 ERZ95384.1 - 5.3e-21 73.9 0.2 5.9e-21 73.7 0.1 1.0 1 0 0 1 1 1 1 LSM domain Cas_NE0113 PF09623.5 ERZ95384.1 - 0.034 13.6 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) SM-ATX PF14438.1 ERZ95384.1 - 0.085 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain KH_1 PF00013.24 ERZ95385.1 - 2.7e-10 39.7 0.0 6.8e-07 28.8 0.0 2.7 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 ERZ95385.1 - 5.3e-06 25.9 4.2 0.00013 21.5 0.0 3.3 3 0 0 3 3 3 2 KH domain Pkinase_Tyr PF07714.12 ERZ95386.1 - 1.8e-39 135.3 0.0 2.4e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95386.1 - 4.8e-38 130.7 0.0 1e-37 129.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ERZ95386.1 - 0.012 14.7 0.0 0.024 13.7 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95386.1 - 0.018 14.7 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family T4_Gp59_C PF08994.5 ERZ95388.1 - 0.086 12.9 4.5 0.14 12.3 1.9 2.4 1 1 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term IDO PF01231.13 ERZ95389.1 - 2.6e-60 204.0 0.0 3.6e-60 203.5 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Herpes_U47 PF05467.6 ERZ95389.1 - 0.03 12.2 0.0 0.046 11.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 Gln-synt_C PF00120.19 ERZ95391.1 - 1.5e-63 214.3 0.0 1.9e-63 214.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 ERZ95391.1 - 1.8e-18 65.8 0.0 2.9e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Myb_DNA-binding PF00249.26 ERZ95392.1 - 2.6e-28 97.8 10.9 1.1e-09 38.1 0.0 4.8 5 0 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ95392.1 - 7.4e-18 64.4 18.8 1.3e-05 25.1 0.2 5.5 4 1 1 5 5 5 4 Myb-like DNA-binding domain Annexin PF00191.15 ERZ95392.1 - 0.13 12.1 0.1 11 5.9 0.0 3.0 3 0 0 3 3 3 0 Annexin zf-UBP PF02148.14 ERZ95394.1 - 0.34 11.0 3.8 0.44 10.6 1.6 2.0 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Pkinase_Tyr PF07714.12 ERZ95395.1 - 2e-19 69.6 0.1 4.6e-18 65.2 0.1 2.0 1 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95395.1 - 4.8e-18 65.2 0.1 6.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ95395.1 - 0.0045 16.7 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ95395.1 - 0.032 13.5 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family RRM_6 PF14259.1 ERZ95397.1 - 0.015 15.3 0.0 0.076 13.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Arch_ATPase PF01637.13 ERZ95399.1 - 3.2e-15 56.4 0.1 5.9e-15 55.6 0.1 1.4 1 1 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ERZ95399.1 - 4.5e-08 33.3 0.0 9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA12 PF10443.4 ERZ95399.1 - 6.4e-08 31.5 0.5 0.0048 15.4 0.0 2.1 1 1 0 2 2 2 2 RNA12 protein AAA PF00004.24 ERZ95399.1 - 6.8e-07 29.5 0.0 4.3e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ERZ95399.1 - 7.2e-07 29.1 0.3 0.034 14.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain DUF2075 PF09848.4 ERZ95399.1 - 0.00011 21.3 0.0 0.00015 20.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 ERZ95399.1 - 0.00015 21.8 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ERZ95399.1 - 0.0037 18.0 0.0 0.011 16.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 ERZ95399.1 - 0.0042 17.3 0.1 0.015 15.6 0.0 2.1 2 1 0 2 2 1 1 AAA domain MobB PF03205.9 ERZ95399.1 - 0.0049 16.5 0.0 0.0085 15.7 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_21 PF13304.1 ERZ95399.1 - 0.011 15.7 2.5 0.011 15.7 1.7 2.4 1 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 ERZ95399.1 - 0.012 15.9 2.7 2.5 8.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 ERZ95399.1 - 0.013 15.4 0.2 0.053 13.4 0.1 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase TK PF00265.13 ERZ95399.1 - 0.014 14.9 0.1 2.5 7.6 0.0 2.2 1 1 1 2 2 2 0 Thymidine kinase AAA_11 PF13086.1 ERZ95399.1 - 0.058 12.9 0.0 0.17 11.4 0.0 1.7 1 1 1 2 2 2 0 AAA domain MutS_V PF00488.16 ERZ95399.1 - 0.063 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 MutS domain V AAA_28 PF13521.1 ERZ95399.1 - 0.068 13.1 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 ERZ95399.1 - 0.075 12.5 0.0 0.33 10.4 0.0 2.1 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 ERZ95399.1 - 0.11 11.9 0.0 0.98 8.7 0.0 2.6 2 2 1 3 3 3 0 AAA domain AAA_33 PF13671.1 ERZ95399.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 ERZ95399.1 - 0.12 11.8 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.1 ERZ95399.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ERZ95399.1 - 0.16 11.0 0.0 0.33 10.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.10 ERZ95399.1 - 0.17 11.6 0.0 0.37 10.4 0.0 1.5 1 0 0 1 1 1 0 NTPase RRM_6 PF14259.1 ERZ95400.1 - 0.00061 19.7 0.1 0.0085 16.0 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) U3_assoc_6 PF08640.6 ERZ95400.1 - 0.061 13.0 0.5 0.89 9.3 0.1 2.5 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 HMG_box PF00505.14 ERZ95402.1 - 5.7e-07 29.7 0.0 9.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ95402.1 - 2.3e-06 27.8 0.0 3.5e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain WSC PF01822.14 ERZ95403.1 - 0.016 15.1 12.9 0.016 15.1 5.9 2.6 1 1 1 2 2 2 0 WSC domain Borrelia_lipo_2 PF06238.6 ERZ95405.1 - 2.8 8.0 6.3 2.1 8.4 2.7 1.9 1 1 1 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein His_biosynth PF00977.16 ERZ95406.1 - 6.4e-27 94.3 0.0 7.1e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Patched PF02460.13 ERZ95407.1 - 0.056 11.3 0.1 0.07 11.0 0.1 1.1 1 0 0 1 1 1 0 Patched family CutC PF03932.9 ERZ95409.1 - 3.9e-77 258.0 0.3 4.9e-77 257.7 0.2 1.1 1 0 0 1 1 1 1 CutC family TMP-TENI PF02581.12 ERZ95409.1 - 0.0046 16.0 0.0 0.012 14.7 0.0 1.7 1 1 1 2 2 2 1 Thiamine monophosphate synthase/TENI BtpA PF03437.10 ERZ95409.1 - 0.012 14.9 0.3 0.16 11.1 0.1 2.2 1 1 0 2 2 2 0 BtpA family QRPTase_C PF01729.14 ERZ95409.1 - 0.022 14.2 0.2 0.049 13.1 0.1 1.7 1 1 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain B12-binding PF02310.14 ERZ95409.1 - 0.034 14.0 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 B12 binding domain cobW PF02492.14 ERZ95410.1 - 4.6e-47 159.7 0.1 6.3e-47 159.3 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 ERZ95410.1 - 3.1e-11 42.8 0.0 6.7e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Arch_ATPase PF01637.13 ERZ95410.1 - 0.00098 18.8 0.1 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ERZ95410.1 - 0.003 17.5 0.2 0.018 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ERZ95410.1 - 0.007 16.5 0.4 0.023 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ERZ95410.1 - 0.013 14.3 0.2 0.029 13.2 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 ERZ95410.1 - 0.013 15.7 0.5 0.031 14.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 ERZ95410.1 - 0.018 14.7 0.1 0.054 13.2 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ERZ95410.1 - 0.026 13.9 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_14 PF13173.1 ERZ95410.1 - 0.026 14.4 0.2 0.12 12.2 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_19 PF13245.1 ERZ95410.1 - 0.036 13.8 0.2 0.097 12.4 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain Viral_helicase1 PF01443.13 ERZ95410.1 - 0.054 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SRPRB PF09439.5 ERZ95410.1 - 0.097 11.8 0.1 0.24 10.5 0.1 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.1 ERZ95410.1 - 0.11 11.9 0.1 0.31 10.5 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ArgK PF03308.11 ERZ95410.1 - 0.12 11.1 1.1 1.1 7.9 0.1 2.5 3 0 0 3 3 3 0 ArgK protein Miro PF08477.8 ERZ95410.1 - 0.12 12.8 0.1 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein Ion_trans PF00520.26 ERZ95411.1 - 3.4e-05 23.1 3.7 3.4e-05 23.1 2.5 2.0 2 0 0 2 2 2 2 Ion transport protein Metallophos PF00149.23 ERZ95412.1 - 7.9e-05 22.1 1.5 0.0002 20.8 1.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_18 PF13238.1 ERZ95413.1 - 6.1e-27 94.4 1.1 6.1e-27 94.4 0.1 1.5 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 ERZ95413.1 - 2.4e-14 54.1 0.2 3.3e-14 53.7 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ERZ95413.1 - 0.00013 21.8 0.0 0.0019 18.1 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA PF00004.24 ERZ95413.1 - 0.00021 21.4 0.0 0.00048 20.3 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 ERZ95413.1 - 0.00046 20.1 0.0 0.0011 18.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ERZ95413.1 - 0.0012 18.8 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.10 ERZ95413.1 - 0.0015 18.3 0.1 0.004 16.8 0.0 1.8 2 0 0 2 2 2 1 NTPase Zeta_toxin PF06414.7 ERZ95413.1 - 0.0031 16.6 0.0 0.0079 15.3 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin SKI PF01202.17 ERZ95413.1 - 0.0039 17.0 0.1 0.0083 16.0 0.0 1.6 1 1 0 1 1 1 1 Shikimate kinase AAA_10 PF12846.2 ERZ95413.1 - 0.0046 16.4 0.6 0.011 15.2 0.1 1.7 2 0 0 2 2 2 1 AAA-like domain AAA_29 PF13555.1 ERZ95413.1 - 0.0073 15.8 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.1 ERZ95413.1 - 0.0086 15.9 0.2 0.014 15.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ERZ95413.1 - 0.011 15.5 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ERZ95413.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 ERZ95413.1 - 0.014 14.9 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ERZ95413.1 - 0.018 15.1 0.5 0.052 13.6 0.1 1.8 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 ERZ95413.1 - 0.019 14.0 0.0 0.042 12.9 0.0 1.7 2 0 0 2 2 2 0 KaiC Cytidylate_kin2 PF13189.1 ERZ95413.1 - 0.023 14.6 0.1 0.05 13.5 0.1 1.8 1 1 0 1 1 1 0 Cytidylate kinase-like family DUF815 PF05673.8 ERZ95413.1 - 0.025 13.4 0.1 0.053 12.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF2018 PF09442.5 ERZ95413.1 - 0.037 14.6 3.6 0.27 11.8 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF2018) T2SE PF00437.15 ERZ95413.1 - 0.042 12.7 1.2 0.05 12.4 0.1 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 ERZ95413.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 ERZ95413.1 - 0.065 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ArgK PF03308.11 ERZ95413.1 - 0.088 11.5 0.1 0.18 10.5 0.0 1.5 2 0 0 2 2 2 0 ArgK protein Sigma54_activat PF00158.21 ERZ95413.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.9 ERZ95413.1 - 0.16 11.6 0.5 0.33 10.6 0.1 1.7 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FAR1 PF03101.10 ERZ95414.1 - 8.4e-12 45.4 0.8 1.3e-11 44.8 0.5 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.6 ERZ95414.1 - 9.6e-06 25.7 0.8 1.5e-05 25.1 0.5 1.3 1 0 0 1 1 1 1 Transcription factor AFT RTC4 PF14474.1 ERZ95415.1 - 1e-11 44.8 0.0 1e-11 44.8 0.0 1.0 1 0 0 1 1 1 1 RTC4-like domain Pkinase_Tyr PF07714.12 ERZ95420.1 - 2.8e-07 29.8 0.0 4.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95420.1 - 0.0086 15.2 0.0 0.023 13.8 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain NMO PF03060.10 ERZ95422.1 - 2.1e-49 168.4 0.0 7.9e-49 166.5 0.0 1.7 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 ERZ95422.1 - 3.1e-05 23.0 0.3 0.00073 18.5 0.2 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 ERZ95422.1 - 7.3e-05 21.8 0.1 0.00011 21.2 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase FMN_dh PF01070.13 ERZ95422.1 - 0.00016 20.6 0.1 0.00032 19.6 0.1 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glyco_hydro_79n PF03662.9 ERZ95422.1 - 0.011 14.3 0.1 0.022 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain Methyltransf_32 PF13679.1 ERZ95423.1 - 1e-24 86.8 2.8 2e-24 85.8 1.9 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ95423.1 - 0.0035 17.9 0.0 0.0084 16.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ERZ95423.1 - 0.015 14.6 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.1 ERZ95423.1 - 0.025 14.3 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ95423.1 - 0.027 14.0 0.2 0.13 11.8 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.26 ERZ95425.1 - 4.7e-05 23.3 0.1 0.00011 22.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Tropomyosin_1 PF12718.2 ERZ95426.1 - 3.7e-18 65.7 36.6 7.6e-13 48.5 12.6 2.5 1 1 1 2 2 2 2 Tropomyosin like Tropomyosin PF00261.15 ERZ95426.1 - 1.8e-09 37.0 32.9 4.4e-09 35.7 22.8 1.5 1 1 0 1 1 1 1 Tropomyosin Myosin_tail_1 PF01576.14 ERZ95426.1 - 0.00024 19.0 31.1 0.00027 18.8 21.5 1.0 1 0 0 1 1 1 1 Myosin tail GAS PF13851.1 ERZ95426.1 - 0.00052 19.2 31.6 0.00087 18.5 21.9 1.3 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 ERZ95426.1 - 0.00092 19.0 35.3 0.0015 18.3 24.5 1.4 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 ERZ95426.1 - 0.001 18.2 2.3 0.0013 18.0 1.6 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein ATG16 PF08614.6 ERZ95426.1 - 0.0013 18.6 12.8 0.0013 18.6 8.9 2.0 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) YlqD PF11068.3 ERZ95426.1 - 0.0038 17.2 10.9 0.0038 17.2 7.5 2.1 1 1 1 2 2 2 1 YlqD protein Laminin_I PF06008.9 ERZ95426.1 - 0.0071 15.6 14.3 0.0071 15.6 9.9 2.1 1 1 1 2 2 2 2 Laminin Domain I EzrA PF06160.7 ERZ95426.1 - 0.0095 14.1 24.3 0.024 12.8 16.1 1.7 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Laminin_II PF06009.7 ERZ95426.1 - 0.022 14.5 16.1 0.021 14.5 9.7 1.9 1 1 1 2 2 2 0 Laminin Domain II TMF_DNA_bd PF12329.3 ERZ95426.1 - 0.023 14.5 41.1 0.56 10.0 7.3 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.3 ERZ95426.1 - 0.024 14.5 28.0 0.085 12.7 8.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding IZUMO PF15005.1 ERZ95426.1 - 0.029 14.4 13.4 0.11 12.4 9.3 1.8 1 1 0 1 1 1 0 Izumo sperm-egg fusion Cast PF10174.4 ERZ95426.1 - 0.03 12.4 27.9 0.038 12.0 19.4 1.2 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Spc7 PF08317.6 ERZ95426.1 - 0.035 12.7 30.1 0.25 9.9 6.1 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.9 ERZ95426.1 - 0.041 13.4 32.6 0.66 9.5 22.4 1.9 1 1 0 1 1 1 0 IncA protein DUF948 PF06103.6 ERZ95426.1 - 0.041 13.7 14.7 0.9 9.4 4.3 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Lebercilin PF15619.1 ERZ95426.1 - 0.043 13.2 30.2 0.055 12.8 20.9 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Bacillus_HBL PF05791.6 ERZ95426.1 - 0.045 13.1 18.1 0.3 10.4 6.7 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ERM PF00769.14 ERZ95426.1 - 0.046 13.2 33.3 0.054 13.0 23.1 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family WXG100 PF06013.7 ERZ95426.1 - 0.047 13.6 5.5 0.61 10.1 0.7 3.0 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Filament PF00038.16 ERZ95426.1 - 0.051 13.0 24.5 0.16 11.4 11.4 2.0 1 1 1 2 2 2 0 Intermediate filament protein Seryl_tRNA_N PF02403.17 ERZ95426.1 - 0.052 13.5 28.8 0.19 11.7 9.2 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.7 ERZ95426.1 - 0.057 13.1 30.1 0.056 13.1 17.2 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.5 ERZ95426.1 - 0.064 13.3 17.8 0.039 14.0 7.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3584 PF12128.3 ERZ95426.1 - 0.089 10.1 21.7 0.097 9.9 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF972 PF06156.8 ERZ95426.1 - 0.11 12.8 25.9 0.43 10.9 4.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF3552 PF12072.3 ERZ95426.1 - 0.15 11.2 33.6 0.15 11.2 14.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) LPP PF04728.8 ERZ95426.1 - 0.15 11.8 0.8 12 5.7 0.1 2.4 1 1 1 2 2 2 0 Lipoprotein leucine-zipper IFT57 PF10498.4 ERZ95426.1 - 0.23 10.1 21.8 0.28 9.8 15.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Cortex-I_coil PF09304.5 ERZ95426.1 - 0.29 11.1 29.3 0.061 13.3 14.3 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil CASP_C PF08172.7 ERZ95426.1 - 0.33 9.9 24.6 0.81 8.6 1.3 2.9 1 1 1 2 2 2 0 CASP C terminal YjcZ PF13990.1 ERZ95426.1 - 0.37 9.8 8.7 0.52 9.3 5.7 1.4 1 1 0 1 1 1 0 YjcZ-like protein CENP-Q PF13094.1 ERZ95426.1 - 0.4 10.6 32.1 0.53 10.3 19.4 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit HOOK PF05622.7 ERZ95426.1 - 0.54 7.9 25.0 0.71 7.6 17.3 1.2 1 0 0 1 1 1 0 HOOK protein AAA_13 PF13166.1 ERZ95426.1 - 0.63 8.4 26.5 0.15 10.4 8.4 1.8 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.7 ERZ95426.1 - 0.64 9.8 15.1 0.32 10.7 7.0 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) PspA_IM30 PF04012.7 ERZ95426.1 - 0.66 9.2 23.7 13 5.1 15.9 2.3 1 1 0 1 1 1 0 PspA/IM30 family APG6 PF04111.7 ERZ95426.1 - 0.76 8.7 32.3 2 7.4 22.4 1.6 1 1 0 1 1 1 0 Autophagy protein Apg6 DUF812 PF05667.6 ERZ95426.1 - 0.82 8.1 25.9 0.89 7.9 17.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TBPIP PF07106.8 ERZ95426.1 - 0.98 8.9 29.1 47 3.4 20.2 2.1 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4164 PF13747.1 ERZ95426.1 - 0.98 9.5 22.7 0.36 10.9 6.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) BLOC1_2 PF10046.4 ERZ95426.1 - 1 9.5 21.6 5.4e+02 0.8 14.9 2.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMCO5 PF14992.1 ERZ95426.1 - 1.2 8.1 27.9 1.3 8.0 19.3 1.1 1 0 0 1 1 1 0 TMCO5 family Rootletin PF15035.1 ERZ95426.1 - 1.2 9.0 26.7 0.098 12.6 1.6 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Tektin PF03148.9 ERZ95426.1 - 1.3 7.4 22.8 0.57 8.6 2.2 2.2 1 1 1 2 2 2 0 Tektin family V_ATPase_I PF01496.14 ERZ95426.1 - 1.4 6.7 20.1 1.7 6.3 13.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3086 PF11285.3 ERZ95426.1 - 1.4 7.6 13.8 1.8 7.2 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) DUF4140 PF13600.1 ERZ95426.1 - 1.7 9.1 20.4 0.68 10.4 2.4 2.9 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2968 PF11180.3 ERZ95426.1 - 1.8 7.9 14.9 0.2 11.0 2.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) AHS1 PF02682.11 ERZ95426.1 - 1.8 7.9 3.8 1.9 7.8 2.1 1.4 1 1 0 1 1 1 0 Allophanate hydrolase subunit 1 Baculo_PEP_C PF04513.7 ERZ95426.1 - 2.1 8.1 7.3 19 5.0 5.0 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.8 ERZ95426.1 - 2.4 7.1 16.7 3.4 6.6 11.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein Mod_r PF07200.8 ERZ95426.1 - 2.5 8.0 26.4 4.3 7.2 18.3 1.6 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Cluap1 PF10234.4 ERZ95426.1 - 2.7 7.1 24.5 8.6 5.4 17.0 1.6 1 1 0 1 1 1 0 Clusterin-associated protein-1 Med4 PF10018.4 ERZ95426.1 - 2.8 7.3 22.4 1.2 8.4 6.1 2.2 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4200 PF13863.1 ERZ95426.1 - 2.8 7.8 35.2 11 5.9 23.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin PF00804.20 ERZ95426.1 - 2.9 8.1 24.7 1.7 8.8 11.0 2.1 1 1 1 2 2 2 0 Syntaxin SlyX PF04102.7 ERZ95426.1 - 3 8.2 19.5 0.51 10.7 3.5 2.7 1 1 2 3 3 3 0 SlyX CALCOCO1 PF07888.6 ERZ95426.1 - 3 6.0 22.1 3.8 5.6 15.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.7 ERZ95426.1 - 3.1 8.1 11.1 35 4.7 4.5 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.3 ERZ95426.1 - 3.1 7.5 32.2 0.49 10.1 10.3 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.3 ERZ95426.1 - 3.3 6.8 18.3 24 4.1 12.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Ax_dynein_light PF10211.4 ERZ95426.1 - 3.4 7.4 29.7 2 8.2 8.5 2.3 1 1 1 2 2 2 0 Axonemal dynein light chain Nsp1_C PF05064.8 ERZ95426.1 - 3.6 7.2 17.7 9.5 5.8 2.3 1.9 1 1 1 2 2 2 0 Nsp1-like C-terminal region Fzo_mitofusin PF04799.8 ERZ95426.1 - 4.2 6.7 19.0 5.7 6.2 6.3 2.3 1 1 1 2 2 2 0 fzo-like conserved region DUF4559 PF15112.1 ERZ95426.1 - 4.3 6.4 15.6 6.2 5.8 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF4404 PF14357.1 ERZ95426.1 - 4.5 7.7 23.3 0.56 10.6 8.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) RmuC PF02646.11 ERZ95426.1 - 4.9 5.9 17.5 2.1 7.1 6.5 2.5 1 1 2 3 3 3 0 RmuC family Syntaxin-6_N PF09177.6 ERZ95426.1 - 5.1 7.5 17.8 17 5.8 4.2 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HemX PF04375.9 ERZ95426.1 - 5.1 5.5 18.5 1.8 7.0 4.5 2.0 1 1 1 2 2 2 0 HemX COG2 PF06148.6 ERZ95426.1 - 5.6 6.8 19.5 4.6 7.1 2.7 2.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Uds1 PF15456.1 ERZ95426.1 - 5.6 6.9 23.5 2 8.4 6.8 2.5 1 1 1 2 2 2 0 Up-regulated During Septation DUF724 PF05266.9 ERZ95426.1 - 5.9 6.4 26.6 13 5.3 17.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FimP PF09766.4 ERZ95426.1 - 6 5.8 22.4 9.8 5.1 5.2 2.1 1 1 1 2 2 2 0 Fms-interacting protein LMBR1 PF04791.11 ERZ95426.1 - 6.1 5.3 13.8 1.6 7.2 7.4 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein YscO PF07321.7 ERZ95426.1 - 6.3 6.6 29.5 17 5.1 16.7 2.1 1 1 1 2 2 2 0 Type III secretion protein YscO Lectin_N PF03954.9 ERZ95426.1 - 6.7 6.1 13.1 0.5 9.7 3.7 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DivIC PF04977.10 ERZ95426.1 - 6.9 6.2 28.4 0.48 9.9 2.3 3.6 1 1 2 3 3 2 0 Septum formation initiator Exonuc_VII_L PF02601.10 ERZ95426.1 - 7.2 5.6 19.5 8.1 5.5 13.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SYCE1 PF15233.1 ERZ95426.1 - 7.4 6.5 27.3 10 6.0 18.9 1.4 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 Snapin_Pallidin PF14712.1 ERZ95426.1 - 8.1 6.8 19.3 14 6.1 4.7 3.0 1 1 1 2 2 2 0 Snapin/Pallidin Spectrin PF00435.16 ERZ95426.1 - 8.1 6.7 22.9 4.7 7.5 5.9 2.2 1 1 1 2 2 2 0 Spectrin repeat CDC37_N PF03234.9 ERZ95426.1 - 8.4 6.6 21.6 27 5.0 15.0 1.8 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding HisKA_3 PF07730.8 ERZ95426.1 - 8.4 6.8 7.1 8.5 6.8 2.0 2.7 1 1 1 2 2 2 0 Histidine kinase FlaC_arch PF05377.6 ERZ95426.1 - 9.3 6.2 26.1 3.7 7.5 2.2 3.8 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF673 PF05054.7 ERZ95427.1 - 0.03 12.9 0.3 0.041 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF673) Phi-29_GP16_7 PF06720.6 ERZ95427.1 - 0.054 13.1 0.1 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 AHSP PF09236.5 ERZ95428.1 - 0.028 14.6 0.1 0.045 13.9 0.1 1.3 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein GH-E PF14410.1 ERZ95428.1 - 0.045 13.8 3.5 0.049 13.7 0.8 2.1 2 1 0 2 2 2 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues MULE PF10551.4 ERZ95429.1 - 0.051 13.7 0.1 0.1 12.7 0.0 1.5 2 0 0 2 2 2 0 MULE transposase domain Band_7 PF01145.20 ERZ95430.1 - 1e-29 103.7 0.2 1.6e-29 103.0 0.2 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 ERZ95430.1 - 0.038 13.4 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family DivIVA PF05103.8 ERZ95430.1 - 3.7 7.5 9.8 2.3e+02 1.8 6.8 2.5 1 1 0 1 1 1 0 DivIVA protein DUF676 PF05057.9 ERZ95431.1 - 7.7e-50 169.2 0.0 9.2e-50 168.9 0.0 1.0 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 ERZ95431.1 - 1.8e-06 27.7 0.0 2.1e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 ERZ95431.1 - 9.6e-05 22.0 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 ERZ95431.1 - 0.00011 21.8 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.2 ERZ95431.1 - 0.00084 19.2 0.0 0.0024 17.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF4049 PF13258.1 ERZ95431.1 - 0.0027 16.7 0.1 0.086 11.7 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4049) DLH PF01738.13 ERZ95431.1 - 0.019 14.2 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 ERZ95431.1 - 0.087 12.3 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ins145_P3_rec PF08709.6 ERZ95433.1 - 0.00019 20.5 0.1 0.0021 17.1 0.0 2.1 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ERZ95433.1 - 0.00038 20.0 0.0 0.057 12.9 0.0 2.2 1 1 1 2 2 2 2 MIR domain SAP PF02037.22 ERZ95434.1 - 0.15 11.5 0.8 0.45 10.0 0.0 2.2 2 0 0 2 2 2 0 SAP domain PRP21_like_P PF12230.3 ERZ95436.1 - 0.028 13.9 0.0 0.034 13.6 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein RRM_6 PF14259.1 ERZ95437.1 - 0.072 13.0 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF1227 PF06777.6 ERZ95438.1 - 0.021 14.5 0.0 0.025 14.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1227) BTB PF00651.26 ERZ95439.1 - 3.4e-11 43.1 0.1 6e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ95439.1 - 3.4e-09 36.8 1.3 3.4e-09 36.8 0.9 1.8 2 0 0 2 2 2 1 TLD KH_3 PF13014.1 ERZ95439.1 - 8.1e-05 22.1 0.0 0.00044 19.8 0.0 2.2 2 0 0 2 2 2 1 KH domain KH_1 PF00013.24 ERZ95439.1 - 0.00022 20.8 0.0 0.00059 19.4 0.0 1.8 2 0 0 2 2 2 1 KH domain BACK PF07707.10 ERZ95439.1 - 0.00029 20.6 2.5 0.00083 19.1 0.7 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ95440.1 - 1.7e-11 44.2 1.7 1.7e-11 44.2 1.2 2.0 3 0 0 3 3 3 1 TLD BTB PF00651.26 ERZ95440.1 - 2.7e-11 43.4 0.0 5.8e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ95440.1 - 0.0057 16.4 1.8 0.022 14.6 0.5 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch FAR1 PF03101.10 ERZ95441.1 - 0.00033 21.1 2.4 0.0046 17.4 0.3 2.4 1 1 1 2 2 2 2 FAR1 DNA-binding domain TLD PF07534.11 ERZ95443.1 - 3.1e-11 43.4 1.3 3.5e-11 43.2 0.9 1.1 1 0 0 1 1 1 1 TLD Serglycin PF04360.7 ERZ95445.1 - 0.018 14.7 0.8 0.019 14.6 0.6 1.1 1 0 0 1 1 1 0 Serglycin SEEEED PF14797.1 ERZ95445.1 - 0.025 14.7 11.5 0.027 14.5 7.9 1.0 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Adap_comp_sub PF00928.16 ERZ95447.1 - 1.4e-68 230.8 0.0 1.7e-68 230.5 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ERZ95447.1 - 3.2e-11 43.1 0.0 5.8e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Dsl1_N PF11988.3 ERZ95447.1 - 0.0088 14.9 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 N terminal 4F5 PF04419.9 ERZ95448.1 - 1.7e-08 35.0 12.2 1.7e-08 35.0 8.5 2.3 2 1 0 2 2 2 1 4F5 protein family Bac_small_YrzI PF09501.5 ERZ95448.1 - 4.4 7.2 9.2 0.43 10.5 1.5 2.1 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) Pkinase_Tyr PF07714.12 ERZ95449.1 - 7.9e-47 159.4 0.0 2.2e-42 144.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95449.1 - 9.1e-40 136.4 0.2 9.1e-33 113.5 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain YrbL-PhoP_reg PF10707.4 ERZ95449.1 - 3.4e-05 23.2 0.2 8.4e-05 21.9 0.1 1.7 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ95449.1 - 0.0015 17.6 0.2 0.0026 16.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ95449.1 - 0.021 13.7 0.0 0.046 12.6 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Pkinase_Tyr PF07714.12 ERZ95450.1 - 2.7e-22 79.0 0.0 3e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95450.1 - 1.2e-19 70.4 0.0 1.3e-19 70.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF940 PF06082.6 ERZ95453.1 - 0.035 12.6 0.1 0.044 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Pkinase_Tyr PF07714.12 ERZ95456.1 - 8.3e-49 165.9 0.0 1.2e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95456.1 - 1e-47 162.5 1.3 1.2e-47 162.3 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ERZ95456.1 - 3.4e-13 49.7 0.0 5.5e-07 30.0 0.1 3.3 3 0 0 3 3 3 2 Sel1 repeat YrbL-PhoP_reg PF10707.4 ERZ95456.1 - 0.00017 21.0 0.1 0.00035 19.9 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ERZ95456.1 - 0.0011 18.0 0.0 0.004 16.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ERZ95456.1 - 0.0012 18.2 0.6 0.0025 17.1 0.1 1.7 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ERZ95456.1 - 0.013 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95456.1 - 0.024 14.3 0.0 0.054 13.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family G10 PF01125.12 ERZ95456.1 - 0.034 13.6 3.1 0.068 12.7 0.2 2.4 2 0 0 2 2 2 0 G10 protein DUF1635 PF07795.6 ERZ95456.1 - 0.52 9.6 4.4 1.1 8.6 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF678 PF05077.7 ERZ95457.1 - 0.015 15.2 2.0 0.024 14.6 0.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF678) DUF581 PF04570.9 ERZ95457.1 - 0.038 13.2 0.1 0.13 11.5 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF581) MTBP_C PF14920.1 ERZ95457.1 - 1.1 8.7 5.1 1.3 8.4 2.9 1.4 1 1 0 2 2 2 0 MDM2-binding PI3_PI4_kinase PF00454.22 ERZ95459.1 - 2e-51 174.7 0.1 6.6e-51 173.0 0.1 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 ERZ95459.1 - 0.00048 20.1 14.1 0.0045 17.0 0.0 6.7 7 1 1 8 8 8 2 Rapamycin binding domain DUF2802 PF10975.3 ERZ95459.1 - 0.79 9.5 5.1 0.28 10.9 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) Pkinase PF00069.20 ERZ95461.1 - 0.037 13.1 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Cu-binding_MopE PF11617.3 ERZ95461.1 - 0.067 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein metal binding site Pkinase_Tyr PF07714.12 ERZ95461.1 - 0.069 12.2 0.0 0.087 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Uso1_p115_head PF04869.9 ERZ95461.1 - 0.11 11.2 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region Pkinase PF00069.20 ERZ95462.1 - 2e-28 99.2 0.0 6.9e-28 97.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95462.1 - 1.3e-27 96.5 0.0 8.2e-27 93.8 0.0 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase WaaY PF06176.6 ERZ95462.1 - 0.023 13.9 0.0 0.038 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ERZ95462.1 - 0.054 13.2 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Apc9 PF12856.2 ERZ95462.1 - 0.83 9.7 4.9 0.45 10.6 1.2 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 9 Xpo1 PF08389.7 ERZ95463.1 - 6.2e-38 130.0 3.7 1.7e-37 128.6 1.7 2.5 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.14 ERZ95463.1 - 0.001 18.9 0.0 0.0042 16.9 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 ERZ95463.1 - 0.0085 16.5 0.6 6.1 7.4 0.0 3.9 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 ERZ95463.1 - 0.75 10.0 4.8 32 4.9 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat UPF0020 PF01170.13 ERZ95464.1 - 8.2e-14 51.5 0.0 1.5e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 ERZ95464.1 - 1.1e-10 41.5 0.0 2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 ERZ95464.1 - 2.9e-05 23.3 0.0 5.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.13 ERZ95464.1 - 0.024 14.1 0.1 3.9 6.8 0.0 2.5 2 1 0 2 2 2 0 DNA methylase Peptidase_C14 PF00656.17 ERZ95465.1 - 8e-64 215.7 0.0 2.2e-63 214.2 0.0 1.7 1 1 0 1 1 1 1 Caspase domain Raptor_N PF14538.1 ERZ95465.1 - 0.048 13.4 0.9 17 5.2 0.0 3.3 3 1 0 3 3 3 0 Raptor N-terminal CASPase like domain FAR1 PF03101.10 ERZ95466.1 - 0.00054 20.4 1.7 0.00079 19.9 1.2 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain U3_assoc_6 PF08640.6 ERZ95468.1 - 0.022 14.4 0.4 0.55 10.0 0.1 2.4 1 1 1 2 2 2 0 U3 small nucleolar RNA-associated protein 6 MOZ_SAS PF01853.13 ERZ95469.1 - 2e-89 297.8 0.7 2.9e-89 297.2 0.5 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 ERZ95469.1 - 5.6e-22 77.1 1.2 5.6e-22 77.1 0.8 1.8 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.1 ERZ95469.1 - 0.023 14.8 0.0 0.062 13.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 ERZ95469.1 - 0.042 13.6 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein zf-C2H2_4 PF13894.1 ERZ95469.1 - 0.5 10.8 3.8 1.5 9.3 2.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger Toluene_X PF03349.11 ERZ95470.1 - 0.011 14.1 3.8 0.013 13.9 2.6 1.1 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) CDC48_N PF02359.13 ERZ95472.1 - 9.3e-06 25.5 0.1 0.0072 16.2 0.0 2.2 2 0 0 2 2 2 2 Cell division protein 48 (CDC48), N-terminal domain Molydop_binding PF01568.16 ERZ95472.1 - 0.0036 17.0 0.0 0.0046 16.7 0.0 1.1 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain AAA PF00004.24 ERZ95473.1 - 1e-90 300.7 0.1 9.7e-45 152.0 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ERZ95473.1 - 2.8e-17 62.5 0.0 1.7e-09 37.1 0.0 3.2 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ERZ95473.1 - 3.3e-13 49.8 0.0 6.6e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ERZ95473.1 - 8.3e-12 45.3 1.3 8.9e-05 22.6 0.2 5.1 4 2 0 4 4 3 2 AAA domain AAA_5 PF07728.9 ERZ95473.1 - 8.5e-12 44.9 0.3 5.9e-05 22.8 0.0 3.7 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ERZ95473.1 - 1.3e-11 44.8 0.0 3.1e-05 24.0 0.0 3.1 3 1 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 ERZ95473.1 - 2.2e-11 44.6 0.1 2.8e-06 28.1 0.0 3.1 2 1 0 2 2 2 2 AAA domain TIP49 PF06068.8 ERZ95473.1 - 1e-09 37.6 0.1 0.0018 17.0 0.0 2.9 2 1 1 3 3 3 2 TIP49 C-terminus AAA_14 PF13173.1 ERZ95473.1 - 3.1e-09 36.7 0.0 0.00017 21.4 0.0 3.1 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 ERZ95473.1 - 2e-07 30.6 0.0 0.0068 15.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.1 ERZ95473.1 - 7.5e-07 28.7 2.3 0.23 10.8 0.0 3.8 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.1 ERZ95473.1 - 1.4e-06 28.2 0.0 0.0016 18.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ERZ95473.1 - 1.9e-06 27.1 0.0 0.0036 16.4 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin RNA_helicase PF00910.17 ERZ95473.1 - 2e-06 27.9 0.0 0.14 12.3 0.0 3.4 3 0 0 3 3 3 2 RNA helicase Sigma54_activ_2 PF14532.1 ERZ95473.1 - 3.5e-06 27.1 0.0 0.018 15.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 ERZ95473.1 - 4e-06 26.1 0.4 0.044 12.9 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ERZ95473.1 - 8.3e-06 25.8 0.0 0.0092 15.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ERZ95473.1 - 9.8e-06 25.9 0.0 0.0017 18.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ERZ95473.1 - 1.1e-05 25.0 1.2 0.0052 16.5 0.2 3.6 3 0 0 3 3 3 1 Part of AAA domain KaiC PF06745.8 ERZ95473.1 - 8.4e-05 21.7 0.1 0.44 9.6 0.0 3.3 2 1 0 3 3 3 2 KaiC Sigma54_activat PF00158.21 ERZ95473.1 - 0.00015 21.3 0.5 0.39 10.1 0.0 4.6 3 2 0 3 3 3 1 Sigma-54 interaction domain ResIII PF04851.10 ERZ95473.1 - 0.00025 20.9 0.0 0.01 15.6 0.0 2.8 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_3 PF07726.6 ERZ95473.1 - 0.00043 19.9 0.0 0.81 9.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ERZ95473.1 - 0.00044 19.0 0.0 0.029 13.0 0.0 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_24 PF13479.1 ERZ95473.1 - 0.0029 17.2 1.1 0.4 10.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain IPT PF01745.11 ERZ95473.1 - 0.0034 16.6 0.2 0.19 10.8 0.1 2.3 2 0 0 2 2 2 1 Isopentenyl transferase Parvo_NS1 PF01057.12 ERZ95473.1 - 0.0036 16.2 0.1 0.23 10.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 PhoH PF02562.11 ERZ95473.1 - 0.0062 15.7 0.3 0.5 9.5 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.8 ERZ95473.1 - 0.0076 15.1 0.0 0.51 9.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 ERZ95473.1 - 0.012 15.3 0.4 1.1 8.9 0.0 3.5 3 1 0 3 3 2 0 Archaeal ATPase NACHT PF05729.7 ERZ95473.1 - 0.013 15.1 0.3 4.5 6.8 0.0 3.9 3 1 1 4 4 4 0 NACHT domain UPF0079 PF02367.12 ERZ95473.1 - 0.019 14.5 0.1 1.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ABC_tran PF00005.22 ERZ95473.1 - 0.024 14.9 0.0 1.7 8.9 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.1 ERZ95473.1 - 0.024 14.2 0.0 0.36 10.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.1 ERZ95473.1 - 0.025 14.5 0.0 7.6 6.3 0.0 2.9 2 1 1 3 3 3 0 Cytidylate kinase-like family SKI PF01202.17 ERZ95473.1 - 0.033 14.0 0.0 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase DUF2075 PF09848.4 ERZ95473.1 - 0.045 12.7 0.0 0.14 11.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Glutaredoxin PF00462.19 ERZ95473.1 - 0.064 13.2 0.1 21 5.1 0.0 3.0 2 1 1 3 3 2 0 Glutaredoxin T2SE PF00437.15 ERZ95473.1 - 0.065 12.1 0.0 2.6 6.8 0.0 2.5 3 0 0 3 3 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.20 ERZ95473.1 - 0.15 11.5 0.0 0.8 9.1 0.0 2.1 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 ERZ95473.1 - 0.35 10.5 3.3 11 5.6 0.0 4.2 4 1 1 5 5 4 0 NTPase CPSF_A PF03178.10 ERZ95474.1 - 3.7e-88 295.7 0.4 2.2e-86 289.8 0.0 3.2 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.4 ERZ95474.1 - 1e-28 99.7 1.6 1.6e-28 99.1 1.1 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Pkinase PF00069.20 ERZ95477.1 - 6.5e-09 35.3 0.0 1.2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ95477.1 - 2.1e-05 23.9 0.1 3.9e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ95477.1 - 0.00059 19.6 0.0 0.00081 19.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ95477.1 - 0.022 13.8 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Trypsin_2 PF13365.1 ERZ95478.1 - 0.034 14.1 0.0 0.084 12.8 0.0 1.7 1 1 0 1 1 1 0 Trypsin-like peptidase domain Abhydrolase_6 PF12697.2 ERZ95479.1 - 4.9e-25 88.7 0.0 6.8e-25 88.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ERZ95479.1 - 6.8e-11 42.1 0.0 1.6e-10 40.9 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ95479.1 - 2.3e-08 33.8 0.1 1.4e-06 28.0 0.1 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.8 ERZ95479.1 - 2.7e-05 23.7 0.0 4.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 ERZ95479.1 - 7.2e-05 22.1 0.0 0.15 11.3 0.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 ERZ95479.1 - 0.00041 19.8 0.0 0.072 12.5 0.0 3.0 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase DUF2305 PF10230.4 ERZ95479.1 - 0.00094 18.6 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) DUF915 PF06028.6 ERZ95479.1 - 0.0099 14.9 0.1 0.022 13.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Acyl_CoA_thio PF02551.10 ERZ95479.1 - 0.02 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA thioesterase PGAP1 PF07819.8 ERZ95479.1 - 0.033 13.7 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein LCAT PF02450.10 ERZ95479.1 - 0.072 12.0 0.1 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.8 ERZ95479.1 - 0.099 12.2 0.0 3.7 7.1 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase API5 PF05918.6 ERZ95481.1 - 5.4e-05 21.9 2.7 7.2e-05 21.4 1.9 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) GRP PF07172.6 ERZ95481.1 - 2.3 8.7 12.7 3.7 8.0 8.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family RAI16-like PF10257.4 ERZ95482.1 - 0.093 11.6 0.0 0.094 11.6 0.0 1.1 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein Pkinase_Tyr PF07714.12 ERZ95483.1 - 0.052 12.6 0.1 0.094 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ95486.1 - 0.00063 18.9 0.0 0.0016 17.5 0.0 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Stap_Strp_tox_C PF02876.12 ERZ95486.1 - 0.061 13.4 3.6 0.62 10.2 1.3 2.4 2 1 0 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain DUF867 PF05908.6 ERZ95487.1 - 0.22 10.6 2.0 0.25 10.4 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF867) 7kD_DNA_binding PF02294.13 ERZ95490.1 - 0.46 10.1 1.8 0.77 9.4 0.1 1.8 1 1 1 2 2 2 0 7kD DNA-binding domain AIG1 PF04548.11 ERZ95492.1 - 1.1e-54 184.8 0.1 5.1e-27 94.3 0.0 2.2 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.18 ERZ95492.1 - 5.4e-24 84.3 0.7 1.3e-10 41.2 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 ERZ95492.1 - 3.9e-14 52.1 0.0 4.2e-06 26.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 ERZ95492.1 - 1.2e-10 41.6 0.0 0.00074 19.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ERZ95492.1 - 1.5e-09 37.2 0.6 9.8e-05 21.5 0.1 2.7 2 0 0 2 2 2 2 Zeta toxin ABC_tran PF00005.22 ERZ95492.1 - 7.5e-09 36.0 3.8 0.0036 17.5 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SRPRB PF09439.5 ERZ95492.1 - 3.4e-08 32.9 0.2 0.0023 17.1 0.0 2.5 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_29 PF13555.1 ERZ95492.1 - 4.6e-08 32.4 0.2 0.0073 15.8 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.18 ERZ95492.1 - 6e-08 32.6 14.3 0.031 14.1 0.0 5.1 4 1 1 5 5 4 3 Dynamin family AAA_18 PF13238.1 ERZ95492.1 - 2.5e-07 31.0 15.1 0.003 17.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain RNA_helicase PF00910.17 ERZ95492.1 - 2.7e-07 30.7 0.0 0.0052 16.9 0.0 2.6 2 0 0 2 2 2 2 RNA helicase T2SE PF00437.15 ERZ95492.1 - 3.9e-07 29.2 0.0 0.0053 15.6 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein GTP_EFTU PF00009.22 ERZ95492.1 - 3.9e-07 29.6 0.1 0.011 15.1 0.0 3.2 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ERZ95492.1 - 4.4e-07 29.3 0.3 0.017 14.4 0.0 3.0 2 1 0 2 2 2 2 Ferrous iron transport protein B Gtr1_RagA PF04670.7 ERZ95492.1 - 7.7e-07 28.4 0.4 0.0017 17.5 0.0 3.1 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region Septin PF00735.13 ERZ95492.1 - 8.7e-07 28.2 5.4 0.0085 15.1 0.0 3.3 3 1 1 4 4 4 2 Septin AAA_16 PF13191.1 ERZ95492.1 - 9.3e-07 29.0 0.0 0.027 14.4 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 ERZ95492.1 - 3.5e-06 27.5 0.1 0.072 13.5 0.0 2.7 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 ERZ95492.1 - 4.8e-06 26.5 0.0 0.13 12.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ERZ95492.1 - 1.2e-05 26.1 13.1 0.26 12.1 2.1 4.5 2 2 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 ERZ95492.1 - 3.8e-05 23.2 0.0 0.23 10.9 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_10 PF12846.2 ERZ95492.1 - 0.0001 21.8 0.0 0.28 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA-like domain NB-ARC PF00931.17 ERZ95492.1 - 0.00013 20.9 0.0 0.027 13.3 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain DUF815 PF05673.8 ERZ95492.1 - 0.00024 20.1 0.3 0.27 10.1 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 ERZ95492.1 - 0.00038 20.0 0.0 0.89 8.9 0.0 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family MobB PF03205.9 ERZ95492.1 - 0.00048 19.8 0.8 1.2 8.8 0.0 2.7 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 ERZ95492.1 - 0.00058 19.5 0.8 3.6 7.3 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.9 ERZ95492.1 - 0.00082 18.4 1.2 0.28 10.1 0.2 2.9 2 2 0 2 2 2 1 KAP family P-loop domain UPF0079 PF02367.12 ERZ95492.1 - 0.0013 18.3 0.1 0.39 10.3 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_14 PF13173.1 ERZ95492.1 - 0.0014 18.4 0.2 2.5 7.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_PrkA PF08298.6 ERZ95492.1 - 0.0016 17.1 0.2 0.051 12.2 0.0 2.4 2 0 0 2 2 2 1 PrkA AAA domain AAA PF00004.24 ERZ95492.1 - 0.0026 17.9 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 ERZ95492.1 - 0.0027 17.2 0.8 2.2 7.6 0.0 2.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activ_2 PF14532.1 ERZ95492.1 - 0.0048 16.9 0.0 6.2 6.8 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain DUF2075 PF09848.4 ERZ95492.1 - 0.0054 15.7 1.2 1.5 7.7 0.0 3.1 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Arf PF00025.16 ERZ95492.1 - 0.0054 15.9 0.2 3.4 6.8 0.0 2.8 3 0 0 3 3 2 0 ADP-ribosylation factor family KaiC PF06745.8 ERZ95492.1 - 0.0063 15.6 0.1 1.1 8.3 0.0 2.5 2 0 0 2 2 2 1 KaiC SRP54 PF00448.17 ERZ95492.1 - 0.0069 15.8 3.0 3.9 6.8 0.3 3.7 3 1 1 4 4 4 0 SRP54-type protein, GTPase domain Guanylate_kin PF00625.16 ERZ95492.1 - 0.007 15.8 7.6 0.083 12.3 0.0 3.7 4 1 0 4 4 3 1 Guanylate kinase CPT PF07931.7 ERZ95492.1 - 0.0071 15.9 0.1 2.4 7.7 0.0 2.7 2 1 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein TrwB_AAD_bind PF10412.4 ERZ95492.1 - 0.0083 14.7 0.2 3.4 6.1 0.0 2.7 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.7 ERZ95492.1 - 0.0086 15.7 0.1 2.8 7.5 0.0 2.7 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.4 ERZ95492.1 - 0.012 15.0 8.4 2.1 7.8 0.8 3.8 2 2 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 ERZ95492.1 - 0.026 13.9 0.3 4 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.15 ERZ95492.1 - 0.032 13.8 0.1 6.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_30 PF13604.1 ERZ95492.1 - 0.035 13.6 0.1 3.8 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 ERZ95492.1 - 0.05 13.5 21.1 0.64 9.9 4.8 2.3 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.7 ERZ95492.1 - 0.089 12.0 0.2 5.1 6.3 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain ATP_bind_1 PF03029.12 ERZ95492.1 - 0.13 11.7 1.7 38 3.7 0.0 3.7 3 1 0 4 4 4 0 Conserved hypothetical ATP binding protein DUF3215 PF11503.3 ERZ95492.1 - 0.15 11.7 0.1 17 5.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3215) Sec2p PF06428.6 ERZ95492.1 - 0.33 10.8 9.3 5.5 6.9 2.5 2.6 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p PIN_2 PF10130.4 ERZ95492.1 - 1.3 9.0 5.8 4.8 7.2 4.1 1.9 1 1 0 1 1 1 0 PIN domain AAA_23 PF13476.1 ERZ95492.1 - 2.9 8.1 40.6 1 9.6 6.0 4.2 1 1 1 2 2 1 0 AAA domain Sel1 PF08238.7 ERZ95493.1 - 1.7e-199 641.9 124.1 3.3e-13 49.8 0.3 21.2 19 2 1 20 20 20 20 Sel1 repeat TPR_6 PF13174.1 ERZ95493.1 - 2e-11 43.5 62.5 1.2 9.7 0.1 16.3 18 0 0 18 18 18 7 Tetratricopeptide repeat MIT PF04212.13 ERZ95493.1 - 7.6e-07 28.9 88.6 2.2 8.2 0.1 17.4 14 3 1 15 15 15 9 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ95493.1 - 5.1e-06 26.2 63.1 7.4 7.0 0.1 17.2 16 2 1 18 18 18 6 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ERZ95493.1 - 0.018 14.7 38.4 54 3.6 0.0 13.6 16 0 0 16 16 16 0 Lung surfactant protein D coiled-coil trimerisation Collagen PF01391.13 ERZ95495.1 - 0.12 11.9 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) DUF3974 PF13120.1 ERZ95495.1 - 0.48 10.2 3.4 0.33 10.7 1.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3974) BTB PF00651.26 ERZ95496.1 - 4.5e-05 23.3 0.0 5.3e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Sel1 PF08238.7 ERZ95497.1 - 3.8e-11 43.2 4.3 5.4e-10 39.5 0.3 2.7 3 0 0 3 3 3 2 Sel1 repeat TPR_20 PF14561.1 ERZ95497.1 - 0.06 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TLD PF07534.11 ERZ95500.1 - 2.5e-20 72.8 0.6 2.5e-20 72.8 0.4 2.1 3 0 0 3 3 3 1 TLD BTB PF00651.26 ERZ95500.1 - 2.9e-18 65.8 0.1 5.6e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ95500.1 - 1e-08 34.9 3.4 2e-07 30.7 0.5 3.1 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ95501.1 - 0.025 14.5 0.1 0.035 14.1 0.1 1.2 1 0 0 1 1 1 0 BTB/POZ domain TLD PF07534.11 ERZ95502.1 - 4.7e-18 65.5 2.9 4.7e-18 65.5 2.0 2.3 2 0 0 2 2 2 1 TLD BTB PF00651.26 ERZ95502.1 - 1.5e-07 31.3 0.2 2.8e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ95502.1 - 6.2e-05 22.7 2.1 0.0062 16.3 0.6 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch Bacillus_HBL PF05791.6 ERZ95502.1 - 0.29 10.4 3.3 12 5.1 0.4 2.5 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) TLD PF07534.11 ERZ95503.1 - 1.1e-16 61.0 4.9 1.1e-16 61.0 3.4 2.1 2 0 0 2 2 2 1 TLD BTB PF00651.26 ERZ95503.1 - 9.2e-08 32.0 1.5 1.7e-07 31.2 0.3 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ95503.1 - 2e-06 27.5 2.0 0.00016 21.4 0.6 2.8 1 1 1 2 2 2 2 BTB And C-terminal Kelch DUF751 PF05421.6 ERZ95504.1 - 0.31 11.3 4.6 1.8 8.8 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF751) Pkinase_Tyr PF07714.12 ERZ95505.1 - 0.065 12.3 0.0 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ95506.1 - 3.2e-34 118.1 0.0 1.4e-32 112.8 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95506.1 - 7.7e-34 117.0 0.7 1.7e-30 106.0 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ERZ95506.1 - 0.14 11.8 0.8 0.22 11.2 0.5 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF962 PF06127.6 ERZ95507.1 - 3.4e-23 81.3 0.1 6.2e-23 80.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF4234 PF14018.1 ERZ95507.1 - 1 9.1 5.3 0.21 11.3 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) FlxA PF14282.1 ERZ95508.1 - 0.045 13.6 32.1 0.46 10.4 2.6 4.7 2 1 3 5 5 5 0 FlxA-like protein SUKH-3 PF14433.1 ERZ95508.1 - 0.059 13.1 0.5 0.23 11.2 0.1 2.1 1 1 1 2 2 2 0 SUKH-3 immunity protein NPV_P10 PF05531.7 ERZ95508.1 - 0.095 12.9 3.7 0.99 9.6 0.1 3.7 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 ERZ95508.1 - 4.1 7.3 9.3 5.3 7.0 0.1 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) PK PF00224.16 ERZ95509.1 - 7.1e-166 551.0 2.5 8.7e-166 550.7 1.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 ERZ95509.1 - 1.9e-32 111.2 0.0 4.1e-32 110.1 0.0 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 ERZ95509.1 - 0.00037 19.4 0.4 0.0012 17.8 0.2 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Cellulase PF00150.13 ERZ95509.1 - 0.05 12.8 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Ribosomal_L39 PF00832.15 ERZ95510.1 - 3.5e-22 77.5 10.5 4e-22 77.3 7.3 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Toxin_YhaV PF11663.3 ERZ95510.1 - 0.18 11.5 2.7 0.91 9.2 1.9 1.8 1 1 0 1 1 1 0 Toxin with endonuclease activity YhaV Pkinase PF00069.20 ERZ95511.1 - 3.9e-71 239.2 0.0 5.1e-71 238.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95511.1 - 2.1e-37 128.5 0.0 2.9e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.1 ERZ95511.1 - 1e-36 124.9 1.3 2.6e-36 123.6 0.6 2.0 1 1 0 1 1 1 1 PH domain Kinase-like PF14531.1 ERZ95511.1 - 5.6e-07 28.7 0.0 1.3e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ERZ95511.1 - 5.5e-05 22.3 0.0 0.00011 21.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95511.1 - 0.0035 17.1 0.0 0.01 15.6 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family She9_MDM33 PF05546.6 ERZ95512.1 - 2.7e-33 115.2 2.2 2.7e-33 115.2 1.5 1.4 1 1 0 1 1 1 1 She9 / Mdm33 family Ras_bdg_2 PF14847.1 ERZ95512.1 - 0.036 13.9 0.9 0.099 12.5 0.2 1.9 1 1 1 2 2 2 0 Ras-binding domain of Byr2 DUF3319 PF11782.3 ERZ95512.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) V-ATPase_G PF03179.10 ERZ95512.1 - 0.091 13.0 0.7 0.091 13.0 0.5 2.4 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit DUF4413 PF14372.1 ERZ95512.1 - 0.15 12.0 1.6 0.52 10.3 1.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4413) DUF4446 PF14584.1 ERZ95512.1 - 0.58 9.9 5.0 0.27 11.0 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Exonuc_VII_L PF02601.10 ERZ95512.1 - 2.3 7.3 6.7 3.1 6.8 4.6 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF1977 PF09320.6 ERZ95512.1 - 3.3 8.0 7.0 13 6.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1977) DUF465 PF04325.8 ERZ95512.1 - 3.5 7.4 7.8 5 6.9 0.1 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF465) DUF3552 PF12072.3 ERZ95512.1 - 3.6 6.7 9.1 0.2 10.8 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Dpy-30 PF05186.8 ERZ95513.1 - 1.5e-15 56.3 0.0 2.1e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Actin PF00022.14 ERZ95514.1 - 5.8e-51 173.1 0.0 9.5e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Actin DAP_epimerase PF01678.14 ERZ95514.1 - 0.094 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelate epimerase SAP PF02037.22 ERZ95515.1 - 0.00022 20.6 1.9 0.00039 19.8 1.3 1.5 1 0 0 1 1 1 1 SAP domain DNA_methylase PF00145.12 ERZ95515.1 - 0.0036 16.4 1.3 0.0046 16.1 0.9 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Ndc1_Nup PF09531.5 ERZ95515.1 - 0.0094 14.4 1.3 0.012 14.0 0.9 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup IDO PF01231.13 ERZ95516.1 - 1.3e-126 422.4 0.0 3.9e-125 417.6 0.0 2.0 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase Glyco_hydro_2_C PF02836.12 ERZ95516.1 - 0.019 13.8 0.1 1.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain CBM_14 PF01607.19 ERZ95516.1 - 0.11 12.4 0.3 0.26 11.2 0.2 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain COX17 PF05051.8 ERZ95516.1 - 0.24 11.4 0.4 0.48 10.4 0.3 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) DUF1115 PF06544.7 ERZ95517.1 - 6.2e-19 67.9 0.1 9.3e-19 67.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) p450 PF00067.17 ERZ95519.1 - 4.1e-40 137.6 0.0 4.5e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3453 PF11935.3 ERZ95519.1 - 0.0064 15.9 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) Acyltransferase PF01553.16 ERZ95521.1 - 1.5e-24 85.9 0.0 2.4e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Aa_trans PF01490.13 ERZ95523.1 - 6.2e-87 291.7 33.7 7.4e-87 291.4 23.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Nro1 PF12753.2 ERZ95523.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 SUI1 PF01253.17 ERZ95524.1 - 4.7e-29 100.0 1.2 6.1e-29 99.6 0.8 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2763 PF10961.3 ERZ95525.1 - 0.0024 18.2 0.1 0.0028 17.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2763) F-box PF00646.28 ERZ95526.1 - 0.00011 21.7 0.0 0.00043 19.8 0.0 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ERZ95526.1 - 0.00023 20.7 0.1 0.00079 19.0 0.0 1.9 1 0 0 1 1 1 1 F-box-like DltD_M PF04918.7 ERZ95526.1 - 0.0018 18.5 0.6 0.0032 17.6 0.4 1.4 1 0 0 1 1 1 1 DltD central region PRELI PF04707.9 ERZ95526.1 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 PRELI-like family MPC PF03650.8 ERZ95527.1 - 4.4e-39 133.1 0.2 5e-39 132.9 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) EamA PF00892.15 ERZ95528.1 - 5.2e-09 36.2 26.4 2e-05 24.6 2.5 2.6 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.10 ERZ95528.1 - 2.3e-08 33.4 0.2 2.3e-08 33.4 0.1 2.1 2 0 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.6 ERZ95528.1 - 1.2e-07 30.9 10.8 1.9e-07 30.2 7.5 1.3 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 ERZ95528.1 - 0.00025 20.7 21.0 0.0025 17.4 8.7 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family BTB PF00651.26 ERZ95529.1 - 9.3e-06 25.6 0.0 1.4e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 BTB/POZ domain SIS PF01380.17 ERZ95529.1 - 0.078 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 SIS domain DUF643 PF04867.7 ERZ95530.1 - 0.019 15.3 1.3 0.021 15.1 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF643) PhnA_Zn_Ribbon PF08274.7 ERZ95530.1 - 0.16 11.7 0.7 0.24 11.2 0.5 1.3 1 0 0 1 1 1 0 PhnA Zinc-Ribbon CCDC32 PF14989.1 ERZ95531.1 - 0.066 13.0 0.6 0.085 12.6 0.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing 32 HMG_box_2 PF09011.5 ERZ95532.1 - 5.2e-07 29.9 2.0 7.7e-07 29.4 1.4 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ERZ95532.1 - 4.9e-05 23.5 3.1 0.00012 22.2 2.1 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box RdRP PF05183.7 ERZ95533.1 - 5.6e-127 424.8 3.9 6.4e-126 421.3 2.7 1.9 1 1 0 1 1 1 1 RNA dependent RNA polymerase RdRP PF05183.7 ERZ95534.1 - 3e-118 396.0 0.1 3.6e-118 395.7 0.1 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase RdRP PF05183.7 ERZ95535.1 - 1e-42 146.6 3.6 7.1e-11 41.5 0.1 4.4 2 1 1 4 4 4 4 RNA dependent RNA polymerase Alpha_kinase PF02816.13 ERZ95535.1 - 2.8e-05 23.8 1.7 5.9e-05 22.8 0.2 2.2 2 0 0 2 2 2 1 Alpha-kinase family RdRP PF05183.7 ERZ95536.1 - 4.4e-134 448.3 0.2 5.9e-134 447.9 0.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pkinase_Tyr PF07714.12 ERZ95537.1 - 3e-16 59.2 0.0 5.6e-15 55.1 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95537.1 - 2.1e-10 40.1 0.0 9e-10 38.1 0.0 1.8 1 1 0 2 2 2 1 Protein kinase domain TPD PF14811.1 ERZ95538.1 - 0.12 11.8 1.3 0.2 11.2 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function TPD sequence-motif DUF3417 PF11897.3 ERZ95540.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3417) Pkinase_Tyr PF07714.12 ERZ95540.1 - 0.054 12.5 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ95542.1 - 0.0036 16.4 0.0 0.0042 16.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95542.1 - 0.073 12.2 0.0 0.08 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Mononeg_RNA_pol PF00946.14 ERZ95542.1 - 0.091 10.1 0.1 0.1 9.9 0.1 1.0 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase GST_C PF00043.20 ERZ95543.1 - 3e-15 55.9 0.1 1.4e-14 53.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ERZ95543.1 - 2.5e-14 53.2 0.0 4.2e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ERZ95543.1 - 1.1e-12 47.9 0.0 2.3e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ERZ95543.1 - 3.4e-12 46.1 0.0 7.4e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ERZ95543.1 - 8.6e-10 38.3 0.0 1.6e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ERZ95543.1 - 3.9e-08 33.6 0.0 9.6e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ABC_membrane_2 PF06472.10 ERZ95544.1 - 2.2e-61 207.4 6.6 3.5e-61 206.8 4.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ERZ95544.1 - 7.4e-18 65.1 0.0 1.5e-17 64.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ERZ95544.1 - 2.2e-05 23.8 2.6 0.0081 15.4 0.7 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ERZ95544.1 - 0.0017 18.3 0.0 0.0017 18.3 0.0 4.1 3 2 0 5 5 5 1 AAA domain DUF3584 PF12128.3 ERZ95544.1 - 0.0041 14.5 0.0 0.0062 13.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_23 PF13476.1 ERZ95544.1 - 0.0051 17.1 0.1 0.0051 17.1 0.0 2.8 3 1 1 4 4 4 1 AAA domain AAA_16 PF13191.1 ERZ95544.1 - 0.0055 16.7 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 ERZ95544.1 - 0.008 15.6 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.7 ERZ95544.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain T2SE PF00437.15 ERZ95544.1 - 0.016 14.1 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.12 ERZ95544.1 - 0.019 14.3 0.1 0.11 11.9 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein Glycos_transf_4 PF00953.16 ERZ95544.1 - 0.022 14.5 2.8 0.039 13.7 0.6 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 4 Arch_ATPase PF01637.13 ERZ95544.1 - 0.052 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 ERZ95544.1 - 0.098 12.0 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain AAA_25 PF13481.1 ERZ95544.1 - 0.11 11.8 0.0 0.41 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 ERZ95544.1 - 0.14 12.6 0.0 0.38 11.2 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Mg_chelatase PF01078.16 ERZ95544.1 - 0.17 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 ERZ95544.1 - 0.27 10.7 0.0 0.47 10.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rubredoxin PF00301.15 ERZ95546.1 - 0.0074 16.1 0.4 0.036 13.9 0.1 2.3 2 0 0 2 2 2 1 Rubredoxin DUF2225 PF09986.4 ERZ95546.1 - 0.0092 15.4 1.8 0.025 14.0 1.1 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) PWI PF01480.12 ERZ95546.1 - 0.023 14.7 0.6 0.023 14.7 0.4 2.1 2 0 0 2 2 2 0 PWI domain STAT_int PF02865.12 ERZ95546.1 - 0.062 13.2 3.7 0.041 13.8 1.1 1.7 2 0 0 2 2 2 0 STAT protein, protein interaction domain zf-CCHC PF00098.18 ERZ95548.1 - 0.028 14.3 4.7 0.05 13.5 3.2 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.1 ERZ95548.1 - 0.12 12.1 3.6 0.26 11.0 2.5 1.5 1 0 0 1 1 1 0 Zinc knuckle Pkinase_Tyr PF07714.12 ERZ95551.1 - 4.4e-47 160.3 0.0 6.6e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95551.1 - 4e-46 157.2 1.1 9.9e-46 155.9 0.0 2.1 2 1 0 3 3 3 1 Protein kinase domain Sel1 PF08238.7 ERZ95551.1 - 1.5e-25 89.0 8.7 5.1e-08 33.3 0.5 4.9 5 0 0 5 5 5 4 Sel1 repeat Kinase-like PF14531.1 ERZ95551.1 - 9.6e-05 21.4 0.0 0.013 14.4 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ERZ95551.1 - 0.002 17.2 0.0 0.0041 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ95551.1 - 0.002 17.4 0.3 0.0067 15.7 0.0 2.1 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ERZ95551.1 - 0.0095 15.6 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF2573 PF10835.3 ERZ95551.1 - 0.037 14.0 2.7 0.042 13.9 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2573) HMG_box PF00505.14 ERZ95553.1 - 9.1e-09 35.4 1.0 2.7e-08 33.9 0.7 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ95553.1 - 0.00071 19.8 2.6 0.0008 19.7 0.4 2.1 1 1 1 2 2 2 1 HMG-box domain Pkinase PF00069.20 ERZ95555.1 - 5.7e-16 58.4 2.3 1.5e-08 34.1 1.2 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95555.1 - 1.9e-15 56.6 2.0 1.4e-08 34.1 0.5 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ERZ95555.1 - 2e-05 23.7 0.1 2e-05 23.7 0.1 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ95555.1 - 6e-05 22.4 0.2 8e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ95555.1 - 0.038 12.9 0.1 0.064 12.2 0.1 1.4 1 1 0 1 1 1 0 Kinase-like Choline_kinase PF01633.15 ERZ95555.1 - 0.2 11.2 3.2 0.29 10.6 2.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase ig PF00047.20 ERZ95556.1 - 0.016 15.2 0.1 0.019 15.0 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin domain SURF6 PF04935.7 ERZ95557.1 - 0.15 11.3 1.5 0.16 11.2 1.1 1.0 1 0 0 1 1 1 0 Surfeit locus protein 6 Sel1 PF08238.7 ERZ95558.1 - 2.6e-35 120.0 10.3 2.5e-12 47.0 0.2 3.0 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ERZ95558.1 - 3.4e-06 27.1 4.0 0.034 14.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.13 ERZ95558.1 - 0.00027 20.7 8.4 0.37 10.6 0.1 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ERZ95558.1 - 0.0061 16.2 0.8 7.3 6.4 0.1 3.1 3 0 0 3 3 3 2 Lung surfactant protein D coiled-coil trimerisation TPR_12 PF13424.1 ERZ95558.1 - 0.053 13.4 7.6 0.59 10.1 3.3 3.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ95558.1 - 0.26 10.9 9.7 1.6 8.4 0.5 3.0 1 1 0 2 2 2 0 TPR repeat TPR_17 PF13431.1 ERZ95558.1 - 0.39 11.0 4.1 49 4.4 1.4 3.7 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ95558.1 - 3.1 7.9 16.1 8.5 6.5 0.2 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 ERZ95559.1 - 0.00047 19.0 0.0 0.00048 19.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Dimer_Tnp_hAT PF05699.9 ERZ95561.1 - 5.8e-07 29.0 0.0 1.3e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Yip1 PF04893.12 ERZ95562.1 - 1.6e-12 47.2 11.1 3.1e-12 46.3 7.7 1.5 1 1 0 1 1 1 1 Yip1 domain PKD_channel PF08016.7 ERZ95563.1 - 0.0097 14.3 15.8 0.18 10.2 0.7 2.3 1 1 1 2 2 2 2 Polycystin cation channel IncA PF04156.9 ERZ95563.1 - 0.012 15.2 1.0 0.26 10.8 0.4 2.9 2 1 0 2 2 2 0 IncA protein DDE_1 PF03184.14 ERZ95566.1 - 5.1e-18 65.0 0.0 8.1e-18 64.3 0.0 1.3 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ95566.1 - 0.00078 19.2 0.2 0.0013 18.5 0.2 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ95568.1 - 0.0094 15.1 0.1 0.013 14.6 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase_Tyr PF07714.12 ERZ95570.1 - 4.5e-15 55.4 0.0 7.7e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95570.1 - 1.6e-13 50.4 0.0 3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Spt4 PF06093.8 ERZ95570.1 - 0.044 13.6 0.5 0.044 13.6 0.4 4.5 4 1 1 5 5 5 0 Spt4/RpoE2 zinc finger GCC2_GCC3 PF07699.8 ERZ95570.1 - 4.3 7.0 19.7 0.35 10.4 0.5 4.5 4 0 0 4 4 4 0 GCC2 and GCC3 UQ_con PF00179.21 ERZ95571.1 - 6.7e-14 51.5 0.1 2.1e-13 49.9 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme F-box PF00646.28 ERZ95571.1 - 0.0022 17.6 0.0 0.0067 16.0 0.0 1.9 1 0 0 1 1 1 1 F-box domain RWD PF05773.17 ERZ95571.1 - 0.0024 17.7 0.1 0.0066 16.3 0.0 1.8 1 0 0 1 1 1 1 RWD domain UQ_con PF00179.21 ERZ95572.1 - 8.1e-14 51.2 0.1 1.8e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box PF00646.28 ERZ95572.1 - 0.0028 17.2 0.1 0.0084 15.7 0.1 1.9 1 0 0 1 1 1 1 F-box domain RWD PF05773.17 ERZ95572.1 - 0.0091 15.8 0.3 0.028 14.2 0.0 1.9 2 0 0 2 2 2 1 RWD domain UPF0066 PF01980.11 ERZ95572.1 - 0.13 12.1 0.1 0.38 10.7 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family UPF0066 HSP70 PF00012.15 ERZ95573.1 - 4.7e-06 24.8 0.0 2.8e-05 22.2 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95573.1 - 1.5e-05 23.7 0.0 0.069 11.7 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein MreB_Mbl PF06723.8 ERZ95574.1 - 0.018 13.6 0.1 0.25 9.8 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein HSP70 PF00012.15 ERZ95575.1 - 2.5e-05 22.4 0.1 0.00013 20.0 0.0 2.0 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95575.1 - 4.9e-05 22.0 0.0 0.21 10.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ95576.1 - 7.6e-09 34.0 0.0 2.5e-08 32.3 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95576.1 - 0.00011 20.9 0.0 0.062 11.8 0.0 2.3 1 1 0 1 1 1 1 MreB/Mbl protein HSP70 PF00012.15 ERZ95577.1 - 0.00011 20.2 0.0 0.00088 17.3 0.0 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95577.1 - 0.0088 14.6 0.0 2.3 6.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein BcrAD_BadFG PF01869.15 ERZ95577.1 - 0.2 10.8 0.0 0.34 10.1 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.15 ERZ95579.1 - 0.00041 18.4 0.1 0.0045 14.9 0.0 2.3 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95579.1 - 0.0054 15.3 0.0 0.69 8.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein LINES_N PF14694.1 ERZ95579.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Lines N-terminus HSP70 PF00012.15 ERZ95580.1 - 7.2e-05 20.8 0.2 0.00061 17.8 0.0 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95580.1 - 0.0026 16.4 0.0 1.5 7.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein EutH PF04346.7 ERZ95580.1 - 0.19 10.6 0.1 0.28 10.0 0.1 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein, EutH Pkinase_Tyr PF07714.12 ERZ95583.1 - 5.7e-44 150.1 0.5 2.7e-31 108.6 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95583.1 - 3.1e-41 141.2 2.5 1.3e-30 106.3 2.1 2.2 1 1 1 2 2 2 2 Protein kinase domain Sel1 PF08238.7 ERZ95583.1 - 4e-36 122.6 6.1 5.5e-08 33.1 0.0 6.2 6 0 0 6 6 6 4 Sel1 repeat RIO1 PF01163.17 ERZ95583.1 - 0.00011 21.5 0.6 0.00025 20.4 0.4 1.6 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ95583.1 - 0.00063 19.1 0.3 0.0014 18.0 0.2 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL MIT PF04212.13 ERZ95583.1 - 0.0031 17.3 4.5 1.7 8.5 0.4 3.9 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain Kdo PF06293.9 ERZ95583.1 - 0.0051 15.8 0.1 0.0087 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95583.1 - 0.02 14.6 0.1 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ95583.1 - 0.055 12.4 0.1 0.14 11.0 0.1 1.6 1 1 0 1 1 1 0 Kinase-like TPR_12 PF13424.1 ERZ95583.1 - 0.39 10.6 3.7 5.3 7.0 0.8 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Dimer_Tnp_hAT PF05699.9 ERZ95584.1 - 1.1e-20 73.0 0.7 1.2e-20 72.8 0.5 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ABC_tran_2 PF12848.2 ERZ95585.1 - 0.0042 16.8 0.0 0.0066 16.2 0.0 1.4 1 1 0 1 1 1 1 ABC transporter HSP70 PF00012.15 ERZ95586.1 - 2.8e-06 25.5 0.2 0.00015 19.8 0.0 3.2 3 1 0 3 3 3 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ95586.1 - 0.0016 17.1 0.0 0.12 10.9 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Peptidase_M22 PF00814.20 ERZ95586.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycoprotease family p450 PF00067.17 ERZ95587.1 - 2.8e-83 279.9 0.0 3.5e-83 279.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Chlor_dismutase PF06778.7 ERZ95588.1 - 0.089 12.4 0.1 0.09 12.4 0.0 1.0 1 0 0 1 1 1 0 Chlorite dismutase Dimer_Tnp_hAT PF05699.9 ERZ95589.1 - 1e-23 82.7 0.0 2.7e-23 81.3 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ERZ95589.1 - 0.034 14.1 0.4 0.074 13.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) ATP-synt_F6 PF05511.6 ERZ95589.1 - 0.052 13.4 0.3 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 Retrotrans_gag PF03732.12 ERZ95590.1 - 2.1e-07 30.9 0.1 7.4e-07 29.1 0.1 2.0 1 0 0 1 1 1 1 Retrotransposon gag protein UBN2 PF14223.1 ERZ95590.1 - 0.00011 21.9 0.5 0.0007 19.3 0.0 2.6 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type SSP160 PF06933.6 ERZ95590.1 - 2.7 5.8 9.2 4.4 5.1 6.4 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RTC4 PF14474.1 ERZ95592.1 - 1.8e-17 63.4 0.0 2.3e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 RTC4-like domain RVT_1 PF00078.22 ERZ95595.1 - 4e-09 36.1 0.1 4.2e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.12 ERZ95597.1 - 7.6e-50 169.3 0.0 2e-49 167.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95597.1 - 1.6e-41 142.1 0.0 3.4e-41 141.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ95597.1 - 0.0013 18.1 0.0 0.0036 16.6 0.0 1.7 1 0 0 1 1 1 1 RIO1 family MoeZ_MoeB PF05237.8 ERZ95599.1 - 0.0059 16.1 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 MoeZ/MoeB domain Nit_Regul_Hom PF10126.4 ERZ95600.1 - 0.037 13.7 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII Pkinase_Tyr PF07714.12 ERZ95601.1 - 7.5e-33 113.6 0.1 8.8e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95601.1 - 1.5e-24 86.5 0.1 1.8e-24 86.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ95601.1 - 8.4e-05 21.9 0.5 0.00012 21.4 0.3 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ95601.1 - 8.9e-05 21.6 0.1 0.00012 21.1 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ95601.1 - 0.0047 15.9 0.0 0.0059 15.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ERZ95601.1 - 0.06 12.6 0.1 0.077 12.3 0.1 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ERZ95601.1 - 0.069 12.8 0.0 0.12 12.0 0.0 1.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF2660 PF10859.3 ERZ95601.1 - 0.13 12.4 1.3 3 8.1 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2660) DNA_pol_B_2 PF03175.8 ERZ95602.1 - 4.1e-67 226.8 2.0 5.4e-67 226.4 1.4 1.1 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DNA_pol_B PF00136.16 ERZ95602.1 - 1.4e-05 24.0 0.0 0.02 13.6 0.0 3.0 3 0 0 3 3 3 2 DNA polymerase family B Pkinase_Tyr PF07714.12 ERZ95605.1 - 0.015 14.3 0.1 0.022 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase VitD-bind_III PF09164.5 ERZ95605.1 - 0.097 12.2 0.1 0.16 11.6 0.1 1.4 1 1 0 1 1 1 0 Vitamin D binding protein, domain III Bromodomain PF00439.20 ERZ95606.1 - 2.9e-16 59.1 0.0 3.2e-16 59.0 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.20 ERZ95608.1 - 3.1e-16 59.0 0.0 3.4e-16 58.9 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Sel1 PF08238.7 ERZ95609.1 - 6.6e-52 172.8 8.5 1.3e-12 47.8 0.5 6.2 6 0 0 6 6 6 6 Sel1 repeat Adeno_terminal PF02459.10 ERZ95609.1 - 0.066 11.3 0.5 0.22 9.6 0.1 1.9 1 1 1 2 2 2 0 Adenoviral DNA terminal protein TPR_6 PF13174.1 ERZ95609.1 - 0.094 13.2 5.8 8.1 7.1 0.3 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ERZ95609.1 - 0.17 11.8 16.0 6.6 6.6 0.1 5.3 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain F-box-like PF12937.2 ERZ95612.1 - 0.0033 17.1 0.1 0.045 13.4 0.0 2.8 2 0 0 2 2 2 1 F-box-like TAN PF11640.3 ERZ95612.1 - 0.012 15.3 0.8 0.21 11.3 0.0 2.8 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair F-box-like PF12937.2 ERZ95613.1 - 0.0035 17.0 0.9 0.011 15.4 0.2 2.1 2 0 0 2 2 2 1 F-box-like BTB PF00651.26 ERZ95614.1 - 0.0023 17.9 0.0 0.0025 17.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.20 ERZ95615.1 - 4.7e-17 62.0 0.0 7.3e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95615.1 - 1.2e-15 57.3 0.0 1.7e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TLD PF07534.11 ERZ95616.1 - 8.8e-10 38.7 8.4 6.9e-07 29.3 0.1 2.9 2 1 1 3 3 3 2 TLD BTB PF00651.26 ERZ95616.1 - 1.2e-08 34.9 2.7 2e-08 34.1 1.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ95616.1 - 0.00014 21.6 2.1 0.00014 21.6 1.4 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch T4_Gp59_N PF08993.5 ERZ95616.1 - 0.016 15.2 0.1 0.067 13.2 0.1 2.1 1 1 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase Pkinase_Tyr PF07714.12 ERZ95617.1 - 1.3e-30 106.3 4.1 8e-22 77.5 0.1 4.3 3 2 1 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.20 ERZ95617.1 - 5e-23 81.5 15.5 1.7e-21 76.5 2.5 4.2 3 1 1 4 4 4 2 Protein kinase domain BCS1_N PF08740.6 ERZ95617.1 - 2.6e-10 40.2 0.2 0.0076 15.8 0.0 3.3 3 0 0 3 3 3 3 BCS1 N terminal TrmB PF01978.14 ERZ95617.1 - 0.073 12.7 0.1 2.5 7.8 0.0 3.1 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB LRR_4 PF12799.2 ERZ95622.1 - 3.4e-09 36.1 0.3 0.016 14.7 0.0 4.6 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ95622.1 - 4.2e-09 36.0 1.0 0.0033 17.1 0.0 4.4 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 ERZ95622.1 - 4.3e-08 32.0 7.2 0.95 9.7 0.2 6.8 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_6 PF13516.1 ERZ95622.1 - 6.5e-06 25.6 9.7 1.6 9.0 0.2 6.6 7 0 0 7 7 7 2 Leucine Rich repeat F-box-like PF12937.2 ERZ95622.1 - 5.4e-05 22.8 0.0 0.00016 21.3 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_7 PF13504.1 ERZ95622.1 - 0.016 15.2 4.9 54 4.6 0.1 5.9 6 0 0 6 6 6 0 Leucine rich repeat TLD PF07534.11 ERZ95623.1 - 2.4e-13 50.2 1.8 4.7e-12 46.0 0.2 2.8 2 1 0 2 2 2 1 TLD BTB PF00651.26 ERZ95623.1 - 4.7e-11 42.6 0.0 1.9e-10 40.7 0.0 2.0 2 1 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ95623.1 - 0.0041 16.9 4.6 0.023 14.5 1.5 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch SET PF00856.23 ERZ95624.1 - 6.3e-10 39.5 0.3 1.2e-09 38.6 0.2 1.7 1 1 0 1 1 1 1 SET domain Ecl1 PF12855.2 ERZ95624.1 - 0.0025 17.0 1.0 0.0049 16.1 0.1 2.0 2 0 0 2 2 2 1 Life-span regulatory factor AMMECR1 PF01871.12 ERZ95625.1 - 1.2e-46 158.0 0.0 1.5e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 PIG-X PF08320.7 ERZ95626.1 - 6.2e-08 32.1 0.0 1.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 PIG-X / PBN1 DUF3350 PF11830.3 ERZ95626.1 - 0.15 12.1 0.2 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) GST_N_3 PF13417.1 ERZ95627.1 - 1.5e-12 47.5 0.0 4.4e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ERZ95627.1 - 0.00036 20.3 0.0 0.00053 19.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ERZ95627.1 - 0.00088 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ERZ95627.1 - 0.0048 16.8 0.0 0.0092 15.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain TPR_MLP1_2 PF07926.7 ERZ95628.1 - 0.017 14.8 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Cut8_C PF08559.5 ERZ95628.1 - 0.048 13.4 0.8 0.071 12.9 0.6 1.2 1 0 0 1 1 1 0 Cut8 six-helix bundle DUF3447 PF11929.3 ERZ95628.1 - 0.75 9.6 2.9 20 5.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Pkinase_Tyr PF07714.12 ERZ95629.1 - 2.6e-31 108.6 0.2 8.4e-31 106.9 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95629.1 - 3e-28 98.6 0.7 4e-28 98.2 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ95629.1 - 8e-14 51.7 8.9 2.6e-07 31.0 0.4 3.7 4 0 0 4 4 4 2 Sel1 repeat TPR_16 PF13432.1 ERZ95629.1 - 0.017 15.8 0.4 2.8 8.7 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ95629.1 - 0.26 10.9 5.0 4.1 7.1 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ95629.1 - 1.1 9.6 4.2 2.1 8.7 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ95629.1 - 1.8 9.2 5.0 26 5.5 0.7 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF972 PF06156.8 ERZ95630.1 - 0.087 13.1 1.1 0.16 12.2 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF502 PF04367.8 ERZ95630.1 - 0.13 12.0 0.1 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF502) OEP PF02321.13 ERZ95630.1 - 0.15 11.6 5.6 0.23 11.0 3.9 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein Sel1 PF08238.7 ERZ95631.1 - 1.2e-16 60.7 8.3 1.3e-06 28.8 0.7 3.8 3 1 0 3 3 3 3 Sel1 repeat Pkinase_Tyr PF07714.12 ERZ95631.1 - 2.5e-09 36.5 0.0 3.5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95631.1 - 1.2e-06 27.8 0.0 1.8e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TPR_16 PF13432.1 ERZ95631.1 - 0.0096 16.5 0.3 0.21 12.2 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ95631.1 - 0.023 15.0 0.9 0.48 10.7 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ95631.1 - 0.038 14.4 6.3 1.3 9.6 0.0 3.9 3 2 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.15 ERZ95631.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 PPR repeat TPR_14 PF13428.1 ERZ95631.1 - 0.2 12.4 0.7 1.8 9.3 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-CSL PF05207.8 ERZ95632.1 - 0.02 14.3 1.6 0.072 12.6 1.1 1.8 1 1 0 1 1 1 0 CSL zinc finger UPF0547 PF10571.4 ERZ95632.1 - 0.58 9.8 4.5 1.9 8.2 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Methyltransf_31 PF13847.1 ERZ95634.1 - 0.013 15.1 0.0 7.4 6.1 0.0 2.7 1 1 1 2 2 2 0 Methyltransferase domain Bromodomain PF00439.20 ERZ95634.1 - 0.026 14.4 2.3 0.4 10.6 0.0 3.2 4 0 0 4 4 4 0 Bromodomain DUF3846 PF12957.2 ERZ95635.1 - 0.001 18.7 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3846) CppA_C PF14507.1 ERZ95635.1 - 0.05 13.7 0.6 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 CppA C-terminal PH_4 PF15404.1 ERZ95638.1 - 0.068 12.6 0.3 0.13 11.8 0.2 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3409 PF11889.3 ERZ95638.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3409) Pkinase_Tyr PF07714.12 ERZ95639.1 - 9.9e-18 64.1 2.8 3.9e-14 52.3 0.0 4.6 4 2 1 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95639.1 - 1.5e-12 47.2 0.1 1.5e-12 47.2 0.1 3.4 3 2 2 5 5 5 1 Protein kinase domain PA14_2 PF10528.4 ERZ95639.1 - 0.012 15.5 4.9 1.8 8.5 0.1 3.5 3 0 0 3 3 3 0 GLEYA domain DUF4114 PF13448.1 ERZ95639.1 - 0.17 12.7 8.4 0.19 12.5 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4114) DnaJ_CXXCXGXG PF00684.14 ERZ95639.1 - 0.96 9.5 11.3 2.1 8.4 0.1 4.1 4 0 0 4 4 4 0 DnaJ central domain zf-H2C2_2 PF13465.1 ERZ95639.1 - 1.3 9.4 9.6 48 4.5 0.1 4.7 4 0 0 4 4 4 0 Zinc-finger double domain Pkinase_Tyr PF07714.12 ERZ95640.1 - 2.7e-26 92.2 0.0 3.9e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95640.1 - 5e-26 91.4 0.0 1.5e-25 89.7 0.0 1.6 1 1 1 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ERZ95644.1 - 3.4e-32 110.1 6.6 1.7e-10 41.2 0.0 4.0 4 0 0 4 4 4 4 Sel1 repeat TRL PF13146.1 ERZ95644.1 - 0.098 12.6 0.2 36 4.4 0.1 3.3 3 1 0 3 3 3 0 TRL-like protein family TPR_6 PF13174.1 ERZ95644.1 - 0.26 11.8 3.0 22 5.7 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat NUMOD1 PF07453.8 ERZ95644.1 - 1.5 8.7 7.2 2.4 8.1 0.1 3.2 4 1 0 4 4 4 0 NUMOD1 domain zf-CCHC PF00098.18 ERZ95645.1 - 0.12 12.3 1.2 0.21 11.6 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle Peptidase_M16_C PF05193.16 ERZ95649.1 - 3e-47 160.6 0.0 6.9e-47 159.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ERZ95649.1 - 1.9e-41 141.3 0.0 2.1e-40 137.8 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) FANCI_S2 PF14676.1 ERZ95649.1 - 0.22 11.4 1.8 0.57 10.0 0.2 2.1 2 0 0 2 2 2 0 FANCI solenoid 2 Lactamase_B_2 PF12706.2 ERZ95650.1 - 1.2e-12 47.8 0.2 1.6e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ERZ95650.1 - 2.7e-12 46.7 0.1 3.1e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BTB_2 PF02214.17 ERZ95653.1 - 6.6e-11 42.2 0.0 1.9e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Band_7 PF01145.20 ERZ95654.1 - 7.1e-15 55.3 1.4 7.1e-15 55.3 1.0 2.1 2 1 0 2 2 2 1 SPFH domain / Band 7 family Neisseria_TspB PF05616.8 ERZ95655.1 - 6.4 5.0 9.1 7 4.9 6.3 1.0 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PQQ PF01011.16 ERZ95657.1 - 2.1e-30 102.6 16.2 4.5e-06 25.9 0.0 7.8 7 1 0 7 7 7 6 PQQ enzyme repeat PQQ_2 PF13360.1 ERZ95657.1 - 5.5e-19 68.5 4.2 4e-08 33.0 0.0 4.5 1 1 2 3 3 3 3 PQQ-like domain PQQ_3 PF13570.1 ERZ95657.1 - 1.2e-16 60.3 19.4 1.2e-05 25.4 0.1 8.1 8 0 0 8 8 8 6 PQQ-like domain UDG PF03167.14 ERZ95658.1 - 6.5e-19 67.8 0.0 1e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Phage_AlpA PF05930.7 ERZ95658.1 - 0.081 12.6 0.1 1.3 8.8 0.0 2.5 3 0 0 3 3 3 0 Prophage CP4-57 regulatory protein (AlpA) DUF4061 PF13270.1 ERZ95659.1 - 0.015 15.3 0.9 0.039 14.0 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4061) DUF202 PF02656.10 ERZ95660.1 - 0.0072 16.5 1.9 0.0072 16.5 1.3 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF202) Claudin_2 PF13903.1 ERZ95660.1 - 0.045 13.4 0.1 0.051 13.2 0.1 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2721 PF11026.3 ERZ95660.1 - 0.34 10.5 2.8 0.14 11.7 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) ELFV_dehydrog PF00208.16 ERZ95661.1 - 1.1e-28 100.4 0.0 2e-28 99.6 0.0 1.3 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 ERZ95661.1 - 1.2e-21 76.6 0.0 2.1e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.14 ERZ95661.1 - 0.019 14.1 0.0 0.036 13.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 ERZ95661.1 - 0.024 13.9 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 ERZ95661.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.13 ERZ95661.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosom_S12_S23 PF00164.20 ERZ95662.1 - 2.4e-47 159.3 0.6 2.5e-47 159.2 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 TLD PF07534.11 ERZ95663.1 - 3.1e-07 30.4 0.1 3.4e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 TLD DUF4176 PF13780.1 ERZ95665.1 - 0.091 12.4 0.2 8.1 6.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4176) DUF3130 PF11328.3 ERZ95666.1 - 0.095 12.7 0.1 0.26 11.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3130 GAGA_bind PF06217.7 ERZ95668.1 - 0.032 14.1 13.9 0.077 12.9 9.7 1.6 1 1 0 1 1 1 0 GAGA binding protein-like family DUF2152 PF10222.4 ERZ95668.1 - 0.081 11.1 8.1 0.091 10.9 5.6 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) DUF3869 PF12985.2 ERZ95668.1 - 0.097 13.1 0.5 0.097 13.1 0.3 2.2 2 1 0 3 3 3 0 Domain of unknown function (DUF3869) ATG16 PF08614.6 ERZ95668.1 - 0.36 10.6 34.8 0.49 10.1 14.2 2.8 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.6 ERZ95668.1 - 0.46 9.0 40.3 0.48 9.0 13.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Hormone_1 PF00103.15 ERZ95668.1 - 0.93 8.7 12.4 2.3 7.4 3.5 2.4 1 1 1 2 2 2 0 Somatotropin hormone family ZYG-11_interact PF05884.7 ERZ95668.1 - 1.4 7.9 11.9 0.75 8.8 1.2 2.1 1 1 1 2 2 2 0 Interactor of ZYG-11 AAA_13 PF13166.1 ERZ95668.1 - 4.2 5.7 31.6 4.8 5.5 21.9 1.1 1 0 0 1 1 1 0 AAA domain DUF3552 PF12072.3 ERZ95668.1 - 6.6 5.8 34.7 21 4.2 16.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF745 PF05335.8 ERZ95668.1 - 9.8 5.6 18.1 15 5.0 11.4 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Polyoma_agno PF01736.11 ERZ95669.1 - 0.028 14.0 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Polyomavirus agnoprotein Sel1 PF08238.7 ERZ95673.1 - 2.2e-158 511.2 89.4 2.1e-12 47.2 0.5 17.1 17 0 0 17 17 17 17 Sel1 repeat Flu_M1_C PF08289.6 ERZ95673.1 - 2.5e-11 43.4 0.0 11 6.1 0.0 9.4 4 3 6 11 11 11 1 Influenza Matrix protein (M1) C-terminal domain MIT PF04212.13 ERZ95673.1 - 1.6e-09 37.4 71.5 0.67 9.8 0.0 14.5 12 4 3 15 15 15 8 MIT (microtubule interacting and transport) domain TPR_20 PF14561.1 ERZ95673.1 - 3.3e-07 30.3 18.7 2.5 8.2 0.0 9.5 2 2 9 12 12 12 1 Tetratricopeptide repeat HTH_16 PF12645.2 ERZ95673.1 - 0.0006 19.6 4.1 0.087 12.7 0.0 5.1 5 0 0 5 5 5 1 Helix-turn-helix domain TPR_16 PF13432.1 ERZ95673.1 - 0.0017 19.0 26.8 9.7 6.9 0.2 8.9 4 2 7 11 11 11 1 Tetratricopeptide repeat Tubulin_C PF03953.12 ERZ95673.1 - 0.14 12.2 0.1 17 5.4 0.0 3.7 2 1 2 4 4 4 0 Tubulin C-terminal domain FTCD_N PF07837.7 ERZ95673.1 - 0.17 11.3 2.0 33 3.9 0.0 4.6 3 1 1 4 4 4 0 Formiminotransferase domain, N-terminal subdomain DUF3087 PF11286.3 ERZ95673.1 - 0.25 10.5 31.8 3.6 6.8 0.2 10.3 4 3 7 12 12 12 0 Protein of unknown function (DUF3087) PNPase PF03726.9 ERZ95673.1 - 1.3 9.3 15.5 39 4.6 0.1 7.8 8 3 2 10 10 10 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain CitT PF12431.3 ERZ95673.1 - 5.3 7.2 12.3 63 3.8 0.0 6.7 8 0 0 8 8 8 0 Transcriptional regulator MazG-like PF12643.2 ERZ95675.1 - 0.12 12.2 0.1 0.13 12.1 0.1 1.1 1 0 0 1 1 1 0 MazG-like family WD40 PF00400.27 ERZ95676.1 - 1.3e-25 88.2 1.4 1.9e-07 30.6 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Pox_G7 PF05503.7 ERZ95677.1 - 0.0033 16.1 0.1 0.0039 15.8 0.1 1.2 1 0 0 1 1 1 1 Poxvirus G7-like Pkinase_Tyr PF07714.12 ERZ95679.1 - 6e-07 28.7 0.1 1.6e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95679.1 - 0.0092 15.1 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PIF1 PF05970.9 ERZ95680.1 - 0.00021 20.3 1.8 0.00093 18.2 1.3 2.0 1 1 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.1 ERZ95681.1 - 7.2e-10 38.8 6.2 0.00025 20.8 0.4 2.9 2 1 1 3 3 3 2 Helitron helicase-like domain at N-terminus DUF3627 PF12299.3 ERZ95682.1 - 0.038 14.0 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3627) Rad60-SLD PF11976.3 ERZ95683.1 - 1.1e-07 31.4 0.2 1.8e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ERZ95683.1 - 1.7e-05 24.1 1.6 0.096 12.0 0.7 2.3 2 0 0 2 2 2 2 Ubiquitin family NdhO PF11910.3 ERZ95683.1 - 0.087 12.4 0.1 0.59 9.8 0.0 2.3 3 0 0 3 3 3 0 Cyanobacterial and plant NDH-1 subunit O SH3_2 PF07653.12 ERZ95683.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain PMSI1 PF15322.1 ERZ95684.1 - 0.19 10.8 0.5 0.19 10.7 0.3 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative SmpA_OmlA PF04355.8 ERZ95686.1 - 0.084 12.4 0.1 0.59 9.7 0.0 2.0 2 0 0 2 2 2 0 SmpA / OmlA family FeoC PF09012.5 ERZ95687.1 - 0.048 13.3 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator LAM_C PF12544.3 ERZ95691.1 - 0.016 15.2 4.2 1.5 8.8 0.4 2.4 1 1 1 2 2 2 0 Lysine-2,3-aminomutase GCOM2 PF15328.1 ERZ95692.1 - 0.00012 21.9 13.8 0.00012 21.9 9.5 1.5 1 1 1 2 2 2 1 Putative GRINL1B complex locus protein 2 PocR PF10114.4 ERZ95692.1 - 0.048 12.8 0.5 0.073 12.2 0.3 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR Syntaxin-6_N PF09177.6 ERZ95692.1 - 0.96 9.8 10.8 2.7 8.4 0.5 2.8 2 1 1 3 3 3 0 Syntaxin 6, N-terminal ORC3_N PF07034.6 ERZ95694.1 - 6.9e-20 71.2 0.5 6.9e-20 71.2 0.3 2.1 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus APP_E2 PF12925.2 ERZ95694.1 - 0.00067 19.2 2.2 0.0015 18.1 1.5 1.6 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein ATP_synt_H PF05493.8 ERZ95695.1 - 1.3e-20 73.1 4.0 1.5e-20 73.0 2.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit H Cation_ATPase_C PF00689.16 ERZ95695.1 - 0.04 13.4 0.2 0.048 13.1 0.2 1.0 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF4079 PF13301.1 ERZ95695.1 - 0.054 13.5 0.4 0.079 12.9 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) YibE_F PF07907.6 ERZ95695.1 - 0.054 12.6 4.2 0.06 12.5 2.9 1.0 1 0 0 1 1 1 0 YibE/F-like protein EamA PF00892.15 ERZ95695.1 - 0.071 13.1 2.6 0.077 13.0 1.8 1.1 1 0 0 1 1 1 0 EamA-like transporter family ARL6IP6 PF15062.1 ERZ95695.1 - 0.077 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix DUF1345 PF07077.6 ERZ95695.1 - 0.16 11.4 0.7 0.18 11.2 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) Ribosomal_S8e PF01201.17 ERZ95696.1 - 4.7e-39 133.5 0.0 2.2e-37 128.1 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8e Gp49 PF05973.9 ERZ95696.1 - 0.052 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) PBP1_TM PF14812.1 ERZ95696.1 - 0.057 13.7 1.1 0.057 13.7 0.8 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-CCHC_6 PF15288.1 ERZ95696.1 - 0.091 12.4 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle PCI PF01399.22 ERZ95697.1 - 8.4e-09 35.6 0.1 8.4e-09 35.6 0.1 3.4 3 1 0 3 3 3 1 PCI domain DUF3639 PF12341.3 ERZ95698.1 - 3e-08 33.5 0.1 7.3e-08 32.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3639) Pkinase PF00069.20 ERZ95699.1 - 1.5e-23 83.2 0.0 1.7e-23 83.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95699.1 - 1.8e-20 73.1 0.0 1.9e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ95699.1 - 0.0047 16.6 0.1 0.0067 16.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ95699.1 - 0.024 13.5 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ERZ95699.1 - 0.1 11.9 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 RIO1 family CPSF_A PF03178.10 ERZ95701.1 - 0.0094 15.0 0.1 0.031 13.3 0.0 1.8 2 1 0 2 2 2 1 CPSF A subunit region HnRNP_M PF11532.3 ERZ95702.1 - 0.00098 19.1 3.1 0.0012 18.9 1.2 1.9 2 0 0 2 2 2 1 Heterogeneous nuclear ribonucleoprotein M Ded_cyto PF06920.8 ERZ95702.1 - 0.01 15.1 0.2 0.015 14.6 0.1 1.2 1 0 0 1 1 1 0 Dedicator of cytokinesis GPI-anchored PF10342.4 ERZ95704.1 - 0.00023 21.5 0.0 0.00028 21.3 0.0 1.1 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.1 ERZ95704.1 - 0.06 12.8 0.0 0.14 11.5 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4448) Pkinase PF00069.20 ERZ95705.1 - 2.1e-71 240.1 0.1 7.3e-71 238.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95705.1 - 1.2e-53 181.8 0.0 2.2e-53 180.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 ERZ95705.1 - 1.5e-21 76.2 1.1 3.4e-21 75.1 0.7 1.6 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 ERZ95705.1 - 6.4e-13 48.3 0.1 1.8e-12 46.8 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ERZ95705.1 - 5.8e-12 45.6 0.1 1.4e-11 44.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 ERZ95705.1 - 2.1e-09 37.7 0.1 4.2e-09 36.7 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.1 ERZ95705.1 - 6.9e-08 31.8 0.0 4.9e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ95705.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ste50p-SAM PF09235.5 ERZ95705.1 - 0.17 11.9 2.1 1.1 9.3 0.3 2.6 2 0 0 2 2 2 0 Ste50p, sterile alpha motif MoCF_biosynth PF00994.19 ERZ95706.1 - 4.7e-58 194.6 0.9 1e-28 99.5 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.12 ERZ95706.1 - 1.4e-35 122.0 2.7 2.4e-35 121.3 1.9 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.10 ERZ95706.1 - 6.6e-13 48.4 0.0 1.6e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) adh_short PF00106.20 ERZ95707.1 - 1.8e-23 83.2 0.0 2.6e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ95707.1 - 3.5e-10 39.8 0.0 5.2e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ERZ95707.1 - 1.6e-06 28.1 0.0 2.2e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.14 ERZ95707.1 - 0.00011 21.2 0.0 0.00021 20.3 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.1 ERZ95707.1 - 0.00073 19.5 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 NADH(P)-binding 3HCDH_N PF02737.13 ERZ95707.1 - 0.0014 18.3 0.1 0.0022 17.6 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 ERZ95707.1 - 0.0041 16.1 0.1 0.0077 15.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 ERZ95707.1 - 0.014 14.8 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_Gly3P_dh_N PF01210.18 ERZ95707.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 ERZ95707.1 - 0.048 13.0 0.1 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 5_3_exonuc_N PF02739.11 ERZ95707.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Shikimate_DH PF01488.15 ERZ95707.1 - 0.095 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Med6 PF04934.9 ERZ95708.1 - 1.5e-43 147.7 0.8 1.5e-43 147.7 0.5 1.6 2 0 0 2 2 2 1 MED6 mediator sub complex component Metallophos PF00149.23 ERZ95709.1 - 1.7e-37 128.8 0.6 2.2e-37 128.3 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ERZ95709.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Aldo_ket_red PF00248.16 ERZ95710.1 - 3.9e-05 22.6 0.0 3.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase_Tyr PF07714.12 ERZ95712.1 - 2.4e-52 177.5 0.0 4.1e-52 176.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95712.1 - 1.4e-47 162.0 0.8 1.6e-46 158.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ERZ95712.1 - 0.0064 16.2 0.0 0.037 13.7 0.1 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family ELF PF03317.8 ERZ95713.1 - 0.047 12.9 1.1 0.05 12.8 0.8 1.1 1 0 0 1 1 1 0 ELF protein ATG22 PF11700.3 ERZ95715.1 - 5.5e-144 480.2 26.8 6.2e-144 480.0 18.6 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 ERZ95715.1 - 6.4e-13 48.1 26.9 1.1e-08 34.2 6.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily SKG6 PF08693.5 ERZ95715.1 - 0.62 9.4 4.3 0.61 9.4 0.3 2.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Symplekin_C PF12295.3 ERZ95717.1 - 5.5e-39 133.9 4.3 5.5e-39 133.9 3.0 1.8 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal DUF3074 PF11274.3 ERZ95717.1 - 0.13 11.8 0.2 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3074) IZUMO PF15005.1 ERZ95717.1 - 0.45 10.5 3.6 7.1 6.6 0.1 2.9 3 0 0 3 3 3 0 Izumo sperm-egg fusion DUF3421 PF11901.3 ERZ95718.1 - 1.4e-31 108.7 16.7 1.7e-15 56.7 0.2 3.8 1 1 3 4 4 4 4 Protein of unknown function (DUF3421) Asp_Arg_Hydrox PF05118.10 ERZ95718.1 - 0.0017 18.1 0.5 1.6 8.5 0.0 2.2 2 0 0 2 2 2 2 Aspartyl/Asparaginyl beta-hydroxylase F-box-like PF12937.2 ERZ95719.1 - 6.5e-09 35.3 0.5 1.4e-08 34.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ERZ95719.1 - 0.065 12.9 11.0 2 8.2 0.4 4.6 4 1 0 4 4 4 0 Leucine rich repeat Sel1 PF08238.7 ERZ95720.1 - 5.2e-151 487.8 56.3 8.4e-10 38.9 0.1 20.2 20 0 0 20 20 20 18 Sel1 repeat TPR_16 PF13432.1 ERZ95720.1 - 4.7e-05 23.9 0.4 2.9 8.6 0.0 6.3 7 1 1 8 8 8 1 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ERZ95720.1 - 0.0041 16.8 5.2 0.2 11.4 0.0 4.8 4 1 0 4 4 4 1 Aurora-A binding TPR_6 PF13174.1 ERZ95720.1 - 0.0049 17.2 24.4 13 6.5 0.0 11.4 16 0 0 16 16 16 1 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ95720.1 - 0.0061 17.0 0.3 64 4.6 0.0 5.2 5 2 0 5 5 5 0 Tetratricopeptide repeat Bac_luciferase PF00296.15 ERZ95720.1 - 0.055 12.5 0.1 2.5 7.1 0.0 2.5 3 0 0 3 3 3 0 Luciferase-like monooxygenase Kelch_3 PF13415.1 ERZ95721.1 - 1e-20 73.2 12.6 1.5e-05 25.0 0.1 6.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ERZ95721.1 - 3.2e-20 71.6 7.4 3e-05 23.6 0.3 5.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ERZ95721.1 - 2.1e-09 37.1 2.9 0.00025 20.9 0.0 5.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 ERZ95721.1 - 1.3e-06 28.3 4.1 0.37 11.0 0.1 4.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ERZ95721.1 - 0.00013 21.4 3.5 0.33 10.5 0.0 4.5 4 0 0 4 4 4 1 Kelch motif Cytochrom_B561 PF03188.11 ERZ95721.1 - 0.0028 17.5 2.1 0.0028 17.5 1.5 2.2 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF998 PF06197.8 ERZ95721.1 - 0.0056 16.0 0.2 0.0056 16.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF998) Kelch_2 PF07646.10 ERZ95721.1 - 0.065 13.0 5.1 51 3.8 0.0 5.1 5 0 0 5 5 5 0 Kelch motif MerC PF03203.9 ERZ95721.1 - 2.5 8.5 9.4 4.4 7.7 0.9 2.4 2 0 0 2 2 2 0 MerC mercury resistance protein Pkinase_Tyr PF07714.12 ERZ95722.1 - 3.5e-58 196.7 0.1 4.3e-58 196.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95722.1 - 1.3e-51 175.2 0.9 1.7e-51 174.8 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ95722.1 - 0.0039 16.5 0.2 0.0091 15.3 0.1 1.5 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ95722.1 - 0.0065 16.2 0.0 0.014 15.1 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ95722.1 - 0.03 13.3 0.1 0.045 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ95722.1 - 0.053 12.4 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PfkB PF00294.19 ERZ95723.1 - 5.5e-37 127.5 0.0 7e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Rep_2 PF01719.12 ERZ95723.1 - 0.089 12.2 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Plasmid replication protein WD40 PF00400.27 ERZ95724.1 - 4.8e-22 76.9 11.1 1.4e-08 34.2 0.1 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat Rax2 PF12768.2 ERZ95724.1 - 0.00013 21.2 0.7 0.00081 18.6 0.0 2.2 2 0 0 2 2 2 1 Cortical protein marker for cell polarity DPPIV_N PF00930.16 ERZ95724.1 - 0.0017 17.0 1.1 0.028 12.9 0.1 2.6 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region eIF2A PF08662.6 ERZ95724.1 - 0.0052 16.5 1.8 0.32 10.6 0.1 3.0 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A CBS PF00571.23 ERZ95725.1 - 6.4e-37 125.0 8.7 2.6e-10 39.9 0.0 5.2 5 0 0 5 5 5 4 CBS domain PB1 PF00564.19 ERZ95725.1 - 1.2e-08 34.4 0.1 2.8e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 PB1 domain DUF4603 PF15376.1 ERZ95725.1 - 0.51 7.4 2.8 0.86 6.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Methyltransf_31 PF13847.1 ERZ95726.1 - 1.6e-11 44.0 0.0 7.5e-11 41.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ95726.1 - 3e-11 43.5 0.0 1.1e-10 41.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ95726.1 - 1e-10 41.9 0.0 2e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ95726.1 - 1.5e-10 41.0 0.0 2.3e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ95726.1 - 5.3e-06 26.9 0.0 1.3e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ95726.1 - 3.2e-05 23.1 0.0 6.6e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ERZ95726.1 - 0.00021 21.7 0.0 0.0009 19.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ERZ95726.1 - 0.00055 19.9 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase MetW PF07021.7 ERZ95726.1 - 0.0082 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.9 ERZ95726.1 - 0.015 14.4 0.0 0.038 13.1 0.0 1.7 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_26 PF13659.1 ERZ95726.1 - 0.031 14.2 0.0 0.073 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ95726.1 - 0.034 13.1 0.0 0.2 10.7 0.0 2.2 2 1 1 3 3 3 0 Putative methyltransferase APP_N PF02177.11 ERZ95726.1 - 0.077 12.9 1.4 0.1 12.5 0.2 1.8 1 1 1 2 2 2 0 Amyloid A4 N-terminal heparin-binding Phage_int_SAM_5 PF13102.1 ERZ95726.1 - 0.32 11.0 0.0 0.32 11.0 0.0 2.6 3 0 0 3 3 3 0 Phage integrase SAM-like domain Methyltransf_23 PF13489.1 ERZ95727.1 - 2.8e-19 69.4 0.0 4.3e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ95727.1 - 4.2e-17 62.1 0.0 1.9e-16 60.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ95727.1 - 2e-15 57.0 0.0 4.5e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ95727.1 - 1.4e-12 47.8 0.0 4e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ95727.1 - 1e-11 45.3 0.0 2.4e-10 41.0 0.0 2.6 2 1 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ95727.1 - 1.3e-10 40.7 0.0 2.8e-10 39.7 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ERZ95727.1 - 4.1e-10 40.0 0.0 2e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ95727.1 - 3.4e-09 36.0 0.0 9.3e-08 31.3 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase CheR PF01739.13 ERZ95727.1 - 3.8e-05 23.0 0.0 0.0024 17.1 0.0 2.2 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain MTS PF05175.9 ERZ95727.1 - 4.4e-05 22.9 0.0 8.5e-05 21.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ERZ95727.1 - 0.00017 21.5 0.0 0.00037 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ERZ95727.1 - 0.00026 20.6 0.0 0.00054 19.6 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase FtsJ PF01728.14 ERZ95727.1 - 0.00054 19.9 0.0 0.00086 19.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ERZ95727.1 - 0.00081 18.6 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase RrnaAD PF00398.15 ERZ95727.1 - 0.00094 18.2 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CMAS PF02353.15 ERZ95727.1 - 0.0063 15.6 0.1 0.016 14.2 0.0 1.9 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.11 ERZ95727.1 - 0.022 13.1 0.0 0.35 9.1 0.0 2.0 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 ERZ95727.1 - 0.023 14.0 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.14 ERZ95727.1 - 0.038 13.5 0.0 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.4 ERZ95727.1 - 0.054 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_9 PF08003.6 ERZ95727.1 - 0.075 11.7 0.0 0.16 10.6 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) DUF938 PF06080.7 ERZ95727.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) HA2 PF04408.18 ERZ95728.1 - 3e-27 94.6 0.0 3e-27 94.6 0.0 3.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ERZ95728.1 - 7.1e-25 87.0 0.0 6e-24 84.0 0.0 2.5 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ERZ95728.1 - 2.1e-13 49.9 0.0 6.2e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ERZ95728.1 - 3.8e-07 29.7 0.3 1.7e-06 27.5 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ERZ95728.1 - 1.4e-05 25.2 0.0 6.5e-05 23.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ERZ95728.1 - 0.0026 16.7 0.0 0.0052 15.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.1 ERZ95728.1 - 0.0093 15.5 0.0 0.024 14.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ERZ95728.1 - 0.013 15.2 3.3 0.018 14.7 0.0 2.7 3 0 0 3 3 3 0 Archaeal ATPase Flavi_DEAD PF07652.9 ERZ95728.1 - 0.034 13.8 0.1 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Sigma54_activ_2 PF14532.1 ERZ95728.1 - 0.075 13.0 0.0 0.27 11.2 0.0 2.0 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.22 ERZ95728.1 - 0.08 13.2 1.4 0.25 11.6 0.0 2.6 2 1 0 2 2 2 0 ABC transporter AAA_19 PF13245.1 ERZ95728.1 - 0.15 11.7 0.0 0.42 10.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_23 PF13476.1 ERZ95728.1 - 0.51 10.6 0.0 0.51 10.6 0.0 4.3 4 2 0 4 4 2 0 AAA domain Swi3 PF07962.7 ERZ95729.1 - 1.3e-17 63.1 0.3 1.3e-17 63.1 0.2 1.7 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 Ank PF00023.25 ERZ95730.1 - 4.2e-08 32.6 0.2 9.4e-08 31.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.2 ERZ95730.1 - 2.2e-06 27.8 0.0 5.4e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ERZ95730.1 - 4.1e-06 26.8 0.0 9.3e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ERZ95730.1 - 0.001 19.1 0.1 0.003 17.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.1 ERZ95730.1 - 0.012 16.1 0.0 0.032 14.7 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF2215 PF10225.4 ERZ95730.1 - 4.5 6.6 8.6 1.8 7.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) DDE_1 PF03184.14 ERZ95732.1 - 4.3e-12 45.6 0.0 4.3e-12 45.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RF-1 PF00472.15 ERZ95734.1 - 2.6e-18 65.8 2.1 5.4e-18 64.8 1.4 1.5 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.4 ERZ95734.1 - 0.015 15.4 1.2 0.015 15.4 0.8 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit protein Polysacc_deac_1 PF01522.16 ERZ95735.1 - 2.5e-34 117.5 0.0 5e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2194 PF09960.4 ERZ95735.1 - 0.025 12.6 0.0 0.035 12.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2194) Syntaphilin PF15290.1 ERZ95736.1 - 0.0063 16.0 0.1 0.011 15.2 0.0 1.4 1 1 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp FlaC_arch PF05377.6 ERZ95736.1 - 0.02 14.7 0.4 0.039 13.8 0.3 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF2353 PF09789.4 ERZ95736.1 - 0.03 13.5 2.2 0.028 13.6 1.5 1.0 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Vac_Fusion PF02346.11 ERZ95736.1 - 0.082 12.3 0.9 0.2 11.1 0.6 1.7 1 0 0 1 1 1 0 Chordopoxvirus fusion protein ABC_tran_2 PF12848.2 ERZ95736.1 - 0.088 12.6 0.1 0.088 12.6 0.1 1.6 2 0 0 2 2 2 0 ABC transporter Pox_A_type_inc PF04508.7 ERZ95736.1 - 0.13 12.1 1.9 0.59 10.0 1.3 2.2 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat CENP-Q PF13094.1 ERZ95736.1 - 0.16 11.9 3.2 0.22 11.5 2.1 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Noelin-1 PF12308.3 ERZ95736.1 - 0.17 11.7 1.0 0.23 11.2 0.7 1.3 1 0 0 1 1 1 0 Neurogenesis glycoprotein DUF641 PF04859.7 ERZ95736.1 - 0.18 11.5 2.5 0.23 11.1 1.7 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Prefoldin_2 PF01920.15 ERZ95736.1 - 0.35 10.6 5.3 0.67 9.7 3.7 1.6 1 1 0 1 1 1 0 Prefoldin subunit TMF_DNA_bd PF12329.3 ERZ95736.1 - 0.39 10.5 4.5 1.1 9.0 3.1 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Phage_integrase PF00589.17 ERZ95737.1 - 3.2e-06 26.9 0.0 6.4e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family MACPF PF01823.14 ERZ95738.1 - 0.002 17.8 1.2 0.002 17.8 0.8 2.2 1 1 1 2 2 2 1 MAC/Perforin domain Pkinase_Tyr PF07714.12 ERZ95741.1 - 0.0053 15.8 0.0 0.0078 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95741.1 - 0.031 13.4 0.2 0.058 12.5 0.1 1.5 1 1 0 1 1 1 0 Protein kinase domain Wbp11 PF09429.5 ERZ95741.1 - 0.47 10.4 3.2 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 WW domain binding protein 11 Pkinase_Tyr PF07714.12 ERZ95742.1 - 0.044 12.8 0.0 0.062 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.20 ERZ95742.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95743.1 - 3.1e-13 49.3 0.5 2.5e-12 46.4 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95743.1 - 1.7e-12 47.0 0.1 2.2e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95744.1 - 2.7e-21 75.8 0.0 3.6e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95744.1 - 4.6e-16 58.7 0.6 1e-15 57.5 0.2 1.8 2 1 0 2 2 2 1 Protein kinase domain APH PF01636.18 ERZ95744.1 - 0.063 12.9 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ95745.1 - 5.7e-07 28.8 0.2 0.021 13.8 0.0 4.1 3 1 0 4 4 4 3 Protein tyrosine kinase BCS1_N PF08740.6 ERZ95745.1 - 7.4e-06 25.7 0.1 1 8.9 0.0 3.7 3 0 0 3 3 3 3 BCS1 N terminal Prp18 PF02840.10 ERZ95745.1 - 0.011 15.5 0.9 14 5.5 0.0 4.0 4 0 0 4 4 4 0 Prp18 domain SF3a60_bindingd PF12108.3 ERZ95745.1 - 0.84 9.2 12.6 31 4.2 0.1 5.4 5 0 0 5 5 5 0 Splicing factor SF3a60 binding domain DUF3537 PF12056.3 ERZ95746.1 - 0.069 11.8 0.1 0.12 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Zn_clus PF00172.13 ERZ95747.1 - 2.8e-06 27.1 18.0 5e-06 26.3 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCHC PF00098.18 ERZ95748.1 - 2.3e-07 30.3 2.5 3.3e-07 29.9 1.8 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ERZ95748.1 - 0.013 15.0 0.8 0.045 13.2 0.1 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 ERZ95748.1 - 0.018 14.7 0.8 0.018 14.7 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.1 ERZ95748.1 - 0.058 12.8 1.7 0.1 12.0 1.2 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger PBP1_TM PF14812.1 ERZ95748.1 - 9.7 6.5 12.6 67 3.8 8.7 2.1 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Prefoldin PF02996.12 ERZ95749.1 - 8.7e-27 93.1 2.4 1.2e-26 92.6 1.7 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 ERZ95749.1 - 5e-06 26.1 1.2 1.3e-05 24.8 0.8 1.8 1 1 0 1 1 1 1 Prefoldin subunit TMF_TATA_bd PF12325.3 ERZ95749.1 - 0.0026 17.4 3.0 0.017 14.8 0.7 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding COG2 PF06148.6 ERZ95749.1 - 0.0072 16.1 1.3 1.8 8.4 0.1 2.2 2 0 0 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin_2 PF01920.15 ERZ95749.1 - 0.026 14.2 4.9 2.2 8.0 0.8 2.3 2 0 0 2 2 2 0 Prefoldin subunit DUF4463 PF14703.1 ERZ95749.1 - 0.034 14.6 1.3 0.14 12.7 0.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) Spc7 PF08317.6 ERZ95749.1 - 0.039 12.6 3.3 0.06 12.0 0.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein COG5 PF10392.4 ERZ95749.1 - 0.043 13.7 1.4 0.96 9.4 0.1 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DivIVA PF05103.8 ERZ95749.1 - 0.044 13.8 2.8 2.7 8.0 0.4 2.2 2 0 0 2 2 2 0 DivIVA protein Snapin_Pallidin PF14712.1 ERZ95749.1 - 0.064 13.5 8.0 1.2 9.5 0.4 2.9 2 1 1 3 3 3 0 Snapin/Pallidin CENP-Q PF13094.1 ERZ95749.1 - 0.12 12.4 2.0 0.14 12.1 0.4 1.7 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit THF_DHG_CYH_C PF02882.14 ERZ95749.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ADIP PF11559.3 ERZ95749.1 - 0.24 11.3 4.0 2.5 8.0 1.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Tektin PF03148.9 ERZ95749.1 - 0.26 9.7 3.8 0.26 9.7 0.9 1.8 2 0 0 2 2 2 0 Tektin family Syntaxin PF00804.20 ERZ95749.1 - 0.32 11.1 5.2 1.9 8.6 3.6 2.1 1 1 0 1 1 1 0 Syntaxin DUF972 PF06156.8 ERZ95749.1 - 0.45 10.8 2.5 0.91 9.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) M PF02370.11 ERZ95749.1 - 2 9.0 6.2 1.4 9.5 1.7 2.3 2 0 0 2 2 2 0 M protein repeat EOS1 PF12326.3 ERZ95750.1 - 2.1e-19 69.6 10.2 4.2e-19 68.6 7.1 1.5 1 0 0 1 1 1 1 N-glycosylation protein Galactosyl_T PF01762.16 ERZ95750.1 - 5.8e-14 52.1 0.2 9.1e-14 51.5 0.1 1.3 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_L14 PF00238.14 ERZ95751.1 - 1e-23 83.3 0.0 8.8e-23 80.3 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e DUF846 PF05832.7 ERZ95752.1 - 7.1e-53 178.1 11.2 8e-53 177.9 7.8 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) CitMHS PF03600.11 ERZ95752.1 - 0.013 14.1 1.9 0.015 13.8 1.3 1.1 1 0 0 1 1 1 0 Citrate transporter DUF4149 PF13664.1 ERZ95752.1 - 0.03 14.3 3.9 0.094 12.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) HXXEE PF13787.1 ERZ95752.1 - 0.062 13.6 0.7 0.062 13.6 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif PRA1 PF03208.14 ERZ95752.1 - 0.42 9.9 6.5 0.43 9.9 3.5 1.7 1 1 1 2 2 2 0 PRA1 family protein Wzy_C PF04932.10 ERZ95752.1 - 0.47 10.2 7.1 0.16 11.7 1.1 2.1 2 0 0 2 2 2 0 O-Antigen ligase TcpE PF12648.2 ERZ95752.1 - 1.1 9.3 8.2 0.35 11.0 0.3 2.2 2 0 0 2 2 2 0 TcpE family DUF3784 PF12650.2 ERZ95752.1 - 7.9 6.4 13.1 1 9.3 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF846 PF05832.7 ERZ95753.1 - 7e-52 174.9 10.2 8.3e-52 174.6 7.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) YfhO PF09586.5 ERZ95753.1 - 0.034 12.1 2.6 0.054 11.5 1.8 1.2 1 1 0 1 1 1 0 Bacterial membrane protein YfhO Flavi_NS2A PF01005.14 ERZ95753.1 - 0.46 9.7 3.6 9.1 5.5 0.5 2.1 2 0 0 2 2 2 0 Flavivirus non-structural protein NS2A PRA1 PF03208.14 ERZ95753.1 - 0.94 8.8 6.5 0.79 9.0 2.6 1.9 1 1 1 2 2 2 0 PRA1 family protein TcpE PF12648.2 ERZ95753.1 - 1.3 9.2 7.5 0.3 11.2 0.4 2.2 2 0 0 2 2 2 0 TcpE family DUF2418 PF10332.4 ERZ95753.1 - 1.5 9.1 6.3 16 5.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) DUF3792 PF12670.2 ERZ95753.1 - 2.3 8.1 7.5 0.25 11.2 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) 14-3-3 PF00244.15 ERZ95754.1 - 8.1e-105 349.1 2.3 9.4e-105 348.9 1.6 1.0 1 0 0 1 1 1 1 14-3-3 protein Sel1 PF08238.7 ERZ95756.1 - 4.7e-65 214.6 55.0 4.4e-08 33.5 1.9 12.1 12 0 0 12 12 12 11 Sel1 repeat TPR_12 PF13424.1 ERZ95756.1 - 0.0056 16.5 6.9 0.24 11.3 0.0 4.5 2 2 2 4 4 4 1 Tetratricopeptide repeat Prenyltrans_1 PF13243.1 ERZ95756.1 - 1.4 9.0 7.1 0.26 11.3 0.1 3.2 3 1 2 5 5 5 0 Prenyltransferase-like TPR_6 PF13174.1 ERZ95756.1 - 9.9 6.8 30.4 48 4.7 0.0 9.1 11 0 0 11 11 11 0 Tetratricopeptide repeat RRM_1 PF00076.17 ERZ95759.1 - 1.4e-05 24.6 0.0 0.0031 17.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ95759.1 - 0.0061 16.5 0.0 0.024 14.5 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MbeD_MobD PF04899.7 ERZ95759.1 - 0.099 12.5 0.0 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 MbeD/MobD like IBV_3C PF03620.8 ERZ95761.1 - 0.0043 16.9 0.1 0.0095 15.8 0.0 1.5 1 0 0 1 1 1 1 IBV 3C protein PHA-1 PF06542.6 ERZ95762.1 - 0.039 12.6 0.1 0.049 12.3 0.0 1.0 1 0 0 1 1 1 0 Regulator protein PHA-1 DUF4337 PF14235.1 ERZ95762.1 - 0.087 12.6 0.3 0.094 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF885 PF05960.6 ERZ95762.1 - 0.088 11.9 0.1 0.09 11.9 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Pyr_redox_2 PF07992.9 ERZ95764.1 - 8.5e-22 78.0 0.0 2.5e-21 76.5 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ERZ95764.1 - 5.4e-10 39.5 0.1 2.7e-09 37.3 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ERZ95764.1 - 0.0004 20.4 0.0 1.4 8.9 0.0 2.8 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pkinase_Tyr PF07714.12 ERZ95765.1 - 1.3e-45 155.4 0.2 1.3e-45 155.4 0.1 1.8 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95765.1 - 4.1e-44 150.6 1.7 4.1e-44 150.6 1.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ERZ95765.1 - 1.5e-23 82.6 9.4 1.2e-06 28.9 0.6 5.5 5 0 0 5 5 5 4 Sel1 repeat RIO1 PF01163.17 ERZ95765.1 - 2.4e-05 23.7 0.2 5.7e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ95765.1 - 0.00064 18.7 0.0 0.003 16.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ95765.1 - 0.0022 17.7 0.0 0.0033 17.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ95765.1 - 0.007 15.4 0.1 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ERZ95767.1 - 1.4e-43 148.9 0.0 1.8e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95767.1 - 2.5e-43 148.1 0.0 3.9e-43 147.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HisG PF01634.13 ERZ95769.1 - 9.7e-49 165.0 0.9 1.3e-48 164.6 0.6 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 ERZ95769.1 - 1.6e-28 98.4 0.4 5.5e-28 96.7 0.0 2.0 2 0 0 2 2 2 1 HisG, C-terminal domain APH PF01636.18 ERZ95770.1 - 4e-32 111.8 0.0 8.4e-32 110.8 0.0 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ERZ95770.1 - 1e-06 28.1 0.0 7.2e-06 25.3 0.0 2.0 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 ERZ95770.1 - 6.9e-06 25.7 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 ERZ95770.1 - 0.0066 15.1 0.0 0.055 12.0 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) An_peroxidase PF03098.10 ERZ95771.1 - 6.8e-52 176.5 0.0 7.3e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase DivIC PF04977.10 ERZ95772.1 - 0.0083 15.5 5.1 0.0083 15.5 3.5 4.1 1 1 0 3 3 3 1 Septum formation initiator KLRAQ PF10205.4 ERZ95772.1 - 0.011 15.7 10.1 0.011 15.7 7.0 4.8 1 1 2 4 4 4 0 Predicted coiled-coil domain-containing protein zf-C2H2_4 PF13894.1 ERZ95772.1 - 0.05 13.9 2.4 0.18 12.2 1.7 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ERZ95772.1 - 0.064 13.6 7.0 0.03 14.6 2.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type UPF0183 PF03676.9 ERZ95773.1 - 5e-08 31.9 0.0 5.3e-08 31.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) ThiF PF00899.16 ERZ95774.1 - 4.5e-39 133.3 0.0 8.7e-39 132.4 0.0 1.5 1 0 0 1 1 1 1 ThiF family FAD_binding_3 PF01494.14 ERZ95774.1 - 0.046 12.7 0.1 0.079 11.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.19 ERZ95774.1 - 0.056 12.3 0.1 0.11 11.3 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase TrkA_N PF02254.13 ERZ95774.1 - 0.077 13.0 0.6 0.3 11.0 0.1 2.3 3 0 0 3 3 3 0 TrkA-N domain THOC7 PF05615.8 ERZ95775.1 - 0.002 18.4 0.6 0.0038 17.5 0.4 1.4 1 0 0 1 1 1 1 Tho complex subunit 7 DUF2562 PF10814.3 ERZ95775.1 - 0.005 16.7 0.5 0.009 15.9 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2562) FlaC_arch PF05377.6 ERZ95775.1 - 0.0071 16.2 4.4 0.34 10.8 0.7 2.5 1 1 1 2 2 2 2 Flagella accessory protein C (FlaC) FlhC PF05280.6 ERZ95775.1 - 0.019 14.4 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Corona_S2 PF01601.11 ERZ95775.1 - 0.036 12.1 0.0 0.048 11.7 0.0 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF342 PF03961.8 ERZ95775.1 - 0.066 11.6 1.1 0.084 11.2 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Atg14 PF10186.4 ERZ95775.1 - 0.086 11.7 7.7 0.17 10.8 5.1 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Fib_alpha PF08702.5 ERZ95775.1 - 0.094 12.8 3.3 0.21 11.6 2.3 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TBPIP PF07106.8 ERZ95775.1 - 0.13 11.7 5.7 0.057 12.9 2.4 1.5 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HlyD PF00529.15 ERZ95775.1 - 0.18 11.0 1.6 0.26 10.5 1.1 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF641 PF04859.7 ERZ95775.1 - 0.2 11.3 3.1 0.39 10.4 1.9 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Exonuc_VII_L PF02601.10 ERZ95775.1 - 0.29 10.3 6.7 0.5 9.4 4.7 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Med4 PF10018.4 ERZ95775.1 - 0.38 10.1 7.2 1.5 8.2 2.3 2.3 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 TMF_DNA_bd PF12329.3 ERZ95775.1 - 0.74 9.6 7.1 2.7 7.8 1.8 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Syntaxin_2 PF14523.1 ERZ95775.1 - 0.9 9.6 7.9 0.2 11.7 3.0 1.7 2 0 0 2 2 2 0 Syntaxin-like protein DivIC PF04977.10 ERZ95775.1 - 1.3 8.5 5.5 6.3 6.3 2.3 2.7 2 1 1 3 3 3 0 Septum formation initiator Prefoldin PF02996.12 ERZ95775.1 - 1.4 8.5 4.9 1.9 8.1 0.7 2.2 1 1 1 2 2 2 0 Prefoldin subunit IncA PF04156.9 ERZ95775.1 - 7.2 6.1 8.8 10 5.6 5.1 1.9 2 1 0 2 2 2 0 IncA protein ATG16 PF08614.6 ERZ95775.1 - 8.6 6.1 13.4 3 7.6 7.0 2.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Pyr_redox_2 PF07992.9 ERZ95776.1 - 4.9e-45 153.8 0.3 1.2e-44 152.6 0.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ERZ95776.1 - 1.6e-42 144.0 0.3 2.8e-41 139.9 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ERZ95776.1 - 2.7e-19 69.3 9.3 9.3e-17 61.2 0.3 3.8 4 1 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ERZ95776.1 - 2.6e-10 39.9 5.2 3.9e-10 39.3 0.2 2.6 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.17 ERZ95776.1 - 1.6e-09 37.0 9.8 3e-09 36.2 4.3 2.2 1 1 1 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 ERZ95776.1 - 3.4e-09 37.0 1.4 4e-05 23.7 0.2 2.6 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ERZ95776.1 - 2.7e-08 33.1 7.6 1e-06 27.8 1.3 3.4 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ERZ95776.1 - 3.5e-08 33.3 2.9 0.00015 21.7 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.1 ERZ95776.1 - 1.4e-06 27.4 0.0 0.002 17.1 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.9 ERZ95776.1 - 1.6e-06 26.8 10.2 0.00027 19.5 0.6 4.1 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.12 ERZ95776.1 - 2e-05 23.8 8.5 0.0001 21.5 0.9 2.5 1 1 1 2 2 2 2 Thi4 family FAD_binding_3 PF01494.14 ERZ95776.1 - 0.00011 21.3 9.1 0.063 12.3 0.4 3.3 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.19 ERZ95776.1 - 0.0002 20.3 18.7 0.04 12.8 1.4 4.0 2 2 1 4 4 4 3 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.16 ERZ95776.1 - 0.0027 17.3 0.5 0.15 11.5 0.0 2.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Mqo PF06039.10 ERZ95776.1 - 0.019 13.1 2.1 0.16 10.1 0.1 2.1 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) NAD_binding_7 PF13241.1 ERZ95776.1 - 0.22 11.7 2.3 5.1 7.4 0.5 3.2 2 1 0 2 2 2 0 Putative NAD(P)-binding Lycopene_cycl PF05834.7 ERZ95776.1 - 1.7 7.4 5.6 1.6 7.5 0.3 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein RRM_1 PF00076.17 ERZ95777.1 - 9.3e-55 182.1 2.6 3.5e-21 74.5 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ95777.1 - 1.7e-39 133.6 0.2 3.6e-16 58.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ95777.1 - 2.9e-35 119.9 0.2 1.5e-11 43.9 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ERZ95777.1 - 0.019 14.7 0.1 0.9 9.3 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Calcipressin PF04847.7 ERZ95777.1 - 0.04 13.5 0.0 0.28 10.7 0.0 2.3 2 1 1 3 3 3 0 Calcipressin ArsA_ATPase PF02374.10 ERZ95777.1 - 0.054 12.5 0.1 0.083 11.9 0.1 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase OB_RNB PF08206.6 ERZ95777.1 - 0.066 12.7 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Ribosomal_L29e PF01779.12 ERZ95778.1 - 6e-27 93.2 9.1 9.8e-27 92.5 6.3 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family AT_hook PF02178.14 ERZ95779.1 - 0.34 10.7 9.4 0.15 11.8 1.1 3.0 2 0 0 2 2 2 0 AT hook motif DUF4477 PF14780.1 ERZ95780.1 - 4.8e-10 39.1 0.7 5.8e-10 38.8 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) Phlebovirus_G1 PF07243.6 ERZ95780.1 - 0.02 13.0 0.2 0.022 12.9 0.1 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 RasGEF PF00617.14 ERZ95780.1 - 0.082 12.6 0.1 3.3 7.3 0.0 2.1 1 1 0 2 2 2 0 RasGEF domain Sulfate_transp PF00916.15 ERZ95782.1 - 3.1e-14 52.6 1.4 5.5e-14 51.8 0.9 1.4 1 0 0 1 1 1 1 Sulfate transporter family Sel1 PF08238.7 ERZ95783.1 - 2.2e-103 336.4 36.4 1.2e-11 44.7 0.6 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_16 PF13432.1 ERZ95783.1 - 6e-07 29.9 0.0 0.82 10.4 0.0 5.5 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ95783.1 - 5.3e-06 26.5 2.0 47 4.7 0.0 7.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ95783.1 - 0.0001 22.1 16.1 0.53 10.2 0.3 7.8 3 2 6 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ95783.1 - 0.0071 15.9 44.8 0.39 10.4 3.1 8.1 1 1 5 7 7 7 3 TPR repeat HATPase_c PF02518.21 ERZ95783.1 - 0.028 14.1 0.0 9.7 5.9 0.0 4.4 1 1 1 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MIT PF04212.13 ERZ95783.1 - 0.064 13.1 21.5 1.5 8.7 0.1 7.3 6 3 1 7 7 7 0 MIT (microtubule interacting and transport) domain FliE PF02049.13 ERZ95783.1 - 0.18 11.8 1.2 1.6 8.7 1.0 2.2 2 0 0 2 2 2 0 Flagellar hook-basal body complex protein FliE PAN_3 PF08277.7 ERZ95783.1 - 0.42 10.2 15.7 3.5 7.3 0.1 4.5 3 2 2 5 5 5 0 PAN-like domain SPRY PF00622.23 ERZ95784.1 - 1.4e-08 34.8 0.2 1.6e-08 34.6 0.1 1.0 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.2 ERZ95785.1 - 0.0017 18.0 0.4 0.0046 16.6 0.3 1.8 1 0 0 1 1 1 1 F-box-like EOS1 PF12326.3 ERZ95785.1 - 2.2 7.9 6.8 2.8 7.5 0.8 2.6 2 0 0 2 2 2 0 N-glycosylation protein RNB PF00773.14 ERZ95787.1 - 5.7e-99 331.4 0.1 1e-98 330.6 0.1 1.4 1 0 0 1 1 1 1 RNB domain Thymidylate_kin PF02223.12 ERZ95787.1 - 0.014 14.8 0.0 0.036 13.4 0.0 1.7 1 0 0 1 1 1 0 Thymidylate kinase DUF504 PF04457.7 ERZ95788.1 - 6.7e-06 26.1 3.9 2.3e-05 24.4 0.7 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF504) CAF-1_p150 PF11600.3 ERZ95788.1 - 0.11 11.8 16.2 0.19 11.0 11.2 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SprA-related PF12118.3 ERZ95788.1 - 0.23 10.7 7.7 0.27 10.5 5.3 1.1 1 0 0 1 1 1 0 SprA-related family CytochromB561_N PF09786.4 ERZ95788.1 - 0.65 8.3 12.2 0.83 8.0 8.5 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal PH PF00169.24 ERZ95789.1 - 3.5e-09 36.7 0.0 8.3e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 PH domain Cofilin_ADF PF00241.15 ERZ95789.1 - 5e-08 32.8 0.2 2.1e-07 30.8 0.0 2.1 3 0 0 3 3 3 1 Cofilin/tropomyosin-type actin-binding protein RR_TM4-6 PF06459.7 ERZ95789.1 - 0.0098 15.8 12.6 0.016 15.1 8.7 1.4 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CAF-1_p150 PF11600.3 ERZ95789.1 - 0.11 11.8 38.1 0.16 11.3 26.4 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal MAP7 PF05672.6 ERZ95789.1 - 0.94 8.8 47.1 1.5 8.2 32.6 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family CT47 PF15623.1 ERZ95789.1 - 2.5 7.7 27.4 4.1 7.0 19.0 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 Hid1 PF12722.2 ERZ95789.1 - 3.6 5.1 10.0 4.3 4.9 6.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Borrelia_P83 PF05262.6 ERZ95789.1 - 5.3 5.2 19.5 6.7 4.8 13.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MAD PF05557.8 ERZ95790.1 - 0.016 13.3 6.6 0.017 13.2 4.6 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF2097 PF09870.4 ERZ95790.1 - 0.074 13.1 1.0 0.083 12.9 0.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) Atg14 PF10186.4 ERZ95790.1 - 8.9 5.1 8.0 10 4.9 5.5 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 SPRY PF00622.23 ERZ95791.1 - 2.2e-08 34.2 0.3 3.6e-08 33.5 0.2 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ95791.1 - 2.3e-07 30.7 1.3 6e-07 29.4 0.2 2.2 2 0 0 2 2 2 1 BTB/POZ domain Vfa1 PF08432.5 ERZ95792.1 - 0.022 14.7 6.2 0.025 14.6 4.3 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 KIAA1430 PF13879.1 ERZ95792.1 - 0.023 15.1 2.0 2.7 8.4 1.2 2.1 2 0 0 2 2 2 0 KIAA1430 homologue Nucleo_P87 PF07267.6 ERZ95792.1 - 0.2 10.3 5.3 0.23 10.0 3.7 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MIP-T3 PF10243.4 ERZ95792.1 - 0.27 9.6 12.1 0.32 9.4 8.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 RR_TM4-6 PF06459.7 ERZ95792.1 - 0.42 10.4 4.5 0.48 10.2 3.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Adaptin_binding PF10199.4 ERZ95792.1 - 0.98 9.7 7.6 1.3 9.3 5.3 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 zf-RING_UBOX PF13445.1 ERZ95793.1 - 0.21 11.3 1.1 3.4 7.4 0.0 2.2 1 1 1 2 2 2 0 RING-type zinc-finger RIG-I_C-RD PF11648.3 ERZ95794.1 - 0.016 15.1 1.0 0.02 14.7 0.7 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I Tat PF00539.13 ERZ95794.1 - 1.9 8.1 4.9 5.4 6.7 3.4 1.8 1 1 0 1 1 1 0 Transactivating regulatory protein (Tat) DUF159 PF02586.9 ERZ95797.1 - 8.5e-58 195.3 0.3 1.4e-57 194.5 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, COG2135 Aldedh PF00171.17 ERZ95798.1 - 4.9e-177 588.9 0.0 5.4e-177 588.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ERZ95798.1 - 0.0005 19.3 0.0 0.0044 16.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) FoP_duplication PF13865.1 ERZ95799.1 - 0.0046 17.3 1.7 0.0068 16.8 0.0 2.1 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 p25-alpha PF05517.7 ERZ95799.1 - 0.056 13.7 2.1 0.075 13.2 0.1 2.0 1 1 1 2 2 2 0 p25-alpha p450 PF00067.17 ERZ95801.1 - 1.2e-86 291.0 2.4 1.6e-86 290.6 1.6 1.1 1 0 0 1 1 1 1 Cytochrome P450 MRC1 PF09444.5 ERZ95804.1 - 0.18 12.1 2.6 0.31 11.3 1.8 1.5 1 1 0 1 1 1 0 MRC1-like domain KCNQC3-Ank-G_bd PF11956.3 ERZ95805.1 - 0.018 15.0 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 NikR_C PF08753.6 ERZ95805.1 - 0.13 12.1 0.1 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 NikR C terminal nickel binding domain CENP-B_N PF04218.8 ERZ95807.1 - 4.2e-06 26.0 0.1 7.5e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain BrkDBD PF09607.5 ERZ95807.1 - 0.00023 20.6 0.1 0.00067 19.1 0.0 1.7 1 1 1 2 2 2 1 Brinker DNA-binding domain DUF1153 PF06627.6 ERZ95807.1 - 0.036 13.9 0.0 0.037 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) Methyltransf_11 PF08241.7 ERZ95808.1 - 1.6e-12 47.7 0.0 2.5e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ95808.1 - 1e-11 45.0 0.0 1.6e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ95808.1 - 1.9e-11 43.7 0.0 9.6e-11 41.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ95808.1 - 5.6e-11 42.4 0.0 6.5e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ95808.1 - 7.4e-08 32.9 0.0 2e-07 31.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ95808.1 - 3.6e-06 27.3 0.0 8.4e-06 26.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ERZ95808.1 - 2.7e-05 24.2 0.0 4.4e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 ERZ95808.1 - 6.6e-05 22.1 0.0 0.00018 20.7 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ERZ95808.1 - 6.7e-05 22.3 0.0 9.7e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ERZ95808.1 - 8.6e-05 21.6 0.0 0.00044 19.3 0.0 2.0 2 1 0 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 ERZ95808.1 - 0.00013 21.9 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ERZ95808.1 - 0.0043 16.2 0.0 0.011 14.9 0.0 1.6 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_29 PF03141.11 ERZ95808.1 - 0.067 11.5 0.0 0.29 9.4 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.15 ERZ95808.1 - 0.081 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.10 ERZ95808.1 - 0.13 11.9 0.0 0.27 10.8 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase RFC1 PF08519.7 ERZ95815.1 - 0.047 13.4 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Filament PF00038.16 ERZ95816.1 - 0.0022 17.5 14.8 0.0022 17.5 10.3 1.7 1 1 1 2 2 2 1 Intermediate filament protein Apolipoprotein PF01442.13 ERZ95816.1 - 0.017 14.6 12.6 0.022 14.2 8.7 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain EVC2_like PF12297.3 ERZ95816.1 - 0.017 13.7 9.8 0.036 12.6 6.6 1.7 1 1 0 1 1 1 0 Ellis van Creveld protein 2 like protein Prominin PF05478.6 ERZ95816.1 - 0.068 10.7 11.8 0.039 11.4 6.8 1.5 1 1 1 2 2 2 0 Prominin GM_CSF PF01109.12 ERZ95816.1 - 0.12 12.2 1.5 0.28 11.1 0.9 1.7 1 1 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Baculo_PEP_C PF04513.7 ERZ95816.1 - 0.14 11.9 9.1 7.2 6.4 6.0 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2359 PF10151.4 ERZ95816.1 - 0.15 10.6 3.0 4.1 5.8 0.1 2.1 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2359) Exonuc_VII_L PF02601.10 ERZ95816.1 - 0.18 10.9 12.7 0.29 10.2 8.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit BCDHK_Adom3 PF10436.4 ERZ95816.1 - 0.27 10.7 6.4 0.34 10.4 3.8 1.7 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Mer2 PF09074.5 ERZ95816.1 - 0.53 10.1 16.5 4.4 7.2 6.3 2.4 1 1 1 2 2 2 0 Mer2 DUF4358 PF14270.1 ERZ95816.1 - 0.57 10.0 16.7 3 7.7 2.1 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4358) Phasin PF05597.6 ERZ95816.1 - 0.66 9.7 16.6 0.61 9.8 1.7 2.7 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) IncA PF04156.9 ERZ95816.1 - 0.68 9.4 17.9 2.8 7.4 12.5 2.0 1 1 0 1 1 1 0 IncA protein Fib_alpha PF08702.5 ERZ95816.1 - 0.89 9.6 20.3 0.47 10.5 10.0 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1548 PF07579.6 ERZ95816.1 - 1.4 9.0 7.5 1.2 9.1 1.0 2.4 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1548) PhoU_div PF01865.11 ERZ95816.1 - 1.5 7.9 12.8 2.4 7.2 5.0 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF47 ZYG-11_interact PF05884.7 ERZ95816.1 - 1.8 7.6 9.0 8.3 5.3 3.0 2.3 1 1 1 2 2 2 0 Interactor of ZYG-11 HSCB_C PF07743.8 ERZ95816.1 - 2.3 8.7 13.9 2.6 8.5 2.9 3.0 2 1 2 4 4 3 0 HSCB C-terminal oligomerisation domain DUF464 PF04327.7 ERZ95816.1 - 3 8.1 9.0 0.93 9.7 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF464) DUF2756 PF10956.3 ERZ95816.1 - 7.6 6.8 13.5 11 6.3 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) UCH PF00443.24 ERZ95816.1 - 9 5.3 7.9 11 4.9 5.5 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase RNA_ligase PF09414.5 ERZ95817.1 - 9.4e-27 93.9 0.0 2.2e-26 92.7 0.0 1.6 1 1 0 1 1 1 1 RNA ligase Stork_head PF10264.4 ERZ95817.1 - 0.12 12.6 0.2 0.65 10.2 0.1 2.0 1 1 1 2 2 2 0 Winged helix Storkhead-box1 domain Pkinase PF00069.20 ERZ95819.1 - 1e-48 165.8 0.5 1.8e-48 164.9 0.0 1.5 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95819.1 - 3.2e-41 141.1 0.0 4e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ERZ95819.1 - 0.003 16.9 0.0 0.0048 16.2 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ95819.1 - 0.0031 16.6 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ95819.1 - 0.12 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family BMC PF00936.14 ERZ95821.1 - 0.024 14.3 0.1 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 BMC domain NESP55 PF06390.7 ERZ95821.1 - 0.54 9.5 5.1 0.82 8.9 3.6 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DZR PF12773.2 ERZ95821.1 - 2.3 8.0 11.4 7.4 6.4 8.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon DUF4224 PF13986.1 ERZ95822.1 - 0.078 12.5 0.0 0.94 9.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) DUF608 PF04685.8 ERZ95824.1 - 0.08 11.6 0.0 0.08 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF608 Dimer_Tnp_hAT PF05699.9 ERZ95825.1 - 1.5e-05 24.5 0.2 2.6e-05 23.7 0.1 1.5 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Saw1 PF11561.3 ERZ95825.1 - 0.026 13.8 1.7 0.033 13.5 1.2 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Kdo_hydroxy PF11004.3 ERZ95825.1 - 0.11 11.4 0.1 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase RelB_N PF12910.2 ERZ95825.1 - 0.16 11.3 0.2 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin stability system N-terminal Sp38 PF07354.7 ERZ95826.1 - 0.0023 16.6 2.4 0.0035 16.0 1.7 1.3 1 0 0 1 1 1 1 Zona-pellucida-binding protein (Sp38) Shugoshin_N PF07558.6 ERZ95826.1 - 0.45 10.2 9.1 0.073 12.7 3.3 2.0 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region LMP PF04778.7 ERZ95827.1 - 0.12 12.1 1.9 0.13 12.0 1.3 1.2 1 0 0 1 1 1 0 LMP repeated region zf-BED PF02892.10 ERZ95828.1 - 7.6e-07 28.7 1.2 1.4e-06 27.9 0.8 1.4 1 0 0 1 1 1 1 BED zinc finger zf-CCHC PF00098.18 ERZ95828.1 - 0.13 12.2 0.6 13 5.8 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle Dimer_Tnp_hAT PF05699.9 ERZ95829.1 - 0.0022 17.5 0.0 0.0062 16.1 0.0 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-BED PF02892.10 ERZ95830.1 - 7.3e-07 28.8 1.2 1.3e-06 28.0 0.8 1.4 1 0 0 1 1 1 1 BED zinc finger zf-CCHC PF00098.18 ERZ95830.1 - 0.12 12.3 0.6 13 5.9 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle Dimer_Tnp_hAT PF05699.9 ERZ95831.1 - 0.0019 17.7 0.1 0.0019 17.7 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TFIIE-A_C-term PF11521.3 ERZ95833.1 - 0.098 12.6 2.4 0.13 12.2 1.1 1.6 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Elongin_A PF06881.6 ERZ95833.1 - 1.2 9.5 7.2 0.19 12.0 1.3 2.3 2 2 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF2373 PF10180.4 ERZ95837.1 - 0.48 9.9 2.7 0.66 9.5 1.8 1.6 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) PyrI_C PF02748.10 ERZ95838.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain BTB PF00651.26 ERZ95839.1 - 1.1e-14 54.3 0.0 2.4e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ95839.1 - 1e-13 51.4 0.6 2.2e-13 50.4 0.4 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ95839.1 - 1.1e-13 50.8 2.8 1.1e-09 37.9 0.2 3.3 3 0 0 3 3 3 2 BTB And C-terminal Kelch Glyco_hydro_62 PF03664.8 ERZ95839.1 - 0.039 13.0 0.0 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 62 Sel1 PF08238.7 ERZ95840.1 - 5.1e-77 252.6 42.3 6.3e-12 45.7 0.8 8.9 9 0 0 9 9 9 8 Sel1 repeat MIT PF04212.13 ERZ95840.1 - 4.1e-06 26.5 21.2 0.7 9.8 0.1 6.6 5 1 2 7 7 7 3 MIT (microtubule interacting and transport) domain NUMOD1 PF07453.8 ERZ95840.1 - 0.0012 18.5 2.0 98 3.0 0.0 6.3 7 0 0 7 7 7 0 NUMOD1 domain TPR_20 PF14561.1 ERZ95840.1 - 0.0017 18.4 4.6 5.1 7.2 0.0 4.8 2 2 4 6 6 6 2 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ERZ95840.1 - 0.0032 17.1 1.1 34 4.2 0.0 4.9 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation DUF892 PF05974.7 ERZ95840.1 - 0.0038 17.0 3.5 0.021 14.6 0.6 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF892) ELYS PF13934.1 ERZ95840.1 - 0.0055 16.4 0.5 5.1 6.7 0.0 3.3 2 1 2 4 4 4 2 Nuclear pore complex assembly zf-GRF PF06839.7 ERZ95840.1 - 0.014 15.2 18.8 10 6.1 0.0 6.6 8 0 0 8 8 8 0 GRF zinc finger Flu_M1_C PF08289.6 ERZ95840.1 - 0.036 14.0 0.0 1.6e+02 2.4 0.0 4.5 1 1 2 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain CitT PF12431.3 ERZ95840.1 - 0.11 12.6 0.0 1.4e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 Transcriptional regulator ssDNA-exonuc_C PF10141.4 ERZ95840.1 - 0.13 11.7 4.6 2.8 7.3 0.0 3.2 3 0 0 3 3 3 0 Single-strand DNA-specific exonuclease, C terminal domain Spo0A_C PF08769.6 ERZ95840.1 - 0.16 11.8 0.8 15 5.4 0.0 3.5 1 1 3 4 4 4 0 Sporulation initiation factor Spo0A C terminal TatD_DNase PF01026.16 ERZ95840.1 - 0.89 8.7 4.5 14 4.8 3.1 2.7 1 1 0 1 1 1 0 TatD related DNase TPR_16 PF13432.1 ERZ95840.1 - 2.2 9.0 10.9 6.7 7.5 0.3 4.6 3 3 2 5 5 5 0 Tetratricopeptide repeat Prenyltrans_1 PF13243.1 ERZ95840.1 - 4.8 7.2 9.7 77 3.3 0.1 4.3 1 1 3 4 4 4 0 Prenyltransferase-like zf-Di19 PF05605.7 ERZ95841.1 - 0.036 14.1 1.5 0.075 13.1 1.0 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ERZ95841.1 - 0.1 13.0 1.2 0.2 12.0 0.8 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ERZ95841.1 - 0.21 11.5 4.4 0.5 10.3 3.0 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger MNSV_P7B PF06692.6 ERZ95843.1 - 0.39 10.5 2.8 2.4 8.0 0.1 2.7 3 0 0 3 3 3 0 Melon necrotic spot virus P7B protein F-box-like PF12937.2 ERZ95844.1 - 9.6e-06 25.2 0.1 6.5e-05 22.5 0.0 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 ERZ95844.1 - 0.0002 20.9 0.0 0.00052 19.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain VWA_2 PF13519.1 ERZ95845.1 - 4.8e-08 33.2 0.1 7.1e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ERZ95845.1 - 7.1e-05 22.5 0.4 0.00013 21.6 0.3 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.4 ERZ95845.1 - 0.0064 16.4 0.1 0.1 12.6 0.0 2.1 1 1 1 2 2 2 1 VWA-like domain (DUF2201) OmpW PF03922.9 ERZ95846.1 - 0.064 12.9 0.2 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 OmpW family BOP1NT PF08145.7 ERZ95847.1 - 0.00076 19.2 2.4 0.00098 18.9 1.7 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain UPF0054 PF02130.12 ERZ95848.1 - 0.082 12.1 0.2 0.13 11.4 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein family UPF0054 Self-incomp_S1 PF05938.6 ERZ95848.1 - 0.5 10.4 4.8 0.3 11.1 1.3 2.0 2 0 0 2 2 2 0 Plant self-incompatibility protein S1 V_ATPase_I PF01496.14 ERZ95849.1 - 0.0029 15.5 5.7 0.0036 15.2 4.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4446 PF14584.1 ERZ95849.1 - 0.0072 16.1 3.6 0.015 15.1 2.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) Glyco_hydro_14 PF01373.12 ERZ95849.1 - 0.012 14.3 0.1 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 DUF3510 PF12022.3 ERZ95849.1 - 0.09 12.8 9.3 0.22 11.6 1.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) GLE1 PF07817.8 ERZ95849.1 - 0.27 10.1 4.6 0.45 9.4 3.2 1.3 1 0 0 1 1 1 0 GLE1-like protein Med28 PF11594.3 ERZ95849.1 - 0.38 11.0 7.7 1.2 9.4 5.3 1.8 1 1 1 2 2 2 0 Mediator complex subunit 28 LMBR1 PF04791.11 ERZ95849.1 - 0.69 8.4 3.4 0.79 8.2 2.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Activator_LAG-3 PF11498.3 ERZ95849.1 - 0.89 8.2 7.5 1.3 7.6 5.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 YgaB PF14182.1 ERZ95849.1 - 2.5 8.3 9.7 2.8 8.2 4.5 2.4 2 0 0 2 2 2 0 YgaB-like protein DUF972 PF06156.8 ERZ95849.1 - 6.1 7.2 14.1 0.69 10.2 2.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF972) SH3_2 PF07653.12 ERZ95850.1 - 0.00012 21.4 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain YjcQ PF09639.5 ERZ95851.1 - 0.02 14.9 0.4 0.02 14.9 0.3 1.6 2 0 0 2 2 2 0 YjcQ protein Peptidase_U57 PF05582.7 ERZ95851.1 - 0.1 11.5 0.4 0.1 11.5 0.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Dimer_Tnp_hAT PF05699.9 ERZ95852.1 - 5.8e-20 70.7 0.1 6.3e-20 70.5 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3278 PF11683.3 ERZ95853.1 - 0.06 13.3 1.0 0.076 13.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) S-antigen PF05756.6 ERZ95853.1 - 0.48 10.4 2.0 0.72 9.8 1.4 1.3 1 0 0 1 1 1 0 S-antigen protein B2-adapt-app_C PF09066.5 ERZ95854.1 - 0.0084 15.9 1.5 0.016 15.0 0.4 2.0 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain PRF PF06875.6 ERZ95854.1 - 0.011 14.9 0.3 0.013 14.7 0.2 1.1 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF RTC4 PF14474.1 ERZ95855.1 - 4.1e-07 29.9 0.0 7e-07 29.2 0.0 1.6 1 1 0 1 1 1 1 RTC4-like domain zf-CHCC PF10276.4 ERZ95855.1 - 0.016 15.0 0.3 0.027 14.2 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger domain Cys_rich_CPXG PF14255.1 ERZ95855.1 - 0.075 12.8 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Cysteine-rich CPXCG E1_DerP2_DerF2 PF02221.10 ERZ95856.1 - 0.0011 19.2 0.0 0.0011 19.1 0.0 1.1 1 0 0 1 1 1 1 ML domain RTC4 PF14474.1 ERZ95857.1 - 0.00022 21.1 0.0 0.00024 21.0 0.0 1.1 1 0 0 1 1 1 1 RTC4-like domain DUF3684 PF12449.3 ERZ95858.1 - 2.3e-70 237.4 0.8 1.2e-69 235.1 0.6 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3684) WLM PF08325.5 ERZ95858.1 - 0.037 13.8 0.6 0.087 12.6 0.4 1.5 1 0 0 1 1 1 0 WLM domain Peptidase_M10 PF00413.19 ERZ95858.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Matrixin Con-6 PF10346.4 ERZ95859.1 - 0.0001 21.6 1.3 0.00019 20.7 0.9 1.5 1 0 0 1 1 1 1 Conidiation protein 6 DUF3752 PF12572.3 ERZ95859.1 - 1.1 9.3 10.1 1.3 9.1 7.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Ribosomal_S13 PF00416.17 ERZ95860.1 - 7.4e-41 138.9 1.3 9e-41 138.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 ERZ95860.1 - 0.0021 16.6 0.0 0.0024 16.5 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) PP28 PF10252.4 ERZ95860.1 - 0.013 15.4 1.4 0.023 14.6 0.5 1.8 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 DUF1822 PF08852.6 ERZ95860.1 - 0.046 12.5 0.0 0.062 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) HHH_6 PF14579.1 ERZ95860.1 - 0.11 12.5 0.1 0.31 11.1 0.1 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif Myb_DNA-binding PF00249.26 ERZ95861.1 - 6.1e-37 125.4 10.7 1.7e-12 47.2 0.2 3.7 4 0 0 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ95861.1 - 3.3e-35 119.9 10.3 7.8e-15 54.7 0.7 3.7 1 1 2 3 3 3 3 Myb-like DNA-binding domain zf-C2H2_4 PF13894.1 ERZ95861.1 - 1.3e-10 40.8 9.0 0.073 13.4 0.6 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.21 ERZ95861.1 - 5.3e-07 29.6 11.8 0.15 12.4 1.4 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type Rap1_C PF11626.3 ERZ95861.1 - 0.0094 15.8 4.9 0.53 10.2 0.8 3.5 1 1 1 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain zf-Di19 PF05605.7 ERZ95861.1 - 0.032 14.3 7.3 3.9 7.6 0.1 3.6 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Tmemb_170 PF10190.4 ERZ95862.1 - 0.00039 20.4 11.9 0.00042 20.3 8.2 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 ATP_synt_H PF05493.8 ERZ95862.1 - 0.45 10.6 7.0 1.8 8.7 4.9 2.3 1 1 0 1 1 1 0 ATP synthase subunit H DUF1129 PF06570.6 ERZ95862.1 - 2.3 7.4 11.1 2.5 7.3 7.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) ING PF12998.2 ERZ95863.1 - 1.7e-21 76.4 1.9 1.7e-21 76.4 1.3 2.5 2 1 0 2 2 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 ERZ95863.1 - 1e-08 34.7 11.2 2e-08 33.8 7.8 1.5 1 0 0 1 1 1 1 PHD-finger MMR1 PF08505.5 ERZ95863.1 - 0.0015 18.6 10.6 0.0018 18.3 7.3 1.2 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein Menin PF05053.8 ERZ95863.1 - 0.018 13.2 8.9 0.02 13.0 6.1 1.1 1 0 0 1 1 1 0 Menin zf-RING-like PF08746.6 ERZ95863.1 - 0.12 12.3 7.4 0.22 11.5 5.1 1.4 1 0 0 1 1 1 0 RING-like domain DUF29 PF01724.11 ERZ95863.1 - 0.12 12.1 4.2 0.084 12.7 1.6 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF29 Asp-B-Hydro_N PF05279.6 ERZ95863.1 - 0.86 9.4 15.6 1.1 9.0 10.8 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region MDFI PF15316.1 ERZ95863.1 - 1.1 9.1 8.3 1.9 8.4 5.8 1.4 1 0 0 1 1 1 0 MyoD family inhibitor FancD2 PF14631.1 ERZ95863.1 - 2.8 4.9 7.6 3.3 4.6 5.3 1.3 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Suf PF05843.9 ERZ95863.1 - 7.7 6.1 14.8 13 5.4 10.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF1510 PF07423.6 ERZ95863.1 - 9.9 5.4 26.2 16 4.8 18.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Cpn60_TCP1 PF00118.19 ERZ95864.1 - 3.5e-152 507.4 3.7 4e-152 507.2 2.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EFP_N PF08207.7 ERZ95867.1 - 2.7e-11 43.1 1.2 5.1e-11 42.2 0.9 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Elong-fact-P_C PF09285.6 ERZ95867.1 - 6.3e-09 35.0 2.5 6.8e-09 34.9 0.6 1.9 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP PF01132.15 ERZ95867.1 - 3e-08 33.2 2.4 5.9e-08 32.2 1.7 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain eIF-1a PF01176.14 ERZ95867.1 - 0.1 12.0 0.4 10 5.6 0.0 2.8 3 0 0 3 3 3 0 Translation initiation factor 1A / IF-1 DUF2072 PF09845.4 ERZ95868.1 - 0.00049 20.0 0.5 0.00091 19.1 0.4 1.4 1 0 0 1 1 1 1 Zn-ribbon containing protein (DUF2072) HR1 PF02185.11 ERZ95868.1 - 0.069 12.9 2.2 0.15 11.8 1.5 1.6 1 0 0 1 1 1 0 Hr1 repeat Spc7 PF08317.6 ERZ95868.1 - 0.094 11.3 0.6 0.18 10.4 0.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein ATG16 PF08614.6 ERZ95868.1 - 0.13 12.0 3.8 0.21 11.3 2.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DivIC PF04977.10 ERZ95868.1 - 0.56 9.7 4.7 0.42 10.1 2.0 1.7 2 0 0 2 2 2 0 Septum formation initiator DUF2870 PF11069.3 ERZ95868.1 - 0.99 9.4 3.4 24 5.0 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2870) UPF0020 PF01170.13 ERZ95870.1 - 0.014 15.0 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Pkinase PF00069.20 ERZ95871.1 - 1.6e-25 89.7 0.0 2.8e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95871.1 - 1.8e-24 86.2 0.0 2.8e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ95871.1 - 0.0065 16.2 0.1 0.013 15.2 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ95871.1 - 0.01 15.0 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ERZ95871.1 - 0.017 14.1 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ERZ95871.1 - 0.041 13.2 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 RIO1 family FMO-like PF00743.14 ERZ95873.1 - 0.08 11.1 0.1 0.079 11.1 0.1 1.0 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like BCS1_N PF08740.6 ERZ95874.1 - 0.058 13.0 0.1 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 BCS1 N terminal PUF PF00806.14 ERZ95874.1 - 0.098 12.1 0.1 0.42 10.1 0.0 2.1 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Phage_XkdX PF09693.5 ERZ95874.1 - 0.89 9.1 7.4 0.28 10.7 0.3 2.5 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) CDT1 PF08839.6 ERZ95876.1 - 0.022 14.6 0.1 0.038 13.9 0.1 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like DUF1027 PF06265.6 ERZ95878.1 - 0.071 12.9 1.4 0.18 11.6 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1027) DUF1722 PF08349.6 ERZ95878.1 - 0.093 12.6 0.1 0.23 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1722) GGDEF PF00990.16 ERZ95879.1 - 9.6e-21 74.0 0.1 1.6e-20 73.3 0.1 1.4 1 0 0 1 1 1 1 GGDEF domain FHA PF00498.21 ERZ95879.1 - 3e-12 46.4 0.1 7e-12 45.3 0.1 1.7 1 0 0 1 1 1 1 FHA domain Pkinase_Tyr PF07714.12 ERZ95879.1 - 1.4e-11 44.0 0.2 2.1e-09 36.8 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ95879.1 - 7.8e-09 35.0 0.9 6.1e-07 28.8 0.6 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase PF00069.20 ERZ95880.1 - 6.2e-50 169.7 0.1 7.9e-50 169.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95880.1 - 2.8e-42 144.5 0.0 3.6e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ERZ95880.1 - 9e-05 21.8 0.1 0.00014 21.2 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ95880.1 - 0.002 17.2 0.1 0.0033 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ95880.1 - 0.0023 17.3 0.3 0.0023 17.3 0.2 1.8 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ERZ95880.1 - 0.0048 16.6 0.0 0.011 15.5 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ95880.1 - 0.011 14.9 3.4 0.018 14.2 2.4 1.5 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ERZ95880.1 - 0.026 13.4 0.0 0.085 11.8 0.0 1.7 2 0 0 2 2 2 0 Kinase-like DNA_pol_B_exo1 PF03104.14 ERZ95881.1 - 1.8e-18 66.5 2.9 7.2e-18 64.5 2.0 1.8 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain Sel1 PF08238.7 ERZ95882.1 - 8.1e-127 410.9 41.6 4.1e-09 36.7 0.1 14.1 14 0 0 14 14 14 14 Sel1 repeat MIT PF04212.13 ERZ95882.1 - 1.8e-05 24.5 55.9 0.26 11.1 1.1 10.7 5 3 7 12 12 12 9 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ERZ95882.1 - 9.7e-05 22.2 54.1 0.28 11.1 0.7 11.5 3 3 9 12 12 12 6 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ95882.1 - 0.062 13.9 8.3 0.38 11.4 0.5 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ95882.1 - 0.21 12.1 30.2 16 6.2 0.0 11.5 14 0 0 14 14 14 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.19 ERZ95882.1 - 0.37 10.8 8.6 16 5.6 0.1 5.8 5 2 1 7 7 7 0 Acetyltransferase (GNAT) family RXT2_N PF08595.6 ERZ95883.1 - 0.25 11.1 3.8 0.26 11.0 2.7 1.0 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF3952 PF13130.1 ERZ95883.1 - 1.6 8.7 5.6 2 8.4 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3952) DUF809 PF05663.6 ERZ95884.1 - 0.62 9.9 2.3 0.69 9.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF809) DEAD PF00270.24 ERZ95886.1 - 5.1e-42 143.2 0.9 8.7e-42 142.4 0.3 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ95886.1 - 2.4e-27 94.5 0.4 6.5e-27 93.2 0.2 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ERZ95886.1 - 0.00017 21.5 0.1 0.00059 19.7 0.1 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 ERZ95886.1 - 0.0028 17.2 0.0 0.0073 15.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ERZ95886.1 - 0.0099 15.6 0.0 0.03 14.0 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain CMS1 PF14617.1 ERZ95886.1 - 0.017 14.2 0.0 0.042 12.9 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.9 ERZ95886.1 - 0.022 14.3 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Helicase UvrD-helicase PF00580.16 ERZ95886.1 - 0.046 13.0 0.0 0.054 12.7 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain SNF2_N PF00176.18 ERZ95886.1 - 0.074 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 ERZ95886.1 - 0.076 12.7 0.1 0.26 11.0 0.0 2.1 1 1 0 1 1 1 0 Flavivirus DEAD domain Arm PF00514.18 ERZ95887.1 - 4.3e-34 115.1 0.1 3.6e-06 26.5 0.0 7.0 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ERZ95887.1 - 5.8e-14 52.1 0.0 0.00064 19.9 0.0 5.2 3 3 1 4 4 4 4 HEAT repeats HEAT_EZ PF13513.1 ERZ95887.1 - 3e-10 40.2 0.0 0.00041 20.7 0.0 5.4 5 1 2 7 7 7 1 HEAT-like repeat HEAT PF02985.17 ERZ95887.1 - 9.5e-06 25.2 0.2 36 4.8 0.0 6.1 6 0 0 6 6 6 0 HEAT repeat IBB PF01749.15 ERZ95887.1 - 2.8e-05 24.1 4.9 6.9e-05 22.9 3.4 1.6 1 0 0 1 1 1 1 Importin beta binding domain RICTOR_V PF14668.1 ERZ95887.1 - 0.0039 17.0 0.0 0.97 9.4 0.0 3.6 2 2 2 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 Proteasom_PSMB PF10508.4 ERZ95887.1 - 0.0089 14.3 0.2 0.032 12.4 0.0 1.9 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit HEAT_PBS PF03130.11 ERZ95887.1 - 0.041 14.3 0.2 7.8 7.2 0.0 4.1 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Pribosyltran_N PF13793.1 ERZ95888.1 - 3.5e-49 165.3 1.5 4.9e-46 155.2 0.2 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ERZ95888.1 - 1e-47 162.3 3.5 8.4e-40 136.4 1.0 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ERZ95888.1 - 1.4e-13 50.6 0.4 9.9e-13 47.9 0.1 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ERZ95888.1 - 0.00068 18.9 0.2 0.0012 18.1 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PduV-EutP PF10662.4 ERZ95888.1 - 0.063 12.7 0.2 36 3.8 0.0 3.3 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_DE_N PF02823.11 ERZ95888.1 - 0.12 12.1 1.2 1.8 8.3 0.0 2.7 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain F-box-like PF12937.2 ERZ95891.1 - 1.8e-07 30.7 0.2 2.2e-06 27.2 0.0 2.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ95891.1 - 0.6 9.8 0.0 0.6 9.8 0.0 3.5 4 0 0 4 4 4 0 F-box domain Ifi-6-16 PF06140.8 ERZ95894.1 - 3.3e-12 46.0 21.8 5.6e-12 45.2 14.5 1.9 1 1 1 2 2 2 1 Interferon-induced 6-16 family M16C_assoc PF08367.6 ERZ95895.1 - 2.5e-71 239.4 7.8 5.5e-71 238.3 5.4 1.6 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 ERZ95895.1 - 3.3e-33 114.9 1.7 4.9e-18 65.4 0.3 3.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ERZ95895.1 - 0.031 14.0 0.2 4.4 7.0 0.0 4.0 5 0 0 5 5 5 0 Insulinase (Peptidase family M16) Sec-ASP3 PF15432.1 ERZ95897.1 - 0.014 15.3 1.8 0.087 12.7 0.0 2.6 2 1 0 2 2 2 0 Accessory Sec secretory system ASP3 Pkinase PF00069.20 ERZ95898.1 - 1.3e-52 178.5 0.1 1.7e-52 178.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ95898.1 - 7.4e-47 159.5 0.0 1.1e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ95898.1 - 3.3e-05 23.7 0.2 0.007 16.1 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ERZ95898.1 - 0.00012 21.4 0.1 0.00022 20.6 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ERZ95898.1 - 0.011 15.1 2.4 0.034 13.4 1.7 1.9 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.9 ERZ95898.1 - 0.043 12.8 0.3 0.07 12.1 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ95898.1 - 0.12 11.2 0.0 0.47 9.3 0.0 1.8 2 1 0 2 2 2 0 Kinase-like DnaB_bind PF10410.4 ERZ95899.1 - 0.055 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase DUF1764 PF08576.5 ERZ95899.1 - 3.4 8.4 5.7 2.9 8.7 2.1 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Sel1 PF08238.7 ERZ95900.1 - 1.2e-15 57.5 1.3 0.00054 20.5 0.0 3.2 3 0 0 3 3 3 3 Sel1 repeat MMtag PF10159.4 ERZ95900.1 - 0.3 11.1 1.4 6.1 6.9 0.1 2.1 1 1 1 2 2 2 0 Kinase phosphorylation protein DNA_pol_B_exo1 PF03104.14 ERZ95903.1 - 8.4e-19 67.5 1.3 1.2e-18 67.0 0.9 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain RNase_H_2 PF13482.1 ERZ95903.1 - 0.008 16.0 0.6 0.017 14.9 0.4 1.7 1 1 0 1 1 1 1 RNase_H superfamily PLDc_N PF13396.1 ERZ95907.1 - 0.07 12.8 0.4 0.07 12.8 0.3 2.5 2 0 0 2 2 2 0 Phospholipase_D-nuclease N-terminal WW PF00397.21 ERZ95908.1 - 2.7e-11 43.1 4.3 3.8e-11 42.6 3.0 1.2 1 0 0 1 1 1 1 WW domain TFIIA PF03153.8 ERZ95908.1 - 0.21 11.4 30.3 0.25 11.1 21.0 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2486 PF10667.4 ERZ95908.1 - 0.24 11.9 5.9 0.28 11.6 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) YejG PF13989.1 ERZ95908.1 - 0.3 11.1 7.4 0.4 10.7 5.2 1.1 1 0 0 1 1 1 0 YejG-like protein DUF2347 PF09804.4 ERZ95908.1 - 0.46 9.7 10.1 0.58 9.3 7.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF4045 PF13254.1 ERZ95908.1 - 0.78 8.9 10.3 0.87 8.8 7.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) IncA PF04156.9 ERZ95908.1 - 1.5 8.3 26.7 1.8 8.0 18.5 1.1 1 0 0 1 1 1 0 IncA protein Tho2 PF11262.3 ERZ95908.1 - 1.7 7.5 19.7 2.4 7.1 13.7 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 HSP70 PF00012.15 ERZ95908.1 - 1.9 6.3 14.3 2.1 6.1 9.9 1.0 1 0 0 1 1 1 0 Hsp70 protein AAA_23 PF13476.1 ERZ95908.1 - 2.3 8.5 20.0 2.9 8.1 13.9 1.2 1 0 0 1 1 1 0 AAA domain Dna2 PF08696.6 ERZ95908.1 - 2.5 7.3 11.7 3.6 6.8 8.1 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 DUF883 PF05957.8 ERZ95908.1 - 2.7 8.4 10.1 4.1 7.8 7.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Mgr1 PF08602.5 ERZ95908.1 - 3.2 6.6 10.9 3.9 6.3 7.5 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit ERCC4 PF02732.10 ERZ95908.1 - 3.3 7.4 11.3 5.1 6.8 7.8 1.3 1 0 0 1 1 1 0 ERCC4 domain Het-C PF07217.6 ERZ95908.1 - 3.4 5.7 17.2 3.9 5.5 11.9 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Peptidase_S15 PF02129.13 ERZ95908.1 - 4.6 6.5 8.8 5.3 6.3 6.1 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) DUF3708 PF12501.3 ERZ95908.1 - 4.7 7.0 7.8 6.2 6.6 5.4 1.1 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter GBP_C PF02841.9 ERZ95908.1 - 8.4 5.4 30.5 11 5.0 21.1 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain GldM_C PF12080.3 ERZ95908.1 - 8.9 6.2 9.6 12 5.7 6.6 1.1 1 0 0 1 1 1 0 GldM C-terminal domain V_ATPase_I PF01496.14 ERZ95908.1 - 8.9 4.0 14.6 10 3.8 10.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Asp-B-Hydro_N PF05279.6 ERZ95908.1 - 9.1 6.0 12.6 11 5.7 8.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CemA PF03040.9 ERZ95908.1 - 9.6 5.7 15.5 12 5.4 10.8 1.1 1 0 0 1 1 1 0 CemA family DUF342 PF03961.8 ERZ95908.1 - 9.6 4.4 18.8 12 4.1 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4220 PF13968.1 ERZ95908.1 - 10 5.1 11.3 13 4.8 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) SAM_1 PF00536.25 ERZ95909.1 - 0.033 14.3 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) LEM PF03020.10 ERZ95909.1 - 0.12 11.8 0.1 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 LEM domain YfmQ PF10787.4 ERZ95911.1 - 0.065 12.5 0.5 0.49 9.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein from bacillus cereus group DUF2524 PF10732.4 ERZ95913.1 - 0.067 13.3 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) Jacalin PF01419.12 ERZ95914.1 - 0.0088 15.9 0.2 0.01 15.7 0.1 1.3 1 1 0 1 1 1 1 Jacalin-like lectin domain Kinetocho_Slk19 PF12709.2 ERZ95916.1 - 0.028 14.4 1.3 0.039 14.0 0.9 1.2 1 0 0 1 1 1 0 Central kinetochore-associated Leu_Phe_trans PF03588.9 ERZ95916.1 - 0.051 12.7 0.2 0.062 12.4 0.1 1.2 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase SF-assemblin PF06705.6 ERZ95916.1 - 0.12 11.4 0.6 0.28 10.3 0.4 1.5 1 1 0 1 1 1 0 SF-assemblin/beta giardin BTB PF00651.26 ERZ95917.1 - 1.3e-19 70.1 0.8 5e-19 68.3 0.0 2.2 3 0 0 3 3 3 1 BTB/POZ domain Skp1_POZ PF03931.10 ERZ95917.1 - 0.00067 19.7 0.5 0.0017 18.4 0.1 1.9 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain FANCI_S4 PF14678.1 ERZ95918.1 - 0.0064 15.6 2.1 0.0069 15.5 1.5 1.0 1 0 0 1 1 1 1 FANCI solenoid 4 DUF908 PF06012.7 ERZ95918.1 - 0.05 12.9 0.4 0.058 12.6 0.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Limkain-b1 PF11608.3 ERZ95918.1 - 0.12 12.1 0.2 0.17 11.6 0.1 1.4 1 1 0 1 1 1 0 Limkain b1 DUF2951 PF11166.3 ERZ95918.1 - 9.3 6.1 8.5 23 4.9 5.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) AAA_35 PF14516.1 ERZ95919.1 - 4.5e-08 32.1 0.0 6.8e-08 31.5 0.0 1.3 1 1 0 1 1 1 1 AAA-like domain Arch_ATPase PF01637.13 ERZ95919.1 - 2.8e-06 27.2 0.3 3.8e-06 26.7 0.2 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ERZ95919.1 - 0.0011 18.9 0.2 0.0069 16.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ95919.1 - 0.038 14.2 0.0 0.094 12.9 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_P18 PF04521.8 ERZ95922.1 - 0.0078 15.6 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 ssRNA positive strand viral 18kD cysteine rich protein zf-CSL PF05207.8 ERZ95923.1 - 0.02 14.3 0.1 0.043 13.3 0.1 1.6 1 0 0 1 1 1 0 CSL zinc finger Syntaxin PF00804.20 ERZ95923.1 - 6.9 6.9 7.0 48 4.1 4.9 2.3 1 1 0 1 1 1 0 Syntaxin DUF1199 PF06712.6 ERZ95926.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1199) ApbA_C PF08546.6 ERZ95927.1 - 6.7e-17 61.6 0.0 4.7e-16 58.9 0.0 2.3 2 1 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 ERZ95927.1 - 1.7e-15 56.7 0.1 1.6e-14 53.5 0.1 2.1 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 ERZ95927.1 - 8.9e-07 28.7 0.4 1.2e-05 25.1 0.3 2.3 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 ERZ95927.1 - 8.5e-06 26.1 0.2 0.087 13.2 0.0 2.4 1 1 1 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent TFIIE_beta PF02186.10 ERZ95927.1 - 0.089 12.8 2.4 0.31 11.0 1.7 2.0 1 0 0 1 1 1 0 TFIIE beta subunit core domain TrkA_N PF02254.13 ERZ95927.1 - 0.14 12.1 2.2 2.3 8.2 0.1 2.4 1 1 1 2 2 2 0 TrkA-N domain bZIP_1 PF00170.16 ERZ95928.1 - 2.3e-11 43.4 8.9 2.3e-11 43.4 6.2 2.2 1 1 1 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 ERZ95928.1 - 9.6e-10 38.1 8.1 9.6e-10 38.1 5.6 2.3 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 ERZ95928.1 - 0.0068 16.6 6.1 0.0075 16.5 3.1 1.9 1 1 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.13 ERZ95928.1 - 0.33 10.7 3.4 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Macoilin PF09726.4 ERZ95928.1 - 2.4 6.3 19.5 5.1 5.2 13.5 1.4 1 1 0 1 1 1 0 Transmembrane protein DUF1664 PF07889.7 ERZ95928.1 - 4.3 7.1 6.7 1.3 8.8 1.4 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) F-box-like PF12937.2 ERZ95929.1 - 4.5e-05 23.0 2.2 0.00024 20.7 1.4 2.4 2 0 0 2 2 2 1 F-box-like Imm44 PF15584.1 ERZ95929.1 - 0.079 12.8 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 44 BTB PF00651.26 ERZ95930.1 - 2.9e-18 65.8 3.6 2.4e-17 62.8 0.1 2.3 2 0 0 2 2 2 2 BTB/POZ domain SPRY PF00622.23 ERZ95930.1 - 3.5e-08 33.5 0.6 6e-08 32.8 0.4 1.3 1 0 0 1 1 1 1 SPRY domain NRDD PF13597.1 ERZ95936.1 - 0.011 13.8 0.0 0.013 13.5 0.0 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase zf-UDP PF14569.1 ERZ95936.1 - 0.17 11.6 2.5 4 7.2 0.5 2.2 1 1 0 2 2 2 0 Zinc-binding RING-finger bZIP_1 PF00170.16 ERZ95938.1 - 0.00041 20.2 11.2 0.067 13.1 0.2 2.8 1 1 1 2 2 2 2 bZIP transcription factor DivIC PF04977.10 ERZ95938.1 - 0.0012 18.2 11.5 0.079 12.4 0.8 2.9 1 1 1 2 2 2 1 Septum formation initiator bZIP_2 PF07716.10 ERZ95938.1 - 0.0014 18.4 10.4 0.08 12.7 0.5 3.0 2 1 1 3 3 3 2 Basic region leucine zipper ATG16 PF08614.6 ERZ95938.1 - 0.002 17.9 6.4 0.0021 17.9 4.4 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) IncA PF04156.9 ERZ95938.1 - 0.0032 17.0 7.9 0.0037 16.9 5.5 1.1 1 0 0 1 1 1 1 IncA protein TMF_TATA_bd PF12325.3 ERZ95938.1 - 0.0041 16.8 5.2 0.0056 16.3 3.6 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 ERZ95938.1 - 0.0043 16.8 11.8 0.21 11.4 3.0 2.2 1 1 1 2 2 2 2 TATA element modulatory factor 1 DNA binding CCDC155 PF14662.1 ERZ95938.1 - 0.0046 16.5 6.5 0.0085 15.7 4.5 1.4 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 Halo_GVPC PF05465.8 ERZ95938.1 - 0.0054 16.6 1.6 4.3 7.3 0.1 3.1 2 1 1 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat SAB PF04382.8 ERZ95938.1 - 0.012 15.3 2.5 0.012 15.3 1.7 2.1 1 1 0 2 2 2 0 SAB domain DUF904 PF06005.7 ERZ95938.1 - 0.013 15.7 10.5 0.14 12.4 7.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Uso1_p115_C PF04871.8 ERZ95938.1 - 0.015 15.1 8.3 0.076 12.9 5.7 1.8 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF641 PF04859.7 ERZ95938.1 - 0.019 14.6 4.0 0.022 14.4 2.7 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Mod_r PF07200.8 ERZ95938.1 - 0.023 14.6 4.3 0.024 14.5 3.0 1.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Shugoshin_N PF07558.6 ERZ95938.1 - 0.027 14.1 8.2 1.7 8.3 0.3 3.1 1 1 2 3 3 3 0 Shugoshin N-terminal coiled-coil region FlxA PF14282.1 ERZ95938.1 - 0.029 14.3 1.3 0.044 13.7 0.9 1.4 1 1 0 1 1 1 0 FlxA-like protein BLOC1_2 PF10046.4 ERZ95938.1 - 0.03 14.4 3.6 0.039 14.0 2.5 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4201 PF13870.1 ERZ95938.1 - 0.031 13.7 6.1 0.044 13.2 4.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Spectrin PF00435.16 ERZ95938.1 - 0.039 14.2 4.3 0.041 14.1 3.0 1.0 1 0 0 1 1 1 0 Spectrin repeat Seryl_tRNA_N PF02403.17 ERZ95938.1 - 0.054 13.5 8.8 0.092 12.7 6.1 1.3 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMCO5 PF14992.1 ERZ95938.1 - 0.067 12.3 3.0 0.075 12.1 2.1 1.0 1 0 0 1 1 1 0 TMCO5 family Uds1 PF15456.1 ERZ95938.1 - 0.07 13.1 4.6 0.081 12.9 3.2 1.1 1 0 0 1 1 1 0 Up-regulated During Septation BicD PF09730.4 ERZ95938.1 - 0.071 11.4 5.7 0.078 11.3 4.0 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D DUF4140 PF13600.1 ERZ95938.1 - 0.084 13.3 5.4 0.14 12.5 3.7 1.4 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Toxin_39 PF15500.1 ERZ95938.1 - 0.089 12.9 3.5 0.28 11.3 0.9 2.0 1 1 1 2 2 2 0 Putative RNase-like toxin PEARLI-4 PF05278.7 ERZ95938.1 - 0.09 12.1 4.7 0.099 11.9 3.2 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) NYD-SP28_assoc PF14775.1 ERZ95938.1 - 0.11 12.1 6.7 1.2 8.9 2.2 3.1 1 1 2 3 3 3 0 Sperm tail C-terminal domain DUF972 PF06156.8 ERZ95938.1 - 0.12 12.7 5.1 0.18 12.1 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF837 PF05769.6 ERZ95938.1 - 0.12 11.8 6.4 0.1 12.0 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF837) Antigen_Bd37 PF11641.3 ERZ95938.1 - 0.13 11.5 4.0 0.14 11.4 2.8 1.1 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Phage_GP20 PF06810.6 ERZ95938.1 - 0.14 11.5 4.8 0.17 11.2 3.3 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF3450 PF11932.3 ERZ95938.1 - 0.16 11.1 2.3 0.18 11.0 1.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Erp_C PF06780.6 ERZ95938.1 - 0.17 11.7 6.4 0.39 10.5 4.4 1.6 1 1 0 1 1 1 0 Erp protein C-terminus DUF4200 PF13863.1 ERZ95938.1 - 0.18 11.7 9.7 0.46 10.4 4.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Nup54 PF13874.1 ERZ95938.1 - 0.18 11.4 2.8 4.3 7.0 0.1 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 HALZ PF02183.13 ERZ95938.1 - 0.19 11.4 11.8 0.76 9.5 0.8 3.1 1 1 2 3 3 3 0 Homeobox associated leucine zipper Spc7 PF08317.6 ERZ95938.1 - 0.25 9.9 6.9 0.3 9.6 4.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TSC22 PF01166.13 ERZ95938.1 - 0.36 10.8 9.6 3.8 7.5 1.2 2.8 1 1 1 2 2 2 0 TSC-22/dip/bun family TPR_MLP1_2 PF07926.7 ERZ95938.1 - 0.39 10.4 7.6 2.6 7.7 5.3 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3373 PF11853.3 ERZ95938.1 - 0.41 9.1 2.2 0.41 9.1 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Striatin PF08232.7 ERZ95938.1 - 0.5 10.6 8.8 0.19 12.0 1.2 2.2 1 1 1 2 2 2 0 Striatin family Viral_P18 PF04521.8 ERZ95938.1 - 0.59 9.5 3.2 1.2 8.6 2.2 1.5 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein DUF724 PF05266.9 ERZ95938.1 - 0.66 9.5 4.9 0.79 9.3 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Vps51 PF08700.6 ERZ95938.1 - 0.69 9.7 3.7 23 4.9 2.5 2.5 1 1 0 1 1 1 0 Vps51/Vps67 DUF342 PF03961.8 ERZ95938.1 - 0.7 8.2 6.9 0.71 8.2 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Nnf1 PF03980.9 ERZ95938.1 - 0.8 9.7 6.5 13 5.7 0.2 2.9 2 1 1 3 3 3 0 Nnf1 zf-C4H2 PF10146.4 ERZ95938.1 - 0.93 9.4 5.8 1.1 9.1 4.0 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein APG6 PF04111.7 ERZ95938.1 - 1.7 7.6 6.5 2 7.3 4.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 ERZ95938.1 - 2.8 6.8 5.6 3.1 6.6 3.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4398 PF14346.1 ERZ95938.1 - 3.1 7.9 8.0 2.4 8.2 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) Cep57_CLD_2 PF14197.1 ERZ95938.1 - 4.3 7.3 12.3 22 5.1 3.2 2.7 1 1 0 2 2 2 0 Centrosome localisation domain of PPC89 CCDC92 PF14916.1 ERZ95938.1 - 4.4 6.9 6.2 1.1e+02 2.5 2.9 3.0 1 1 1 2 2 2 0 Coiled-coil domain of unknown function DUF465 PF04325.8 ERZ95938.1 - 4.9 6.9 12.5 1.7 8.3 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF465) MerR-DNA-bind PF09278.6 ERZ95938.1 - 5.5 7.4 7.1 30 5.1 3.6 2.2 1 1 1 2 2 2 0 MerR, DNA binding IF4E PF01652.13 ERZ95940.1 - 6.2e-58 194.9 0.2 7.7e-58 194.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E 2-oxoacid_dh PF00198.18 ERZ95941.1 - 3e-81 272.0 0.0 4.2e-81 271.6 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.12 ERZ95941.1 - 2.5e-19 68.6 0.2 4.3e-19 67.8 0.1 1.4 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.17 ERZ95941.1 - 7.4e-17 60.7 0.4 1.4e-16 59.8 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD PF00529.15 ERZ95941.1 - 0.02 14.2 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Biotin_lipoyl_2 PF13533.1 ERZ95941.1 - 0.047 13.3 0.2 0.32 10.7 0.1 2.2 1 1 0 2 2 2 0 Biotin-lipoyl like MIR PF02815.14 ERZ95944.1 - 1.1e-12 47.9 0.3 9.3e-06 25.3 0.0 3.1 1 1 2 3 3 3 3 MIR domain Ins145_P3_rec PF08709.6 ERZ95944.1 - 1.8e-05 23.9 0.1 0.0014 17.6 0.0 2.2 2 0 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor APH PF01636.18 ERZ95945.1 - 0.00038 20.2 0.2 0.00044 20.0 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ERZ95945.1 - 0.0028 16.8 0.0 0.0032 16.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ERZ95945.1 - 0.025 13.7 0.0 0.03 13.5 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Lectin_N PF03954.9 ERZ95946.1 - 0.038 13.4 0.3 0.096 12.0 0.1 1.7 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain SecA_SW PF07516.8 ERZ95946.1 - 0.12 12.1 9.7 0.14 11.8 0.0 2.1 1 1 1 2 2 2 0 SecA Wing and Scaffold domain IncFII_repA PF02387.10 ERZ95946.1 - 0.89 8.6 9.1 1.3 8.1 6.3 1.3 1 1 0 1 1 1 0 IncFII RepA protein family RloB PF13707.1 ERZ95947.1 - 0.02 14.5 0.6 0.02 14.5 0.4 1.1 1 0 0 1 1 1 0 RloB-like protein Sporozoite_P67 PF05642.6 ERZ95948.1 - 0.00038 18.4 2.1 0.00045 18.2 1.5 1.2 1 0 0 1 1 1 1 Sporozoite P67 surface antigen EspB PF05802.6 ERZ95948.1 - 0.0015 17.5 4.2 0.0024 16.8 2.9 1.3 1 0 0 1 1 1 1 Enterobacterial EspB protein Packaging_FI PF14000.1 ERZ95948.1 - 0.025 14.7 1.1 0.044 13.9 0.8 1.3 1 0 0 1 1 1 0 DNA packaging protein FI DUF4549 PF15082.1 ERZ95948.1 - 0.026 14.1 0.4 0.042 13.5 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) SSP160 PF06933.6 ERZ95948.1 - 0.18 9.7 19.5 0.28 9.1 13.5 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Syntaxin-6_N PF09177.6 ERZ95948.1 - 0.22 11.9 4.8 2.1 8.7 2.6 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Mucin PF01456.12 ERZ95948.1 - 0.51 10.1 22.1 0.77 9.5 15.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein DivIVA PF05103.8 ERZ95948.1 - 0.68 9.9 4.8 0.35 10.9 1.6 1.7 2 0 0 2 2 2 0 DivIVA protein Paramyxo_C PF01692.13 ERZ95948.1 - 4.5 6.8 12.7 1.6 8.2 7.0 1.7 1 1 0 1 1 1 0 Paramyxovirus non-structural protein c SAM_1 PF00536.25 ERZ95949.1 - 0.0039 17.3 0.2 0.0048 17.0 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4381 PF14316.1 ERZ95950.1 - 0.027 14.5 0.2 0.03 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) RINT1_TIP1 PF04437.8 ERZ95951.1 - 1.7e-60 205.0 0.0 2.3e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family Abhydrolase_3 PF07859.8 ERZ95952.1 - 6.6e-14 51.9 0.0 6.2e-13 48.7 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ERZ95952.1 - 2.9e-10 40.0 0.0 4.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 ERZ95952.1 - 7.6e-09 34.8 0.0 2.5e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.16 ERZ95952.1 - 4.4e-06 26.0 0.0 1.9e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 ERZ95952.1 - 6.5e-06 26.1 0.0 2e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ERZ95952.1 - 0.093 12.1 0.1 1.9 7.8 0.0 2.2 1 1 0 2 2 2 0 Phospholipase/Carboxylesterase Diacid_rec PF05651.8 ERZ95952.1 - 0.11 11.9 0.4 0.33 10.3 0.1 1.9 2 0 0 2 2 2 0 Putative sugar diacid recognition RPAP2_Rtr1 PF04181.8 ERZ95953.1 - 6.6e-22 77.3 3.6 1.9e-21 75.9 2.5 1.8 1 0 0 1 1 1 1 Rtr1/RPAP2 family BTB PF00651.26 ERZ95955.1 - 9.3e-18 64.2 0.0 2.3e-17 62.9 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.21 ERZ95955.1 - 0.059 13.6 0.0 0.27 11.4 0.0 2.2 2 1 0 2 2 2 0 MATH domain Proteasom_Rpn13 PF04683.8 ERZ95956.1 - 2.2e-24 85.3 0.4 3.3e-24 84.7 0.3 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor CorA PF01544.13 ERZ95957.1 - 3.3e-47 160.9 5.2 3.9e-47 160.6 3.6 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3149 PF11346.3 ERZ95957.1 - 1.1 8.8 6.9 1.3 8.6 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) DUF836 PF05768.9 ERZ95958.1 - 0.02 15.1 0.1 0.02 15.1 0.1 2.1 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) DUF4276 PF14103.1 ERZ95958.1 - 0.054 13.3 0.9 0.058 13.2 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) zinc-ribbons_6 PF07191.7 ERZ95958.1 - 0.89 9.3 7.1 10 5.9 5.2 2.2 1 1 1 2 2 2 0 zinc-ribbons Thioredoxin_3 PF13192.1 ERZ95958.1 - 3.2 7.6 6.9 0.5 10.2 0.2 2.1 2 0 0 2 2 2 0 Thioredoxin domain RabGAP-TBC PF00566.13 ERZ95960.1 - 8.2e-51 172.5 1.5 1.1e-50 172.0 1.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain V-SNARE_C PF12352.3 ERZ95961.1 - 4.4e-15 55.4 1.6 1e-14 54.3 1.1 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus TPR_MLP1_2 PF07926.7 ERZ95961.1 - 0.0013 18.4 3.2 0.035 13.8 0.0 2.2 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein Sec20 PF03908.8 ERZ95961.1 - 0.017 14.7 4.1 0.031 13.9 0.0 2.8 3 1 0 3 3 3 0 Sec20 Dimerisation PF08100.6 ERZ95961.1 - 0.048 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Dimerisation domain DUF1664 PF07889.7 ERZ95961.1 - 0.08 12.7 0.6 6.4 6.5 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.7 ERZ95961.1 - 0.09 12.5 1.2 0.6 9.8 0.1 2.4 2 1 0 2 2 2 0 Laminin Domain II Allexi_40kDa PF05549.6 ERZ95961.1 - 0.11 11.7 4.1 0.029 13.6 0.7 1.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein P22_AR_C PF10548.4 ERZ95961.1 - 0.39 10.6 2.6 1.1 9.1 0.1 2.8 3 0 0 3 3 3 0 P22AR C-terminal domain Vma12 PF11712.3 ERZ95961.1 - 1.6 8.4 5.2 5.9 6.5 0.1 2.8 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Syntaxin PF00804.20 ERZ95961.1 - 2.1 8.5 5.7 3.1 8.0 1.5 2.5 1 1 1 2 2 2 0 Syntaxin Aminotran_1_2 PF00155.16 ERZ95962.1 - 1.6e-59 201.7 0.0 2e-59 201.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ERZ95962.1 - 1.2e-05 24.5 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 ERZ95962.1 - 0.0004 19.6 0.0 0.00061 19.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 ERZ95962.1 - 0.00075 17.8 0.0 0.0014 17.0 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 ERZ95962.1 - 0.0088 14.8 0.0 0.04 12.6 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V E2F_TDP PF02319.15 ERZ95963.1 - 1.2e-23 82.4 0.2 1.2e-23 82.4 0.1 2.0 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.5 ERZ95963.1 - 1.3e-09 37.8 0.2 3.1e-09 36.6 0.1 1.7 1 0 0 1 1 1 1 Transcription factor DP DUF641 PF04859.7 ERZ95963.1 - 0.063 13.0 1.8 0.067 12.9 0.6 1.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) AUX_IAA PF02309.11 ERZ95963.1 - 0.12 12.1 2.3 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 AUX/IAA family His_Phos_1 PF00300.17 ERZ95964.1 - 2e-10 41.0 0.0 2.7e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) COG5 PF10392.4 ERZ95965.1 - 0.052 13.4 2.1 0.085 12.8 1.1 1.6 1 1 0 1 1 1 0 Golgi transport complex subunit 5 DUF4423 PF14394.1 ERZ95965.1 - 0.074 12.5 0.3 0.093 12.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) GrpE PF01025.14 ERZ95965.1 - 0.12 11.9 0.9 0.19 11.2 0.6 1.4 1 0 0 1 1 1 0 GrpE MRG PF05712.8 ERZ95965.1 - 0.13 11.0 1.7 0.24 10.2 1.2 1.5 1 1 0 1 1 1 0 MRG MitMem_reg PF13012.1 ERZ95965.1 - 0.3 11.1 4.0 0.33 11.0 1.8 1.6 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function DivIVA PF05103.8 ERZ95965.1 - 0.59 10.1 5.3 0.26 11.3 1.0 2.1 2 1 0 2 2 2 0 DivIVA protein DUF2205 PF10224.4 ERZ95965.1 - 0.71 9.4 6.9 2.4 7.7 1.9 2.4 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) p450 PF00067.17 ERZ95967.1 - 0.002 16.7 0.0 0.002 16.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CobN-Mg_chel PF02514.11 ERZ95970.1 - 0.05 11.0 0.7 0.064 10.6 0.5 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase CBM49 PF09478.5 ERZ95970.1 - 0.057 13.5 0.5 0.12 12.4 0.4 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 DUF3533 PF12051.3 ERZ95970.1 - 0.14 10.8 1.0 0.16 10.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) FHIPEP PF00771.15 ERZ95970.1 - 1 7.6 3.8 1.2 7.3 2.6 1.1 1 0 0 1 1 1 0 FHIPEP family T4_deiodinase PF00837.12 ERZ95973.1 - 6.1e-27 94.1 0.0 7.6e-27 93.8 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF2847 PF11009.3 ERZ95973.1 - 0.079 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) Epiglycanin_TR PF05647.6 ERZ95976.1 - 3.6 7.4 8.1 11 5.9 5.6 1.8 1 1 0 1 1 1 0 Tandem-repeating region of mucin, epiglycanin-like ubiquitin PF00240.18 ERZ95977.1 - 4.3e-45 150.9 11.0 3.4e-15 55.2 0.2 4.1 4 0 0 4 4 4 3 Ubiquitin family T4_deiodinase PF00837.12 ERZ95977.1 - 2.4e-28 98.7 0.0 3.8e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Iodothyronine deiodinase Rad60-SLD PF11976.3 ERZ95977.1 - 1.1e-24 85.9 6.9 1e-08 34.7 0.2 3.7 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like ZZ PF00569.12 ERZ95977.1 - 5.5e-10 38.6 6.3 1.2e-09 37.5 4.4 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type TUG-UBL1 PF11470.3 ERZ95977.1 - 1.8e-06 27.7 0.3 0.7 9.8 0.0 3.7 3 0 0 3 3 3 3 GLUT4 regulating protein TUG Ubiquitin_2 PF14560.1 ERZ95977.1 - 9.6e-05 22.5 5.2 0.018 15.2 0.1 3.8 3 1 0 3 3 3 1 Ubiquitin-like domain YukD PF08817.5 ERZ95977.1 - 0.00023 21.6 0.0 2.2 8.9 0.0 3.4 3 0 0 3 3 3 2 WXG100 protein secretion system (Wss), protein YukD DUF2407 PF10302.4 ERZ95977.1 - 0.0021 18.1 0.1 1.6 8.9 0.0 2.9 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Redoxin PF08534.5 ERZ95977.1 - 0.018 14.5 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Redoxin C1_3 PF07649.7 ERZ95977.1 - 0.34 10.9 8.2 0.72 9.9 5.7 1.6 1 0 0 1 1 1 0 C1-like domain COPI_assoc PF08507.5 ERZ95978.1 - 1.6 8.4 13.2 2.3 7.8 9.1 1.2 1 0 0 1 1 1 0 COPI associated protein Sigma_reg_N PF13800.1 ERZ95978.1 - 2.7 8.0 4.7 21 5.2 1.8 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal MARVEL PF01284.18 ERZ95978.1 - 4.2 7.1 16.8 2.1 8.1 5.6 2.0 1 1 1 2 2 2 0 Membrane-associating domain Pkinase_Tyr PF07714.12 ERZ95979.1 - 5.6e-38 130.4 0.0 6.4e-38 130.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95979.1 - 1.1e-33 116.5 0.0 1.3e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ95979.1 - 8.8e-05 22.3 0.0 0.00013 21.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ95979.1 - 0.0009 18.5 0.2 0.0029 16.8 0.1 1.8 1 1 1 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ERZ95979.1 - 0.0014 18.0 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family AAA-ATPase_like PF09820.4 ERZ95980.1 - 2.8e-28 98.8 1.8 6.8e-23 81.2 0.1 2.3 1 1 1 2 2 2 2 Predicted AAA-ATPase zf-RING_5 PF14634.1 ERZ95981.1 - 0.038 13.7 1.3 0.038 13.7 0.9 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-TFIIB PF13453.1 ERZ95981.1 - 0.051 12.7 4.4 1.4 8.1 0.1 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger SNF2_N PF00176.18 ERZ95983.1 - 1.6e-35 122.3 3.1 1.8e-35 122.2 2.1 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain FA_desaturase PF00487.19 ERZ95984.1 - 2e-42 145.4 8.8 3.1e-42 144.7 6.1 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF2512 PF10710.4 ERZ95984.1 - 0.72 9.2 6.0 0.49 9.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2512) IF-2B PF01008.12 ERZ95985.1 - 4.4e-74 248.9 1.0 5.3e-74 248.7 0.7 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family IFN-gamma PF00714.12 ERZ95985.1 - 0.06 13.1 0.5 0.12 12.1 0.4 1.5 1 0 0 1 1 1 0 Interferon gamma tRNA-synt_2d PF01409.15 ERZ95986.1 - 1.1e-93 312.9 0.0 1.6e-93 312.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ERZ95986.1 - 1e-07 31.7 0.1 2.2e-07 30.6 0.1 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 ERZ95986.1 - 4.5e-07 28.9 0.1 0.00031 19.6 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class II (D, K and N) Pkinase_Tyr PF07714.12 ERZ95987.1 - 9.3e-38 129.7 0.0 1.2e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ95987.1 - 2.4e-37 128.5 0.0 4.7e-37 127.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ95987.1 - 0.0024 17.6 0.1 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Prok-RING_1 PF14446.1 ERZ95987.1 - 0.28 10.9 3.7 0.24 11.1 0.8 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 HAD_2 PF13419.1 ERZ95988.1 - 2.4e-26 93.0 0.0 2.9e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ERZ95988.1 - 1.5e-11 45.0 0.0 1.6e-09 38.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ERZ95988.1 - 2.1e-06 27.3 0.0 3.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 ERZ95988.1 - 0.0038 17.0 0.1 0.2 11.5 0.0 2.5 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD PF12710.2 ERZ95988.1 - 0.017 15.2 0.0 0.033 14.3 0.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 ERZ95988.1 - 0.081 12.5 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 Acid Phosphatase DUF89 PF01937.14 ERZ95989.1 - 7.2e-109 363.8 1.2 8.2e-109 363.6 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DDE_Tnp_Tn3 PF01526.12 ERZ95991.1 - 0.33 9.4 4.0 3.4 6.1 0.1 2.0 1 1 1 2 2 2 0 Tn3 transposase DDE domain ERK-JNK_inhib PF15002.1 ERZ95991.1 - 0.34 10.2 2.3 0.37 10.1 1.6 1.3 1 1 0 1 1 1 0 ERK and JNK pathways, inhibitor Sulfatase PF00884.18 ERZ95991.1 - 0.43 9.7 7.9 1 8.4 1.2 2.0 1 1 1 2 2 2 0 Sulfatase FAA_hydrolase_N PF09298.6 ERZ95992.1 - 0.096 12.6 0.5 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal CENP-B_dimeris PF09026.5 ERZ95992.1 - 8 6.7 11.9 10 6.4 7.4 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SNF2_N PF00176.18 ERZ95993.1 - 6.8e-32 110.4 0.1 7.4e-32 110.3 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD_2 PF06733.10 ERZ95993.1 - 0.004 16.5 0.1 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.10 ERZ95993.1 - 0.0075 16.1 0.1 0.0095 15.7 0.1 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3688 PF12461.3 ERZ95994.1 - 1.9 8.9 7.0 7.9 6.9 4.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3688) tRNA-synt_1e PF01406.14 ERZ95996.1 - 6.8e-131 435.8 0.5 1.7e-130 434.5 0.3 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 ERZ95996.1 - 1.9e-10 39.9 0.6 5e-07 28.7 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ERZ95996.1 - 0.00025 19.2 0.0 0.00066 17.8 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.6 ERZ95996.1 - 0.00047 20.3 0.0 0.00047 20.3 0.0 2.1 2 0 0 2 2 2 1 DALR domain tRNA-synt_1c PF00749.16 ERZ95996.1 - 0.02 13.5 0.0 0.02 13.5 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain Dna2 PF08696.6 ERZ95996.1 - 0.046 13.0 0.0 0.13 11.5 0.0 1.7 1 0 0 1 1 1 0 DNA replication factor Dna2 CH PF00307.26 ERZ95996.1 - 0.47 10.5 3.3 1.2 9.2 0.2 2.8 3 0 0 3 3 3 0 Calponin homology (CH) domain ATP-synt_B PF00430.13 ERZ95996.1 - 9.6 6.0 17.8 5.6 6.7 10.3 2.1 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) LUC7 PF03194.10 ERZ95997.1 - 3.5e-76 256.0 11.9 4.3e-76 255.8 8.2 1.0 1 0 0 1 1 1 1 LUC7 N_terminus APG6 PF04111.7 ERZ95997.1 - 0.0024 16.9 5.8 0.0038 16.3 4.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 DUF4200 PF13863.1 ERZ95997.1 - 0.0076 16.1 7.5 0.0076 16.1 5.2 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4200) Laminin_I PF06008.9 ERZ95997.1 - 0.0096 15.2 4.2 0.017 14.4 1.9 1.9 2 0 0 2 2 2 1 Laminin Domain I FemAB PF02388.11 ERZ95997.1 - 0.013 14.1 1.3 0.072 11.7 0.5 2.0 2 0 0 2 2 2 0 FemAB family NPV_P10 PF05531.7 ERZ95997.1 - 0.015 15.4 0.9 0.029 14.5 0.7 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF2730 PF10805.3 ERZ95997.1 - 0.043 13.5 0.2 0.097 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) DUF3573 PF12097.3 ERZ95997.1 - 0.061 11.9 0.5 0.077 11.6 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DALR_1 PF05746.10 ERZ95997.1 - 0.066 13.1 1.3 0.13 12.2 0.9 1.5 1 0 0 1 1 1 0 DALR anticodon binding domain ALS_ss_C PF10369.4 ERZ95997.1 - 0.089 12.5 1.0 0.17 11.5 0.7 1.4 1 0 0 1 1 1 0 Small subunit of acetolactate synthase bZIP_1 PF00170.16 ERZ95997.1 - 0.12 12.3 0.4 0.12 12.3 0.3 2.7 3 0 0 3 3 3 0 bZIP transcription factor eIF3_N PF09440.5 ERZ95997.1 - 0.21 11.7 4.0 0.25 11.5 2.1 1.5 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain Syntaxin_2 PF14523.1 ERZ95997.1 - 0.5 10.4 6.4 0.26 11.3 1.4 2.6 3 0 0 3 3 3 0 Syntaxin-like protein Shugoshin_N PF07558.6 ERZ95997.1 - 0.66 9.7 5.1 0.19 11.4 0.9 2.2 2 1 0 2 2 1 0 Shugoshin N-terminal coiled-coil region Med4 PF10018.4 ERZ95997.1 - 1.2 8.4 6.8 0.39 10.0 2.4 2.0 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DivIC PF04977.10 ERZ95997.1 - 5.1 6.6 9.1 0.15 11.5 0.6 2.7 3 1 0 3 3 3 0 Septum formation initiator FBD PF08387.5 ERZ95998.1 - 0.024 14.0 1.2 3 7.3 0.1 3.6 2 1 0 2 2 2 0 FBD FBD PF08387.5 ERZ95999.1 - 1.3 8.5 9.6 0.59 9.6 0.2 4.3 4 1 1 5 5 5 0 FBD RTC4 PF14474.1 ERZ96000.1 - 5.4e-15 55.4 0.1 6.7e-15 55.1 0.1 1.1 1 0 0 1 1 1 1 RTC4-like domain UPF0158 PF03682.8 ERZ96000.1 - 0.093 12.3 0.2 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0158) Prefoldin_2 PF01920.15 ERZ96002.1 - 2.4e-19 69.0 9.0 3e-19 68.7 6.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1993 PF09351.5 ERZ96002.1 - 0.00053 19.9 1.4 0.00064 19.6 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) TroA PF01297.12 ERZ96002.1 - 0.056 12.6 1.2 0.079 12.1 0.6 1.4 1 1 0 1 1 1 0 Periplasmic solute binding protein family Peptidase_S46 PF10459.4 ERZ96002.1 - 0.11 10.8 4.7 0.12 10.7 3.2 1.0 1 0 0 1 1 1 0 Peptidase S46 YPEB PF14620.1 ERZ96002.1 - 0.41 9.6 4.8 1 8.3 3.3 1.6 1 1 0 1 1 1 0 YpeB sporulation DUF4618 PF15397.1 ERZ96002.1 - 0.94 8.7 10.7 3.5 6.8 7.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) FKBP_N PF01346.13 ERZ96002.1 - 3.4 7.7 7.6 5.6 7.0 0.8 2.2 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DASH_Dad2 PF08654.5 ERZ96003.1 - 0.001 19.0 0.7 0.0013 18.7 0.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad2 Laminin_N PF00055.12 ERZ96003.1 - 0.0083 15.1 0.1 0.0096 14.9 0.1 1.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) RRM_1 PF00076.17 ERZ96004.1 - 2.4e-19 68.7 0.7 1.6e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ96004.1 - 5.9e-15 55.0 0.3 2.6e-06 27.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ96004.1 - 2.2e-11 43.4 2.1 0.00015 21.4 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ERZ96004.1 - 5.6e-09 35.7 0.4 0.0015 18.3 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.1 ERZ96004.1 - 9.4e-07 28.5 0.1 0.033 13.9 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Gemini_AC4_5_2 PF08464.5 ERZ96004.1 - 0.00016 21.2 0.1 0.67 9.7 0.0 2.2 2 0 0 2 2 2 2 Geminivirus AC4/5 conserved region Bac_DNA_binding PF00216.16 ERZ96004.1 - 0.00067 19.6 0.5 0.5 10.4 0.1 2.4 2 0 0 2 2 2 2 Bacterial DNA-binding protein SBP_bac_3 PF00497.15 ERZ96004.1 - 0.00082 18.6 0.5 0.002 17.4 0.3 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 UPF0004 PF00919.15 ERZ96004.1 - 0.0037 17.0 0.3 2.4 8.0 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0004 MULE PF10551.4 ERZ96004.1 - 0.004 17.2 0.1 1 9.5 0.0 2.4 2 0 0 2 2 2 1 MULE transposase domain DUF4496 PF14908.1 ERZ96004.1 - 0.051 13.4 0.0 0.65 9.8 0.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4496) 2HCT PF03390.10 ERZ96004.1 - 0.058 11.7 0.0 2.4 6.4 0.0 2.0 2 0 0 2 2 2 0 2-hydroxycarboxylate transporter family AARP2CN PF08142.7 ERZ96004.1 - 0.07 12.6 1.4 13 5.4 0.0 3.6 3 1 1 4 4 4 0 AARP2CN (NUC121) domain Jag_N PF14804.1 ERZ96004.1 - 0.21 11.6 1.9 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Jag N-terminus NOC3p PF07540.6 ERZ96005.1 - 4.5e-33 113.3 3.2 4.5e-33 113.3 2.2 3.6 3 1 1 4 4 4 1 Nucleolar complex-associated protein CBF PF03914.12 ERZ96005.1 - 4e-30 104.4 0.0 4e-30 104.4 0.0 2.5 3 0 0 3 3 3 1 CBF/Mak21 family UBX PF00789.15 ERZ96005.1 - 0.0037 17.2 0.0 0.016 15.2 0.0 2.1 1 0 0 1 1 1 1 UBX domain LTP_2 PF14368.1 ERZ96005.1 - 0.31 11.1 2.6 8.2 6.6 0.1 2.4 1 1 1 2 2 2 0 Probable lipid transfer DUF393 PF04134.7 ERZ96006.1 - 3.3e-18 66.8 0.0 4.2e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF393 DAO PF01266.19 ERZ96007.1 - 2.8e-49 167.9 0.0 3.2e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ERZ96007.1 - 1.1e-07 31.7 0.1 2.4e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 ERZ96007.1 - 1.5e-05 25.2 0.1 0.00058 20.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 ERZ96007.1 - 7.9e-05 22.6 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain GMC_oxred_N PF00732.14 ERZ96007.1 - 0.00012 21.3 0.0 0.00047 19.4 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ERZ96007.1 - 0.00056 18.9 0.0 0.0034 16.3 0.0 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 ERZ96007.1 - 0.00072 18.5 0.0 0.0089 14.9 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 ERZ96007.1 - 0.00086 19.2 0.1 0.0024 17.8 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ERZ96007.1 - 0.0013 18.8 0.0 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ERZ96007.1 - 0.0015 17.0 0.0 0.011 14.2 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.14 ERZ96007.1 - 0.0018 17.4 0.1 0.0028 16.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 ERZ96007.1 - 0.0043 16.8 0.1 0.0081 15.9 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_oxidored PF12831.2 ERZ96007.1 - 0.043 12.8 0.0 0.077 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ApbA PF02558.11 ERZ96007.1 - 0.14 11.5 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.20 ERZ96007.1 - 0.24 11.3 0.1 0.53 10.1 0.1 1.5 1 0 0 1 1 1 0 short chain dehydrogenase SAP30_Sin3_bdg PF13867.1 ERZ96008.1 - 3.2e-18 65.3 0.5 5.9e-18 64.4 0.4 1.4 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Period_C PF12114.3 ERZ96008.1 - 3.9 7.0 10.8 5.3 6.6 7.5 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region HMG_box PF00505.14 ERZ96009.1 - 4.5e-07 30.0 2.3 4.5e-07 30.0 1.6 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ96009.1 - 0.00013 22.2 2.0 0.00013 22.2 1.4 2.2 1 1 1 2 2 2 1 HMG-box domain Ada3 PF10198.4 ERZ96009.1 - 0.12 12.1 1.7 0.21 11.3 1.2 1.3 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 tRNA-synt_2 PF00152.15 ERZ96010.1 - 4.2e-87 292.0 0.5 6.3e-87 291.4 0.4 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ERZ96010.1 - 1.2e-11 44.2 0.1 2.4e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ERZ96010.1 - 1.3e-06 27.8 0.1 0.0076 15.4 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ERZ96010.1 - 0.0011 18.5 0.1 0.0044 16.6 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) ECH PF00378.15 ERZ96011.1 - 1.5e-22 79.9 0.0 1.7e-22 79.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family AhpC-TSA PF00578.16 ERZ96012.1 - 4.4e-28 97.4 0.0 5.3e-28 97.1 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ERZ96012.1 - 1.2e-13 50.8 0.0 1.4e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 ERZ96012.1 - 0.027 14.3 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme DUF2360 PF10152.4 ERZ96013.1 - 1.1 9.4 3.7 1.2 9.4 2.5 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Pkinase PF00069.20 ERZ96014.1 - 2.2e-35 122.0 0.0 3.7e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96014.1 - 6.9e-35 120.3 0.0 8.7e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase 7TM_GPCR_Srbc PF10316.4 ERZ96016.1 - 0.075 12.2 0.1 0.08 12.1 0.0 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc DDE_1 PF03184.14 ERZ96017.1 - 1.7e-19 69.8 0.1 3.5e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF750 PF04721.12 ERZ96017.1 - 0.043 13.8 0.8 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF750) Fer4_12 PF13353.1 ERZ96018.1 - 0.1 12.7 3.9 0.081 13.0 1.2 2.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain HTH_Tnp_Tc5 PF03221.11 ERZ96019.1 - 2.5e-14 52.8 0.1 3.3e-14 52.4 0.1 1.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ96019.1 - 0.0033 16.5 0.5 0.014 14.5 0.0 2.0 2 1 0 2 2 2 1 DDE superfamily endonuclease DUF4373 PF14297.1 ERZ96019.1 - 0.075 13.3 0.0 0.092 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4373) BAG PF02179.11 ERZ96019.1 - 0.075 13.1 0.1 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 BAG domain HMG_box PF00505.14 ERZ96020.1 - 1.2e-08 35.0 0.0 2.6e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ96020.1 - 0.0015 18.8 0.7 0.0029 17.9 0.0 1.8 2 0 0 2 2 2 1 HMG-box domain DUF4613 PF15390.1 ERZ96020.1 - 0.0077 14.4 2.6 0.0097 14.1 1.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4613) RNase_H PF00075.19 ERZ96022.1 - 0.00046 20.5 0.3 0.001 19.4 0.0 1.7 2 0 0 2 2 2 1 RNase H Imm14 PF15428.1 ERZ96023.1 - 0.35 11.2 2.4 4.1 7.8 0.2 2.2 1 1 1 2 2 2 0 Immunity protein 14 DUF1836 PF08876.6 ERZ96024.1 - 0.024 14.3 0.2 0.99 9.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1836) DUF2777 PF10949.3 ERZ96024.1 - 0.058 13.0 0.1 0.066 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) FlaC_arch PF05377.6 ERZ96024.1 - 0.067 13.1 0.1 0.32 10.9 0.0 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Stm1_N PF09598.5 ERZ96027.1 - 0.027 15.1 0.9 0.039 14.6 0.6 1.3 1 0 0 1 1 1 0 Stm1 Tombus_movement PF05318.7 ERZ96027.1 - 0.083 13.5 0.4 0.11 13.0 0.3 1.2 1 0 0 1 1 1 0 Tombusvirus movement protein PseudoU_synth_2 PF00849.17 ERZ96030.1 - 1.9e-22 79.8 0.1 4.1e-22 78.7 0.1 1.5 2 0 0 2 2 2 1 RNA pseudouridylate synthase Nuc_sug_transp PF04142.10 ERZ96031.1 - 1.6e-41 142.0 15.8 1.6e-41 142.0 11.0 1.5 2 0 0 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.11 ERZ96031.1 - 3e-06 26.9 11.5 3e-06 26.9 8.0 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ERZ96031.1 - 0.00016 21.7 9.3 0.00016 21.7 6.4 3.9 4 0 0 4 4 4 2 EamA-like transporter family Matrix PF00661.16 ERZ96031.1 - 0.011 14.0 0.2 0.017 13.4 0.2 1.2 1 0 0 1 1 1 0 Viral matrix protein UAA PF08449.6 ERZ96031.1 - 0.075 11.9 23.0 0.32 9.8 7.3 4.1 1 1 2 3 3 3 0 UAA transporter family Mito_carr PF00153.22 ERZ96032.1 - 7.4e-70 230.7 0.3 5.6e-24 83.6 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 ERZ96032.1 - 2e-17 63.0 3.9 3.3e-05 23.9 0.2 4.6 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ERZ96032.1 - 3.2e-17 60.4 3.3 0.00013 20.9 0.0 5.9 7 0 0 7 7 7 3 EF hand EF-hand_6 PF13405.1 ERZ96032.1 - 6.2e-15 53.6 2.0 0.00094 18.8 0.0 6.1 7 0 0 7 7 7 3 EF-hand domain EF-hand_8 PF13833.1 ERZ96032.1 - 9.4e-12 44.3 0.4 0.003 17.1 0.0 5.1 4 1 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 ERZ96032.1 - 1.5e-06 27.2 0.4 0.23 10.8 0.1 3.8 3 0 0 3 3 3 3 EF hand DUF77 PF01910.12 ERZ96034.1 - 6.5e-27 93.0 0.0 7.8e-27 92.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF77 Ykof PF07615.6 ERZ96034.1 - 0.0088 16.1 0.1 0.016 15.3 0.0 1.4 2 0 0 2 2 2 1 YKOF-related Family Elicitin PF00964.12 ERZ96034.1 - 0.096 12.6 0.2 0.13 12.1 0.2 1.4 1 1 0 1 1 1 0 Elicitin DUF3098 PF11297.3 ERZ96035.1 - 0.041 13.5 3.2 0.4 10.4 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) DUF106 PF01956.11 ERZ96036.1 - 0.064 12.7 0.1 0.077 12.5 0.1 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 7tm_1 PF00001.16 ERZ96036.1 - 0.082 12.0 0.2 0.093 11.8 0.1 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) HisKA PF00512.20 ERZ96037.1 - 0.085 12.8 0.0 0.14 12.1 0.0 1.4 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain NIR_SIR PF01077.17 ERZ96039.1 - 1.6e-57 193.2 0.0 5.2e-47 159.1 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.20 ERZ96039.1 - 6.8e-32 110.4 0.0 1.4e-31 109.4 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NIR_SIR_ferr PF03460.12 ERZ96039.1 - 3.6e-26 90.5 0.0 1.7e-13 50.0 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain POR_N PF01855.14 ERZ96039.1 - 3.9e-09 36.3 0.0 1.4e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Pox_Ag35 PF03286.9 ERZ96039.1 - 0.02 14.4 2.5 0.04 13.4 1.7 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CPSase_L_D2 PF02786.12 ERZ96040.1 - 2.1e-110 367.0 0.0 6.8e-85 283.6 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 ERZ96040.1 - 8.6e-44 148.2 0.7 2.1e-43 147.0 0.5 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 ERZ96040.1 - 1.9e-39 135.2 0.2 5.5e-22 78.3 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 ERZ96040.1 - 2.2e-38 130.7 0.0 3.4e-18 65.7 0.0 2.7 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 ERZ96040.1 - 1.5e-22 79.7 0.0 1.7e-10 40.1 0.0 3.9 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 ERZ96040.1 - 4.2e-20 71.8 0.0 3.3e-09 36.3 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ERZ96040.1 - 2.9e-15 56.2 0.2 1.2e-06 28.0 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 ERZ96040.1 - 2.5e-11 43.4 0.0 1.2e-06 28.1 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 ERZ96040.1 - 2.9e-06 27.2 0.1 0.048 13.5 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_5 PF13549.1 ERZ96040.1 - 3.7e-05 23.0 0.4 0.21 10.7 0.0 2.8 3 0 0 3 3 3 2 ATP-grasp domain MGS PF02142.17 ERZ96040.1 - 0.0002 21.2 0.1 0.0013 18.5 0.0 2.5 2 0 0 2 2 2 1 MGS-like domain HTH_23 PF13384.1 ERZ96040.1 - 0.00079 18.9 0.0 0.0031 17.1 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain GARS_A PF01071.14 ERZ96040.1 - 0.00085 18.9 0.1 0.23 11.0 0.0 2.5 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Peptidase_M17_N PF02789.12 ERZ96040.1 - 0.013 15.2 0.5 0.074 12.8 0.0 2.5 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain ATP-grasp_2 PF08442.5 ERZ96040.1 - 0.033 13.5 0.0 9 5.6 0.0 2.6 2 0 0 2 2 2 0 ATP-grasp domain adh_short PF00106.20 ERZ96041.1 - 6e-06 26.2 0.0 7.2e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ96041.1 - 0.019 14.6 0.0 0.022 14.4 0.0 1.1 1 0 0 1 1 1 0 KR domain Nramp PF01566.13 ERZ96042.1 - 9.5e-56 189.1 18.2 4.8e-31 107.8 6.3 4.0 2 2 2 4 4 4 4 Natural resistance-associated macrophage protein MFS_1 PF07690.11 ERZ96043.1 - 1.1e-49 169.0 53.4 3.5e-49 167.3 35.4 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 ERZ96043.1 - 1.1e-16 60.2 27.0 1.7e-16 59.5 18.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 ERZ96043.1 - 7.2e-10 38.0 17.3 7.2e-10 38.0 12.0 3.3 1 1 2 3 3 3 1 Sugar (and other) transporter Late_protein_L2 PF00513.13 ERZ96043.1 - 0.074 11.8 1.9 0.11 11.3 1.3 1.1 1 0 0 1 1 1 0 Late Protein L2 F-box-like PF12937.2 ERZ96044.1 - 0.027 14.1 0.5 0.15 11.7 0.6 2.1 2 0 0 2 2 2 0 F-box-like Rrn6 PF10214.4 ERZ96045.1 - 0.00072 17.7 1.3 0.00072 17.7 0.9 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Nucleo_P87 PF07267.6 ERZ96045.1 - 0.0076 15.0 1.3 0.0075 15.0 0.9 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus capsid protein P87 Pkinase_Tyr PF07714.12 ERZ96046.1 - 7.2e-35 120.3 0.0 8.3e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96046.1 - 2e-31 109.0 0.3 2.3e-31 108.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ96046.1 - 0.00037 19.6 0.1 0.00044 19.3 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ96046.1 - 0.013 15.2 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ96046.1 - 0.014 14.7 0.4 0.017 14.4 0.3 1.1 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ96046.1 - 0.017 14.4 0.4 0.038 13.3 0.3 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL WaaY PF06176.6 ERZ96046.1 - 0.064 12.4 0.1 0.078 12.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) KH_1 PF00013.24 ERZ96047.1 - 1.5e-06 27.7 0.1 1.5e-06 27.7 0.0 2.2 2 1 0 2 2 2 1 KH domain KH_3 PF13014.1 ERZ96047.1 - 0.00026 20.5 0.2 0.00026 20.5 0.1 2.0 2 0 0 2 2 2 1 KH domain Baculo_LEF-2 PF03041.9 ERZ96047.1 - 0.12 12.0 2.1 0.15 11.7 1.4 1.3 1 0 0 1 1 1 0 lef-2 KH_4 PF13083.1 ERZ96047.1 - 0.14 11.8 0.2 0.14 11.8 0.1 2.9 3 1 0 3 3 3 0 KH domain Pkinase_Tyr PF07714.12 ERZ96051.1 - 2.7e-05 23.3 0.0 0.00013 21.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96051.1 - 3.4e-05 23.1 0.3 0.00026 20.2 0.2 2.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ96051.1 - 0.0055 16.4 0.0 0.0097 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family AAA PF00004.24 ERZ96052.1 - 2.5e-19 69.7 0.0 8e-19 68.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ERZ96052.1 - 3.6e-08 34.2 0.4 2.3e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ERZ96052.1 - 0.00014 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ERZ96052.1 - 0.00029 20.5 0.0 0.00061 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ERZ96052.1 - 0.00074 19.8 2.8 0.002 18.4 0.1 2.8 2 2 0 2 2 2 1 AAA domain Zot PF05707.7 ERZ96052.1 - 0.00092 18.7 0.2 0.024 14.1 0.1 2.4 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_22 PF13401.1 ERZ96052.1 - 0.00095 19.3 0.2 0.0074 16.4 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ96052.1 - 0.0061 16.4 0.2 0.045 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.9 ERZ96052.1 - 0.0071 16.2 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ERZ96052.1 - 0.013 14.6 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 ERZ96052.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.1 ERZ96052.1 - 0.017 14.8 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 ERZ96052.1 - 0.026 13.9 0.0 0.053 12.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 ERZ96052.1 - 0.1 12.7 0.0 0.39 10.9 0.0 2.1 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 ERZ96052.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.16 ERZ96052.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 ERZ96052.1 - 0.17 11.3 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sel1 PF08238.7 ERZ96053.1 - 7.1e-116 376.1 62.3 3.7e-12 46.4 0.4 12.4 12 0 0 12 12 12 11 Sel1 repeat TPR_6 PF13174.1 ERZ96053.1 - 4.2e-09 36.2 23.1 0.26 11.8 0.0 8.5 8 1 0 8 8 8 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ERZ96053.1 - 0.00012 22.0 0.1 6.2 6.9 0.0 5.8 4 2 4 8 8 8 1 Influenza Matrix protein (M1) C-terminal domain TPR_16 PF13432.1 ERZ96053.1 - 0.0003 21.3 7.5 0.32 11.7 0.0 6.1 7 2 0 7 7 7 1 Tetratricopeptide repeat zf-BED PF02892.10 ERZ96053.1 - 0.00034 20.3 4.8 0.00082 19.0 3.4 1.7 1 0 0 1 1 1 1 BED zinc finger DUF4227 PF14004.1 ERZ96053.1 - 0.49 10.2 3.1 18 5.2 0.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) MIT PF04212.13 ERZ96053.1 - 6.3 6.7 44.4 2.5 8.0 0.0 10.4 9 2 1 10 10 10 0 MIT (microtubule interacting and transport) domain DUF3140 PF11338.3 ERZ96054.1 - 0.058 13.5 0.0 0.065 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) Nucleoplasmin PF03066.10 ERZ96055.1 - 0.0065 15.9 2.0 0.0094 15.4 1.4 1.3 1 0 0 1 1 1 1 Nucleoplasmin DUF4611 PF15387.1 ERZ96055.1 - 0.024 14.7 2.9 0.038 14.1 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RXT2_N PF08595.6 ERZ96055.1 - 0.11 12.3 1.7 0.17 11.7 1.2 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.7 ERZ96055.1 - 0.16 11.1 4.3 0.18 11.0 3.0 1.1 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.6 ERZ96055.1 - 0.17 9.6 2.2 0.21 9.4 1.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Sigma70_ner PF04546.8 ERZ96055.1 - 0.18 11.4 2.3 0.26 10.8 1.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF605 PF04652.11 ERZ96055.1 - 0.23 10.8 13.7 0.27 10.5 9.5 1.0 1 0 0 1 1 1 0 Vta1 like DUF3245 PF11595.3 ERZ96055.1 - 0.62 10.3 6.0 1.3 9.2 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) COX1 PF00115.15 ERZ96059.1 - 5.2e-22 78.0 7.7 1.7e-13 50.0 0.2 2.1 1 1 1 2 2 2 2 Cytochrome C and Quinol oxidase polypeptide I DUF4386 PF14329.1 ERZ96059.1 - 0.056 12.9 1.1 0.089 12.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) Pkinase PF00069.20 ERZ96061.1 - 4.6e-37 127.5 0.2 5.8e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96061.1 - 7e-34 117.0 0.0 8.2e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ96061.1 - 0.0001 21.6 1.0 0.00017 20.9 0.7 1.4 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ96061.1 - 0.0014 17.7 0.3 0.0019 17.2 0.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ96061.1 - 0.0018 18.0 0.1 0.0028 17.4 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ERZ96061.1 - 0.0038 16.5 0.1 0.0052 16.1 0.1 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL DUF4361 PF14274.1 ERZ96061.1 - 0.015 14.9 0.3 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4361) Kinase-like PF14531.1 ERZ96061.1 - 0.028 13.3 0.0 0.041 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Hemocyanin_M PF00372.14 ERZ96062.1 - 2.6e-36 125.3 0.0 3.7e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 Hemocyanin, copper containing domain Hemocyanin_C PF03723.9 ERZ96062.1 - 1.2e-34 119.5 0.0 2.4e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Hemocyanin, ig-like domain Tyrosinase PF00264.15 ERZ96062.1 - 8e-10 39.2 0.0 8e-10 39.2 0.0 2.0 2 1 0 2 2 2 1 Common central domain of tyrosinase Mnd1 PF03962.10 ERZ96062.1 - 0.063 12.9 0.6 0.1 12.2 0.4 1.3 1 0 0 1 1 1 0 Mnd1 family Arg_tRNA_synt_N PF03485.11 ERZ96062.1 - 0.13 12.8 1.1 0.3 11.6 0.7 1.6 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain BTB PF00651.26 ERZ96066.1 - 3.6e-18 65.5 0.2 6.8e-18 64.6 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96066.1 - 0.00042 20.1 0.1 0.0046 16.7 0.0 2.7 1 1 2 3 3 3 1 BTB And C-terminal Kelch Peptidase_C24 PF03510.9 ERZ96066.1 - 0.072 13.2 0.2 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 2C endopeptidase (C24) cysteine protease family BTB PF00651.26 ERZ96067.1 - 3.4e-12 46.3 0.1 7.9e-12 45.1 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96067.1 - 6.8e-10 39.0 0.7 6.8e-10 39.0 0.5 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ96067.1 - 1.9e-05 24.4 0.1 0.00012 21.9 0.1 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ96068.1 - 1.4e-11 44.4 0.4 2.4e-11 43.7 0.3 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ96068.1 - 0.036 13.9 1.7 0.32 10.8 1.2 2.6 1 1 0 1 1 1 0 BTB And C-terminal Kelch GerPC PF10737.4 ERZ96069.1 - 0.014 15.1 0.2 0.042 13.6 0.0 1.7 1 1 0 1 1 1 0 Spore germination protein GerPC RNase_H PF00075.19 ERZ96070.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 RNase H ubiquitin PF00240.18 ERZ96071.1 - 4.8e-14 51.5 0.0 8.5e-14 50.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96071.1 - 2.5e-09 36.6 0.0 4.6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ERZ96071.1 - 0.0022 17.4 0.0 0.0034 16.8 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ERZ96071.1 - 0.0049 16.2 0.8 0.0096 15.3 0.2 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3990) Carb_anhydrase PF00194.16 ERZ96072.1 - 4.6e-22 78.2 0.2 1.3e-21 76.7 0.1 1.6 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase F-box-like PF12937.2 ERZ96073.1 - 9.4e-06 25.2 0.2 2.7e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like Pkinase_Tyr PF07714.12 ERZ96074.1 - 0.003 16.6 0.0 0.0041 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase XG_FTase PF03254.8 ERZ96075.1 - 3.4e-06 25.8 0.0 4.5e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Xyloglucan fucosyltransferase NOPS PF08075.6 ERZ96075.1 - 0.044 14.1 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 NOPS (NUC059) domain BNIP2 PF12496.3 ERZ96075.1 - 2.4 8.3 10.7 3.6 7.7 7.3 1.6 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 ANTH PF07651.11 ERZ96076.1 - 0.07 11.8 0.1 0.082 11.6 0.1 1.2 1 0 0 1 1 1 0 ANTH domain PRESAN PF09687.5 ERZ96076.1 - 0.12 12.4 6.1 0.34 10.9 2.1 2.1 2 0 0 2 2 2 0 Plasmodium RESA N-terminal ATP-synt_ab_N PF02874.18 ERZ96077.1 - 0.062 13.5 0.0 0.083 13.1 0.0 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, beta-barrel domain PCI PF01399.22 ERZ96078.1 - 8.4e-15 54.9 0.1 1.4e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 PCI domain DUF3014 PF11219.3 ERZ96078.1 - 0.02 14.7 0.7 0.047 13.5 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3014) TAP42 PF04177.7 ERZ96079.1 - 5.9e-91 304.9 16.4 6.6e-91 304.7 11.4 1.0 1 0 0 1 1 1 1 TAP42-like family DUF2962 PF11176.3 ERZ96079.1 - 0.006 16.1 8.4 0.016 14.7 5.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) WD40 PF00400.27 ERZ96080.1 - 9.8e-57 186.9 3.6 1.1e-11 44.1 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ERZ96080.1 - 2.2e-29 102.5 0.0 8.1e-29 100.6 0.0 1.9 2 1 1 3 3 3 1 Coatomer WD associated region BBS2_Mid PF14783.1 ERZ96080.1 - 2.7e-05 23.8 0.1 0.091 12.5 0.0 3.8 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 ERZ96080.1 - 0.0024 16.0 3.9 3.1 5.8 0.1 3.8 4 1 0 4 4 4 3 Nucleoporin Nup120/160 TPR_18 PF13512.1 ERZ96082.1 - 0.0024 17.8 0.0 0.0027 17.7 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat Alpha_adaptinC2 PF02883.15 ERZ96082.1 - 0.0068 16.7 0.0 0.0074 16.5 0.0 1.1 1 0 0 1 1 1 1 Adaptin C-terminal domain HSF_DNA-bind PF00447.12 ERZ96084.1 - 1.4e-33 115.1 0.6 1.4e-33 115.1 0.4 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding Cortex-I_coil PF09304.5 ERZ96084.1 - 0.004 17.1 1.5 0.0062 16.5 1.1 1.2 1 0 0 1 1 1 1 Cortexillin I, coiled coil Toxin_52 PF15605.1 ERZ96084.1 - 0.012 15.4 0.4 0.043 13.6 0.2 1.8 2 0 0 2 2 2 0 Putative toxin 52 APG6 PF04111.7 ERZ96084.1 - 0.013 14.5 0.9 0.018 14.1 0.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Cor1 PF04803.7 ERZ96084.1 - 0.023 14.4 5.6 0.034 13.9 3.6 1.4 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region HAP1_N PF04849.8 ERZ96084.1 - 0.042 12.8 3.6 0.056 12.3 2.5 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ALMS_motif PF15309.1 ERZ96084.1 - 0.051 13.4 0.7 0.067 13.0 0.5 1.3 1 0 0 1 1 1 0 ALMS motif ADIP PF11559.3 ERZ96084.1 - 0.067 13.0 3.1 0.099 12.5 2.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Snapin_Pallidin PF14712.1 ERZ96084.1 - 0.068 13.4 1.5 0.12 12.7 1.0 1.4 1 0 0 1 1 1 0 Snapin/Pallidin DUF3407 PF11887.3 ERZ96084.1 - 0.08 12.2 0.1 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3407) DASH_Hsk3 PF08227.6 ERZ96084.1 - 0.087 13.0 4.6 0.36 11.0 0.1 3.2 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like DUF1311 PF07007.7 ERZ96084.1 - 0.2 11.7 2.0 0.29 11.2 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1311) SseC PF04888.7 ERZ96084.1 - 2.7 7.2 6.6 6.8 5.9 4.5 1.6 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Serglycin PF04360.7 ERZ96085.1 - 0.001 18.7 0.1 0.0017 18.0 0.1 1.4 1 0 0 1 1 1 1 Serglycin DUF4636 PF15468.1 ERZ96085.1 - 0.0047 16.4 0.1 0.0088 15.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) DBD_Tnp_Mut PF03108.10 ERZ96085.1 - 0.18 11.4 0.9 13 5.4 0.0 2.5 2 0 0 2 2 2 0 MuDR family transposase DUF373 PF04123.8 ERZ96085.1 - 1.9 7.4 6.8 0.48 9.3 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Pkinase PF00069.20 ERZ96087.1 - 8.9e-46 156.1 0.0 7.5e-44 149.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96087.1 - 8.8e-35 120.0 0.0 1.1e-34 119.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ96087.1 - 1.9e-06 27.0 0.0 3.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ96087.1 - 4.9e-05 23.1 0.1 8.6e-05 22.3 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ERZ96087.1 - 0.00055 19.3 0.0 0.0013 18.0 0.0 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ96087.1 - 0.00071 18.6 0.1 0.0037 16.3 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RE_R_Pab1 PF09522.5 ERZ96087.1 - 0.081 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 R.Pab1 restriction endonuclease JmjN PF02375.12 ERZ96088.1 - 0.0086 15.5 0.3 0.015 14.7 0.2 1.3 1 0 0 1 1 1 1 jmjN domain MitMem_reg PF13012.1 ERZ96089.1 - 0.01 15.9 1.5 0.031 14.3 1.3 1.6 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function ArfGap PF01412.13 ERZ96090.1 - 5.6e-37 126.1 1.2 6.6e-37 125.8 0.9 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4570 PF15134.1 ERZ96090.1 - 0.055 13.3 0.0 0.17 11.7 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4570) Cytochrome_CBB3 PF13442.1 ERZ96090.1 - 0.16 12.1 0.5 0.73 10.0 0.3 2.0 1 1 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III Piwi PF02171.12 ERZ96091.1 - 9.3e-104 346.6 0.0 1.1e-103 346.3 0.0 1.1 1 0 0 1 1 1 1 Piwi domain Pkinase_Tyr PF07714.12 ERZ96093.1 - 8.5e-08 31.5 0.0 1.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase TMF_DNA_bd PF12329.3 ERZ96094.1 - 0.0074 16.0 3.9 0.0074 16.0 2.7 3.9 3 0 0 3 3 3 1 TATA element modulatory factor 1 DNA binding AreA_N PF07573.6 ERZ96094.1 - 0.66 10.5 6.3 0.13 12.7 0.9 2.2 2 0 0 2 2 2 0 Nitrogen regulatory protein AreA N terminus DUF641 PF04859.7 ERZ96095.1 - 0.013 15.2 0.3 0.013 15.2 0.2 2.1 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF745 PF05335.8 ERZ96095.1 - 0.04 13.4 0.1 0.14 11.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF745) TMF_DNA_bd PF12329.3 ERZ96095.1 - 1.2 8.9 16.0 0.1 12.3 0.4 4.1 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding Cullin_Nedd8 PF10557.4 ERZ96095.1 - 6.2 6.7 10.5 1 9.2 0.8 3.6 4 1 0 4 4 4 0 Cullin protein neddylation domain DUF4446 PF14584.1 ERZ96095.1 - 8.9 6.1 13.1 3 7.6 0.5 3.8 2 2 1 3 3 3 0 Protein of unknown function (DUF4446) Pkinase PF00069.20 ERZ96096.1 - 8.2e-10 38.2 0.0 8.7e-10 38.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96096.1 - 1.6e-08 33.9 0.0 1.7e-08 33.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4539 PF15072.1 ERZ96098.1 - 0.0018 17.9 0.1 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) Aldo_ket_red PF00248.16 ERZ96099.1 - 2e-05 23.5 0.0 2.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family SNARE PF05739.14 ERZ96099.1 - 0.0082 15.8 0.6 0.017 14.7 0.2 1.7 1 1 1 2 2 2 1 SNARE domain Aldo_ket_red PF00248.16 ERZ96100.1 - 3.5e-29 101.5 0.0 8.4e-29 100.2 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family Cys_Met_Meta_PP PF01053.15 ERZ96100.1 - 0.071 11.3 0.0 0.17 10.1 0.0 1.6 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme SNARE PF05739.14 ERZ96100.1 - 0.21 11.3 1.3 0.3 10.7 0.1 1.9 2 0 0 2 2 2 0 SNARE domain BTB PF00651.26 ERZ96101.1 - 4.4e-14 52.4 0.4 9.3e-14 51.3 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ERZ96102.1 - 1.2e-18 67.0 0.1 2.3e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96102.1 - 8.9e-16 58.1 1.3 8.9e-16 58.1 0.9 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ96102.1 - 6.7e-10 38.7 0.8 8.3e-07 28.8 0.4 2.6 1 1 1 2 2 2 2 BTB And C-terminal Kelch DUF2207 PF09972.4 ERZ96102.1 - 0.26 9.8 8.0 0.56 8.7 2.5 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BTB PF00651.26 ERZ96103.1 - 2.3e-19 69.3 0.1 5.6e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96103.1 - 3.1e-15 56.3 1.0 3.1e-15 56.3 0.7 2.5 3 0 0 3 3 3 1 TLD BACK PF07707.10 ERZ96103.1 - 2.2e-08 33.8 2.5 2.1e-07 30.6 1.7 2.4 1 1 0 1 1 1 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ96104.1 - 4e-19 68.9 1.3 4e-19 68.9 0.9 2.4 3 0 0 3 3 3 1 TLD BTB PF00651.26 ERZ96104.1 - 1.5e-16 60.3 0.0 3.2e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96104.1 - 7.8e-10 38.5 1.5 1.5e-07 31.1 0.4 2.7 2 0 0 2 2 2 2 BTB And C-terminal Kelch TNV_CP PF03898.8 ERZ96104.1 - 0.12 11.4 0.0 14 4.6 0.0 2.3 2 0 0 2 2 2 0 Satellite tobacco necrosis virus coat protein DUF2315 PF10231.4 ERZ96105.1 - 0.016 15.0 0.4 0.02 14.7 0.3 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) SAP PF02037.22 ERZ96108.1 - 3.1e-10 39.2 0.8 8e-10 37.9 0.5 1.6 1 0 0 1 1 1 1 SAP domain Rho_N PF07498.7 ERZ96108.1 - 0.011 15.5 0.8 0.043 13.5 0.1 2.3 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain DUF1892 PF08987.5 ERZ96108.1 - 0.021 14.8 1.1 0.098 12.6 0.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1892) Cwf_Cwc_15 PF04889.7 ERZ96108.1 - 0.24 11.0 19.1 35 3.9 13.3 2.1 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PAT1 PF09770.4 ERZ96108.1 - 6.2 4.9 32.5 8.7 4.4 22.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Myb_DNA-binding PF00249.26 ERZ96109.1 - 2.2e-08 34.0 0.0 4.1e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ96109.1 - 8.8e-06 25.7 0.2 2.5e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain SAE2 PF08573.5 ERZ96109.1 - 0.06 14.0 4.7 0.053 14.2 2.3 1.6 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF605 PF04652.11 ERZ96109.1 - 0.065 12.6 13.9 0.068 12.5 9.7 1.0 1 0 0 1 1 1 0 Vta1 like Lin-8 PF03353.10 ERZ96109.1 - 0.089 12.0 9.0 0.12 11.6 6.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Merozoite_SPAM PF07133.6 ERZ96109.1 - 0.39 10.5 11.3 0.59 10.0 7.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.9 ERZ96109.1 - 0.42 8.5 6.9 0.41 8.6 4.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF566 PF04484.7 ERZ96109.1 - 1.8 7.9 12.3 2.4 7.5 8.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF2413 PF10310.4 ERZ96109.1 - 2.9 6.6 12.4 3.2 6.4 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Myb_DNA-bind_5 PF13873.1 ERZ96109.1 - 3.9 7.4 7.0 1.6 8.6 0.2 2.9 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain CMV_1a PF12467.3 ERZ96109.1 - 5.4 7.3 11.7 7.7 6.8 8.1 1.2 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family MIP-T3 PF10243.4 ERZ96109.1 - 9.3 4.5 23.3 12 4.1 16.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Asp23 PF03780.8 ERZ96110.1 - 0.0056 16.9 0.6 0.017 15.3 0.0 2.1 2 1 1 3 3 3 1 Asp23 family Endonuc-FokI_C PF09254.6 ERZ96110.1 - 0.0084 15.2 2.0 0.0084 15.2 1.4 1.7 1 1 1 2 2 2 1 Restriction endonuclease FokI, C terminal Toxin_43 PF15604.1 ERZ96110.1 - 0.62 10.0 9.5 0.87 9.6 6.5 1.3 1 1 0 1 1 1 0 Putative toxin 43 TPX2_importin PF12214.3 ERZ96112.1 - 5.5e-08 33.0 9.0 1.8e-06 28.1 0.6 2.5 2 1 0 2 2 2 2 Cell cycle regulated microtubule associated protein DUF4224 PF13986.1 ERZ96112.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) Cys_Met_Meta_PP PF01053.15 ERZ96113.1 - 2.7e-142 473.6 0.0 3.1e-142 473.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ERZ96113.1 - 3.2e-10 39.6 0.0 6.1e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 ERZ96113.1 - 4.3e-07 29.2 0.1 6.7e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 ERZ96113.1 - 1.9e-06 26.9 0.4 5.4e-06 25.3 0.1 1.9 2 1 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ERZ96113.1 - 0.00034 19.8 0.1 0.0011 18.2 0.1 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.6 ERZ96113.1 - 0.0018 16.6 0.1 0.0027 16.0 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Radical_SAM PF04055.16 ERZ96113.1 - 0.015 15.4 0.0 4.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Radical SAM superfamily CSTF_C PF14304.1 ERZ96115.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal F-box-like PF12937.2 ERZ96116.1 - 3.9e-05 23.2 0.9 9.1e-05 22.1 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ERZ96118.1 - 0.00013 21.6 1.8 0.00025 20.6 1.2 1.6 1 1 0 1 1 1 1 F-box-like F-box-like PF12937.2 ERZ96120.1 - 0.00019 21.1 1.9 0.00024 20.7 0.4 1.9 2 0 0 2 2 2 1 F-box-like DUF2999 PF11212.3 ERZ96120.1 - 0.013 15.5 0.5 3.7 7.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2999) LEM PF03020.10 ERZ96123.1 - 0.003 16.9 0.0 4.4 6.8 0.0 3.2 3 0 0 3 3 3 2 LEM domain SAM_1 PF00536.25 ERZ96123.1 - 0.039 14.1 0.0 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Stn1_C PF12659.2 ERZ96124.1 - 0.027 14.3 3.1 0.17 11.6 2.2 2.1 1 1 0 1 1 1 0 Telomere capping C-terminal wHTH W2 PF02020.13 ERZ96126.1 - 1.2e-10 41.1 0.2 5.5e-10 39.0 0.0 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.19 ERZ96126.1 - 1.8e-10 39.8 14.9 0.00093 18.5 2.2 3.9 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 ERZ96126.1 - 3.6e-08 33.0 0.0 7e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 ERZ96126.1 - 0.00082 19.4 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 ERZ96126.1 - 0.0046 16.4 0.7 0.0046 16.4 0.5 3.7 1 1 2 3 3 3 2 Hexapeptide repeat of succinyl-transferase Cwf_Cwc_15 PF04889.7 ERZ96126.1 - 0.59 9.8 7.9 0.94 9.1 5.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Actin PF00022.14 ERZ96127.1 - 1.9e-61 207.6 0.0 2.2e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ERZ96127.1 - 2.1e-14 52.8 0.0 6.1e-14 51.3 0.0 1.6 1 1 0 1 1 1 1 MreB/Mbl protein CENP-S PF15630.1 ERZ96128.1 - 6.5e-28 96.7 0.2 9e-28 96.2 0.1 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 ERZ96128.1 - 0.00052 19.6 0.1 0.0012 18.5 0.1 1.6 1 1 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 ERZ96128.1 - 0.017 14.8 0.1 0.022 14.5 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Lsr2 PF11774.3 ERZ96128.1 - 0.083 12.8 0.2 0.13 12.1 0.1 1.4 1 1 0 1 1 1 0 Lsr2 CaMBD PF02888.11 ERZ96128.1 - 0.17 11.7 1.1 0.25 11.1 0.4 1.6 2 0 0 2 2 2 0 Calmodulin binding domain Abhydrolase_3 PF07859.8 ERZ96129.1 - 5.8e-33 114.2 0.0 6.1e-24 84.7 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ERZ96129.1 - 9.5e-06 24.4 0.1 5.7e-05 21.9 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) ThiF PF00899.16 ERZ96130.1 - 1.3e-40 138.4 0.1 3.1e-40 137.1 0.0 1.7 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 ERZ96130.1 - 1.6e-29 101.2 2.6 7.7e-29 99.0 0.7 2.7 3 0 0 3 3 3 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ERZ96130.1 - 6e-22 76.7 1.9 1.2e-21 75.7 1.3 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 ERZ96130.1 - 1.1e-08 35.0 0.6 3.2e-08 33.5 0.4 1.8 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.15 ERZ96130.1 - 1e-05 25.6 0.2 4.8e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 ERZ96130.1 - 0.0032 17.6 0.1 0.012 15.8 0.0 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding ERF PF04404.7 ERZ96130.1 - 0.029 13.8 0.0 0.08 12.4 0.0 1.7 1 0 0 1 1 1 0 ERF superfamily zf-H2C2_2 PF13465.1 ERZ96131.1 - 1.7e-14 53.3 25.6 2e-10 40.4 2.0 3.7 4 1 0 4 4 3 2 Zinc-finger double domain zf-C2H2 PF00096.21 ERZ96131.1 - 9e-14 50.8 26.5 6.9e-05 22.9 0.6 3.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ96131.1 - 2.9e-09 36.6 26.4 0.0016 18.6 1.1 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ERZ96131.1 - 1.3e-05 24.9 11.1 0.0043 16.9 0.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 ERZ96131.1 - 0.00017 21.1 0.9 0.00017 21.1 0.6 2.9 4 0 0 4 4 3 1 zinc-finger of a C2HC-type C1_4 PF07975.7 ERZ96131.1 - 0.00094 19.1 12.1 0.008 16.1 3.8 2.3 1 1 1 2 2 2 2 TFIIH C1-like domain RRN7 PF11781.3 ERZ96131.1 - 0.00098 18.5 3.0 0.5 9.9 0.0 3.0 3 0 0 3 3 3 2 RNA polymerase I-specific transcription initiation factor Rrn7 GAGA PF09237.6 ERZ96131.1 - 0.0034 16.9 2.0 0.0034 16.9 1.4 2.3 1 1 1 2 2 2 1 GAGA factor zf-met PF12874.2 ERZ96131.1 - 0.0046 17.1 15.7 0.7 10.1 1.3 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.5 ERZ96131.1 - 0.0066 16.3 9.5 0.71 9.8 3.7 3.0 1 1 1 2 2 2 1 Zinc ribbon domain DUF164 PF02591.10 ERZ96131.1 - 0.012 15.4 3.0 0.21 11.4 0.1 2.4 2 1 0 2 2 2 0 Putative zinc ribbon domain SprT-like PF10263.4 ERZ96131.1 - 0.016 14.8 6.3 0.044 13.4 4.4 1.7 1 1 0 1 1 1 0 SprT-like family zf-CHY PF05495.7 ERZ96131.1 - 0.018 15.1 9.8 0.033 14.3 6.8 1.4 1 1 0 1 1 1 0 CHY zinc finger zf-H2C2_5 PF13909.1 ERZ96131.1 - 0.077 13.2 4.8 0.077 13.2 3.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 ERZ96131.1 - 0.095 12.8 17.5 2.2 8.5 1.4 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc-ribbons_6 PF07191.7 ERZ96131.1 - 0.1 12.3 6.4 28 4.5 4.5 2.9 1 1 0 1 1 1 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.2 ERZ96131.1 - 0.1 12.3 10.8 0.18 11.6 4.6 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_5 PF13719.1 ERZ96131.1 - 0.16 11.5 10.8 2.2 7.9 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ERZ96131.1 - 0.18 11.5 11.0 2.6 7.7 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-DNL PF05180.7 ERZ96131.1 - 0.22 11.2 6.7 0.062 13.0 0.7 2.1 2 0 0 2 2 2 0 DNL zinc finger zf-C4 PF00105.13 ERZ96131.1 - 0.32 11.2 7.2 1.2 9.3 2.7 2.6 1 1 2 3 3 3 0 Zinc finger, C4 type (two domains) HypA PF01155.14 ERZ96131.1 - 0.36 10.5 5.4 1.2 8.8 3.7 1.8 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF2256 PF10013.4 ERZ96131.1 - 0.43 10.3 6.6 2.5 7.9 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-AN1 PF01428.11 ERZ96131.1 - 0.49 10.3 18.8 1.9 8.4 0.2 3.1 1 1 2 3 3 3 0 AN1-like Zinc finger DZR PF12773.2 ERZ96131.1 - 0.53 10.1 7.2 10 6.0 5.0 2.3 1 1 0 1 1 1 0 Double zinc ribbon LIM PF00412.17 ERZ96131.1 - 0.72 9.9 10.1 9.7 6.3 7.1 2.2 1 1 0 1 1 1 0 LIM domain Baculo_IE-1 PF05290.6 ERZ96131.1 - 0.76 9.5 3.6 7.8 6.2 0.3 2.6 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-met2 PF12907.2 ERZ96131.1 - 0.88 9.5 12.2 11 6.1 0.9 3.3 3 0 0 3 3 3 0 Zinc-binding zf-FCS PF06467.9 ERZ96131.1 - 0.91 9.2 6.6 4.5 7.0 0.2 2.9 1 1 2 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_2 PF12756.2 ERZ96131.1 - 1.3 9.1 13.7 11 6.1 0.2 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-RING_3 PF14369.1 ERZ96131.1 - 1.4 8.9 6.3 4.1 7.4 2.1 2.6 1 1 1 2 2 2 0 zinc-finger PHD PF00628.24 ERZ96131.1 - 1.5 8.5 9.9 23 4.7 6.9 2.5 1 1 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.1 ERZ96131.1 - 1.6 8.5 11.5 7.7 6.3 7.9 2.1 1 1 0 1 1 1 0 zinc-RING finger domain IBR PF01485.16 ERZ96131.1 - 1.7 8.5 10.8 10 6.0 0.4 2.8 1 1 1 2 2 2 0 IBR domain DUF3795 PF12675.2 ERZ96131.1 - 1.8 8.8 5.3 7.2 6.8 3.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) Mut7-C PF01927.11 ERZ96131.1 - 2.8 7.8 7.3 4.8 7.1 1.3 2.2 1 1 1 2 2 2 0 Mut7-C RNAse domain zf-ISL3 PF14690.1 ERZ96131.1 - 4.9 7.2 9.7 3 7.9 0.2 2.8 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Elf1 PF05129.8 ERZ96131.1 - 5.3 6.8 9.5 23 4.7 4.5 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-RING_4 PF14570.1 ERZ96131.1 - 8 6.1 7.5 8.9 5.9 3.8 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-FPG_IleRS PF06827.9 ERZ96131.1 - 8.1 6.1 8.6 9.6 5.9 0.1 2.6 3 0 0 3 3 2 0 Zinc finger found in FPG and IleRS Rubredoxin PF00301.15 ERZ96131.1 - 9 6.2 7.1 4.2 7.3 2.2 2.2 2 1 0 2 2 1 0 Rubredoxin DNA_pol_E_B PF04042.11 ERZ96132.1 - 6.7e-36 123.5 0.7 1.1e-35 122.8 0.5 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B BRO1 PF03097.13 ERZ96140.1 - 2.5e-118 395.1 0.3 2.5e-118 395.1 0.2 2.4 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 ERZ96140.1 - 4.1e-46 157.2 22.2 4.1e-46 157.2 15.4 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV CENP-Q PF13094.1 ERZ96140.1 - 0.22 11.5 0.0 0.22 11.5 0.0 3.1 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Pkinase PF00069.20 ERZ96141.1 - 6.1e-07 28.8 0.6 1e-06 28.1 0.4 1.3 1 0 0 1 1 1 1 Protein kinase domain T4_Gp59_C PF08994.5 ERZ96141.1 - 0.002 18.2 0.3 0.0042 17.2 0.2 1.5 1 0 0 1 1 1 1 T4 gene Gp59 loader of gp41 DNA helicase C-term APH PF01636.18 ERZ96141.1 - 0.0041 16.8 0.0 0.0061 16.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ERZ96143.1 - 4.1e-08 32.7 0.0 4.2e-08 32.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96143.1 - 1.3e-06 27.6 0.0 1.4e-06 27.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DNA_pol3_delta PF06144.8 ERZ96144.1 - 0.0031 17.0 2.0 0.0067 15.9 1.4 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF1664 PF07889.7 ERZ96144.1 - 0.016 15.0 3.9 0.034 13.9 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Carn_acyltransf PF00755.15 ERZ96145.1 - 1.2e-89 301.0 0.0 1.3e-89 300.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Lon_C PF05362.8 ERZ96146.1 - 1.1e-75 253.5 0.4 2.6e-75 252.2 0.3 1.7 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 ERZ96146.1 - 8.3e-29 100.7 1.5 8.3e-29 100.7 1.0 2.3 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain AAA PF00004.24 ERZ96146.1 - 3.2e-22 79.1 0.0 8.1e-22 77.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ96146.1 - 7.1e-09 35.5 0.0 3.9e-08 33.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 ERZ96146.1 - 2e-08 33.7 0.0 7.1e-08 31.9 0.0 2.0 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.6 ERZ96146.1 - 1.1e-05 24.2 0.0 2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.1 ERZ96146.1 - 1.5e-05 25.0 0.0 0.0001 22.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 ERZ96146.1 - 6.7e-05 23.7 0.3 0.00085 20.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ERZ96146.1 - 8.8e-05 21.6 0.0 0.0023 17.0 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ERZ96146.1 - 0.00011 22.1 0.0 0.00034 20.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_3 PF07726.6 ERZ96146.1 - 0.00056 19.5 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ERZ96146.1 - 0.0018 18.1 0.0 0.0046 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain Birna_VP4 PF01768.11 ERZ96146.1 - 0.0028 16.7 0.2 0.006 15.6 0.1 1.4 1 0 0 1 1 1 1 Birnavirus VP4 protein DUF258 PF03193.11 ERZ96146.1 - 0.008 15.3 0.0 0.015 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 RNA_helicase PF00910.17 ERZ96146.1 - 0.013 15.6 0.1 0.17 12.0 0.0 2.6 3 0 0 3 3 2 0 RNA helicase AAA_22 PF13401.1 ERZ96146.1 - 0.013 15.6 0.1 0.097 12.8 0.0 2.5 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ERZ96146.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.1 ERZ96146.1 - 0.022 14.3 0.4 0.042 13.4 0.3 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ERZ96146.1 - 0.03 14.6 0.9 0.078 13.2 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.1 ERZ96146.1 - 0.042 13.6 0.1 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain DUF3217 PF11506.3 ERZ96146.1 - 0.074 12.7 0.2 2.9 7.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3217) AAA_25 PF13481.1 ERZ96146.1 - 0.086 12.2 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ERZ96146.1 - 0.096 12.3 0.0 0.35 10.4 0.0 2.0 1 0 0 1 1 1 0 NACHT domain UPF0079 PF02367.12 ERZ96146.1 - 0.1 12.2 0.1 0.26 10.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 SKI PF01202.17 ERZ96146.1 - 0.23 11.3 3.6 0.18 11.6 0.1 2.2 2 0 0 2 2 2 0 Shikimate kinase ABC_tran PF00005.22 ERZ96146.1 - 1.2 9.3 4.0 1.7 8.9 0.1 2.7 2 1 0 2 2 2 0 ABC transporter CoA_transf_3 PF02515.12 ERZ96147.1 - 9.6e-37 126.0 0.0 1.3e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III DUF221 PF02714.10 ERZ96148.1 - 3.6e-105 351.3 22.6 6.5e-105 350.5 15.7 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ERZ96148.1 - 5.1e-31 107.3 0.1 5.1e-31 107.3 0.1 2.9 2 1 1 3 3 3 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ERZ96148.1 - 1.1e-10 41.8 2.2 2.8e-10 40.5 1.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) UQ_con PF00179.21 ERZ96149.1 - 0.00019 20.8 0.0 0.00021 20.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme HMG_box PF00505.14 ERZ96150.1 - 0.0002 21.5 0.2 0.00055 20.1 0.2 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box Sial-lect-inser PF09264.5 ERZ96151.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Vibrio cholerae sialidase, lectin insertion MIR PF02815.14 ERZ96151.1 - 0.1 12.0 0.0 0.6 9.6 0.0 2.2 1 1 0 1 1 1 0 MIR domain MreB_Mbl PF06723.8 ERZ96155.1 - 0.045 12.3 0.1 5.2 5.5 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein HTH_18 PF12833.2 ERZ96155.1 - 0.14 12.2 0.0 0.78 9.8 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain 60KD_IMP PF02096.15 ERZ96157.1 - 0.53 9.9 3.0 1.1 8.8 2.1 1.5 1 0 0 1 1 1 0 60Kd inner membrane protein MreB_Mbl PF06723.8 ERZ96158.1 - 1.4e-05 23.9 0.0 0.041 12.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ96158.1 - 0.00052 18.0 0.0 0.016 13.1 0.0 2.7 2 1 0 2 2 2 1 Hsp70 protein StbA PF06406.6 ERZ96158.1 - 0.15 10.9 0.0 3.9 6.3 0.0 2.1 2 0 0 2 2 2 0 StbA protein MIP-T3 PF10243.4 ERZ96160.1 - 0.012 14.1 24.8 0.014 13.8 17.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF1777 PF08648.7 ERZ96160.1 - 1.3 8.7 48.3 4.4 7.0 33.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1777) PRP38_assoc PF12871.2 ERZ96160.1 - 1.7 9.2 48.4 0.3 11.6 21.9 2.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Peptidase_U57 PF05582.7 ERZ96160.1 - 3.4 6.5 9.5 2.2 7.1 5.2 1.6 1 1 1 2 2 2 0 YabG peptidase U57 Aida_N PF08910.5 ERZ96161.1 - 0.32 11.2 3.1 0.23 11.7 0.5 1.8 2 0 0 2 2 2 0 Aida N-terminus DUF4578 PF15147.1 ERZ96161.1 - 0.94 9.8 11.6 0.2 12.0 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4578) Exonuc_VII_L PF02601.10 ERZ96161.1 - 1.2 8.2 6.9 0.2 10.8 1.8 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF3949 PF13133.1 ERZ96162.1 - 0.085 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3949) Phosphoesterase PF04185.9 ERZ96163.1 - 0.033 13.4 0.5 0.22 10.7 0.0 1.9 2 0 0 2 2 2 0 Phosphoesterase family Pkinase_Tyr PF07714.12 ERZ96166.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF972 PF06156.8 ERZ96166.1 - 0.95 9.8 3.7 1.4 9.3 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Hormone_recep PF00104.25 ERZ96168.1 - 0.0017 17.4 0.2 0.0024 17.0 0.1 1.4 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor C1_3 PF07649.7 ERZ96168.1 - 0.048 13.6 0.5 0.097 12.7 0.4 1.5 1 0 0 1 1 1 0 C1-like domain ETC_C1_NDUFA5 PF04716.9 ERZ96169.1 - 0.0029 17.0 0.0 0.0056 16.1 0.0 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Sp38 PF07354.7 ERZ96169.1 - 0.041 12.5 0.1 0.043 12.4 0.1 1.1 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) TPX2 PF06886.6 ERZ96170.1 - 1.1e-06 28.6 10.4 1.1e-06 28.6 7.2 4.5 5 0 0 5 5 5 1 Targeting protein for Xklp2 (TPX2) Phage_integrase PF00589.17 ERZ96172.1 - 5.4e-10 39.2 0.1 1.9e-08 34.1 0.0 2.2 1 1 0 1 1 1 1 Phage integrase family DUF3504 PF12012.3 ERZ96172.1 - 3.7e-07 30.0 0.2 2.8e-06 27.1 0.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF3504) CBM_20 PF00686.14 ERZ96173.1 - 5e-05 22.8 0.0 0.00012 21.6 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain DDE_3 PF13358.1 ERZ96175.1 - 2.2e-10 40.4 0.0 2.7e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 ERZ96175.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Transposase DUF2216 PF10226.4 ERZ96176.1 - 0.066 12.7 5.1 0.11 12.0 3.5 1.5 1 1 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) Borrelia_P83 PF05262.6 ERZ96176.1 - 0.33 9.1 9.4 0.32 9.2 6.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Tom37_C PF11801.3 ERZ96176.1 - 0.42 10.4 6.0 0.48 10.2 4.2 1.1 1 0 0 1 1 1 0 Tom37 C-terminal domain TPR_MLP1_2 PF07926.7 ERZ96176.1 - 0.93 9.2 12.2 1.2 8.9 7.5 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Phage_Gp23 PF10669.4 ERZ96176.1 - 1.8 8.6 9.8 2.1 8.4 6.8 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) TMPIT PF07851.8 ERZ96176.1 - 3.8 6.5 7.1 4.5 6.2 4.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1515 PF07439.6 ERZ96176.1 - 4 7.2 8.7 3.9 7.3 5.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) RRF PF01765.14 ERZ96176.1 - 5.5 6.4 12.9 4.6 6.6 8.0 1.5 1 1 1 2 2 2 0 Ribosome recycling factor APG6 PF04111.7 ERZ96176.1 - 5.5 5.9 10.7 6.2 5.7 7.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Snurportin1 PF11538.3 ERZ96176.1 - 7.3 6.4 8.9 2 8.2 3.3 2.2 1 1 2 3 3 3 0 Snurportin1 Pkinase_Tyr PF07714.12 ERZ96177.1 - 0.0001 21.5 0.0 0.00014 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96177.1 - 0.0037 16.4 0.0 0.0058 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF4224 PF13986.1 ERZ96177.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) MFS_1 PF07690.11 ERZ96178.1 - 4.5e-27 94.6 9.6 5.4e-27 94.4 6.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2207 PF09972.4 ERZ96178.1 - 1.3 7.5 8.1 0.56 8.7 0.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) HATPase_c_3 PF13589.1 ERZ96180.1 - 0.0006 19.4 0.4 0.17 11.5 0.0 3.2 2 2 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YcbB PF08664.5 ERZ96180.1 - 0.00094 18.9 3.5 0.15 11.7 0.4 3.1 2 0 0 2 2 2 2 YcbB domain DUF3514 PF12027.3 ERZ96181.1 - 0.027 13.7 3.6 0.068 12.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3514) BEN PF10523.4 ERZ96181.1 - 0.15 12.1 1.3 0.43 10.6 0.1 2.4 2 1 0 2 2 2 0 BEN domain Macro_2 PF14519.1 ERZ96184.1 - 1.3e-13 50.7 0.1 7.1e-13 48.3 0.1 1.9 1 1 0 1 1 1 1 Macro-like domain Macro PF01661.16 ERZ96184.1 - 1.7e-05 24.6 0.0 4e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Macro domain TBCC PF07986.7 ERZ96185.1 - 1.2e-32 111.8 4.0 2.8e-32 110.6 2.7 1.6 1 0 0 1 1 1 1 Tubulin binding cofactor C CTP_synth_N PF06418.9 ERZ96185.1 - 0.0015 17.6 0.1 0.0046 16.0 0.0 1.8 2 0 0 2 2 2 1 CTP synthase N-terminus SF-assemblin PF06705.6 ERZ96185.1 - 0.1 11.7 7.9 0.38 9.8 5.5 1.8 1 1 0 1 1 1 0 SF-assemblin/beta giardin DUF1900 PF08954.6 ERZ96186.1 - 8.7e-56 187.2 0.0 2.3e-55 185.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 ERZ96186.1 - 1.1e-31 108.2 0.4 2.4e-31 107.1 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 ERZ96186.1 - 9.3e-23 79.2 2.9 1.7e-06 27.7 0.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat PolyA_pol PF01743.15 ERZ96186.1 - 0.038 14.1 0.5 0.086 13.0 0.3 1.5 1 0 0 1 1 1 0 Poly A polymerase head domain Bap31 PF05529.7 ERZ96186.1 - 1.7 8.0 4.9 2.6 7.4 3.4 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like zf-DHHC PF01529.15 ERZ96187.1 - 2.2 7.6 4.2 3 7.2 2.9 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase Abhydrolase_6 PF12697.2 ERZ96188.1 - 4.5e-08 33.2 0.0 4.6e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ96188.1 - 0.00015 21.3 0.0 0.00016 21.2 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 ERZ96188.1 - 0.001 18.7 0.0 0.0011 18.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_5 PF12695.2 ERZ96188.1 - 0.0038 16.9 0.0 0.004 16.9 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ERZ96188.1 - 0.028 13.6 0.0 0.031 13.5 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) HMG-CoA_red PF00368.13 ERZ96189.1 - 3e-69 233.4 3.3 5e-69 232.7 2.3 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase SapB_1 PF05184.10 ERZ96189.1 - 0.014 15.1 3.4 2.3 8.1 0.2 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 GatB_Yqey PF02637.13 ERZ96189.1 - 0.074 12.7 1.9 0.19 11.4 0.2 2.3 2 0 0 2 2 2 0 GatB domain Abhydrolase_5 PF12695.2 ERZ96190.1 - 5.4e-11 42.4 0.0 8.5e-11 41.7 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ERZ96190.1 - 3.6e-08 33.5 0.0 6e-08 32.8 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ERZ96190.1 - 2.7e-05 23.4 0.0 8.8e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF1749 PF08538.5 ERZ96190.1 - 3.2e-05 22.9 0.0 4.5e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) BAAT_C PF08840.6 ERZ96190.1 - 0.00019 21.2 0.0 0.00025 20.8 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.15 ERZ96190.1 - 0.0075 15.8 0.1 0.16 11.5 0.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.13 ERZ96190.1 - 0.0083 15.5 0.0 0.46 9.8 0.0 2.2 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DUF915 PF06028.6 ERZ96190.1 - 0.023 13.7 0.1 0.061 12.4 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) UPF0227 PF05728.7 ERZ96190.1 - 0.088 12.5 0.2 0.17 11.5 0.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) MARVEL PF01284.18 ERZ96191.1 - 1.9e-05 24.4 13.6 2.9e-05 23.9 9.4 1.3 1 0 0 1 1 1 1 Membrane-associating domain NAD_binding_11 PF14833.1 ERZ96192.1 - 5.6e-32 110.3 0.0 1.1e-31 109.3 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.10 ERZ96192.1 - 1.6e-30 106.1 0.1 2.3e-30 105.5 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Isochorismatase PF00857.15 ERZ96193.1 - 3.7e-28 98.6 0.1 7.8e-28 97.5 0.0 1.5 2 0 0 2 2 2 1 Isochorismatase family HTH_Tnp_Tc5 PF03221.11 ERZ96193.1 - 6.7e-16 57.8 0.2 1.5e-15 56.7 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ERZ96193.1 - 0.0018 17.6 2.9 0.0035 16.7 2.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.17 ERZ96193.1 - 0.0024 17.6 0.2 0.005 16.6 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_23 PF13384.1 ERZ96193.1 - 0.0032 17.0 0.1 0.008 15.8 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain MarR PF01047.17 ERZ96193.1 - 0.013 15.1 0.0 0.034 13.8 0.0 1.7 1 0 0 1 1 1 0 MarR family HTH_19 PF12844.2 ERZ96193.1 - 0.043 13.8 0.4 0.13 12.3 0.3 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain UreF PF01730.11 ERZ96193.1 - 0.053 13.6 0.1 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 UreF HTH_28 PF13518.1 ERZ96193.1 - 0.11 12.5 0.0 0.38 10.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain zf-CCHC PF00098.18 ERZ96194.1 - 0.0086 15.9 0.8 0.012 15.4 0.6 1.3 1 0 0 1 1 1 1 Zinc knuckle Pkinase_Tyr PF07714.12 ERZ96195.1 - 0.00053 19.1 0.0 0.00054 19.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96195.1 - 0.025 13.7 0.3 0.026 13.6 0.2 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96196.1 - 4.1e-36 124.3 0.0 5e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96196.1 - 3.8e-35 121.3 0.0 4.8e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ96196.1 - 0.0057 16.4 0.0 0.0068 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ96196.1 - 0.014 14.7 0.1 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family WaaY PF06176.6 ERZ96196.1 - 0.018 14.2 0.3 0.03 13.5 0.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ERZ96196.1 - 0.028 13.4 0.1 0.041 12.9 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Solute_trans_a PF03619.11 ERZ96198.1 - 1.4e-55 188.5 25.0 1.7e-55 188.2 17.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha TPT PF03151.11 ERZ96199.1 - 0.1 12.2 11.6 0.13 11.9 0.1 3.3 3 0 0 3 3 3 0 Triose-phosphate Transporter family SNF2_N PF00176.18 ERZ96200.1 - 3.1e-41 141.1 0.1 3.6e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ERZ96200.1 - 1.2e-06 28.1 0.0 1.4e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.10 ERZ96200.1 - 0.00068 19.0 0.1 0.0008 18.8 0.1 1.3 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.10 ERZ96200.1 - 0.0012 18.6 0.0 0.0016 18.3 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit WD40 PF00400.27 ERZ96202.1 - 5.2e-27 92.7 17.6 8.7e-08 31.7 1.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 ERZ96202.1 - 0.00013 20.2 0.2 0.21 9.6 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoplasmin PF03066.10 ERZ96202.1 - 0.094 12.2 1.9 0.15 11.5 1.3 1.4 1 0 0 1 1 1 0 Nucleoplasmin PDZ_1 PF12812.2 ERZ96203.1 - 2.8e-33 113.6 0.0 8.4e-25 86.4 0.0 2.7 2 0 0 2 2 2 2 PDZ-like domain PDZ_2 PF13180.1 ERZ96203.1 - 2e-14 53.2 0.1 4e-05 23.4 0.0 4.6 4 0 0 4 4 4 2 PDZ domain Trypsin_2 PF13365.1 ERZ96203.1 - 7.1e-11 42.1 0.0 1.7e-09 37.7 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ PF00595.19 ERZ96203.1 - 5.3e-05 23.3 0.7 0.28 11.4 0.0 3.1 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) GRASP55_65 PF04495.9 ERZ96203.1 - 0.035 14.1 0.0 3 7.8 0.0 2.6 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.1 ERZ96203.1 - 0.038 13.7 0.0 2.5 7.9 0.0 3.2 3 0 0 3 3 3 0 Tricorn protease PDZ domain Peptidase_S46 PF10459.4 ERZ96203.1 - 0.11 10.8 0.1 0.17 10.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase S46 AMP-binding_C PF13193.1 ERZ96204.1 - 1.5e-14 54.6 0.0 2.2e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sperm_Ag_HE2 PF05324.8 ERZ96204.1 - 0.032 14.1 0.5 0.092 12.6 0.0 1.8 2 0 0 2 2 2 0 Sperm antigen HE2 DUF4159 PF13709.1 ERZ96204.1 - 0.098 11.7 0.0 0.15 11.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4159) Raptor_N PF14538.1 ERZ96204.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain WD40 PF00400.27 ERZ96205.1 - 5.3e-15 54.6 17.1 0.00012 21.8 0.0 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat Peptidase_S49_N PF08496.5 ERZ96205.1 - 0.99 9.1 7.5 2.1 8.1 5.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3021 PF11457.3 ERZ96206.1 - 0.019 14.8 0.9 0.032 14.1 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) Arteri_Gl PF00951.13 ERZ96206.1 - 0.024 14.2 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein RE_LlaJI PF09563.5 ERZ96208.1 - 0.0085 14.8 0.1 0.016 13.9 0.0 1.4 2 0 0 2 2 2 1 LlaJI restriction endonuclease YcxB PF14317.1 ERZ96208.1 - 0.062 12.5 0.1 5.3 6.3 0.0 2.3 2 0 0 2 2 2 0 YcxB-like protein FAR1 PF03101.10 ERZ96209.1 - 3.6e-11 43.4 3.1 3.6e-11 43.4 2.2 3.3 3 1 0 3 3 3 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ERZ96209.1 - 0.016 14.7 1.0 1.7 8.2 0.5 2.8 2 0 0 2 2 2 0 MuDR family transposase Cys_rich_VLP PF14194.1 ERZ96209.1 - 0.058 13.1 0.2 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich VLP zf-CCHC PF00098.18 ERZ96209.1 - 6.4 6.8 9.5 0.18 11.7 2.0 2.0 2 0 0 2 2 2 0 Zinc knuckle adh_short PF00106.20 ERZ96210.1 - 1.8e-32 112.5 0.1 2.3e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ96210.1 - 6.4e-17 61.7 0.0 9.2e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ERZ96210.1 - 1.7e-09 37.8 0.7 2.1e-09 37.4 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 ERZ96210.1 - 5.3e-06 25.5 1.5 6.5e-06 25.2 1.0 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 ERZ96210.1 - 0.00032 20.2 0.8 0.0011 18.4 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 ERZ96210.1 - 0.00068 19.3 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 ERZ96210.1 - 0.0037 17.2 0.2 0.0061 16.5 0.1 1.6 1 1 0 1 1 1 1 NADH(P)-binding B12-binding PF02310.14 ERZ96210.1 - 0.013 15.3 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 B12 binding domain TrkA_N PF02254.13 ERZ96210.1 - 0.028 14.3 1.2 0.067 13.2 0.5 1.9 2 0 0 2 2 2 0 TrkA-N domain DUF2536 PF10750.4 ERZ96212.1 - 0.16 11.5 0.9 0.42 10.2 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) RVT_1 PF00078.22 ERZ96213.1 - 3e-07 30.0 0.0 5.3e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4344 PF14247.1 ERZ96214.1 - 0.035 13.7 0.1 0.1 12.2 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4344) PI3_PI4_kinase PF00454.22 ERZ96215.1 - 5.2e-40 137.3 0.0 4e-39 134.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase LRR_6 PF13516.1 ERZ96217.1 - 4.8e-16 56.9 4.3 0.0068 16.3 0.0 4.8 4 1 1 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.28 ERZ96217.1 - 1.5e-06 27.4 2.3 12 6.4 0.2 4.7 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_4 PF12799.2 ERZ96217.1 - 2e-06 27.2 1.6 0.047 13.3 0.0 3.3 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ERZ96217.1 - 2.1e-05 23.9 4.9 0.44 10.9 0.1 5.1 4 1 1 5 5 5 1 Leucine rich repeat LRR_8 PF13855.1 ERZ96217.1 - 6.5e-05 22.5 0.5 0.0023 17.6 0.0 2.6 3 0 0 3 3 3 1 Leucine rich repeat DUF1754 PF08555.5 ERZ96218.1 - 8.5e-11 42.3 21.5 2.8e-10 40.6 13.1 2.4 1 1 1 2 2 2 1 Eukaryotic family of unknown function (DUF1754) DUF1090 PF06476.7 ERZ96218.1 - 0.037 13.7 10.4 0.081 12.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) AIF-MLS PF14962.1 ERZ96218.1 - 0.045 13.4 3.4 0.057 13.0 2.3 1.1 1 0 0 1 1 1 0 Mitochondria Localisation Sequence DUF4297 PF14130.1 ERZ96218.1 - 0.064 13.1 5.9 0.073 13.0 4.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4297) Chalcone PF02431.10 ERZ96218.1 - 0.31 10.3 3.3 0.35 10.2 2.3 1.1 1 0 0 1 1 1 0 Chalcone-flavanone isomerase DUF4191 PF13829.1 ERZ96218.1 - 0.37 9.8 2.4 0.4 9.7 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3631 PF12307.3 ERZ96218.1 - 0.65 9.8 4.8 0.26 11.1 1.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3631) DUF3539 PF12058.3 ERZ96218.1 - 1.2 8.9 5.2 0.4 10.5 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3539) DUF999 PF06198.6 ERZ96218.1 - 5.2 6.8 6.2 2.4 7.9 1.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF999) Ninjurin PF04923.7 ERZ96220.1 - 0.26 11.0 1.4 0.34 10.6 0.2 1.8 2 0 0 2 2 2 0 Ninjurin BTB PF00651.26 ERZ96221.1 - 4.1e-10 39.6 0.0 8.8e-09 35.3 0.0 2.5 1 1 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96221.1 - 2.5e-06 27.5 0.2 1.8e-05 24.7 0.1 2.5 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ96221.1 - 9.6e-06 25.3 0.8 9.9e-05 22.1 0.3 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch TRAP-gamma PF07074.7 ERZ96222.1 - 0.014 14.9 0.3 0.014 14.9 0.2 1.0 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Ins_P5_2-kin PF06090.7 ERZ96223.1 - 0.017 14.1 0.1 0.019 14.0 0.1 1.1 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase UNC45-central PF11701.3 ERZ96223.1 - 0.086 12.4 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central DUF4646 PF15496.1 ERZ96226.1 - 0.041 13.9 0.1 5.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4646) Far-17a_AIG1 PF04750.9 ERZ96228.1 - 5.3e-36 123.6 21.1 6e-36 123.5 14.6 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein ArsC PF03960.10 ERZ96229.1 - 1.4e-11 44.4 1.6 2.2e-11 43.8 1.1 1.3 1 1 0 1 1 1 1 ArsC family DUF1687 PF07955.6 ERZ96229.1 - 1.5e-11 44.3 0.1 1.7e-11 44.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) XG_FTase PF03254.8 ERZ96231.1 - 1.3e-08 33.8 0.0 1.3e-08 33.8 0.0 1.0 1 0 0 1 1 1 1 Xyloglucan fucosyltransferase Med28 PF11594.3 ERZ96232.1 - 3.7 7.8 8.3 12 6.2 2.8 2.8 2 1 0 2 2 2 0 Mediator complex subunit 28 Acetyltransf_7 PF13508.1 ERZ96234.1 - 1.3e-12 47.6 0.0 2.2e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ERZ96234.1 - 5.1e-12 45.6 0.0 8e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ERZ96234.1 - 7.5e-07 29.2 0.0 9.7e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ERZ96234.1 - 0.0052 16.5 0.0 0.0087 15.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein DUF4286 PF14114.1 ERZ96234.1 - 0.093 13.0 0.0 8.1 6.7 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4286) Pkinase_Tyr PF07714.12 ERZ96235.1 - 7.5e-34 116.9 0.0 1e-17 64.1 0.0 2.8 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ96235.1 - 2.6e-28 98.9 0.0 9.3e-17 61.0 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ERZ96235.1 - 0.0045 16.7 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RNA_POL_M_15KD PF02150.11 ERZ96235.1 - 0.015 15.0 2.0 0.057 13.1 1.4 2.1 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit LETM1 PF07766.8 ERZ96236.1 - 0.032 13.2 0.8 0.042 12.9 0.4 1.3 1 1 0 1 1 1 0 LETM1-like protein Peptidase_S46 PF10459.4 ERZ96236.1 - 0.077 11.3 2.5 0.083 11.3 1.7 1.0 1 0 0 1 1 1 0 Peptidase S46 Attacin_C PF03769.10 ERZ96236.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Attacin, C-terminal region Spore_II_R PF09551.5 ERZ96236.1 - 1.2 9.2 5.1 11 6.1 0.7 2.6 2 1 1 3 3 3 0 Stage II sporulation protein R (spore_II_R) DUF4442 PF14539.1 ERZ96239.1 - 5e-21 75.0 0.0 6.1e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT PF03061.17 ERZ96239.1 - 0.02 14.9 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase superfamily ATP-synt_E_2 PF08112.6 ERZ96239.1 - 0.068 13.2 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 ATP synthase epsilon subunit Ribosomal_L1 PF00687.16 ERZ96240.1 - 2.2e-52 177.6 3.1 2.5e-52 177.4 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PP_kinase PF02503.12 ERZ96240.1 - 0.09 12.2 0.0 0.38 10.2 0.0 2.0 1 1 0 1 1 1 0 Polyphosphate kinase middle domain FA_desaturase PF00487.19 ERZ96241.1 - 1.8e-44 152.1 24.6 2.7e-44 151.5 17.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 ERZ96241.1 - 1e-14 54.0 0.2 2e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MOSC PF03473.12 ERZ96242.1 - 1.1e-20 73.4 0.0 1.4e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 MOSC domain HALZ PF02183.13 ERZ96244.1 - 0.0018 17.9 5.4 0.0059 16.2 3.7 1.9 1 0 0 1 1 1 1 Homeobox associated leucine zipper TSC22 PF01166.13 ERZ96244.1 - 0.023 14.6 6.0 0.1 12.5 2.3 3.2 2 1 1 3 3 3 0 TSC-22/dip/bun family SlyX PF04102.7 ERZ96244.1 - 1.4 9.3 5.5 0.34 11.2 0.7 2.2 2 0 0 2 2 2 0 SlyX DivIVA PF05103.8 ERZ96244.1 - 2.9 7.9 16.1 0.43 10.6 6.2 3.0 2 1 1 3 3 3 0 DivIVA protein Pkinase_Tyr PF07714.12 ERZ96245.1 - 2.6e-31 108.6 0.0 4.3e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96245.1 - 3.7e-31 108.2 0.1 6.5e-31 107.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain GvpG PF05120.7 ERZ96245.1 - 0.052 13.3 0.4 0.18 11.6 0.3 1.9 1 0 0 1 1 1 0 Gas vesicle protein G TBCA PF02970.11 ERZ96245.1 - 0.081 13.0 2.6 0.11 12.6 0.3 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A Big_5 PF13205.1 ERZ96246.1 - 5.8e-06 26.8 5.0 1.6e-05 25.4 3.4 1.8 1 0 0 1 1 1 1 Bacterial Ig-like domain CP12 PF02672.10 ERZ96246.1 - 0.12 12.8 0.2 0.12 12.8 0.1 2.8 3 0 0 3 3 3 0 CP12 domain Histidinol_dh PF00815.15 ERZ96246.1 - 0.27 9.8 0.0 0.47 9.0 0.0 1.3 1 0 0 1 1 1 0 Histidinol dehydrogenase DsrD PF08679.6 ERZ96247.1 - 0.13 12.3 0.0 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) Glyco_hydro_14 PF01373.12 ERZ96249.1 - 0.1 11.3 0.1 0.11 11.1 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 AAA_18 PF13238.1 ERZ96249.1 - 1.1 9.5 5.1 1.3 9.3 3.5 1.1 1 0 0 1 1 1 0 AAA domain Cytochrome_C554 PF13435.1 ERZ96251.1 - 0.016 15.2 2.4 0.016 15.2 1.6 1.5 2 0 0 2 2 2 0 Cytochrome c554 and c-prime Cytochrom_c3_2 PF14537.1 ERZ96251.1 - 0.019 15.2 3.1 0.034 14.5 2.1 1.5 1 0 0 1 1 1 0 Cytochrome c3 DUF836 PF05768.9 ERZ96251.1 - 0.033 14.4 0.1 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) zf-CHY PF05495.7 ERZ96251.1 - 0.061 13.4 8.2 0.11 12.6 5.7 1.3 1 0 0 1 1 1 0 CHY zinc finger zf-HIT PF04438.11 ERZ96251.1 - 0.064 12.9 0.4 0.064 12.9 0.3 2.2 2 0 0 2 2 2 0 HIT zinc finger DZR PF12773.2 ERZ96251.1 - 0.069 12.9 4.1 0.13 12.1 2.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon RRN7 PF11781.3 ERZ96251.1 - 0.11 11.9 5.7 2.5 7.6 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Cytochrome_C7 PF14522.1 ERZ96251.1 - 2.6 7.7 8.1 6 6.5 5.6 1.7 1 1 0 1 1 1 0 Cytochrome c7 zf-FCS PF06467.9 ERZ96251.1 - 3.8 7.2 10.7 0.56 9.8 3.0 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif FYVE_2 PF02318.11 ERZ96251.1 - 5.4 6.9 11.1 3.9 7.4 4.6 2.2 1 1 1 2 2 2 0 FYVE-type zinc finger RPAP2_Rtr1 PF04181.8 ERZ96251.1 - 6.6 6.9 9.9 1.2 9.2 4.2 1.8 2 0 0 2 2 2 0 Rtr1/RPAP2 family CENP-B_dimeris PF09026.5 ERZ96252.1 - 0.17 12.1 3.2 0.31 11.2 2.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sorting_nexin PF03700.8 ERZ96252.1 - 1.3 9.1 7.7 0.59 10.2 0.3 2.6 1 1 1 2 2 2 0 Sorting nexin, N-terminal domain Laps PF10169.4 ERZ96252.1 - 2.4 8.4 8.7 1.4 9.1 0.2 2.0 1 1 1 2 2 2 0 Learning-associated protein MS_channel PF00924.13 ERZ96253.1 - 0.079 12.2 0.1 0.083 12.2 0.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel Toxin_64 PF15542.1 ERZ96255.1 - 0.059 13.9 0.9 0.07 13.7 0.6 1.2 1 0 0 1 1 1 0 Putative toxin 64 Nup54 PF13874.1 ERZ96256.1 - 0.0073 15.9 0.7 0.027 14.1 0.5 2.0 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 Phage_int_SAM_2 PF12834.2 ERZ96256.1 - 0.013 15.8 0.3 0.076 13.4 0.1 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal DUF4110 PF13422.1 ERZ96256.1 - 0.02 14.6 1.2 0.79 9.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) Phage_Gp111 PF07410.6 ERZ96256.1 - 2.4 8.3 8.3 0.84 9.8 0.3 3.3 3 0 0 3 3 3 0 Streptococcus thermophilus bacteriophage Gp111 protein DUF2779 PF11074.3 ERZ96256.1 - 2.7 8.0 15.8 4.6 7.2 0.7 3.7 1 1 0 2 2 2 0 Domain of unknown function(DUF2779) HCO3_cotransp PF00955.16 ERZ96259.1 - 0.52 8.9 2.7 1.2 7.7 1.9 1.6 1 0 0 1 1 1 0 HCO3- transporter family DDRGK PF09756.4 ERZ96259.1 - 2.3 7.5 33.7 6.1 6.2 23.3 1.7 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.7 ERZ96259.1 - 8.3 6.2 39.1 1.1 9.1 16.5 2.6 2 1 0 2 2 2 0 Ryanodine Receptor TM 4-6 SGL PF08450.7 ERZ96260.1 - 4e-29 101.7 0.3 5e-29 101.4 0.2 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region SBBP PF06739.6 ERZ96260.1 - 0.011 15.4 0.2 3.2 7.6 0.1 2.8 2 0 0 2 2 2 0 Beta-propeller repeat Lactonase PF10282.4 ERZ96260.1 - 0.031 13.3 0.0 0.054 12.5 0.0 1.5 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.15 ERZ96260.1 - 0.07 13.1 0.0 0.85 9.6 0.0 2.5 2 1 0 3 3 3 0 Arylesterase THOC7 PF05615.8 ERZ96263.1 - 2.9e-18 66.4 16.6 1e-17 64.7 9.8 2.4 2 0 0 2 2 2 1 Tho complex subunit 7 GTP_EFTU PF00009.22 ERZ96264.1 - 1.3e-55 187.7 0.0 2.4e-55 186.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 ERZ96264.1 - 1.3e-14 53.7 0.0 4.3e-14 52.1 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 ERZ96264.1 - 3.5e-10 39.8 0.0 1.2e-09 38.1 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 ERZ96264.1 - 1.6e-08 34.2 0.0 3.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 ERZ96264.1 - 9e-07 28.4 0.0 1.4e-05 24.6 0.0 2.7 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.18 ERZ96264.1 - 0.0038 17.1 0.0 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FHA PF00498.21 ERZ96265.1 - 6.1e-12 45.4 0.2 1.3e-11 44.4 0.1 1.6 1 0 0 1 1 1 1 FHA domain DUF2015 PF09435.5 ERZ96266.1 - 8.2e-33 112.9 0.0 9e-33 112.7 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) zf-LSD1 PF06943.7 ERZ96268.1 - 0.013 15.0 0.1 14 5.4 0.0 3.1 3 0 0 3 3 3 0 LSD1 zinc finger DUF2809 PF10990.3 ERZ96268.1 - 4.8 7.6 14.0 5.4 7.5 1.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2809) KRE9 PF05390.6 ERZ96269.1 - 6.9 7.0 12.6 3.2 8.1 1.3 2.9 1 1 2 3 3 3 0 Yeast cell wall synthesis protein KRE9/KNH1 Antimicrobial_1 PF08018.6 ERZ96269.1 - 8.3 6.3 7.7 72 3.4 0.2 3.4 3 0 0 3 3 3 0 Frog antimicrobial peptide HMG_box PF00505.14 ERZ96270.1 - 8.1e-16 58.0 0.2 9.5e-16 57.8 0.2 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ96270.1 - 6.8e-05 23.1 0.1 0.00011 22.5 0.1 1.4 1 1 0 1 1 1 1 HMG-box domain HMG_box_2 PF09011.5 ERZ96271.1 - 0.00081 19.7 3.3 0.0011 19.2 2.3 1.2 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.8 ERZ96271.1 - 0.0018 18.5 0.4 0.0021 18.3 0.3 1.1 1 0 0 1 1 1 1 YABBY protein PRANC PF09372.5 ERZ96271.1 - 0.0059 16.5 1.4 0.0071 16.2 1.0 1.2 1 0 0 1 1 1 1 PRANC domain DUF916 PF06030.7 ERZ96271.1 - 0.028 14.1 1.7 0.032 14.0 1.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) DUF4028 PF13220.1 ERZ96271.1 - 0.044 13.4 2.5 0.071 12.7 1.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4028) DUF4252 PF14060.1 ERZ96271.1 - 0.08 12.4 1.7 0.093 12.2 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) F-box-like PF12937.2 ERZ96274.1 - 0.0037 16.9 0.6 0.0095 15.6 0.4 1.7 1 0 0 1 1 1 1 F-box-like DUF3113 PF11310.3 ERZ96275.1 - 0.13 11.9 1.6 0.45 10.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3113) Peptidase_A22B PF04258.8 ERZ96276.1 - 1.8e-34 119.5 4.5 5.1e-34 118.0 3.1 1.8 1 1 0 1 1 1 1 Signal peptide peptidase Peptidase_A24 PF01478.13 ERZ96276.1 - 0.0046 17.1 8.7 0.07 13.3 0.8 2.6 2 1 0 2 2 2 2 Type IV leader peptidase family PRA1 PF03208.14 ERZ96276.1 - 8.4 5.7 9.2 0.15 11.3 1.2 1.9 2 1 0 2 2 2 0 PRA1 family protein Ofd1_CTDD PF10637.4 ERZ96277.1 - 4.5e-38 130.9 1.8 4.2e-33 114.6 0.5 3.3 2 2 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 ERZ96277.1 - 1.9e-16 60.3 0.6 1.5e-14 54.2 0.0 2.6 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily UPF0167 PF03691.9 ERZ96278.1 - 0.12 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) BRCA2 PF00634.13 ERZ96279.1 - 0.29 10.4 3.6 0.65 9.3 2.5 1.6 1 0 0 1 1 1 0 BRCA2 repeat BrkDBD PF09607.5 ERZ96280.1 - 0.052 13.1 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 Brinker DNA-binding domain Exo_endo_phos_2 PF14529.1 ERZ96281.1 - 0.00014 21.4 0.4 0.00047 19.7 0.1 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ96282.1 - 0.0045 16.9 0.0 0.0056 16.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Tox-MPTase2 PF15638.1 ERZ96282.1 - 0.03 13.8 0.7 0.035 13.6 0.5 1.1 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Eaf7 PF07904.8 ERZ96282.1 - 0.094 12.7 0.1 0.19 11.7 0.0 1.6 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 RRM_1 PF00076.17 ERZ96283.1 - 3.3e-05 23.4 0.4 0.0061 16.1 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ96283.1 - 0.0002 21.2 0.0 0.024 14.5 0.0 2.7 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ERZ96283.1 - 0.0017 18.2 2.2 0.0035 17.2 1.5 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ERZ96283.1 - 0.017 14.5 0.8 0.039 13.4 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 ERZ96283.1 - 2.2 7.9 5.2 0.58 9.8 0.8 2.2 2 0 0 2 2 2 0 Zinc knuckle PLRV_ORF5 PF01690.12 ERZ96285.1 - 0.32 10.1 28.7 0.34 9.9 19.9 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Utp14 PF04615.8 ERZ96285.1 - 0.95 7.5 35.7 0.99 7.4 24.8 1.0 1 0 0 1 1 1 0 Utp14 protein SDA1 PF05285.7 ERZ96285.1 - 6.6 5.9 44.5 9.2 5.4 30.9 1.3 1 0 0 1 1 1 0 SDA1 Pox_A28 PF04584.9 ERZ96286.1 - 0.1 12.4 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Poxvirus A28 family Wbp11 PF09429.5 ERZ96288.1 - 2.2e-16 59.5 12.9 2.2e-16 59.5 8.9 2.4 2 0 0 2 2 2 1 WW domain binding protein 11 NpwBP PF12622.2 ERZ96288.1 - 1.2e-07 32.1 3.8 1.2e-07 32.1 2.7 4.1 3 1 1 4 4 4 1 mRNA biogenesis factor BID PF06393.6 ERZ96288.1 - 0.33 10.2 4.4 0.13 11.6 0.2 2.1 2 0 0 2 2 2 0 BH3 interacting domain (BID) DUF2338 PF10100.4 ERZ96289.1 - 0.039 12.3 0.2 0.076 11.3 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2338) WD40 PF00400.27 ERZ96289.1 - 0.095 12.6 0.1 8.8 6.3 0.0 3.5 4 0 0 4 4 4 0 WD domain, G-beta repeat MFS_1 PF07690.11 ERZ96290.1 - 1.8e-40 138.7 44.3 3.6e-39 134.4 31.1 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 ERZ96290.1 - 7.3e-17 60.7 18.7 1e-16 60.2 12.9 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 ERZ96290.1 - 1.7e-11 43.4 11.2 1.7e-11 43.4 7.8 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.8 ERZ96290.1 - 0.0011 17.1 2.1 0.0011 17.1 1.4 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector CobT PF06213.7 ERZ96291.1 - 6.7 5.7 28.1 9.3 5.2 19.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_I_TF PF04090.7 ERZ96292.1 - 1.7e-10 40.5 0.7 1.7e-09 37.2 0.1 2.0 1 1 1 2 2 2 1 RNA polymerase I specific initiation factor DUF3808 PF10300.4 ERZ96292.1 - 0.078 11.5 0.5 0.1 11.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) MEA1 PF06910.6 ERZ96293.1 - 0.018 14.7 6.2 0.099 12.3 0.2 2.0 1 1 1 2 2 2 0 Male enhanced antigen 1 (MEA1) SPT6_acidic PF14632.1 ERZ96293.1 - 0.079 13.1 4.1 0.11 12.6 2.8 1.2 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Pox_Ag35 PF03286.9 ERZ96293.1 - 0.33 10.4 3.0 0.39 10.2 2.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HSP70 PF00012.15 ERZ96294.1 - 2.1e-247 821.8 9.0 2.4e-247 821.7 6.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ96294.1 - 1.7e-20 72.8 0.1 2.3e-19 69.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.5 ERZ96294.1 - 0.00095 18.0 1.4 0.038 12.8 0.1 2.8 3 0 0 3 3 3 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 ERZ96294.1 - 0.0015 17.7 0.1 0.033 13.2 0.1 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase FGGY_C PF02782.11 ERZ96294.1 - 0.0078 15.8 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 ERZ96294.1 - 0.012 15.4 0.3 0.31 10.8 0.2 3.1 1 1 0 1 1 1 0 Cell division protein FtsA StbA PF06406.6 ERZ96294.1 - 0.019 13.9 0.0 0.063 12.2 0.0 1.9 1 0 0 1 1 1 0 StbA protein eIF3_N PF09440.5 ERZ96294.1 - 0.56 10.3 7.0 0.54 10.4 2.7 2.3 2 1 0 2 2 2 0 eIF3 subunit 6 N terminal domain Dimer_Tnp_hAT PF05699.9 ERZ96295.1 - 0.042 13.4 0.1 0.064 12.8 0.0 1.5 1 1 0 1 1 1 0 hAT family C-terminal dimerisation region UBA_e1_thiolCys PF10585.4 ERZ96295.1 - 3.8 6.9 5.4 0.6 9.5 0.6 1.9 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site Rotamase PF00639.16 ERZ96296.1 - 7.5e-24 84.2 0.0 9.3e-24 83.9 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 ERZ96296.1 - 7.5e-16 58.4 0.0 9e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 ERZ96296.1 - 1e-05 25.2 0.3 1e-05 25.2 0.2 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.1 ERZ96296.1 - 0.00014 22.5 0.0 0.00017 22.1 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain adh_short PF00106.20 ERZ96297.1 - 3.1e-14 53.2 0.0 1.9e-10 40.9 0.0 2.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ96297.1 - 1.2e-06 28.3 0.0 4e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 ERZ96297.1 - 4.5e-05 23.3 0.0 0.0006 19.6 0.0 2.0 1 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ERZ96297.1 - 0.0071 15.8 0.1 1.6 8.0 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family PEX11 PF05648.9 ERZ96300.1 - 0.056 12.6 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Tetraspannin PF00335.15 ERZ96300.1 - 0.86 8.8 10.6 1 8.5 7.4 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF4519 PF15012.1 ERZ96301.1 - 0.21 11.5 3.7 0.51 10.3 2.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) SPARC_Ca_bdg PF10591.4 ERZ96301.1 - 5.1 7.1 9.3 0.63 10.0 2.9 2.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Sel1 PF08238.7 ERZ96305.1 - 6.8e-44 147.3 7.1 5.8e-11 42.6 0.4 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_20 PF14561.1 ERZ96305.1 - 0.21 11.7 1.5 1.6 8.8 0.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 ERZ96305.1 - 0.3 11.0 5.6 6.3 6.7 1.0 3.7 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Drf_GBD PF06371.8 ERZ96306.1 - 5.6e-42 143.2 1.7 5.6e-42 143.2 1.2 1.9 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 ERZ96306.1 - 1.7e-28 99.3 1.5 1.4e-14 53.9 0.0 3.2 1 1 2 3 3 3 2 Diaphanous FH3 Domain DUF4250 PF14056.1 ERZ96306.1 - 0.29 10.8 4.1 8.2 6.2 0.1 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4250) Fucose_iso_N2 PF07882.7 ERZ96306.1 - 0.6 9.7 0.0 0.6 9.7 0.0 2.7 2 1 1 3 3 3 0 L-fucose isomerase, second N-terminal domain CALCOCO1 PF07888.6 ERZ96306.1 - 4.4 5.4 19.0 0.6 8.3 10.4 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.7 ERZ96306.1 - 6 6.6 9.7 0.27 11.0 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TBPIP PF07106.8 ERZ96306.1 - 8.6 5.8 15.2 21 4.5 10.5 1.6 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ubiquitin PF00240.18 ERZ96307.1 - 2e-203 658.2 40.4 8.2e-34 114.8 0.7 6.0 6 0 0 6 6 6 6 Ubiquitin family Rad60-SLD PF11976.3 ERZ96307.1 - 3.5e-115 375.8 38.3 4.4e-19 67.9 0.7 6.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ96307.1 - 1.8e-35 121.0 20.8 0.00017 21.8 0.1 8.0 6 6 0 6 6 6 6 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ERZ96307.1 - 8.8e-31 106.7 3.6 0.0022 17.6 0.0 6.0 6 0 0 6 6 6 6 Telomere stability and silencing DUF2407 PF10302.4 ERZ96307.1 - 3.8e-20 71.8 6.4 0.14 12.3 0.0 6.2 1 1 4 6 6 6 6 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ERZ96307.1 - 1.1e-18 67.1 10.1 0.12 12.2 0.0 7.0 6 0 0 6 6 6 6 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 ERZ96307.1 - 1.3e-15 57.1 0.0 2.6 8.1 0.0 6.9 6 0 0 6 6 6 6 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 ERZ96307.1 - 7.7e-13 48.1 12.3 1.4 8.9 0.0 6.2 6 0 0 6 6 6 6 GLUT4 regulating protein TUG DUF3221 PF11518.3 ERZ96307.1 - 3.3e-09 36.3 6.2 8.1 6.1 0.0 6.0 6 0 0 6 6 6 1 Protein of unknown function (DUF3221) Plexin_cytopl PF08337.7 ERZ96307.1 - 5.2e-09 34.9 23.9 0.58 8.4 0.2 7.7 7 4 0 7 7 7 6 Plexin cytoplasmic RasGAP domain FlgD_ig PF13860.1 ERZ96307.1 - 1.4e-07 31.1 10.9 13 5.6 0.0 6.3 6 0 0 6 6 6 0 FlgD Ig-like domain RA PF00788.18 ERZ96307.1 - 4.5e-06 27.0 1.6 74 3.9 0.0 6.2 6 0 0 6 6 6 0 Ras association (RalGDS/AF-6) domain ACT_4 PF13291.1 ERZ96307.1 - 5.5e-06 26.6 2.6 84 3.6 0.0 6.1 6 0 0 6 6 6 0 ACT domain USP7_C2 PF14533.1 ERZ96307.1 - 2.3e-05 23.9 10.6 7.3 5.9 0.0 5.8 1 1 1 6 6 6 1 Ubiquitin-specific protease C-terminal ANTAR PF03861.9 ERZ96307.1 - 0.00028 20.4 0.2 1e+02 2.5 0.0 5.7 6 0 0 6 6 6 0 ANTAR domain Tash_PEST PF07708.6 ERZ96307.1 - 0.014 15.3 44.2 5.5 7.0 1.2 6.3 6 0 0 6 6 6 0 Tash protein PEST motif CDC48_2 PF02933.12 ERZ96307.1 - 0.024 14.2 26.4 11 5.7 0.2 6.2 6 0 0 6 6 6 0 Cell division protein 48 (CDC48), domain 2 FERM_N PF09379.5 ERZ96307.1 - 0.4 10.7 23.1 42 4.2 0.2 8.0 6 5 0 6 6 6 0 FERM N-terminal domain Kelch_4 PF13418.1 ERZ96308.1 - 2.7e-38 129.4 5.1 6.6e-11 41.8 0.2 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ERZ96308.1 - 3e-34 116.4 5.2 9.7e-08 31.8 0.2 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ERZ96308.1 - 4.5e-34 115.7 6.7 5.7e-10 38.5 1.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.1 ERZ96308.1 - 2.9e-33 113.2 2.6 9.7e-10 38.3 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ96308.1 - 2.6e-27 93.8 10.1 1.6e-09 37.4 0.4 6.4 4 1 2 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ERZ96308.1 - 7.6e-20 69.8 3.1 2.5e-07 30.1 0.1 6.4 6 0 0 6 6 6 4 Kelch motif DUF676 PF05057.9 ERZ96309.1 - 6e-12 45.3 1.1 9e-07 28.3 0.1 2.2 1 1 1 2 2 2 2 Putative serine esterase (DUF676) MMR_HSR1 PF01926.18 ERZ96311.1 - 1.5e-08 34.5 0.0 7.6e-08 32.3 0.0 2.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ERZ96311.1 - 0.00035 19.7 0.1 0.0032 16.6 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ERZ96311.1 - 0.0012 18.3 0.0 0.0033 16.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 ERZ96311.1 - 0.0023 18.0 0.1 0.27 11.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA PF00004.24 ERZ96311.1 - 0.0082 16.3 0.5 0.56 10.4 0.0 3.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ERZ96311.1 - 0.035 14.9 0.7 0.51 11.1 0.0 3.3 2 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ96311.1 - 0.045 13.2 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SE PF00437.15 ERZ96311.1 - 0.051 12.4 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Dynamin_N PF00350.18 ERZ96311.1 - 0.052 13.3 9.5 3.5 7.3 0.0 4.8 4 1 0 4 4 4 0 Dynamin family AAA_16 PF13191.1 ERZ96311.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 ERZ96311.1 - 0.11 12.7 0.0 0.11 12.7 0.0 3.1 3 1 0 3 3 3 0 ABC transporter AAA_18 PF13238.1 ERZ96311.1 - 4.4 7.6 10.7 0.96 9.7 0.0 4.1 3 1 0 3 3 3 0 AAA domain Dna2 PF08696.6 ERZ96312.1 - 0.17 11.2 2.0 2.8 7.1 0.0 2.1 2 0 0 2 2 2 0 DNA replication factor Dna2 DUF2508 PF10704.4 ERZ96312.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) GrpE PF01025.14 ERZ96312.1 - 0.26 10.8 11.1 0.083 12.4 4.7 1.9 1 1 1 2 2 2 0 GrpE Fzo_mitofusin PF04799.8 ERZ96312.1 - 0.48 9.7 6.6 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 fzo-like conserved region DUF3810 PF12725.2 ERZ96312.1 - 2.9 6.6 8.2 0.45 9.3 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) HTH_OrfB_IS605 PF12323.3 ERZ96313.1 - 0.11 11.7 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain ETC_C1_NDUFA5 PF04716.9 ERZ96314.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 ETC complex I subunit conserved region IQ PF00612.22 ERZ96315.1 - 0.011 15.3 0.4 0.019 14.5 0.3 1.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF905 PF06006.7 ERZ96316.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) Ecl1 PF12855.2 ERZ96316.1 - 0.24 10.7 3.8 0.47 9.7 2.6 1.5 1 1 0 1 1 1 0 Life-span regulatory factor Adeno_E4_34 PF04528.8 ERZ96317.1 - 0.051 13.1 0.5 0.061 12.9 0.3 1.2 1 0 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region AAA_35 PF14516.1 ERZ96318.1 - 0.024 13.2 0.0 0.042 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain RNase_H PF00075.19 ERZ96319.1 - 0.021 15.1 0.7 0.057 13.7 0.1 1.8 2 0 0 2 2 2 0 RNase H DUF4441 PF14536.1 ERZ96319.1 - 0.55 10.2 8.3 0.1 12.5 3.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) AAA_35 PF14516.1 ERZ96320.1 - 1.1e-13 50.5 0.0 2.3e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 ERZ96320.1 - 1.4e-06 28.4 0.0 1.2e-05 25.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ96320.1 - 1.2e-05 25.2 0.0 2.9e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ96320.1 - 0.00098 19.3 0.0 0.0024 18.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ96320.1 - 0.001 19.1 0.1 0.019 14.9 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.17 ERZ96320.1 - 0.0031 16.4 0.0 0.0063 15.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain UPF0079 PF02367.12 ERZ96320.1 - 0.0044 16.6 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 ERZ96320.1 - 0.0066 16.1 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Arch_ATPase PF01637.13 ERZ96320.1 - 0.0075 15.9 0.0 0.033 13.9 0.0 2.1 1 1 0 1 1 1 1 Archaeal ATPase T2SE PF00437.15 ERZ96320.1 - 0.075 11.9 0.0 0.14 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein zf-RING_2 PF13639.1 ERZ96321.1 - 1.7e-15 56.5 4.8 3e-15 55.7 3.3 1.5 1 0 0 1 1 1 1 Ring finger domain PA PF02225.17 ERZ96321.1 - 3.7e-13 49.0 0.0 1e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.2 ERZ96321.1 - 3.7e-10 39.7 1.9 9e-10 38.5 1.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ERZ96321.1 - 4.1e-10 39.1 4.7 9.1e-10 38.0 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ERZ96321.1 - 6.8e-08 32.4 5.2 1.3e-07 31.5 3.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ96321.1 - 2.1e-07 30.5 3.4 3.6e-07 29.7 2.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ERZ96321.1 - 4.4e-06 26.2 5.2 7.7e-06 25.4 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ERZ96321.1 - 8.2e-05 22.3 2.2 0.0002 21.1 1.5 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 ERZ96321.1 - 0.0031 17.0 4.8 0.0055 16.2 3.3 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RINGv PF12906.2 ERZ96321.1 - 0.0065 16.4 2.3 0.0065 16.4 1.6 2.1 2 1 0 2 2 2 1 RING-variant domain DUF2681 PF10883.3 ERZ96321.1 - 0.023 14.8 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) NfeD PF01957.13 ERZ96321.1 - 0.03 14.4 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding PHD PF00628.24 ERZ96321.1 - 0.057 13.1 3.8 0.11 12.1 2.6 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.6 ERZ96321.1 - 0.068 13.1 3.5 0.14 12.1 2.5 1.6 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.3 ERZ96321.1 - 0.29 11.1 8.9 0.63 10.0 4.8 2.6 2 2 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 ERZ96321.1 - 0.4 10.5 4.4 1.2 9.0 3.0 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ERZ96321.1 - 1.6 8.4 6.6 5.2 6.8 0.2 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Helitron_like_N PF14214.1 ERZ96322.1 - 8.9e-05 22.2 0.1 9.8e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Sel1 PF08238.7 ERZ96323.1 - 3.7e-46 154.5 15.0 3.9e-12 46.4 0.8 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ERZ96323.1 - 0.01 16.2 12.4 1.6 9.3 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat KIP1 PF07765.7 ERZ96324.1 - 0.087 12.6 0.3 0.28 11.0 0.1 1.9 2 0 0 2 2 2 0 KIP1-like protein BTB PF00651.26 ERZ96325.1 - 5.3e-13 48.9 0.0 1.1e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96325.1 - 1.6e-11 44.3 0.6 4.6e-11 42.8 0.2 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ96325.1 - 0.00031 20.5 5.6 0.0012 18.6 1.6 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3592 PF12158.3 ERZ96326.1 - 0.00012 21.8 9.4 0.00012 21.8 6.5 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3592) Bac_small_YrzI PF09501.5 ERZ96326.1 - 0.88 9.5 4.6 4.8 7.1 0.0 2.7 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) DUF3377 PF11857.3 ERZ96326.1 - 2.2 7.9 4.8 0.77 9.4 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3377) Ifi-6-16 PF06140.8 ERZ96327.1 - 1.3e-12 47.3 22.6 2.9e-12 46.1 15.6 1.7 1 1 0 1 1 1 1 Interferon-induced 6-16 family DUF3392 PF11872.3 ERZ96327.1 - 0.0065 16.4 0.7 0.018 14.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3392) Peroxin-13_N PF04088.8 ERZ96327.1 - 0.088 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Peroxin 13, N-terminal region SpoVAB PF13782.1 ERZ96327.1 - 0.57 10.1 5.5 0.49 10.4 2.7 1.8 1 1 0 1 1 1 0 Stage V sporulation protein AB Mu-like_Pro PF10123.4 ERZ96328.1 - 0.07 12.5 0.2 0.074 12.5 0.1 1.2 1 0 0 1 1 1 0 Mu-like prophage I protein Tom37_C PF11801.3 ERZ96328.1 - 0.098 12.5 3.3 0.16 11.7 2.3 1.3 1 0 0 1 1 1 0 Tom37 C-terminal domain LMBR1 PF04791.11 ERZ96328.1 - 0.32 9.5 6.8 0.39 9.2 4.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein BTV_NS2 PF04514.7 ERZ96328.1 - 0.36 9.6 7.5 0.42 9.4 5.2 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF4407 PF14362.1 ERZ96328.1 - 0.67 8.8 3.0 0.81 8.5 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SPX PF03105.14 ERZ96328.1 - 1.5 8.5 10.4 1.9 8.1 7.2 1.1 1 0 0 1 1 1 0 SPX domain Fib_alpha PF08702.5 ERZ96328.1 - 7.4 6.6 10.3 12 6.0 7.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PBP1_TM PF14812.1 ERZ96328.1 - 8.6 6.7 12.0 21 5.5 8.3 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF454 PF04304.8 ERZ96330.1 - 0.13 12.3 0.3 0.19 11.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF454) Staphostatin_B PF09023.5 ERZ96330.1 - 0.48 10.2 9.9 0.7 9.7 3.0 2.3 1 1 1 2 2 2 0 Staphostatin B Kelch_5 PF13854.1 ERZ96331.1 - 6.8e-14 51.4 5.1 6.3e-07 29.2 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ERZ96331.1 - 3e-09 36.2 0.3 0.00074 19.1 0.1 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 ERZ96331.1 - 1.3e-07 31.2 6.1 4.6e-05 23.0 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Adeno_E3_CR2 PF02439.10 ERZ96331.1 - 1.6e-07 30.7 2.7 3.5e-07 29.6 1.8 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Kelch_6 PF13964.1 ERZ96331.1 - 4.4e-06 26.6 4.2 0.0073 16.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif EphA2_TM PF14575.1 ERZ96331.1 - 6.3e-05 23.2 0.0 0.00032 21.0 0.0 2.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.1 ERZ96331.1 - 0.00096 18.8 0.2 0.00096 18.8 0.2 2.3 2 1 0 2 2 2 1 TMEM154 protein family Shisa PF13908.1 ERZ96331.1 - 0.0017 18.5 0.3 0.0017 18.5 0.2 3.6 3 2 1 4 4 3 1 Wnt and FGF inhibitory regulator CD34_antigen PF06365.7 ERZ96331.1 - 0.0045 16.6 0.0 0.0094 15.6 0.0 1.5 1 0 0 1 1 1 1 CD34/Podocalyxin family Kelch_3 PF13415.1 ERZ96331.1 - 0.0055 16.8 17.2 0.01 15.9 0.0 6.1 6 1 0 6 6 6 1 Galactose oxidase, central domain DUF3609 PF12259.3 ERZ96331.1 - 0.023 13.3 0.0 0.033 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3609) FAM163 PF15069.1 ERZ96331.1 - 0.024 15.2 0.8 0.21 12.1 0.0 2.6 2 1 0 2 2 2 0 FAM163 family Syndecan PF01034.15 ERZ96331.1 - 0.034 13.7 0.0 0.092 12.4 0.0 1.7 1 0 0 1 1 1 0 Syndecan domain Rifin_STEVOR PF02009.11 ERZ96331.1 - 0.049 13.2 1.1 0.076 12.6 0.0 1.7 2 0 0 2 2 2 0 Rifin/stevor family Glycophorin_A PF01102.13 ERZ96331.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.6 2 1 1 3 3 3 0 Glycophorin A Kelch_1 PF01344.20 ERZ96331.1 - 0.56 9.7 9.3 0.8 9.3 0.0 3.7 4 0 0 4 4 4 0 Kelch motif Tetraspannin PF00335.15 ERZ96331.1 - 1.1 8.5 5.9 0.076 12.2 0.2 2.0 2 0 0 2 2 2 0 Tetraspanin family SET PF00856.23 ERZ96332.1 - 1.9e-05 25.0 0.0 4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 SET domain PIGA PF08288.7 ERZ96333.1 - 0.0053 17.0 2.9 0.046 14.0 0.1 3.2 3 0 0 3 3 3 1 PIGA (GPI anchor biosynthesis) F-box-like PF12937.2 ERZ96334.1 - 0.0013 18.4 1.0 0.0037 16.9 0.7 1.8 1 0 0 1 1 1 1 F-box-like HECT PF00632.20 ERZ96335.1 - 1.5e-96 323.2 0.1 3.9e-96 321.9 0.0 1.8 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF913 PF06025.7 ERZ96335.1 - 2.2e-95 319.6 3.1 2.2e-95 319.6 2.1 7.5 8 2 1 9 9 9 1 Domain of Unknown Function (DUF913) DUF908 PF06012.7 ERZ96335.1 - 2.3e-74 250.6 1.9 2.3e-74 250.6 1.3 4.8 6 1 0 6 6 6 1 Domain of Unknown Function (DUF908) DUF4414 PF14377.1 ERZ96335.1 - 1.7e-26 92.2 6.9 1.7e-26 92.2 4.8 5.9 4 1 0 4 4 4 1 Domain of unknown function (DUF4414) UBA PF00627.26 ERZ96335.1 - 5.8e-10 38.7 0.8 1.3e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 UBA/TS-N domain Cyclin PF08613.6 ERZ96335.1 - 0.0072 16.7 0.0 0.0072 16.7 0.0 3.8 4 0 0 4 4 4 1 Cyclin Arm PF00514.18 ERZ96335.1 - 0.01 15.6 2.9 0.034 13.9 0.0 3.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat ATG22 PF11700.3 ERZ96335.1 - 0.93 7.8 0.1 1.8 6.9 0.1 1.3 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like XFP_N PF09364.5 ERZ96336.1 - 5.7e-153 508.9 0.0 7.7e-153 508.5 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.5 ERZ96336.1 - 3.1e-70 235.7 0.0 5.2e-70 235.0 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.10 ERZ96336.1 - 8.1e-69 230.7 0.4 2.3e-68 229.3 0.1 1.8 2 0 0 2 2 2 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase TPP_enzyme_C PF02775.16 ERZ96336.1 - 0.017 14.7 0.1 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ish1 PF10281.4 ERZ96337.1 - 0.11 12.5 1.6 0.37 10.9 0.0 2.4 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Glycogen_syn PF05693.8 ERZ96338.1 - 0 1080.2 0.0 0 1080.0 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.6 ERZ96338.1 - 1.7e-07 30.9 0.0 3.8e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 ERZ96338.1 - 3.1e-07 29.9 0.0 5.5e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ERZ96338.1 - 2.4e-05 24.5 0.0 4.9e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Sec63 PF02889.11 ERZ96339.1 - 1.5e-46 159.1 1.9 1.9e-46 158.7 1.3 1.1 1 0 0 1 1 1 1 Sec63 Brl domain DnaJ PF00226.26 ERZ96339.1 - 3.7e-17 61.8 0.8 9.7e-17 60.4 0.5 1.8 1 0 0 1 1 1 1 DnaJ domain ATP_bind_1 PF03029.12 ERZ96340.1 - 2.7e-84 282.4 0.1 3.3e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 ERZ96340.1 - 0.00015 20.6 0.0 0.00028 19.7 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_10 PF12846.2 ERZ96340.1 - 0.00031 20.2 0.0 0.00055 19.4 0.0 1.5 2 0 0 2 2 2 1 AAA-like domain AAA_17 PF13207.1 ERZ96340.1 - 0.00046 20.9 0.2 0.0015 19.3 0.0 2.0 2 1 0 2 2 1 1 AAA domain MMR_HSR1 PF01926.18 ERZ96340.1 - 0.00056 19.8 0.1 0.003 17.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_19 PF13245.1 ERZ96340.1 - 0.0016 18.1 0.0 0.0036 17.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain MobB PF03205.9 ERZ96340.1 - 0.0036 17.0 0.0 0.013 15.1 0.0 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ERZ96340.1 - 0.0047 16.8 0.1 0.014 15.2 0.0 1.9 3 0 0 3 3 2 1 AAA domain KTI12 PF08433.5 ERZ96340.1 - 0.0071 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_30 PF13604.1 ERZ96340.1 - 0.0085 15.6 0.0 0.02 14.4 0.0 1.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 ERZ96340.1 - 0.0092 15.4 0.1 0.14 11.5 0.0 2.4 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 ERZ96340.1 - 0.011 15.0 0.0 0.03 13.7 0.0 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SE PF00437.15 ERZ96340.1 - 0.013 14.4 0.0 0.059 12.2 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein SRP54 PF00448.17 ERZ96340.1 - 0.015 14.7 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.1 ERZ96340.1 - 0.034 14.3 0.0 0.061 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ERZ96340.1 - 0.038 14.1 0.0 0.082 13.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 ERZ96340.1 - 0.053 13.4 0.2 0.21 11.5 0.0 2.1 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 ERZ96340.1 - 0.059 13.5 0.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.1 ERZ96340.1 - 0.16 12.3 3.6 0.19 12.0 0.1 2.8 3 1 0 3 3 3 0 AAA domain S1-P1_nuclease PF02265.11 ERZ96341.1 - 3.1e-66 223.5 0.0 3.4e-66 223.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease RHH_2 PF03693.9 ERZ96341.1 - 0.12 12.5 0.1 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0156) Thiolase_N PF00108.18 ERZ96342.1 - 1.4e-81 273.4 2.5 1.4e-81 273.4 1.7 1.9 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ERZ96342.1 - 9.6e-48 160.6 0.4 9.6e-48 160.6 0.2 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.5 ERZ96342.1 - 0.078 13.0 0.9 0.6 10.1 0.0 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PGP_phosphatase PF09419.5 ERZ96343.1 - 1.1e-49 168.0 0.0 1.2e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 ERZ96343.1 - 0.00066 19.3 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ERZ96343.1 - 0.012 16.0 0.0 2.3 8.5 0.1 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DUF755 PF05501.6 ERZ96344.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF2935 PF11155.3 ERZ96345.1 - 0.09 12.8 0.4 0.11 12.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Tup_N PF08581.5 ERZ96345.1 - 0.11 12.6 6.3 0.22 11.7 4.4 1.5 1 1 0 1 1 1 0 Tup N-terminal CCDC32 PF14989.1 ERZ96346.1 - 0.05 13.4 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing 32 F-box-like PF12937.2 ERZ96350.1 - 0.39 10.4 4.1 0.64 9.7 0.7 2.7 2 0 0 2 2 2 0 F-box-like DZR PF12773.2 ERZ96352.1 - 0.013 15.3 8.8 0.68 9.7 0.7 3.3 3 0 0 3 3 3 0 Double zinc ribbon NMD3 PF04981.8 ERZ96352.1 - 0.43 9.6 7.4 2.5 7.1 0.4 3.2 3 0 0 3 3 3 0 NMD3 family Thioredoxin_7 PF13899.1 ERZ96352.1 - 1.7 8.7 6.8 76 3.4 0.0 4.1 3 1 1 4 4 4 0 Thioredoxin-like Zn-ribbon_8 PF09723.5 ERZ96352.1 - 2.3 8.2 9.3 9.9 6.2 0.1 4.2 3 1 1 4 4 4 0 Zinc ribbon domain zf-ribbon_3 PF13248.1 ERZ96352.1 - 2.5 7.4 9.7 10 5.5 0.0 2.9 3 0 0 3 3 3 0 zinc-ribbon domain DnaJ_CXXCXGXG PF00684.14 ERZ96352.1 - 3.7 7.6 10.5 0.76 9.8 0.7 3.0 3 0 0 3 3 3 0 DnaJ central domain Sel1 PF08238.7 ERZ96353.1 - 6.8e-65 214.0 40.9 4.1e-09 36.7 0.0 12.5 12 1 0 12 12 12 9 Sel1 repeat PFO_beta_C PF12367.3 ERZ96353.1 - 0.28 11.1 4.6 0.64 9.9 0.1 3.9 3 1 0 3 3 3 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal TPR_11 PF13414.1 ERZ96353.1 - 0.99 9.1 25.3 2.8 7.6 0.2 6.1 3 3 2 5 5 5 0 TPR repeat TPR_6 PF13174.1 ERZ96353.1 - 1.7 9.2 17.5 6.6 7.4 0.1 7.4 9 0 0 9 9 9 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ERZ96354.1 - 6.9e-40 136.7 0.1 9.2e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96354.1 - 1.7e-34 119.1 0.5 2.4e-34 118.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ERZ96354.1 - 0.034 13.0 0.0 0.081 11.8 0.0 1.6 1 1 1 2 2 2 0 Kinase-like Endonuclease_7 PF02945.10 ERZ96356.1 - 0.013 15.2 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 Recombination endonuclease VII Sec34 PF04136.10 ERZ96359.1 - 1e-35 122.7 5.4 1e-35 122.7 3.7 2.3 2 0 0 2 2 2 1 Sec34-like family BAR PF03114.13 ERZ96359.1 - 0.0025 17.3 5.0 0.011 15.2 0.6 3.0 3 0 0 3 3 3 1 BAR domain Rootletin PF15035.1 ERZ96359.1 - 0.065 13.2 2.4 0.068 13.1 0.3 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion LMF1 PF06762.9 ERZ96360.1 - 0.064 12.0 0.1 0.073 11.8 0.1 1.0 1 0 0 1 1 1 0 Lipase maturation factor DUF655 PF04919.7 ERZ96363.1 - 0.0078 15.9 0.3 0.027 14.1 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF655) AAA_19 PF13245.1 ERZ96363.1 - 0.098 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain YfzA PF14118.1 ERZ96364.1 - 1.5 9.0 5.5 0.88 9.7 2.0 1.7 1 1 0 1 1 1 0 YfzA-like protein Uma2 PF05685.7 ERZ96365.1 - 1.8e-10 40.4 0.0 2.7e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-C2H2_4 PF13894.1 ERZ96365.1 - 0.037 14.3 1.2 0.094 13.0 0.9 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.7 ERZ96365.1 - 0.094 12.8 0.4 0.18 11.9 0.3 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF2884 PF11101.3 ERZ96367.1 - 0.01 15.1 2.5 0.14 11.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) Uso1_p115_C PF04871.8 ERZ96367.1 - 0.15 11.9 10.0 0.17 11.8 1.7 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Imm2 PF14426.1 ERZ96367.1 - 0.25 11.3 0.9 0.51 10.3 0.1 1.9 2 0 0 2 2 2 0 Immunity protein Imm2 DivIC PF04977.10 ERZ96367.1 - 1.2 8.7 6.2 4.6 6.7 0.4 2.7 2 1 0 2 2 2 0 Septum formation initiator DUF3552 PF12072.3 ERZ96367.1 - 1.5 7.9 12.5 0.4 9.8 3.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Myb_DNA-bind_3 PF12776.2 ERZ96367.1 - 2.1 9.0 9.0 4.7 7.9 0.6 3.2 1 1 2 3 3 3 0 Myb/SANT-like DNA-binding domain Uso1_p115_C PF04871.8 ERZ96368.1 - 0.0017 18.3 4.0 0.0017 18.3 2.8 2.1 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region AAA_13 PF13166.1 ERZ96368.1 - 0.0045 15.5 13.7 0.0057 15.1 9.5 1.0 1 0 0 1 1 1 1 AAA domain Apolipoprotein PF01442.13 ERZ96368.1 - 0.0063 16.0 3.3 0.0082 15.6 2.3 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF2357 PF09823.4 ERZ96368.1 - 0.025 13.6 2.7 0.033 13.2 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) DUF3584 PF12128.3 ERZ96368.1 - 0.081 10.2 9.5 0.1 9.8 6.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FlaC_arch PF05377.6 ERZ96368.1 - 0.1 12.5 0.9 2.9 7.8 0.1 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ADIP PF11559.3 ERZ96368.1 - 0.16 11.8 14.6 0.13 12.1 3.3 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Toxin_trans PF07952.7 ERZ96368.1 - 0.19 10.5 8.1 0.26 10.1 5.6 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Exonuc_VII_L PF02601.10 ERZ96368.1 - 0.36 9.9 5.8 0.48 9.5 4.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit cwf21 PF08312.7 ERZ96368.1 - 0.58 10.0 4.0 1.4 8.7 1.6 2.2 2 0 0 2 2 2 0 cwf21 domain DUF1043 PF06295.7 ERZ96368.1 - 0.74 9.4 7.1 1.2 8.7 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DivIC PF04977.10 ERZ96368.1 - 1.6 8.2 9.5 1.2 8.6 0.4 2.5 2 1 0 2 2 2 0 Septum formation initiator PGBA_C PF15437.1 ERZ96368.1 - 3.5 7.8 9.1 1.7 8.8 0.8 2.3 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Swi5 PF07061.6 ERZ96368.1 - 3.6 7.4 10.7 0.38 10.5 2.0 2.5 2 1 1 3 3 3 0 Swi5 DUF2762 PF10960.3 ERZ96368.1 - 4.8 6.9 8.7 10 5.8 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2762) Ax_dynein_light PF10211.4 ERZ96368.1 - 5.3 6.8 15.3 1.1 9.0 2.2 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain Fib_alpha PF08702.5 ERZ96368.1 - 6.6 6.8 11.1 11 6.0 7.2 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Pkinase_Tyr PF07714.12 ERZ96369.1 - 1.6e-20 73.2 0.3 2e-20 72.9 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96369.1 - 2.7e-20 72.5 3.9 3.3e-20 72.3 2.7 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ96369.1 - 0.0015 17.9 0.9 0.0026 17.1 0.6 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 ERZ96370.1 - 3.9e-08 32.6 0.0 5e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96370.1 - 4.1e-07 29.4 0.0 5e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1073 PF06381.6 ERZ96371.1 - 0.06 11.7 0.0 0.088 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1073) F_bP_aldolase PF01116.15 ERZ96371.1 - 0.099 11.7 0.7 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Fructose-bisphosphate aldolase class-II MetRS-N PF09635.5 ERZ96373.1 - 0.032 14.6 0.6 0.62 10.4 0.0 2.4 1 1 2 3 3 3 0 MetRS-N binding domain DUF1664 PF07889.7 ERZ96373.1 - 0.09 12.5 0.6 2.5 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FCH PF00611.18 ERZ96373.1 - 0.12 12.5 1.0 1.6 8.9 0.1 2.3 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain FPL PF09758.4 ERZ96374.1 - 0.0083 15.9 0.1 0.0095 15.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein PB1-F2 PF11986.3 ERZ96374.1 - 0.074 13.0 0.3 0.08 12.9 0.2 1.2 1 0 0 1 1 1 0 Influenza A Proapoptotic protein Pterin_4a PF01329.14 ERZ96374.1 - 0.15 11.8 0.5 0.25 11.0 0.2 1.5 1 1 1 2 2 2 0 Pterin 4 alpha carbinolamine dehydratase Sec39 PF08314.6 ERZ96376.1 - 1.7e-66 224.6 11.9 3.6e-65 220.2 8.2 2.1 1 1 0 1 1 1 1 Secretory pathway protein Sec39 Nbas_N PF15492.1 ERZ96376.1 - 4.8e-19 68.5 0.2 1.4e-11 44.0 0.0 2.8 2 1 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal WD40 PF00400.27 ERZ96376.1 - 0.033 14.1 0.1 1.4 8.9 0.1 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat F-box-like PF12937.2 ERZ96378.1 - 5.4e-09 35.6 1.0 1e-08 34.7 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ96378.1 - 5.1e-06 25.9 0.4 1e-05 25.0 0.3 1.5 1 0 0 1 1 1 1 F-box domain RNA_pol_3_Rpc31 PF11705.3 ERZ96378.1 - 8.1 6.2 24.7 0.24 11.3 5.3 2.8 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 Triabin PF03973.8 ERZ96380.1 - 0.093 12.3 0.1 0.21 11.2 0.0 1.5 1 1 0 1 1 1 0 Triabin MUG113 PF13455.1 ERZ96381.1 - 0.017 15.5 0.2 0.022 15.1 0.1 1.4 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 T5orf172 PF10544.4 ERZ96381.1 - 0.071 13.5 1.3 0.13 12.7 0.9 1.6 1 1 0 1 1 1 0 T5orf172 domain Ribosomal_L4 PF00573.17 ERZ96381.1 - 0.094 12.0 0.3 0.11 11.8 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family DUF1319 PF07028.6 ERZ96381.1 - 0.2 11.8 2.2 0.31 11.2 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Not1 PF04054.10 ERZ96382.1 - 2.4e-145 484.1 10.2 2.8e-145 483.9 4.4 2.8 1 1 1 2 2 2 2 CCR4-Not complex component, Not1 DUF3819 PF12842.2 ERZ96382.1 - 2.3e-57 192.7 3.1 1.3e-56 190.3 2.2 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) RrnaAD PF00398.15 ERZ96383.1 - 3.8e-46 157.2 0.6 4.4e-46 157.0 0.4 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF4312 PF14189.1 ERZ96383.1 - 0.003 17.3 0.3 0.0066 16.2 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4312) CbiA PF01656.18 ERZ96383.1 - 0.03 13.7 0.7 0.038 13.3 0.0 1.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1253 PF06862.7 ERZ96384.1 - 7.7e-141 469.4 13.9 5.9e-121 403.9 7.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1253) DUF896 PF05979.7 ERZ96385.1 - 1.2 8.7 4.3 0.33 10.5 0.8 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) DUF1762 PF08574.5 ERZ96386.1 - 2.9e-09 37.1 22.8 2.9e-09 37.1 15.8 2.8 1 1 0 2 2 2 1 Protein of unknown function (DUF1762) MIase PF02426.11 ERZ96386.1 - 0.23 11.2 1.3 3.9 7.3 0.2 2.3 1 1 1 2 2 2 0 Muconolactone delta-isomerase SNARE_assoc PF09335.6 ERZ96387.1 - 5.8e-08 32.9 3.0 5.8e-08 32.9 2.1 2.6 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF106 PF01956.11 ERZ96387.1 - 0.0039 16.7 0.0 0.085 12.3 0.0 2.5 2 0 0 2 2 2 1 Integral membrane protein DUF106 Topoisom_bac PF01131.15 ERZ96388.1 - 2.9e-101 339.2 0.0 4.5e-101 338.5 0.0 1.3 1 0 0 1 1 1 1 DNA topoisomerase Xpo1 PF08389.7 ERZ96388.1 - 1.8e-39 135.0 8.0 6.5e-39 133.2 4.5 2.7 2 0 0 2 2 2 1 Exportin 1-like protein Toprim PF01751.17 ERZ96388.1 - 7.7e-19 67.5 0.2 3.3e-18 65.5 0.0 2.3 2 0 0 2 2 2 1 Toprim domain IBN_N PF03810.14 ERZ96388.1 - 3.5e-10 39.6 4.1 4.7e-10 39.2 0.6 3.1 4 0 0 4 4 4 1 Importin-beta N-terminal domain DUF3385 PF11865.3 ERZ96388.1 - 0.0022 17.9 0.0 0.12 12.3 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3385) Cullin_Nedd8 PF10557.4 ERZ96388.1 - 0.28 11.0 3.2 1 9.2 0.1 3.5 4 0 0 4 4 4 0 Cullin protein neddylation domain Pkinase_Tyr PF07714.12 ERZ96389.1 - 2.9e-40 137.9 0.0 4.1e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96389.1 - 9.3e-36 123.2 0.0 3.4e-35 121.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Phage_Mu_Gp45 PF06890.7 ERZ96389.1 - 0.017 14.5 0.0 0.093 12.1 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage Mu Gp45 protein DUF3554 PF12074.3 ERZ96391.1 - 2.9e-55 188.0 2.8 2.9e-55 188.0 1.9 4.4 5 1 1 6 6 6 1 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 ERZ96391.1 - 3e-51 171.6 29.7 6.9e-09 35.8 0.0 16.5 11 5 3 15 15 15 10 HEAT repeats HEAT PF02985.17 ERZ96391.1 - 3.2e-51 166.8 27.6 0.0026 17.6 0.0 23.7 26 0 0 26 26 24 11 HEAT repeat HEAT_EZ PF13513.1 ERZ96391.1 - 8e-41 137.5 41.1 0.00097 19.5 0.0 23.4 18 4 8 26 26 25 11 HEAT-like repeat CLASP_N PF12348.3 ERZ96391.1 - 1.7e-19 70.1 0.0 0.00012 21.5 0.0 7.9 7 1 1 8 8 8 3 CLASP N terminal Vac14_Fab1_bd PF12755.2 ERZ96391.1 - 2e-18 66.5 5.9 0.21 11.9 0.0 11.1 9 2 3 12 12 12 5 Vacuolar 14 Fab1-binding region Cnd1 PF12717.2 ERZ96391.1 - 4.2e-13 49.5 4.1 0.057 13.2 0.0 9.4 8 1 0 9 9 9 3 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.4 ERZ96391.1 - 7.2e-09 35.7 2.5 0.15 11.9 0.0 6.5 7 1 0 7 7 7 2 Parkin co-regulated protein Ipi1_N PF12333.3 ERZ96391.1 - 5.9e-05 22.9 0.4 1.4 8.9 0.0 6.8 6 1 0 6 6 5 1 Rix1 complex component involved in 60S ribosome maturation Cohesin_HEAT PF12765.2 ERZ96391.1 - 0.00022 21.1 2.6 1.9 8.5 0.1 6.3 7 0 0 7 7 7 1 HEAT repeat associated with sister chromatid cohesion UNC45-central PF11701.3 ERZ96391.1 - 0.0026 17.4 3.0 0.011 15.4 0.2 3.6 5 0 0 5 5 5 1 Myosin-binding striated muscle assembly central Arm PF00514.18 ERZ96391.1 - 0.015 15.0 8.4 35 4.4 0.1 8.3 7 1 1 8 8 8 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.11 ERZ96391.1 - 1.5 9.5 12.2 82 4.1 0.0 8.4 8 1 0 8 8 6 0 PBS lyase HEAT-like repeat F-box-like PF12937.2 ERZ96392.1 - 0.00022 20.8 2.7 0.00044 19.9 1.0 2.2 3 0 0 3 3 3 1 F-box-like Chromo PF00385.19 ERZ96392.1 - 0.069 12.8 0.2 0.23 11.1 0.2 1.9 1 1 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain GAT PF03127.9 ERZ96392.1 - 0.15 12.0 0.0 0.53 10.2 0.0 1.9 2 0 0 2 2 2 0 GAT domain Dimer_Tnp_hAT PF05699.9 ERZ96394.1 - 3.7e-05 23.2 0.1 8.5e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ERZ96396.1 - 8e-18 64.4 0.0 3e-17 62.5 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96396.1 - 1.7e-16 60.2 1.7 3.8e-16 59.0 0.5 2.3 2 1 0 2 2 2 1 Protein kinase domain DUF3669 PF12417.3 ERZ96396.1 - 0.00037 20.1 0.5 3 7.6 0.1 4.0 4 0 0 4 4 4 2 Zinc finger protein DUF1451 PF07295.6 ERZ96396.1 - 0.92 9.2 13.7 2.3 7.9 0.3 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1451) Pkinase_Tyr PF07714.12 ERZ96398.1 - 1.8e-38 132.1 0.0 1.1e-31 109.8 0.0 4.1 4 0 0 4 4 4 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ96398.1 - 1.5e-33 116.1 7.3 7.7e-33 113.7 0.2 3.0 2 1 1 3 3 3 1 Protein kinase domain BCS1_N PF08740.6 ERZ96398.1 - 2.9e-09 36.8 0.0 0.056 13.0 0.0 4.3 4 0 0 4 4 4 3 BCS1 N terminal HypA PF01155.14 ERZ96398.1 - 0.023 14.3 6.8 2.2 8.0 0.0 3.4 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family Spt5-NGN PF03439.8 ERZ96398.1 - 0.12 12.1 3.9 27 4.6 0.0 4.1 4 0 0 4 4 4 0 Early transcription elongation factor of RNA pol II, NGN section DUF4413 PF14372.1 ERZ96398.1 - 0.32 11.0 4.3 0.45 10.5 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) zf-ribbon_3 PF13248.1 ERZ96398.1 - 0.36 10.0 7.7 5.9 6.2 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain ADK_lid PF05191.9 ERZ96398.1 - 0.67 9.6 11.7 7.4 6.3 0.1 4.5 4 0 0 4 4 4 0 Adenylate kinase, active site lid zinc_ribbon_2 PF13240.1 ERZ96398.1 - 3 7.4 11.3 7.8 6.1 0.8 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Nudix_N_2 PF14803.1 ERZ96398.1 - 7.7 6.2 9.7 2.3 7.9 0.5 3.3 3 0 0 3 3 3 0 Nudix N-terminal Pkinase_Tyr PF07714.12 ERZ96399.1 - 3.3e-20 72.2 0.0 2.3e-18 66.2 0.0 3.0 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96399.1 - 5.1e-20 71.7 0.7 5.1e-20 71.7 0.5 3.5 4 1 0 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ERZ96399.1 - 0.0017 17.9 0.0 0.6 9.6 0.0 2.5 2 0 0 2 2 2 2 BCS1 N terminal DUF4413 PF14372.1 ERZ96399.1 - 0.57 10.2 6.5 34 4.4 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) CDC45 PF02724.9 ERZ96399.1 - 0.78 7.6 17.6 1.4 6.8 12.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid PF03115.9 ERZ96399.1 - 3.6 5.7 10.9 7 4.7 7.6 1.4 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Pkinase_Tyr PF07714.12 ERZ96400.1 - 1.5e-21 76.6 1.1 4.4e-19 68.5 0.0 3.4 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96400.1 - 1.1e-19 70.6 0.4 1.1e-19 70.6 0.3 2.6 3 0 0 3 3 3 1 Protein kinase domain BCS1_N PF08740.6 ERZ96400.1 - 4.4e-06 26.4 0.4 0.15 11.6 0.0 3.6 3 0 0 3 3 3 2 BCS1 N terminal DUF4413 PF14372.1 ERZ96400.1 - 0.0002 21.2 6.9 0.97 9.4 0.2 5.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4413) APH PF01636.18 ERZ96400.1 - 0.24 11.0 0.0 0.38 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-DBF PF07535.7 ERZ96400.1 - 0.71 9.6 52.0 0.24 11.1 3.9 7.7 5 4 0 5 5 5 0 DBF zinc finger eIF-5_eIF-2B PF01873.12 ERZ96403.1 - 0.65 9.6 3.6 0.44 10.2 0.6 1.9 1 1 1 2 2 2 0 Domain found in IF2B/IF5 BTB PF00651.26 ERZ96407.1 - 3.7e-18 65.5 0.3 2.3e-17 63.0 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ96407.1 - 6.7e-09 35.5 0.4 1.9e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ96407.1 - 1.4e-08 34.8 5.1 3.7e-08 33.4 3.5 1.7 1 0 0 1 1 1 1 TLD DDE_1 PF03184.14 ERZ96408.1 - 4e-30 104.5 0.7 6.3e-30 103.9 0.5 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ96408.1 - 5.6e-12 45.2 0.0 1.4e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ERZ96408.1 - 7.1e-05 22.5 0.1 0.00012 21.8 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_1 PF01527.15 ERZ96408.1 - 0.0017 18.2 0.0 0.011 15.6 0.0 2.2 1 1 1 2 2 2 1 Transposase BrkDBD PF09607.5 ERZ96408.1 - 0.0069 15.9 0.1 0.022 14.3 0.1 1.8 1 0 0 1 1 1 1 Brinker DNA-binding domain CENP-B_N PF04218.8 ERZ96408.1 - 0.012 15.0 0.1 0.028 13.8 0.1 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain RNase_H PF00075.19 ERZ96409.1 - 5e-12 46.3 0.0 9.3e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 RNase H NusB PF01029.13 ERZ96409.1 - 0.064 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 NusB family EF_assoc_2 PF08356.7 ERZ96409.1 - 0.068 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 EF hand associated DUF3636 PF12331.3 ERZ96411.1 - 0.12 11.9 0.1 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) RNase_H PF00075.19 ERZ96412.1 - 0.0041 17.4 0.1 0.0064 16.8 0.1 1.3 1 0 0 1 1 1 1 RNase H TBCA PF02970.11 ERZ96418.1 - 2.3e-29 101.3 8.7 2.9e-29 100.9 6.0 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Phg_2220_C PF09524.5 ERZ96418.1 - 0.021 14.8 1.7 3.9 7.5 0.1 2.2 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) Exonuc_VII_S PF02609.11 ERZ96418.1 - 0.028 14.1 4.7 1.1 9.0 0.4 2.4 2 0 0 2 2 2 0 Exonuclease VII small subunit UvrD-helicase PF00580.16 ERZ96418.1 - 0.081 12.2 6.0 0.086 12.1 4.2 1.0 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Bul1_C PF04426.7 ERZ96418.1 - 0.13 11.4 3.8 0.098 11.8 0.4 1.8 1 1 1 2 2 2 0 Bul1 C terminus DASH_Dad3 PF08656.5 ERZ96418.1 - 0.14 11.8 1.2 4.5 7.0 0.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad3 DUF1940 PF09155.5 ERZ96418.1 - 0.19 11.5 1.4 0.26 11.1 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) V_ATPase_I PF01496.14 ERZ96418.1 - 0.2 9.4 5.9 0.23 9.2 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_19 PF14559.1 ERZ96418.1 - 0.22 11.8 1.7 7.9 6.8 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF342 PF03961.8 ERZ96418.1 - 1.3 7.3 7.4 1.5 7.1 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3498 PF12004.3 ERZ96418.1 - 1.3 8.0 8.8 1.5 7.8 6.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) RasGAP_C PF03836.10 ERZ96418.1 - 1.4 8.5 9.1 3.3 7.3 4.6 2.0 1 1 1 2 2 2 0 RasGAP C-terminus FlxA PF14282.1 ERZ96418.1 - 1.8 8.5 15.3 0.91 9.4 3.0 2.2 1 1 1 2 2 2 0 FlxA-like protein AAA_23 PF13476.1 ERZ96418.1 - 2.1 8.6 10.9 3.1 8.0 7.5 1.2 1 0 0 1 1 1 0 AAA domain DUF2458 PF10454.4 ERZ96418.1 - 2.4 8.0 9.9 0.45 10.3 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) Seryl_tRNA_N PF02403.17 ERZ96418.1 - 2.8 8.0 10.2 0.62 10.1 4.2 1.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1077 PF06417.7 ERZ96419.1 - 2e-49 166.1 3.7 2.7e-49 165.7 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) SNF2_N PF00176.18 ERZ96420.1 - 6e-84 281.3 1.9 9.4e-84 280.7 1.1 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ERZ96420.1 - 1.8e-12 46.9 0.0 4.4e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 ERZ96420.1 - 5.8e-07 29.1 5.8 1.1e-06 28.2 4.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ERZ96420.1 - 9.5e-07 28.5 4.9 2.3e-06 27.3 3.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ERZ96420.1 - 2.1e-06 27.6 4.5 6.4e-06 26.1 3.1 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ96420.1 - 0.00011 21.8 5.7 0.00022 20.8 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ERZ96420.1 - 0.00012 21.7 7.1 0.00026 20.5 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Bac_rhamnosid PF05592.6 ERZ96420.1 - 0.0021 16.3 0.6 0.0038 15.5 0.4 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase HDA2-3 PF11496.3 ERZ96420.1 - 0.0034 16.2 0.7 0.019 13.7 0.5 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 zf-RING_6 PF14835.1 ERZ96420.1 - 0.059 13.1 4.2 0.09 12.5 0.9 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 ERZ96420.1 - 2.9 7.8 8.7 49 3.9 6.2 2.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING HMG_box PF00505.14 ERZ96421.1 - 0.00012 22.2 1.5 0.00029 21.0 0.2 2.3 3 0 0 3 3 3 1 HMG (high mobility group) box Piwi PF02171.12 ERZ96423.1 - 8.7e-79 264.6 0.0 2.5e-76 256.5 0.1 2.3 2 0 0 2 2 2 2 Piwi domain PAZ PF02170.17 ERZ96423.1 - 7.5e-13 47.9 0.0 1.9e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 PAZ domain CDC45 PF02724.9 ERZ96424.1 - 3.5e-43 147.5 0.2 4.4e-43 147.2 0.2 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF3799 PF12684.2 ERZ96424.1 - 0.0036 16.6 0.4 0.0054 16.1 0.3 1.2 1 0 0 1 1 1 1 PDDEXK-like domain of unknown function (DUF3799) ABC_membrane PF00664.18 ERZ96425.1 - 1.1e-56 192.2 32.0 1.2e-31 110.2 6.9 3.8 4 1 0 4 4 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 ERZ96425.1 - 1.5e-53 180.7 0.0 4.5e-29 101.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ERZ96425.1 - 5.9e-12 45.2 1.6 0.00044 19.5 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ERZ96425.1 - 1.8e-07 31.7 3.8 0.00024 21.4 0.4 3.6 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.1 ERZ96425.1 - 5e-06 26.0 0.1 0.041 13.2 0.1 2.5 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 ERZ96425.1 - 8.3e-06 24.9 0.1 0.02 13.7 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.1 ERZ96425.1 - 1.1e-05 24.8 0.7 0.11 12.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_10 PF12846.2 ERZ96425.1 - 5.4e-05 22.7 0.1 0.1 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA-like domain AAA_22 PF13401.1 ERZ96425.1 - 9.7e-05 22.5 0.2 0.18 11.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 ERZ96425.1 - 0.00021 21.6 0.2 1.6 9.0 0.0 3.6 3 0 0 3 3 2 2 AAA domain FtsK_SpoIIIE PF01580.13 ERZ96425.1 - 0.0004 19.9 0.1 0.95 8.9 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family DUF258 PF03193.11 ERZ96425.1 - 0.001 18.2 0.0 0.13 11.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Miro PF08477.8 ERZ96425.1 - 0.0013 19.2 0.1 1.1 9.7 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein AAA_17 PF13207.1 ERZ96425.1 - 0.0014 19.4 5.8 0.88 10.4 0.8 3.1 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.12 ERZ96425.1 - 0.0027 17.5 0.9 0.063 13.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_33 PF13671.1 ERZ96425.1 - 0.0032 17.3 0.1 0.4 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ERZ96425.1 - 0.004 16.8 0.3 2.9 7.6 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 ERZ96425.1 - 0.0066 16.4 0.1 2.1 8.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 ERZ96425.1 - 0.0077 16.1 0.2 2.2 8.2 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.7 ERZ96425.1 - 0.009 15.1 0.1 0.91 8.5 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.7 ERZ96425.1 - 0.016 14.8 0.8 1.7 8.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.12 ERZ96425.1 - 0.017 14.5 1.2 4.9 6.5 0.1 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein RNA_helicase PF00910.17 ERZ96425.1 - 0.048 13.8 0.1 25 5.0 0.0 3.4 3 0 0 3 3 3 0 RNA helicase AAA_5 PF07728.9 ERZ96425.1 - 0.05 13.3 0.2 7.7 6.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.4 ERZ96425.1 - 0.054 12.0 0.5 4.2 5.8 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.14 ERZ96425.1 - 0.07 12.5 1.1 1.3 8.4 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 ERZ96425.1 - 0.11 12.7 0.4 3.3 7.9 0.0 3.4 5 0 0 5 5 3 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.10 ERZ96425.1 - 0.11 12.2 0.0 20 4.9 0.0 2.7 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit DEAD PF00270.24 ERZ96425.1 - 0.26 10.7 1.4 13 5.2 0.0 3.6 4 0 0 4 4 4 0 DEAD/DEAH box helicase AAA_19 PF13245.1 ERZ96425.1 - 0.31 10.8 0.4 2.1 8.1 0.1 2.3 2 0 0 2 2 2 0 Part of AAA domain DUF3959 PF13105.1 ERZ96429.1 - 0.079 12.2 1.1 0.084 12.1 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Pox_I5 PF04713.7 ERZ96432.1 - 0.055 13.1 1.0 0.067 12.9 0.6 1.3 1 1 0 1 1 1 0 Poxvirus protein I5 Phi-29_GP16_7 PF06720.6 ERZ96433.1 - 0.077 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Pkinase_Tyr PF07714.12 ERZ96435.1 - 2.5e-45 154.5 0.3 1.9e-36 125.4 0.0 5.1 4 1 0 5 5 5 4 Protein tyrosine kinase Pkinase PF00069.20 ERZ96435.1 - 4.1e-35 121.1 0.1 4.1e-35 121.1 0.0 3.5 5 0 0 5 5 5 1 Protein kinase domain BCS1_N PF08740.6 ERZ96435.1 - 0.014 15.0 0.0 0.4 10.2 0.0 2.9 3 0 0 3 3 3 0 BCS1 N terminal APH PF01636.18 ERZ96435.1 - 0.041 13.6 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NAD_binding_6 PF08030.7 ERZ96436.1 - 2.4 8.0 7.9 2.3 8.0 0.2 2.5 2 0 0 2 2 2 0 Ferric reductase NAD binding domain V_ATPase_I PF01496.14 ERZ96436.1 - 2.5 5.8 14.3 1.4 6.6 8.9 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4446 PF14584.1 ERZ96436.1 - 7.7 6.3 10.5 0.97 9.2 3.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Pkinase_Tyr PF07714.12 ERZ96437.1 - 2.1e-20 72.9 0.7 1.7e-18 66.6 0.0 3.9 5 0 0 5 5 5 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96437.1 - 5.2e-18 65.1 0.7 5.2e-18 65.1 0.5 3.0 3 0 0 3 3 3 1 Protein kinase domain V-SNARE PF05008.10 ERZ96437.1 - 0.3 11.2 0.0 0.3 11.2 0.0 5.1 6 0 0 6 6 6 0 Vesicle transport v-SNARE protein N-terminus EF-hand_4 PF12763.2 ERZ96438.1 - 6.5e-28 96.5 0.0 1.3e-16 60.2 0.0 2.9 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Drf_FH1 PF06346.7 ERZ96438.1 - 3.8e-12 46.0 68.5 8.5e-12 44.8 47.5 1.6 1 0 0 1 1 1 1 Formin Homology Region 1 WH2 PF02205.15 ERZ96438.1 - 4.6e-11 41.9 0.5 1.1e-10 40.7 0.4 1.7 1 0 0 1 1 1 1 WH2 motif EF-hand_7 PF13499.1 ERZ96438.1 - 1.3e-09 38.0 0.0 3.5e-06 27.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ERZ96438.1 - 5.1e-05 22.2 0.0 0.0021 17.2 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 ERZ96438.1 - 0.00047 19.8 0.0 1.2 9.1 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ERZ96438.1 - 0.0028 17.2 0.0 0.13 11.8 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair RhoGEF PF00621.15 ERZ96439.1 - 6.3e-26 91.3 4.3 6.3e-26 91.3 3.0 1.5 2 0 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.23 ERZ96439.1 - 3.6e-20 71.0 2.5 5.2e-14 51.3 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.1 ERZ96439.1 - 4e-19 67.9 0.7 1.7e-11 43.4 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.12 ERZ96439.1 - 4.3e-18 64.5 0.1 1.5e-10 40.4 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 ERZ96439.1 - 0.05 13.7 0.2 0.05 13.7 0.1 1.8 2 0 0 2 2 2 0 Bacterial SH3 domain DUF3741 PF12552.3 ERZ96442.1 - 0.07 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) Herpes_UL25 PF01499.11 ERZ96443.1 - 0.00085 17.7 3.3 0.0011 17.4 2.3 1.3 1 0 0 1 1 1 1 Herpesvirus UL25 family DivIC PF04977.10 ERZ96443.1 - 0.65 9.5 18.2 2.9 7.4 4.3 4.1 1 1 2 3 3 3 0 Septum formation initiator TSC22 PF01166.13 ERZ96443.1 - 1.6 8.7 21.5 0.79 9.7 5.3 4.6 3 2 0 3 3 3 0 TSC-22/dip/bun family Leucyl-specific PF14795.1 ERZ96443.1 - 3 7.7 8.6 5 7.0 0.4 2.9 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain DUF2344 PF10105.4 ERZ96443.1 - 4 6.8 11.1 1.6 8.2 4.8 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) Baculo_PEP_C PF04513.7 ERZ96444.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vac_Fusion PF02346.11 ERZ96444.1 - 0.018 14.4 0.2 1.3 8.4 0.0 3.1 1 1 1 2 2 2 0 Chordopoxvirus fusion protein IncA PF04156.9 ERZ96444.1 - 0.036 13.6 0.0 0.074 12.6 0.0 1.5 1 1 0 1 1 1 0 IncA protein Prefoldin_2 PF01920.15 ERZ96444.1 - 0.049 13.3 0.0 5.7 6.7 0.0 2.3 1 1 1 2 2 2 0 Prefoldin subunit ADIP PF11559.3 ERZ96444.1 - 0.052 13.4 0.0 0.18 11.7 0.0 1.9 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding GST_C_2 PF13410.1 ERZ96444.1 - 0.082 12.8 0.5 1.7 8.5 0.1 2.4 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain XhlA PF10779.4 ERZ96444.1 - 0.094 12.6 0.0 5.5 6.9 0.0 2.5 1 1 1 2 2 2 0 Haemolysin XhlA SlyX PF04102.7 ERZ96444.1 - 0.13 12.6 0.1 9.2 6.7 0.0 3.1 1 1 0 2 2 2 0 SlyX Hemerythrin PF01814.18 ERZ96444.1 - 0.24 11.5 3.2 0.52 10.4 2.2 1.7 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain DUF4180 PF13788.1 ERZ96444.1 - 2 8.0 4.1 60 3.3 0.1 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4180) HSP20 PF00011.16 ERZ96446.1 - 5e-06 26.3 0.0 9.8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Mob1_phocein PF03637.12 ERZ96451.1 - 0.0056 16.3 0.0 0.0096 15.6 0.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family DUF4367 PF14285.1 ERZ96455.1 - 0.007 15.6 0.8 0.011 15.0 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) DUF4367 PF14285.1 ERZ96456.1 - 0.00095 18.5 2.8 0.0017 17.7 2.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) F-box-like_2 PF13013.1 ERZ96456.1 - 0.099 12.3 0.3 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 F-box-like domain NAD_binding_6 PF08030.7 ERZ96457.1 - 1.2e-28 100.0 0.0 2.6e-28 98.8 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 ERZ96457.1 - 7e-24 83.7 0.0 1.5e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 ERZ96457.1 - 4.4e-17 62.3 11.5 9.3e-17 61.2 8.0 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 ERZ96457.1 - 4.2e-05 23.5 0.0 8.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ERZ96457.1 - 0.06 13.9 0.0 0.64 10.6 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DDE_1 PF03184.14 ERZ96461.1 - 1.1e-08 34.4 0.1 1.2e-08 34.3 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Cu_bind_like PF02298.12 ERZ96462.1 - 6.1e-05 22.7 0.2 0.00021 21.0 0.0 1.9 2 1 0 2 2 2 1 Plastocyanin-like domain Copper-bind PF00127.15 ERZ96462.1 - 0.079 13.2 0.3 0.29 11.3 0.0 1.9 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family MSP1_C PF07462.6 ERZ96462.1 - 0.1 10.9 2.3 0.12 10.7 1.6 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DDE_1 PF03184.14 ERZ96463.1 - 8.3e-57 191.8 1.2 1.8e-56 190.7 0.8 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ96463.1 - 1e-15 57.3 0.0 2.3e-15 56.1 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ96464.1 - 2.1e-16 59.7 0.1 2.2e-16 59.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ERZ96464.1 - 0.00027 20.6 0.1 0.0003 20.5 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2674 PF10879.3 ERZ96465.1 - 0.053 13.2 0.9 0.23 11.2 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2674) CPG4 PF15481.1 ERZ96465.1 - 0.46 10.8 3.2 7.2 7.0 0.0 3.3 3 1 0 3 3 3 0 Chondroitin proteoglycan 4 IncA PF04156.9 ERZ96465.1 - 1 8.9 5.6 0.25 10.8 1.1 2.0 2 0 0 2 2 2 0 IncA protein bZIP_1 PF00170.16 ERZ96465.1 - 6.3 6.8 8.8 1.3 9.0 0.9 2.9 2 1 1 3 3 3 0 bZIP transcription factor RNase_P_Rpp14 PF01900.14 ERZ96466.1 - 3.9e-29 100.6 0.1 5.4e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family DUF3760 PF12586.3 ERZ96466.1 - 0.15 11.9 0.1 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) CBM_20 PF00686.14 ERZ96467.1 - 0.00015 21.2 0.0 0.0005 19.6 0.0 1.9 1 0 0 1 1 1 1 Starch binding domain CENP-K PF11802.3 ERZ96468.1 - 2.2e-18 66.4 3.2 9.9e-18 64.3 2.2 1.8 1 1 0 1 1 1 1 Centromere-associated protein K Sigma70_ner PF04546.8 ERZ96468.1 - 0.0009 18.9 5.1 0.0011 18.6 3.5 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region YL1 PF05764.8 ERZ96468.1 - 0.0011 18.6 2.5 0.0012 18.4 1.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Tom22 PF04281.8 ERZ96468.1 - 0.012 15.1 4.0 0.014 14.9 2.7 1.1 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 RRN3 PF05327.6 ERZ96468.1 - 0.15 10.0 1.5 0.17 9.9 1.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PBP1_TM PF14812.1 ERZ96468.1 - 1.4 9.2 6.6 2.1 8.7 4.6 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Dynactin_p22 PF07426.6 ERZ96469.1 - 1.9e-09 37.0 0.7 6.3e-09 35.3 0.5 1.9 1 1 0 1 1 1 1 Dynactin subunit p22 U-box PF04564.10 ERZ96469.1 - 0.093 12.7 0.1 20 5.2 0.0 2.4 2 0 0 2 2 2 0 U-box domain RuvC PF02075.12 ERZ96469.1 - 0.1 12.4 0.1 2.8 7.7 0.0 2.8 1 1 2 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC RRM_1 PF00076.17 ERZ96470.1 - 3.2e-16 58.7 0.0 5.6e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ96470.1 - 1.5e-15 56.9 0.0 2.8e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ96470.1 - 5.4e-08 32.5 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HAP1_N PF04849.8 ERZ96470.1 - 0.087 11.7 9.3 0.13 11.1 6.4 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ALS2CR8 PF15299.1 ERZ96470.1 - 0.1 12.1 0.7 0.14 11.6 0.5 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 TEX15 PF15326.1 ERZ96470.1 - 0.15 11.6 2.4 0.19 11.3 1.7 1.1 1 0 0 1 1 1 0 Testis expressed sequence 15 bZIP_2 PF07716.10 ERZ96470.1 - 0.19 11.5 7.0 0.36 10.7 4.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Lge1 PF11488.3 ERZ96470.1 - 0.23 11.6 3.1 0.73 10.0 2.2 1.8 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 V_ATPase_I PF01496.14 ERZ96470.1 - 0.32 8.7 2.6 0.37 8.5 1.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Packaging_FI PF14000.1 ERZ96470.1 - 0.37 10.9 9.1 0.06 13.5 3.2 1.9 1 1 1 2 2 2 0 DNA packaging protein FI UPF0242 PF06785.6 ERZ96470.1 - 0.46 9.1 4.1 0.61 8.7 2.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) IncA PF04156.9 ERZ96470.1 - 0.5 9.9 5.8 0.7 9.4 4.0 1.1 1 0 0 1 1 1 0 IncA protein DUF4140 PF13600.1 ERZ96470.1 - 0.61 10.5 5.0 1.1 9.7 3.5 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF972 PF06156.8 ERZ96470.1 - 1.2 9.4 6.7 2 8.7 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DivIC PF04977.10 ERZ96470.1 - 1.4 8.4 6.5 2.5 7.6 4.5 1.3 1 0 0 1 1 1 0 Septum formation initiator Selenoprotein_S PF06936.6 ERZ96470.1 - 8.5 5.8 9.5 8.4 5.8 3.1 2.1 2 0 0 2 2 2 0 Selenoprotein S (SelS) DUF576 PF04507.7 ERZ96471.1 - 0.0019 17.1 0.2 0.0025 16.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF576 Romo1 PF10247.4 ERZ96472.1 - 6.6e-24 83.8 5.2 8.4e-24 83.5 3.6 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Mito_carr PF00153.22 ERZ96473.1 - 2.7e-63 209.7 0.3 2.6e-21 75.1 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein CTP_transf_2 PF01467.21 ERZ96474.1 - 3.4e-24 85.6 0.0 4.7e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase tRNA_NucTran2_2 PF13735.1 ERZ96474.1 - 0.021 14.6 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative NUDIX PF00293.23 ERZ96476.1 - 2.2e-18 66.1 0.0 2.7e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Vps53_N PF04100.7 ERZ96477.1 - 3.9e-12 45.6 0.6 5.1e-12 45.2 0.4 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2450 PF10475.4 ERZ96477.1 - 0.00071 18.5 0.7 0.001 18.0 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) HrpB7 PF09486.5 ERZ96477.1 - 0.0027 17.6 0.1 0.0029 17.5 0.1 1.1 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) BLOC1_2 PF10046.4 ERZ96477.1 - 0.0078 16.3 2.3 0.019 15.1 1.6 1.7 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Vps51 PF08700.6 ERZ96477.1 - 0.0084 15.9 2.6 0.0084 15.9 0.1 2.2 2 1 1 3 3 3 1 Vps51/Vps67 IncA PF04156.9 ERZ96477.1 - 0.011 15.3 2.5 0.011 15.3 1.7 1.6 2 0 0 2 2 2 0 IncA protein COG5 PF10392.4 ERZ96477.1 - 0.028 14.3 0.1 0.06 13.2 0.0 1.6 1 1 0 1 1 1 0 Golgi transport complex subunit 5 RE_AlwI PF09491.5 ERZ96477.1 - 0.037 12.5 4.7 0.041 12.3 3.2 1.0 1 0 0 1 1 1 0 AlwI restriction endonuclease MerR-DNA-bind PF09278.6 ERZ96477.1 - 0.042 14.2 0.6 0.07 13.5 0.4 1.4 1 0 0 1 1 1 0 MerR, DNA binding ArsA_ATPase PF02374.10 ERZ96477.1 - 0.072 12.1 0.3 0.086 11.8 0.2 1.1 1 0 0 1 1 1 0 Anion-transporting ATPase Med9 PF07544.8 ERZ96477.1 - 0.099 12.3 5.4 0.18 11.5 0.8 2.4 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.10 ERZ96477.1 - 0.11 11.9 1.7 0.26 10.7 1.2 1.6 1 0 0 1 1 1 0 Septum formation initiator Spc7 PF08317.6 ERZ96477.1 - 0.15 10.6 6.2 0.18 10.4 4.3 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_TATA_bd PF12325.3 ERZ96477.1 - 0.2 11.3 5.3 0.15 11.7 2.4 1.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.14 ERZ96477.1 - 0.26 9.0 2.6 0.26 9.0 1.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ran-binding PF05508.6 ERZ96477.1 - 0.32 9.8 4.0 2.4 6.9 0.1 2.0 1 1 1 2 2 2 0 RanGTP-binding protein DUF948 PF06103.6 ERZ96477.1 - 0.33 10.8 1.2 0.73 9.7 0.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.2 ERZ96477.1 - 0.39 10.5 7.5 0.066 13.0 2.2 1.8 1 1 0 1 1 1 0 Tropomyosin like Lge1 PF11488.3 ERZ96477.1 - 0.47 10.6 3.0 0.71 10.1 2.1 1.7 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 Fzo_mitofusin PF04799.8 ERZ96477.1 - 0.54 9.6 2.5 0.55 9.6 1.0 1.5 1 1 1 2 2 2 0 fzo-like conserved region IFP_35_N PF07334.8 ERZ96477.1 - 0.97 9.4 5.1 0.47 10.4 1.8 1.7 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4404 PF14357.1 ERZ96477.1 - 2.9 8.3 5.9 4.5 7.7 1.5 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) DHquinase_I PF01487.10 ERZ96478.1 - 1.4e-61 208.0 0.0 2.1e-61 207.4 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.17 ERZ96478.1 - 4.8e-38 130.4 0.0 1.5e-37 128.9 0.0 1.8 2 0 0 2 2 1 1 Shikimate kinase Shikimate_dh_N PF08501.6 ERZ96478.1 - 5e-25 87.3 0.1 2.2e-24 85.3 0.0 2.2 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain EPSP_synthase PF00275.15 ERZ96478.1 - 7.1e-18 64.2 0.0 1.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Shikimate_DH PF01488.15 ERZ96478.1 - 1.4e-12 47.8 0.0 3.7e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_17 PF13207.1 ERZ96478.1 - 2e-07 31.8 0.0 4.8e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ERZ96478.1 - 1.8e-05 25.0 0.4 7.1e-05 23.1 0.0 2.3 4 0 0 4 4 2 1 AAA domain AAA_16 PF13191.1 ERZ96478.1 - 0.0009 19.2 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 ERZ96478.1 - 0.0027 17.9 0.0 0.0054 16.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ERZ96478.1 - 0.0038 17.0 0.0 0.0072 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ERZ96478.1 - 0.0084 16.2 0.0 0.05 13.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ96478.1 - 0.014 15.2 0.0 0.051 13.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.17 ERZ96478.1 - 0.079 11.8 0.0 0.16 10.7 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain MobB PF03205.9 ERZ96478.1 - 0.095 12.4 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 ERZ96478.1 - 0.098 12.3 0.0 0.28 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) HTH_Tnp_Tc3_2 PF01498.13 ERZ96480.1 - 1.1e-09 38.1 2.1 1.1e-09 38.1 1.5 1.8 2 0 0 2 2 2 1 Transposase DDE_3 PF13358.1 ERZ96480.1 - 2.8e-06 27.1 0.4 1.4e-05 24.8 0.3 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_DeoR PF08220.7 ERZ96480.1 - 0.0027 17.1 0.3 0.011 15.2 0.2 1.9 1 1 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_12 PF08461.5 ERZ96480.1 - 0.013 15.1 0.1 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_11 PF08279.7 ERZ96480.1 - 0.23 11.1 1.3 1.3 8.7 0.9 2.0 1 1 0 1 1 1 0 HTH domain Corona_6B_7B PF03262.8 ERZ96481.1 - 0.081 12.1 0.3 0.082 12.1 0.2 1.0 1 0 0 1 1 1 0 Coronavirus 6B/7B protein DMP1 PF07263.6 ERZ96487.1 - 0.033 12.9 0.0 0.039 12.6 0.0 1.0 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) adh_short PF00106.20 ERZ96488.1 - 7.2e-05 22.7 0.0 7.9e-05 22.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ERZ96488.1 - 0.0018 17.9 0.0 0.002 17.8 0.0 1.0 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ERZ96488.1 - 0.016 14.1 0.0 0.017 14.0 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HSDR_N PF04313.9 ERZ96489.1 - 0.015 15.0 0.1 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) TetR PF13972.1 ERZ96489.1 - 0.02 14.3 0.0 0.098 12.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional repressor GatB_Yqey PF02637.13 ERZ96489.1 - 0.055 13.1 0.6 0.51 10.0 0.0 2.1 2 0 0 2 2 2 0 GatB domain GA PF01468.12 ERZ96492.1 - 3.3 7.9 8.2 0.44 10.7 1.3 2.6 2 1 1 3 3 3 0 GA module F-box-like PF12937.2 ERZ96493.1 - 0.00022 20.8 1.1 0.00067 19.3 0.8 1.8 1 0 0 1 1 1 1 F-box-like A2L_zn_ribbon PF08792.5 ERZ96494.1 - 0.052 13.0 0.1 0.052 13.0 0.1 3.1 2 1 1 3 3 3 0 A2L zinc ribbon domain zf-CXXC PF02008.15 ERZ96494.1 - 0.53 10.1 5.2 0.38 10.5 1.0 2.0 2 0 0 2 2 2 0 CXXC zinc finger domain zf-P11 PF03854.9 ERZ96494.1 - 1.1 8.7 11.2 6.5 6.3 2.3 2.9 1 1 1 2 2 2 0 P-11 zinc finger F-box-like PF12937.2 ERZ96495.1 - 1.7e-05 24.4 0.2 5.2e-05 22.8 0.2 1.9 1 0 0 1 1 1 1 F-box-like DUF4070 PF13282.1 ERZ96495.1 - 0.074 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) LRR_6 PF13516.1 ERZ96495.1 - 0.62 10.3 7.3 0.45 10.7 0.2 4.2 5 0 0 5 5 5 0 Leucine Rich repeat MAPEG PF01124.13 ERZ96496.1 - 1.1e-16 60.5 0.7 1.4e-16 60.3 0.5 1.1 1 0 0 1 1 1 1 MAPEG family 7TMR-DISM_7TM PF07695.6 ERZ96496.1 - 0.0089 15.7 3.2 0.0089 15.7 2.2 1.9 2 0 0 2 2 2 1 7TM diverse intracellular signalling DUF202 PF02656.10 ERZ96496.1 - 0.77 10.0 6.6 4.3 7.6 2.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF202) VWA_2 PF13519.1 ERZ96497.1 - 0.0014 18.8 0.2 0.062 13.4 0.1 2.4 1 1 1 2 2 2 1 von Willebrand factor type A domain Phasin PF05597.6 ERZ96497.1 - 0.023 14.4 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) YvrJ PF12841.2 ERZ96497.1 - 0.047 12.9 0.4 0.87 8.9 0.1 2.4 2 0 0 2 2 2 0 YvrJ protein family FlxA PF14282.1 ERZ96497.1 - 0.061 13.2 2.3 0.085 12.8 0.1 2.0 2 0 0 2 2 2 0 FlxA-like protein Fzo_mitofusin PF04799.8 ERZ96497.1 - 0.11 11.8 0.5 0.26 10.6 0.0 1.8 2 0 0 2 2 2 0 fzo-like conserved region SlyX PF04102.7 ERZ96497.1 - 0.11 12.8 2.7 4.2 7.8 0.1 2.4 2 0 0 2 2 2 0 SlyX PEP-utilisers_N PF05524.8 ERZ96497.1 - 0.19 11.5 0.4 1.2 8.9 0.1 2.1 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF2802 PF10975.3 ERZ96497.1 - 0.2 11.4 1.8 0.29 10.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) HALZ PF02183.13 ERZ96497.1 - 0.21 11.3 1.0 17 5.1 0.2 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper MbeD_MobD PF04899.7 ERZ96497.1 - 0.41 10.5 3.0 0.49 10.3 0.2 2.3 2 0 0 2 2 2 0 MbeD/MobD like RVP_2 PF08284.6 ERZ96498.1 - 8.7e-09 35.4 0.1 1.6e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.18 ERZ96498.1 - 9.1e-07 28.5 0.5 1.4e-06 27.9 0.3 1.3 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.1 ERZ96498.1 - 8.7e-06 26.1 0.0 1.8e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ERZ96498.1 - 0.00012 21.8 0.0 0.00023 20.9 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 ERZ96498.1 - 0.00095 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2B PF12384.3 ERZ96498.1 - 0.0053 16.1 0.1 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Ty3 transposon peptidase Pkinase_Tyr PF07714.12 ERZ96499.1 - 0.00028 20.0 0.0 0.00045 19.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cytotoxic PF09000.5 ERZ96502.1 - 7.9e-20 70.6 0.1 1.1e-19 70.2 0.1 1.2 1 0 0 1 1 1 1 Cytotoxic LRR_1 PF00560.28 ERZ96504.1 - 3.2e-12 44.6 7.9 0.37 11.0 0.1 6.2 6 0 0 6 6 6 4 Leucine Rich Repeat LRR_8 PF13855.1 ERZ96504.1 - 1.6e-11 43.8 22.5 2.1e-06 27.4 2.2 3.5 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 ERZ96504.1 - 4.4e-10 38.9 20.8 0.0017 17.9 0.2 4.3 2 2 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ96504.1 - 2.8e-08 32.9 16.8 0.32 11.1 0.0 6.3 6 1 0 6 6 6 4 Leucine Rich repeat LRR_7 PF13504.1 ERZ96504.1 - 2e-07 30.0 13.8 0.66 10.4 0.0 5.6 6 0 0 6 6 6 4 Leucine rich repeat DUF2479 PF10651.4 ERZ96506.1 - 0.03 13.8 0.1 0.032 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2479) p450 PF00067.17 ERZ96507.1 - 5.4e-82 275.7 0.1 6.9e-82 275.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 6PF2K PF01591.13 ERZ96509.1 - 1.5e-83 279.2 0.4 1.8e-83 278.9 0.3 1.0 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 ERZ96509.1 - 1.7e-16 60.7 0.0 9.6e-16 58.2 0.0 2.0 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 ERZ96509.1 - 4.9e-10 39.4 0.0 8.9e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ERZ96509.1 - 0.00059 20.6 0.0 0.0017 19.1 0.0 1.9 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.5 ERZ96509.1 - 0.0011 18.2 0.1 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA PF00004.24 ERZ96509.1 - 0.021 15.0 0.0 0.34 11.0 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3457 PF11939.3 ERZ96509.1 - 0.03 13.8 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3457) His_Phos_2 PF00328.17 ERZ96509.1 - 0.055 12.8 0.0 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) Rad52_Rad22 PF04098.10 ERZ96509.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Rad52/22 family double-strand break repair protein GDA1_CD39 PF01150.12 ERZ96510.1 - 5.8e-103 344.6 0.0 8.2e-103 344.2 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family EcoEI_R_C PF08463.5 ERZ96511.1 - 0.0099 15.7 0.2 0.018 14.8 0.0 1.6 2 0 0 2 2 2 1 EcoEI R protein C-terminal adh_short PF00106.20 ERZ96512.1 - 6.3e-15 55.4 0.0 9.9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ERZ96512.1 - 2.6e-10 40.4 0.3 3.4e-10 40.0 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ERZ96512.1 - 4.6e-05 23.1 0.0 0.00015 21.4 0.0 1.8 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.14 ERZ96512.1 - 0.0008 18.5 0.1 0.0015 17.6 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.5 ERZ96512.1 - 0.00091 18.4 1.2 0.0013 17.9 0.8 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 ERZ96512.1 - 0.029 14.1 0.1 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.15 ERZ96512.1 - 0.036 14.1 0.1 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.10 ERZ96512.1 - 0.066 12.1 0.1 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Saccharop_dh PF03435.13 ERZ96512.1 - 0.082 11.8 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase DUF2758 PF10957.3 ERZ96512.1 - 0.092 12.5 0.6 0.2 11.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2758) 3HCDH_N PF02737.13 ERZ96512.1 - 0.094 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DIOX_N PF14226.1 ERZ96513.1 - 2.9e-34 118.0 0.0 4.1e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ERZ96513.1 - 8.7e-14 51.6 0.0 1.5e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydro_lipase PF04083.11 ERZ96513.1 - 0.075 12.3 0.0 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DUF608 PF04685.8 ERZ96513.1 - 0.13 10.9 0.0 0.59 8.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF608 F-box-like PF12937.2 ERZ96514.1 - 3e-05 23.6 2.5 3.1e-05 23.6 0.4 2.1 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 ERZ96514.1 - 0.46 10.2 12.1 1.4 8.7 0.1 5.1 5 1 1 6 6 6 0 Leucine rich repeat RICTOR_N PF14664.1 ERZ96515.1 - 7.5e-112 373.5 0.0 1.5e-111 372.5 0.0 1.5 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 ERZ96515.1 - 1.2e-80 269.7 4.6 3.8e-78 261.6 0.2 5.3 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.1 ERZ96515.1 - 8.8e-38 128.7 4.4 1.4e-36 124.9 0.3 4.0 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.1 ERZ96515.1 - 5.2e-30 103.1 1.2 3.5e-27 94.1 0.3 4.8 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.1 ERZ96515.1 - 9.5e-13 48.2 1.5 0.0018 18.5 0.1 5.5 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.17 ERZ96515.1 - 0.00036 20.3 0.7 1.3e+02 3.0 0.0 6.5 6 0 0 6 6 6 0 HEAT repeat Arm PF00514.18 ERZ96515.1 - 0.00081 19.1 1.9 23 4.9 0.0 5.6 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat LCAT PF02450.10 ERZ96516.1 - 9e-89 298.1 0.0 2.3e-88 296.8 0.0 1.6 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.2 ERZ96516.1 - 0.00026 20.7 0.0 0.00054 19.7 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ERZ96516.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_2 PF01674.13 ERZ96516.1 - 0.061 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) Nucleoplasmin PF03066.10 ERZ96516.1 - 0.15 11.5 2.1 0.25 10.8 1.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin PGAP1 PF07819.8 ERZ96516.1 - 0.17 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein NOA36 PF06524.7 ERZ96516.1 - 0.55 9.4 2.9 0.87 8.7 2.0 1.2 1 0 0 1 1 1 0 NOA36 protein HMG_box PF00505.14 ERZ96517.1 - 8e-06 26.0 0.1 4.5e-05 23.6 0.1 2.1 1 1 0 1 1 1 1 HMG (high mobility group) box DivIC PF04977.10 ERZ96519.1 - 0.0003 20.1 5.1 0.0079 15.6 0.7 2.0 1 1 1 2 2 2 2 Septum formation initiator bZIP_1 PF00170.16 ERZ96519.1 - 0.00071 19.4 6.5 0.1 12.5 0.3 2.0 1 1 1 2 2 2 2 bZIP transcription factor TMF_DNA_bd PF12329.3 ERZ96519.1 - 0.0033 17.2 5.7 0.0055 16.4 3.9 1.4 1 1 0 1 1 1 1 TATA element modulatory factor 1 DNA binding CCDC155 PF14662.1 ERZ96519.1 - 0.0041 16.7 2.7 0.11 12.0 0.5 1.9 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 DUF2216 PF10226.4 ERZ96519.1 - 0.0049 16.3 0.4 0.0053 16.2 0.3 1.3 1 0 0 1 1 1 1 Uncharacterized conserved proteins (DUF2216) Seryl_tRNA_N PF02403.17 ERZ96519.1 - 0.0075 16.2 4.8 0.0081 16.1 3.3 1.0 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.7 ERZ96519.1 - 0.0085 15.8 1.6 0.0095 15.6 1.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) TMF_TATA_bd PF12325.3 ERZ96519.1 - 0.012 15.3 1.8 0.016 14.9 1.2 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 ERZ96519.1 - 0.022 14.5 6.2 0.85 9.4 0.8 2.7 1 1 1 2 2 2 0 Basic region leucine zipper Shugoshin_N PF07558.6 ERZ96519.1 - 0.022 14.4 2.7 1.7 8.3 0.3 2.6 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region IncA PF04156.9 ERZ96519.1 - 0.028 13.9 3.7 0.034 13.7 2.6 1.1 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.6 ERZ96519.1 - 0.029 13.0 3.1 0.032 12.8 2.1 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4201 PF13870.1 ERZ96519.1 - 0.031 13.7 2.5 0.031 13.6 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) HALZ PF02183.13 ERZ96519.1 - 0.038 13.6 8.1 0.71 9.6 1.2 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF904 PF06005.7 ERZ96519.1 - 0.055 13.7 5.8 0.13 12.5 4.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF4200 PF13863.1 ERZ96519.1 - 0.057 13.3 3.5 0.09 12.7 2.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) SAB PF04382.8 ERZ96519.1 - 0.065 12.9 0.8 0.12 12.1 0.5 1.6 1 1 0 1 1 1 0 SAB domain PEARLI-4 PF05278.7 ERZ96519.1 - 0.074 12.4 2.4 0.078 12.3 1.6 1.0 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF972 PF06156.8 ERZ96519.1 - 0.096 13.0 1.7 0.31 11.4 1.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Halo_GVPC PF05465.8 ERZ96519.1 - 0.099 12.5 1.4 4.1 7.4 0.0 2.8 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat Striatin PF08232.7 ERZ96519.1 - 0.1 12.9 5.0 0.17 12.1 0.5 2.0 1 1 1 2 2 2 0 Striatin family ADIP PF11559.3 ERZ96519.1 - 0.1 12.4 1.2 0.11 12.4 0.8 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Uso1_p115_C PF04871.8 ERZ96519.1 - 0.1 12.4 2.2 0.12 12.2 1.5 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region NYD-SP28_assoc PF14775.1 ERZ96519.1 - 0.14 11.9 1.7 0.43 10.2 0.3 2.2 2 1 1 3 3 3 0 Sperm tail C-terminal domain Laminin_II PF06009.7 ERZ96519.1 - 0.17 11.6 2.2 0.19 11.4 1.5 1.0 1 0 0 1 1 1 0 Laminin Domain II CCDC92 PF14916.1 ERZ96519.1 - 0.17 11.4 1.0 1.2 8.7 0.2 2.4 1 1 1 2 2 2 0 Coiled-coil domain of unknown function DUF4140 PF13600.1 ERZ96519.1 - 0.34 11.3 2.4 0.56 10.6 1.7 1.5 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TPR_MLP1_2 PF07926.7 ERZ96519.1 - 0.44 10.2 4.0 0.66 9.7 2.8 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein IFP_35_N PF07334.8 ERZ96519.1 - 0.49 10.4 4.6 1.5 8.8 1.6 2.0 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus WD40_alt PF14077.1 ERZ96519.1 - 1.1 8.9 3.4 2 8.1 0.3 2.3 1 1 2 3 3 3 0 Alternative WD40 repeat motif DUF465 PF04325.8 ERZ96519.1 - 5.3 6.8 6.8 7.9 6.2 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF465) Sel1 PF08238.7 ERZ96520.1 - 2.6e-31 107.3 11.9 1.7e-11 44.3 0.3 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ERZ96520.1 - 0.0048 16.5 3.3 0.0048 16.5 2.3 3.2 1 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.1 ERZ96520.1 - 0.0048 17.5 1.9 0.18 12.5 0.6 2.5 2 1 1 3 3 2 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ERZ96520.1 - 0.006 16.5 0.2 0.45 10.5 0.1 2.2 1 1 1 2 2 2 1 Influenza Matrix protein (M1) C-terminal domain TPR_7 PF13176.1 ERZ96520.1 - 0.0096 15.6 3.6 0.47 10.3 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat HTH_7 PF02796.10 ERZ96520.1 - 0.017 14.9 1.9 6.1 6.7 0.1 3.3 1 1 1 3 3 3 0 Helix-turn-helix domain of resolvase MIT PF04212.13 ERZ96520.1 - 0.022 14.6 9.2 1.4 8.8 0.1 3.4 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 ERZ96520.1 - 0.047 13.4 11.0 1.1 9.1 0.4 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2235 PF09994.4 ERZ96520.1 - 0.17 11.2 1.3 0.2 10.9 0.9 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_12 PF13424.1 ERZ96520.1 - 0.24 11.3 11.3 0.89 9.5 2.4 3.8 1 1 2 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 ERZ96520.1 - 0.26 11.9 10.6 9.7 7.2 0.2 4.4 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat SNAP PF14938.1 ERZ96520.1 - 0.33 10.0 6.7 0.24 10.5 1.8 2.5 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 ERZ96520.1 - 0.47 11.0 12.0 0.61 10.6 0.1 4.5 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ96520.1 - 0.8 9.7 0.1 0.8 9.7 0.1 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ96520.1 - 2.7 8.3 5.2 23 5.4 0.4 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ERZ96521.1 - 1.4e-268 861.4 130.3 6.4e-13 48.8 1.0 23.5 24 0 0 24 24 24 23 Sel1 repeat TPR_11 PF13414.1 ERZ96521.1 - 9.3e-33 111.7 161.4 1.4e-05 24.6 1.7 16.9 1 1 15 18 18 18 17 TPR repeat TPR_16 PF13432.1 ERZ96521.1 - 2.9e-24 85.1 55.1 0.00027 21.4 0.2 14.1 7 3 8 16 16 16 10 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ96521.1 - 9.5e-23 78.1 68.1 0.71 9.8 0.0 20.3 17 4 4 21 21 21 9 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ96521.1 - 3.1e-19 68.0 99.3 0.11 12.9 0.1 21.9 23 0 0 23 23 23 8 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ96521.1 - 6.5e-17 60.0 137.5 0.43 10.6 0.1 27.4 29 3 0 29 29 23 11 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ96521.1 - 2.7e-12 46.4 114.2 0.02 14.7 2.3 17.8 1 1 20 22 22 22 17 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ96521.1 - 2.2e-10 40.2 31.9 12 6.9 0.0 16.6 6 5 12 18 18 18 0 Tetratricopeptide repeat Apc3 PF12895.2 ERZ96521.1 - 2.9e-08 33.7 102.7 0.027 14.6 1.9 14.2 6 4 8 14 14 14 10 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.13 ERZ96521.1 - 1.4e-06 28.0 125.6 0.4 10.5 0.2 21.6 12 5 8 22 22 22 7 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.4 ERZ96521.1 - 6.6e-06 25.2 14.4 30 3.9 0.0 12.4 17 0 0 17 17 17 0 SHNi-TPR SLBB PF10531.4 ERZ96521.1 - 7e-06 25.8 18.6 65 3.5 0.0 13.3 17 0 0 17 17 15 0 SLBB domain Aurora-A_bind PF09041.5 ERZ96521.1 - 7.9e-05 22.3 21.3 1.9 8.3 0.0 11.0 6 5 8 14 14 14 2 Aurora-A binding TPR_3 PF07720.7 ERZ96521.1 - 0.003 17.3 66.2 2.5 7.9 0.3 15.0 15 0 0 15 15 14 3 Tetratricopeptide repeat DUF2442 PF10387.4 ERZ96521.1 - 0.064 13.2 0.3 60 3.7 0.0 6.0 9 0 0 9 9 8 0 Protein of unknown function (DUF2442) DUF725 PF05267.7 ERZ96521.1 - 0.081 12.8 4.6 0.6 10.0 1.1 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF725) TPR_19 PF14559.1 ERZ96521.1 - 2.8 8.3 89.8 6 7.2 0.7 18.0 12 6 9 21 21 21 0 Tetratricopeptide repeat DUF2235 PF09994.4 ERZ96522.1 - 4.1e-61 206.7 0.0 5.2e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ERZ96522.1 - 0.042 13.6 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family TLD PF07534.11 ERZ96523.1 - 7.6e-15 55.1 1.6 7.6e-15 55.1 1.1 1.9 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ96523.1 - 3.3e-06 26.8 0.3 1.3e-05 24.9 0.1 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch PAE PF03283.8 ERZ96523.1 - 0.58 8.7 3.7 0.16 10.6 0.5 1.4 2 0 0 2 2 2 0 Pectinacetylesterase G3P_acyltransf PF02660.10 ERZ96524.1 - 0.11 12.0 1.4 0.12 11.9 1.0 1.0 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase Dimer_Tnp_hAT PF05699.9 ERZ96525.1 - 7.7e-13 47.8 0.2 8.5e-13 47.7 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3867 PF12983.2 ERZ96527.1 - 0.0051 16.8 3.8 0.0055 16.6 2.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3867) PhoU PF01895.14 ERZ96527.1 - 0.014 15.7 1.3 0.019 15.4 0.6 1.4 1 1 0 1 1 1 0 PhoU domain Apolipoprotein PF01442.13 ERZ96527.1 - 0.044 13.2 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2841 PF11001.3 ERZ96527.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2841) RRF PF01765.14 ERZ96527.1 - 0.18 11.2 4.2 0.89 9.0 1.6 2.0 2 0 0 2 2 2 0 Ribosome recycling factor AKAP95 PF04988.7 ERZ96527.1 - 0.18 11.5 2.2 0.26 11.0 1.2 1.5 1 1 1 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) PfUIS3 PF11567.3 ERZ96527.1 - 0.2 11.8 3.9 0.59 10.3 0.3 2.1 1 1 1 2 2 2 0 Plasmodium falciparum UIS3 membrane protein Dynamin_N PF00350.18 ERZ96527.1 - 0.2 11.4 1.1 0.29 10.9 0.8 1.5 1 1 0 1 1 1 0 Dynamin family SecA_DEAD PF07517.9 ERZ96527.1 - 0.25 10.5 1.7 0.36 10.0 0.7 1.6 1 1 0 2 2 2 0 SecA DEAD-like domain AAA_23 PF13476.1 ERZ96527.1 - 0.38 11.0 9.0 0.48 10.7 6.2 1.1 1 0 0 1 1 1 0 AAA domain DUF3782 PF12644.2 ERZ96527.1 - 0.96 9.2 3.4 2.4 8.0 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3782) BTB PF00651.26 ERZ96528.1 - 5.8e-18 64.9 0.6 1.4e-17 63.7 0.4 1.6 1 0 0 1 1 1 1 BTB/POZ domain ADK_lid PF05191.9 ERZ96528.1 - 0.069 12.8 0.8 0.15 11.7 0.5 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid ACOX PF01756.14 ERZ96529.1 - 1.1e-33 116.1 0.0 1.8e-33 115.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 ERZ96529.1 - 2.8e-11 42.7 0.5 6.1e-11 41.6 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 ERZ96529.1 - 7.8e-07 29.4 0.1 1.5e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 ERZ96529.1 - 0.051 13.6 0.0 0.15 12.1 0.0 1.8 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Adaptin_N PF01602.15 ERZ96530.1 - 3.4e-71 240.1 12.3 4.7e-71 239.7 8.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP4E_app_platf PF14807.1 ERZ96530.1 - 2.6e-08 34.0 0.7 0.0033 17.6 0.0 3.0 1 1 1 2 2 2 2 Adaptin AP4 complex epsilon appendage platform HEAT_2 PF13646.1 ERZ96530.1 - 0.00032 20.9 0.0 0.19 12.0 0.0 3.9 3 1 0 3 3 3 1 HEAT repeats HIT PF01230.18 ERZ96531.1 - 1.3e-19 70.5 0.0 2.2e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ERZ96531.1 - 0.00029 21.0 0.0 0.00043 20.4 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 ERZ96531.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 F-box-like_2 PF13013.1 ERZ96532.1 - 0.023 14.4 0.1 0.037 13.7 0.1 1.3 1 0 0 1 1 1 0 F-box-like domain FANCI_S1 PF14675.1 ERZ96532.1 - 0.024 13.9 0.1 0.027 13.8 0.1 1.1 1 0 0 1 1 1 0 FANCI solenoid 1 F-box PF00646.28 ERZ96532.1 - 0.063 12.9 0.0 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 F-box domain YfhO PF09586.5 ERZ96533.1 - 8.7 4.2 11.8 14 3.5 8.2 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SPRY PF00622.23 ERZ96534.1 - 3.1e-09 36.9 0.1 5.9e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ96534.1 - 7e-06 26.0 0.4 7e-06 26.0 0.3 2.2 3 0 0 3 3 3 1 BTB/POZ domain DUF3342 PF11822.3 ERZ96534.1 - 0.084 11.9 0.1 0.27 10.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) DUF977 PF06163.6 ERZ96534.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) DUF4050 PF13259.1 ERZ96535.1 - 0.54 10.1 3.3 0.93 9.4 2.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) Apolipoprotein PF01442.13 ERZ96536.1 - 0.13 11.7 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Tropomodulin PF03250.9 ERZ96537.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Tropomodulin LuxC PF05893.9 ERZ96537.1 - 0.07 11.8 0.0 0.08 11.6 0.0 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF911 PF06023.7 ERZ96537.1 - 0.07 12.3 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 Archaeal protein of unknown function (DUF911) Pkinase PF00069.20 ERZ96538.1 - 0.036 13.2 0.1 0.097 11.8 0.0 1.8 1 1 1 2 2 2 0 Protein kinase domain DNA_primase_lrg PF04104.9 ERZ96541.1 - 0.021 14.0 0.0 0.027 13.7 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Arylesterase PF01731.15 ERZ96541.1 - 0.072 13.0 0.4 0.097 12.6 0.3 1.2 1 0 0 1 1 1 0 Arylesterase Chorismate_bind PF00425.13 ERZ96542.1 - 1.7e-94 315.9 0.0 4.4e-94 314.6 0.0 1.6 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 ERZ96542.1 - 1.7e-29 102.6 0.0 6.2e-27 94.3 0.0 2.9 3 0 0 3 3 3 2 Anthranilate synthase component I, N terminal region Methyltransf_11 PF08241.7 ERZ96545.1 - 9.1e-14 51.7 0.0 1.5e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ96545.1 - 1.3e-12 47.7 0.0 1.7e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ96545.1 - 3.9e-12 45.9 0.0 7.9e-12 45.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ96545.1 - 3.1e-09 37.0 0.0 1.1e-08 35.3 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ96545.1 - 3.9e-08 33.6 0.0 7.3e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ96545.1 - 2e-07 31.5 0.0 9.9e-07 29.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ96545.1 - 6e-07 28.8 0.0 2.3e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.11 ERZ96545.1 - 1e-05 24.1 0.0 2.1e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.10 ERZ96545.1 - 3e-05 23.7 0.0 5e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_4 PF02390.12 ERZ96545.1 - 5.6e-05 22.2 0.0 0.0021 17.1 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 ERZ96545.1 - 0.00023 21.1 0.0 0.00051 20.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ERZ96545.1 - 0.00069 19.0 0.0 0.0014 18.0 0.0 1.5 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.13 ERZ96545.1 - 0.0014 17.8 0.0 0.0017 17.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase CheR PF01739.13 ERZ96545.1 - 0.0014 17.9 0.0 0.0038 16.5 0.0 1.6 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.14 ERZ96545.1 - 0.0088 16.0 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.14 ERZ96545.1 - 0.099 12.1 0.0 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.6 ERZ96545.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) F-box-like PF12937.2 ERZ96546.1 - 0.00059 19.5 1.8 0.0017 18.0 0.7 2.2 2 0 0 2 2 2 1 F-box-like RNase_T PF00929.19 ERZ96547.1 - 9.3e-27 94.3 0.1 1.4e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 ERZ96547.1 - 0.00032 20.2 0.0 0.00078 18.9 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease RNase_H_2 PF13482.1 ERZ96547.1 - 0.012 15.3 0.2 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 RNase_H superfamily Profilin PF00235.14 ERZ96548.1 - 0.048 13.7 0.4 0.083 13.0 0.1 1.5 1 1 0 1 1 1 0 Profilin ATP-synt_F PF01990.12 ERZ96548.1 - 0.075 13.4 0.8 0.15 12.4 0.1 1.8 1 1 1 2 2 2 0 ATP synthase (F/14-kDa) subunit DUF4275 PF14101.1 ERZ96548.1 - 0.13 12.3 0.6 0.27 11.3 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) Dimer_Tnp_hAT PF05699.9 ERZ96549.1 - 2.3e-13 49.5 0.2 3.5e-13 48.9 0.1 1.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ERZ96549.1 - 5.3e-05 23.1 0.0 7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Aldo_ket_red PF00248.16 ERZ96550.1 - 3.1e-30 104.9 0.0 3.5e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase_Tyr PF07714.12 ERZ96551.1 - 3.7e-05 22.9 0.0 4.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96551.1 - 0.003 16.7 0.0 0.0045 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ALG3 PF05208.8 ERZ96552.1 - 9e-141 469.3 28.5 1.3e-140 468.8 19.8 1.2 1 0 0 1 1 1 1 ALG3 protein DUF2009 PF09418.5 ERZ96553.1 - 1.6e-106 356.8 2.8 2.1e-106 356.4 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.19 ERZ96553.1 - 2.1e-05 24.3 6.3 4.2e-05 23.3 4.4 1.5 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.16 ERZ96553.1 - 0.034 14.0 4.2 0.086 12.7 2.9 1.7 1 0 0 1 1 1 0 IBR domain DUF2797 PF10977.3 ERZ96553.1 - 0.14 11.7 2.6 4.7 6.7 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2797) zf-HIT PF04438.11 ERZ96553.1 - 0.49 10.0 4.2 1.1 8.9 2.9 1.6 1 0 0 1 1 1 0 HIT zinc finger TFIIS_M PF07500.9 ERZ96553.1 - 5.9 6.9 8.6 4.1 7.4 0.1 3.0 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS), central domain AAA_14 PF13173.1 ERZ96557.1 - 0.04 13.8 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ERZ96557.1 - 0.057 14.2 0.0 0.4 11.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain CBM49 PF09478.5 ERZ96557.1 - 0.44 10.6 2.2 4.2 7.5 0.3 2.5 1 1 1 2 2 2 0 Carbohydrate binding domain CBM49 Myb_DNA-binding PF00249.26 ERZ96558.1 - 1.8e-33 114.3 10.1 4.7e-08 32.9 0.1 4.1 4 0 0 4 4 4 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ96558.1 - 1.1e-30 105.5 12.5 6e-09 35.8 0.1 4.1 3 1 1 4 4 4 4 Myb-like DNA-binding domain Annexin PF00191.15 ERZ96558.1 - 0.036 13.9 0.2 2.3 8.1 0.0 2.9 3 0 0 3 3 3 0 Annexin DUF4116 PF13475.1 ERZ96558.1 - 0.059 12.8 0.6 3.7 7.0 0.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4116) Myb_DNA-bind_5 PF13873.1 ERZ96558.1 - 0.99 9.3 6.9 17 5.4 0.1 4.1 3 2 2 5 5 5 0 Myb/SANT-like DNA-binding domain Dimer_Tnp_hAT PF05699.9 ERZ96559.1 - 4e-16 58.4 0.0 4.3e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region WD40 PF00400.27 ERZ96561.1 - 2.9e-16 58.6 11.0 0.00012 21.8 0.9 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat Dynein_IC2 PF11540.3 ERZ96561.1 - 0.00045 19.5 0.1 0.001 18.3 0.1 1.5 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 Rrn6 PF10214.4 ERZ96561.1 - 0.0012 17.0 0.1 0.0012 17.0 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I-specific transcription-initiation factor Menin PF05053.8 ERZ96561.1 - 0.91 7.6 5.7 1.4 7.0 3.9 1.2 1 0 0 1 1 1 0 Menin AAA_21 PF13304.1 ERZ96564.1 - 0.05 13.5 6.2 0.068 13.1 4.3 1.2 1 0 0 1 1 1 0 AAA domain LSM PF01423.17 ERZ96565.1 - 6.2e-06 25.6 0.3 7.9e-06 25.3 0.2 1.1 1 0 0 1 1 1 1 LSM domain FA_hydroxylase PF04116.8 ERZ96566.1 - 1.6e-10 41.3 33.7 4.3e-10 39.9 19.6 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily SWIB PF02201.13 ERZ96568.1 - 6.5e-19 67.3 0.0 2e-18 65.8 0.0 1.9 1 0 0 1 1 1 1 SWIB/MDM2 domain UCH PF00443.24 ERZ96569.1 - 5.1e-47 160.2 0.4 7e-47 159.7 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ERZ96569.1 - 1.9e-13 50.2 0.5 4.3e-13 49.1 0.3 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 ERZ96569.1 - 5.1e-11 42.5 0.1 8.4e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SoxG PF04268.7 ERZ96570.1 - 0.096 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family Herpes_BTRF1 PF04682.7 ERZ96570.1 - 2.8 7.2 8.6 3.4 6.9 6.0 1.1 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region Rpn3_C PF08375.6 ERZ96571.1 - 0.19 12.1 2.3 0.21 12.0 1.6 1.1 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal F-box-like PF12937.2 ERZ96573.1 - 2.9e-05 23.7 1.0 7.1e-05 22.4 0.7 1.6 1 0 0 1 1 1 1 F-box-like DUF4116 PF13475.1 ERZ96573.1 - 0.022 14.2 2.6 0.028 13.9 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) P22_AR_C PF10548.4 ERZ96574.1 - 0.024 14.5 0.2 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 P22AR C-terminal domain RTBV_P46 PF06216.6 ERZ96574.1 - 0.38 9.5 4.4 0.4 9.4 3.0 1.0 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein TIP39 PF14980.1 ERZ96574.1 - 2.2 7.9 5.8 1.2 8.7 0.3 2.1 2 0 0 2 2 2 0 TIP39 peptide DUF4413 PF14372.1 ERZ96575.1 - 1.9e-07 31.0 0.1 2.3e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) FAR1 PF03101.10 ERZ96576.1 - 0.044 14.3 0.6 0.044 14.3 0.4 1.6 2 0 0 2 2 2 0 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ERZ96576.1 - 0.051 13.1 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 MuDR family transposase MULE PF10551.4 ERZ96577.1 - 4.7e-09 36.2 0.1 1.1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain UCH PF00443.24 ERZ96579.1 - 0.061 12.4 0.0 0.061 12.4 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Cys_rich_VLP PF14194.1 ERZ96580.1 - 0.1 12.3 0.2 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Cysteine-rich VLP SAM_1 PF00536.25 ERZ96581.1 - 1.5e-10 41.1 1.2 0.00017 21.7 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) RTC4 PF14474.1 ERZ96582.1 - 3.6e-20 72.1 0.1 4.3e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 RTC4-like domain RasGAP PF00616.14 ERZ96583.1 - 6.1e-44 150.0 0.8 6.1e-44 150.0 0.6 2.7 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 ERZ96583.1 - 2.5e-34 117.9 9.5 7.7e-34 116.4 4.7 3.1 2 1 0 2 2 2 1 RasGAP C-terminus IQ PF00612.22 ERZ96583.1 - 8e-16 56.1 8.8 0.00012 21.4 0.4 4.8 4 0 0 4 4 4 4 IQ calmodulin-binding motif CH PF00307.26 ERZ96583.1 - 6.9e-14 51.7 0.1 8.4e-13 48.3 0.0 2.9 2 0 0 2 2 2 1 Calponin homology (CH) domain Apolipoprotein PF01442.13 ERZ96585.1 - 1.9e-07 30.7 15.6 1.9e-07 30.7 10.8 2.2 2 1 0 2 2 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 ERZ96585.1 - 4.9e-05 23.1 18.1 0.00058 19.7 4.9 3.1 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.1 ERZ96585.1 - 0.0011 17.5 33.0 0.0016 16.9 22.9 1.2 1 0 0 1 1 1 1 AAA domain DUF883 PF05957.8 ERZ96585.1 - 0.006 16.9 10.4 0.0092 16.3 3.6 2.9 2 1 0 2 2 2 1 Bacterial protein of unknown function (DUF883) Phasin PF05597.6 ERZ96585.1 - 0.0095 15.7 13.2 0.0095 15.7 9.1 2.6 1 1 1 2 2 2 1 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3584 PF12128.3 ERZ96585.1 - 0.014 12.7 29.9 0.028 11.7 20.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Cytochrom_B_N_2 PF13631.1 ERZ96585.1 - 0.054 13.2 4.2 1 9.1 2.0 2.2 2 0 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB Mer2 PF09074.5 ERZ96585.1 - 0.12 12.3 36.1 0.4 10.5 17.1 3.0 1 1 1 2 2 2 0 Mer2 Prominin PF05478.6 ERZ96585.1 - 0.18 9.2 20.4 0.026 12.0 9.8 2.5 1 1 2 3 3 3 0 Prominin APP_E2 PF12925.2 ERZ96585.1 - 0.24 10.9 22.4 0.38 10.3 4.8 2.8 1 1 1 2 2 2 0 E2 domain of amyloid precursor protein Bacillus_HBL PF05791.6 ERZ96585.1 - 0.25 10.7 26.7 13 5.1 18.5 3.0 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) SDH_alpha PF03313.10 ERZ96585.1 - 0.51 9.3 1.6 1 8.3 0.6 1.8 1 1 0 1 1 1 0 Serine dehydratase alpha chain DUF1664 PF07889.7 ERZ96585.1 - 0.75 9.6 22.4 0.43 10.3 7.9 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.3 ERZ96585.1 - 1 8.3 17.8 0.13 11.3 7.6 2.3 1 1 0 2 2 2 0 Invariant surface glycoprotein DUF2317 PF10079.4 ERZ96585.1 - 1.2 7.6 25.5 0.57 8.7 10.7 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2317) Tweety PF04906.8 ERZ96585.1 - 1.2 7.4 15.0 1.1 7.5 3.0 2.5 1 1 1 2 2 2 0 Tweety Mitofilin PF09731.4 ERZ96585.1 - 1.3 7.5 40.1 0.19 10.3 17.2 2.2 1 1 1 2 2 2 0 Mitochondrial inner membrane protein Allexi_40kDa PF05549.6 ERZ96585.1 - 1.6 7.9 16.7 0.11 11.8 5.0 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein AAA_32 PF13654.1 ERZ96585.1 - 2.7 6.5 25.7 1.5 7.4 15.5 2.0 1 1 1 2 2 2 0 AAA domain KfrA_N PF11740.3 ERZ96585.1 - 2.8 8.4 8.3 6.9 7.1 3.9 2.7 1 1 2 3 3 3 0 Plasmid replication region DNA-binding N-term Peptidase_M75 PF09375.5 ERZ96585.1 - 3.4 6.9 9.2 1.1e+02 2.0 6.4 2.4 1 1 0 1 1 1 0 Imelysin WXG100 PF06013.7 ERZ96585.1 - 5.1 7.1 8.2 6 6.9 1.9 3.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Exonuc_VII_L PF02601.10 ERZ96585.1 - 6.3 5.9 32.7 0.7 9.0 13.3 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit Baculo_p24 PF05073.7 ERZ96585.1 - 9.6 5.7 26.1 0.24 10.9 7.4 3.4 2 1 1 3 3 3 0 Baculovirus P24 capsid protein F-box-like PF12937.2 ERZ96588.1 - 0.21 11.3 2.0 0.19 11.5 0.4 1.7 2 0 0 2 2 2 0 F-box-like Smg4_UPF3 PF03467.10 ERZ96589.1 - 0.05 13.5 0.5 0.055 13.4 0.3 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family DUF2457 PF10446.4 ERZ96592.1 - 0.046 12.4 7.0 0.044 12.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PRP1_N PF06424.7 ERZ96592.1 - 0.098 12.9 5.8 0.14 12.4 4.0 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF506 PF04720.7 ERZ96592.1 - 0.47 10.0 3.3 0.6 9.7 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF506) NOA36 PF06524.7 ERZ96592.1 - 5.2 6.2 8.1 7.3 5.7 5.6 1.2 1 0 0 1 1 1 0 NOA36 protein Pkinase_Tyr PF07714.12 ERZ96597.1 - 9.4e-26 90.4 0.0 1.6e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96597.1 - 2.7e-25 88.9 0.3 4.7e-25 88.2 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF2217 PF10265.4 ERZ96598.1 - 0.059 12.1 0.7 0.063 12.0 0.5 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) P_C PF06640.6 ERZ96598.1 - 0.23 11.4 4.4 0.25 11.2 3.0 1.1 1 0 0 1 1 1 0 P protein C-terminus Maf1 PF09174.5 ERZ96598.1 - 0.32 10.8 2.0 0.39 10.5 1.4 1.1 1 0 0 1 1 1 0 Maf1 regulator DUF1410 PF07198.6 ERZ96600.1 - 0.026 14.8 1.8 0.027 14.7 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1410) Pkinase PF00069.20 ERZ96603.1 - 5.7e-26 91.2 3.3 9.4e-26 90.5 2.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96603.1 - 7.7e-26 90.7 0.2 1.2e-25 90.0 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ERZ96603.1 - 0.018 14.4 0.2 0.041 13.2 0.1 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.18 ERZ96603.1 - 0.062 13.0 0.1 0.085 12.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dimer_Tnp_hAT PF05699.9 ERZ96606.1 - 2.7e-06 26.8 0.0 6.7e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ERZ96606.1 - 0.0019 17.6 0.0 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) DUF4413 PF14372.1 ERZ96606.1 - 0.0022 17.9 0.3 0.0074 16.2 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) Phage-tail_1 PF09097.5 ERZ96607.1 - 0.034 13.6 1.8 1.3 8.5 0.2 2.9 2 1 1 3 3 3 0 Baseplate structural protein, domain 1 EF-hand_2 PF09068.6 ERZ96607.1 - 0.14 12.2 1.8 0.24 11.4 0.1 2.1 2 0 0 2 2 2 0 EF hand NAD_binding_5 PF07994.7 ERZ96608.1 - 0.043 13.2 0.0 0.059 12.8 0.0 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase p450 PF00067.17 ERZ96609.1 - 7.2e-37 126.9 0.2 7.9e-37 126.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ96610.1 - 3e-40 138.1 0.1 3.4e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TerD PF02342.13 ERZ96611.1 - 1.6e-13 50.4 0.0 2.8e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ96611.1 - 3.7e-07 29.4 0.3 9.1e-07 28.1 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96611.1 - 0.0028 17.2 0.1 0.0062 16.2 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-C3HC4 PF00097.20 ERZ96611.1 - 0.083 12.5 4.9 0.21 11.2 3.4 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NMD3 PF04981.8 ERZ96611.1 - 0.16 11.0 2.0 0.26 10.3 1.4 1.3 1 0 0 1 1 1 0 NMD3 family zf-C3HC4_2 PF13923.1 ERZ96611.1 - 2.4 8.2 9.0 0.24 11.4 2.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sel1 PF08238.7 ERZ96612.1 - 3.6e-120 389.7 41.0 1.8e-11 44.2 0.0 13.3 13 0 0 13 13 13 12 Sel1 repeat TPR_17 PF13431.1 ERZ96612.1 - 0.00065 19.6 27.5 6.9 7.1 0.1 10.2 11 0 0 11 11 11 2 Tetratricopeptide repeat DUF3089 PF11288.3 ERZ96612.1 - 0.034 13.3 0.6 1.8 7.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3089) PvlArgDC PF01862.11 ERZ96612.1 - 0.1 12.1 3.1 20 4.7 0.0 5.7 9 1 1 10 10 10 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) MMtag PF10159.4 ERZ96612.1 - 0.13 12.2 34.9 0.71 9.9 0.8 7.8 2 2 7 9 9 9 0 Kinase phosphorylation protein zf-C2H2_2 PF12756.2 ERZ96613.1 - 0.072 13.2 0.3 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Yip1 PF04893.12 ERZ96613.1 - 9.9 5.6 12.5 13 5.2 8.3 1.5 1 1 0 1 1 1 0 Yip1 domain DUF2392 PF10288.4 ERZ96615.1 - 7.9 6.8 9.4 0.53 10.6 0.3 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF2392) Pkinase_Tyr PF07714.12 ERZ96617.1 - 3.2e-31 108.3 0.0 5.9e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96617.1 - 1.3e-29 103.1 0.1 2.4e-29 102.2 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ERZ96617.1 - 0.0054 15.9 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ERZ96617.1 - 0.11 12.1 0.2 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRRC37AB_C PF14914.1 ERZ96622.1 - 0.0053 16.1 2.5 0.073 12.4 0.0 2.3 2 0 0 2 2 2 1 LRRC37A/B like protein 1 C-terminal domain BAF1_ABF1 PF04684.8 ERZ96622.1 - 0.24 10.2 9.4 0.29 9.9 6.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Translin PF01997.11 ERZ96622.1 - 0.34 10.4 2.3 0.6 9.6 1.6 1.3 1 0 0 1 1 1 0 Translin family YfhO PF09586.5 ERZ96622.1 - 1.2 7.0 8.8 2.4 6.0 6.1 1.5 1 0 0 1 1 1 0 Bacterial membrane protein YfhO IncA PF04156.9 ERZ96622.1 - 1.5 8.3 10.0 3.3 7.2 6.9 1.6 1 1 0 1 1 1 0 IncA protein RSN1_TM PF13967.1 ERZ96622.1 - 3.9 6.9 5.6 2.5 7.6 0.1 2.5 3 0 0 3 3 3 0 Late exocytosis, associated with Golgi transport DUF2802 PF10975.3 ERZ96622.1 - 6.5 6.5 11.7 13 5.6 8.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) p450 PF00067.17 ERZ96623.1 - 3.3e-49 167.6 0.0 3.9e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ96624.1 - 4.4e-13 48.5 0.0 4.9e-13 48.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ96625.1 - 4e-52 177.2 0.0 4.6e-52 177.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 ERZ96626.1 - 1.1e-05 25.0 1.3 1.1e-05 25.0 0.9 2.7 3 0 0 3 3 3 1 F-box-like Exo_endo_phos_2 PF14529.1 ERZ96627.1 - 2.9e-09 36.5 0.7 6.2e-09 35.5 0.5 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ96627.1 - 1.5e-07 31.6 0.0 2e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Tubulin PF00091.20 ERZ96627.1 - 0.0027 17.5 0.2 0.005 16.6 0.1 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FlaF PF07309.6 ERZ96627.1 - 0.031 14.1 2.7 0.3 10.9 0.3 2.6 3 0 0 3 3 3 0 Flagellar protein FlaF DUF4047 PF13256.1 ERZ96627.1 - 2.2 8.2 10.4 0.12 12.3 2.5 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4047) TPR_11 PF13414.1 ERZ96628.1 - 4.6e-13 48.6 6.2 0.00016 21.2 0.2 3.6 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.1 ERZ96628.1 - 1.2e-09 38.5 0.6 0.013 16.1 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ96628.1 - 3.2e-07 29.6 6.2 0.028 14.2 0.0 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ96628.1 - 1.7e-05 24.6 5.5 0.2 11.9 0.2 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ96628.1 - 5.1e-05 22.8 10.5 1.4 8.9 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ96628.1 - 5.3e-05 22.7 7.4 2.5 8.0 0.0 5.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ96628.1 - 0.00012 21.5 7.6 0.14 11.7 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ96628.1 - 0.00042 20.6 0.1 5.6 7.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ96628.1 - 0.0009 19.1 6.2 1.2 9.1 0.3 4.7 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ96628.1 - 0.0023 18.2 0.6 3 8.2 0.1 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat Prominin PF05478.6 ERZ96628.1 - 0.016 12.7 3.8 0.029 11.9 2.7 1.3 1 0 0 1 1 1 0 Prominin TPR_6 PF13174.1 ERZ96628.1 - 1 9.9 7.1 4.2 8.0 0.0 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat HSCB_C PF07743.8 ERZ96628.1 - 8 7.0 6.8 10 6.6 0.2 4.0 4 1 0 4 4 4 0 HSCB C-terminal oligomerisation domain DUF3217 PF11506.3 ERZ96629.1 - 0.059 13.0 0.1 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) zf-MYND PF01753.13 ERZ96629.1 - 0.076 12.8 6.6 0.15 11.9 4.5 1.5 1 0 0 1 1 1 0 MYND finger Bestrophin PF01062.16 ERZ96630.1 - 1.5e-51 175.0 0.0 1.3e-50 172.0 0.0 1.9 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel MttA_Hcf106 PF02416.11 ERZ96630.1 - 0.068 12.2 0.8 0.17 11.0 0.6 1.7 1 0 0 1 1 1 0 mttA/Hcf106 family VIT1 PF01988.14 ERZ96630.1 - 0.079 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 VIT family DUF1365 PF07103.6 ERZ96633.1 - 0.035 13.1 0.1 0.045 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) INTS2 PF14750.1 ERZ96634.1 - 5.7e-89 298.9 9.3 7.2e-89 298.6 6.4 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 BTB PF00651.26 ERZ96635.1 - 1.2e-05 25.2 0.1 3.5e-05 23.7 0.0 1.9 2 1 0 2 2 2 1 BTB/POZ domain BTB PF00651.26 ERZ96636.1 - 4.4e-18 65.2 0.3 9e-18 64.2 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96636.1 - 6.4e-11 42.0 5.6 9.9e-09 34.9 0.3 4.0 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ERZ96636.1 - 4.3e-10 39.7 0.8 4.4e-09 36.4 0.2 2.6 2 0 0 2 2 2 1 TLD DUF3342 PF11822.3 ERZ96636.1 - 0.022 13.9 1.2 0.036 13.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BACK PF07707.10 ERZ96637.1 - 0.026 14.3 0.7 0.16 11.8 0.0 2.5 2 1 2 4 4 4 0 BTB And C-terminal Kelch Zds_C PF08632.5 ERZ96637.1 - 0.058 12.7 0.7 10 5.5 0.2 2.3 2 0 0 2 2 2 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term SAPS PF04499.10 ERZ96639.1 - 3.3e-32 111.7 0.0 3.3e-32 111.7 0.0 1.5 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein zf-H2C2_2 PF13465.1 ERZ96640.1 - 5.9e-08 32.6 15.8 4.6e-05 23.4 0.5 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 ERZ96640.1 - 0.0019 18.4 0.3 0.0019 18.4 0.2 3.3 3 1 1 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ96640.1 - 0.043 14.1 6.2 0.18 12.1 0.2 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger CHORD PF04968.7 ERZ96640.1 - 0.41 10.9 11.1 1.1 9.6 0.4 2.9 2 1 0 2 2 2 0 CHORD ZF-HD_dimer PF04770.7 ERZ96640.1 - 0.73 9.9 5.5 4.2 7.4 0.0 3.0 1 1 1 2 2 2 0 ZF-HD protein dimerisation region Dimer_Tnp_hAT PF05699.9 ERZ96641.1 - 0.00095 18.7 0.1 0.0024 17.4 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-U1 PF06220.7 ERZ96641.1 - 0.58 9.7 4.6 0.13 11.8 0.5 2.0 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_jaz PF12171.3 ERZ96641.1 - 8.3 6.6 8.5 0.35 11.0 1.2 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding F-box PF00646.28 ERZ96642.1 - 0.0017 17.9 2.6 0.009 15.6 0.9 2.9 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.2 ERZ96642.1 - 0.0081 15.8 1.5 0.0081 15.8 1.1 2.3 2 0 0 2 2 2 1 F-box-like PBP1_TM PF14812.1 ERZ96642.1 - 4.4 7.6 6.9 7.4 6.9 4.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.7 ERZ96642.1 - 4.5 6.4 8.6 2.3 7.4 4.4 1.6 2 0 0 2 2 2 0 NOA36 protein Sec63 PF02889.11 ERZ96645.1 - 5.5e-97 324.7 2.2 1.1e-96 323.7 1.5 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 ERZ96645.1 - 2.4e-53 180.1 0.5 2.5e-26 92.1 0.2 3.4 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.10 ERZ96645.1 - 3.1e-21 76.0 1.5 2.4e-09 37.3 0.0 3.4 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ERZ96645.1 - 2.3e-15 56.1 0.0 3.6e-06 26.7 0.0 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 ERZ96645.1 - 1.4e-07 31.7 0.6 0.0061 16.6 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ERZ96645.1 - 0.00039 20.1 0.0 0.2 11.4 0.0 3.2 3 0 0 3 3 3 1 Part of AAA domain PhoH PF02562.11 ERZ96645.1 - 0.00075 18.7 0.0 0.4 9.8 0.0 3.1 3 0 0 3 3 3 1 PhoH-like protein AAA_30 PF13604.1 ERZ96645.1 - 0.0022 17.5 0.0 2.4 7.7 0.0 3.3 4 0 0 4 4 4 2 AAA domain T2SE PF00437.15 ERZ96645.1 - 0.0024 16.8 0.0 0.26 10.1 0.0 2.7 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.12 ERZ96645.1 - 0.0072 15.7 0.3 5.3 6.4 0.0 3.5 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_25 PF13481.1 ERZ96645.1 - 0.011 15.0 0.0 2.3 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ERZ96645.1 - 0.026 13.9 0.0 7.5 5.8 0.0 4.0 4 0 0 4 4 4 0 AAA-like domain FtsK_SpoIIIE PF01580.13 ERZ96645.1 - 0.046 13.1 0.0 5.1 6.5 0.0 2.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family DDE_1 PF03184.14 ERZ96653.1 - 6e-36 123.6 0.0 1.4e-18 66.8 0.0 2.1 2 0 0 2 2 2 2 DDE superfamily endonuclease Fve PF09259.6 ERZ96653.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Fungal immunomodulatory protein Fve ubiquitin PF00240.18 ERZ96655.1 - 1.9e-14 52.7 0.1 3.8e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96655.1 - 0.0027 17.3 0.0 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ERZ96655.1 - 0.0042 16.5 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ERZ96655.1 - 0.067 12.5 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Pkinase_Tyr PF07714.12 ERZ96656.1 - 6.8e-37 126.9 0.0 8.9e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96656.1 - 6.1e-34 117.3 0.0 1e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TraT PF05818.7 ERZ96656.1 - 0.18 11.1 0.1 0.29 10.5 0.1 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Myb_DNA-bind_6 PF13921.1 ERZ96657.1 - 2.2e-06 27.6 0.2 2.2e-06 27.6 0.1 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ERZ96657.1 - 1.3e-05 25.1 0.0 1.3e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ96658.1 - 0.02 14.9 1.2 0.19 11.8 0.7 2.2 1 1 0 1 1 1 0 Myb-like DNA-binding domain DDE_3 PF13358.1 ERZ96660.1 - 5.7e-06 26.1 0.5 7.4e-06 25.7 0.3 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Unstab_antitox PF09720.5 ERZ96660.1 - 0.064 12.9 0.3 0.14 11.8 0.2 1.7 1 1 0 1 1 1 0 Putative addiction module component BTB PF00651.26 ERZ96661.1 - 1.4e-15 57.2 0.1 1.6e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ERZ96662.1 - 2.5e-19 69.2 0.1 4.8e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96662.1 - 3.9e-10 39.4 7.8 3.5e-08 33.2 1.0 3.9 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ERZ96663.1 - 6.2e-13 48.9 3.6 2.5e-12 46.9 1.2 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ96663.1 - 1.8e-09 37.3 0.6 6.7e-09 35.5 0.2 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ96664.1 - 4.3e-20 71.7 0.1 6e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96664.1 - 0.0025 17.6 3.5 0.82 9.5 0.1 3.6 4 0 0 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ96664.1 - 0.0049 16.0 0.0 0.0067 15.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BACK PF07707.10 ERZ96665.1 - 3.2e-09 36.5 0.9 2.2e-06 27.4 0.1 2.1 2 0 0 2 2 2 2 BTB And C-terminal Kelch DUF2434 PF10361.4 ERZ96665.1 - 0.0003 19.9 0.1 0.00038 19.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) SSB PF00436.20 ERZ96666.1 - 0.044 13.6 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Single-strand binding protein family Herpes_PAP PF03325.8 ERZ96668.1 - 0.062 12.8 0.1 0.076 12.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein DUF2621 PF11084.3 ERZ96669.1 - 0.1 12.2 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) BACK PF07707.10 ERZ96670.1 - 2e-07 30.8 0.7 7.4e-07 28.9 0.3 1.8 1 1 1 2 2 2 1 BTB And C-terminal Kelch RPM2 PF08579.6 ERZ96670.1 - 0.11 12.6 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) DUF3969 PF13108.1 ERZ96673.1 - 0.041 13.5 0.2 0.099 12.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3969) MMR_HSR1 PF01926.18 ERZ96677.1 - 1.2e-06 28.4 0.0 0.014 15.3 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase RHD3 PF05879.7 ERZ96677.1 - 8.9e-06 23.9 0.1 8.9e-06 23.9 0.1 4.3 4 1 1 5 5 4 2 Root hair defective 3 GTP-binding protein (RHD3) AAA_29 PF13555.1 ERZ96677.1 - 0.00036 19.9 0.0 1.1 8.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 ERZ96677.1 - 0.00052 20.4 0.0 3 8.3 0.0 3.6 3 0 0 3 3 3 2 Miro-like protein Dynamin_N PF00350.18 ERZ96677.1 - 0.00083 19.2 0.8 0.013 15.3 0.1 3.8 4 1 0 4 4 3 2 Dynamin family AAA_28 PF13521.1 ERZ96677.1 - 0.003 17.5 0.0 0.68 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ERZ96677.1 - 0.0064 16.3 0.1 4.9 7.0 0.0 3.0 2 0 0 2 2 2 2 AAA domain FeoB_N PF02421.13 ERZ96677.1 - 0.027 13.7 0.4 3.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.22 ERZ96677.1 - 0.08 13.2 5.3 6.4 7.0 0.0 3.7 3 0 0 3 3 3 0 ABC transporter AAA_17 PF13207.1 ERZ96677.1 - 0.083 13.7 6.1 3.1 8.6 0.0 4.4 5 0 0 5 5 4 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ96677.1 - 0.11 11.9 0.1 6 6.2 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family HypA PF01155.14 ERZ96678.1 - 0.077 12.6 2.9 1.3 8.7 0.1 2.8 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family Glyco_hydro_80 PF13647.1 ERZ96679.1 - 0.12 11.5 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 80 of chitosanase A FAA_hydrolase PF01557.13 ERZ96681.1 - 3.8e-63 212.8 0.0 5.1e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family RNA_pol_Rpb2_3 PF04565.11 ERZ96682.1 - 0.12 12.1 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 3 GPI-anchored PF10342.4 ERZ96687.1 - 4e-09 36.8 0.2 3.3e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family TraW_N PF12477.3 ERZ96687.1 - 0.15 12.0 0.4 0.81 9.7 0.0 2.2 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal DASH_Duo1 PF08651.5 ERZ96688.1 - 0.056 13.0 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 DASH complex subunit Duo1 Sel1 PF08238.7 ERZ96689.1 - 1.1e-32 111.7 7.9 5.8e-10 39.4 0.0 5.7 5 1 1 6 6 6 5 Sel1 repeat TPR_11 PF13414.1 ERZ96689.1 - 7.6e-05 22.2 9.8 0.0088 15.6 1.4 3.7 2 1 2 4 4 4 3 TPR repeat TPR_6 PF13174.1 ERZ96689.1 - 0.0019 18.5 3.9 3.9 8.1 0.0 4.9 5 1 1 6 6 6 1 Tetratricopeptide repeat SNAP PF14938.1 ERZ96689.1 - 0.0078 15.3 2.4 19 4.2 0.0 3.7 3 2 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ERZ96689.1 - 0.0087 15.9 5.7 0.26 11.2 0.4 4.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ96689.1 - 0.01 15.5 15.0 5.7 6.9 0.7 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.13 ERZ96689.1 - 0.018 14.8 6.9 0.8 9.6 3.7 3.8 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ERZ96689.1 - 0.028 14.1 4.2 4.9 7.1 0.2 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat BTB PF00651.26 ERZ96692.1 - 2.1e-18 66.2 0.1 4e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ96692.1 - 8.2e-08 32.0 0.4 1.7e-05 24.5 0.0 3.0 2 1 1 3 3 3 2 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ERZ96693.1 - 1.7e-41 142.0 0.0 3.1e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96693.1 - 2.5e-36 125.1 0.1 8.7e-36 123.3 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain DUF3753 PF12575.3 ERZ96693.1 - 0.012 15.4 0.2 0.092 12.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) BCS1_N PF08740.6 ERZ96693.1 - 0.027 14.1 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 BCS1 N terminal Zn_Tnp_IS91 PF14319.1 ERZ96693.1 - 0.11 11.9 7.1 0.083 12.4 1.2 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain DZR PF12773.2 ERZ96693.1 - 2.8 7.8 13.6 0.35 10.7 1.7 2.5 2 0 0 2 2 2 0 Double zinc ribbon ubiquitin PF00240.18 ERZ96695.1 - 1.7e-18 65.7 0.8 2.9e-18 65.0 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96695.1 - 4.6e-07 29.4 0.4 8.4e-07 28.5 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ96695.1 - 0.026 14.7 0.2 0.076 13.2 0.2 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain PARP PF00644.15 ERZ96695.1 - 0.061 12.7 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain FAR1 PF03101.10 ERZ96696.1 - 1e-08 35.5 3.7 1e-08 35.5 2.6 1.8 2 0 0 2 2 2 1 FAR1 DNA-binding domain SUR7 PF06687.7 ERZ96696.1 - 0.25 10.8 1.9 0.36 10.3 1.3 1.2 1 0 0 1 1 1 0 SUR7/PalI family AFT PF08731.6 ERZ96696.1 - 0.94 9.6 7.4 2.1 8.5 5.1 1.7 1 1 0 1 1 1 0 Transcription factor AFT DBD_Tnp_Mut PF03108.10 ERZ96697.1 - 0.00087 18.8 0.0 0.0017 17.8 0.0 1.5 1 0 0 1 1 1 1 MuDR family transposase Lig_chan-Glu_bd PF10613.4 ERZ96697.1 - 0.1 12.5 0.2 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site Ribonuc_L-PSP PF01042.16 ERZ96697.1 - 0.11 12.1 0.1 0.8 9.4 0.0 2.0 2 0 0 2 2 2 0 Endoribonuclease L-PSP FAR1 PF03101.10 ERZ96697.1 - 0.14 12.6 2.9 11 6.6 0.1 2.5 1 1 1 2 2 2 0 FAR1 DNA-binding domain Prenyltransf PF01255.14 ERZ96698.1 - 0.089 11.9 0.3 0.14 11.2 0.1 1.4 1 1 0 1 1 1 0 Putative undecaprenyl diphosphate synthase YcbB PF08664.5 ERZ96698.1 - 0.13 12.0 0.3 0.17 11.7 0.2 1.2 1 0 0 1 1 1 0 YcbB domain Dimer_Tnp_hAT PF05699.9 ERZ96699.1 - 5.3e-09 35.5 0.3 7.6e-09 35.0 0.0 1.3 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Sigma70_ner PF04546.8 ERZ96703.1 - 0.0027 17.3 0.4 0.0029 17.2 0.3 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region BTB PF00651.26 ERZ96704.1 - 4.6e-19 68.4 0.4 6.6e-19 67.9 0.1 1.4 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ96704.1 - 0.02 14.6 5.4 0.9 9.4 0.0 3.7 3 1 1 4 4 4 0 BTB And C-terminal Kelch DUF3582 PF12122.3 ERZ96704.1 - 0.036 14.0 0.3 0.077 12.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3582) DUF1539 PF07560.6 ERZ96708.1 - 1 9.2 4.4 4.4 7.1 3.1 2.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) OTT_1508_deam PF14441.1 ERZ96709.1 - 1e-11 44.8 0.1 1.8e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 OTT_1508-like deaminase DUF505 PF04458.7 ERZ96709.1 - 0.038 12.1 0.0 0.056 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) TLD PF07534.11 ERZ96711.1 - 5e-07 29.8 0.9 5e-07 29.8 0.6 2.1 2 1 0 2 2 2 1 TLD BTB PF00651.26 ERZ96713.1 - 2.7e-14 53.0 0.1 4.9e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96713.1 - 1.1e-09 38.4 0.1 2.4e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ96713.1 - 0.00062 19.5 1.4 0.13 12.0 0.1 3.4 2 1 2 4 4 4 2 BTB And C-terminal Kelch KIP1 PF07765.7 ERZ96714.1 - 0.007 16.1 0.4 0.016 15.0 0.1 1.7 2 0 0 2 2 2 1 KIP1-like protein Ribosomal_L13 PF00572.13 ERZ96714.1 - 0.011 15.8 1.3 0.014 15.4 0.7 1.4 1 1 0 1 1 1 0 Ribosomal protein L13 tRNA-synt_1b PF00579.20 ERZ96714.1 - 0.05 12.7 1.7 0.062 12.4 1.2 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) TMF_TATA_bd PF12325.3 ERZ96714.1 - 0.067 12.9 3.5 0.07 12.8 0.2 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding SseC PF04888.7 ERZ96714.1 - 0.12 11.7 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF2666 PF10869.3 ERZ96714.1 - 5.1 7.1 8.6 0.98 9.4 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2666) DUF325 PF03804.8 ERZ96715.1 - 0.022 14.4 1.2 10 5.9 0.1 3.2 2 1 1 3 3 3 0 Viral domain of unknown function Pox_A3L PF05288.6 ERZ96715.1 - 0.18 11.5 6.1 4.5 7.0 0.0 3.7 3 1 0 3 3 3 0 Poxvirus A3L Protein Spuma_A9PTase PF03539.9 ERZ96716.1 - 0.053 13.4 0.0 0.066 13.1 0.0 1.1 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) MMR_HSR1 PF01926.18 ERZ96717.1 - 1.5e-07 31.3 0.0 0.00089 19.2 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase RHD3 PF05879.7 ERZ96717.1 - 6.5e-06 24.3 0.1 6.5e-06 24.3 0.0 4.5 3 1 1 5 5 5 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 ERZ96717.1 - 9.6e-05 22.2 10.6 0.0028 17.4 0.0 3.9 3 1 0 3 3 3 2 Dynamin family AAA_28 PF13521.1 ERZ96717.1 - 0.00073 19.5 0.0 0.95 9.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 ERZ96717.1 - 0.0011 19.4 0.0 0.71 10.3 0.0 3.1 2 0 0 2 2 2 1 Miro-like protein AAA_29 PF13555.1 ERZ96717.1 - 0.0013 18.2 0.0 1.6 8.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.1 ERZ96717.1 - 0.014 15.3 0.0 6 6.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ96717.1 - 0.1 12.0 0.0 3.9 6.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_17 PF13207.1 ERZ96717.1 - 0.18 12.6 6.1 6.9 7.5 0.0 4.9 5 1 0 5 5 5 0 AAA domain ABC_tran PF00005.22 ERZ96717.1 - 0.22 11.8 4.8 8.8 6.6 0.0 3.5 3 0 0 3 3 3 0 ABC transporter zf-C2H2 PF00096.21 ERZ96719.1 - 5.1e-12 45.3 19.6 1.1e-06 28.5 3.3 2.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ERZ96719.1 - 5.3e-10 39.0 19.0 1.4e-09 37.7 2.2 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ERZ96719.1 - 2.1e-09 37.0 14.1 0.00019 21.5 3.1 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ERZ96719.1 - 0.0011 18.8 12.5 0.011 15.6 0.2 2.6 3 0 0 3 3 3 2 C2H2-type zinc finger TP1 PF02079.11 ERZ96719.1 - 0.015 15.0 5.5 0.015 15.0 3.8 1.9 1 1 1 2 2 2 0 Nuclear transition protein 1 zf-TRAF PF02176.13 ERZ96719.1 - 0.019 15.3 4.5 0.025 14.9 3.1 1.2 1 0 0 1 1 1 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.3 ERZ96719.1 - 0.056 13.5 9.3 1.1 9.4 0.2 2.5 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Neuropeptide_S PF14993.1 ERZ96719.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Neuropeptide S precursor protein zf-LYAR PF08790.6 ERZ96719.1 - 0.27 10.9 1.9 8.5 6.1 0.2 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.2 ERZ96719.1 - 8.2 6.6 8.1 6.4 6.9 2.3 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) YmzC PF14157.1 ERZ96720.1 - 0.017 14.9 0.8 0.04 13.7 0.4 1.7 1 1 0 1 1 1 0 YmzC-like protein MAM33 PF02330.11 ERZ96720.1 - 0.035 13.8 0.7 0.044 13.5 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial glycoprotein DASH_Dad4 PF08650.5 ERZ96720.1 - 0.073 12.9 1.1 3.6 7.5 0.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad4 MetRS-N PF09635.5 ERZ96721.1 - 0.05 13.9 0.0 0.084 13.2 0.0 1.4 1 1 0 1 1 1 0 MetRS-N binding domain Bac_DnaA PF00308.13 ERZ96722.1 - 0.001 18.8 0.0 0.0029 17.2 0.0 1.7 2 0 0 2 2 2 1 Bacterial dnaA protein Arch_ATPase PF01637.13 ERZ96722.1 - 0.0012 18.6 0.5 0.0033 17.1 0.2 1.9 1 1 1 2 2 2 1 Archaeal ATPase NACHT PF05729.7 ERZ96722.1 - 0.019 14.6 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF2080 PF09853.4 ERZ96722.1 - 0.051 13.3 0.7 0.73 9.6 0.1 2.6 2 0 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) IstB_IS21 PF01695.12 ERZ96722.1 - 0.075 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ArgK PF03308.11 ERZ96722.1 - 0.18 10.5 0.0 0.31 9.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein MHC2-interact PF09307.5 ERZ96722.1 - 0.26 11.0 0.7 0.73 9.6 0.5 1.7 2 0 0 2 2 2 0 CLIP, MHC2 interacting QLQ PF08880.6 ERZ96723.1 - 0.02 14.2 1.0 0.041 13.2 0.7 1.4 1 0 0 1 1 1 0 QLQ Rubis-subs-bind PF09273.6 ERZ96724.1 - 6.7e-19 68.0 0.0 1.1e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.23 ERZ96724.1 - 1.7e-09 38.2 0.0 1.1e-08 35.5 0.0 2.0 1 1 0 1 1 1 1 SET domain DUF1667 PF07892.6 ERZ96724.1 - 0.13 12.0 0.0 1.7 8.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1667) DUF1542 PF07564.6 ERZ96726.1 - 0.025 14.5 1.6 0.14 12.1 0.1 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1542) Ras PF00071.17 ERZ96727.1 - 0.03 13.7 0.1 0.11 11.8 0.0 2.0 2 0 0 2 2 2 0 Ras family AAA_29 PF13555.1 ERZ96727.1 - 0.079 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAP3 PF10236.4 ERZ96727.1 - 0.093 11.6 0.0 0.23 10.3 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 HEXIM PF15313.1 ERZ96728.1 - 0.045 13.9 0.1 0.049 13.7 0.1 1.2 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein Oxidored_q6 PF01058.17 ERZ96729.1 - 9.5e-23 80.2 0.2 1.2e-22 79.8 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Hist_deacetyl PF00850.14 ERZ96730.1 - 3.1e-79 266.5 0.0 3.6e-79 266.2 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase_Tyr PF07714.12 ERZ96732.1 - 9.6e-43 146.1 0.0 1.4e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96732.1 - 2e-40 138.5 1.6 2.1e-40 138.4 0.2 1.7 1 1 1 2 2 2 1 Protein kinase domain Zn_Tnp_IS91 PF14319.1 ERZ96732.1 - 0.0016 17.9 1.0 0.0038 16.7 0.7 1.6 1 0 0 1 1 1 1 Transposase zinc-binding domain zf-C3HC4_3 PF13920.1 ERZ96732.1 - 0.056 13.1 0.5 0.14 11.8 0.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BCS1_N PF08740.6 ERZ96732.1 - 0.086 12.4 0.5 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 BCS1 N terminal Zn-ribbon_8 PF09723.5 ERZ96732.1 - 0.11 12.4 1.8 0.27 11.2 1.2 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-MYND PF01753.13 ERZ96734.1 - 4.5e-11 42.4 19.2 4.5e-11 42.4 13.3 2.8 3 0 0 3 3 3 2 MYND finger HCO3_cotransp PF00955.16 ERZ96736.1 - 0.014 14.1 1.6 0.026 13.2 1.1 1.4 1 0 0 1 1 1 0 HCO3- transporter family DUF4446 PF14584.1 ERZ96736.1 - 0.36 10.6 6.0 0.1 12.4 0.8 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) MSC PF09402.5 ERZ96736.1 - 0.41 9.3 6.4 0.027 13.2 0.5 1.8 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain YjgP_YjgQ PF03739.9 ERZ96736.1 - 7.7 5.1 17.0 0.14 10.8 1.6 2.7 3 0 0 3 3 3 0 Predicted permease YjgP/YjgQ family IRF-2BP1_2 PF11261.3 ERZ96737.1 - 0.037 13.4 0.5 0.11 11.9 0.4 1.8 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger PPR PF01535.15 ERZ96739.1 - 0.12 12.3 0.2 21 5.3 0.0 3.4 3 0 0 3 3 3 0 PPR repeat Atrophin-1 PF03154.10 ERZ96739.1 - 0.23 9.5 3.7 0.31 9.1 2.5 1.3 1 0 0 1 1 1 0 Atrophin-1 family BTB PF00651.26 ERZ96741.1 - 7.9e-09 35.4 0.0 9.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Methyltransf_11 PF08241.7 ERZ96744.1 - 3.8e-08 33.7 0.0 6e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ96744.1 - 2.1e-07 30.8 0.0 2.4e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ96744.1 - 6.5e-06 26.6 0.0 8e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ96744.1 - 8.5e-06 26.0 0.0 1.2e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ96744.1 - 3.1e-05 23.6 0.0 4.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ96744.1 - 5.1e-05 22.4 0.0 7.4e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.10 ERZ96744.1 - 0.0057 16.2 0.0 0.007 16.0 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.7 ERZ96744.1 - 0.026 15.0 0.0 0.055 13.9 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Pkinase_Tyr PF07714.12 ERZ96746.1 - 9.6e-19 67.4 0.0 6.8e-10 38.4 0.0 3.1 1 1 2 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ERZ96746.1 - 2.3e-15 56.4 0.6 7.1e-06 25.3 0.2 3.8 1 1 2 3 3 3 3 Protein kinase domain AAA_2 PF07724.9 ERZ96747.1 - 2.2e-53 180.6 0.0 4.9e-51 173.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 ERZ96747.1 - 1e-24 86.2 1.1 4.2e-24 84.2 0.1 2.6 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 ERZ96747.1 - 1.5e-22 80.1 1.1 7.7e-11 42.3 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ96747.1 - 9.8e-16 57.7 0.0 1.6e-10 40.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ERZ96747.1 - 4.4e-10 39.8 6.9 0.0089 16.0 0.0 5.0 4 1 1 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 ERZ96747.1 - 6.7e-10 39.2 3.8 0.00012 22.2 0.0 4.0 3 1 0 3 3 3 2 AAA domain Sigma54_activat PF00158.21 ERZ96747.1 - 2.1e-09 37.0 0.1 3.9e-06 26.4 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.12 ERZ96747.1 - 2.1e-07 30.5 0.1 0.039 13.3 0.0 3.1 3 1 0 3 3 3 2 IstB-like ATP binding protein AAA_17 PF13207.1 ERZ96747.1 - 4.4e-07 30.7 7.2 0.0014 19.4 0.0 4.0 2 2 1 4 4 3 2 AAA domain AAA_14 PF13173.1 ERZ96747.1 - 6e-07 29.4 0.6 0.018 14.9 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.1 ERZ96747.1 - 8e-06 26.1 2.7 0.15 12.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.16 ERZ96747.1 - 0.00015 20.9 0.1 1.2 8.2 0.0 3.4 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 ERZ96747.1 - 0.00021 21.4 0.0 1.3 9.2 0.0 3.2 3 0 0 3 3 3 2 RNA helicase ABC_tran PF00005.22 ERZ96747.1 - 0.00037 20.7 1.1 0.2 11.9 0.0 3.3 3 0 0 3 3 3 1 ABC transporter NACHT PF05729.7 ERZ96747.1 - 0.00044 19.9 0.1 0.079 12.6 0.0 2.9 2 1 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.7 ERZ96747.1 - 0.00061 18.9 0.0 0.016 14.3 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin MobB PF03205.9 ERZ96747.1 - 0.00066 19.3 0.0 0.28 10.9 0.0 3.1 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B RuvB_N PF05496.7 ERZ96747.1 - 0.0011 18.0 2.5 0.31 10.0 0.0 3.4 3 1 0 3 3 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ERZ96747.1 - 0.0019 17.9 0.0 1.7 8.4 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_10 PF12846.2 ERZ96747.1 - 0.0022 17.4 0.1 0.18 11.2 0.0 3.0 2 1 0 2 2 2 1 AAA-like domain AAA_24 PF13479.1 ERZ96747.1 - 0.0024 17.4 0.0 0.14 11.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 ERZ96747.1 - 0.004 17.1 0.0 0.48 10.3 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.1 ERZ96747.1 - 0.0041 17.0 0.3 7.1 6.5 0.0 3.6 3 1 0 3 3 3 0 AAA domain DUF258 PF03193.11 ERZ96747.1 - 0.0055 15.9 0.0 2.1 7.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 UPF0079 PF02367.12 ERZ96747.1 - 0.011 15.3 0.0 4.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 ERZ96747.1 - 0.011 14.6 0.0 0.093 11.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.1 ERZ96747.1 - 0.016 14.7 0.0 4.3 6.9 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 ERZ96747.1 - 0.017 14.6 0.0 0.28 10.6 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RepA_C PF04796.7 ERZ96747.1 - 0.021 14.4 0.0 0.065 12.8 0.0 1.7 2 0 0 2 2 1 0 Plasmid encoded RepA protein ResIII PF04851.10 ERZ96747.1 - 0.022 14.5 2.6 2.1 8.1 0.0 3.9 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit PduV-EutP PF10662.4 ERZ96747.1 - 0.025 14.0 0.0 2.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 ERZ96747.1 - 0.027 13.8 0.6 4.8 6.5 0.0 2.9 2 2 0 3 3 3 0 AAA domain Torsin PF06309.6 ERZ96747.1 - 0.028 14.3 0.0 0.19 11.6 0.0 2.3 3 0 0 3 3 2 0 Torsin SRP54 PF00448.17 ERZ96747.1 - 0.062 12.7 0.0 3.3 7.1 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Spc42p PF11544.3 ERZ96747.1 - 0.064 13.2 7.4 0.11 12.4 3.8 2.4 1 1 1 2 2 1 0 Spindle pole body component Spc42p AAA_30 PF13604.1 ERZ96747.1 - 0.069 12.7 0.0 15 5.0 0.0 3.0 2 1 0 2 2 2 0 AAA domain V_ATPase_I PF01496.14 ERZ96747.1 - 0.14 10.0 6.5 0.21 9.4 4.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.1 ERZ96747.1 - 0.16 12.2 22.9 0.99 9.6 0.0 3.5 2 1 0 2 2 1 0 AAA domain APG6 PF04111.7 ERZ96747.1 - 1 8.3 10.8 1.7 7.5 7.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 GTSE1_N PF15259.1 ERZ96748.1 - 0.24 11.3 4.5 0.73 9.7 3.1 1.8 1 1 0 1 1 1 0 G-2 and S-phase expressed 1 DNA_methylase PF00145.12 ERZ96749.1 - 6.2e-35 120.8 0.1 3.1e-34 118.6 0.0 1.8 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase DUF4598 PF15370.1 ERZ96750.1 - 4.7e-09 36.5 1.9 4.7e-09 36.5 1.3 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) DUF22 PF01629.11 ERZ96750.1 - 0.095 12.1 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF22 SurA_N_2 PF13623.1 ERZ96752.1 - 0.0032 17.4 0.1 0.0044 17.0 0.1 1.2 1 0 0 1 1 1 1 SurA N-terminal domain ORC5_C PF14630.1 ERZ96752.1 - 0.053 12.9 1.0 0.23 10.9 0.1 1.9 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus SurA_N_2 PF13623.1 ERZ96753.1 - 0.0039 17.1 0.2 0.015 15.2 0.2 2.0 1 0 0 1 1 1 1 SurA N-terminal domain SurA_N_2 PF13623.1 ERZ96754.1 - 0.0013 18.7 0.9 0.0036 17.2 0.7 1.7 1 0 0 1 1 1 1 SurA N-terminal domain Pkinase PF00069.20 ERZ96759.1 - 3.8e-32 111.4 0.0 5.4e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96759.1 - 4.3e-31 107.9 0.0 5.4e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AMP-binding PF00501.23 ERZ96761.1 - 1.5e-88 296.9 0.0 2e-88 296.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ERZ96761.1 - 5.1e-16 59.3 0.0 9.8e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF953 PF06110.6 ERZ96762.1 - 1.5e-31 108.3 0.0 1.7e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.1 ERZ96762.1 - 0.0022 17.5 0.1 0.0035 16.9 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin CAF1 PF04857.15 ERZ96763.1 - 1.2e-53 182.1 3.1 1.8e-53 181.5 2.2 1.3 1 0 0 1 1 1 1 CAF1 family ribonuclease RNA_bind PF08675.6 ERZ96763.1 - 0.0011 18.8 0.5 0.0073 16.2 0.0 2.3 1 1 1 2 2 2 1 RNA binding domain DUF2414 PF10309.4 ERZ96763.1 - 0.19 11.3 4.1 0.46 10.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2414) IF4E PF01652.13 ERZ96764.1 - 1.9e-54 183.6 0.3 3.3e-54 182.8 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Sel1 PF08238.7 ERZ96768.1 - 9.5e-128 413.8 71.9 1.6e-12 47.6 0.3 13.1 13 0 0 13 13 13 13 Sel1 repeat TPR_11 PF13414.1 ERZ96768.1 - 1.8e-10 40.2 65.4 0.004 16.7 4.3 9.7 2 1 10 12 12 12 9 TPR repeat TPR_16 PF13432.1 ERZ96768.1 - 3.2e-09 37.2 0.0 2.6 8.8 0.1 8.1 3 1 7 10 10 10 1 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ96768.1 - 5e-05 23.4 21.2 22 5.7 0.0 10.8 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ96768.1 - 0.0013 18.5 36.3 8.3 6.4 2.0 11.1 2 1 9 12 12 12 4 Tetratricopeptide repeat MIT PF04212.13 ERZ96768.1 - 0.03 14.1 30.2 0.69 9.8 0.0 9.6 11 1 1 12 12 12 0 MIT (microtubule interacting and transport) domain Aurora-A_bind PF09041.5 ERZ96768.1 - 0.031 14.0 1.9 9.4 6.0 0.0 4.2 5 0 0 5 5 5 0 Aurora-A binding DUF3047 PF11249.3 ERZ96768.1 - 0.075 12.4 4.6 41 3.4 0.0 5.1 5 1 1 6 6 6 0 Protein of unknown function (DUF3047) TFIIB PF00382.14 ERZ96768.1 - 0.12 12.1 7.3 29 4.5 0.0 6.2 8 0 0 8 8 8 0 Transcription factor TFIIB repeat HMG_box PF00505.14 ERZ96769.1 - 1.1e-09 38.3 5.5 2.9e-09 37.0 3.8 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ96769.1 - 0.0068 16.7 2.1 0.011 16.0 1.0 1.8 1 1 0 1 1 1 1 HMG-box domain Rubrerythrin PF02915.12 ERZ96769.1 - 0.033 14.5 1.0 0.033 14.5 0.7 1.9 2 0 0 2 2 2 0 Rubrerythrin CCDC84 PF14968.1 ERZ96769.1 - 0.33 10.4 4.2 0.41 10.0 0.5 2.2 2 0 0 2 2 2 0 Coiled coil protein 84 BTB PF00651.26 ERZ96770.1 - 1.5e-18 66.7 0.2 1.9e-18 66.4 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Kelch_5 PF13854.1 ERZ96771.1 - 3.4e-19 68.3 9.9 0.00022 21.0 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 ERZ96771.1 - 1.4e-18 66.2 8.9 3.4e-05 23.8 0.1 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ERZ96771.1 - 1.4e-14 53.2 15.2 1.4e-05 24.5 0.4 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ERZ96771.1 - 1.7e-13 49.7 0.5 0.0014 18.2 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ERZ96771.1 - 6.8e-13 48.1 4.5 0.051 13.3 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ96771.1 - 2.6e-12 46.5 1.4 0.01 15.9 0.1 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain ECIST_Cterm PF14784.1 ERZ96772.1 - 0.034 14.0 0.2 0.061 13.2 0.2 1.4 1 0 0 1 1 1 0 C-terminal domain of the ECSIT protein DUF553 PF04473.7 ERZ96773.1 - 0.064 12.5 0.0 0.066 12.4 0.0 1.1 1 0 0 1 1 1 0 Transglutaminase-like domain VWA PF00092.23 ERZ96774.1 - 0.11 12.1 3.4 0.11 12.2 2.1 1.3 1 1 0 1 1 1 0 von Willebrand factor type A domain SPT6_acidic PF14632.1 ERZ96774.1 - 0.51 10.5 5.6 0.24 11.5 0.2 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 His_Phos_2 PF00328.17 ERZ96778.1 - 1e-35 123.7 0.3 1.2e-35 123.5 0.2 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) BTB PF00651.26 ERZ96779.1 - 2.6e-11 43.5 0.0 4.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ96779.1 - 0.00011 22.2 0.2 0.00033 20.6 0.2 1.9 1 0 0 1 1 1 1 TLD DUF2708 PF10917.3 ERZ96779.1 - 3.1 7.6 6.0 30 4.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2708) zf-C2H2 PF00096.21 ERZ96780.1 - 8.8e-16 57.2 95.8 0.0049 17.1 0.6 12.2 12 0 0 12 12 12 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ96780.1 - 2e-12 46.4 82.6 0.1 13.0 0.2 12.5 12 0 0 12 12 12 10 C2H2-type zinc finger RPN7 PF10602.4 ERZ96782.1 - 1.6e-66 223.0 0.6 1.6e-66 223.0 0.4 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.22 ERZ96782.1 - 1.9e-17 63.5 2.1 3.2e-17 62.7 0.2 2.3 2 1 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 ERZ96782.1 - 0.0033 17.2 0.3 1.5 8.5 0.0 2.6 2 0 0 2 2 2 2 COP9 signalosome, subunit CSN8 TPR_11 PF13414.1 ERZ96782.1 - 0.011 15.3 3.1 0.13 11.9 0.0 2.9 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 ERZ96782.1 - 0.013 15.3 5.7 0.073 13.0 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF309 PF03745.9 ERZ96782.1 - 0.034 13.6 0.0 0.068 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF309) TPR_1 PF00515.23 ERZ96782.1 - 0.052 13.1 0.2 0.052 13.1 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat RNase_H PF00075.19 ERZ96783.1 - 4.2e-33 114.4 0.1 7.1e-33 113.7 0.1 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 ERZ96783.1 - 1.2e-18 66.8 2.8 2.8e-18 65.6 1.9 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.1 ERZ96783.1 - 5.6e-05 22.8 0.0 0.00075 19.2 0.0 2.3 1 1 0 1 1 1 1 Reverse transcriptase-like Tox-PLDMTX PF15645.1 ERZ96783.1 - 2.1 8.3 7.4 0.41 10.6 2.2 2.0 1 1 1 2 2 2 0 Dermonecrotoxin of the Papain-like fold WD40 PF00400.27 ERZ96784.1 - 2e-17 62.2 12.5 1e-05 25.1 1.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat Myc_N PF01056.13 ERZ96784.1 - 0.011 14.8 8.9 0.021 13.9 6.1 1.5 1 0 0 1 1 1 0 Myc amino-terminal region PAN_3 PF08277.7 ERZ96784.1 - 0.4 10.3 3.5 19 4.9 0.1 3.1 3 0 0 3 3 3 0 PAN-like domain DUF1676 PF07898.8 ERZ96784.1 - 1.3 9.3 5.1 2.3 8.5 2.8 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1676) MAGE PF01454.14 ERZ96785.1 - 3.6e-38 130.8 0.4 5.8e-38 130.1 0.3 1.3 1 0 0 1 1 1 1 MAGE family DUF2097 PF09870.4 ERZ96785.1 - 0.056 13.5 0.1 0.2 11.7 0.1 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) zf-C3HC4_3 PF13920.1 ERZ96786.1 - 1.6e-07 30.8 17.3 2.6e-07 30.1 12.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SDA1 PF05285.7 ERZ96786.1 - 0.0012 18.2 14.1 0.0019 17.5 9.8 1.2 1 0 0 1 1 1 1 SDA1 Lin-8 PF03353.10 ERZ96786.1 - 0.045 13.0 2.0 0.077 12.2 1.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Cation_ATPase_C PF00689.16 ERZ96786.1 - 3 7.3 6.9 0.32 10.5 0.9 2.1 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus Endonuclease_7 PF02945.10 ERZ96788.1 - 0.0025 17.4 0.6 0.005 16.5 0.1 1.8 2 0 0 2 2 2 1 Recombination endonuclease VII Dimer_Tnp_hAT PF05699.9 ERZ96789.1 - 8.1e-09 34.9 0.0 1e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ERZ96790.1 - 6.9e-37 126.9 0.0 8.2e-37 126.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96790.1 - 4.5e-33 114.4 0.0 5.5e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ96790.1 - 0.01 14.9 0.2 0.015 14.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ96790.1 - 0.032 13.9 0.2 0.047 13.4 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ERZ96790.1 - 0.083 12.2 0.1 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL MULE PF10551.4 ERZ96791.1 - 0.00028 21.0 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain Peptidase_M76 PF09768.4 ERZ96792.1 - 0.56 9.6 4.6 0.21 11.0 1.1 1.8 1 1 1 2 2 2 0 Peptidase M76 family bZIP_1 PF00170.16 ERZ96792.1 - 4.9 7.1 20.1 0.35 10.8 2.1 3.6 2 1 1 3 3 3 0 bZIP transcription factor DUF1189 PF06691.6 ERZ96792.1 - 6.4 6.0 9.6 0.27 10.5 2.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) Exo_endo_phos PF03372.18 ERZ96793.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family SurA_N_2 PF13623.1 ERZ96793.1 - 0.073 13.0 0.4 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 SurA N-terminal domain Toxin_41 PF15521.1 ERZ96793.1 - 0.11 11.6 0.5 0.78 8.8 0.1 2.0 1 1 1 2 2 2 0 Putative toxin 41 F-box-like PF12937.2 ERZ96795.1 - 4.1e-08 32.8 0.1 7.1e-08 32.0 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ96795.1 - 1.7e-05 24.3 0.4 3.5e-05 23.3 0.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like_2 PF13013.1 ERZ96795.1 - 0.0018 17.9 0.0 0.0028 17.3 0.0 1.4 1 0 0 1 1 1 1 F-box-like domain DXPR_C PF13288.1 ERZ96796.1 - 0.089 12.8 0.7 0.22 11.5 0.5 1.6 1 0 0 1 1 1 0 DXP reductoisomerase C-terminal domain DUF624 PF04854.9 ERZ96796.1 - 0.14 12.0 0.3 19 5.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Pkinase PF00069.20 ERZ96798.1 - 1.4e-24 86.6 0.0 1e-17 64.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96798.1 - 2.4e-19 69.4 0.0 3.8e-11 42.5 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase DUF659 PF04937.10 ERZ96799.1 - 4.9e-06 26.1 0.2 1.4e-05 24.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) RICH PF05062.7 ERZ96799.1 - 0.69 10.0 3.8 7.9 6.6 2.6 2.4 1 1 0 1 1 1 0 RICH domain AT_hook PF02178.14 ERZ96800.1 - 0.084 12.5 0.6 0.23 11.2 0.4 1.7 1 0 0 1 1 1 0 AT hook motif CBM_20 PF00686.14 ERZ96801.1 - 0.00021 20.8 0.0 0.00063 19.2 0.0 1.9 1 0 0 1 1 1 1 Starch binding domain Hrs_helical PF12210.3 ERZ96801.1 - 0.01 16.0 0.0 0.046 13.9 0.0 2.1 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate PH_4 PF15404.1 ERZ96802.1 - 1.3e-25 90.0 11.8 5.3e-23 81.5 7.1 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 ERZ96802.1 - 4.8e-08 33.1 13.0 0.0022 18.1 0.0 4.7 4 1 0 4 4 4 2 PH domain Spo7_2_N PF15407.1 ERZ96802.1 - 0.015 14.7 0.1 0.058 12.8 0.1 2.0 1 0 0 1 1 1 0 Sporulation protein family 7 CBM_20 PF00686.14 ERZ96803.1 - 0.0036 16.8 0.0 0.0081 15.7 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain Mito_carr PF00153.22 ERZ96804.1 - 2.7e-25 87.8 0.1 7.1e-20 70.5 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Nab1 PF04902.7 ERZ96804.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Conserved region in Nab1 Abhydrolase_1 PF00561.15 ERZ96805.1 - 1e-40 139.7 0.0 1.6e-40 139.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ERZ96805.1 - 1e-08 35.3 0.0 2.4e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 ERZ96805.1 - 0.027 14.3 0.0 0.09 12.6 0.0 1.8 1 0 0 1 1 1 0 TAP-like protein NPR3 PF03666.8 ERZ96807.1 - 0.1 11.1 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Herpes_UL25 PF01499.11 ERZ96807.1 - 0.1 10.8 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family ACBP PF00887.14 ERZ96808.1 - 0.13 11.9 1.1 0.24 11.0 0.8 1.4 1 1 0 1 1 1 0 Acyl CoA binding protein BTB PF00651.26 ERZ96809.1 - 1.7e-16 60.1 0.1 3.8e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Glyco_tranf_2_3 PF13641.1 ERZ96811.1 - 0.019 14.7 0.0 0.063 13.0 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 ACT_4 PF13291.1 ERZ96811.1 - 0.097 13.0 0.1 24 5.3 0.0 3.0 3 0 0 3 3 3 0 ACT domain DUF3504 PF12012.3 ERZ96812.1 - 0.14 11.9 3.0 0.15 11.7 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) TLD PF07534.11 ERZ96813.1 - 7.8e-14 51.8 0.5 1.1e-13 51.3 0.3 1.2 1 0 0 1 1 1 1 TLD Sed5p PF11416.3 ERZ96813.1 - 0.16 11.4 0.5 0.88 9.0 0.1 2.1 2 0 0 2 2 2 0 Integral membrane protein Sed5p Scytalone_dh PF02982.9 ERZ96814.1 - 0.025 14.1 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Scytalone dehydratase UBACT PF02134.16 ERZ96814.1 - 0.052 13.1 0.2 0.099 12.2 0.2 1.5 1 0 0 1 1 1 0 Repeat in ubiquitin-activating (UBA) protein MreB_Mbl PF06723.8 ERZ96815.1 - 0.00016 20.4 0.0 0.068 11.7 0.0 2.2 1 1 0 2 2 2 2 MreB/Mbl protein DJ-1_PfpI PF01965.19 ERZ96815.1 - 0.013 14.9 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family MreB_Mbl PF06723.8 ERZ96816.1 - 1.5e-08 33.6 0.0 0.0026 16.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ96816.1 - 0.0018 16.2 0.8 0.019 12.8 0.3 2.4 2 1 0 2 2 2 1 Hsp70 protein DJ-1_PfpI PF01965.19 ERZ96816.1 - 0.011 15.1 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family YfdX PF10938.3 ERZ96817.1 - 0.02 14.5 2.1 0.024 14.2 1.5 1.0 1 0 0 1 1 1 0 YfdX protein IF-2B PF01008.12 ERZ96817.1 - 0.19 10.6 3.4 0.25 10.3 2.3 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family DUF3958 PF13125.1 ERZ96817.1 - 5.3 6.9 10.7 2 8.3 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) DEAD PF00270.24 ERZ96819.1 - 3.1e-46 156.9 1.7 3.8e-46 156.6 0.1 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF4217 PF13959.1 ERZ96819.1 - 9.1e-28 95.6 0.1 2.1e-27 94.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 ERZ96819.1 - 1.4e-20 72.8 0.0 3.4e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ERZ96819.1 - 0.047 13.6 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain Josephin PF02099.12 ERZ96820.1 - 7.1e-28 97.2 0.3 1e-27 96.7 0.2 1.1 1 0 0 1 1 1 1 Josephin SAM_2 PF07647.12 ERZ96821.1 - 0.009 15.8 0.1 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1456 PF07308.8 ERZ96821.1 - 0.052 13.5 0.1 10 6.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) DUF1129 PF06570.6 ERZ96823.1 - 0.01 15.1 2.9 0.021 14.1 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Nodulin_late PF07127.6 ERZ96823.1 - 0.14 12.2 5.7 2.4 8.3 0.1 3.7 3 0 0 3 3 3 0 Late nodulin protein DUF3488 PF11992.3 ERZ96823.1 - 0.38 9.3 2.4 0.59 8.7 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) Pkinase_Tyr PF07714.12 ERZ96824.1 - 2.8e-34 118.3 0.0 4e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ96824.1 - 2.2e-28 99.1 0.0 3.6e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pox_F15 PF04596.7 ERZ96825.1 - 0.012 15.1 0.5 0.014 14.9 0.4 1.0 1 0 0 1 1 1 0 Poxvirus protein F15 Met_synt_B12 PF02965.12 ERZ96825.1 - 0.13 11.4 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Vitamin B12 dependent methionine synthase, activation domain Aldo_ket_red PF00248.16 ERZ96826.1 - 5.8e-06 25.3 0.0 1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 ERZ96828.1 - 3.6e-45 154.1 0.1 4.7e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96828.1 - 9e-45 152.7 0.0 1.1e-44 152.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ96828.1 - 0.00011 21.2 0.0 0.00067 18.6 0.0 2.0 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ERZ96828.1 - 0.00047 19.5 1.1 0.0016 17.8 0.6 1.9 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ERZ96828.1 - 0.0028 17.4 0.1 0.0076 16.0 0.1 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ96828.1 - 0.003 16.6 0.0 0.0045 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ERZ96828.1 - 0.0032 16.6 0.6 0.0093 15.2 0.4 1.7 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Vac_ImportDeg PF09783.4 ERZ96830.1 - 0.085 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Vacuolar import and degradation protein Rhabdo_matrix PF03397.9 ERZ96831.1 - 0.0064 15.8 0.2 0.017 14.4 0.2 1.6 1 1 0 1 1 1 1 Rhabdovirus matrix protein Baculo_11_kDa PF06143.6 ERZ96832.1 - 0.24 10.7 2.5 0.51 9.7 1.7 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family BPD_transp_1 PF00528.17 ERZ96833.1 - 0.019 14.4 11.1 0.38 10.2 0.5 2.1 2 0 0 2 2 2 0 Binding-protein-dependent transport system inner membrane component Sec66 PF09802.4 ERZ96833.1 - 0.13 11.6 0.2 0.2 11.0 0.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF3429 PF11911.3 ERZ96833.1 - 0.2 11.6 2.4 0.26 11.2 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3429) CTP_transf_1 PF01148.15 ERZ96833.1 - 3.1 7.3 14.7 4.5 6.8 1.2 2.1 1 1 1 2 2 2 0 Cytidylyltransferase family zf-DHHC PF01529.15 ERZ96833.1 - 6.2 6.1 18.8 4e+02 0.2 13.0 2.1 1 1 0 1 1 1 0 DHHC palmitoyltransferase PPPI_inhib PF14895.1 ERZ96834.1 - 0.05 12.3 2.0 0.053 12.2 1.4 1.0 1 0 0 1 1 1 0 Protein phosphatase 1 inhibitor DUF843 PF05814.6 ERZ96834.1 - 0.65 9.8 5.8 1.4 8.7 4.0 1.8 1 1 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) CDC45 PF02724.9 ERZ96835.1 - 0.86 7.5 7.5 1.2 7.0 5.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_helicase PF00910.17 ERZ96836.1 - 0.00096 19.2 0.1 0.0051 16.9 0.0 2.1 2 1 0 2 2 2 1 RNA helicase AAA_19 PF13245.1 ERZ96836.1 - 0.075 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 ERZ96836.1 - 0.14 12.2 0.3 0.18 11.9 0.2 1.4 1 1 0 1 1 1 0 AAA domain Kei1 PF08552.6 ERZ96837.1 - 0.0011 18.7 0.4 0.0013 18.4 0.3 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 7tm_7 PF08395.7 ERZ96837.1 - 0.063 12.2 1.2 0.08 11.9 0.9 1.1 1 0 0 1 1 1 0 7tm Chemosensory receptor Reticulon PF02453.12 ERZ96837.1 - 0.082 12.5 0.4 0.099 12.2 0.3 1.4 1 0 0 1 1 1 0 Reticulon DUF2547 PF10818.3 ERZ96837.1 - 0.19 12.3 2.2 0.29 11.7 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2547) HSP20 PF00011.16 ERZ96841.1 - 1.4e-05 24.8 0.3 1.8e-05 24.5 0.2 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family BON PF04972.12 ERZ96841.1 - 0.085 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 BON domain RRM_5 PF13893.1 ERZ96843.1 - 0.044 13.6 0.0 0.094 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ERZ96843.1 - 0.11 12.1 0.1 0.43 10.2 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 ERZ96844.1 - 8.1e-22 77.6 0.0 1.8e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96844.1 - 2.5e-16 59.5 0.0 3.8e-16 58.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3279 PF11682.3 ERZ96844.1 - 0.0011 18.4 1.0 0.022 14.3 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3279) APH PF01636.18 ERZ96844.1 - 0.05 13.3 0.1 0.074 12.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Alginate_exp PF13372.1 ERZ96847.1 - 0.11 11.1 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Alginate export Sel1 PF08238.7 ERZ96848.1 - 1e-57 191.3 16.7 2.4e-13 50.2 1.0 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ96848.1 - 1.2e-06 28.6 10.0 0.71 10.4 0.2 5.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ96848.1 - 0.038 14.6 3.8 1.7 9.4 1.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.19 ERZ96848.1 - 0.094 12.7 0.5 6.4 6.8 0.1 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family MIT PF04212.13 ERZ96848.1 - 0.27 11.1 16.4 14 5.6 0.2 5.3 5 2 1 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ERZ96848.1 - 0.48 10.1 25.7 6.8 6.4 3.9 4.6 2 2 4 6 6 6 0 TPR repeat ARL2_Bind_BART PF11527.3 ERZ96849.1 - 0.1 12.3 0.7 0.14 11.9 0.5 1.4 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART rve_2 PF13333.1 ERZ96849.1 - 0.21 11.6 2.3 5.5 7.1 0.1 3.1 3 0 0 3 3 3 0 Integrase core domain Pkinase_Tyr PF07714.12 ERZ96851.1 - 3.2e-07 29.6 0.0 5.1e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_5 PF13306.1 ERZ96851.1 - 0.00081 19.1 10.8 0.0098 15.5 1.0 2.0 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) Pkinase PF00069.20 ERZ96851.1 - 0.03 13.4 0.0 0.059 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain SF3a60_bindingd PF12108.3 ERZ96851.1 - 0.064 12.8 1.5 0.16 11.5 1.0 1.7 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain SAM_1 PF00536.25 ERZ96853.1 - 0.0021 18.1 0.0 0.0048 17.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CEP44 PF15007.1 ERZ96853.1 - 0.028 14.1 0.1 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 Wx5_PLAF3D7 PF09688.5 ERZ96854.1 - 0.051 13.5 1.8 0.091 12.7 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) Trypsin_2 PF13365.1 ERZ96855.1 - 0.0067 16.4 0.1 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 ERZ96855.1 - 0.059 12.9 6.7 0.23 11.0 4.6 2.1 1 1 0 1 1 1 0 Trypsin DUF4264 PF14084.1 ERZ96857.1 - 0.016 14.6 0.3 0.037 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4264) NmrA PF05368.8 ERZ96859.1 - 8.1e-39 133.2 0.1 9.3e-39 133.0 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ96859.1 - 2.3e-14 53.8 0.0 3.4e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ERZ96859.1 - 1e-06 28.7 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.13 ERZ96859.1 - 2.2e-05 24.4 0.0 6.3e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain Epimerase PF01370.16 ERZ96859.1 - 2.5e-05 23.8 0.0 4.3e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ERZ96859.1 - 2.9e-05 22.8 0.0 4.8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ERZ96859.1 - 3.2e-05 23.6 0.0 5.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 ERZ96859.1 - 0.00037 19.5 0.1 0.00054 19.0 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 ERZ96859.1 - 0.0012 19.2 0.0 0.0027 18.0 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 ERZ96859.1 - 0.042 13.7 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short_C2 PF13561.1 ERZ96859.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.15 ERZ96859.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF563 PF04577.9 ERZ96859.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF563) 3HCDH_N PF02737.13 ERZ96859.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DEAD PF00270.24 ERZ96860.1 - 6.7e-45 152.6 0.0 2.3e-44 150.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ96860.1 - 7.4e-28 96.2 0.1 1.4e-27 95.3 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 ERZ96860.1 - 0.014 13.7 0.0 0.029 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1253) ResIII PF04851.10 ERZ96860.1 - 0.043 13.6 0.0 0.21 11.4 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Glyco_hydro_65C PF03633.10 ERZ96861.1 - 0.053 13.6 0.0 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, C-terminal domain APOBEC_C PF05240.9 ERZ96861.1 - 0.054 12.8 0.2 0.16 11.3 0.1 1.9 1 0 0 1 1 1 0 APOBEC-like C-terminal domain SAM_1 PF00536.25 ERZ96862.1 - 0.085 13.0 0.1 0.47 10.6 0.0 2.3 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DDE_3 PF13358.1 ERZ96863.1 - 0.0004 20.1 0.0 0.0004 20.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_IS630 PF01710.11 ERZ96864.1 - 1.2e-05 24.9 0.4 1.9e-05 24.2 0.3 1.3 1 1 0 1 1 1 1 Transposase HTH_23 PF13384.1 ERZ96864.1 - 2.8e-05 23.6 0.2 9e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain SusD-like_2 PF12771.2 ERZ96865.1 - 0.047 12.0 0.1 0.058 11.7 0.1 1.2 1 0 0 1 1 1 0 Starch-binding associating with outer membrane F-box-like PF12937.2 ERZ96866.1 - 0.026 14.2 0.3 0.056 13.1 0.2 1.6 1 0 0 1 1 1 0 F-box-like LAGLIDADG_3 PF14528.1 ERZ96866.1 - 1 9.6 3.3 23 5.3 2.3 2.2 1 1 0 1 1 1 0 LAGLIDADG-like domain CTI PF06934.6 ERZ96867.1 - 0.026 12.8 0.0 0.028 12.6 0.0 1.0 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) PDZ_1 PF12812.2 ERZ96873.1 - 5.8e-30 102.9 0.0 1.3e-23 82.7 0.0 2.9 2 0 0 2 2 2 2 PDZ-like domain PDZ_2 PF13180.1 ERZ96873.1 - 2.2e-19 69.0 0.5 1.6e-06 27.8 0.0 4.6 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.19 ERZ96873.1 - 7.5e-08 32.4 0.4 0.017 15.3 0.1 3.0 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Trypsin_2 PF13365.1 ERZ96873.1 - 1.3e-06 28.3 0.0 2.3e-05 24.3 0.0 2.5 2 0 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_S3 PF00944.14 ERZ96873.1 - 0.0093 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Alphavirus core protein Peptidase_S46 PF10459.4 ERZ96873.1 - 0.019 13.4 0.1 0.029 12.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.16 ERZ96873.1 - 0.062 12.7 0.6 0.15 11.4 0.4 1.6 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S31 PF05578.7 ERZ96873.1 - 0.16 11.1 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Pestivirus NS3 polyprotein peptidase S31 F-box-like PF12937.2 ERZ96874.1 - 5.9e-05 22.7 0.5 0.0002 21.0 0.4 1.9 1 0 0 1 1 1 1 F-box-like Autophagy_Cterm PF10381.4 ERZ96874.1 - 0.16 11.0 1.6 0.63 9.2 1.1 2.1 1 0 0 1 1 1 0 Autophagocytosis associated protein C-terminal T4-Gluco-transf PF09198.5 ERZ96875.1 - 0.17 11.2 1.8 0.53 9.6 0.4 2.1 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase mRNA_cap_enzyme PF01331.14 ERZ96876.1 - 3.6e-24 85.5 0.1 4.4e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.16 ERZ96876.1 - 7e-06 25.5 0.0 0.00091 18.6 0.0 2.1 1 1 0 1 1 1 1 ATP dependent DNA ligase domain CENP-Q PF13094.1 ERZ96877.1 - 3.3e-15 56.4 15.8 3.3e-15 56.4 11.0 1.5 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit MHC_I_2 PF14586.1 ERZ96877.1 - 0.031 13.8 0.0 0.072 12.6 0.0 1.6 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 C2 PF00168.25 ERZ96878.1 - 3.1e-20 71.8 0.0 7.6e-20 70.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.4 ERZ96878.1 - 2e-19 69.7 0.2 8.2e-19 67.7 0.1 2.2 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain W2 PF02020.13 ERZ96878.1 - 0.034 14.1 0.7 0.18 11.7 0.5 2.3 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon AKAP7_NLS PF10469.4 ERZ96879.1 - 1.3e-23 83.8 0.1 1.4e-23 83.7 0.1 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.1 ERZ96879.1 - 8.9e-07 28.7 0.0 1.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily CPDase PF07823.6 ERZ96879.1 - 0.07 12.6 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein ETF_QO PF05187.8 ERZ96880.1 - 1.3e-43 147.4 0.0 2.1e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase FAD_binding_2 PF00890.19 ERZ96880.1 - 7.7e-10 38.1 1.0 1.5e-05 24.0 1.3 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 ERZ96880.1 - 3e-08 32.9 1.7 0.00029 19.8 0.6 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ERZ96880.1 - 6e-07 29.3 0.0 2.3e-06 27.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ERZ96880.1 - 3.8e-06 26.1 0.1 6.3e-05 22.1 0.2 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 ERZ96880.1 - 3e-05 24.0 0.0 5.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ERZ96880.1 - 3.4e-05 23.0 0.1 6.6e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 ERZ96880.1 - 3.9e-05 23.4 0.2 0.00011 22.0 0.2 1.9 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.9 ERZ96880.1 - 0.00012 20.6 0.5 0.00021 19.8 0.3 1.3 1 0 0 1 1 1 1 HI0933-like protein Fer4_7 PF12838.2 ERZ96880.1 - 0.00048 20.4 1.2 0.0012 19.1 0.9 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Lycopene_cycl PF05834.7 ERZ96880.1 - 0.00052 19.0 0.2 0.00074 18.5 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.1 ERZ96880.1 - 0.00054 20.0 0.1 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 ERZ96880.1 - 0.0025 16.4 0.5 0.095 11.3 0.4 2.1 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.2 ERZ96880.1 - 0.004 16.2 0.0 0.0052 15.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ERZ96880.1 - 0.016 15.6 0.6 2.6 8.5 0.4 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ERZ96880.1 - 0.023 13.5 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.17 ERZ96880.1 - 0.044 12.6 0.4 0.068 12.0 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A TrkA_N PF02254.13 ERZ96880.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain RRM_1 PF00076.17 ERZ96881.1 - 1.9e-18 65.8 0.0 2.6e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ96881.1 - 7.8e-13 48.0 0.0 1.2e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ96881.1 - 3.2e-12 46.2 0.0 4.4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ERZ96881.1 - 7.1e-11 41.4 15.1 6.6e-06 25.8 1.7 2.7 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.1 ERZ96881.1 - 0.00028 20.5 7.9 0.045 13.4 1.0 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 ERZ96881.1 - 0.0038 16.9 6.6 0.07 12.8 0.3 2.4 1 1 1 2 2 2 2 Zinc knuckle Limkain-b1 PF11608.3 ERZ96881.1 - 0.061 13.0 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 Limkain b1 zf-CCHC_2 PF13696.1 ERZ96881.1 - 0.074 12.5 0.1 0.074 12.5 0.1 2.9 3 0 0 3 3 3 0 Zinc knuckle RRM_3 PF08777.6 ERZ96881.1 - 0.089 12.6 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 RNA binding motif zf-CCHC_5 PF14787.1 ERZ96881.1 - 6 6.4 13.2 7.9 6.0 1.5 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger LOH1CR12 PF10158.4 ERZ96882.1 - 3.3e-12 46.3 0.3 8.6e-12 44.9 0.2 1.7 1 0 0 1 1 1 1 Tumour suppressor protein TC1 PF15063.1 ERZ96882.1 - 0.038 13.5 0.0 0.18 11.3 0.0 2.2 1 0 0 1 1 1 0 Thyroid cancer protein 1 SUZ PF12752.2 ERZ96883.1 - 6.4e-11 42.6 0.1 1.9e-10 41.1 0.0 1.9 2 0 0 2 2 2 1 SUZ domain Aldo_ket_red PF00248.16 ERZ96884.1 - 1.7e-51 174.7 0.0 2e-51 174.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Herpes_teg_N PF04843.7 ERZ96884.1 - 0.019 14.4 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region RTTN_N PF14726.1 ERZ96884.1 - 0.023 15.2 0.0 0.052 14.1 0.0 1.5 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning Pkinase PF00069.20 ERZ96885.1 - 6.3e-67 225.4 0.0 7.5e-67 225.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96885.1 - 5.5e-25 87.9 0.0 7.6e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ96885.1 - 2.9e-07 29.7 0.0 8.8e-06 24.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ96885.1 - 0.0068 16.1 0.0 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ERZ96885.1 - 0.012 15.2 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.6 ERZ96885.1 - 0.027 13.1 0.5 0.06 11.9 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) ABC1 PF03109.11 ERZ96885.1 - 0.072 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 ABC1 family S_locus_glycop PF00954.15 ERZ96886.1 - 0.46 10.7 4.9 9.4 6.5 0.0 3.5 3 0 0 3 3 3 0 S-locus glycoprotein family FUN14 PF04930.10 ERZ96886.1 - 0.86 9.9 7.6 0.18 12.1 0.5 3.1 3 0 0 3 3 3 0 FUN14 family DUF1212 PF06738.7 ERZ96886.1 - 2.8 7.3 5.4 19 4.6 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) Mig-14 PF07395.6 ERZ96887.1 - 0.0099 14.9 0.0 0.034 13.1 0.0 1.7 1 1 1 2 2 2 1 Mig-14 Cation_efflux PF01545.16 ERZ96889.1 - 5.8e-49 166.6 4.8 7.2e-49 166.3 3.3 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ERZ96889.1 - 0.0035 16.4 18.3 0.0036 16.3 12.2 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter Innate_immun PF12782.2 ERZ96889.1 - 0.22 10.7 17.0 0.29 10.2 11.8 1.1 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family NicO PF03824.11 ERZ96889.1 - 2.5 7.3 17.2 7.8 5.7 11.9 1.7 1 1 0 1 1 1 0 High-affinity nickel-transport protein Herpes_LMP1 PF05297.6 ERZ96889.1 - 6.5 5.5 17.0 0.7 8.7 7.9 1.9 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) DUF2946 PF11162.3 ERZ96889.1 - 7.9 6.7 11.6 4.8 7.4 4.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) Cation_efflux PF01545.16 ERZ96890.1 - 0.02 13.9 2.4 0.02 13.9 1.7 2.5 3 0 0 3 3 3 0 Cation efflux family PALP PF00291.20 ERZ96891.1 - 1.5e-76 257.5 1.1 1.9e-76 257.2 0.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 ERZ96891.1 - 8e-46 153.5 0.1 2.2e-25 88.0 0.0 2.6 3 0 0 3 3 3 2 C-terminal regulatory domain of Threonine dehydratase Adenylsucc_synt PF00709.16 ERZ96892.1 - 1.1e-166 554.7 0.0 1.2e-166 554.5 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Tcp11 PF05794.8 ERZ96893.1 - 1.2e-74 251.6 6.3 1.2e-74 251.6 4.4 2.3 2 0 0 2 2 2 1 T-complex protein 11 Piwi PF02171.12 ERZ96894.1 - 1.9e-103 345.6 0.0 2.8e-103 345.0 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ96894.1 - 2.5e-26 91.5 1.0 7.3e-26 90.0 0.7 1.8 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ96894.1 - 1.3e-16 59.7 0.0 3.2e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PCI PF01399.22 ERZ96895.1 - 1.4e-18 67.1 0.0 2.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 PCI domain DUF3317 PF11779.3 ERZ96896.1 - 1e-14 53.6 1.2 1.1e-14 53.5 0.6 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3317) DUF914 PF06027.7 ERZ96896.1 - 0.017 13.9 0.2 0.018 13.8 0.1 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) APG5 PF04106.7 ERZ96897.1 - 1.8e-63 213.5 0.0 2.4e-63 213.1 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 MCPsignal PF00015.16 ERZ96898.1 - 0.016 14.7 0.2 0.018 14.5 0.1 1.0 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PA28_beta PF02252.13 ERZ96898.1 - 0.12 11.8 0.2 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit PAF-AH_p_II PF03403.8 ERZ96898.1 - 0.12 10.6 0.1 0.12 10.6 0.1 1.0 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II CENP-F_leu_zip PF10473.4 ERZ96900.1 - 0.0039 17.0 9.0 0.0039 17.0 6.2 2.2 3 0 0 3 3 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FTO_CTD PF12934.2 ERZ96900.1 - 0.0068 15.9 0.8 0.0068 15.9 0.6 1.5 2 0 0 2 2 2 1 FTO C-terminal domain Pox_A_type_inc PF04508.7 ERZ96900.1 - 0.015 15.0 6.5 0.12 12.2 0.4 3.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat CENP-H PF05837.7 ERZ96900.1 - 0.027 14.6 7.8 0.027 14.6 5.4 2.9 2 1 1 3 3 3 0 Centromere protein H (CENP-H) bZIP_2 PF07716.10 ERZ96900.1 - 0.19 11.5 11.6 0.33 10.8 1.7 2.7 1 1 0 2 2 2 0 Basic region leucine zipper DUF342 PF03961.8 ERZ96900.1 - 0.2 10.0 10.4 0.013 13.9 3.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF342) TSC22 PF01166.13 ERZ96900.1 - 0.29 11.1 11.3 0.07 13.1 2.0 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family Seadorna_VP6 PF07407.6 ERZ96900.1 - 0.29 9.8 2.9 0.46 9.1 2.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein GAS PF13851.1 ERZ96900.1 - 0.54 9.4 14.8 1.5 7.9 7.2 2.7 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding KLRAQ PF10205.4 ERZ96900.1 - 0.69 9.9 10.8 0.15 12.0 4.2 2.4 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein Osmo_CC PF08946.5 ERZ96900.1 - 0.89 9.6 5.2 1.5 8.9 0.5 2.8 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DUF4337 PF14235.1 ERZ96900.1 - 0.96 9.2 10.4 0.29 10.9 4.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DivIC PF04977.10 ERZ96900.1 - 1.1 8.7 16.5 0.8 9.2 1.9 3.0 3 1 1 4 4 4 0 Septum formation initiator ADIP PF11559.3 ERZ96900.1 - 2.5 7.9 15.8 0.12 12.2 6.3 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Caldesmon PF02029.10 ERZ96900.1 - 2.7 6.2 21.4 0.091 11.1 8.2 2.0 1 1 1 2 2 2 0 Caldesmon Atg14 PF10186.4 ERZ96900.1 - 4 6.2 12.8 0.21 10.4 4.4 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4600 PF15372.1 ERZ96900.1 - 4.6 7.4 15.1 4.9 7.3 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) TBCA PF02970.11 ERZ96900.1 - 4.7 7.3 14.9 0.21 11.6 4.9 2.7 3 1 1 4 4 4 0 Tubulin binding cofactor A bZIP_1 PF00170.16 ERZ96900.1 - 5.3 7.0 16.6 1.4 8.9 2.4 3.2 2 1 2 4 4 4 0 bZIP transcription factor DUF972 PF06156.8 ERZ96900.1 - 6.5 7.1 16.8 1.6 9.1 6.5 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF972) DUF4315 PF14193.1 ERZ96900.1 - 6.8 6.6 17.2 7 6.6 5.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4315) NYD-SP28_assoc PF14775.1 ERZ96900.1 - 6.9 6.4 7.7 8.8 6.1 0.0 3.1 2 1 1 3 3 3 0 Sperm tail C-terminal domain Viral_P18 PF04521.8 ERZ96900.1 - 8 5.9 7.7 2.5 7.5 3.1 1.9 2 1 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein TMF_TATA_bd PF12325.3 ERZ96900.1 - 9.5 5.9 16.1 1.5 8.5 7.7 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4482 PF14818.1 ERZ96900.1 - 9.8 6.8 17.4 38 4.9 4.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) AAA_4 PF04326.9 ERZ96901.1 - 0.051 13.7 0.2 0.08 13.0 0.1 1.3 1 0 0 1 1 1 0 Divergent AAA domain DUF1160 PF06648.6 ERZ96901.1 - 0.073 12.8 0.1 0.63 9.8 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1160) HHH PF00633.18 ERZ96901.1 - 0.089 12.5 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_S13 PF00416.17 ERZ96901.1 - 0.14 12.5 0.2 0.3 11.5 0.2 1.7 1 1 0 1 1 1 0 Ribosomal protein S13/S18 Pkinase PF00069.20 ERZ96902.1 - 1.1e-08 34.5 0.1 1.4e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ96902.1 - 0.0035 16.6 0.3 0.0073 15.6 0.2 1.6 1 1 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 ERZ96902.1 - 0.013 14.5 0.3 0.022 13.8 0.2 1.5 1 1 0 1 1 1 0 Protein tyrosine kinase APH PF01636.18 ERZ96902.1 - 0.038 13.7 0.0 0.092 12.4 0.0 1.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF805 PF05656.9 ERZ96904.1 - 0.02 14.7 2.2 0.29 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Piwi PF02171.12 ERZ96906.1 - 9.1e-83 277.6 0.0 1.1e-82 277.4 0.0 1.0 1 0 0 1 1 1 1 Piwi domain DUF2762 PF10960.3 ERZ96906.1 - 0.023 14.3 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) TerD PF02342.13 ERZ96907.1 - 2.7e-12 46.3 0.0 4.6e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ96907.1 - 6.9e-08 31.7 0.5 2e-07 30.3 0.4 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96907.1 - 0.00056 19.5 0.2 0.0015 18.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Chitin_synth_1N PF08407.6 ERZ96908.1 - 7.8e-35 118.4 0.4 1.1e-34 117.9 0.3 1.2 1 0 0 1 1 1 1 Chitin synthase N-terminal Aminotran_5 PF00266.14 ERZ96909.1 - 7.2e-17 61.1 0.0 9.2e-17 60.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V UAA PF08449.6 ERZ96910.1 - 6.5e-80 268.2 22.0 7.7e-80 268.0 15.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ERZ96910.1 - 8.8e-10 38.7 26.7 1.5e-05 25.0 7.7 3.1 2 2 1 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 ERZ96910.1 - 3.1e-05 23.2 5.9 0.032 13.3 1.0 2.2 1 1 1 2 2 2 2 Nucleotide-sugar transporter DUF914 PF06027.7 ERZ96910.1 - 7.5e-05 21.7 10.9 7.5e-05 21.7 7.5 1.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 ERZ96910.1 - 0.00047 20.3 22.7 0.0052 16.9 7.9 3.5 2 2 2 4 4 4 2 Multidrug resistance efflux transporter TPT PF03151.11 ERZ96910.1 - 0.0012 18.5 9.6 0.0012 18.5 6.7 3.2 3 0 0 3 3 3 1 Triose-phosphate Transporter family Malate_synthase PF01274.17 ERZ96911.1 - 2.3e-224 745.2 0.0 2.6e-224 745.0 0.0 1.0 1 0 0 1 1 1 1 Malate synthase PH_10 PF15411.1 ERZ96912.1 - 2.2e-42 143.9 2.3 2.9e-42 143.5 0.5 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.15 ERZ96912.1 - 2.2e-40 138.4 2.9 2.2e-40 138.4 2.0 2.4 3 0 0 3 3 3 1 RhoGEF domain CDC24 PF06395.6 ERZ96912.1 - 3.6e-28 97.4 0.1 9e-28 96.1 0.0 1.7 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.19 ERZ96912.1 - 5e-16 58.1 0.5 1.4e-15 56.7 0.0 2.1 2 0 0 2 2 2 1 PB1 domain PH PF00169.24 ERZ96912.1 - 0.0017 18.5 0.7 0.0059 16.7 0.5 2.0 1 0 0 1 1 1 1 PH domain TerD PF02342.13 ERZ96913.1 - 1e-10 41.2 0.0 1.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ96913.1 - 2.8e-06 26.6 0.2 9.3e-06 24.9 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ96913.1 - 0.0046 16.6 0.1 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TerD PF02342.13 ERZ96914.1 - 2e-12 46.8 0.0 3.6e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ERZ96914.1 - 5.6e-06 25.6 1.5 1.7e-05 24.1 1.0 1.8 1 1 0 1 1 1 1 Ubiquitin family Pkinase PF00069.20 ERZ96918.1 - 8.4e-38 129.9 0.0 1e-37 129.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96918.1 - 2.3e-33 115.3 0.0 2.7e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ96918.1 - 0.00017 21.4 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ96918.1 - 0.0026 16.7 0.0 0.0033 16.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ERZ96918.1 - 0.0027 17.0 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ96918.1 - 0.018 14.1 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ERZ96918.1 - 0.027 13.6 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Seadorna_VP7 PF07387.6 ERZ96918.1 - 0.035 12.9 0.1 0.12 11.1 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 Choline_kinase PF01633.15 ERZ96918.1 - 0.065 12.7 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Methyltransf_7 PF03492.10 ERZ96918.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Cytochrom_B558a PF05038.8 ERZ96922.1 - 0.082 12.5 0.1 0.088 12.4 0.1 1.1 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit DUF3194 PF11419.3 ERZ96923.1 - 0.064 13.4 0.6 0.08 13.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) Peptidase_U40 PF10464.4 ERZ96923.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 1 0 1 1 1 0 Peptidase U40 UCH PF00443.24 ERZ96924.1 - 1.5e-55 188.2 5.2 1.9e-55 187.8 3.6 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ERZ96924.1 - 2e-32 112.8 0.1 2.8e-32 112.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 ERZ96924.1 - 2.2e-10 40.8 0.2 8.5e-09 35.6 0.0 2.8 1 1 1 2 2 2 1 MATH domain Uma2 PF05685.7 ERZ96928.1 - 0.00081 18.7 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease PQ-loop PF04193.9 ERZ96932.1 - 3.6e-35 119.3 26.9 2.3e-19 68.6 1.7 3.7 3 1 0 3 3 3 2 PQ loop repeat Herpes_LMP1 PF05297.6 ERZ96932.1 - 0.00062 18.7 8.6 0.00091 18.2 6.0 1.2 1 0 0 1 1 1 1 Herpesvirus latent membrane protein 1 (LMP1) CFEM PF05730.6 ERZ96933.1 - 0.025 14.3 8.4 0.066 13.0 5.8 1.7 1 1 0 1 1 1 0 CFEM domain ETRAMP PF09716.5 ERZ96933.1 - 0.058 13.3 0.0 0.31 11.0 0.0 2.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TMEM154 PF15102.1 ERZ96933.1 - 0.13 11.9 2.1 0.18 11.4 1.5 1.3 1 0 0 1 1 1 0 TMEM154 protein family MCPVI PF02993.9 ERZ96933.1 - 0.7 9.9 4.1 13 5.8 3.9 1.8 2 0 0 2 2 2 0 Minor capsid protein VI ABC_tran PF00005.22 ERZ96935.1 - 2.3e-45 154.2 0.0 2.4e-21 76.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_tran_2 PF12848.2 ERZ96935.1 - 9e-20 70.3 3.5 9e-20 70.3 2.5 2.8 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.1 ERZ96935.1 - 1.2e-19 71.3 11.7 1e-05 25.6 3.7 4.3 2 2 1 3 3 3 3 AAA domain AAA_29 PF13555.1 ERZ96935.1 - 3e-09 36.2 0.1 0.0033 16.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 ERZ96935.1 - 9.8e-09 34.7 3.6 0.28 10.3 0.0 4.5 5 0 0 5 5 5 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ERZ96935.1 - 5.1e-08 33.7 0.0 0.0059 17.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 ERZ96935.1 - 7.6e-08 32.8 0.0 0.038 14.4 0.0 3.3 3 0 0 3 3 3 2 Miro-like protein AAA_23 PF13476.1 ERZ96935.1 - 1.9e-06 28.3 6.7 0.16 12.2 0.0 4.0 4 0 0 4 4 3 2 AAA domain AAA_33 PF13671.1 ERZ96935.1 - 2.6e-06 27.3 0.0 0.023 14.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ERZ96935.1 - 7.5e-06 26.1 0.1 0.12 12.4 0.0 3.0 2 2 0 2 2 2 2 AAA domain NACHT PF05729.7 ERZ96935.1 - 9.8e-06 25.3 0.0 0.061 12.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.1 ERZ96935.1 - 1.1e-05 24.8 0.0 0.15 11.4 0.0 3.1 2 1 0 2 2 2 2 AAA domain DUF258 PF03193.11 ERZ96935.1 - 2.2e-05 23.7 0.0 0.0045 16.1 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 ERZ96935.1 - 3.4e-05 23.0 3.4 3 6.7 0.0 4.5 2 1 3 5 5 5 2 AAA ATPase domain MMR_HSR1 PF01926.18 ERZ96935.1 - 3.6e-05 23.6 1.7 0.075 12.9 0.1 3.6 4 1 0 4 4 2 2 50S ribosome-binding GTPase AAA_28 PF13521.1 ERZ96935.1 - 5.6e-05 23.1 0.0 0.11 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 ERZ96935.1 - 6.4e-05 22.8 0.0 0.67 9.8 0.0 3.6 2 1 0 3 3 3 2 AAA domain AAA_18 PF13238.1 ERZ96935.1 - 0.00014 22.1 0.3 0.48 10.7 0.0 3.1 3 1 0 3 3 2 2 AAA domain MobB PF03205.9 ERZ96935.1 - 0.00017 21.3 0.0 0.12 12.0 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ERZ96935.1 - 0.0002 20.9 0.3 0.28 10.5 0.0 3.0 3 0 0 3 3 3 1 AAA-like domain RNA_helicase PF00910.17 ERZ96935.1 - 0.0002 21.4 0.0 0.54 10.4 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.1 ERZ96935.1 - 0.00024 21.1 0.1 0.42 10.5 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain Dynamin_N PF00350.18 ERZ96935.1 - 0.00025 20.9 0.4 1.8 8.3 0.0 3.8 4 0 0 4 4 4 1 Dynamin family AAA PF00004.24 ERZ96935.1 - 0.00046 20.4 0.0 0.075 13.2 0.0 3.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.12 ERZ96935.1 - 0.00095 19.0 0.0 2.3 7.9 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function DUF87 SbcCD_C PF13558.1 ERZ96935.1 - 0.0026 17.6 0.1 0.8 9.6 0.0 2.8 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.9 ERZ96935.1 - 0.0026 17.4 0.0 1.4 8.6 0.1 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.13 ERZ96935.1 - 0.0034 16.8 0.0 0.11 12.0 0.0 2.5 3 0 0 3 3 3 1 FtsK/SpoIIIE family Arch_ATPase PF01637.13 ERZ96935.1 - 0.0067 16.1 0.6 3.3 7.3 0.0 3.2 3 0 0 3 3 3 1 Archaeal ATPase ATP_bind_1 PF03029.12 ERZ96935.1 - 0.0095 15.4 0.0 5.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.17 ERZ96935.1 - 0.0097 14.7 0.0 0.72 8.6 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain SRP54 PF00448.17 ERZ96935.1 - 0.0098 15.3 0.8 2.1 7.7 0.0 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.1 ERZ96935.1 - 0.012 15.6 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DAP3 PF10236.4 ERZ96935.1 - 0.018 14.0 1.5 2.8 6.8 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 T2SE PF00437.15 ERZ96935.1 - 0.028 13.3 0.0 1.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein ArgK PF03308.11 ERZ96935.1 - 0.038 12.7 0.2 6.4 5.4 0.0 2.6 3 0 0 3 3 2 0 ArgK protein DUF815 PF05673.8 ERZ96935.1 - 0.047 12.6 0.1 1.3 7.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF815) NTPase_1 PF03266.10 ERZ96935.1 - 0.056 13.1 0.0 1.3 8.6 0.0 2.8 2 0 0 2 2 2 0 NTPase TnpV PF14198.1 ERZ96935.1 - 0.071 12.9 2.0 0.095 12.5 0.3 1.9 2 0 0 2 2 1 0 Transposon-encoded protein TnpV VirE PF05272.6 ERZ96935.1 - 0.072 12.5 1.1 9.1 5.7 0.0 3.2 3 0 0 3 3 3 0 Virulence-associated protein E DegQ PF08181.6 ERZ96937.1 - 0.021 14.5 0.4 0.03 14.0 0.3 1.2 1 0 0 1 1 1 0 DegQ (SacQ) family Diacid_rec PF05651.8 ERZ96937.1 - 0.13 11.6 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative sugar diacid recognition Pkinase PF00069.20 ERZ96939.1 - 0.014 14.5 0.0 0.031 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein kinase domain Voltage_CLC PF00654.15 ERZ96943.1 - 2.3e-90 303.1 18.5 2.3e-90 303.1 12.8 2.1 3 0 0 3 3 3 1 Voltage gated chloride channel CBS PF00571.23 ERZ96943.1 - 1.2e-09 37.7 0.1 2.7e-07 30.2 0.0 2.7 2 0 0 2 2 2 2 CBS domain p450 PF00067.17 ERZ96944.1 - 3.1e-68 230.3 1.6 1.2e-57 195.5 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 FANCI_HD1 PF14679.1 ERZ96944.1 - 0.093 12.4 0.0 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 FANCI helical domain 1 zf-PARP PF00645.13 ERZ96946.1 - 0.0051 17.0 3.4 0.072 13.3 1.1 2.4 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region TENA_THI-4 PF03070.11 ERZ96946.1 - 0.01 15.5 0.9 0.048 13.4 0.0 2.0 2 0 0 2 2 2 0 TENA/THI-4/PQQC family Ribosomal_S13 PF00416.17 ERZ96946.1 - 3.2 8.2 7.5 0.76 10.2 0.2 2.3 2 0 0 2 2 2 0 Ribosomal protein S13/S18 SPRY PF00622.23 ERZ96947.1 - 4.2e-12 46.2 0.4 7.6e-12 45.3 0.3 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ96947.1 - 1.6e-06 28.0 4.4 0.00014 21.8 0.3 2.6 2 0 0 2 2 2 2 BTB/POZ domain CAGE1 PF15066.1 ERZ96947.1 - 0.0048 15.3 0.3 0.007 14.8 0.2 1.1 1 0 0 1 1 1 1 Cancer-associated gene protein 1 family RAG2_PHD PF13341.1 ERZ96947.1 - 0.094 12.7 1.0 0.22 11.4 0.7 1.6 1 0 0 1 1 1 0 RAG2 PHD domain BTB PF00651.26 ERZ96948.1 - 1.2e-21 76.7 0.1 2.7e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ERZ96948.1 - 6.6e-13 48.8 0.4 1.4e-12 47.7 0.3 1.5 1 0 0 1 1 1 1 SPRY domain DASH_Dad1 PF08649.5 ERZ96949.1 - 0.095 12.4 0.5 0.095 12.4 0.3 2.2 2 1 0 2 2 2 0 DASH complex subunit Dad1 CSTF_C PF14304.1 ERZ96950.1 - 0.019 14.2 0.1 0.073 12.3 0.0 2.0 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal DUF1892 PF08987.5 ERZ96950.1 - 0.37 10.8 2.7 6.2 6.8 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1892) BTB_2 PF02214.17 ERZ96951.1 - 9e-09 35.4 0.0 2e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain CH PF00307.26 ERZ96952.1 - 0.055 13.5 0.3 0.9 9.6 0.0 3.0 4 1 0 4 4 4 0 Calponin homology (CH) domain DUF4206 PF13901.1 ERZ96952.1 - 0.33 10.4 1.0 3.4 7.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4206) RRM_1 PF00076.17 ERZ96953.1 - 0.063 12.9 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 ERZ96955.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain DUF2414 PF10309.4 ERZ96955.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) 7TM_transglut PF14402.1 ERZ96957.1 - 0.087 11.7 0.0 0.098 11.5 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DDE_1 PF03184.14 ERZ96959.1 - 1.8e-14 53.4 0.2 5.3e-14 51.8 0.1 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 ERZ96960.1 - 6.9e-19 67.8 1.4 2.6e-13 49.6 0.3 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ96960.1 - 2.8e-12 46.2 0.0 6.5e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain APT PF03440.9 ERZ96960.1 - 0.08 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Aerolysin/Pertussis toxin (APT) domain DDE_1 PF03184.14 ERZ96962.1 - 6.3e-39 133.3 1.4 7.9e-39 133.0 1.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ERZ96962.1 - 0.00084 19.1 0.2 0.002 17.9 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Phasin PF05597.6 ERZ96963.1 - 0.051 13.3 0.4 0.12 12.1 0.3 1.6 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PAT1 PF09770.4 ERZ96963.1 - 0.74 7.9 24.4 1.1 7.4 16.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NIF PF03031.13 ERZ96964.1 - 9.6e-18 64.3 0.6 2.2e-17 63.1 0.4 1.5 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Myb_DNA-bind_6 PF13921.1 ERZ96965.1 - 2.8e-17 62.5 14.1 3.7e-09 36.5 2.0 3.1 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ERZ96965.1 - 4.6e-16 58.6 7.5 4.1e-10 39.5 0.3 3.2 3 0 0 3 3 3 3 Myb-like DNA-binding domain HTH_38 PF13936.1 ERZ96965.1 - 0.00091 18.7 0.1 1.8 8.1 0.0 2.8 3 1 0 3 3 3 2 Helix-turn-helix domain HTH_23 PF13384.1 ERZ96965.1 - 0.0018 17.8 0.0 2 8.1 0.0 2.5 2 0 0 2 2 2 2 Homeodomain-like domain Sigma70_r4_2 PF08281.7 ERZ96965.1 - 0.008 15.6 0.1 0.45 10.0 0.0 2.4 3 0 0 3 3 3 1 Sigma-70, region 4 CPSase_L_D3 PF02787.14 ERZ96965.1 - 0.019 14.7 1.9 0.13 12.0 0.3 2.1 1 1 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain GerE PF00196.14 ERZ96965.1 - 0.056 12.7 0.0 9.7 5.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Glyco_trans_1_2 PF13524.1 ERZ96965.1 - 0.084 13.1 0.2 0.16 12.2 0.1 1.6 1 1 0 1 1 1 0 Glycosyl transferases group 1 DUF4378 PF14309.1 ERZ96965.1 - 0.1 12.6 3.7 0.34 10.9 2.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4378) TarH PF02203.10 ERZ96965.1 - 0.12 12.1 1.6 1.3 8.8 0.0 2.0 1 1 1 2 2 2 0 Tar ligand binding domain homologue Atg14 PF10186.4 ERZ96965.1 - 0.15 10.9 3.8 0.18 10.7 2.6 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Syntaxin_2 PF14523.1 ERZ96965.1 - 0.18 11.8 7.1 12 5.9 2.2 2.9 1 1 1 2 2 2 0 Syntaxin-like protein NusB PF01029.13 ERZ96965.1 - 0.65 9.9 3.7 10 6.1 0.5 2.1 1 1 1 2 2 2 0 NusB family DUP PF00674.13 ERZ96965.1 - 0.87 9.5 5.7 4.3 7.3 0.6 2.4 1 1 0 2 2 2 0 DUP family Mor PF08765.6 ERZ96965.1 - 2.1 8.1 5.0 3.1 7.6 0.9 2.1 2 0 0 2 2 2 0 Mor transcription activator family BTB PF00651.26 ERZ96966.1 - 2.6e-16 59.5 0.2 1.2e-15 57.4 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ96966.1 - 1.2e-09 38.2 2.2 5.1e-09 36.2 0.6 2.6 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ96966.1 - 2.6e-07 30.3 2.2 1e-05 25.2 0.4 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch HHH_7 PF14635.1 ERZ96967.1 - 0.0066 16.5 1.9 0.014 15.4 0.0 2.6 3 1 0 3 3 3 1 Helix-hairpin-helix motif AAA PF00004.24 ERZ96969.1 - 9.7e-07 29.0 0.0 0.001 19.2 0.0 4.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ96969.1 - 3.9e-05 23.3 0.0 0.0055 16.4 0.0 3.4 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ERZ96969.1 - 0.00024 21.0 0.3 0.0022 17.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ERZ96969.1 - 0.0018 18.4 0.3 0.13 12.3 0.0 4.0 4 1 1 5 5 5 1 AAA domain Miro PF08477.8 ERZ96969.1 - 0.032 14.7 0.0 0.13 12.7 0.0 2.1 1 0 0 1 1 1 0 Miro-like protein Sigma54_activ_2 PF14532.1 ERZ96969.1 - 0.04 13.9 0.0 2.2 8.3 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.7 ERZ96969.1 - 0.057 13.0 0.0 0.46 10.1 0.0 2.7 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.1 ERZ96969.1 - 0.15 12.0 0.0 1.7 8.5 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain Pkinase PF00069.20 ERZ96970.1 - 8.5e-22 77.5 1.1 9.6e-22 77.3 0.8 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ96970.1 - 1.1e-20 73.8 0.0 1.2e-20 73.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ERZ96970.1 - 0.027 13.8 0.1 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL HSP70 PF00012.15 ERZ96971.1 - 8.7e-197 654.7 0.2 1e-196 654.4 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ96971.1 - 2e-11 43.0 1.2 2.9e-10 39.2 0.3 2.3 2 1 0 2 2 2 1 MreB/Mbl protein DDR PF08841.5 ERZ96971.1 - 0.025 13.4 0.3 0.88 8.3 0.1 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain NYN PF01936.13 ERZ96972.1 - 0.017 15.4 0.0 0.039 14.2 0.0 1.5 1 1 0 1 1 1 0 NYN domain GTF2I PF02946.9 ERZ96973.1 - 0.003 17.3 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 GTF2I-like repeat UPF0081 PF03652.10 ERZ96973.1 - 0.08 13.0 1.0 0.26 11.4 0.0 2.4 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0081) DUF4250 PF14056.1 ERZ96973.1 - 0.1 12.3 1.9 14 5.4 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Syntaxin_2 PF14523.1 ERZ96973.1 - 5.8 6.9 11.7 4.4 7.3 0.4 3.1 3 0 0 3 3 3 0 Syntaxin-like protein DUF2457 PF10446.4 ERZ96974.1 - 0.036 12.8 8.5 0.031 12.9 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.5 ERZ96974.1 - 0.13 12.4 7.8 0.24 11.6 5.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ATG27 PF09451.5 ERZ96974.1 - 0.22 10.7 5.7 0.31 10.2 3.9 1.3 1 1 0 1 1 1 0 Autophagy-related protein 27 DUF4611 PF15387.1 ERZ96974.1 - 0.28 11.3 7.6 0.12 12.5 3.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Sigma70_ner PF04546.8 ERZ96974.1 - 0.51 9.9 3.3 0.73 9.4 2.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Osteopontin PF00865.13 ERZ96974.1 - 0.59 9.3 11.4 0.81 8.8 7.9 1.2 1 0 0 1 1 1 0 Osteopontin NOA36 PF06524.7 ERZ96974.1 - 1.3 8.2 14.3 0.63 9.2 8.2 1.5 1 1 1 2 2 2 0 NOA36 protein Minor_capsid_3 PF12691.2 ERZ96975.1 - 0.098 12.3 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage LRR_4 PF12799.2 ERZ96979.1 - 1.2 8.7 17.1 0.48 10.1 0.3 4.8 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_2 PF07723.8 ERZ96980.1 - 0.16 12.4 4.2 2.6 8.7 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat p450 PF00067.17 ERZ96981.1 - 7.4e-43 146.7 0.3 8.3e-43 146.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 RRM_1 PF00076.17 ERZ96982.1 - 0.00068 19.2 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ERZ96983.1 - 0.00064 19.3 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ96983.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Rubella_Capsid PF05750.6 ERZ96983.1 - 0.19 11.1 6.9 0.25 10.6 4.8 1.1 1 0 0 1 1 1 0 Rubella capsid protein Macoilin PF09726.4 ERZ96983.1 - 0.36 9.0 13.4 0.42 8.8 9.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Hid1 PF12722.2 ERZ96983.1 - 0.61 7.7 12.6 0.74 7.4 8.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NST1 PF13945.1 ERZ96983.1 - 2.7 8.0 12.7 5 7.1 8.8 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator MIP-T3 PF10243.4 ERZ96983.1 - 3.3 6.0 18.5 4.5 5.6 12.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Spo0M PF07070.6 ERZ96986.1 - 0.04 13.2 0.0 0.055 12.7 0.0 1.2 1 0 0 1 1 1 0 SpoOM protein Frigida PF07899.6 ERZ96986.1 - 0.068 11.9 0.2 0.076 11.7 0.2 1.2 1 0 0 1 1 1 0 Frigida-like protein zf-CCHC PF00098.18 ERZ96987.1 - 0.0062 16.4 3.9 0.01 15.7 2.7 1.3 1 0 0 1 1 1 1 Zinc knuckle Vac_Fusion PF02346.11 ERZ96987.1 - 0.0077 15.6 0.4 0.31 10.4 0.1 2.6 2 0 0 2 2 2 1 Chordopoxvirus fusion protein gag-asp_proteas PF13975.1 ERZ96987.1 - 0.042 13.6 0.1 18 5.2 0.1 3.4 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.5 ERZ96987.1 - 0.1 12.1 0.1 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease IncA PF04156.9 ERZ96987.1 - 2.3 7.7 5.3 5.1 6.6 0.5 2.8 1 1 1 2 2 2 0 IncA protein Occludin_ELL PF07303.8 ERZ96987.1 - 3.3 8.4 8.3 8.6 7.1 0.1 3.1 3 0 0 3 3 3 0 Occludin homology domain AAA_13 PF13166.1 ERZ96988.1 - 0.00042 18.9 14.6 0.00063 18.3 10.1 1.3 1 1 0 1 1 1 1 AAA domain FliJ PF02050.11 ERZ96988.1 - 0.00049 20.1 9.1 0.23 11.5 2.9 3.3 2 1 1 3 3 3 1 Flagellar FliJ protein Laminin_I PF06008.9 ERZ96988.1 - 0.0014 17.9 10.3 0.0056 16.0 7.1 2.4 1 1 0 1 1 1 1 Laminin Domain I CENP-F_leu_zip PF10473.4 ERZ96988.1 - 0.0026 17.6 11.2 0.44 10.3 0.1 2.4 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 ERZ96988.1 - 0.0028 16.9 1.4 1.1 8.3 0.1 2.1 2 0 0 2 2 2 2 Reovirus sigma C capsid protein PspA_IM30 PF04012.7 ERZ96988.1 - 0.0029 17.0 1.4 0.17 11.2 0.2 2.6 1 1 1 2 2 2 1 PspA/IM30 family HAUS6_N PF14661.1 ERZ96988.1 - 0.0032 16.8 5.6 0.2 10.9 2.1 2.1 1 1 1 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus Peptidase_S46 PF10459.4 ERZ96988.1 - 0.0083 14.5 3.2 0.009 14.4 2.2 1.1 1 0 0 1 1 1 1 Peptidase S46 ATG16 PF08614.6 ERZ96988.1 - 0.015 15.0 6.7 0.015 15.0 4.6 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.7 ERZ96988.1 - 0.028 14.1 2.0 0.028 14.1 1.4 5.2 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat DOG1 PF14144.1 ERZ96988.1 - 0.03 14.3 1.2 7.3 6.7 0.0 2.8 3 0 0 3 3 2 0 Seed dormancy control Shugoshin_N PF07558.6 ERZ96988.1 - 0.035 13.8 1.6 0.035 13.8 1.1 2.5 3 0 0 3 3 1 0 Shugoshin N-terminal coiled-coil region Fib_alpha PF08702.5 ERZ96988.1 - 0.041 13.9 17.8 0.23 11.5 5.3 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family CCDC155 PF14662.1 ERZ96988.1 - 0.055 13.0 1.0 0.055 13.0 0.7 3.0 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 CENP-Q PF13094.1 ERZ96988.1 - 0.069 13.1 8.4 0.09 12.7 4.9 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF948 PF06103.6 ERZ96988.1 - 0.086 12.7 6.3 3.8 7.4 0.4 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4200 PF13863.1 ERZ96988.1 - 0.095 12.6 12.3 2.4 8.0 7.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Tup_N PF08581.5 ERZ96988.1 - 0.1 12.7 8.7 0.41 10.8 2.4 2.9 2 1 0 2 2 2 0 Tup N-terminal COG5 PF10392.4 ERZ96988.1 - 0.11 12.4 6.6 7 6.6 0.0 2.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF3373 PF11853.3 ERZ96988.1 - 0.12 10.9 1.7 0.15 10.5 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF1664 PF07889.7 ERZ96988.1 - 0.12 12.1 9.8 3.9 7.2 0.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Vps51 PF08700.6 ERZ96988.1 - 0.12 12.2 7.7 2.9 7.7 0.2 3.5 3 0 0 3 3 3 0 Vps51/Vps67 Syntaxin PF00804.20 ERZ96988.1 - 0.12 12.5 16.4 1.4 9.1 4.6 3.2 1 1 2 3 3 3 0 Syntaxin DUF677 PF05055.7 ERZ96988.1 - 0.12 10.9 7.2 0.12 11.0 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF677) DUF2630 PF10944.3 ERZ96988.1 - 0.14 12.2 0.5 0.14 12.2 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) Baculo_PEP_C PF04513.7 ERZ96988.1 - 0.2 11.4 15.6 0.17 11.7 2.1 2.8 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 ERZ96988.1 - 0.25 10.9 21.2 2.9 7.4 6.9 3.0 1 1 1 2 2 2 0 IncA protein APG6 PF04111.7 ERZ96988.1 - 0.28 10.2 13.4 0.64 9.0 6.3 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 FlaC_arch PF05377.6 ERZ96988.1 - 0.28 11.0 14.0 0.29 11.0 0.9 4.5 4 2 1 5 5 4 0 Flagella accessory protein C (FlaC) Raptor_N PF14538.1 ERZ96988.1 - 0.33 10.7 3.5 1.2 8.9 0.4 2.5 2 1 1 3 3 3 0 Raptor N-terminal CASPase like domain TMF_DNA_bd PF12329.3 ERZ96988.1 - 0.38 10.5 10.9 0.73 9.6 4.8 3.3 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding NPV_P10 PF05531.7 ERZ96988.1 - 0.39 10.9 9.4 0.41 10.9 0.8 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein V_ATPase_I PF01496.14 ERZ96988.1 - 0.41 8.4 11.8 0.78 7.5 8.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.7 ERZ96988.1 - 0.46 10.2 11.3 1.2 8.8 1.9 2.6 1 1 2 3 3 3 0 Laminin Domain II CENP-H PF05837.7 ERZ96988.1 - 0.58 10.3 13.4 0.17 12.0 4.4 2.8 2 1 0 2 2 2 0 Centromere protein H (CENP-H) THOC7 PF05615.8 ERZ96988.1 - 0.6 10.3 12.9 1.4 9.1 4.6 3.2 2 2 0 2 2 2 0 Tho complex subunit 7 COG2 PF06148.6 ERZ96988.1 - 0.6 9.9 8.7 0.9 9.4 0.1 3.1 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Snf7 PF03357.16 ERZ96988.1 - 0.77 9.1 11.8 0.17 11.2 4.7 2.1 1 1 0 2 2 2 0 Snf7 TMPIT PF07851.8 ERZ96988.1 - 1.2 8.0 8.5 9.3 5.2 3.7 2.2 1 1 0 2 2 2 0 TMPIT-like protein DUF4140 PF13600.1 ERZ96988.1 - 1.4 9.4 8.3 1.7 9.1 1.2 3.5 2 2 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) RasGAP_C PF03836.10 ERZ96988.1 - 1.6 8.4 12.2 2.9 7.5 5.0 2.2 2 0 0 2 2 2 0 RasGAP C-terminus DUF972 PF06156.8 ERZ96988.1 - 2.2 8.6 12.4 0.55 10.6 2.3 3.3 1 1 2 4 4 4 0 Protein of unknown function (DUF972) Atg14 PF10186.4 ERZ96988.1 - 2.2 7.1 19.3 0.23 10.3 7.9 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 SlyX PF04102.7 ERZ96988.1 - 2.6 8.5 7.1 0.65 10.4 1.0 2.9 3 1 0 3 3 1 0 SlyX DUF4315 PF14193.1 ERZ96988.1 - 2.8 7.9 8.1 1.1 9.1 1.1 2.9 3 1 0 4 4 2 0 Domain of unknown function (DUF4315) FlxA PF14282.1 ERZ96988.1 - 3.1 7.7 12.6 0.14 12.0 2.5 2.5 2 2 0 2 2 2 0 FlxA-like protein CCDC-167 PF15188.1 ERZ96988.1 - 3.4 7.6 9.0 7.7 6.5 4.6 2.9 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF2681 PF10883.3 ERZ96988.1 - 3.9 7.7 7.9 0.61 10.3 2.0 2.3 2 2 0 2 2 1 0 Protein of unknown function (DUF2681) Med9 PF07544.8 ERZ96988.1 - 4.5 7.0 12.2 0.069 12.8 1.5 3.0 4 1 0 4 4 2 0 RNA polymerase II transcription mediator complex subunit 9 Lzipper-MIP1 PF14389.1 ERZ96988.1 - 4.7 7.3 10.2 1.7 8.8 4.2 2.3 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 ADIP PF11559.3 ERZ96988.1 - 5 7.0 17.6 8.2 6.3 5.6 2.6 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding HR1 PF02185.11 ERZ96988.1 - 5.1 6.8 19.4 1.7 8.4 1.3 4.2 2 2 2 4 4 4 0 Hr1 repeat DUF869 PF05911.6 ERZ96988.1 - 5.2 5.1 12.6 11 4.0 0.1 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) TPR_MLP1_2 PF07926.7 ERZ96988.1 - 5.5 6.7 13.7 21 4.8 9.5 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Rabaptin PF03528.10 ERZ96988.1 - 5.5 6.9 9.3 4.2 7.3 2.3 2.6 2 2 0 2 2 2 0 Rabaptin DUF4404 PF14357.1 ERZ96988.1 - 5.6 7.4 16.5 1.7 9.0 1.9 4.0 2 2 3 5 5 5 0 Domain of unknown function (DUF4404) GP41 PF00517.12 ERZ96988.1 - 6.3 6.3 9.3 3 7.3 0.7 2.7 2 1 0 2 2 2 0 Retroviral envelope protein TSC22 PF01166.13 ERZ96988.1 - 6.4 6.8 7.6 1.3 9.0 0.4 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF641 PF04859.7 ERZ96988.1 - 6.4 6.5 9.4 24 4.6 3.4 2.9 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF3571 PF12095.3 ERZ96988.1 - 6.8 7.0 7.8 7.4 6.8 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3571) TBPIP PF07106.8 ERZ96988.1 - 7.4 6.0 16.1 0.49 9.9 2.5 2.9 1 1 3 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF1640 PF07798.6 ERZ96988.1 - 9.6 6.2 12.2 34 4.4 7.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) ATG16 PF08614.6 ERZ96989.1 - 0.00055 19.8 0.3 0.00077 19.3 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Med2 PF11214.3 ERZ96989.1 - 0.052 13.5 1.2 0.11 12.5 0.9 1.7 1 1 0 1 1 1 0 Mediator complex subunit 2 Cep57_CLD PF14073.1 ERZ96989.1 - 0.079 12.7 2.0 0.37 10.5 1.4 1.9 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 NPV_P10 PF05531.7 ERZ96989.1 - 0.083 13.1 0.3 0.13 12.5 0.2 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 ERZ96989.1 - 0.089 12.5 0.8 0.13 12.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 ERZ96989.1 - 0.12 12.5 0.9 0.18 11.9 0.6 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Rieske PF00355.21 ERZ96989.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain TMF_DNA_bd PF12329.3 ERZ96989.1 - 1.9 8.3 6.3 2.5 7.9 1.0 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Bac_DnaA PF00308.13 ERZ96992.1 - 0.00046 19.9 0.0 0.001 18.7 0.0 1.7 1 0 0 1 1 1 1 Bacterial dnaA protein Arch_ATPase PF01637.13 ERZ96992.1 - 0.0081 15.8 0.0 0.026 14.2 0.0 1.7 1 1 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 ERZ96992.1 - 0.0092 15.6 0.0 0.034 13.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.12 ERZ96992.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP_bind_1 PF03029.12 ERZ96992.1 - 0.16 11.4 2.8 0.67 9.4 0.5 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Bac_DnaA PF00308.13 ERZ96993.1 - 2.5e-05 24.0 0.0 3.1e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial dnaA protein IstB_IS21 PF01695.12 ERZ96993.1 - 0.0047 16.3 0.0 0.0055 16.1 0.0 1.1 1 0 0 1 1 1 1 IstB-like ATP binding protein Arch_ATPase PF01637.13 ERZ96993.1 - 0.024 14.3 0.0 0.029 14.0 0.0 1.1 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 ERZ96993.1 - 0.099 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Phage_min_cap2 PF06152.6 ERZ96994.1 - 0.039 12.9 0.1 0.048 12.6 0.1 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 Amidohydro_1 PF01979.15 ERZ96997.1 - 1.2e-14 54.7 0.0 1.5e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 ERZ96997.1 - 1.7e-12 47.9 0.0 2.5e-12 47.4 0.0 1.3 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ERZ96997.1 - 2e-05 23.9 0.0 2.6e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family DUF659 PF04937.10 ERZ96998.1 - 9.7e-15 54.3 2.0 1.1e-13 51.0 0.4 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF 659) zf-BED PF02892.10 ERZ96998.1 - 3.6e-05 23.4 0.0 8.7e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 BED zinc finger DUF4379 PF14311.1 ERZ97001.1 - 8.6e-12 44.6 61.1 0.00079 19.1 2.0 6.3 6 0 0 6 6 6 6 Domain of unknown function (DUF4379) Galactosyl_T PF01762.16 ERZ97001.1 - 0.014 15.0 0.8 17 4.9 0.0 3.9 2 1 2 4 4 4 0 Galactosyltransferase PepSY PF03413.14 ERZ97001.1 - 0.036 14.7 0.0 35 5.1 0.0 3.6 4 0 0 4 4 4 0 Peptidase propeptide and YPEB domain Thioredoxin_7 PF13899.1 ERZ97001.1 - 2.4 8.2 12.5 12 5.9 0.0 5.4 7 0 0 7 7 7 0 Thioredoxin-like DUF953 PF06110.6 ERZ97001.1 - 4.8 6.6 28.3 4.1 6.8 0.1 6.0 3 1 1 6 6 6 0 Eukaryotic protein of unknown function (DUF953) Cys_rich_CPXG PF14255.1 ERZ97001.1 - 8.4 6.3 20.1 17 5.3 0.2 6.3 7 0 0 7 7 7 0 Cysteine-rich CPXCG GTA_TIM PF13547.1 ERZ97003.1 - 0.0045 16.0 0.1 0.0056 15.7 0.1 1.1 1 0 0 1 1 1 1 GTA TIM-barrel-like domain Rubella_Capsid PF05750.6 ERZ97004.1 - 0.016 14.6 1.5 0.019 14.4 1.0 1.0 1 0 0 1 1 1 0 Rubella capsid protein Spore_coat_CotO PF14153.1 ERZ97004.1 - 0.44 9.9 6.2 0.55 9.6 4.3 1.3 1 0 0 1 1 1 0 Spore coat protein CotO MIP-T3 PF10243.4 ERZ97004.1 - 0.45 8.9 14.9 0.56 8.6 10.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Macoilin PF09726.4 ERZ97004.1 - 0.94 7.6 17.0 1.1 7.4 11.8 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_S64 PF08192.6 ERZ97004.1 - 1 7.6 11.2 1.1 7.4 7.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF605 PF04652.11 ERZ97004.1 - 1.6 8.0 13.6 1.8 7.8 9.4 1.1 1 0 0 1 1 1 0 Vta1 like Gag_spuma PF03276.9 ERZ97004.1 - 2.8 6.1 13.1 3.1 5.9 9.1 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Lin-8 PF03353.10 ERZ97004.1 - 3.6 6.7 10.6 4 6.6 7.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.5 ERZ97004.1 - 4.8 5.4 12.4 5.6 5.2 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.9 ERZ97004.1 - 5.5 6.6 8.5 6.6 6.3 5.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RRM_1 PF00076.17 ERZ97005.1 - 1.9e-07 30.5 0.0 5.6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ97005.1 - 0.00024 21.0 0.0 0.0034 17.3 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ97005.1 - 0.1 12.4 0.0 0.62 9.9 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF773 PF05600.7 ERZ97006.1 - 0.022 13.5 0.9 0.025 13.3 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF773) FPN1 PF06963.7 ERZ97006.1 - 0.064 11.6 0.2 0.064 11.6 0.1 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) E7 PF00527.13 ERZ97006.1 - 0.092 12.9 0.3 0.13 12.4 0.2 1.3 1 0 0 1 1 1 0 E7 protein, Early protein EST1 PF10374.4 ERZ97006.1 - 0.21 11.5 5.3 0.29 11.1 3.7 1.1 1 0 0 1 1 1 0 Telomerase activating protein Est1 E1_DerP2_DerF2 PF02221.10 ERZ97007.1 - 4.2e-09 36.7 0.5 6e-09 36.2 0.3 1.2 1 0 0 1 1 1 1 ML domain GST_C PF00043.20 ERZ97008.1 - 2.5e-13 49.8 0.1 4.7e-13 48.9 0.0 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ERZ97008.1 - 4.8e-12 45.9 0.0 8.2e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ERZ97008.1 - 7.5e-11 42.0 0.0 1.6e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ERZ97008.1 - 1.7e-07 31.0 0.0 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ERZ97008.1 - 2.7e-06 27.2 0.0 4.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MetRS-N PF09635.5 ERZ97008.1 - 0.067 13.5 0.1 0.18 12.1 0.0 1.7 1 1 1 2 2 2 0 MetRS-N binding domain GST_N_3 PF13417.1 ERZ97009.1 - 7.3e-14 51.7 0.0 1.1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ERZ97009.1 - 3.3e-09 36.8 0.0 4.8e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ERZ97009.1 - 6e-08 32.5 0.0 8.7e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Nsp1_C PF05064.8 ERZ97009.1 - 0.041 13.5 0.1 0.059 13.0 0.1 1.2 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF1509 PF07420.6 ERZ97013.1 - 0.15 11.3 6.0 0.17 11.1 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Herpes_UL56 PF04534.7 ERZ97013.1 - 0.7 9.5 6.3 1.1 8.9 4.4 1.4 1 0 0 1 1 1 0 Herpesvirus UL56 protein LIM PF00412.17 ERZ97014.1 - 1.3e-09 37.9 1.5 1.6e-09 37.6 1.0 1.1 1 0 0 1 1 1 1 LIM domain Ecl1 PF12855.2 ERZ97014.1 - 0.067 12.4 2.2 0.098 11.9 1.5 1.3 1 0 0 1 1 1 0 Life-span regulatory factor zf-dskA_traR PF01258.12 ERZ97014.1 - 0.6 9.8 3.8 2 8.2 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zinc_ribbon_6 PF14599.1 ERZ97014.1 - 0.61 9.9 5.7 2 8.2 1.1 2.1 1 1 1 2 2 2 0 Zinc-ribbon RNase_T PF00929.19 ERZ97015.1 - 2.9e-25 89.4 0.0 5.7e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.15 ERZ97015.1 - 0.0017 17.8 0.1 0.011 15.1 0.0 2.1 1 1 0 1 1 1 1 3'-5' exonuclease DUF2410 PF10307.4 ERZ97016.1 - 1.3e-40 138.8 3.3 8.3e-26 90.5 0.2 2.2 1 1 1 2 2 2 2 Hypothetical protein (DUF2410) ATP-synt_J PF04911.7 ERZ97017.1 - 7.5e-12 44.5 0.1 8.1e-12 44.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain zf-RING_2 PF13639.1 ERZ97018.1 - 3.9e-08 32.9 6.4 9.2e-08 31.8 4.4 1.7 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ERZ97018.1 - 6.1e-08 32.6 4.4 1.1e-07 31.8 3.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ERZ97018.1 - 1.5e-05 24.7 2.1 2.4e-05 24.0 1.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ERZ97018.1 - 0.00028 20.5 6.7 0.00058 19.5 4.7 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ERZ97018.1 - 0.0015 18.5 3.5 0.0015 18.5 2.4 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ERZ97018.1 - 0.0016 18.0 6.2 0.0034 17.0 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ97018.1 - 0.011 15.4 5.8 0.021 14.5 4.0 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 ERZ97018.1 - 0.24 11.4 8.0 6.9 6.7 5.6 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 ERZ97018.1 - 0.97 9.5 5.3 2.3 8.3 3.7 1.7 1 1 0 1 1 1 0 RING-variant domain DEAD PF00270.24 ERZ97019.1 - 7.2e-45 152.5 0.5 7.2e-44 149.2 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ97019.1 - 4.4e-26 90.5 0.1 1.1e-25 89.2 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ERZ97019.1 - 1e-08 34.3 0.0 2.6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 ERZ97019.1 - 1.3e-06 28.3 3.1 4.2e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ERZ97019.1 - 0.03 14.4 0.4 0.15 12.1 0.3 2.1 1 1 0 1 1 1 0 AAA domain PTA_PTB PF01515.14 ERZ97019.1 - 0.072 12.1 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase Syntaxin_2 PF14523.1 ERZ97019.1 - 0.09 12.8 0.1 0.09 12.8 0.1 2.4 3 0 0 3 3 3 0 Syntaxin-like protein AAA_19 PF13245.1 ERZ97019.1 - 0.13 12.0 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain CH PF00307.26 ERZ97020.1 - 6.4e-37 125.8 0.6 5.3e-18 65.0 0.0 3.2 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.5 ERZ97020.1 - 2.6e-20 72.1 0.1 1.1e-19 70.1 0.0 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.3 ERZ97020.1 - 1.2e-08 34.4 1.3 5.7e-05 22.6 0.1 3.1 3 0 0 3 3 3 2 CAMSAP CH domain EF-hand_6 PF13405.1 ERZ97020.1 - 0.00021 20.9 0.1 0.0015 18.2 0.0 2.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 ERZ97020.1 - 0.00063 18.8 0.0 0.0021 17.2 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 ERZ97020.1 - 0.0064 16.6 0.2 0.031 14.4 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain pair TroA PF01297.12 ERZ97020.1 - 0.017 14.3 0.1 0.035 13.3 0.1 1.6 1 1 0 1 1 1 0 Periplasmic solute binding protein family Laminin_II PF06009.7 ERZ97020.1 - 0.019 14.7 4.3 0.033 13.9 1.3 2.6 2 0 0 2 2 2 0 Laminin Domain II Spectrin PF00435.16 ERZ97020.1 - 0.025 14.8 5.5 0.35 11.1 0.2 3.4 3 1 0 3 3 3 0 Spectrin repeat SseC PF04888.7 ERZ97020.1 - 0.2 10.9 0.5 0.41 9.9 0.3 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Baculo_PEP_C PF04513.7 ERZ97020.1 - 0.54 10.0 5.4 0.21 11.3 0.9 2.4 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF972 PF06156.8 ERZ97020.1 - 1.4 9.3 5.2 7.1 7.0 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Fib_alpha PF08702.5 ERZ97020.1 - 5.2 7.1 9.2 0.46 10.6 0.5 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Sen15 PF09631.5 ERZ97021.1 - 1.5e-23 82.9 0.1 1.8e-23 82.6 0.1 1.1 1 0 0 1 1 1 1 Sen15 protein DUF3161 PF11362.3 ERZ97022.1 - 0.0023 17.7 2.0 0.0044 16.8 0.1 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF3161) zf-C2H2 PF00096.21 ERZ97022.1 - 0.14 12.5 2.8 0.28 11.6 2.0 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type Paf1 PF03985.8 ERZ97023.1 - 1.6e-33 116.1 12.5 2e-33 115.7 8.6 1.1 1 0 0 1 1 1 1 Paf1 DUF4194 PF13835.1 ERZ97023.1 - 0.014 14.8 0.2 0.029 13.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) Cyclin_N PF00134.18 ERZ97024.1 - 1.1e-16 60.5 0.3 1.5e-14 53.6 0.1 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.14 ERZ97024.1 - 3.1e-09 36.5 0.8 0.0001 22.0 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C PF02984.14 ERZ97024.1 - 8.9e-06 25.6 0.5 0.0053 16.6 0.0 2.7 2 1 0 2 2 2 2 Cyclin, C-terminal domain An_peroxidase PF03098.10 ERZ97025.1 - 1.6e-83 280.9 0.0 2.2e-83 280.4 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase DOMON PF03351.12 ERZ97025.1 - 1.5e-17 63.6 0.1 3e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 DOMON domain NAD_binding_1 PF00175.16 ERZ97026.1 - 1.5e-17 64.0 0.0 1.5e-13 51.2 0.0 2.4 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ERZ97026.1 - 1.4e-10 41.1 0.0 2.7e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ERZ97026.1 - 7.8e-10 38.8 0.0 1.2e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Dimer_Tnp_hAT PF05699.9 ERZ97027.1 - 8.4e-21 73.3 0.2 9.4e-21 73.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Neogenin_C PF06583.7 ERZ97028.1 - 0.025 14.1 0.7 0.17 11.4 0.0 2.1 2 0 0 2 2 2 0 Neogenin C-terminus Reo_sigmaC PF04582.7 ERZ97028.1 - 0.048 12.8 0.1 0.066 12.3 0.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ADIP PF11559.3 ERZ97028.1 - 0.12 12.2 5.8 0.22 11.4 4.0 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 ERZ97028.1 - 0.21 11.9 2.2 0.43 10.9 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Vac_Fusion PF02346.11 ERZ97028.1 - 0.27 10.6 2.7 3.2 7.2 0.4 2.4 2 0 0 2 2 2 0 Chordopoxvirus fusion protein IncA PF04156.9 ERZ97028.1 - 0.3 10.6 2.5 0.15 11.6 0.2 1.5 2 0 0 2 2 2 0 IncA protein Fib_alpha PF08702.5 ERZ97028.1 - 0.53 10.4 4.0 0.98 9.5 2.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family SlyX PF04102.7 ERZ97028.1 - 1.9 8.9 4.7 3.9 7.9 0.9 2.5 1 1 1 2 2 2 0 SlyX Exo_endo_phos_2 PF14529.1 ERZ97029.1 - 2.1e-10 40.2 3.7 2.1e-10 40.2 2.6 2.3 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ97029.1 - 1.2e-07 31.9 0.0 1.8e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF3808 PF10300.4 ERZ97030.1 - 1.4e-07 30.4 0.0 2.4e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) VanZ PF04892.7 ERZ97032.1 - 2.6e-12 46.8 3.9 4.6e-12 46.0 2.7 1.5 1 1 0 1 1 1 1 VanZ like family DUF2279 PF10043.4 ERZ97032.1 - 0.068 13.4 0.1 0.13 12.5 0.1 1.4 1 1 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2279) DnaJ PF00226.26 ERZ97033.1 - 5.4e-18 64.4 0.3 6.7e-18 64.1 0.2 1.1 1 0 0 1 1 1 1 DnaJ domain DUF3395 PF11875.3 ERZ97034.1 - 3.8e-42 143.4 0.1 3.8e-42 143.4 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DUF2017 PF09438.5 ERZ97034.1 - 0.079 12.5 0.1 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2017) Mito_carr PF00153.22 ERZ97035.1 - 9.4e-74 243.2 1.4 6.1e-24 83.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein UFD1 PF03152.9 ERZ97036.1 - 3.8e-78 260.6 0.0 5e-78 260.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF3290 PF11694.3 ERZ97036.1 - 0.036 13.8 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) DUF3198 PF11433.3 ERZ97037.1 - 0.027 14.3 0.2 0.049 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) DHDPS PF00701.17 ERZ97037.1 - 0.034 12.7 0.0 0.04 12.5 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Rrp15p PF07890.7 ERZ97037.1 - 0.041 13.9 0.1 0.055 13.5 0.1 1.1 1 0 0 1 1 1 0 Rrp15p USP7_ICP0_bdg PF12436.3 ERZ97039.1 - 5e-76 255.2 0.4 5e-76 255.2 0.3 2.3 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ERZ97039.1 - 3.7e-54 183.3 12.1 2.1e-52 177.6 2.8 3.1 3 0 0 3 3 3 3 Ubiquitin-specific protease C-terminal UN_NPL4 PF11543.3 ERZ97039.1 - 0.07 13.4 0.1 1.7 8.9 0.0 3.1 2 1 1 3 3 3 0 Nuclear pore localisation protein NPL4 OSTMP1 PF09777.4 ERZ97041.1 - 0.03 13.5 0.3 0.048 12.8 0.2 1.2 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor DUF1540 PF07561.6 ERZ97041.1 - 0.088 12.8 1.5 0.17 11.9 1.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1540) SPRY PF00622.23 ERZ97042.1 - 2.8e-20 72.6 1.3 3.7e-20 72.2 0.9 1.1 1 0 0 1 1 1 1 SPRY domain BAR PF03114.13 ERZ97045.1 - 1.4e-43 149.0 4.9 2.2e-43 148.3 3.4 1.3 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 ERZ97045.1 - 7.7e-17 60.4 0.6 1.5e-16 59.4 0.4 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ERZ97045.1 - 2.5e-12 46.0 0.1 6.5e-12 44.7 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 ERZ97045.1 - 1.8e-11 43.4 0.1 3.5e-11 42.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain FAM92 PF06730.6 ERZ97045.1 - 0.0026 17.1 6.0 0.0044 16.3 4.1 1.3 1 0 0 1 1 1 1 FAM92 protein Clusterin PF01093.12 ERZ97045.1 - 0.0061 15.4 0.4 0.0061 15.4 0.3 2.2 1 1 1 2 2 2 1 Clusterin Tim54 PF11711.3 ERZ97045.1 - 0.027 13.0 14.4 0.057 12.0 0.5 2.1 1 1 1 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF2360 PF10152.4 ERZ97045.1 - 0.045 14.0 3.8 0.036 14.3 0.8 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) SBF2 PF12335.3 ERZ97045.1 - 0.31 10.3 11.2 0.19 11.0 0.6 3.0 2 1 1 3 3 3 0 Myotubularin protein Sec20 PF03908.8 ERZ97045.1 - 4.6 6.9 6.2 2.1 8.0 0.4 3.1 2 1 1 3 3 3 0 Sec20 Methyltrans_Mon PF14314.1 ERZ97046.1 - 0.076 10.8 0.1 0.072 10.9 0.0 1.0 1 0 0 1 1 1 0 Virus-capping methyltransferase RRM_1 PF00076.17 ERZ97048.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ97048.1 - 0.023 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Syntaxin-6_N PF09177.6 ERZ97048.1 - 0.14 12.6 0.9 0.31 11.4 0.4 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Lipase_3 PF01764.20 ERZ97049.1 - 3e-07 30.1 0.0 1.2e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) UPF0227 PF05728.7 ERZ97049.1 - 0.053 13.2 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Torsin PF06309.6 ERZ97049.1 - 0.057 13.3 0.0 3.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Torsin DDE_3 PF13358.1 ERZ97053.1 - 7.4e-07 29.0 0.0 9.2e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HeH PF12949.2 ERZ97053.1 - 0.0049 16.3 0.3 0.012 15.0 0.2 1.7 1 1 1 2 2 2 1 HeH/LEM domain Ish1 PF10281.4 ERZ97053.1 - 0.0051 16.8 0.4 0.011 15.8 0.2 1.6 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein DDE_3 PF13358.1 ERZ97054.1 - 3e-19 69.2 0.1 3.8e-19 68.8 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.21 ERZ97054.1 - 0.032 14.3 0.0 0.31 11.1 0.0 2.0 1 1 0 1 1 1 0 Integrase core domain AAA_17 PF13207.1 ERZ97054.1 - 0.056 14.2 0.0 0.072 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Ish1 PF10281.4 ERZ97054.1 - 0.14 12.2 0.0 0.38 10.8 0.0 1.9 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein DDE_3 PF13358.1 ERZ97056.1 - 1.8e-22 79.6 0.3 2.8e-21 75.7 0.1 2.6 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_29 PF13551.1 ERZ97056.1 - 0.002 18.2 0.1 0.0061 16.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HeH PF12949.2 ERZ97056.1 - 0.0023 17.4 0.0 0.0068 15.9 0.0 1.8 1 0 0 1 1 1 1 HeH/LEM domain HTH_28 PF13518.1 ERZ97056.1 - 0.0025 17.7 0.0 0.0055 16.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.1 ERZ97056.1 - 0.011 16.5 0.2 0.19 12.5 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain Sigma54_DBD PF04552.8 ERZ97056.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54, DNA binding domain HTH_23 PF13384.1 ERZ97056.1 - 0.02 14.5 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain Mob_Pre PF01076.14 ERZ97056.1 - 0.042 13.4 0.4 0.2 11.2 0.0 2.2 3 0 0 3 3 3 0 Plasmid recombination enzyme HTH_12 PF08461.5 ERZ97056.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain AAA_17 PF13207.1 ERZ97056.1 - 0.062 14.1 0.0 0.19 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain HTH_Tnp_ISL3 PF13542.1 ERZ97056.1 - 0.15 11.2 0.0 0.36 10.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Pkinase_Tyr PF07714.12 ERZ97057.1 - 8.1e-12 44.7 0.0 8.3e-12 44.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97057.1 - 1.8e-08 33.8 0.0 2.2e-08 33.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PC_rep PF01851.17 ERZ97058.1 - 4.8e-19 67.4 6.2 0.00022 21.2 0.0 6.3 6 0 0 6 6 6 4 Proteasome/cyclosome repeat HEAT_2 PF13646.1 ERZ97058.1 - 0.0012 19.1 0.6 0.074 13.3 0.0 3.4 3 0 0 3 3 3 1 HEAT repeats Zw10 PF06248.8 ERZ97058.1 - 0.069 11.2 0.9 0.13 10.4 0.6 1.4 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 HAND PF09110.6 ERZ97058.1 - 7.7 6.9 10.2 7.6 6.9 5.2 2.1 2 0 0 2 2 2 0 HAND RS4NT PF08071.7 ERZ97059.1 - 5.1e-22 77.4 5.8 7e-22 77.0 4.0 1.2 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 ERZ97059.1 - 4e-05 22.9 0.1 5.4e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 S4 domain RabGAP-TBC PF00566.13 ERZ97060.1 - 1.5e-11 44.2 12.7 5.8e-10 39.0 8.8 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain MgtE_N PF03448.12 ERZ97062.1 - 0.023 14.9 0.2 0.036 14.3 0.1 1.2 1 0 0 1 1 1 0 MgtE intracellular N domain GMP_synt_C PF00958.17 ERZ97063.1 - 5.8e-41 138.1 0.1 1.2e-40 137.1 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 ERZ97063.1 - 1.7e-39 135.2 0.0 3.2e-39 134.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.12 ERZ97063.1 - 4.6e-09 35.5 0.1 1.1e-06 27.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 ERZ97063.1 - 1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.11 ERZ97063.1 - 0.00094 17.8 0.1 0.0031 16.1 0.0 1.8 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.8 ERZ97063.1 - 0.0012 18.2 0.0 0.012 14.8 0.0 2.1 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 ERZ97063.1 - 0.018 14.5 0.0 0.038 13.4 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.16 ERZ97063.1 - 0.05 13.1 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase PAPS_reduct PF01507.14 ERZ97063.1 - 0.057 13.2 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Mitochondr_Som1 PF11093.3 ERZ97064.1 - 1.6e-09 37.4 1.1 1.9e-09 37.2 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 MFS_1 PF07690.11 ERZ97065.1 - 3.1e-48 164.2 45.2 8.4e-40 136.5 20.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ERZ97065.1 - 1.5e-42 145.7 22.1 4.2e-29 101.4 6.6 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter ATG22 PF11700.3 ERZ97065.1 - 1.1e-09 37.2 25.8 2.6e-05 22.9 11.4 2.1 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like MFS_1_like PF12832.2 ERZ97065.1 - 7.9e-07 28.7 3.9 0.00067 19.3 0.3 2.9 2 0 0 2 2 2 2 MFS_1 like family OATP PF03137.15 ERZ97065.1 - 0.00045 18.4 1.2 0.00045 18.4 0.8 2.4 4 0 0 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.8 ERZ97065.1 - 0.49 8.4 5.9 2.9 5.8 4.1 2.1 1 1 0 1 1 1 0 Transmembrane secretion effector MFS_1 PF07690.11 ERZ97066.1 - 7e-43 146.6 31.4 1.4e-41 142.3 22.8 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ERZ97066.1 - 5.8e-41 140.5 25.4 9.1e-29 100.3 7.3 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 ERZ97066.1 - 1.9e-10 39.7 17.9 9.4e-06 24.2 5.7 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein ATG22 PF11700.3 ERZ97066.1 - 4.9e-08 31.8 21.2 0.00046 18.7 8.7 2.3 2 1 1 3 3 3 2 Vacuole effluxer Atg22 like OATP PF03137.15 ERZ97066.1 - 0.00011 20.3 0.3 0.013 13.5 0.1 2.9 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.2 ERZ97066.1 - 0.00018 21.2 6.0 0.048 13.4 0.6 2.9 2 0 0 2 2 2 2 MFS_1 like family BT1 PF03092.11 ERZ97066.1 - 0.0068 15.1 5.1 0.03 13.0 0.8 2.8 2 1 1 3 3 3 1 BT1 family Nodulin-like PF06813.8 ERZ97066.1 - 0.0091 15.2 0.3 0.0091 15.2 0.2 3.2 4 0 0 4 4 4 1 Nodulin-like PIG-P PF08510.7 ERZ97066.1 - 0.029 13.9 2.9 3 7.4 0.0 2.8 2 0 0 2 2 2 0 PIG-P DUF4131 PF13567.1 ERZ97066.1 - 0.07 12.5 12.2 1.8 7.9 3.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF912 PF06024.7 ERZ97066.1 - 4.8 7.2 5.5 94 3.1 0.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3169 PF11368.3 ERZ97066.1 - 7.7 5.6 9.6 0.1 11.7 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) MFS_3 PF05977.8 ERZ97066.1 - 8.5 4.3 11.5 43 2.0 7.5 2.3 1 1 0 1 1 1 0 Transmembrane secretion effector Dimer_Tnp_hAT PF05699.9 ERZ97069.1 - 1.6e-13 50.0 0.1 2.3e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RRM_1 PF00076.17 ERZ97070.1 - 0.00018 21.0 0.0 0.00035 20.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.4 ERZ97070.1 - 2.1 6.5 13.9 2.5 6.2 9.6 1.1 1 0 0 1 1 1 0 Transmembrane protein Menin PF05053.8 ERZ97070.1 - 2.7 6.0 6.4 3.5 5.6 4.4 1.3 1 0 0 1 1 1 0 Menin Cys_Met_Meta_PP PF01053.15 ERZ97071.1 - 5.2e-11 41.4 0.1 6.5e-11 41.1 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme eRF1_2 PF03464.10 ERZ97071.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 eRF1 domain 2 Cys_Met_Meta_PP PF01053.15 ERZ97072.1 - 0.00042 18.7 0.0 0.0013 17.1 0.0 1.6 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Gln-synt_C PF00120.19 ERZ97075.1 - 0.021 13.9 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain Dimer_Tnp_hAT PF05699.9 ERZ97079.1 - 1.2e-06 28.0 0.1 2.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region GCIP PF13324.1 ERZ97080.1 - 0.03 13.5 0.6 0.039 13.1 0.4 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Pet127 PF08634.5 ERZ97080.1 - 0.065 12.3 0.1 0.065 12.3 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet127 hDGE_amylase PF14701.1 ERZ97082.1 - 0.03 13.2 0.1 0.038 12.8 0.0 1.3 1 0 0 1 1 1 0 glucanotransferase domain of human glycogen debranching enzyme ATP_bind_3 PF01171.15 ERZ97083.1 - 5.9e-50 169.2 0.0 9.3e-50 168.6 0.0 1.3 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.16 ERZ97083.1 - 3.3e-05 23.5 0.0 5.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase CH PF00307.26 ERZ97083.1 - 0.002 18.1 0.3 0.041 13.9 0.2 2.3 1 1 0 1 1 1 1 Calponin homology (CH) domain QueC PF06508.8 ERZ97083.1 - 0.007 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 ERZ97083.1 - 0.016 13.7 0.0 0.029 12.9 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.12 ERZ97083.1 - 0.064 12.1 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 NAD synthase UDPGP PF01704.13 ERZ97084.1 - 0.095 11.1 0.0 0.11 10.9 0.0 1.0 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase RdRP PF05183.7 ERZ97085.1 - 2.3e-13 49.7 0.1 2.3e-13 49.7 0.0 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase Bunya_NS-S_2 PF03231.8 ERZ97085.1 - 0.18 10.3 0.7 0.56 8.7 0.1 1.8 1 1 1 2 2 2 0 Bunyavirus non-structural protein NS-S UQ_con PF00179.21 ERZ97087.1 - 5.4e-37 126.3 0.0 1.2e-36 125.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Membralin PF09746.4 ERZ97087.1 - 0.32 10.0 1.3 0.49 9.3 0.5 1.6 1 1 0 1 1 1 0 Tumour-associated protein DUF605 PF04652.11 ERZ97087.1 - 0.75 9.1 20.0 1 8.7 13.9 1.1 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 ERZ97087.1 - 0.97 9.2 16.5 1.2 8.9 11.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HEAT PF02985.17 ERZ97088.1 - 2.6e-43 142.2 19.1 9.1e-05 22.2 0.0 13.3 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.1 ERZ97088.1 - 1.2e-32 112.0 7.9 1.6e-08 34.7 0.0 6.2 3 1 3 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.2 ERZ97088.1 - 1.9e-12 47.4 7.3 0.00079 19.7 0.1 6.9 3 2 7 10 10 10 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 ERZ97088.1 - 3.8e-10 38.7 7.0 7.2e-06 24.6 0.3 3.5 3 1 0 3 3 3 3 Adaptin N terminal region HEAT_EZ PF13513.1 ERZ97088.1 - 6.3e-10 39.2 14.6 0.0031 17.9 0.1 8.6 6 2 3 9 9 9 2 HEAT-like repeat Cnd1 PF12717.2 ERZ97088.1 - 0.00061 19.6 1.0 4.3 7.1 0.0 3.8 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 ERZ97088.1 - 0.00086 18.7 1.5 3.3 7.0 0.1 4.4 2 2 2 4 4 4 2 CLASP N terminal DUF2435 PF10363.4 ERZ97088.1 - 0.011 15.5 2.3 4.6 7.2 0.0 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF2435) Arm PF00514.18 ERZ97088.1 - 0.28 11.0 4.7 25 4.9 0.0 5.0 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat RVT_1 PF00078.22 ERZ97089.1 - 0.002 17.5 0.0 0.0059 15.9 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_5 PF07728.9 ERZ97091.1 - 2.2e-05 24.2 0.0 0.00086 19.0 0.0 3.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ERZ97091.1 - 0.00015 22.0 0.3 0.023 14.9 0.0 4.1 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ERZ97091.1 - 0.00023 21.2 0.0 0.04 13.9 0.0 3.2 2 0 0 2 2 2 1 Sigma-54 interaction domain Miro PF08477.8 ERZ97091.1 - 0.00046 20.6 0.4 0.0053 17.2 0.0 3.0 2 1 0 2 2 2 1 Miro-like protein ABC_tran PF00005.22 ERZ97091.1 - 0.0012 19.1 0.0 0.13 12.6 0.0 3.3 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.1 ERZ97091.1 - 0.0014 18.8 4.8 0.13 12.3 0.1 5.1 4 1 0 4 4 4 1 AAA domain AAA_16 PF13191.1 ERZ97091.1 - 0.53 10.2 0.1 8.2 6.3 0.0 2.9 2 1 1 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 ERZ97091.1 - 0.96 10.2 4.9 1.7 9.5 0.0 4.2 4 0 0 4 4 4 0 AAA domain PHF5 PF03660.9 ERZ97092.1 - 1.7e-49 166.3 11.4 1.9e-49 166.1 7.9 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.2 ERZ97092.1 - 0.14 11.9 13.1 0.15 11.8 0.8 2.8 1 1 1 2 2 2 0 Double zinc ribbon PolC_DP2 PF03833.8 ERZ97092.1 - 0.33 8.5 6.2 0.34 8.5 4.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PHD PF00628.24 ERZ97092.1 - 2 8.1 15.5 0.062 13.0 4.8 2.5 1 1 1 2 2 2 0 PHD-finger Choline_transpo PF04515.7 ERZ97093.1 - 6.7e-49 166.4 30.7 6.7e-49 166.4 21.3 2.3 2 1 0 2 2 2 2 Plasma-membrane choline transporter DUF569 PF04601.8 ERZ97095.1 - 0.034 13.5 0.7 0.069 12.5 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF569) MMR1 PF08505.5 ERZ97095.1 - 0.46 10.4 20.0 4.1 7.3 13.9 1.9 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Hid1 PF12722.2 ERZ97095.1 - 0.67 7.5 10.2 0.73 7.4 7.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1675 PF07897.6 ERZ97095.1 - 3.1 7.5 14.7 3.9 7.2 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FAM60A PF15396.1 ERZ97095.1 - 4.2 7.0 14.4 6.8 6.3 9.9 1.4 1 1 0 1 1 1 0 Protein Family FAM60A DNA_pol_viral_N PF00242.12 ERZ97095.1 - 7.6 5.4 13.3 10 5.0 9.2 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Macoilin PF09726.4 ERZ97095.1 - 8 4.6 14.4 9.3 4.3 10.0 1.1 1 0 0 1 1 1 0 Transmembrane protein ATP-synt_E PF05680.7 ERZ97098.1 - 3.9e-18 65.2 0.1 3.9e-18 65.1 0.1 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF4422 PF14393.1 ERZ97098.1 - 0.015 14.9 0.1 0.015 14.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) Thioredoxin_7 PF13899.1 ERZ97099.1 - 1.3e-12 47.5 0.0 2.9e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.1 ERZ97099.1 - 5.6e-09 35.3 1.4 8.1e-09 34.8 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.15 ERZ97099.1 - 8.8e-09 35.3 0.0 1.9e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.10 ERZ97099.1 - 0.047 13.4 0.1 0.079 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.1 ERZ97099.1 - 0.071 13.3 0.1 0.33 11.1 0.0 2.1 2 1 0 2 2 2 0 Thioredoxin-like domain SIS PF01380.17 ERZ97100.1 - 4.1e-62 207.5 0.1 1.1e-33 115.5 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 ERZ97100.1 - 1.9e-28 99.2 0.0 1.5e-21 76.5 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 ERZ97100.1 - 6.9e-20 71.3 0.0 1.4e-19 70.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 ERZ97100.1 - 7.6e-15 54.7 0.0 1.6e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 ERZ97100.1 - 7e-07 28.1 0.0 1.4e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 ERZ97100.1 - 0.0038 16.9 0.0 0.044 13.4 0.0 2.6 2 1 0 2 2 2 1 SIS domain Sel1 PF08238.7 ERZ97101.1 - 3.9e-81 265.7 28.6 7.6e-13 48.6 0.1 8.0 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ERZ97101.1 - 1.2e-07 31.6 8.8 3.8 8.1 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97101.1 - 0.00092 19.8 0.5 8.3 7.2 0.0 4.1 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97101.1 - 0.004 16.7 5.1 0.004 16.7 3.5 5.7 3 2 1 5 5 5 2 TPR repeat TPR_17 PF13431.1 ERZ97101.1 - 0.046 13.9 16.0 23 5.4 0.0 7.4 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97101.1 - 1.1 9.2 20.7 0.58 10.1 0.5 6.0 4 3 2 6 6 6 0 Tetratricopeptide repeat DUF2812 PF11193.3 ERZ97101.1 - 7.9 6.6 9.5 0.95 9.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2812) MIT PF04212.13 ERZ97101.1 - 8.2 6.3 17.9 1.3 8.9 1.4 5.8 6 2 2 8 8 8 0 MIT (microtubule interacting and transport) domain Transket_pyr PF02779.19 ERZ97102.1 - 9e-45 152.3 0.0 1.6e-44 151.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ERZ97102.1 - 1.9e-37 127.9 0.0 1.6e-36 124.9 0.0 2.1 2 0 0 2 2 2 1 Transketolase, C-terminal domain Pantoate_transf PF02548.10 ERZ97104.1 - 4.1e-111 370.2 0.1 4.9e-111 370.0 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 ERZ97104.1 - 5.2e-06 25.8 0.0 3.6e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Poxvirus_B22R_C PF13168.1 ERZ97104.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal WD40 PF00400.27 ERZ97105.1 - 4.4e-51 169.0 18.1 8e-13 47.7 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 ERZ97105.1 - 6.5e-07 29.2 10.7 0.087 12.5 0.1 4.6 2 2 3 5 5 5 4 Transcription factor IIIC subunit delta N-term DUF3752 PF12572.3 ERZ97106.1 - 5.4e-29 101.2 15.7 5.4e-29 101.2 10.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Got1 PF04178.7 ERZ97107.1 - 3.7e-35 120.5 11.7 1.2e-34 118.9 8.3 1.5 2 0 0 2 2 2 1 Got1/Sft2-like family PSS PF03034.10 ERZ97107.1 - 0.018 14.4 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 Phosphatidyl serine synthase GP41 PF00517.12 ERZ97107.1 - 0.057 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Retroviral envelope protein EXS PF03124.9 ERZ97107.1 - 0.061 12.3 0.9 0.064 12.2 0.6 1.1 1 0 0 1 1 1 0 EXS family DUF3007 PF11460.3 ERZ97107.1 - 1.5 8.9 4.6 0.61 10.1 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) NfeD PF01957.13 ERZ97107.1 - 4.9 7.2 6.8 0.88 9.6 1.9 1.7 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding SdpI PF13630.1 ERZ97107.1 - 6.9 6.4 10.6 1.5 8.6 0.3 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family Lectin_leg-like PF03388.8 ERZ97108.1 - 3.4e-68 229.1 0.4 4.4e-68 228.8 0.3 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.14 ERZ97108.1 - 0.00046 19.6 0.1 0.0036 16.6 0.1 2.1 1 1 0 1 1 1 1 Legume lectin domain RE_EcoO109I PF14511.1 ERZ97110.1 - 0.11 11.9 1.5 0.36 10.2 0.2 2.3 2 0 0 2 2 2 0 Type II restriction endonuclease EcoO109I NmrA PF05368.8 ERZ97111.1 - 2.3e-38 131.7 0.4 2.7e-38 131.5 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ97111.1 - 1.3e-13 51.3 0.0 2e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ERZ97111.1 - 2e-06 26.7 0.0 3.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ERZ97111.1 - 6.9e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.13 ERZ97111.1 - 7.5e-06 25.9 0.1 1.6e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.5 ERZ97111.1 - 1.4e-05 24.8 0.0 3.2e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.16 ERZ97111.1 - 2.7e-05 23.7 0.1 4.7e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 ERZ97111.1 - 0.0018 17.3 0.1 0.0032 16.4 0.0 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 ERZ97111.1 - 0.034 14.5 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 ERZ97111.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 ERZ97111.1 - 0.07 12.0 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Shikimate_DH PF01488.15 ERZ97111.1 - 0.11 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase T4_neck-protein PF11649.3 ERZ97112.1 - 0.046 12.9 0.7 0.063 12.5 0.5 1.2 1 0 0 1 1 1 0 Virus neck protein FcoT PF10862.3 ERZ97112.1 - 0.051 13.1 0.3 0.055 13.0 0.2 1.2 1 0 0 1 1 1 0 FcoT-like thioesterase domain DUF4065 PF13274.1 ERZ97112.1 - 0.059 14.0 0.4 0.083 13.6 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) DUF1140 PF06600.6 ERZ97112.1 - 0.075 13.1 0.6 0.13 12.4 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1140) DZR PF12773.2 ERZ97113.1 - 0.41 10.5 10.8 0.17 11.6 1.6 2.9 3 0 0 3 3 3 0 Double zinc ribbon Spt4 PF06093.8 ERZ97113.1 - 3.8 7.4 11.7 0.89 9.4 1.6 3.0 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger DivIC PF04977.10 ERZ97115.1 - 0.0031 16.9 3.4 0.0031 16.9 2.4 2.3 3 0 0 3 3 3 1 Septum formation initiator T4SS PF07996.6 ERZ97115.1 - 0.0091 15.8 5.1 0.0091 15.8 3.5 1.7 1 1 0 1 1 1 1 Type IV secretion system proteins Katanin_con80 PF13925.1 ERZ97115.1 - 0.015 15.0 2.2 0.036 13.8 1.5 1.6 1 0 0 1 1 1 0 con80 domain of Katanin FlaC_arch PF05377.6 ERZ97115.1 - 0.031 14.1 5.9 0.068 13.0 2.0 2.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.6 ERZ97115.1 - 0.1 13.0 5.4 0.48 10.8 2.2 2.7 2 1 0 2 2 2 0 Syntaxin 6, N-terminal IncA PF04156.9 ERZ97115.1 - 0.11 12.0 3.3 0.16 11.5 2.3 1.2 1 0 0 1 1 1 0 IncA protein DUF3373 PF11853.3 ERZ97115.1 - 0.15 10.5 4.3 0.26 9.7 2.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) DUF4349 PF14257.1 ERZ97115.1 - 0.2 10.8 0.7 0.34 10.0 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF972 PF06156.8 ERZ97115.1 - 0.33 11.3 9.4 4.5 7.6 3.8 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF972) Tropomyosin_1 PF12718.2 ERZ97115.1 - 0.41 10.5 9.4 0.079 12.8 3.7 1.8 2 0 0 2 2 2 0 Tropomyosin like Syntaxin PF00804.20 ERZ97115.1 - 0.46 10.6 11.6 0.2 11.8 3.9 2.7 1 1 1 2 2 2 0 Syntaxin DUF2346 PF09803.4 ERZ97115.1 - 0.75 9.6 3.9 1.9 8.3 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) Adaptin_binding PF10199.4 ERZ97115.1 - 1.5 9.1 10.9 20 5.4 5.1 2.3 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF869 PF05911.6 ERZ97115.1 - 6 4.9 14.2 1.2 7.2 6.8 1.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) PRP1_N PF06424.7 ERZ97116.1 - 0.041 14.2 2.3 0.041 14.2 1.6 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal RRN3 PF05327.6 ERZ97117.1 - 0.024 12.7 3.3 0.026 12.6 2.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RasGAP PF00616.14 ERZ97118.1 - 0.0037 16.9 0.2 0.0071 16.0 0.1 1.4 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Arteri_GP4 PF02497.10 ERZ97118.1 - 0.0058 16.5 1.0 0.0098 15.8 0.7 1.3 1 0 0 1 1 1 1 Arterivirus glycoprotein FYVE PF01363.16 ERZ97118.1 - 0.0098 15.7 13.0 11 5.9 9.0 3.0 1 1 0 1 1 1 1 FYVE zinc finger DUF4557 PF15101.1 ERZ97118.1 - 0.14 11.9 0.1 0.21 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF3039 PF11238.3 ERZ97118.1 - 0.35 10.3 0.0 0.35 10.3 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) Pkinase PF00069.20 ERZ97119.1 - 0.00021 20.5 0.3 0.00073 18.7 0.0 1.7 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97119.1 - 0.00026 20.1 0.1 0.00044 19.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2553 PF10830.3 ERZ97119.1 - 0.029 14.8 0.3 0.05 14.1 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2553) HECT PF00632.20 ERZ97119.1 - 0.039 13.0 0.4 0.043 12.9 0.3 1.0 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) SMI1_KNR4 PF09346.5 ERZ97120.1 - 0.055 13.4 0.1 0.14 12.1 0.0 1.6 1 1 1 2 2 2 0 SMI1 / KNR4 family (SUKH-1) PH_BEACH PF14844.1 ERZ97121.1 - 6e-15 54.9 0.2 6e-15 54.9 0.1 2.6 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.1 ERZ97121.1 - 2e-10 41.1 0.0 6.9e-10 39.3 0.0 1.8 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Beach PF02138.13 ERZ97121.1 - 3.5e-09 36.4 0.2 1.6e-08 34.3 0.1 2.2 1 0 0 1 1 1 1 Beige/BEACH domain SHOCT PF09851.4 ERZ97123.1 - 0.076 12.5 0.1 0.16 11.5 0.1 1.6 1 0 0 1 1 1 0 Short C-terminal domain DNA_pol3_delta2 PF13177.1 ERZ97123.1 - 0.1 12.2 1.4 0.2 11.3 1.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Pkinase_Tyr PF07714.12 ERZ97124.1 - 2.5e-24 85.7 0.2 4.4e-24 84.9 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97124.1 - 3e-23 82.3 3.9 8e-23 80.9 2.7 1.7 1 1 0 1 1 1 1 Protein kinase domain Tat PF00539.13 ERZ97124.1 - 1.2 8.8 8.6 2.6 7.7 0.5 2.5 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) BTB PF00651.26 ERZ97126.1 - 2.3e-12 46.9 0.0 4.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain RasGAP PF00616.14 ERZ97127.1 - 0.0067 16.1 0.1 0.074 12.7 0.0 2.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Tetrabrachion PF11401.3 ERZ97127.1 - 0.25 11.1 2.5 0.64 9.8 1.7 1.6 1 0 0 1 1 1 0 Tetrabrachion BTB PF00651.26 ERZ97129.1 - 1.7e-18 66.6 0.1 4.1e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97129.1 - 2.4e-08 34.0 1.9 7.7e-08 32.4 1.3 1.9 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ97129.1 - 0.0011 18.8 6.3 0.0039 17.0 0.5 4.0 4 1 1 5 5 5 1 BTB And C-terminal Kelch SURF6 PF04935.7 ERZ97130.1 - 0.095 11.9 2.3 0.13 11.4 1.6 1.3 1 0 0 1 1 1 0 Surfeit locus protein 6 CDC45 PF02724.9 ERZ97130.1 - 0.34 8.9 5.3 0.37 8.7 3.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF506 PF04720.7 ERZ97130.1 - 0.52 9.9 3.8 0.65 9.5 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) Upf2 PF04050.9 ERZ97130.1 - 1.1 8.9 9.9 1.6 8.4 6.9 1.3 1 1 0 1 1 1 0 Up-frameshift suppressor 2 YL1 PF05764.8 ERZ97130.1 - 1.4 8.4 10.5 1.8 8.0 7.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein PBP1_TM PF14812.1 ERZ97130.1 - 2.8 8.3 17.0 9.2 6.6 11.8 1.8 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SF3a60_bindingd PF12108.3 ERZ97131.1 - 0.016 14.7 3.7 0.032 13.7 2.6 1.5 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain IPPT PF01715.12 ERZ97132.1 - 1.2e-65 221.0 0.3 1.7e-65 220.5 0.2 1.2 1 0 0 1 1 1 1 IPP transferase AAA_18 PF13238.1 ERZ97132.1 - 7.2e-05 23.0 1.6 0.0018 18.5 1.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ERZ97132.1 - 0.00087 20.1 1.4 0.004 17.9 0.1 2.8 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ERZ97132.1 - 0.0039 17.0 0.1 0.82 9.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain SKI PF01202.17 ERZ97132.1 - 0.033 14.0 0.1 0.88 9.4 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase AAA_22 PF13401.1 ERZ97132.1 - 0.06 13.4 0.1 4.7 7.3 0.1 2.6 1 1 1 2 2 2 0 AAA domain zf-U1 PF06220.7 ERZ97132.1 - 0.066 12.7 2.9 0.18 11.3 0.6 2.6 2 1 0 2 2 2 0 U1 zinc finger IPT PF01745.11 ERZ97132.1 - 0.082 12.0 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Isopentenyl transferase zf-C2H2_jaz PF12171.3 ERZ97132.1 - 0.11 12.6 0.9 0.43 10.7 0.7 2.1 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding UQ_con PF00179.21 ERZ97133.1 - 7.6e-17 61.0 0.0 8.6e-17 60.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ERZ97133.1 - 0.0022 17.6 0.0 0.0029 17.2 0.0 1.2 1 0 0 1 1 1 1 UEV domain tRNA-synt_2 PF00152.15 ERZ97134.1 - 5.8e-79 265.3 0.8 5.8e-79 265.3 0.5 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ERZ97134.1 - 4.3e-06 26.4 0.5 8e-06 25.6 0.3 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ERZ97134.1 - 0.0028 16.9 0.7 0.12 11.5 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) Amidinotransf PF02274.12 ERZ97134.1 - 0.054 12.5 0.0 0.091 11.8 0.0 1.4 1 0 0 1 1 1 0 Amidinotransferase NARP1 PF12569.3 ERZ97134.1 - 1.6 7.3 10.2 4.2 6.0 6.3 1.9 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Coatomer_E PF04733.9 ERZ97135.1 - 1.5e-90 303.3 8.2 1.4e-89 300.1 5.7 1.9 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.1 ERZ97135.1 - 4.2e-09 36.5 4.4 0.0084 16.4 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97135.1 - 9.3e-08 32.1 5.2 0.0034 17.5 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ERZ97135.1 - 5.4e-06 25.9 1.3 0.023 14.3 0.0 4.0 3 2 1 4 4 4 3 TPR repeat TPR_16 PF13432.1 ERZ97135.1 - 1.2e-05 25.7 0.0 0.36 11.5 0.0 3.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97135.1 - 2.3e-05 24.2 0.8 0.015 15.1 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97135.1 - 0.00065 20.1 0.2 0.14 12.8 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ97135.1 - 0.0011 18.7 10.3 0.14 12.1 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ97135.1 - 0.0061 16.1 5.1 2.7 7.7 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF3114 PF11311.3 ERZ97135.1 - 0.04 13.2 0.0 0.08 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) Type_III_YscG PF09477.5 ERZ97135.1 - 0.053 13.6 0.5 11 6.0 0.0 3.2 2 1 3 5 5 5 0 Bacterial type II secretion system chaperone protein (type_III_yscG) Tox-MPTase2 PF15638.1 ERZ97135.1 - 0.1 12.1 0.8 0.26 10.7 0.3 1.9 1 1 1 2 2 2 0 Metallopeptidase toxin 2 TPR_8 PF13181.1 ERZ97135.1 - 0.2 11.5 6.5 38 4.3 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat KAT11 PF08214.6 ERZ97136.1 - 2.1e-41 142.1 10.6 3e-41 141.6 7.4 1.2 1 0 0 1 1 1 1 Histone acetylation protein F-box-like PF12937.2 ERZ97137.1 - 0.0093 15.6 0.1 0.024 14.3 0.1 1.7 1 0 0 1 1 1 1 F-box-like Nop25 PF09805.4 ERZ97141.1 - 0.015 15.3 3.2 0.018 15.1 2.2 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TBPIP PF07106.8 ERZ97141.1 - 0.066 12.7 6.2 0.12 11.8 4.3 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF685 PF05085.7 ERZ97141.1 - 0.086 11.8 2.7 0.094 11.7 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF685) FAM176 PF14851.1 ERZ97141.1 - 0.17 11.5 2.3 0.19 11.4 1.2 1.4 1 1 0 1 1 1 0 FAM176 family GrpE PF01025.14 ERZ97141.1 - 0.32 10.5 6.3 0.43 10.1 4.3 1.3 1 0 0 1 1 1 0 GrpE Mnd1 PF03962.10 ERZ97141.1 - 0.46 10.1 6.8 0.57 9.8 4.7 1.2 1 0 0 1 1 1 0 Mnd1 family Striatin PF08232.7 ERZ97141.1 - 0.47 10.7 7.0 0.7 10.2 4.9 1.2 1 0 0 1 1 1 0 Striatin family DUF904 PF06005.7 ERZ97141.1 - 0.52 10.6 8.3 0.77 10.1 5.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF904) THRAP3_BCLAF1 PF15440.1 ERZ97141.1 - 1.4 7.4 9.0 1.8 7.1 6.2 1.0 1 0 0 1 1 1 0 THRAP3/BCLAF1 family DUF4446 PF14584.1 ERZ97141.1 - 1.4 8.6 4.7 1.4 8.7 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) Hemocyanin_C PF03723.9 ERZ97142.1 - 6.8e-23 81.0 0.0 7.8e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 Hemocyanin, ig-like domain SSP160 PF06933.6 ERZ97143.1 - 0.34 8.8 6.7 0.38 8.6 4.6 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 p450 PF00067.17 ERZ97145.1 - 1.3e-34 119.4 0.0 1.5e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ERZ97145.1 - 0.038 13.9 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) Sel1 PF08238.7 ERZ97146.1 - 2.2e-12 47.1 0.6 9.2e-09 35.6 0.0 2.1 2 0 0 2 2 2 2 Sel1 repeat MACPF PF01823.14 ERZ97147.1 - 0.0018 18.0 1.2 0.018 14.7 0.1 2.4 2 0 0 2 2 2 1 MAC/Perforin domain TPR_11 PF13414.1 ERZ97148.1 - 1.7e-16 59.5 17.6 1.1e-07 31.3 0.3 4.2 2 1 2 5 5 5 4 TPR repeat TPR_2 PF07719.12 ERZ97148.1 - 6.4e-16 56.9 14.9 0.0012 18.5 0.0 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ97148.1 - 1.6e-14 52.7 21.6 1e-05 24.9 0.1 5.5 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97148.1 - 2.7e-10 40.0 6.2 3.3e-05 23.7 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97148.1 - 9.9e-08 31.6 14.9 0.099 12.8 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97148.1 - 1.1e-06 28.6 15.0 3.4e-06 27.0 1.3 3.7 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ERZ97148.1 - 3.7e-06 26.3 32.3 0.0016 18.0 0.3 6.6 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ97148.1 - 6e-06 26.4 0.1 0.21 11.9 0.0 3.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97148.1 - 2.4e-05 24.8 0.0 0.037 14.7 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ97148.1 - 0.0079 16.0 0.0 5.7 6.8 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ97148.1 - 0.0089 16.4 1.7 22 5.7 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97148.1 - 0.0098 16.4 0.0 48 4.9 0.0 4.7 3 1 3 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ97148.1 - 0.099 12.4 3.2 1.4 8.9 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Prokineticin PF06607.6 ERZ97149.1 - 0.0053 16.8 0.1 0.0056 16.7 0.0 1.2 1 1 0 1 1 1 1 Prokineticin Skp1_POZ PF03931.10 ERZ97150.1 - 0.076 13.1 0.2 0.83 9.7 0.0 2.0 1 1 1 2 2 2 0 Skp1 family, tetramerisation domain Sel1 PF08238.7 ERZ97151.1 - 1.5e-73 241.5 14.0 2.9e-10 40.4 0.1 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_17 PF13431.1 ERZ97151.1 - 2.8e-07 30.2 12.5 0.74 10.1 0.8 7.7 7 2 1 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ97151.1 - 1.5e-05 25.1 9.6 2.8 8.5 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat Phage_terminase PF10668.4 ERZ97151.1 - 0.0034 17.1 5.7 22 4.9 0.0 5.4 6 0 0 6 6 6 0 Phage terminase small subunit TPR_16 PF13432.1 ERZ97151.1 - 0.068 13.8 0.0 14 6.4 0.0 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat Chordopox_A13L PF05961.6 ERZ97151.1 - 0.096 12.6 0.8 20 5.2 0.0 3.6 4 0 0 4 4 4 0 Chordopoxvirus A13L protein Fimbrillin_C PF15495.1 ERZ97151.1 - 2.4 8.3 10.0 4.2 7.6 0.0 4.5 3 1 1 4 4 4 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal BTB PF00651.26 ERZ97153.1 - 1.5e-10 40.9 0.1 4.5e-10 39.4 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97153.1 - 6.2e-09 35.9 1.3 3.2e-08 33.6 0.2 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ97153.1 - 0.00013 21.7 4.3 0.0016 18.2 1.3 2.8 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF2649 PF10854.3 ERZ97153.1 - 0.23 11.6 2.7 4.6 7.4 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) Pkinase_Tyr PF07714.12 ERZ97155.1 - 2.7e-09 36.5 0.0 4.2e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97155.1 - 1.9e-07 30.4 0.1 3.9e-07 29.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Stc1 PF12898.2 ERZ97155.1 - 0.013 15.5 0.8 0.024 14.6 0.6 1.5 1 0 0 1 1 1 0 Stc1 domain zinc-ribbons_6 PF07191.7 ERZ97155.1 - 0.017 14.9 2.2 0.028 14.1 1.1 1.6 2 0 0 2 2 2 0 zinc-ribbons F-box-like PF12937.2 ERZ97159.1 - 0.0007 19.2 1.1 0.0018 17.9 0.7 1.7 1 0 0 1 1 1 1 F-box-like TLD PF07534.11 ERZ97160.1 - 2.3e-14 53.5 0.2 4.8e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ97160.1 - 7.1e-08 32.2 1.4 5.5e-06 26.1 0.6 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch SpvD PF05563.7 ERZ97160.1 - 0.045 13.2 2.7 0.052 13.0 0.1 2.2 2 1 1 3 3 3 0 Salmonella plasmid virulence protein SpvD DUF1295 PF06966.7 ERZ97161.1 - 2.5e-52 177.5 2.3 3.4e-52 177.0 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 ERZ97161.1 - 5.2e-05 23.3 0.1 5.2e-05 23.3 0.1 2.8 2 1 1 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.11 ERZ97161.1 - 0.0013 18.4 2.9 0.082 12.6 0.1 2.8 2 1 0 3 3 3 2 3-oxo-5-alpha-steroid 4-dehydrogenase BLOC1_2 PF10046.4 ERZ97163.1 - 0.0063 16.6 0.1 0.026 14.6 0.0 1.8 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlxA PF14282.1 ERZ97163.1 - 0.024 14.5 1.1 0.024 14.5 0.7 2.2 2 1 1 3 3 3 0 FlxA-like protein DUF4048 PF13257.1 ERZ97163.1 - 0.049 13.2 3.1 0.059 13.0 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) FKS1_dom1 PF14288.1 ERZ97163.1 - 0.24 11.3 1.3 0.33 10.8 0.9 1.3 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 FliD_N PF02465.13 ERZ97163.1 - 0.38 11.1 2.4 0.58 10.5 1.6 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Syntaxin PF00804.20 ERZ97163.1 - 1.1 9.4 4.7 2.3 8.4 3.2 1.6 1 1 0 1 1 1 0 Syntaxin F-box-like PF12937.2 ERZ97165.1 - 0.00028 20.5 0.5 0.0011 18.7 0.3 2.0 1 0 0 1 1 1 1 F-box-like CRAL_TRIO_2 PF13716.1 ERZ97166.1 - 0.33 10.8 2.7 0.5 10.2 0.4 2.2 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain Transposase_21 PF02992.9 ERZ97167.1 - 1.3e-11 44.0 0.1 1.4e-11 43.9 0.1 1.0 1 0 0 1 1 1 1 Transposase family tnp2 zf-C3HC PF07967.8 ERZ97168.1 - 0.0047 16.7 1.7 0.0053 16.5 1.2 1.1 1 0 0 1 1 1 1 C3HC zinc finger-like PyrI_C PF02748.10 ERZ97168.1 - 0.0096 15.3 0.1 0.023 14.1 0.1 1.7 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain PurS PF02700.9 ERZ97168.1 - 0.014 15.3 0.3 0.026 14.4 0.2 1.4 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase FANCI_S3 PF14677.1 ERZ97168.1 - 0.074 12.4 0.5 0.092 12.1 0.3 1.1 1 0 0 1 1 1 0 FANCI solenoid 3 zf-BED PF02892.10 ERZ97168.1 - 0.097 12.4 2.2 0.14 11.9 0.1 2.1 2 0 0 2 2 2 0 BED zinc finger DUF4163 PF13739.1 ERZ97168.1 - 0.19 12.5 2.6 0.26 12.0 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4163) PSP PF04046.11 ERZ97169.1 - 1.8e-11 43.1 0.3 3.2e-11 42.4 0.2 1.3 1 0 0 1 1 1 1 PSP CoA_binding PF02629.14 ERZ97170.1 - 1.3e-26 92.9 1.2 7.6e-26 90.4 0.1 2.3 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 ERZ97170.1 - 2.3e-24 85.7 0.1 3.7e-24 85.0 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 ERZ97170.1 - 1.5e-06 27.8 0.0 2.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 ERZ97170.1 - 7.2e-05 22.9 0.3 0.00038 20.5 0.0 2.2 2 1 0 2 2 2 1 CoA binding domain GFO_IDH_MocA PF01408.17 ERZ97170.1 - 0.077 13.5 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold SNAPc_SNAP43 PF09808.4 ERZ97171.1 - 1.4e-27 96.6 2.5 2e-27 96.1 1.7 1.3 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Tho2 PF11262.3 ERZ97172.1 - 6.5e-84 281.4 2.2 6.5e-84 281.4 1.5 2.6 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 ERZ97172.1 - 4.4e-24 84.0 0.1 1.4e-23 82.4 0.0 2.0 1 0 0 1 1 1 1 Transcription- and export-related complex subunit WD40 PF00400.27 ERZ97173.1 - 2.1e-31 106.6 9.6 7.3e-08 32.0 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ERZ97173.1 - 5.5e-07 29.4 2.5 0.0014 18.3 0.1 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A MutS_V PF00488.16 ERZ97174.1 - 1e-82 277.0 0.0 2e-82 276.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ERZ97174.1 - 8.5e-37 126.9 3.0 8.5e-37 126.9 2.1 2.0 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.13 ERZ97174.1 - 4.6e-12 45.9 1.2 4.6e-12 45.9 0.8 2.6 3 0 0 3 3 3 1 MutS family domain IV AAA_14 PF13173.1 ERZ97174.1 - 0.008 16.0 0.4 0.037 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ERZ97174.1 - 0.01 15.3 0.2 0.032 13.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.1 ERZ97174.1 - 0.52 10.5 19.9 0.015 15.6 3.2 3.5 2 2 0 2 2 2 0 AAA domain PRESAN PF09687.5 ERZ97174.1 - 0.77 9.8 9.4 0.073 13.1 0.6 3.4 2 2 1 3 3 3 0 Plasmodium RESA N-terminal IFRD PF05004.8 ERZ97175.1 - 4e-50 170.6 2.5 5.6e-50 170.1 1.7 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) SNF2_N PF00176.18 ERZ97175.1 - 0.0018 17.1 0.2 0.003 16.3 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain efThoc1 PF11957.3 ERZ97176.1 - 1.7e-67 228.0 21.8 2.6e-67 227.4 15.1 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor PH_11 PF15413.1 ERZ97176.1 - 0.00015 22.0 3.5 0.0043 17.2 0.1 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain Ku_N PF03731.10 ERZ97177.1 - 1e-45 155.9 1.4 1.4e-45 155.4 0.4 1.7 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.11 ERZ97177.1 - 2.5e-40 138.0 0.0 4.5e-40 137.1 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 ERZ97177.1 - 1.5e-11 44.6 0.2 5.2e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA_2 PF13519.1 ERZ97177.1 - 0.0011 19.0 0.1 0.0029 17.7 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ERZ97177.1 - 0.0012 18.5 0.6 0.0024 17.6 0.4 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain HSNSD PF12062.3 ERZ97177.1 - 0.078 11.3 0.0 0.14 10.5 0.0 1.3 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase dsrm PF00035.20 ERZ97178.1 - 5.3e-10 39.7 6.9 0.00028 21.4 0.7 3.4 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ERZ97178.1 - 3.7e-08 33.5 4.4 0.00059 20.0 0.2 4.4 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 AA_permease_2 PF13520.1 ERZ97179.1 - 6.4e-49 166.6 32.2 8.3e-49 166.2 22.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ERZ97179.1 - 1.7e-17 62.9 30.2 2.2e-17 62.5 19.4 2.0 1 1 1 2 2 2 1 Amino acid permease Ald_Xan_dh_C2 PF02738.13 ERZ97180.1 - 1.4e-190 634.2 0.0 1.9e-190 633.8 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.16 ERZ97180.1 - 1.2e-38 132.2 0.0 5.8e-38 130.0 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.17 ERZ97180.1 - 5.7e-32 110.0 0.1 1e-31 109.2 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.15 ERZ97180.1 - 1.2e-28 98.7 0.0 2.5e-28 97.7 0.0 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.12 ERZ97180.1 - 1.3e-27 95.7 0.0 4e-27 94.1 0.0 1.9 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2 PF00111.22 ERZ97180.1 - 4.8e-09 35.8 0.1 1.5e-08 34.2 0.0 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain CBFD_NFYB_HMF PF00808.18 ERZ97181.1 - 8.2e-15 54.6 1.6 8.2e-15 54.6 1.1 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ERZ97181.1 - 4e-06 26.8 0.5 8.8e-06 25.7 0.3 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Aldo_ket_red PF00248.16 ERZ97182.1 - 1.5e-53 181.4 0.1 1.8e-53 181.1 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Fer4_12 PF13353.1 ERZ97182.1 - 0.059 13.4 0.2 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain TGS PF02824.16 ERZ97183.1 - 6.5e-25 86.7 0.0 1.3e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 ERZ97183.1 - 3.4e-17 62.4 0.0 7.9e-17 61.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ERZ97183.1 - 1.6e-10 40.5 0.0 8.7e-10 38.0 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B ArgK PF03308.11 ERZ97183.1 - 0.00011 21.0 1.0 0.0069 15.1 0.2 2.2 2 0 0 2 2 2 2 ArgK protein GTP_EFTU PF00009.22 ERZ97183.1 - 0.00084 18.8 0.2 2.3 7.5 0.0 3.7 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ERZ97183.1 - 0.006 16.4 0.3 1.1 9.0 0.0 2.3 1 1 1 2 2 2 2 Dynamin family DUF211 PF02680.9 ERZ97183.1 - 0.061 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 Miro PF08477.8 ERZ97183.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Rad10 PF03834.9 ERZ97184.1 - 4.6e-31 106.3 0.1 1.3e-30 104.8 0.0 1.8 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) UPF0029 PF01205.14 ERZ97184.1 - 6.6e-30 103.0 0.0 1.3e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 HHH_2 PF12826.2 ERZ97184.1 - 1.4e-06 28.1 0.0 3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.1 ERZ97184.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.18 ERZ97184.1 - 0.0058 16.2 0.0 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Peptidase_M24 PF00557.19 ERZ97185.1 - 1.5e-24 86.7 0.0 2.7e-24 85.9 0.0 1.6 2 0 0 2 2 2 1 Metallopeptidase family M24 Syntaxin-18_N PF10496.4 ERZ97186.1 - 1.4e-16 60.0 1.6 1.4e-16 60.0 1.1 3.7 3 1 1 4 4 4 2 SNARE-complex protein Syntaxin-18 N-terminus FlgI PF02119.11 ERZ97186.1 - 2.2 6.8 9.5 0.59 8.7 2.1 2.3 1 1 1 2 2 2 0 Flagellar P-ring protein Indigoidine_A PF04227.7 ERZ97187.1 - 8e-06 25.2 0.0 1.1e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Indigoidine synthase A like protein Indigoidine_A PF04227.7 ERZ97188.1 - 3.7e-94 315.2 1.1 4.5e-94 314.9 0.7 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein PUA_2 PF14306.1 ERZ97188.1 - 0.027 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 PUA-like domain MMgT PF10270.4 ERZ97189.1 - 0.26 11.7 2.1 0.51 10.7 1.4 1.6 1 1 0 1 1 1 0 Membrane magnesium transporter PepX_N PF09168.5 ERZ97190.1 - 0.013 15.7 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal DUF3399 PF11879.3 ERZ97190.1 - 0.031 14.4 0.0 0.073 13.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3399) POT1 PF02765.12 ERZ97191.1 - 1.7e-14 53.9 0.0 5.1e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 SAD_SRA PF02182.12 ERZ97192.1 - 3.7e-46 156.2 0.0 4.1e-46 156.0 0.0 1.0 1 0 0 1 1 1 1 SAD/SRA domain Peptidase_S10 PF00450.17 ERZ97193.1 - 2.2e-82 277.4 1.1 2.4e-82 277.3 0.8 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_5 PF12695.2 ERZ97193.1 - 0.059 13.1 0.0 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family HMG_box PF00505.14 ERZ97196.1 - 2.3e-07 30.9 1.8 4.4e-07 30.0 1.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ97196.1 - 0.0018 18.5 1.5 0.0031 17.8 1.0 1.4 1 0 0 1 1 1 1 HMG-box domain Histone PF00125.19 ERZ97197.1 - 1.2e-22 79.7 0.1 1.7e-22 79.3 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ERZ97197.1 - 3.6e-06 26.9 0.0 7.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 ERZ97197.1 - 0.00037 20.7 0.0 0.00069 19.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 ERZ97197.1 - 0.0046 15.6 0.5 0.0059 15.3 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein DUF1018 PF06252.7 ERZ97197.1 - 0.082 13.4 0.2 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Apc1 PF12859.2 ERZ97198.1 - 9.3e-10 38.6 0.1 8e-09 35.6 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 ERZ97198.1 - 0.012 15.8 15.5 4.1 7.8 0.0 6.3 6 0 0 6 6 6 0 Proteasome/cyclosome repeat ABC-3 PF00950.12 ERZ97198.1 - 0.27 10.4 0.4 2.4 7.4 0.0 2.4 2 0 0 2 2 2 0 ABC 3 transport family Ribosomal_L7Ae PF01248.21 ERZ97199.1 - 4.1e-26 90.3 0.0 4.8e-26 90.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CENP-F_leu_zip PF10473.4 ERZ97200.1 - 0.00012 22.0 1.2 0.046 13.5 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.6 ERZ97200.1 - 0.00036 19.2 1.9 0.00041 19.1 1.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Prominin PF05478.6 ERZ97200.1 - 0.0008 17.0 1.0 0.0019 15.8 0.7 1.5 1 1 0 1 1 1 1 Prominin DASH_Duo1 PF08651.5 ERZ97200.1 - 0.0022 17.5 1.2 1.5 8.4 0.1 2.3 2 0 0 2 2 2 2 DASH complex subunit Duo1 Mnd1 PF03962.10 ERZ97200.1 - 0.0024 17.5 1.3 0.0031 17.2 0.9 1.1 1 0 0 1 1 1 1 Mnd1 family P4Ha_N PF08336.6 ERZ97200.1 - 0.0028 17.4 0.8 0.036 13.8 0.0 2.1 1 1 1 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Baculo_PEP_C PF04513.7 ERZ97200.1 - 0.0066 16.2 1.0 0.078 12.7 0.7 2.0 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus MCPsignal PF00015.16 ERZ97200.1 - 0.013 15.0 1.9 0.019 14.4 1.3 1.4 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Tropomyosin PF00261.15 ERZ97200.1 - 0.014 14.4 1.6 0.019 14.0 1.1 1.4 1 0 0 1 1 1 0 Tropomyosin DUF4200 PF13863.1 ERZ97200.1 - 0.014 15.2 0.8 0.02 14.8 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Laminin_I PF06008.9 ERZ97200.1 - 0.017 14.4 0.6 0.022 14.0 0.4 1.1 1 0 0 1 1 1 0 Laminin Domain I SNARE PF05739.14 ERZ97200.1 - 0.017 14.7 1.8 0.18 11.4 0.1 2.6 2 1 0 2 2 2 0 SNARE domain DUF745 PF05335.8 ERZ97200.1 - 0.019 14.4 1.7 0.026 14.0 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF3508 PF12018.3 ERZ97200.1 - 0.022 13.7 0.5 0.028 13.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) DUF948 PF06103.6 ERZ97200.1 - 0.03 14.1 1.6 4.3 7.2 0.2 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.7 ERZ97200.1 - 0.039 13.7 2.3 0.17 11.7 1.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CorA PF01544.13 ERZ97200.1 - 0.04 12.9 0.8 0.099 11.6 0.5 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein GrpE PF01025.14 ERZ97200.1 - 0.044 13.3 2.9 0.072 12.6 2.0 1.4 1 1 0 1 1 1 0 GrpE GTPase_Cys_C PF12631.2 ERZ97200.1 - 0.046 14.1 0.1 0.13 12.6 0.0 1.9 1 1 1 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DASH_Spc34 PF08657.5 ERZ97200.1 - 0.054 13.1 1.9 0.16 11.6 0.8 1.8 1 1 1 2 2 2 0 DASH complex subunit Spc34 ApoLp-III PF07464.6 ERZ97200.1 - 0.054 13.5 1.0 0.24 11.4 0.3 2.0 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) IFT57 PF10498.4 ERZ97200.1 - 0.064 11.9 2.2 1.3 7.7 1.7 1.8 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DASH_Dad1 PF08649.5 ERZ97200.1 - 0.069 12.8 1.8 0.68 9.6 0.1 2.6 3 0 0 3 3 2 0 DASH complex subunit Dad1 Sec8_exocyst PF04048.9 ERZ97200.1 - 0.084 12.5 1.9 0.76 9.4 1.4 2.0 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Tweety PF04906.8 ERZ97200.1 - 0.1 10.9 0.4 0.12 10.7 0.3 1.1 1 0 0 1 1 1 0 Tweety NPV_P10 PF05531.7 ERZ97200.1 - 0.12 12.6 2.4 1.4 9.2 1.4 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF869 PF05911.6 ERZ97200.1 - 0.14 10.4 2.8 0.15 10.2 1.9 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) NEP PF10167.4 ERZ97200.1 - 0.17 11.6 2.2 0.2 11.3 1.0 1.5 1 1 0 1 1 1 0 Uncharacterised conserved protein GP41 PF00517.12 ERZ97200.1 - 0.17 11.3 1.2 12 5.3 0.0 2.1 1 1 1 2 2 2 0 Retroviral envelope protein Fib_alpha PF08702.5 ERZ97200.1 - 0.19 11.8 2.6 0.33 11.0 1.8 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.7 ERZ97200.1 - 0.23 11.2 2.0 0.46 10.2 1.4 1.6 1 1 0 1 1 1 0 Laminin Domain II Prefoldin_3 PF13758.1 ERZ97200.1 - 0.33 10.7 4.0 1.4 8.7 2.1 2.1 1 1 1 2 2 2 0 Prefoldin subunit AF0941-like PF14591.1 ERZ97200.1 - 0.37 10.8 5.0 0.67 10.0 3.5 1.6 1 1 0 1 1 1 0 AF0941-like Syntaxin PF00804.20 ERZ97200.1 - 0.43 10.7 3.1 13 5.9 0.4 2.1 1 1 1 2 2 2 0 Syntaxin Tropomyosin_1 PF12718.2 ERZ97200.1 - 0.77 9.5 4.2 3.2 7.6 3.0 1.8 1 1 0 1 1 1 0 Tropomyosin like FlaC_arch PF05377.6 ERZ97200.1 - 2.6 8.0 7.6 5.1 7.0 0.4 2.9 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) A_deamin PF02137.13 ERZ97201.1 - 2.3e-42 145.5 0.3 2.6e-42 145.3 0.2 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain MIR PF02815.14 ERZ97202.1 - 0.00069 19.2 0.1 0.28 10.7 0.0 2.2 1 1 1 2 2 2 2 MIR domain DUF3825 PF12873.2 ERZ97204.1 - 0.025 13.7 0.2 0.03 13.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) Sel1 PF08238.7 ERZ97205.1 - 7.2e-26 90.0 4.3 1.6e-09 38.0 0.2 3.9 3 1 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ERZ97205.1 - 0.0022 18.3 1.5 0.63 10.6 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ97205.1 - 0.0031 17.1 0.1 1.5 8.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97205.1 - 0.012 15.2 6.3 0.35 10.5 0.4 2.7 1 1 2 3 3 3 0 TPR repeat TPR_17 PF13431.1 ERZ97205.1 - 0.034 14.3 4.0 1.4 9.3 0.5 3.4 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.7 ERZ97205.1 - 0.035 13.9 5.0 1.7 8.5 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ERZ97205.1 - 0.058 13.2 1.7 0.78 9.6 0.0 2.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ERZ97205.1 - 0.095 12.6 4.0 7 6.6 0.2 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ97205.1 - 9.7 6.3 11.5 3.5 7.7 0.1 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat IncA PF04156.9 ERZ97207.1 - 1.7 8.1 5.7 0.34 10.4 1.2 1.8 3 0 0 3 3 3 0 IncA protein DUF659 PF04937.10 ERZ97208.1 - 2.3e-11 43.4 0.1 3.9e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) SLX9 PF15341.1 ERZ97210.1 - 0.027 14.9 5.8 0.053 13.9 3.1 2.1 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 DUF4025 PF13217.1 ERZ97213.1 - 0.11 12.2 0.2 0.27 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4025) p450 PF00067.17 ERZ97214.1 - 2.8e-58 197.5 0.2 3.3e-58 197.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 NTP_transferase PF00483.18 ERZ97216.1 - 7.5e-15 54.9 0.0 1.9e-14 53.5 0.0 1.6 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.19 ERZ97216.1 - 8.5e-09 34.5 5.5 0.00011 21.5 0.4 3.9 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 ERZ97216.1 - 4.4e-07 30.1 0.0 5.9e-07 29.7 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.14 ERZ97216.1 - 0.0037 16.9 0.1 0.0097 15.5 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase Thi4 PF01946.12 ERZ97216.1 - 0.026 13.6 0.3 0.045 12.8 0.2 1.3 1 0 0 1 1 1 0 Thi4 family LSM PF01423.17 ERZ97217.1 - 1.9e-21 75.3 0.2 2.2e-21 75.1 0.1 1.0 1 0 0 1 1 1 1 LSM domain UPF0565 PF10561.4 ERZ97217.1 - 0.045 12.6 0.0 0.05 12.4 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 LSM14 PF12701.2 ERZ97217.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Ribosomal_S6 PF01250.12 ERZ97218.1 - 1e-14 54.1 0.0 1.2e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 SET PF00856.23 ERZ97219.1 - 1.3e-10 41.8 0.3 4.5e-10 40.0 0.2 1.8 1 1 0 1 1 1 1 SET domain HypA PF01155.14 ERZ97219.1 - 0.1 12.3 0.2 0.16 11.6 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Sod_Fe_N PF00081.17 ERZ97220.1 - 2.8e-34 117.2 1.1 4.5e-34 116.5 0.8 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Sod_Fe_C PF02777.13 ERZ97220.1 - 3.7e-20 71.7 0.0 6.3e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain HTH_29 PF13551.1 ERZ97221.1 - 0.091 12.9 0.1 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_Tc5 PF03221.11 ERZ97221.1 - 0.14 11.9 0.6 0.37 10.6 0.0 1.9 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ERZ97222.1 - 0.023 13.8 0.2 0.031 13.4 0.1 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_1 PF03184.14 ERZ97223.1 - 1.1e-52 178.3 0.0 1.5e-52 177.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ERZ97223.1 - 0.0001 22.0 0.0 0.00018 21.2 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ97223.1 - 0.045 13.5 0.5 0.11 12.3 0.4 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain F-box-like PF12937.2 ERZ97224.1 - 1.2e-06 28.1 0.3 2.4e-06 27.1 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ97224.1 - 3.1e-05 23.4 0.1 6.9e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain FYVE PF01363.16 ERZ97224.1 - 0.0018 18.1 0.8 0.0042 16.9 0.6 1.6 1 0 0 1 1 1 1 FYVE zinc finger zinc_ribbon_2 PF13240.1 ERZ97224.1 - 0.12 11.9 0.6 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain FdhE PF04216.7 ERZ97224.1 - 4.1 7.0 9.2 0.14 11.8 0.7 2.2 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation Neur_chan_memb PF02932.11 ERZ97224.1 - 9.5 6.0 8.9 15 5.3 6.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.27 ERZ97225.1 - 4e-21 74.0 15.0 2e-05 24.2 0.2 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ERZ97225.1 - 0.016 14.9 0.1 2.7 7.6 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A F-box-like PF12937.2 ERZ97226.1 - 2.8e-06 26.9 4.8 5.9e-06 25.9 1.2 2.7 2 0 0 2 2 2 1 F-box-like Glyco_transf_92 PF01697.22 ERZ97226.1 - 0.029 13.6 0.0 0.4 9.9 0.0 2.5 3 0 0 3 3 3 0 Glycosyltransferase family 92 Nab2 PF11517.3 ERZ97227.1 - 0.041 13.9 0.2 0.087 12.9 0.1 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Arylesterase PF01731.15 ERZ97228.1 - 2.7e-13 49.6 0.2 6.6e-13 48.4 0.1 1.6 1 0 0 1 1 1 1 Arylesterase SGL PF08450.7 ERZ97228.1 - 5.4e-05 22.6 0.0 8.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region HERV-K_env_2 PF13804.1 ERZ97229.1 - 0.032 13.7 0.1 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Retro-transcribing viruses envelope glycoprotein p450 PF00067.17 ERZ97230.1 - 2.7e-73 247.0 0.3 3.5e-73 246.6 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 PRF PF06875.6 ERZ97230.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Sel1 PF08238.7 ERZ97232.1 - 2.9e-152 491.8 53.2 4.1e-12 46.3 0.2 15.1 15 0 0 15 15 15 15 Sel1 repeat Amidase02_C PF12123.3 ERZ97232.1 - 2.4e-08 33.5 5.4 25 4.6 0.0 8.2 9 0 0 9 9 9 0 N-acetylmuramoyl-l-alanine amidase PvlArgDC PF01862.11 ERZ97232.1 - 1.3e-07 31.3 0.2 20 4.7 0.0 8.2 9 1 1 10 10 10 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) TPR_6 PF13174.1 ERZ97232.1 - 0.1 13.1 8.0 23 5.7 0.1 6.4 9 0 0 9 9 9 0 Tetratricopeptide repeat Metallothio_2 PF01439.13 ERZ97232.1 - 3.1 8.4 9.6 44 4.7 0.3 4.5 3 1 1 4 4 4 0 Metallothionein TPR_10 PF13374.1 ERZ97232.1 - 5.2 7.1 9.1 54 3.9 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat F-box-like PF12937.2 ERZ97233.1 - 0.0013 18.4 0.4 0.0031 17.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like Med27 PF11571.3 ERZ97233.1 - 0.024 14.7 0.5 0.54 10.4 0.1 3.0 2 0 0 2 2 2 0 Mediator complex subunit 27 Vps16_N PF04841.8 ERZ97236.1 - 4.3e-109 364.7 0.0 6.8e-109 364.1 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.7 ERZ97236.1 - 8.4e-95 317.3 5.6 1.9e-94 316.2 3.9 1.6 1 0 0 1 1 1 1 Vps16, C-terminal region Nucleoporin_N PF08801.6 ERZ97236.1 - 0.047 12.4 0.0 0.1 11.3 0.0 1.5 1 0 0 1 1 1 0 Nup133 N terminal like DUF1476 PF07345.6 ERZ97236.1 - 0.1 12.8 2.5 0.63 10.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1476) Golgin_A5 PF09787.4 ERZ97236.1 - 0.2 10.1 7.5 3.7 5.9 0.0 2.1 1 1 0 2 2 2 0 Golgin subfamily A member 5 HECT PF00632.20 ERZ97237.1 - 3.9e-38 131.3 1.7 8.4e-38 130.2 1.2 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ribosomal_S19e PF01090.14 ERZ97238.1 - 1.3e-59 199.6 0.1 1.4e-59 199.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e PC_rep PF01851.17 ERZ97239.1 - 1.8e-44 147.4 12.5 3.7e-08 33.1 0.0 10.5 11 0 0 11 11 11 8 Proteasome/cyclosome repeat HEAT_2 PF13646.1 ERZ97239.1 - 1.7e-17 63.4 0.7 1.5e-11 44.4 0.0 4.4 2 1 3 5 5 5 3 HEAT repeats HEAT PF02985.17 ERZ97239.1 - 1.4e-07 30.9 0.2 0.42 10.8 0.1 4.3 3 0 0 3 3 3 3 HEAT repeat HEAT_EZ PF13513.1 ERZ97239.1 - 3.8e-07 30.3 0.7 0.11 13.0 0.0 4.8 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.18 ERZ97239.1 - 0.0097 15.7 0.1 9.1 6.2 0.0 3.7 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.11 ERZ97239.1 - 0.032 14.6 1.8 20 5.9 0.0 4.5 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat DUF3279 PF11682.3 ERZ97240.1 - 0.0072 15.8 1.5 0.0085 15.6 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3279) DUF3450 PF11932.3 ERZ97240.1 - 0.018 14.2 0.1 0.024 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) zf-B_box PF00643.19 ERZ97240.1 - 0.023 14.5 4.0 0.038 13.8 2.8 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF3916 PF13079.1 ERZ97242.1 - 0.00028 20.5 1.2 0.002 17.7 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3916) DUF1911 PF08929.5 ERZ97242.1 - 0.21 12.2 0.1 0.21 12.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) Pkinase_Tyr PF07714.12 ERZ97245.1 - 1.3e-11 44.0 0.0 1.6e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97245.1 - 2.7e-09 36.5 0.0 3.7e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Exo_endo_phos PF03372.18 ERZ97246.1 - 5e-10 39.7 0.0 9.9e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ERZ97246.1 - 1.1e-09 37.9 0.7 1.1e-09 37.9 0.5 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RNase_H PF00075.19 ERZ97246.1 - 6.6e-07 29.7 0.2 2.9e-06 27.6 0.1 2.1 1 0 0 1 1 1 1 RNase H RRM_1 PF00076.17 ERZ97247.1 - 8.3e-06 25.3 0.1 0.00013 21.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ97247.1 - 0.00015 21.6 0.0 0.0024 17.8 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FYVE PF01363.16 ERZ97250.1 - 1.7e-15 56.6 6.3 1.7e-15 56.6 4.4 2.4 2 0 0 2 2 2 1 FYVE zinc finger DUF4407 PF14362.1 ERZ97250.1 - 0.0037 16.2 0.4 0.0037 16.2 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) zf-AN1 PF01428.11 ERZ97250.1 - 0.012 15.4 6.8 0.05 13.4 4.7 2.1 1 0 0 1 1 1 0 AN1-like Zinc finger DUF948 PF06103.6 ERZ97250.1 - 1.5 8.7 6.1 2 8.3 1.6 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Patatin PF01734.17 ERZ97251.1 - 9.2e-20 71.4 0.1 7.2e-19 68.5 0.0 2.3 2 0 0 2 2 2 1 Patatin-like phospholipase TPR_19 PF14559.1 ERZ97251.1 - 3.1e-05 24.2 8.0 8.9e-05 22.7 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97251.1 - 0.00012 21.6 24.8 0.0042 16.7 0.1 5.8 4 1 2 6 6 6 3 TPR repeat Fis1_TPR_C PF14853.1 ERZ97251.1 - 0.0016 18.2 0.8 0.019 14.8 0.5 3.1 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 ERZ97251.1 - 0.0032 17.5 0.3 0.0032 17.5 0.2 5.3 3 1 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ERZ97251.1 - 0.011 16.3 0.2 0.083 13.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ97251.1 - 0.061 13.2 19.8 0.044 13.7 0.8 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ97251.1 - 0.36 10.7 14.7 0.054 13.2 2.8 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3318 PF11780.3 ERZ97251.1 - 0.83 9.2 2.6 1.8 8.1 1.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3318) TPR_17 PF13431.1 ERZ97251.1 - 1.1 9.6 9.3 0.67 10.2 0.1 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat CCDC66 PF15236.1 ERZ97252.1 - 7.4 6.1 18.7 11 5.6 12.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Poxvirus_B22R PF04395.7 ERZ97253.1 - 0.17 11.3 4.8 0.064 12.7 1.3 1.8 2 0 0 2 2 2 0 Poxvirus B22R protein Triabin PF03973.8 ERZ97257.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Triabin Phage_tail_S PF05069.8 ERZ97257.1 - 0.13 11.9 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Phage virion morphogenesis family BRF1 PF07741.8 ERZ97261.1 - 5 7.4 6.1 18 5.6 0.1 2.9 2 1 1 3 3 3 0 Brf1-like TBP-binding domain Astacin PF01400.19 ERZ97262.1 - 2e-07 30.6 0.0 3.7e-07 29.7 0.0 1.6 1 1 1 2 2 2 1 Astacin (Peptidase family M12A) Pkinase_Tyr PF07714.12 ERZ97264.1 - 3.4e-37 127.9 0.0 4.9e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97264.1 - 1.7e-36 125.6 0.0 3e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF1048 PF06304.6 ERZ97264.1 - 0.026 14.8 0.4 0.33 11.2 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1048) Pkinase_Tyr PF07714.12 ERZ97265.1 - 3e-32 111.7 0.0 2.5e-21 75.9 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ97265.1 - 8.3e-32 110.3 0.2 3.1e-30 105.1 0.2 2.3 1 1 0 1 1 1 1 Protein kinase domain Bromodomain PF00439.20 ERZ97266.1 - 5.3e-15 55.1 0.3 5.6e-15 55.0 0.2 1.0 1 0 0 1 1 1 1 Bromodomain PUB PF09409.5 ERZ97270.1 - 0.18 11.5 0.8 22 4.9 0.0 3.1 2 1 1 3 3 3 0 PUB domain MULE PF10551.4 ERZ97272.1 - 8.8e-08 32.2 0.1 3e-07 30.5 0.0 1.9 2 1 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.13 ERZ97272.1 - 0.00054 18.6 0.0 0.00064 18.3 0.0 1.2 1 0 0 1 1 1 1 Transposase, Mutator family NIL PF09383.5 ERZ97272.1 - 0.049 13.2 0.0 0.08 12.5 0.0 1.3 1 0 0 1 1 1 0 NIL domain Pkinase_Tyr PF07714.12 ERZ97274.1 - 9.2e-33 113.4 0.2 1.5e-32 112.7 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97274.1 - 1.6e-31 109.4 0.1 2.9e-31 108.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ97274.1 - 0.0031 16.6 0.5 0.013 14.5 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97274.1 - 0.0097 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family PYST-C1 PF09690.5 ERZ97277.1 - 0.0069 15.9 3.8 0.015 14.9 2.6 1.5 1 0 0 1 1 1 1 Plasmodium yoelii subtelomeric region (PYST-C1) VIT1 PF01988.14 ERZ97278.1 - 5.3e-48 163.3 0.4 5.3e-48 163.3 0.3 1.4 2 0 0 2 2 2 1 VIT family UDP-g_GGTase PF06427.6 ERZ97278.1 - 0.042 13.1 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose:Glycoprotein Glucosyltransferase Sel1 PF08238.7 ERZ97280.1 - 6.1e-26 90.2 4.0 1.2e-12 48.0 0.2 3.0 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ERZ97280.1 - 0.00013 22.2 0.8 0.38 11.3 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97280.1 - 0.014 15.5 0.5 7.2 7.0 0.0 3.1 2 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ERZ97280.1 - 0.028 14.3 4.4 0.21 11.4 2.9 2.2 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain Apc3 PF12895.2 ERZ97280.1 - 0.093 12.8 0.6 5 7.3 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ERZ97280.1 - 0.54 9.9 5.2 1.2 8.8 0.8 2.4 1 1 1 2 2 2 0 TPR repeat TPR_2 PF07719.12 ERZ97280.1 - 2.1 8.4 9.3 11 6.1 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat NOP5NT PF08156.8 ERZ97281.1 - 0.067 13.3 0.9 0.067 13.3 0.6 3.7 2 1 1 3 3 3 0 NOP5NT (NUC127) domain CCDC155 PF14662.1 ERZ97281.1 - 1.4 8.4 54.0 0.14 11.7 11.6 2.8 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 LRR_4 PF12799.2 ERZ97281.1 - 1.6 8.4 18.7 3.5 7.3 3.5 3.8 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Reo_sigmaC PF04582.7 ERZ97281.1 - 2.4 7.2 8.0 6 5.9 1.4 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Crystall_3 PF08964.5 ERZ97285.1 - 0.064 12.9 0.3 0.15 11.8 0.2 1.6 1 1 0 1 1 1 0 Beta/Gamma crystallin SCF PF02404.10 ERZ97287.1 - 0.034 13.3 0.3 0.039 13.1 0.2 1.0 1 0 0 1 1 1 0 Stem cell factor DDE_3 PF13358.1 ERZ97288.1 - 9.8e-05 22.1 0.0 9.8e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF237 PF03072.9 ERZ97289.1 - 0.031 14.1 0.6 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 MG032/MG096/MG288 family 1 Pkinase_Tyr PF07714.12 ERZ97290.1 - 4.4e-14 52.1 0.0 8.1e-14 51.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97290.1 - 2.6e-13 49.7 0.0 6.6e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain zf-C3HC4_2 PF13923.1 ERZ97291.1 - 0.0036 17.2 3.3 0.016 15.2 2.3 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF3895 PF13034.1 ERZ97291.1 - 0.047 13.1 0.7 2.3 7.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3895) zf-C3HC4 PF00097.20 ERZ97291.1 - 0.061 12.9 2.2 0.28 10.8 1.8 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ97291.1 - 0.22 11.2 4.1 0.38 10.4 2.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.1 ERZ97291.1 - 0.31 10.7 8.4 0.68 9.7 5.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DZR PF12773.2 ERZ97291.1 - 1.1 9.1 4.4 3.7 7.4 3.1 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_5 PF14634.1 ERZ97291.1 - 1.5 8.6 6.7 2.8 7.7 4.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-BED PF02892.10 ERZ97291.1 - 2.5 7.9 6.7 6.8 6.5 0.6 2.7 2 0 0 2 2 2 0 BED zinc finger zf-RING_2 PF13639.1 ERZ97291.1 - 2.8 7.8 7.4 6.7 6.6 5.1 1.7 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.24 ERZ97291.1 - 5.3 6.8 9.4 18 5.1 6.5 1.9 1 1 0 1 1 1 0 PHD-finger Laminin_G_3 PF13385.1 ERZ97292.1 - 9.3e-16 58.4 0.1 1.7e-15 57.6 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ERZ97292.1 - 1.9e-08 34.0 0.3 0.00013 21.5 0.0 2.8 2 1 0 2 2 2 1 MIR domain Ins145_P3_rec PF08709.6 ERZ97292.1 - 1.1e-05 24.5 0.1 2e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Laminin_G_2 PF02210.19 ERZ97292.1 - 0.033 14.2 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain Asp PF00026.18 ERZ97293.1 - 4.8e-54 183.7 0.6 5.5e-54 183.5 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 ERZ97293.1 - 2.2e-06 27.3 0.1 8.5e-06 25.4 0.0 2.0 3 0 0 3 3 3 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 ERZ97293.1 - 0.0001 22.2 0.0 0.00029 20.8 0.0 1.8 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.18 ERZ97294.1 - 1.4e-06 27.8 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 ERZ97294.1 - 0.0031 17.0 0.0 0.0032 17.0 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Apolipoprotein PF01442.13 ERZ97295.1 - 0.013 15.0 5.5 0.013 15.0 3.8 2.7 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.7 ERZ97295.1 - 1.5 8.6 37.8 0.35 10.6 5.0 3.9 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) DUF2304 PF10066.4 ERZ97295.1 - 5.2 6.9 5.6 1.8 8.4 1.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) LRR_4 PF12799.2 ERZ97296.1 - 4.5e-07 29.3 4.8 0.0058 16.2 0.3 2.9 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ97296.1 - 0.035 14.1 4.4 5.6 7.4 0.0 3.7 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_7 PF13504.1 ERZ97296.1 - 0.064 13.4 0.1 69 4.3 0.0 3.8 3 0 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 ERZ97296.1 - 0.11 12.6 2.1 12 6.3 0.0 3.5 2 1 0 2 2 2 0 Leucine Rich repeat Pkinase_Tyr PF07714.12 ERZ97297.1 - 5.5e-42 143.6 0.1 6.6e-42 143.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97297.1 - 1.4e-38 132.5 1.7 1.7e-38 132.2 1.2 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF3636 PF12331.3 ERZ97298.1 - 0.043 13.3 0.6 0.099 12.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) TPR_1 PF00515.23 ERZ97299.1 - 7e-08 31.7 1.6 3.3e-06 26.4 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ97299.1 - 9.8e-07 28.1 0.4 1.8e-05 24.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ97299.1 - 2e-06 27.1 0.2 0.00013 21.4 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97299.1 - 2e-06 27.3 1.0 2.2e-05 23.9 0.2 2.5 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 ERZ97299.1 - 1.2e-05 25.8 0.2 7.6e-05 23.2 0.0 2.3 3 1 0 3 3 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97299.1 - 1.4e-05 25.1 4.5 0.0051 16.9 0.2 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ERZ97299.1 - 6.3e-05 22.5 0.5 6.3e-05 22.5 0.3 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97299.1 - 0.00029 20.7 1.2 0.00029 20.7 0.9 2.5 2 2 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ERZ97299.1 - 0.0005 19.8 1.1 0.13 12.1 0.0 3.5 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ERZ97299.1 - 0.001 19.4 0.7 0.0082 16.5 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97299.1 - 0.0026 18.2 0.5 0.016 15.7 0.2 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ97299.1 - 0.0037 17.1 0.7 0.012 15.4 0.4 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97299.1 - 0.005 16.9 0.4 0.029 14.5 0.0 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ERZ97299.1 - 0.015 15.5 0.2 0.78 9.9 0.0 2.5 1 1 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_19 PF14559.1 ERZ97299.1 - 0.018 15.3 2.4 0.1 12.9 0.4 2.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ97299.1 - 0.023 14.5 0.1 0.068 13.0 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PWI PF01480.12 ERZ97299.1 - 1.5 8.9 5.1 0.91 9.6 0.4 2.5 2 1 0 2 2 2 0 PWI domain Mg_trans_NIPA PF05653.9 ERZ97300.1 - 6.2e-109 363.5 12.7 8e-109 363.2 8.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 ERZ97300.1 - 4.7e-10 39.6 1.0 4.7e-10 39.6 0.7 2.8 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ERZ97300.1 - 7.4e-08 32.4 25.6 2.9e-07 30.5 2.7 2.8 3 1 0 3 3 3 2 EamA-like transporter family Vma12 PF11712.3 ERZ97300.1 - 1.2 8.8 4.8 1 9.0 0.5 2.3 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Yip1 PF04893.12 ERZ97300.1 - 2.9 7.3 20.7 0.13 11.7 5.3 3.0 1 1 2 3 3 3 0 Yip1 domain EXS PF03124.9 ERZ97301.1 - 5.5e-84 282.1 23.6 1e-83 281.2 16.4 1.4 1 1 0 1 1 1 1 EXS family DNA_pol3_a_NII PF11490.3 ERZ97303.1 - 0.13 11.8 2.6 0.11 12.0 0.5 1.9 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Pkinase PF00069.20 ERZ97304.1 - 1.6e-53 181.4 0.0 1.9e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97304.1 - 2.4e-24 85.8 0.0 4.7e-24 84.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ97304.1 - 0.00017 20.6 0.0 0.00036 19.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ERZ97304.1 - 0.14 11.5 0.2 0.27 10.5 0.2 1.6 1 1 0 1 1 1 0 RIO1 family ATP-synt_ab PF00006.20 ERZ97305.1 - 6.6e-62 208.8 0.0 1.1e-61 208.0 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ERZ97305.1 - 1.2e-16 61.1 0.8 2.8e-16 59.9 0.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ERZ97305.1 - 9.3e-11 41.7 0.2 2e-10 40.6 0.2 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 ERZ97305.1 - 0.0018 18.1 0.1 0.0041 16.9 0.1 1.7 1 0 0 1 1 1 1 HAS barrel domain RdRP PF05183.7 ERZ97306.1 - 2.6e-175 584.4 1.6 3.3e-175 584.1 1.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Lyase_1 PF00206.15 ERZ97307.1 - 6.7e-102 340.8 0.0 1.1e-101 340.1 0.0 1.4 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 ERZ97307.1 - 5.7e-27 93.5 0.1 1.2e-26 92.5 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Mito_carr PF00153.22 ERZ97308.1 - 5.4e-74 243.9 0.5 5e-24 83.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Colicin_V PF02674.11 ERZ97308.1 - 0.086 12.6 0.9 2.5 7.9 0.1 2.9 3 0 0 3 3 3 0 Colicin V production protein Bestrophin PF01062.16 ERZ97310.1 - 1.6e-51 174.9 1.8 3e-50 170.8 1.3 2.0 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel ELMO_CED12 PF04727.8 ERZ97310.1 - 0.0022 17.5 0.1 0.0036 16.8 0.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family HEAT PF02985.17 ERZ97311.1 - 1.3e-06 28.0 0.0 0.01 15.8 0.0 4.2 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 ERZ97311.1 - 0.00083 19.5 0.0 0.054 13.7 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats Cohesin_HEAT PF12765.2 ERZ97311.1 - 0.0053 16.6 0.2 1.4 8.9 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion DUF2435 PF10363.4 ERZ97311.1 - 0.011 15.6 0.0 1 9.2 0.0 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2435) Atx10homo_assoc PF09759.4 ERZ97311.1 - 0.077 12.7 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Proteasom_PSMB PF10508.4 ERZ97312.1 - 0.00057 18.2 1.9 0.038 12.2 0.2 2.8 1 1 2 3 3 3 2 Proteasome non-ATPase 26S subunit Drf_GBD PF06371.8 ERZ97312.1 - 0.033 13.5 0.5 0.075 12.3 0.1 1.8 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain DUF3510 PF12022.3 ERZ97312.1 - 0.13 12.4 0.5 0.47 10.5 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) Ribosomal_S13_N PF08069.7 ERZ97313.1 - 1.2e-29 101.9 0.1 2.2e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 ERZ97313.1 - 1.2e-20 73.0 0.7 2e-20 72.3 0.3 1.4 2 0 0 2 2 2 1 Ribosomal protein S15 PAX PF00292.13 ERZ97313.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 'Paired box' domain DUF866 PF05907.8 ERZ97314.1 - 7e-56 188.1 0.0 7.7e-56 188.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) DUF581 PF04570.9 ERZ97314.1 - 0.019 14.2 0.3 0.22 10.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF581) Tim44 PF04280.10 ERZ97315.1 - 0.0047 16.9 0.1 0.0094 15.9 0.0 1.5 2 0 0 2 2 2 1 Tim44-like domain ALAD PF00490.16 ERZ97316.1 - 1.4e-122 408.6 0.0 1.6e-122 408.4 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Pex24p PF06398.6 ERZ97317.1 - 3.2e-45 154.4 17.9 3.2e-45 154.4 12.4 1.7 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin Reo_sigmaC PF04582.7 ERZ97318.1 - 0.00062 19.0 1.9 0.00085 18.5 1.3 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 ERZ97318.1 - 0.00093 17.0 1.2 0.0012 16.7 0.8 1.1 1 0 0 1 1 1 1 Myosin tail APG6 PF04111.7 ERZ97318.1 - 0.02 13.9 5.1 0.036 13.1 3.5 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF16 PF01519.11 ERZ97318.1 - 0.023 14.8 0.7 0.023 14.8 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Tropomyosin PF00261.15 ERZ97318.1 - 0.047 12.7 1.3 0.083 11.9 0.9 1.3 1 0 0 1 1 1 0 Tropomyosin DUF489 PF04356.7 ERZ97318.1 - 0.14 11.7 3.5 0.21 11.1 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF3086 PF11285.3 ERZ97318.1 - 0.33 9.7 3.1 0.29 9.9 0.9 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3086) IncA PF04156.9 ERZ97318.1 - 0.4 10.2 2.0 0.54 9.8 1.4 1.2 1 0 0 1 1 1 0 IncA protein TBPIP PF07106.8 ERZ97318.1 - 0.43 10.1 9.1 0.026 14.0 2.7 1.6 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NPV_P10 PF05531.7 ERZ97318.1 - 1 9.6 4.8 13 6.0 3.3 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein V_ATPase_I PF01496.14 ERZ97318.1 - 1.4 6.7 8.3 0.22 9.3 2.2 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family HAP2-GCS1 PF10699.4 ERZ97319.1 - 0.098 12.6 0.1 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Male gamete fusion factor DUF2499 PF10693.4 ERZ97320.1 - 0.014 15.4 2.2 0.025 14.5 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2499) Pkinase_Tyr PF07714.12 ERZ97322.1 - 1.1e-40 139.4 0.0 1.3e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97322.1 - 3.4e-39 134.5 0.9 6.7e-39 133.5 0.6 1.4 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ERZ97322.1 - 0.0059 16.2 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal Yippee-Mis18 PF03226.9 ERZ97324.1 - 0.018 15.1 0.1 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Prp18 PF02840.10 ERZ97325.1 - 0.015 15.1 0.1 0.047 13.4 0.0 1.7 2 0 0 2 2 2 0 Prp18 domain BCS1_N PF08740.6 ERZ97325.1 - 0.063 12.8 0.0 0.26 10.8 0.0 1.9 2 0 0 2 2 2 0 BCS1 N terminal MAT1 PF06391.8 ERZ97325.1 - 0.34 10.4 3.6 4.6 6.7 0.4 2.2 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF2417 PF10329.4 ERZ97326.1 - 0.019 14.3 0.3 0.037 13.4 0.2 1.5 1 0 0 1 1 1 0 Region of unknown function (DUF2417) IspA PF04279.10 ERZ97326.1 - 0.24 11.3 12.1 0.47 10.3 0.5 2.1 2 0 0 2 2 2 0 Intracellular septation protein A Claudin_2 PF13903.1 ERZ97328.1 - 0.028 14.1 2.5 0.054 13.1 0.0 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4149 PF13664.1 ERZ97328.1 - 6.1 6.9 8.0 1.8 8.6 0.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF4149) zf-C2H2 PF00096.21 ERZ97329.1 - 2.1e-21 74.8 70.5 0.0024 18.0 0.4 9.1 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ERZ97329.1 - 2.5e-21 74.8 65.6 0.0002 21.5 1.0 9.9 10 0 0 10 10 10 7 Zinc-finger double domain zf-C2H2_4 PF13894.1 ERZ97329.1 - 1.1e-17 62.9 60.9 0.014 15.6 0.1 9.1 9 0 0 9 9 9 7 C2H2-type zinc finger TLD PF07534.11 ERZ97331.1 - 6.1e-16 58.6 0.5 6.1e-16 58.6 0.3 3.5 4 0 0 4 4 4 1 TLD BTB PF00651.26 ERZ97331.1 - 1e-15 57.6 1.4 2.7e-15 56.3 0.9 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ97331.1 - 2e-06 27.5 3.9 0.00026 20.7 0.4 3.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch Urm1 PF09138.6 ERZ97331.1 - 0.0026 17.8 0.5 0.72 10.0 0.0 2.9 2 0 0 2 2 2 2 Urm1 (Ubiquitin related modifier) CBM_X PF06204.6 ERZ97332.1 - 0.021 14.3 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative carbohydrate binding domain SEA PF01390.15 ERZ97333.1 - 0.007 16.0 0.0 0.29 10.8 0.0 2.6 2 0 0 2 2 2 1 SEA domain SAM_PNT PF02198.11 ERZ97333.1 - 0.047 13.4 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain ETRAMP PF09716.5 ERZ97334.1 - 0.018 14.9 1.4 0.034 14.0 1.0 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DNA_ligase_A_M PF01068.16 ERZ97335.1 - 6.9e-56 188.8 1.3 1.4e-55 187.8 0.9 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 ERZ97335.1 - 9.2e-52 175.4 0.4 9.2e-52 175.4 0.2 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 ERZ97335.1 - 3.5e-27 94.6 0.0 9.9e-27 93.2 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 ERZ97335.1 - 0.004 16.7 0.1 0.98 9.1 0.0 2.5 2 0 0 2 2 2 2 DNA ligase OB-like domain Tim54 PF11711.3 ERZ97336.1 - 3.8e-51 173.8 0.0 9.2e-50 169.3 0.0 2.1 1 1 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 GAS PF13851.1 ERZ97337.1 - 0.059 12.5 0.2 0.098 11.8 0.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Pkinase PF00069.20 ERZ97340.1 - 2.6e-45 154.6 0.2 3.2e-45 154.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97340.1 - 3e-41 141.2 0.0 3.6e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ97340.1 - 0.00019 20.4 0.0 0.011 14.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ERZ97340.1 - 0.00035 19.9 0.4 0.0009 18.6 0.0 1.7 2 0 0 2 2 2 1 RIO1 family WaaY PF06176.6 ERZ97340.1 - 0.0014 17.9 0.3 0.0021 17.3 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ERZ97340.1 - 0.0035 16.4 0.0 0.0055 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97340.1 - 0.0041 16.8 0.1 0.85 9.3 0.6 2.8 1 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ97341.1 - 1.6e-12 47.0 0.0 2e-12 46.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97341.1 - 3.4e-08 32.9 0.0 4.4e-08 32.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97342.1 - 3.4e-18 65.6 0.0 3.6e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97342.1 - 3.9e-18 65.5 0.1 4.1e-18 65.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ERZ97342.1 - 0.00085 18.7 0.0 0.00093 18.5 0.0 1.0 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ97342.1 - 0.035 13.1 0.0 0.035 13.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97342.1 - 0.12 12.0 0.1 0.16 11.6 0.1 1.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family TLD PF07534.11 ERZ97343.1 - 3.6e-09 36.7 1.9 3.6e-09 36.7 1.3 2.3 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ97343.1 - 0.0041 16.9 1.9 0.01 15.6 0.8 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ97343.1 - 0.03 14.3 0.1 0.072 13.0 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain Pox_polyA_pol_N PF12630.2 ERZ97344.1 - 0.2 11.7 5.1 0.068 13.2 1.1 1.9 1 1 1 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain IncA PF04156.9 ERZ97345.1 - 0.051 13.1 0.0 0.071 12.6 0.0 1.2 1 0 0 1 1 1 0 IncA protein BRE1 PF08647.6 ERZ97345.1 - 0.079 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Imm25 PF15571.1 ERZ97346.1 - 0.03 14.4 0.6 0.057 13.5 0.3 1.5 1 1 0 1 1 1 0 Immunity protein 25 LRR_6 PF13516.1 ERZ97346.1 - 5.1 7.4 9.9 5.2 7.4 1.0 3.8 4 1 0 4 4 4 0 Leucine Rich repeat HTH_45 PF14947.1 ERZ97347.1 - 0.029 14.1 0.2 0.12 12.1 0.2 2.2 1 0 0 1 1 1 0 Winged helix-turn-helix Terminase_2 PF03592.11 ERZ97347.1 - 1.1 9.5 5.6 0.63 10.3 0.8 2.3 2 0 0 2 2 2 0 Terminase small subunit DUF3760 PF12586.3 ERZ97349.1 - 0.038 13.8 0.5 12 5.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) Endotoxin_C PF03944.9 ERZ97350.1 - 0.012 15.7 0.0 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 delta endotoxin RNA_bind_2 PF10133.4 ERZ97350.1 - 0.13 12.3 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Predicted RNA-binding protein E1-E2_ATPase PF00122.15 ERZ97351.1 - 1.5e-22 79.7 0.0 4.6e-22 78.1 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ERZ97351.1 - 9e-22 78.5 0.0 2.9e-21 76.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ERZ97351.1 - 7.6e-20 71.8 0.0 2.1e-19 70.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ERZ97351.1 - 1.2e-06 28.3 0.0 2.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ERZ97351.1 - 0.0031 17.1 0.0 0.0099 15.4 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 ERZ97351.1 - 0.031 13.5 0.0 0.44 9.8 0.0 2.5 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Robl_LC7 PF03259.12 ERZ97352.1 - 0.0015 18.0 0.1 0.0059 16.1 0.0 1.8 1 1 0 1 1 1 1 Roadblock/LC7 domain Glyco_hydro_31 PF01055.21 ERZ97353.1 - 9.7e-158 525.5 4.2 1.2e-157 525.2 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 ERZ97353.1 - 7.8e-21 73.7 0.0 3.5e-20 71.6 0.0 2.2 1 0 0 1 1 1 1 Galactose mutarotase-like Anp1 PF03452.9 ERZ97354.1 - 0.025 13.7 2.2 0.37 9.9 0.3 2.6 1 1 1 2 2 2 0 Anp1 Nbs1_C PF08599.5 ERZ97357.1 - 0.49 10.3 3.5 1.9 8.4 0.8 2.7 2 1 0 2 2 2 0 DNA damage repair protein Nbs1 TLD PF07534.11 ERZ97358.1 - 6e-13 48.9 1.5 1.3e-12 47.8 1.1 1.6 1 1 0 1 1 1 1 TLD BTB PF00651.26 ERZ97360.1 - 6.3e-11 42.2 0.0 1.3e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97360.1 - 7.7e-10 38.9 0.2 7.7e-10 38.9 0.1 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ97360.1 - 0.00044 20.0 1.1 0.0025 17.5 0.3 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch RasGEF_N PF00618.15 ERZ97360.1 - 0.034 14.2 0.4 0.034 14.2 0.2 2.4 1 1 1 2 2 2 0 RasGEF N-terminal motif BTB PF00651.26 ERZ97361.1 - 1.1e-20 73.6 0.0 1.9e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97361.1 - 1.2e-14 54.5 2.8 5.5e-14 52.3 1.5 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ97361.1 - 0.0028 17.4 3.6 0.024 14.4 0.4 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch CDtoxinA PF03498.9 ERZ97363.1 - 0.018 14.4 0.6 0.025 13.9 0.4 1.2 1 0 0 1 1 1 0 Cytolethal distending toxin A/C family Pkinase_Tyr PF07714.12 ERZ97363.1 - 0.12 11.4 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF3931 PF13082.1 ERZ97364.1 - 0.056 13.3 1.2 2 8.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3931) CD34_antigen PF06365.7 ERZ97364.1 - 0.062 12.9 0.2 0.081 12.5 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Prefoldin_3 PF13758.1 ERZ97365.1 - 0.076 12.8 0.2 0.098 12.4 0.1 1.4 1 1 0 1 1 1 0 Prefoldin subunit GBP_repeat PF02526.9 ERZ97365.1 - 0.12 11.8 0.6 0.18 11.2 0.1 1.6 2 0 0 2 2 2 0 Glycophorin-binding protein Imm25 PF15571.1 ERZ97366.1 - 0.74 9.9 5.9 18 5.4 0.1 3.7 2 2 2 4 4 4 0 Immunity protein 25 DUF4452 PF14618.1 ERZ97366.1 - 2.2 8.0 9.2 5 6.9 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4452) DUF2816 PF10992.3 ERZ97366.1 - 4.5 6.9 12.2 10 5.8 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2816) Aldo_ket_red PF00248.16 ERZ97367.1 - 1.3e-14 53.7 0.0 1.5e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3782 PF12644.2 ERZ97367.1 - 0.077 12.7 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) RHH_3 PF12651.2 ERZ97367.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix domain Aldo_ket_red PF00248.16 ERZ97368.1 - 9.1e-49 165.7 0.0 1.6e-48 164.9 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Myb_DNA-bind_6 PF13921.1 ERZ97368.1 - 0.072 13.2 0.1 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain Aldo_ket_red PF00248.16 ERZ97369.1 - 3.6e-30 104.7 0.0 4.2e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TLD PF07534.11 ERZ97372.1 - 3.7e-12 46.4 1.6 4.9e-12 46.0 1.1 1.2 1 0 0 1 1 1 1 TLD IGPS PF00218.16 ERZ97373.1 - 2.2e-94 315.2 0.2 3.5e-94 314.6 0.1 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.17 ERZ97373.1 - 3.7e-55 186.5 0.0 1.9e-52 177.6 0.0 2.3 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.23 ERZ97373.1 - 1.4e-51 174.7 0.0 2.6e-51 173.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ERZ97373.1 - 1.2e-05 24.9 0.5 5.2e-05 22.7 0.4 2.1 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.14 ERZ97373.1 - 0.0043 16.6 1.9 0.12 11.9 0.1 2.9 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain DUF2316 PF10078.4 ERZ97373.1 - 0.075 13.0 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) FMN_dh PF01070.13 ERZ97373.1 - 0.16 10.7 0.1 0.52 9.1 0.0 1.8 2 0 0 2 2 2 0 FMN-dependent dehydrogenase HlyD_3 PF13437.1 ERZ97376.1 - 0.056 13.7 0.6 0.11 12.8 0.2 1.6 1 1 1 2 2 2 0 HlyD family secretion protein fn3_3 PF14686.1 ERZ97376.1 - 0.09 12.9 0.2 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II TLD PF07534.11 ERZ97377.1 - 5.3e-06 26.4 0.3 1e-05 25.5 0.2 1.5 1 1 0 1 1 1 1 TLD BTB PF00651.26 ERZ97378.1 - 9.1e-19 67.4 0.1 1.6e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain STAS PF01740.16 ERZ97378.1 - 0.077 12.4 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 STAS domain Pro_3_hydrox_C PF05373.6 ERZ97379.1 - 0.074 13.0 0.6 11 6.1 0.1 2.4 2 1 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal UPF0489 PF12640.2 ERZ97379.1 - 0.076 13.2 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 UPF0489 domain IU_nuc_hydro PF01156.14 ERZ97380.1 - 9.2e-57 192.6 0.1 2.8e-55 187.7 0.0 2.6 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase zf-HC5HC2H_2 PF13832.1 ERZ97381.1 - 7.6e-34 116.0 12.6 7.6e-34 116.0 8.8 2.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 ERZ97381.1 - 1.5e-25 89.1 10.8 1.5e-25 89.1 7.5 3.1 3 0 0 3 3 3 1 PHD-like zinc-binding domain EPL1 PF10513.4 ERZ97381.1 - 3.7e-24 85.7 7.6 3.7e-24 85.7 5.3 4.0 2 1 1 4 4 4 1 Enhancer of polycomb-like Bromodomain PF00439.20 ERZ97381.1 - 2.2e-19 69.1 0.1 6.8e-19 67.5 0.1 1.9 1 0 0 1 1 1 1 Bromodomain PHD_2 PF13831.1 ERZ97381.1 - 1.1e-14 53.4 2.8 1.1e-14 53.4 1.9 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 ERZ97381.1 - 8.8e-09 34.9 8.8 8.8e-09 34.9 6.1 2.8 3 0 0 3 3 3 1 PHD-finger C1_1 PF00130.17 ERZ97381.1 - 6.2 6.6 24.7 0.021 14.5 1.0 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NOT2_3_5 PF04153.13 ERZ97382.1 - 0.018 14.9 0.7 0.042 13.7 0.5 1.5 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family MFS_1 PF07690.11 ERZ97384.1 - 9e-40 136.4 28.1 9e-40 136.4 19.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MULE PF10551.4 ERZ97385.1 - 0.00022 21.3 0.1 0.00075 19.6 0.0 1.9 3 0 0 3 3 3 1 MULE transposase domain HycA_repressor PF11046.3 ERZ97385.1 - 0.042 13.7 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Transcriptional repressor of hyc and hyp operons zf-RING_5 PF14634.1 ERZ97387.1 - 6.8e-09 35.3 15.2 0.00025 20.7 3.3 2.6 2 0 0 2 2 2 2 zinc-RING finger domain zf-rbx1 PF12678.2 ERZ97387.1 - 8.5e-08 32.2 6.0 0.00022 21.2 0.3 2.6 2 0 0 2 2 2 2 RING-H2 zinc finger zf-RING_2 PF13639.1 ERZ97387.1 - 5.8e-07 29.2 19.9 0.00011 21.9 3.6 2.8 2 1 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.1 ERZ97387.1 - 0.00023 21.1 22.5 0.0012 18.8 4.4 3.1 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ERZ97387.1 - 0.00046 19.7 17.7 0.02 14.5 2.9 3.3 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Ribosomal_S27e PF01667.12 ERZ97387.1 - 0.0064 16.0 0.9 1.7 8.2 0.0 2.5 2 0 0 2 2 2 2 Ribosomal protein S27 Lysozyme_like PF13702.1 ERZ97387.1 - 0.011 15.2 0.1 0.018 14.5 0.1 1.3 1 0 0 1 1 1 0 Lysozyme-like zf-RING_UBOX PF13445.1 ERZ97387.1 - 0.017 14.8 1.0 0.017 14.8 0.7 3.4 3 0 0 3 3 3 0 RING-type zinc-finger zf-Apc11 PF12861.2 ERZ97387.1 - 0.12 12.2 4.6 2.4 8.0 0.3 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger mRNA_cap_C PF03919.10 ERZ97387.1 - 0.16 12.2 1.3 2.4 8.5 0.5 2.3 1 1 1 2 2 2 0 mRNA capping enzyme, C-terminal domain Pkinase_Tyr PF07714.12 ERZ97389.1 - 4.7e-36 124.1 0.0 8.5e-36 123.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97389.1 - 2.7e-35 121.8 0.1 5.4e-35 120.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ97389.1 - 0.0023 17.0 0.1 0.0043 16.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97389.1 - 0.017 14.8 0.1 0.026 14.2 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MreB_Mbl PF06723.8 ERZ97390.1 - 0.014 14.0 0.0 1.3 7.5 0.0 2.6 2 1 0 2 2 2 0 MreB/Mbl protein BTB PF00651.26 ERZ97391.1 - 6e-12 45.5 0.9 9.8e-12 44.8 0.2 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ97391.1 - 1.5e-07 31.4 1.7 1.2e-06 28.5 1.2 2.4 1 1 0 1 1 1 1 TLD Oxysterol_BP PF01237.13 ERZ97395.1 - 1.9e-63 214.0 0.0 2.3e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Oxysterol-binding protein Cyt-b5 PF00173.23 ERZ97396.1 - 9.1e-15 54.2 0.3 1.9e-14 53.2 0.2 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 ERZ97396.1 - 3e-14 53.1 18.7 3e-14 53.1 12.9 1.4 2 0 0 2 2 2 1 Fatty acid desaturase CHCH PF06747.8 ERZ97398.1 - 3.2e-06 26.8 6.8 5.1e-06 26.2 4.7 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ERZ97398.1 - 0.37 10.8 3.6 0.51 10.4 2.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 ERZ97398.1 - 0.53 10.1 8.3 3.4 7.5 5.8 2.1 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Sod_Cu PF00080.15 ERZ97399.1 - 1.7e-33 115.7 1.2 2.4e-33 115.2 0.8 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.21 ERZ97399.1 - 7.6e-14 51.6 0.5 1.3e-13 50.8 0.3 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF1939 PF09154.5 ERZ97399.1 - 0.019 14.8 0.1 0.064 13.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) UPF0220 PF05255.6 ERZ97400.1 - 6.3e-51 171.9 0.7 7.6e-51 171.6 0.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Myb_DNA-binding PF00249.26 ERZ97401.1 - 0.028 14.4 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ97401.1 - 0.045 13.8 0.2 0.11 12.6 0.2 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Hom_end_hint PF05203.11 ERZ97405.1 - 2.2e-31 109.2 0.0 2.2e-31 109.2 0.0 6.9 2 2 2 4 4 4 1 Hom_end-associated Hint GTP_EFTU PF00009.22 ERZ97405.1 - 3.2e-28 98.4 4.4 3.4e-27 95.0 0.0 3.6 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 ERZ97405.1 - 4.7e-18 65.0 0.9 1.4e-17 63.5 0.1 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 ERZ97405.1 - 7.6e-13 48.3 2.8 6.9e-10 38.8 0.1 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 Hint_2 PF13403.1 ERZ97405.1 - 0.0048 16.8 0.1 0.0094 15.8 0.0 1.4 1 0 0 1 1 1 1 Hint domain LIM_bind PF01803.11 ERZ97406.1 - 2.2e-39 134.9 5.7 1.8e-33 115.6 0.1 2.6 2 1 1 3 3 3 2 LIM-domain binding protein YqzE PF14038.1 ERZ97406.1 - 0.024 14.3 1.1 0.055 13.2 0.8 1.6 1 0 0 1 1 1 0 YqzE-like protein DERM PF14704.1 ERZ97407.1 - 0.064 13.2 0.8 0.078 12.9 0.5 1.1 1 0 0 1 1 1 0 Dermatopontin DUF1997 PF09366.5 ERZ97408.1 - 0.14 11.9 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) Herpes_ori_bp PF02399.10 ERZ97410.1 - 0.089 10.7 0.3 0.4 8.5 0.2 1.8 1 1 1 2 2 2 0 Origin of replication binding protein AGT PF11440.3 ERZ97411.1 - 0.051 12.4 0.2 0.068 12.0 0.1 1.2 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase DUF966 PF06136.8 ERZ97411.1 - 0.069 12.5 0.2 0.085 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CSTF_C PF14304.1 ERZ97412.1 - 0.017 14.3 0.0 0.069 12.4 0.0 2.0 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal T2SG PF08334.6 ERZ97412.1 - 0.075 12.7 0.1 0.11 12.2 0.1 1.3 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein G DUF4543 PF15076.1 ERZ97413.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4543) HMG_box PF00505.14 ERZ97416.1 - 4.9e-05 23.5 2.3 0.00012 22.3 1.6 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box TLD PF07534.11 ERZ97417.1 - 1.7e-15 57.2 0.4 1.4e-14 54.2 0.1 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ97417.1 - 3.7e-05 23.4 1.6 0.00086 19.1 0.1 3.0 1 1 2 3 3 3 2 BTB And C-terminal Kelch Pex16 PF08610.5 ERZ97418.1 - 1.2e-89 300.6 3.0 1.4e-89 300.4 2.1 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) EcsB PF05975.7 ERZ97418.1 - 0.01 14.3 0.2 0.01 14.3 0.1 2.0 2 0 0 2 2 2 1 Bacterial ABC transporter protein EcsB C2 PF00168.25 ERZ97419.1 - 5.2e-24 83.9 0.0 7.7e-24 83.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain B9-C2 PF07162.6 ERZ97419.1 - 0.095 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein Gal4_dimer PF03902.8 ERZ97420.1 - 0.036 13.9 0.8 0.052 13.4 0.6 1.2 1 0 0 1 1 1 0 Gal4-like dimerisation domain CRAL_TRIO_2 PF13716.1 ERZ97420.1 - 0.087 12.7 0.5 0.092 12.6 0.3 1.1 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Pkinase_Tyr PF07714.12 ERZ97423.1 - 3.1e-06 26.4 0.0 5.2e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97423.1 - 0.0077 15.4 0.1 0.019 14.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain XendoU PF09412.5 ERZ97423.1 - 0.035 13.1 3.2 0.038 13.0 2.2 1.0 1 0 0 1 1 1 0 Endoribonuclease XendoU Swi5 PF07061.6 ERZ97423.1 - 0.34 10.7 3.1 0.5 10.1 0.1 2.1 2 0 0 2 2 2 0 Swi5 FAR1 PF03101.10 ERZ97425.1 - 0.0036 17.7 1.4 0.0037 17.7 0.1 1.6 2 0 0 2 2 2 1 FAR1 DNA-binding domain RNB PF00773.14 ERZ97428.1 - 3.3e-100 335.5 0.0 3.3e-100 335.5 0.0 3.2 3 0 0 3 3 3 2 RNB domain Asp PF00026.18 ERZ97429.1 - 7.2e-110 367.1 0.0 8.8e-110 366.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 ERZ97429.1 - 8.7e-08 32.2 0.0 2.1e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 ERZ97429.1 - 6.7e-06 25.7 0.0 3.8e-05 23.2 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 ERZ97429.1 - 0.0052 17.2 0.4 0.21 12.1 0.0 2.9 3 1 0 3 3 3 1 Aspartyl protease PMSR PF01625.16 ERZ97430.1 - 6.9e-52 175.4 4.1 7.9e-52 175.2 2.8 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF530 PF04409.7 ERZ97430.1 - 0.037 12.1 0.7 0.047 11.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF530) DUF3993 PF13158.1 ERZ97430.1 - 0.083 12.6 0.2 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3993) Fe_dep_repr_C PF02742.10 ERZ97430.1 - 0.11 12.2 0.1 1.5 8.5 0.0 2.5 3 0 0 3 3 3 0 Iron dependent repressor, metal binding and dimerisation domain DUF3277 PF11681.3 ERZ97432.1 - 0.061 12.8 0.1 0.073 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) RNA_replicase_B PF03431.8 ERZ97433.1 - 0.023 12.9 0.5 0.032 12.4 0.3 1.2 1 0 0 1 1 1 0 RNA replicase, beta-chain DUF1542 PF07564.6 ERZ97433.1 - 0.069 13.1 0.3 0.069 13.1 0.2 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) USP8_dimer PF08969.6 ERZ97433.1 - 0.27 11.1 5.7 4.4 7.2 1.3 2.4 2 0 0 2 2 2 0 USP8 dimerisation domain Sel1 PF08238.7 ERZ97434.1 - 9.7e-73 239.0 29.6 3.1e-10 40.3 0.7 9.2 9 0 0 9 9 9 9 Sel1 repeat TPR_11 PF13414.1 ERZ97434.1 - 0.0011 18.5 29.3 1.1 8.8 0.3 6.0 4 1 2 6 6 6 4 TPR repeat MIT PF04212.13 ERZ97434.1 - 0.024 14.4 30.9 0.55 10.1 1.2 6.8 2 1 5 7 7 7 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ERZ97434.1 - 1.6 9.6 18.0 85 4.4 0.1 7.8 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat Pkinase PF00069.20 ERZ97436.1 - 8.5e-08 31.6 0.6 1.1e-07 31.2 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97436.1 - 1.2e-07 31.0 0.2 1.5e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase vATP-synt_AC39 PF01992.11 ERZ97436.1 - 0.035 13.2 0.6 0.05 12.7 0.4 1.1 1 0 0 1 1 1 0 ATP synthase (C/AC39) subunit MACPF PF01823.14 ERZ97437.1 - 0.0094 15.6 0.0 0.0098 15.6 0.0 1.0 1 0 0 1 1 1 1 MAC/Perforin domain Connexin50 PF03509.9 ERZ97437.1 - 0.082 13.2 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Gap junction alpha-8 protein (Cx50) Piwi PF02171.12 ERZ97438.1 - 1.1e-91 306.9 0.2 1.7e-91 306.3 0.1 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ97438.1 - 1.1e-18 66.7 1.5 1.3e-17 63.3 0.7 2.4 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ERZ97438.1 - 9.8e-13 47.2 0.0 2.1e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Pkinase PF00069.20 ERZ97439.1 - 5.9e-32 110.8 0.2 6.4e-32 110.7 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97439.1 - 1.6e-28 99.5 0.1 1.7e-28 99.4 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ97439.1 - 0.00023 20.2 0.0 0.00029 19.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ97439.1 - 0.015 14.2 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ERZ97439.1 - 0.03 13.6 0.1 0.037 13.3 0.1 1.1 1 0 0 1 1 1 0 RIO1 family DNA_pol3_a_NI PF14480.1 ERZ97439.1 - 0.053 13.1 0.4 0.96 9.1 0.0 2.2 1 1 1 2 2 2 0 DNA polymerase III polC-type N-terminus I DUF2299 PF10061.4 ERZ97439.1 - 0.085 12.2 0.3 0.75 9.2 0.0 2.3 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2299) Alph_Pro_TM PF09608.5 ERZ97439.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) PAP1 PF08601.5 ERZ97441.1 - 0.023 14.3 0.7 0.031 13.9 0.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 MSV199 PF10553.4 ERZ97441.1 - 0.34 10.7 4.9 0.41 10.5 3.4 1.3 1 1 0 1 1 1 0 MSV199 domain RNase_H PF00075.19 ERZ97442.1 - 4.5e-08 33.4 0.0 4.6e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 RNase H DUF2663 PF10864.3 ERZ97443.1 - 0.019 15.1 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Sec20 PF03908.8 ERZ97444.1 - 0.14 11.8 0.8 3.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Sec20 DUF3562 PF12085.3 ERZ97447.1 - 0.043 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3562) DUF3106 PF11304.3 ERZ97447.1 - 0.24 11.8 10.3 0.62 10.4 0.4 3.6 2 1 0 3 3 3 0 Protein of unknown function (DUF3106) Apolipoprotein PF01442.13 ERZ97447.1 - 0.52 9.7 12.5 0.3 10.5 5.1 2.6 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ndr PF03096.9 ERZ97447.1 - 0.95 7.8 6.9 0.71 8.2 1.5 2.3 2 0 0 2 2 2 0 Ndr family DUF3287 PF11690.3 ERZ97447.1 - 1 9.4 7.1 2.4 8.2 0.2 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3287) bZIP_1 PF00170.16 ERZ97447.1 - 4 7.4 32.2 0.042 13.8 2.8 4.3 4 1 0 4 4 4 0 bZIP transcription factor Med4 PF10018.4 ERZ97448.1 - 0.044 13.1 0.3 0.058 12.7 0.2 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF2481 PF10654.4 ERZ97450.1 - 0.092 12.4 3.0 1.7 8.3 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2481) DUF2034 PF10356.4 ERZ97451.1 - 3.3e-12 45.9 0.1 2.6e-10 39.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 ERZ97451.1 - 4.6e-12 45.7 0.0 8.5e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease DUF3858 PF12970.2 ERZ97452.1 - 0.064 13.0 0.2 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3858) DUF382 PF04037.8 ERZ97452.1 - 0.086 12.6 0.2 7.9 6.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF382) BCSC_C PF05420.6 ERZ97452.1 - 0.15 11.1 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Cellulose synthase operon protein C C-terminus (BCSC_C) PIG-Y PF15159.1 ERZ97453.1 - 0.1 12.8 2.2 0.27 11.4 1.5 1.8 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Connexin_CCC PF10582.4 ERZ97456.1 - 0.22 11.3 3.2 6.7 6.5 0.0 3.3 3 0 0 3 3 3 0 Gap junction channel protein cysteine-rich domain Ank_2 PF12796.2 ERZ97457.1 - 1e-09 38.5 0.0 0.00014 22.1 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ERZ97457.1 - 3.1e-09 37.0 2.7 0.012 16.1 0.0 5.1 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 ERZ97457.1 - 3.6e-08 33.3 0.6 0.041 14.1 0.1 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 ERZ97457.1 - 3.2e-05 23.5 2.5 0.036 13.8 0.0 4.9 7 0 0 7 7 7 2 Ankyrin repeat DUF3189 PF11385.3 ERZ97458.1 - 0.018 14.5 0.1 0.018 14.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) p450 PF00067.17 ERZ97461.1 - 6.3e-36 123.8 0.0 6.9e-36 123.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB PF00651.26 ERZ97462.1 - 2e-17 63.1 0.0 2.3e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain HTH_11 PF08279.7 ERZ97462.1 - 0.15 11.7 1.4 0.37 10.4 0.4 2.0 2 0 0 2 2 2 0 HTH domain TLD PF07534.11 ERZ97463.1 - 8.9e-17 61.3 0.3 8.9e-17 61.3 0.2 1.7 2 0 0 2 2 2 1 TLD BTB PF00651.26 ERZ97463.1 - 1e-11 44.7 0.1 2.2e-11 43.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ97463.1 - 3.6e-08 33.1 2.6 3.1e-06 26.9 0.3 3.5 2 1 1 3 3 3 2 BTB And C-terminal Kelch Sel1 PF08238.7 ERZ97464.1 - 5.3e-57 189.0 22.0 1.5e-12 47.6 0.3 6.2 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ97464.1 - 4.1e-06 26.9 15.5 0.35 11.4 0.7 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97464.1 - 7.2e-05 22.3 21.1 0.00069 19.2 2.4 4.0 2 1 2 4 4 4 3 TPR repeat TPR_16 PF13432.1 ERZ97464.1 - 0.00032 21.2 6.7 0.97 10.1 0.6 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_20 PF14561.1 ERZ97464.1 - 0.0044 17.1 4.0 0.81 9.8 0.2 4.0 2 2 2 4 4 4 1 Tetratricopeptide repeat DUF977 PF06163.6 ERZ97464.1 - 0.023 14.4 0.0 0.26 11.0 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF977) Peptidase_C39 PF03412.10 ERZ97464.1 - 0.046 13.5 0.1 0.084 12.6 0.1 1.3 1 0 0 1 1 1 0 Peptidase C39 family MIT PF04212.13 ERZ97464.1 - 0.46 10.3 17.9 2 8.3 0.1 4.8 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ97464.1 - 1.1 9.6 18.8 0.63 10.3 1.6 4.5 2 1 2 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 ERZ97464.1 - 2.7 8.9 11.8 7.2 7.6 0.1 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat Pkinase_Tyr PF07714.12 ERZ97465.1 - 2e-36 125.3 0.0 2.4e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97465.1 - 5e-36 124.1 0.0 6e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ97465.1 - 7.7e-05 21.8 0.1 0.00011 21.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97465.1 - 0.0017 18.1 0.1 0.0026 17.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ97465.1 - 0.014 14.6 0.5 0.023 13.9 0.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) DNase-RNase PF02577.9 ERZ97465.1 - 0.029 13.5 0.0 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 Bifunctional nuclease RIO1 PF01163.17 ERZ97465.1 - 0.038 13.3 0.2 0.054 12.8 0.2 1.3 1 0 0 1 1 1 0 RIO1 family SR-25 PF10500.4 ERZ97467.1 - 0.016 14.7 14.5 0.018 14.5 10.0 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Myc_target_1 PF15179.1 ERZ97467.1 - 0.75 9.3 7.8 0.93 9.0 5.4 1.0 1 0 0 1 1 1 0 Myc target protein 1 Transposase_21 PF02992.9 ERZ97475.1 - 6.5e-12 45.0 0.3 1e-06 28.0 0.0 2.0 1 1 1 2 2 2 2 Transposase family tnp2 DUF1258 PF06869.7 ERZ97475.1 - 0.12 11.3 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DDE_1 PF03184.14 ERZ97476.1 - 1.2e-11 44.1 0.1 1.3e-11 44.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 ERZ97477.1 - 0.0027 16.5 0.0 0.006 15.3 0.0 1.7 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain Ureidogly_hydro PF04115.7 ERZ97477.1 - 0.037 13.3 0.5 0.071 12.4 0.4 1.4 1 0 0 1 1 1 0 Ureidoglycolate hydrolase Phage_min_cap2 PF06152.6 ERZ97479.1 - 0.19 10.6 5.3 0.32 9.9 3.5 1.5 1 1 0 1 1 1 0 Phage minor capsid protein 2 Staphopain_pro PF14731.1 ERZ97480.1 - 0.079 12.7 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 Staphopain proregion E1_DerP2_DerF2 PF02221.10 ERZ97481.1 - 1.1e-06 28.9 0.1 1.3e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 ML domain Apolipoprotein PF01442.13 ERZ97483.1 - 0.00037 20.0 3.6 0.00052 19.5 2.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.5 ERZ97483.1 - 0.01 15.9 10.1 0.5 10.4 0.4 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Toxin_trans PF07952.7 ERZ97483.1 - 0.021 13.7 5.1 0.027 13.3 3.5 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Exonuc_VII_L PF02601.10 ERZ97483.1 - 0.05 12.8 9.0 0.057 12.6 6.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lectin_N PF03954.9 ERZ97483.1 - 0.058 12.8 2.3 0.091 12.1 0.7 1.9 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF2968 PF11180.3 ERZ97483.1 - 0.11 11.9 3.9 0.19 11.1 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) HlyD PF00529.15 ERZ97483.1 - 0.12 11.7 1.1 0.15 11.2 0.7 1.2 1 0 0 1 1 1 0 HlyD family secretion protein RapA_C PF12137.3 ERZ97483.1 - 0.23 10.2 9.3 1.1 8.0 1.4 2.0 1 1 1 2 2 2 0 RNA polymerase recycling family C-terminal DUF1043 PF06295.7 ERZ97483.1 - 1.3 8.6 9.4 1.8 8.2 6.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Fzo_mitofusin PF04799.8 ERZ97483.1 - 1.4 8.3 6.0 4.4 6.6 0.4 2.1 1 1 1 2 2 2 0 fzo-like conserved region DUF972 PF06156.8 ERZ97483.1 - 2.9 8.2 13.0 4.1 7.8 7.6 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Ax_dynein_light PF10211.4 ERZ97483.1 - 3.8 7.3 15.7 0.66 9.7 4.7 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain DUF4407 PF14362.1 ERZ97483.1 - 8.5 5.2 9.0 24 3.7 6.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SPATA24 PF15175.1 ERZ97484.1 - 0.026 14.2 1.7 0.05 13.2 1.2 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 Rootletin PF15035.1 ERZ97484.1 - 0.041 13.8 2.0 0.057 13.3 1.4 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion E2R135 PF11570.3 ERZ97484.1 - 0.095 12.7 0.6 0.21 11.6 0.4 1.6 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 Uso1_p115_C PF04871.8 ERZ97484.1 - 0.15 11.9 3.1 0.3 11.0 2.1 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Glyco_trans_4_2 PF13477.1 ERZ97485.1 - 0.0027 17.5 0.3 0.006 16.4 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like FNIP PF05725.7 ERZ97485.1 - 0.01 15.7 0.0 0.59 10.1 0.0 3.3 2 2 1 3 3 3 0 FNIP Repeat LRR_8 PF13855.1 ERZ97485.1 - 0.92 9.3 7.4 0.084 12.6 0.6 2.7 3 0 0 3 3 3 0 Leucine rich repeat WHG PF13305.1 ERZ97487.1 - 0.08 13.5 0.3 0.099 13.2 0.2 1.3 1 0 0 1 1 1 0 WHG domain Sulfate_transp PF00916.15 ERZ97488.1 - 3.3e-26 91.9 1.6 3.3e-26 91.9 1.1 1.5 2 0 0 2 2 2 1 Sulfate transporter family cNMP_binding PF00027.24 ERZ97488.1 - 1.4e-15 56.8 0.0 3.1e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.16 ERZ97488.1 - 5.4e-10 38.7 0.2 5e-09 35.5 0.0 2.2 1 1 1 2 2 2 1 STAS domain Pox_polyA_pol_N PF12630.2 ERZ97488.1 - 0.34 11.0 2.0 0.6 10.2 0.3 2.1 2 1 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain F-box-like_2 PF13013.1 ERZ97490.1 - 0.05 13.3 1.2 0.23 11.1 0.9 2.1 1 1 0 1 1 1 0 F-box-like domain LytTR PF04397.10 ERZ97490.1 - 0.083 12.9 1.9 0.18 11.9 0.5 2.1 1 1 1 2 2 2 0 LytTr DNA-binding domain Toxin_R_bind_C PF07951.7 ERZ97491.1 - 0.17 11.5 1.8 0.35 10.5 1.3 1.6 1 1 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding Lectin_C PF00059.16 ERZ97494.1 - 1.2 9.7 8.6 5.4 7.7 3.2 2.7 2 1 1 3 3 3 0 Lectin C-type domain Na_trans_assoc PF06512.8 ERZ97497.1 - 3.5 7.5 15.8 3.3 7.6 10.3 1.3 1 1 0 1 1 1 0 Sodium ion transport-associated BSD PF03909.12 ERZ97498.1 - 7e-17 60.9 0.6 7e-13 48.1 0.0 2.8 3 0 0 3 3 3 2 BSD domain RRM_6 PF14259.1 ERZ97499.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ERZ97499.1 - 0.099 12.2 0.2 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IncA PF04156.9 ERZ97499.1 - 0.88 9.1 10.2 1.7 8.1 7.0 1.5 1 0 0 1 1 1 0 IncA protein DnaJ PF00226.26 ERZ97500.1 - 2.3e-20 72.0 2.3 4.5e-20 71.1 1.6 1.5 1 0 0 1 1 1 1 DnaJ domain Gly-zipper_OmpA PF13436.1 ERZ97500.1 - 0.01 15.5 0.3 0.018 14.6 0.2 1.5 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain DUF456 PF04306.8 ERZ97500.1 - 0.03 14.3 0.3 0.043 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Gly-zipper_YMGG PF13441.1 ERZ97500.1 - 0.046 13.2 3.9 0.094 12.2 2.7 1.6 1 1 0 1 1 1 0 YMGG-like Gly-zipper Bacteriocin_IIc PF10439.4 ERZ97500.1 - 0.07 13.2 4.2 0.13 12.4 2.9 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_Omp PF13488.1 ERZ97500.1 - 2.9 7.5 8.2 0.32 10.6 2.6 1.7 2 0 0 2 2 2 0 Glycine zipper DUF1655 PF07868.6 ERZ97501.1 - 0.13 12.2 0.2 0.22 11.5 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1655) DZR PF12773.2 ERZ97502.1 - 0.0031 17.2 8.0 0.0031 17.2 5.6 6.9 3 1 4 7 7 7 4 Double zinc ribbon F-box-like PF12937.2 ERZ97503.1 - 7e-05 22.4 2.6 8.3e-05 22.2 0.2 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 ERZ97503.1 - 0.015 14.9 1.3 0.06 13.0 0.2 2.7 2 1 0 2 2 2 0 F-box domain LRR_6 PF13516.1 ERZ97503.1 - 1.5 9.1 6.5 7.8 6.9 0.5 4.5 3 0 0 3 3 3 0 Leucine Rich repeat Pkinase_Tyr PF07714.12 ERZ97504.1 - 2e-17 63.1 0.0 3.4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97504.1 - 3.8e-11 42.6 0.0 6.6e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain MAD PF05557.8 ERZ97504.1 - 0.00021 19.5 1.2 0.0003 19.0 0.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Pkinase PF00069.20 ERZ97506.1 - 6.3e-27 94.3 0.0 1.1e-26 93.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97506.1 - 5.1e-26 91.2 0.0 7.9e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ97506.1 - 0.26 10.9 0.3 0.4 10.3 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2373 PF10180.4 ERZ97507.1 - 0.06 12.8 0.6 0.06 12.8 0.4 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) DUF3978 PF13123.1 ERZ97508.1 - 0.03 13.7 0.2 0.041 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3978) DUF2442 PF10387.4 ERZ97508.1 - 0.044 13.7 0.6 0.19 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2442) Sel1 PF08238.7 ERZ97512.1 - 2.7e-36 123.2 15.9 1.8e-12 47.4 0.3 4.2 4 0 0 4 4 4 3 Sel1 repeat TPR_17 PF13431.1 ERZ97512.1 - 1.3e-06 28.1 7.8 1.6 9.1 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ97512.1 - 8e-06 25.9 6.1 1.4 9.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97512.1 - 5.5e-05 22.7 18.6 0.072 12.7 1.3 3.2 1 1 2 3 3 3 3 TPR repeat zf-GRF PF06839.7 ERZ97512.1 - 0.0002 21.2 6.9 2.5 8.0 0.0 3.2 3 0 0 3 3 3 3 GRF zinc finger NUMOD1 PF07453.8 ERZ97512.1 - 0.0044 16.8 0.0 7.1 6.6 0.0 3.3 3 0 0 3 3 3 1 NUMOD1 domain TPR_20 PF14561.1 ERZ97512.1 - 0.01 15.9 0.2 11 6.2 0.0 3.3 1 1 3 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97512.1 - 0.017 15.2 16.2 2.1 8.5 6.2 3.3 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DIL PF01843.14 ERZ97512.1 - 0.019 14.8 2.5 14 5.6 0.0 3.0 1 1 2 3 3 3 0 DIL domain Acylphosphatase PF00708.13 ERZ97512.1 - 0.02 14.9 0.1 21 5.2 0.0 3.0 1 1 2 3 3 3 0 Acylphosphatase DUF4160 PF13711.1 ERZ97512.1 - 0.031 14.1 0.8 3.4 7.5 0.0 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4160) TPR_16 PF13432.1 ERZ97512.1 - 0.038 14.6 1.0 39 5.0 0.1 3.5 1 1 3 4 4 4 0 Tetratricopeptide repeat TetR_C_5 PF08360.6 ERZ97512.1 - 0.048 13.6 1.0 0.087 12.7 0.7 1.5 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Rapamycin_bind PF08771.6 ERZ97512.1 - 0.061 13.4 5.5 7.3 6.7 0.2 3.1 3 0 0 3 3 3 0 Rapamycin binding domain DUF3674 PF12426.3 ERZ97512.1 - 0.071 12.5 0.3 7 6.1 0.2 2.9 3 0 0 3 3 3 0 RNA dependent RNA polymerase TPR_1 PF00515.23 ERZ97512.1 - 0.24 11.0 28.5 13 5.5 0.1 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF3012 PF11216.3 ERZ97512.1 - 0.53 10.0 3.9 41 3.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3012) TPR_2 PF07719.12 ERZ97512.1 - 3.2 7.9 24.5 22 5.2 0.1 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ERZ97515.1 - 1.4e-34 119.3 0.0 1.7e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97515.1 - 2.2e-26 92.6 0.0 3.4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MORN_2 PF07661.8 ERZ97515.1 - 0.23 11.5 2.5 1 9.5 0.1 3.1 2 1 0 2 2 2 0 MORN repeat variant Sel1 PF08238.7 ERZ97516.1 - 5.4e-15 55.4 6.0 3.2e-07 30.7 0.2 3.4 3 0 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ERZ97516.1 - 0.047 14.1 1.9 6.9 7.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Raffinose_syn PF05691.7 ERZ97516.1 - 0.071 10.6 0.0 0.084 10.3 0.0 1.0 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 DUF2391 PF09622.5 ERZ97518.1 - 0.2 10.7 0.0 0.2 10.7 0.0 2.7 2 1 1 3 3 3 0 Putative integral membrane protein (DUF2391) Pkinase_Tyr PF07714.12 ERZ97519.1 - 1.9e-36 125.4 0.0 2.8e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97519.1 - 2.1e-32 112.3 0.0 5.6e-32 110.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Sds3 PF08598.6 ERZ97519.1 - 0.064 12.7 3.8 0.11 12.0 2.7 1.3 1 0 0 1 1 1 0 Sds3-like DEAD PF00270.24 ERZ97521.1 - 3e-19 69.1 0.0 2.6e-18 66.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ97521.1 - 2e-10 40.3 0.0 3e-09 36.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ERZ97521.1 - 3.9e-06 26.8 0.0 6.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Peripla_BP_4 PF13407.1 ERZ97521.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein domain TLD PF07534.11 ERZ97522.1 - 1.7e-12 47.4 0.3 2.7e-12 46.8 0.2 1.3 1 0 0 1 1 1 1 TLD RNA_pol_Rpb1_3 PF04983.13 ERZ97522.1 - 0.037 13.7 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 RasGEF_N PF00618.15 ERZ97522.1 - 0.063 13.3 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 RasGEF N-terminal motif Dimer_Tnp_hAT PF05699.9 ERZ97523.1 - 2.9e-13 49.2 0.0 3.3e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ERZ97524.1 - 0.016 14.2 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Glyco_transf_64 PF09258.5 ERZ97525.1 - 0.0032 16.6 0.2 0.0041 16.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Sel1 PF08238.7 ERZ97526.1 - 2.4e-87 285.4 40.5 3.9e-14 52.7 1.0 7.7 8 0 0 8 8 8 7 Sel1 repeat TPR_6 PF13174.1 ERZ97526.1 - 2.2e-12 46.5 20.6 0.15 12.5 0.2 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat MIT PF04212.13 ERZ97526.1 - 2.1e-11 43.5 25.0 0.61 10.0 0.1 7.3 7 0 0 7 7 7 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ERZ97526.1 - 3.7e-07 29.7 6.3 24 4.7 0.0 7.0 7 0 0 7 7 7 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ERZ97526.1 - 0.00014 21.9 4.2 2.3 8.4 0.0 4.6 1 1 5 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97526.1 - 0.00063 19.7 25.1 3.7 7.9 0.1 8.3 7 2 0 7 7 7 2 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ERZ97526.1 - 0.0059 16.3 0.0 15 5.1 0.0 3.6 1 1 3 4 4 4 0 Caspase domain Helicase_RecD PF05127.9 ERZ97526.1 - 0.031 13.8 0.7 1.5 8.4 0.0 2.8 4 0 0 4 4 4 0 Helicase 23S_rRNA_IVP PF05635.6 ERZ97526.1 - 0.051 13.4 5.1 1.3 8.9 0.1 3.2 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein V-set PF07686.12 ERZ97526.1 - 0.11 12.4 7.5 1.8 8.4 0.2 4.2 1 1 3 4 4 4 0 Immunoglobulin V-set domain UPF0270 PF06794.7 ERZ97526.1 - 0.16 11.7 0.1 13 5.6 0.0 2.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0270) DUF3674 PF12426.3 ERZ97526.1 - 0.24 10.8 20.7 1.4 8.3 0.1 5.7 6 0 0 6 6 6 0 RNA dependent RNA polymerase HTH_16 PF12645.2 ERZ97526.1 - 0.36 10.7 6.9 16 5.5 0.1 4.2 5 0 0 5 5 5 0 Helix-turn-helix domain Apc3 PF12895.2 ERZ97526.1 - 0.44 10.7 30.7 1.6 8.9 3.6 5.1 2 2 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ERZ97526.1 - 0.53 10.3 47.3 8.8 6.5 0.3 10.8 12 0 0 12 12 12 0 Tetratricopeptide repeat DUF4041 PF13250.1 ERZ97526.1 - 1.3 8.5 14.8 17 5.0 0.0 6.2 7 1 1 8 8 8 0 Domain of unknown function (DUF4041) SAM_1 PF00536.25 ERZ97527.1 - 0.024 14.8 0.1 0.4 10.8 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) gag-asp_proteas PF13975.1 ERZ97528.1 - 0.00065 19.4 0.0 0.00097 18.9 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ERZ97528.1 - 0.0011 19.4 0.1 0.0038 17.7 0.0 1.9 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.15 ERZ97528.1 - 0.041 13.7 0.0 1 9.2 0.0 2.2 1 1 0 1 1 1 0 Retroviral aspartyl protease HSDR_N PF04313.9 ERZ97529.1 - 0.0086 15.8 0.0 0.0097 15.6 0.0 1.2 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) zf-C3HC4_3 PF13920.1 ERZ97532.1 - 2.6e-05 23.8 6.3 5.3e-05 22.8 4.4 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ97532.1 - 9e-05 22.1 7.7 0.00014 21.4 5.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ERZ97532.1 - 0.0001 22.0 5.0 0.0017 18.1 4.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 ERZ97532.1 - 0.0077 16.3 3.5 0.014 15.4 2.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ERZ97532.1 - 0.025 14.5 8.9 0.13 12.3 6.1 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ERZ97532.1 - 0.1 12.3 3.3 0.59 9.8 2.3 2.4 1 1 0 1 1 1 0 RING-type zinc-finger DUF4371 PF14291.1 ERZ97532.1 - 0.16 11.5 3.1 0.072 12.6 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4371) zf-C4_Topoisom PF01396.14 ERZ97532.1 - 0.16 11.4 2.1 0.44 10.0 0.1 2.3 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-C3HC4 PF00097.20 ERZ97532.1 - 0.17 11.5 8.8 0.59 9.8 6.1 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1272 PF06906.6 ERZ97532.1 - 0.22 11.4 4.5 0.42 10.4 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) C1_1 PF00130.17 ERZ97532.1 - 0.8 9.4 5.1 1.6 8.4 3.5 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_4 PF14570.1 ERZ97532.1 - 0.87 9.2 4.4 1.8 8.1 3.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 ERZ97535.1 - 0.048 13.2 2.2 0.11 12.0 1.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF640 PF04852.7 ERZ97536.1 - 0.4 10.8 0.1 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF640) 5_3_exonuc PF01367.15 ERZ97536.1 - 8.5 6.6 9.5 2.9 8.1 0.9 3.4 3 1 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Ion_trans PF00520.26 ERZ97537.1 - 4.5e-12 45.6 19.7 5.3e-12 45.4 13.7 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 ERZ97537.1 - 0.26 9.6 18.5 1.2 7.4 8.8 2.7 2 1 0 2 2 2 0 Polycystin cation channel PGG PF13962.1 ERZ97537.1 - 4.1 7.0 12.9 1.4 8.5 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function PHD PF00628.24 ERZ97538.1 - 7.9e-12 44.6 8.6 1.2e-11 44.0 5.9 1.2 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.17 ERZ97538.1 - 0.0005 19.7 6.8 0.0005 19.7 4.7 1.9 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.1 ERZ97538.1 - 0.0025 17.0 4.0 0.0025 17.0 2.8 2.1 2 0 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.1 ERZ97538.1 - 0.0025 17.4 3.4 0.0025 17.4 2.4 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 DUF1423 PF07227.6 ERZ97538.1 - 0.0049 15.5 3.4 0.0059 15.3 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1423) zf-HC5HC2H PF13771.1 ERZ97538.1 - 0.015 15.4 7.5 0.02 15.0 5.2 1.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain Cytochrom_CIII PF02085.11 ERZ97538.1 - 0.089 12.8 2.7 0.098 12.7 1.9 1.2 1 0 0 1 1 1 0 Class III cytochrome C family DUF4206 PF13901.1 ERZ97538.1 - 0.097 12.2 9.9 2.1 7.8 3.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) DUF2098 PF09871.4 ERZ97538.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) zf-PHD-like PF15446.1 ERZ97538.1 - 0.26 10.5 5.7 0.046 13.0 1.3 1.6 1 1 0 1 1 1 0 PHD/FYVE-zinc-finger like domain zinc-ribbons_6 PF07191.7 ERZ97538.1 - 1.4 8.7 8.6 16 5.3 6.0 2.0 1 1 0 1 1 1 0 zinc-ribbons Cytochrom_c3_2 PF14537.1 ERZ97538.1 - 1.8 8.9 8.6 0.3 11.4 3.1 1.7 1 1 0 2 2 2 0 Cytochrome c3 zf-CHY PF05495.7 ERZ97538.1 - 2 8.6 9.2 1.8 8.7 2.6 2.4 1 1 1 2 2 2 0 CHY zinc finger DNA_RNApol_7kD PF03604.8 ERZ97538.1 - 6.7 6.2 6.5 0.77 9.2 0.9 2.0 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Herpes_ori_bp PF02399.10 ERZ97542.1 - 2.3e-17 62.2 0.8 1.7e-15 56.0 0.1 2.1 2 0 0 2 2 2 2 Origin of replication binding protein LRR_6 PF13516.1 ERZ97543.1 - 1.7e-13 49.1 34.1 0.006 16.5 0.1 11.3 11 1 0 11 11 11 6 Leucine Rich repeat LRR_4 PF12799.2 ERZ97543.1 - 1.6e-09 37.1 26.7 0.0076 15.8 0.0 6.9 4 1 5 9 9 9 7 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ERZ97543.1 - 4.6e-06 25.9 16.9 6.3 7.4 0.0 9.4 11 0 0 11 11 11 1 Leucine rich repeat LRR_1 PF00560.28 ERZ97543.1 - 1e-05 24.8 23.6 3.1 8.1 0.0 10.3 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_8 PF13855.1 ERZ97543.1 - 0.0053 16.4 28.6 0.13 11.9 7.2 6.0 5 1 2 7 7 7 3 Leucine rich repeat Pkinase PF00069.20 ERZ97544.1 - 1.5e-27 96.3 0.5 1.2e-19 70.5 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97544.1 - 3.1e-24 85.4 0.0 6.8e-17 61.3 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase zf-CHCC PF10276.4 ERZ97544.1 - 0.026 14.3 2.1 0.2 11.5 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger domain APH PF01636.18 ERZ97544.1 - 0.45 10.2 1.2 0.68 9.6 0.8 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PDR_assoc PF08370.6 ERZ97548.1 - 0.072 12.5 0.3 0.14 11.6 0.2 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated PRANC PF09372.5 ERZ97548.1 - 0.5 10.3 4.0 0.46 10.4 0.6 2.1 2 0 0 2 2 2 0 PRANC domain TPR_12 PF13424.1 ERZ97549.1 - 2.9e-23 81.6 3.3 1.5e-06 28.0 0.0 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97549.1 - 3e-14 52.4 7.8 4.8e-06 26.1 0.1 4.4 4 0 0 4 4 4 3 TPR repeat TPR_2 PF07719.12 ERZ97549.1 - 3.7e-12 45.1 9.4 0.0087 15.9 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ97549.1 - 1.1e-10 40.5 4.7 0.13 11.8 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ97549.1 - 3.8e-08 32.5 3.5 3.5 7.6 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ97549.1 - 6.7e-07 28.6 10.2 0.19 11.5 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ97549.1 - 1e-06 28.4 5.2 0.083 12.8 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97549.1 - 6.6e-06 26.2 0.3 44 5.1 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97549.1 - 0.00025 21.6 1.0 0.85 10.3 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ97549.1 - 0.0007 19.8 3.0 45 4.8 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_L28e PF01778.12 ERZ97549.1 - 0.98 9.8 7.5 0.49 10.8 3.2 2.0 2 0 0 2 2 2 0 Ribosomal L28e protein family RNase_PH PF01138.16 ERZ97550.1 - 4.3e-34 117.6 0.1 9.1e-34 116.6 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ERZ97550.1 - 0.00046 20.0 0.2 0.00091 19.1 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 HMGL-like PF00682.14 ERZ97551.1 - 1.5e-58 198.2 0.0 1.9e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 HMGL-like E1-E2_ATPase PF00122.15 ERZ97552.1 - 8.3e-29 100.2 0.1 2.1e-28 98.9 0.1 1.7 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.3 ERZ97552.1 - 1.6e-28 98.9 0.6 4.1e-28 97.6 0.4 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter HAD PF12710.2 ERZ97552.1 - 2.1e-27 96.5 0.0 3.8e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ERZ97552.1 - 3.2e-14 53.8 0.0 5.3e-13 49.8 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ERZ97552.1 - 9.9e-05 22.2 0.0 0.00026 20.8 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 ERZ97552.1 - 0.0016 17.8 0.0 0.0041 16.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Ribosomal_L35Ae PF01247.13 ERZ97554.1 - 3.1e-33 113.3 1.9 3.5e-33 113.2 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae BTB PF00651.26 ERZ97555.1 - 8.3e-15 54.7 0.1 5.8e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ERZ97555.1 - 0.0015 18.3 0.1 0.063 13.1 0.0 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch SNase PF00565.12 ERZ97556.1 - 6.3e-57 190.4 0.1 1.6e-21 76.6 0.0 4.4 4 0 0 4 4 4 4 Staphylococcal nuclease homologue TUDOR PF00567.19 ERZ97556.1 - 2e-22 79.2 0.2 5.1e-22 77.9 0.1 1.8 2 0 0 2 2 2 1 Tudor domain Pkinase_Tyr PF07714.12 ERZ97557.1 - 5.1e-34 117.5 0.0 7.2e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97557.1 - 8.2e-33 113.6 1.3 1.1e-32 113.1 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ERZ97557.1 - 0.013 14.4 0.0 0.036 13.0 0.0 1.7 1 1 0 1 1 1 0 Kinase-like DUF4482 PF14818.1 ERZ97557.1 - 0.15 12.6 7.3 0.37 11.4 5.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) APH PF01636.18 ERZ97557.1 - 0.29 10.8 0.5 0.47 10.1 0.3 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ97558.1 - 7.3e-31 107.1 0.0 9.8e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97558.1 - 1.3e-28 99.9 0.0 1.9e-28 99.3 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ97558.1 - 0.062 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DTHCT PF08070.6 ERZ97559.1 - 0.22 12.1 2.1 0.33 11.6 1.4 1.3 1 1 0 1 1 1 0 DTHCT (NUC029) region Pkinase_Tyr PF07714.12 ERZ97561.1 - 1.7e-36 125.6 0.0 2.2e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97561.1 - 1.1e-35 123.0 0.1 1.8e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ97561.1 - 0.00087 19.0 0.1 0.0026 17.5 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ97561.1 - 0.0011 18.0 0.5 0.0018 17.3 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Trans_reg_C PF00486.23 ERZ97561.1 - 0.079 12.8 0.1 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal Occludin_ELL PF07303.8 ERZ97564.1 - 0.039 14.6 0.7 0.05 14.3 0.5 1.3 1 0 0 1 1 1 0 Occludin homology domain Sel1 PF08238.7 ERZ97565.1 - 2.8e-17 62.7 3.8 8.4e-08 32.6 0.0 3.1 3 0 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ERZ97565.1 - 0.0011 19.2 1.5 1.3 9.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ97565.1 - 0.0071 16.6 0.2 0.18 12.1 0.1 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97565.1 - 0.031 14.9 0.1 1.4 9.7 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ97565.1 - 0.47 10.1 4.0 1.5 8.5 0.1 2.8 2 1 0 2 2 2 0 TPR repeat Pkinase_Tyr PF07714.12 ERZ97566.1 - 9.6e-89 296.8 0.3 7.2e-47 159.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ97566.1 - 7.8e-81 271.0 8.3 1.5e-41 142.2 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Kinase-like PF14531.1 ERZ97566.1 - 5.2e-07 28.9 0.0 0.022 13.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ERZ97566.1 - 9.4e-05 21.5 1.1 0.01 14.8 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ97566.1 - 0.00077 18.8 2.7 0.033 13.5 0.2 2.8 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ97566.1 - 0.015 14.6 1.3 0.3 10.4 0.2 2.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.18 ERZ97566.1 - 0.35 10.5 2.2 1.9 8.1 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.26 ERZ97569.1 - 9e-19 67.5 0.4 1.9e-18 66.4 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ97569.1 - 2.9e-10 40.2 3.7 6.7e-10 39.0 2.6 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ97569.1 - 7.9e-07 28.8 2.0 6.1e-05 22.8 0.2 3.1 2 1 0 3 3 3 2 BTB And C-terminal Kelch Sel1 PF08238.7 ERZ97570.1 - 2.6e-57 189.9 9.7 4e-11 43.1 0.6 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ97570.1 - 0.01 16.2 6.8 1.7 9.2 0.0 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat OspD PF03207.8 ERZ97571.1 - 0.036 13.2 0.1 0.043 12.9 0.1 1.0 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) Recep_L_domain PF01030.19 ERZ97572.1 - 0.1 12.6 5.0 0.3 11.0 3.2 2.0 1 1 1 2 2 2 0 Receptor L domain DUF3211 PF11485.3 ERZ97573.1 - 0.011 15.7 0.2 0.022 14.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3211) Pkinase_Tyr PF07714.12 ERZ97573.1 - 0.03 13.4 0.3 0.17 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase Kunitz_BPTI PF00014.18 ERZ97574.1 - 0.0083 16.3 0.1 0.0083 16.3 0.1 1.7 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF908 PF06012.7 ERZ97575.1 - 0.042 13.1 2.4 0.053 12.8 1.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Zip PF02535.17 ERZ97575.1 - 0.3 10.0 1.2 0.35 9.8 0.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.12 ERZ97575.1 - 0.63 9.7 8.3 0.4 10.4 4.2 1.7 2 0 0 2 2 2 0 DDHD domain ATP11 PF06644.6 ERZ97575.1 - 0.83 9.0 10.7 0.47 9.8 6.1 1.6 2 0 0 2 2 2 0 ATP11 protein Sec62 PF03839.11 ERZ97575.1 - 3.8 6.8 10.9 40 3.5 6.9 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 AMIN PF11741.3 ERZ97576.1 - 0.1 12.5 0.6 9.2 6.3 0.0 2.1 1 1 1 2 2 2 0 AMIN domain Pex16 PF08610.5 ERZ97577.1 - 0.013 14.5 0.8 0.014 14.4 0.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF908 PF06012.7 ERZ97577.1 - 0.025 13.8 1.4 0.024 13.9 0.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DDHD PF02862.12 ERZ97577.1 - 0.065 13.0 3.4 0.08 12.7 2.4 1.1 1 0 0 1 1 1 0 DDHD domain ATP11 PF06644.6 ERZ97577.1 - 0.071 12.5 6.0 0.086 12.3 3.3 1.6 2 0 0 2 2 2 0 ATP11 protein TSGP1 PF07771.6 ERZ97577.1 - 1.6 8.5 8.0 2.1 8.2 5.5 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 DUF601 PF04642.7 ERZ97577.1 - 3.2 7.0 12.4 4.1 6.6 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 DUF2956 PF11169.3 ERZ97577.1 - 6.8 6.7 12.9 7.4 6.5 6.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Vfa1 PF08432.5 ERZ97578.1 - 0.0027 17.7 13.0 0.0029 17.6 9.0 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CRT10 PF08728.5 ERZ97578.1 - 0.038 11.9 1.9 0.04 11.9 1.3 1.2 1 0 0 1 1 1 0 CRT10 BLVR PF06375.6 ERZ97578.1 - 0.096 12.5 11.2 0.12 12.1 7.8 1.2 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) MCPVI PF02993.9 ERZ97578.1 - 0.16 12.1 1.7 0.19 11.8 1.2 1.1 1 0 0 1 1 1 0 Minor capsid protein VI DUF106 PF01956.11 ERZ97578.1 - 0.18 11.3 2.2 0.2 11.1 1.5 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 BTV_NS2 PF04514.7 ERZ97578.1 - 0.39 9.5 10.5 0.44 9.3 7.3 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Peptidase_S49_N PF08496.5 ERZ97578.1 - 0.39 10.5 8.2 0.44 10.3 5.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RP-C_C PF11800.3 ERZ97578.1 - 1.4 8.5 5.5 1.5 8.5 3.8 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region YlqD PF11068.3 ERZ97578.1 - 1.7 8.6 9.4 2 8.4 6.5 1.2 1 1 0 1 1 1 0 YlqD protein DUF4337 PF14235.1 ERZ97578.1 - 2.1 8.1 10.1 2.7 7.8 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF3987 PF13148.1 ERZ97578.1 - 2.9 6.3 8.4 3.6 6.0 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF3464 PF11947.3 ERZ97578.1 - 3.1 7.2 5.0 3.3 7.1 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Sec62 PF03839.11 ERZ97578.1 - 4.7 6.5 9.1 5.2 6.4 6.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DDHD PF02862.12 ERZ97578.1 - 6.4 6.5 8.0 7.2 6.3 5.5 1.1 1 0 0 1 1 1 0 DDHD domain RNase_H2-Ydr279 PF09468.5 ERZ97578.1 - 8.2 5.5 13.6 10 5.2 9.4 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Pex16 PF08610.5 ERZ97579.1 - 0.3 10.0 3.7 0.36 9.7 2.6 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) eIF_4EBP PF05456.6 ERZ97579.1 - 0.51 10.0 7.1 1.3 8.7 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) YebO PF13974.1 ERZ97579.1 - 2.1 8.2 8.1 2.5 7.9 1.8 2.2 2 0 0 2 2 2 0 YebO-like protein RNA_polI_A34 PF08208.6 ERZ97579.1 - 2.2 7.8 17.9 1.4 8.5 9.9 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Spc24 PF08286.6 ERZ97579.1 - 2.8 7.6 10.1 4.6 6.9 0.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 YqfQ PF14181.1 ERZ97579.1 - 4 7.4 11.5 14 5.7 3.9 2.1 2 0 0 2 2 2 0 YqfQ-like protein SURF1 PF02104.10 ERZ97580.1 - 8.5e-63 212.0 0.0 9.8e-63 211.8 0.0 1.0 1 0 0 1 1 1 1 SURF1 family bZIP_2 PF07716.10 ERZ97581.1 - 4.6e-09 35.9 11.6 4.6e-09 35.9 8.1 2.4 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.16 ERZ97581.1 - 0.00077 19.3 9.1 0.00077 19.3 6.3 2.3 2 0 0 2 2 2 1 bZIP transcription factor TFIIA PF03153.8 ERZ97581.1 - 0.0037 17.2 24.2 0.0063 16.4 16.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit ANAPC15 PF15243.1 ERZ97581.1 - 0.013 15.5 9.2 0.013 15.5 6.4 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 DUF1423 PF07227.6 ERZ97581.1 - 0.036 12.7 12.6 0.054 12.1 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) CDC27 PF09507.5 ERZ97581.1 - 0.11 11.6 34.1 0.16 11.1 23.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pneumo_att_G PF05539.6 ERZ97581.1 - 1.1 8.5 26.7 1.8 7.8 18.5 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Init_tRNA_PT PF04179.7 ERZ97582.1 - 4.7e-126 421.2 0.0 5.3e-126 421.1 0.0 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase DSPc PF00782.15 ERZ97582.1 - 1.4e-10 40.8 0.0 2.5e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.7 ERZ97582.1 - 0.0071 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.22 ERZ97582.1 - 0.041 13.2 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ERZ97582.1 - 0.047 13.9 0.0 0.076 13.2 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family SurA_N_3 PF13624.1 ERZ97583.1 - 0.038 13.9 0.5 0.045 13.7 0.3 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Imm22 PF15592.1 ERZ97583.1 - 0.042 14.1 0.7 0.1 12.9 0.3 1.8 1 1 0 1 1 1 0 Immunity protein 22 Act-Frag_cataly PF09192.5 ERZ97583.1 - 0.046 12.6 0.3 0.084 11.8 0.1 1.4 1 1 0 1 1 1 0 Actin-fragmin kinase, catalytic DUF4093 PF13331.1 ERZ97583.1 - 0.094 12.9 1.6 0.68 10.1 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4093) Pkinase PF00069.20 ERZ97584.1 - 0.00017 20.8 0.1 0.00018 20.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97584.1 - 0.035 13.1 0.0 0.038 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase NYN PF01936.13 ERZ97586.1 - 2e-10 41.1 0.0 3.1e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 NYN domain Pkinase_Tyr PF07714.12 ERZ97587.1 - 8.7e-39 133.1 1.7 1.6e-38 132.2 1.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97587.1 - 2.8e-37 128.2 5.3 4e-37 127.7 2.7 1.9 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ERZ97587.1 - 4.6e-09 36.6 10.3 6.8e-05 23.3 0.2 3.7 3 0 0 3 3 3 3 Sel1 repeat YrbL-PhoP_reg PF10707.4 ERZ97587.1 - 0.0027 17.0 0.4 0.0095 15.2 0.1 2.0 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ERZ97587.1 - 0.015 14.2 0.0 0.062 12.2 0.0 2.0 2 1 1 3 3 3 0 Kinase-like Kdo PF06293.9 ERZ97587.1 - 0.06 12.3 0.8 0.58 9.1 0.1 2.3 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ERZ97588.1 - 8.9e-31 106.9 3.5 1.1e-30 106.7 2.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97588.1 - 7.7e-30 103.8 0.1 9.9e-30 103.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ97588.1 - 0.0057 15.6 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ERZ97588.1 - 0.034 13.2 0.2 0.049 12.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ERZ97589.1 - 4.9e-05 23.8 0.3 6.3e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 Sel1 repeat Pkinase_Tyr PF07714.12 ERZ97590.1 - 2.9e-31 108.4 0.6 3.9e-31 108.0 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97590.1 - 5.2e-30 104.4 2.9 6.7e-30 104.1 2.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ97590.1 - 0.026 13.5 0.2 0.035 13.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ97590.1 - 0.061 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Mss4 PF04421.8 ERZ97591.1 - 3.8e-15 55.4 0.2 5.6e-15 54.9 0.1 1.3 1 0 0 1 1 1 1 Mss4 protein ATPase-cat_bd PF12156.3 ERZ97591.1 - 0.062 13.8 1.1 8.2 7.0 0.1 2.3 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase PIG-P PF08510.7 ERZ97592.1 - 1.6e-37 127.9 6.0 2.8e-37 127.1 4.2 1.4 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.7 ERZ97592.1 - 0.33 11.2 9.2 0.63 10.3 6.4 1.4 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Herpes_LAMP2 PF06126.6 ERZ97592.1 - 0.47 8.7 2.9 0.63 8.3 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus Latent membrane protein 2 FixQ PF05545.6 ERZ97592.1 - 1.8 8.2 10.7 0.2 11.3 1.1 2.6 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ zf-CCCH PF00642.19 ERZ97595.1 - 1.1e-13 50.5 30.8 6.6e-06 25.6 5.4 4.7 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ribosomal_S14 PF00253.16 ERZ97596.1 - 1.2e-17 62.9 6.0 1.3e-17 62.8 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.1 ERZ97596.1 - 0.071 12.8 0.3 0.091 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) DUF1451 PF07295.6 ERZ97596.1 - 0.083 12.6 0.1 0.083 12.6 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) RNA_POL_M_15KD PF02150.11 ERZ97596.1 - 0.26 10.9 2.1 11 5.8 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Ribosomal_L40e PF01020.12 ERZ97596.1 - 4.3 7.0 7.8 0.41 10.2 1.1 2.0 1 1 1 2 2 2 0 Ribosomal L40e family Nol1_Nop2_Fmu PF01189.12 ERZ97597.1 - 1.9e-27 96.3 0.0 5.3e-27 94.9 0.0 1.6 1 1 0 1 1 1 1 NOL1/NOP2/sun family PUA PF01472.15 ERZ97597.1 - 3.2e-06 26.7 0.0 7.3e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 PUA domain Methyltransf_18 PF12847.2 ERZ97597.1 - 0.00014 22.3 0.0 0.00032 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ97597.1 - 0.001 18.6 0.2 0.004 16.7 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ERZ97597.1 - 0.0018 18.3 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ERZ97597.1 - 0.028 14.4 0.0 0.057 13.3 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 ERZ97597.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ERZ97597.1 - 0.14 11.4 0.0 1.1 8.6 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase small domain AAA_35 PF14516.1 ERZ97598.1 - 1.4e-09 37.0 0.0 2.7e-09 36.1 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain Arch_ATPase PF01637.13 ERZ97598.1 - 0.00044 20.0 0.3 0.00091 18.9 0.0 1.7 2 0 0 2 2 2 1 Archaeal ATPase AAA_14 PF13173.1 ERZ97598.1 - 0.002 18.0 1.3 0.0035 17.2 0.2 2.0 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 ERZ97598.1 - 0.0065 16.6 0.1 0.041 14.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2584 PF10763.4 ERZ97598.1 - 0.015 15.1 0.1 0.21 11.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2584) AAA_16 PF13191.1 ERZ97598.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.4 ERZ97598.1 - 0.04 12.8 0.0 0.28 10.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 KaiC PF06745.8 ERZ97598.1 - 0.049 12.7 0.1 0.09 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.1 ERZ97598.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain KTI12 PF08433.5 ERZ97598.1 - 0.065 12.4 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_22 PF13401.1 ERZ97598.1 - 0.066 13.3 0.0 0.16 12.1 0.0 1.6 1 1 1 2 2 2 0 AAA domain RecA PF00154.16 ERZ97598.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Dimer_Tnp_hAT PF05699.9 ERZ97602.1 - 1e-09 37.8 0.1 2.1e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region STAT_int PF02865.12 ERZ97604.1 - 0.061 13.2 0.4 0.15 12.0 0.3 1.6 1 0 0 1 1 1 0 STAT protein, protein interaction domain F-box-like PF12937.2 ERZ97605.1 - 0.0014 18.3 0.5 0.003 17.2 0.3 1.5 1 0 0 1 1 1 1 F-box-like UDPGT PF00201.13 ERZ97606.1 - 2.1e-22 79.3 0.0 1.4e-21 76.6 0.0 2.0 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ERZ97606.1 - 1.1e-06 28.3 0.1 1.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ERZ97606.1 - 6.8e-06 25.5 0.0 0.00041 19.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_transf_28 PF03033.15 ERZ97606.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain BTB PF00651.26 ERZ97607.1 - 1.9e-15 56.7 0.9 3.9e-15 55.7 0.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ97607.1 - 3.6e-07 29.9 4.0 1.9e-06 27.6 0.3 3.0 3 0 0 3 3 3 1 BTB And C-terminal Kelch UDPGT PF00201.13 ERZ97608.1 - 1.2e-28 99.9 0.0 1e-27 96.9 0.0 2.1 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 ERZ97608.1 - 3.3e-10 39.6 0.0 2.3e-06 27.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 ERZ97608.1 - 6.2e-08 32.4 0.0 1.3e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.15 ERZ97608.1 - 0.0001 22.0 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Kelch_5 PF13854.1 ERZ97609.1 - 4.9e-12 45.5 0.1 3.4e-05 23.6 0.0 3.1 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.1 ERZ97609.1 - 8.8e-10 38.2 0.9 9.5e-05 22.0 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ97609.1 - 1.1e-07 31.7 3.3 0.0025 17.9 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 ERZ97609.1 - 2.4e-07 30.2 1.2 0.0039 16.9 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ERZ97609.1 - 3.1e-06 26.6 5.7 0.018 14.5 0.2 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ERZ97609.1 - 0.00043 20.3 2.0 0.23 11.6 0.0 2.8 3 1 0 3 3 3 2 Galactose oxidase, central domain Pkip-1 PF06878.6 ERZ97610.1 - 0.15 11.9 0.4 0.34 10.7 0.0 1.6 2 0 0 2 2 2 0 Pkip-1 protein Pkinase PF00069.20 ERZ97612.1 - 8.1e-72 241.4 0.0 1.1e-71 241.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97612.1 - 2.7e-31 108.6 0.0 3.8e-31 108.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ97612.1 - 0.011 15.4 0.2 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ERZ97612.1 - 0.042 12.6 0.1 0.067 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.1 ERZ97612.1 - 0.065 12.1 0.0 0.17 10.8 0.0 1.7 2 0 0 2 2 2 0 Kinase-like Thymidylat_synt PF00303.14 ERZ97613.1 - 1.6e-121 404.4 0.0 1.8e-121 404.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase DNA_pol_delta_4 PF04081.8 ERZ97614.1 - 1.1e-20 74.1 1.8 3.2e-20 72.6 1.2 1.8 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 PRP1_N PF06424.7 ERZ97614.1 - 3 8.1 7.8 6.5 7.0 5.4 1.6 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal Sec62 PF03839.11 ERZ97614.1 - 3.5 6.9 5.7 4.7 6.5 4.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PAP_assoc PF03828.14 ERZ97615.1 - 1.1e-15 57.2 0.1 3.7e-15 55.6 0.1 2.0 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ERZ97615.1 - 3.5e-11 43.2 0.2 2e-10 40.8 0.0 2.5 2 0 0 2 2 2 1 Nucleotidyltransferase domain DUF4269 PF14091.1 ERZ97615.1 - 0.0063 16.4 0.3 0.029 14.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4269) RdRP PF05183.7 ERZ97616.1 - 4.7e-64 217.1 0.3 7.4e-64 216.4 0.2 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase VirDNA-topo-I_N PF09266.5 ERZ97616.1 - 0.086 12.7 2.3 2.3 8.1 0.6 3.0 2 1 1 3 3 3 0 Viral DNA topoisomerase I, N-terminal Thymidylate_kin PF02223.12 ERZ97617.1 - 0.021 14.1 0.6 0.026 13.9 0.4 1.1 1 0 0 1 1 1 0 Thymidylate kinase Peptidase_C39_2 PF13529.1 ERZ97618.1 - 0.071 13.4 0.0 0.1 12.9 0.0 1.3 1 1 0 1 1 1 0 Peptidase_C39 like family F-box-like PF12937.2 ERZ97620.1 - 2.1e-06 27.3 1.5 3.6e-06 26.6 0.4 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ97620.1 - 3.3e-05 23.4 0.1 0.00011 21.7 0.1 1.9 1 0 0 1 1 1 1 F-box domain Myb_DNA-bind_4 PF13837.1 ERZ97621.1 - 1.5e-06 28.2 1.2 2.5e-06 27.5 0.8 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ERZ97621.1 - 2e-06 27.5 1.0 3.4e-06 26.8 0.7 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ97621.1 - 0.0025 17.8 0.2 0.0049 16.9 0.1 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ERZ97621.1 - 0.0083 16.7 0.2 0.012 16.2 0.2 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Methyltransf_21 PF05050.7 ERZ97623.1 - 0.16 11.8 2.4 0.69 9.8 0.9 2.3 2 1 1 3 3 3 0 Methyltransferase FkbM domain Med2 PF11214.3 ERZ97623.1 - 2.3 8.3 6.8 88 3.2 4.9 2.9 2 1 0 2 2 2 0 Mediator complex subunit 2 zf-C2H2 PF00096.21 ERZ97624.1 - 1.5e-12 47.0 6.8 9.6e-06 25.6 0.4 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ97624.1 - 1.2e-09 37.7 6.2 0.00034 20.7 0.7 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ERZ97624.1 - 4.8e-09 36.0 2.0 4.8e-09 36.0 1.4 2.1 2 0 0 2 2 2 1 Zinc-finger double domain Ogr_Delta PF04606.7 ERZ97624.1 - 0.012 15.2 0.1 0.26 10.9 0.0 2.1 1 1 1 2 2 2 0 Ogr/Delta-like zinc finger RPAP2_Rtr1 PF04181.8 ERZ97624.1 - 0.019 15.0 0.2 0.79 9.8 0.2 2.0 1 1 1 2 2 2 0 Rtr1/RPAP2 family zf-TRAF PF02176.13 ERZ97624.1 - 0.035 14.4 0.3 0.046 14.1 0.2 1.3 1 1 0 1 1 1 0 TRAF-type zinc finger CHORD PF04968.7 ERZ97624.1 - 0.11 12.7 0.8 1.9 8.8 0.3 2.0 1 1 1 2 2 2 0 CHORD zf-CGNR PF11706.3 ERZ97624.1 - 1.5 8.3 3.9 34 4.0 2.7 2.3 1 1 0 1 1 1 0 CGNR zinc finger zf-C2H2_6 PF13912.1 ERZ97624.1 - 7.4 6.6 6.5 1.4 8.9 0.8 2.4 2 1 0 2 2 2 0 C2H2-type zinc finger HSP70 PF00012.15 ERZ97627.1 - 4.7e-136 454.1 4.5 5.2e-136 454.0 3.1 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF1843 PF08898.5 ERZ97627.1 - 0.039 13.9 0.9 0.15 12.1 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) DUF357 PF04010.8 ERZ97627.1 - 0.058 13.0 0.7 0.41 10.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF357) DUF1464 PF07318.7 ERZ97627.1 - 0.082 11.7 0.1 0.25 10.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1464) Tup_N PF08581.5 ERZ97627.1 - 0.22 11.7 8.8 1.1e+02 3.0 6.1 3.0 1 1 0 1 1 1 0 Tup N-terminal DnaI_N PF07319.6 ERZ97627.1 - 1.3 9.3 5.7 0.35 11.1 0.8 2.4 2 1 0 2 2 2 0 Primosomal protein DnaI N-terminus AAA_13 PF13166.1 ERZ97627.1 - 1.6 7.0 18.0 0.066 11.6 0.5 2.1 2 0 0 2 2 2 0 AAA domain Myb_DNA-bind_6 PF13921.1 ERZ97629.1 - 0.019 15.0 0.3 0.18 11.9 0.0 2.7 3 1 0 3 3 3 0 Myb-like DNA-binding domain Corona_S2 PF01601.11 ERZ97629.1 - 0.049 11.7 0.8 0.055 11.5 0.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein AT_hook PF02178.14 ERZ97629.1 - 0.073 12.7 4.6 0.3 10.8 3.2 2.1 1 0 0 1 1 1 0 AT hook motif Taxilin PF09728.4 ERZ97629.1 - 4.7 6.2 8.7 6.9 5.6 5.9 1.4 1 1 0 1 1 1 0 Myosin-like coiled-coil protein UDPGT PF00201.13 ERZ97632.1 - 1.7e-25 89.5 0.0 3.1e-25 88.6 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ERZ97632.1 - 4e-08 33.1 0.0 5.2e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ERZ97632.1 - 5.6e-06 25.7 0.0 1.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 1 Ins_allergen_rp PF06757.8 ERZ97632.1 - 0.038 13.4 0.0 6 6.3 0.0 2.2 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification HSP70 PF00012.15 ERZ97633.1 - 7.9e-06 24.0 0.1 4.9e-05 21.4 0.0 2.3 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ97633.1 - 6.9e-05 21.5 0.0 0.14 10.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein MreB_Mbl PF06723.8 ERZ97634.1 - 4.3e-06 25.5 0.0 0.015 13.8 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ97634.1 - 4.8e-06 24.7 0.1 2.2e-05 22.5 0.0 2.0 2 1 0 2 2 2 1 Hsp70 protein HSP70 PF00012.15 ERZ97635.1 - 1.1e-09 36.8 0.0 4.1e-09 34.9 0.0 1.9 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ97635.1 - 9.7e-05 21.1 0.0 0.28 9.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DJ-1_PfpI PF01965.19 ERZ97635.1 - 0.057 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family F-box-like PF12937.2 ERZ97636.1 - 0.00027 20.5 3.0 0.00047 19.8 1.2 2.2 2 0 0 2 2 2 1 F-box-like Toxin_27 PF08099.6 ERZ97638.1 - 0.024 14.5 7.9 0.024 14.5 5.4 1.8 3 0 0 3 3 3 0 Scorpion calcine family F-box-like PF12937.2 ERZ97639.1 - 4.2e-07 29.5 2.4 1.3e-06 28.0 1.7 1.8 1 0 0 1 1 1 1 F-box-like Pkinase_Tyr PF07714.12 ERZ97640.1 - 1.3e-39 135.8 0.0 1.8e-39 135.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97640.1 - 3.8e-34 118.0 0.0 7.5e-34 117.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ERZ97640.1 - 0.037 12.9 0.0 0.073 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ERZ97640.1 - 0.23 11.1 0.8 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ97641.1 - 0.00021 20.4 0.0 0.00028 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97641.1 - 0.0034 16.5 0.0 0.0052 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain NAD_binding_1 PF00175.16 ERZ97644.1 - 1.6e-06 28.6 0.0 0.015 15.8 0.0 2.2 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain LRR_4 PF12799.2 ERZ97645.1 - 0.00075 19.0 14.7 0.17 11.5 1.3 4.6 2 2 0 2 2 2 2 Leucine Rich repeats (2 copies) Pkinase PF00069.20 ERZ97646.1 - 1.3e-18 67.0 0.5 1.3e-18 67.0 0.3 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97646.1 - 1.2e-15 57.2 0.4 3.5e-15 55.7 0.3 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ97646.1 - 0.0062 15.6 0.1 0.01 14.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97646.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family gag_pre-integrs PF13976.1 ERZ97648.1 - 0.12 12.0 0.7 0.23 11.1 0.5 1.6 1 1 0 1 1 1 0 GAG-pre-integrase domain Iso_dh PF00180.15 ERZ97653.1 - 2.1e-109 365.6 0.0 3.1e-109 365.1 0.0 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aconitase PF00330.15 ERZ97653.1 - 2.3e-53 181.3 0.0 3.6e-33 114.7 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 ERZ97653.1 - 8.4e-17 61.5 0.1 6.7e-16 58.5 0.1 2.2 1 1 0 1 1 1 1 Aconitase C-terminal domain Retrotrans_gag PF03732.12 ERZ97654.1 - 0.02 14.9 2.6 0.035 14.1 0.2 2.1 1 1 1 2 2 2 0 Retrotransposon gag protein DUF3800 PF12686.2 ERZ97654.1 - 0.92 9.1 6.9 1.2 8.7 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) BTB PF00651.26 ERZ97656.1 - 9.1e-35 119.0 2.7 3e-17 62.6 0.0 3.0 3 0 0 3 3 3 2 BTB/POZ domain BACK PF07707.10 ERZ97656.1 - 1.1e-14 54.1 6.2 1.3e-06 28.1 0.2 3.9 4 0 0 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ERZ97656.1 - 1.1e-08 35.2 8.5 1.1e-08 35.1 4.3 2.2 2 0 0 2 2 2 1 TLD DUF3342 PF11822.3 ERZ97656.1 - 1.9e-05 23.9 3.6 0.0082 15.3 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.12 ERZ97656.1 - 0.0013 17.9 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase BTB PF00651.26 ERZ97657.1 - 4.6e-19 68.4 0.2 8.2e-19 67.6 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97657.1 - 9.7e-08 32.0 1.5 2.3e-07 30.8 1.1 1.6 1 0 0 1 1 1 1 TLD BTB PF00651.26 ERZ97658.1 - 6.8e-16 58.2 0.1 8.9e-16 57.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3839 PF12943.2 ERZ97659.1 - 0.094 11.8 3.9 0.12 11.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3839) FliD_N PF02465.13 ERZ97660.1 - 0.93 9.8 7.2 6.9 7.1 1.2 2.8 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus F-box-like PF12937.2 ERZ97664.1 - 6.7e-05 22.5 2.7 0.00019 21.0 1.9 1.8 1 0 0 1 1 1 1 F-box-like Pox_A3L PF05288.6 ERZ97664.1 - 0.051 13.3 5.6 2.2 8.0 0.0 4.3 5 0 0 5 5 5 0 Poxvirus A3L Protein F-box-like PF12937.2 ERZ97665.1 - 0.00013 21.6 4.8 0.00016 21.3 1.4 2.4 2 0 0 2 2 2 1 F-box-like VHP PF02209.14 ERZ97665.1 - 0.066 12.9 0.5 0.22 11.2 0.3 1.9 1 0 0 1 1 1 0 Villin headpiece domain F-box-like PF12937.2 ERZ97666.1 - 2.5e-07 30.3 4.0 9.6e-07 28.4 2.8 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ97666.1 - 0.092 12.4 1.8 0.32 10.7 0.6 2.5 2 1 0 2 2 2 0 F-box domain Pkinase_Tyr PF07714.12 ERZ97667.1 - 1.5e-42 145.4 0.0 2.9e-42 144.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97667.1 - 6.3e-33 114.0 0.0 1.2e-32 113.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ97667.1 - 0.076 12.7 0.5 0.2 11.3 0.3 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family PDH PF02153.12 ERZ97667.1 - 0.09 11.6 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase F-box-like PF12937.2 ERZ97669.1 - 0.2 11.4 2.7 0.15 11.7 0.4 1.9 2 0 0 2 2 2 0 F-box-like Pkinase_Tyr PF07714.12 ERZ97670.1 - 3.4e-49 167.2 0.0 5e-49 166.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97670.1 - 6.6e-49 166.3 0.0 1.1e-48 165.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ97670.1 - 2.5e-23 81.9 0.7 3.3e-06 27.5 0.0 4.4 4 0 0 4 4 4 4 Sel1 repeat RIO1 PF01163.17 ERZ97670.1 - 0.0011 18.3 0.1 0.0021 17.4 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ97670.1 - 0.017 14.8 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ERZ97670.1 - 0.13 11.2 0.1 0.25 10.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Skp1_POZ PF03931.10 ERZ97671.1 - 0.00028 20.9 0.1 0.00059 19.8 0.1 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain MMR_HSR1 PF01926.18 ERZ97671.1 - 0.00097 19.0 0.0 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.12 ERZ97671.1 - 0.078 12.7 3.1 0.41 10.4 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF87 AAA_17 PF13207.1 ERZ97671.1 - 0.12 13.1 0.2 0.37 11.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain KSHV_K1 PF11049.3 ERZ97675.1 - 0.04 13.9 0.1 0.32 11.0 0.0 2.2 1 1 1 2 2 2 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus DUF489 PF04356.7 ERZ97675.1 - 0.083 12.4 0.1 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF489) ImmE5 PF11480.3 ERZ97675.1 - 4.2 7.2 5.0 1.6 8.6 0.0 2.6 3 0 0 3 3 3 0 Colicin-E5 Imm protein BTB PF00651.26 ERZ97676.1 - 7.3e-18 64.5 0.0 1.8e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ97676.1 - 8.5e-18 64.6 0.8 8.5e-18 64.6 0.5 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ97676.1 - 6e-07 29.2 4.9 1.7e-06 27.8 0.3 3.7 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF1366 PF07104.6 ERZ97676.1 - 0.034 13.7 2.7 0.43 10.2 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) Skp1 PF01466.14 ERZ97676.1 - 0.067 13.2 0.0 0.26 11.3 0.0 2.0 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Fer4 PF00037.22 ERZ97677.1 - 0.1 12.2 0.6 0.65 9.7 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain Striatin PF08232.7 ERZ97678.1 - 9.3e-05 22.7 0.6 0.00011 22.5 0.4 1.1 1 0 0 1 1 1 1 Striatin family bZIP_2 PF07716.10 ERZ97678.1 - 0.0013 18.5 1.3 0.0018 18.0 0.9 1.2 1 0 0 1 1 1 1 Basic region leucine zipper DivIC PF04977.10 ERZ97678.1 - 0.0031 16.9 1.7 0.0038 16.6 1.2 1.2 1 0 0 1 1 1 1 Septum formation initiator bZIP_1 PF00170.16 ERZ97678.1 - 0.0045 16.9 1.4 0.0058 16.5 0.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor DUF4398 PF14346.1 ERZ97678.1 - 0.012 15.5 1.9 0.013 15.5 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) GAS PF13851.1 ERZ97678.1 - 0.018 14.2 0.9 0.019 14.1 0.6 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.15 ERZ97678.1 - 0.024 13.7 2.5 0.024 13.7 1.7 1.0 1 0 0 1 1 1 0 Tropomyosin DUF972 PF06156.8 ERZ97678.1 - 0.055 13.8 0.7 0.057 13.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ERZ97678.1 - 0.058 13.7 1.0 0.074 13.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF2216 PF10226.4 ERZ97678.1 - 0.064 12.7 0.2 0.064 12.7 0.2 1.0 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) Packaging_FI PF14000.1 ERZ97678.1 - 0.064 13.4 0.7 0.076 13.2 0.5 1.2 1 0 0 1 1 1 0 DNA packaging protein FI TSC22 PF01166.13 ERZ97678.1 - 0.092 12.7 1.6 0.27 11.2 0.8 1.8 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF4337 PF14235.1 ERZ97678.1 - 0.1 12.4 1.4 0.098 12.4 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HlyD PF00529.15 ERZ97678.1 - 0.1 11.8 1.3 0.1 11.8 0.9 1.0 1 0 0 1 1 1 0 HlyD family secretion protein TMF_DNA_bd PF12329.3 ERZ97678.1 - 0.11 12.2 2.8 0.14 11.9 1.9 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.9 ERZ97678.1 - 0.16 11.6 0.8 0.18 11.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.3 ERZ97678.1 - 0.17 11.8 1.4 0.17 11.7 1.0 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6 PF04111.7 ERZ97678.1 - 0.23 10.4 1.6 0.23 10.4 1.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4140 PF13600.1 ERZ97678.1 - 0.27 11.7 1.9 0.33 11.4 1.3 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF3847 PF12958.2 ERZ97678.1 - 0.41 10.4 2.0 0.55 10.0 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) M PF02370.11 ERZ97678.1 - 0.87 10.1 4.1 11 6.7 0.7 2.5 1 1 1 2 2 2 0 M protein repeat UDG PF03167.14 ERZ97680.1 - 4.3e-26 91.2 0.5 6.5e-26 90.6 0.1 1.5 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily Gemini_AL1_M PF08283.6 ERZ97680.1 - 0.26 11.1 1.9 0.5 10.2 0.3 2.0 1 1 1 2 2 2 0 Geminivirus rep protein central domain IP_trans PF02121.13 ERZ97681.1 - 2.4e-99 331.6 2.2 2.7e-99 331.4 1.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DUF1242 PF06842.7 ERZ97682.1 - 1.1e-17 63.1 1.7 1.6e-17 62.6 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) LSR PF05624.9 ERZ97682.1 - 0.49 10.1 2.9 0.24 11.1 0.7 1.5 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) Dynactin PF12455.3 ERZ97683.1 - 1.5e-74 250.3 5.7 1.5e-74 250.3 3.9 2.8 3 0 0 3 3 3 1 Dynein associated protein LRR_4 PF12799.2 ERZ97683.1 - 0.012 15.2 0.0 0.063 12.9 0.0 2.3 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Fungal_trans_2 PF11951.3 ERZ97683.1 - 0.02 13.4 6.5 0.33 9.4 0.2 2.5 1 1 1 2 2 2 0 Fungal specific transcription factor domain TPR_MLP1_2 PF07926.7 ERZ97683.1 - 0.33 10.7 37.9 0.06 13.0 12.9 4.0 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein DUF572 PF04502.8 ERZ97683.1 - 0.37 9.9 25.5 1 8.4 17.6 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF572) NPV_P10 PF05531.7 ERZ97683.1 - 5 7.4 15.3 13 6.1 3.1 4.4 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein CAP_GLY PF01302.20 ERZ97684.1 - 4e-27 93.7 0.5 4.7e-27 93.4 0.4 1.1 1 0 0 1 1 1 1 CAP-Gly domain CCD PF07860.6 ERZ97684.1 - 0.0038 16.7 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 WisP family C-Terminal Region PAXNEB PF05625.6 ERZ97685.1 - 0.013 14.3 0.1 0.023 13.5 0.1 1.3 1 0 0 1 1 1 0 PAXNEB protein Pkinase_Tyr PF07714.12 ERZ97686.1 - 6.7e-08 31.9 0.5 7.8e-08 31.6 0.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97686.1 - 1.4e-05 24.3 0.1 1.8e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain BBIP10 PF14777.1 ERZ97686.1 - 0.029 13.7 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 Pkinase PF00069.20 ERZ97687.1 - 6.5e-46 156.5 13.8 4.3e-23 81.7 0.1 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97687.1 - 2.3e-38 131.7 8.5 6.4e-23 81.1 0.1 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.9 ERZ97687.1 - 8.3e-05 21.7 0.0 0.14 11.2 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ97687.1 - 0.0051 16.5 0.0 18 4.9 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ERZ97687.1 - 0.013 14.8 0.4 1.7 7.8 0.0 3.2 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Tup_N PF08581.5 ERZ97688.1 - 0.0033 17.5 0.4 0.0033 17.5 0.3 2.2 3 1 0 3 3 3 1 Tup N-terminal PolC_DP2 PF03833.8 ERZ97688.1 - 0.13 9.8 2.8 0.055 11.1 0.1 1.5 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 IncA PF04156.9 ERZ97688.1 - 0.28 10.7 12.3 0.026 14.1 2.0 2.2 2 0 0 2 2 2 0 IncA protein AAA_13 PF13166.1 ERZ97688.1 - 2.5 6.4 16.6 0.038 12.4 4.4 2.0 2 0 0 2 2 2 0 AAA domain DUF724 PF05266.9 ERZ97688.1 - 4 7.0 9.0 0.26 10.8 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Pkinase PF00069.20 ERZ97691.1 - 8.1e-11 41.5 0.6 8.1e-11 41.5 0.4 1.8 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ERZ97691.1 - 0.00014 21.2 0.1 0.00035 19.9 0.1 1.6 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ERZ97691.1 - 0.0015 17.8 0.3 0.0039 16.4 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ERZ97691.1 - 0.0019 17.2 0.4 0.0019 17.2 0.3 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PIP5K PF01504.13 ERZ97691.1 - 0.0044 16.1 1.1 0.011 14.8 0.1 2.1 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase YrbL-PhoP_reg PF10707.4 ERZ97691.1 - 0.01 15.1 0.1 0.024 13.9 0.1 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.12 ERZ97691.1 - 0.017 14.2 0.1 0.03 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase zf-UBR PF02207.15 ERZ97691.1 - 0.076 12.7 2.0 0.18 11.5 1.4 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Pkinase_Tyr PF07714.12 ERZ97694.1 - 0.0027 16.8 0.1 0.0045 16.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4413 PF14372.1 ERZ97695.1 - 0.0011 18.8 0.0 0.016 15.1 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) CM1 PF03026.10 ERZ97695.1 - 0.085 11.9 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Influenza C virus M1 protein Pyridoxal_deC PF00282.14 ERZ97696.1 - 2.3e-82 276.4 0.0 2.8e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 ERZ97696.1 - 2.7e-07 29.6 0.0 5.2e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ERZ97696.1 - 2.3e-06 26.9 0.0 3.3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Endonuc-FokI_C PF09254.6 ERZ97696.1 - 0.047 12.7 0.1 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal NAD_Gly3P_dh_C PF07479.9 ERZ97698.1 - 1.8e-12 47.1 0.0 1.9e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Sigma70_r1_1 PF03979.9 ERZ97698.1 - 0.11 12.4 0.1 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 DUF3279 PF11682.3 ERZ97700.1 - 0.0061 16.1 0.5 0.0061 16.1 0.4 3.3 3 1 0 3 3 3 1 Protein of unknown function (DUF3279) zinc-ribbons_6 PF07191.7 ERZ97700.1 - 0.017 14.9 0.6 0.017 14.9 0.4 3.5 3 0 0 3 3 3 0 zinc-ribbons FYVE PF01363.16 ERZ97700.1 - 0.026 14.3 9.6 2 8.3 0.2 3.4 3 0 0 3 3 3 0 FYVE zinc finger zf-H2C2_2 PF13465.1 ERZ97700.1 - 0.074 13.3 8.8 0.4 11.0 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double domain zf-UBR PF02207.15 ERZ97700.1 - 0.075 12.7 17.8 0.043 13.5 1.5 3.5 3 0 0 3 3 3 0 Putative zinc finger in N-recognin (UBR box) HypA PF01155.14 ERZ97700.1 - 2.3 7.9 12.1 4.1 7.1 0.3 3.5 3 1 0 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-C2HC_2 PF13913.1 ERZ97700.1 - 2.7 7.7 11.9 0.78 9.4 0.2 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Desulfoferrod_N PF06397.7 ERZ97700.1 - 6.1 6.3 9.2 1.2 8.5 1.7 2.6 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain RNase_H PF00075.19 ERZ97701.1 - 1e-18 67.9 0.3 4.3e-18 65.9 0.2 2.2 1 0 0 1 1 1 1 RNase H Thia_YuaJ PF09515.5 ERZ97701.1 - 0.31 10.7 0.4 0.81 9.4 0.1 1.8 2 0 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) BTB PF00651.26 ERZ97702.1 - 6.5e-16 58.3 0.2 9.3e-16 57.7 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ97702.1 - 0.0063 16.3 1.0 2 8.2 0.0 3.1 2 1 1 3 3 3 2 BTB And C-terminal Kelch BTB_2 PF02214.17 ERZ97702.1 - 0.018 15.2 1.0 0.44 10.7 0.1 2.1 1 1 1 2 2 2 0 BTB/POZ domain TLD PF07534.11 ERZ97703.1 - 3.4e-13 49.7 0.5 6.8e-12 45.5 0.3 2.5 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ97703.1 - 5.9e-05 22.8 1.4 0.00022 20.9 0.1 2.4 2 1 1 3 3 3 1 BTB And C-terminal Kelch Phosphorylase PF00343.15 ERZ97704.1 - 1.4e-155 519.0 2.1 1.6e-155 518.9 1.5 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DEAD PF00270.24 ERZ97705.1 - 1.7e-40 138.2 0.0 3.4e-40 137.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ97705.1 - 8.7e-25 86.3 0.0 2.1e-24 85.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain GUCT PF08152.7 ERZ97705.1 - 1.9e-14 53.3 0.0 5.1e-14 52.0 0.0 1.8 1 0 0 1 1 1 1 GUCT (NUC152) domain Dimer_Tnp_hAT PF05699.9 ERZ97707.1 - 4.4e-22 77.5 0.6 4.8e-22 77.3 0.4 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ERZ97708.1 - 4.4e-11 42.6 0.0 7.5e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) SnoaL PF07366.7 ERZ97708.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase zf-RING_2 PF13639.1 ERZ97709.1 - 2.3e-14 52.9 7.7 3.5e-14 52.3 5.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ERZ97709.1 - 6.1e-09 35.8 2.2 9.9e-09 35.1 1.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ERZ97709.1 - 1.8e-08 34.2 8.5 2.8e-08 33.6 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ERZ97709.1 - 2.6e-07 30.1 8.2 4.1e-07 29.5 5.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ97709.1 - 3.9e-07 29.6 7.2 5.7e-07 29.1 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ERZ97709.1 - 4.4e-06 26.2 6.1 6.7e-06 25.6 4.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ERZ97709.1 - 5.5e-05 22.9 1.9 9.6e-05 22.1 1.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ERZ97709.1 - 0.0095 15.6 2.0 0.0095 15.6 1.4 1.9 1 1 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.2 ERZ97709.1 - 0.019 14.9 9.5 0.032 14.2 6.6 1.4 1 0 0 1 1 1 0 RING-variant domain zf-Nse PF11789.3 ERZ97709.1 - 0.035 13.6 3.0 0.1 12.1 2.2 1.7 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.6 ERZ97709.1 - 0.091 12.7 8.9 0.16 11.9 6.1 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.1 ERZ97709.1 - 0.15 11.6 7.3 0.39 10.3 5.1 1.6 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 ERZ97709.1 - 0.77 9.6 5.0 1.6 8.6 3.4 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.9 ERZ97709.1 - 2.3 7.7 5.4 5.8 6.4 0.5 2.3 1 1 1 2 2 2 0 P-11 zinc finger FANCL_C PF11793.3 ERZ97709.1 - 3.2 7.7 8.6 9.8 6.2 5.9 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Pkinase_Tyr PF07714.12 ERZ97710.1 - 6e-05 22.2 0.2 0.0001 21.5 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase ABC_membrane_2 PF06472.10 ERZ97710.1 - 0.012 14.7 0.2 0.014 14.4 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Pkinase PF00069.20 ERZ97710.1 - 0.052 12.6 0.0 0.085 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain MCM_N PF14551.1 ERZ97711.1 - 1.4e-11 44.9 2.9 1.6e-11 44.7 2.0 1.1 1 0 0 1 1 1 1 MCM N-terminal domain ABC1 PF03109.11 ERZ97713.1 - 1.2e-20 73.6 0.1 4.9e-20 71.6 0.0 2.1 2 1 0 2 2 2 1 ABC1 family Pkinase PF00069.20 ERZ97713.1 - 0.07 12.2 1.7 7.8 5.5 0.2 3.2 3 0 0 3 3 3 0 Protein kinase domain Myb_DNA-bind_4 PF13837.1 ERZ97714.1 - 6.3e-10 39.0 0.2 1.3e-09 38.0 0.1 1.6 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ERZ97714.1 - 0.0063 16.3 0.3 0.016 15.1 0.2 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ97714.1 - 0.021 14.9 1.4 0.16 12.0 1.0 2.5 1 1 0 1 1 1 0 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 ERZ97714.1 - 0.023 14.8 0.0 0.054 13.6 0.0 1.8 1 1 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like rve_3 PF13683.1 ERZ97714.1 - 0.037 13.5 0.1 0.094 12.2 0.1 1.6 1 0 0 1 1 1 0 Integrase core domain Myb_DNA-bind_3 PF12776.2 ERZ97714.1 - 0.048 14.2 0.4 0.074 13.6 0.3 1.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Corona_nucleoca PF00937.13 ERZ97714.1 - 0.19 10.6 3.6 0.23 10.3 2.5 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein BTB PF00651.26 ERZ97715.1 - 2.7e-07 30.5 0.2 1.3e-06 28.3 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain BTB PF00651.26 ERZ97716.1 - 9.5e-19 67.4 0.2 2.2e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain PRESAN PF09687.5 ERZ97716.1 - 0.095 12.7 0.2 0.095 12.7 0.1 1.8 2 0 0 2 2 2 0 Plasmodium RESA N-terminal DUF3447 PF11929.3 ERZ97718.1 - 0.042 13.6 0.3 0.076 12.8 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3447) DUF4116 PF13475.1 ERZ97718.1 - 0.047 13.1 0.0 0.14 11.6 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4116) DUF161 PF02588.10 ERZ97719.1 - 1.4 9.2 10.5 0.44 10.8 0.3 3.4 2 2 0 2 2 2 0 Uncharacterized BCR, YitT family COG1284 HMG_box PF00505.14 ERZ97721.1 - 2.5e-09 37.2 0.8 3.8e-09 36.6 0.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ97721.1 - 0.00068 19.9 1.2 0.0011 19.3 0.8 1.2 1 0 0 1 1 1 1 HMG-box domain Snf7 PF03357.16 ERZ97722.1 - 7.6e-50 168.6 14.1 7.6e-50 168.6 9.8 1.7 2 0 0 2 2 2 1 Snf7 FMN_bind PF04205.9 ERZ97722.1 - 0.021 14.9 0.8 0.077 13.1 0.1 2.2 2 1 0 2 2 2 0 FMN-binding domain DUF1640 PF07798.6 ERZ97722.1 - 0.022 14.8 6.9 0.34 10.9 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF2586 PF10758.4 ERZ97722.1 - 0.038 13.0 2.6 0.046 12.7 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) CCP_MauG PF03150.9 ERZ97722.1 - 0.44 10.8 2.2 0.85 9.8 1.5 1.6 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase TraF_2 PF13729.1 ERZ97722.1 - 0.51 9.0 8.2 0.11 11.3 1.6 2.2 1 1 0 2 2 2 0 F plasmid transfer operon, TraF, protein Prefoldin_2 PF01920.15 ERZ97722.1 - 0.6 9.8 12.3 0.89 9.3 2.0 3.5 3 1 0 3 3 3 0 Prefoldin subunit Atg14 PF10186.4 ERZ97722.1 - 1.4 7.8 10.4 2.9 6.7 7.2 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Viral_P18 PF04521.8 ERZ97722.1 - 4.5 6.7 10.1 0.52 9.7 2.0 2.7 2 1 0 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein UAA PF08449.6 ERZ97723.1 - 0.00011 21.2 17.7 0.0002 20.3 12.3 1.3 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.10 ERZ97723.1 - 0.00019 20.6 0.5 0.00019 20.6 0.4 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 ERZ97723.1 - 0.00043 20.3 6.2 0.00043 20.3 4.3 4.0 3 2 0 3 3 3 2 EamA-like transporter family TPT PF03151.11 ERZ97723.1 - 0.0098 15.5 8.8 0.0098 15.5 6.1 2.9 2 1 1 3 3 3 1 Triose-phosphate Transporter family B12D PF06522.6 ERZ97724.1 - 7.1e-16 57.6 0.0 8.4e-16 57.4 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit CLTH PF10607.4 ERZ97726.1 - 0.083 12.5 0.3 0.13 11.9 0.2 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Pkinase PF00069.20 ERZ97727.1 - 0.00066 18.9 0.0 0.00096 18.3 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97727.1 - 0.0022 17.0 0.0 0.0023 17.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Phage_min_cap2 PF06152.6 ERZ97727.1 - 0.015 14.2 0.1 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 Phage minor capsid protein 2 Baculo_gp41 PF04700.7 ERZ97727.1 - 0.06 12.7 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region DUF999 PF06198.6 ERZ97727.1 - 0.061 13.1 0.4 0.076 12.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF999) Pept_tRNA_hydro PF01195.14 ERZ97729.1 - 1.6e-32 112.4 0.1 1.8e-32 112.2 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase NUMOD1 PF07453.8 ERZ97729.1 - 0.012 15.4 0.7 0.03 14.1 0.2 1.9 2 0 0 2 2 2 0 NUMOD1 domain RecQ5 PF06959.6 ERZ97730.1 - 0.29 10.7 1.5 0.87 9.1 0.0 1.9 2 0 0 2 2 2 0 RecQ helicase protein-like 5 (RecQ5) MutS_V PF00488.16 ERZ97731.1 - 6.4e-96 320.2 0.0 1.2e-95 319.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ERZ97731.1 - 9.3e-39 133.3 3.2 9.3e-39 133.3 2.2 1.8 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.12 ERZ97731.1 - 3e-20 72.6 0.4 1.2e-19 70.7 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 ERZ97731.1 - 1e-18 67.2 1.2 1e-18 67.2 0.9 2.5 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.15 ERZ97731.1 - 5.7e-11 42.4 0.0 1.4e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 MutS domain I Transposase_22 PF02994.9 ERZ97731.1 - 0.015 13.8 5.9 0.03 12.8 4.1 1.5 1 0 0 1 1 1 0 L1 transposable element Med9 PF07544.8 ERZ97731.1 - 0.18 11.5 3.4 4.1 7.2 0.2 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Histone PF00125.19 ERZ97732.1 - 8.6e-23 80.2 0.0 1.2e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ERZ97732.1 - 0.0033 17.4 0.0 0.0048 16.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TRAPP PF04051.11 ERZ97733.1 - 2.4e-46 157.0 0.0 2.9e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component ERO1 PF04137.10 ERZ97734.1 - 4.9e-131 436.9 5.0 4.9e-131 436.9 3.4 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CBM_10 PF02013.11 ERZ97734.1 - 3.4 7.9 6.2 6.6 7.0 0.6 3.4 3 0 0 3 3 3 0 Cellulose or protein binding domain SANTA PF09133.5 ERZ97735.1 - 7.4e-11 41.8 0.0 1.8e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 SANTA (SANT Associated) DUSP PF06337.7 ERZ97735.1 - 6.8 7.1 8.2 2 8.8 2.3 2.4 2 0 0 2 2 2 0 DUSP domain SnoaL_2 PF12680.2 ERZ97736.1 - 0.0046 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 ERZ97736.1 - 0.025 14.7 0.0 5.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) DUF2392 PF10288.4 ERZ97737.1 - 2.4e-25 88.9 0.1 7.3e-25 87.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2392) ATP_bind_3 PF01171.15 ERZ97737.1 - 0.00022 20.8 0.0 0.00059 19.3 0.0 1.7 1 0 0 1 1 1 1 PP-loop family zf-C3HC4_3 PF13920.1 ERZ97737.1 - 3 7.6 13.0 0.99 9.1 1.4 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.11 ERZ97738.1 - 0.0015 17.3 4.5 0.0016 17.1 3.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Pkinase_Tyr PF07714.12 ERZ97740.1 - 1.2e-05 24.5 0.0 2.8e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97740.1 - 0.016 14.3 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain FAR1 PF03101.10 ERZ97741.1 - 7.1e-05 23.2 0.2 0.00013 22.3 0.1 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain DUF3289 PF11692.3 ERZ97745.1 - 0.091 12.0 0.0 0.091 12.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) Abhydrolase_3 PF07859.8 ERZ97746.1 - 0.0059 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 ERZ97747.1 - 8.2e-40 136.6 0.1 3.4e-37 128.0 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ERZ97747.1 - 6.3e-08 31.6 0.0 1.1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ERZ97747.1 - 5e-06 26.3 0.0 6.6e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family P53_tetramer PF07710.6 ERZ97748.1 - 0.018 14.1 0.0 2.8 7.1 0.0 2.1 2 0 0 2 2 2 0 P53 tetramerisation motif Pkinase_Tyr PF07714.12 ERZ97749.1 - 1.4e-32 112.7 0.0 1.6e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97749.1 - 1.6e-32 112.6 0.2 1.8e-32 112.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ97749.1 - 0.02 14.6 0.1 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_A31 PF05771.6 ERZ97749.1 - 0.083 12.7 0.4 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 Poxvirus A31 protein Methyltransf_23 PF13489.1 ERZ97750.1 - 6.8e-14 51.9 0.0 1e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ97750.1 - 1.9e-13 50.7 0.0 3.7e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ97750.1 - 2.5e-13 49.9 0.0 1e-12 47.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ97750.1 - 3.3e-11 42.7 0.0 3.1e-10 39.5 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ERZ97750.1 - 1.3e-10 41.5 0.0 2.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ97750.1 - 1.8e-07 31.7 0.0 1.1e-06 29.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ERZ97750.1 - 3.3e-06 27.1 0.0 6.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ97750.1 - 7.8e-06 25.0 0.0 0.00013 21.1 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.7 ERZ97750.1 - 8.3e-06 26.2 0.0 2.7e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 ERZ97750.1 - 5e-05 23.0 0.0 0.00012 21.8 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase CMAS PF02353.15 ERZ97750.1 - 0.0008 18.5 0.1 0.0037 16.3 0.1 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.11 ERZ97750.1 - 0.0062 14.9 0.0 0.042 12.1 0.0 1.9 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 ERZ97750.1 - 0.018 14.4 0.0 0.1 11.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.14 ERZ97750.1 - 0.036 14.0 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PriCT_1 PF08708.6 ERZ97750.1 - 0.07 12.9 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 Primase C terminal 1 (PriCT-1) Pkinase_Tyr PF07714.12 ERZ97751.1 - 6e-30 104.1 0.0 6.6e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97751.1 - 1.9e-27 96.0 0.0 2.1e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ERZ97751.1 - 0.00056 18.9 0.0 0.0006 18.8 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ97751.1 - 0.00092 19.0 0.2 0.0026 17.5 0.2 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ERZ97751.1 - 0.0021 17.2 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ERZ97751.1 - 0.004 16.2 0.0 0.0048 15.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ97751.1 - 0.0085 15.4 0.1 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Aldose_epim PF01263.15 ERZ97753.1 - 1.1e-42 146.2 0.1 1.2e-42 146.0 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Fanconi_C PF02106.10 ERZ97753.1 - 0.087 11.2 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia group C protein Toprim_3 PF13362.1 ERZ97753.1 - 0.099 12.8 0.3 3.7 7.8 0.1 2.4 2 1 0 2 2 2 0 Toprim domain ubiquitin PF00240.18 ERZ97754.1 - 1.4e-25 88.4 0.5 1.8e-25 88.1 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ97754.1 - 1e-12 47.5 0.8 1.3e-12 47.1 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ97754.1 - 6.4e-08 32.7 0.1 1.4e-07 31.6 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ERZ97754.1 - 0.014 15.2 0.2 0.042 13.7 0.2 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like USP7_C2 PF14533.1 ERZ97754.1 - 0.054 12.9 0.1 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal bZIP_1 PF00170.16 ERZ97756.1 - 3.8e-09 36.3 5.6 6.1e-09 35.7 3.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ERZ97756.1 - 2.6e-08 33.5 6.8 4.4e-08 32.8 4.7 1.4 1 0 0 1 1 1 1 Basic region leucine zipper OprD PF03573.8 ERZ97757.1 - 0.018 13.8 2.1 0.032 13.0 1.4 1.3 1 0 0 1 1 1 0 outer membrane porin, OprD family K_oxygenase PF13434.1 ERZ97757.1 - 0.063 12.1 0.8 0.12 11.2 0.5 1.5 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Peptidase_S66 PF02016.10 ERZ97758.1 - 0.071 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 LD-carboxypeptidase DNA_ligase_A_C PF04679.10 ERZ97759.1 - 0.089 13.2 0.0 3 8.2 0.0 2.5 2 0 0 2 2 2 0 ATP dependent DNA ligase C terminal region DUF148 PF02520.12 ERZ97761.1 - 0.083 12.6 0.4 0.11 12.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 Gag_MA PF01140.14 ERZ97761.1 - 0.19 11.5 1.3 3 7.7 0.9 2.2 1 1 0 1 1 1 0 Matrix protein (MA), p15 CAP_assoc_N PF14504.1 ERZ97764.1 - 0.091 12.4 0.4 0.11 12.1 0.2 1.1 1 0 0 1 1 1 0 CAP-associated N-terminal KLRAQ PF10205.4 ERZ97766.1 - 0.0028 17.6 1.0 0.0028 17.6 0.7 3.0 3 1 0 3 3 3 1 Predicted coiled-coil domain-containing protein bZIP_1 PF00170.16 ERZ97766.1 - 0.2 11.6 14.5 0.67 9.9 0.6 4.0 2 1 0 3 3 3 0 bZIP transcription factor DUF3373 PF11853.3 ERZ97766.1 - 1.2 7.5 3.8 1.4 7.3 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3373) TSC22 PF01166.13 ERZ97766.1 - 2.1 8.3 11.6 2.1 8.3 1.8 3.2 1 1 1 2 2 2 0 TSC-22/dip/bun family Shugoshin_N PF07558.6 ERZ97766.1 - 3.3 7.4 12.7 0.16 11.7 1.6 3.7 2 1 2 4 4 4 0 Shugoshin N-terminal coiled-coil region TMF_TATA_bd PF12325.3 ERZ97766.1 - 4 7.1 12.0 2.2 8.0 5.4 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.10 ERZ97766.1 - 6.5 6.3 14.6 1 8.8 1.6 3.3 2 1 1 3 3 3 0 Septum formation initiator Mito_carr PF00153.22 ERZ97769.1 - 0.0044 16.6 0.0 0.0052 16.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein Pkinase_Tyr PF07714.12 ERZ97775.1 - 7.9e-38 130.0 0.0 1.3e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97775.1 - 7e-35 120.4 0.2 2.1e-34 118.8 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain YL1 PF05764.8 ERZ97775.1 - 0.015 14.9 1.2 0.024 14.2 0.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DZR PF12773.2 ERZ97775.1 - 0.12 12.2 12.4 0.28 11.0 8.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon APH PF01636.18 ERZ97775.1 - 0.21 11.2 0.1 0.31 10.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Vasculin PF15337.1 ERZ97775.1 - 6.3 7.3 7.5 1.9 8.9 0.4 2.7 3 0 0 3 3 3 0 Vascular protein family Vasculin-like 1 DUF3336 PF11815.3 ERZ97776.1 - 4.1e-42 143.1 7.1 6.5e-42 142.4 4.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ERZ97776.1 - 1.1e-19 71.2 0.0 2.3e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Abhydrolase_3 PF07859.8 ERZ97776.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold ORF6C PF10552.4 ERZ97776.1 - 0.23 11.2 2.7 2.6 7.7 0.2 2.5 1 1 1 2 2 2 0 ORF6C domain Antimicrobial_7 PF08102.6 ERZ97777.1 - 0.0095 15.9 1.6 0.18 11.8 0.0 2.5 1 1 1 2 2 2 1 Scorpion antimicrobial peptide DapH_N PF08503.5 ERZ97777.1 - 0.023 14.8 0.5 0.071 13.2 0.4 1.9 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal COG5 PF10392.4 ERZ97777.1 - 0.027 14.4 2.3 0.03 14.2 0.6 1.9 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Cytadhesin_P30 PF07271.6 ERZ97777.1 - 0.71 9.0 7.8 0.042 13.1 0.6 2.3 2 1 1 3 3 3 0 Cytadhesin P30/P32 YlqD PF11068.3 ERZ97777.1 - 0.82 9.7 7.5 0.12 12.3 1.0 2.2 2 0 0 2 2 2 0 YlqD protein BMP2K_C PF15282.1 ERZ97777.1 - 7.9 6.5 10.4 0.87 9.7 0.8 2.2 2 0 0 2 2 2 0 BMP-2-inducible protein kinase C-terminus FAA_hydrolase PF01557.13 ERZ97778.1 - 5.4e-54 182.9 0.0 7e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family KH_2 PF07650.12 ERZ97778.1 - 0.0035 16.8 0.0 0.0079 15.7 0.0 1.6 1 0 0 1 1 1 1 KH domain RWD PF05773.17 ERZ97779.1 - 3.3e-23 81.7 2.9 8.4e-23 80.4 2.0 1.7 1 0 0 1 1 1 1 RWD domain Rotamase_2 PF13145.1 ERZ97779.1 - 0.79 10.3 8.3 2.1 8.9 5.3 1.9 2 0 0 2 2 2 0 PPIC-type PPIASE domain TFIID_90kDa PF04494.10 ERZ97780.1 - 0.0075 16.3 0.9 0.0085 16.1 0.6 1.1 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit UPF1_Zn_bind PF09416.5 ERZ97781.1 - 1e-74 249.1 4.9 1e-74 249.1 3.4 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 ERZ97781.1 - 3.3e-51 173.5 0.0 2.7e-25 88.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.1 ERZ97781.1 - 3.5e-33 115.1 6.1 7.8e-20 71.4 0.6 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.1 ERZ97781.1 - 4.1e-13 48.8 0.3 1e-12 47.6 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ERZ97781.1 - 1.6e-11 44.1 0.3 2.8e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 ERZ97781.1 - 9.9e-07 28.7 0.1 2e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 ERZ97781.1 - 5.6e-06 25.5 1.1 9.3e-05 21.5 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 ERZ97781.1 - 0.00069 19.3 0.0 0.0017 18.0 0.0 1.7 1 0 0 1 1 1 1 Helicase PIF1 PF05970.9 ERZ97781.1 - 0.0033 16.4 0.1 0.0072 15.3 0.0 1.5 1 1 0 1 1 1 1 PIF1-like helicase DEAD PF00270.24 ERZ97781.1 - 0.0049 16.3 0.2 0.0089 15.5 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_25 PF13481.1 ERZ97781.1 - 0.0086 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Ribosomal_S13_N PF08069.7 ERZ97781.1 - 0.011 15.5 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain KaiC PF06745.8 ERZ97781.1 - 0.031 13.3 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.1 ERZ97781.1 - 0.036 14.1 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 ERZ97781.1 - 0.048 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PhoH PF02562.11 ERZ97781.1 - 0.052 12.7 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein T2SE PF00437.15 ERZ97781.1 - 0.13 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.24 ERZ97781.1 - 0.17 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Methyltransf_31 PF13847.1 ERZ97782.1 - 2.6e-14 53.0 0.1 4.3e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ERZ97782.1 - 1.1e-11 44.4 0.0 1.6e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 ERZ97782.1 - 3.3e-11 43.5 0.0 8.4e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ97782.1 - 6.2e-11 42.8 0.0 1.8e-10 41.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ERZ97782.1 - 2.7e-09 37.0 0.0 5e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 ERZ97782.1 - 5.3e-08 32.2 0.0 7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_23 PF13489.1 ERZ97782.1 - 9.4e-08 31.9 0.0 2.8e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ97782.1 - 9.7e-07 29.1 0.0 2.1e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ERZ97782.1 - 3.3e-06 26.5 0.1 6e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.6 ERZ97782.1 - 3.9e-06 25.7 0.0 4.7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_25 PF13649.1 ERZ97782.1 - 3.8e-05 23.9 0.0 7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ERZ97782.1 - 0.00016 20.8 0.0 0.00022 20.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 ERZ97782.1 - 0.00016 21.7 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase TehB PF03848.9 ERZ97782.1 - 0.0038 16.4 0.8 0.011 14.9 0.6 1.8 1 1 0 1 1 1 1 Tellurite resistance protein TehB UPF0020 PF01170.13 ERZ97782.1 - 0.0044 16.6 0.1 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.1 ERZ97782.1 - 0.01 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 ERZ97782.1 - 0.013 16.2 0.0 0.027 15.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ97782.1 - 0.016 14.3 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 ERZ97782.1 - 0.019 14.4 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 Putative methyltransferase DOT1 PF08123.8 ERZ97782.1 - 0.036 13.3 0.0 0.071 12.4 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 TPR_11 PF13414.1 ERZ97783.1 - 2.1e-26 91.3 28.8 1e-06 28.2 0.1 5.7 5 1 0 6 6 5 5 TPR repeat TPR_2 PF07719.12 ERZ97783.1 - 7.9e-22 75.3 23.0 0.014 15.2 0.0 9.9 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ97783.1 - 9.1e-13 47.2 38.7 0.0033 16.9 0.0 10.1 10 1 0 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ97783.1 - 8.2e-11 40.8 41.7 0.004 16.8 0.1 9.3 9 1 1 10 10 9 5 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97783.1 - 6.9e-10 38.3 22.3 0.088 13.0 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97783.1 - 5.6e-09 36.4 0.0 0.18 12.5 0.0 5.5 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ97783.1 - 2e-08 34.4 0.2 0.22 11.9 0.1 4.7 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97783.1 - 1.2e-07 31.5 19.1 0.03 14.2 0.5 6.2 4 3 2 6 6 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97783.1 - 1.1e-06 28.7 35.1 5.1e-05 23.3 1.5 5.4 2 1 6 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.5 ERZ97783.1 - 5.1e-05 22.2 4.8 0.00031 19.6 1.7 2.5 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.1 ERZ97783.1 - 0.00017 21.1 5.5 0.63 9.9 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97783.1 - 0.00029 21.2 0.0 69 4.4 0.0 5.4 2 2 5 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ97783.1 - 0.00029 20.6 0.0 0.75 9.6 0.0 3.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ97783.1 - 0.016 15.5 8.2 22 5.7 0.0 6.5 8 0 0 8 8 7 0 Tetratricopeptide repeat zf-C3HC4_3 PF13920.1 ERZ97783.1 - 0.047 13.3 5.7 0.027 14.1 2.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ97783.1 - 0.84 9.4 9.0 0.19 11.5 3.2 2.3 2 0 0 2 2 2 0 zinc-RING finger domain UDPGT PF00201.13 ERZ97786.1 - 3.6e-19 68.6 0.0 5.9e-19 67.9 0.0 1.3 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ERZ97786.1 - 3.7e-07 29.9 0.0 4.8e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ERZ97786.1 - 8.6e-07 28.4 0.0 1.5e-06 27.6 0.0 1.3 2 0 0 2 2 2 1 Glycosyl transferase family 1 DUF212 PF02681.9 ERZ97786.1 - 0.095 12.4 0.1 1 9.0 0.0 2.1 2 0 0 2 2 2 0 Divergent PAP2 family Methyltransf_31 PF13847.1 ERZ97790.1 - 1.6e-07 31.0 0.3 1e-06 28.4 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ97790.1 - 1.8e-07 31.4 0.0 2.8e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ97790.1 - 2.5e-07 31.0 0.0 4.3e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ97790.1 - 8.5e-07 29.5 0.0 2e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ97790.1 - 1.4e-06 28.0 0.0 1.6e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ERZ97790.1 - 4.8e-06 26.6 0.0 4.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 ERZ97790.1 - 9.3e-06 24.8 0.0 1.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MetW PF07021.7 ERZ97790.1 - 0.00013 21.3 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.7 ERZ97790.1 - 0.00025 21.4 0.0 0.00039 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ERZ97790.1 - 0.0046 16.9 0.0 0.0089 16.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ97790.1 - 0.0092 15.1 0.0 0.013 14.6 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 ERZ97790.1 - 0.037 13.1 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 ERZ97790.1 - 0.06 12.7 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TehB PF03848.9 ERZ97790.1 - 0.12 11.4 0.1 0.18 10.9 0.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB p450 PF00067.17 ERZ97791.1 - 5.6e-90 302.0 0.1 6.9e-90 301.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4145 PF13643.1 ERZ97791.1 - 0.097 12.5 0.2 0.35 10.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) Hydrolase_like2 PF13246.1 ERZ97793.1 - 9.2e-14 51.1 0.0 9e-13 47.9 0.0 2.3 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ERZ97793.1 - 3.7e-12 46.8 0.6 1.6e-11 44.7 0.4 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ERZ97793.1 - 7.9e-10 39.5 0.3 1.9e-08 34.9 0.2 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ERZ97793.1 - 0.0066 16.0 1.0 0.0066 16.0 0.7 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ERZ97793.1 - 0.0078 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF3906 PF13046.1 ERZ97793.1 - 0.068 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) DASH_Dad3 PF08656.5 ERZ97794.1 - 7.6e-22 76.8 0.8 8.8e-22 76.5 0.6 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 Maelstrom PF13017.1 ERZ97794.1 - 0.14 11.5 1.9 0.16 11.4 1.3 1.1 1 0 0 1 1 1 0 piRNA pathway germ-plasm component HSP70 PF00012.15 ERZ97796.1 - 2e-05 22.7 0.0 0.00021 19.3 0.0 2.3 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ97796.1 - 0.00029 19.5 0.0 0.0074 14.9 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein E1_DerP2_DerF2 PF02221.10 ERZ97797.1 - 1e-05 25.8 0.4 1.2e-05 25.5 0.3 1.1 1 0 0 1 1 1 1 ML domain Imm15 PF15590.1 ERZ97800.1 - 0.03 13.4 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 15 SASRP1 PF15160.1 ERZ97800.1 - 0.033 13.4 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 rve_2 PF13333.1 ERZ97800.1 - 0.075 13.1 0.2 0.92 9.6 0.1 2.4 2 0 0 2 2 2 0 Integrase core domain Na_Ca_ex PF01699.19 ERZ97801.1 - 1.1e-07 31.5 6.3 1.1e-07 31.5 4.4 3.1 2 1 2 4 4 4 1 Sodium/calcium exchanger protein Fzo_mitofusin PF04799.8 ERZ97801.1 - 0.04 13.3 0.3 0.77 9.1 0.0 2.3 2 0 0 2 2 2 0 fzo-like conserved region YwiC PF14256.1 ERZ97801.1 - 1.1 9.2 8.9 0.49 10.4 0.4 2.6 3 0 0 3 3 3 0 YwiC-like protein DUF2636 PF11120.3 ERZ97801.1 - 3 7.3 5.4 0.59 9.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2636) ATPase_gene1 PF09527.5 ERZ97801.1 - 6.1 6.7 11.0 8.3 6.2 0.1 3.9 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit (ATPase_gene1) Glyco_transf_41 PF13844.1 ERZ97802.1 - 1.2e-95 320.2 3.1 1.7e-46 158.2 0.0 4.1 4 0 0 4 4 4 3 Glycosyl transferase family 41 TPR_11 PF13414.1 ERZ97802.1 - 5.5e-15 54.7 3.9 0.00099 18.7 0.0 4.7 4 0 0 4 4 4 4 TPR repeat TPR_2 PF07719.12 ERZ97802.1 - 4.1e-12 45.0 1.3 0.0053 16.5 0.0 5.7 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ97802.1 - 1.2e-09 38.3 0.0 0.021 15.1 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ97802.1 - 6.1e-09 35.1 3.8 0.1 12.2 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ97802.1 - 1.7e-08 34.3 0.0 0.02 15.4 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ97802.1 - 1e-05 26.0 0.0 1.7 9.3 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ97802.1 - 1.4e-05 24.9 4.9 0.024 14.5 0.1 4.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ97802.1 - 6.3e-05 22.4 7.7 1.2 9.0 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 ERZ97802.1 - 0.00055 20.0 1.1 0.36 11.0 0.0 3.8 2 2 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ERZ97802.1 - 0.0039 16.8 3.8 2.2 8.2 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ97802.1 - 0.0058 16.7 7.0 0.12 12.6 0.1 4.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 ERZ97802.1 - 0.081 11.9 0.2 25 3.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ERZ97802.1 - 0.74 9.7 3.1 2.6 8.0 0.2 3.3 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain IBN_N PF03810.14 ERZ97803.1 - 1.8e-16 59.8 4.0 2.6e-16 59.2 0.0 3.4 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.7 ERZ97803.1 - 0.0019 18.1 3.0 0.027 14.3 0.2 3.8 3 1 0 4 4 4 1 Exportin 1-like protein RPE65 PF03055.10 ERZ97804.1 - 1.8e-98 330.2 0.0 2.1e-98 329.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Dor1 PF04124.7 ERZ97806.1 - 8.9e-83 277.5 11.9 1.5e-82 276.8 8.3 1.3 1 0 0 1 1 1 1 Dor1-like family DUF2450 PF10475.4 ERZ97806.1 - 0.2 10.5 10.3 0.38 9.6 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Vps51 PF08700.6 ERZ97806.1 - 0.86 9.4 7.3 0.75 9.6 0.6 3.6 3 1 0 3 3 3 0 Vps51/Vps67 CLASP_N PF12348.3 ERZ97807.1 - 6.5e-82 274.2 0.8 9.3e-68 227.9 0.1 3.7 3 0 0 3 3 3 3 CLASP N terminal HEAT PF02985.17 ERZ97807.1 - 1.1e-12 46.8 6.8 0.029 14.4 0.0 9.8 11 0 0 11 11 11 2 HEAT repeat HEAT_EZ PF13513.1 ERZ97807.1 - 0.00016 22.0 6.8 20 5.8 0.0 7.1 7 0 0 7 7 7 1 HEAT-like repeat Ribosomal_S11 PF00411.14 ERZ97808.1 - 3.3e-09 36.8 0.1 5.7e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 NYD-SP28_assoc PF14775.1 ERZ97810.1 - 0.038 13.6 2.6 0.038 13.6 1.8 2.8 3 0 0 3 3 3 0 Sperm tail C-terminal domain AAA_15 PF13175.1 ERZ97810.1 - 0.14 11.1 12.6 0.22 10.5 8.8 1.2 1 0 0 1 1 1 0 AAA ATPase domain Exonuc_VII_L PF02601.10 ERZ97810.1 - 0.82 8.8 8.7 0.98 8.5 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Rotamase_2 PF13145.1 ERZ97810.1 - 1.5 9.4 7.4 2.6 8.7 5.1 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain AAA-ATPase_like PF09820.4 ERZ97812.1 - 1.1e-06 28.0 0.2 2.1e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_22 PF13401.1 ERZ97812.1 - 0.00047 20.2 0.1 0.0018 18.4 0.1 2.0 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ERZ97812.1 - 0.00071 19.3 0.1 0.59 9.7 0.1 3.3 3 0 0 3 3 3 1 Archaeal ATPase AAA PF00004.24 ERZ97812.1 - 0.017 15.3 0.0 0.04 14.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ97812.1 - 0.071 13.0 0.2 2.5 8.0 0.1 3.0 1 1 1 2 2 2 0 AAA ATPase domain zf-C2H2_2 PF12756.2 ERZ97813.1 - 0.024 14.7 0.6 0.036 14.1 0.4 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Ycf34 PF10718.4 ERZ97813.1 - 0.036 14.4 1.1 0.073 13.4 0.8 1.5 1 1 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 YebO PF13974.1 ERZ97816.1 - 0.0044 16.7 2.6 0.0044 16.7 1.8 2.0 2 0 0 2 2 2 1 YebO-like protein RIH_assoc PF08454.6 ERZ97816.1 - 0.0091 15.6 0.9 0.019 14.5 0.6 1.6 1 0 0 1 1 1 1 RyR and IP3R Homology associated FHIPEP PF00771.15 ERZ97816.1 - 0.054 11.8 5.9 0.061 11.6 4.1 1.0 1 0 0 1 1 1 0 FHIPEP family Sigma54_activ_2 PF14532.1 ERZ97816.1 - 0.21 11.6 1.6 0.43 10.6 0.6 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF1548 PF07579.6 ERZ97819.1 - 0.038 14.1 0.2 0.049 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) DUF4618 PF15397.1 ERZ97820.1 - 0.06 12.6 2.1 0.097 11.9 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) HDNR PF15115.1 ERZ97820.1 - 0.086 12.7 2.2 0.083 12.8 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function with conserved HDNR motif FliJ PF02050.11 ERZ97820.1 - 0.46 10.5 5.3 0.79 9.7 3.7 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein IL15 PF02372.10 ERZ97821.1 - 0.055 13.2 0.5 0.076 12.7 0.4 1.2 1 0 0 1 1 1 0 Interleukin 15 TLD PF07534.11 ERZ97822.1 - 4.5e-06 26.6 0.5 4.5e-06 26.6 0.4 1.7 2 0 0 2 2 2 1 TLD rve_2 PF13333.1 ERZ97822.1 - 0.14 12.2 1.7 0.16 12.0 0.2 1.8 2 0 0 2 2 2 0 Integrase core domain Fungal_trans PF04082.13 ERZ97823.1 - 4.2e-19 68.4 0.1 5.2e-19 68.1 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain YadA_anchor PF03895.10 ERZ97823.1 - 0.06 13.3 0.1 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 YadA-like C-terminal region Pkinase PF00069.20 ERZ97825.1 - 1.4e-10 40.8 0.0 1.7e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97825.1 - 3.2e-08 32.9 0.0 3.6e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Orthopox_A49R PF06489.6 ERZ97825.1 - 0.011 15.7 0.6 0.014 15.4 0.4 1.1 1 0 0 1 1 1 0 Orthopoxvirus A49R protein GFO_IDH_MocA PF01408.17 ERZ97825.1 - 0.061 13.8 0.0 0.097 13.1 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold zf-CCHC PF00098.18 ERZ97827.1 - 0.0021 17.8 3.5 0.0032 17.3 2.4 1.3 1 0 0 1 1 1 1 Zinc knuckle DUF515 PF04415.7 ERZ97827.1 - 0.0049 15.1 6.5 0.0048 15.1 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF515) zf-CCHC_4 PF14392.1 ERZ97827.1 - 0.0067 16.0 2.0 0.014 15.0 1.4 1.5 1 0 0 1 1 1 1 Zinc knuckle Cwf_Cwc_15 PF04889.7 ERZ97827.1 - 0.012 15.3 10.2 0.014 15.1 7.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-CCHC_6 PF15288.1 ERZ97827.1 - 0.034 13.8 8.8 0.066 12.9 6.1 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF164 PF02591.10 ERZ97827.1 - 0.04 13.7 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative zinc ribbon domain zf-H2C2 PF09337.5 ERZ97827.1 - 0.067 12.6 1.4 0.12 11.8 1.0 1.4 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Abhydrolase_3 PF07859.8 ERZ97828.1 - 2e-27 96.1 0.0 2.6e-24 85.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ERZ97828.1 - 0.002 17.8 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ERZ97828.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Y_phosphatase2 PF03162.8 ERZ97829.1 - 0.084 12.2 1.0 0.091 12.1 0.5 1.3 1 1 0 1 1 1 0 Tyrosine phosphatase family Pre-SET PF05033.11 ERZ97829.1 - 0.095 12.9 2.0 0.17 12.2 1.4 1.4 1 1 0 1 1 1 0 Pre-SET motif Metallophos PF00149.23 ERZ97830.1 - 1.3e-06 27.9 1.8 4.1e-06 26.3 1.2 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Polysacc_synt PF01943.12 ERZ97831.1 - 0.036 13.3 4.0 0.05 12.8 2.7 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1129 PF06570.6 ERZ97832.1 - 4.1 6.6 7.3 1.7 7.9 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) TraH PF06122.6 ERZ97834.1 - 0.035 12.9 2.8 0.037 12.8 1.9 1.0 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein Agro_virD5 PF04730.7 ERZ97834.1 - 0.072 11.1 3.7 0.082 10.9 2.6 1.0 1 0 0 1 1 1 0 Agrobacterium VirD5 protein DUF4316 PF14195.1 ERZ97834.1 - 0.17 11.9 7.3 0.24 11.5 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) ADH_zinc_N PF00107.21 ERZ97835.1 - 2.1e-19 69.3 0.0 4.2e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ERZ97835.1 - 0.0094 16.8 0.0 0.033 15.0 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.3 ERZ97835.1 - 0.031 13.4 0.0 4.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2855) DEAD PF00270.24 ERZ97836.1 - 3e-21 75.6 0.1 3.4e-19 68.9 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ97836.1 - 6.3e-13 48.3 0.1 2.6e-10 40.0 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 ERZ97836.1 - 4.9e-05 23.2 0.0 0.00017 21.5 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ORF6C PF10552.4 ERZ97836.1 - 0.082 12.6 0.1 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 ORF6C domain SEA PF01390.15 ERZ97839.1 - 0.031 13.9 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 SEA domain zf-RING_2 PF13639.1 ERZ97840.1 - 0.0003 20.5 1.8 0.0003 20.5 1.3 1.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 ERZ97840.1 - 0.00086 18.9 3.6 0.0018 17.9 0.9 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ERZ97840.1 - 0.0057 16.6 4.0 0.0082 16.1 1.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ERZ97840.1 - 0.019 15.0 0.4 0.044 13.9 0.3 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ERZ97840.1 - 0.046 13.3 1.1 0.046 13.3 0.7 1.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.16 ERZ97840.1 - 0.052 13.4 0.2 0.46 10.4 0.0 2.2 2 0 0 2 2 2 0 IBR domain zf-Nse PF11789.3 ERZ97840.1 - 0.091 12.2 2.1 0.23 11.0 0.8 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.20 ERZ97840.1 - 0.092 12.4 1.2 2.1 8.0 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Birna_VP3 PF01767.11 ERZ97842.1 - 0.047 13.3 0.1 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 Birnavirus VP3 protein La PF05383.12 ERZ97842.1 - 0.23 11.2 1.2 28 4.5 0.4 2.8 2 1 0 2 2 2 0 La domain DUF1631 PF07793.6 ERZ97843.1 - 9.2 4.2 7.2 14 3.6 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) T4_deiodinase PF00837.12 ERZ97845.1 - 5.4e-18 64.8 0.0 6.6e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Iodothyronine deiodinase TPR_14 PF13428.1 ERZ97845.1 - 0.0029 18.1 0.1 0.007 16.9 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2847 PF11009.3 ERZ97845.1 - 0.021 14.4 0.0 1.9 8.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2847) TPR_19 PF14559.1 ERZ97845.1 - 0.15 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ubiquitin PF00240.18 ERZ97846.1 - 2.2e-99 324.8 33.5 1.5e-26 91.5 0.1 7.7 7 1 0 7 7 7 7 Ubiquitin family Rad60-SLD PF11976.3 ERZ97846.1 - 3.3e-49 164.4 24.5 3.3e-14 52.3 0.0 7.2 7 0 0 7 7 7 7 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ERZ97846.1 - 1.3e-10 41.4 17.7 0.003 17.7 0.0 7.4 3 3 2 5 5 5 3 Ubiquitin-like domain UN_NPL4 PF11543.3 ERZ97846.1 - 0.00021 21.4 3.4 4.7 7.5 0.0 5.4 6 0 0 6 6 6 1 Nuclear pore localisation protein NPL4 Telomere_Sde2 PF13019.1 ERZ97846.1 - 0.0035 17.0 0.0 0.04 13.6 0.0 2.6 3 0 0 3 3 3 1 Telomere stability and silencing Antitoxin-MazE PF04014.13 ERZ97846.1 - 0.011 15.4 0.0 0.17 11.6 0.0 2.4 2 0 0 2 2 2 0 Antidote-toxin recognition MazE Iron_permease PF04120.7 ERZ97846.1 - 0.61 9.6 5.7 2.8 7.5 0.1 2.9 3 0 0 3 3 3 0 Low affinity iron permease FtsL PF04999.8 ERZ97847.1 - 0.016 14.9 1.3 0.018 14.7 0.9 1.0 1 0 0 1 1 1 0 Cell division protein FtsL YTH PF04146.10 ERZ97847.1 - 0.044 13.3 0.1 0.044 13.3 0.1 1.0 1 0 0 1 1 1 0 YT521-B-like domain DUF1752 PF08550.5 ERZ97847.1 - 0.15 11.6 1.9 0.18 11.4 0.3 1.9 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1752) Lebercilin PF15619.1 ERZ97848.1 - 0.0038 16.6 16.8 0.52 9.6 0.2 3.1 2 1 1 3 3 3 2 Ciliary protein causing Leber congenital amaurosis disease DUF4527 PF15030.1 ERZ97848.1 - 0.063 12.5 5.2 0.041 13.1 2.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4527) ABC_tran_2 PF12848.2 ERZ97848.1 - 0.76 9.6 5.8 1.1 9.1 3.2 1.8 1 1 0 1 1 1 0 ABC transporter Mnd1 PF03962.10 ERZ97848.1 - 1.1 8.9 10.3 3.1 7.4 4.9 2.3 2 0 0 2 2 2 0 Mnd1 family DUF1664 PF07889.7 ERZ97848.1 - 1.1 9.0 7.4 22 4.8 2.7 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 ERZ97848.1 - 1.9 6.8 15.5 0.93 7.8 7.3 1.7 1 1 0 2 2 2 0 AAA domain V_ATPase_I PF01496.14 ERZ97848.1 - 3.4 5.4 6.0 5.8 4.6 4.2 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.20 ERZ97848.1 - 4.4 7.5 15.0 3.7 7.7 5.5 2.2 2 0 0 2 2 2 0 Syntaxin Antifungal_pept PF11410.3 ERZ97849.1 - 0.83 9.7 3.9 0.65 10.1 0.4 2.0 2 0 0 2 2 2 0 Antifungal peptide Complex1_LYR_2 PF13233.1 ERZ97853.1 - 0.087 13.3 0.0 0.41 11.1 0.0 2.1 1 1 0 1 1 1 0 Complex1_LYR-like DUF4077 PF13295.1 ERZ97855.1 - 0.038 13.7 0.5 0.043 13.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4077) DEAD PF00270.24 ERZ97862.1 - 9.2e-06 25.2 0.0 6.5e-05 22.4 0.0 2.2 1 1 0 2 2 2 1 DEAD/DEAH box helicase FRG2 PF15315.1 ERZ97862.1 - 0.17 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 TAA-Trp-ring PF15401.1 ERZ97863.1 - 0.008 16.3 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 Tryptophan-ring motif of head of Trimeric autotransporter adhesin NifZ PF04319.8 ERZ97863.1 - 0.11 11.9 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 NifZ domain DUF908 PF06012.7 ERZ97865.1 - 0.033 13.4 0.0 0.049 12.9 0.0 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) Nop14 PF04147.7 ERZ97865.1 - 0.041 11.8 28.1 0.045 11.6 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family Spore_coat_CotO PF14153.1 ERZ97865.1 - 0.061 12.7 8.3 0.069 12.5 5.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO SDA1 PF05285.7 ERZ97865.1 - 0.089 12.0 25.2 0.11 11.7 17.5 1.1 1 0 0 1 1 1 0 SDA1 Hid1 PF12722.2 ERZ97865.1 - 0.11 10.1 5.8 0.11 10.1 4.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.9 ERZ97865.1 - 0.35 8.8 17.3 0.39 8.7 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.1 ERZ97865.1 - 0.74 8.2 5.7 0.9 7.9 3.9 1.1 1 0 0 1 1 1 0 Raftlin Upf2 PF04050.9 ERZ97865.1 - 1.8 8.2 26.9 3.1 7.5 18.6 1.5 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Ycf1 PF05758.7 ERZ97865.1 - 1.9 6.0 8.4 2.2 5.8 5.8 1.2 1 0 0 1 1 1 0 Ycf1 DUF2722 PF10846.3 ERZ97865.1 - 5.8 5.8 10.8 8.1 5.3 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1510 PF07423.6 ERZ97865.1 - 7.2 5.9 24.9 10 5.4 17.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pkinase PF00069.20 ERZ97867.1 - 1.3e-36 126.0 2.5 3.2e-36 124.8 1.7 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97867.1 - 1.8e-31 109.1 0.0 3e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EcoEI_R_C PF08463.5 ERZ97867.1 - 0.013 15.4 0.3 1.4 8.7 0.1 2.5 2 0 0 2 2 2 0 EcoEI R protein C-terminal Tbf5 PF06331.7 ERZ97867.1 - 0.14 11.9 0.8 0.43 10.3 0.6 1.8 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 APH PF01636.18 ERZ97867.1 - 0.17 11.6 0.5 0.28 10.8 0.4 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Perm-CXXC PF15629.1 ERZ97867.1 - 0.45 10.5 6.3 0.54 10.3 0.3 2.4 2 0 0 2 2 2 0 Permuted single zf-CXXC unit LRR_6 PF13516.1 ERZ97868.1 - 1.6e-10 39.8 8.1 0.069 13.2 0.0 5.5 5 0 0 5 5 5 4 Leucine Rich repeat LRR_8 PF13855.1 ERZ97868.1 - 1.3e-06 28.0 10.0 0.00022 20.8 0.1 3.6 2 2 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ERZ97868.1 - 9.4e-05 21.9 8.5 8.1 6.9 0.1 5.4 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ERZ97868.1 - 0.00014 21.4 3.5 60 4.5 0.0 5.4 5 0 0 5 5 5 0 Leucine rich repeat LRR_4 PF12799.2 ERZ97868.1 - 0.0002 20.8 10.1 0.066 12.8 0.0 3.6 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) DUF1462 PF07315.6 ERZ97870.1 - 0.088 12.7 0.2 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) Sel1 PF08238.7 ERZ97871.1 - 1.3e-75 248.1 33.5 6.1e-11 42.5 0.2 11.4 11 0 0 11 11 11 11 Sel1 repeat Pkinase PF00069.20 ERZ97871.1 - 5.7e-45 153.4 0.2 1.3e-44 152.3 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97871.1 - 3.7e-44 150.7 0.0 5.6e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ97871.1 - 1.5e-05 24.4 0.1 4.2e-05 22.9 0.1 1.7 1 0 0 1 1 1 1 RIO1 family TPR_6 PF13174.1 ERZ97871.1 - 6.3e-05 23.1 7.9 6.6 7.4 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat Kdo PF06293.9 ERZ97871.1 - 0.00081 18.5 0.3 0.0018 17.3 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ97871.1 - 0.011 14.7 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ERZ97871.1 - 0.058 13.1 0.4 0.27 10.9 0.5 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-FPG_IleRS PF06827.9 ERZ97871.1 - 0.15 11.7 0.3 0.37 10.4 0.2 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS DUF2661 PF10860.3 ERZ97872.1 - 0.31 11.2 3.5 0.57 10.3 2.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2661) GRP PF07172.6 ERZ97873.1 - 3.4 8.2 21.4 1e+02 3.5 14.8 2.1 1 1 0 1 1 1 0 Glycine rich protein family Lipocalin_7 PF14651.1 ERZ97875.1 - 0.039 13.6 0.1 0.046 13.4 0.1 1.1 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DUF3752 PF12572.3 ERZ97876.1 - 0.12 12.5 0.0 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3752) DcpS_C PF11969.3 ERZ97877.1 - 0.0011 19.2 1.0 0.0084 16.3 0.6 2.0 1 1 1 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding RicinB_lectin_2 PF14200.1 ERZ97880.1 - 1.3e-08 35.1 7.6 0.00049 20.4 0.2 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ERZ97880.1 - 0.0011 19.0 6.1 0.35 10.9 2.8 2.9 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain Amidase_3 PF01520.13 ERZ97880.1 - 0.067 12.9 0.6 0.15 11.8 0.2 1.8 2 0 0 2 2 2 0 N-acetylmuramoyl-L-alanine amidase IncA PF04156.9 ERZ97881.1 - 0.0022 17.5 6.4 0.0022 17.5 4.4 1.8 2 0 0 2 2 2 1 IncA protein Nup54 PF13874.1 ERZ97881.1 - 0.17 11.5 10.4 0.089 12.4 0.9 3.5 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 DUF778 PF05608.7 ERZ97881.1 - 0.5 10.2 6.8 0.059 13.3 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF778) DUF730 PF05325.6 ERZ97881.1 - 4.9 6.9 8.6 0.45 10.3 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF730) HMG_box_2 PF09011.5 ERZ97882.1 - 0.0031 17.8 2.9 0.0095 16.2 0.8 2.4 1 1 1 2 2 2 1 HMG-box domain HMG_box PF00505.14 ERZ97882.1 - 0.068 13.4 0.6 0.34 11.1 0.3 2.4 1 1 0 1 1 1 0 HMG (high mobility group) box DUF336 PF03928.9 ERZ97885.1 - 1.1e-24 86.6 0.0 1.5e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF336) Peroxidase_2 PF01328.12 ERZ97886.1 - 1.8e-26 92.5 0.2 7.2e-26 90.6 0.1 1.7 1 1 0 1 1 1 1 Peroxidase, family 2 Brix PF04427.13 ERZ97887.1 - 3.5e-48 163.7 0.7 5.8e-48 163.0 0.5 1.3 1 0 0 1 1 1 1 Brix domain Mgr1 PF08602.5 ERZ97887.1 - 0.22 10.5 2.4 0.33 9.9 1.7 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Alpha-amylase_C PF02806.13 ERZ97888.1 - 4.5e-23 81.1 0.1 1.4e-22 79.6 0.1 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.13 ERZ97888.1 - 3e-16 59.2 0.0 6.3e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.19 ERZ97888.1 - 3.9e-15 56.0 0.2 4.2e-13 49.3 0.0 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain SPRY PF00622.23 ERZ97890.1 - 1.1e-16 61.0 1.6 1.7e-16 60.4 1.1 1.3 1 0 0 1 1 1 1 SPRY domain DNA_pol_B_3 PF08408.5 ERZ97890.1 - 0.067 13.0 3.0 0.13 12.0 2.1 1.4 1 0 0 1 1 1 0 DNA polymerase family B viral insert CNRIP1 PF15043.1 ERZ97890.1 - 0.12 11.6 0.1 0.46 9.7 0.1 2.0 2 1 1 3 3 3 0 CB1 cannabinoid receptor-interacting protein 1 Sec5 PF15469.1 ERZ97892.1 - 0.044 13.4 0.5 0.089 12.5 0.3 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5 CTP_transf_1 PF01148.15 ERZ97892.1 - 6.7 6.2 24.0 0.11 12.1 6.1 2.1 2 0 0 2 2 2 0 Cytidylyltransferase family Cytochrome-c551 PF10643.4 ERZ97892.1 - 8.4 5.6 9.7 0.43 9.8 2.3 2.0 2 1 1 3 3 3 0 Photosystem P840 reaction-centre cytochrome c-551 CTP_transf_1 PF01148.15 ERZ97893.1 - 0.1 12.2 6.0 0.12 12.0 4.2 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family Peptidase_M50 PF02163.17 ERZ97893.1 - 0.22 10.4 1.3 0.26 10.2 0.9 1.1 1 0 0 1 1 1 0 Peptidase family M50 Steroid_dh PF02544.11 ERZ97893.1 - 0.24 11.1 2.0 0.44 10.3 0.1 2.0 1 1 1 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase zf-DHHC PF01529.15 ERZ97893.1 - 0.52 9.6 3.9 0.64 9.4 2.7 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase IncA PF04156.9 ERZ97895.1 - 5.2e-05 22.9 4.5 0.00012 21.7 3.2 1.5 1 1 0 1 1 1 1 IncA protein DUF641 PF04859.7 ERZ97895.1 - 0.00063 19.5 4.0 0.3 10.8 0.1 2.1 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) SlyX PF04102.7 ERZ97895.1 - 0.00065 20.0 5.0 0.091 13.1 0.3 2.3 2 0 0 2 2 2 2 SlyX FlaC_arch PF05377.6 ERZ97895.1 - 0.0017 18.2 2.6 0.0017 18.2 1.8 2.2 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) Sigma70_ner PF04546.8 ERZ97895.1 - 0.0084 15.7 3.6 0.086 12.4 0.2 2.0 2 0 0 2 2 2 1 Sigma-70, non-essential region DUF489 PF04356.7 ERZ97895.1 - 0.011 15.3 2.0 0.011 15.3 1.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) DivIC PF04977.10 ERZ97895.1 - 0.039 13.4 3.7 0.072 12.5 1.4 2.1 2 0 0 2 2 2 0 Septum formation initiator EAP30 PF04157.11 ERZ97895.1 - 0.052 12.7 5.6 0.067 12.3 0.2 2.1 2 0 0 2 2 2 0 EAP30/Vps36 family COMP PF11598.3 ERZ97895.1 - 0.12 12.4 1.3 0.16 12.0 0.4 1.6 2 0 0 2 2 1 0 Cartilage oligomeric matrix protein Prefoldin PF02996.12 ERZ97895.1 - 0.13 11.9 4.7 3.4 7.3 0.7 2.3 2 0 0 2 2 2 0 Prefoldin subunit HeLo PF14479.1 ERZ97895.1 - 0.16 11.7 2.6 0.48 10.1 1.8 1.7 1 1 0 1 1 1 0 Prion-inhibition and propagation DUF334 PF03904.8 ERZ97895.1 - 0.26 10.5 11.9 0.12 11.6 6.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF334) Nup54 PF13874.1 ERZ97895.1 - 0.3 10.7 6.9 0.29 10.8 0.3 2.2 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 POX PF07526.6 ERZ97895.1 - 0.61 10.3 5.3 6.9 6.8 0.2 2.1 1 1 1 2 2 2 0 Associated with HOX Spc7 PF08317.6 ERZ97895.1 - 0.75 8.4 12.2 0.27 9.8 2.2 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 ERZ97895.1 - 1.3 8.7 9.2 0.084 12.6 1.3 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.14 ERZ97895.1 - 1.9 6.2 9.0 4.1 5.1 6.3 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 ERZ97895.1 - 3.1 8.1 10.6 0.75 10.1 3.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) UPF0233 PF06781.7 ERZ97896.1 - 0.039 13.5 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) NTase_sub_bind PF08780.6 ERZ97896.1 - 0.051 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like Orthopox_35kD PF02250.10 ERZ97896.1 - 0.069 12.4 0.1 0.069 12.4 0.1 1.2 1 0 0 1 1 1 0 35kD major secreted virus protein Spore_GerAC PF05504.6 ERZ97898.1 - 0.042 13.6 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Mob1_phocein PF03637.12 ERZ97899.1 - 0.042 13.5 0.1 0.074 12.7 0.1 1.4 1 0 0 1 1 1 0 Mob1/phocein family eIF-3c_N PF05470.7 ERZ97899.1 - 0.058 11.4 14.4 0.074 11.1 10.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_viral_N PF00242.12 ERZ97899.1 - 1.8 7.5 13.9 2.2 7.1 9.7 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain RNase_H PF00075.19 ERZ97902.1 - 6.1e-10 39.5 0.0 9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 RNase H DUF4413 PF14372.1 ERZ97904.1 - 0.0049 16.8 1.5 0.051 13.5 1.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4413) Syntaxin_2 PF14523.1 ERZ97904.1 - 0.23 11.5 4.4 0.26 11.3 0.7 2.2 2 0 0 2 2 2 0 Syntaxin-like protein BTB PF00651.26 ERZ97905.1 - 1.2e-08 34.9 0.0 1.6e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C3Hc3H PF13891.1 ERZ97908.1 - 0.045 13.8 2.0 0.11 12.5 1.4 1.7 1 0 0 1 1 1 0 Potential DNA-binding domain EF1G PF00647.14 ERZ97909.1 - 0.037 13.7 0.8 0.095 12.4 0.6 1.7 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain Toprim_N PF08275.6 ERZ97910.1 - 0.0073 16.2 0.3 0.01 15.7 0.2 1.2 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain Antimicrobial14 PF08109.6 ERZ97910.1 - 0.25 11.1 0.1 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 Lactocin 705 family Pkinase PF00069.20 ERZ97911.1 - 9.1e-71 238.0 0.0 1.7e-70 237.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97911.1 - 1.4e-55 188.1 0.0 2.4e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.17 ERZ97911.1 - 6.3e-08 32.2 10.2 1.5e-07 31.0 7.1 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.1 ERZ97911.1 - 9.5e-06 24.7 0.0 0.0005 19.1 0.0 2.2 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 ERZ97911.1 - 0.00079 18.8 0.4 0.0021 17.4 0.3 1.8 1 0 0 1 1 1 1 RIO1 family PHD PF00628.24 ERZ97911.1 - 0.021 14.5 8.9 0.045 13.4 6.2 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 ERZ97911.1 - 0.17 11.6 8.7 0.34 10.6 6.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 TFIIF_alpha PF05793.7 ERZ97911.1 - 0.53 8.5 31.6 0.91 7.8 21.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Utp14 PF04615.8 ERZ97911.1 - 1.3 7.0 33.1 2.1 6.4 23.0 1.2 1 0 0 1 1 1 0 Utp14 protein Neur_chan_memb PF02932.11 ERZ97911.1 - 3.4 7.4 8.3 8.8 6.1 5.7 1.8 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BUD22 PF09073.5 ERZ97911.1 - 6.8 5.6 28.6 14 4.6 19.8 1.5 1 0 0 1 1 1 0 BUD22 TLD PF07534.11 ERZ97912.1 - 2.1e-09 37.5 2.4 9.8e-09 35.3 1.7 2.0 1 1 0 1 1 1 1 TLD BTB PF00651.26 ERZ97914.1 - 2.8e-18 65.9 0.4 7.3e-18 64.5 0.3 1.7 1 1 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.20 ERZ97915.1 - 0.0031 16.6 0.2 0.0031 16.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Plasmid_parti PF01672.11 ERZ97915.1 - 0.06 13.7 0.1 0.07 13.5 0.0 1.1 1 0 0 1 1 1 0 Putative plasmid partition protein Pkinase_Tyr PF07714.12 ERZ97915.1 - 0.094 11.7 0.1 0.16 11.0 0.1 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ97916.1 - 0.14 11.1 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2344 PF10105.4 ERZ97917.1 - 0.0046 16.4 0.1 0.0096 15.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2344) Myb_DNA-bind_6 PF13921.1 ERZ97918.1 - 7.5 6.7 10.6 5.6 7.1 0.5 4.2 5 0 0 5 5 5 0 Myb-like DNA-binding domain RyR PF02026.11 ERZ97920.1 - 0.1 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 RyR domain PMT_2 PF13231.1 ERZ97924.1 - 0.053 13.4 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase F-box-like PF12937.2 ERZ97926.1 - 1.7e-10 40.4 1.1 5.9e-10 38.7 0.8 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ97926.1 - 5.9e-08 32.1 3.2 4.8e-07 29.2 0.3 3.1 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.1 ERZ97926.1 - 0.0081 15.8 18.9 0.011 15.5 1.0 6.1 5 1 4 9 9 9 2 Leucine rich repeat RPAP3_C PF13877.1 ERZ97926.1 - 0.15 12.0 1.6 0.64 10.0 1.1 2.2 1 1 0 1 1 1 0 Potential Monad-binding region of RPAP3 LRR_4 PF12799.2 ERZ97926.1 - 0.22 11.1 22.8 3.1 7.5 5.8 7.1 6 1 3 9 9 9 0 Leucine Rich repeats (2 copies) DUF717 PF05338.7 ERZ97926.1 - 0.87 9.5 8.7 3.8 7.5 0.1 5.0 4 1 1 5 5 5 0 Protein of unknown function (DUF717) LRR_7 PF13504.1 ERZ97926.1 - 5.5 7.6 13.0 64 4.4 0.4 6.6 4 1 1 5 5 5 0 Leucine rich repeat LRR_6 PF13516.1 ERZ97926.1 - 7 7.0 16.8 8.4 6.8 1.3 6.8 8 0 0 8 8 8 0 Leucine Rich repeat IncA PF04156.9 ERZ97927.1 - 0.00089 18.9 7.7 0.0022 17.6 4.9 1.9 1 1 0 1 1 1 1 IncA protein FlaC_arch PF05377.6 ERZ97927.1 - 0.0028 17.5 2.6 0.0028 17.5 1.8 2.3 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) DUF641 PF04859.7 ERZ97927.1 - 0.0061 16.3 3.4 0.9 9.2 0.5 2.5 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) COMP PF11598.3 ERZ97927.1 - 0.091 12.8 0.5 0.27 11.3 0.4 1.8 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein EAP30 PF04157.11 ERZ97927.1 - 0.13 11.4 5.2 0.16 11.0 0.2 2.4 2 0 0 2 2 2 0 EAP30/Vps36 family DUF2087 PF09860.4 ERZ97927.1 - 0.26 11.0 2.0 2.6 7.8 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) SlyX PF04102.7 ERZ97927.1 - 0.31 11.4 7.4 2.6 8.4 0.2 2.8 3 0 0 3 3 3 0 SlyX DUF489 PF04356.7 ERZ97927.1 - 0.56 9.7 3.4 0.67 9.5 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF489) DivIC PF04977.10 ERZ97927.1 - 0.63 9.5 4.8 0.18 11.2 0.4 2.3 2 0 0 2 2 2 0 Septum formation initiator Allexi_40kDa PF05549.6 ERZ97927.1 - 7.8 5.6 11.0 1.8 7.7 4.1 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein V_ATPase_I PF01496.14 ERZ97927.1 - 8.4 4.1 9.1 5.1 4.8 5.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF334 PF03904.8 ERZ97927.1 - 9.6 5.4 16.1 0.35 10.1 6.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF334) Lipoprotein_9 PF03180.9 ERZ97928.1 - 0.04 12.8 0.0 0.042 12.7 0.0 1.0 1 0 0 1 1 1 0 NLPA lipoprotein Pkinase PF00069.20 ERZ97929.1 - 0.035 13.2 0.1 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain zf-CCHC_6 PF15288.1 ERZ97931.1 - 0.022 14.3 3.4 0.022 14.3 2.4 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.1 ERZ97931.1 - 0.17 11.5 3.5 0.28 10.8 2.1 1.6 1 1 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 ERZ97931.1 - 1.1 9.3 11.7 0.27 11.2 5.2 2.2 2 1 0 2 2 2 0 Zinc knuckle Ribosomal_S22 PF08136.6 ERZ97932.1 - 0.14 12.3 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 30S ribosomal protein subunit S22 family DUF3684 PF12449.3 ERZ97933.1 - 1.1e-90 304.7 8.8 7.3e-44 149.7 0.7 3.0 2 1 1 3 3 3 3 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ERZ97933.1 - 4.9e-07 29.4 0.0 1.2e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ERZ97933.1 - 0.021 14.5 0.0 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tox-SHH PF15652.1 ERZ97933.1 - 0.07 13.7 0.2 0.7 10.5 0.1 2.5 2 0 0 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature MIS13 PF08202.6 ERZ97936.1 - 2.3e-46 158.2 9.7 2.3e-46 158.2 6.7 1.8 2 0 0 2 2 2 1 Mis12-Mtw1 protein family DapB_C PF05173.9 ERZ97936.1 - 0.012 15.3 0.3 0.025 14.3 0.2 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, C-terminus Muted PF14942.1 ERZ97937.1 - 2.5e-13 50.1 8.2 2.9e-13 49.9 5.7 1.0 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein Tropomyosin PF00261.15 ERZ97937.1 - 0.0022 17.0 8.1 0.0033 16.5 5.6 1.3 1 0 0 1 1 1 1 Tropomyosin DFF40 PF09230.5 ERZ97937.1 - 0.0043 16.4 1.1 0.007 15.7 0.8 1.4 1 0 0 1 1 1 1 DNA fragmentation factor 40 kDa ATP-synt_S1 PF05827.7 ERZ97937.1 - 0.043 13.1 0.0 0.42 9.8 0.0 1.8 1 1 1 2 2 2 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Seryl_tRNA_N PF02403.17 ERZ97937.1 - 0.059 13.4 9.1 0.053 13.5 4.7 2.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AATF-Che1 PF13339.1 ERZ97937.1 - 0.069 13.3 4.6 0.1 12.7 2.9 1.5 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Gemini_AL3 PF01407.12 ERZ97937.1 - 0.08 12.4 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Geminivirus AL3 protein FliT PF05400.8 ERZ97937.1 - 0.091 13.1 4.4 0.19 12.1 3.1 1.6 1 1 0 1 1 1 0 Flagellar protein FliT FANCI_S3 PF14677.1 ERZ97937.1 - 0.13 11.6 2.9 1.5 8.1 0.2 2.3 1 1 0 2 2 2 0 FANCI solenoid 3 IF-2B PF01008.12 ERZ97937.1 - 0.17 10.8 1.5 0.21 10.5 0.4 1.5 1 1 1 2 2 2 0 Initiation factor 2 subunit family Cluap1 PF10234.4 ERZ97937.1 - 0.19 10.9 10.8 0.26 10.4 7.5 1.5 1 1 0 1 1 1 0 Clusterin-associated protein-1 TPR_MLP1_2 PF07926.7 ERZ97937.1 - 0.21 11.2 6.8 0.43 10.3 4.7 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mod_r PF07200.8 ERZ97937.1 - 0.24 11.3 7.8 0.16 11.9 3.9 1.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF342 PF03961.8 ERZ97937.1 - 0.31 9.4 4.3 0.34 9.2 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 ERZ97937.1 - 0.42 10.1 6.7 0.56 9.7 4.2 1.5 1 1 0 1 1 1 0 IncA protein ISG65-75 PF11727.3 ERZ97937.1 - 0.61 9.0 4.6 0.42 9.6 2.1 1.5 1 1 1 2 2 2 0 Invariant surface glycoprotein CENP-H PF05837.7 ERZ97937.1 - 0.99 9.6 7.3 0.51 10.5 2.9 2.0 2 1 1 3 3 3 0 Centromere protein H (CENP-H) LMP PF04778.7 ERZ97937.1 - 2.2 7.9 9.5 14 5.3 0.4 3.2 1 1 2 3 3 3 0 LMP repeated region Mnd1 PF03962.10 ERZ97937.1 - 6.5 6.3 10.4 12 5.4 4.8 2.2 1 1 1 2 2 2 0 Mnd1 family GrpE PF01025.14 ERZ97937.1 - 6.6 6.2 12.0 5.2 6.5 5.9 2.0 1 1 1 2 2 2 0 GrpE rRNA_proc-arch PF13234.1 ERZ97938.1 - 2.1e-81 273.0 0.8 2.1e-81 273.0 0.6 1.9 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.7 ERZ97938.1 - 2.2e-55 186.6 0.3 4.6e-55 185.6 0.2 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 ERZ97938.1 - 7.3e-22 77.6 0.0 4.5e-21 75.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ97938.1 - 2.7e-08 33.5 0.0 7.3e-08 32.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain T2SE PF00437.15 ERZ97938.1 - 0.015 14.1 0.0 0.03 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.1 ERZ97938.1 - 0.14 11.9 0.0 0.52 10.1 0.0 1.9 2 0 0 2 2 2 0 Part of AAA domain Pkip-1 PF06878.6 ERZ97939.1 - 0.0028 17.5 0.6 0.0049 16.7 0.4 1.4 1 0 0 1 1 1 1 Pkip-1 protein YebO PF13974.1 ERZ97939.1 - 0.079 12.7 1.8 0.15 11.8 1.3 1.6 1 0 0 1 1 1 0 YebO-like protein AAA_35 PF14516.1 ERZ97940.1 - 1.6e-10 40.1 0.0 3.4e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_16 PF13191.1 ERZ97940.1 - 4.6e-06 26.7 0.1 0.00051 20.0 0.0 3.5 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 ERZ97940.1 - 0.00012 22.1 0.1 0.00058 20.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ97940.1 - 0.00032 20.5 1.6 0.0052 16.6 0.1 3.3 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.5 ERZ97940.1 - 0.0013 18.0 0.0 0.009 15.2 0.0 2.2 2 0 0 2 2 2 1 Chromatin associated protein KTI12 PDDEXK_3 PF13366.1 ERZ97940.1 - 0.0018 18.3 0.2 0.0043 17.0 0.2 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Arch_ATPase PF01637.13 ERZ97940.1 - 0.0035 17.0 1.7 0.0053 16.4 0.0 2.2 3 0 0 3 3 3 1 Archaeal ATPase Thymidylate_kin PF02223.12 ERZ97940.1 - 0.033 13.5 0.2 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA_17 PF13207.1 ERZ97940.1 - 0.3 11.9 2.8 12 6.7 0.0 3.3 3 1 0 3 3 3 0 AAA domain Sterile PF03015.14 ERZ97942.1 - 0.13 12.5 2.3 0.5 10.6 0.1 2.8 3 0 0 3 3 3 0 Male sterility protein FlxA PF14282.1 ERZ97942.1 - 2.6 8.0 15.2 0.12 12.2 0.3 3.5 3 1 1 4 4 4 0 FlxA-like protein GP46 PF07409.7 ERZ97943.1 - 0.0048 16.1 0.1 1.6 8.0 0.0 2.5 2 0 0 2 2 2 2 Phage protein GP46 DUF2789 PF10982.3 ERZ97943.1 - 0.013 15.5 0.9 20 5.3 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) COP23 PF14218.1 ERZ97943.1 - 0.045 13.3 0.0 12 5.4 0.0 2.5 2 0 0 2 2 2 0 Circadian oscillating protein COP23 Mistic PF11458.3 ERZ97943.1 - 0.053 13.9 2.2 1.4 9.3 0.1 2.6 2 0 0 2 2 2 0 Membrane-integrating protein Mistic TraT PF05818.7 ERZ97943.1 - 0.093 12.1 3.3 5 6.4 0.4 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF2120 PF09893.4 ERZ97943.1 - 5 7.0 6.2 2 8.3 0.1 2.9 2 1 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2120) Tetradecapep PF08187.6 ERZ97944.1 - 9.3 6.3 9.4 1.5e+02 2.5 0.0 5.5 7 0 0 7 7 7 0 Myoactive tetradecapeptides family DegV PF02645.11 ERZ97947.1 - 0.053 12.5 0.0 0.064 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 DUF2231 PF09990.4 ERZ97948.1 - 0.048 14.0 0.2 0.068 13.5 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) 7tm_4 PF13853.1 ERZ97948.1 - 0.1 12.4 3.2 0.15 11.8 2.2 1.3 1 0 0 1 1 1 0 Olfactory receptor DUF983 PF06170.7 ERZ97948.1 - 0.47 10.6 2.2 1.4 9.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF983) RVT_1 PF00078.22 ERZ97949.1 - 2.2e-06 27.2 0.1 2.4e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Herpes_IE1 PF07340.6 ERZ97950.1 - 0.0012 17.3 0.0 0.0016 16.9 0.0 1.1 1 0 0 1 1 1 1 Cytomegalovirus IE1 protein Herpes_IE1 PF07340.6 ERZ97951.1 - 0.11 10.8 0.0 0.12 10.7 0.0 1.0 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein RVT_1 PF00078.22 ERZ97952.1 - 5.9e-05 22.5 0.1 0.00031 20.1 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF693 PF05113.8 ERZ97952.1 - 0.0052 15.7 0.3 0.0091 14.9 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF693) ApoL PF05461.6 ERZ97952.1 - 0.031 13.5 0.2 0.043 13.0 0.1 1.2 1 0 0 1 1 1 0 Apolipoprotein L PID PF00640.18 ERZ97952.1 - 0.088 12.7 0.8 0.2 11.6 0.6 1.6 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) RVT_1 PF00078.22 ERZ97953.1 - 9.4e-06 25.1 0.1 2e-05 24.0 0.0 1.7 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Profilin PF00235.14 ERZ97953.1 - 0.0035 17.4 0.2 0.13 12.3 0.0 2.1 2 0 0 2 2 2 1 Profilin DUF693 PF05113.8 ERZ97953.1 - 0.0055 15.6 0.4 0.01 14.7 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF693) DDE_1 PF03184.14 ERZ97955.1 - 3.5e-45 153.7 0.7 4.3e-45 153.5 0.5 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ERZ97955.1 - 9.9e-09 35.0 0.1 1.5e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease ABC2_membrane PF01061.19 ERZ97956.1 - 2.9e-21 75.6 11.9 4.5e-21 74.9 8.3 1.3 1 0 0 1 1 1 1 ABC-2 type transporter LRR_4 PF12799.2 ERZ97957.1 - 4.6e-05 22.9 13.5 0.00013 21.5 2.4 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ97957.1 - 0.18 11.9 0.3 0.18 11.9 0.2 3.2 3 0 0 3 3 3 0 Leucine Rich repeat LRR_7 PF13504.1 ERZ97957.1 - 0.33 11.3 5.4 11 6.7 0.0 4.0 3 1 0 3 3 3 0 Leucine rich repeat LRR_8 PF13855.1 ERZ97957.1 - 1.1 9.1 7.5 4.6 7.0 3.3 2.4 1 1 0 1 1 1 0 Leucine rich repeat UXS1_N PF11803.3 ERZ97958.1 - 0.0028 17.3 1.5 0.73 9.6 0.1 3.2 3 0 0 3 3 3 1 UDP-glucuronate decarboxylase N-terminal Lzipper-MIP1 PF14389.1 ERZ97958.1 - 0.007 16.4 11.8 0.007 16.4 8.2 2.7 3 0 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Striatin PF08232.7 ERZ97958.1 - 0.3 11.4 20.6 0.24 11.6 11.9 2.1 2 0 0 2 2 2 0 Striatin family COMP PF11598.3 ERZ97958.1 - 0.31 11.1 0.2 0.31 11.1 0.1 2.7 3 1 0 3 3 3 0 Cartilage oligomeric matrix protein Co_AT_N PF12557.3 ERZ97958.1 - 0.62 10.0 6.4 0.16 11.8 0.6 2.5 2 0 0 2 2 2 0 Cob(I)alamin adenosyltransferase N terminal DUF4519 PF15012.1 ERZ97958.1 - 1 9.3 5.8 4.4 7.3 4.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) CAP18_C PF12153.3 ERZ97958.1 - 2.8 7.6 7.4 0.64 9.7 1.7 2.3 2 0 0 2 2 2 0 LPS binding domain of CAP18 (C terminal) ABC2_membrane PF01061.19 ERZ97959.1 - 4.7e-27 94.5 22.7 6.9e-27 93.9 15.7 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ERZ97959.1 - 2.1e-26 92.8 0.0 4.6e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.2 ERZ97959.1 - 1.1e-09 37.7 8.8 1.8e-09 37.1 6.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.1 ERZ97959.1 - 1.8e-06 28.1 2.6 8.1e-05 22.7 0.6 2.7 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.10 ERZ97959.1 - 4.2e-06 25.7 0.0 4.2e-06 25.7 0.0 2.1 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ERZ97959.1 - 0.00035 20.5 0.1 0.00078 19.4 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ERZ97959.1 - 0.0004 21.2 0.0 0.00079 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 ERZ97959.1 - 0.0016 17.6 2.1 0.037 13.0 0.0 2.5 3 0 0 3 3 3 1 AAA ATPase domain DUF258 PF03193.11 ERZ97959.1 - 0.0021 17.2 0.0 0.0036 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 ERZ97959.1 - 0.0036 16.7 0.0 0.02 14.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ERZ97959.1 - 0.0039 17.3 0.3 0.032 14.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain ABC2_membrane_2 PF12679.2 ERZ97959.1 - 0.0043 15.9 4.4 0.0076 15.1 3.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein Arch_ATPase PF01637.13 ERZ97959.1 - 0.0073 16.0 0.0 0.014 15.0 0.0 1.6 1 1 0 1 1 1 1 Archaeal ATPase RNA_helicase PF00910.17 ERZ97959.1 - 0.011 15.8 0.0 0.1 12.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 ERZ97959.1 - 0.021 14.6 0.0 0.055 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ERZ97959.1 - 0.024 14.5 0.3 0.053 13.4 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ERZ97959.1 - 0.037 14.3 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ERZ97959.1 - 0.042 13.2 0.1 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain PRK PF00485.13 ERZ97959.1 - 0.049 13.1 0.1 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_19 PF13245.1 ERZ97959.1 - 0.072 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ERZ97959.1 - 0.11 12.7 4.9 0.22 11.7 0.4 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 ERZ97959.1 - 0.13 11.9 1.1 1.1 8.8 0.2 2.2 2 0 0 2 2 2 0 NTPase ABC_tran PF00005.22 ERZ97960.1 - 1.4e-20 74.0 0.0 1.9e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ERZ97960.1 - 1.7e-06 28.1 0.6 1.6e-05 25.0 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 ERZ97960.1 - 7.7e-05 21.9 0.1 0.0016 17.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Phosducin PF02114.11 ERZ97962.1 - 1.1e-16 60.3 1.3 1.4e-16 60.0 0.9 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.15 ERZ97962.1 - 0.0062 16.1 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin DUF2346 PF09803.4 ERZ97962.1 - 3.7 7.4 5.3 1.6 8.6 1.1 2.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2346) XPA_C PF05181.7 ERZ97963.1 - 3.7e-29 100.0 0.9 7.5e-29 99.0 0.6 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.13 ERZ97963.1 - 1.8e-05 24.3 2.7 2.7e-05 23.7 1.9 1.3 1 0 0 1 1 1 1 XPA protein N-terminal CLTH PF10607.4 ERZ97964.1 - 8.2e-24 83.9 0.1 1.4e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 ERZ97964.1 - 6.8e-05 22.4 0.0 0.00049 19.7 0.0 2.3 2 0 0 2 2 2 1 LisH NOD PF06816.8 ERZ97967.1 - 0.089 11.8 0.0 0.18 10.8 0.0 1.6 1 0 0 1 1 1 0 NOTCH protein NOD PF06816.8 ERZ97968.1 - 0.062 12.3 0.1 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 NOTCH protein Pkinase_Tyr PF07714.12 ERZ97969.1 - 7.3e-28 97.3 0.0 8e-28 97.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97969.1 - 3.5e-27 95.1 0.0 3.9e-27 95.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ97969.1 - 0.00072 18.6 0.1 0.00079 18.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ97969.1 - 0.011 15.1 0.0 0.012 14.9 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ERZ97969.1 - 0.02 13.8 0.0 0.021 13.8 0.0 1.0 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ERZ97969.1 - 0.024 14.3 0.2 0.027 14.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ERZ97969.1 - 0.03 13.5 0.0 0.034 13.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ERZ97970.1 - 8.8e-57 188.2 15.0 1.9e-11 44.2 1.4 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ97970.1 - 0.0031 17.8 7.3 27 5.5 0.2 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ97970.1 - 0.0061 16.2 3.0 0.47 10.3 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4511 PF14974.1 ERZ97972.1 - 0.005 16.5 0.0 0.045 13.4 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4511) SAM_1 PF00536.25 ERZ97972.1 - 0.016 15.3 0.0 0.044 13.9 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) LEM PF03020.10 ERZ97972.1 - 0.017 14.5 0.0 4.2 6.8 0.0 2.7 2 0 0 2 2 2 0 LEM domain ROS_MUCR PF05443.6 ERZ97972.1 - 0.019 14.7 0.2 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein TLD PF07534.11 ERZ97973.1 - 4.2e-09 36.5 3.1 5.7e-09 36.0 0.5 2.0 1 1 1 2 2 2 1 TLD SAM_1 PF00536.25 ERZ97974.1 - 0.018 15.2 0.0 0.048 13.8 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TBPIP PF07106.8 ERZ97974.1 - 0.038 13.5 0.3 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Dimer_Tnp_hAT PF05699.9 ERZ97976.1 - 1.1e-20 72.9 0.4 1.2e-20 72.8 0.3 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase PF00069.20 ERZ97977.1 - 4.6e-25 88.2 0.1 6e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ97977.1 - 2.5e-23 82.4 0.0 4.5e-22 78.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Dimer_Tnp_hAT PF05699.9 ERZ97978.1 - 1.9e-05 24.2 0.1 4.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TFIIA PF03153.8 ERZ97978.1 - 0.048 13.5 16.4 0.071 12.9 11.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.9 ERZ97978.1 - 0.23 9.4 12.1 0.32 8.9 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.7 ERZ97978.1 - 0.51 9.4 14.4 0.65 9.0 10.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BUD22 PF09073.5 ERZ97978.1 - 0.87 8.5 10.7 1.3 8.0 7.4 1.3 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.7 ERZ97978.1 - 1.6 7.9 17.6 2.5 7.2 12.2 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 ERZ97978.1 - 4.1 5.2 21.3 5.9 4.6 14.8 1.2 1 0 0 1 1 1 0 Nop14-like family Nop25 PF09805.4 ERZ97978.1 - 4.8 7.2 7.5 8.8 6.4 5.2 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Daxx PF03344.10 ERZ97978.1 - 5.1 5.4 13.9 7.2 4.9 9.6 1.2 1 0 0 1 1 1 0 Daxx Family FliJ PF02050.11 ERZ97979.1 - 0.043 13.8 1.1 0.043 13.8 0.7 1.8 2 0 0 2 2 2 0 Flagellar FliJ protein Atg14 PF10186.4 ERZ97981.1 - 0.0037 16.2 0.3 0.0039 16.1 0.2 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 DUF4201 PF13870.1 ERZ97981.1 - 0.27 10.6 4.4 0.63 9.4 3.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) I_LWEQ PF01608.12 ERZ97981.1 - 2.3 8.1 5.7 4 7.3 4.0 1.4 1 1 0 1 1 1 0 I/LWEQ domain Helitron_like_N PF14214.1 ERZ97982.1 - 9.8e-08 31.9 0.3 1.3e-07 31.5 0.2 1.2 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Sif PF06767.6 ERZ97982.1 - 0.11 11.2 0.4 0.11 11.2 0.3 1.1 1 0 0 1 1 1 0 Sif protein Helitron_like_N PF14214.1 ERZ97983.1 - 4.8e-15 55.7 0.0 5.4e-15 55.6 0.0 1.0 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Bcl-2 PF00452.14 ERZ97983.1 - 0.091 12.8 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Endonuc-MspI PF09208.5 ERZ97983.1 - 0.14 11.2 0.6 0.16 10.9 0.4 1.0 1 0 0 1 1 1 0 Restriction endonuclease MspI Pkinase_Tyr PF07714.12 ERZ97985.1 - 1.1e-37 129.4 0.0 1.6e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ97985.1 - 3.8e-31 108.1 0.5 8.7e-31 107.0 0.4 1.6 1 1 0 1 1 1 1 Protein kinase domain AAA_5 PF07728.9 ERZ97987.1 - 5.7e-86 285.2 0.0 6.6e-37 126.3 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ERZ97987.1 - 1.4e-07 31.7 0.1 0.16 11.9 0.0 4.0 3 1 1 4 4 4 2 AAA ATPase domain VWA_2 PF13519.1 ERZ97987.1 - 5.9e-05 23.2 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_3 PF07726.6 ERZ97987.1 - 0.00054 19.5 0.0 0.31 10.6 0.0 3.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ97987.1 - 0.00079 19.5 0.1 4.2 7.5 0.0 3.9 3 1 0 3 3 3 2 AAA domain AAA PF00004.24 ERZ97987.1 - 0.0018 18.4 0.0 1.2 9.3 0.0 3.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 ERZ97987.1 - 0.026 13.6 0.0 6.9 5.7 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Miro PF08477.8 ERZ97987.1 - 0.099 13.1 0.0 1.6 9.2 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein DUF258 PF03193.11 ERZ97987.1 - 0.15 11.2 0.0 14 4.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_28 PF13521.1 ERZ97987.1 - 0.16 11.9 0.0 0.49 10.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pinin_SDK_memA PF04696.8 ERZ97988.1 - 1.8e-23 82.5 18.1 1.8e-23 82.5 12.5 2.5 2 1 1 3 3 3 1 pinin/SDK/memA/ protein conserved region CAF-1_p150 PF11600.3 ERZ97988.1 - 0.37 10.1 40.6 0.0084 15.5 17.2 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SprA-related PF12118.3 ERZ97988.1 - 3.9 6.7 32.9 0.23 10.7 9.1 2.1 2 0 0 2 2 2 0 SprA-related family Aldedh PF00171.17 ERZ97990.1 - 8.8e-20 70.4 0.3 8.6e-14 50.7 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF3568 PF12092.3 ERZ97991.1 - 0.092 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) AAA PF00004.24 ERZ97992.1 - 1.2e-59 200.1 0.0 8.8e-44 148.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 ERZ97992.1 - 7.6e-18 64.3 0.3 2.9e-17 62.4 0.2 2.1 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal PEX-2N PF09263.5 ERZ97992.1 - 6.8e-08 32.7 0.0 2.3e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 ERZ97992.1 - 6.3e-07 29.5 10.6 0.051 13.5 0.1 4.7 3 2 1 4 4 3 2 AAA ATPase domain RuvB_N PF05496.7 ERZ97992.1 - 2.4e-06 26.7 0.0 0.0032 16.5 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ERZ97992.1 - 5.1e-06 27.3 0.0 0.014 16.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 ERZ97992.1 - 1.9e-05 24.5 0.0 0.055 13.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ERZ97992.1 - 1.9e-05 24.4 0.0 0.23 11.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ERZ97992.1 - 2.6e-05 24.3 3.4 0.15 12.1 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_2 PF07724.9 ERZ97992.1 - 4.6e-05 23.4 0.0 0.037 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 ERZ97992.1 - 5.9e-05 23.1 0.0 0.31 11.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.7 ERZ97992.1 - 6e-05 22.7 0.2 0.1 12.2 0.0 3.4 3 0 0 3 3 3 1 NACHT domain TIP49 PF06068.8 ERZ97992.1 - 9.1e-05 21.3 0.0 0.26 9.9 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_33 PF13671.1 ERZ97992.1 - 9.5e-05 22.3 0.0 0.063 13.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ERZ97992.1 - 0.00023 21.4 0.0 0.8 10.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 ERZ97992.1 - 0.00026 20.2 0.3 0.81 8.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 ERZ97992.1 - 0.00051 19.5 0.3 0.72 9.2 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 ERZ97992.1 - 0.00056 19.0 0.1 0.51 9.4 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_19 PF13245.1 ERZ97992.1 - 0.00096 18.8 0.0 1.9 8.3 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain Sigma54_activ_2 PF14532.1 ERZ97992.1 - 0.00097 19.1 0.0 1.3 9.0 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.8 ERZ97992.1 - 0.0012 17.7 0.0 0.11 11.3 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) SKI PF01202.17 ERZ97992.1 - 0.011 15.6 0.0 0.41 10.5 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase AAA_25 PF13481.1 ERZ97992.1 - 0.011 15.1 5.6 16 4.8 0.1 4.2 2 2 1 4 4 4 0 AAA domain Viral_helicase1 PF01443.13 ERZ97992.1 - 0.012 15.0 0.0 0.06 12.8 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 ERZ97992.1 - 0.021 14.4 0.3 3.7 7.2 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 Cytidylate_kin2 PF13189.1 ERZ97992.1 - 0.021 14.7 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_28 PF13521.1 ERZ97992.1 - 0.022 14.6 0.0 6.6 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ERZ97992.1 - 0.04 14.2 0.0 6.1 7.1 0.0 2.8 2 0 0 2 2 2 0 ABC transporter NB-ARC PF00931.17 ERZ97992.1 - 0.05 12.4 0.0 1.6 7.4 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_3 PF07726.6 ERZ97992.1 - 0.09 12.3 0.0 0.86 9.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Tubulin_3 PF14881.1 ERZ97993.1 - 5.3e-47 159.6 0.1 1.1e-46 158.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 ERZ97993.1 - 2.1e-38 130.9 0.1 4.8e-38 129.7 0.1 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 ERZ97993.1 - 1.2e-10 41.5 0.0 1.7e-09 37.8 0.0 2.4 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain WD40 PF00400.27 ERZ97995.1 - 6.5e-20 70.2 3.9 1.9e-05 24.3 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat eIF2A PF08662.6 ERZ97995.1 - 0.00033 20.4 2.0 0.43 10.2 0.1 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A MF_alpha_N PF05436.6 ERZ97996.1 - 0.0094 15.6 0.1 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus Imm23 PF15593.1 ERZ97997.1 - 0.00084 19.6 1.1 0.0019 18.4 0.7 1.5 1 0 0 1 1 1 1 Immunity protein 23 Ery_res_leader2 PF08057.6 ERZ97997.1 - 0.028 14.4 0.3 0.063 13.3 0.2 1.6 1 0 0 1 1 1 0 Erythromycin resistance leader peptide UBN_AB PF14075.1 ERZ97999.1 - 0.026 14.2 0.8 0.026 14.2 0.5 1.9 1 1 1 2 2 2 0 Ubinuclein conserved middle domain DUF1041 PF06292.12 ERZ97999.1 - 0.11 12.7 0.8 0.18 11.9 0.3 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) Ribosomal_L30_N PF08079.7 ERZ97999.1 - 0.77 9.8 5.3 2.6 8.1 3.7 1.9 1 1 0 1 1 1 0 Ribosomal L30 N-terminal domain Colicin_D PF11429.3 ERZ98000.1 - 3.7e-13 49.4 0.4 4.6e-13 49.1 0.3 1.1 1 0 0 1 1 1 1 Colicin D DivIC PF04977.10 ERZ98001.1 - 0.00067 19.1 3.2 0.00067 19.1 2.2 3.2 1 1 2 3 3 3 2 Septum formation initiator bZIP_1 PF00170.16 ERZ98001.1 - 0.0007 19.5 13.3 0.0082 16.0 5.1 2.8 2 1 0 2 2 2 1 bZIP transcription factor HALZ PF02183.13 ERZ98001.1 - 0.0012 18.4 3.6 0.0031 17.1 0.5 2.6 2 1 0 2 2 2 1 Homeobox associated leucine zipper Lebercilin PF15619.1 ERZ98001.1 - 0.0024 17.3 7.6 0.37 10.1 0.0 2.6 1 1 0 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease TMF_TATA_bd PF12325.3 ERZ98001.1 - 0.0055 16.4 13.6 0.032 13.9 5.5 2.5 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 ERZ98001.1 - 0.029 14.1 14.4 0.089 12.6 4.2 2.6 2 0 0 2 2 2 0 Basic region leucine zipper Atg14 PF10186.4 ERZ98001.1 - 0.058 12.3 9.0 0.069 12.0 6.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3186 PF11382.3 ERZ98001.1 - 0.059 12.4 1.9 1.8 7.6 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3186) DivIVA PF05103.8 ERZ98001.1 - 0.075 13.0 11.4 0.098 12.7 7.4 1.6 1 1 0 1 1 1 0 DivIVA protein Glyco_hydro_108 PF05838.7 ERZ98001.1 - 0.08 13.0 0.6 0.2 11.8 0.4 1.8 1 1 0 1 1 1 0 Glycosyl hydrolase 108 DUF904 PF06005.7 ERZ98001.1 - 0.091 13.0 15.3 2.6 8.4 5.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF972 PF06156.8 ERZ98001.1 - 0.11 12.8 11.8 0.13 12.5 4.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Kinesin-relat_1 PF12711.2 ERZ98001.1 - 0.15 12.4 7.6 0.18 12.1 2.4 2.3 1 1 1 2 2 2 0 Kinesin motor MscS_porin PF12795.2 ERZ98001.1 - 0.15 11.3 19.6 1.1 8.5 13.6 1.9 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Seryl_tRNA_N PF02403.17 ERZ98001.1 - 0.21 11.5 14.4 2 8.4 6.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CtIP_N PF10482.4 ERZ98001.1 - 0.23 11.2 9.4 0.56 10.0 1.6 2.5 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain IncA PF04156.9 ERZ98001.1 - 0.23 11.0 21.5 0.49 9.9 14.9 1.5 1 1 0 1 1 1 0 IncA protein FtsL PF04999.8 ERZ98001.1 - 0.24 11.1 3.1 0.5 10.1 2.2 1.6 1 0 0 1 1 1 0 Cell division protein FtsL DUF4140 PF13600.1 ERZ98001.1 - 0.26 11.7 9.0 0.096 13.1 1.6 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4239 PF14023.1 ERZ98001.1 - 0.4 10.0 4.4 0.13 11.6 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) TSC22 PF01166.13 ERZ98001.1 - 0.63 10.0 5.3 12 5.9 1.7 3.0 2 1 0 2 2 2 0 TSC-22/dip/bun family V_ATPase_I PF01496.14 ERZ98001.1 - 1 7.1 7.9 1.2 6.8 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Filament PF00038.16 ERZ98001.1 - 1 8.7 16.5 1.7 8.0 6.5 2.0 1 1 1 2 2 2 0 Intermediate filament protein CASP_C PF08172.7 ERZ98001.1 - 1.1 8.1 11.7 14 4.5 8.0 2.1 1 1 0 1 1 1 0 CASP C terminal DUF4048 PF13257.1 ERZ98001.1 - 3.3 7.2 8.7 0.62 9.6 3.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4048) DUF2205 PF10224.4 ERZ98001.1 - 3.3 7.3 10.3 0.31 10.6 3.1 2.2 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Cep57_CLD_2 PF14197.1 ERZ98001.1 - 3.5 7.6 10.4 6.4 6.7 4.1 2.6 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 RNase_H PF00075.19 ERZ98004.1 - 0.11 12.8 0.3 9.9 6.5 0.0 2.5 2 0 0 2 2 2 0 RNase H TEBP_beta PF07404.6 ERZ98006.1 - 0.13 11.4 0.8 0.18 10.8 0.6 1.1 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Ion_trans PF00520.26 ERZ98007.1 - 0.014 14.6 19.4 0.021 14.0 13.4 1.3 1 0 0 1 1 1 0 Ion transport protein DUF547 PF04784.9 ERZ98008.1 - 0.02 14.7 0.2 0.024 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF547 Myb_DNA-bind_3 PF12776.2 ERZ98008.1 - 0.026 15.1 0.5 0.84 10.3 0.1 2.0 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DNA_pol_B PF00136.16 ERZ98009.1 - 4.4e-69 233.4 4.2 4.3e-68 230.2 2.7 2.0 1 1 0 1 1 1 1 DNA polymerase family B MMR_HSR1 PF01926.18 ERZ98011.1 - 9.2e-10 38.4 0.1 3.2e-09 36.7 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 ERZ98011.1 - 6.8e-06 25.3 0.1 0.042 12.9 0.0 2.6 2 0 0 2 2 2 2 AIG1 family Septin PF00735.13 ERZ98011.1 - 1.3e-05 24.3 0.9 8.9e-05 21.6 0.7 2.3 1 1 0 1 1 1 1 Septin Dynamin_N PF00350.18 ERZ98011.1 - 9.5e-05 22.2 5.6 0.004 17.0 0.7 3.4 2 2 0 2 2 2 1 Dynamin family DUF258 PF03193.11 ERZ98011.1 - 0.00012 21.3 0.0 0.00043 19.5 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ERZ98011.1 - 0.00034 20.0 0.1 0.0014 18.1 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ERZ98011.1 - 0.00066 19.1 0.2 0.0027 17.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SMC_N PF02463.14 ERZ98011.1 - 0.0072 15.5 1.0 0.05 12.8 0.0 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.13 ERZ98011.1 - 0.0097 15.4 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.1 ERZ98011.1 - 0.011 15.7 0.0 0.051 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Prefoldin_3 PF13758.1 ERZ98011.1 - 0.02 14.6 1.0 0.056 13.2 0.7 1.7 1 0 0 1 1 1 0 Prefoldin subunit T2SE PF00437.15 ERZ98011.1 - 0.022 13.6 0.0 0.041 12.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.17 ERZ98011.1 - 0.028 14.6 0.1 0.12 12.6 0.0 2.2 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.22 ERZ98011.1 - 0.048 13.9 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Miro PF08477.8 ERZ98011.1 - 0.05 14.1 0.1 0.31 11.5 0.0 2.5 2 0 0 2 2 1 0 Miro-like protein NACHT PF05729.7 ERZ98011.1 - 0.06 12.9 0.0 0.92 9.1 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 ERZ98011.1 - 0.062 13.5 0.6 1.8 8.7 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 ERZ98011.1 - 0.068 12.8 0.0 0.21 11.2 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.21 ERZ98011.1 - 0.088 12.2 0.0 0.36 10.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.1 ERZ98011.1 - 0.089 12.9 0.0 0.39 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF2652 PF10851.3 ERZ98012.1 - 0.011 15.6 0.1 0.027 14.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2652) HALZ PF02183.13 ERZ98013.1 - 6.2e-07 29.0 4.3 3.4e-06 26.6 1.0 2.3 2 0 0 2 2 2 1 Homeobox associated leucine zipper DivIC PF04977.10 ERZ98013.1 - 8.5e-06 25.1 9.2 0.0018 17.7 1.1 2.4 2 0 0 2 2 2 2 Septum formation initiator bZIP_1 PF00170.16 ERZ98013.1 - 0.00077 19.3 5.3 0.035 14.0 0.5 2.2 2 0 0 2 2 2 2 bZIP transcription factor DUF904 PF06005.7 ERZ98013.1 - 0.00095 19.4 13.8 0.063 13.5 3.4 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF904) TBPIP PF07106.8 ERZ98013.1 - 0.011 15.3 8.5 0.018 14.5 5.9 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_TATA_bd PF12325.3 ERZ98013.1 - 0.013 15.2 9.6 0.13 12.0 6.7 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.1 ERZ98013.1 - 0.013 15.4 8.0 0.09 12.7 1.8 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF3527 PF12043.3 ERZ98013.1 - 0.013 15.0 1.4 0.017 14.6 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) bZIP_2 PF07716.10 ERZ98013.1 - 0.016 15.0 10.6 0.19 11.5 1.7 2.4 2 0 0 2 2 2 0 Basic region leucine zipper IncA PF04156.9 ERZ98013.1 - 0.017 14.7 9.1 0.024 14.2 6.3 1.1 1 0 0 1 1 1 0 IncA protein DUF1853 PF08907.6 ERZ98013.1 - 0.02 14.0 0.4 0.023 13.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1853) Seryl_tRNA_N PF02403.17 ERZ98013.1 - 0.03 14.3 7.5 2.3 8.2 3.2 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CCDC92 PF14916.1 ERZ98013.1 - 0.031 13.8 2.3 0.29 10.7 0.0 2.5 2 0 0 2 2 2 0 Coiled-coil domain of unknown function Lebercilin PF15619.1 ERZ98013.1 - 0.049 13.0 5.6 0.63 9.4 3.9 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Rab5-bind PF09311.6 ERZ98013.1 - 0.072 12.9 9.9 0.11 12.3 2.9 2.0 1 1 1 2 2 2 0 Rabaptin-like protein DUF3186 PF11382.3 ERZ98013.1 - 0.085 11.9 3.8 1.1 8.3 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3186) CtIP_N PF10482.4 ERZ98013.1 - 0.086 12.6 7.4 1.9 8.3 0.8 2.3 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain ERM PF00769.14 ERZ98013.1 - 0.12 11.8 7.4 0.19 11.2 5.2 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family MscS_porin PF12795.2 ERZ98013.1 - 0.13 11.5 10.8 0.19 11.0 7.5 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TSC22 PF01166.13 ERZ98013.1 - 0.21 11.5 6.3 2.3 8.2 1.2 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family DivIVA PF05103.8 ERZ98013.1 - 0.25 11.3 10.6 1.9 8.5 7.4 2.0 1 1 0 1 1 1 0 DivIVA protein DUF972 PF06156.8 ERZ98013.1 - 0.39 11.0 9.8 0.72 10.2 2.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 ERZ98013.1 - 0.69 9.7 8.5 3.2 7.6 0.4 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2681 PF10883.3 ERZ98013.1 - 0.78 9.9 10.1 0.56 10.4 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Kinesin-relat_1 PF12711.2 ERZ98013.1 - 1.3 9.4 7.0 36 4.8 4.9 2.4 1 1 0 1 1 1 0 Kinesin motor ADIP PF11559.3 ERZ98013.1 - 3.3 7.6 16.0 0.021 14.7 5.4 1.6 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding CASP_C PF08172.7 ERZ98013.1 - 3.4 6.6 7.9 2.3 7.1 0.8 2.0 1 1 1 2 2 2 0 CASP C terminal GrpE PF01025.14 ERZ98013.1 - 9 5.8 9.4 1.2e+02 2.2 6.5 2.3 1 1 0 1 1 1 0 GrpE DUF4528 PF15031.1 ERZ98015.1 - 0.081 12.6 0.1 0.16 11.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4528) Pkinase PF00069.20 ERZ98017.1 - 9.8e-65 218.2 0.0 1.2e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98017.1 - 4.3e-32 111.2 0.0 6.1e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98017.1 - 6.1e-05 22.1 0.0 0.00012 21.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ98017.1 - 0.042 13.5 0.1 0.076 12.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kelch_4 PF13418.1 ERZ98018.1 - 4e-12 45.7 0.7 0.0057 16.3 0.0 5.1 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ98018.1 - 1e-10 41.3 1.3 0.037 14.1 0.0 4.4 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ERZ98018.1 - 7.1e-07 28.6 7.9 0.093 12.2 0.1 5.0 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 ERZ98018.1 - 2.6e-06 27.2 0.1 0.6 10.1 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ERZ98018.1 - 2.6e-05 23.8 2.6 0.45 10.3 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ERZ98018.1 - 3.1e-05 24.0 4.6 2.6 8.3 0.9 5.5 4 2 0 4 4 4 2 Galactose oxidase, central domain F-box-like PF12937.2 ERZ98018.1 - 0.023 14.3 0.0 0.074 12.7 0.0 1.9 1 0 0 1 1 1 0 F-box-like PRANC PF09372.5 ERZ98018.1 - 0.042 13.8 0.1 0.042 13.8 0.1 3.2 4 1 0 4 4 4 0 PRANC domain HSP70 PF00012.15 ERZ98020.1 - 3.2e-08 31.9 0.0 1.1e-07 30.1 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ98020.1 - 0.0015 17.2 0.0 0.0072 14.9 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein MreB_Mbl PF06723.8 ERZ98021.1 - 0.0015 17.2 0.0 0.053 12.1 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein BcrAD_BadFG PF01869.15 ERZ98021.1 - 0.027 13.7 0.0 0.052 12.8 0.0 1.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.15 ERZ98022.1 - 0.00045 18.2 0.0 0.0018 16.3 0.0 1.9 1 1 0 1 1 1 1 Hsp70 protein DJ-1_PfpI PF01965.19 ERZ98022.1 - 0.093 12.1 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family MreB_Mbl PF06723.8 ERZ98022.1 - 0.11 11.1 0.0 1.4 7.4 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Pkinase_Tyr PF07714.12 ERZ98023.1 - 3.5e-05 23.0 0.1 4.3e-05 22.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98023.1 - 0.0021 17.2 0.2 0.0027 16.9 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain MTS_N PF08468.6 ERZ98023.1 - 0.072 12.9 0.0 0.099 12.4 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain N-terminal DUF2462 PF09495.5 ERZ98024.1 - 0.063 14.0 0.4 0.34 11.6 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2462) IncA PF04156.9 ERZ98025.1 - 0.0048 16.5 16.0 0.016 14.8 3.3 2.0 1 1 1 2 2 2 2 IncA protein Pox_A_type_inc PF04508.7 ERZ98025.1 - 0.013 15.1 2.4 0.013 15.1 1.7 4.4 4 1 0 4 4 4 0 Viral A-type inclusion protein repeat AAA_13 PF13166.1 ERZ98025.1 - 0.014 13.8 10.0 0.018 13.5 6.9 1.1 1 0 0 1 1 1 0 AAA domain Laminin_I PF06008.9 ERZ98025.1 - 0.02 14.2 6.9 0.014 14.6 3.5 1.7 1 1 0 1 1 1 0 Laminin Domain I APG6 PF04111.7 ERZ98025.1 - 0.023 13.7 7.1 0.03 13.3 4.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Shugoshin_N PF07558.6 ERZ98025.1 - 0.024 14.3 6.8 0.068 12.8 0.1 3.2 3 1 0 3 3 3 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.10 ERZ98025.1 - 0.025 14.0 4.6 0.025 14.0 3.2 3.1 2 1 1 3 3 3 0 Septum formation initiator Atg14 PF10186.4 ERZ98025.1 - 0.028 13.3 9.3 0.037 12.9 6.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ATG16 PF08614.6 ERZ98025.1 - 0.051 13.3 14.1 0.089 12.6 9.6 1.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TSC22 PF01166.13 ERZ98025.1 - 0.062 13.2 0.8 0.062 13.2 0.5 3.1 2 2 1 3 3 3 0 TSC-22/dip/bun family HAUS5 PF14817.1 ERZ98025.1 - 0.063 11.8 6.0 0.08 11.4 4.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 V_ATPase_I PF01496.14 ERZ98025.1 - 0.066 11.0 4.6 0.073 10.9 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2630 PF10944.3 ERZ98025.1 - 0.079 13.0 1.2 0.079 13.0 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2630) Peptidase_S46 PF10459.4 ERZ98025.1 - 0.096 11.0 2.9 0.12 10.7 2.0 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF677 PF05055.7 ERZ98025.1 - 0.12 10.9 6.6 0.061 11.9 2.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF677) Kinesin-related PF06548.6 ERZ98025.1 - 0.13 10.7 11.8 0.27 9.7 0.9 2.6 2 1 1 3 3 3 0 Kinesin-related Reo_sigmaC PF04582.7 ERZ98025.1 - 0.13 11.3 1.9 0.27 10.3 0.9 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein CENP-Q PF13094.1 ERZ98025.1 - 0.14 12.1 10.8 0.23 11.4 7.5 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MAD PF05557.8 ERZ98025.1 - 0.18 9.8 12.7 0.076 11.0 2.4 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Syntaxin PF00804.20 ERZ98025.1 - 0.2 11.8 16.2 0.8 9.8 6.3 2.3 1 1 1 2 2 2 0 Syntaxin FliJ PF02050.11 ERZ98025.1 - 0.22 11.5 8.7 0.29 11.2 4.4 2.0 2 0 0 2 2 2 0 Flagellar FliJ protein ALMT PF11744.3 ERZ98025.1 - 0.29 9.7 2.4 0.34 9.5 1.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SlyX PF04102.7 ERZ98025.1 - 0.32 11.3 7.1 0.51 10.7 1.5 2.7 1 1 1 2 2 2 0 SlyX DUF1640 PF07798.6 ERZ98025.1 - 0.39 10.7 11.2 4.4 7.3 4.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Syntaxin_2 PF14523.1 ERZ98025.1 - 0.42 10.6 14.5 0.45 10.5 6.4 2.5 1 1 1 2 2 2 0 Syntaxin-like protein TBPIP PF07106.8 ERZ98025.1 - 0.58 9.6 14.9 0.19 11.2 3.8 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Rho_Binding PF08912.6 ERZ98025.1 - 0.77 10.0 11.3 1.3 9.3 1.0 2.6 2 1 0 2 2 2 0 Rho Binding CENP-F_leu_zip PF10473.4 ERZ98025.1 - 0.79 9.5 12.4 2 8.2 8.6 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.3 ERZ98025.1 - 0.85 9.3 13.0 2 8.1 6.0 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.5 ERZ98025.1 - 0.9 9.6 12.8 0.45 10.6 5.9 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF2730 PF10805.3 ERZ98025.1 - 1 9.1 5.1 9.5 6.0 1.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FlaC_arch PF05377.6 ERZ98025.1 - 1 9.2 13.1 1.2 9.0 0.8 3.6 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.7 ERZ98025.1 - 1.1 9.0 8.5 1.7e+02 1.9 6.2 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF972 PF06156.8 ERZ98025.1 - 2 8.7 9.7 5 7.5 3.8 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Seryl_tRNA_N PF02403.17 ERZ98025.1 - 2.5 8.1 13.9 0.64 10.0 3.9 2.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain P4Ha_N PF08336.6 ERZ98025.1 - 2.7 7.8 7.3 8 6.2 0.9 3.1 1 1 3 4 4 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF4140 PF13600.1 ERZ98025.1 - 2.8 8.4 9.1 0.8 10.1 0.8 2.9 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) FlxA PF14282.1 ERZ98025.1 - 3.3 7.7 13.1 2.8 7.9 7.6 2.0 1 1 1 2 2 2 0 FlxA-like protein AAA_23 PF13476.1 ERZ98025.1 - 3.4 7.9 12.2 5 7.3 8.4 1.3 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.7 ERZ98025.1 - 3.6 7.3 11.8 3.8 7.2 6.4 1.9 1 1 1 2 2 2 0 Laminin Domain II Rootletin PF15035.1 ERZ98025.1 - 4.9 7.0 11.0 11 5.8 2.7 2.7 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF904 PF06005.7 ERZ98025.1 - 5.1 7.4 19.8 5.3 7.4 2.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF904) DMPK_coil PF08826.5 ERZ98025.1 - 5.4 6.9 10.5 3.9 7.4 1.1 3.1 3 0 0 3 3 3 0 DMPK coiled coil domain like HALZ PF02183.13 ERZ98025.1 - 5.9 6.6 9.6 2.9 7.6 1.0 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper Syntaxin-6_N PF09177.6 ERZ98025.1 - 6.4 7.2 7.9 22 5.5 0.8 2.8 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TMPIT PF07851.8 ERZ98025.1 - 6.9 5.6 7.7 15 4.4 5.3 1.6 1 1 1 2 2 2 0 TMPIT-like protein ORF6C PF10552.4 ERZ98025.1 - 7.7 6.2 11.1 0.57 9.9 1.1 2.6 2 1 1 3 3 2 0 ORF6C domain ING PF12998.2 ERZ98025.1 - 8.6 6.6 11.9 11 6.2 7.5 1.8 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Med9 PF07544.8 ERZ98025.1 - 9.4 6.0 11.2 3.4 7.4 2.7 2.8 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HMGL-like PF00682.14 ERZ98026.1 - 0.0064 16.1 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Pox_A_type_inc PF04508.7 ERZ98026.1 - 0.025 14.3 2.6 0.025 14.3 1.8 4.7 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat APG6 PF04111.7 ERZ98026.1 - 0.034 13.1 15.9 0.17 10.9 2.6 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF677 PF05055.7 ERZ98026.1 - 0.039 12.6 6.8 0.024 13.3 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF677) DUF2630 PF10944.3 ERZ98026.1 - 0.044 13.8 0.4 0.044 13.8 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2630) Med9 PF07544.8 ERZ98026.1 - 0.11 12.3 10.6 0.096 12.4 2.2 3.3 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 WEMBL PF05701.6 ERZ98026.1 - 0.16 10.4 11.0 0.18 10.2 1.0 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light DUF1664 PF07889.7 ERZ98026.1 - 1.2 9.0 6.9 21 4.9 2.6 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 ERZ98026.1 - 1.5 8.9 17.9 0.11 12.5 4.2 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin PF00804.20 ERZ98026.1 - 1.6 8.8 17.3 0.63 10.2 5.3 3.0 1 1 2 3 3 3 0 Syntaxin CENP-F_leu_zip PF10473.4 ERZ98026.1 - 1.8 8.4 17.6 2.4 7.9 0.2 3.2 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.6 ERZ98026.1 - 1.9 8.4 12.6 6 6.8 0.5 4.1 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) IncA PF04156.9 ERZ98026.1 - 2.2 7.8 23.8 1.1 8.8 7.8 2.7 2 1 0 2 2 2 0 IncA protein RAP1 PF07218.6 ERZ98028.1 - 2.6 6.0 18.5 3.1 5.7 12.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4614 PF15391.1 ERZ98028.1 - 2.8 7.6 14.4 4.2 7.0 10.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DUF1212 PF06738.7 ERZ98029.1 - 0.0011 18.4 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1212) F-box-like PF12937.2 ERZ98029.1 - 0.0029 17.2 0.4 0.0066 16.1 0.1 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ98029.1 - 0.02 14.5 1.2 0.079 12.6 0.3 2.3 2 1 0 2 2 2 0 F-box domain PRANC PF09372.5 ERZ98029.1 - 0.037 13.9 0.6 0.037 13.9 0.4 1.8 1 1 0 1 1 1 0 PRANC domain Retrotrans_gag PF03732.12 ERZ98029.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.6 1 1 1 2 2 2 0 Retrotransposon gag protein bZIP_1 PF00170.16 ERZ98030.1 - 0.00024 20.9 8.9 0.028 14.3 3.4 3.0 2 1 0 2 2 2 2 bZIP transcription factor DivIC PF04977.10 ERZ98030.1 - 0.0063 15.9 2.0 0.0063 15.9 1.4 3.3 2 1 1 3 3 3 2 Septum formation initiator DUF2205 PF10224.4 ERZ98030.1 - 0.021 14.4 2.0 0.021 14.4 1.4 2.1 2 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Atg14 PF10186.4 ERZ98030.1 - 0.059 12.2 8.5 0.068 12.0 5.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HALZ PF02183.13 ERZ98030.1 - 0.11 12.1 2.7 0.15 11.7 0.2 2.5 2 1 0 2 2 2 0 Homeobox associated leucine zipper TMF_TATA_bd PF12325.3 ERZ98030.1 - 0.12 12.1 12.5 0.23 11.2 5.0 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 ERZ98030.1 - 0.18 11.6 12.0 1.7 8.5 3.7 3.3 2 1 0 2 2 2 0 Basic region leucine zipper DUF904 PF06005.7 ERZ98030.1 - 0.19 12.0 13.1 3.8 7.8 6.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF4239 PF14023.1 ERZ98030.1 - 0.31 10.3 2.8 0.19 11.1 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) Glyco_hydro_108 PF05838.7 ERZ98030.1 - 1.2 9.2 4.0 0.43 10.7 0.3 2.2 2 1 0 2 2 2 0 Glycosyl hydrolase 108 TSC22 PF01166.13 ERZ98030.1 - 1.4 8.9 6.7 19 5.2 1.7 3.1 1 1 2 3 3 3 0 TSC-22/dip/bun family DUF972 PF06156.8 ERZ98030.1 - 2.5 8.4 11.3 1.3 9.4 4.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Seryl_tRNA_N PF02403.17 ERZ98030.1 - 5.7 7.0 13.2 4.1 7.4 5.2 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.1 ERZ98030.1 - 5.7 7.4 10.5 0.2 12.1 1.6 2.3 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Tropomyosin_1 PF12718.2 ERZ98030.1 - 6.2 6.6 16.2 60 3.4 11.2 2.1 1 1 0 1 1 1 0 Tropomyosin like KLRAQ PF10205.4 ERZ98030.1 - 8.2 6.5 12.8 7.1 6.7 7.3 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein TPT PF03151.11 ERZ98033.1 - 1.6e-15 57.0 11.0 1.6e-15 57.0 7.6 2.0 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 ERZ98033.1 - 2.3e-08 33.3 17.8 4.4e-08 32.3 12.3 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 ERZ98033.1 - 2.2e-05 24.4 24.5 0.014 15.4 2.5 2.1 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 ERZ98033.1 - 0.0046 17.1 17.7 0.3 11.2 1.3 2.4 2 0 0 2 2 2 2 Multidrug resistance efflux transporter GATA PF00320.22 ERZ98034.1 - 0.0012 18.0 4.6 0.0024 17.2 3.2 1.5 1 0 0 1 1 1 1 GATA zinc finger PLDc PF00614.17 ERZ98035.1 - 2.2e-15 55.8 1.3 1e-08 34.6 0.2 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 ERZ98035.1 - 2.8e-13 49.7 2.6 4.6e-07 29.6 0.4 3.4 3 1 0 3 3 3 2 PLD-like domain Methyltransf_11 PF08241.7 ERZ98037.1 - 3e-12 46.8 0.0 5.7e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ98037.1 - 4.4e-12 46.0 0.0 6.5e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ98037.1 - 1.2e-10 41.1 0.1 1e-09 38.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ98037.1 - 2.3e-08 34.3 0.0 5.7e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ98037.1 - 3.3e-08 32.8 0.0 5.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ERZ98037.1 - 2.4e-07 31.3 0.0 7.2e-07 29.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ98037.1 - 8.4e-06 26.0 0.0 1.9e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ98037.1 - 7.4e-05 21.9 0.0 0.00017 20.7 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 ERZ98037.1 - 0.002 17.5 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ERZ98037.1 - 0.0024 17.8 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ERZ98037.1 - 0.0024 16.9 0.3 0.0094 15.0 0.2 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 ERZ98037.1 - 0.0054 16.7 0.1 0.017 15.1 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_9 PF08003.6 ERZ98037.1 - 0.0081 14.8 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.7 ERZ98037.1 - 0.042 13.2 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CRT-like PF08627.5 ERZ98038.1 - 4.8 7.1 8.2 3.2 7.7 1.2 2.3 2 0 0 2 2 2 0 CRT-like SAM_1 PF00536.25 ERZ98039.1 - 0.00091 19.3 0.0 0.024 14.8 0.0 2.4 1 1 1 2 2 2 1 SAM domain (Sterile alpha motif) AAA_22 PF13401.1 ERZ98039.1 - 0.08 13.0 0.1 5.6 7.1 0.0 2.8 2 1 1 3 3 3 0 AAA domain HORMA PF02301.13 ERZ98040.1 - 0.058 12.8 0.1 0.058 12.8 0.1 1.1 1 0 0 1 1 1 0 HORMA domain CCDC14 PF15254.1 ERZ98041.1 - 0.0001 20.9 2.0 0.00012 20.6 1.4 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 14 Pox_A_type_inc PF04508.7 ERZ98041.1 - 0.00087 18.8 12.6 0.0046 16.6 1.6 3.3 3 0 0 3 3 3 1 Viral A-type inclusion protein repeat DUF677 PF05055.7 ERZ98041.1 - 0.0011 17.7 4.7 0.0012 17.5 3.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF677) Med9 PF07544.8 ERZ98041.1 - 0.0026 17.4 3.2 0.0026 17.4 2.2 1.6 2 0 0 2 2 1 1 RNA polymerase II transcription mediator complex subunit 9 ATG16 PF08614.6 ERZ98041.1 - 0.0036 17.1 5.9 0.0047 16.7 4.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DivIC PF04977.10 ERZ98041.1 - 0.0084 15.5 4.0 0.0084 15.5 2.8 2.2 1 1 1 2 2 2 1 Septum formation initiator Fib_alpha PF08702.5 ERZ98041.1 - 0.0095 16.0 6.7 0.0095 16.0 4.6 1.5 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF2630 PF10944.3 ERZ98041.1 - 0.0096 16.0 4.7 0.021 14.9 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2630) Ead_Ea22 PF13935.1 ERZ98041.1 - 0.01 16.1 1.0 0.012 15.9 0.7 1.1 1 0 0 1 1 1 0 Ead/Ea22-like protein CCDC155 PF14662.1 ERZ98041.1 - 0.018 14.6 1.9 0.018 14.6 1.3 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Effector_1 PF04518.7 ERZ98041.1 - 0.02 13.9 0.7 0.021 13.8 0.5 1.0 1 0 0 1 1 1 0 Effector from type III secretion system SlyX PF04102.7 ERZ98041.1 - 0.026 14.8 5.6 0.047 14.0 1.7 2.6 2 1 1 3 3 3 0 SlyX CCDC92 PF14916.1 ERZ98041.1 - 0.038 13.5 0.6 0.038 13.5 0.4 2.0 2 1 0 2 2 2 0 Coiled-coil domain of unknown function IncA PF04156.9 ERZ98041.1 - 0.041 13.4 7.9 0.06 12.9 5.5 1.2 1 0 0 1 1 1 0 IncA protein THOC7 PF05615.8 ERZ98041.1 - 0.041 14.1 5.4 0.092 13.0 3.0 1.9 1 1 1 2 2 2 0 Tho complex subunit 7 DUF3375 PF11855.3 ERZ98041.1 - 0.046 12.4 2.2 0.057 12.1 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) APG6 PF04111.7 ERZ98041.1 - 0.046 12.7 4.8 0.053 12.5 3.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CENP-H PF05837.7 ERZ98041.1 - 0.05 13.7 4.5 0.078 13.1 3.1 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FliJ PF02050.11 ERZ98041.1 - 0.06 13.3 2.9 0.091 12.8 2.0 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein Syntaxin PF00804.20 ERZ98041.1 - 0.067 13.3 7.5 0.08 13.1 4.9 1.4 1 1 0 1 1 1 0 Syntaxin Shugoshin_N PF07558.6 ERZ98041.1 - 0.072 12.8 0.3 0.072 12.8 0.2 2.6 3 0 0 3 3 2 0 Shugoshin N-terminal coiled-coil region DUF4515 PF14988.1 ERZ98041.1 - 0.087 12.4 7.2 0.11 12.1 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) IF-2B PF01008.12 ERZ98041.1 - 0.089 11.7 1.4 0.11 11.4 1.0 1.0 1 0 0 1 1 1 0 Initiation factor 2 subunit family TSC22 PF01166.13 ERZ98041.1 - 0.098 12.6 1.0 0.098 12.6 0.7 3.0 1 1 3 4 4 4 0 TSC-22/dip/bun family DUF4140 PF13600.1 ERZ98041.1 - 0.1 13.0 2.4 0.15 12.5 1.1 1.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMF_DNA_bd PF12329.3 ERZ98041.1 - 0.11 12.3 9.1 0.33 10.7 6.3 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Vps51 PF08700.6 ERZ98041.1 - 0.11 12.3 3.0 4.2 7.2 2.0 2.6 1 1 0 1 1 1 0 Vps51/Vps67 Atg14 PF10186.4 ERZ98041.1 - 0.12 11.2 7.1 0.14 11.0 4.9 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 MAD PF05557.8 ERZ98041.1 - 0.13 10.3 7.2 0.032 12.3 0.6 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein V_ATPase_I PF01496.14 ERZ98041.1 - 0.13 10.0 3.4 0.14 10.0 2.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.1 ERZ98041.1 - 0.16 11.1 8.7 0.2 10.8 6.0 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Speriolin_N PF15058.1 ERZ98041.1 - 0.16 11.8 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Speriolin N terminus TBPIP PF07106.8 ERZ98041.1 - 0.27 10.7 7.9 0.074 12.5 1.1 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 ERZ98041.1 - 0.28 11.5 4.6 0.26 11.6 1.7 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF2681 PF10883.3 ERZ98041.1 - 0.35 11.1 3.0 3.1 8.0 2.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) FlxA PF14282.1 ERZ98041.1 - 0.47 10.4 8.9 0.57 10.1 5.8 1.5 1 1 0 1 1 1 0 FlxA-like protein DUF4200 PF13863.1 ERZ98041.1 - 0.55 10.1 8.8 1.1 9.2 6.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) AKNA PF12443.3 ERZ98041.1 - 0.59 10.1 4.6 0.95 9.5 1.0 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor DUF1319 PF07028.6 ERZ98041.1 - 0.69 10.1 6.7 1.4 9.1 4.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) FlaC_arch PF05377.6 ERZ98041.1 - 0.72 9.7 6.5 0.22 11.4 0.8 2.6 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) ACCA PF03255.9 ERZ98041.1 - 0.83 9.1 3.9 0.35 10.4 0.6 1.8 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF4404 PF14357.1 ERZ98041.1 - 0.87 10.0 6.1 3.9 7.9 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF1664 PF07889.7 ERZ98041.1 - 0.92 9.3 7.0 7.6 6.3 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-Q PF13094.1 ERZ98041.1 - 1.4 8.9 5.5 2.8 7.9 3.8 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF904 PF06005.7 ERZ98041.1 - 1.7 8.9 12.9 2.3 8.5 2.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF904) Lge1 PF11488.3 ERZ98041.1 - 2.2 8.5 5.2 3.6 7.8 3.5 1.7 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 Cep57_CLD_2 PF14197.1 ERZ98041.1 - 6.1 6.8 8.3 1.8e+02 2.1 5.8 2.8 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF16 PF01519.11 ERZ98041.1 - 6.4 7.0 7.4 40 4.5 5.4 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 rve PF00665.21 ERZ98042.1 - 0.0021 18.1 0.0 0.003 17.6 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Baculo_IE-1 PF05290.6 ERZ98044.1 - 0.0041 16.8 0.2 0.0058 16.3 0.1 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) IGF2_C PF08365.6 ERZ98045.1 - 0.054 13.2 0.7 0.082 12.6 0.5 1.3 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide DUF2031 PF09592.5 ERZ98045.1 - 0.072 12.2 0.0 0.081 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) BTB PF00651.26 ERZ98046.1 - 5e-20 71.5 0.0 5.7e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ERZ98046.1 - 0.053 12.6 0.0 0.062 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF659 PF04937.10 ERZ98047.1 - 0.00096 18.6 0.1 0.004 16.6 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF 659) Kinesin PF00225.18 ERZ98048.1 - 6.1e-109 363.7 0.0 7e-109 363.5 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain BCIP PF13862.1 ERZ98048.1 - 0.036 13.5 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 p21-C-terminal region-binding protein AAA_22 PF13401.1 ERZ98048.1 - 0.12 12.5 0.0 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain P2 PF07194.6 ERZ98048.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 P2 response regulator binding domain AAA_10 PF12846.2 ERZ98048.1 - 0.18 11.2 1.1 7.2 5.9 0.0 2.2 1 1 1 2 2 2 0 AAA-like domain DUF87 PF01935.12 ERZ98048.1 - 0.24 11.1 2.1 6.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 Glycophorin_A PF01102.13 ERZ98049.1 - 0.00024 20.8 1.7 0.00032 20.4 1.1 1.3 1 1 0 1 1 1 1 Glycophorin A DUF3611 PF12263.3 ERZ98049.1 - 0.032 13.6 0.1 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF2407_C PF13373.1 ERZ98049.1 - 0.1 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Adeno_E3_CR2 PF02439.10 ERZ98049.1 - 0.2 11.2 2.4 0.33 10.5 1.7 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ATP1G1_PLM_MAT8 PF02038.11 ERZ98049.1 - 0.79 8.7 3.2 1.2 8.2 2.2 1.2 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family PLA2_B PF01735.13 ERZ98050.1 - 0.11 10.6 1.9 0.17 10.0 0.4 1.7 1 1 1 2 2 2 0 Lysophospholipase catalytic domain ComC PF03047.9 ERZ98050.1 - 0.47 9.9 2.3 2.7 7.4 0.1 2.4 2 0 0 2 2 2 0 COMC family Clp1 PF06807.9 ERZ98052.1 - 0.13 11.9 0.1 0.14 11.8 0.1 1.1 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 CAP18_C PF12153.3 ERZ98053.1 - 0.0038 16.8 1.3 0.0065 16.0 0.9 1.3 1 0 0 1 1 1 1 LPS binding domain of CAP18 (C terminal) UBN2 PF14223.1 ERZ98053.1 - 0.03 14.0 0.2 0.042 13.6 0.1 1.3 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF3439 PF11921.3 ERZ98054.1 - 0.033 13.9 1.1 0.041 13.6 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CENP-R PF06729.7 ERZ98054.1 - 0.098 12.3 2.3 0.12 12.0 1.6 1.1 1 0 0 1 1 1 0 Kinetochore component, CENP-R Glycoprotein_G PF00802.14 ERZ98054.1 - 0.12 11.5 4.3 0.13 11.4 3.0 1.0 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G IFP_35_N PF07334.8 ERZ98055.1 - 0.0043 16.9 0.1 0.0053 16.6 0.0 1.2 1 0 0 1 1 1 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus Kinesin PF00225.18 ERZ98056.1 - 1.6e-109 365.6 0.3 1.9e-109 365.4 0.2 1.0 1 0 0 1 1 1 1 Kinesin motor domain UpxZ PF06603.6 ERZ98056.1 - 0.011 15.8 0.2 1.9 8.5 0.0 2.4 1 1 1 2 2 2 0 UpxZ family of transcription anti-terminator antagonists AAA_10 PF12846.2 ERZ98056.1 - 0.4 10.0 2.3 11 5.4 0.1 2.2 1 1 1 2 2 2 0 AAA-like domain Kinesin PF00225.18 ERZ98057.1 - 1.1e-69 234.7 0.0 1.9e-69 233.9 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ERZ98057.1 - 0.045 12.6 0.1 0.1 11.5 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF87 PF01935.12 ERZ98057.1 - 2.3 7.9 5.3 89 2.7 3.7 2.2 1 1 0 1 1 1 0 Domain of unknown function DUF87 Bacillus_HBL PF05791.6 ERZ98059.1 - 0.044 13.1 6.0 0.057 12.7 4.1 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Lipid_DES PF08557.5 ERZ98059.1 - 0.13 11.5 0.2 0.27 10.5 0.2 1.5 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) Spectrin PF00435.16 ERZ98059.1 - 0.43 10.8 9.1 0.84 9.9 5.3 1.9 1 1 1 2 2 2 0 Spectrin repeat PIN_2 PF10130.4 ERZ98059.1 - 0.47 10.4 4.8 0.58 10.1 3.4 1.1 1 0 0 1 1 1 0 PIN domain UME PF08064.8 ERZ98059.1 - 0.97 9.4 4.8 1.6 8.6 2.6 1.6 1 1 0 1 1 1 0 UME (NUC010) domain OmpH PF03938.9 ERZ98059.1 - 1.5 8.7 11.3 1.7 8.5 7.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Borrelia_P83 PF05262.6 ERZ98059.1 - 1.7 6.7 12.7 1.8 6.7 8.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein HAUS6_N PF14661.1 ERZ98059.1 - 2.4 7.4 12.5 2.1 7.6 7.9 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus TPD52 PF04201.10 ERZ98059.1 - 3.8 7.2 9.9 6.5 6.4 6.9 1.6 1 1 0 1 1 1 0 Tumour protein D52 family LMBR1 PF04791.11 ERZ98059.1 - 4.6 5.7 8.2 4.8 5.6 5.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6 PF04111.7 ERZ98059.1 - 5.3 5.9 12.7 5.7 5.8 8.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4407 PF14362.1 ERZ98059.1 - 6.2 5.6 9.7 7.5 5.4 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kinesin PF00225.18 ERZ98060.1 - 8.6e-65 218.6 0.2 9.6e-65 218.4 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Kinesin PF00225.18 ERZ98061.1 - 7.4e-61 205.6 0.7 7.4e-61 205.6 0.5 2.3 2 1 0 2 2 2 1 Kinesin motor domain DUF2681 PF10883.3 ERZ98061.1 - 0.15 12.3 11.4 4.9 7.4 0.6 4.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2681) DUF3573 PF12097.3 ERZ98061.1 - 0.23 10.0 9.9 0.036 12.6 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) RNA_pol_Rpb2_4 PF04566.8 ERZ98061.1 - 0.25 11.1 1.2 5.3 6.9 0.0 3.1 3 0 0 3 3 3 0 RNA polymerase Rpb2, domain 4 Snapin_Pallidin PF14712.1 ERZ98061.1 - 5.6 7.3 14.7 1 9.6 2.3 4.2 5 0 0 5 5 5 0 Snapin/Pallidin Syntaxin-6_N PF09177.6 ERZ98061.1 - 6.2 7.3 15.2 0.67 10.3 0.9 4.0 2 2 0 3 3 3 0 Syntaxin 6, N-terminal Thiolase_N PF00108.18 ERZ98063.1 - 1e-99 332.8 1.9 1.3e-99 332.4 1.3 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ERZ98063.1 - 2.3e-41 140.0 0.8 9.8e-41 138.0 0.0 2.4 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 ERZ98063.1 - 1.9e-06 27.5 0.4 3.7e-06 26.6 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain DUF1777 PF08648.7 ERZ98064.1 - 1.4e-23 83.5 1.4 1.5e-23 83.4 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) GTP1_OBG PF01018.17 ERZ98065.1 - 6e-41 139.7 2.2 1.1e-40 138.7 1.5 1.5 1 1 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.18 ERZ98065.1 - 1e-22 80.2 0.0 2.2e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ERZ98065.1 - 6e-09 35.3 0.1 3.2e-08 33.0 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.16 ERZ98065.1 - 9.7e-07 28.1 0.0 1.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ERZ98065.1 - 0.00019 20.6 0.0 0.00028 20.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ERZ98065.1 - 0.00025 21.5 0.0 0.00082 19.8 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein Dynamin_N PF00350.18 ERZ98065.1 - 0.00077 19.3 0.1 0.22 11.3 0.0 2.6 1 1 2 3 3 3 1 Dynamin family AAA_21 PF13304.1 ERZ98065.1 - 0.0023 17.9 0.1 0.0031 17.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.12 ERZ98065.1 - 0.015 14.8 0.0 2.3 7.7 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ArgK PF03308.11 ERZ98065.1 - 0.021 13.6 1.0 3.1 6.5 0.2 2.2 2 0 0 2 2 2 0 ArgK protein NYD-SP28_assoc PF14775.1 ERZ98065.1 - 0.021 14.5 0.1 0.045 13.4 0.1 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain MMR_HSR1_C PF08438.5 ERZ98065.1 - 0.09 13.0 0.2 0.24 11.6 0.2 1.7 2 0 0 2 2 1 0 GTPase of unknown function C-terminal Rho_Binding PF08912.6 ERZ98065.1 - 0.92 9.8 4.3 1 9.7 1.7 2.0 2 0 0 2 2 2 0 Rho Binding Coatomer_WDAD PF04053.9 ERZ98066.1 - 3e-143 477.8 0.0 6.3e-143 476.7 0.0 1.5 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.6 ERZ98066.1 - 3.2e-130 434.4 0.0 4.5e-130 433.9 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 ERZ98066.1 - 2e-54 179.6 5.9 8.7e-11 41.2 0.0 7.4 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 ERZ98066.1 - 0.011 13.8 7.0 1.7 6.6 2.9 3.6 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF2093 PF09866.4 ERZ98066.1 - 9 5.5 6.2 12 5.1 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2093) COP23 PF14218.1 ERZ98067.1 - 0.0011 18.5 3.9 4.3 6.9 0.1 4.5 5 0 0 5 5 5 2 Circadian oscillating protein COP23 Folate_rec PF03024.9 ERZ98067.1 - 0.0017 18.0 2.7 0.0022 17.6 0.0 2.2 2 0 0 2 2 2 1 Folate receptor family TraT PF05818.7 ERZ98067.1 - 0.18 11.1 2.0 41 3.4 0.0 3.3 3 0 0 3 3 3 0 Enterobacterial TraT complement resistance protein DUF4134 PF13572.1 ERZ98067.1 - 0.19 11.8 1.2 56 3.9 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4134) AP4E_app_platf PF14807.1 ERZ98067.1 - 2.5 8.3 6.2 15 5.8 0.1 3.8 3 0 0 3 3 3 0 Adaptin AP4 complex epsilon appendage platform Cas_Csa5 PF09702.5 ERZ98067.1 - 3.7 7.6 8.0 9.7 6.3 0.0 4.3 5 1 1 6 6 6 0 CRISPR-associated protein (Cas_Csa5) Fer4_8 PF13183.1 ERZ98068.1 - 0.0066 16.4 0.1 2 8.5 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain DUF2296 PF10058.4 ERZ98068.1 - 0.083 12.6 3.5 2.6 7.8 0.1 2.4 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) ecTbetaR2 PF08917.5 ERZ98068.1 - 0.12 12.1 3.4 2.2 8.0 0.1 2.2 2 0 0 2 2 2 0 Transforming growth factor beta receptor 2 ectodomain DUF3024 PF11225.3 ERZ98068.1 - 0.12 12.2 0.4 13 5.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) Cutinase PF01083.17 ERZ98068.1 - 0.45 10.2 2.6 0.58 9.8 0.1 2.0 2 0 0 2 2 2 0 Cutinase Fer4_10 PF13237.1 ERZ98068.1 - 0.75 9.6 5.1 26 4.6 4.3 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain zf-C4_ClpX PF06689.8 ERZ98068.1 - 7.1 6.2 11.5 5.2 6.6 1.0 2.3 2 0 0 2 2 2 0 ClpX C4-type zinc finger SPRY PF00622.23 ERZ98069.1 - 2e-12 47.2 0.8 2.4e-12 47.0 0.6 1.0 1 0 0 1 1 1 1 SPRY domain PS_Dcarbxylase PF02666.10 ERZ98072.1 - 3.6e-58 196.2 0.0 4.6e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Cpn10 PF00166.16 ERZ98077.1 - 0.031 14.1 0.4 0.038 13.9 0.3 1.1 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit DUF868 PF05910.7 ERZ98078.1 - 0.0049 16.3 3.4 3 7.2 0.1 3.3 1 1 2 3 3 3 3 Plant protein of unknown function (DUF868) Hemerythrin PF01814.18 ERZ98079.1 - 1.2e-07 31.8 8.8 6.1e-07 29.6 5.7 2.0 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain DUF3243 PF11588.3 ERZ98079.1 - 0.0065 16.4 0.1 0.022 14.7 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3243) Cauli_DNA-bind PF03310.8 ERZ98079.1 - 0.045 13.5 0.2 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein adh_short PF00106.20 ERZ98080.1 - 2.5e-26 92.5 0.0 3.5e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ERZ98080.1 - 1.5e-10 41.3 0.0 2.1e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ERZ98080.1 - 3.7e-09 36.4 0.0 5.7e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 ERZ98080.1 - 5.2e-05 23.3 0.0 8.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ERZ98080.1 - 0.00012 21.5 0.1 0.00033 20.1 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 ERZ98080.1 - 0.00046 19.2 0.0 0.00066 18.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Eno-Rase_NADH_b PF12242.3 ERZ98080.1 - 0.00074 19.2 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Polysacc_synt_2 PF02719.10 ERZ98080.1 - 0.0028 16.5 0.0 0.0043 15.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 ERZ98080.1 - 0.0034 16.6 0.0 0.0058 15.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family DUF1776 PF08643.5 ERZ98080.1 - 0.074 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Spt5_N PF11942.3 ERZ98082.1 - 1.2 9.7 7.2 1.5 9.4 5.0 1.3 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal OTOS PF15182.1 ERZ98083.1 - 0.063 12.9 0.1 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Otospiralin PBP1_TM PF14812.1 ERZ98083.1 - 2.9 8.2 9.2 9.5 6.6 6.4 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase_Tyr PF07714.12 ERZ98084.1 - 1.1e-18 67.3 0.1 7.3e-18 64.5 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98084.1 - 2.2e-12 46.7 0.0 1.3e-11 44.1 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain AhpC-TSA PF00578.16 ERZ98085.1 - 2.9e-33 114.1 0.0 3.8e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ERZ98085.1 - 1.6e-11 43.9 0.0 2.1e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 ERZ98085.1 - 7e-11 41.5 0.0 1.2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SMC_N PF02463.14 ERZ98086.1 - 1.2e-66 224.1 4.2 5.2e-66 222.0 2.9 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ERZ98086.1 - 8e-32 109.7 0.0 3.2e-31 107.8 0.0 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 ERZ98086.1 - 2.9e-08 34.0 32.2 1.7e-05 24.9 3.9 5.0 2 2 0 3 3 3 2 AAA domain AAA_29 PF13555.1 ERZ98086.1 - 8.1e-08 31.6 0.0 1.9e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ERZ98086.1 - 6.6e-05 22.1 14.0 6.6e-05 22.1 9.7 5.1 2 2 1 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.1 ERZ98086.1 - 0.0015 18.4 0.0 0.006 16.4 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.22 ERZ98086.1 - 0.14 12.4 0.0 0.14 12.4 0.0 5.7 4 2 0 4 4 4 0 ABC transporter Reo_sigmaC PF04582.7 ERZ98086.1 - 0.15 11.2 19.4 0.9 8.6 0.5 4.1 2 2 2 4 4 4 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 ERZ98086.1 - 2.4 6.5 102.0 0.028 12.9 12.1 6.0 3 2 3 6 6 6 0 AAA domain Ribosomal_S7 PF00177.16 ERZ98087.1 - 3e-41 140.4 0.6 3.7e-41 140.1 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF3099 PF11298.3 ERZ98089.1 - 0.22 11.3 0.2 0.22 11.3 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) F-box-like PF12937.2 ERZ98090.1 - 0.0026 17.4 0.7 0.0026 17.4 0.5 2.1 2 0 0 2 2 2 1 F-box-like DUF2621 PF11084.3 ERZ98091.1 - 0.016 14.9 0.4 0.031 13.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) Arch_ATPase PF01637.13 ERZ98092.1 - 4.6e-06 26.4 2.6 8.8e-06 25.5 0.2 2.2 3 0 0 3 3 3 1 Archaeal ATPase AAA_14 PF13173.1 ERZ98092.1 - 4.7e-06 26.5 0.7 0.00018 21.3 0.5 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ERZ98092.1 - 1.2e-05 25.3 0.1 0.00013 22.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_35 PF14516.1 ERZ98092.1 - 8.3e-05 21.3 0.3 0.00015 20.5 0.0 1.5 2 0 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 ERZ98092.1 - 8.7e-05 22.6 0.0 0.00016 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ98092.1 - 0.00069 19.8 0.1 0.0035 17.5 0.0 2.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) KTI12 PF08433.5 ERZ98092.1 - 0.0026 17.0 0.0 0.0047 16.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA-ATPase_like PF09820.4 ERZ98092.1 - 0.0087 15.2 1.4 0.0099 15.0 0.1 1.7 2 1 0 2 2 2 1 Predicted AAA-ATPase AAA_17 PF13207.1 ERZ98092.1 - 0.097 13.4 0.8 0.92 10.3 0.0 2.5 2 2 0 2 2 2 0 AAA domain HrcA PF01628.16 ERZ98095.1 - 0.099 12.2 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 HrcA protein C terminal domain H_lectin PF09458.5 ERZ98096.1 - 0.11 12.1 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 H-type lectin domain CM_2 PF01817.16 ERZ98097.1 - 3e-09 36.8 0.6 1.4e-06 28.2 0.0 3.0 3 1 0 3 3 3 2 Chorismate mutase type II DUF4127 PF13552.1 ERZ98097.1 - 0.03 12.7 0.0 0.048 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) FAD_syn PF06574.7 ERZ98097.1 - 0.039 13.5 0.0 5.7 6.5 0.0 2.2 2 0 0 2 2 2 0 FAD synthetase Ribosomal_S5_C PF03719.10 ERZ98098.1 - 3.2e-20 71.2 0.0 4.9e-19 67.3 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 ERZ98098.1 - 2.6e-18 65.5 0.4 4.1e-18 64.8 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Tic20 PF09685.5 ERZ98099.1 - 3.2e-05 23.8 1.7 4.3e-05 23.4 1.1 1.2 1 0 0 1 1 1 1 Tic20-like protein Bax1-I PF01027.15 ERZ98099.1 - 0.0072 15.9 1.1 0.0098 15.5 0.8 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Glyco_trans_2_3 PF13632.1 ERZ98099.1 - 0.019 14.6 0.3 0.024 14.3 0.2 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 YfhO PF09586.5 ERZ98099.1 - 0.054 11.5 0.7 0.068 11.1 0.5 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF3329 PF11808.3 ERZ98099.1 - 3.5 7.7 5.2 3.4 7.8 2.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3329) LRR_4 PF12799.2 ERZ98100.1 - 0.052 13.1 3.5 2.3 7.9 0.4 3.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ98100.1 - 0.28 11.3 4.8 5.2 7.4 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich repeat SPRY PF00622.23 ERZ98101.1 - 7e-11 42.2 0.1 1.2e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ98101.1 - 7.8e-07 29.0 0.1 1.7e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF1029 PF06269.7 ERZ98102.1 - 0.15 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1029) DUF1672 PF07901.6 ERZ98103.1 - 0.062 12.2 2.6 0.064 12.2 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) GAS PF13851.1 ERZ98104.1 - 0.0014 17.9 8.7 0.0028 16.8 6.1 1.5 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 ERZ98104.1 - 0.0044 16.8 10.4 0.0094 15.8 7.2 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 ERZ98104.1 - 0.028 14.0 5.9 0.045 13.3 4.1 1.3 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ERZ98104.1 - 0.051 13.5 13.2 0.097 12.6 0.5 3.3 1 1 2 3 3 3 0 bZIP transcription factor bZIP_2 PF07716.10 ERZ98104.1 - 0.052 13.3 17.5 0.13 12.1 1.1 3.8 1 1 3 4 4 4 0 Basic region leucine zipper DUF904 PF06005.7 ERZ98104.1 - 0.069 13.4 14.3 0.16 12.2 2.8 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF904) YcbB PF08664.5 ERZ98104.1 - 0.078 12.7 0.9 43 3.8 0.0 3.4 2 1 1 3 3 3 0 YcbB domain DUF334 PF03904.8 ERZ98104.1 - 0.14 11.4 4.8 0.078 12.2 1.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF334) Gal4_dimer PF03902.8 ERZ98104.1 - 0.3 11.0 2.4 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 Gal4-like dimerisation domain DivIC PF04977.10 ERZ98104.1 - 0.39 10.2 14.9 1.1 8.8 0.9 3.2 1 1 2 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.3 ERZ98104.1 - 0.45 10.3 17.1 1.1 9.0 9.5 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 ERZ98104.1 - 1.4 7.8 9.4 0.13 11.1 3.3 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 KIAA1430 PF13879.1 ERZ98104.1 - 1.5 9.3 12.0 0.57 10.6 0.8 3.2 2 1 1 3 3 3 0 KIAA1430 homologue DUF4164 PF13747.1 ERZ98104.1 - 1.7 8.8 10.1 54 4.0 0.0 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) Ax_dynein_light PF10211.4 ERZ98104.1 - 6.6 6.5 13.5 1.2 8.9 3.8 2.7 2 1 1 3 3 3 0 Axonemal dynein light chain bZIP_1 PF00170.16 ERZ98106.1 - 3.5e-12 46.0 14.5 3.5e-12 46.0 10.0 2.6 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.10 ERZ98106.1 - 1.4e-10 40.7 12.9 1.4e-10 40.7 9.0 3.2 2 1 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 ERZ98106.1 - 0.00067 19.9 11.4 0.00067 19.9 7.9 3.4 3 1 1 4 4 4 1 bZIP Maf transcription factor Tic20 PF09685.5 ERZ98107.1 - 0.076 13.0 3.9 0.18 11.8 2.7 1.6 1 0 0 1 1 1 0 Tic20-like protein DUF2244 PF10003.4 ERZ98107.1 - 0.1 11.9 0.5 0.17 11.2 0.4 1.2 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Asp_protease_2 PF13650.1 ERZ98109.1 - 0.0037 17.7 0.0 0.0066 16.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease HECT PF00632.20 ERZ98112.1 - 6.6e-07 28.7 0.1 1.2e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Auto_anti-p27 PF06677.7 ERZ98112.1 - 0.23 11.2 3.1 0.39 10.5 2.1 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NmrA PF05368.8 ERZ98113.1 - 2.5e-33 115.2 0.2 3e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ98113.1 - 1.5e-12 47.8 0.0 2.3e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ERZ98113.1 - 1.4e-06 28.2 0.1 6.7e-06 26.1 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 ERZ98113.1 - 1.6e-06 27.9 0.0 4.4e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.14 ERZ98113.1 - 2.8e-05 22.9 0.0 5.2e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 ERZ98113.1 - 0.00017 20.6 0.0 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Epimerase PF01370.16 ERZ98113.1 - 0.00026 20.5 0.0 0.00053 19.4 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 ERZ98113.1 - 0.015 15.2 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.12 ERZ98113.1 - 0.023 15.0 0.1 0.087 13.2 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 ERZ98113.1 - 0.037 13.9 0.1 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 ERZ98113.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein Shikimate_DH PF01488.15 ERZ98113.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF3842 PF12953.2 ERZ98113.1 - 0.14 12.3 0.0 18 5.5 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3842) HMG_box PF00505.14 ERZ98114.1 - 2.3e-05 24.5 0.2 4.2e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ98114.1 - 0.013 15.8 0.2 0.022 15.1 0.2 1.4 1 0 0 1 1 1 0 HMG-box domain Sod_Ni PF09055.6 ERZ98115.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase FBP PF07299.6 ERZ98122.1 - 0.66 9.2 7.6 0.16 11.2 1.0 2.1 1 1 1 2 2 2 0 Fibronectin-binding protein (FBP) OTU PF02338.14 ERZ98125.1 - 0.00088 19.8 0.4 0.0016 19.0 0.2 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease NinG PF05766.7 ERZ98125.1 - 0.06 13.0 7.2 0.13 11.9 0.0 2.9 3 0 0 3 3 3 0 Bacteriophage Lambda NinG protein DUF1640 PF07798.6 ERZ98125.1 - 0.085 12.8 4.1 0.087 12.8 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) IL15 PF02372.10 ERZ98125.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.6 3 0 0 3 3 3 0 Interleukin 15 CR6_interact PF10147.4 ERZ98125.1 - 0.32 10.2 5.4 0.074 12.3 1.2 1.7 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF2681 PF10883.3 ERZ98125.1 - 1.9 8.7 4.7 5.5 7.2 3.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF1002 PF06207.6 ERZ98125.1 - 2.2 7.5 8.2 3 7.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) DUF334 PF03904.8 ERZ98125.1 - 5.2 6.3 8.6 0.2 10.9 1.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF334) Uds1 PF15456.1 ERZ98125.1 - 7.9 6.4 11.4 2.4 8.1 3.7 2.4 2 1 0 2 2 2 0 Up-regulated During Septation Zn_ribbon_2 PF12674.2 ERZ98126.1 - 0.092 13.1 0.2 1.5 9.2 0.0 2.1 2 0 0 2 2 2 0 Putative zinc ribbon domain Shugoshin_N PF07558.6 ERZ98127.1 - 0.053 13.2 4.0 0.42 10.3 1.7 3.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region NOA36 PF06524.7 ERZ98127.1 - 0.4 9.8 3.6 0.89 8.7 2.5 1.5 1 0 0 1 1 1 0 NOA36 protein TSC22 PF01166.13 ERZ98127.1 - 4.6 7.2 15.9 0.15 12.0 4.7 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family ATG16 PF08614.6 ERZ98127.1 - 4.8 6.9 21.3 1.2 8.9 0.6 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) WD40 PF00400.27 ERZ98128.1 - 2.7e-10 39.6 9.2 1.3e-06 28.0 0.2 5.2 5 1 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 ERZ98128.1 - 7.6e-05 22.5 0.0 0.13 11.9 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A DNA_alkylation PF08713.6 ERZ98129.1 - 8.8e-52 175.6 0.5 1.1e-51 175.3 0.3 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme Myb_DNA-binding PF00249.26 ERZ98130.1 - 0.00055 19.9 0.0 0.0016 18.4 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ98130.1 - 0.00077 19.5 0.1 0.0082 16.2 0.0 2.5 2 1 0 2 2 2 1 Myb-like DNA-binding domain TMF_TATA_bd PF12325.3 ERZ98130.1 - 0.0028 17.3 1.8 0.0028 17.3 1.2 1.8 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding FlxA PF14282.1 ERZ98130.1 - 0.019 14.9 7.2 0.019 14.9 5.0 2.0 1 1 0 1 1 1 0 FlxA-like protein Rotamase_2 PF13145.1 ERZ98130.1 - 0.04 14.5 2.3 0.06 13.9 1.6 1.4 1 0 0 1 1 1 0 PPIC-type PPIASE domain DUF3573 PF12097.3 ERZ98130.1 - 0.65 8.5 3.8 0.96 7.9 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) RP-C_C PF11800.3 ERZ98130.1 - 0.74 9.4 10.3 1.5 8.4 7.1 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region IncA PF04156.9 ERZ98130.1 - 1 8.9 4.4 1.7 8.1 3.0 1.3 1 0 0 1 1 1 0 IncA protein LMBR1 PF04791.11 ERZ98130.1 - 2.3 6.6 6.9 3.1 6.2 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.1 ERZ98130.1 - 3.9 6.3 5.2 5.2 5.9 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) POX PF07526.6 ERZ98130.1 - 7.3 6.8 7.1 13 5.9 4.9 1.5 1 0 0 1 1 1 0 Associated with HOX PHP PF02811.14 ERZ98131.1 - 2.3e-11 43.8 0.2 6.9e-11 42.2 0.1 1.8 1 1 1 2 2 2 1 PHP domain PAZ PF02170.17 ERZ98131.1 - 0.015 14.5 1.9 3.6 6.9 0.0 2.5 1 1 0 2 2 2 0 PAZ domain DUF2431 PF10354.4 ERZ98131.1 - 0.058 13.3 0.8 0.38 10.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) DUF2623 PF11115.3 ERZ98131.1 - 0.091 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2623) CH PF00307.26 ERZ98132.1 - 2.2e-18 66.2 0.2 3.3e-10 39.9 0.0 2.7 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 ERZ98132.1 - 0.00083 18.9 0.1 0.89 9.2 0.0 3.2 2 1 0 2 2 2 2 CAMSAP CH domain Stimulus_sens_1 PF13756.1 ERZ98132.1 - 0.027 14.8 0.3 0.26 11.6 0.0 2.5 2 0 0 2 2 2 0 Stimulus-sensing domain DUF2622 PF11080.3 ERZ98132.1 - 1.5 8.7 4.6 14 5.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2622) zf-Tim10_DDP PF02953.10 ERZ98133.1 - 8.1e-22 76.2 0.1 1e-21 75.9 0.1 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Rad60-SLD PF11976.3 ERZ98134.1 - 6.7e-18 64.1 2.3 1.3e-12 47.1 0.8 2.6 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like XisI PF08869.6 ERZ98134.1 - 0.045 13.8 0.6 19 5.4 0.0 2.9 2 1 1 3 3 3 0 XisI protein Arb2 PF09757.4 ERZ98134.1 - 0.048 13.0 0.4 0.08 12.3 0.2 1.3 1 0 0 1 1 1 0 Arb2 domain ubiquitin PF00240.18 ERZ98134.1 - 0.11 11.8 3.1 1.1 8.6 0.6 2.8 2 1 0 3 3 3 0 Ubiquitin family FAM178 PF14816.1 ERZ98134.1 - 0.31 9.6 3.3 0.42 9.2 2.3 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 TB2_DP1_HVA22 PF03134.14 ERZ98136.1 - 1.7e-31 107.7 7.7 2.6e-31 107.2 5.3 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Mre11_DNA_bind PF04152.9 ERZ98137.1 - 5.5e-23 81.7 0.2 1.1e-22 80.7 0.1 1.5 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 ERZ98137.1 - 1.5e-20 73.4 5.0 3.1e-20 72.4 3.5 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase API5 PF05918.6 ERZ98137.1 - 2.2 6.6 21.7 0.48 8.8 3.3 2.3 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) IncA PF04156.9 ERZ98139.1 - 2.2e-07 30.6 10.4 2.2e-07 30.6 7.2 1.7 2 0 0 2 2 1 1 IncA protein Laminin_II PF06009.7 ERZ98139.1 - 2.8e-06 27.1 9.3 2.8e-06 27.1 6.4 1.8 2 0 0 2 2 1 1 Laminin Domain II Laminin_I PF06008.9 ERZ98139.1 - 1.1e-05 24.8 10.9 5.2e-05 22.6 5.5 2.3 2 1 0 2 2 2 1 Laminin Domain I TMF_DNA_bd PF12329.3 ERZ98139.1 - 2.6e-05 23.9 28.0 3.5e-05 23.5 14.5 2.6 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.4 ERZ98139.1 - 4.1e-05 23.6 12.3 4.1e-05 23.6 8.5 2.3 2 1 0 2 2 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 ERZ98139.1 - 8.4e-05 21.9 0.5 0.00012 21.3 0.3 1.2 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Prominin PF05478.6 ERZ98139.1 - 0.00011 19.8 6.4 0.00016 19.4 4.4 1.2 1 0 0 1 1 1 1 Prominin CENP-F_leu_zip PF10473.4 ERZ98139.1 - 0.00012 21.9 14.3 0.00012 21.9 9.9 2.4 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 ERZ98139.1 - 0.00015 20.4 10.8 0.00015 20.4 7.5 1.8 2 0 0 2 2 2 1 AAA domain Taxilin PF09728.4 ERZ98139.1 - 0.00028 20.0 13.1 0.00028 20.0 9.1 1.7 2 0 0 2 2 1 1 Myosin-like coiled-coil protein Baculo_PEP_C PF04513.7 ERZ98139.1 - 0.00032 20.5 1.3 0.00073 19.3 0.9 1.5 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 ERZ98139.1 - 0.00066 19.2 13.0 0.00066 19.2 9.0 2.3 2 0 0 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NPV_P10 PF05531.7 ERZ98139.1 - 0.00074 19.7 19.5 0.0036 17.5 3.8 2.8 2 1 1 3 3 2 2 Nucleopolyhedrovirus P10 protein Spc7 PF08317.6 ERZ98139.1 - 0.00077 18.2 14.6 0.00077 18.2 10.1 1.9 1 1 1 2 2 2 1 Spc7 kinetochore protein EzrA PF06160.7 ERZ98139.1 - 0.0012 17.1 7.9 0.0012 17.1 5.4 1.6 2 0 0 2 2 1 1 Septation ring formation regulator, EzrA Tropomyosin PF00261.15 ERZ98139.1 - 0.0013 17.8 21.0 0.0065 15.5 11.7 2.3 1 1 1 2 2 2 1 Tropomyosin Bacillus_HBL PF05791.6 ERZ98139.1 - 0.0016 17.8 8.2 0.0016 17.8 5.7 2.4 3 0 0 3 3 2 1 Bacillus haemolytic enterotoxin (HBL) DUF4363 PF14276.1 ERZ98139.1 - 0.0022 17.7 11.8 0.0025 17.5 0.1 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4363) DUF3450 PF11932.3 ERZ98139.1 - 0.0023 17.2 2.4 0.0041 16.4 1.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) APG6 PF04111.7 ERZ98139.1 - 0.0036 16.4 10.0 0.0036 16.4 6.9 1.7 2 0 0 2 2 2 1 Autophagy protein Apg6 MCPsignal PF00015.16 ERZ98139.1 - 0.0036 16.8 0.8 0.0068 15.9 0.5 1.4 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.6 ERZ98139.1 - 0.0041 16.9 7.1 0.0041 16.9 4.9 3.1 2 1 1 3 3 2 1 Flagella accessory protein C (FlaC) DUF4201 PF13870.1 ERZ98139.1 - 0.0048 16.3 14.4 0.0048 16.3 10.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) DUF4200 PF13863.1 ERZ98139.1 - 0.0053 16.6 14.1 0.0053 16.6 9.8 2.3 3 0 0 3 3 1 1 Domain of unknown function (DUF4200) DASH_Dam1 PF08653.5 ERZ98139.1 - 0.0055 16.4 2.3 2.1 8.1 0.1 2.6 1 1 1 2 2 2 0 DASH complex subunit Dam1 Vps51 PF08700.6 ERZ98139.1 - 0.0058 16.4 4.8 0.039 13.7 3.3 2.4 1 1 0 1 1 1 1 Vps51/Vps67 Cauli_AT PF03233.8 ERZ98139.1 - 0.0059 16.3 17.2 0.0091 15.7 8.5 2.3 2 0 0 2 2 2 1 Aphid transmission protein ATG16 PF08614.6 ERZ98139.1 - 0.0075 16.1 9.9 0.0075 16.1 6.9 1.8 2 0 0 2 2 1 1 Autophagy protein 16 (ATG16) ADIP PF11559.3 ERZ98139.1 - 0.0075 16.1 12.7 0.0075 16.1 8.8 1.8 2 0 0 2 2 1 1 Afadin- and alpha -actinin-Binding MbeD_MobD PF04899.7 ERZ98139.1 - 0.0076 16.1 0.6 0.34 10.8 0.2 2.8 1 1 1 2 2 2 1 MbeD/MobD like RmuC PF02646.11 ERZ98139.1 - 0.0083 14.9 5.6 0.0083 14.9 3.9 2.0 2 0 0 2 2 1 1 RmuC family Mnd1 PF03962.10 ERZ98139.1 - 0.0085 15.7 9.3 0.0085 15.7 6.4 1.7 2 0 0 2 2 1 1 Mnd1 family ISG65-75 PF11727.3 ERZ98139.1 - 0.0092 15.0 7.5 0.0092 15.0 5.2 1.9 2 1 0 2 2 2 1 Invariant surface glycoprotein TPR_MLP1_2 PF07926.7 ERZ98139.1 - 0.0099 15.6 11.4 0.015 15.0 7.5 1.5 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.16 ERZ98139.1 - 0.016 15.1 18.9 0.02 14.8 5.5 2.9 1 1 1 2 2 2 0 bZIP transcription factor DUF1465 PF07323.7 ERZ98139.1 - 0.017 14.6 1.6 0.04 13.4 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) PEARLI-4 PF05278.7 ERZ98139.1 - 0.018 14.4 14.2 0.036 13.4 9.8 1.4 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) SlyX PF04102.7 ERZ98139.1 - 0.019 15.3 5.1 0.026 14.8 1.1 2.4 1 1 1 2 2 2 0 SlyX Gp-FAR-1 PF05823.7 ERZ98139.1 - 0.027 14.4 11.6 0.063 13.2 8.1 1.6 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Fmp27_WPPW PF10359.4 ERZ98139.1 - 0.032 12.6 13.4 0.0097 14.3 5.4 2.0 1 1 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF677 PF05055.7 ERZ98139.1 - 0.035 12.7 8.7 0.022 13.4 4.6 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF677) Allexi_40kDa PF05549.6 ERZ98139.1 - 0.038 13.2 3.0 0.075 12.3 2.1 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Tropomyosin_1 PF12718.2 ERZ98139.1 - 0.042 13.6 24.0 0.19 11.6 15.8 2.4 1 1 0 1 1 1 0 Tropomyosin like Phage_GP20 PF06810.6 ERZ98139.1 - 0.045 13.1 23.6 0.029 13.8 10.7 3.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 Herpes_U30 PF04523.8 ERZ98139.1 - 0.046 11.1 0.8 0.072 10.5 0.5 1.2 1 0 0 1 1 1 0 Herpes virus tegument protein U30 FbpA PF05833.6 ERZ98139.1 - 0.053 12.0 12.8 0.04 12.4 7.3 1.7 2 0 0 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) Synaptobrevin PF00957.16 ERZ98139.1 - 0.055 13.0 11.7 0.082 12.5 3.9 3.1 2 1 1 3 3 3 0 Synaptobrevin DASH_Dad3 PF08656.5 ERZ98139.1 - 0.066 12.9 7.8 42 3.9 5.3 4.0 2 1 0 2 2 2 0 DASH complex subunit Dad3 PspA_IM30 PF04012.7 ERZ98139.1 - 0.074 12.3 13.2 0.077 12.3 6.8 2.1 1 1 1 2 2 2 0 PspA/IM30 family PTRF_SDPR PF15237.1 ERZ98139.1 - 0.076 12.4 18.6 0.14 11.5 12.9 1.4 1 1 0 1 1 1 0 PTRF/SDPR family Sipho_Gp157 PF05565.6 ERZ98139.1 - 0.076 12.5 12.2 0.17 11.4 8.5 1.6 1 0 0 1 1 1 0 Siphovirus Gp157 GP41 PF00517.12 ERZ98139.1 - 0.088 12.3 2.0 0.22 11.0 1.4 1.7 1 0 0 1 1 1 0 Retroviral envelope protein HemX PF04375.9 ERZ98139.1 - 0.1 11.1 3.6 0.16 10.4 2.5 1.2 1 0 0 1 1 1 0 HemX DUF948 PF06103.6 ERZ98139.1 - 0.12 12.2 11.3 0.13 12.1 6.4 2.2 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.8 ERZ98139.1 - 0.12 11.3 11.9 0.079 12.0 4.8 2.0 2 0 0 2 2 2 0 TMPIT-like protein DivIC PF04977.10 ERZ98139.1 - 0.13 11.7 18.6 7 6.2 11.4 2.9 2 1 0 2 2 1 0 Septum formation initiator Cast PF10174.4 ERZ98139.1 - 0.15 10.0 18.1 0.0079 14.3 8.9 1.4 2 0 0 2 2 1 0 RIM-binding protein of the cytomatrix active zone DUF1664 PF07889.7 ERZ98139.1 - 0.15 11.8 17.2 0.12 12.1 5.9 2.8 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 ERZ98139.1 - 0.15 10.9 15.9 0.011 14.7 7.6 1.6 2 0 0 2 2 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_27 PF13514.1 ERZ98139.1 - 0.17 9.5 8.1 0.031 11.9 2.8 1.7 2 0 0 2 2 2 0 AAA domain DASH_Duo1 PF08651.5 ERZ98139.1 - 0.18 11.4 6.9 0.91 9.1 1.5 2.8 2 1 1 3 3 2 0 DASH complex subunit Duo1 DUF2935 PF11155.3 ERZ98139.1 - 0.19 11.8 7.9 0.17 11.9 2.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF2802 PF10975.3 ERZ98139.1 - 0.21 11.3 5.5 28 4.5 2.2 4.1 2 2 0 2 2 2 0 Protein of unknown function (DUF2802) Nup54 PF13874.1 ERZ98139.1 - 0.22 11.1 8.3 0.54 9.9 3.7 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF745 PF05335.8 ERZ98139.1 - 0.22 11.0 3.5 0.48 9.9 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CENP-Q PF13094.1 ERZ98139.1 - 0.24 11.4 17.1 1.2 9.1 10.3 2.7 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF972 PF06156.8 ERZ98139.1 - 0.24 11.7 17.1 0.061 13.6 8.1 2.7 2 2 0 2 2 1 0 Protein of unknown function (DUF972) Syntaxin-6_N PF09177.6 ERZ98139.1 - 0.26 11.7 7.7 0.075 13.4 2.8 2.0 2 1 0 2 2 1 0 Syntaxin 6, N-terminal Myosin_tail_1 PF01576.14 ERZ98139.1 - 0.26 8.9 19.7 0.0073 14.0 9.5 1.4 2 0 0 2 2 1 0 Myosin tail DUF4446 PF14584.1 ERZ98139.1 - 0.26 11.0 6.6 0.94 9.2 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) Sec34 PF04136.10 ERZ98139.1 - 0.27 10.9 6.3 0.094 12.4 1.9 2.0 2 0 0 2 2 1 0 Sec34-like family DUF2968 PF11180.3 ERZ98139.1 - 0.27 10.5 3.2 0.24 10.7 1.1 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF2968) Cluap1 PF10234.4 ERZ98139.1 - 0.3 10.2 13.9 0.11 11.6 7.7 1.6 2 0 0 2 2 1 0 Clusterin-associated protein-1 Mod_r PF07200.8 ERZ98139.1 - 0.3 10.9 13.7 0.037 13.9 6.5 1.6 2 0 0 2 2 1 0 Modifier of rudimentary (Mod(r)) protein DUF4413 PF14372.1 ERZ98139.1 - 0.32 11.0 7.4 1.1 9.2 0.0 3.2 3 1 0 3 3 2 0 Domain of unknown function (DUF4413) COG5 PF10392.4 ERZ98139.1 - 0.32 10.9 7.6 0.13 12.2 2.6 2.3 2 1 0 2 2 1 0 Golgi transport complex subunit 5 IFT57 PF10498.4 ERZ98139.1 - 0.33 9.6 14.1 0.068 11.8 6.5 2.1 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 DUF4618 PF15397.1 ERZ98139.1 - 0.33 10.2 16.5 0.26 10.5 9.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF3584 PF12128.3 ERZ98139.1 - 0.34 8.1 12.6 1.1 6.5 8.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ACCA PF03255.9 ERZ98139.1 - 0.35 10.4 15.5 5.3 6.5 7.6 3.1 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GAS PF13851.1 ERZ98139.1 - 0.36 9.9 22.7 0.021 14.0 10.7 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med9 PF07544.8 ERZ98139.1 - 0.36 10.5 11.5 0.19 11.4 5.8 2.2 2 0 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 LXG PF04740.7 ERZ98139.1 - 0.39 10.4 10.4 0.27 11.0 4.4 2.4 2 0 0 2 2 2 0 LXG domain of WXG superfamily Jnk-SapK_ap_N PF09744.4 ERZ98139.1 - 0.39 10.6 17.5 0.089 12.7 8.1 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF489 PF04356.7 ERZ98139.1 - 0.42 10.1 2.5 0.85 9.1 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF848 PF05852.6 ERZ98139.1 - 0.42 10.4 11.3 0.08 12.7 4.8 2.0 2 1 0 2 2 1 0 Gammaherpesvirus protein of unknown function (DUF848) PspB PF06667.7 ERZ98139.1 - 0.43 10.5 4.9 34 4.4 3.4 2.6 1 1 0 1 1 1 0 Phage shock protein B DUF3629 PF12302.3 ERZ98139.1 - 0.45 9.8 4.9 0.65 9.3 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3629) Noelin-1 PF12308.3 ERZ98139.1 - 0.45 10.3 4.9 4 7.2 2.0 2.6 2 0 0 2 2 2 0 Neurogenesis glycoprotein Med4 PF10018.4 ERZ98139.1 - 0.46 9.8 12.4 0.12 11.7 6.0 1.9 2 0 0 2 2 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4407 PF14362.1 ERZ98139.1 - 0.52 9.2 2.7 0.78 8.6 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EMP24_GP25L PF01105.19 ERZ98139.1 - 0.53 9.9 10.4 0.13 11.9 4.3 2.1 2 1 0 2 2 1 0 emp24/gp25L/p24 family/GOLD Sec8_exocyst PF04048.9 ERZ98139.1 - 0.54 9.8 8.7 1.1 8.8 6.0 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Syntaxin_2 PF14523.1 ERZ98139.1 - 0.54 10.3 17.1 0.92 9.5 7.1 3.2 3 1 0 3 3 2 0 Syntaxin-like protein DUF812 PF05667.6 ERZ98139.1 - 0.55 8.6 14.8 0.022 13.3 6.3 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF812) DUF2730 PF10805.3 ERZ98139.1 - 0.57 9.9 10.9 3.9 7.2 6.6 2.8 2 1 0 2 2 1 0 Protein of unknown function (DUF2730) phiKZ_IP PF12699.2 ERZ98139.1 - 0.58 9.0 14.6 5 5.9 10.1 2.4 1 1 0 1 1 1 0 phiKZ-like phage internal head proteins YscO PF07321.7 ERZ98139.1 - 0.6 9.9 14.5 0.62 9.8 6.9 2.5 2 1 1 3 3 3 0 Type III secretion protein YscO COG2 PF06148.6 ERZ98139.1 - 0.62 9.9 13.3 0.25 11.1 6.6 2.3 2 1 0 2 2 1 0 COG (conserved oligomeric Golgi) complex component, COG2 CALCOCO1 PF07888.6 ERZ98139.1 - 0.63 8.2 10.1 0.13 10.5 4.6 1.5 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF641 PF04859.7 ERZ98139.1 - 0.63 9.7 12.0 0.14 11.9 5.2 2.1 2 1 1 3 3 1 0 Plant protein of unknown function (DUF641) Phage_GPO PF05929.6 ERZ98139.1 - 0.71 9.0 6.5 0.59 9.3 2.8 1.9 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ERM PF00769.14 ERZ98139.1 - 0.72 9.3 15.9 0.22 11.0 8.2 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family GLE1 PF07817.8 ERZ98139.1 - 0.74 8.6 5.7 1.5 7.6 4.0 1.4 1 0 0 1 1 1 0 GLE1-like protein DUF241 PF03087.9 ERZ98139.1 - 0.75 9.2 15.7 0.083 12.3 7.9 1.6 2 0 0 2 2 1 0 Arabidopsis protein of unknown function DUF3086 PF11285.3 ERZ98139.1 - 0.82 8.4 6.5 0.19 10.5 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) Cob_adeno_trans PF01923.13 ERZ98139.1 - 0.83 9.4 3.3 1.2 8.9 1.1 2.1 3 0 0 3 3 1 0 Cobalamin adenosyltransferase Vac_Fusion PF02346.11 ERZ98139.1 - 0.86 9.0 8.7 3.1 7.2 3.5 2.7 1 1 1 2 2 2 0 Chordopoxvirus fusion protein Lge1 PF11488.3 ERZ98139.1 - 0.89 9.7 12.6 0.24 11.6 6.2 2.0 2 0 0 2 2 1 0 Transcriptional regulatory protein LGE1 DUF1515 PF07439.6 ERZ98139.1 - 0.96 9.2 6.6 1.3 8.8 1.9 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF1515) Occludin_ELL PF07303.8 ERZ98139.1 - 1.1 10.0 15.4 0.13 12.9 5.6 2.9 2 1 1 3 3 1 0 Occludin homology domain FliJ PF02050.11 ERZ98139.1 - 1.2 9.2 11.3 0.93 9.5 5.6 2.3 2 1 0 2 2 1 0 Flagellar FliJ protein Tweety PF04906.8 ERZ98139.1 - 1.2 7.4 4.8 0.54 8.6 1.5 1.6 2 0 0 2 2 2 0 Tweety Ax_dynein_light PF10211.4 ERZ98139.1 - 1.2 8.8 17.2 0.41 10.4 8.3 2.3 1 1 1 2 2 2 0 Axonemal dynein light chain Spectrin PF00435.16 ERZ98139.1 - 1.3 9.3 13.1 0.78 10.0 6.3 2.5 2 1 0 2 2 1 0 Spectrin repeat DUF3251 PF11622.3 ERZ98139.1 - 1.5 8.1 3.4 3.5 7.0 1.2 2.3 2 1 0 2 2 1 0 Protein of unknown function (DUF3251) Snapin_Pallidin PF14712.1 ERZ98139.1 - 1.5 9.1 16.3 0.32 11.3 7.4 2.7 2 1 0 2 2 1 0 Snapin/Pallidin V_ATPase_I PF01496.14 ERZ98139.1 - 1.6 6.4 17.4 4.8 4.9 11.9 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family STAT_alpha PF01017.15 ERZ98139.1 - 1.8 8.2 12.6 33 4.1 6.5 3.0 2 1 0 2 2 2 0 STAT protein, all-alpha domain Hemagglutinin PF00509.13 ERZ98139.1 - 1.8 6.6 6.6 3 5.8 4.3 1.5 1 1 0 1 1 1 0 Haemagglutinin DUF3552 PF12072.3 ERZ98139.1 - 1.8 7.7 22.4 0.16 11.1 10.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Seryl_tRNA_N PF02403.17 ERZ98139.1 - 1.9 8.5 25.1 0.25 11.3 11.6 3.0 1 1 3 4 4 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.1 ERZ98139.1 - 1.9 8.9 8.2 3.7 8.0 4.3 2.4 2 1 0 2 2 1 0 N-terminal domain of unknown function (DUF4140) IZUMO PF15005.1 ERZ98139.1 - 2.3 8.2 7.9 3.5 7.6 3.7 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion CK2S PF15011.1 ERZ98139.1 - 2.3 7.9 6.4 11 5.7 4.4 2.2 1 1 0 1 1 1 0 Casein Kinase 2 substrate PhoU PF01895.14 ERZ98139.1 - 2.3 8.7 9.4 3.9 7.9 4.1 2.6 2 1 0 2 2 2 0 PhoU domain DUF342 PF03961.8 ERZ98139.1 - 2.5 6.4 21.0 0.14 10.5 9.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Fib_alpha PF08702.5 ERZ98139.1 - 2.7 8.1 14.7 0.81 9.7 5.9 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.15 ERZ98139.1 - 2.9 7.6 25.4 0.41 10.4 5.7 3.2 2 1 1 3 3 2 0 Prefoldin subunit DUF3373 PF11853.3 ERZ98139.1 - 3.1 6.2 11.3 2.2 6.6 6.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3373) ORF6C PF10552.4 ERZ98139.1 - 3.1 7.5 21.2 0.98 9.1 2.6 3.7 2 1 2 4 4 3 0 ORF6C domain Hormone_1 PF00103.15 ERZ98139.1 - 3.1 7.0 9.5 1.9 7.7 3.7 2.3 2 1 0 2 2 2 0 Somatotropin hormone family DUF2203 PF09969.4 ERZ98139.1 - 3.3 7.9 8.5 1.7 8.8 3.8 2.1 1 1 1 2 2 1 0 Uncharacterized conserved protein (DUF2203) Nsp1_C PF05064.8 ERZ98139.1 - 3.4 7.3 11.5 3.6 7.2 6.0 2.4 2 1 1 3 3 2 0 Nsp1-like C-terminal region Prefoldin PF02996.12 ERZ98139.1 - 3.4 7.3 17.8 0.29 10.7 2.8 3.3 2 1 1 3 3 2 0 Prefoldin subunit TSC22 PF01166.13 ERZ98139.1 - 3.4 7.6 16.8 0.2 11.6 0.5 3.4 2 1 1 3 3 2 0 TSC-22/dip/bun family MerR-DNA-bind PF09278.6 ERZ98139.1 - 3.5 8.1 6.3 16 5.9 2.6 2.9 1 1 1 2 2 2 0 MerR, DNA binding Fzo_mitofusin PF04799.8 ERZ98139.1 - 3.7 6.9 14.5 3.2 7.0 6.3 2.8 2 1 1 3 3 3 0 fzo-like conserved region Uds1 PF15456.1 ERZ98139.1 - 3.8 7.5 11.5 6 6.8 1.9 2.4 1 1 1 2 2 2 0 Up-regulated During Septation AKNA PF12443.3 ERZ98139.1 - 4.4 7.3 11.8 5.9 6.9 3.8 2.9 2 1 1 3 3 2 0 AT-hook-containing transcription factor CR6_interact PF10147.4 ERZ98139.1 - 4.4 6.5 16.9 2 7.7 7.6 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Sec20 PF03908.8 ERZ98139.1 - 4.4 7.0 7.2 2.1 8.1 2.2 2.3 2 2 0 2 2 1 0 Sec20 Phasin PF05597.6 ERZ98139.1 - 4.7 6.9 14.5 12 5.6 8.7 2.7 2 1 0 2 2 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CCDC-167 PF15188.1 ERZ98139.1 - 5.2 7.0 19.4 0.37 10.7 8.7 2.6 2 2 0 2 2 1 0 Coiled-coil domain-containing protein 167 bZIP_2 PF07716.10 ERZ98139.1 - 5.6 6.8 12.5 1.5 8.6 1.7 3.1 1 1 1 2 2 2 0 Basic region leucine zipper DUF4337 PF14235.1 ERZ98139.1 - 6.2 6.6 9.3 2.2 8.0 4.4 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4337) TMF_TATA_bd PF12325.3 ERZ98139.1 - 6.4 6.5 18.1 3.6 7.3 9.7 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.1 ERZ98139.1 - 7.4 6.5 12.9 4.4 7.3 3.6 3.0 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DivIVA PF05103.8 ERZ98139.1 - 7.6 6.5 18.9 0.33 10.9 6.1 2.9 2 2 1 3 3 2 0 DivIVA protein DUF724 PF05266.9 ERZ98139.1 - 7.7 6.0 18.8 3.7 7.1 10.5 2.2 2 1 1 3 3 2 0 Protein of unknown function (DUF724) Syntaxin PF00804.20 ERZ98139.1 - 7.9 6.7 16.8 1e+02 3.1 11.6 2.9 1 1 0 1 1 1 0 Syntaxin DUF2205 PF10224.4 ERZ98139.1 - 8.5 6.0 16.9 2.2 7.9 7.7 2.5 2 1 1 3 3 2 0 Predicted coiled-coil protein (DUF2205) Dimer_Tnp_hAT PF05699.9 ERZ98141.1 - 3.9e-17 61.6 0.0 4.1e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RNase_H PF00075.19 ERZ98143.1 - 4e-12 46.6 0.0 5.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 RNase H CR6_interact PF10147.4 ERZ98144.1 - 0.012 14.9 0.4 0.019 14.2 0.0 1.5 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Snapin_Pallidin PF14712.1 ERZ98144.1 - 0.081 13.2 1.0 0.17 12.2 0.2 1.9 2 0 0 2 2 2 0 Snapin/Pallidin TrbM PF07424.6 ERZ98144.1 - 0.085 12.8 1.3 0.11 12.4 0.9 1.2 1 0 0 1 1 1 0 TrbM Mmp37 PF09139.6 ERZ98144.1 - 0.09 11.7 3.2 0.12 11.3 2.2 1.1 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 Rota_NSP4 PF01452.11 ERZ98144.1 - 0.11 11.8 1.5 0.16 11.2 1.0 1.3 1 0 0 1 1 1 0 Rotavirus non structural protein LSM14 PF12701.2 ERZ98145.1 - 7.4e-37 125.0 0.4 2.7e-36 123.2 0.0 2.2 2 0 0 2 2 2 1 Scd6-like Sm domain FDF PF09532.5 ERZ98145.1 - 8.1e-20 71.3 5.5 8.1e-20 71.3 3.8 3.2 2 1 1 3 3 3 1 FDF domain SM-ATX PF14438.1 ERZ98145.1 - 4.5e-07 29.6 0.2 5.1e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Ataxin 2 SM domain GRP PF07172.6 ERZ98145.1 - 7.1 7.1 22.5 1.1 9.7 9.2 3.1 3 0 0 3 3 3 0 Glycine rich protein family TLD PF07534.11 ERZ98146.1 - 2.5e-09 37.2 0.1 4.1e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 TLD DapH_N PF08503.5 ERZ98147.1 - 0.05 13.7 0.7 5.1 7.2 0.0 3.0 2 1 0 2 2 2 0 Tetrahydrodipicolinate succinyltransferase N-terminal TLD PF07534.11 ERZ98148.1 - 1.1e-12 48.1 0.5 1.9e-12 47.3 0.2 1.5 2 0 0 2 2 2 1 TLD ZZ PF00569.12 ERZ98148.1 - 2.4e-07 30.1 25.4 9.6e-07 28.2 8.1 2.3 2 0 0 2 2 2 2 Zinc finger, ZZ type DUF2577 PF10844.3 ERZ98151.1 - 0.0079 16.2 1.2 3.1 7.9 0.1 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2577) MCC-bdg_PDZ PF10506.4 ERZ98151.1 - 0.072 12.9 1.7 0.081 12.7 0.2 1.9 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome E1_DerP2_DerF2 PF02221.10 ERZ98152.1 - 8.4e-11 42.2 0.4 9.6e-11 42.0 0.3 1.0 1 0 0 1 1 1 1 ML domain Kelch_6 PF13964.1 ERZ98153.1 - 1.5e-16 59.7 14.8 0.0002 21.3 0.0 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 ERZ98153.1 - 3.7e-16 58.6 7.6 0.015 15.2 0.0 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ERZ98153.1 - 6.2e-16 57.9 18.8 5.8e-06 25.9 0.0 6.2 5 2 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ98153.1 - 2.7e-15 56.0 12.2 0.0014 18.7 0.3 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ERZ98153.1 - 2.4e-08 33.3 14.5 0.053 13.0 0.6 5.8 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ERZ98153.1 - 6.6e-05 22.5 6.3 0.085 12.6 0.0 5.2 6 1 0 6 6 6 2 Kelch motif Retrotrans_gag PF03732.12 ERZ98154.1 - 2.2e-09 37.2 0.2 2.2e-09 37.2 0.1 2.8 3 0 0 3 3 3 1 Retrotransposon gag protein Zn_ribbon_2 PF12674.2 ERZ98154.1 - 0.05 13.9 0.4 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Putative zinc ribbon domain Mesd PF10185.4 ERZ98155.1 - 0.76 9.4 3.9 0.95 9.1 1.6 1.7 1 1 1 2 2 2 0 Chaperone for wingless signalling and trafficking of LDL receptor TSC22 PF01166.13 ERZ98158.1 - 2.5e-05 24.1 4.2 2.6e-05 24.1 2.9 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF972 PF06156.8 ERZ98158.1 - 0.006 16.9 3.2 0.0065 16.8 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF972) DivIC PF04977.10 ERZ98158.1 - 0.0083 15.5 5.5 0.0089 15.4 3.8 1.1 1 0 0 1 1 1 1 Septum formation initiator Shugoshin_N PF07558.6 ERZ98158.1 - 0.0084 15.8 0.9 0.016 14.8 0.4 1.6 1 1 1 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF4239 PF14023.1 ERZ98158.1 - 0.0099 15.2 0.8 0.01 15.1 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4239) ATG16 PF08614.6 ERZ98158.1 - 0.023 14.4 3.7 0.026 14.3 2.6 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 ERZ98158.1 - 0.047 13.6 3.1 0.059 13.3 2.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor M PF02370.11 ERZ98158.1 - 0.089 13.1 5.7 0.12 12.8 3.1 1.9 1 1 0 1 1 1 0 M protein repeat HALZ PF02183.13 ERZ98158.1 - 0.11 12.2 2.6 0.14 11.9 1.8 1.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper Ax_dynein_light PF10211.4 ERZ98158.1 - 0.14 11.9 4.6 0.14 11.9 3.2 1.0 1 0 0 1 1 1 0 Axonemal dynein light chain DUF287 PF03384.9 ERZ98158.1 - 0.16 12.1 2.5 0.14 12.3 0.7 1.7 1 1 1 2 2 2 0 Drosophila protein of unknown function, DUF287 bZIP_2 PF07716.10 ERZ98158.1 - 0.34 10.7 7.1 0.14 12.0 3.3 1.8 1 1 0 1 1 1 0 Basic region leucine zipper CENP-H PF05837.7 ERZ98158.1 - 0.38 10.9 3.8 0.37 10.9 2.7 1.0 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF904 PF06005.7 ERZ98158.1 - 0.45 10.8 7.3 0.58 10.4 5.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF904) ATP-synt_E_2 PF08112.6 ERZ98158.1 - 0.73 9.9 3.3 5.3 7.1 0.5 2.1 1 1 1 2 2 2 0 ATP synthase epsilon subunit Pox_A_type_inc PF04508.7 ERZ98158.1 - 3.2 7.7 6.1 1.5 8.8 0.3 2.8 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat zf-RVT PF13966.1 ERZ98159.1 - 0.033 14.4 2.8 0.069 13.4 1.4 2.0 1 1 0 1 1 1 0 zinc-binding in reverse transcriptase Uma2 PF05685.7 ERZ98161.1 - 2.1e-11 43.4 0.0 2.4e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease FlaC_arch PF05377.6 ERZ98163.1 - 0.00066 19.5 1.1 0.00066 19.5 0.7 2.5 3 0 0 3 3 3 1 Flagella accessory protein C (FlaC) DUF972 PF06156.8 ERZ98163.1 - 0.0014 18.9 0.3 0.0014 18.9 0.2 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 ERZ98163.1 - 0.0015 18.2 0.6 0.0031 17.2 0.2 1.6 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein Spc7 PF08317.6 ERZ98163.1 - 0.0061 15.2 3.0 0.0061 15.2 2.1 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein NPV_P10 PF05531.7 ERZ98163.1 - 0.0079 16.4 1.9 0.047 13.9 0.1 2.6 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 ERZ98163.1 - 0.01 15.0 0.2 0.012 14.8 0.1 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein phiKZ_IP PF12699.2 ERZ98163.1 - 0.011 14.7 1.2 0.016 14.1 0.1 1.8 2 0 0 2 2 2 0 phiKZ-like phage internal head proteins BicD PF09730.4 ERZ98163.1 - 0.011 14.1 4.4 0.013 13.9 3.0 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D DASH_Duo1 PF08651.5 ERZ98163.1 - 0.013 15.0 0.4 0.048 13.2 0.2 2.0 2 0 0 2 2 2 0 DASH complex subunit Duo1 AKNA PF12443.3 ERZ98163.1 - 0.028 14.4 1.1 0.06 13.3 0.1 1.9 2 0 0 2 2 2 0 AT-hook-containing transcription factor CCDC-167 PF15188.1 ERZ98163.1 - 0.031 14.2 0.4 0.031 14.2 0.3 2.7 3 2 0 3 3 2 0 Coiled-coil domain-containing protein 167 YqaJ PF09588.5 ERZ98163.1 - 0.037 13.9 0.5 0.075 12.9 0.2 1.6 1 1 1 2 2 2 0 YqaJ-like viral recombinase domain DivIC PF04977.10 ERZ98163.1 - 0.04 13.3 0.6 0.04 13.3 0.4 2.3 3 1 0 3 3 2 0 Septum formation initiator IncA PF04156.9 ERZ98163.1 - 0.062 12.8 2.7 0.049 13.2 0.3 1.8 1 1 1 2 2 1 0 IncA protein Circo_capsid PF02443.10 ERZ98163.1 - 0.065 12.5 1.3 0.21 10.9 0.2 2.0 1 1 1 2 2 2 0 Circovirus capsid protein Spectrin PF00435.16 ERZ98163.1 - 0.073 13.3 0.6 0.21 11.9 0.4 1.8 1 0 0 1 1 1 0 Spectrin repeat DUF948 PF06103.6 ERZ98163.1 - 0.16 11.8 2.3 0.17 11.7 0.1 2.1 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.3 ERZ98163.1 - 0.18 11.5 4.1 0.13 11.9 0.2 2.3 3 0 0 3 3 2 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.6 ERZ98163.1 - 0.41 10.4 5.0 0.088 12.6 1.1 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.7 ERZ98163.1 - 0.49 10.2 4.2 0.17 11.6 1.0 1.7 2 1 0 2 2 1 0 Protein of unknown function (DUF1664) bZIP_2 PF07716.10 ERZ98163.1 - 0.52 10.1 2.8 0.57 10.0 0.2 2.3 2 1 0 2 2 2 0 Basic region leucine zipper DUF342 PF03961.8 ERZ98163.1 - 0.53 8.6 8.8 0.053 11.9 2.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Phage_GP20 PF06810.6 ERZ98163.1 - 1 8.7 8.7 0.2 11.0 1.1 2.7 2 1 0 3 3 3 0 Phage minor structural protein GP20 Med9 PF07544.8 ERZ98163.1 - 1.1 9.0 5.2 0.33 10.7 1.2 2.0 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 CENP-F_leu_zip PF10473.4 ERZ98163.1 - 1.3 8.9 10.0 0.37 10.6 1.9 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSC22 PF01166.13 ERZ98163.1 - 1.4 8.9 5.9 0.53 10.2 0.4 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family Laminin_II PF06009.7 ERZ98163.1 - 1.6 8.5 6.7 0.41 10.4 1.9 2.1 2 1 0 2 2 2 0 Laminin Domain II bZIP_1 PF00170.16 ERZ98163.1 - 1.6 8.7 6.0 1.4 8.9 1.2 2.7 2 1 1 3 3 3 0 bZIP transcription factor TBPIP PF07106.8 ERZ98163.1 - 1.6 8.2 10.7 0.35 10.4 3.4 2.5 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_DNA_bd PF12329.3 ERZ98163.1 - 2.7 7.8 8.5 1 9.2 1.6 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ORF6C PF10552.4 ERZ98163.1 - 2.7 7.7 6.7 5.9 6.6 2.2 2.9 2 1 0 2 2 2 0 ORF6C domain DUF904 PF06005.7 ERZ98163.1 - 2.8 8.3 9.1 0.33 11.2 1.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF904) Prominin PF05478.6 ERZ98163.1 - 2.8 5.3 7.5 1.4 6.3 0.4 2.0 1 1 1 2 2 2 0 Prominin Prefoldin_2 PF01920.15 ERZ98163.1 - 3.1 7.5 9.0 0.85 9.4 1.1 2.8 3 0 0 3 3 3 0 Prefoldin subunit Syntaxin PF00804.20 ERZ98163.1 - 5.4 7.2 10.3 3.1 8.0 3.7 2.8 1 1 1 2 2 2 0 Syntaxin BLOC1_2 PF10046.4 ERZ98163.1 - 6.2 7.0 9.9 7.8 6.7 3.7 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4482 PF14818.1 ERZ98163.1 - 9.7 6.8 7.8 10 6.7 0.5 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4482) CorA PF01544.13 ERZ98164.1 - 0.025 13.6 0.6 0.028 13.4 0.4 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Transglut_i_TM PF14400.1 ERZ98164.1 - 0.051 13.0 0.3 0.062 12.8 0.2 1.1 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices Filo_VP35 PF02097.10 ERZ98164.1 - 0.077 12.1 0.2 0.084 12.0 0.1 1.0 1 0 0 1 1 1 0 Filoviridae VP35 Wbp11 PF09429.5 ERZ98164.1 - 0.1 12.5 7.5 0.15 12.0 5.2 1.3 1 0 0 1 1 1 0 WW domain binding protein 11 RabGAP-TBC PF00566.13 ERZ98164.1 - 0.12 11.8 2.4 0.15 11.4 1.7 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Prominin PF05478.6 ERZ98164.1 - 0.15 9.5 2.9 0.18 9.2 2.0 1.0 1 0 0 1 1 1 0 Prominin DUF1053 PF06327.9 ERZ98164.1 - 0.18 12.1 2.2 0.2 11.9 1.2 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1053) APG17 PF04108.7 ERZ98165.1 - 6.6e-48 163.5 26.5 1.2e-47 162.6 18.4 1.4 1 1 0 1 1 1 1 Autophagy protein Apg17 LAGLIDADG_3 PF14528.1 ERZ98165.1 - 0.21 11.8 1.8 1.9 8.8 0.1 2.9 2 1 0 2 2 2 0 LAGLIDADG-like domain DUF1759 PF03564.10 ERZ98165.1 - 5.8 6.7 16.7 1.6 8.5 0.2 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1759) NPV_P10 PF05531.7 ERZ98165.1 - 8.5 6.7 12.0 14 6.0 1.0 3.6 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF357 PF04010.8 ERZ98167.1 - 0.39 10.4 2.0 19 5.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF357) RNA_pol_Rpb1_6 PF04992.9 ERZ98168.1 - 0.087 12.5 0.2 0.095 12.4 0.2 1.2 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 6 zf-BED PF02892.10 ERZ98173.1 - 0.012 15.3 0.2 0.031 14.0 0.2 1.7 1 0 0 1 1 1 0 BED zinc finger Ribosomal_L24e PF01246.15 ERZ98174.1 - 6e-31 106.1 0.6 6e-31 106.1 0.4 2.6 2 1 1 3 3 3 1 Ribosomal protein L24e DUF4361 PF14274.1 ERZ98174.1 - 0.19 11.3 1.0 0.3 10.7 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4361) PVL_ORF50 PF07768.6 ERZ98174.1 - 0.89 9.5 9.8 1.4 8.9 6.8 1.3 1 0 0 1 1 1 0 PVL ORF-50-like family COX16 PF14138.1 ERZ98174.1 - 3.2 7.9 11.1 0.25 11.5 0.9 2.8 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Asp-B-Hydro_N PF05279.6 ERZ98174.1 - 3.7 7.3 11.2 4.4 7.0 7.7 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region LMBR1 PF04791.11 ERZ98174.1 - 5.1 5.5 5.0 6.2 5.2 3.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein D5_N PF08706.6 ERZ98174.1 - 6.6 6.8 8.5 20 5.2 5.9 1.8 1 1 0 1 1 1 0 D5 N terminal like AAA_23 PF13476.1 ERZ98175.1 - 1.7e-21 77.5 0.0 2e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 ERZ98175.1 - 9.6e-09 34.7 0.0 1e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.14 ERZ98175.1 - 1.7e-07 30.7 0.0 2.4e-07 30.1 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ERZ98175.1 - 2.1e-06 27.1 0.0 4.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 ERZ98175.1 - 1.1e-05 25.5 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ERZ98175.1 - 0.0016 18.7 0.5 0.0028 17.9 0.4 1.5 1 1 0 1 1 1 1 ABC transporter MobB PF03205.9 ERZ98175.1 - 0.0089 15.7 0.3 0.018 14.7 0.1 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ERZ98175.1 - 0.0098 15.6 0.1 0.023 14.4 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_13 PF13166.1 ERZ98175.1 - 0.012 14.1 0.0 0.012 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ98175.1 - 0.013 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.1 ERZ98175.1 - 0.014 15.3 0.3 0.022 14.7 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ERZ98175.1 - 0.018 15.0 0.0 0.04 13.9 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 ERZ98175.1 - 0.019 15.7 0.4 0.026 15.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 ERZ98175.1 - 0.024 15.1 0.0 0.037 14.5 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_18 PF13238.1 ERZ98175.1 - 0.026 14.8 0.1 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 ERZ98175.1 - 0.033 11.5 0.0 0.046 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ABC_ATPase PF09818.4 ERZ98175.1 - 0.036 12.6 0.4 0.058 11.9 0.0 1.4 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF258 PF03193.11 ERZ98175.1 - 0.043 13.0 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 ERZ98175.1 - 0.048 13.7 0.2 0.1 12.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ERZ98175.1 - 0.063 13.1 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 ERZ98175.1 - 0.069 11.7 0.2 0.11 11.1 0.0 1.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.17 ERZ98175.1 - 0.088 12.2 0.2 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain cobW PF02492.14 ERZ98175.1 - 0.11 11.9 0.3 0.2 11.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 ERZ98175.1 - 0.13 11.8 0.1 0.23 11.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ERZ98175.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.24 ERZ98175.1 - 0.16 12.1 0.9 0.52 10.5 0.6 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad50_zn_hook PF04423.9 ERZ98176.1 - 2.6e-09 36.4 0.5 3e-09 36.2 0.3 1.1 1 0 0 1 1 1 1 Rad50 zinc hook motif DUF2256 PF10013.4 ERZ98176.1 - 0.011 15.5 0.1 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Prok-RING_4 PF14447.1 ERZ98176.1 - 0.091 12.3 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 HMG_box PF00505.14 ERZ98180.1 - 2.5e-18 66.1 2.4 3e-18 65.8 1.7 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box UPF0154 PF03672.8 ERZ98180.1 - 0.0081 15.7 0.1 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) HMG_box_2 PF09011.5 ERZ98180.1 - 0.77 10.1 5.0 0.095 13.0 1.0 1.3 2 0 0 2 2 2 0 HMG-box domain zinc-ribbons_6 PF07191.7 ERZ98183.1 - 0.0039 16.9 2.9 0.0055 16.4 1.3 1.9 1 1 1 2 2 2 1 zinc-ribbons Sel1 PF08238.7 ERZ98183.1 - 0.034 14.7 0.7 0.034 14.7 0.5 1.9 2 1 0 2 2 2 0 Sel1 repeat DUF2616 PF11077.3 ERZ98183.1 - 0.044 13.2 2.0 0.043 13.3 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) zf-C4_ClpX PF06689.8 ERZ98183.1 - 0.34 10.4 3.3 1.4 8.4 0.2 2.2 2 0 0 2 2 2 0 ClpX C4-type zinc finger Lactamase_B_2 PF12706.2 ERZ98185.1 - 0.029 13.9 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Stomoxyn PF11585.3 ERZ98185.1 - 0.086 12.6 0.2 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn DUF4357 PF14267.1 ERZ98186.1 - 0.064 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) Glyco_hydro_53 PF07745.8 ERZ98186.1 - 0.086 11.6 0.1 0.18 10.5 0.1 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 53 Sel1 PF08238.7 ERZ98187.1 - 1.2e-45 152.9 13.7 1.4e-11 44.6 0.0 4.1 4 0 0 4 4 4 4 Sel1 repeat MIT PF04212.13 ERZ98187.1 - 0.00024 20.9 7.2 0.25 11.2 0.1 4.0 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ERZ98187.1 - 0.0054 17.0 4.9 2.8 8.6 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Acid_phosphat_B PF03767.9 ERZ98187.1 - 0.0066 15.8 1.0 0.33 10.2 0.0 2.7 1 1 1 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Peptidase_C14 PF00656.17 ERZ98187.1 - 0.017 14.8 0.0 0.092 12.4 0.0 2.0 1 1 1 2 2 2 0 Caspase domain Prenyltrans_1 PF13243.1 ERZ98187.1 - 0.018 15.0 2.7 1.9 8.5 0.1 2.5 1 1 1 2 2 2 0 Prenyltransferase-like Leuk-A4-hydro_C PF09127.6 ERZ98187.1 - 0.028 14.0 1.4 2.2 7.9 0.1 2.5 1 1 1 2 2 2 0 Leukotriene A4 hydrolase, C-terminal Prenyltrans_2 PF13249.1 ERZ98187.1 - 0.029 14.7 1.3 10 6.5 0.2 2.7 1 1 1 2 2 2 0 Prenyltransferase-like TPR_20 PF14561.1 ERZ98187.1 - 0.034 14.2 1.1 2.8 8.1 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4041 PF13250.1 ERZ98187.1 - 0.04 13.4 0.3 10 5.7 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4041) NUMOD1 PF07453.8 ERZ98187.1 - 0.045 13.6 0.3 48 4.0 0.0 3.8 4 0 0 4 4 4 0 NUMOD1 domain zf-GRF PF06839.7 ERZ98187.1 - 0.14 12.1 6.5 2.3 8.1 0.1 3.4 4 0 0 4 4 4 0 GRF zinc finger HTH_16 PF12645.2 ERZ98187.1 - 0.14 12.1 2.9 9.5 6.2 0.0 3.4 4 0 0 4 4 4 0 Helix-turn-helix domain CN_hydrolase PF00795.17 ERZ98187.1 - 0.18 11.1 0.5 0.81 9.0 0.4 2.2 1 1 0 1 1 1 0 Carbon-nitrogen hydrolase TPR_2 PF07719.12 ERZ98187.1 - 0.48 10.4 16.2 13 5.9 0.2 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 ERZ98187.1 - 1.4 9.0 7.2 29 4.8 0.1 3.4 2 1 2 4 4 4 0 Rapamycin binding domain TPR_1 PF00515.23 ERZ98187.1 - 5.6 6.7 19.9 15 5.3 0.1 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat PDR_assoc PF08370.6 ERZ98190.1 - 0.052 13.0 0.7 0.12 11.9 0.5 1.6 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF1129 PF06570.6 ERZ98190.1 - 0.27 10.5 3.1 0.42 9.8 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) PDR_assoc PF08370.6 ERZ98191.1 - 0.11 12.0 1.6 0.23 10.9 1.1 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated Ion_trans PF00520.26 ERZ98193.1 - 1.8e-07 30.6 13.2 2.2e-07 30.3 8.5 1.7 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 ERZ98193.1 - 0.094 11.1 16.6 0.059 11.7 8.5 2.2 2 0 0 2 2 2 0 Polycystin cation channel Adaptin_N PF01602.15 ERZ98196.1 - 9.3e-69 232.1 11.5 1.1e-68 231.8 8.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.17 ERZ98196.1 - 3.5e-09 35.9 1.2 0.68 10.1 0.0 5.4 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.2 ERZ98196.1 - 2.2e-08 34.1 9.6 1.7e-07 31.2 3.6 3.3 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ERZ98196.1 - 2.2e-08 34.2 0.0 0.013 15.7 0.0 3.9 3 2 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 ERZ98196.1 - 4.4e-05 23.8 0.1 0.86 10.1 0.0 3.9 4 1 1 5 5 5 2 HEAT-like repeat Dopey_N PF04118.9 ERZ98196.1 - 0.005 15.6 4.7 0.0084 14.9 0.9 2.5 1 1 1 2 2 2 1 Dopey, N-terminal DUF3361 PF11841.3 ERZ98196.1 - 0.0078 15.9 0.2 0.27 10.9 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) Ribosomal_S17e PF00833.13 ERZ98196.1 - 0.023 14.4 0.4 0.051 13.3 0.3 1.5 1 0 0 1 1 1 0 Ribosomal S17 DUF2435 PF10363.4 ERZ98196.1 - 0.043 13.7 2.0 32 4.5 0.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2435) RRF PF01765.14 ERZ98197.1 - 6.4e-46 155.8 10.7 6.4e-46 155.8 7.4 1.7 2 0 0 2 2 2 1 Ribosome recycling factor ATP-synt_B PF00430.13 ERZ98197.1 - 3.3 7.5 9.3 0.32 10.8 0.9 2.4 2 1 0 2 2 2 0 ATP synthase B/B' CF(0) Peptidase_C65 PF10275.4 ERZ98198.1 - 1.4e-65 221.0 1.7 2.2e-65 220.4 1.2 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 ERZ98198.1 - 8.5e-12 45.7 1.0 4.9e-06 27.1 0.0 2.8 2 2 1 3 3 3 2 OTU-like cysteine protease POX PF07526.6 ERZ98198.1 - 3.8 7.7 6.3 20 5.3 4.4 2.1 1 1 0 1 1 1 0 Associated with HOX Ndc1_Nup PF09531.5 ERZ98198.1 - 4.2 5.6 7.9 5.8 5.2 5.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BTB PF00651.26 ERZ98199.1 - 3.6e-20 72.0 0.4 1.3e-19 70.2 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ98199.1 - 7.2e-08 32.5 5.2 1.8e-07 31.2 3.6 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ98199.1 - 7.6e-06 25.7 1.3 6.4e-05 22.7 0.1 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ98200.1 - 6.1e-21 74.4 0.8 1.6e-20 73.1 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ98200.1 - 1.8e-11 44.2 6.0 3.3e-10 40.0 3.0 2.5 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ98200.1 - 1.3e-05 24.9 3.7 0.00011 22.0 0.1 3.2 3 1 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ98200.1 - 0.013 14.6 0.6 0.02 14.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB PF00651.26 ERZ98201.1 - 8.2e-21 74.0 0.8 1.9e-20 72.8 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ98201.1 - 1.9e-12 47.3 6.0 3e-11 43.4 2.8 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ98201.1 - 1.3e-07 31.4 1.7 5.9e-06 26.0 0.1 3.3 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ98201.1 - 0.0094 15.1 0.5 0.015 14.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) DDE_3 PF13358.1 ERZ98203.1 - 0.13 12.0 0.1 0.14 11.8 0.1 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease LRR_4 PF12799.2 ERZ98204.1 - 2.9e-10 39.5 21.7 0.00031 20.2 0.8 5.7 2 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ98204.1 - 5.4e-05 22.8 18.3 0.39 10.5 2.8 5.0 2 1 0 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 ERZ98204.1 - 0.0089 16.0 16.5 14 6.3 0.1 7.5 5 3 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 ERZ98204.1 - 0.011 15.6 20.9 9.4 6.7 0.9 7.4 5 2 1 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.1 ERZ98204.1 - 0.59 10.3 21.6 2.3 8.5 0.1 6.6 5 2 2 7 7 7 0 Leucine Rich repeat LRR_5 PF13306.1 ERZ98204.1 - 0.9 9.2 4.9 0.68 9.6 0.4 2.4 1 1 2 3 3 3 0 Leucine rich repeats (6 copies) RloB PF13707.1 ERZ98205.1 - 0.0079 15.8 2.2 0.0095 15.6 1.5 1.3 1 0 0 1 1 1 1 RloB-like protein DUF2179 PF10035.4 ERZ98205.1 - 0.086 12.4 0.2 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) Transferase PF02458.10 ERZ98208.1 - 0.023 13.1 0.1 0.59 8.5 0.0 2.0 2 0 0 2 2 2 0 Transferase family Cyc-maltodext_C PF10438.4 ERZ98208.1 - 0.059 13.4 0.4 0.14 12.2 0.3 1.5 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain Med28 PF11594.3 ERZ98208.1 - 0.69 10.1 3.5 3.7 7.8 0.4 2.2 2 0 0 2 2 2 0 Mediator complex subunit 28 APG12 PF04110.8 ERZ98209.1 - 0.093 12.9 0.1 0.35 11.0 0.0 1.9 1 1 1 2 2 2 0 Ubiquitin-like autophagy protein Apg12 DUF2435 PF10363.4 ERZ98211.1 - 1.5e-09 37.5 3.3 3.7e-09 36.3 0.2 3.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) PipA PF07108.6 ERZ98213.1 - 0.074 12.4 0.4 0.49 9.7 0.0 2.3 2 1 1 3 3 3 0 PipA protein Pkinase_Tyr PF07714.12 ERZ98214.1 - 2.9e-10 39.6 0.0 3e-05 23.2 0.1 2.8 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ98214.1 - 7.3e-06 25.3 0.0 0.065 12.3 0.0 3.0 1 1 2 3 3 3 3 Protein kinase domain Dimer_Tnp_hAT PF05699.9 ERZ98217.1 - 3.5e-15 55.3 0.0 4.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region 6PF2K PF01591.13 ERZ98218.1 - 0.021 13.9 1.3 0.023 13.7 0.9 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Peptidase_M17_N PF02789.12 ERZ98219.1 - 1.1e-17 63.9 0.7 1.6e-17 63.4 0.5 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.16 ERZ98219.1 - 7.6e-17 61.1 0.0 1.1e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain IlvN PF07991.7 ERZ98219.1 - 0.057 12.7 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain MULE PF10551.4 ERZ98221.1 - 2e-06 27.8 0.0 3.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 MULE transposase domain S1FA PF04689.8 ERZ98221.1 - 0.027 14.3 0.4 0.043 13.6 0.3 1.3 1 0 0 1 1 1 0 DNA binding protein S1FA Z1 PF10593.4 ERZ98222.1 - 0.091 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Z1 domain Pkinase PF00069.20 ERZ98223.1 - 6.3e-85 284.4 1.9 1.7e-44 151.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98223.1 - 1.7e-68 230.5 0.0 1.6e-35 122.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 ERZ98223.1 - 1.4e-06 27.7 0.1 0.0055 16.0 0.0 3.0 3 0 0 3 3 3 2 RIO1 family APH PF01636.18 ERZ98223.1 - 3.5e-06 26.9 0.1 0.017 14.8 0.0 2.7 2 1 0 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 ERZ98223.1 - 0.0022 17.0 0.0 0.58 9.1 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_Helicase PF02689.9 ERZ98225.1 - 6.9e-06 24.1 0.1 7.1e-06 24.0 0.1 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ERZ98225.1 - 0.011 15.9 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 ERZ98225.1 - 0.083 12.3 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PGAMP PF07644.6 ERZ98225.1 - 0.38 10.5 1.8 8.4 6.2 0.3 2.4 2 0 0 2 2 2 0 Planctomycete PGAMP RNA_pol_Rpb1_5 PF04998.12 ERZ98226.1 - 0.15 11.2 0.1 0.15 11.2 0.0 2.1 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 5 Rib_5-P_isom_A PF06026.9 ERZ98227.1 - 5.8e-60 201.5 0.0 7.5e-60 201.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 ERZ98227.1 - 0.045 13.3 0.1 2.2 7.9 0.1 2.1 2 0 0 2 2 2 0 DeoR C terminal sensor domain WD40 PF00400.27 ERZ98228.1 - 3.5e-31 105.9 13.0 7.3e-09 35.1 0.6 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat LisH PF08513.6 ERZ98228.1 - 0.001 18.7 0.0 0.0061 16.2 0.1 2.2 2 0 0 2 2 2 1 LisH Ras PF00071.17 ERZ98229.1 - 7.9e-38 129.3 0.0 1e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ98229.1 - 1.5e-09 38.3 0.0 4.9e-09 36.7 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein HTH_Tnp_Tc5 PF03221.11 ERZ98231.1 - 3.7e-05 23.4 1.6 0.00038 20.2 1.1 2.3 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain DnaB PF00772.16 ERZ98231.1 - 0.072 12.9 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain DDE_1 PF03184.14 ERZ98232.1 - 9.3e-17 60.8 0.0 9.5e-17 60.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease AIG1 PF04548.11 ERZ98233.1 - 1.8e-27 95.8 0.0 2.2e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ERZ98233.1 - 1.8e-11 43.9 0.0 2.7e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ERZ98233.1 - 1.6e-05 25.0 0.0 2.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ERZ98233.1 - 8e-05 21.8 0.0 0.00014 21.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SRPRB PF09439.5 ERZ98233.1 - 9.3e-05 21.7 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 ERZ98233.1 - 0.00014 21.1 0.0 0.00022 20.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.22 ERZ98233.1 - 0.00024 21.4 0.3 0.00068 19.9 0.1 1.4 1 1 0 1 1 1 1 ABC transporter Dynamin_N PF00350.18 ERZ98233.1 - 0.00024 20.9 0.9 0.43 10.3 0.0 2.3 2 0 0 2 2 2 2 Dynamin family AAA_29 PF13555.1 ERZ98233.1 - 0.0015 18.0 0.1 0.0029 17.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 ERZ98233.1 - 0.0025 18.1 0.0 0.0041 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ERZ98233.1 - 0.0032 16.4 0.1 0.0078 15.1 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein Gtr1_RagA PF04670.7 ERZ98233.1 - 0.0093 15.1 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ERZ98233.1 - 0.016 14.6 0.1 0.038 13.4 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_21 PF13304.1 ERZ98233.1 - 0.021 14.7 1.7 0.041 13.8 0.8 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.13 ERZ98233.1 - 0.022 13.7 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 Septin RNA_helicase PF00910.17 ERZ98233.1 - 0.023 14.8 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.1 ERZ98233.1 - 0.037 14.3 1.5 0.053 13.8 1.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ERZ98233.1 - 0.039 13.3 1.6 0.1 12.0 0.2 1.9 1 1 0 2 2 2 0 AAA-like domain AAA_16 PF13191.1 ERZ98233.1 - 0.04 13.9 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.4 ERZ98233.1 - 0.045 13.2 1.3 0.21 11.0 0.9 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 ERZ98233.1 - 0.058 14.2 0.7 0.11 13.3 0.5 1.6 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 ERZ98233.1 - 0.079 13.4 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein DUF815 PF05673.8 ERZ98233.1 - 0.1 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 ERZ98233.1 - 0.15 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family HxxPF_rpt PF13745.1 ERZ98235.1 - 0.043 14.1 0.0 0.051 13.8 0.0 1.1 1 0 0 1 1 1 0 HxxPF-repeated domain zf-RING_2 PF13639.1 ERZ98236.1 - 4.1e-09 36.1 9.8 4.1e-09 36.1 6.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 ERZ98236.1 - 2.8e-08 33.3 10.9 2.8e-08 33.3 7.5 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ERZ98236.1 - 4e-07 29.9 10.9 4e-07 29.9 7.5 2.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ98236.1 - 3.8e-06 26.5 10.1 3.8e-06 26.5 7.0 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ERZ98236.1 - 1.2e-05 24.8 11.4 1.2e-05 24.8 7.9 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ERZ98236.1 - 0.00062 19.8 8.1 0.00062 19.8 5.6 3.4 2 2 0 2 2 2 1 RING-H2 zinc finger zf-TRAF PF02176.13 ERZ98236.1 - 0.0014 19.0 20.9 0.0096 16.2 6.6 3.4 1 1 2 3 3 3 2 TRAF-type zinc finger zf-RING_6 PF14835.1 ERZ98236.1 - 0.002 17.8 4.2 0.0041 16.8 2.9 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 ERZ98236.1 - 0.024 14.4 6.7 0.024 14.4 4.7 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Sina PF03145.11 ERZ98236.1 - 0.36 10.4 17.0 0.04 13.5 3.5 2.9 1 1 2 3 3 3 0 Seven in absentia protein family zf-RING_UBOX PF13445.1 ERZ98236.1 - 2.1 8.1 16.7 0.44 10.3 1.7 3.0 3 0 0 3 3 3 0 RING-type zinc-finger zf-MIZ PF02891.15 ERZ98236.1 - 3.4 7.2 15.8 0.091 12.2 5.5 2.5 2 1 1 3 3 3 0 MIZ/SP-RING zinc finger Lipase_3 PF01764.20 ERZ98237.1 - 3.3e-23 81.8 0.0 5.2e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) MMR_HSR1 PF01926.18 ERZ98239.1 - 4.7e-06 26.5 1.5 6.6e-06 26.0 0.1 1.9 2 0 0 2 2 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 ERZ98239.1 - 0.00022 20.0 0.0 0.00031 19.5 0.0 1.4 1 0 0 1 1 1 1 G-protein alpha subunit DUF258 PF03193.11 ERZ98239.1 - 0.00074 18.7 1.5 0.0022 17.2 0.5 2.2 2 1 0 2 2 2 1 Protein of unknown function, DUF258 SRP54 PF00448.17 ERZ98239.1 - 0.0012 18.2 0.1 0.0042 16.5 0.1 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_28 PF13521.1 ERZ98239.1 - 0.0014 18.6 0.1 0.0085 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.11 ERZ98239.1 - 0.002 17.2 6.5 0.0053 15.9 2.4 2.5 2 1 0 2 2 2 1 AIG1 family AAA_23 PF13476.1 ERZ98239.1 - 0.0026 18.1 0.5 0.0026 18.1 0.4 2.5 1 1 0 2 2 2 1 AAA domain T2SE PF00437.15 ERZ98239.1 - 0.0044 15.9 0.2 0.012 14.4 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.1 ERZ98239.1 - 0.0044 16.5 0.1 0.01 15.3 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.18 ERZ98239.1 - 0.0083 15.9 1.6 2.1 8.1 0.1 2.7 1 1 1 2 2 2 2 Dynamin family GBP PF02263.14 ERZ98239.1 - 0.013 14.5 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain DUF815 PF05673.8 ERZ98239.1 - 0.018 13.9 0.2 0.042 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.24 ERZ98239.1 - 0.021 15.0 0.2 0.058 13.5 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IIGP PF05049.8 ERZ98239.1 - 0.031 13.1 0.3 1.9 7.2 0.1 2.3 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.22 ERZ98239.1 - 0.037 14.3 1.1 0.037 14.3 0.8 2.4 1 1 1 2 2 2 0 ABC transporter AAA_19 PF13245.1 ERZ98239.1 - 0.047 13.4 0.1 0.098 12.4 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain TrwB_AAD_bind PF10412.4 ERZ98239.1 - 0.069 11.7 0.1 0.11 11.0 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Miro PF08477.8 ERZ98239.1 - 0.08 13.4 0.4 0.32 11.4 0.1 2.2 2 1 0 2 2 2 0 Miro-like protein FtsK_SpoIIIE PF01580.13 ERZ98239.1 - 0.097 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF4083 PF13314.1 ERZ98241.1 - 0.021 14.6 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) LSR PF05624.9 ERZ98241.1 - 0.04 13.6 3.2 0.052 13.2 2.2 1.2 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) TMEM52 PF14979.1 ERZ98241.1 - 0.043 13.7 0.1 0.044 13.6 0.1 1.1 1 0 0 1 1 1 0 Transmembrane 52 DUF2985 PF11204.3 ERZ98241.1 - 0.06 13.1 0.2 0.075 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) Sigma_reg_N PF13800.1 ERZ98241.1 - 0.1 12.6 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Pkinase PF00069.20 ERZ98242.1 - 2.9e-11 43.0 0.5 3.2e-11 42.8 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98242.1 - 1.2e-09 37.6 0.1 1.3e-09 37.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3197 PF11432.3 ERZ98243.1 - 0.075 13.0 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) Rep_3 PF01051.16 ERZ98246.1 - 0.029 13.9 0.6 0.046 13.3 0.4 1.3 1 0 0 1 1 1 0 Initiator Replication protein UPF0118 PF01594.11 ERZ98246.1 - 0.13 11.1 1.4 0.19 10.6 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF20 RVT_1 PF00078.22 ERZ98247.1 - 0.0077 15.6 0.1 0.01 15.1 0.1 1.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S19 PF00203.16 ERZ98248.1 - 3.2e-35 119.6 0.5 5.2e-35 118.9 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.11 ERZ98248.1 - 0.0005 19.9 0.0 0.00071 19.4 0.0 1.2 1 0 0 1 1 1 1 Flagellar assembly protein FliH SbcD_C PF12320.3 ERZ98248.1 - 0.015 15.3 0.2 0.21 11.6 0.0 2.0 1 1 1 2 2 2 0 Type 5 capsule protein repressor C-terminal domain His_biosynth PF00977.16 ERZ98249.1 - 3.1e-46 157.4 0.0 1.7e-45 155.1 0.0 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 ERZ98249.1 - 2.4e-29 102.1 0.0 4.1e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.14 ERZ98249.1 - 3.8e-10 39.7 0.0 3.2e-09 36.6 0.0 2.1 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 ERZ98249.1 - 4.3e-09 36.1 0.0 1e-08 34.9 0.0 1.7 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.8 ERZ98249.1 - 0.008 15.6 0.0 0.13 11.7 0.0 2.2 1 1 0 1 1 1 1 Peptidase C26 Peptidase_S51 PF03575.12 ERZ98249.1 - 0.045 13.4 0.0 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S51 NMO PF03060.10 ERZ98249.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DUF3599 PF12206.3 ERZ98249.1 - 0.14 12.4 0.5 1.6 9.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3599) PSS PF03034.10 ERZ98250.1 - 3.2e-105 351.5 10.5 4.6e-105 351.0 7.2 1.2 1 0 0 1 1 1 1 Phosphatidyl serine synthase Abhydrolase_6 PF12697.2 ERZ98251.1 - 5.8e-31 108.1 0.0 8.7e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ98251.1 - 5.8e-22 78.3 0.0 8.5e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ERZ98251.1 - 5.2e-17 61.9 0.0 1.8e-16 60.2 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family DSPc PF00782.15 ERZ98251.1 - 7.9e-15 54.6 0.0 2.7e-14 52.8 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 ERZ98251.1 - 3.3e-06 27.2 0.3 0.00016 21.7 0.0 2.6 2 1 0 3 3 3 1 Inositol hexakisphosphate AXE1 PF05448.7 ERZ98251.1 - 3.8e-05 22.3 0.0 0.025 13.0 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Y_phosphatase PF00102.22 ERZ98251.1 - 9.8e-05 21.7 0.0 0.0002 20.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Hydrolase_4 PF12146.3 ERZ98251.1 - 0.0017 18.1 0.0 0.0044 16.8 0.0 1.8 1 0 0 1 1 1 1 Putative lysophospholipase Ser_hydrolase PF06821.8 ERZ98251.1 - 0.002 17.7 0.0 0.0042 16.6 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_2 PF02230.11 ERZ98251.1 - 0.017 14.5 0.1 0.76 9.1 0.0 2.9 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase BAAT_C PF08840.6 ERZ98251.1 - 0.031 13.9 0.0 0.089 12.4 0.0 1.7 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal PGAP1 PF07819.8 ERZ98251.1 - 0.041 13.4 0.1 0.21 11.1 0.0 2.1 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_4 PF08386.5 ERZ98251.1 - 0.069 13.0 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_8 PF06259.7 ERZ98251.1 - 0.24 10.8 0.0 0.96 8.9 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase zinc_ribbon_6 PF14599.1 ERZ98252.1 - 7e-26 89.8 0.9 7e-26 89.8 0.6 3.8 4 2 1 5 5 5 1 Zinc-ribbon zf-CHY PF05495.7 ERZ98252.1 - 1.6e-15 56.9 25.6 1.6e-15 56.9 17.7 4.6 3 1 0 3 3 3 2 CHY zinc finger zf-RING_2 PF13639.1 ERZ98252.1 - 3.6e-08 33.0 5.6 3.6e-08 33.0 3.9 5.6 4 1 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 ERZ98252.1 - 8.3e-07 28.9 6.0 8.3e-07 28.9 4.2 5.5 4 1 1 5 5 5 2 Zinc finger, C3HC4 type (RING finger) Sod_Fe_N PF00081.17 ERZ98252.1 - 0.024 14.9 0.1 0.079 13.2 0.0 1.9 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain DDE_1 PF03184.14 ERZ98253.1 - 2e-37 128.4 1.5 6.6e-33 113.6 0.0 2.4 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ98253.1 - 7.3e-15 54.5 0.8 3.1e-14 52.5 0.0 2.4 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ERZ98253.1 - 0.027 13.8 0.1 0.11 11.9 0.1 2.0 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_11 PF08279.7 ERZ98253.1 - 0.053 13.1 0.4 1.7 8.3 0.0 3.0 2 1 1 3 3 3 0 HTH domain WD40 PF00400.27 ERZ98255.1 - 3.1e-51 169.5 26.1 1e-09 37.9 0.2 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat Hira PF07569.6 ERZ98255.1 - 1.5e-43 148.5 0.0 2.6e-43 147.7 0.0 1.4 1 0 0 1 1 1 1 TUP1-like enhancer of split HIRA_B PF09453.5 ERZ98255.1 - 6.9e-07 28.6 0.1 1.6e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 HIRA B motif eIF2A PF08662.6 ERZ98255.1 - 1.9e-05 24.4 0.3 0.0028 17.3 0.0 3.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 ERZ98255.1 - 0.057 13.1 1.7 8.5 6.1 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat IKI3 PF04762.7 ERZ98255.1 - 0.12 10.1 0.2 1.2 6.8 0.0 2.3 2 1 1 3 3 3 0 IKI3 family BTB PF00651.26 ERZ98256.1 - 1.5e-14 53.9 0.2 1.8e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain PI-PLC-X PF00388.14 ERZ98256.1 - 0.0095 15.3 0.1 0.012 15.0 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF843 PF05814.6 ERZ98256.1 - 0.042 13.6 0.1 0.066 13.0 0.1 1.3 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) BTB_2 PF02214.17 ERZ98256.1 - 0.048 13.8 0.1 0.065 13.4 0.1 1.3 1 1 0 1 1 1 0 BTB/POZ domain DUF3769 PF12600.3 ERZ98256.1 - 0.067 11.9 0.0 0.067 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) F-box-like PF12937.2 ERZ98257.1 - 1.3e-07 31.1 0.2 4e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ98257.1 - 1.4e-06 27.7 0.1 5e-06 26.0 0.1 2.0 1 0 0 1 1 1 1 F-box domain Tox-MPTase5 PF15641.1 ERZ98257.1 - 0.053 13.4 0.1 0.16 11.9 0.1 1.8 1 1 0 1 1 1 0 Metallopeptidase toxin 5 DUF1463 PF07316.6 ERZ98259.1 - 0.079 12.5 0.9 0.15 11.6 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1463) DUF3825 PF12873.2 ERZ98260.1 - 0.0044 16.2 1.6 0.0055 15.8 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3825) IL6 PF00489.12 ERZ98260.1 - 0.024 14.2 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family PX PF00787.19 ERZ98260.1 - 0.045 13.5 0.3 0.25 11.1 0.0 2.3 2 1 0 2 2 2 0 PX domain SAC3_GANP PF03399.11 ERZ98260.1 - 0.059 12.9 1.4 0.08 12.4 0.6 1.7 1 1 1 2 2 2 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family DUF948 PF06103.6 ERZ98260.1 - 0.17 11.7 1.3 0.84 9.5 0.1 2.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-C4H2 PF10146.4 ERZ98260.1 - 0.27 11.2 1.1 1.3 9.0 0.1 2.0 2 0 0 2 2 2 0 Zinc finger-containing protein Erf4 PF10256.4 ERZ98260.1 - 0.37 10.6 3.4 1.5 8.7 2.4 2.1 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DASH_Dad1 PF08649.5 ERZ98260.1 - 0.63 9.7 4.9 4.7 6.9 0.1 3.1 3 0 0 3 3 3 0 DASH complex subunit Dad1 DUF972 PF06156.8 ERZ98262.1 - 0.022 15.0 7.1 0.052 13.8 3.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Troponin PF00992.15 ERZ98262.1 - 0.036 14.1 5.8 0.075 13.0 4.0 1.6 1 0 0 1 1 1 0 Troponin DivIC PF04977.10 ERZ98262.1 - 0.039 13.4 12.7 0.068 12.6 1.2 2.8 1 1 1 2 2 2 0 Septum formation initiator DUF904 PF06005.7 ERZ98262.1 - 0.041 14.1 0.7 0.041 14.1 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF904) TSC22 PF01166.13 ERZ98262.1 - 0.1 12.6 0.6 0.1 12.6 0.4 3.4 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF4530 PF15039.1 ERZ98262.1 - 0.11 12.4 2.2 0.2 11.5 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) HALZ PF02183.13 ERZ98262.1 - 0.16 11.7 3.1 0.097 12.4 0.6 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.3 ERZ98262.1 - 0.26 11.1 12.2 0.095 12.5 2.6 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Ead_Ea22 PF13935.1 ERZ98262.1 - 0.45 10.8 6.3 1.1 9.6 4.3 1.7 1 0 0 1 1 1 0 Ead/Ea22-like protein Microtub_assoc PF07989.6 ERZ98262.1 - 1.7 8.5 7.5 0.22 11.3 0.6 2.6 2 1 0 2 2 2 0 Microtubule associated zf-nanos PF05741.8 ERZ98265.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Nanos RNA binding domain DDE_1 PF03184.14 ERZ98267.1 - 3.3e-56 189.8 2.2 5.5e-56 189.1 1.6 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ98267.1 - 2.9e-15 55.8 0.0 1.4e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ERZ98267.1 - 0.00023 20.9 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.8 ERZ98267.1 - 0.0017 17.7 0.2 0.0037 16.6 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Ribosomal_S3Ae PF01015.13 ERZ98268.1 - 2.3e-85 284.8 4.6 2.7e-85 284.6 3.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.11 ERZ98268.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region CUE PF02845.11 ERZ98269.1 - 2.3e-06 26.9 0.1 4.1e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 CUE domain DUF1296 PF06972.6 ERZ98269.1 - 0.00013 21.8 0.2 0.0002 21.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) Mod_r PF07200.8 ERZ98269.1 - 0.0071 16.2 1.4 0.0071 16.2 1.0 1.5 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein DUF664 PF04978.7 ERZ98269.1 - 0.061 13.5 0.1 0.081 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF664) Dynactin_p62 PF05502.8 ERZ98269.1 - 0.33 9.6 1.7 0.36 9.5 1.1 1.0 1 0 0 1 1 1 0 Dynactin p62 family FlaG PF03646.10 ERZ98269.1 - 0.69 10.0 3.8 0.28 11.3 0.1 1.8 2 0 0 2 2 2 0 FlaG protein TLD PF07534.11 ERZ98271.1 - 8.4e-14 51.7 3.3 1.1e-13 51.3 2.3 1.2 1 0 0 1 1 1 1 TLD SH2 PF00017.19 ERZ98271.1 - 0.097 12.4 0.3 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 SH2 domain SIR2 PF02146.12 ERZ98272.1 - 2e-42 144.9 0.0 2.6e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family CpXC PF14353.1 ERZ98272.1 - 0.088 12.7 0.1 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 CpXC protein IF-2B PF01008.12 ERZ98272.1 - 0.13 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family MIP-T3 PF10243.4 ERZ98273.1 - 0.18 10.2 30.7 0.23 9.8 21.3 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GerA PF03323.8 ERZ98273.1 - 0.18 9.8 0.0 0.18 9.8 0.0 1.9 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein DUF4554 PF15091.1 ERZ98273.1 - 8.2 5.0 15.6 11 4.5 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Endonuclease_NS PF01223.18 ERZ98274.1 - 6.7e-57 192.4 0.0 8.6e-57 192.1 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DSPc PF00782.15 ERZ98275.1 - 2.3e-15 56.3 0.8 6.6e-15 54.8 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.7 ERZ98275.1 - 1.2e-09 37.8 0.3 2.5e-09 36.8 0.2 1.6 1 1 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.22 ERZ98275.1 - 0.00022 20.6 0.1 0.00033 20.0 0.1 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ERZ98275.1 - 0.00085 19.3 0.0 0.0021 18.1 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate DUF605 PF04652.11 ERZ98276.1 - 0.56 9.5 23.7 0.67 9.2 16.5 1.3 1 0 0 1 1 1 0 Vta1 like Thioredoxin PF00085.15 ERZ98277.1 - 2.2e-05 24.0 0.1 2.9e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.11 ERZ98277.1 - 0.025 14.0 0.3 0.031 13.7 0.2 1.2 1 0 0 1 1 1 0 Mitosis protein DIM1 Phosducin PF02114.11 ERZ98277.1 - 0.028 13.1 0.1 0.032 12.9 0.1 1.1 1 0 0 1 1 1 0 Phosducin zf-CCHC_4 PF14392.1 ERZ98278.1 - 0.074 12.7 1.5 0.1 12.2 1.0 1.2 1 0 0 1 1 1 0 Zinc knuckle PHD PF00628.24 ERZ98280.1 - 9.2e-15 54.0 7.9 1.1e-14 53.8 5.5 1.1 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.17 ERZ98280.1 - 0.011 15.4 1.3 0.011 15.4 0.9 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.1 ERZ98280.1 - 0.021 14.7 4.1 0.028 14.4 2.8 1.3 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-H2C2_2 PF13465.1 ERZ98280.1 - 0.035 14.4 1.8 4.4 7.7 0.1 2.4 2 1 0 2 2 2 0 Zinc-finger double domain zf-HC5HC2H PF13771.1 ERZ98280.1 - 0.045 13.8 4.7 0.058 13.5 3.3 1.3 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.1 ERZ98280.1 - 0.11 12.2 5.2 0.16 11.8 3.6 1.2 1 0 0 1 1 1 0 Ring finger domain Terminase_GpA PF05876.7 ERZ98280.1 - 0.16 10.3 4.2 0.16 10.2 2.9 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) PHD_2 PF13831.1 ERZ98280.1 - 0.93 8.8 7.2 0.21 10.9 2.7 1.7 2 0 0 2 2 2 0 PHD-finger zf-RING-like PF08746.6 ERZ98280.1 - 1.3 9.0 5.6 3.1 7.8 3.9 1.6 1 1 0 1 1 1 0 RING-like domain Isy1 PF06246.7 ERZ98281.1 - 5.4e-97 324.1 12.1 6.1e-97 324.0 8.4 1.0 1 0 0 1 1 1 1 Isy1-like splicing family DUF310 PF03750.8 ERZ98281.1 - 0.045 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF310) NdhM PF10664.4 ERZ98281.1 - 0.1 12.4 0.9 0.45 10.4 0.1 2.1 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M DivIC PF04977.10 ERZ98281.1 - 0.18 11.2 3.1 0.39 10.2 0.0 2.7 2 1 1 3 3 3 0 Septum formation initiator EF-hand_7 PF13499.1 ERZ98282.1 - 5.9e-19 67.9 0.9 2.6e-13 49.8 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ERZ98282.1 - 6.1e-15 53.3 8.6 1.7e-05 23.7 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 ERZ98282.1 - 1.5e-14 52.5 3.1 2.5e-05 23.7 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 ERZ98282.1 - 1.8e-12 46.6 1.8 3.9e-07 29.5 0.2 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 ERZ98282.1 - 3e-09 36.6 0.0 0.00011 21.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 ERZ98282.1 - 0.00044 19.4 5.1 0.018 14.4 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_4 PF12763.2 ERZ98282.1 - 0.0045 16.6 0.1 0.01 15.5 0.0 1.5 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Exo70 PF03081.10 ERZ98283.1 - 3.6e-87 292.5 2.8 3.6e-87 292.5 1.9 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Mannosyl_trans PF05007.8 ERZ98284.1 - 1.8e-65 221.1 17.3 3.1e-65 220.3 12.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 ERZ98284.1 - 2.3e-18 66.2 24.4 2.8e-18 65.9 16.9 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 ERZ98284.1 - 5.2e-07 29.4 1.1 5.2e-07 29.4 0.7 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2029) DUF262 PF03235.9 ERZ98287.1 - 4.8e-16 59.4 0.3 8.8e-16 58.5 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function DUF262 Herpes_LMP1 PF05297.6 ERZ98288.1 - 1.7 7.4 5.5 1.7 7.4 3.8 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) LRR_6 PF13516.1 ERZ98289.1 - 1.3e-13 49.4 4.8 0.0018 18.1 0.0 4.4 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.2 ERZ98289.1 - 1.9e-12 46.4 0.3 8.3e-05 22.1 0.0 2.4 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ98289.1 - 1.3e-10 39.7 3.1 0.056 13.4 0.1 4.4 4 0 0 4 4 4 4 Leucine Rich Repeat LRR_8 PF13855.1 ERZ98289.1 - 1.4e-10 40.7 2.4 8.1e-08 31.9 0.1 2.3 1 1 2 3 3 3 2 Leucine rich repeat LRR_7 PF13504.1 ERZ98289.1 - 8.8e-09 34.1 0.7 0.61 10.5 0.0 4.5 4 0 0 4 4 4 2 Leucine rich repeat MYCBPAP PF14646.1 ERZ98289.1 - 0.096 11.3 0.1 0.17 10.5 0.1 1.5 1 1 0 1 1 1 0 MYCBP-associated protein family LRR_2 PF07723.8 ERZ98289.1 - 0.34 11.4 3.9 2.4 8.7 0.6 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat DUF4357 PF14267.1 ERZ98291.1 - 0.12 11.9 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) RNA_Me_trans PF04252.8 ERZ98295.1 - 0.021 14.2 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase FAM72 PF14976.1 ERZ98297.1 - 1.8e-52 177.1 6.4 2e-52 177.0 4.4 1.0 1 0 0 1 1 1 1 FAM72 protein Yippee-Mis18 PF03226.9 ERZ98297.1 - 0.072 13.1 13.8 0.27 11.3 7.5 2.2 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Gp_dh_C PF02800.15 ERZ98300.1 - 0.54 9.7 4.8 0.19 11.1 0.9 2.0 2 1 1 3 3 3 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain TLD PF07534.11 ERZ98301.1 - 0.00052 20.0 0.6 0.00071 19.5 0.4 1.2 1 0 0 1 1 1 1 TLD DDE_Tnp_1_6 PF13751.1 ERZ98303.1 - 6.7 6.7 7.7 0.37 10.8 1.2 1.9 2 0 0 2 2 2 0 Transposase DDE domain NTNH_C PF08470.5 ERZ98304.1 - 0.05 13.2 1.8 0.093 12.3 0.3 1.8 2 0 0 2 2 2 0 Nontoxic nonhaemagglutinin C-terminal BRCA-2_OB1 PF09103.5 ERZ98305.1 - 3.9e-29 100.7 0.0 9e-29 99.5 0.0 1.6 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.5 ERZ98305.1 - 2.1e-21 76.4 0.7 1.7e-17 63.6 0.4 2.7 2 0 0 2 2 2 2 BRCA2, helical BRCA2 PF00634.13 ERZ98305.1 - 9.3e-08 31.2 0.3 0.27 10.5 0.2 3.6 3 0 0 3 3 3 3 BRCA2 repeat SPRY PF00622.23 ERZ98306.1 - 1.3e-21 76.9 0.3 2.4e-21 76.0 0.2 1.5 1 0 0 1 1 1 1 SPRY domain DUF4029 PF13221.1 ERZ98306.1 - 0.7 10.3 4.0 0.56 10.6 1.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4029) Ribosomal_L19 PF01245.15 ERZ98307.1 - 0.015 15.1 0.4 0.035 13.8 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein L19 DUF972 PF06156.8 ERZ98307.1 - 6.7 7.1 8.6 0.42 10.9 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Calsequestrin PF01216.12 ERZ98308.1 - 0.014 14.2 0.2 0.017 13.9 0.1 1.2 1 0 0 1 1 1 0 Calsequestrin GTP-bdg_N PF13167.1 ERZ98308.1 - 0.11 12.6 3.4 0.15 12.2 0.6 2.3 2 1 0 2 2 2 0 GTP-binding GTPase N-terminal Piwi PF02171.12 ERZ98309.1 - 8.1e-88 294.2 0.0 1.2e-87 293.6 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ98309.1 - 2.1e-17 62.6 0.0 4.6e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ98309.1 - 5.1e-06 25.7 0.0 1.3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) UTRA PF07702.8 ERZ98309.1 - 0.16 11.5 0.1 0.43 10.1 0.0 1.7 2 0 0 2 2 2 0 UTRA domain Sel1 PF08238.7 ERZ98311.1 - 1.1e-31 108.5 11.2 1.2e-09 38.4 0.2 4.5 5 0 0 5 5 5 4 Sel1 repeat TPR_11 PF13414.1 ERZ98311.1 - 0.0014 18.2 8.8 0.0062 16.1 0.2 3.1 2 1 2 4 4 4 3 TPR repeat TPR_12 PF13424.1 ERZ98311.1 - 0.031 14.2 4.8 0.64 9.9 0.2 3.7 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ98311.1 - 0.11 13.0 3.8 16 6.2 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ERZ98311.1 - 1.7 8.5 6.3 19 5.2 0.4 3.8 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain Methyltransf_11 PF08241.7 ERZ98312.1 - 4.6e-12 46.2 0.0 9.5e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ98312.1 - 9.7e-11 41.6 0.0 2.5e-10 40.3 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ98312.1 - 2.3e-10 40.2 0.0 6.1e-10 38.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ98312.1 - 2.5e-08 34.1 0.0 5.5e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ98312.1 - 4.9e-07 30.1 0.2 3e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ98312.1 - 7.9e-07 29.6 0.0 2.4e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ERZ98312.1 - 1.2e-05 24.4 0.0 3.3e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 ERZ98312.1 - 0.00033 19.8 0.0 0.00074 18.7 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ERZ98312.1 - 0.00039 19.8 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 ERZ98312.1 - 0.0013 18.7 0.0 0.0033 17.4 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ERZ98312.1 - 0.019 15.0 0.0 0.04 13.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain TehB PF03848.9 ERZ98312.1 - 0.065 12.3 0.0 0.15 11.1 0.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB Dimer_Tnp_hAT PF05699.9 ERZ98313.1 - 7.2e-11 41.5 0.0 1.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region NinB PF05772.7 ERZ98313.1 - 0.047 13.3 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 NinB protein PAS_9 PF13426.1 ERZ98317.1 - 5.3e-33 113.4 0.0 5.4e-19 68.4 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.6 ERZ98317.1 - 3.5e-24 84.7 0.0 3.1e-13 49.6 0.0 3.6 3 0 0 3 3 3 3 PAS fold PAS PF00989.19 ERZ98317.1 - 4.1e-18 65.2 0.0 5.2e-05 22.9 0.0 4.1 3 1 0 3 3 3 3 PAS fold PAS_11 PF14598.1 ERZ98317.1 - 1.6e-13 50.5 0.1 6.1e-06 26.1 0.1 2.8 2 0 0 2 2 2 2 PAS domain GATA PF00320.22 ERZ98317.1 - 2.2e-12 46.0 6.0 2.6e-12 45.8 3.1 2.0 2 0 0 2 2 2 1 GATA zinc finger PAS_4 PF08448.5 ERZ98317.1 - 4.2e-08 33.1 0.0 0.12 12.4 0.0 3.4 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.1 ERZ98317.1 - 0.00013 21.7 0.0 1.9 8.4 0.0 3.6 3 0 0 3 3 3 2 PAS domain DUF3357 PF11837.3 ERZ98318.1 - 0.0057 16.4 0.0 0.0069 16.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3357) Kelch_3 PF13415.1 ERZ98319.1 - 1.7e-16 59.8 9.8 0.00038 20.5 0.0 6.5 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.1 ERZ98319.1 - 8.2e-15 54.3 17.0 0.0015 18.2 0.1 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ERZ98319.1 - 1.4e-14 53.6 18.8 0.00035 20.4 0.9 6.6 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ERZ98319.1 - 7.5e-12 44.8 16.6 0.055 13.6 0.0 6.8 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.10 ERZ98319.1 - 2.3e-09 36.6 5.6 1.1 9.0 0.1 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ERZ98319.1 - 6.9e-08 31.9 18.6 0.015 14.8 0.0 5.7 5 1 0 5 5 5 3 Kelch motif TMEM154 PF15102.1 ERZ98319.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family p450 PF00067.17 ERZ98320.1 - 3.3e-80 269.8 0.5 4.3e-80 269.4 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ubiq_cyt_C_chap PF03981.7 ERZ98320.1 - 0.0023 17.7 1.5 0.0044 16.8 0.2 2.0 3 0 0 3 3 3 1 Ubiquinol-cytochrome C chaperone LZ_Tnp_IS66 PF13007.2 ERZ98320.1 - 0.0033 18.0 0.1 0.035 14.7 0.0 2.3 1 1 1 2 2 2 1 Transposase C of IS166 homeodomain UCH PF00443.24 ERZ98320.1 - 0.029 13.4 0.4 0.035 13.2 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase F-box-like PF12937.2 ERZ98322.1 - 4.5e-05 23.0 0.1 0.00015 21.4 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ98322.1 - 6.9 6.4 8.7 0.8 9.4 0.7 3.3 3 0 0 3 3 3 0 F-box domain Sel1 PF08238.7 ERZ98324.1 - 4.7e-18 65.2 7.1 1.2e-11 44.8 0.3 2.8 3 0 0 3 3 3 2 Sel1 repeat MIT PF04212.13 ERZ98324.1 - 0.0015 18.3 3.5 0.24 11.3 0.1 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Ribonuc_red_sm PF00268.16 ERZ98324.1 - 0.0018 17.3 2.0 0.0076 15.2 0.4 1.9 1 1 1 2 2 2 1 Ribonucleotide reductase, small chain TPR_11 PF13414.1 ERZ98324.1 - 0.0083 15.7 9.8 0.0092 15.6 6.2 1.5 1 1 0 1 1 1 1 TPR repeat FTCD_N PF07837.7 ERZ98324.1 - 0.037 13.5 0.8 0.05 13.1 0.1 1.6 2 0 0 2 2 2 0 Formiminotransferase domain, N-terminal subdomain DUF406 PF04175.7 ERZ98324.1 - 0.059 13.8 0.5 0.11 13.0 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF406) Ank_2 PF12796.2 ERZ98324.1 - 0.09 13.1 0.3 0.15 12.3 0.2 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) TPR_12 PF13424.1 ERZ98324.1 - 0.09 12.7 5.0 0.18 11.7 3.1 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat zf-RING_3 PF14369.1 ERZ98324.1 - 0.24 11.4 3.1 0.32 11.0 0.3 2.1 1 1 1 2 2 2 0 zinc-finger TPR_2 PF07719.12 ERZ98324.1 - 1 9.4 9.0 11 6.2 0.2 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.27 ERZ98326.1 - 1.2e-57 189.7 17.8 3.9e-09 36.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.2 ERZ98326.1 - 2.2e-11 43.2 0.7 4.4e-11 42.3 0.5 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 ERZ98326.1 - 3.6e-09 35.3 7.3 0.0018 16.5 0.3 5.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 F-box PF00646.28 ERZ98326.1 - 0.00041 19.9 1.7 0.00095 18.7 1.2 1.7 1 0 0 1 1 1 1 F-box domain Nucleoporin_N PF08801.6 ERZ98326.1 - 0.0024 16.7 0.1 0.07 11.8 0.0 2.4 1 1 0 2 2 2 1 Nup133 N terminal like BBS2_Mid PF14783.1 ERZ98326.1 - 0.041 13.6 0.2 3.3 7.5 0.0 3.5 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region DUF3295 PF11702.3 ERZ98327.1 - 8.2 5.2 6.7 11 4.8 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) ER PF01133.12 ERZ98329.1 - 0.14 11.8 0.3 0.24 11.1 0.1 1.6 2 0 0 2 2 2 0 Enhancer of rudimentary Pkinase_Tyr PF07714.12 ERZ98330.1 - 4.5e-21 75.0 0.0 6.2e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98330.1 - 5.1e-14 52.0 2.0 1.3e-13 50.7 1.4 1.7 1 1 0 1 1 1 1 Protein kinase domain XPA_N PF01286.13 ERZ98330.1 - 0.11 12.2 0.6 0.27 10.9 0.4 1.7 1 0 0 1 1 1 0 XPA protein N-terminal Syntaxin PF00804.20 ERZ98331.1 - 0.03 14.4 0.5 0.03 14.4 0.3 1.9 2 0 0 2 2 2 0 Syntaxin DUF247 PF03140.10 ERZ98335.1 - 0.00068 18.7 0.2 0.00091 18.3 0.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function MAS20 PF02064.10 ERZ98335.1 - 0.071 13.0 0.8 0.092 12.6 0.6 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor BTB PF00651.26 ERZ98336.1 - 5.7e-20 71.3 0.2 1.7e-19 69.8 0.2 1.9 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ98336.1 - 2.5e-08 34.0 4.5 2.5e-08 34.0 3.1 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ98336.1 - 1.4e-07 31.3 0.3 1.5e-06 27.9 0.1 2.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch EURL PF06937.6 ERZ98337.1 - 0.0083 15.5 1.2 0.0085 15.5 0.8 1.1 1 0 0 1 1 1 1 EURL protein Sec16 PF12932.2 ERZ98337.1 - 0.01 15.7 0.9 0.01 15.7 0.6 1.4 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region EB1_binding PF05937.6 ERZ98337.1 - 0.016 15.6 7.3 0.018 15.4 5.0 1.1 1 0 0 1 1 1 0 EB-1 Binding Domain NPBW PF15180.1 ERZ98337.1 - 0.072 12.7 0.1 0.099 12.2 0.0 1.2 1 0 0 1 1 1 0 Neuropeptides B and W Tn7_Tnp_TnsA_N PF08722.6 ERZ98338.1 - 0.015 15.2 1.0 0.035 14.0 0.1 1.9 2 0 0 2 2 2 0 TnsA endonuclease N terminal INCENP_ARK-bind PF03941.10 ERZ98339.1 - 2.1e-10 40.3 0.6 2.1e-10 40.3 0.4 3.0 3 0 0 3 3 3 1 Inner centromere protein, ARK binding region SSXRD PF09514.5 ERZ98339.1 - 0.62 9.4 4.2 13 5.1 0.1 3.5 3 0 0 3 3 3 0 SSXRD motif Totivirus_coat PF05518.6 ERZ98339.1 - 1.2 6.9 4.1 1.4 6.6 2.9 1.1 1 0 0 1 1 1 0 Totivirus coat protein Astro_capsid PF03115.9 ERZ98339.1 - 1.4 7.0 7.5 2 6.5 5.1 1.3 1 1 0 1 1 1 0 Astrovirus capsid protein precursor ABC2_membrane_5 PF13346.1 ERZ98340.1 - 0.018 14.3 0.2 0.027 13.7 0.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein AAA_14 PF13173.1 ERZ98341.1 - 0.026 14.4 0.1 0.29 11.0 0.0 2.2 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.22 ERZ98341.1 - 0.039 14.2 0.1 0.082 13.2 0.0 1.6 2 0 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 ERZ98341.1 - 0.054 13.1 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase Pkinase_Tyr PF07714.12 ERZ98348.1 - 6.7e-34 117.1 0.0 1.1e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98348.1 - 5.5e-33 114.2 0.0 1.3e-32 113.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF1542 PF07564.6 ERZ98348.1 - 0.016 15.2 0.3 0.029 14.3 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Kdo PF06293.9 ERZ98348.1 - 0.062 12.3 0.6 0.39 9.7 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pentapeptide_3 PF13576.1 ERZ98351.1 - 0.41 10.5 2.1 3 7.8 0.2 2.2 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) IF3_N PF05198.11 ERZ98353.1 - 0.039 13.8 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain Gemini_AC4_5 PF04807.7 ERZ98355.1 - 0.036 13.5 0.0 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 Geminivirus AC4/5 conserved region ABC2_membrane_3 PF12698.2 ERZ98355.1 - 1.2 8.1 6.2 0.69 8.8 3.0 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein MerB PF03243.10 ERZ98356.1 - 0.0012 18.6 1.1 0.013 15.3 0.1 2.0 1 1 1 2 2 2 1 Alkylmercury lyase FAR1 PF03101.10 ERZ98356.1 - 0.019 15.4 0.3 0.038 14.5 0.2 1.5 1 0 0 1 1 1 0 FAR1 DNA-binding domain DUF3246 PF11596.3 ERZ98357.1 - 0.099 11.9 1.2 0.15 11.3 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) UvrD_C_2 PF13538.1 ERZ98358.1 - 0.014 15.5 0.0 0.076 13.1 0.0 2.2 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.1 ERZ98358.1 - 0.09 12.3 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AP-5_subunit_s1 PF15001.1 ERZ98360.1 - 0.048 13.6 0.1 0.071 13.0 0.0 1.3 1 1 0 1 1 1 0 AP-5 complex subunit sigma-1 Tubulin-binding PF00418.14 ERZ98360.1 - 0.091 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Tau and MAP protein, tubulin-binding repeat SAC3_GANP PF03399.11 ERZ98361.1 - 0.1 12.1 2.0 1.3 8.4 0.0 2.0 1 1 0 2 2 2 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family ORF6C PF10552.4 ERZ98361.1 - 0.23 11.2 2.6 0.81 9.4 0.5 2.3 1 1 1 2 2 2 0 ORF6C domain Hormone_1 PF00103.15 ERZ98362.1 - 0.081 12.2 0.4 0.086 12.1 0.3 1.0 1 0 0 1 1 1 0 Somatotropin hormone family zf-RING_2 PF13639.1 ERZ98364.1 - 4.9e-17 61.4 4.8 7.6e-17 60.8 3.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ERZ98364.1 - 1e-10 41.0 3.4 1.7e-10 40.3 2.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ERZ98364.1 - 5.4e-10 39.1 3.6 8.7e-10 38.4 2.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ERZ98364.1 - 1.2e-08 34.8 3.6 2.4e-08 33.9 2.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ERZ98364.1 - 1.7e-07 30.8 2.9 2.6e-07 30.2 2.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ERZ98364.1 - 6.9e-05 22.4 5.0 0.0001 21.8 3.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ERZ98364.1 - 0.00054 19.7 3.9 0.00065 19.5 1.6 1.9 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 ERZ98364.1 - 0.00065 19.4 2.6 0.0011 18.7 1.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 ERZ98364.1 - 0.0026 17.7 2.1 0.006 16.5 1.5 1.6 1 1 0 1 1 1 1 RING-variant domain zf-RING_4 PF14570.1 ERZ98364.1 - 0.003 17.0 3.7 0.0046 16.5 2.6 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain PHD PF00628.24 ERZ98364.1 - 0.0041 16.7 3.4 0.0065 16.1 2.4 1.3 1 0 0 1 1 1 1 PHD-finger zf-RING_UBOX PF13445.1 ERZ98364.1 - 0.034 13.8 5.1 0.077 12.7 3.6 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING-like PF08746.6 ERZ98364.1 - 0.083 12.8 3.1 0.13 12.2 2.1 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.3 ERZ98364.1 - 0.3 11.0 5.0 1 9.3 3.4 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.1 ERZ98364.1 - 0.75 9.5 3.2 0.39 10.4 0.2 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DUF4495 PF14906.1 ERZ98366.1 - 0.23 10.3 2.1 0.26 10.1 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4495) zf-C4pol PF14260.1 ERZ98366.1 - 0.62 10.1 6.5 1.5 8.8 4.5 1.8 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta p450 PF00067.17 ERZ98368.1 - 2.9e-48 164.5 0.0 3.2e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ERZ98368.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) Sel1 PF08238.7 ERZ98370.1 - 1e-30 105.4 2.4 1.6e-10 41.2 0.1 3.0 3 0 0 3 3 3 3 Sel1 repeat TPR_17 PF13431.1 ERZ98370.1 - 0.014 15.5 0.6 18 5.8 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Phage_terminase PF10668.4 ERZ98370.1 - 0.11 12.3 0.3 11 5.9 0.0 2.8 2 1 1 3 3 3 0 Phage terminase small subunit TLD PF07534.11 ERZ98371.1 - 4.2e-13 49.4 0.5 6.5e-13 48.8 0.3 1.3 1 0 0 1 1 1 1 TLD DUF3688 PF12461.3 ERZ98371.1 - 0.084 13.2 1.8 8.1 6.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3688) Hint PF01079.15 ERZ98372.1 - 1.5e-33 115.8 0.0 2.3e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Hint module AIG1 PF04548.11 ERZ98372.1 - 1.2e-15 57.2 0.8 2.3e-15 56.3 0.2 1.7 2 0 0 2 2 2 1 AIG1 family Vint PF14623.1 ERZ98372.1 - 0.00027 20.4 0.0 0.00049 19.6 0.0 1.4 1 0 0 1 1 1 1 Hint-domain MMR_HSR1 PF01926.18 ERZ98372.1 - 0.0006 19.7 0.1 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ98372.1 - 0.0025 17.6 0.0 0.0085 15.9 0.1 1.8 2 0 0 2 2 2 1 Dynamin family SRPRB PF09439.5 ERZ98372.1 - 0.018 14.2 0.1 0.036 13.2 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Exotox-A_target PF09102.5 ERZ98372.1 - 0.023 14.1 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Exotoxin A, targeting Cytomega_TRL10 PF06084.6 ERZ98374.1 - 0.039 13.7 0.2 0.039 13.7 0.1 2.1 1 1 0 2 2 2 0 Cytomegalovirus TRL10 protein UPF0154 PF03672.8 ERZ98374.1 - 0.12 12.0 0.1 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) Herpes_gE PF02480.11 ERZ98375.1 - 0.11 10.7 0.0 0.12 10.6 0.0 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF2198 PF09964.4 ERZ98375.1 - 0.13 12.0 0.1 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) zf-BED PF02892.10 ERZ98378.1 - 0.00017 21.2 0.2 0.00034 20.3 0.1 1.5 1 0 0 1 1 1 1 BED zinc finger PNK3P PF08645.6 ERZ98378.1 - 0.042 13.2 0.0 0.08 12.3 0.0 1.4 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase FAM60A PF15396.1 ERZ98378.1 - 0.046 13.4 1.1 0.1 12.3 0.1 1.8 1 1 1 2 2 2 0 Protein Family FAM60A zf-BED PF02892.10 ERZ98379.1 - 0.0022 17.6 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 BED zinc finger Dynein_IC2 PF11540.3 ERZ98382.1 - 0.05 12.9 0.8 0.072 12.4 0.5 1.2 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 Bul1_C PF04426.7 ERZ98382.1 - 0.49 9.5 1.7 0.58 9.2 1.2 1.1 1 0 0 1 1 1 0 Bul1 C terminus TLD PF07534.11 ERZ98383.1 - 5.7e-15 55.5 3.6 5.7e-15 55.5 2.5 2.2 2 1 0 2 2 2 1 TLD DUF3942 PF13078.1 ERZ98383.1 - 0.019 15.0 3.0 0.069 13.2 2.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) Pkinase_Tyr PF07714.12 ERZ98384.1 - 1.5e-25 89.7 0.0 7.5e-12 44.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ98384.1 - 8.9e-25 87.2 0.0 1.5e-14 53.7 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain LRAT PF04970.8 ERZ98385.1 - 0.11 12.4 0.3 0.11 12.4 0.2 1.1 1 0 0 1 1 1 0 Lecithin retinol acyltransferase LIM PF00412.17 ERZ98386.1 - 1.7e-24 85.6 19.1 3.2e-13 49.5 4.5 2.1 2 0 0 2 2 2 2 LIM domain zf-FPG_IleRS PF06827.9 ERZ98386.1 - 0.047 13.3 15.5 0.094 12.3 0.1 4.4 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS Zn_Tnp_IS1595 PF12760.2 ERZ98386.1 - 0.061 13.1 0.7 0.061 13.1 0.5 3.9 2 2 2 4 4 4 0 Transposase zinc-ribbon domain zf-LYAR PF08790.6 ERZ98386.1 - 0.09 12.5 0.1 0.09 12.5 0.1 2.5 2 1 1 3 3 3 0 LYAR-type C2HC zinc finger Cytochrom_c3_2 PF14537.1 ERZ98386.1 - 1.7 9.0 11.7 0.91 9.9 1.9 2.3 2 0 0 2 2 2 0 Cytochrome c3 zf-CCHC_5 PF14787.1 ERZ98386.1 - 6.7 6.2 12.4 4.6 6.8 0.0 3.9 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger Cytochrome_C7 PF14522.1 ERZ98386.1 - 7.2 6.3 11.4 0.43 10.2 1.3 2.7 2 1 0 2 2 2 0 Cytochrome c7 Ribosomal_S27 PF01599.14 ERZ98386.1 - 7.9 6.3 16.1 4.4 7.1 0.0 4.0 4 1 0 4 4 4 0 Ribosomal protein S27a Ferrochelatase PF00762.14 ERZ98387.1 - 5.2e-106 354.1 0.0 6e-106 353.9 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase RhoGAP PF00620.22 ERZ98388.1 - 6.2e-17 61.6 0.3 1.2e-15 57.4 0.0 2.7 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.18 ERZ98388.1 - 9.4e-17 60.9 0.2 6.7e-16 58.2 0.0 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.16 ERZ98388.1 - 1.6e-10 40.5 0.0 4.3e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Amidohydro_2 PF04909.9 ERZ98391.1 - 2.3e-08 33.9 0.0 3.5e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase DUF3418 PF11898.3 ERZ98392.1 - 0.025 13.0 0.0 0.029 12.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Neuropep_like PF15161.1 ERZ98392.1 - 0.095 12.1 0.1 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 Neuropeptide-like Peptidase_M17_N PF02789.12 ERZ98393.1 - 2.3e-16 59.6 0.7 2.8e-16 59.4 0.5 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.16 ERZ98394.1 - 1.5e-87 293.4 0.1 4.4e-82 275.4 0.0 2.0 1 1 1 2 2 2 2 Cytosol aminopeptidase family, catalytic domain Herpes_glycop_H PF02489.11 ERZ98395.1 - 0.023 12.7 0.8 0.027 12.4 0.5 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein H DUF1219 PF06755.7 ERZ98395.1 - 0.17 11.3 0.6 0.2 11.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1219) ubiquitin PF00240.18 ERZ98396.1 - 3.7e-21 74.3 0.0 6.6e-21 73.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ98396.1 - 5e-09 35.7 0.1 1.2e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ERZ98396.1 - 0.00014 21.3 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ubiquitin_2 PF14560.1 ERZ98396.1 - 0.0061 16.7 0.0 0.019 15.1 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2870 PF11069.3 ERZ98396.1 - 0.088 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) GSHPx PF00255.14 ERZ98397.1 - 5.4e-43 144.7 0.2 6.5e-43 144.5 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 ERZ98397.1 - 0.00011 21.9 0.1 0.00022 20.8 0.1 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ERZ98397.1 - 0.0011 18.4 0.2 0.0025 17.3 0.2 1.6 1 1 0 1 1 1 1 Redoxin PPTA PF01239.17 ERZ98397.1 - 0.15 11.5 0.2 0.37 10.2 0.1 1.7 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat CAF1 PF04857.15 ERZ98398.1 - 2.4e-53 181.1 7.4 3.6e-53 180.5 5.1 1.3 1 0 0 1 1 1 1 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.15 ERZ98398.1 - 1.2e-05 24.8 0.0 0.0049 16.3 0.0 2.7 2 1 0 2 2 2 2 3'-5' exonuclease Es2 PF09751.4 ERZ98399.1 - 4.9e-75 253.4 9.0 2.6e-74 251.1 6.3 1.9 1 1 0 1 1 1 1 Nuclear protein Es2 Shadoo PF14999.1 ERZ98399.1 - 0.01 15.6 1.1 0.021 14.7 0.8 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective TLD PF07534.11 ERZ98400.1 - 2.1e-14 53.6 1.7 2.1e-14 53.6 1.2 2.1 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ98400.1 - 3e-08 33.4 2.1 1e-06 28.5 0.3 3.3 2 1 2 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ98400.1 - 3e-08 33.6 0.2 6.8e-08 32.4 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Fic PF02661.13 ERZ98401.1 - 1.4e-15 57.7 0.0 2.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Fic/DOC family NPP PF08384.5 ERZ98401.1 - 0.28 10.8 2.4 0.19 11.3 0.2 1.8 2 0 0 2 2 2 0 Pro-opiomelanocortin, N-terminal region RINT1_TIP1 PF04437.8 ERZ98402.1 - 4.8e-44 150.7 0.1 4.8e-44 150.7 0.1 2.2 2 1 0 2 2 2 1 RINT-1 / TIP-1 family Retrotrans_gag PF03732.12 ERZ98402.1 - 3.3 7.8 6.0 2.1 8.4 0.0 3.4 2 1 1 3 3 3 0 Retrotransposon gag protein Pkinase PF00069.20 ERZ98403.1 - 3.1e-67 226.4 0.0 4e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98403.1 - 2.2e-36 125.2 0.0 2.4e-32 112.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98403.1 - 2.7e-10 39.6 0.0 1.2e-09 37.5 0.0 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ98403.1 - 0.0025 17.6 0.0 0.0085 15.8 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family YukC PF10140.4 ERZ98403.1 - 0.093 11.2 0.2 0.14 10.6 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC AAA_22 PF13401.1 ERZ98407.1 - 0.003 17.7 0.0 0.003 17.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 ERZ98407.1 - 0.0047 16.4 0.0 0.0047 16.4 0.0 1.1 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.1 ERZ98407.1 - 0.014 16.2 0.1 0.017 15.9 0.1 1.3 1 1 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 ERZ98407.1 - 0.031 13.5 0.0 0.033 13.5 0.0 1.3 1 1 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.1 ERZ98407.1 - 0.032 14.2 0.0 0.033 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 ERZ98407.1 - 0.046 14.0 0.0 0.051 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ERZ98407.1 - 0.055 13.1 0.0 0.055 13.1 0.0 1.1 1 0 0 1 1 1 0 Archaeal ATPase AAA PF00004.24 ERZ98407.1 - 0.075 13.2 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 ERZ98407.1 - 0.079 12.4 0.2 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF3265 PF11665.3 ERZ98407.1 - 0.26 11.1 1.3 0.5 10.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3265) Epsilon_antitox PF08998.6 ERZ98409.1 - 0.11 12.4 1.5 0.13 12.2 1.1 1.3 1 1 0 1 1 1 0 Bacterial epsilon antitoxin Ofd1_CTDD PF10637.4 ERZ98409.1 - 0.16 11.0 3.4 0.18 10.9 2.3 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Pkinase PF00069.20 ERZ98410.1 - 9.6e-25 87.2 0.0 1.3e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98410.1 - 2.8e-22 79.0 0.0 3.3e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98410.1 - 0.0003 19.8 0.0 0.00033 19.7 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ98410.1 - 0.00036 20.3 0.3 0.00077 19.2 0.3 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ98410.1 - 0.00052 19.1 0.0 0.00054 19.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ98410.1 - 0.0018 17.6 0.1 0.002 17.5 0.1 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ERZ98410.1 - 0.031 13.4 0.1 0.031 13.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) LRR_8 PF13855.1 ERZ98411.1 - 2.4e-13 49.5 3.7 2.1e-07 30.6 0.3 3.9 1 1 4 5 5 5 3 Leucine rich repeat LRR_4 PF12799.2 ERZ98411.1 - 6.2e-13 48.0 0.9 2e-06 27.2 0.2 3.8 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ98411.1 - 3.4e-09 35.8 6.0 0.00024 20.8 0.0 6.0 6 0 0 6 6 6 1 Leucine Rich repeat LRR_1 PF00560.28 ERZ98411.1 - 1.4e-06 27.5 7.6 0.052 13.5 0.0 5.2 5 1 0 5 5 5 2 Leucine Rich Repeat F-box-like PF12937.2 ERZ98411.1 - 0.00015 21.3 0.3 0.00038 20.1 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_7 PF13504.1 ERZ98411.1 - 0.00031 20.4 6.1 0.41 11.0 0.0 5.3 4 2 0 4 4 4 1 Leucine rich repeat Glyco_hydro_4 PF02056.11 ERZ98411.1 - 0.011 15.0 0.0 0.77 9.0 0.0 2.3 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase AAA PF00004.24 ERZ98412.1 - 7.2e-06 26.2 0.1 0.017 15.3 0.0 4.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ98412.1 - 0.00022 21.3 0.0 0.058 13.5 0.0 3.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ERZ98412.1 - 0.00061 19.5 0.0 0.0078 15.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 ERZ98412.1 - 0.0019 17.8 0.0 0.057 13.0 0.0 3.2 3 0 0 3 3 3 1 NACHT domain ABC_tran PF00005.22 ERZ98412.1 - 0.0026 18.0 0.2 0.31 11.3 0.0 3.6 3 0 0 3 3 3 1 ABC transporter AAA_16 PF13191.1 ERZ98412.1 - 0.078 12.9 0.6 3.4 7.5 0.0 3.2 3 1 0 3 3 3 0 AAA ATPase domain AAA_28 PF13521.1 ERZ98412.1 - 0.78 9.6 0.0 1.9 8.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ERZ98412.1 - 1.1 8.5 0.0 7.1 5.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain CoatB PF10389.4 ERZ98413.1 - 0.0027 17.5 2.3 0.0048 16.7 1.6 1.3 1 0 0 1 1 1 1 Bacteriophage coat protein B Arrestin_C PF02752.17 ERZ98414.1 - 1.7e-18 67.0 0.1 2e-16 60.3 0.1 2.1 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ERZ98414.1 - 4.7e-14 52.4 0.0 4.7e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 ERZ98414.1 - 0.086 12.3 0.0 0.23 10.9 0.0 1.7 1 1 0 1 1 1 0 Arrestin_N terminal like IucA_IucC PF04183.7 ERZ98414.1 - 0.16 11.2 0.0 0.47 9.6 0.0 1.7 2 0 0 2 2 2 0 IucA / IucC family ATP-synt_E PF05680.7 ERZ98418.1 - 0.46 10.4 9.3 1.2 9.0 6.4 1.9 1 0 0 1 1 1 0 ATP synthase E chain K_channel_TID PF07941.6 ERZ98418.1 - 1.8 8.8 6.8 5 7.4 4.7 1.8 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain NARP1 PF12569.3 ERZ98418.1 - 7 5.2 15.2 13 4.3 10.5 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 NYN PF01936.13 ERZ98419.1 - 2.5e-05 24.5 0.0 4.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 NYN domain BCS1_N PF08740.6 ERZ98421.1 - 0.0054 16.3 0.0 53 3.3 0.0 4.9 5 0 0 5 5 5 0 BCS1 N terminal DUF4413 PF14372.1 ERZ98421.1 - 0.14 12.1 11.9 0.26 11.2 0.2 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) DUF4116 PF13475.1 ERZ98421.1 - 0.17 11.3 7.5 3.2 7.3 0.1 5.4 7 0 0 7 7 7 0 Domain of unknown function (DUF4116) JmjC PF02373.17 ERZ98422.1 - 4.6e-07 30.0 0.1 1.6e-05 25.1 0.1 2.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 ERZ98422.1 - 9e-07 28.6 1.9 1e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Cupin-like domain PHD PF00628.24 ERZ98422.1 - 1.5e-05 24.6 13.9 2.7e-05 23.7 9.7 1.5 1 0 0 1 1 1 1 PHD-finger DUF1423 PF07227.6 ERZ98422.1 - 0.0097 14.6 3.9 0.0097 14.6 2.7 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1423) C1_1 PF00130.17 ERZ98422.1 - 0.018 14.7 5.4 0.018 14.7 3.7 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.20 ERZ98423.1 - 3.8e-63 213.0 0.0 4.3e-63 212.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98423.1 - 4.5e-45 153.7 0.0 5.7e-45 153.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ98423.1 - 0.00031 20.5 0.0 0.26 11.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ98423.1 - 0.00033 19.7 0.1 0.00082 18.4 0.0 1.9 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 ERZ98423.1 - 0.0084 15.4 0.1 0.023 14.0 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 ERZ98424.1 - 2.3e-70 236.7 0.0 3.4e-69 232.9 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98424.1 - 2.8e-40 138.0 0.0 5.8e-40 137.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98424.1 - 1.5e-05 24.1 0.0 0.00011 21.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ98424.1 - 0.0032 17.2 0.4 0.0083 15.8 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ERZ98424.1 - 0.0065 15.3 0.2 0.014 14.2 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.17 ERZ98424.1 - 0.016 14.5 0.3 0.034 13.4 0.2 1.5 1 0 0 1 1 1 0 RIO1 family AcylCoA_dehyd_C PF12186.3 ERZ98424.1 - 0.052 13.4 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal BRCT PF00533.21 ERZ98425.1 - 0.00014 21.9 0.1 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF1681 PF07933.9 ERZ98426.1 - 3.1e-58 195.8 0.0 4e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) p47_phox_C PF08944.6 ERZ98426.1 - 0.049 13.8 1.9 0.14 12.3 0.1 2.4 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain AAA PF00004.24 ERZ98427.1 - 3.8e-32 111.2 0.0 1.1e-31 109.8 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 ERZ98427.1 - 3.7e-30 103.6 0.3 4e-29 100.2 0.1 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 ERZ98427.1 - 8.4e-24 83.2 5.6 8.4e-24 83.2 3.9 2.1 3 0 0 3 3 1 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 ERZ98427.1 - 2.2e-05 25.2 0.1 0.00017 22.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ERZ98427.1 - 6.9e-05 22.3 0.1 0.00019 20.8 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein TPR_1 PF00515.23 ERZ98427.1 - 7e-05 22.2 1.6 0.11 12.1 0.9 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat RNA_helicase PF00910.17 ERZ98427.1 - 0.00013 22.1 0.1 0.013 15.6 0.0 3.3 4 0 0 4 4 3 1 RNA helicase AAA_16 PF13191.1 ERZ98427.1 - 0.00022 21.2 0.0 0.0023 17.9 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ERZ98427.1 - 0.00023 21.3 0.2 0.011 15.8 0.0 2.8 2 1 0 3 3 3 1 AAA domain RuvB_N PF05496.7 ERZ98427.1 - 0.00026 20.0 0.0 0.00053 19.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ERZ98427.1 - 0.00031 19.7 0.0 0.00072 18.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 ERZ98427.1 - 0.00047 19.8 0.1 0.017 14.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 ERZ98427.1 - 0.00058 19.3 0.1 0.2 11.0 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ERZ98427.1 - 0.0028 17.5 0.9 0.012 15.5 0.0 2.4 3 0 0 3 3 2 1 AAA domain TPR_11 PF13414.1 ERZ98427.1 - 0.0069 16.0 1.1 0.17 11.5 0.6 2.6 2 0 0 2 2 2 1 TPR repeat AAA_33 PF13671.1 ERZ98427.1 - 0.0084 15.9 0.0 0.028 14.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ERZ98427.1 - 0.0086 16.3 0.2 0.031 14.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain PhoH PF02562.11 ERZ98427.1 - 0.0096 15.1 0.1 0.033 13.4 0.0 1.9 2 0 0 2 2 2 1 PhoH-like protein Arch_ATPase PF01637.13 ERZ98427.1 - 0.01 15.5 1.8 0.43 10.2 0.0 3.0 2 1 1 3 3 3 0 Archaeal ATPase TPR_8 PF13181.1 ERZ98427.1 - 0.013 15.2 8.7 0.017 14.8 1.9 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_19 PF13245.1 ERZ98427.1 - 0.016 14.9 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_24 PF13479.1 ERZ98427.1 - 0.022 14.3 2.0 0.076 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 ERZ98427.1 - 0.027 13.6 0.0 0.07 12.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 ERZ98427.1 - 0.035 13.7 0.0 0.41 10.2 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Parvo_NS1 PF01057.12 ERZ98427.1 - 0.053 12.3 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_2 PF07724.9 ERZ98427.1 - 0.053 13.4 0.2 3 7.7 0.0 2.8 2 1 0 2 2 1 0 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.1 ERZ98427.1 - 0.056 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain USP8_dimer PF08969.6 ERZ98427.1 - 0.057 13.3 7.6 0.12 12.2 5.3 1.5 1 0 0 1 1 1 0 USP8 dimerisation domain TIP49 PF06068.8 ERZ98427.1 - 0.089 11.4 0.0 0.21 10.2 0.0 1.6 1 0 0 1 1 1 0 TIP49 C-terminus AAA_21 PF13304.1 ERZ98427.1 - 0.58 10.0 3.4 3.6 7.4 0.0 2.9 2 1 1 3 3 3 0 AAA domain TPR_2 PF07719.12 ERZ98427.1 - 0.87 9.6 6.8 0.35 10.9 0.9 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat DnaJ PF00226.26 ERZ98429.1 - 1.4e-21 75.9 2.9 3.4e-21 74.7 2.0 1.7 1 0 0 1 1 1 1 DnaJ domain MCM PF00493.18 ERZ98430.1 - 8.9e-121 402.7 0.2 1.4e-120 402.0 0.1 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ERZ98430.1 - 2.6e-21 76.3 0.3 2.6e-21 76.3 0.2 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 ERZ98430.1 - 5.7e-08 32.1 0.1 1.6e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ERZ98430.1 - 0.0045 16.5 0.0 0.014 14.9 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Toxin_51 PF15531.1 ERZ98430.1 - 0.014 15.1 1.1 0.44 10.3 0.0 3.0 3 0 0 3 3 3 0 Putative toxin 51 DUF2087 PF09860.4 ERZ98430.1 - 0.068 12.9 0.1 0.4 10.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) FA_desaturase PF00487.19 ERZ98432.1 - 0.36 10.2 3.6 0.48 9.8 0.2 2.1 2 0 0 2 2 2 0 Fatty acid desaturase RGS PF00615.14 ERZ98433.1 - 3.9e-14 52.7 2.7 4.4e-14 52.5 1.9 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.6 ERZ98433.1 - 0.019 14.4 0.4 0.023 14.1 0.2 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain DUF2028 PF09667.5 ERZ98433.1 - 0.056 13.5 0.2 0.076 13.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) F-box-like PF12937.2 ERZ98434.1 - 6.7e-09 35.3 0.9 3.1e-07 30.0 0.6 2.4 2 1 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ98434.1 - 3.2e-06 26.6 1.0 9.3e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 F-box domain CTD PF12815.2 ERZ98437.1 - 0.026 14.9 0.9 0.057 13.8 0.6 1.5 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 ETRAMP PF09716.5 ERZ98440.1 - 0.023 14.6 0.2 0.027 14.4 0.1 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) MscS_TM PF12794.2 ERZ98440.1 - 0.025 13.2 0.0 0.028 13.0 0.0 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ATP-synt_8 PF00895.15 ERZ98440.1 - 0.06 13.5 2.8 0.076 13.2 1.9 1.4 1 1 0 1 1 1 0 ATP synthase protein 8 p450 PF00067.17 ERZ98442.1 - 2.3e-81 273.6 0.3 2.7e-81 273.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Leu_zip PF15294.1 ERZ98446.1 - 0.093 11.8 4.0 0.14 11.2 2.8 1.2 1 0 0 1 1 1 0 Leucine zipper Pkinase_Tyr PF07714.12 ERZ98447.1 - 2.3e-29 102.2 0.0 2.7e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98447.1 - 1.1e-26 93.5 0.0 1.3e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ98447.1 - 0.09 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2026 PF09641.5 ERZ98450.1 - 0.054 12.8 0.0 0.072 12.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2026) Myb_DNA-binding PF00249.26 ERZ98452.1 - 4.6e-06 26.5 0.1 6.2e-06 26.1 0.0 1.3 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ98452.1 - 2.3e-05 24.3 0.1 2.7e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ERZ98452.1 - 0.00046 20.2 0.9 0.0041 17.2 0.2 1.9 1 1 1 2 2 2 1 Myb/SANT-like DNA-binding domain Sel1 PF08238.7 ERZ98453.1 - 1.1e-76 251.5 27.1 5.3e-10 39.6 0.4 9.0 9 0 0 9 9 9 8 Sel1 repeat TPR_17 PF13431.1 ERZ98453.1 - 4.5e-06 26.4 9.5 13 6.2 0.0 7.9 9 0 0 9 9 9 1 Tetratricopeptide repeat Guanylate_cyc PF00211.15 ERZ98453.1 - 0.02 14.2 0.4 4 6.7 0.0 2.5 1 1 1 2 2 2 0 Adenylate and Guanylate cyclase catalytic domain RQC PF09382.5 ERZ98453.1 - 0.034 13.8 1.9 17 5.2 0.0 4.3 2 2 4 6 6 6 0 RQC domain HTH_16 PF12645.2 ERZ98453.1 - 0.11 12.4 14.7 4.9 7.1 0.0 6.4 7 0 0 7 7 7 0 Helix-turn-helix domain SnoaL_3 PF13474.1 ERZ98453.1 - 0.14 12.2 3.2 33 4.5 0.0 4.5 4 2 2 6 6 6 0 SnoaL-like domain TPR_5 PF12688.2 ERZ98453.1 - 0.43 10.6 17.2 75 3.3 0.1 7.2 4 2 4 8 8 8 0 Tetratrico peptide repeat Phage_terminase PF10668.4 ERZ98453.1 - 9.5 6.0 15.6 41 4.0 0.1 6.4 7 1 1 8 8 8 0 Phage terminase small subunit Pkinase PF00069.20 ERZ98455.1 - 1.8e-09 37.1 0.3 2.9e-09 36.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98455.1 - 2e-07 30.3 0.0 2.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RVT_1 PF00078.22 ERZ98458.1 - 0.1 11.9 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) HLH PF00010.21 ERZ98459.1 - 6.5e-14 51.3 0.7 1.7e-13 50.0 0.5 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HALZ PF02183.13 ERZ98459.1 - 0.0087 15.7 0.6 0.022 14.4 0.4 1.6 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF3694 PF12473.3 ERZ98460.1 - 2.8e-39 133.9 0.0 7.1e-39 132.6 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein PH PF00169.24 ERZ98460.1 - 2.6e-16 59.7 0.3 1.2e-15 57.6 0.2 2.2 1 0 0 1 1 1 1 PH domain Kinesin PF00225.18 ERZ98460.1 - 4.6e-12 45.3 0.0 9.5e-12 44.2 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain KIF1B PF12423.3 ERZ98460.1 - 2.6e-08 33.7 0.1 6.9e-08 32.4 0.1 1.8 1 0 0 1 1 1 1 Kinesin protein 1B PH_11 PF15413.1 ERZ98460.1 - 0.00017 21.7 1.1 0.0014 18.8 0.8 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.1 ERZ98460.1 - 0.00054 20.1 0.2 0.0024 18.0 0.1 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain FlxA PF14282.1 ERZ98460.1 - 0.0018 18.2 15.7 0.0018 18.2 10.9 2.8 2 0 0 2 2 2 1 FlxA-like protein OmpH PF03938.9 ERZ98460.1 - 0.0066 16.4 15.5 0.0066 16.4 10.7 2.8 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) AAA_23 PF13476.1 ERZ98460.1 - 0.35 11.1 16.3 0.21 11.8 3.2 2.8 2 0 0 2 2 2 0 AAA domain UPF0270 PF06794.7 ERZ98461.1 - 0.044 13.5 0.5 0.07 12.8 0.2 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0270) CLAG PF03805.8 ERZ98461.1 - 0.046 11.0 0.3 0.05 10.9 0.2 1.2 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein EVE PF01878.13 ERZ98461.1 - 0.048 13.6 0.7 0.068 13.1 0.4 1.4 1 1 0 1 1 1 0 EVE domain Ribosomal_L35Ae PF01247.13 ERZ98461.1 - 0.12 12.1 0.3 0.15 11.8 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L35Ae NARP1 PF12569.3 ERZ98463.1 - 7.3e-193 642.0 22.1 7.3e-193 642.0 15.3 2.7 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.12 ERZ98463.1 - 6.9e-19 66.1 27.5 5.1e-05 22.8 0.1 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ98463.1 - 2.6e-17 62.9 8.7 0.099 13.3 0.0 7.5 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ98463.1 - 1e-15 56.7 1.5 0.075 13.7 0.0 9.5 9 2 1 10 10 10 3 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ98463.1 - 1.3e-15 56.7 27.9 5.1e-06 26.0 0.5 7.9 8 0 0 8 8 8 4 TPR repeat TPR_19 PF14559.1 ERZ98463.1 - 5.1e-14 52.3 15.5 0.0023 18.2 0.1 7.3 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ98463.1 - 1.2e-09 37.9 19.2 0.034 14.0 0.1 7.5 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ98463.1 - 4.2e-08 32.4 27.5 0.00036 20.0 0.3 8.9 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ98463.1 - 2.1e-06 27.4 1.8 0.75 9.6 0.1 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ98463.1 - 1.5e-05 24.4 24.1 0.0019 17.8 0.1 8.4 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ98463.1 - 1.5e-05 25.1 11.9 7.6 7.2 0.1 9.0 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ98463.1 - 4e-05 23.0 7.6 0.34 10.8 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 ERZ98463.1 - 0.0006 18.9 4.7 0.0032 16.5 0.3 3.4 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ98463.1 - 0.0051 16.9 18.9 0.2 11.9 0.0 7.7 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ98463.1 - 0.025 14.4 5.5 11 6.0 0.0 6.1 8 0 0 8 8 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ERZ98463.1 - 0.31 10.9 12.8 0.95 9.3 0.2 4.8 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ThiF PF00899.16 ERZ98464.1 - 1.5e-27 96.0 0.0 3.4e-27 94.9 0.0 1.7 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 ERZ98464.1 - 0.0092 16.0 0.0 0.029 14.4 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pribosyltran_N PF13793.1 ERZ98465.1 - 9.9e-39 131.6 0.5 9.9e-37 125.2 0.0 2.6 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ERZ98465.1 - 2.4e-38 131.7 6.5 2.9e-31 108.6 2.3 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ERZ98465.1 - 9.5e-12 44.7 1.1 2.5e-11 43.3 0.2 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain PRTase_3 PF15610.1 ERZ98465.1 - 0.016 14.1 0.1 0.024 13.5 0.1 1.2 1 0 0 1 1 1 0 PRTase ComF-like UPRTase PF14681.1 ERZ98465.1 - 0.026 13.7 1.1 0.055 12.6 0.3 1.7 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase Cation_efflux PF01545.16 ERZ98466.1 - 3e-69 233.2 11.3 3.5e-69 233.0 7.8 1.0 1 0 0 1 1 1 1 Cation efflux family DUF1212 PF06738.7 ERZ98466.1 - 5.7 6.3 8.8 4.9 6.5 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1212) Beta_elim_lyase PF01212.16 ERZ98467.1 - 1.3e-67 227.9 0.0 1.7e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 ERZ98467.1 - 2.9e-05 23.2 0.0 4.9e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 ERZ98467.1 - 0.0031 16.6 0.0 0.18 10.7 0.0 2.6 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF692 PF05114.8 ERZ98467.1 - 0.016 14.1 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF692) WXG100 PF06013.7 ERZ98470.1 - 0.045 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Proteins of 100 residues with WXG Sds3 PF08598.6 ERZ98473.1 - 1.3e-22 80.3 18.7 1.3e-22 80.3 13.0 2.0 1 1 1 2 2 2 1 Sds3-like UMP1 PF05348.6 ERZ98473.1 - 0.034 14.1 0.1 0.099 12.6 0.1 1.9 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 PAP_central PF04928.12 ERZ98473.1 - 0.13 11.0 1.1 0.16 10.7 0.8 1.2 1 0 0 1 1 1 0 Poly(A) polymerase central domain ALS_ss_C PF10369.4 ERZ98475.1 - 0.063 12.9 0.0 0.82 9.4 0.0 2.2 1 1 2 3 3 3 0 Small subunit of acetolactate synthase DUF1645 PF07816.6 ERZ98479.1 - 0.088 13.2 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) DUF3507 PF12015.3 ERZ98480.1 - 0.066 12.7 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) G_glu_transpept PF01019.16 ERZ98481.1 - 1e-86 291.4 0.0 1.2e-86 291.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Asparaginase_2 PF01112.13 ERZ98481.1 - 0.031 12.9 0.1 0.045 12.4 0.0 1.2 1 0 0 1 1 1 0 Asparaginase 2OG-FeII_Oxy_2 PF13532.1 ERZ98482.1 - 0.074 12.8 0.1 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily TF_Zn_Ribbon PF08271.7 ERZ98483.1 - 0.33 10.3 2.7 0.99 8.7 1.9 1.8 1 1 0 1 1 1 0 TFIIB zinc-binding Ogr_Delta PF04606.7 ERZ98483.1 - 1.6 8.4 4.7 5.9 6.6 0.4 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-ribbon_3 PF13248.1 ERZ98483.1 - 4 6.7 8.9 0.22 10.8 0.6 2.6 2 1 1 3 3 3 0 zinc-ribbon domain DUF1610 PF07754.6 ERZ98483.1 - 6.4 7.0 8.5 4.9 7.3 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) Fanconi_C PF02106.10 ERZ98485.1 - 0.083 11.3 0.0 0.1 11.0 0.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia group C protein SPT2 PF08243.6 ERZ98487.1 - 0.021 15.0 0.6 0.039 14.2 0.4 1.4 1 0 0 1 1 1 0 SPT2 chromatin protein DDE_1 PF03184.14 ERZ98488.1 - 2.8e-37 127.9 0.1 6.3e-37 126.8 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease CENP-B_N PF04218.8 ERZ98488.1 - 5e-09 35.4 3.0 1e-08 34.4 0.8 2.4 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.11 ERZ98488.1 - 6.5e-07 29.0 1.9 3.1e-06 26.8 0.2 2.5 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_Tnp_1 PF01527.15 ERZ98488.1 - 0.00023 21.0 2.6 0.00048 20.0 0.2 2.3 1 1 1 2 2 2 1 Transposase HTH_28 PF13518.1 ERZ98488.1 - 0.00082 19.3 0.1 0.0032 17.4 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain BrkDBD PF09607.5 ERZ98488.1 - 0.0027 17.2 4.4 0.0029 17.1 1.1 2.3 2 0 0 2 2 2 1 Brinker DNA-binding domain HTH_23 PF13384.1 ERZ98488.1 - 0.01 15.4 0.6 0.064 12.9 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain DUF1869 PF08956.5 ERZ98488.1 - 0.042 13.4 0.0 0.098 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) HTH_Tnp_IS630 PF01710.11 ERZ98488.1 - 0.079 12.6 0.9 0.27 10.9 0.3 2.0 2 0 0 2 2 2 0 Transposase Melittin PF01372.12 ERZ98488.1 - 1.2 8.6 4.1 0.94 8.8 0.0 2.9 3 0 0 3 3 3 0 Melittin C2 PF00168.25 ERZ98489.1 - 1.1e-13 50.8 0.0 1.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 C2 domain DUF1985 PF09331.6 ERZ98491.1 - 0.026 14.3 1.4 0.24 11.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1985) HSCB_C PF07743.8 ERZ98491.1 - 0.48 10.9 3.7 0.49 10.8 0.1 2.4 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain Kinetocho_Slk19 PF12709.2 ERZ98491.1 - 0.77 9.8 5.8 0.28 11.2 0.3 2.4 2 0 0 2 2 2 0 Central kinetochore-associated DUF3384 PF11864.3 ERZ98492.1 - 0.095 11.1 0.9 0.1 11.0 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) CENP-R PF06729.7 ERZ98493.1 - 0.22 11.1 2.9 0.74 9.4 0.7 2.0 2 0 0 2 2 2 0 Kinetochore component, CENP-R Myb_DNA-bind_6 PF13921.1 ERZ98498.1 - 4.4e-05 23.4 1.1 0.00014 21.8 0.0 2.1 2 1 0 2 2 2 1 Myb-like DNA-binding domain Sulfotransfer_1 PF00685.22 ERZ98498.1 - 0.018 14.3 0.8 3.3 6.8 0.2 2.0 1 1 1 2 2 2 0 Sulfotransferase domain Myb_DNA-binding PF00249.26 ERZ98498.1 - 0.14 12.2 1.3 3.8 7.6 0.0 2.7 2 2 0 2 2 2 0 Myb-like DNA-binding domain Nup35_RRM PF05172.8 ERZ98498.1 - 0.19 11.5 0.7 0.38 10.5 0.4 1.7 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.20 ERZ98500.1 - 9e-25 87.2 0.0 9.7e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98500.1 - 2.1e-21 76.1 0.0 2.2e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase PsbU PF06514.6 ERZ98500.1 - 0.0006 19.6 0.0 0.00094 18.9 0.0 1.4 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) APH PF01636.18 ERZ98500.1 - 0.039 13.6 0.0 0.8 9.3 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ras PF00071.17 ERZ98501.1 - 3.3e-46 156.6 0.0 3.8e-46 156.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ98501.1 - 5.8e-12 46.1 0.0 8.1e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ERZ98501.1 - 1.1e-09 37.7 0.0 1.4e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Pkinase_Tyr PF07714.12 ERZ98502.1 - 1.4e-23 83.2 0.0 2.6e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98502.1 - 5.5e-19 68.3 1.6 1.5e-18 66.9 1.1 1.8 1 1 0 1 1 1 1 Protein kinase domain RE_HindVP PF09519.5 ERZ98502.1 - 0.0088 14.9 0.2 0.012 14.4 0.1 1.2 1 0 0 1 1 1 1 HindVP restriction endonuclease APH PF01636.18 ERZ98502.1 - 0.049 13.3 0.1 0.89 9.2 0.5 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Stc1 PF12898.2 ERZ98502.1 - 0.35 10.9 4.2 0.24 11.4 1.4 1.9 2 0 0 2 2 2 0 Stc1 domain ZZ PF00569.12 ERZ98503.1 - 6e-05 22.4 5.8 6e-05 22.4 4.0 2.9 2 1 0 2 2 2 1 Zinc finger, ZZ type DUF2197 PF09963.4 ERZ98503.1 - 3.3 7.7 9.0 1.2 9.1 1.2 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-CXXC PF02008.15 ERZ98503.1 - 8.4 6.2 18.6 2.7 7.8 4.1 2.2 2 0 0 2 2 2 0 CXXC zinc finger domain Sel1 PF08238.7 ERZ98504.1 - 3.5e-113 367.5 66.3 8.1e-11 42.1 0.3 15.2 14 1 1 15 15 15 15 Sel1 repeat ImmE5 PF11480.3 ERZ98504.1 - 0.49 10.2 4.2 6.7 6.5 0.0 4.4 4 2 2 6 6 6 0 Colicin-E5 Imm protein C2 PF00168.25 ERZ98505.1 - 5.5e-11 42.1 0.3 9.7e-11 41.3 0.2 1.4 1 0 0 1 1 1 1 C2 domain Sel1 PF08238.7 ERZ98507.1 - 6.5e-43 144.2 11.8 2.5e-09 37.4 0.5 5.8 6 0 0 6 6 6 5 Sel1 repeat TPR_20 PF14561.1 ERZ98507.1 - 0.0038 17.2 1.5 0.38 10.8 0.1 3.0 2 2 1 3 3 3 1 Tetratricopeptide repeat DUF2235 PF09994.4 ERZ98507.1 - 0.0069 15.7 0.1 2.4 7.4 0.0 2.9 1 1 2 3 3 3 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_6 PF13174.1 ERZ98507.1 - 0.03 14.7 12.0 8.8 7.0 0.1 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF2989 PF11207.3 ERZ98507.1 - 0.053 12.9 4.7 0.18 11.2 0.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2989) PRD PF00874.15 ERZ98507.1 - 0.52 10.4 2.8 9.4 6.4 0.1 3.1 1 1 1 3 3 3 0 PRD domain Gly_rich PF12810.2 ERZ98508.1 - 0.023 14.3 0.2 0.039 13.5 0.1 1.3 1 1 0 1 1 1 0 Glycine rich protein Cation_ATPase_C PF00689.16 ERZ98509.1 - 1.5e-08 34.4 14.4 1.5e-08 34.4 10.0 2.1 1 1 1 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ERZ98509.1 - 0.008 16.6 0.0 0.017 15.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Integrin_b_cyt PF08725.6 ERZ98509.1 - 0.0091 15.3 0.4 0.019 14.3 0.3 1.5 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain PI-PLC-X PF00388.14 ERZ98509.1 - 0.045 13.1 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF4042 PF13251.1 ERZ98511.1 - 6e-42 143.1 4.5 7.6e-42 142.8 0.7 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF4042) HEAT_2 PF13646.1 ERZ98511.1 - 2.6e-14 53.2 0.1 0.0099 16.1 0.0 6.6 4 2 4 8 8 8 6 HEAT repeats HEAT_EZ PF13513.1 ERZ98511.1 - 5.2e-12 45.8 3.5 0.071 13.6 0.0 7.8 7 1 1 8 8 8 4 HEAT-like repeat HEAT PF02985.17 ERZ98511.1 - 2e-08 33.5 15.4 1.1 9.5 0.0 10.1 11 0 0 11 11 11 2 HEAT repeat Arm PF00514.18 ERZ98511.1 - 7.8e-06 25.5 4.4 5.9 6.8 0.0 5.8 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.3 ERZ98511.1 - 0.075 12.9 2.3 8.2 6.3 0.0 4.2 5 0 0 5 5 5 0 V-ATPase subunit H BTB PF00651.26 ERZ98512.1 - 3.3e-15 56.0 0.0 6.2e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ98512.1 - 2.1e-08 34.2 0.1 4.1e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ98512.1 - 4.7e-06 26.3 0.1 4.7e-05 23.1 0.0 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch TMF_DNA_bd PF12329.3 ERZ98513.1 - 0.042 13.6 3.5 0.08 12.7 2.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 ERZ98513.1 - 0.25 11.7 1.9 0.67 10.3 1.3 1.7 1 0 0 1 1 1 0 SlyX DivIVA PF05103.8 ERZ98513.1 - 0.34 10.9 4.8 0.56 10.2 2.6 1.7 2 0 0 2 2 2 0 DivIVA protein DUF2572 PF10833.3 ERZ98514.1 - 0.0077 15.6 0.1 0.02 14.2 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2572) VirB3 PF05101.8 ERZ98514.1 - 0.025 14.5 0.1 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Myb_DNA-bind_4 PF13837.1 ERZ98515.1 - 3.6e-07 30.2 2.0 3.6e-07 30.2 1.4 1.6 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ERZ98515.1 - 5.1e-05 23.0 1.5 0.00013 21.7 1.0 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Dec-1 PF04624.9 ERZ98515.1 - 0.063 12.9 0.6 0.1 12.2 0.4 1.3 1 0 0 1 1 1 0 Dec-1 repeat MADF_DNA_bdg PF10545.4 ERZ98515.1 - 0.13 12.4 0.7 0.29 11.3 0.5 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like F-box-like PF12937.2 ERZ98518.1 - 0.00036 20.1 2.0 0.00067 19.3 0.5 2.2 2 0 0 2 2 2 1 F-box-like HEAT_2 PF13646.1 ERZ98519.1 - 2.1e-32 111.2 0.1 2.9e-16 59.5 0.0 3.1 1 1 2 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 ERZ98519.1 - 1.9e-21 74.2 0.0 0.0001 22.4 0.0 4.4 4 0 0 4 4 4 4 PBS lyase HEAT-like repeat HEAT PF02985.17 ERZ98519.1 - 4.6e-07 29.3 0.7 0.76 10.0 0.0 4.7 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 ERZ98519.1 - 1.3e-05 25.4 0.2 0.016 15.6 0.0 4.0 2 1 1 3 3 3 2 HEAT-like repeat Cohesin_HEAT PF12765.2 ERZ98519.1 - 0.021 14.7 0.0 0.6 10.1 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Arm PF00514.18 ERZ98519.1 - 0.041 13.7 0.1 0.56 10.1 0.0 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat BAR PF03114.13 ERZ98520.1 - 4.5e-42 144.1 3.1 5.8e-42 143.7 2.2 1.0 1 0 0 1 1 1 1 BAR domain AAA_13 PF13166.1 ERZ98520.1 - 0.0075 14.7 1.7 0.0091 14.5 1.2 1.2 1 0 0 1 1 1 1 AAA domain TBCA PF02970.11 ERZ98520.1 - 0.017 15.1 3.3 0.17 12.0 0.2 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor A Tropomyosin PF00261.15 ERZ98520.1 - 0.083 11.9 4.1 0.55 9.2 0.2 2.3 2 0 0 2 2 2 0 Tropomyosin DUF3445 PF11927.3 ERZ98520.1 - 0.084 12.2 0.2 0.18 11.1 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3445) Syntaxin_2 PF14523.1 ERZ98520.1 - 0.11 12.5 0.5 0.77 9.8 0.1 2.3 2 0 0 2 2 2 0 Syntaxin-like protein GAS PF13851.1 ERZ98520.1 - 0.37 9.9 5.6 1.1 8.3 0.4 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Arfaptin PF06456.8 ERZ98520.1 - 1.3 8.2 4.3 8.6 5.6 3.0 2.0 1 1 0 1 1 1 0 Arfaptin-like domain PCI PF01399.22 ERZ98521.1 - 3.5e-07 30.4 1.4 4.3e-07 30.1 0.1 1.7 2 1 0 2 2 2 1 PCI domain MFS_1 PF07690.11 ERZ98522.1 - 1.1e-54 185.4 54.9 1.1e-40 139.4 16.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 ERZ98522.1 - 3.6e-11 41.9 16.1 6.5e-06 24.5 2.0 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector Skp1 PF01466.14 ERZ98523.1 - 1.2e-39 134.1 1.4 1.8e-39 133.6 0.9 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 ERZ98523.1 - 5.9e-24 83.9 0.0 1.7e-23 82.4 0.0 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain RBM39linker PF15519.1 ERZ98523.1 - 0.08 13.2 0.6 0.88 9.8 0.0 2.2 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF3546 PF12066.3 ERZ98524.1 - 6.1e-22 77.7 10.6 6.1e-22 77.7 7.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF1777 PF08648.7 ERZ98524.1 - 0.68 9.6 41.3 1.8 8.2 28.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) F-box-like PF12937.2 ERZ98525.1 - 4.3e-05 23.1 1.9 8.3e-05 22.2 1.3 1.5 1 1 0 1 1 1 1 F-box-like Sel1 PF08238.7 ERZ98526.1 - 1.1e-117 381.8 33.7 1.3e-11 44.7 0.5 14.1 13 1 1 14 14 14 14 Sel1 repeat MIT PF04212.13 ERZ98526.1 - 4.3e-11 42.5 29.3 0.13 12.1 0.1 8.9 8 1 0 8 8 8 5 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ERZ98526.1 - 0.0011 18.6 4.6 13 5.8 0.0 7.2 6 1 2 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ98526.1 - 0.0066 16.8 22.1 35 5.1 0.0 10.6 13 0 0 13 13 13 0 Tetratricopeptide repeat Trefoil PF00088.13 ERZ98526.1 - 0.17 11.5 14.8 19 4.9 0.1 5.3 5 0 0 5 5 5 0 Trefoil (P-type) domain DUF2182 PF09948.4 ERZ98526.1 - 1.7 8.4 7.1 43 3.9 0.0 4.3 4 1 1 5 5 5 0 Predicted metal-binding integral membrane protein (DUF2182) DUF3797 PF12677.2 ERZ98527.1 - 0.12 12.0 0.7 0.23 11.1 0.4 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) MULE PF10551.4 ERZ98528.1 - 1.2e-05 25.4 0.0 3.1e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 MULE transposase domain DUF4123 PF13503.1 ERZ98528.1 - 0.034 14.1 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) Herpes_Helicase PF02689.9 ERZ98533.1 - 0.0097 13.7 0.0 0.0099 13.6 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ERZ98533.1 - 0.023 14.8 0.1 0.042 14.0 0.0 1.4 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain Actin PF00022.14 ERZ98534.1 - 6.3e-162 538.4 0.0 7.1e-162 538.3 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 ERZ98534.1 - 0.069 13.5 0.0 0.19 12.1 0.0 1.7 1 1 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Lactamase_B_2 PF12706.2 ERZ98536.1 - 2.7e-09 36.8 0.2 5.1e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ERZ98536.1 - 3.9e-07 29.9 0.1 6e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily F-box-like PF12937.2 ERZ98538.1 - 3.6e-05 23.3 0.8 9.2e-05 22.0 0.6 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ERZ98538.1 - 0.00036 20.2 4.0 0.0041 16.8 0.7 2.9 2 1 0 2 2 2 1 Leucine rich repeat ESPR PF13018.1 ERZ98538.1 - 1.8 8.2 6.7 0.33 10.6 1.3 2.3 2 0 0 2 2 2 0 Extended Signal Peptide of Type V secretion system LRR_4 PF12799.2 ERZ98538.1 - 2.4 7.9 8.1 0.11 12.1 0.8 2.6 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) zf-CCHC PF00098.18 ERZ98539.1 - 0.0018 18.1 1.2 0.0025 17.6 0.4 1.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.1 ERZ98539.1 - 0.048 13.1 0.3 0.08 12.4 0.2 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Cauli_AT PF03233.8 ERZ98539.1 - 0.063 12.9 1.0 0.11 12.2 0.3 1.6 1 1 0 1 1 1 0 Aphid transmission protein zf-CCHC_2 PF13696.1 ERZ98539.1 - 0.079 12.4 1.7 0.092 12.2 0.2 1.8 2 0 0 2 2 2 0 Zinc knuckle RdRP PF05183.7 ERZ98540.1 - 8.3e-10 37.9 0.0 3.2e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 RNA dependent RNA polymerase Neurensin PF14927.1 ERZ98542.1 - 0.065 12.6 0.0 0.077 12.3 0.0 1.4 1 1 0 1 1 1 0 Neurensin Nucleoplasmin PF03066.10 ERZ98542.1 - 0.51 9.8 5.2 0.61 9.5 3.6 1.2 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 ERZ98542.1 - 2.3 7.4 7.5 2.4 7.3 5.2 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.1 ERZ98542.1 - 6.7 7.1 9.9 21 5.5 6.4 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Chibby PF14645.1 ERZ98543.1 - 0.018 14.9 0.4 0.044 13.6 0.0 1.8 2 0 0 2 2 2 0 Chibby family Zn_ribbon_2 PF12674.2 ERZ98543.1 - 0.019 15.2 0.1 0.068 13.5 0.1 1.9 1 0 0 1 1 1 0 Putative zinc ribbon domain Claudin_3 PF06653.6 ERZ98544.1 - 0.043 13.5 1.0 0.088 12.5 0.7 1.5 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Pkinase PF00069.20 ERZ98545.1 - 6.8e-37 127.0 0.4 8.1e-37 126.7 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98545.1 - 1.2e-33 116.2 0.0 1.5e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ98545.1 - 0.0004 20.1 0.7 0.00074 19.3 0.5 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ98545.1 - 0.00062 19.1 0.0 0.00093 18.5 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ98545.1 - 0.022 13.7 0.0 0.033 13.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like WaaY PF06176.6 ERZ98545.1 - 0.028 13.6 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ERZ98545.1 - 0.033 13.2 0.1 0.054 12.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KcnmB2_inactiv PF09303.5 ERZ98545.1 - 0.065 13.0 0.9 12 5.8 0.1 2.4 2 0 0 2 2 2 0 KCNMB2, ball and chain domain PFEMP PF03011.10 ERZ98546.1 - 0.26 11.6 7.4 0.47 10.8 5.2 1.3 1 0 0 1 1 1 0 PFEMP DBL domain Phage_terminase PF10668.4 ERZ98547.1 - 0.042 13.6 1.5 0.055 13.2 1.0 1.4 1 1 0 1 1 1 0 Phage terminase small subunit PFEMP PF03011.10 ERZ98548.1 - 0.00062 20.1 8.7 0.00088 19.6 6.0 1.2 1 0 0 1 1 1 1 PFEMP DBL domain Gcd10p PF04189.8 ERZ98548.1 - 1.3 8.1 9.6 2.4 7.2 6.6 1.6 1 1 0 1 1 1 0 Gcd10p family DUF3591 PF12157.3 ERZ98550.1 - 2.3e-147 491.1 4.3 3.4e-147 490.5 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) TBP-binding PF09247.6 ERZ98550.1 - 3.3e-05 24.0 0.2 0.00011 22.3 0.1 1.9 1 0 0 1 1 1 1 TATA box-binding protein binding Pkinase_Tyr PF07714.12 ERZ98551.1 - 1.5e-54 184.8 0.0 2.2e-54 184.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98551.1 - 1.7e-45 155.2 0.1 2.7e-45 154.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ98551.1 - 3.8e-07 30.5 0.6 0.044 14.4 0.0 2.6 2 0 0 2 2 2 2 Sel1 repeat RIO1 PF01163.17 ERZ98551.1 - 0.00085 18.7 0.3 0.002 17.5 0.2 1.6 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ98551.1 - 0.0038 16.3 0.0 0.0072 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ98551.1 - 0.012 15.3 0.0 0.43 10.2 0.3 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family BTB PF00651.26 ERZ98552.1 - 2.2e-18 66.2 0.0 4.8e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ98552.1 - 2.2e-08 34.1 1.4 5.2e-08 32.9 0.2 2.1 2 0 0 2 2 2 1 TLD P16-Arc PF04699.9 ERZ98552.1 - 0.00039 20.4 0.3 0.27 11.2 0.0 2.3 2 0 0 2 2 2 2 ARP2/3 complex 16 kDa subunit (p16-Arc) BACK PF07707.10 ERZ98552.1 - 0.00083 19.1 0.5 0.011 15.5 0.1 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ERZ98552.1 - 0.012 14.6 0.0 0.028 13.4 0.0 1.6 1 1 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF2513 PF10711.4 ERZ98552.1 - 0.058 13.4 0.2 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) Sel1 PF08238.7 ERZ98553.1 - 3.9e-186 599.4 82.1 2.7e-11 43.7 0.2 21.1 21 0 0 21 21 21 20 Sel1 repeat TPR_6 PF13174.1 ERZ98553.1 - 3.3e-10 39.7 15.8 3.6 8.2 0.0 12.1 12 1 0 12 12 12 3 Tetratricopeptide repeat Phage_Nu1 PF07471.7 ERZ98553.1 - 0.064 12.7 6.4 1.3 8.4 0.2 3.7 4 0 0 4 4 4 0 Phage DNA packaging protein Nu1 Pkinase PF00069.20 ERZ98555.1 - 6.3e-71 238.5 0.0 8.1e-71 238.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98555.1 - 7.1e-32 110.4 0.0 9.9e-32 110.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 ERZ98555.1 - 9.6e-08 32.4 2.3 2.1e-07 31.3 1.6 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 ERZ98555.1 - 1.9e-07 30.3 0.0 1.5e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like C2 PF00168.25 ERZ98555.1 - 0.0005 19.8 0.2 0.0025 17.6 0.1 2.1 1 1 0 1 1 1 1 C2 domain Kdo PF06293.9 ERZ98555.1 - 0.0024 16.9 0.0 0.0046 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ98555.1 - 0.008 15.9 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Aft1_HRA PF11786.3 ERZ98555.1 - 0.14 12.4 0.4 0.33 11.2 0.3 1.6 1 0 0 1 1 1 0 Aft1 HRA domain KIAA1430 PF13879.1 ERZ98556.1 - 0.057 13.8 0.2 0.06 13.7 0.1 1.1 1 0 0 1 1 1 0 KIAA1430 homologue DUF1201 PF06716.6 ERZ98557.1 - 0.72 9.7 3.0 0.85 9.4 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1201) NKWYS PF10364.4 ERZ98559.1 - 0.00035 20.3 0.6 0.00037 20.2 0.4 1.0 1 0 0 1 1 1 1 Putative capsular polysaccharide synthesis protein Mit_ribos_Mrp51 PF11709.3 ERZ98560.1 - 0.06 12.5 0.3 2.7 7.1 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit MOZART1 PF12554.3 ERZ98561.1 - 2.3e-27 94.1 1.6 2.7e-27 93.9 1.1 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated PolyG_pol PF01518.11 ERZ98561.1 - 0.12 10.7 0.0 0.12 10.7 0.0 1.0 1 0 0 1 1 1 0 Sigma NS protein Pkinase_Tyr PF07714.12 ERZ98563.1 - 0.0018 17.3 0.1 0.0051 15.9 0.0 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase Ax_dynein_light PF10211.4 ERZ98563.1 - 0.24 11.2 4.0 1.2 8.9 0.0 2.6 1 1 2 3 3 3 0 Axonemal dynein light chain DUF904 PF06005.7 ERZ98563.1 - 0.56 10.5 6.6 0.14 12.5 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF904) HPD PF05044.7 ERZ98563.1 - 2.9 7.5 7.8 1 9.0 0.5 2.7 1 1 2 3 3 3 0 Homeo-prospero domain Eaf7 PF07904.8 ERZ98563.1 - 9.6 6.2 10.0 6.7 6.7 3.8 2.2 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 SDH_alpha PF03313.10 ERZ98565.1 - 5.8e-98 327.4 6.5 7.8e-98 326.9 4.5 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.10 ERZ98565.1 - 2.4e-55 186.9 0.0 5.6e-55 185.7 0.0 1.6 1 0 0 1 1 1 1 Serine dehydratase beta chain ATG22 PF11700.3 ERZ98566.1 - 1.7e-153 511.5 23.3 1.9e-153 511.3 16.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 ERZ98566.1 - 2.4e-08 33.1 48.5 6.9e-05 21.7 3.4 3.3 2 1 1 3 3 3 3 Major Facilitator Superfamily IncA PF04156.9 ERZ98566.1 - 0.042 13.4 0.0 0.042 13.4 0.0 3.0 3 0 0 3 3 3 0 IncA protein zf-RING_2 PF13639.1 ERZ98567.1 - 5.8e-10 38.8 13.9 9.7e-10 38.1 9.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ERZ98567.1 - 1.4e-08 34.2 12.7 2.9e-08 33.2 8.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ERZ98567.1 - 2.9e-07 30.4 14.3 5.1e-07 29.6 9.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ98567.1 - 5.8e-07 29.1 11.2 1.1e-06 28.2 7.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ERZ98567.1 - 6.9e-07 28.8 8.8 1.2e-06 28.0 6.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ERZ98567.1 - 4e-05 23.6 9.8 0.00011 22.2 6.7 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 ERZ98567.1 - 0.0046 16.7 4.3 0.0089 15.7 3.0 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein MRP-S33 PF08293.6 ERZ98567.1 - 0.085 12.8 0.3 2.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal subunit S27 zf-RING_UBOX PF13445.1 ERZ98567.1 - 0.087 12.5 7.5 0.23 11.1 5.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ERZ98567.1 - 0.11 12.3 16.5 0.28 11.0 11.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF836 PF05768.9 ERZ98567.1 - 0.13 12.5 2.2 0.27 11.5 0.1 2.4 2 1 0 2 2 2 0 Glutaredoxin-like domain (DUF836) zf-Apc11 PF12861.2 ERZ98567.1 - 1.7 8.5 7.9 4 7.3 5.5 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Ribosomal_S4e PF00900.15 ERZ98568.1 - 0.68 9.6 5.4 7.6 6.2 0.0 2.7 3 0 0 3 3 3 0 Ribosomal family S4e HATPase_c_3 PF13589.1 ERZ98570.1 - 1.8e-07 30.9 0.0 2.3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ERZ98570.1 - 3.9e-05 23.3 0.0 5.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ins145_P3_rec PF08709.6 ERZ98571.1 - 1.5e-06 27.3 0.0 2.5e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ERZ98571.1 - 0.0015 18.0 0.3 0.0039 16.7 0.1 1.8 2 0 0 2 2 2 1 MIR domain DUF3850 PF12961.2 ERZ98572.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3850) RIO1 PF01163.17 ERZ98573.1 - 9.6e-29 100.0 0.4 1.6e-28 99.3 0.2 1.4 1 0 0 1 1 1 1 RIO1 family CDC45 PF02724.9 ERZ98573.1 - 0.013 13.5 6.5 0.019 13.0 4.5 1.3 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.1 ERZ98573.1 - 0.016 15.4 3.8 0.052 13.8 2.7 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF310 PF03750.8 ERZ98573.1 - 0.045 13.9 0.3 0.11 12.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF310) Myc_N PF01056.13 ERZ98573.1 - 0.11 11.5 8.8 0.18 10.9 6.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region APH PF01636.18 ERZ98573.1 - 0.17 11.6 0.1 0.31 10.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ERZ98574.1 - 1.2e-05 24.9 0.4 2.3e-05 23.9 0.0 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ98574.1 - 0.0017 17.9 0.1 0.0053 16.3 0.0 1.9 2 0 0 2 2 2 1 F-box domain FAM194 PF14977.1 ERZ98574.1 - 0.044 12.7 0.2 0.24 10.3 0.0 1.9 2 0 0 2 2 2 0 FAM194 protein F-box-like_2 PF13013.1 ERZ98574.1 - 0.053 13.2 1.4 0.088 12.5 0.9 1.8 1 1 0 1 1 1 0 F-box-like domain HTH_Tnp_Tc3_2 PF01498.13 ERZ98575.1 - 3e-09 36.7 0.8 5.2e-09 36.0 0.6 1.4 1 0 0 1 1 1 1 Transposase Mob_synth_C PF06463.8 ERZ98576.1 - 0.11 12.1 3.3 0.22 11.2 2.3 1.4 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Pkinase_Tyr PF07714.12 ERZ98577.1 - 0.013 14.5 0.0 0.023 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase DBD_Tnp_Mut PF03108.10 ERZ98578.1 - 0.0032 17.0 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 MuDR family transposase DUF2397 PF09660.5 ERZ98578.1 - 0.089 11.3 0.2 0.28 9.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2397) MHCassoc_trimer PF08831.5 ERZ98578.1 - 0.13 12.1 1.3 0.45 10.4 0.1 2.1 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain Sarcoglycan_1 PF04790.8 ERZ98579.1 - 0.17 10.9 1.5 0.25 10.4 1.1 1.2 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Pet127 PF08634.5 ERZ98580.1 - 0.00028 20.1 0.2 0.00034 19.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet127 DND1_DSRM PF14709.1 ERZ98580.1 - 0.034 14.4 0.2 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 Ly49 PF08391.5 ERZ98580.1 - 0.16 12.0 0.9 10 6.3 0.1 2.4 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region DUF3308 PF11751.3 ERZ98581.1 - 0.048 12.9 0.0 0.048 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3308) LRR_6 PF13516.1 ERZ98583.1 - 1.6e-12 46.0 3.1 3.2e-05 23.5 0.0 4.9 5 1 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 ERZ98583.1 - 6.2e-09 35.2 0.5 7.5e-05 22.2 0.2 3.5 2 2 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ98583.1 - 3.7e-08 32.2 7.6 0.045 13.7 0.1 4.9 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_8 PF13855.1 ERZ98583.1 - 3.1e-05 23.6 2.6 0.0033 17.1 0.3 3.4 2 2 1 3 3 3 1 Leucine rich repeat LRR_7 PF13504.1 ERZ98583.1 - 0.00024 20.7 3.9 0.39 11.1 0.0 4.8 5 0 0 5 5 5 1 Leucine rich repeat DUF2097 PF09870.4 ERZ98583.1 - 0.023 14.7 0.1 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) Adeno_E4_34 PF04528.8 ERZ98583.1 - 0.031 13.8 7.3 0.089 12.3 0.9 2.3 1 1 0 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region Pkinase_Tyr PF07714.12 ERZ98584.1 - 4.1e-13 49.0 0.0 5.8e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98584.1 - 9.3e-12 44.6 0.0 1.4e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PsbU PF06514.6 ERZ98584.1 - 0.033 14.0 0.6 0.89 9.4 0.0 2.6 3 0 0 3 3 3 0 Photosystem II 12 kDa extrinsic protein (PsbU) AMP-binding PF00501.23 ERZ98585.1 - 1.1e-79 267.7 0.0 1.3e-79 267.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SCO1-SenC PF02630.9 ERZ98585.1 - 0.03 13.9 0.1 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 SCO1/SenC Cation_efflux PF01545.16 ERZ98586.1 - 2.9e-80 269.4 6.2 3.9e-80 268.9 4.3 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 ERZ98586.1 - 0.0007 18.6 6.2 0.0012 17.8 4.0 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter RP-C_C PF11800.3 ERZ98586.1 - 1.8 8.2 6.7 2.7 7.6 4.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region LRR_8 PF13855.1 ERZ98590.1 - 0.015 14.9 12.7 1.4 8.7 1.1 3.7 3 0 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 ERZ98590.1 - 1 9.6 7.1 15 6.0 0.0 4.4 3 1 0 3 3 3 0 Leucine Rich repeat DUF2770 PF10968.3 ERZ98591.1 - 0.12 12.1 0.5 0.16 11.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2770) UDPGT PF00201.13 ERZ98592.1 - 1.7e-22 79.6 0.0 2.5e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ERZ98592.1 - 2.5e-09 37.0 0.0 4e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ERZ98592.1 - 6e-08 32.2 0.0 1e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 1 F-box PF00646.28 ERZ98594.1 - 0.00025 20.6 0.3 0.00025 20.6 0.2 1.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 ERZ98594.1 - 0.00051 19.7 2.6 0.0011 18.6 1.8 1.5 1 0 0 1 1 1 1 F-box-like ELO PF01151.13 ERZ98595.1 - 0.1 11.9 0.5 0.13 11.5 0.2 1.3 1 1 0 1 1 1 0 GNS1/SUR4 family PufQ PF05398.6 ERZ98595.1 - 0.16 11.9 1.6 5.3 7.1 0.0 2.2 2 0 0 2 2 2 0 PufQ cytochrome subunit Nodulin-like PF06813.8 ERZ98596.1 - 1.7e-06 27.5 0.2 2.3e-06 27.0 0.2 1.2 1 0 0 1 1 1 1 Nodulin-like SUKH-3 PF14433.1 ERZ98598.1 - 0.087 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 SUKH-3 immunity protein MarB PF13999.1 ERZ98598.1 - 0.091 12.3 0.6 0.19 11.3 0.4 1.5 1 0 0 1 1 1 0 MarB protein DUF659 PF04937.10 ERZ98599.1 - 0.0013 18.2 0.3 0.0026 17.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) P2X_receptor PF00864.14 ERZ98600.1 - 1.6e-21 76.4 0.1 4.2e-10 38.8 0.1 3.2 2 2 2 4 4 4 2 ATP P2X receptor RhoGAP PF00620.22 ERZ98601.1 - 5.1e-14 52.1 0.0 7.1e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain RhoGAP PF00620.22 ERZ98602.1 - 8.6e-07 28.6 0.1 2.2e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain OTU PF02338.14 ERZ98603.1 - 9.8e-20 71.3 0.0 1.4e-19 70.8 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ERZ98603.1 - 2.7e-08 33.4 0.0 9.9e-05 21.7 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain XFP_C PF09363.5 ERZ98603.1 - 0.088 12.2 0.2 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 XFP C-terminal domain ACCA PF03255.9 ERZ98604.1 - 0.022 14.3 0.6 0.028 13.9 0.4 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Phasin PF05597.6 ERZ98604.1 - 0.024 14.3 0.2 0.025 14.3 0.1 1.1 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) NEMO PF11577.3 ERZ98604.1 - 0.079 12.7 0.6 0.085 12.6 0.4 1.2 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO Cyt-b5 PF00173.23 ERZ98605.1 - 1.7e-19 69.4 0.6 2.7e-19 68.7 0.0 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 ERZ98605.1 - 1.3e-09 38.4 24.7 2.4e-09 37.6 14.5 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily LIM PF00412.17 ERZ98609.1 - 0.00015 21.7 1.5 0.00023 21.1 1.0 1.4 1 0 0 1 1 1 1 LIM domain DUF788 PF05620.6 ERZ98609.1 - 7.5 6.3 7.9 7.9 6.3 5.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF788) zf-HIT PF04438.11 ERZ98610.1 - 6.3e-10 38.5 13.0 6.3e-10 38.5 9.0 1.8 2 0 0 2 2 2 1 HIT zinc finger SHQ1 PF04925.10 ERZ98610.1 - 2.5e-06 27.0 0.1 6.7e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 SHQ1 protein zf-MYND PF01753.13 ERZ98610.1 - 0.1 12.4 12.8 0.18 11.7 8.8 1.3 1 0 0 1 1 1 0 MYND finger zf-C2H2_6 PF13912.1 ERZ98610.1 - 2 8.4 6.6 1.6 8.7 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-B_box PF00643.19 ERZ98610.1 - 3.4 7.6 10.6 5.4 7.0 7.3 1.3 1 0 0 1 1 1 0 B-box zinc finger DMAP_binding PF06464.6 ERZ98611.1 - 0.009 16.5 1.3 0.011 16.2 0.9 1.1 1 0 0 1 1 1 1 DMAP1-binding Domain MobC PF05713.6 ERZ98612.1 - 0.0075 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial mobilisation protein (MobC) SSURE PF11966.3 ERZ98612.1 - 0.018 14.6 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Fibronectin-binding repeat zf-BED PF02892.10 ERZ98613.1 - 6.4e-07 29.0 2.8 1.2e-06 28.2 2.0 1.4 1 0 0 1 1 1 1 BED zinc finger zf-H2C2_5 PF13909.1 ERZ98613.1 - 0.077 13.2 3.4 0.09 13.0 0.6 2.4 1 1 1 2 2 2 0 C2H2-type zinc-finger domain SR-25 PF10500.4 ERZ98614.1 - 3.3 7.1 11.6 4.4 6.7 8.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sel1 PF08238.7 ERZ98615.1 - 5.2e-06 26.9 0.4 1.2e-05 25.8 0.3 1.5 1 0 0 1 1 1 1 Sel1 repeat Arch_ATPase PF01637.13 ERZ98615.1 - 0.019 14.6 1.6 0.019 14.6 1.1 1.8 2 0 0 2 2 2 0 Archaeal ATPase DUF3452 PF11934.3 ERZ98617.1 - 0.0027 17.0 0.7 0.0069 15.7 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) DUF3452 PF11934.3 ERZ98618.1 - 0.025 13.8 0.8 0.061 12.6 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) CTD_bind PF04818.8 ERZ98622.1 - 0.0095 16.1 1.1 5 7.4 0.1 2.6 2 0 0 2 2 2 2 RNA polymerase II-binding domain. Bromodomain PF00439.20 ERZ98622.1 - 0.93 9.4 3.9 13 5.8 0.0 2.9 2 1 1 3 3 3 0 Bromodomain LRR_8 PF13855.1 ERZ98623.1 - 1.5e-18 66.2 9.7 7.3e-07 28.8 0.2 2.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ERZ98623.1 - 1.7e-14 52.9 5.6 5.9e-07 28.9 0.2 2.5 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ98623.1 - 1.3e-10 40.1 6.8 0.00045 20.0 0.0 3.8 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.28 ERZ98623.1 - 1.7e-10 39.4 2.6 0.073 13.1 0.0 3.3 3 0 0 3 3 3 3 Leucine Rich Repeat LRR_7 PF13504.1 ERZ98623.1 - 4.7e-09 34.9 1.2 0.052 13.7 0.0 3.4 3 1 0 3 3 3 3 Leucine rich repeat Adeno_E4_34 PF04528.8 ERZ98623.1 - 1.2 8.6 5.8 10 5.6 0.1 2.0 1 1 1 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region LRR_2 PF07723.8 ERZ98623.1 - 2.8 8.5 6.1 12 6.5 0.8 3.1 3 0 0 3 3 3 0 Leucine Rich Repeat Pyr_excise PF03013.9 ERZ98625.1 - 0.029 14.1 0.3 0.054 13.2 0.2 1.6 1 1 0 1 1 1 0 Pyrimidine dimer DNA glycosylase NinF PF05810.7 ERZ98626.1 - 0.021 14.5 0.9 0.048 13.4 0.6 1.6 1 0 0 1 1 1 0 NinF protein zf-B_box PF00643.19 ERZ98626.1 - 0.36 10.7 5.3 0.62 10.0 3.7 1.3 1 0 0 1 1 1 0 B-box zinc finger HSP70 PF00012.15 ERZ98628.1 - 0.004 15.1 0.0 0.0047 14.9 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.15 ERZ98629.1 - 0.027 13.7 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family zf-TFIIB PF13453.1 ERZ98629.1 - 0.088 12.0 0.1 0.21 10.8 0.1 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Phage_lysozyme PF00959.14 ERZ98630.1 - 9.3e-17 61.3 0.0 1.1e-16 61.1 0.0 1.0 1 0 0 1 1 1 1 Phage lysozyme HSP70 PF00012.15 ERZ98631.1 - 0.00034 18.6 0.1 0.53 8.1 0.0 2.5 2 1 0 2 2 2 2 Hsp70 protein BcrAD_BadFG PF01869.15 ERZ98631.1 - 0.036 13.3 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Peptidase_M16 PF00675.15 ERZ98632.1 - 8.1e-40 136.0 0.7 2.2e-38 131.3 0.1 3.3 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ERZ98632.1 - 1.1e-37 129.5 2.4 4.1e-22 78.7 0.0 3.7 4 0 0 4 4 4 2 Peptidase M16 inactive domain DUF4629 PF15442.1 ERZ98632.1 - 0.027 14.6 4.0 0.057 13.5 2.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) Exo_endo_phos PF03372.18 ERZ98633.1 - 0.00067 19.6 0.1 0.00082 19.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PucR PF07905.6 ERZ98633.1 - 0.04 13.5 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family GP41 PF00517.12 ERZ98634.1 - 0.018 14.5 1.9 0.02 14.4 1.3 1.2 1 0 0 1 1 1 0 Retroviral envelope protein SUKH-3 PF14433.1 ERZ98634.1 - 0.12 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 SUKH-3 immunity protein Fb_signal PF08341.6 ERZ98634.1 - 0.32 11.0 2.6 0.5 10.4 1.7 1.5 1 1 0 1 1 1 0 Fibronectin-binding protein signal sequence DUF1712 PF08217.6 ERZ98637.1 - 6.5e-41 140.2 8.8 3.9e-33 114.5 0.4 3.1 2 1 1 3 3 3 3 Fungal domain of unknown function (DUF1712) Flp_N PF03930.9 ERZ98637.1 - 0.041 13.6 0.9 8.7 6.1 0.1 2.5 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus DUF3519 PF12033.3 ERZ98637.1 - 0.16 12.1 3.3 0.19 11.9 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3519) CybS PF05328.7 ERZ98638.1 - 1.8e-42 144.1 0.0 2.2e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 CybS Aldedh PF00171.17 ERZ98639.1 - 1.7e-132 442.0 0.0 1.9e-132 441.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 ERZ98639.1 - 0.041 12.5 0.0 0.073 11.7 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) CLP_protease PF00574.18 ERZ98640.1 - 1.4e-73 246.4 0.1 1.9e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 Clp protease NUMOD1 PF07453.8 ERZ98641.1 - 0.072 12.9 8.0 0.99 9.3 0.3 2.7 2 0 0 2 2 2 0 NUMOD1 domain HTH_17 PF12728.2 ERZ98641.1 - 0.15 12.3 0.4 2 8.7 0.0 2.7 2 1 1 3 3 3 0 Helix-turn-helix domain PAP2_C PF14360.1 ERZ98642.1 - 0.00049 20.3 0.2 0.00049 20.3 0.2 2.9 3 0 0 3 3 3 1 PAP2 superfamily C-terminal HEAT_2 PF13646.1 ERZ98643.1 - 6.8e-10 39.1 0.0 1e-06 28.8 0.0 3.2 1 1 2 3 3 3 1 HEAT repeats HEAT PF02985.17 ERZ98643.1 - 0.00027 20.7 1.0 21 5.5 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.1 ERZ98643.1 - 0.018 15.5 0.3 6.7 7.3 0.0 3.5 4 0 0 4 4 4 0 HEAT-like repeat Cohesin_HEAT PF12765.2 ERZ98643.1 - 0.019 14.9 0.1 13 5.8 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.3 ERZ98643.1 - 0.052 12.8 0.1 3.9 6.7 0.0 2.4 2 0 0 2 2 2 0 CLASP N terminal DivIVA PF05103.8 ERZ98644.1 - 0.081 12.9 2.5 0.13 12.3 1.7 1.3 1 0 0 1 1 1 0 DivIVA protein DUF972 PF06156.8 ERZ98644.1 - 0.32 11.3 6.3 1.1 9.6 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Pkinase PF00069.20 ERZ98646.1 - 9.7e-49 165.8 0.4 1.4e-47 162.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98646.1 - 4e-48 163.7 0.0 5.3e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ98646.1 - 0.00035 19.9 0.1 0.00087 18.6 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ98646.1 - 0.00056 18.9 0.0 0.36 9.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ERZ98646.1 - 0.023 14.4 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ERZ98646.1 - 0.024 13.7 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Presenilin PF01080.12 ERZ98646.1 - 0.23 10.2 0.9 0.34 9.6 0.6 1.1 1 0 0 1 1 1 0 Presenilin TPR_2 PF07719.12 ERZ98647.1 - 2.3e-05 23.9 1.5 0.002 17.8 0.6 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ98647.1 - 0.00015 21.3 3.4 0.027 14.1 0.1 3.6 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.1 ERZ98647.1 - 0.00017 21.8 0.1 0.0015 18.8 0.0 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ98647.1 - 0.00092 18.7 6.8 0.016 14.8 1.6 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ERZ98647.1 - 0.0021 17.9 1.1 0.0021 17.9 0.8 2.5 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 ERZ98647.1 - 0.0086 16.1 11.3 0.08 13.0 0.2 3.9 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ERZ98647.1 - 0.017 15.7 0.0 1.4 9.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ98647.1 - 0.037 13.8 7.7 0.019 14.7 2.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Myosin_tail_1 PF01576.14 ERZ98648.1 - 5.8e-06 24.3 9.2 5.8e-06 24.3 6.4 2.0 1 1 1 2 2 2 2 Myosin tail DUF2353 PF09789.4 ERZ98648.1 - 1.1e-05 24.8 14.1 1.4e-05 24.4 9.8 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) GOLGA2L5 PF15070.1 ERZ98648.1 - 0.00085 17.9 7.2 0.001 17.6 5.0 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 bZIP_2 PF07716.10 ERZ98648.1 - 0.00089 19.0 10.0 0.084 12.7 1.5 2.6 2 0 0 2 2 2 2 Basic region leucine zipper OrfB_IS605 PF01385.14 ERZ98648.1 - 0.0018 17.6 3.1 0.0086 15.4 0.1 2.0 1 1 1 2 2 2 1 Probable transposase DivIC PF04977.10 ERZ98648.1 - 0.0019 17.6 10.1 0.017 14.5 0.5 2.5 2 0 0 2 2 2 1 Septum formation initiator Filament PF00038.16 ERZ98648.1 - 0.011 15.1 15.0 0.12 11.8 3.2 2.1 1 1 1 2 2 2 0 Intermediate filament protein Bacillus_HBL PF05791.6 ERZ98648.1 - 0.016 14.5 5.9 0.022 14.1 4.1 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Prefoldin PF02996.12 ERZ98648.1 - 0.018 14.7 10.4 0.12 12.0 0.4 2.4 2 0 0 2 2 2 0 Prefoldin subunit bZIP_1 PF00170.16 ERZ98648.1 - 0.024 14.5 12.7 0.073 13.0 0.5 3.0 2 2 1 3 3 3 0 bZIP transcription factor Reo_sigmaC PF04582.7 ERZ98648.1 - 0.027 13.6 1.5 0.03 13.5 1.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Transposase_22 PF02994.9 ERZ98648.1 - 0.027 12.9 10.2 0.031 12.7 7.1 1.1 1 0 0 1 1 1 0 L1 transposable element DUF4618 PF15397.1 ERZ98648.1 - 0.028 13.7 12.0 0.11 11.7 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) YlqD PF11068.3 ERZ98648.1 - 0.034 14.2 12.0 0.043 13.8 7.8 1.5 1 1 0 1 1 1 0 YlqD protein BMFP PF04380.8 ERZ98648.1 - 0.037 14.1 4.2 1.1 9.5 0.5 2.5 2 0 0 2 2 2 0 Membrane fusogenic activity Exonuc_VII_L PF02601.10 ERZ98648.1 - 0.038 13.1 5.4 0.048 12.8 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.4 ERZ98648.1 - 0.045 12.7 11.3 0.054 12.4 7.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Matrilin_ccoil PF10393.4 ERZ98648.1 - 0.058 12.7 1.4 0.058 12.7 0.9 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Bac_transf PF02397.11 ERZ98648.1 - 0.095 11.8 0.3 0.12 11.4 0.2 1.2 1 0 0 1 1 1 0 Bacterial sugar transferase WD40_alt PF14077.1 ERZ98648.1 - 0.12 12.0 1.0 9.3 5.9 0.1 2.6 2 0 0 2 2 2 0 Alternative WD40 repeat motif ATG16 PF08614.6 ERZ98648.1 - 0.12 12.2 16.8 0.38 10.5 11.6 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4315 PF14193.1 ERZ98648.1 - 0.19 11.6 13.7 0.067 13.1 3.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4315) ADIP PF11559.3 ERZ98648.1 - 0.21 11.5 16.9 0.059 13.2 3.3 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mnd1 PF03962.10 ERZ98648.1 - 0.22 11.1 13.1 0.34 10.5 9.0 1.3 1 1 0 1 1 1 0 Mnd1 family TBPIP PF07106.8 ERZ98648.1 - 0.23 10.9 15.5 6.1 6.3 10.7 2.1 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4140 PF13600.1 ERZ98648.1 - 0.26 11.7 10.3 2.2 8.7 2.7 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2968 PF11180.3 ERZ98648.1 - 0.34 10.2 13.1 0.66 9.3 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) PRD PF00874.15 ERZ98648.1 - 0.35 11.0 3.3 0.35 10.9 0.6 2.0 1 1 0 2 2 2 0 PRD domain ORF6C PF10552.4 ERZ98648.1 - 0.41 10.3 8.1 0.16 11.7 1.2 2.3 1 1 1 2 2 2 0 ORF6C domain DUF730 PF05325.6 ERZ98648.1 - 0.58 9.9 3.6 0.17 11.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF730) CENP-F_leu_zip PF10473.4 ERZ98648.1 - 0.62 9.9 20.3 1.1 9.1 14.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.3 ERZ98648.1 - 0.66 9.8 16.6 0.26 11.1 3.1 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.7 ERZ98648.1 - 0.68 9.7 11.5 3.5 7.4 3.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF904 PF06005.7 ERZ98648.1 - 0.69 10.2 18.5 2.9 8.2 2.9 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF904) FlaC_arch PF05377.6 ERZ98648.1 - 0.73 9.7 6.1 1.5 8.7 0.5 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3338 PF11819.3 ERZ98648.1 - 0.76 9.2 9.8 3.7 6.9 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3338) Kinetocho_Slk19 PF12709.2 ERZ98648.1 - 0.91 9.6 12.3 2.1 8.4 1.5 2.8 1 1 1 3 3 3 0 Central kinetochore-associated Uds1 PF15456.1 ERZ98648.1 - 1.1 9.2 11.8 3.3 7.7 7.8 1.9 1 1 1 2 2 2 0 Up-regulated During Septation Tup_N PF08581.5 ERZ98648.1 - 1.1 9.5 12.3 0.23 11.6 4.5 2.4 1 1 1 2 2 2 0 Tup N-terminal Spc7 PF08317.6 ERZ98648.1 - 1.3 7.6 15.5 1.8 7.1 10.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.3 ERZ98648.1 - 1.8 7.7 13.1 9.7 5.3 7.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.17 ERZ98648.1 - 1.8 8.5 14.5 9 6.3 3.7 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3573 PF12097.3 ERZ98648.1 - 2.2 6.7 4.9 2.9 6.4 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) APG6 PF04111.7 ERZ98648.1 - 2.6 6.9 16.4 4.4 6.2 11.4 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 DUF3287 PF11690.3 ERZ98648.1 - 2.9 7.9 6.9 3.2 7.8 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) IncA PF04156.9 ERZ98648.1 - 4.1 6.9 18.8 14 5.2 13.1 1.8 1 1 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 ERZ98648.1 - 4.1 7.3 11.8 4.7 7.1 7.9 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein Rho_Binding PF08912.6 ERZ98648.1 - 4.3 7.7 12.7 9.3 6.6 1.6 2.7 2 1 0 2 2 2 0 Rho Binding Cep57_CLD_2 PF14197.1 ERZ98648.1 - 5.9 6.9 17.3 2.6 8.0 1.4 3.2 1 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF948 PF06103.6 ERZ98648.1 - 6 6.8 6.6 5.8 6.8 0.8 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF334 PF03904.8 ERZ98648.1 - 6.8 5.9 10.6 1.8 7.8 1.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF334) TSC22 PF01166.13 ERZ98648.1 - 7.2 6.6 10.3 3 7.8 0.5 3.2 1 1 1 3 3 3 0 TSC-22/dip/bun family DUF342 PF03961.8 ERZ98648.1 - 9.3 4.5 10.7 14 3.9 6.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Pox_A32 PF04665.7 ERZ98649.1 - 5e-12 45.6 0.1 7.3e-09 35.2 0.0 2.3 2 0 0 2 2 2 2 Poxvirus A32 protein Zot PF05707.7 ERZ98649.1 - 0.00044 19.7 0.0 0.031 13.7 0.0 2.3 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_10 PF12846.2 ERZ98649.1 - 0.00066 19.1 0.0 0.34 10.3 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain AAA_22 PF13401.1 ERZ98649.1 - 0.011 15.8 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ERZ98649.1 - 0.015 14.9 0.1 0.056 13.1 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.1 ERZ98649.1 - 0.035 14.9 0.0 0.056 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ERZ98649.1 - 0.054 12.9 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ERZ98649.1 - 0.1 12.1 0.1 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 ERZ98649.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF4389 PF14333.1 ERZ98650.1 - 0.17 11.6 4.5 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) MARVEL PF01284.18 ERZ98650.1 - 0.39 10.5 6.6 13 5.5 4.5 2.5 1 1 0 1 1 1 0 Membrane-associating domain DUF3533 PF12051.3 ERZ98650.1 - 3.2 6.4 9.6 0.31 9.7 3.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3533) DUF3876 PF12992.2 ERZ98651.1 - 0.023 14.6 0.2 0.029 14.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3876) Dimer_Tnp_hAT PF05699.9 ERZ98652.1 - 5.3e-17 61.2 0.0 5.6e-17 61.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2457 PF10446.4 ERZ98656.1 - 0.05 12.3 4.8 0.084 11.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Vps8 PF12816.2 ERZ98657.1 - 1.6e-63 213.5 2.3 1.8e-61 206.8 0.0 3.7 3 1 0 3 3 3 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 ERZ98657.1 - 1.2e-06 28.1 2.1 0.015 14.9 0.1 3.6 4 0 0 4 4 4 2 Region in Clathrin and VPS 4HB_MCP_1 PF12729.2 ERZ98657.1 - 0.046 13.0 4.9 0.67 9.2 1.1 3.2 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction VMA21 PF09446.5 ERZ98658.1 - 1e-10 41.3 4.1 1.4e-10 40.9 2.8 1.2 1 0 0 1 1 1 1 VMA21-like domain UPF0104 PF03706.8 ERZ98658.1 - 0.054 12.7 0.0 0.059 12.6 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) Peptidase_A22B PF04258.8 ERZ98659.1 - 3.3e-75 253.3 14.9 4.3e-75 252.9 10.4 1.1 1 0 0 1 1 1 1 Signal peptide peptidase DUF1119 PF06550.6 ERZ98659.1 - 0.0019 17.3 18.2 0.003 16.7 11.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1119) GMC_oxred_C PF05199.8 ERZ98660.1 - 2.9e-14 53.5 0.0 2.7e-13 50.4 0.0 2.5 2 0 0 2 2 2 1 GMC oxidoreductase Abhydrolase_5 PF12695.2 ERZ98660.1 - 2.3e-08 33.9 0.0 3.2e-07 30.1 0.0 2.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ERZ98660.1 - 1.6e-07 31.4 0.0 1.3e-06 28.4 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family GMC_oxred_N PF00732.14 ERZ98660.1 - 2.9e-06 26.6 0.0 2.1e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 ERZ98660.1 - 2.5e-05 23.2 0.2 3.9e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 ERZ98660.1 - 0.00012 21.2 0.2 0.0002 20.6 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 ERZ98660.1 - 0.00062 18.7 0.1 0.0012 17.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ERZ98660.1 - 0.001 19.0 0.5 0.0032 17.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ERZ98660.1 - 0.0015 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ERZ98660.1 - 0.0031 16.0 0.1 0.0054 15.2 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 ERZ98660.1 - 0.0031 16.6 0.4 0.0077 15.3 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 ERZ98660.1 - 0.0068 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ERZ98660.1 - 0.01 14.7 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A GDI PF00996.13 ERZ98660.1 - 0.046 12.0 0.0 0.082 11.2 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Abhydrolase_2 PF02230.11 ERZ98660.1 - 0.06 12.7 0.0 0.21 10.9 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 ERZ98660.1 - 0.16 11.5 1.4 2.2 7.7 0.1 3.2 3 1 0 3 3 3 0 alpha/beta hydrolase fold Tetraspannin PF00335.15 ERZ98661.1 - 0.11 11.8 18.6 0.94 8.7 12.4 2.2 1 1 1 2 2 2 0 Tetraspanin family Consortin_C PF15281.1 ERZ98661.1 - 0.27 10.7 1.0 11 5.6 0.3 2.5 2 0 0 2 2 2 0 Consortin C-terminus MgtE PF01769.11 ERZ98661.1 - 1.2 9.3 8.8 10 6.3 0.1 2.3 1 1 1 2 2 2 0 Divalent cation transporter Usp PF00582.21 ERZ98662.1 - 2.2e-15 57.0 0.0 5.4e-15 55.8 0.0 1.6 1 1 0 1 1 1 1 Universal stress protein family Peptidase_S9 PF00326.16 ERZ98663.1 - 2.3e-37 128.3 0.0 3.3e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 ERZ98663.1 - 4.4e-10 39.4 0.0 8.8e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ERZ98663.1 - 7.5e-06 25.9 0.0 3.2e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ98663.1 - 3.9e-05 23.3 0.0 0.00013 21.6 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ERZ98663.1 - 0.0011 18.4 0.0 0.64 9.4 0.0 2.5 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase DLH PF01738.13 ERZ98663.1 - 0.0083 15.4 0.0 0.2 10.9 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.6 ERZ98663.1 - 0.056 13.1 0.1 0.22 11.1 0.0 2.0 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase_phd PF10503.4 ERZ98663.1 - 0.16 11.1 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Esterase PF00756.15 ERZ98663.1 - 0.19 11.1 0.0 0.44 9.9 0.0 1.6 2 0 0 2 2 2 0 Putative esterase ParA PF10609.4 ERZ98664.1 - 5.3e-36 122.3 1.2 1.6e-35 120.8 0.5 2.0 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 ERZ98664.1 - 1.2e-18 67.2 0.1 2.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ERZ98664.1 - 1.3e-07 31.0 0.0 2.3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 ERZ98664.1 - 1.3e-07 31.6 0.0 1.4e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain Fer4_NifH PF00142.13 ERZ98664.1 - 1e-05 24.8 0.0 0.0011 18.2 0.0 2.4 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.10 ERZ98664.1 - 3.6e-05 22.9 1.7 0.0029 16.7 0.3 2.9 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_19 PF13245.1 ERZ98664.1 - 0.0065 16.1 0.4 2.7 7.8 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 ERZ98664.1 - 0.009 15.4 0.9 0.022 14.1 0.6 1.7 1 1 0 1 1 1 1 AAA domain VirC1 PF07015.6 ERZ98664.1 - 0.015 14.3 0.0 0.035 13.1 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein PhnA_Zn_Ribbon PF08274.7 ERZ98664.1 - 0.084 12.6 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 PhnA Zinc-Ribbon SRP54 PF00448.17 ERZ98664.1 - 0.12 11.7 0.3 0.41 10.0 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain E1_DerP2_DerF2 PF02221.10 ERZ98665.1 - 0.00018 21.7 0.3 0.00083 19.6 0.2 1.9 1 1 0 1 1 1 1 ML domain HSP20 PF00011.16 ERZ98668.1 - 0.04 13.7 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Hsp20/alpha crystallin family MannoseP_isomer PF01050.13 ERZ98668.1 - 0.07 12.7 0.0 0.078 12.5 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Hemerythrin PF01814.18 ERZ98669.1 - 0.0055 16.8 1.0 0.3 11.2 0.1 2.3 1 1 1 2 2 2 1 Hemerythrin HHE cation binding domain HTH_27 PF13463.1 ERZ98669.1 - 0.07 13.4 0.3 0.17 12.2 0.1 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain DUF484 PF04340.7 ERZ98669.1 - 0.077 12.4 0.1 0.089 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF484 TBCA PF02970.11 ERZ98669.1 - 0.41 10.7 5.6 0.38 10.8 2.7 1.9 1 1 1 2 2 2 0 Tubulin binding cofactor A DUF2458 PF10454.4 ERZ98669.1 - 1.7 8.5 8.8 8 6.3 6.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) DUF2951 PF11166.3 ERZ98669.1 - 9.7 6.1 8.8 5 7.0 0.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2951) DUF342 PF03961.8 ERZ98669.1 - 9.9 4.4 9.3 14 3.9 6.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Pkinase_Tyr PF07714.12 ERZ98670.1 - 0.00087 18.4 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98673.1 - 1.4e-77 260.3 0.2 1.8e-77 260.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98673.1 - 7.8e-41 139.8 0.0 1.1e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98673.1 - 1.1e-06 27.8 0.0 2.5e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 ERZ98673.1 - 6.7e-05 22.3 0.0 6.7e-05 22.3 0.0 1.8 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ERZ98673.1 - 0.0021 17.1 0.1 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ98673.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PACT_coil_coil PF10495.4 ERZ98673.1 - 0.059 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein RPAP3_C PF13877.1 ERZ98673.1 - 0.15 12.0 0.9 9.9 6.2 0.1 2.7 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 Cpn60_TCP1 PF00118.19 ERZ98674.1 - 7.3e-151 503.0 4.6 8.3e-151 502.8 3.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YbjQ_1 PF01906.12 ERZ98674.1 - 0.076 13.4 0.2 0.55 10.6 0.0 2.3 2 0 0 2 2 2 0 Putative heavy-metal-binding GTP_EFTU PF00009.22 ERZ98675.1 - 1.3e-34 119.2 0.0 1.1e-33 116.2 0.0 2.3 2 1 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ERZ98675.1 - 1.6e-25 89.1 0.9 3.5e-25 88.0 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ERZ98675.1 - 2.3e-09 37.2 0.8 5.9e-09 35.9 0.6 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ERZ98675.1 - 0.075 12.9 0.0 0.23 11.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Mito_carr PF00153.22 ERZ98676.1 - 1.1e-37 127.5 9.7 3.3e-18 65.1 0.1 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein Fungal_trans PF04082.13 ERZ98677.1 - 1.1e-13 50.6 0.3 2.5e-13 49.5 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ERZ98678.1 - 5.5e-09 35.7 14.8 9.6e-09 35.0 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC74_C PF14917.1 ERZ98678.1 - 0.097 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Coiled coil protein 74, C terminal Arm PF00514.18 ERZ98679.1 - 2.9e-21 74.4 21.1 8.4e-06 25.4 0.1 9.2 8 1 0 8 8 8 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ERZ98679.1 - 3.5e-10 40.0 0.2 0.018 15.3 0.0 4.4 1 1 4 5 5 5 5 HEAT repeats HEAT_EZ PF13513.1 ERZ98679.1 - 4.1e-10 39.8 1.3 0.037 14.5 0.1 5.3 3 1 1 4 4 4 4 HEAT-like repeat YadA_stalk PF05662.9 ERZ98679.1 - 0.098 12.4 3.2 24 4.9 0.0 3.5 3 0 0 3 3 3 0 Coiled stalk of trimeric autotransporter adhesin HEAT PF02985.17 ERZ98679.1 - 2.4 8.4 8.6 12 6.2 0.0 4.4 6 0 0 6 6 6 0 HEAT repeat DUF2423 PF10338.4 ERZ98680.1 - 1.1e-11 44.5 1.6 1.6e-11 44.0 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Laps PF10169.4 ERZ98680.1 - 2 8.6 4.9 4.7 7.4 3.4 1.7 1 1 0 1 1 1 0 Learning-associated protein Aconitase PF00330.15 ERZ98681.1 - 4.9e-77 259.3 0.0 2.9e-44 151.3 0.0 3.1 2 1 1 3 3 3 3 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 ERZ98681.1 - 1.5e-22 80.1 0.0 3.3e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 ERZ98681.1 - 0.037 12.5 0.0 0.06 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) HbrB PF08539.6 ERZ98682.1 - 4.5e-28 98.0 0.6 1.3e-18 67.3 0.2 3.5 2 1 1 3 3 3 2 HbrB-like NPR3 PF03666.8 ERZ98683.1 - 4e-95 319.0 8.7 2.4e-47 161.5 0.1 2.3 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 DUF4065 PF13274.1 ERZ98683.1 - 0.3 11.7 3.2 0.44 11.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) Kelch_4 PF13418.1 ERZ98684.1 - 7.3e-30 102.4 0.5 1.1e-09 37.8 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ98684.1 - 2.9e-29 100.5 0.6 1.9e-08 34.2 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ98684.1 - 8.7e-27 92.1 3.5 1.3e-06 28.3 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ERZ98684.1 - 2.5e-26 91.1 1.8 6.5e-07 29.1 0.0 5.1 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ERZ98684.1 - 1.6e-22 78.3 1.1 4.4e-08 32.5 0.0 4.7 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.20 ERZ98684.1 - 4.8e-18 64.4 10.4 7.1e-05 22.2 0.2 5.0 5 0 0 5 5 5 4 Kelch motif BTB PF00651.26 ERZ98684.1 - 4.3e-12 45.9 0.0 1.7e-11 44.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ98684.1 - 1.4e-05 24.8 0.0 3.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Rax2 PF12768.2 ERZ98684.1 - 0.00012 21.3 0.2 0.047 12.9 0.0 2.4 1 1 1 2 2 2 2 Cortical protein marker for cell polarity HA2 PF04408.18 ERZ98685.1 - 6.8e-22 77.4 0.1 6.8e-22 77.4 0.0 2.5 3 0 0 3 3 3 1 Helicase associated domain (HA2) dsrm PF00035.20 ERZ98685.1 - 1.2e-21 77.0 0.0 7.6e-09 36.0 0.0 4.1 3 0 0 3 3 3 3 Double-stranded RNA binding motif Helicase_C PF00271.26 ERZ98685.1 - 5.6e-13 48.5 0.1 1.6e-12 47.0 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 ERZ98685.1 - 5.8e-13 48.6 0.0 1.9e-12 46.9 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 ERZ98685.1 - 2.8e-07 30.1 0.0 7.4e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.1 ERZ98685.1 - 0.026 14.2 0.1 0.11 12.3 0.1 2.1 1 1 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 ERZ98685.1 - 0.058 13.5 0.3 0.36 10.9 0.2 2.4 1 1 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.26 ERZ98686.1 - 5.4e-39 132.0 10.4 5.8e-08 32.6 0.1 6.4 5 1 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ98686.1 - 2.2e-29 101.3 26.7 6e-10 39.0 0.0 6.4 3 2 3 6 6 6 5 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ERZ98686.1 - 2.1e-05 24.5 21.6 0.021 14.9 0.3 5.5 3 2 3 6 6 6 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 ERZ98686.1 - 6.8e-05 22.5 2.7 0.6 9.9 0.0 4.8 5 1 0 5 5 5 2 Rap1 Myb domain Myb_DNA-bind_5 PF13873.1 ERZ98686.1 - 0.00019 21.2 24.0 0.041 13.7 0.1 7.2 3 2 4 8 8 8 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ERZ98686.1 - 8.9 6.5 13.9 4.4 7.5 0.2 4.9 4 1 0 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Mis14 PF08641.7 ERZ98687.1 - 7.4e-10 39.0 3.8 1.1e-09 38.4 1.4 2.0 1 1 1 2 2 2 1 Kinetochore protein Mis14 like Ribosomal_L21e PF01157.13 ERZ98688.1 - 0.14 11.9 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L21e F-box-like PF12937.2 ERZ98689.1 - 0.018 14.7 3.1 0.018 14.7 2.1 2.2 2 0 0 2 2 2 0 F-box-like LRR_8 PF13855.1 ERZ98689.1 - 0.05 13.3 3.5 0.42 10.4 0.2 3.3 2 1 1 3 3 3 0 Leucine rich repeat LRR_4 PF12799.2 ERZ98689.1 - 0.093 12.3 4.7 0.23 11.1 0.5 3.2 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ERZ98689.1 - 6.9 7.0 6.6 27 5.2 0.2 4.2 3 1 0 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.2 ERZ98691.1 - 0.013 15.0 12.2 0.079 12.6 0.4 4.1 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Prp18 PF02840.10 ERZ98691.1 - 0.088 12.6 0.1 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Prp18 domain Erv26 PF04148.8 ERZ98693.1 - 0.016 14.5 0.7 0.016 14.5 0.5 2.4 2 1 0 3 3 3 0 Transmembrane adaptor Erv26 DUF3753 PF12575.3 ERZ98693.1 - 0.08 12.7 0.9 6.5 6.6 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) YfhO PF09586.5 ERZ98693.1 - 0.22 9.5 5.6 0.3 9.0 3.9 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF308 PF03729.8 ERZ98693.1 - 0.48 10.4 6.8 2.2 8.3 3.1 2.7 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF3099 PF11298.3 ERZ98693.1 - 4.9 6.9 6.6 11 5.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) F-box-like PF12937.2 ERZ98695.1 - 1.3e-07 31.1 3.8 4.3e-07 29.5 2.6 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ERZ98695.1 - 0.13 11.8 14.8 5.6 6.7 0.3 5.2 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) F-box PF00646.28 ERZ98695.1 - 1 9.0 5.5 0.41 10.3 1.1 2.5 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.2 ERZ98696.1 - 5.4e-07 29.2 2.6 5.8e-07 29.1 1.0 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ98696.1 - 0.025 14.2 2.3 0.025 14.2 1.6 2.7 2 2 0 2 2 2 0 F-box domain F-box-like PF12937.2 ERZ98697.1 - 0.00011 21.7 2.9 0.0003 20.4 1.4 2.2 2 0 0 2 2 2 1 F-box-like DUF870 PF05912.6 ERZ98697.1 - 0.22 11.3 2.3 0.24 11.2 0.3 2.1 2 0 0 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF870) TPR_2 PF07719.12 ERZ98698.1 - 1.2e-28 96.6 18.9 0.00015 21.4 0.1 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ98698.1 - 1.1e-27 95.3 31.4 1.7e-10 40.4 0.5 6.6 6 1 1 7 7 7 4 TPR repeat TPR_1 PF00515.23 ERZ98698.1 - 2.9e-20 70.9 40.7 0.0002 20.8 0.7 9.8 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ98698.1 - 1.8e-18 65.1 24.2 0.011 15.9 0.1 9.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ98698.1 - 2.4e-15 56.7 0.0 1e-05 26.0 0.1 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ98698.1 - 3.2e-13 49.8 1.6 0.0051 17.1 0.0 5.3 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ98698.1 - 3.8e-12 45.0 35.8 0.035 13.8 0.5 8.4 6 2 3 9 9 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ98698.1 - 4.8e-11 42.2 0.0 0.4 11.4 0.0 7.0 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ98698.1 - 1.5e-10 40.8 9.1 0.0047 16.8 0.0 5.0 4 1 2 6 6 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ERZ98698.1 - 7.6e-10 38.7 22.4 6.5e-05 22.9 1.6 4.8 2 1 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ERZ98698.1 - 2.8e-07 30.5 1.7 0.014 15.8 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ERZ98698.1 - 4.3e-06 26.4 14.7 0.022 14.6 0.4 6.3 6 0 0 6 6 6 3 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 ERZ98698.1 - 8.1e-06 25.2 4.4 0.32 10.8 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ98698.1 - 2e-05 24.3 0.0 0.86 9.5 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat NARP1 PF12569.3 ERZ98698.1 - 0.0031 16.3 0.1 0.0031 16.3 0.1 3.1 3 1 1 4 4 4 1 NMDA receptor-regulated protein 1 SHNi-TPR PF10516.4 ERZ98698.1 - 0.0058 15.8 0.1 0.41 9.9 0.0 3.4 3 0 0 3 3 3 1 SHNi-TPR zf-C3HC4_3 PF13920.1 ERZ98698.1 - 0.02 14.5 3.6 0.05 13.2 2.5 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ERZ98698.1 - 0.03 14.0 7.7 0.025 14.3 3.0 2.6 2 0 0 2 2 2 0 zinc-RING finger domain Med27 PF11571.3 ERZ98698.1 - 0.03 14.4 1.7 0.18 11.9 0.5 3.0 2 1 0 2 2 1 0 Mediator complex subunit 27 zf-RING_UBOX PF13445.1 ERZ98698.1 - 0.1 12.3 4.9 0.47 10.2 3.4 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.1 ERZ98698.1 - 0.95 9.3 3.9 2.7 7.9 2.7 1.8 1 0 0 1 1 1 0 Ring finger domain Sel1 PF08238.7 ERZ98700.1 - 5.4e-50 166.7 18.7 3.5e-12 46.5 0.6 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ERZ98700.1 - 3.8e-08 33.2 11.8 0.14 12.6 0.2 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ98700.1 - 0.0027 17.3 19.6 0.17 11.5 6.8 4.1 2 1 1 4 4 4 2 TPR repeat TPR_12 PF13424.1 ERZ98700.1 - 0.022 14.6 16.2 0.55 10.2 5.3 4.4 1 1 3 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ERZ98700.1 - 0.027 14.3 11.7 0.51 10.2 0.5 4.0 1 1 3 4 4 4 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ERZ98700.1 - 0.049 14.1 10.2 11 7.1 0.2 5.7 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TRI5 PF06330.6 ERZ98700.1 - 0.082 11.5 1.4 3.1 6.3 0.1 2.2 1 1 1 2 2 2 0 Trichodiene synthase (TRI5) TPR_7 PF13176.1 ERZ98700.1 - 0.18 11.6 7.9 13 5.8 0.1 4.8 5 1 0 5 5 5 0 Tetratricopeptide repeat Destabilase PF05497.7 ERZ98700.1 - 0.2 11.7 2.8 0.36 10.9 1.4 1.7 1 1 1 2 2 2 0 Destabilase TPR_16 PF13432.1 ERZ98700.1 - 0.53 11.0 5.9 2.3 9.0 0.3 3.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ98700.1 - 2.8 8.3 13.5 4.5 7.7 1.3 4.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ98700.1 - 8.6 6.5 27.6 24 5.1 0.1 7.2 9 0 0 9 9 9 0 Tetratricopeptide repeat Pkinase PF00069.20 ERZ98701.1 - 1.9e-29 102.6 0.0 2e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98701.1 - 3.8e-28 98.2 0.0 4.3e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ98701.1 - 0.0023 17.3 0.1 0.0029 16.9 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ERZ98701.1 - 0.0045 16.0 0.0 0.0055 15.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ98701.1 - 0.0054 15.7 0.0 0.0058 15.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ERZ98701.1 - 0.011 15.4 0.1 0.015 15.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF659 PF04937.10 ERZ98702.1 - 1.9e-06 27.4 0.2 5e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) zf-BED PF02892.10 ERZ98702.1 - 9.7e-06 25.2 3.9 2.1e-05 24.1 2.7 1.6 1 0 0 1 1 1 1 BED zinc finger OCIA PF07051.6 ERZ98703.1 - 0.0097 15.2 0.0 0.011 15.1 0.0 1.0 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) Glu_cys_ligase PF04262.9 ERZ98704.1 - 0.011 14.3 0.1 0.016 13.6 0.0 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase Nnf1 PF03980.9 ERZ98705.1 - 0.057 13.4 0.0 0.058 13.3 0.0 1.1 1 0 0 1 1 1 0 Nnf1 LRR_6 PF13516.1 ERZ98707.1 - 1.7e-06 27.4 0.1 0.0029 17.5 0.0 2.4 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.2 ERZ98707.1 - 0.00025 20.5 0.1 0.00055 19.4 0.0 1.6 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ98707.1 - 0.00054 19.6 0.1 0.22 11.6 0.0 2.5 2 0 0 2 2 2 2 Leucine Rich Repeat F-box-like PF12937.2 ERZ98707.1 - 0.00055 19.6 1.9 0.0015 18.2 1.3 1.8 1 1 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ERZ98707.1 - 0.00084 19.0 0.1 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_7 PF13504.1 ERZ98707.1 - 0.0048 16.8 0.1 3.1 8.4 0.0 2.8 2 0 0 2 2 2 1 Leucine rich repeat IMS PF00817.15 ERZ98709.1 - 9e-47 158.6 0.1 2e-46 157.5 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 ERZ98709.1 - 1.1e-14 54.4 0.3 3.8e-14 52.7 0.2 2.0 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 ERZ98709.1 - 0.00043 20.1 0.0 0.0011 18.9 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif zf-C2HC_2 PF13913.1 ERZ98709.1 - 0.088 12.5 2.1 0.13 11.9 0.4 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.1 ERZ98709.1 - 0.42 11.0 2.2 1.8 9.0 1.5 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger Tyr_Deacylase PF02580.11 ERZ98710.1 - 1.4e-44 151.5 0.1 1.6e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Prok-TraM PF09228.5 ERZ98710.1 - 0.0051 16.9 0.0 0.0086 16.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic Transcriptional repressor TraM JAB PF01398.16 ERZ98711.1 - 2.9e-15 56.0 0.0 4.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Acyl-CoA_dh_1 PF00441.19 ERZ98712.1 - 2.8e-49 167.0 2.7 4.8e-49 166.3 1.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ERZ98712.1 - 2.8e-27 95.5 0.3 5.7e-27 94.5 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ERZ98712.1 - 1.6e-21 75.5 0.5 7e-21 73.4 0.1 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ERZ98712.1 - 3.1e-17 63.0 0.5 6.4e-17 62.0 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 ERZ98712.1 - 5.8e-05 22.6 0.1 0.00022 20.6 0.1 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal PcrB PF01884.12 ERZ98712.1 - 0.053 12.7 0.1 0.16 11.2 0.0 1.7 2 0 0 2 2 2 0 PcrB family AAA-ATPase_like PF09820.4 ERZ98714.1 - 2.9e-06 26.6 0.1 3.1e-06 26.5 0.1 1.0 1 0 0 1 1 1 1 Predicted AAA-ATPase 3-HAO PF06052.7 ERZ98714.1 - 0.057 12.8 0.1 0.069 12.5 0.0 1.1 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase DUF3595 PF12166.3 ERZ98715.1 - 0.08 11.7 2.6 0.091 11.5 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) MCPVI PF02993.9 ERZ98715.1 - 0.25 11.4 8.2 0.27 11.3 5.7 1.0 1 0 0 1 1 1 0 Minor capsid protein VI Endostatin PF06482.6 ERZ98715.1 - 0.26 10.6 3.9 0.28 10.5 2.7 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Suf PF05843.9 ERZ98715.1 - 0.48 10.1 9.1 0.54 9.9 6.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TP53IP5 PF15331.1 ERZ98715.1 - 1.3 8.9 10.1 1.6 8.6 7.0 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF2413 PF10310.4 ERZ98715.1 - 6.4 5.4 15.5 7.5 5.2 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MOZ_SAS PF01853.13 ERZ98716.1 - 1.5e-76 255.8 1.9 4.1e-71 238.1 0.4 2.2 1 1 1 2 2 2 2 MOZ/SAS family Tudor-knot PF11717.3 ERZ98716.1 - 2.7e-16 59.0 0.8 5.7e-16 57.9 0.6 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 ERZ98716.1 - 0.047 13.3 0.3 0.35 10.5 0.1 2.4 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.27 ERZ98717.1 - 3e-35 118.8 2.4 7.1e-12 44.7 0.1 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.3 ERZ98717.1 - 0.00055 18.2 0.2 0.0039 15.4 0.1 2.3 2 1 1 3 3 3 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 ERZ98717.1 - 0.002 17.8 0.1 1.7 8.4 0.0 2.7 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.20 ERZ98718.1 - 3.7e-70 236.0 0.0 5e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98718.1 - 1.4e-53 181.6 0.0 1.8e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1241 PF06840.6 ERZ98718.1 - 8.8e-05 21.8 0.0 0.00019 20.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Kinase-like PF14531.1 ERZ98718.1 - 0.0002 20.4 0.0 0.0052 15.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 ERZ98718.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 SH3_9 PF14604.1 ERZ98720.1 - 2e-31 107.3 0.9 3.8e-15 55.1 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 ERZ98720.1 - 7.9e-28 95.5 1.2 2.7e-14 52.2 0.1 2.6 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.15 ERZ98720.1 - 4.2e-19 68.6 0.0 9.7e-19 67.5 0.0 1.7 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.12 ERZ98720.1 - 1.7e-17 62.6 0.0 3.7e-08 32.7 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain MIP-T3 PF10243.4 ERZ98720.1 - 0.005 15.3 58.5 0.0072 14.8 40.5 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 zf-AN1 PF01428.11 ERZ98721.1 - 9.1e-07 28.6 7.2 9.1e-07 28.6 5.0 2.3 2 1 1 3 3 3 1 AN1-like Zinc finger zf-A20 PF01754.11 ERZ98721.1 - 2.1e-06 27.1 8.0 6.1e-06 25.6 5.5 1.8 1 0 0 1 1 1 1 A20-like zinc finger DUF4588 PF15251.1 ERZ98721.1 - 0.16 11.8 2.8 0.2 11.6 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) zf-RING_4 PF14570.1 ERZ98721.1 - 7.6 6.2 13.6 4.5 6.9 3.4 2.9 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain COX7a PF02238.10 ERZ98722.1 - 0.023 14.4 0.4 0.043 13.5 0.3 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase subunit VIIa DUF2120 PF09893.4 ERZ98723.1 - 0.51 10.2 6.9 0.34 10.8 2.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Hep_59 PF07052.6 ERZ98723.1 - 1.7 9.0 9.8 19 5.6 0.1 2.8 2 1 1 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 DUF725 PF05267.7 ERZ98723.1 - 5.7 6.8 12.1 0.17 11.7 1.2 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF725) DFP PF04127.10 ERZ98724.1 - 3.2e-18 66.0 0.0 4.6e-10 39.3 0.0 2.5 1 1 1 2 2 2 2 DNA / pantothenate metabolism flavoprotein Orbi_NS3 PF01616.11 ERZ98724.1 - 0.047 12.6 0.1 0.08 11.8 0.1 1.3 1 0 0 1 1 1 0 Orbivirus NS3 Sterol_MT_C PF08498.5 ERZ98725.1 - 3.2e-24 84.6 0.0 5.1e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_31 PF13847.1 ERZ98725.1 - 6.7e-16 58.2 0.0 2.2e-15 56.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ98725.1 - 4e-15 56.0 0.0 3.1e-14 53.2 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.15 ERZ98725.1 - 5.1e-13 48.7 0.0 7.9e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 ERZ98725.1 - 3.4e-11 43.1 0.0 1.7e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ERZ98725.1 - 2.5e-10 40.5 0.0 5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ98725.1 - 5.3e-10 39.8 0.0 7.7e-09 36.1 0.0 2.5 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ98725.1 - 6.2e-09 36.2 0.1 1.8e-07 31.5 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ERZ98725.1 - 9.5e-06 25.6 0.0 3.1e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 ERZ98725.1 - 0.00012 21.6 0.0 0.00021 20.8 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Ubie_methyltran PF01209.13 ERZ98725.1 - 0.0013 17.8 0.0 0.0024 17.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 ERZ98725.1 - 0.0055 16.0 0.0 0.054 12.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain NodS PF05401.6 ERZ98725.1 - 0.081 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_2 PF00891.13 ERZ98725.1 - 0.093 11.9 0.0 0.19 10.8 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase 2OG-FeII_Oxy_2 PF13532.1 ERZ98726.1 - 1.2e-21 77.4 0.0 1.4e-21 77.2 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SopA_C PF13979.1 ERZ98728.1 - 0.026 14.1 0.2 0.037 13.6 0.1 1.2 1 0 0 1 1 1 0 SopA-like catalytic domain CDC37_N PF03234.9 ERZ98730.1 - 9e-45 153.1 21.6 9e-45 153.1 15.0 3.3 2 1 1 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 ERZ98730.1 - 7e-39 133.0 9.4 7e-39 133.0 6.5 3.5 2 1 1 3 3 3 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 ERZ98730.1 - 8.7e-19 67.2 0.3 8.7e-19 67.2 0.2 4.4 3 1 1 4 4 4 1 Cdc37 C terminal domain CENP-B_dimeris PF09026.5 ERZ98730.1 - 1.9 8.7 25.4 1.1 9.4 6.7 2.8 2 1 0 2 2 2 0 Centromere protein B dimerisation domain HABP4_PAI-RBP1 PF04774.10 ERZ98731.1 - 1.9e-08 34.7 2.0 2.3e-08 34.4 1.4 1.1 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family K_trans PF02705.11 ERZ98732.1 - 4e-198 659.1 19.2 4.7e-198 658.8 13.3 1.0 1 0 0 1 1 1 1 K+ potassium transporter Pirin_C PF05726.8 ERZ98733.1 - 1.6e-27 95.6 0.0 2.7e-27 94.8 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.11 ERZ98733.1 - 5.6e-06 26.1 0.1 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Pirin BTB PF00651.26 ERZ98734.1 - 1.8e-16 60.1 0.9 2.9e-16 59.4 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ98734.1 - 3.9e-06 26.6 4.6 3.8e-05 23.4 0.2 3.3 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ERZ98734.1 - 0.069 13.3 0.0 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain TIMELESS PF04821.9 ERZ98735.1 - 3.7e-11 42.7 8.0 3.7e-11 42.7 5.6 1.8 2 0 0 2 2 2 1 Timeless protein TIMELESS_C PF05029.8 ERZ98735.1 - 9.6e-11 41.3 0.2 1.7e-10 40.5 0.2 1.4 1 0 0 1 1 1 1 Timeless protein C terminal region COX6B PF02297.12 ERZ98735.1 - 0.094 12.7 1.5 5.2 7.1 0.1 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIb BTB PF00651.26 ERZ98736.1 - 4.7e-17 61.9 5.0 4.4e-16 58.8 0.0 3.2 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.10 ERZ98736.1 - 1.8e-10 40.5 2.1 7.7e-10 38.5 0.2 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ98737.1 - 2.7e-13 50.0 2.6 2.7e-13 50.0 1.8 1.7 2 0 0 2 2 2 1 TLD 5HT_transporter PF03491.8 ERZ98737.1 - 0.12 12.4 0.2 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Serotonin (5-HT) neurotransmitter transporter, N-terminus Pkinase_Tyr PF07714.12 ERZ98738.1 - 6.5e-40 136.8 0.0 8.8e-40 136.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98738.1 - 1.7e-38 132.2 0.5 3.3e-38 131.3 0.3 1.4 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ERZ98738.1 - 0.015 14.9 0.0 0.029 13.9 0.0 1.5 1 0 0 1 1 1 0 BCS1 N terminal APH PF01636.18 ERZ98738.1 - 0.22 11.2 0.1 0.45 10.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ERZ98740.1 - 0.003 17.2 5.5 0.081 12.6 0.4 2.4 2 0 0 2 2 2 2 F-box-like Lebercilin PF15619.1 ERZ98741.1 - 0.00096 18.6 22.2 0.0063 15.9 1.9 3.4 3 1 0 3 3 3 2 Ciliary protein causing Leber congenital amaurosis disease Rop-like PF05082.8 ERZ98741.1 - 0.0032 16.9 3.3 0.072 12.5 0.1 3.0 2 1 1 3 3 3 1 Rop-like DUF4527 PF15030.1 ERZ98741.1 - 0.012 14.8 0.9 0.019 14.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) Filament PF00038.16 ERZ98741.1 - 0.016 14.6 17.8 0.68 9.3 0.3 3.1 2 1 1 3 3 3 0 Intermediate filament protein MbeD_MobD PF04899.7 ERZ98741.1 - 0.068 13.0 1.7 6.5 6.7 0.1 2.7 2 1 0 2 2 2 0 MbeD/MobD like AAA_13 PF13166.1 ERZ98741.1 - 0.11 10.9 21.2 0.0064 15.0 7.0 2.1 2 0 0 2 2 2 0 AAA domain NDUFB10 PF10249.4 ERZ98741.1 - 0.11 12.5 0.2 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 Reo_sigmaC PF04582.7 ERZ98741.1 - 0.14 11.3 2.3 0.26 10.4 1.6 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein AHSP PF09236.5 ERZ98741.1 - 0.36 11.0 2.7 0.69 10.1 0.2 2.3 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein DUF4407 PF14362.1 ERZ98741.1 - 0.51 9.2 6.6 0.29 10.0 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FliD_N PF02465.13 ERZ98741.1 - 2.6 8.4 11.2 12 6.2 4.2 2.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ATG16 PF08614.6 ERZ98741.1 - 3.9 7.2 19.4 1.5 8.6 6.8 3.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) zf-CCHC PF00098.18 ERZ98743.1 - 0.00051 19.8 4.9 0.00099 18.9 3.4 1.5 1 0 0 1 1 1 1 Zinc knuckle Viral_cys_rich PF08008.7 ERZ98743.1 - 0.029 13.9 3.5 0.64 9.6 0.1 2.5 2 0 0 2 2 2 0 Viral cysteine rich zf-CCHC_4 PF14392.1 ERZ98743.1 - 0.12 12.0 1.7 0.28 10.8 1.2 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-ribbon_3 PF13248.1 ERZ98743.1 - 0.63 9.3 4.1 0.38 10.0 1.4 1.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-CCHC_6 PF15288.1 ERZ98743.1 - 1.2 8.8 11.7 1.2 8.9 6.9 1.9 2 0 0 2 2 2 0 Zinc knuckle Ras_bdg_2 PF14847.1 ERZ98744.1 - 0.089 12.7 0.1 0.097 12.6 0.1 1.1 1 0 0 1 1 1 0 Ras-binding domain of Byr2 Choline_kinase PF01633.15 ERZ98745.1 - 0.0037 16.8 1.6 0.038 13.5 1.1 2.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase HTH_Tnp_Tc5 PF03221.11 ERZ98745.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF4375 PF14300.1 ERZ98745.1 - 0.022 14.7 0.1 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) DUF2573 PF10835.3 ERZ98745.1 - 0.07 13.1 0.8 1.2 9.2 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2573) DUF1351 PF07083.6 ERZ98745.1 - 0.2 11.2 5.1 0.11 12.0 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1351) DUF4108 PF13390.1 ERZ98746.1 - 0.2 11.3 1.6 4.3 7.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) BTB PF00651.26 ERZ98747.1 - 7.3e-14 51.7 0.2 1.7e-13 50.4 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ98747.1 - 8.1e-12 45.3 0.7 1.4e-11 44.5 0.5 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ98747.1 - 2.8e-06 27.1 1.7 0.00014 21.6 0.3 3.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch Pkinase PF00069.20 ERZ98749.1 - 3.7e-59 199.9 0.0 4.8e-59 199.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98749.1 - 1.3e-32 112.8 0.0 1.7e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ERZ98749.1 - 8.5e-05 21.5 0.0 0.00017 20.5 0.0 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kinase-like PF14531.1 ERZ98749.1 - 0.0072 15.3 0.0 0.027 13.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like TEP1_N PF05386.6 ERZ98749.1 - 0.008 15.6 0.0 0.025 14.0 0.1 1.8 2 0 0 2 2 2 1 TEP1 N-terminal domain APH PF01636.18 ERZ98749.1 - 0.021 14.5 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PAZ_siRNAbind PF12212.3 ERZ98749.1 - 0.033 13.8 0.3 0.066 12.8 0.2 1.5 1 0 0 1 1 1 0 Piwi/Argonaute/Zwille siRNA-binding domain DEAD PF00270.24 ERZ98750.1 - 1.5e-43 148.1 0.4 4.7e-43 146.5 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ98750.1 - 9.7e-29 99.0 0.1 2e-28 98.0 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 ERZ98750.1 - 0.00034 20.3 0.1 0.00086 19.0 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 ERZ98750.1 - 0.0042 16.9 0.0 0.022 14.5 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 ERZ98750.1 - 0.0049 15.3 0.0 0.028 12.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) UvrD-helicase PF00580.16 ERZ98750.1 - 0.055 12.7 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 ERZ98750.1 - 0.055 13.6 0.6 0.25 11.5 0.4 2.0 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 ERZ98750.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_30 PF13604.1 ERZ98750.1 - 0.099 12.2 0.1 0.23 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.9 ERZ98750.1 - 0.15 11.7 0.2 0.44 10.2 0.1 2.0 1 1 1 2 2 2 0 Flavivirus DEAD domain G-patch PF01585.18 ERZ98754.1 - 1.4e-12 47.1 1.7 2.8e-12 46.2 1.2 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ERZ98754.1 - 0.00043 20.0 0.4 0.00043 20.0 0.3 2.1 2 0 0 2 2 2 1 DExH-box splicing factor binding site SF3b1 PF08920.5 ERZ98754.1 - 0.0097 15.9 6.1 0.0097 15.9 4.2 1.9 2 0 0 2 2 2 1 Splicing factor 3B subunit 1 Draxin PF15550.1 ERZ98754.1 - 4.8 6.7 10.0 19 4.7 6.9 1.8 1 1 0 1 1 1 0 Draxin WD40 PF00400.27 ERZ98755.1 - 3.1e-62 204.3 17.5 3.6e-11 42.4 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 ERZ98755.1 - 2.9e-13 49.9 0.1 7.7e-06 25.7 0.0 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ERZ98755.1 - 0.00084 17.5 2.4 0.42 8.6 0.1 3.1 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ERZ98755.1 - 0.0036 16.1 3.6 0.73 8.5 0.6 3.1 1 1 2 3 3 3 2 Nup133 N terminal like PD40 PF07676.7 ERZ98755.1 - 0.0096 15.5 0.1 11 5.8 0.0 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 ERZ98755.1 - 0.056 11.7 0.0 1.8 6.7 0.0 2.6 3 0 0 3 3 3 0 Cytochrome D1 heme domain PBP1_TM PF14812.1 ERZ98756.1 - 0.028 14.7 15.1 0.25 11.6 3.4 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Bd3614_N PF14442.1 ERZ98756.1 - 0.082 12.8 3.3 0.19 11.7 2.3 1.5 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Nucleoplasmin PF03066.10 ERZ98756.1 - 0.5 9.8 20.1 0.3 10.5 6.0 2.2 2 0 0 2 2 2 0 Nucleoplasmin TEX19 PF15553.1 ERZ98756.1 - 4.9 6.9 10.4 0.77 9.6 1.9 2.3 2 0 0 2 2 2 0 Testis-expressed protein 19 DDE_1 PF03184.14 ERZ98758.1 - 2e-09 36.8 0.4 5e-08 32.3 0.1 2.1 1 1 1 2 2 2 1 DDE superfamily endonuclease CENP-B_N PF04218.8 ERZ98758.1 - 0.0022 17.3 0.5 0.0064 15.8 0.0 2.1 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_10 PF04967.7 ERZ98758.1 - 0.01 15.3 0.0 0.059 12.9 0.0 2.2 2 0 0 2 2 2 0 HTH DNA binding domain Pkinase PF00069.20 ERZ98759.1 - 1.8e-27 96.1 3.8 6.1e-26 91.1 0.5 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98759.1 - 7.2e-15 54.7 0.9 1.8e-14 53.4 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ98759.1 - 8.6e-07 28.1 0.0 2.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ERZ98759.1 - 0.0059 15.6 0.1 0.012 14.7 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ98759.1 - 0.18 11.5 0.0 16 5.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF745 PF05335.8 ERZ98761.1 - 0.14 11.6 2.9 8.6 5.8 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF904 PF06005.7 ERZ98761.1 - 0.28 11.4 6.3 0.84 9.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF904) IncA PF04156.9 ERZ98761.1 - 0.52 9.8 9.8 4.5 6.8 0.7 2.7 2 0 0 2 2 2 0 IncA protein Pkinase_Tyr PF07714.12 ERZ98764.1 - 2.8e-12 46.2 0.0 3.9e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98764.1 - 5.2e-07 29.0 0.0 8.9e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Phage_int_SAM_3 PF14659.1 ERZ98764.1 - 0.12 12.6 0.7 0.12 12.6 0.5 1.9 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Sel1 PF08238.7 ERZ98765.1 - 5e-53 176.3 11.2 3.6e-12 46.5 0.0 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ98765.1 - 0.0056 17.0 6.0 6.5 7.4 0.0 5.0 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 ERZ98765.1 - 0.0067 15.5 0.2 0.099 11.6 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Flu_M1_C PF08289.6 ERZ98765.1 - 0.0096 15.9 0.0 3.9 7.5 0.0 2.7 2 1 1 3 3 3 2 Influenza Matrix protein (M1) C-terminal domain TPR_12 PF13424.1 ERZ98765.1 - 0.01 15.7 8.0 1.1 9.2 0.2 5.0 2 2 3 5 5 5 2 Tetratricopeptide repeat PPR_2 PF13041.1 ERZ98765.1 - 0.043 13.7 0.9 6.1 6.8 0.0 3.8 4 0 0 4 4 4 0 PPR repeat family MIT PF04212.13 ERZ98765.1 - 0.25 11.2 12.6 14 5.6 0.0 5.1 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain PPR PF01535.15 ERZ98765.1 - 0.35 10.9 1.8 17 5.6 0.0 4.0 4 0 0 4 4 4 0 PPR repeat IMD PF08397.6 ERZ98766.1 - 0.039 13.2 2.6 0.05 12.9 1.8 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF3546 PF12066.3 ERZ98766.1 - 0.067 13.2 2.0 0.087 12.8 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) DUF3231 PF11553.3 ERZ98766.1 - 0.072 12.5 0.3 0.11 11.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3231) DUF2603 PF10788.4 ERZ98766.1 - 0.078 12.7 0.4 0.082 12.6 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2603) DUF615 PF04751.9 ERZ98766.1 - 0.13 11.9 3.7 0.23 11.0 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF615) MCR_beta_N PF02783.10 ERZ98767.1 - 0.15 11.5 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain Pkinase PF00069.20 ERZ98768.1 - 5.6e-13 48.6 0.2 7.1e-13 48.2 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98768.1 - 3.2e-10 39.5 0.1 4e-10 39.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ERZ98769.1 - 4.9e-55 182.7 14.7 1.7e-11 44.3 0.1 6.2 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ98769.1 - 0.00031 20.9 4.7 6.5 7.4 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ERZ98769.1 - 0.0024 17.5 0.3 0.36 10.6 0.0 2.6 2 0 0 2 2 2 2 Aurora-A binding DUF1563 PF07599.6 ERZ98771.1 - 0.049 13.5 7.0 0.061 13.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) CRT-like PF08627.5 ERZ98772.1 - 0.049 13.5 1.1 0.047 13.6 0.8 1.0 1 0 0 1 1 1 0 CRT-like Adaptin_N PF01602.15 ERZ98773.1 - 1.3e-145 485.7 11.1 1.6e-145 485.4 7.7 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 ERZ98773.1 - 2e-29 102.6 7.5 4.6e-28 98.2 0.2 3.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ERZ98773.1 - 3.6e-18 65.6 0.5 1.6e-09 37.9 0.0 4.7 2 2 4 6 6 6 4 HEAT repeats HEAT PF02985.17 ERZ98773.1 - 3e-10 39.2 0.2 0.024 14.6 0.0 5.5 6 0 0 6 6 5 2 HEAT repeat HEAT_EZ PF13513.1 ERZ98773.1 - 7.2e-07 29.5 0.6 0.28 11.7 0.0 4.9 5 1 0 5 5 5 2 HEAT-like repeat Arm PF00514.18 ERZ98773.1 - 2.8e-06 26.9 2.7 0.022 14.5 0.0 4.7 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 ERZ98773.1 - 3.5e-05 23.2 0.8 0.3 10.3 0.0 4.2 2 1 1 4 4 4 2 CLASP N terminal RIX1 PF08167.7 ERZ98773.1 - 0.00053 19.7 0.3 0.38 10.4 0.0 3.2 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis Arm_2 PF04826.8 ERZ98773.1 - 0.0015 17.6 1.9 0.012 14.7 0.1 2.6 1 1 0 2 2 2 1 Armadillo-like FadR_C PF07840.7 ERZ98773.1 - 0.049 13.2 1.4 2.3 7.8 0.0 3.0 3 0 0 3 3 3 0 FadR C-terminal domain FANCI_S2 PF14676.1 ERZ98773.1 - 0.05 13.4 2.8 0.71 9.7 0.0 3.2 3 1 0 3 3 3 0 FANCI solenoid 2 DDT PF02791.12 ERZ98776.1 - 0.016 14.9 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 DDT domain Ion_trans PF00520.26 ERZ98779.1 - 1.7e-15 56.7 22.5 1.7e-15 56.7 15.6 2.1 2 1 0 2 2 2 1 Ion transport protein RcbX PF02341.10 ERZ98779.1 - 0.03 14.4 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 RbcX protein DUF673 PF05054.7 ERZ98780.1 - 0.044 12.3 0.1 0.05 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF673) DUF3979 PF13141.1 ERZ98780.1 - 0.1 12.4 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3979) Pheromone PF08015.6 ERZ98783.1 - 0.049 14.4 5.9 0.11 13.3 4.1 1.6 1 0 0 1 1 1 0 Fungal mating-type pheromone Atrophin-1 PF03154.10 ERZ98783.1 - 0.31 9.1 7.7 0.43 8.6 5.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family Ashwin PF15323.1 ERZ98783.1 - 0.36 10.8 7.6 0.61 10.0 5.2 1.3 1 0 0 1 1 1 0 Developmental protein Herpes_capsid PF06112.6 ERZ98783.1 - 0.42 10.6 12.1 0.73 9.8 8.4 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Period_C PF12114.3 ERZ98783.1 - 0.83 9.2 10.8 1.5 8.3 7.5 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Med3 PF11593.3 ERZ98783.1 - 2.5 7.2 13.5 3.4 6.8 9.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SSP160 PF06933.6 ERZ98783.1 - 3 5.6 21.1 4.3 5.1 14.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CAF-1_p150 PF11600.3 ERZ98783.1 - 5.1 6.4 8.8 8.7 5.6 6.1 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Cullin PF00888.17 ERZ98784.1 - 1.6e-81 274.6 18.8 2.9e-81 273.7 13.0 1.3 1 0 0 1 1 1 1 Cullin family BTB PF00651.26 ERZ98784.1 - 1e-15 57.6 0.0 3.8e-15 55.8 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain Cullin_Nedd8 PF10557.4 ERZ98784.1 - 9.9e-14 50.9 0.4 2.8e-13 49.4 0.3 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF4186 PF13811.1 ERZ98786.1 - 0.12 12.0 0.5 0.19 11.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4186) Asp_protease_2 PF13650.1 ERZ98787.1 - 7.5e-10 39.1 0.2 1.1e-09 38.6 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 ERZ98787.1 - 5.7e-08 32.3 0.2 8.2e-08 31.8 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ERZ98787.1 - 2.4e-07 30.7 0.0 3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 ERZ98787.1 - 5.6e-07 29.4 0.9 9.5e-07 28.6 0.6 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ERZ98787.1 - 2.7e-05 23.9 0.0 4.4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Na_trans_assoc PF06512.8 ERZ98787.1 - 0.034 14.1 10.2 0.035 14.0 7.0 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated zf-H2C2 PF09337.5 ERZ98788.1 - 0.13 11.6 0.0 1.4 8.4 0.2 2.0 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger YkuI_C PF10388.4 ERZ98789.1 - 0.025 14.2 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain Sel1 PF08238.7 ERZ98790.1 - 4.6e-76 249.5 48.1 2.8e-11 43.6 0.6 9.0 9 0 0 9 9 9 8 Sel1 repeat TPR_7 PF13176.1 ERZ98790.1 - 0.00025 20.6 4.1 1.8 8.5 0.1 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ98790.1 - 0.001 19.3 18.3 1 9.9 0.0 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ98790.1 - 0.0039 17.7 0.1 37 5.3 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ98790.1 - 0.048 13.3 29.8 0.082 12.5 3.3 5.6 2 2 2 5 5 5 0 TPR repeat TPR_12 PF13424.1 ERZ98790.1 - 0.18 11.7 13.8 3 7.8 0.6 5.4 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ98790.1 - 0.46 11.2 6.9 25 5.6 0.0 4.8 4 3 1 5 5 5 0 Tetratricopeptide repeat C2 PF00168.25 ERZ98791.1 - 1.6e-24 85.5 0.3 1.9e-24 85.2 0.2 1.0 1 0 0 1 1 1 1 C2 domain DUF290 PF01060.18 ERZ98791.1 - 0.052 13.5 1.0 0.091 12.7 0.2 1.9 1 1 0 2 2 2 0 Transthyretin-like family C2 PF00168.25 ERZ98792.1 - 2.2e-09 37.0 0.3 2.6e-09 36.8 0.2 1.1 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.1 ERZ98792.1 - 0.13 11.8 0.0 0.14 11.6 0.0 1.4 1 1 0 1 1 1 0 CEP76 C2 domain C2 PF00168.25 ERZ98793.1 - 1.3e-21 76.2 0.8 1.7e-21 75.8 0.6 1.1 1 0 0 1 1 1 1 C2 domain Sld5 PF05916.6 ERZ98796.1 - 2.6e-05 24.4 0.4 3.8e-05 23.9 0.3 1.3 1 0 0 1 1 1 1 GINS complex protein PY_rept_46 PF09689.5 ERZ98796.1 - 1.1 9.6 3.7 6.6 7.1 1.0 2.3 2 0 0 2 2 2 0 Plasmodium yoelii repeat (PY_rept_46) DUF2024 PF09630.5 ERZ98797.1 - 0.04 13.6 0.2 0.065 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) DDE_3 PF13358.1 ERZ98799.1 - 3.9e-06 26.6 0.0 5.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ERZ98804.1 - 2.7e-06 27.2 0.0 4.1e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease CBM49 PF09478.5 ERZ98804.1 - 0.066 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 PD40 PF07676.7 ERZ98805.1 - 0.047 13.3 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat DUF3110 PF11360.3 ERZ98805.1 - 0.11 12.3 0.1 5.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3110) PBP1_TM PF14812.1 ERZ98805.1 - 5.8 7.2 7.5 8.5 6.7 4.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CBM_X PF06204.6 ERZ98806.1 - 0.051 13.0 0.0 6.5 6.3 0.0 2.9 3 0 0 3 3 3 0 Putative carbohydrate binding domain DDE_Tnp_ISAZ013 PF07592.6 ERZ98807.1 - 5.2e-05 22.1 0.0 0.034 12.9 0.0 2.3 2 1 0 2 2 2 2 Rhodopirellula transposase DDE domain zf-C2H2_6 PF13912.1 ERZ98807.1 - 0.018 14.9 2.3 0.033 14.1 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ERZ98807.1 - 0.019 15.2 2.3 0.019 15.2 1.6 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ98807.1 - 0.022 15.0 1.8 0.022 15.0 1.3 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_pol_B PF00136.16 ERZ98811.1 - 4.8e-56 190.4 4.5 7e-56 189.9 3.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ERZ98811.1 - 2e-20 72.8 3.0 4.8e-20 71.6 2.1 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 ERZ98812.1 - 3.9e-47 161.1 6.9 5e-47 160.7 4.8 1.1 1 0 0 1 1 1 1 DNA polymerase family B ATP-cone PF03477.11 ERZ98812.1 - 0.037 14.4 0.5 0.59 10.5 0.1 2.3 2 0 0 2 2 2 0 ATP cone domain Spc7 PF08317.6 ERZ98813.1 - 0.023 13.3 0.4 0.029 13.0 0.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Laminin_I PF06008.9 ERZ98813.1 - 0.046 13.0 0.1 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Laminin Domain I DNA_pol_B PF00136.16 ERZ98814.1 - 2.5e-67 227.7 3.9 5e-67 226.6 2.7 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ERZ98814.1 - 1.6e-21 76.5 1.8 3.2e-21 75.5 1.2 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Asp PF00026.18 ERZ98815.1 - 1.2e-58 198.8 1.8 1.4e-58 198.6 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 ERZ98815.1 - 0.00023 20.7 0.1 0.00087 18.8 0.0 1.9 2 1 0 3 3 3 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 ERZ98815.1 - 0.028 14.3 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor N-terminal DUF1068 PF06364.7 ERZ98817.1 - 0.013 15.1 0.7 0.017 14.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Pkinase_Tyr PF07714.12 ERZ98819.1 - 3.7e-25 88.4 0.0 9.2e-25 87.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98819.1 - 3.8e-24 85.2 0.2 7.7e-24 84.2 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain eIF-5_eIF-2B PF01873.12 ERZ98819.1 - 0.043 13.4 1.1 0.14 11.8 0.8 1.8 1 1 0 1 1 1 0 Domain found in IF2B/IF5 Ras PF00071.17 ERZ98821.1 - 2.9e-55 186.0 0.0 3.3e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ98821.1 - 7e-18 65.2 0.0 9.9e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ERZ98821.1 - 2e-07 30.4 0.0 2.6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Rgp1 PF08737.5 ERZ98826.1 - 5.7e-37 127.7 0.0 7.9e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Rgp1 Grp1_Fun34_YaaH PF01184.14 ERZ98828.1 - 1.5e-71 240.0 14.4 1.7e-71 239.8 10.0 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF202 PF02656.10 ERZ98828.1 - 4.6 7.5 16.1 8.6 6.6 1.3 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF202) Asp PF00026.18 ERZ98831.1 - 8.2e-74 248.6 2.3 8.2e-74 248.6 1.6 1.5 2 0 0 2 2 2 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 ERZ98831.1 - 2.6e-07 31.0 0.8 0.0026 18.2 0.1 3.2 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.1 ERZ98831.1 - 0.00048 19.9 0.1 0.0039 16.9 0.0 2.1 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 ERZ98831.1 - 0.00075 19.3 0.4 0.13 12.2 0.0 2.9 3 0 0 3 3 3 1 Retroviral aspartyl protease DPCD PF14913.1 ERZ98834.1 - 0.12 11.4 0.9 0.15 11.1 0.6 1.1 1 0 0 1 1 1 0 DPCD protein family Chordopox_A13L PF05961.6 ERZ98834.1 - 0.64 9.9 2.5 0.79 9.7 1.2 1.5 1 1 0 1 1 1 0 Chordopoxvirus A13L protein DUF4548 PF15081.1 ERZ98835.1 - 0.07 12.6 0.8 0.11 12.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Baculo_LEF5_C PF11792.3 ERZ98835.1 - 7.5 6.0 7.1 3.9 6.9 0.5 2.4 1 1 1 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain V_ATPase_I PF01496.14 ERZ98841.1 - 0.14 9.9 7.0 0.22 9.3 4.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4446 PF14584.1 ERZ98841.1 - 0.31 10.8 6.2 1.1 9.0 3.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Transformer PF06495.6 ERZ98841.1 - 4.6 7.0 6.8 1 9.1 1.9 1.8 2 0 0 2 2 2 0 Fruit fly transformer protein Sel1 PF08238.7 ERZ98842.1 - 3.9e-47 157.6 9.9 9.6e-12 45.1 0.4 6.9 7 0 0 7 7 7 6 Sel1 repeat MIT PF04212.13 ERZ98842.1 - 0.0038 17.0 11.0 9.1 6.2 0.1 4.9 3 1 2 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ERZ98842.1 - 0.004 17.5 4.7 2.4 8.7 0.3 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat NSF PF02071.15 ERZ98842.1 - 0.15 12.6 5.6 42 5.3 0.1 5.9 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Sel1 PF08238.7 ERZ98843.1 - 4e-76 249.7 25.5 5.7e-12 45.8 0.6 11.1 11 0 0 11 11 11 11 Sel1 repeat MIT PF04212.13 ERZ98843.1 - 0.12 12.2 22.0 2.6 7.9 0.6 7.3 8 1 0 8 8 8 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ERZ98844.1 - 1.7e-24 85.6 5.0 1.9e-07 31.4 0.0 3.7 3 1 1 4 4 4 3 Sel1 repeat MIT PF04212.13 ERZ98844.1 - 0.0063 16.3 5.4 0.56 10.1 0.1 3.7 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ERZ98844.1 - 0.019 15.4 3.2 22 5.7 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ98844.1 - 0.18 11.7 8.5 21 5.1 1.7 4.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.11 ERZ98844.1 - 4.2 7.2 0.0 4.2 7.2 0.0 3.6 5 0 0 5 5 5 0 Exonuclease VII small subunit TPR_2 PF07719.12 ERZ98844.1 - 5.4 7.1 13.5 1.2e+02 2.9 0.2 6.3 6 1 0 7 7 7 0 Tetratricopeptide repeat PWI PF01480.12 ERZ98846.1 - 6.8e-28 96.5 0.0 1.2e-27 95.8 0.0 1.4 1 0 0 1 1 1 1 PWI domain Helicase_C PF00271.26 ERZ98847.1 - 2.2e-12 46.6 0.0 4.6e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ERZ98847.1 - 2.9e-08 33.3 0.0 8.1e-08 31.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.18 ERZ98847.1 - 2.7e-07 30.5 0.0 8.2e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_22 PF13401.1 ERZ98847.1 - 0.0013 18.9 0.0 0.0032 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ERZ98847.1 - 0.043 12.9 0.0 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.1 ERZ98847.1 - 0.078 12.7 0.1 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 ERZ98847.1 - 0.49 10.3 2.9 2.3 8.1 0.0 3.0 2 1 0 2 2 2 0 AAA domain GTP_cyclohydro2 PF00925.15 ERZ98848.1 - 3e-66 221.8 0.0 4.4e-59 198.5 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II LSM PF01423.17 ERZ98849.1 - 9e-18 63.5 0.2 1.1e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Flag1_repress PF03614.8 ERZ98849.1 - 0.0086 15.6 0.0 0.0087 15.6 0.0 1.2 1 0 0 1 1 1 1 Repressor of phase-1 flagellin SM-ATX PF14438.1 ERZ98849.1 - 0.096 12.6 0.1 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Sel1 PF08238.7 ERZ98850.1 - 1.9e-09 37.8 7.7 0.032 14.8 0.9 3.7 3 1 0 3 3 3 3 Sel1 repeat Mg296 PF09644.5 ERZ98850.1 - 0.062 13.1 0.1 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 Mg296 protein NSF PF02071.15 ERZ98850.1 - 1 10.1 0.1 1 10.1 0.1 2.8 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat Pkinase PF00069.20 ERZ98851.1 - 4.1e-35 121.1 1.5 5.4e-35 120.7 1.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98851.1 - 8.3e-34 116.8 0.1 1.1e-33 116.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ98851.1 - 0.0019 17.2 0.0 0.0027 16.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF899 PF05988.7 ERZ98852.1 - 0.23 10.8 0.6 0.21 10.9 0.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) DUF3040 PF11239.3 ERZ98852.1 - 1.5 8.9 7.5 1.6 8.7 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) ABC_membrane_2 PF06472.10 ERZ98853.1 - 0.04 13.0 0.1 0.043 12.9 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Pkinase_Tyr PF07714.12 ERZ98853.1 - 0.053 12.5 0.1 0.11 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Fib_alpha PF08702.5 ERZ98853.1 - 0.057 13.5 1.6 0.069 13.2 1.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family UvsY PF11056.3 ERZ98854.1 - 0.042 13.9 2.7 2.4 8.2 0.1 2.8 3 0 0 3 3 3 0 Recombination, repair and ssDNA binding protein UvsY Pkinase PF00069.20 ERZ98856.1 - 1.2e-12 47.5 0.2 1.4e-12 47.3 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98856.1 - 7.1e-10 38.3 0.0 9e-10 38.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ98857.1 - 3.7e-05 22.9 0.0 4.5e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98857.1 - 0.0005 19.2 0.1 0.0006 19.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF2874 PF11396.3 ERZ98857.1 - 0.087 12.8 2.7 0.085 12.8 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) Pkinase PF00069.20 ERZ98858.1 - 8.1e-11 41.5 0.2 9.1e-11 41.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98858.1 - 4.5e-09 35.7 0.0 5e-09 35.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1680 PF07944.7 ERZ98858.1 - 0.073 11.3 0.1 2.5 6.2 0.1 2.0 1 1 1 2 2 2 0 Putative glycosyl hydrolase of unknown function (DUF1680) DUF1119 PF06550.6 ERZ98859.1 - 4.5 6.3 12.7 0.73 8.9 6.2 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1119) PPC PF04151.10 ERZ98860.1 - 0.067 14.1 0.1 0.21 12.5 0.0 1.8 1 1 1 2 2 2 0 Bacterial pre-peptidase C-terminal domain UDP-g_GGTase PF06427.6 ERZ98861.1 - 4.7e-63 212.2 0.1 2.1e-62 210.1 0.1 2.0 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 ERZ98861.1 - 5.5e-08 32.4 0.0 1.5e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 8 Pkinase_Tyr PF07714.12 ERZ98862.1 - 4.7e-08 32.4 0.1 5.7e-07 28.8 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98862.1 - 0.0012 18.0 0.3 0.002 17.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain GBP_repeat PF02526.9 ERZ98862.1 - 0.022 14.1 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Glycophorin-binding protein Apc3 PF12895.2 ERZ98862.1 - 0.12 12.5 0.3 0.48 10.5 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Mei5 PF10376.4 ERZ98863.1 - 8.3e-13 48.3 4.0 1e-12 48.0 2.8 1.3 1 0 0 1 1 1 1 Double-strand recombination repair protein GET2 PF08690.5 ERZ98863.1 - 0.047 12.9 1.5 0.066 12.4 1.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF342 PF03961.8 ERZ98863.1 - 0.099 11.0 1.5 0.16 10.3 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF241 PF03087.9 ERZ98863.1 - 0.16 11.3 3.9 0.29 10.6 2.7 1.4 1 1 0 1 1 1 0 Arabidopsis protein of unknown function Ax_dynein_light PF10211.4 ERZ98863.1 - 1 9.1 7.0 0.27 11.0 1.8 2.0 2 0 0 2 2 2 0 Axonemal dynein light chain ACCA PF03255.9 ERZ98863.1 - 3.5 7.1 5.2 0.47 9.9 0.9 1.6 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit NuA4 PF09340.5 ERZ98863.1 - 5.9 6.6 8.8 22 4.7 6.1 2.1 1 1 0 1 1 1 0 Histone acetyltransferase subunit NuA4 SNARE_assoc PF09335.6 ERZ98864.1 - 9.6e-17 61.3 13.7 1e-16 61.2 7.0 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein PgaD PF13994.1 ERZ98864.1 - 0.00017 21.0 0.2 0.0003 20.2 0.1 1.4 1 0 0 1 1 1 1 PgaD-like protein DUF2910 PF11139.3 ERZ98864.1 - 0.0052 15.9 0.2 0.018 14.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2910) Srg PF02118.16 ERZ98864.1 - 0.024 14.0 3.6 0.019 14.3 1.7 1.4 1 1 0 1 1 1 0 Srg family chemoreceptor DUF2919 PF11143.3 ERZ98864.1 - 0.08 12.7 1.1 0.18 11.6 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2919) MpPF26 PF07666.6 ERZ98864.1 - 4.5 7.1 7.5 0.37 10.6 0.9 2.3 3 0 0 3 3 3 0 M penetrans paralogue family 26 Clathrin PF00637.15 ERZ98865.1 - 4.9e-18 65.1 21.3 6.6e-17 61.4 4.0 4.6 5 0 0 5 5 5 2 Region in Clathrin and VPS VPS11_C PF12451.3 ERZ98865.1 - 2.9e-16 59.0 1.8 5.1e-16 58.2 0.5 2.0 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.1 ERZ98865.1 - 0.023 14.7 6.6 0.053 13.5 4.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) A_deaminase_N PF08451.6 ERZ98865.1 - 0.023 14.7 0.1 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Adenosine/AMP deaminase N-terminal zf-RING_5 PF14634.1 ERZ98865.1 - 0.027 14.1 6.7 0.053 13.2 4.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 ERZ98865.1 - 0.041 13.7 7.9 0.11 12.3 5.4 1.7 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.2 ERZ98865.1 - 0.27 11.3 3.1 0.58 10.3 2.1 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger Thioredoxin PF00085.15 ERZ98866.1 - 1.2e-67 224.0 9.6 1.8e-32 111.0 0.2 4.4 4 1 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.1 ERZ98866.1 - 5.1e-50 169.8 16.0 5.6e-39 133.8 3.2 3.9 3 2 2 5 5 5 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 ERZ98866.1 - 3.4e-14 53.0 4.0 7.9e-07 29.2 0.1 4.7 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ERZ98866.1 - 2.2e-13 50.0 0.0 2.3e-05 24.3 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_8 PF13905.1 ERZ98866.1 - 9.1e-11 41.7 2.2 0.0021 18.1 0.0 4.6 3 2 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.16 ERZ98866.1 - 8.1e-09 35.2 1.7 0.0037 16.9 0.0 3.0 2 1 0 2 2 2 2 AhpC/TSA family Calsequestrin PF01216.12 ERZ98866.1 - 4.9e-08 32.1 13.4 4.9e-08 32.1 4.1 2.6 1 1 0 2 2 2 2 Calsequestrin Redoxin PF08534.5 ERZ98866.1 - 6.9e-06 25.6 2.4 0.014 14.9 0.0 2.8 3 0 0 3 3 3 2 Redoxin Thioredoxin_4 PF13462.1 ERZ98866.1 - 4.9e-05 23.3 2.3 0.6 10.1 0.1 3.8 3 2 1 4 4 4 2 Thioredoxin ERp29_N PF07912.8 ERZ98866.1 - 0.0045 16.9 2.3 0.17 11.7 0.1 3.9 3 1 1 4 4 4 1 ERp29, N-terminal domain Thioredoxin_9 PF14595.1 ERZ98866.1 - 0.0074 15.8 0.2 2 7.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin DUF4035 PF13227.1 ERZ98867.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4035) Amino_oxidase PF01593.19 ERZ98869.1 - 5.5e-45 154.2 0.0 5.1e-31 108.2 0.0 2.0 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 ERZ98869.1 - 3.4e-14 52.6 0.0 1.1e-13 50.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 ERZ98869.1 - 3.9e-05 22.8 0.2 5.6e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.1 ERZ98869.1 - 0.0001 22.1 0.0 0.042 13.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.9 ERZ98869.1 - 0.00038 19.0 0.4 0.00072 18.1 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.19 ERZ98869.1 - 0.00043 19.2 0.2 0.00066 18.6 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 ERZ98869.1 - 0.00054 20.3 0.0 0.0012 19.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ERZ98869.1 - 0.00089 18.4 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 ERZ98869.1 - 0.0018 17.2 0.2 0.0029 16.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ERZ98869.1 - 0.0042 16.9 0.0 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ERZ98869.1 - 0.01 15.8 0.0 0.038 14.0 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ERZ98869.1 - 0.015 14.2 0.1 0.024 13.5 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 ERZ98869.1 - 0.025 14.1 0.0 0.043 13.3 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.2 ERZ98869.1 - 0.03 13.3 0.0 0.05 12.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.13 ERZ98869.1 - 0.22 11.1 0.0 1.1 8.8 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TLD PF07534.11 ERZ98870.1 - 7e-13 48.7 0.4 1e-12 48.2 0.3 1.3 1 0 0 1 1 1 1 TLD Yip1 PF04893.12 ERZ98871.1 - 0.0061 16.0 0.1 0.31 10.5 0.0 2.2 2 1 0 2 2 2 2 Yip1 domain DUF2839 PF10999.3 ERZ98871.1 - 0.55 10.2 0.1 0.55 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) Med19 PF10278.4 ERZ98872.1 - 0.48 10.0 4.5 0.5 10.0 3.1 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Cut8_N PF14482.1 ERZ98872.1 - 0.59 10.1 2.8 0.7 9.9 2.0 1.2 1 0 0 1 1 1 0 Cut8 proteasome-binding domain PH PF00169.24 ERZ98873.1 - 1.1e-12 48.1 1.4 1.1e-12 48.1 1.0 3.0 3 2 0 3 3 3 1 PH domain PH_3 PF14593.1 ERZ98873.1 - 1.2e-07 31.5 0.5 2.4e-07 30.5 0.4 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 ERZ98873.1 - 4.9e-06 26.5 0.2 4.9e-06 26.5 0.2 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.1 ERZ98873.1 - 0.53 10.5 0.1 0.13 12.5 0.4 4.3 4 2 1 6 6 6 0 Pleckstrin homology domain MscL PF01741.13 ERZ98874.1 - 0.0038 17.3 2.2 0.0038 17.3 1.5 1.5 2 0 0 2 2 2 1 Large-conductance mechanosensitive channel, MscL TMEM154 PF15102.1 ERZ98874.1 - 0.035 13.8 0.2 0.073 12.7 0.1 1.5 1 0 0 1 1 1 0 TMEM154 protein family MgtE PF01769.11 ERZ98874.1 - 0.069 13.4 5.6 1.3 9.3 2.6 2.1 2 0 0 2 2 2 0 Divalent cation transporter Kei1 PF08552.6 ERZ98874.1 - 0.12 11.9 8.3 1.7 8.2 5.8 2.4 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PHO4 PF01384.15 ERZ98874.1 - 0.13 10.9 4.4 0.32 9.5 3.0 1.7 1 1 0 1 1 1 0 Phosphate transporter family DUF2611 PF11022.3 ERZ98874.1 - 1.7 8.8 4.4 26 4.9 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2611) EphA2_TM PF14575.1 ERZ98874.1 - 2.4 8.6 4.7 1.2 9.5 0.1 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Tetraspannin PF00335.15 ERZ98875.1 - 0.021 14.1 18.1 0.38 9.9 12.5 2.0 1 1 0 1 1 1 0 Tetraspanin family PspB PF06667.7 ERZ98875.1 - 9.2 6.2 6.7 4.2 7.3 0.2 2.8 2 1 0 2 2 2 0 Phage shock protein B HPD PF05044.7 ERZ98876.1 - 0.2 11.2 2.0 0.34 10.5 1.2 1.7 1 1 0 1 1 1 0 Homeo-prospero domain DUF1764 PF08576.5 ERZ98876.1 - 1.4 9.7 5.9 1.9 9.2 4.1 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) LRR_4 PF12799.2 ERZ98877.1 - 1.9e-05 24.1 19.3 0.048 13.2 0.0 5.3 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ98877.1 - 0.0015 18.2 11.0 0.024 14.3 0.5 3.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_7 PF13504.1 ERZ98877.1 - 0.003 17.4 0.8 12 6.6 0.0 4.9 4 0 0 4 4 4 1 Leucine rich repeat LRR_6 PF13516.1 ERZ98877.1 - 0.18 11.9 18.8 2.8 8.2 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.28 ERZ98877.1 - 0.2 11.7 5.0 14 6.2 0.2 4.8 3 2 0 3 3 3 0 Leucine Rich Repeat DUF3391 PF11871.3 ERZ98879.1 - 0.27 11.4 5.8 0.3 11.2 3.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3391) Sec20 PF03908.8 ERZ98879.1 - 0.33 10.6 8.6 1.3 8.7 3.4 2.6 2 0 0 2 2 2 0 Sec20 Exo_endo_phos PF03372.18 ERZ98880.1 - 0.00067 19.6 0.0 0.00079 19.4 0.0 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RBD-FIP PF09457.5 ERZ98880.1 - 0.1 12.4 2.1 0.26 11.0 1.1 1.9 1 1 1 2 2 2 0 FIP domain FIVAR PF07554.8 ERZ98880.1 - 0.12 12.6 2.5 0.19 11.9 1.7 1.3 1 0 0 1 1 1 0 Uncharacterised Sugar-binding Domain TLD PF07534.11 ERZ98881.1 - 1.1e-06 28.6 2.7 1.3e-06 28.4 1.9 1.1 1 0 0 1 1 1 1 TLD SID PF11778.3 ERZ98883.1 - 0.0026 17.6 1.7 0.19 11.6 0.1 2.1 2 0 0 2 2 2 2 Septation initiation TMPIT PF07851.8 ERZ98884.1 - 0.027 13.5 2.7 0.032 13.2 1.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein Swi5 PF07061.6 ERZ98884.1 - 0.045 13.5 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Swi5 ApoLp-III PF07464.6 ERZ98884.1 - 0.049 13.6 1.7 0.071 13.1 1.2 1.2 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Ub-RnfH PF03658.9 ERZ98886.1 - 0.088 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 RnfH family Ubiquitin HopJ PF08888.6 ERZ98888.1 - 0.17 11.9 0.2 0.17 11.9 0.1 2.0 2 0 0 2 2 2 0 HopJ type III effector protein USP7_C2 PF14533.1 ERZ98891.1 - 3.1e-55 186.9 7.8 3.1e-55 186.9 5.4 1.8 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.3 ERZ98891.1 - 4.4e-54 183.3 10.2 2.4e-50 171.0 0.4 3.9 3 1 1 4 4 4 3 ICP0-binding domain of Ubiquitin-specific protease 7 FliP PF00813.15 ERZ98892.1 - 0.0063 16.2 0.6 0.0084 15.8 0.4 1.3 1 0 0 1 1 1 1 FliP family Symplekin_C PF12295.3 ERZ98892.1 - 0.065 13.1 2.9 0.11 12.3 2.0 1.4 1 1 0 1 1 1 0 Symplekin tight junction protein C terminal CAF1 PF04857.15 ERZ98893.1 - 0.13 11.5 0.1 0.13 11.5 0.1 1.0 1 0 0 1 1 1 0 CAF1 family ribonuclease DUF3447 PF11929.3 ERZ98893.1 - 2 8.2 5.0 0.47 10.2 0.8 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) Seryl_tRNA_N PF02403.17 ERZ98895.1 - 0.0036 17.3 3.4 0.0036 17.3 2.4 3.1 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Rop-like PF05082.8 ERZ98895.1 - 0.021 14.2 3.9 0.091 12.2 0.2 2.8 2 0 0 2 2 2 0 Rop-like DUF106 PF01956.11 ERZ98895.1 - 0.045 13.2 0.0 0.62 9.5 0.0 2.5 1 1 0 1 1 1 0 Integral membrane protein DUF106 Gp58 PF07902.6 ERZ98895.1 - 0.052 11.7 6.4 0.067 11.4 4.5 1.1 1 0 0 1 1 1 0 gp58-like protein Peptidase_S46 PF10459.4 ERZ98895.1 - 0.13 10.6 9.3 0.011 14.2 2.2 1.8 1 1 0 1 1 1 0 Peptidase S46 DUF1664 PF07889.7 ERZ98895.1 - 0.29 10.9 8.3 3.9 7.2 4.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 ERZ98895.1 - 0.9 7.9 25.1 1.2 7.5 10.7 2.0 1 1 1 2 2 2 0 AAA domain FliD_N PF02465.13 ERZ98895.1 - 1.1 9.7 9.1 2.1 8.7 4.5 2.5 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Fib_alpha PF08702.5 ERZ98895.1 - 1.4 9.0 17.3 1.2 9.2 6.9 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.1 ERZ98895.1 - 1.7 7.5 12.9 3.8 6.3 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Tup_N PF08581.5 ERZ98895.1 - 4.6 7.5 17.8 0.12 12.6 4.8 2.9 3 1 0 3 3 3 0 Tup N-terminal bZIP_1 PF00170.16 ERZ98896.1 - 0.095 12.6 0.3 0.095 12.6 0.2 2.5 3 0 0 3 3 3 0 bZIP transcription factor DUF3450 PF11932.3 ERZ98896.1 - 0.1 11.8 0.1 0.1 11.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Cep57_CLD_2 PF14197.1 ERZ98896.1 - 0.31 11.0 7.3 0.13 12.1 2.5 2.5 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF972 PF06156.8 ERZ98896.1 - 0.33 11.2 6.0 0.05 13.9 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Elongin_A PF06881.6 ERZ98896.1 - 1.1 9.6 6.7 2 8.7 4.6 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A HMG_box PF00505.14 ERZ98898.1 - 2.2e-06 27.8 0.2 3.6e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ98898.1 - 1.2e-05 25.5 0.2 1.7e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain Androgen_recep PF02166.11 ERZ98898.1 - 0.03 13.1 0.0 0.038 12.8 0.0 1.2 1 0 0 1 1 1 0 Androgen receptor Piwi PF02171.12 ERZ98901.1 - 4.1e-35 121.2 0.2 5.4e-35 120.8 0.1 1.0 1 0 0 1 1 1 1 Piwi domain Piwi PF02171.12 ERZ98902.1 - 4.2e-86 288.6 0.4 6.2e-86 288.0 0.3 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ98902.1 - 1.4e-10 40.6 0.6 1.4e-10 40.6 0.4 2.3 3 0 0 3 3 3 1 PAZ domain DUF1785 PF08699.5 ERZ98902.1 - 5.8e-10 38.3 0.0 1.5e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Ribosomal_L23 PF00276.15 ERZ98902.1 - 0.1 12.5 1.7 19 5.2 0.0 3.1 3 0 0 3 3 3 0 Ribosomal protein L23 Glyco_hydro_46 PF01374.13 ERZ98903.1 - 0.34 10.4 4.8 0.16 11.4 1.1 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 46 BTB PF00651.26 ERZ98904.1 - 2.7e-19 69.1 0.1 4.5e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ98904.1 - 2.5e-08 33.6 0.9 2.5e-06 27.2 0.0 3.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ98904.1 - 0.021 13.9 0.2 0.04 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Astro_capsid PF03115.9 ERZ98904.1 - 0.062 11.5 0.6 0.098 10.8 0.4 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor BTB PF00651.26 ERZ98905.1 - 5.6e-12 45.6 0.1 2.4e-11 43.5 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ98905.1 - 1.3e-09 38.2 2.2 2.4e-09 37.2 1.5 1.4 1 0 0 1 1 1 1 TLD DUF2451 PF10474.4 ERZ98905.1 - 0.035 13.8 0.8 0.06 13.0 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) DUF3342 PF11822.3 ERZ98905.1 - 0.1 11.7 0.3 0.25 10.4 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3342) BACK PF07707.10 ERZ98905.1 - 0.31 10.8 6.8 0.35 10.7 1.4 3.1 3 1 0 3 3 3 0 BTB And C-terminal Kelch tRNA-synt_1c PF00749.16 ERZ98907.1 - 1.6e-109 365.4 0.0 2e-109 365.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ERZ98907.1 - 5e-33 114.2 0.1 1.3e-32 112.8 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.10 ERZ98907.1 - 0.0077 16.9 0.1 0.015 16.0 0.1 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Ribosomal_L4 PF00573.17 ERZ98908.1 - 2.4e-56 190.1 0.2 3e-56 189.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family ABC_tran PF00005.22 ERZ98910.1 - 1.6e-48 164.4 0.1 2.4e-23 82.9 0.0 2.9 2 0 0 2 2 2 2 ABC transporter ABC_tran_2 PF12848.2 ERZ98910.1 - 9.9e-21 73.3 3.9 9.9e-21 73.3 2.7 2.3 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 ERZ98910.1 - 2.6e-16 60.4 7.8 9.7e-05 22.4 0.0 5.0 4 1 1 5 5 5 4 AAA domain SMC_N PF02463.14 ERZ98910.1 - 4.4e-12 45.7 0.2 0.013 14.7 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 ERZ98910.1 - 5.9e-09 36.7 0.7 0.0038 18.0 0.0 4.0 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.1 ERZ98910.1 - 1.1e-07 32.0 0.4 0.009 16.0 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 ERZ98910.1 - 3.2e-07 29.7 0.6 0.0018 17.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 ERZ98910.1 - 3.9e-06 26.7 0.0 0.11 12.4 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_10 PF12846.2 ERZ98910.1 - 4.7e-06 26.2 0.1 0.079 12.3 0.1 2.7 3 0 0 3 3 2 2 AAA-like domain NACHT PF05729.7 ERZ98910.1 - 5.4e-06 26.1 0.0 0.036 13.7 0.0 2.7 2 0 0 2 2 2 2 NACHT domain MobB PF03205.9 ERZ98910.1 - 1.5e-05 24.7 0.4 0.038 13.7 0.0 3.1 3 0 0 3 3 3 2 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 ERZ98910.1 - 1.7e-05 24.0 0.2 0.2 10.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 ERZ98910.1 - 2.4e-05 24.4 0.9 0.15 12.2 0.2 3.5 2 2 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 ERZ98910.1 - 4.9e-05 23.1 0.3 0.094 12.6 0.2 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 ERZ98910.1 - 5.3e-05 23.6 19.2 0.0062 16.8 0.0 4.9 5 0 0 5 5 5 2 AAA domain AAA_33 PF13671.1 ERZ98910.1 - 6e-05 22.9 0.4 0.18 11.6 0.0 3.4 3 0 0 3 3 3 1 AAA domain Miro PF08477.8 ERZ98910.1 - 0.00016 22.1 0.0 0.66 10.4 0.0 2.6 2 0 0 2 2 2 2 Miro-like protein AAA_28 PF13521.1 ERZ98910.1 - 0.00021 21.2 0.3 0.26 11.2 0.0 2.8 3 0 0 3 3 2 1 AAA domain T2SE PF00437.15 ERZ98910.1 - 0.00056 18.8 0.0 0.0061 15.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.1 ERZ98910.1 - 0.0015 18.4 0.2 3 7.7 0.0 3.2 3 0 0 3 3 2 1 AAA domain NB-ARC PF00931.17 ERZ98910.1 - 0.0016 17.3 0.0 0.19 10.5 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.24 ERZ98910.1 - 0.0025 18.0 0.0 3.2 7.9 0.0 3.0 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ98910.1 - 0.0031 17.2 0.1 3.2 7.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 ERZ98910.1 - 0.0031 17.1 0.0 0.15 11.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ERZ98910.1 - 0.0036 17.4 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.1 ERZ98910.1 - 0.0039 17.4 11.8 0.17 12.2 0.0 4.7 5 3 1 6 6 5 2 AAA domain DUF2813 PF11398.3 ERZ98910.1 - 0.0045 16.1 3.4 0.3 10.1 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2813) cobW PF02492.14 ERZ98910.1 - 0.01 15.3 0.2 5.1 6.5 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 ERZ98910.1 - 0.012 15.4 7.5 0.43 10.3 0.1 3.6 3 1 1 4 4 3 0 Dynamin family ArgK PF03308.11 ERZ98910.1 - 0.013 14.3 0.2 4.9 5.8 0.0 2.7 2 0 0 2 2 2 0 ArgK protein AAA_25 PF13481.1 ERZ98910.1 - 0.013 14.9 0.0 5.6 6.3 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.1 ERZ98910.1 - 0.017 14.6 0.0 6 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ERZ98910.1 - 0.025 14.2 0.3 6.8 6.3 0.0 2.6 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.13 ERZ98910.1 - 0.026 13.9 0.1 2.4 7.5 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 ERZ98910.1 - 0.044 13.2 0.0 12 5.3 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 ERZ98910.1 - 0.084 12.3 0.1 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Arch_ATPase PF01637.13 ERZ98910.1 - 0.24 11.0 6.3 4.9 6.7 0.0 3.3 4 0 0 4 4 3 0 Archaeal ATPase DUF87 PF01935.12 ERZ98910.1 - 0.29 10.8 0.0 0.29 10.8 0.0 4.4 5 1 1 6 6 5 0 Domain of unknown function DUF87 AAA_15 PF13175.1 ERZ98910.1 - 0.46 9.4 21.5 1.8 7.5 0.0 5.1 5 1 0 5 5 5 0 AAA ATPase domain LSM PF01423.17 ERZ98911.1 - 6e-15 54.5 0.0 7.2e-15 54.2 0.0 1.1 1 0 0 1 1 1 1 LSM domain PSII_Ycf12 PF05969.6 ERZ98911.1 - 0.065 12.8 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Photosystem II complex subunit Ycf12 Tim17 PF02466.14 ERZ98912.1 - 0.067 13.2 1.2 0.23 11.5 0.5 2.0 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Arylesterase PF01731.15 ERZ98913.1 - 2.4e-12 46.6 0.2 5.3e-12 45.5 0.1 1.6 1 0 0 1 1 1 1 Arylesterase SGL PF08450.7 ERZ98913.1 - 1.1e-06 28.2 0.0 1.7e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region DUF3829 PF12889.2 ERZ98914.1 - 0.55 9.3 6.3 0.83 8.7 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Ras PF00071.17 ERZ98916.1 - 3.1e-43 146.9 0.0 3.9e-43 146.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ98916.1 - 5.4e-14 52.7 0.0 7.5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ERZ98916.1 - 0.0054 16.6 0.0 0.0069 16.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 ERZ98916.1 - 0.011 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Suc_Fer-like PF06999.7 ERZ98917.1 - 4.4e-51 174.1 1.0 3.2e-50 171.2 0.0 2.0 2 0 0 2 2 2 1 Sucrase/ferredoxin-like Macoilin PF09726.4 ERZ98918.1 - 3.1 5.9 12.1 3.4 5.8 8.4 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF3827 PF12877.2 ERZ98918.1 - 5.2 5.0 8.5 4.4 5.2 5.5 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) Fmp27 PF10344.4 ERZ98920.1 - 0.0072 14.0 0.1 0.0079 13.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Xylanase PF13201.1 ERZ98921.1 - 0.24 10.1 1.7 0.28 9.9 1.2 1.0 1 0 0 1 1 1 0 Putative glycoside hydrolase xylanase Pkinase_Tyr PF07714.12 ERZ98922.1 - 6.8e-15 54.8 0.0 9.2e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ98922.1 - 7.1e-14 51.5 0.0 1.3e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Fork_head PF00250.13 ERZ98922.1 - 0.044 13.8 0.2 0.074 13.1 0.1 1.4 1 0 0 1 1 1 0 Fork head domain Kelch_4 PF13418.1 ERZ98923.1 - 5e-12 45.3 8.4 9.7e-05 22.0 0.0 5.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ERZ98923.1 - 2.9e-11 43.0 10.7 3e-05 23.8 0.0 5.2 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.1 ERZ98923.1 - 1.4e-09 37.8 12.6 0.059 13.5 0.1 6.0 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ERZ98923.1 - 5.3e-08 32.3 1.4 0.0013 18.4 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ERZ98923.1 - 1.1e-07 31.7 11.8 0.057 13.6 0.0 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ERZ98923.1 - 1e-06 28.1 11.4 0.027 14.0 0.2 5.1 5 0 0 5 5 5 4 Kelch motif SBF2 PF12335.3 ERZ98924.1 - 1.1 8.5 6.2 0.16 11.3 0.6 2.2 2 0 0 2 2 2 0 Myotubularin protein RNA_pol_Rpb1_5 PF04998.12 ERZ98925.1 - 6.1e-97 324.1 0.2 6.1e-97 324.1 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ERZ98925.1 - 2.1e-59 200.1 0.1 2.1e-59 200.1 0.1 2.8 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 ERZ98925.1 - 1.1e-32 112.9 0.0 4.2e-32 111.0 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ERZ98925.1 - 1.3e-24 85.9 0.1 1.1e-23 82.9 0.1 2.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 ERZ98925.1 - 4.4e-24 85.3 27.4 2.1e-22 79.8 10.3 4.4 3 1 0 3 3 3 1 RNA polymerase Rpb1, domain 1 Bac_DnaA PF00308.13 ERZ98926.1 - 0.003 17.2 0.0 0.0037 16.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial dnaA protein Arch_ATPase PF01637.13 ERZ98926.1 - 0.088 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase YcgR PF07317.7 ERZ98927.1 - 0.047 13.4 0.1 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 Flagellar regulator YcgR Ricin_B_lectin PF00652.17 ERZ98928.1 - 0.0062 16.5 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF4379 PF14311.1 ERZ98928.1 - 0.037 13.8 1.0 0.079 12.7 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) zf-RVT PF13966.1 ERZ98931.1 - 0.0071 16.6 1.0 0.023 14.9 0.7 1.9 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-Sec23_Sec24 PF04810.10 ERZ98931.1 - 0.024 14.1 0.1 0.077 12.5 0.1 1.9 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Swi5 PF07061.6 ERZ98932.1 - 2.8e-06 26.9 9.5 0.065 13.0 0.2 3.6 3 0 0 3 3 3 3 Swi5 Fer4_7 PF12838.2 ERZ98932.1 - 0.00016 21.9 0.0 4.1 7.8 0.0 4.0 3 1 1 4 4 4 1 4Fe-4S dicluster domain DNA_pol3_beta PF00712.14 ERZ98932.1 - 0.00035 20.4 1.5 7.6 6.4 0.0 3.5 3 0 0 3 3 3 2 DNA polymerase III beta subunit, N-terminal domain DUF2535 PF10751.4 ERZ98932.1 - 0.005 16.9 8.8 1.6 8.9 0.2 3.9 4 0 0 4 4 4 2 Protein of unknown function (DUF2535) DUF4134 PF13572.1 ERZ98932.1 - 0.036 14.1 1.8 27 4.9 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4134) DUF2789 PF10982.3 ERZ98932.1 - 0.054 13.5 8.0 13 5.9 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2789) DUF72 PF01904.13 ERZ98932.1 - 5.4 6.7 6.9 13 5.4 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function DUF72 zf-4CXXC_R1 PF10497.4 ERZ98933.1 - 0.04 14.0 1.1 3.8 7.7 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DUF2789 PF10982.3 ERZ98934.1 - 0.0041 17.1 3.5 0.28 11.2 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2789) UBA PF00627.26 ERZ98934.1 - 0.07 13.0 0.0 3 7.8 0.0 2.6 2 0 0 2 2 2 0 UBA/TS-N domain BBS2_Mid PF14783.1 ERZ98934.1 - 0.93 9.2 4.2 1 9.1 0.1 2.2 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Fer4_16 PF13484.1 ERZ98934.1 - 1.2 9.9 9.5 4.9 7.9 0.7 3.1 2 2 0 2 2 2 0 4Fe-4S double cluster binding domain AAA-ATPase_like PF09820.4 ERZ98935.1 - 0.0093 15.1 0.7 0.019 14.1 0.1 1.7 2 0 0 2 2 2 1 Predicted AAA-ATPase DHC_N2 PF08393.8 ERZ98935.1 - 0.035 12.6 1.4 0.045 12.2 1.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 DUF3836 PF12930.2 ERZ98935.1 - 0.05 13.1 0.1 0.15 11.5 0.0 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF3836) zf-C4H2 PF10146.4 ERZ98935.1 - 0.085 12.8 0.1 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein DUF924 PF06041.6 ERZ98935.1 - 0.1 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) Phage_int_SAM_5 PF13102.1 ERZ98935.1 - 0.18 11.8 2.5 0.45 10.5 0.1 2.1 2 0 0 2 2 2 0 Phage integrase SAM-like domain Piwi PF02171.12 ERZ98936.1 - 6e-91 304.5 0.3 8.5e-91 304.0 0.2 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ98936.1 - 5.5e-16 58.0 2.6 6.6e-16 57.8 0.6 1.9 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ERZ98936.1 - 1.5e-13 49.8 0.0 4.4e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Piwi PF02171.12 ERZ98937.1 - 2.6e-97 325.4 0.0 3.2e-97 325.1 0.0 1.1 1 0 0 1 1 1 1 Piwi domain Piwi PF02171.12 ERZ98938.1 - 4.4e-99 331.2 0.0 9.6e-99 330.1 0.0 1.5 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.17 ERZ98938.1 - 7.1e-21 73.9 0.9 7.1e-21 73.9 0.6 1.8 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ERZ98938.1 - 3.9e-15 54.9 0.0 9.5e-15 53.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Piwi PF02171.12 ERZ98939.1 - 1.9e-51 174.8 0.1 2.3e-51 174.5 0.1 1.0 1 0 0 1 1 1 1 Piwi domain TFIID-31kDa PF02291.10 ERZ98940.1 - 0.1 12.3 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Nol1_Nop2_Fmu PF01189.12 ERZ98941.1 - 2.3e-101 338.8 0.0 2.7e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 NOL1/NOP2/sun family Met_10 PF02475.11 ERZ98941.1 - 4.4e-05 23.1 0.0 7.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.1 ERZ98941.1 - 0.0018 17.8 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.7 ERZ98941.1 - 0.027 14.0 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) FtsJ PF01728.14 ERZ98941.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Evr1_Alr PF04777.8 ERZ98942.1 - 1.7e-30 104.7 1.1 1.7e-30 104.7 0.8 2.2 2 1 0 2 2 2 1 Erv1 / Alr family Cut8_C PF08559.5 ERZ98942.1 - 0.019 14.7 0.5 0.031 14.0 0.1 1.5 1 1 0 1 1 1 0 Cut8 six-helix bundle Ima1_N PF09779.4 ERZ98942.1 - 2 8.9 12.1 0.43 11.0 3.6 2.7 1 1 2 3 3 3 0 Ima1 N-terminal domain HEAT_EZ PF13513.1 ERZ98943.1 - 5.1e-31 106.3 16.0 6.6e-10 39.1 0.0 11.2 11 3 1 12 12 11 7 HEAT-like repeat HEAT PF02985.17 ERZ98943.1 - 3.9e-27 91.8 24.6 0.001 18.9 0.0 11.7 14 0 0 14 14 13 7 HEAT repeat HEAT_2 PF13646.1 ERZ98943.1 - 2e-25 88.8 0.7 1.9e-05 24.8 0.0 7.2 5 2 3 8 8 8 6 HEAT repeats Arm PF00514.18 ERZ98943.1 - 2e-13 49.6 8.3 0.0014 18.4 0.0 8.6 9 0 0 9 9 8 3 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.2 ERZ98943.1 - 2.4e-13 50.2 0.6 0.014 15.7 0.2 6.5 5 1 1 6 6 6 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 ERZ98943.1 - 7.9e-08 32.1 1.6 2.9e-07 30.3 0.0 3.0 4 0 0 4 4 4 1 Importin-beta N-terminal domain Adaptin_N PF01602.15 ERZ98943.1 - 1.2e-05 23.8 1.1 0.13 10.5 0.3 4.2 3 2 0 4 4 4 2 Adaptin N terminal region Cnd1 PF12717.2 ERZ98943.1 - 3.6e-05 23.6 2.5 2 8.2 0.2 4.9 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.2 ERZ98943.1 - 0.0045 16.9 3.0 3 7.9 0.0 4.8 6 0 0 6 6 6 1 HEAT repeat associated with sister chromatid cohesion DUF1981 PF09324.5 ERZ98943.1 - 0.015 14.7 0.1 1.6 8.2 0.0 3.2 4 0 0 4 4 3 0 Domain of unknown function (DUF1981) UNC45-central PF11701.3 ERZ98943.1 - 0.072 12.7 2.6 3.4 7.3 0.2 3.6 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central HflK_N PF12221.3 ERZ98943.1 - 0.097 12.4 0.0 0.32 10.7 0.0 1.9 1 0 0 1 1 1 0 Bacterial membrane protein N terminal DUF2435 PF10363.4 ERZ98943.1 - 0.25 11.2 2.4 0.45 10.4 0.1 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2435) HEAT_PBS PF03130.11 ERZ98943.1 - 3.8 8.2 6.2 74 4.2 0.0 5.6 6 0 0 6 6 5 0 PBS lyase HEAT-like repeat Oxidored-like PF09791.4 ERZ98944.1 - 2.6e-18 65.1 1.1 4.9e-18 64.3 0.8 1.5 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Utp21 PF04192.7 ERZ98946.1 - 0.096 11.7 0.2 0.14 11.2 0.2 1.3 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain DUF1374 PF07118.6 ERZ98950.1 - 0.092 12.8 0.3 0.17 12.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) DUF4298 PF14131.1 ERZ98950.1 - 0.095 12.5 0.2 0.17 11.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4298) DASH_Dad1 PF08649.5 ERZ98950.1 - 0.82 9.4 3.3 22 4.8 0.1 2.5 2 1 0 2 2 2 0 DASH complex subunit Dad1 LRR_6 PF13516.1 ERZ98950.1 - 2.9 8.2 11.1 6 7.2 1.0 4.5 3 2 0 3 3 3 0 Leucine Rich repeat LRR_4 PF12799.2 ERZ98950.1 - 5 6.8 11.9 4.5 7.0 1.8 3.7 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) RNase_H PF00075.19 ERZ98951.1 - 6.9e-06 26.4 0.1 1.5e-05 25.3 0.1 1.5 1 1 0 1 1 1 1 RNase H AAA PF00004.24 ERZ98953.1 - 3.1e-42 143.8 0.0 3.4e-40 137.3 0.0 3.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ERZ98953.1 - 5.6e-05 23.9 1.0 0.00027 21.7 0.2 2.6 2 1 0 2 2 1 1 AAA domain AAA_10 PF12846.2 ERZ98953.1 - 6.1e-05 22.6 0.4 0.03 13.7 0.0 2.5 1 1 1 2 2 2 2 AAA-like domain AAA_16 PF13191.1 ERZ98953.1 - 0.00045 20.2 0.2 0.067 13.1 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 ERZ98953.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ERZ98953.1 - 0.00056 19.0 0.0 0.0013 17.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 ERZ98953.1 - 0.00064 19.8 0.1 0.0053 16.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ERZ98953.1 - 0.00084 18.1 0.0 0.0016 17.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 ERZ98953.1 - 0.0012 18.5 0.2 0.0088 15.7 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ERZ98953.1 - 0.0016 18.7 0.5 0.0088 16.3 0.0 2.6 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.12 ERZ98953.1 - 0.0021 17.5 0.1 0.0066 15.8 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.1 ERZ98953.1 - 0.0038 16.9 0.2 0.036 13.8 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain Mg_chelatase PF01078.16 ERZ98953.1 - 0.0045 16.1 0.6 0.011 14.9 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ERZ98953.1 - 0.0053 16.6 0.0 0.031 14.1 0.0 2.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ERZ98953.1 - 0.0058 16.2 0.8 0.078 12.5 0.0 2.9 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.1 ERZ98953.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ERZ98953.1 - 0.014 15.5 0.1 0.066 13.3 0.0 2.2 2 0 0 2 2 1 0 RNA helicase Zeta_toxin PF06414.7 ERZ98953.1 - 0.016 14.3 0.2 0.18 10.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin IPT PF01745.11 ERZ98953.1 - 0.018 14.2 0.0 0.083 12.0 0.0 1.9 2 0 0 2 2 2 0 Isopentenyl transferase Sigma54_activ_2 PF14532.1 ERZ98953.1 - 0.018 15.0 0.0 0.088 12.8 0.0 2.2 2 0 0 2 2 1 0 Sigma-54 interaction domain ATP-synt_ab PF00006.20 ERZ98953.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 ERZ98953.1 - 0.068 12.7 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ERZ98953.1 - 0.12 11.5 0.0 0.29 10.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein PELOTA_1 PF15608.1 ERZ98953.1 - 0.13 12.0 0.6 0.42 10.4 0.4 1.8 1 0 0 1 1 1 0 PELOTA RNA binding domain AAA_25 PF13481.1 ERZ98953.1 - 0.16 11.3 4.2 0.43 9.9 0.2 2.6 2 1 0 3 3 2 0 AAA domain Amidoligase_2 PF12224.3 ERZ98954.1 - 0.037 13.6 1.9 0.11 12.0 0.1 2.2 1 1 1 2 2 2 0 Putative amidoligase enzyme Phage_hub_GP28 PF11110.3 ERZ98954.1 - 0.074 12.7 1.2 2.4 7.8 0.1 2.6 2 0 0 2 2 2 0 Baseplate hub distal subunit HNH PF01844.18 ERZ98954.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 HNH endonuclease Uma2 PF05685.7 ERZ98956.1 - 2.6e-06 26.9 0.0 4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease End3 PF12761.2 ERZ98956.1 - 0.25 10.9 4.4 0.38 10.3 3.0 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 NatB_MDM20 PF09797.4 ERZ98957.1 - 0.0068 15.1 0.5 0.0072 15.0 0.4 1.0 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit UvdE PF03851.9 ERZ98957.1 - 0.034 13.1 0.1 0.037 13.0 0.0 1.0 1 0 0 1 1 1 0 UV-endonuclease UvdE DUF3919 PF13057.1 ERZ98957.1 - 0.054 12.9 1.4 0.056 12.9 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) Intron_maturas2 PF01348.16 ERZ98957.1 - 0.083 12.8 2.9 0.88 9.5 0.8 2.1 1 1 1 2 2 2 0 Type II intron maturase ZYG-11_interact PF05884.7 ERZ98957.1 - 0.086 11.9 0.1 0.093 11.8 0.1 1.0 1 0 0 1 1 1 0 Interactor of ZYG-11 Glyco_hydro_8 PF01270.12 ERZ98960.1 - 0.029 13.1 0.5 0.036 12.7 0.3 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 8 p450 PF00067.17 ERZ98961.1 - 3.2e-73 246.8 0.0 4.8e-73 246.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 CtIP_N PF10482.4 ERZ98961.1 - 0.16 11.7 1.2 0.27 11.0 0.8 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain HARE-HTH PF05066.8 ERZ98962.1 - 1.5e-07 31.6 0.0 3.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain Ank_2 PF12796.2 ERZ98963.1 - 1.1e-16 60.9 0.8 1.8e-07 31.4 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ERZ98963.1 - 4.8e-12 46.0 2.6 1.1e-05 25.7 0.1 3.3 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.25 ERZ98963.1 - 7.8e-11 41.2 2.0 0.00045 19.8 0.2 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 ERZ98963.1 - 3.6e-10 39.0 0.4 0.0058 16.7 0.1 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 ERZ98963.1 - 2e-09 37.4 0.5 0.0013 18.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.8 ERZ98963.1 - 3.6e-05 23.3 0.3 0.00031 20.3 0.2 2.4 1 1 0 1 1 1 1 KilA-N domain Fcf1 PF04900.7 ERZ98964.1 - 2.6e-41 139.7 1.2 2.6e-41 139.7 0.8 1.9 2 0 0 2 2 2 1 Fcf1 ARF7EP_C PF14949.1 ERZ98964.1 - 0.11 12.9 2.2 0.88 10.0 0.0 2.4 2 0 0 2 2 2 0 ARF7 effector protein C-terminus RseC_MucC PF04246.7 ERZ98967.1 - 0.21 11.1 1.3 0.26 10.8 0.9 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Arteri_Gl PF00951.13 ERZ98967.1 - 6.2 6.3 6.9 6.5 6.3 4.8 1.1 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein Maelstrom PF13017.1 ERZ98969.1 - 0.071 12.5 1.2 0.083 12.3 0.8 1.0 1 0 0 1 1 1 0 piRNA pathway germ-plasm component zf-C3HC4_2 PF13923.1 ERZ98970.1 - 0.00029 20.8 11.6 0.00049 20.0 8.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ98970.1 - 0.0032 17.0 10.1 0.0053 16.4 7.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ERZ98970.1 - 0.018 14.8 10.6 0.033 14.0 7.4 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 ERZ98970.1 - 0.048 13.4 12.0 0.081 12.6 8.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DUF1497 PF07384.6 ERZ98970.1 - 0.053 13.6 0.1 0.91 9.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1497) zf-C3HC4 PF00097.20 ERZ98970.1 - 0.065 12.9 12.3 0.11 12.1 8.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ERZ98970.1 - 0.22 11.6 7.7 0.46 10.6 5.4 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger PHD PF00628.24 ERZ98970.1 - 2.8 7.7 9.9 5.5 6.7 6.9 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 ERZ98970.1 - 4.7 7.1 8.7 12 5.9 6.0 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF2540 PF10802.3 ERZ98973.1 - 0.042 13.5 0.1 0.73 9.5 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2540) FAM165 PF14981.1 ERZ98974.1 - 0.014 14.8 1.4 0.02 14.3 0.0 2.0 2 0 0 2 2 2 0 FAM165 family Transposase_21 PF02992.9 ERZ98977.1 - 9.9e-11 41.1 0.0 1.6e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Transposase family tnp2 DUF4218 PF13960.1 ERZ98977.1 - 6.8e-05 22.3 0.1 0.0002 20.8 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) Zn_peptidase_2 PF04298.7 ERZ98980.1 - 0.0015 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase BACON PF13004.2 ERZ98981.1 - 0.11 12.7 2.9 0.6 10.3 0.2 2.7 2 0 0 2 2 2 0 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal HD_assoc PF13286.1 ERZ98983.1 - 7.4e-07 29.3 0.1 0.00011 22.4 0.0 2.2 2 1 0 2 2 2 2 Phosphohydrolase-associated domain KH_1 PF00013.24 ERZ98989.1 - 3.4e-08 32.9 3.4 7.6e-08 31.8 2.4 1.7 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ98989.1 - 1.4e-06 27.7 2.7 4.2e-06 26.2 1.9 1.8 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ERZ98989.1 - 0.0028 17.1 4.4 0.0028 17.1 3.0 2.3 2 0 0 2 2 2 1 KH domain KH_5 PF13184.1 ERZ98989.1 - 0.023 14.4 1.8 0.047 13.4 1.2 1.6 1 0 0 1 1 1 0 NusA-like KH domain KH_4 PF13083.1 ERZ98989.1 - 0.035 13.7 0.5 0.035 13.7 0.4 2.8 2 1 1 3 3 3 0 KH domain Herpes_IE2_3 PF03361.9 ERZ98989.1 - 0.51 9.6 3.8 0.8 9.0 2.7 1.3 1 0 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 RP-C_C PF11800.3 ERZ98989.1 - 0.57 9.8 8.8 0.78 9.4 6.1 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region KH_1 PF00013.24 ERZ98990.1 - 3.8e-07 29.6 2.1 7.1e-07 28.7 1.5 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ERZ98990.1 - 4.1e-05 23.1 0.4 9.5e-05 21.9 0.3 1.7 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ERZ98990.1 - 0.087 12.4 0.9 0.29 10.7 0.0 2.3 2 0 0 2 2 2 0 KH domain DUF3850 PF12961.2 ERZ98990.1 - 0.22 11.4 4.0 0.18 11.7 0.4 2.3 2 1 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3850) Rotamase_2 PF13145.1 ERZ98990.1 - 0.33 11.5 3.9 1.2 9.8 0.3 2.7 2 1 1 3 3 3 0 PPIC-type PPIASE domain zf-CCCH PF00642.19 ERZ98990.1 - 0.35 10.6 4.9 3.3 7.4 0.1 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ERZ98990.1 - 0.42 10.6 7.3 0.85 9.7 5.0 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Cullin PF00888.17 ERZ98992.1 - 9.8e-66 222.5 1.6 1.1e-65 222.3 1.1 1.0 1 0 0 1 1 1 1 Cullin family SAM_PNT PF02198.11 ERZ98995.1 - 0.0048 16.6 0.3 0.015 15.0 0.0 1.9 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SAM_1 PF00536.25 ERZ98995.1 - 0.1 12.7 0.5 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Phage_C PF12025.3 ERZ98995.1 - 0.11 12.4 1.2 0.84 9.6 0.0 2.8 2 0 0 2 2 2 0 Phage protein C Pkinase PF00069.20 ERZ98998.1 - 7.4e-33 113.7 0.0 9.7e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ98998.1 - 3.7e-29 101.5 0.0 4.4e-29 101.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ98998.1 - 0.074 12.0 0.3 0.099 11.6 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ98998.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ERZ98998.1 - 0.17 11.5 0.6 0.27 10.9 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family VID27 PF08553.5 ERZ99000.1 - 0.0015 16.8 0.0 0.0016 16.7 0.0 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein F-box-like PF12937.2 ERZ99004.1 - 0.0042 16.7 1.5 0.019 14.6 0.4 2.3 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 ERZ99005.1 - 0.0014 18.3 4.5 0.19 11.4 0.2 3.7 4 1 0 4 4 4 2 Leucine rich repeat DUF1664 PF07889.7 ERZ99006.1 - 0.026 14.2 0.6 0.026 14.2 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF2951 PF11166.3 ERZ99006.1 - 0.21 11.4 10.1 0.077 12.8 1.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) Pkinase_Tyr PF07714.12 ERZ99007.1 - 0.00067 18.8 0.0 0.00088 18.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase VP7 PF00434.13 ERZ99007.1 - 0.052 12.4 0.4 1.1 8.0 0.0 2.2 1 1 1 2 2 2 0 Glycoprotein VP7 Pkinase_Tyr PF07714.12 ERZ99008.1 - 9.3e-05 21.6 0.1 0.00018 20.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99008.1 - 0.0034 16.5 0.1 0.0082 15.3 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain PDDEXK_2 PF12784.2 ERZ99008.1 - 0.0066 15.6 3.8 0.0088 15.2 2.6 1.1 1 0 0 1 1 1 1 PD-(D/E)XK nuclease family transposase DnaB_2 PF07261.6 ERZ99008.1 - 0.02 14.5 1.5 0.027 14.0 0.1 1.9 2 0 0 2 2 2 0 Replication initiation and membrane attachment DUF2335 PF10097.4 ERZ99008.1 - 0.023 14.3 0.9 0.046 13.3 0.6 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2335) Receptor_2B4 PF11465.3 ERZ99008.1 - 0.045 13.6 1.5 0.07 13.0 0.6 1.7 1 1 0 1 1 1 0 Natural killer cell receptor 2B4 NAS PF03059.11 ERZ99008.1 - 0.21 10.6 1.9 0.3 10.1 1.2 1.3 1 1 0 1 1 1 0 Nicotianamine synthase protein Feld-I_B PF09252.5 ERZ99009.1 - 0.42 10.5 0.1 0.42 10.5 0.0 3.5 3 0 0 3 3 3 0 Allergen Fel d I-B chain RAI1 PF08652.6 ERZ99010.1 - 0.0074 16.0 0.1 0.014 15.1 0.0 1.4 1 1 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease GreA_GreB_N PF03449.10 ERZ99010.1 - 0.05 13.6 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Gon7 PF08738.5 ERZ99011.1 - 0.0015 18.4 8.3 4.8 7.2 0.1 4.5 4 0 0 4 4 4 3 Gon7 family DUF3753 PF12575.3 ERZ99011.1 - 0.29 10.9 7.1 8.3 6.2 0.1 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) DUF693 PF05113.8 ERZ99012.1 - 0.054 12.4 0.6 0.053 12.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF693) Peroxin-22 PF12827.2 ERZ99012.1 - 0.19 11.4 2.0 0.25 11.0 1.3 1.3 1 1 0 1 1 1 0 Peroxisomal biogenesis protein family GST_C PF00043.20 ERZ99014.1 - 6.3e-13 48.5 0.0 8.8e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ERZ99014.1 - 2.2e-07 30.6 0.0 2.8e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ERZ99014.1 - 0.00017 21.7 0.0 0.00036 20.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ERZ99014.1 - 0.00046 20.3 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MetRS-N PF09635.5 ERZ99014.1 - 0.049 14.0 0.0 0.087 13.2 0.0 1.5 1 0 0 1 1 1 0 MetRS-N binding domain GST_N_2 PF13409.1 ERZ99014.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain 7TMR-DISM_7TM PF07695.6 ERZ99016.1 - 2.6 7.6 5.7 0.41 10.3 1.0 1.7 2 0 0 2 2 2 0 7TM diverse intracellular signalling E1_dh PF00676.15 ERZ99017.1 - 1.3e-94 316.3 0.0 1.5e-94 316.0 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.16 ERZ99017.1 - 3.6e-05 22.7 0.0 6.7e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.1 ERZ99017.1 - 0.0016 17.4 0.0 0.0077 15.1 0.0 1.9 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 ERZ99017.1 - 0.0028 17.2 0.2 0.02 14.4 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Carboxyl_trans PF01039.17 ERZ99018.1 - 6.6e-173 575.5 0.1 8.3e-173 575.2 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 ERZ99018.1 - 0.0044 16.2 0.0 0.014 14.6 0.0 1.7 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) Vps54 PF07928.7 ERZ99019.1 - 6.5e-51 172.0 0.2 2.1e-50 170.3 0.1 2.0 1 0 0 1 1 1 1 Vps54-like protein DUF2450 PF10475.4 ERZ99019.1 - 2.5e-11 43.0 0.1 6.8e-11 41.5 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 ERZ99019.1 - 2.7e-05 24.0 0.3 0.00011 22.0 0.2 2.1 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Turandot PF07240.6 ERZ99019.1 - 0.025 14.0 0.7 9.5 5.7 0.0 3.3 2 1 1 3 3 3 0 Stress-inducible humoral factor Turandot Tubulin-binding PF00418.14 ERZ99020.1 - 2.9e-38 129.2 9.0 2.3e-10 39.9 0.0 4.7 5 0 0 5 5 5 4 Tau and MAP protein, tubulin-binding repeat Med9 PF07544.8 ERZ99020.1 - 0.021 14.5 0.0 9.8 6.0 0.0 3.1 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 2OG-FeII_Oxy_3 PF13640.1 ERZ99020.1 - 0.04 14.4 0.0 6.3 7.3 0.0 2.1 1 1 1 2 2 2 0 2OG-Fe(II) oxygenase superfamily Lon_C PF05362.8 ERZ99020.1 - 0.059 12.6 0.0 1.4 8.1 0.0 2.6 1 1 1 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain 2OG-FeII_Oxy_5 PF13759.1 ERZ99020.1 - 0.067 13.4 0.0 3.1 8.1 0.0 2.5 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase DUF1626 PF07788.6 ERZ99020.1 - 0.12 12.2 0.3 3 7.7 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1626) Tubulin-binding PF00418.14 ERZ99021.1 - 1.6e-27 94.8 10.0 1.7e-09 37.2 0.1 3.5 3 0 0 3 3 3 3 Tau and MAP protein, tubulin-binding repeat Med9 PF07544.8 ERZ99021.1 - 0.0018 17.9 0.2 0.25 11.1 0.2 2.8 1 1 1 2 2 2 2 RNA polymerase II transcription mediator complex subunit 9 TFIIA PF03153.8 ERZ99021.1 - 6.8 6.4 16.7 8.8 6.1 11.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MS_channel PF00924.13 ERZ99022.1 - 7.4e-25 87.4 0.1 1.3e-24 86.6 0.1 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF3410 PF11890.3 ERZ99023.1 - 0.22 11.1 3.1 0.23 11.1 1.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3410) Daxx PF03344.10 ERZ99023.1 - 6.5 5.1 26.4 8.4 4.7 18.3 1.1 1 0 0 1 1 1 0 Daxx Family DUF572 PF04502.8 ERZ99023.1 - 7.7 5.6 24.2 10 5.2 16.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Neugrin PF06413.6 ERZ99024.1 - 3.3e-11 43.4 3.6 3.3e-11 43.4 2.5 2.3 2 1 0 2 2 2 1 Neugrin MRP-L20 PF12824.2 ERZ99024.1 - 0.00085 19.3 10.6 0.00085 19.3 7.4 2.5 1 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 FAM183 PF14886.1 ERZ99024.1 - 0.014 15.9 6.8 0.014 15.9 4.7 2.8 2 1 1 3 3 3 0 FAM183A and FAM183B related Phytochelatin PF05023.9 ERZ99024.1 - 0.023 13.6 0.6 0.046 12.6 0.4 1.5 1 0 0 1 1 1 0 Phytochelatin synthase HN PF00423.14 ERZ99024.1 - 0.045 12.0 2.9 0.067 11.4 2.0 1.2 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase HTH_17 PF12728.2 ERZ99024.1 - 0.052 13.7 0.6 0.15 12.2 0.4 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain ubiquitin PF00240.18 ERZ99025.1 - 1.3e-21 75.6 0.3 1.6e-21 75.4 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ERZ99025.1 - 1.2e-12 47.2 0.6 1.3e-12 47.1 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ERZ99025.1 - 3.7e-08 33.4 0.1 4.1e-08 33.3 0.0 1.0 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 ERZ99025.1 - 0.00011 22.3 0.3 0.0003 20.9 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ERZ99025.1 - 0.00012 21.9 0.1 0.00017 21.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.5 ERZ99025.1 - 0.013 16.0 0.0 0.021 15.3 0.0 1.4 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Pkinase PF00069.20 ERZ99026.1 - 2.9e-06 26.6 0.2 1.7e-05 24.1 0.0 2.2 1 1 1 2 2 2 1 Protein kinase domain Kdo PF06293.9 ERZ99026.1 - 0.0016 17.5 0.0 0.0031 16.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ResIII PF04851.10 ERZ99028.1 - 7.9e-22 77.9 0.0 1.8e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ERZ99028.1 - 5.8e-14 51.7 0.0 1.7e-13 50.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ERZ99028.1 - 9.6e-13 47.9 0.0 2.6e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.18 ERZ99028.1 - 0.0002 20.2 0.0 0.00038 19.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2075 PF09848.4 ERZ99028.1 - 0.0024 16.9 0.0 0.0046 15.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 ERZ99028.1 - 0.013 15.0 0.0 5.8 6.4 0.0 2.5 1 1 1 2 2 2 0 AAA domain Helicase_RecD PF05127.9 ERZ99028.1 - 0.057 13.0 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 Helicase Alginate_lyase PF05426.7 ERZ99029.1 - 5.9e-49 166.8 0.4 1e-48 166.0 0.3 1.4 1 0 0 1 1 1 1 Alginate lyase ApoLp-III PF07464.6 ERZ99030.1 - 0.35 10.8 10.4 1.2 9.1 7.2 2.0 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Lipoprotein_20 PF13942.1 ERZ99030.1 - 4.1 6.8 17.5 0.35 10.3 5.8 2.5 1 1 2 3 3 3 0 YfhG lipoprotein Mit_KHE1 PF10173.4 ERZ99030.1 - 4.7 7.0 7.0 7.4 6.3 4.6 1.5 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TBPIP PF07106.8 ERZ99031.1 - 8.4e-47 158.8 16.7 1e-46 158.5 11.5 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Mnd1 PF03962.10 ERZ99031.1 - 1.1e-07 31.6 13.8 1.6e-07 31.1 9.6 1.2 1 0 0 1 1 1 1 Mnd1 family IncA PF04156.9 ERZ99031.1 - 4.5e-05 23.1 11.0 5.8e-05 22.7 7.6 1.3 1 0 0 1 1 1 1 IncA protein Tropomyosin_1 PF12718.2 ERZ99031.1 - 0.0067 16.2 15.7 0.011 15.6 10.9 1.3 1 0 0 1 1 1 1 Tropomyosin like PilJ PF13675.1 ERZ99031.1 - 0.012 15.9 2.4 0.087 13.1 0.3 2.3 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Atg14 PF10186.4 ERZ99031.1 - 0.016 14.1 10.2 0.021 13.7 7.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phasin PF05597.6 ERZ99031.1 - 0.029 14.1 9.5 0.15 11.8 0.2 2.8 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DivIC PF04977.10 ERZ99031.1 - 0.031 13.7 4.0 0.031 13.7 2.8 2.6 1 1 1 2 2 2 0 Septum formation initiator BLOC1_2 PF10046.4 ERZ99031.1 - 0.049 13.7 10.8 0.62 10.2 1.7 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6 PF04111.7 ERZ99031.1 - 0.081 11.9 12.9 0.11 11.5 8.9 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Reo_sigmaC PF04582.7 ERZ99031.1 - 0.1 11.7 1.1 0.14 11.2 0.4 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Cortex-I_coil PF09304.5 ERZ99031.1 - 0.13 12.3 14.5 0.25 11.4 2.5 2.6 1 1 1 2 2 2 0 Cortexillin I, coiled coil V_ATPase_I PF01496.14 ERZ99031.1 - 0.16 9.8 9.8 0.18 9.6 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Striatin PF08232.7 ERZ99031.1 - 0.16 12.2 10.7 0.28 11.5 7.4 1.4 1 0 0 1 1 1 0 Striatin family ADIP PF11559.3 ERZ99031.1 - 0.16 11.8 14.2 0.3 10.9 9.8 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 ERZ99031.1 - 0.22 11.9 12.1 0.54 10.6 8.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Cob_adeno_trans PF01923.13 ERZ99031.1 - 0.24 11.1 4.4 0.38 10.5 2.1 1.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase FlxA PF14282.1 ERZ99031.1 - 0.37 10.7 9.4 4.8 7.1 6.5 2.2 1 1 0 1 1 1 0 FlxA-like protein SYF2 PF08231.7 ERZ99031.1 - 0.39 10.8 15.5 0.39 10.8 9.8 1.6 2 0 0 2 2 1 0 SYF2 splicing factor DUF3573 PF12097.3 ERZ99031.1 - 0.42 9.1 5.7 0.53 8.8 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF3373 PF11853.3 ERZ99031.1 - 0.46 8.9 4.3 0.53 8.7 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Cep57_MT_bd PF06657.8 ERZ99031.1 - 0.47 10.4 6.7 3.1 7.7 4.7 2.3 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Mto2_bdg PF12808.2 ERZ99031.1 - 0.47 10.6 13.9 2.8 8.0 2.0 3.3 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF3394 PF11874.3 ERZ99031.1 - 0.5 9.8 2.8 0.75 9.3 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3394) CtIP_N PF10482.4 ERZ99031.1 - 0.54 10.0 17.9 0.96 9.2 0.4 2.9 1 1 2 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Prefoldin_2 PF01920.15 ERZ99031.1 - 0.67 9.7 16.3 2.8 7.7 2.6 2.6 1 1 1 2 2 2 0 Prefoldin subunit TMF_TATA_bd PF12325.3 ERZ99031.1 - 0.68 9.6 14.9 0.42 10.3 7.2 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Med9 PF07544.8 ERZ99031.1 - 0.95 9.2 10.3 0.24 11.1 0.7 2.5 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 AAA_32 PF13654.1 ERZ99031.1 - 1 7.9 12.7 1.9 7.0 8.8 1.6 1 1 0 1 1 1 0 AAA domain DUF342 PF03961.8 ERZ99031.1 - 1.1 7.6 13.5 1.2 7.4 8.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) TMF_DNA_bd PF12329.3 ERZ99031.1 - 1.7 8.5 17.6 4.8 7.0 11.2 2.4 2 1 0 2 2 1 0 TATA element modulatory factor 1 DNA binding Uds1 PF15456.1 ERZ99031.1 - 2.3 8.2 10.7 0.12 12.4 1.6 2.3 1 1 1 2 2 2 0 Up-regulated During Septation Prefoldin PF02996.12 ERZ99031.1 - 2.4 7.8 12.3 1.7 8.3 2.3 2.8 1 1 1 2 2 2 0 Prefoldin subunit DUF2935 PF11155.3 ERZ99031.1 - 3 7.9 7.7 3.1 7.9 4.2 2.0 2 1 0 2 2 1 0 Domain of unknown function (DUF2935) DUF4407 PF14362.1 ERZ99031.1 - 3 6.6 6.9 3.9 6.3 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.9 ERZ99031.1 - 3.3 7.6 16.0 20 5.1 10.9 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-H PF05837.7 ERZ99031.1 - 3.7 7.7 16.0 3.8 7.7 7.0 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Cep57_CLD_2 PF14197.1 ERZ99031.1 - 4.9 7.1 13.3 5.1 7.1 3.9 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Seryl_tRNA_N PF02403.17 ERZ99031.1 - 5.1 7.1 18.3 0.62 10.0 7.1 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CorA PF01544.13 ERZ99031.1 - 5.6 5.9 10.7 0.37 9.7 2.3 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein UPF0184 PF03670.8 ERZ99031.1 - 6.1 7.0 8.8 14 5.9 3.8 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) TMPIT PF07851.8 ERZ99031.1 - 7 5.6 11.4 7.8 5.4 7.1 1.5 1 1 1 2 2 2 0 TMPIT-like protein cwf21 PF08312.7 ERZ99031.1 - 7.3 6.5 10.7 9.4 6.1 0.4 2.8 2 1 0 2 2 2 0 cwf21 domain Fib_alpha PF08702.5 ERZ99031.1 - 7.4 6.6 13.5 0.71 9.9 1.5 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family GrpE PF01025.14 ERZ99031.1 - 8.1 5.9 17.3 2.6 7.5 4.3 2.4 1 1 1 2 2 2 0 GrpE DUF904 PF06005.7 ERZ99031.1 - 8.8 6.6 17.2 48 4.3 11.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ERZ99031.1 - 9.9 6.2 22.3 0.43 10.5 2.7 2.8 2 1 1 3 3 2 0 bZIP transcription factor BTB_2 PF02214.17 ERZ99032.1 - 0.00026 21.1 0.0 0.00097 19.2 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.20 ERZ99033.1 - 1e-69 234.5 0.0 2.2e-69 233.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99033.1 - 3.2e-50 170.6 0.0 4.9e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_transf_22 PF03901.12 ERZ99033.1 - 6e-13 48.5 8.5 8.5e-13 48.0 5.9 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Kinase-like PF14531.1 ERZ99033.1 - 2e-05 23.7 0.0 4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF377 PF04041.8 ERZ99033.1 - 0.033 12.9 0.0 0.056 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF377) DUF2101 PF09874.4 ERZ99033.1 - 0.09 12.2 3.8 0.16 11.4 2.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) VIT1 PF01988.14 ERZ99033.1 - 7.7 5.9 6.4 4.3 6.7 0.1 2.5 3 0 0 3 3 3 0 VIT family Mif2_N PF15624.1 ERZ99034.1 - 4.7 7.8 9.0 7.5 7.1 0.1 2.7 3 0 0 3 3 3 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CMAS PF02353.15 ERZ99035.1 - 5.9e-71 238.7 0.1 1.6e-70 237.3 0.1 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 ERZ99035.1 - 5.3e-09 36.6 0.0 1.1e-08 35.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ERZ99035.1 - 3.6e-06 26.7 0.0 1.4e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ERZ99035.1 - 1.2e-05 24.9 0.0 2.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ERZ99035.1 - 0.00011 22.5 0.0 0.00027 21.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 ERZ99035.1 - 0.00051 19.1 0.0 0.00089 18.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.9 ERZ99035.1 - 0.00052 19.4 0.0 0.00083 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ERZ99035.1 - 0.0012 18.9 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ99035.1 - 0.0089 16.4 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ERZ99035.1 - 0.023 14.2 0.0 0.12 11.8 0.0 1.9 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPR_11 PF13414.1 ERZ99036.1 - 2.6e-45 151.9 42.1 2.1e-07 30.4 0.3 14.9 11 4 6 17 17 17 11 TPR repeat TPR_1 PF00515.23 ERZ99036.1 - 4.5e-33 111.5 37.5 2.8e-05 23.5 0.0 15.0 17 0 0 17 17 17 8 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ99036.1 - 6e-30 100.7 44.2 0.00054 19.6 0.0 16.7 17 0 0 17 17 17 9 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ99036.1 - 3.7e-29 98.4 26.8 0.0024 17.9 0.0 15.3 18 0 0 18 18 15 8 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ99036.1 - 1e-25 87.8 7.8 0.077 13.6 0.0 15.0 11 2 5 16 16 15 6 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ99036.1 - 8e-24 83.7 21.7 0.0005 20.6 0.0 10.3 10 2 0 11 11 10 6 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ99036.1 - 2.1e-23 82.0 31.5 4.4e-05 23.3 0.0 10.7 6 2 4 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ99036.1 - 1.7e-18 66.7 21.3 1.7e-06 28.2 0.0 9.7 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ99036.1 - 2.6e-18 64.3 33.4 0.00077 19.0 0.0 14.4 14 1 1 15 15 15 6 Tetratricopeptide repeat Apc3 PF12895.2 ERZ99036.1 - 7.4e-12 45.2 21.3 5.1e-06 26.5 0.3 8.1 8 2 2 10 10 10 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ERZ99036.1 - 1.7e-11 43.7 19.8 1.7 9.2 0.0 11.7 13 0 0 13 13 12 1 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ99036.1 - 4.9e-10 38.4 23.3 1.5 8.8 0.0 12.6 13 1 1 14 14 14 2 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ99036.1 - 3.9e-09 36.2 3.9 0.13 12.1 0.0 6.5 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ99036.1 - 3.3e-05 23.6 9.5 2.7 8.0 0.0 7.5 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_20 PF14561.1 ERZ99036.1 - 0.037 14.1 5.6 6.8 6.8 0.0 5.2 6 1 0 6 6 6 0 Tetratricopeptide repeat DUF2362 PF10154.4 ERZ99037.1 - 0.0045 15.7 1.1 0.0045 15.7 0.7 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) Imm24 PF15570.1 ERZ99037.1 - 0.054 13.2 0.6 0.076 12.7 0.3 1.3 1 1 0 1 1 1 0 Immunity protein 24 Pkinase_Tyr PF07714.12 ERZ99038.1 - 6e-47 159.8 0.0 2.2e-46 158.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99038.1 - 1e-42 146.1 2.4 3.3e-42 144.4 0.5 2.3 2 1 0 2 2 2 1 Protein kinase domain Kelch_2 PF07646.10 ERZ99039.1 - 1.7e-07 30.6 0.3 0.034 13.9 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ERZ99039.1 - 1.1e-05 24.8 0.5 0.0054 16.2 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ERZ99039.1 - 3.6e-05 23.4 5.1 0.0046 16.7 0.0 3.9 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ99039.1 - 7.5e-05 22.7 2.0 0.092 12.9 0.0 3.0 3 0 0 3 3 3 2 Kelch motif DUF615 PF04751.9 ERZ99041.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) Homeobox_KN PF05920.6 ERZ99041.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain F-box-like PF12937.2 ERZ99043.1 - 1.5e-06 27.7 0.3 6.5e-06 25.7 0.1 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ99043.1 - 0.00035 20.1 0.0 0.00083 18.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain Sigma54_CBD PF04963.8 ERZ99043.1 - 0.02 14.3 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain zinc_ribbon_5 PF13719.1 ERZ99043.1 - 0.12 11.9 1.5 0.44 10.1 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain JHBP PF06585.6 ERZ99045.1 - 0.015 14.1 0.5 0.02 13.7 0.4 1.1 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) HMG_box PF00505.14 ERZ99046.1 - 4.6e-09 36.4 0.1 8.5e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99046.1 - 0.0063 16.8 0.1 0.01 16.1 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain Sigma_1s PF02454.11 ERZ99046.1 - 0.017 14.8 0.3 5.2 6.8 0.1 2.2 2 0 0 2 2 2 0 Sigma 1s protein Toxin_52 PF15605.1 ERZ99046.1 - 0.074 12.9 0.2 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Putative toxin 52 Cse1 PF08506.5 ERZ99048.1 - 7e-149 495.3 10.1 7e-149 495.3 7.0 1.7 2 0 0 2 2 2 1 Cse1 CAS_CSE1 PF03378.10 ERZ99048.1 - 2e-147 491.0 8.3 2e-147 491.0 5.8 2.4 3 0 0 3 3 3 1 CAS/CSE protein, C-terminus IBN_N PF03810.14 ERZ99048.1 - 1.1e-13 50.9 1.7 4.4e-13 48.9 0.3 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 ERZ99048.1 - 0.0029 17.5 9.9 0.016 15.1 1.3 5.1 4 2 2 6 6 6 1 Exportin 1-like protein DUF1563 PF07599.6 ERZ99049.1 - 0.045 13.6 1.8 0.058 13.2 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) Rad9 PF04139.8 ERZ99049.1 - 0.07 12.2 1.0 0.069 12.2 0.7 1.0 1 0 0 1 1 1 0 Rad9 Aldedh PF00171.17 ERZ99050.1 - 7.6e-166 552.0 0.1 8.6e-166 551.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 ERZ99050.1 - 0.001 17.9 0.1 0.0017 17.1 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.6 ERZ99050.1 - 0.014 14.6 0.0 0.12 11.6 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) OmdA PF13376.1 ERZ99050.1 - 0.099 12.3 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated RTC PF01137.16 ERZ99051.1 - 9e-58 194.7 0.0 1.7e-57 193.8 0.0 1.4 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 ERZ99051.1 - 1.3e-18 66.8 0.4 2.2e-18 66.1 0.3 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain DUF367 PF04034.8 ERZ99052.1 - 5.1e-55 184.5 0.0 6.7e-55 184.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 ERZ99052.1 - 1.2e-13 50.3 0.1 2.1e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CDC45 PF02724.9 ERZ99052.1 - 0.014 13.4 10.9 0.017 13.2 7.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid PF03115.9 ERZ99052.1 - 0.04 12.2 3.9 0.041 12.1 2.7 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Replicase PF03090.12 ERZ99052.1 - 0.05 13.4 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Replicase family Daxx PF03344.10 ERZ99052.1 - 0.16 10.4 18.6 0.19 10.1 12.9 1.0 1 0 0 1 1 1 0 Daxx Family Rhabdo_ncap PF00945.13 ERZ99052.1 - 0.23 9.9 3.2 0.28 9.7 2.2 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Cwf_Cwc_15 PF04889.7 ERZ99052.1 - 1.8 8.1 21.6 2.4 7.7 15.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.6 ERZ99052.1 - 1.8 8.3 17.0 2.7 7.7 11.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Dicty_REP PF05086.7 ERZ99052.1 - 2.5 5.7 12.9 3.3 5.3 9.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RNA_pol_3_Rpc31 PF11705.3 ERZ99052.1 - 4.6 7.1 24.7 6.5 6.6 17.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 EBV-NA3 PF05009.7 ERZ99052.1 - 8.4 5.5 9.3 19 4.3 6.5 1.5 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) DUF2457 PF10446.4 ERZ99052.1 - 9 4.8 31.9 11 4.6 22.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) HlyIII PF03006.15 ERZ99053.1 - 8.7e-48 162.6 28.7 1.1e-47 162.3 19.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related Enterotoxin_a PF01375.12 ERZ99053.1 - 0.02 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Heat-labile enterotoxin alpha chain SVM_signal PF12113.3 ERZ99053.1 - 0.33 10.8 0.1 0.33 10.8 0.1 2.2 2 0 0 2 2 2 0 SVM protein signal sequence DUF1218 PF06749.7 ERZ99054.1 - 0.014 15.8 1.1 0.79 10.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DUF202 PF02656.10 ERZ99054.1 - 9.8 6.4 11.9 1.1 9.5 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) XendoU PF09412.5 ERZ99055.1 - 1e-79 267.3 0.1 1.2e-79 267.0 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU DUF2778 PF10908.3 ERZ99055.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2778) Anemone_cytotox PF06369.7 ERZ99056.1 - 1.5e-26 92.8 0.3 1.7e-26 92.7 0.2 1.0 1 0 0 1 1 1 1 Sea anemone cytotoxic protein p450 PF00067.17 ERZ99057.1 - 1.5e-50 172.0 0.0 1.7e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.23 ERZ99059.1 - 6.4e-80 268.5 0.0 7.4e-80 268.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SCO1-SenC PF02630.9 ERZ99059.1 - 0.0089 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC HMG_box PF00505.14 ERZ99061.1 - 1.1e-12 47.9 3.7 2.1e-06 27.8 0.1 2.6 2 0 0 2 2 2 2 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ERZ99061.1 - 2.2e-05 23.8 4.1 0.0058 15.9 0.1 2.2 2 0 0 2 2 2 2 Mating-type protein MAT alpha 1 DUF4373 PF14297.1 ERZ99061.1 - 0.0088 16.3 0.1 0.073 13.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4373) HMG_box_2 PF09011.5 ERZ99061.1 - 0.017 15.4 2.4 0.28 11.5 0.2 2.5 2 1 0 2 2 2 0 HMG-box domain Radial_spoke PF04712.7 ERZ99061.1 - 0.026 13.3 0.3 0.026 13.3 0.2 1.8 1 1 1 2 2 2 0 Radial spokehead-like protein FimH_man-bind PF09160.5 ERZ99061.1 - 0.042 13.7 0.0 0.87 9.4 0.0 2.3 2 0 0 2 2 2 0 FimH, mannose binding VitD-bind_III PF09164.5 ERZ99061.1 - 0.4 10.3 2.1 9.8 5.8 0.1 3.4 2 1 2 4 4 4 0 Vitamin D binding protein, domain III MBD PF01429.14 ERZ99062.1 - 0.02 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyl-CpG binding domain Helitron_like_N PF14214.1 ERZ99063.1 - 0.0033 17.1 0.1 0.0072 16.0 0.0 1.6 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus p450 PF00067.17 ERZ99066.1 - 1.6e-28 99.5 0.0 1.8e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_8 PF13855.1 ERZ99067.1 - 0.012 15.3 10.0 0.22 11.3 1.2 3.4 2 2 0 2 2 2 0 Leucine rich repeat DUF960 PF06124.6 ERZ99067.1 - 0.014 15.6 1.8 0.014 15.6 1.3 2.2 2 0 0 2 2 2 0 Staphylococcal protein of unknown function (DUF960) LRR_4 PF12799.2 ERZ99067.1 - 0.016 14.8 18.9 0.2 11.3 0.3 4.9 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ99067.1 - 0.25 11.5 5.3 9.5 6.6 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 ERZ99067.1 - 0.44 10.7 0.1 0.44 10.7 0.0 4.9 6 0 0 6 6 6 0 Leucine Rich repeat LRR_7 PF13504.1 ERZ99067.1 - 0.81 10.1 6.6 3.4 8.2 0.0 4.3 4 0 0 4 4 4 0 Leucine rich repeat F-box-like PF12937.2 ERZ99068.1 - 1.6e-05 24.5 0.1 4.3e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 F-box-like Lycopene_cycl PF05834.7 ERZ99068.1 - 0.17 10.7 0.2 16 4.2 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein LRR_8 PF13855.1 ERZ99069.1 - 0.0026 17.4 9.6 0.069 12.9 1.7 3.7 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 ERZ99069.1 - 0.01 15.4 20.0 0.13 11.9 0.1 5.2 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ99069.1 - 0.13 12.3 5.6 15 6.0 0.1 4.9 3 1 1 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 ERZ99069.1 - 0.62 10.3 14.7 1.6 9.0 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich repeat LRR_7 PF13504.1 ERZ99069.1 - 3.2 8.3 9.8 5.5 7.6 0.0 4.9 5 0 0 5 5 5 0 Leucine rich repeat FlaC_arch PF05377.6 ERZ99071.1 - 0.062 13.1 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF285 PF03382.9 ERZ99071.1 - 0.066 12.7 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Mycoplasma protein of unknown function, DUF285 DnaB_2 PF07261.6 ERZ99072.1 - 0.0044 16.5 0.2 0.012 15.2 0.1 1.8 1 1 0 1 1 1 1 Replication initiation and membrane attachment Nairo_nucleo PF02477.10 ERZ99072.1 - 0.075 11.7 0.1 0.078 11.6 0.1 1.2 1 0 0 1 1 1 0 Nucleocapsid N protein ApoC-I PF04691.7 ERZ99073.1 - 0.024 14.3 0.3 0.42 10.3 0.1 3.0 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Syntaxin_2 PF14523.1 ERZ99073.1 - 5 7.2 13.7 9.7 6.2 2.3 3.8 3 1 1 4 4 4 0 Syntaxin-like protein XLF PF09302.6 ERZ99074.1 - 0.011 15.4 0.1 0.02 14.6 0.1 1.8 1 1 0 1 1 1 0 XLF (XRCC4-like factor) p450 PF00067.17 ERZ99076.1 - 8.9e-14 50.8 0.0 1e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TLP-20 PF06088.6 ERZ99077.1 - 0.093 12.3 0.7 0.18 11.5 0.2 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) AAA_5 PF07728.9 ERZ99078.1 - 5.5e-05 22.9 0.0 0.0003 20.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ERZ99078.1 - 8.1e-05 22.5 1.5 0.0019 18.1 0.0 3.5 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 ERZ99078.1 - 0.00025 21.2 3.5 0.00061 19.9 0.0 3.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ99078.1 - 0.0021 18.2 0.1 0.044 13.9 0.0 3.4 3 1 0 3 3 3 1 AAA domain Miro PF08477.8 ERZ99078.1 - 0.0036 17.7 0.0 0.021 15.3 0.0 2.4 1 0 0 1 1 1 1 Miro-like protein RNA_helicase PF00910.17 ERZ99078.1 - 0.013 15.6 0.1 1.2 9.3 0.0 3.7 3 0 0 3 3 3 0 RNA helicase AAA_16 PF13191.1 ERZ99078.1 - 0.037 13.9 0.0 1 9.3 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 ERZ99078.1 - 0.16 11.7 0.0 9.8 6.0 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain Pneumo_phosprot PF02478.11 ERZ99083.1 - 0.43 10.0 4.1 0.49 9.8 2.9 1.1 1 0 0 1 1 1 0 Pneumovirus phosphoprotein Mucin PF01456.12 ERZ99083.1 - 3.8 7.2 17.4 6.3 6.5 12.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein SUV3_C PF12513.3 ERZ99084.1 - 0.086 12.3 0.1 0.086 12.3 0.1 3.6 4 0 0 4 4 4 0 Mitochondrial degradasome RNA helicase subunit C terminal DUF869 PF05911.6 ERZ99084.1 - 2.1 6.4 77.6 3 5.9 47.7 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) CENP-F_leu_zip PF10473.4 ERZ99084.1 - 2.4 8.0 96.7 0.62 9.9 19.5 5.5 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 ERZ99084.1 - 4.9 6.2 29.5 0.73 8.9 2.3 3.0 1 1 1 3 3 3 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 ERZ99085.1 - 0.039 13.8 90.4 0.1 12.4 13.5 5.5 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.14 ERZ99085.1 - 0.46 8.1 83.7 15 3.1 42.6 2.1 1 1 0 1 1 1 0 Myosin tail Reo_sigmaC PF04582.7 ERZ99085.1 - 0.73 8.9 22.2 0.077 12.1 4.4 2.5 2 1 0 2 2 2 0 Reovirus sigma C capsid protein GAS PF13851.1 ERZ99085.1 - 3.9 6.6 95.8 9.4 5.3 14.3 4.0 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 ERZ99085.1 - 5.3 6.7 79.3 0.5 10.0 9.0 4.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding zf-CCHC PF00098.18 ERZ99086.1 - 7.4e-07 28.8 0.6 7.4e-07 28.8 0.4 1.7 2 0 0 2 2 2 1 Zinc knuckle Retrotrans_gag PF03732.12 ERZ99086.1 - 1.9e-05 24.6 0.3 0.00021 21.2 0.0 2.6 2 0 0 2 2 2 1 Retrotransposon gag protein Hpr_kinase_N PF02603.11 ERZ99090.1 - 0.14 11.8 1.0 1.1 8.9 0.2 2.0 1 1 1 2 2 2 0 HPr Serine kinase N terminus DIE2_ALG10 PF04922.7 ERZ99092.1 - 5.9e-114 381.0 31.2 8e-114 380.5 21.6 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family DUF1218 PF06749.7 ERZ99092.1 - 0.071 13.5 0.5 0.51 10.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) TLD PF07534.11 ERZ99093.1 - 0.016 15.1 0.7 0.025 14.5 0.5 1.3 1 1 0 1 1 1 0 TLD XLF PF09302.6 ERZ99094.1 - 0.016 14.9 0.2 0.028 14.2 0.2 1.4 1 0 0 1 1 1 0 XLF (XRCC4-like factor) Glucan_synthase PF02364.10 ERZ99094.1 - 0.034 12.0 0.3 0.049 11.5 0.2 1.2 1 0 0 1 1 1 0 1,3-beta-glucan synthase component MerR PF00376.18 ERZ99096.1 - 6.7e-08 31.9 0.1 2e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 MerR family regulatory protein HTH_OrfB_IS605 PF12323.3 ERZ99096.1 - 2e-07 30.2 0.1 5.8e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.1 ERZ99096.1 - 0.00015 21.5 0.0 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 MerR HTH family regulatory protein HTH_17 PF12728.2 ERZ99096.1 - 0.0002 21.5 1.1 0.00046 20.3 0.0 2.1 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_28 PF13518.1 ERZ99096.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Exc PF07825.6 ERZ99096.1 - 0.058 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Excisionase-like protein HTH_23 PF13384.1 ERZ99096.1 - 0.15 11.7 0.8 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain AAA_5 PF07728.9 ERZ99097.1 - 1.5e-07 31.2 0.0 0.00014 21.6 0.0 3.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ERZ99097.1 - 9.2e-06 25.8 9.3 0.0011 19.1 0.0 4.9 6 0 0 6 6 6 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ99097.1 - 0.00045 20.3 0.1 0.062 13.4 0.0 4.2 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ERZ99097.1 - 0.0071 16.3 0.1 5.3 6.9 0.0 4.4 4 0 0 4 4 4 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 ERZ99097.1 - 0.016 15.2 0.0 1.2 9.2 0.0 3.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.1 ERZ99097.1 - 1.2 8.9 0.0 31 4.4 0.0 2.9 3 0 0 3 3 3 0 Part of AAA domain RRN3 PF05327.6 ERZ99098.1 - 6.9e-110 367.7 14.7 4.1e-108 361.9 10.2 2.0 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Endomucin PF07010.7 ERZ99098.1 - 0.056 12.7 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 Endomucin MA3 PF02847.12 ERZ99099.1 - 2.1e-23 82.1 0.3 2.6e-21 75.4 0.1 2.5 2 0 0 2 2 2 2 MA3 domain MIF4G PF02854.14 ERZ99099.1 - 5e-13 48.9 1.6 1.3e-12 47.5 1.1 1.7 1 0 0 1 1 1 1 MIF4G domain DUF3250 PF11618.3 ERZ99099.1 - 0.025 14.7 0.1 0.068 13.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3250) UCR_hinge PF02320.11 ERZ99100.1 - 2.1e-22 78.8 3.5 3e-22 78.3 2.5 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Euplotes_phero PF05842.6 ERZ99100.1 - 0.051 13.9 0.1 0.07 13.4 0.1 1.2 1 0 0 1 1 1 0 Euplotes octocarinatus mating pheromone protein CHCH PF06747.8 ERZ99100.1 - 0.19 11.6 1.8 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 CHCH domain Pet191_N PF10203.4 ERZ99100.1 - 0.61 10.1 3.4 0.91 9.6 2.3 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.7 ERZ99100.1 - 0.69 9.8 2.9 4.5 7.1 2.0 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) zf-TAZ PF02135.11 ERZ99100.1 - 0.86 9.6 6.8 1.1 9.3 4.7 1.3 1 1 0 1 1 1 0 TAZ zinc finger CBS PF00571.23 ERZ99101.1 - 7.3e-29 99.2 7.3 7.6e-13 48.0 0.1 4.2 4 0 0 4 4 4 4 CBS domain RRM_1 PF00076.17 ERZ99102.1 - 4.6e-60 199.1 0.1 8.3e-21 73.4 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ99102.1 - 5.9e-46 154.3 0.1 1.9e-14 53.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ99102.1 - 3.5e-30 103.6 0.6 1.3e-10 40.9 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ERZ99102.1 - 0.00043 19.9 0.0 3.6 7.4 0.0 3.4 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.5 ERZ99102.1 - 0.034 14.0 0.0 3.1 7.8 0.0 2.7 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) RRM_3 PF08777.6 ERZ99102.1 - 0.056 13.2 0.0 19 5.1 0.0 3.1 3 0 0 3 3 3 0 RNA binding motif Cullin_binding PF03556.10 ERZ99103.1 - 1.9e-42 144.1 0.7 2.4e-42 143.7 0.5 1.1 1 0 0 1 1 1 1 Cullin binding Dynamin_N PF00350.18 ERZ99105.1 - 8.3e-46 155.8 0.4 1.9e-45 154.6 0.0 1.9 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.15 ERZ99105.1 - 2.3e-16 59.4 2.4 1.6e-13 50.0 0.1 2.6 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.18 ERZ99105.1 - 4.2e-05 23.4 0.1 0.00021 21.2 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 ERZ99105.1 - 0.0013 19.1 0.1 0.0061 17.0 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein AAA_21 PF13304.1 ERZ99105.1 - 0.025 14.5 0.1 0.08 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain ECH_C PF13766.1 ERZ99106.1 - 5.2e-36 123.3 0.1 1.5e-35 121.8 0.0 1.7 2 0 0 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region ECH PF00378.15 ERZ99106.1 - 2.3e-31 108.8 0.0 4.8e-29 101.1 0.0 2.2 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family FliG_N PF14842.1 ERZ99106.1 - 0.067 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 FliG N-terminal domain Pkinase_Tyr PF07714.12 ERZ99107.1 - 0.00046 19.3 0.0 0.00068 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sec20 PF03908.8 ERZ99107.1 - 0.42 10.3 4.6 2.6 7.8 0.3 2.6 1 1 0 2 2 2 0 Sec20 Pkinase_Tyr PF07714.12 ERZ99108.1 - 1.5e-05 24.2 0.0 8.5e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99108.1 - 0.015 14.4 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain DJ-1_PfpI PF01965.19 ERZ99109.1 - 0.026 13.9 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family TraT PF05818.7 ERZ99115.1 - 0.0053 16.1 3.6 6.9 6.0 0.0 3.7 4 0 0 4 4 4 2 Enterobacterial TraT complement resistance protein SCO1-SenC PF02630.9 ERZ99115.1 - 0.0079 15.8 9.1 3.6 7.1 0.0 5.1 5 0 0 5 5 5 1 SCO1/SenC DUF72 PF01904.13 ERZ99115.1 - 0.015 15.0 8.0 18 4.9 0.0 5.1 5 1 0 5 5 5 0 Protein of unknown function DUF72 DUF2190 PF09956.4 ERZ99115.1 - 2.1 8.1 3.6 34 4.2 0.0 3.7 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2190) DUF4134 PF13572.1 ERZ99115.1 - 2.4 8.3 6.1 55 3.9 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF4134) Fer4_2 PF12797.2 ERZ99115.1 - 4 7.5 28.4 2.2 8.3 0.3 5.3 5 0 0 5 5 5 0 4Fe-4S binding domain TLD PF07534.11 ERZ99116.1 - 2.4e-10 40.5 0.8 3.8e-10 39.8 0.2 1.6 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99116.1 - 2.2e-06 27.4 1.3 2.1e-05 24.2 0.2 2.8 1 1 2 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ99116.1 - 0.06 13.3 0.1 0.18 11.8 0.1 1.9 1 0 0 1 1 1 0 BTB/POZ domain DUF1754 PF08555.5 ERZ99118.1 - 3.7 8.1 13.3 5.9 7.5 9.2 1.3 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) CAF-1_p150 PF11600.3 ERZ99118.1 - 6.7 6.0 30.7 7.5 5.8 21.3 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Pkinase_Tyr PF07714.12 ERZ99119.1 - 1.8e-52 177.9 0.0 2.4e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99119.1 - 4.1e-50 170.3 0.4 5.8e-50 169.8 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ99119.1 - 0.00019 20.6 0.1 0.00031 19.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ99119.1 - 0.0012 18.2 0.2 0.0028 17.0 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ERZ99119.1 - 0.0023 17.3 0.3 0.0047 16.3 0.2 1.7 1 1 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ERZ99119.1 - 0.0065 15.4 0.0 0.017 14.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ERZ99119.1 - 0.029 14.1 0.1 0.044 13.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.26 ERZ99121.1 - 6.6e-18 64.7 0.1 1.4e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99121.1 - 1.6e-14 54.1 0.8 2.9e-14 53.2 0.6 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ERZ99121.1 - 1.7e-05 24.5 2.2 0.00036 20.3 0.1 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch Complex1_49kDa PF00346.14 ERZ99122.1 - 1.3e-129 431.0 0.0 1.7e-129 430.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.14 ERZ99122.1 - 0.022 13.5 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 Nickel-dependent hydrogenase TLD PF07534.11 ERZ99123.1 - 3e-11 43.4 0.9 1.3e-10 41.3 0.3 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99123.1 - 6.9e-09 35.4 0.0 0.00021 21.1 0.0 2.7 1 1 1 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.26 ERZ99124.1 - 0.017 15.1 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain Pkinase_Tyr PF07714.12 ERZ99125.1 - 4.7e-18 65.1 0.0 7.5e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99125.1 - 4.4e-16 58.8 0.0 7.4e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain EB1_binding PF05937.6 ERZ99125.1 - 0.07 13.5 0.1 0.083 13.2 0.1 1.1 1 0 0 1 1 1 0 EB-1 Binding Domain Pkinase_Tyr PF07714.12 ERZ99126.1 - 3.4e-05 23.0 0.0 4.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99126.1 - 0.0076 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DnaB_2 PF07261.6 ERZ99126.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Replication initiation and membrane attachment Pkinase_Tyr PF07714.12 ERZ99127.1 - 5.1e-32 110.9 0.0 1.8e-31 109.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99127.1 - 7.8e-31 107.1 0.9 1.8e-30 105.9 0.6 1.7 1 1 0 1 1 1 1 Protein kinase domain LIM_bind PF01803.11 ERZ99128.1 - 0.39 9.7 8.7 0.19 10.8 2.5 2.0 2 0 0 2 2 2 0 LIM-domain binding protein Pkinase PF00069.20 ERZ99130.1 - 3.7e-24 85.2 1.5 1e-23 83.8 1.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99130.1 - 4.9e-24 84.7 0.0 9.1e-24 83.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.15 ERZ99130.1 - 0.25 10.8 6.6 0.24 10.9 0.7 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase dDENN PF03455.14 ERZ99131.1 - 0.04 14.0 0.1 0.066 13.2 0.1 1.4 1 0 0 1 1 1 0 dDENN domain Adeno_E1B_55K PF01696.12 ERZ99131.1 - 0.094 11.1 0.0 0.11 10.9 0.0 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen s48_45 PF07422.8 ERZ99132.1 - 0.068 13.2 0.3 0.087 12.9 0.2 1.2 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain Nucleoplasmin PF03066.10 ERZ99133.1 - 0.46 9.9 2.6 0.45 10.0 1.8 1.1 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 ERZ99133.1 - 9 6.6 9.7 11 6.3 6.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2347 PF09804.4 ERZ99135.1 - 1.3e-75 254.2 0.0 2.5e-75 253.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.4 ERZ99135.1 - 1.8e-09 36.6 0.0 0.00039 19.0 0.0 2.9 2 1 1 3 3 3 2 Transport protein Avl9 SPA PF08616.5 ERZ99135.1 - 6.3e-09 35.5 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.7 ERZ99135.1 - 0.00024 21.1 0.1 0.0047 16.9 0.0 2.7 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4484 PF14831.1 ERZ99135.1 - 0.00058 20.0 7.8 0.073 13.1 0.0 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF4484) Nop10p PF04135.7 ERZ99136.1 - 1.9e-21 75.4 0.3 2.3e-21 75.2 0.2 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Ion_trans PF00520.26 ERZ99137.1 - 9.7e-12 44.5 14.0 9.7e-12 44.5 9.7 1.8 2 0 0 2 2 2 1 Ion transport protein Pkinase PF00069.20 ERZ99139.1 - 1e-05 24.8 0.0 1.3e-05 24.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ERZ99140.1 - 7.2e-59 199.0 0.0 8.1e-59 198.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99140.1 - 1.3e-37 129.2 0.0 1.6e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ99140.1 - 7.1e-05 21.8 0.0 0.00028 19.9 0.0 1.8 2 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 ERZ99140.1 - 0.003 16.4 0.0 0.0049 15.7 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.17 ERZ99140.1 - 0.031 13.6 0.1 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ERZ99140.1 - 0.034 13.8 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 ERZ99140.1 - 0.15 11.6 0.1 0.42 10.1 0.1 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase TLD PF07534.11 ERZ99142.1 - 1e-16 61.1 0.0 3.2e-16 59.5 0.0 1.8 2 0 0 2 2 2 1 TLD BTB PF00651.26 ERZ99142.1 - 1.9e-14 53.5 0.5 5.2e-14 52.1 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ99142.1 - 1.4e-07 31.2 2.9 1.2e-06 28.2 0.4 2.7 1 1 2 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ERZ99143.1 - 5e-66 222.4 3.0 9.4e-31 106.8 1.1 6.4 5 1 1 6 6 6 6 Protein tyrosine kinase Pkinase PF00069.20 ERZ99143.1 - 2.9e-52 177.3 17.6 2.6e-25 89.0 1.3 7.0 5 1 1 6 6 6 6 Protein kinase domain Toxin_43 PF15604.1 ERZ99144.1 - 0.058 13.4 1.8 0.067 13.2 0.4 1.7 1 1 1 2 2 2 0 Putative toxin 43 DUF2992 PF11208.3 ERZ99144.1 - 0.066 13.1 5.9 0.59 10.0 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2992) DUF4364 PF14277.1 ERZ99144.1 - 0.11 12.0 1.4 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) Sec7 PF01369.15 ERZ99146.1 - 7.2e-47 159.5 2.7 1.6e-46 158.3 1.9 1.6 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 ERZ99146.1 - 1.1e-15 57.7 0.1 5.7e-15 55.5 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 ERZ99146.1 - 1.1e-12 48.0 0.1 1.5e-11 44.4 0.0 3.0 2 0 0 2 2 2 1 PH domain DUF964 PF06133.6 ERZ99147.1 - 0.0031 17.5 1.4 0.0031 17.5 1.0 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF964) Leu_zip PF15294.1 ERZ99147.1 - 0.032 13.3 4.1 0.039 13.0 2.8 1.2 1 0 0 1 1 1 0 Leucine zipper MCPsignal PF00015.16 ERZ99147.1 - 0.24 10.9 2.7 1.5 8.3 0.1 2.2 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RecX PF02631.11 ERZ99148.1 - 0.03 14.5 0.0 0.036 14.2 0.0 1.1 1 0 0 1 1 1 0 RecX family Ribosomal_L18e PF00828.14 ERZ99148.1 - 0.12 12.7 0.1 0.25 11.6 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein L18e/L15 CENP-Q PF13094.1 ERZ99149.1 - 0.31 11.0 8.9 0.62 10.0 5.7 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MreB_Mbl PF06723.8 ERZ99150.1 - 1.2e-06 27.3 0.0 0.11 11.0 0.0 3.2 3 0 0 3 3 3 3 MreB/Mbl protein HSP70 PF00012.15 ERZ99150.1 - 0.00082 17.4 0.0 0.22 9.3 0.0 4.0 4 1 0 4 4 4 1 Hsp70 protein StbA PF06406.6 ERZ99150.1 - 0.035 13.0 0.2 4.8 6.0 0.0 2.4 1 1 2 3 3 3 0 StbA protein DUF1730 PF08331.5 ERZ99150.1 - 0.29 10.8 1.9 0.9 9.2 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) zf-DHHC PF01529.15 ERZ99152.1 - 1.5e-42 144.9 11.1 1.5e-42 144.9 7.7 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase SecY PF00344.15 ERZ99152.1 - 0.019 13.8 0.4 0.019 13.8 0.3 1.5 2 0 0 2 2 2 0 SecY translocase Transglut_core3 PF13471.1 ERZ99152.1 - 0.093 12.5 1.9 0.16 11.8 1.3 1.3 1 0 0 1 1 1 0 Transglutaminase-like superfamily Chitin_synth_1 PF01644.12 ERZ99153.1 - 8.2e-77 256.5 0.5 2.2e-76 255.2 0.1 1.9 2 0 0 2 2 2 1 Chitin synthase Chitin_synth_1N PF08407.6 ERZ99153.1 - 1.2e-25 88.9 0.2 3.5e-25 87.4 0.1 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 ERZ99153.1 - 1.2e-22 80.0 0.0 7.3e-18 64.2 0.0 2.8 2 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 ERZ99153.1 - 7.1e-12 45.4 4.6 2.8e-10 40.2 3.2 2.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ERZ99153.1 - 4.3e-09 36.5 0.0 1.1e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF2514 PF10721.4 ERZ99153.1 - 0.082 12.5 0.7 0.15 11.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) TCTP PF00838.12 ERZ99153.1 - 0.31 11.0 4.2 0.25 11.3 1.5 1.8 2 0 0 2 2 2 0 Translationally controlled tumour protein SseC PF04888.7 ERZ99153.1 - 1.4 8.2 3.7 2.2 7.5 2.6 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Exo_endo_phos PF03372.18 ERZ99154.1 - 0.0015 18.5 0.1 0.0033 17.4 0.1 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family XhlA PF10779.4 ERZ99155.1 - 0.0003 20.6 4.4 0.0003 20.6 3.1 2.2 2 0 0 2 2 2 1 Haemolysin XhlA Reo_sigmaC PF04582.7 ERZ99155.1 - 0.0035 16.5 0.9 0.0035 16.5 0.7 2.0 2 0 0 2 2 2 1 Reovirus sigma C capsid protein Cauli_DNA-bind PF03310.8 ERZ99155.1 - 0.0077 16.0 2.5 0.013 15.3 0.9 2.0 2 0 0 2 2 2 1 Caulimovirus DNA-binding protein IncA PF04156.9 ERZ99155.1 - 0.038 13.5 0.4 0.038 13.5 0.3 1.6 2 0 0 2 2 2 0 IncA protein LOH1CR12 PF10158.4 ERZ99155.1 - 0.096 12.4 4.4 0.1 12.3 1.6 2.0 2 0 0 2 2 2 0 Tumour suppressor protein Cortex-I_coil PF09304.5 ERZ99155.1 - 0.16 12.0 5.3 0.42 10.6 3.7 1.7 1 0 0 1 1 1 0 Cortexillin I, coiled coil AAA_27 PF13514.1 ERZ99155.1 - 1.4 6.4 7.0 1.9 6.0 4.8 1.1 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 ERZ99155.1 - 5.3 6.9 13.3 2.1 8.2 6.5 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Exo_endo_phos PF03372.18 ERZ99156.1 - 0.00074 19.5 0.2 0.0017 18.3 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family XhlA PF10779.4 ERZ99157.1 - 0.0002 21.2 3.9 0.0002 21.2 2.7 2.2 2 0 0 2 2 2 1 Haemolysin XhlA Reo_sigmaC PF04582.7 ERZ99157.1 - 0.0017 17.6 0.9 0.0017 17.6 0.7 1.9 2 0 0 2 2 2 1 Reovirus sigma C capsid protein IncA PF04156.9 ERZ99157.1 - 0.042 13.4 1.6 0.047 13.2 0.3 1.6 2 0 0 2 2 2 0 IncA protein NID PF07292.8 ERZ99157.1 - 0.13 12.3 0.5 11 6.1 0.0 3.3 3 1 0 3 3 3 0 Nmi/IFP 35 domain (NID) LOH1CR12 PF10158.4 ERZ99157.1 - 0.14 11.9 4.7 0.13 12.0 1.8 2.0 2 0 0 2 2 2 0 Tumour suppressor protein Cortex-I_coil PF09304.5 ERZ99157.1 - 0.14 12.2 4.6 0.35 10.9 3.2 1.6 1 0 0 1 1 1 0 Cortexillin I, coiled coil TMF_DNA_bd PF12329.3 ERZ99157.1 - 1.8 8.4 12.6 0.68 9.7 6.0 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_27 PF13514.1 ERZ99157.1 - 3.4 5.2 7.3 4.6 4.8 5.1 1.1 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.1 ERZ99158.1 - 2.6e-18 63.9 12.7 0.012 15.6 0.1 9.0 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.2 ERZ99158.1 - 8.3e-16 57.2 7.6 0.00022 20.7 2.0 4.9 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ERZ99158.1 - 9.4e-15 54.1 12.7 5e-08 32.5 1.0 5.6 3 2 3 6 6 6 6 Leucine rich repeat LRR_1 PF00560.28 ERZ99158.1 - 4.3e-13 47.3 16.2 0.03 14.2 0.1 8.9 10 0 0 10 10 10 5 Leucine Rich Repeat LRR_7 PF13504.1 ERZ99158.1 - 2.7e-10 38.7 7.6 2.9 8.4 0.1 8.0 7 0 0 7 7 7 2 Leucine rich repeat F-box-like PF12937.2 ERZ99158.1 - 5e-05 22.9 0.4 0.0002 21.0 0.3 2.1 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.8 ERZ99158.1 - 4.2 8.0 10.1 8.5 7.0 1.2 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Herpes_ori_bp PF02399.10 ERZ99159.1 - 1.4e-10 39.8 1.1 6.3e-10 37.6 0.1 2.0 1 1 1 2 2 2 2 Origin of replication binding protein Polysacc_deac_1 PF01522.16 ERZ99160.1 - 6.3e-06 25.8 0.0 1.7e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide deacetylase Cu-binding_MopE PF11617.3 ERZ99160.1 - 0.00039 20.1 2.7 0.0058 16.3 1.2 2.8 2 0 0 2 2 2 1 Protein metal binding site DUF4098 PF13345.1 ERZ99161.1 - 9.7e-08 31.8 9.9 5.1e-07 29.5 1.2 3.2 2 1 0 3 3 3 2 Domain of unknown function (DUF4098) DUF872 PF05915.7 ERZ99161.1 - 0.00041 20.2 0.2 0.027 14.3 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic protein of unknown function (DUF872) DUF1533 PF07550.6 ERZ99161.1 - 3.9 7.5 10.0 0.99 9.4 2.0 3.4 2 2 0 2 2 2 0 Protein of unknown function (DUF1533) DUF2039 PF10217.4 ERZ99162.1 - 6.2e-09 35.7 8.6 1.2e-08 34.8 6.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zf-RING_5 PF14634.1 ERZ99162.1 - 0.073 12.8 4.1 0.15 11.8 2.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF2481 PF10654.4 ERZ99162.1 - 0.085 12.5 0.5 0.12 12.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) zf-C3HC4_3 PF13920.1 ERZ99162.1 - 0.17 11.5 3.6 0.26 10.9 2.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) p450 PF00067.17 ERZ99163.1 - 6.4e-57 193.0 0.1 6.9e-57 192.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_Tyr PF07714.12 ERZ99164.1 - 6.9e-18 64.6 0.0 4.6e-17 61.9 0.0 1.9 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99164.1 - 5.9e-15 55.1 1.7 1.2e-12 47.5 0.7 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99165.1 - 1.7e-17 63.3 0.0 3.8e-17 62.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99165.1 - 2.1e-16 59.8 0.0 4.6e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF2757 PF10955.3 ERZ99165.1 - 0.1 12.8 1.1 2 8.6 0.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2757) Lamp PF01299.12 ERZ99165.1 - 0.11 11.5 8.6 0.015 14.4 3.4 1.4 2 0 0 2 2 2 0 Lysosome-associated membrane glycoprotein (Lamp) CUB PF00431.15 ERZ99165.1 - 0.17 11.9 3.5 1.1 9.3 0.4 2.4 1 1 1 2 2 2 0 CUB domain Pkinase PF00069.20 ERZ99166.1 - 1.2e-27 96.7 0.4 1.6e-27 96.3 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99166.1 - 9e-27 93.7 0.1 5.9e-26 91.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ99166.1 - 0.00035 19.6 0.5 0.0016 17.5 0.0 2.1 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99166.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ERZ99166.1 - 0.028 13.6 0.1 0.046 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ERZ99166.1 - 0.049 12.9 0.1 0.07 12.4 0.1 1.2 1 0 0 1 1 1 0 RIO1 family AbiH PF14253.1 ERZ99166.1 - 1 8.9 13.3 4.8 6.6 9.2 1.9 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH Pkinase_Tyr PF07714.12 ERZ99167.1 - 2.5e-26 92.2 0.0 3e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99167.1 - 6.3e-22 77.9 2.0 1.5e-21 76.7 1.4 1.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ99167.1 - 0.0097 15.6 0.1 0.042 13.5 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ99167.1 - 0.031 13.3 0.0 0.054 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EzrA PF06160.7 ERZ99168.1 - 0.021 13.0 15.4 0.031 12.4 10.1 1.5 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Spc7 PF08317.6 ERZ99168.1 - 0.03 12.9 22.0 0.19 10.3 7.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein E2R135 PF11570.3 ERZ99168.1 - 0.046 13.8 2.4 0.49 10.4 0.2 2.2 1 1 1 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF4201 PF13870.1 ERZ99168.1 - 0.17 11.3 20.5 2.5 7.4 9.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) GAS PF13851.1 ERZ99168.1 - 0.2 10.8 17.7 0.26 10.4 12.3 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.10 ERZ99168.1 - 0.2 10.8 8.2 0.27 10.3 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.6 ERZ99168.1 - 0.23 11.2 21.9 0.77 9.5 3.7 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Fez1 PF06818.10 ERZ99168.1 - 0.31 11.0 16.1 0.14 12.1 5.4 2.5 1 1 1 2 2 2 0 Fez1 YojJ PF10372.4 ERZ99168.1 - 0.41 10.5 3.8 2.3 8.1 0.3 2.8 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF4094 PF13334.1 ERZ99168.1 - 0.52 10.7 7.3 0.97 9.8 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) TPR_MLP1_2 PF07926.7 ERZ99168.1 - 0.54 9.9 20.9 0.67 9.7 9.1 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 ERZ99168.1 - 0.72 9.4 22.7 5.9 6.4 15.7 2.0 1 1 0 1 1 1 0 IncA protein DUF1700 PF08006.6 ERZ99168.1 - 1.2 8.3 4.0 1 8.6 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) DUF3552 PF12072.3 ERZ99168.1 - 1.3 8.2 20.2 0.25 10.5 6.4 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF3552) DASH_Dad2 PF08654.5 ERZ99168.1 - 2.8 8.0 10.0 0.081 12.9 1.9 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad2 Atg14 PF10186.4 ERZ99168.1 - 2.8 6.8 14.1 7.9 5.3 9.8 1.7 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 V_ATPase_I PF01496.14 ERZ99168.1 - 4.7 4.9 10.3 6.7 4.4 7.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OmpH PF03938.9 ERZ99168.1 - 5.3 6.9 13.5 27 4.6 9.4 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1623 PF07785.6 ERZ99170.1 - 0.12 12.3 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1623) HSDR_N PF04313.9 ERZ99171.1 - 0.0021 17.8 0.0 0.0027 17.4 0.0 1.1 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) Fic PF02661.13 ERZ99173.1 - 2.3e-20 73.0 0.0 6e-20 71.7 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family Herpes_UL31 PF02718.9 ERZ99174.1 - 7 5.2 7.8 0.077 11.6 0.4 1.4 2 0 0 2 2 2 0 Herpesvirus UL31-like protein zf-dskA_traR PF01258.12 ERZ99176.1 - 3 7.6 5.3 7.1 6.4 0.3 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger CDK2AP PF09806.4 ERZ99177.1 - 0.089 13.0 0.0 6.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein Imm22 PF15592.1 ERZ99177.1 - 3.4 8.0 12.2 2.9 8.2 0.4 3.5 3 2 0 3 3 3 0 Immunity protein 22 DUF4298 PF14131.1 ERZ99177.1 - 6.1 6.7 10.3 10 6.0 0.1 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF4298) Sel1 PF08238.7 ERZ99178.1 - 2.9e-78 256.5 45.7 1.8e-13 50.6 0.7 7.0 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ERZ99178.1 - 2.5e-06 27.5 26.7 0.09 13.2 0.2 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat MIT PF04212.13 ERZ99178.1 - 5.7e-05 22.9 27.4 0.53 10.1 0.1 6.2 4 1 2 6 6 6 4 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ99178.1 - 0.00012 22.0 22.5 0.41 10.9 0.2 7.6 6 1 0 6 6 6 2 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ERZ99178.1 - 0.0024 17.5 7.1 24 4.7 0.0 5.7 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation TPR_11 PF13414.1 ERZ99178.1 - 0.0027 17.2 43.5 0.044 13.4 5.8 5.7 1 1 4 5 5 5 3 TPR repeat Flu_M1_C PF08289.6 ERZ99178.1 - 0.0038 17.2 0.0 30 4.7 0.0 4.3 1 1 4 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain CitT PF12431.3 ERZ99178.1 - 0.0047 16.9 0.0 1.4 9.0 0.0 3.1 3 0 0 3 3 3 1 Transcriptional regulator Peptidase_C14 PF00656.17 ERZ99178.1 - 0.017 14.8 0.0 4.8 6.8 0.0 3.1 1 1 1 2 2 2 0 Caspase domain TPR_16 PF13432.1 ERZ99178.1 - 0.27 11.9 8.6 1.5 9.6 0.2 4.0 1 1 1 4 4 4 0 Tetratricopeptide repeat YlbE PF14003.1 ERZ99178.1 - 0.69 10.0 4.8 21 5.2 0.0 3.8 3 2 1 4 4 4 0 YlbE-like protein Apc3 PF12895.2 ERZ99178.1 - 1.1 9.4 30.2 3.4 7.8 6.8 4.5 2 2 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3674 PF12426.3 ERZ99178.1 - 1.5 8.3 8.6 1.4 8.3 0.0 4.2 6 0 0 6 6 6 0 RNA dependent RNA polymerase NUMOD1 PF07453.8 ERZ99178.1 - 1.7 8.5 4.8 1.5e+02 2.4 0.0 4.6 5 0 0 5 5 5 0 NUMOD1 domain B2-adapt-app_C PF09066.5 ERZ99178.1 - 2.4 8.0 5.2 3.5 7.5 0.2 3.3 1 1 3 4 4 4 0 Beta2-adaptin appendage, C-terminal sub-domain Sel1 PF08238.7 ERZ99179.1 - 2.4e-38 129.6 26.0 1.2e-12 48.0 2.1 5.1 4 1 1 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ERZ99179.1 - 3e-07 30.4 9.5 0.036 14.5 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat zinc-ribbons_6 PF07191.7 ERZ99179.1 - 0.0011 18.6 0.5 0.0023 17.6 0.3 1.5 1 0 0 1 1 1 1 zinc-ribbons TPR_17 PF13431.1 ERZ99179.1 - 0.0084 16.2 9.6 3.2 8.1 0.1 4.8 4 2 1 5 5 5 2 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ERZ99179.1 - 0.022 14.4 1.1 26 4.6 0.0 3.6 3 1 1 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation DUF2616 PF11077.3 ERZ99179.1 - 0.046 13.2 10.4 0.081 12.4 7.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2616) MIT PF04212.13 ERZ99179.1 - 0.049 13.5 17.0 1.4 8.8 0.1 4.1 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Leuk-A4-hydro_C PF09127.6 ERZ99179.1 - 0.12 11.9 3.4 0.65 9.5 0.2 2.4 1 1 2 3 3 3 0 Leukotriene A4 hydrolase, C-terminal TPR_19 PF14559.1 ERZ99179.1 - 1.7 9.0 5.1 12 6.3 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat PocR PF10114.4 ERZ99179.1 - 6.5 5.8 6.4 0.74 8.9 0.9 1.9 3 0 0 3 3 3 0 Sensory domain found in PocR Cohesin PF00963.13 ERZ99180.1 - 0.065 13.0 0.0 0.076 12.8 0.0 1.1 1 0 0 1 1 1 0 Cohesin domain p450 PF00067.17 ERZ99181.1 - 2e-49 168.3 0.0 2.7e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 tRNA_NucTransf2 PF09249.6 ERZ99181.1 - 0.07 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain HLH PF00010.21 ERZ99183.1 - 1.7e-11 43.6 3.7 1.7e-11 43.6 2.6 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain RHD3 PF05879.7 ERZ99184.1 - 1.9e-250 832.8 16.1 6e-220 732.0 10.1 2.0 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 ERZ99184.1 - 8.7e-08 31.5 6.3 1.2e-07 31.1 0.1 2.6 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.18 ERZ99184.1 - 2e-06 27.7 0.0 5.4e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ99184.1 - 8.9e-06 25.6 0.0 8.9e-06 25.6 0.0 2.6 2 1 0 2 2 2 1 Dynamin family AAA_28 PF13521.1 ERZ99184.1 - 5.7e-05 23.1 0.0 0.00018 21.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 ERZ99184.1 - 0.00014 22.2 0.0 0.00043 20.7 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Phasin PF05597.6 ERZ99184.1 - 0.059 13.1 8.6 0.31 10.7 0.8 3.5 2 1 2 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DPBB_1 PF03330.13 ERZ99185.1 - 2.8e-12 46.4 0.2 4.4e-12 45.8 0.1 1.4 1 1 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 ERZ99185.1 - 0.00048 19.7 0.1 0.00053 19.6 0.1 1.3 1 0 0 1 1 1 1 Barwin family Cerato-platanin PF07249.7 ERZ99185.1 - 0.019 14.9 0.0 0.028 14.4 0.0 1.3 1 1 0 1 1 1 0 Cerato-platanin Sel1 PF08238.7 ERZ99186.1 - 2.3e-43 145.6 11.0 5.3e-08 33.2 0.0 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ERZ99186.1 - 0.018 14.9 10.8 0.92 9.4 0.3 4.3 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain EF-hand_10 PF14788.1 ERZ99186.1 - 0.078 12.6 0.1 41 3.9 0.0 3.4 3 0 0 3 3 3 0 EF hand TPR_11 PF13414.1 ERZ99186.1 - 0.16 11.6 15.5 8.5 6.1 0.1 4.8 1 1 4 5 5 5 0 TPR repeat DUF2235 PF09994.4 ERZ99186.1 - 0.26 10.6 1.1 3.1 7.0 0.1 2.7 2 1 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_17 PF13431.1 ERZ99186.1 - 3.4 8.1 11.1 8.6 6.8 0.2 5.0 6 1 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.7 ERZ99187.1 - 3.8e-66 218.0 22.6 2.2e-13 50.3 0.7 6.3 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ERZ99187.1 - 0.0021 17.8 18.1 0.43 10.4 0.1 5.2 2 2 3 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ERZ99187.1 - 0.0031 17.1 26.7 0.6 9.8 1.0 5.2 1 1 4 5 5 5 4 TPR repeat TPR_6 PF13174.1 ERZ99187.1 - 0.023 15.1 9.1 8.5 7.0 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat DB PF01682.14 ERZ99187.1 - 0.034 14.1 0.8 33 4.5 0.0 3.1 2 1 1 3 3 3 0 DB module Trefoil PF00088.13 ERZ99187.1 - 0.041 13.5 5.2 12 5.6 0.3 3.4 3 0 0 3 3 3 0 Trefoil (P-type) domain Surfac_D-trimer PF09006.6 ERZ99187.1 - 0.092 12.4 4.6 17 5.2 0.4 4.3 3 2 1 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_14 PF13428.1 ERZ99187.1 - 1.6 9.6 7.1 70 4.4 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Herpes_UL1 PF05259.6 ERZ99190.1 - 0.13 11.6 0.7 7.5 6.0 0.2 2.3 2 1 0 2 2 2 0 Herpesvirus glycoprotein L RRM_6 PF14259.1 ERZ99191.1 - 4e-05 23.4 0.0 4.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ERZ99191.1 - 0.05 13.2 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TrkA_N PF02254.13 ERZ99191.1 - 0.11 12.5 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 TrkA-N domain Pkinase_Tyr PF07714.12 ERZ99193.1 - 8.2e-54 182.3 0.0 3.3e-53 180.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99193.1 - 5.1e-50 170.0 0.0 5.1e-50 170.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ERZ99193.1 - 0.0062 15.9 0.3 0.021 14.1 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ERZ99193.1 - 0.014 14.4 0.3 0.034 13.2 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sec2p PF06428.6 ERZ99193.1 - 0.022 14.6 0.4 0.089 12.6 0.3 2.1 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p APH PF01636.18 ERZ99193.1 - 0.022 14.4 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ99193.1 - 0.056 12.4 0.0 0.09 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Syntaxin-6_N PF09177.6 ERZ99193.1 - 0.69 10.3 6.1 19 5.7 1.3 3.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal BTB PF00651.26 ERZ99194.1 - 2e-16 59.9 0.1 3.7e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ99194.1 - 0.00013 21.7 3.5 0.001 18.9 0.0 3.3 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ99194.1 - 0.0075 15.4 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) DDE_1 PF03184.14 ERZ99195.1 - 7.6e-11 41.5 0.0 8.3e-11 41.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-F_leu_zip PF10473.4 ERZ99196.1 - 0.009 15.8 45.4 0.1 12.4 7.4 3.2 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.3 ERZ99196.1 - 0.013 15.2 40.5 0.073 12.8 9.4 3.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Myosin_tail_1 PF01576.14 ERZ99196.1 - 0.11 10.1 40.4 0.65 7.6 27.8 2.2 1 1 0 1 1 1 0 Myosin tail SATase_N PF06426.9 ERZ99196.1 - 0.29 11.4 5.0 0.1 12.8 0.7 2.2 2 0 0 2 2 2 0 Serine acetyltransferase, N-terminal Tropomyosin_1 PF12718.2 ERZ99196.1 - 0.57 10.0 45.6 0.57 10.0 6.4 3.2 2 1 1 3 3 3 0 Tropomyosin like GAS PF13851.1 ERZ99196.1 - 0.99 8.5 50.1 0.35 10.0 12.7 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF724 PF05266.9 ERZ99196.1 - 1.2 8.7 35.0 0.6 9.6 9.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF724) ArdA PF07275.6 ERZ99196.1 - 1.7 8.8 6.2 0.38 10.9 1.5 1.8 1 1 1 2 2 2 0 Antirestriction protein (ArdA) ApoO PF09769.4 ERZ99196.1 - 3 7.5 8.2 1 9.0 2.6 2.1 2 1 0 2 2 2 0 Apolipoprotein O Pox_A_type_inc PF04508.7 ERZ99196.1 - 9 6.3 14.5 29 4.7 0.3 4.9 4 1 0 4 4 4 0 Viral A-type inclusion protein repeat DUF4164 PF13747.1 ERZ99196.1 - 9.6 6.4 27.4 8 6.6 2.8 4.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) Pkinase_Tyr PF07714.12 ERZ99197.1 - 1.5e-10 40.5 0.1 4.8e-10 38.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99197.1 - 0.0013 17.9 0.8 0.011 14.9 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Phage_GP20 PF06810.6 ERZ99197.1 - 0.66 9.4 14.1 4.3 6.7 6.4 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF3847 PF12958.2 ERZ99197.1 - 3.8 7.3 9.8 0.52 10.1 3.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) IncA PF04156.9 ERZ99197.1 - 3.8 7.0 13.4 5.1 6.6 9.0 1.4 1 1 0 1 1 1 0 IncA protein Bap31 PF05529.7 ERZ99197.1 - 6.7 6.1 9.2 9.8 5.5 6.4 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Curto_V2 PF07325.6 ERZ99198.1 - 0.076 12.6 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Curtovirus V2 protein Y2_Tnp PF04986.8 ERZ99199.1 - 0.19 11.4 1.7 0.33 10.6 1.1 1.5 1 0 0 1 1 1 0 Putative transposase Pkinase PF00069.20 ERZ99200.1 - 3.8e-77 258.9 0.1 4.6e-77 258.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99200.1 - 7.5e-46 156.2 0.0 9.3e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ99200.1 - 1.3e-11 44.0 0.0 3.3e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ERZ99200.1 - 0.00035 19.6 0.0 0.00071 18.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99200.1 - 0.0038 16.9 0.3 1.7 8.3 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family YebO PF13974.1 ERZ99206.1 - 0.1 12.3 0.5 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 YebO-like protein Reovirus_cap PF00979.12 ERZ99207.1 - 0.3 9.9 1.4 0.41 9.5 1.0 1.2 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 DUF4367 PF14285.1 ERZ99208.1 - 0.0098 15.2 2.4 0.011 15.0 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) DUF3244 PF11589.3 ERZ99208.1 - 0.085 12.5 1.4 0.1 12.2 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) ATG2_CAD PF13329.1 ERZ99208.1 - 0.12 11.9 1.1 0.21 11.1 0.6 1.5 1 1 1 2 2 2 0 Autophagy-related protein 2 CAD motif Sel1 PF08238.7 ERZ99209.1 - 3.8e-17 62.2 10.4 6.9e-08 32.8 0.1 3.5 3 0 0 3 3 3 2 Sel1 repeat TPR_16 PF13432.1 ERZ99209.1 - 0.0011 19.5 0.9 0.024 15.3 0.0 2.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ99209.1 - 0.0022 18.2 1.9 0.16 12.3 0.1 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ99209.1 - 0.023 15.1 3.3 1.3 9.6 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF4080 PF13311.1 ERZ99209.1 - 0.037 14.0 1.3 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) TPR_7 PF13176.1 ERZ99209.1 - 0.17 11.7 2.2 18 5.4 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ99209.1 - 0.18 11.4 4.9 0.9 9.2 0.1 3.1 3 1 0 3 3 3 0 TPR repeat TPR_1 PF00515.23 ERZ99209.1 - 0.32 10.6 11.1 4.1 7.1 0.2 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ99209.1 - 0.75 9.7 3.5 4 7.4 0.2 3.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ99209.1 - 3.9 7.4 12.6 8 6.5 0.3 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TraV PF09676.5 ERZ99211.1 - 0.01 16.5 2.1 0.018 15.7 1.4 1.5 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Peptidase_M22 PF00814.20 ERZ99213.1 - 0.0035 16.8 0.0 0.0047 16.4 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family Hydrolase_3 PF08282.7 ERZ99213.1 - 0.15 11.5 1.9 0.37 10.3 1.3 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HMG_box PF00505.14 ERZ99214.1 - 0.0032 17.6 0.4 0.0046 17.1 0.3 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box Adhes-Ig_like PF09085.5 ERZ99215.1 - 0.14 12.0 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like BTB PF00651.26 ERZ99216.1 - 6.8e-11 42.1 0.0 1.6e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ99216.1 - 3e-07 30.2 0.9 1.2e-05 25.1 0.1 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch Sel1 PF08238.7 ERZ99218.1 - 7e-55 182.2 28.4 7.2e-11 42.3 0.2 6.4 7 0 0 7 7 7 6 Sel1 repeat MIT PF04212.13 ERZ99218.1 - 0.082 12.7 22.7 5.8 6.8 0.1 5.9 4 2 2 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ERZ99218.1 - 0.58 10.7 16.6 5 7.8 0.2 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF659 PF04937.10 ERZ99220.1 - 1.5e-07 31.0 0.2 1.5e-07 31.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Alpha-amyl_C2 PF07821.7 ERZ99220.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Alpha-amylase C-terminal beta-sheet domain Nop52 PF05997.7 ERZ99221.1 - 0.035 13.5 0.1 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 Nucleolar protein,Nop52 DUF1211 PF06736.6 ERZ99221.1 - 0.087 12.9 0.3 0.25 11.4 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1211) Helicase_C PF00271.26 ERZ99221.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Helicase conserved C-terminal domain WD40 PF00400.27 ERZ99223.1 - 9.4e-52 171.1 17.3 7.4e-09 35.1 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 ERZ99223.1 - 0.00013 21.7 0.0 0.14 11.8 0.0 2.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ERZ99223.1 - 0.084 10.9 0.2 4.2 5.3 0.0 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF2418 PF10332.4 ERZ99224.1 - 1.1e-23 83.4 1.4 4.4e-23 81.4 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) FHA PF00498.21 ERZ99225.1 - 3.8e-18 65.3 0.0 8.3e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 FHA domain dsrm PF00035.20 ERZ99225.1 - 5.6e-12 46.0 0.1 4.8e-10 39.8 0.0 3.2 3 0 0 3 3 3 1 Double-stranded RNA binding motif Baculo_PEP_C PF04513.7 ERZ99225.1 - 0.0026 17.5 2.5 0.0058 16.4 1.7 1.5 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Ras PF00071.17 ERZ99226.1 - 1.7e-60 203.0 0.1 2e-60 202.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ERZ99226.1 - 2.1e-19 70.1 0.0 3.3e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ERZ99226.1 - 9.9e-13 47.6 0.0 1.3e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ERZ99226.1 - 1e-05 24.8 0.0 1.2e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ERZ99226.1 - 1.2e-05 25.2 0.0 1.5e-05 24.9 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ERZ99226.1 - 7.6e-05 22.2 0.0 0.00016 21.1 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Big_3_2 PF12245.3 ERZ99226.1 - 0.00058 19.3 0.2 1.2 8.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial Ig-like domain (group 3) DUF258 PF03193.11 ERZ99226.1 - 0.01 15.0 0.3 0.036 13.2 0.0 2.0 2 1 0 3 3 3 0 Protein of unknown function, DUF258 AAA_14 PF13173.1 ERZ99226.1 - 0.044 13.6 0.1 0.16 11.8 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.1 ERZ99226.1 - 0.054 13.4 0.1 0.11 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.15 ERZ99226.1 - 0.074 11.7 0.2 4 6.0 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit DUF385 PF04075.9 ERZ99226.1 - 0.081 12.8 0.1 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF385) AAA_22 PF13401.1 ERZ99226.1 - 0.082 13.0 0.0 0.82 9.8 0.0 2.3 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.5 ERZ99226.1 - 0.096 11.8 0.1 0.3 10.2 0.0 1.8 1 1 0 2 2 2 0 Signal recognition particle receptor beta subunit SpoIIE PF07228.7 ERZ99227.1 - 1.1e-11 44.8 0.0 2.2e-11 43.8 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 ERZ99227.1 - 3.5e-07 29.8 0.0 0.00079 18.8 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 ERZ99227.1 - 4.6e-07 29.4 0.0 9.1e-07 28.4 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C RRM_5 PF13893.1 ERZ99228.1 - 1e-14 54.0 0.9 3.7e-07 29.8 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ99228.1 - 3.5e-13 49.3 0.3 1.4e-05 25.0 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ERZ99228.1 - 1.2e-12 47.3 0.2 6.4e-06 25.8 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.17 ERZ99228.1 - 4.2e-12 45.5 1.0 2.7e-05 23.6 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.12 ERZ99228.1 - 1.4e-05 25.1 0.0 3.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 PWI domain zf-CCCH PF00642.19 ERZ99228.1 - 7.2e-05 22.3 2.1 0.00013 21.5 1.5 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.6 ERZ99228.1 - 0.0003 20.6 10.8 0.03 14.1 0.0 3.7 3 0 0 3 3 3 2 RNA binding motif DUF2533 PF10752.4 ERZ99228.1 - 0.17 12.1 5.4 0.52 10.6 3.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2533) Pkinase PF00069.20 ERZ99229.1 - 3.5e-42 144.3 0.0 3.9e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99229.1 - 2e-29 102.4 0.0 2.1e-29 102.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ERZ99229.1 - 2.7e-05 23.3 0.0 4.1e-05 22.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 ERZ99229.1 - 0.044 12.8 0.1 0.06 12.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ERZ99229.1 - 0.086 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 ERZ99229.1 - 0.098 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ERZ99230.1 - 7.1e-29 100.6 0.1 8.3e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99230.1 - 8.1e-29 100.5 0.3 9e-29 100.4 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ERZ99230.1 - 0.0018 17.2 0.0 0.0021 17.0 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ERZ99230.1 - 0.0049 15.9 0.1 0.0059 15.7 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ERZ99230.1 - 0.0093 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ERZ99230.1 - 0.01 15.2 0.2 0.013 14.8 0.1 1.2 1 0 0 1 1 1 0 RIO1 family WaaY PF06176.6 ERZ99230.1 - 0.015 14.5 0.1 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ERZ99230.1 - 0.082 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ERZ99231.1 - 2.9e-94 307.4 41.1 4.2e-11 43.1 0.3 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ERZ99231.1 - 2.5e-08 33.8 30.9 0.081 13.4 0.7 9.9 11 1 0 11 11 11 4 Tetratricopeptide repeat NifW PF03206.9 ERZ99231.1 - 0.008 16.2 3.3 4.1 7.5 0.1 3.3 3 1 0 3 3 3 2 Nitrogen fixation protein NifW Ribosomal_L32e PF01655.13 ERZ99231.1 - 0.084 12.9 0.2 2.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L32 BTB PF00651.26 ERZ99232.1 - 1.9e-12 47.1 0.2 6.2e-12 45.4 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ERZ99232.1 - 3.5e-11 43.2 2.2 4.9e-11 42.7 0.3 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99232.1 - 1.6e-05 24.6 0.1 0.00015 21.5 0.0 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF2414 PF10309.4 ERZ99234.1 - 0.052 13.2 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2414) TLD PF07534.11 ERZ99235.1 - 7.7e-13 48.6 1.3 3.6e-12 46.4 0.4 2.3 2 0 0 2 2 2 1 TLD BTB PF00651.26 ERZ99235.1 - 3.9e-10 39.6 0.6 1.3e-09 38.0 0.3 1.9 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ99235.1 - 1.6e-09 37.5 6.0 2e-06 27.5 0.5 4.0 3 1 1 4 4 4 3 BTB And C-terminal Kelch BTB PF00651.26 ERZ99236.1 - 3.6e-06 26.9 0.0 4.1e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain HMG_box PF00505.14 ERZ99237.1 - 0.024 14.8 1.6 0.32 11.2 0.0 2.6 1 1 0 2 2 2 0 HMG (high mobility group) box SH3BP5 PF05276.9 ERZ99237.1 - 0.03 13.6 0.2 0.034 13.4 0.2 1.1 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Pkinase_Tyr PF07714.12 ERZ99238.1 - 2e-31 109.0 0.0 3.2e-30 105.0 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99238.1 - 4.2e-31 108.0 0.0 1.6e-29 102.8 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain DZR PF12773.2 ERZ99238.1 - 7.5e-05 22.4 7.1 7.5e-05 22.4 4.9 6.8 4 2 2 6 6 6 3 Double zinc ribbon RXT2_N PF08595.6 ERZ99239.1 - 0.0047 16.7 1.4 0.0055 16.5 1.0 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal TRAP_alpha PF03896.11 ERZ99239.1 - 0.0087 15.0 0.3 0.01 14.8 0.2 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF4366 PF14283.1 ERZ99239.1 - 0.028 13.8 1.4 0.034 13.5 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Sigma70_ner PF04546.8 ERZ99239.1 - 0.037 13.6 6.1 0.045 13.3 4.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 ERZ99239.1 - 0.053 13.8 8.0 0.07 13.4 5.5 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.6 ERZ99239.1 - 0.061 11.1 1.5 0.07 10.9 1.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.9 ERZ99239.1 - 0.09 10.7 1.7 0.093 10.7 1.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleoplasmin PF03066.10 ERZ99239.1 - 0.097 12.1 10.1 0.11 11.9 7.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin YL1 PF05764.8 ERZ99239.1 - 0.13 11.8 9.2 0.15 11.6 6.4 1.0 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.7 ERZ99239.1 - 0.51 9.5 6.7 0.6 9.3 4.6 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.5 ERZ99239.1 - 0.85 9.8 9.5 1.1 9.5 6.6 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.4 ERZ99239.1 - 2.4 6.8 10.6 2.7 6.6 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Tmemb_9 PF05434.6 ERZ99239.1 - 2.6 7.7 4.1 41 3.8 2.9 2.1 1 1 0 1 1 1 0 TMEM9 Myc_N PF01056.13 ERZ99239.1 - 4 6.5 7.5 4.6 6.3 5.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.7 ERZ99239.1 - 5.4 4.8 11.3 6.2 4.6 7.8 1.0 1 0 0 1 1 1 0 Nop14-like family Sipho_tail PF05709.6 ERZ99242.1 - 0.083 12.0 0.6 0.097 11.7 0.4 1.1 1 0 0 1 1 1 0 Phage tail protein DUF4468 PF14730.1 ERZ99242.1 - 0.1 12.2 0.4 0.13 12.0 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Pkinase PF00069.20 ERZ99245.1 - 1e-69 234.6 0.0 2.5e-69 233.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99245.1 - 4.6e-34 117.6 0.0 4.9e-28 97.9 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ERZ99245.1 - 5.8e-06 25.4 3.2 0.016 14.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 ERZ99245.1 - 0.0015 17.9 3.3 0.0026 17.1 2.3 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ERZ99245.1 - 0.057 13.1 0.0 1.1 8.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family CENP-K PF11802.3 ERZ99245.1 - 0.063 12.5 3.0 0.1 11.8 2.1 1.2 1 0 0 1 1 1 0 Centromere-associated protein K DUF3394 PF11874.3 ERZ99246.1 - 0.13 11.7 0.2 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) Med28 PF11594.3 ERZ99247.1 - 0.013 15.6 8.1 0.013 15.6 5.6 1.9 1 1 1 2 2 2 0 Mediator complex subunit 28 MA3 PF02847.12 ERZ99247.1 - 0.19 11.4 3.4 2.3 7.9 1.0 2.5 2 0 0 2 2 2 0 MA3 domain KMP11 PF03037.11 ERZ99247.1 - 0.19 12.3 1.4 0.97 10.0 0.1 2.2 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 Muted PF14942.1 ERZ99247.1 - 0.2 11.5 9.8 0.29 11.0 6.8 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Reo_sigmaC PF04582.7 ERZ99247.1 - 0.21 10.7 3.7 0.27 10.3 2.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF2018 PF09442.5 ERZ99247.1 - 0.41 11.2 4.5 0.91 10.1 1.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2018) COG2 PF06148.6 ERZ99247.1 - 0.48 10.2 8.7 2.7 7.8 1.6 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF724 PF05266.9 ERZ99247.1 - 0.96 9.0 14.3 0.13 11.9 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Fib_alpha PF08702.5 ERZ99247.1 - 1 9.4 13.0 1.9 8.5 8.8 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Synaptobrevin PF00957.16 ERZ99247.1 - 2 8.0 7.8 5.9 6.5 1.0 2.3 2 0 0 2 2 2 0 Synaptobrevin Mod_r PF07200.8 ERZ99247.1 - 2.1 8.2 19.2 2.4 8.0 3.6 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein UPF0449 PF15136.1 ERZ99247.1 - 5.3 7.3 9.0 46 4.3 6.2 2.5 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 OmpH PF03938.9 ERZ99247.1 - 7.8 6.4 18.0 18 5.2 7.1 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Atg14 PF10186.4 ERZ99247.1 - 8.3 5.2 15.7 11 4.9 1.5 1.7 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Pox_A22 PF04848.8 ERZ99248.1 - 0.093 12.5 0.5 0.17 11.7 0.4 1.5 1 0 0 1 1 1 0 Poxvirus A22 protein zf-CCHC PF00098.18 ERZ99249.1 - 2.3e-07 30.3 0.6 4.2e-07 29.5 0.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 ERZ99249.1 - 0.027 14.1 0.3 0.051 13.2 0.2 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 ERZ99249.1 - 0.057 13.0 0.2 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle PAXNEB PF05625.6 ERZ99249.1 - 0.19 10.5 1.2 0.27 10.0 0.9 1.2 1 0 0 1 1 1 0 PAXNEB protein PRT_C PF08372.5 ERZ99251.1 - 0.03 13.8 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal SCA7 PF08313.7 ERZ99252.1 - 7.4e-20 70.3 0.5 7.4e-20 70.3 0.3 1.7 2 0 0 2 2 2 1 SCA7, zinc-binding domain DUF667 PF05018.8 ERZ99252.1 - 0.035 13.3 0.1 0.043 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF667) Mer2 PF09074.5 ERZ99253.1 - 0.0098 15.8 0.0 0.012 15.6 0.0 1.0 1 0 0 1 1 1 1 Mer2 DUF3659 PF12396.3 ERZ99253.1 - 0.054 13.1 0.8 0.71 9.5 0.5 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3659) eIF-1a PF01176.14 ERZ99253.1 - 0.11 11.9 0.2 4.2 6.8 0.0 2.5 1 1 2 3 3 3 0 Translation initiation factor 1A / IF-1 SLEI_Leptospira PF07620.6 ERZ99253.1 - 0.28 11.0 1.4 3.6 7.5 0.0 3.0 3 0 0 3 3 3 0 SLEI UvrD-helicase PF00580.16 ERZ99254.1 - 1.4e-06 27.8 0.1 2.3e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 ERZ99254.1 - 2.9e-06 26.9 0.1 0.0081 15.6 0.0 2.3 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 ERZ99254.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain UvrD_C PF13361.1 ERZ99256.1 - 5.1e-13 49.2 2.3 2.3e-09 37.1 0.0 3.3 3 1 1 4 4 4 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 ERZ99256.1 - 1.3e-06 28.4 0.1 4e-05 23.6 0.1 3.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ERZ99256.1 - 5.8e-05 22.5 2.8 5.8e-05 22.5 1.9 4.4 4 1 0 4 4 4 1 UvrD/REP helicase N-terminal domain TPR_11 PF13414.1 ERZ99256.1 - 0.0016 18.0 12.7 0.0081 15.7 0.4 4.2 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.12 ERZ99256.1 - 0.059 13.3 0.1 0.059 13.3 0.0 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 ERZ99256.1 - 0.089 12.9 8.2 2.4 8.3 5.7 3.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ERZ99256.1 - 0.12 12.2 3.2 26 4.8 0.0 4.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.15 ERZ99256.1 - 1.1 8.8 8.9 5.4 6.6 1.4 4.3 2 1 2 4 4 4 0 Region in Clathrin and VPS TPR_1 PF00515.23 ERZ99256.1 - 1.5 8.5 18.6 0.79 9.4 0.2 5.0 4 1 2 6 6 6 0 Tetratricopeptide repeat bPH_3 PF14470.1 ERZ99257.1 - 0.02 15.1 0.8 0.19 12.0 0.3 2.6 2 0 0 2 2 2 0 Bacterial PH domain F-box-like PF12937.2 ERZ99259.1 - 2.1e-10 40.1 2.2 3.2e-10 39.5 0.5 2.1 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 ERZ99259.1 - 3.1e-09 36.2 2.6 6.3e-09 35.2 1.8 1.6 1 0 0 1 1 1 1 F-box domain PP2 PF14299.1 ERZ99259.1 - 2.8e-08 33.3 0.3 5.1e-08 32.4 0.2 1.5 1 0 0 1 1 1 1 Phloem protein 2 PRANC PF09372.5 ERZ99259.1 - 0.027 14.4 0.7 0.18 11.7 0.0 2.5 3 0 0 3 3 3 0 PRANC domain N1221 PF07923.8 ERZ99263.1 - 0.017 14.0 0.0 0.029 13.2 0.0 1.4 1 0 0 1 1 1 0 N1221-like protein bZIP_1 PF00170.16 ERZ99264.1 - 0.2 11.6 10.4 0.09 12.7 1.0 3.3 2 1 1 3 3 3 0 bZIP transcription factor LMBR1 PF04791.11 ERZ99264.1 - 4.1 5.8 5.0 4.5 5.7 3.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.20 ERZ99267.1 - 1.3e-30 106.4 0.0 1.4e-30 106.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99267.1 - 1.2e-27 96.6 0.0 1.3e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ99267.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ERZ99267.1 - 0.017 14.1 0.1 0.022 13.8 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ99267.1 - 0.038 12.9 0.0 0.051 12.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ERZ99267.1 - 0.058 12.7 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 RIO1 family HMG_box PF00505.14 ERZ99268.1 - 5.8e-19 68.1 2.3 6.5e-19 67.9 1.6 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99268.1 - 0.087 13.2 0.8 0.1 13.0 0.6 1.1 1 0 0 1 1 1 0 HMG-box domain DUF1992 PF09350.5 ERZ99269.1 - 6.5e-21 73.9 0.1 1.8e-20 72.5 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) Secretin_N_2 PF07655.8 ERZ99269.1 - 0.015 15.6 5.9 0.21 11.9 0.0 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain U3_assoc_6 PF08640.6 ERZ99270.1 - 6.1e-29 99.6 5.9 6.1e-29 99.6 4.1 3.2 2 1 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.1 ERZ99270.1 - 2.5e-05 24.5 0.0 4 8.3 0.0 6.4 9 0 0 9 9 9 1 Tetratricopeptide repeat NRDE-2 PF08424.5 ERZ99270.1 - 9.4e-05 21.4 26.7 0.0057 15.5 0.2 5.4 4 2 1 5 5 5 3 NRDE-2, necessary for RNA interference TPR_17 PF13431.1 ERZ99270.1 - 1.3 9.4 11.1 1.2e+02 3.3 0.0 7.0 10 0 0 10 10 10 0 Tetratricopeptide repeat Sm_multidrug_ex PF06695.6 ERZ99271.1 - 0.15 12.2 0.4 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Putative small multi-drug export protein Kelch_4 PF13418.1 ERZ99272.1 - 1.8e-18 66.0 14.2 0.002 17.8 0.0 7.0 5 3 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ99272.1 - 8.4e-18 64.0 5.0 0.0038 17.3 0.1 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ99272.1 - 4e-13 48.9 11.4 0.069 13.3 0.1 6.5 3 1 3 6 6 6 5 Kelch motif Kelch_5 PF13854.1 ERZ99272.1 - 1.8e-12 46.8 13.1 0.16 11.9 0.0 6.7 7 0 0 7 7 7 5 Kelch motif Kelch_1 PF01344.20 ERZ99272.1 - 5.5e-12 45.0 10.7 0.025 14.1 0.1 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ERZ99272.1 - 1.7e-08 33.8 5.6 0.78 9.6 0.0 6.8 6 2 0 6 6 6 3 Kelch motif Pkinase_Tyr PF07714.12 ERZ99273.1 - 2e-06 27.0 0.0 4.6e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99273.1 - 0.00013 21.2 0.0 0.00031 19.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ99275.1 - 8.3e-22 77.1 3.4 2.7e-12 46.9 0.1 2.8 2 1 1 3 3 3 2 Sel1 repeat Herpes_ori_bp PF02399.10 ERZ99278.1 - 4.2e-06 25.0 0.1 0.003 15.5 0.0 2.1 2 0 0 2 2 2 2 Origin of replication binding protein BTB PF00651.26 ERZ99279.1 - 0.019 14.9 0.1 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain SPRY PF00622.23 ERZ99280.1 - 4.3e-10 39.7 0.3 5e-10 39.5 0.2 1.0 1 0 0 1 1 1 1 SPRY domain SPRY PF00622.23 ERZ99281.1 - 2.8e-09 37.1 0.2 4.5e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ99281.1 - 1.3e-06 28.3 0.1 3.1e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Rho_N PF07498.7 ERZ99282.1 - 0.058 13.1 0.1 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain FliH PF02108.11 ERZ99282.1 - 0.086 12.7 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Flagellar assembly protein FliH Syja_N PF02383.13 ERZ99283.1 - 0.066 11.9 0.1 0.072 11.8 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain Sel1 PF08238.7 ERZ99284.1 - 8.2e-36 121.6 1.8 3.8e-13 49.6 0.2 4.2 3 1 1 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ERZ99284.1 - 0.02 15.3 5.4 0.18 12.3 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Exo_endo_phos_2 PF14529.1 ERZ99284.1 - 0.027 14.0 1.2 0.24 11.0 0.4 2.1 1 1 1 2 2 2 0 Endonuclease-reverse transcriptase TPR_11 PF13414.1 ERZ99284.1 - 0.083 12.5 5.5 1 9.0 0.2 2.8 1 1 1 2 2 2 0 TPR repeat Exo_endo_phos PF03372.18 ERZ99284.1 - 0.093 12.6 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family MIT PF04212.13 ERZ99284.1 - 0.34 10.8 6.0 5 7.0 0.1 3.2 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ99284.1 - 2.4 8.5 7.1 41 4.7 0.6 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat UPF0240 PF06784.6 ERZ99286.1 - 0.048 13.3 0.1 0.048 13.3 0.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) FAR1 PF03101.10 ERZ99287.1 - 5.9e-08 33.1 1.1 7.2e-08 32.8 0.8 1.1 1 0 0 1 1 1 1 FAR1 DNA-binding domain DUF2152 PF10222.4 ERZ99287.1 - 0.095 10.8 0.0 0.11 10.6 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) DBD_Tnp_Mut PF03108.10 ERZ99287.1 - 0.27 10.8 1.8 3.2 7.4 0.8 2.5 2 1 0 2 2 2 0 MuDR family transposase DUF561 PF04481.7 ERZ99288.1 - 0.15 10.9 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF561) FAR1 PF03101.10 ERZ99289.1 - 1.6e-08 34.9 1.6 2.3e-08 34.4 1.1 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain MULE PF10551.4 ERZ99290.1 - 0.0022 18.1 0.9 0.0076 16.3 0.6 2.0 1 0 0 1 1 1 1 MULE transposase domain zf-CCHC PF00098.18 ERZ99290.1 - 0.012 15.4 2.1 0.027 14.4 1.5 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 ERZ99290.1 - 0.12 12.0 1.8 0.45 10.2 1.3 2.1 1 1 0 1 1 1 0 Zinc knuckle FAR1 PF03101.10 ERZ99291.1 - 2.8e-08 34.1 2.1 8.4e-08 32.6 1.5 1.9 1 0 0 1 1 1 1 FAR1 DNA-binding domain zf-CCHC PF00098.18 ERZ99291.1 - 0.078 12.9 1.5 0.21 11.6 1.0 1.8 1 0 0 1 1 1 0 Zinc knuckle MHC_I PF00129.13 ERZ99292.1 - 0.044 13.1 2.1 0.82 8.9 0.7 2.2 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 ApoLp-III PF07464.6 ERZ99292.1 - 0.47 10.4 2.5 0.66 9.9 0.1 2.2 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) RRM_1 PF00076.17 ERZ99294.1 - 0.0002 20.8 0.0 0.0045 16.5 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ99294.1 - 0.087 12.8 0.2 7.1 6.6 0.0 3.1 2 1 1 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SPRY PF00622.23 ERZ99296.1 - 3.4e-13 49.7 0.8 5.8e-13 49.0 0.6 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ99296.1 - 3.4e-08 33.4 0.9 5e-07 29.7 0.1 2.5 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ERZ99297.1 - 1.2e-10 41.5 0.3 1.8e-10 40.9 0.2 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ERZ99297.1 - 0.00021 21.2 0.8 0.00038 20.4 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain Pkinase_Tyr PF07714.12 ERZ99298.1 - 5.5e-22 78.0 0.0 7.9e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99298.1 - 7.1e-22 77.7 0.0 1.7e-21 76.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain MRG PF05712.8 ERZ99299.1 - 6.1e-29 100.3 6.6 9.3e-29 99.7 4.6 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 ERZ99299.1 - 7.4e-13 47.9 0.7 2.3e-12 46.4 0.5 1.9 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 ERZ99299.1 - 1e-06 28.3 0.6 3.3e-06 26.6 0.4 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain FimP PF09766.4 ERZ99299.1 - 0.0071 15.4 4.3 0.013 14.5 3.0 1.5 1 0 0 1 1 1 1 Fms-interacting protein Cadherin PF00028.12 ERZ99301.1 - 0.019 15.2 0.0 0.027 14.6 0.0 1.2 1 1 0 1 1 1 0 Cadherin domain Pro_isomerase PF00160.16 ERZ99304.1 - 1.1e-48 165.3 0.1 1.3e-48 165.1 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ECH PF00378.15 ERZ99305.1 - 3.8e-61 206.3 0.0 4.9e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 ERZ99305.1 - 0.0034 17.5 0.0 0.0067 16.5 0.0 1.4 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region HTH_Mga PF08280.6 ERZ99305.1 - 0.014 15.0 0.1 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain Peptidase_C97 PF05903.9 ERZ99306.1 - 3e-36 124.4 0.1 3.5e-36 124.2 0.1 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 ERZ99306.1 - 0.033 14.1 0.1 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Lecithin retinol acyltransferase DUF3886 PF13025.1 ERZ99307.1 - 0.044 13.7 0.3 0.093 12.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Sel1 PF08238.7 ERZ99311.1 - 6.1e-80 261.9 15.8 2.1e-11 44.0 0.4 9.2 9 0 0 9 9 9 9 Sel1 repeat MIT PF04212.13 ERZ99311.1 - 0.0003 20.6 27.4 0.54 10.1 0.0 7.6 6 2 0 7 7 7 4 MIT (microtubule interacting and transport) domain NSF PF02071.15 ERZ99311.1 - 7.7 7.5 16.8 29 5.8 0.1 6.8 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat Exo_endo_phos PF03372.18 ERZ99312.1 - 0.016 15.1 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Tautomerase_2 PF14552.1 ERZ99313.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.4 1 1 0 1 1 1 0 Tautomerase enzyme STN1_2 PF09170.5 ERZ99313.1 - 0.1 12.3 0.2 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF4024 PF13216.1 ERZ99314.1 - 0.13 12.0 0.2 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) Ipi1_N PF12333.3 ERZ99316.1 - 4.5e-15 55.4 0.2 7.5e-14 51.5 0.0 3.4 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.1 ERZ99316.1 - 0.037 14.3 0.0 1.2 9.4 0.0 3.3 4 0 0 4 4 4 0 HEAT repeats CHD5 PF04420.9 ERZ99317.1 - 2.1e-42 144.5 3.0 2.7e-42 144.1 2.1 1.1 1 0 0 1 1 1 1 CHD5-like protein Ribosomal_L6e PF01159.14 ERZ99317.1 - 0.016 15.4 0.9 0.028 14.6 0.6 1.3 1 0 0 1 1 1 0 Ribosomal protein L6e DUF1090 PF06476.7 ERZ99317.1 - 0.12 12.0 3.3 0.17 11.5 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF1970 PF09301.5 ERZ99317.1 - 0.16 12.0 0.8 0.4 10.7 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1970) zf-C3HC PF07967.8 ERZ99318.1 - 1.4e-34 118.7 2.7 4.5e-32 110.6 0.0 2.6 2 1 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 ERZ99318.1 - 1e-05 25.3 0.5 1e-05 25.3 0.3 3.5 2 2 0 2 2 2 1 Rsm1-like Lar_restr_allev PF14354.1 ERZ99318.1 - 0.019 15.2 0.2 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Restriction alleviation protein Lar TEX19 PF15553.1 ERZ99318.1 - 0.025 14.4 0.6 0.047 13.5 0.4 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 DUF1041 PF06292.12 ERZ99318.1 - 0.033 14.3 1.7 0.088 12.9 0.3 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) LPP20 PF02169.11 ERZ99318.1 - 0.054 13.5 1.2 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 LPP20 lipoprotein PIF1 PF05970.9 ERZ99320.1 - 0.00041 19.4 0.0 0.00046 19.2 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase AAA_16 PF13191.1 ERZ99320.1 - 0.00099 19.1 0.0 0.0011 18.9 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 ERZ99320.1 - 0.0021 17.6 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ERZ99320.1 - 0.0022 17.2 0.0 0.0023 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ERZ99320.1 - 0.0078 15.7 0.0 0.0095 15.4 0.0 1.2 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 ERZ99320.1 - 0.011 16.5 0.3 0.016 16.0 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ERZ99320.1 - 0.011 15.6 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ERZ99320.1 - 0.012 14.5 0.0 0.012 14.5 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein IIGP PF05049.8 ERZ99320.1 - 0.013 14.3 0.1 0.013 14.2 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.13 ERZ99320.1 - 0.021 14.3 0.1 0.036 13.5 0.0 1.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.8 ERZ99320.1 - 0.022 13.7 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 ERZ99320.1 - 0.024 14.1 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 ERZ99320.1 - 0.024 14.0 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.22 ERZ99320.1 - 0.028 14.7 0.1 0.034 14.4 0.1 1.2 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.7 ERZ99320.1 - 0.033 13.8 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.18 ERZ99320.1 - 0.048 13.6 0.1 0.062 13.2 0.1 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 ERZ99320.1 - 0.051 13.7 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.1 ERZ99320.1 - 0.056 13.2 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain Viral_helicase1 PF01443.13 ERZ99320.1 - 0.058 12.9 0.1 0.075 12.5 0.1 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.9 ERZ99320.1 - 0.058 12.3 0.0 0.061 12.3 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain PhoH PF02562.11 ERZ99320.1 - 0.067 12.4 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein Adeno_IVa2 PF02456.10 ERZ99320.1 - 0.072 11.7 0.0 0.072 11.7 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein DAP3 PF10236.4 ERZ99320.1 - 0.078 11.8 0.0 0.085 11.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2075 PF09848.4 ERZ99320.1 - 0.085 11.8 0.1 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 ERZ99320.1 - 0.089 12.3 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 ERZ99320.1 - 0.091 11.3 0.1 0.097 11.2 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Torsin PF06309.6 ERZ99320.1 - 0.091 12.6 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 Torsin Zeta_toxin PF06414.7 ERZ99320.1 - 0.099 11.7 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.24 ERZ99320.1 - 0.1 12.7 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 ERZ99320.1 - 0.12 12.6 0.2 0.16 12.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ERZ99320.1 - 0.13 12.3 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain MCM PF00493.18 ERZ99320.1 - 0.14 10.9 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 MCM2/3/5 family ATP_bind_1 PF03029.12 ERZ99320.1 - 0.14 11.6 0.1 0.18 11.3 0.1 1.1 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF87 PF01935.12 ERZ99320.1 - 0.14 11.9 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 NTPase_1 PF03266.10 ERZ99320.1 - 0.14 11.8 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 NTPase Arf PF00025.16 ERZ99320.1 - 0.15 11.2 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF4477 PF14780.1 ERZ99323.1 - 0.0021 17.4 0.7 0.0037 16.6 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) CENP-W PF15510.1 ERZ99323.1 - 0.053 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Centromere kinetochore component W IF-2B PF01008.12 ERZ99324.1 - 1.5e-75 253.8 0.2 3.3e-75 252.6 0.0 1.7 2 1 0 2 2 2 1 Initiation factor 2 subunit family XPG_I PF00867.13 ERZ99325.1 - 2.2e-25 88.5 0.1 5.1e-25 87.3 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ERZ99325.1 - 1.1e-14 54.4 0.0 4e-14 52.6 0.0 1.9 1 1 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 ERZ99325.1 - 2.7e-09 36.8 0.0 4.7e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 ERZ99325.1 - 1.5e-05 25.1 0.0 3.5e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold V-ATPase_G PF03179.10 ERZ99327.1 - 1.7e-33 115.0 14.3 1.9e-33 114.8 9.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.13 ERZ99327.1 - 0.011 15.5 11.8 0.011 15.5 8.2 1.9 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) MMR_HSR1_C PF08438.5 ERZ99327.1 - 0.025 14.8 3.2 0.032 14.4 2.2 1.2 1 0 0 1 1 1 0 GTPase of unknown function C-terminal Nop25 PF09805.4 ERZ99327.1 - 0.034 14.2 7.6 0.041 13.9 5.3 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Tht1 PF04163.7 ERZ99327.1 - 0.092 11.1 1.6 0.096 11.0 1.1 1.0 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Herpes_UL95 PF03038.9 ERZ99327.1 - 0.096 11.5 2.2 0.11 11.3 1.5 1.1 1 0 0 1 1 1 0 UL95 family Seryl_tRNA_N PF02403.17 ERZ99327.1 - 0.51 10.3 7.8 1.1 9.2 5.4 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CDC37_N PF03234.9 ERZ99327.1 - 0.82 9.9 5.8 1.5 9.1 1.2 2.0 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Rotamase_2 PF13145.1 ERZ99327.1 - 2.3 8.8 9.4 3.1 8.4 6.5 1.2 1 0 0 1 1 1 0 PPIC-type PPIASE domain KfrA_N PF11740.3 ERZ99327.1 - 2.3 8.6 12.8 1.1 9.7 4.9 2.1 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term AAA_13 PF13166.1 ERZ99327.1 - 2.3 6.5 10.5 4.4 5.6 7.3 1.4 1 1 0 1 1 1 0 AAA domain OmpH PF03938.9 ERZ99327.1 - 2.9 7.7 12.9 3.8 7.4 9.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.1 ERZ99327.1 - 3.4 6.5 10.7 5.1 5.9 7.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Pribosyltran_N PF13793.1 ERZ99328.1 - 1.3e-45 153.8 1.7 2.9e-44 149.5 0.0 2.8 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 ERZ99328.1 - 5.3e-45 153.4 3.5 5.7e-44 150.0 2.4 2.1 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 ERZ99328.1 - 3.4e-07 30.0 0.6 1e-05 25.2 0.2 3.0 3 1 0 3 3 3 1 Phosphoribosyl transferase domain Glyco_hydro_17 PF00332.13 ERZ99328.1 - 0.035 13.1 0.1 6.4 5.7 0.0 3.0 3 0 0 3 3 3 0 Glycosyl hydrolases family 17 M11L PF11099.3 ERZ99330.1 - 0.0045 16.7 0.9 0.0073 16.0 0.2 1.6 1 1 1 2 2 2 1 Apoptosis regulator M11L like OTOS PF15182.1 ERZ99332.1 - 0.022 14.4 0.1 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Otospiralin Asp_protease_2 PF13650.1 ERZ99334.1 - 0.0069 16.8 0.0 0.016 15.6 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.15 ERZ99334.1 - 0.016 15.0 0.1 0.086 12.7 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease Scramblase PF03803.10 ERZ99336.1 - 0.04 13.0 1.7 0.085 11.9 0.1 2.0 2 0 0 2 2 2 0 Scramblase DUF3877 PF12993.2 ERZ99336.1 - 2.4 7.6 7.9 0.97 8.9 0.1 3.1 2 2 2 4 4 4 0 Domain of unknown function, E. rectale Gene description (DUF3877) vATP-synt_E PF01991.13 ERZ99336.1 - 6 6.0 11.4 0.44 9.7 1.3 2.6 3 0 0 3 3 3 0 ATP synthase (E/31 kDa) subunit Pkinase_Tyr PF07714.12 ERZ99337.1 - 3.7e-05 22.9 0.1 0.01 14.8 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ99337.1 - 0.00059 19.0 0.6 0.033 13.3 0.3 2.8 1 1 1 2 2 2 1 Protein kinase domain Misat_Tub_SegII PF10644.4 ERZ99337.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain DnaJ-X PF14308.1 ERZ99338.1 - 0.011 14.9 0.2 0.014 14.6 0.1 1.1 1 0 0 1 1 1 0 X-domain of DnaJ-containing Piwi PF02171.12 ERZ99344.1 - 6.4e-53 179.6 0.3 7.7e-39 133.4 0.0 2.3 1 1 1 2 2 2 2 Piwi domain PAZ PF02170.17 ERZ99344.1 - 1.1e-22 79.7 0.6 2.7e-22 78.5 0.4 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ99344.1 - 1.9e-13 49.5 0.0 4.3e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Piwi PF02171.12 ERZ99346.1 - 4.4e-97 324.6 0.0 6.2e-97 324.2 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ERZ99346.1 - 1.4e-19 69.7 0.1 3.3e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ERZ99346.1 - 9e-18 63.3 0.0 2.1e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Beta-lactamase PF00144.19 ERZ99348.1 - 1.5e-40 139.2 0.0 3.2e-40 138.1 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.15 ERZ99348.1 - 0.042 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Cyt-b5 PF00173.23 ERZ99349.1 - 1.7e-21 75.8 0.0 3.4e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.11 ERZ99349.1 - 6.8e-19 68.5 0.0 1.3e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ERZ99349.1 - 5.4e-10 38.6 0.1 1.5e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.19 ERZ99350.1 - 1.4e-39 135.5 2.6 1.8e-39 135.2 1.8 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.6 ERZ99350.1 - 6e-08 33.0 1.2 7.9e-08 32.6 0.8 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TPR_10 PF13374.1 ERZ99350.1 - 0.081 12.8 1.1 0.19 11.6 0.4 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Acyl-CoA_dh_1 PF00441.19 ERZ99351.1 - 1.7e-38 132.0 4.2 2.4e-38 131.5 2.9 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.23 ERZ99351.1 - 1.2e-20 73.0 0.0 2.6e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.14 ERZ99351.1 - 1.2e-19 69.5 0.0 2.6e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 ERZ99351.1 - 5e-19 68.9 0.0 1.7e-18 67.2 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 ERZ99351.1 - 7.6e-07 29.4 2.7 1.4e-06 28.5 1.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.23 ERZ99352.1 - 3.3e-21 74.8 0.1 6.7e-21 73.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.11 ERZ99352.1 - 1.4e-17 64.3 0.0 2.6e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ERZ99352.1 - 6.4e-10 38.3 0.2 1.5e-09 37.2 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain PPO1_DWL PF12142.3 ERZ99352.1 - 0.049 13.1 0.9 0.081 12.4 0.7 1.3 1 0 0 1 1 1 0 Polyphenol oxidase middle domain E1-E2_ATPase PF00122.15 ERZ99353.1 - 2.4e-59 200.1 2.8 2.4e-59 200.1 1.9 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ERZ99353.1 - 1.2e-28 101.0 0.0 4.5e-28 99.1 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ERZ99353.1 - 1.2e-21 76.4 0.0 3.1e-21 75.1 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_C PF00689.16 ERZ99353.1 - 1.4e-17 63.8 16.1 7.2e-15 54.9 2.0 3.7 4 0 0 4 4 4 2 Cation transporting ATPase, C-terminus HAD PF12710.2 ERZ99353.1 - 3.3e-15 56.7 0.0 3.6e-14 53.3 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ERZ99353.1 - 1.5e-14 53.1 0.0 3.3e-13 48.8 0.0 3.0 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ERZ99353.1 - 0.0021 17.6 5.8 0.053 13.0 0.6 3.7 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Noggin PF05806.7 ERZ99354.1 - 0.092 12.0 0.4 0.11 11.7 0.3 1.0 1 0 0 1 1 1 0 Noggin Tricorn_C1 PF14684.1 ERZ99356.1 - 0.017 15.0 2.3 0.021 14.6 0.9 1.8 1 1 1 2 2 2 0 Tricorn protease C1 domain SCF PF02404.10 ERZ99356.1 - 0.038 13.1 0.2 0.049 12.8 0.2 1.1 1 0 0 1 1 1 0 Stem cell factor GTP_EFTU PF00009.22 ERZ99359.1 - 0.079 12.3 0.3 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain FliS PF02561.9 ERZ99359.1 - 0.13 12.1 0.7 9.5 6.0 0.2 2.3 2 0 0 2 2 2 0 Flagellar protein FliS DEAD PF00270.24 ERZ99360.1 - 4.6e-05 22.9 0.1 7.3e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pkinase PF00069.20 ERZ99361.1 - 5.8e-06 25.6 2.3 8.3e-06 25.1 1.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99361.1 - 0.00016 20.8 0.5 0.00019 20.5 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2870 PF11069.3 ERZ99361.1 - 0.075 13.0 0.2 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) Striatin PF08232.7 ERZ99363.1 - 0.0001 22.6 2.8 0.00011 22.5 2.0 1.1 1 0 0 1 1 1 1 Striatin family BCAS2 PF05700.6 ERZ99363.1 - 0.00049 19.6 3.5 0.00061 19.3 2.4 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Microtub_assoc PF07989.6 ERZ99363.1 - 0.001 18.8 5.5 0.0032 17.2 1.9 2.1 1 1 1 2 2 2 1 Microtubule associated DUF1192 PF06698.6 ERZ99363.1 - 0.0015 18.2 1.7 0.025 14.4 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Shugoshin_N PF07558.6 ERZ99363.1 - 0.003 17.2 1.3 0.0048 16.5 0.4 1.8 1 1 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DivIC PF04977.10 ERZ99363.1 - 0.0034 16.8 2.7 0.005 16.2 1.7 1.4 1 1 0 1 1 1 1 Septum formation initiator HalX PF08663.5 ERZ99363.1 - 0.012 15.6 1.7 1.3 9.0 0.3 2.1 1 1 1 2 2 2 0 HalX domain GAS PF13851.1 ERZ99363.1 - 0.014 14.6 6.6 0.015 14.5 4.5 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF972 PF06156.8 ERZ99363.1 - 0.021 15.1 4.5 0.024 14.9 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_1 PF00170.16 ERZ99363.1 - 0.035 14.0 6.4 0.67 9.9 0.4 2.3 1 1 1 2 2 2 0 bZIP transcription factor Phlebovirus_NSM PF07246.6 ERZ99363.1 - 0.041 13.0 0.8 0.045 12.8 0.6 1.0 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF1160 PF06648.6 ERZ99363.1 - 0.05 13.3 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) ATG16 PF08614.6 ERZ99363.1 - 0.058 13.2 3.9 0.065 13.0 2.7 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2031 PF09592.5 ERZ99363.1 - 0.06 12.4 4.6 0.068 12.3 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) DUF4391 PF14335.1 ERZ99363.1 - 0.081 12.3 3.4 0.094 12.0 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Ten1_2 PF15490.1 ERZ99363.1 - 0.088 12.3 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit DUF2216 PF10226.4 ERZ99363.1 - 0.11 12.0 2.5 0.11 11.9 1.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) PhoU PF01895.14 ERZ99363.1 - 0.11 12.9 0.3 0.12 12.8 0.2 1.3 1 0 0 1 1 1 0 PhoU domain Cortex-I_coil PF09304.5 ERZ99363.1 - 0.11 12.4 4.7 0.2 11.6 3.2 1.4 1 1 0 1 1 1 0 Cortexillin I, coiled coil Ead_Ea22 PF13935.1 ERZ99363.1 - 0.12 12.6 3.0 0.14 12.4 2.1 1.1 1 0 0 1 1 1 0 Ead/Ea22-like protein CALCOCO1 PF07888.6 ERZ99363.1 - 0.13 10.4 3.0 0.14 10.4 2.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like WD40_alt PF14077.1 ERZ99363.1 - 0.14 11.8 2.8 2.3 7.9 0.5 2.2 1 1 0 2 2 2 0 Alternative WD40 repeat motif Leu_zip PF15294.1 ERZ99363.1 - 0.18 10.9 6.7 0.27 10.3 4.6 1.3 1 1 0 1 1 1 0 Leucine zipper Tnp_P_element PF12017.3 ERZ99363.1 - 0.23 10.6 1.4 0.26 10.4 1.0 1.2 1 0 0 1 1 1 0 Transposase protein DUF4315 PF14193.1 ERZ99363.1 - 0.24 11.3 4.5 0.28 11.1 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) IFP_35_N PF07334.8 ERZ99363.1 - 0.28 11.1 7.1 1 9.3 1.4 2.1 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus IncA PF04156.9 ERZ99363.1 - 0.31 10.6 4.0 0.34 10.4 2.7 1.1 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.10 ERZ99363.1 - 0.36 10.4 3.8 0.41 10.2 2.6 1.1 1 0 0 1 1 1 0 Mnd1 family TMF_DNA_bd PF12329.3 ERZ99363.1 - 0.51 10.1 7.7 0.9 9.3 5.3 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.9 ERZ99363.1 - 0.59 9.7 4.1 0.68 9.5 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.4 ERZ99363.1 - 1 8.2 4.0 1.1 8.1 2.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF904 PF06005.7 ERZ99363.1 - 1.1 9.6 9.1 1.1 9.6 4.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF904) TPD52 PF04201.10 ERZ99363.1 - 1.1 8.9 6.1 1.5 8.5 4.3 1.3 1 1 0 1 1 1 0 Tumour protein D52 family Protein_K PF12283.3 ERZ99363.1 - 1.1 9.1 3.4 3.7 7.4 0.1 2.6 2 1 1 3 3 3 0 Bacteriophage protein K APG6 PF04111.7 ERZ99363.1 - 1.5 7.8 6.2 1.5 7.7 4.3 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_2 PF07716.10 ERZ99363.1 - 1.7 8.5 5.9 4.4 7.1 1.2 2.4 1 1 0 2 2 2 0 Basic region leucine zipper TSC22 PF01166.13 ERZ99363.1 - 3.2 7.7 8.6 1.6 8.7 0.7 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family Pox_A_type_inc PF04508.7 ERZ99363.1 - 8.6 6.4 7.4 35 4.5 0.3 2.9 2 1 1 3 3 3 0 Viral A-type inclusion protein repeat Shugoshin_C PF07557.6 ERZ99365.1 - 0.14 11.6 0.3 0.25 10.8 0.2 1.4 1 0 0 1 1 1 0 Shugoshin C terminus Usp PF00582.21 ERZ99366.1 - 2.6e-23 82.7 0.1 4.5e-23 82.0 0.1 1.3 1 0 0 1 1 1 1 Universal stress protein family F-box-like PF12937.2 ERZ99367.1 - 6e-05 22.6 0.3 6e-05 22.6 0.2 1.8 2 0 0 2 2 2 1 F-box-like Plasmid_killer PF05015.8 ERZ99367.1 - 0.05 13.7 0.2 0.71 10.0 0.0 2.4 2 1 0 2 2 2 0 Plasmid maintenance system killer protein DNA_pol_A PF00476.15 ERZ99369.1 - 9.3e-80 268.0 0.0 1.4e-79 267.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A ENTH PF01417.15 ERZ99370.1 - 1.4e-51 173.5 0.2 2.9e-51 172.5 0.1 1.6 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 ERZ99370.1 - 4.6e-05 22.2 0.1 7.6e-05 21.5 0.1 1.4 1 0 0 1 1 1 1 ANTH domain AAA PF00004.24 ERZ99371.1 - 7.2e-82 272.1 0.0 1.3e-39 135.4 0.0 2.5 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ERZ99371.1 - 4.5e-12 46.3 0.1 0.0029 17.5 0.0 3.3 3 0 0 3 3 3 3 AAA ATPase domain AAA_2 PF07724.9 ERZ99371.1 - 1e-11 45.0 0.0 3.5e-06 27.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ERZ99371.1 - 6.3e-11 41.7 0.0 0.00012 21.2 0.0 3.3 2 2 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ERZ99371.1 - 5.2e-10 39.1 0.3 0.002 17.8 0.1 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ERZ99371.1 - 6.1e-09 35.8 0.0 0.0017 18.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ERZ99371.1 - 3.8e-08 34.1 0.0 0.00052 20.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ERZ99371.1 - 1.9e-07 30.9 2.2 0.36 10.5 0.1 3.8 2 2 2 4 4 4 3 Archaeal ATPase RNA_helicase PF00910.17 ERZ99371.1 - 4.3e-07 30.0 0.0 0.0069 16.5 0.0 2.7 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.8 ERZ99371.1 - 4.6e-07 28.9 0.0 0.0066 15.2 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_25 PF13481.1 ERZ99371.1 - 1.1e-06 28.1 0.7 0.003 17.0 0.0 3.3 2 2 1 3 3 3 1 AAA domain AAA_22 PF13401.1 ERZ99371.1 - 2e-06 27.9 4.3 0.069 13.2 0.8 4.2 2 2 1 3 3 3 1 AAA domain ABC_tran PF00005.22 ERZ99371.1 - 2.8e-06 27.6 0.2 0.11 12.7 0.0 2.6 2 1 0 2 2 2 2 ABC transporter Rad17 PF03215.10 ERZ99371.1 - 3.7e-06 25.9 0.0 0.00056 18.7 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_33 PF13671.1 ERZ99371.1 - 1.1e-05 25.3 0.0 0.013 15.4 0.0 2.7 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 ERZ99371.1 - 1.2e-05 25.1 0.4 0.13 11.9 0.0 3.5 3 2 1 4 4 3 2 NTPase NACHT PF05729.7 ERZ99371.1 - 1.8e-05 24.4 1.4 0.21 11.2 0.0 3.5 3 0 0 3 3 3 1 NACHT domain AAA_24 PF13479.1 ERZ99371.1 - 2.4e-05 24.0 2.1 0.015 14.8 0.2 2.5 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 ERZ99371.1 - 2.7e-05 23.2 0.0 0.14 11.0 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 ERZ99371.1 - 6.6e-05 22.3 0.1 0.0022 17.4 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein Bac_DnaA PF00308.13 ERZ99371.1 - 0.00022 20.9 0.0 0.0044 16.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_19 PF13245.1 ERZ99371.1 - 0.00036 20.2 2.3 0.43 10.3 0.1 3.0 4 0 0 4 4 2 2 Part of AAA domain AAA_10 PF12846.2 ERZ99371.1 - 0.00045 19.7 4.1 0.025 14.0 0.3 3.9 3 1 0 3 3 3 1 AAA-like domain AAA_3 PF07726.6 ERZ99371.1 - 0.001 18.7 0.0 1.2 8.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 ERZ99371.1 - 0.0014 17.7 0.7 0.27 10.3 0.0 2.9 3 1 0 3 3 2 1 Zeta toxin DUF258 PF03193.11 ERZ99371.1 - 0.0016 17.6 0.0 0.039 13.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AFG1_ATPase PF03969.11 ERZ99371.1 - 0.0018 17.1 0.0 0.048 12.4 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase UPF0079 PF02367.12 ERZ99371.1 - 0.002 17.7 0.1 0.72 9.4 0.0 2.6 2 1 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ERZ99371.1 - 0.0047 16.9 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 ERZ99371.1 - 0.0047 16.9 5.2 0.87 9.4 0.0 3.9 3 2 1 4 4 4 1 AAA domain Mg_chelatase PF01078.16 ERZ99371.1 - 0.0068 15.5 0.4 1.8 7.6 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.1 ERZ99371.1 - 0.0076 15.7 0.0 0.78 9.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.1 ERZ99371.1 - 0.012 15.9 0.3 1.1 9.5 0.0 3.0 3 1 0 3 3 3 0 AAA domain NB-ARC PF00931.17 ERZ99371.1 - 0.014 14.2 0.1 1.2 7.8 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.1 ERZ99371.1 - 0.015 14.8 0.2 0.33 10.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ERZ99371.1 - 0.016 14.7 0.0 0.89 9.0 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain KAP_NTPase PF07693.9 ERZ99371.1 - 0.03 13.3 0.2 7.7 5.4 0.0 2.8 2 1 0 3 3 3 0 KAP family P-loop domain AAA_11 PF13086.1 ERZ99371.1 - 0.076 12.5 0.0 2.5 7.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 ERZ99371.1 - 0.087 11.6 0.0 0.85 8.4 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.20 ERZ99371.1 - 0.088 12.2 0.0 0.57 9.6 0.0 2.1 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SRP54 PF00448.17 ERZ99371.1 - 0.13 11.6 0.5 6.7 6.1 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.4 ERZ99371.1 - 0.13 11.7 0.1 14 5.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation BatA PF07584.6 ERZ99372.1 - 0.37 11.0 1.7 18 5.5 0.1 2.6 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal LSM PF01423.17 ERZ99373.1 - 4.5e-15 54.9 0.4 5.6e-15 54.6 0.3 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ERZ99373.1 - 0.0064 16.3 0.1 0.014 15.3 0.1 1.6 1 1 0 1 1 1 1 Ataxin 2 SM domain Tail_tube PF10618.4 ERZ99373.1 - 0.057 13.1 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Phage tail tube protein CDP-OH_P_transf PF01066.16 ERZ99374.1 - 1.3e-16 60.7 9.1 2.7e-16 59.6 6.1 1.8 1 1 1 2 2 2 1 CDP-alcohol phosphatidyltransferase DNA_methylase PF00145.12 ERZ99375.1 - 2.1e-08 33.6 0.0 2.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase DUF1542 PF07564.6 ERZ99376.1 - 0.0015 18.5 3.1 0.0015 18.5 2.1 2.1 1 1 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ERZ99376.1 - 0.028 14.1 0.8 0.03 14.0 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 Baculo_VP91_N PF08475.5 ERZ99376.1 - 0.051 12.9 0.3 0.054 12.8 0.2 1.1 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal CENP-B_N PF04218.8 ERZ99376.1 - 0.089 12.2 1.4 1.1 8.7 0.3 2.2 2 1 0 2 2 2 0 CENP-B N-terminal DNA-binding domain DUF3626 PF12294.3 ERZ99376.1 - 0.099 11.6 0.1 0.11 11.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) DUF3896 PF13035.1 ERZ99376.1 - 0.15 12.0 0.8 0.24 11.4 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) DAO PF01266.19 ERZ99377.1 - 4.2e-16 58.7 0.0 5.3e-15 55.1 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ERZ99377.1 - 0.0026 17.7 0.0 0.0067 16.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ERZ99377.1 - 0.042 12.9 0.0 0.085 11.9 0.0 1.5 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.1 ERZ99377.1 - 0.044 13.5 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 ERZ99377.1 - 0.074 13.4 0.1 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ERZ99377.1 - 0.096 11.5 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.1 ERZ99377.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase_Tyr PF07714.12 ERZ99378.1 - 2.6e-06 26.7 1.0 0.075 12.0 0.0 3.1 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ99378.1 - 0.00046 19.4 4.0 0.00051 19.2 0.1 2.3 2 1 1 3 3 3 1 Protein kinase domain APH PF01636.18 ERZ99378.1 - 0.00082 19.1 0.3 0.0015 18.3 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Imm38 PF15599.1 ERZ99379.1 - 1.8 8.1 3.7 1.5 8.3 0.1 2.3 2 1 1 3 3 3 0 Immunity protein 38 CASP_C PF08172.7 ERZ99380.1 - 0.00016 20.7 7.2 0.00022 20.3 5.0 1.1 1 0 0 1 1 1 1 CASP C terminal Cep57_CLD_2 PF14197.1 ERZ99380.1 - 0.0022 17.9 7.1 0.0022 17.9 4.9 1.6 2 0 0 2 2 1 1 Centrosome localisation domain of PPC89 Sen15 PF09631.5 ERZ99380.1 - 0.012 15.8 0.3 0.017 15.3 0.2 1.1 1 0 0 1 1 1 0 Sen15 protein TSC22 PF01166.13 ERZ99380.1 - 0.089 12.7 4.2 0.21 11.5 2.2 2.2 1 1 1 2 2 2 0 TSC-22/dip/bun family MEDS PF14417.1 ERZ99380.1 - 0.11 11.5 1.3 0.16 11.0 0.9 1.3 1 1 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Nup54 PF13874.1 ERZ99380.1 - 0.15 11.7 4.2 0.078 12.6 1.2 1.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF1875 PF08961.5 ERZ99380.1 - 0.61 9.3 7.3 0.21 10.8 3.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1875) DUF972 PF06156.8 ERZ99380.1 - 1.1 9.6 11.1 16 5.9 7.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ERZ99380.1 - 1.7 8.9 15.6 2.2 8.6 4.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF904) HALZ PF02183.13 ERZ99380.1 - 3.1 7.5 10.2 10 5.9 2.3 3.2 1 1 1 3 3 3 0 Homeobox associated leucine zipper DivIC PF04977.10 ERZ99380.1 - 3.3 7.2 13.0 0.71 9.4 5.3 2.5 1 1 1 2 2 2 0 Septum formation initiator IncA PF04156.9 ERZ99380.1 - 3.7 7.0 13.2 7 6.1 9.2 1.4 1 1 0 1 1 1 0 IncA protein DUF2205 PF10224.4 ERZ99380.1 - 5 6.7 9.5 1.4 8.5 3.1 2.7 2 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) NYD-SP28_assoc PF14775.1 ERZ99380.1 - 7.1 6.4 8.4 21 4.9 0.0 3.1 1 1 2 3 3 3 0 Sperm tail C-terminal domain Dimer_Tnp_hAT PF05699.9 ERZ99381.1 - 2.2e-17 62.4 0.1 2.6e-17 62.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ERZ99382.1 - 0.00011 21.3 0.1 0.00013 21.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99382.1 - 0.00032 19.9 0.0 0.00045 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Tantalus PF15386.1 ERZ99383.1 - 0.3 10.8 3.8 1.6 8.5 2.5 2.2 1 1 1 2 2 2 0 Drosophila Tantalus-like DUF1914 PF08932.5 ERZ99384.1 - 0.043 13.8 0.0 0.074 13.0 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1914) Pput2613-deam PF14427.1 ERZ99386.1 - 0.077 12.6 0.0 0.089 12.4 0.0 1.1 1 0 0 1 1 1 0 Pput_2613-like deaminase ABC_membrane PF00664.18 ERZ99387.1 - 8.3e-109 363.2 46.5 1.9e-58 198.0 16.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ERZ99387.1 - 7.3e-72 240.0 0.2 1.7e-34 119.0 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ERZ99387.1 - 2.1e-14 53.2 7.8 1.6e-05 24.2 0.0 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ERZ99387.1 - 4.2e-08 33.4 20.0 0.0031 17.5 0.0 6.1 4 2 1 6 6 5 3 AAA domain AAA_29 PF13555.1 ERZ99387.1 - 3.5e-07 29.6 2.4 0.0027 17.1 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ERZ99387.1 - 5e-07 29.0 0.0 0.02 14.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ERZ99387.1 - 1.7e-05 25.6 0.0 0.41 11.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.4 ERZ99387.1 - 1.8e-05 23.5 1.7 0.0026 16.4 0.0 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.24 ERZ99387.1 - 3e-05 24.2 5.8 5.5 7.1 1.0 4.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ99387.1 - 3.4e-05 23.9 2.4 0.5 10.5 0.1 3.8 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ERZ99387.1 - 4.2e-05 23.5 4.6 0.048 13.6 0.1 3.3 2 2 0 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.1 ERZ99387.1 - 9.2e-05 22.2 3.7 0.08 12.8 0.1 3.8 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 ERZ99387.1 - 9.9e-05 21.8 0.1 0.71 9.2 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 ERZ99387.1 - 0.00042 19.9 1.0 0.54 9.8 0.0 3.7 2 2 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ERZ99387.1 - 0.0011 18.9 0.0 0.77 9.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ERZ99387.1 - 0.0016 18.7 0.3 2.2 8.5 0.0 3.4 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.9 ERZ99387.1 - 0.0017 18.1 1.0 3.3 7.4 0.0 3.7 4 1 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ERZ99387.1 - 0.0058 16.3 0.0 3 7.6 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain Dala_Dala_lig_N PF01820.16 ERZ99387.1 - 0.013 15.7 0.4 0.053 13.8 0.0 2.2 2 0 0 2 2 1 0 D-ala D-ala ligase N-terminus MobB PF03205.9 ERZ99387.1 - 0.014 15.0 0.5 1.6 8.4 0.1 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 ERZ99387.1 - 0.02 13.9 0.3 9.6 5.2 0.0 3.2 3 0 0 3 3 3 0 Zeta toxin DUF87 PF01935.12 ERZ99387.1 - 0.025 14.3 3.8 0.69 9.6 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 ERZ99387.1 - 0.12 11.8 0.7 0.22 10.9 0.0 1.8 2 0 0 2 2 1 0 FtsK/SpoIIIE family AAA_10 PF12846.2 ERZ99387.1 - 0.26 10.6 7.2 12 5.2 0.0 3.9 4 0 0 4 4 4 0 AAA-like domain AAA_23 PF13476.1 ERZ99387.1 - 0.45 10.8 13.2 0.42 10.9 0.0 4.1 5 0 0 5 5 3 0 AAA domain Ion_trans PF00520.26 ERZ99388.1 - 1.9e-20 72.9 15.0 2.8e-20 72.4 10.4 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 ERZ99388.1 - 6.8e-13 48.1 7.0 6.8e-13 48.1 4.9 1.9 2 0 0 2 2 2 1 Ion channel Tetraspannin PF00335.15 ERZ99388.1 - 0.0027 17.0 4.8 0.24 10.6 0.1 2.5 2 1 0 2 2 2 2 Tetraspanin family DUF2937 PF11157.3 ERZ99388.1 - 0.14 11.4 0.1 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) PhoU PF01895.14 ERZ99388.1 - 1.9 8.9 5.7 10 6.6 0.0 3.1 2 1 1 3 3 3 0 PhoU domain VIT1 PF01988.14 ERZ99389.1 - 7.7e-45 152.9 0.0 9.1e-45 152.7 0.0 1.0 1 0 0 1 1 1 1 VIT family p450 PF00067.17 ERZ99390.1 - 8.8e-08 31.0 0.0 1e-07 30.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ99391.1 - 4.2e-68 229.9 0.9 8.1e-54 182.8 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Aminotran_5 PF00266.14 ERZ99392.1 - 2.2e-25 89.1 0.0 1.4e-16 60.2 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V MOSC_N PF03476.11 ERZ99392.1 - 1e-22 80.0 0.0 1.9e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 ERZ99392.1 - 1.2e-18 66.8 0.0 3.3e-18 65.4 0.0 1.6 2 0 0 2 2 2 1 MOSC domain Mito_carr PF00153.22 ERZ99393.1 - 1.1e-78 259.0 0.3 1.1e-26 92.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fer4 PF00037.22 ERZ99394.1 - 5.2e-15 54.3 16.0 7.9e-09 34.7 3.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 ERZ99394.1 - 7e-12 45.5 10.0 1e-11 44.9 6.9 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.1 ERZ99394.1 - 1.2e-10 41.9 5.1 1.8e-05 25.4 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.1 ERZ99394.1 - 4e-10 39.5 19.0 3.9e-07 29.9 7.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 ERZ99394.1 - 7.4e-10 38.1 14.7 4.4e-05 23.1 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.1 ERZ99394.1 - 2.1e-09 37.0 10.0 6.2e-09 35.5 7.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 ERZ99394.1 - 4.1e-09 36.5 10.0 1.1e-08 35.2 7.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 ERZ99394.1 - 7.2e-08 32.1 11.6 0.00045 20.0 1.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 ERZ99394.1 - 8.8e-08 31.6 17.0 0.00035 20.3 3.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.2 ERZ99394.1 - 3e-07 30.2 8.9 0.00033 20.7 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 ERZ99394.1 - 1.4e-06 28.5 28.2 0.00017 21.8 7.2 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.1 ERZ99394.1 - 9.2e-06 25.9 10.2 0.0063 16.9 0.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 ERZ99394.1 - 0.0003 21.1 12.8 0.093 13.1 1.8 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_15 PF13459.1 ERZ99394.1 - 0.0057 17.2 12.7 0.39 11.3 0.9 2.7 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_3 PF12798.2 ERZ99394.1 - 0.013 15.9 18.2 0.039 14.5 3.2 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 ERZ99394.1 - 0.55 10.3 5.3 2.7 8.1 0.1 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain RrnaAD PF00398.15 ERZ99395.1 - 1.4e-59 201.2 0.1 1.8e-59 200.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 ERZ99395.1 - 2.7e-10 40.3 0.0 4.3e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ99395.1 - 4.4e-06 27.2 0.0 8.4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ERZ99395.1 - 1.8e-05 24.4 0.0 3.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 ERZ99395.1 - 0.00019 21.0 0.0 0.00084 18.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.13 ERZ99395.1 - 0.00048 19.3 0.0 0.00084 18.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase MTS PF05175.9 ERZ99395.1 - 0.00072 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 ERZ99395.1 - 0.0035 17.0 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ERZ99395.1 - 0.0059 17.0 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ERZ99395.1 - 0.015 14.3 0.0 0.03 13.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_28 PF02636.12 ERZ99395.1 - 0.047 13.0 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ras PF00071.17 ERZ99396.1 - 2.1e-18 66.2 0.0 1.7e-16 60.0 0.0 2.2 2 0 0 2 2 2 1 Ras family Miro PF08477.8 ERZ99396.1 - 2.1e-13 50.7 0.0 3e-12 47.0 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 ERZ99396.1 - 2e-07 30.9 0.0 4.4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 ERZ99396.1 - 2.1e-07 30.3 0.1 6.1e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ERZ99396.1 - 5e-05 22.5 0.0 8.1e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.24 ERZ99396.1 - 0.0078 16.4 0.0 0.029 14.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 ERZ99396.1 - 0.0089 15.4 0.0 0.018 14.5 0.0 1.5 2 0 0 2 2 2 1 AAA-like domain AAA_24 PF13479.1 ERZ99396.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 ERZ99396.1 - 0.023 14.1 1.9 7.8 5.8 1.2 3.3 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ERZ99396.1 - 0.027 13.6 0.0 0.049 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 ERZ99396.1 - 0.027 14.4 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.5 ERZ99396.1 - 0.029 13.5 0.0 0.07 12.3 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 ERZ99396.1 - 0.032 14.3 0.0 0.12 12.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.1 ERZ99396.1 - 0.033 14.5 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 ERZ99396.1 - 0.06 12.6 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_5 PF07728.9 ERZ99396.1 - 0.06 13.0 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Septin PF00735.13 ERZ99396.1 - 0.062 12.3 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Septin MCM PF00493.18 ERZ99396.1 - 0.078 11.7 0.4 0.22 10.3 0.0 1.9 2 1 1 3 3 3 0 MCM2/3/5 family NACHT PF05729.7 ERZ99396.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 ERZ99396.1 - 0.15 11.8 0.1 0.28 10.8 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Auxin_repressed PF05564.7 ERZ99397.1 - 0.88 10.1 3.3 1.2 9.7 0.7 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein FAD_binding_1 PF00667.15 ERZ99398.1 - 2.4e-45 154.6 0.0 4e-45 153.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 ERZ99398.1 - 1.7e-29 102.6 0.0 9.8e-29 100.1 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.16 ERZ99398.1 - 2.6e-20 73.0 0.0 2e-19 70.1 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.2 ERZ99398.1 - 0.00031 20.2 0.0 0.00067 19.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_NdrI PF07972.6 ERZ99398.1 - 0.00082 19.2 0.1 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 NrdI Flavodoxin like Flavodoxin_5 PF12724.2 ERZ99398.1 - 0.053 13.5 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Flavodoxin domain GRAM PF02893.15 ERZ99399.1 - 1e-26 92.2 3.2 3.8e-14 51.9 0.2 3.4 3 0 0 3 3 3 2 GRAM domain Glyco_transf_28 PF03033.15 ERZ99399.1 - 6.6e-25 87.4 0.0 1.3e-24 86.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.24 ERZ99399.1 - 2.7e-12 46.7 4.5 5.2e-11 42.6 0.1 4.4 5 1 0 5 5 5 1 PH domain UDPGT PF00201.13 ERZ99399.1 - 5.5e-08 31.8 0.0 1e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_3 PF14593.1 ERZ99399.1 - 1.8e-07 31.0 0.3 4.8e-07 29.6 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ERZ99399.1 - 0.0051 17.0 2.0 0.17 12.1 1.4 3.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 ERZ99399.1 - 0.031 14.3 0.0 0.12 12.4 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.1 ERZ99399.1 - 0.038 14.0 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain TIP41 PF04176.8 ERZ99400.1 - 2e-66 222.7 2.5 2e-66 222.7 1.8 1.8 2 0 0 2 2 2 1 TIP41-like family Lambda_Bor PF06291.6 ERZ99401.1 - 0.047 13.6 0.3 0.17 11.8 0.0 1.8 1 1 1 2 2 2 0 Bor protein Microtub_assoc PF07989.6 ERZ99402.1 - 2.3e-21 75.4 8.8 2.3e-21 75.4 6.1 8.5 5 3 6 12 12 12 2 Microtubule associated IncA PF04156.9 ERZ99402.1 - 0.37 10.3 123.9 0.37 10.3 14.5 6.6 2 1 5 7 7 7 0 IncA protein Reo_sigmaC PF04582.7 ERZ99402.1 - 2.6 7.1 41.0 0.087 11.9 1.2 6.1 1 1 4 6 6 6 0 Reovirus sigma C capsid protein BTB PF00651.26 ERZ99403.1 - 3.7e-13 49.4 0.1 8.7e-13 48.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99403.1 - 4.2e-13 49.4 0.7 4.2e-13 49.4 0.5 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99403.1 - 1.3e-06 28.1 3.2 2.5e-06 27.2 0.2 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch Bromodomain PF00439.20 ERZ99404.1 - 1.9e-07 30.8 0.0 4e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.20 ERZ99405.1 - 4.9e-06 26.3 0.0 7.9e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 Bromodomain Chorismate_synt PF01264.16 ERZ99407.1 - 5.7e-136 452.5 0.0 6.7e-136 452.3 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase HMG_box PF00505.14 ERZ99408.1 - 1e-23 83.3 4.6 1.8e-23 82.5 3.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99408.1 - 4.8e-16 58.8 3.8 4.8e-16 58.8 2.6 1.7 1 1 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 ERZ99408.1 - 1.3e-07 31.2 5.9 1.3e-07 31.2 4.1 2.1 1 1 1 2 2 2 1 HMG (high mobility group) box 5 YoqO PF14037.1 ERZ99409.1 - 0.082 13.0 1.4 1.6 8.8 0.9 2.2 2 1 0 2 2 2 0 YoqO-like protein 2TM PF13239.1 ERZ99409.1 - 0.11 12.5 0.7 0.17 11.9 0.5 1.3 1 0 0 1 1 1 0 2TM domain Hid1 PF12722.2 ERZ99411.1 - 8 3.9 12.9 11 3.6 8.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDRT4 PF15213.1 ERZ99412.1 - 0.079 13.0 0.3 0.09 12.8 0.2 1.1 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Pkinase_Tyr PF07714.12 ERZ99414.1 - 3.2e-38 131.2 0.0 7.7e-38 130.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99414.1 - 1.6e-30 106.1 0.3 1.1e-29 103.3 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ERZ99414.1 - 0.03 13.3 0.1 0.071 12.1 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BTB PF00651.26 ERZ99415.1 - 5.7e-17 61.7 0.1 1.5e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99415.1 - 4.4e-09 36.4 1.3 4.4e-09 36.4 0.9 1.9 2 0 0 2 2 2 1 TLD DUF577 PF04510.7 ERZ99415.1 - 0.31 10.7 4.1 1.7 8.2 0.2 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF577) Gp_UL130 PF11668.3 ERZ99416.1 - 0.065 12.7 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 HCMV glycoprotein pUL130 Pkinase_Tyr PF07714.12 ERZ99419.1 - 4.4e-36 124.2 0.0 5.7e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99419.1 - 2.6e-27 95.6 0.0 4e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ThiF PF00899.16 ERZ99421.1 - 1.2 8.9 6.6 0.31 10.8 0.4 2.8 3 0 0 3 3 3 0 ThiF family Rad60-SLD PF11976.3 ERZ99422.1 - 9.9e-25 86.0 0.1 1.2e-24 85.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ERZ99422.1 - 1.2e-10 40.5 0.1 1.5e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family CBFD_NFYB_HMF PF00808.18 ERZ99424.1 - 3.6e-10 39.7 0.1 4.8e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ERZ99424.1 - 0.01 15.9 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.9 ERZ99424.1 - 0.029 14.1 0.1 0.038 13.7 0.0 1.1 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TFIID_20kDa PF03847.8 ERZ99424.1 - 0.032 14.4 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.8 ERZ99424.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated DUF4261 PF14080.1 ERZ99425.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) BTB PF00651.26 ERZ99426.1 - 1.7e-12 47.2 0.2 4e-12 46.1 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ99426.1 - 6.3e-07 29.1 0.2 6.3e-06 25.9 0.0 2.7 2 1 0 2 2 2 1 BTB And C-terminal Kelch UPF0047 PF01894.12 ERZ99428.1 - 7.6e-43 145.0 0.0 8.7e-43 144.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 IBR PF01485.16 ERZ99429.1 - 1.7e-15 56.5 33.2 3.4e-08 33.2 5.8 3.9 3 1 1 4 4 4 3 IBR domain zf-C3HC4 PF00097.20 ERZ99429.1 - 0.016 14.8 5.2 0.016 14.8 3.6 4.8 4 2 1 5 5 5 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ERZ99429.1 - 0.024 14.4 4.3 0.024 14.4 3.0 3.9 2 1 1 3 3 3 0 Ring finger domain DUF4348 PF14254.1 ERZ99430.1 - 0.037 13.1 0.2 0.045 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4348) TRP PF06011.7 ERZ99431.1 - 1.5e-40 139.0 23.6 1.5e-28 99.5 8.2 2.6 2 1 1 3 3 3 2 Transient receptor potential (TRP) ion channel F-box-like PF12937.2 ERZ99432.1 - 0.00086 18.9 0.3 0.0022 17.6 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ERZ99432.1 - 1.2 8.9 6.3 20 5.0 2.7 3.6 2 1 0 2 2 2 0 Leucine rich repeat RRM_1 PF00076.17 ERZ99433.1 - 4.5e-81 266.4 7.0 7.7e-21 73.5 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ERZ99433.1 - 2.2e-55 184.5 2.6 6.9e-14 51.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ERZ99433.1 - 2e-45 152.4 1.6 5e-11 42.2 0.1 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 ERZ99433.1 - 1.7e-29 101.2 0.1 1.2e-28 98.5 0.1 2.5 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.1 ERZ99433.1 - 4.3e-05 23.1 0.3 4.4 7.1 0.0 4.3 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 ERZ99433.1 - 9.6e-05 22.0 1.5 1.3 8.8 0.1 4.0 4 0 0 4 4 4 2 Limkain b1 OB_RNB PF08206.6 ERZ99433.1 - 0.00099 18.5 1.1 2.8 7.5 0.0 3.4 3 0 0 3 3 3 2 Ribonuclease B OB domain YflT PF11181.3 ERZ99433.1 - 0.035 14.2 10.1 0.89 9.7 2.1 3.7 4 0 0 4 4 4 0 Heat induced stress protein YflT CSD PF00313.17 ERZ99433.1 - 0.037 13.8 1.5 10 6.0 0.1 3.5 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain PNPase PF03726.9 ERZ99433.1 - 0.052 13.8 4.5 0.13 12.5 0.1 2.8 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain CbiG_mid PF11761.3 ERZ99433.1 - 0.053 13.7 0.0 18 5.6 0.0 2.9 2 0 0 2 2 2 0 Cobalamin biosynthesis central region Nab6_mRNP_bdg PF10567.4 ERZ99433.1 - 3.6 6.4 8.9 6.3 5.6 0.1 3.2 3 0 0 3 3 3 0 RNA-recognition motif IncA PF04156.9 ERZ99434.1 - 0.0082 15.7 10.1 0.014 14.9 7.0 1.3 1 0 0 1 1 1 1 IncA protein Tropomyosin PF00261.15 ERZ99434.1 - 0.026 13.5 0.1 0.05 12.6 0.1 1.3 1 0 0 1 1 1 0 Tropomyosin NPV_P10 PF05531.7 ERZ99434.1 - 0.063 13.5 4.3 0.48 10.7 3.0 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.4 ERZ99434.1 - 0.17 12.0 5.3 0.28 11.3 0.4 2.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.6 ERZ99434.1 - 0.19 11.5 10.8 0.48 10.2 7.5 1.7 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DASH_Dad3 PF08656.5 ERZ99434.1 - 0.36 10.5 5.0 9.5 5.9 3.3 2.7 1 1 1 2 2 2 0 DASH complex subunit Dad3 DUF972 PF06156.8 ERZ99434.1 - 1.2 9.4 8.3 8.1 6.8 4.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Pkinase_Tyr PF07714.12 ERZ99436.1 - 1.8e-48 164.9 0.1 2.5e-48 164.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99436.1 - 7.7e-44 149.7 2.1 1.4e-43 148.8 1.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ99436.1 - 3.7e-13 49.6 1.9 1.7e-05 25.2 0.1 2.6 2 0 0 2 2 2 2 Sel1 repeat Kelch_3 PF13415.1 ERZ99437.1 - 3.9e-06 26.8 0.5 0.5 10.5 0.0 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ERZ99437.1 - 6.1e-06 25.9 1.6 0.54 10.0 0.0 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain DUF2273 PF10031.4 ERZ99437.1 - 0.022 14.3 0.4 0.039 13.5 0.3 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) Kelch_5 PF13854.1 ERZ99437.1 - 0.095 12.6 6.5 23 5.0 0.0 4.2 4 0 0 4 4 4 0 Kelch motif Calici_PP_N PF08405.6 ERZ99437.1 - 0.098 11.4 0.1 1.2 7.8 0.1 2.0 1 1 1 2 2 2 0 Viral polyprotein N-terminal Kelch_6 PF13964.1 ERZ99437.1 - 0.33 11.1 2.8 20 5.5 0.0 3.7 3 1 1 4 4 4 0 Kelch motif Kelch_2 PF07646.10 ERZ99437.1 - 0.69 9.7 4.3 35 4.3 0.1 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.20 ERZ99437.1 - 0.88 9.1 5.7 22 4.7 0.0 4.0 4 0 0 4 4 4 0 Kelch motif RNase_H PF00075.19 ERZ99438.1 - 0.0014 18.9 0.0 0.0023 18.2 0.0 1.3 1 0 0 1 1 1 1 RNase H Pkinase_Tyr PF07714.12 ERZ99439.1 - 6.4e-28 97.5 0.0 7.3e-28 97.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99439.1 - 2.2e-26 92.5 0.0 2.5e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ99439.1 - 0.045 13.4 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsbU PF06514.6 ERZ99439.1 - 0.11 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) RIO1 PF01163.17 ERZ99439.1 - 0.14 11.4 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 RIO1 family MIR PF02815.14 ERZ99441.1 - 2.8e-09 36.7 1.8 3.3e-07 30.0 0.6 2.8 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ERZ99441.1 - 0.00023 20.2 0.0 0.00069 18.7 0.0 1.7 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DHC_N1 PF08385.7 ERZ99442.1 - 1.3e-85 288.0 6.2 1.9e-85 287.4 4.3 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Hrs_helical PF12210.3 ERZ99442.1 - 0.047 13.9 0.4 0.37 11.0 0.1 2.7 3 0 0 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF4163 PF13739.1 ERZ99442.1 - 0.16 12.7 4.3 0.28 11.9 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4163) PQQ PF01011.16 ERZ99443.1 - 3.6e-06 26.2 0.4 0.1 12.1 0.0 2.6 2 0 0 2 2 2 2 PQQ enzyme repeat PQQ_2 PF13360.1 ERZ99443.1 - 0.055 12.9 0.1 0.26 10.7 0.1 1.8 1 1 0 1 1 1 0 PQQ-like domain DUF1903 PF08991.5 ERZ99443.1 - 0.073 13.2 0.2 0.12 12.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) HPIP PF15226.1 ERZ99445.1 - 0.053 13.5 0.0 0.077 13.0 0.0 1.3 1 1 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family DUF4367 PF14285.1 ERZ99446.1 - 0.093 12.0 1.3 0.11 11.7 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Acetyltransf_7 PF13508.1 ERZ99449.1 - 3e-06 27.2 0.0 1.7e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ERZ99449.1 - 5.8e-06 26.1 0.0 1.3e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ERZ99449.1 - 0.0054 16.7 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family NMD3 PF04981.8 ERZ99450.1 - 9.5e-78 260.5 5.6 1.5e-77 259.9 3.8 1.3 1 0 0 1 1 1 1 NMD3 family DUF1180 PF06679.7 ERZ99450.1 - 0.044 13.6 0.8 0.088 12.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) HEAT PF02985.17 ERZ99451.1 - 6.7e-21 72.4 6.3 3.3e-06 26.6 0.0 8.5 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.1 ERZ99451.1 - 8.4e-19 67.6 5.8 8.7e-09 35.5 0.1 4.5 3 1 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.1 ERZ99451.1 - 2.3e-18 66.0 4.6 1.4e-07 31.7 0.0 7.5 6 2 2 8 8 8 4 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ERZ99451.1 - 7e-12 45.5 0.8 0.00029 21.1 0.0 6.0 5 2 3 8 8 8 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.7 ERZ99451.1 - 3.8e-06 26.6 1.6 0.033 13.8 0.0 4.0 4 1 0 5 5 5 2 rRNA processing/ribosome biogenesis Arm PF00514.18 ERZ99451.1 - 1.5e-05 24.5 0.0 9.1 6.2 0.0 5.2 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 ERZ99451.1 - 4.2e-05 22.0 4.0 0.00017 20.0 0.1 2.9 2 1 0 2 2 2 1 Adaptin N terminal region DNA_alkylation PF08713.6 ERZ99451.1 - 0.0018 17.8 0.0 0.019 14.4 0.0 2.4 2 0 0 2 2 2 1 DNA alkylation repair enzyme DUF3385 PF11865.3 ERZ99451.1 - 0.26 11.2 2.7 8.8 6.2 0.0 4.2 5 1 0 5 5 5 0 Domain of unknown function (DUF3385) Kelch_4 PF13418.1 ERZ99452.1 - 1.1e-13 50.7 15.1 0.0019 17.9 0.2 5.7 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ99452.1 - 1.7e-08 34.3 10.6 0.89 9.8 0.0 7.0 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ERZ99452.1 - 5.3e-08 32.3 6.6 0.0051 16.5 0.0 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.20 ERZ99452.1 - 1.2e-06 27.9 9.3 0.02 14.4 0.0 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.1 ERZ99452.1 - 4.2e-06 26.7 13.4 0.34 11.1 0.1 6.1 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 ERZ99452.1 - 0.0011 18.8 21.0 0.94 9.5 0.0 6.0 6 0 0 6 6 6 3 Kelch motif DUF327 PF03885.8 ERZ99452.1 - 0.64 9.8 7.8 1 9.1 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF327) DUF4337 PF14235.1 ERZ99453.1 - 0.031 14.0 0.3 0.051 13.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Laminin_G_3 PF13385.1 ERZ99454.1 - 1.8e-17 64.0 0.0 2.2e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily VASP_tetra PF08776.6 ERZ99456.1 - 0.0037 16.5 5.4 0.024 13.9 1.1 2.7 3 0 0 3 3 3 1 VASP tetramerisation domain Tctex-1 PF03645.8 ERZ99456.1 - 0.029 14.1 1.9 0.045 13.5 1.3 1.3 1 0 0 1 1 1 0 Tctex-1 family Antig_Caf1 PF09255.5 ERZ99456.1 - 0.063 13.1 0.2 0.095 12.5 0.1 1.3 1 0 0 1 1 1 0 Caf1 Capsule antigen DUF4186 PF13811.1 ERZ99456.1 - 0.14 11.8 0.3 0.27 10.9 0.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) Methyltransf_5 PF01795.14 ERZ99457.1 - 0.031 13.5 0.1 0.04 13.2 0.1 1.1 1 0 0 1 1 1 0 MraW methylase family XH PF03469.9 ERZ99457.1 - 0.061 12.9 0.5 0.068 12.8 0.3 1.1 1 0 0 1 1 1 0 XH domain HTH_40 PF14493.1 ERZ99457.1 - 0.088 13.0 0.2 0.11 12.7 0.1 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain DUF892 PF05974.7 ERZ99457.1 - 0.096 12.4 0.0 0.096 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF892) Motilin_ghrelin PF04644.7 ERZ99457.1 - 0.11 12.3 1.3 0.3 10.9 0.9 1.7 1 0 0 1 1 1 0 Motilin/ghrelin FixQ PF05545.6 ERZ99459.1 - 0.091 12.4 0.9 0.25 11.0 0.2 2.0 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ RHSP PF07999.6 ERZ99461.1 - 0.052 12.1 4.3 0.22 10.0 0.4 2.6 1 1 0 2 2 2 0 Retrotransposon hot spot protein DUF2457 PF10446.4 ERZ99461.1 - 7.5 5.1 9.3 12 4.5 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BTB PF00651.26 ERZ99463.1 - 1.1e-16 60.7 0.0 2.4e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99463.1 - 1.7e-13 50.7 1.3 4.3e-13 49.4 0.6 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99463.1 - 2.1e-07 30.7 2.9 1.6e-06 27.8 0.5 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch EppA_BapA PF07268.6 ERZ99463.1 - 0.17 11.5 2.3 0.39 10.3 0.2 2.7 3 1 0 3 3 3 0 Exported protein precursor (EppA/BapA) HMG_box PF00505.14 ERZ99464.1 - 6.5e-08 32.7 1.3 1.5e-07 31.6 0.9 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99464.1 - 0.0032 17.8 0.5 0.0056 17.0 0.4 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ERZ99465.1 - 6.1e-06 26.4 1.4 1.3e-05 25.4 1.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99465.1 - 0.0032 17.7 1.0 0.0059 16.9 0.7 1.4 1 0 0 1 1 1 1 HMG-box domain Glyco_transf_22 PF03901.12 ERZ99466.1 - 1.3e-51 175.9 27.9 2e-51 175.3 19.3 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family F-box-like PF12937.2 ERZ99469.1 - 7.2e-06 25.6 1.5 1.4e-05 24.6 1.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ERZ99469.1 - 0.0073 15.9 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 F-box domain BID PF06393.6 ERZ99471.1 - 0.076 12.3 0.2 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 BH3 interacting domain (BID) Myb_DNA-bind_3 PF12776.2 ERZ99471.1 - 0.58 10.8 4.9 3.4 8.3 0.5 2.2 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Bromodomain PF00439.20 ERZ99472.1 - 1.8e-17 63.0 1.5 2.4e-17 62.6 1.1 1.2 1 0 0 1 1 1 1 Bromodomain Chordopox_RPO7 PF05864.7 ERZ99474.1 - 0.057 13.5 0.4 0.078 13.0 0.3 1.2 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Pox_A22 PF04848.8 ERZ99475.1 - 0.2 11.5 2.7 0.43 10.4 1.1 1.8 1 1 1 2 2 2 0 Poxvirus A22 protein DUF2362 PF10154.4 ERZ99476.1 - 1.3e-08 33.9 3.0 1.6e-08 33.7 2.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) DUF3150 PF11348.3 ERZ99476.1 - 0.0011 18.1 3.8 0.16 11.0 0.2 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3150) DUF2192 PF09958.4 ERZ99476.1 - 0.098 11.8 1.3 0.13 11.4 0.1 1.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) Zwint PF15556.1 ERZ99476.1 - 0.11 11.6 6.5 0.063 12.5 3.2 1.4 1 1 0 1 1 1 0 ZW10 interactor Arc_PepC PF06819.6 ERZ99476.1 - 0.11 12.3 1.8 0.15 11.9 0.6 1.7 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain GrpE PF01025.14 ERZ99476.1 - 0.3 10.6 6.3 0.076 12.5 0.8 2.1 1 1 1 2 2 2 0 GrpE PKK PF12474.3 ERZ99476.1 - 5.6 6.6 13.7 0.078 12.6 1.8 2.6 2 1 1 3 3 3 0 Polo kinase kinase DUF1154 PF06631.6 ERZ99476.1 - 8 6.2 7.8 9.8 5.9 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) DUF2362 PF10154.4 ERZ99477.1 - 1.5e-66 225.1 4.4 1.1e-39 136.4 1.2 2.0 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2362) DUF2962 PF11176.3 ERZ99479.1 - 2.4e-28 98.6 12.1 4.5e-28 97.7 5.1 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF2962) Fe-S_biosyn PF01521.15 ERZ99480.1 - 3.6e-20 71.9 0.0 4.3e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Sec20 PF03908.8 ERZ99481.1 - 8.6e-25 86.2 2.4 8.6e-25 86.2 1.7 2.4 2 1 0 2 2 2 1 Sec20 ATP-synt_F PF01990.12 ERZ99481.1 - 0.047 14.0 1.4 0.11 12.8 1.0 1.6 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit DUF3325 PF11804.3 ERZ99481.1 - 0.085 12.7 0.5 0.12 12.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3325) DUF4411 PF14367.1 ERZ99481.1 - 1.1 8.9 6.1 1.8 8.2 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4411) Exonuc_VII_L PF02601.10 ERZ99481.1 - 1.6 7.8 11.4 2.2 7.3 7.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.6 ERZ99481.1 - 3.7 6.7 13.3 0.88 8.8 3.7 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Vfa1 PF08432.5 ERZ99481.1 - 4.2 7.3 8.5 5.6 6.9 5.5 1.5 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ISG65-75 PF11727.3 ERZ99481.1 - 4.9 6.1 9.7 0.87 8.5 3.5 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein CCDC-167 PF15188.1 ERZ99481.1 - 5.7 6.9 14.1 0.61 10.0 4.8 2.9 2 2 0 2 2 2 0 Coiled-coil domain-containing protein 167 Hormone_1 PF00103.15 ERZ99481.1 - 7.5 5.8 10.2 3.6 6.8 1.9 2.6 1 1 1 2 2 2 0 Somatotropin hormone family Peptidase_S46 PF10459.4 ERZ99481.1 - 8.6 4.6 9.7 15 3.8 6.4 1.4 1 1 0 1 1 1 0 Peptidase S46 Response_reg PF00072.19 ERZ99482.1 - 1.6e-21 76.3 0.0 1.5e-15 57.2 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain Kinesin PF00225.18 ERZ99484.1 - 2.1e-12 46.3 0.0 3.3e-12 45.7 0.0 1.3 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ERZ99484.1 - 0.039 12.8 0.1 0.044 12.6 0.1 1.4 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 ERZ99484.1 - 0.043 13.3 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.15 ERZ99485.1 - 7.2e-118 393.6 11.1 8.1e-118 393.4 7.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 ERZ99485.1 - 2.8e-18 65.7 1.0 4.4e-13 48.8 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 ERZ99485.1 - 0.0058 17.1 0.1 4.7 7.7 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein GTP_EFTU PF00009.22 ERZ99485.1 - 0.012 15.0 1.5 1.7 8.0 0.2 2.7 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ERZ99485.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.6 ERZ99485.1 - 0.13 11.0 0.0 0.25 10.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein PNP_UDP_1 PF01048.15 ERZ99487.1 - 5.2e-37 127.0 0.0 6.1e-37 126.8 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily CbiJ PF02571.9 ERZ99487.1 - 0.17 11.1 0.0 0.41 9.9 0.0 1.6 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK Halogen_Hydrol PF10112.4 ERZ99488.1 - 1.4 8.3 4.7 1.4 8.3 3.2 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Pkr1 PF08636.5 ERZ99488.1 - 2.2 8.4 10.4 2.1 8.4 6.7 1.4 1 1 1 2 2 2 0 ER protein Pkr1 Opy2 PF09463.5 ERZ99489.1 - 0.00027 20.9 18.6 0.0005 20.1 12.9 1.5 1 0 0 1 1 1 1 Opy2 protein ETRAMP PF09716.5 ERZ99489.1 - 0.019 14.8 0.0 0.068 13.1 0.0 1.9 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ThiF PF00899.16 ERZ99490.1 - 6.8e-22 77.7 0.0 6.1e-21 74.6 0.0 2.0 2 0 0 2 2 2 1 ThiF family Myb_DNA-bind_6 PF13921.1 ERZ99491.1 - 4.3e-13 49.1 6.6 3.6e-10 39.8 4.3 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ERZ99491.1 - 5e-12 45.6 2.1 3.5e-09 36.5 1.4 2.3 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ERZ99491.1 - 0.078 13.1 3.9 0.22 11.6 2.5 1.9 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain HTH_Tnp_Tc3_2 PF01498.13 ERZ99491.1 - 0.2 11.7 1.8 11 6.1 0.1 2.3 2 0 0 2 2 2 0 Transposase FadA PF09403.5 ERZ99492.1 - 0.41 10.6 6.0 1 9.3 4.2 1.7 1 1 0 1 1 1 0 Adhesion protein FadA Cse1 PF08506.5 ERZ99493.1 - 0.02 13.4 0.1 0.031 12.8 0.0 1.2 1 0 0 1 1 1 0 Cse1 LRR_4 PF12799.2 ERZ99494.1 - 0.0016 18.0 5.4 0.0016 18.0 3.7 4.5 3 2 1 4 4 4 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ERZ99494.1 - 0.11 12.7 4.6 8.1 7.1 0.1 4.9 4 1 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 ERZ99494.1 - 0.3 10.8 16.0 0.022 14.5 4.6 3.8 4 1 0 4 4 4 0 Leucine rich repeat Y_phosphatase2 PF03162.8 ERZ99495.1 - 4e-12 45.7 0.8 9.1e-11 41.3 0.1 2.1 2 0 0 2 2 2 2 Tyrosine phosphatase family Med18 PF09637.5 ERZ99496.1 - 4.6e-16 59.1 0.0 3.9e-12 46.2 0.0 2.3 1 1 1 2 2 2 2 Med18 protein Suc_Fer-like PF06999.7 ERZ99497.1 - 3.7e-52 177.6 1.9 1.3e-51 175.8 0.0 2.0 2 0 0 2 2 2 1 Sucrase/ferredoxin-like PRCC PF10253.4 ERZ99497.1 - 0.15 12.7 8.1 0.27 11.8 5.6 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Trypan_PARP PF05887.6 ERZ99497.1 - 0.55 10.0 7.5 0.96 9.2 5.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pex14_N PF04695.8 ERZ99497.1 - 0.94 9.5 12.8 2.1 8.4 8.9 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Neisseria_TspB PF05616.8 ERZ99497.1 - 3.7 5.8 7.1 6.1 5.0 4.9 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF605 PF04652.11 ERZ99497.1 - 6.7 5.9 16.3 9.7 5.4 11.3 1.2 1 0 0 1 1 1 0 Vta1 like RdRP PF05183.7 ERZ99499.1 - 3.4e-175 584.0 0.9 5.3e-175 583.4 0.6 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase HSP20 PF00011.16 ERZ99500.1 - 1.6e-07 31.1 0.0 1.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Cas_Csa5 PF09702.5 ERZ99500.1 - 0.013 15.6 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csa5) Spc97_Spc98 PF04130.8 ERZ99501.1 - 3.5e-134 448.0 1.5 4.6e-134 447.7 1.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Ribosomal_L4 PF00573.17 ERZ99502.1 - 1.7e-10 40.5 0.7 2.1e-10 40.3 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family PP2C PF00481.16 ERZ99506.1 - 2.7e-29 102.3 0.0 3.3e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C BCS1_N PF08740.6 ERZ99509.1 - 0.00028 20.5 0.0 0.0091 15.6 0.0 2.3 2 0 0 2 2 2 1 BCS1 N terminal Pkinase_Tyr PF07714.12 ERZ99509.1 - 0.0042 16.1 0.0 0.0071 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4413 PF14372.1 ERZ99509.1 - 0.032 14.1 4.2 1.4 8.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) DBINO PF13892.1 ERZ99510.1 - 0.017 15.1 0.7 0.028 14.4 0.5 1.4 1 0 0 1 1 1 0 DNA-binding domain EF1G PF00647.14 ERZ99512.1 - 0.026 14.2 0.5 0.042 13.5 0.1 1.5 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain DUF2222 PF09984.4 ERZ99513.1 - 0.076 12.4 0.1 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized signal transduction histidine kinase domain (DUF2222) COPIIcoated_ERV PF07970.7 ERZ99514.1 - 1e-82 277.1 1.4 1.2e-82 276.8 1.0 1.0 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter PHD PF00628.24 ERZ99516.1 - 8.8e-17 60.5 23.9 2.3e-11 43.2 6.2 2.7 2 1 1 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.1 ERZ99516.1 - 0.00076 19.5 11.4 0.0038 17.3 1.9 2.5 2 0 0 2 2 2 2 PHD-like zinc-binding domain PPR_2 PF13041.1 ERZ99517.1 - 1e-13 51.0 11.1 1.2e-06 28.3 0.6 6.0 5 1 1 6 6 6 4 PPR repeat family PPR_3 PF13812.1 ERZ99517.1 - 2.9e-06 27.0 1.1 0.87 10.0 0.0 5.1 5 0 0 5 5 5 2 Pentatricopeptide repeat domain Cullin_binding PF03556.10 ERZ99517.1 - 0.016 15.3 0.2 0.016 15.3 0.1 2.2 2 1 0 2 2 2 0 Cullin binding PPR PF01535.15 ERZ99517.1 - 0.025 14.5 21.4 0.51 10.4 0.1 6.8 8 0 0 8 8 8 0 PPR repeat PPR_1 PF12854.2 ERZ99517.1 - 2.9 7.4 13.2 3.7 7.0 0.2 5.7 7 0 0 7 7 7 0 PPR repeat Ribosomal_L35p PF01632.14 ERZ99518.1 - 2.2e-15 56.2 4.8 2.4e-15 56.1 3.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35 Toxin_23 PF08093.6 ERZ99519.1 - 0.066 13.1 0.4 0.085 12.7 0.3 1.2 1 0 0 1 1 1 0 Magi 5 toxic peptide family DUF3958 PF13125.1 ERZ99521.1 - 0.59 10.0 5.5 2.5 8.0 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) HTH_Tnp_Tc5 PF03221.11 ERZ99524.1 - 0.0043 16.8 0.0 0.0079 15.9 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MACPF PF01823.14 ERZ99525.1 - 9.2e-06 25.4 4.4 2.3e-05 24.1 3.1 1.7 1 0 0 1 1 1 1 MAC/Perforin domain ATP-synt_D PF01813.12 ERZ99529.1 - 5.7e-47 159.8 1.1 7.2e-47 159.4 0.8 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Methyltransf_16 PF10294.4 ERZ99530.1 - 4.4e-29 101.1 2.2 4.4e-29 101.1 1.6 1.6 1 1 1 2 2 2 1 Putative methyltransferase PCMT PF01135.14 ERZ99530.1 - 0.024 14.1 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.10 ERZ99530.1 - 0.046 12.8 0.3 0.087 11.9 0.2 1.5 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G MTS PF05175.9 ERZ99530.1 - 0.06 12.7 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.15 ERZ99530.1 - 0.06 12.3 0.0 0.089 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase ELMO_CED12 PF04727.8 ERZ99531.1 - 2.9e-05 23.6 0.7 0.12 11.9 0.0 2.3 1 1 1 2 2 2 2 ELMO/CED-12 family NblA PF04485.7 ERZ99532.1 - 0.052 13.4 0.3 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA FIBP PF05427.6 ERZ99532.1 - 0.099 11.8 0.0 0.13 11.5 0.0 1.0 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) DUF2121 PF09894.4 ERZ99532.1 - 0.12 11.6 0.4 0.14 11.4 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) PHA_synth_III_E PF09712.5 ERZ99532.1 - 1.1 8.5 4.1 1.3 8.3 2.9 1.1 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Pkinase_Tyr PF07714.12 ERZ99533.1 - 3.7e-20 72.0 0.0 4.6e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99533.1 - 3e-13 49.5 0.0 4.1e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ERZ99534.1 - 1.1e-24 87.0 0.0 1.2e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99534.1 - 2.6e-21 75.8 0.0 2.8e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ99534.1 - 0.0021 17.8 0.0 0.003 17.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ99534.1 - 0.032 13.2 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-NADH-PPase PF09297.6 ERZ99535.1 - 1.6 8.3 4.2 2.1 7.9 1.5 2.2 2 1 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HMG_box PF00505.14 ERZ99538.1 - 0.00011 22.4 4.0 0.00021 21.4 2.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99538.1 - 0.00037 20.8 4.7 0.00071 19.9 3.3 1.5 1 0 0 1 1 1 1 HMG-box domain DUF1021 PF06257.6 ERZ99538.1 - 0.00048 19.7 0.2 27 4.5 0.0 5.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1021) DUF1007 PF06226.8 ERZ99538.1 - 0.47 10.1 5.0 0.76 9.4 1.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1007) HEXIM PF15313.1 ERZ99538.1 - 0.55 10.4 14.3 4.5 7.4 4.3 4.1 3 2 0 4 4 4 0 Hexamethylene bis-acetamide-inducible protein Cylicin_N PF15241.1 ERZ99538.1 - 5.3 6.9 10.6 74 3.2 0.0 4.9 5 0 0 5 5 5 0 Cylicin N-terminus SOG2 PF10428.4 ERZ99539.1 - 8e-05 21.4 0.7 0.00011 21.0 0.5 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein ketoacyl-synt PF00109.21 ERZ99541.1 - 1.1e-57 195.3 1.2 1.3e-57 195.1 0.3 1.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 ERZ99541.1 - 4.2e-36 123.3 0.2 8.4e-36 122.4 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 ERZ99541.1 - 2.8e-05 23.2 0.0 7.9e-05 21.7 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ERZ99541.1 - 0.01 15.2 2.5 0.063 12.7 0.0 3.1 3 1 1 4 4 4 0 Thiolase, C-terminal domain DASH_Dad2 PF08654.5 ERZ99542.1 - 1.1e-17 63.8 1.5 1.5e-17 63.4 1.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad2 Cas_Csd1 PF09709.5 ERZ99542.1 - 0.078 11.2 1.4 0.52 8.5 0.4 1.9 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Csd1) DASH_Dad1 PF08649.5 ERZ99542.1 - 0.12 12.1 0.2 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad1 Glyco_hydro_9 PF00759.14 ERZ99542.1 - 0.16 10.8 0.4 0.17 10.7 0.3 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 Med4 PF10018.4 ERZ99542.1 - 0.46 9.8 3.3 0.65 9.3 2.3 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 dCMP_cyt_deam_1 PF00383.17 ERZ99543.1 - 1.1e-13 50.6 1.1 2.1e-13 49.7 0.7 1.5 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.1 ERZ99543.1 - 0.15 11.8 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase MACPF PF01823.14 ERZ99544.1 - 3.5e-06 26.8 4.9 3.5e-06 26.8 3.4 2.2 2 1 0 2 2 2 1 MAC/Perforin domain DUF1540 PF07561.6 ERZ99544.1 - 6.5 6.8 6.4 2.2 8.3 0.0 3.2 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1540) MACPF PF01823.14 ERZ99545.1 - 1e-05 25.3 6.7 1e-05 25.3 4.7 3.1 3 1 0 3 3 3 1 MAC/Perforin domain Pkinase PF00069.20 ERZ99547.1 - 5.8e-39 133.8 0.1 6.8e-39 133.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99547.1 - 1.4e-36 125.9 0.0 1.6e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ99547.1 - 0.00087 19.0 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ERZ99547.1 - 0.00094 18.2 0.1 0.0014 17.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ99547.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ99547.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL E1_DerP2_DerF2 PF02221.10 ERZ99548.1 - 0.024 14.9 0.1 0.08 13.1 0.0 1.8 1 1 0 1 1 1 0 ML domain BTB PF00651.26 ERZ99549.1 - 4.2e-20 71.7 0.1 8.5e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99549.1 - 7.3e-07 29.2 2.9 7.3e-07 29.2 2.0 2.8 2 2 0 2 2 2 1 TLD DUF3342 PF11822.3 ERZ99549.1 - 0.0006 19.0 0.2 0.0011 18.1 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.12 ERZ99550.1 - 8.7e-34 116.7 0.0 1e-33 116.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99550.1 - 1.3e-31 109.7 0.3 1.5e-31 109.5 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ERZ99550.1 - 2.1e-06 26.9 0.0 2.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ERZ99550.1 - 0.00038 19.5 0.0 0.00052 19.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99550.1 - 0.0026 17.5 0.1 0.0033 17.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Myb_DNA-binding PF00249.26 ERZ99553.1 - 2.8e-23 81.6 7.5 8.5e-08 32.1 0.1 3.8 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ERZ99553.1 - 1.1e-17 63.8 19.1 1.1e-12 47.8 0.9 4.5 2 2 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ERZ99553.1 - 0.0001 22.3 14.8 0.0018 18.3 2.2 3.5 3 1 1 4 4 4 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.3 ERZ99553.1 - 0.013 15.3 0.4 0.045 13.6 0.1 2.2 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain AF0941-like PF14591.1 ERZ99553.1 - 0.088 12.8 2.5 3 7.9 0.3 3.0 2 1 1 3 3 3 0 AF0941-like HD PF01966.17 ERZ99553.1 - 0.25 11.3 1.7 0.54 10.2 0.5 2.1 2 0 0 2 2 2 0 HD domain Myb_DNA-bind_5 PF13873.1 ERZ99553.1 - 3.1 7.7 8.2 1.2 9.1 0.4 3.5 4 0 0 4 4 4 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 ERZ99554.1 - 2.9e-41 141.3 2.3 3.7e-41 141.0 1.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99554.1 - 7.2e-39 133.4 0.2 8.4e-39 133.1 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ERZ99554.1 - 6e-06 25.7 1.7 1.2e-05 24.7 0.2 1.9 1 1 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ERZ99554.1 - 0.00038 19.4 0.0 0.0021 17.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ERZ99554.1 - 0.00099 18.2 0.1 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99554.1 - 0.2 11.3 0.2 0.33 10.6 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ERZ99555.1 - 4.4e-142 459.4 72.1 9.3e-13 48.3 1.6 12.3 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ERZ99555.1 - 5.4e-09 35.9 36.8 0.31 11.6 0.3 11.3 11 1 0 11 11 11 4 Tetratricopeptide repeat HTH_16 PF12645.2 ERZ99555.1 - 0.0002 21.2 16.2 16 5.5 0.0 8.3 9 0 0 9 9 9 2 Helix-turn-helix domain TPR_17 PF13431.1 ERZ99555.1 - 0.00022 21.1 40.3 10 6.6 0.0 12.9 7 3 5 13 13 13 4 Tetratricopeptide repeat MIT PF04212.13 ERZ99555.1 - 6.3 6.7 52.1 4.5 7.2 0.4 10.6 6 5 5 11 11 11 0 MIT (microtubule interacting and transport) domain DDHD PF02862.12 ERZ99557.1 - 0.018 14.8 5.4 0.02 14.6 3.8 1.1 1 0 0 1 1 1 0 DDHD domain Pex16 PF08610.5 ERZ99557.1 - 0.041 12.8 2.0 0.047 12.6 1.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) ATP11 PF06644.6 ERZ99557.1 - 0.042 13.3 7.3 0.064 12.7 5.1 1.3 1 0 0 1 1 1 0 ATP11 protein Zip PF02535.17 ERZ99557.1 - 0.12 11.3 0.7 0.11 11.4 0.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Tom37_C PF11801.3 ERZ99557.1 - 0.13 12.1 3.0 0.15 11.9 2.0 1.3 1 0 0 1 1 1 0 Tom37 C-terminal domain RP-C_C PF11800.3 ERZ99557.1 - 0.28 10.8 4.0 0.32 10.6 2.8 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Band_3_cyto PF07565.8 ERZ99557.1 - 0.33 10.4 4.0 0.37 10.2 2.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Apt1 PF10351.4 ERZ99557.1 - 0.34 9.7 9.8 0.37 9.6 6.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF1764 PF08576.5 ERZ99557.1 - 1.1 10.0 11.5 1.6 9.5 8.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) RNA_polI_A34 PF08208.6 ERZ99557.1 - 2.9 7.5 19.8 3.9 7.1 13.7 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_S49_N PF08496.5 ERZ99557.1 - 3 7.6 6.7 4.3 7.1 4.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Med19 PF10278.4 ERZ99557.1 - 5.9 6.5 15.4 8.3 6.0 10.6 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 AMP-binding PF00501.23 ERZ99558.1 - 7.3e-77 258.5 0.0 8.7e-77 258.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ERZ99558.1 - 2.8e-15 57.0 0.0 7.1e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pkinase PF00069.20 ERZ99561.1 - 1.3e-33 116.2 0.3 1.9e-33 115.7 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99561.1 - 2.6e-27 95.5 0.0 3.8e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1491 PF07372.7 ERZ99562.1 - 0.038 13.8 1.9 0.054 13.4 1.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1491) FixQ PF05545.6 ERZ99563.1 - 0.13 11.8 0.3 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ LRRC37AB_C PF14914.1 ERZ99563.1 - 0.34 10.3 1.8 0.68 9.3 0.0 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF1240 PF06836.7 ERZ99563.1 - 1.6 8.9 6.2 11 6.3 3.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1240) DNA_pol_B PF00136.16 ERZ99566.1 - 7.2e-14 51.4 0.0 2.7e-13 49.5 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase family B Hormone_2 PF00123.15 ERZ99566.1 - 0.088 12.6 1.5 5.3 6.9 0.1 2.5 2 0 0 2 2 2 0 Peptide hormone Vpu PF00558.14 ERZ99566.1 - 0.34 10.4 2.2 0.58 9.7 0.1 2.2 2 0 0 2 2 2 0 Vpu protein HPD PF05044.7 ERZ99567.1 - 0.058 13.0 0.7 0.062 12.9 0.5 1.0 1 0 0 1 1 1 0 Homeo-prospero domain HCNGP PF07818.8 ERZ99567.1 - 0.24 11.4 2.3 0.27 11.3 1.6 1.1 1 0 0 1 1 1 0 HCNGP-like protein RNase_H PF00075.19 ERZ99569.1 - 0.0015 18.8 0.2 0.0038 17.5 0.0 1.7 2 0 0 2 2 2 1 RNase H AsmA_1 PF13109.1 ERZ99569.1 - 0.043 13.0 0.5 0.078 12.2 0.3 1.4 1 0 0 1 1 1 0 AsmA-like C-terminal region Haemocyan_bet_s PF14830.1 ERZ99569.1 - 0.056 13.1 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Haemocyanin beta-sandwich AdoHcyase PF05221.12 ERZ99569.1 - 0.082 11.8 0.1 0.099 11.5 0.1 1.1 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase zinc_ribbon_2 PF13240.1 ERZ99570.1 - 0.036 13.5 0.4 0.074 12.5 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain DUF4187 PF13821.1 ERZ99570.1 - 0.077 12.5 0.4 0.13 11.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Pkinase_Tyr PF07714.12 ERZ99572.1 - 1.2e-09 37.5 0.0 1.9e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99572.1 - 5.5e-05 22.4 0.1 0.00012 21.3 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF3078 PF11276.3 ERZ99572.1 - 0.18 11.9 1.6 14 5.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3078) SWIB PF02201.13 ERZ99572.1 - 0.2 11.3 0.9 9.3 6.0 0.0 2.7 3 0 0 3 3 3 0 SWIB/MDM2 domain Strumpellin PF10266.4 ERZ99575.1 - 0.05 11.0 0.0 0.065 10.6 0.0 1.1 1 0 0 1 1 1 0 Hereditary spastic paraplegia protein strumpellin LRR_4 PF12799.2 ERZ99575.1 - 4.9 6.8 11.4 16 5.2 3.9 3.8 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Y_phosphatase3 PF13350.1 ERZ99576.1 - 7.1e-38 130.4 0.0 2.2e-37 128.8 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 ERZ99576.1 - 1.9e-07 31.0 0.0 4.5e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Y_phosphatase2 PF03162.8 ERZ99576.1 - 1.4e-05 24.5 0.1 3e-05 23.4 0.0 1.8 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ERZ99576.1 - 0.0002 20.7 0.0 0.00045 19.6 0.0 1.7 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ERZ99576.1 - 0.02 14.9 0.0 0.06 13.3 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate DSPc PF00782.15 ERZ99576.1 - 0.036 13.6 0.7 1.6 8.3 0.0 2.7 1 1 1 2 2 2 0 Dual specificity phosphatase, catalytic domain Pneumo_M2 PF07380.6 ERZ99577.1 - 0.023 14.6 0.1 0.039 13.9 0.1 1.6 1 0 0 1 1 1 0 Pneumovirus M2 protein Sel1 PF08238.7 ERZ99580.1 - 2.1e-73 241.1 13.8 8e-09 35.8 0.0 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_17 PF13431.1 ERZ99580.1 - 0.035 14.2 10.1 36 4.9 0.0 7.1 5 4 3 8 8 8 0 Tetratricopeptide repeat Fucokinase PF07959.7 ERZ99583.1 - 3.8e-28 98.1 2.6 9e-28 96.9 1.8 1.7 1 1 0 1 1 1 1 L-fucokinase DUF2824 PF11039.3 ERZ99583.1 - 0.0038 16.9 0.1 0.031 13.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2824) KH_4 PF13083.1 ERZ99583.1 - 0.018 14.7 0.0 0.077 12.6 0.0 2.1 1 0 0 1 1 1 0 KH domain Nrap PF03813.9 ERZ99584.1 - 1.8e-278 926.1 6.2 4.4e-278 924.8 4.3 1.6 1 1 0 1 1 1 1 Nrap protein F5_F8_type_C PF00754.20 ERZ99585.1 - 0.00033 20.5 1.0 0.0025 17.6 0.1 2.5 2 0 0 2 2 2 1 F5/8 type C domain Glyco_transf_64 PF09258.5 ERZ99585.1 - 0.0014 17.8 0.0 0.0027 16.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain HAD PF12710.2 ERZ99586.1 - 1.2e-13 51.6 0.0 4.6e-13 49.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ERZ99586.1 - 4.3e-13 49.0 0.0 1.4e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 ERZ99586.1 - 6.3e-13 49.6 0.0 9.1e-08 32.7 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ERZ99586.1 - 1.9e-11 43.4 1.9 6e-11 41.8 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.7 ERZ99586.1 - 0.0035 16.9 0.2 0.0035 16.9 0.2 2.8 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ERZ99586.1 - 0.022 14.9 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2749 PF10907.3 ERZ99586.1 - 0.06 13.2 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Cation_ATPase_C PF00689.16 ERZ99586.1 - 0.18 11.3 21.5 0.014 14.9 8.4 3.1 3 1 0 3 3 3 0 Cation transporting ATPase, C-terminus Epimerase PF01370.16 ERZ99587.1 - 4.6e-66 222.6 0.0 6.3e-66 222.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ERZ99587.1 - 9.6e-07 27.9 0.0 1.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 ERZ99587.1 - 0.00011 21.5 0.0 0.00033 19.9 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family Epimerase_Csub PF13950.1 ERZ99587.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit Polysacc_synt_2 PF02719.10 ERZ99587.1 - 0.021 13.7 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 ERZ99587.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.6 1 1 0 1 1 1 0 NADH(P)-binding Arf PF00025.16 ERZ99588.1 - 2.9e-77 257.8 0.1 3.3e-77 257.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ERZ99588.1 - 7.5e-14 51.4 0.0 7.9e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ERZ99588.1 - 8.6e-12 44.6 0.0 1e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ERZ99588.1 - 2e-11 43.2 1.2 1.5e-07 30.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 ERZ99588.1 - 2e-10 40.2 0.0 2.3e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ERZ99588.1 - 4.9e-07 30.2 0.0 6.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ERZ99588.1 - 0.0002 21.2 0.0 0.00026 20.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 ERZ99588.1 - 0.0026 16.8 0.1 0.0046 16.0 0.1 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 ERZ99588.1 - 0.029 13.7 0.1 0.16 11.4 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain MFS_1 PF07690.11 ERZ99589.1 - 1.5e-19 69.9 16.2 3.4e-19 68.7 11.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily ATG22 PF11700.3 ERZ99589.1 - 0.017 13.6 14.1 0.016 13.6 4.5 2.1 1 1 1 2 2 2 0 Vacuole effluxer Atg22 like MFS_3 PF05977.8 ERZ99589.1 - 0.025 12.6 4.6 0.035 12.2 3.2 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector PUCC PF03209.10 ERZ99589.1 - 0.29 9.8 8.7 0.9 8.1 6.0 1.8 1 1 0 1 1 1 0 PUCC protein OATP PF03137.15 ERZ99589.1 - 2.9 5.8 11.7 0.26 9.3 1.5 2.8 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family RVT_1 PF00078.22 ERZ99591.1 - 2.6e-10 40.0 0.1 3.2e-10 39.7 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ToxN_toxin PF13958.1 ERZ99592.1 - 0.095 12.3 0.7 0.14 11.8 0.5 1.1 1 0 0 1 1 1 0 Toxin ToxN, type III toxin-antitoxin system MHC_II_alpha PF00993.15 ERZ99593.1 - 0.034 13.7 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain DDE_1 PF03184.14 ERZ99598.1 - 9.6e-17 60.8 1.3 6.9e-14 51.5 0.0 2.9 2 1 2 4 4 4 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ERZ99598.1 - 1.5e-07 31.0 0.5 3.4e-07 29.9 0.1 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DUF1939 PF09154.5 ERZ99598.1 - 0.012 15.5 2.1 0.019 14.8 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1939) Mre11_DNA_bind PF04152.9 ERZ99598.1 - 0.43 10.4 0.1 0.43 10.4 0.1 2.1 2 0 0 2 2 2 0 Mre11 DNA-binding presumed domain PLDc_N PF13396.1 ERZ99599.1 - 8.5e-13 47.7 4.9 8.5e-13 47.7 3.4 1.5 1 1 1 2 2 2 1 Phospholipase_D-nuclease N-terminal PsbX PF06596.6 ERZ99599.1 - 0.0071 15.9 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 1 Photosystem II reaction centre X protein (PsbX) DUF1980 PF09323.5 ERZ99599.1 - 0.015 15.0 1.2 0.017 14.9 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Glucos_trans_II PF14264.1 ERZ99599.1 - 0.022 13.7 4.0 0.024 13.6 2.8 1.0 1 0 0 1 1 1 0 Glucosyl transferase GtrII NfeD PF01957.13 ERZ99599.1 - 0.022 14.8 0.1 0.023 14.8 0.1 1.0 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF2207 PF09972.4 ERZ99599.1 - 0.032 12.8 2.0 0.031 12.8 1.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3784 PF12650.2 ERZ99599.1 - 0.086 12.7 2.2 0.093 12.6 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) SdpI PF13630.1 ERZ99599.1 - 0.13 11.9 5.4 0.16 11.7 3.7 1.1 1 0 0 1 1 1 0 SdpI/YhfL protein family EamA PF00892.15 ERZ99599.1 - 0.18 11.8 3.8 0.2 11.6 2.6 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF3561 PF12084.3 ERZ99599.1 - 0.41 10.5 3.5 0.44 10.4 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3561) ABC2_membrane_3 PF12698.2 ERZ99599.1 - 0.65 8.9 4.3 0.72 8.8 3.0 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-LITAF-like PF10601.4 ERZ99599.1 - 3.4 7.6 4.7 1.1 9.2 1.4 1.6 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain DUF2408 PF10303.4 ERZ99600.1 - 0.52 10.4 3.4 1.6 8.8 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) HMG_box PF00505.14 ERZ99601.1 - 2.8e-05 24.2 7.9 0.00033 20.8 0.3 2.8 3 0 0 3 3 3 2 HMG (high mobility group) box Rubella_E2 PF05749.6 ERZ99601.1 - 0.15 11.2 0.1 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Apis_Csd PF11671.3 ERZ99602.1 - 0.019 14.7 2.6 0.021 14.6 1.8 1.0 1 0 0 1 1 1 0 Complementary sex determiner protein SR-25 PF10500.4 ERZ99602.1 - 1.3 8.4 10.0 1.5 8.2 6.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sel1 PF08238.7 ERZ99604.1 - 2.6e-73 240.8 6.9 1.9e-08 34.6 0.0 9.1 9 0 0 9 9 9 8 Sel1 repeat TPR_16 PF13432.1 ERZ99604.1 - 9.6e-09 35.6 0.2 5.1 7.9 0.0 5.4 2 1 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ99604.1 - 8.6e-05 22.8 18.6 0.97 9.8 0.5 6.7 2 1 3 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ99604.1 - 0.00046 20.5 5.4 19 6.2 0.2 6.3 5 2 3 8 8 8 0 Tetratricopeptide repeat NIL PF09383.5 ERZ99604.1 - 0.0014 18.1 0.1 7.3 6.2 0.0 4.3 4 1 0 4 4 4 1 NIL domain DUF494 PF04361.8 ERZ99604.1 - 0.01 15.5 7.6 11 5.7 0.0 4.7 1 1 1 3 3 3 0 Protein of unknown function (DUF494) PPR PF01535.15 ERZ99604.1 - 0.03 14.2 9.8 33 4.7 0.0 6.3 7 0 0 7 7 7 0 PPR repeat Peptidase_C14 PF00656.17 ERZ99604.1 - 0.03 13.9 0.1 2.5 7.7 0.0 2.5 1 1 0 2 2 2 0 Caspase domain TPR_20 PF14561.1 ERZ99604.1 - 0.063 13.4 7.5 20 5.4 1.9 4.0 1 1 3 4 4 4 0 Tetratricopeptide repeat SnoaL_2 PF12680.2 ERZ99604.1 - 0.12 12.7 0.1 68 3.9 0.0 3.6 2 2 2 4 4 4 0 SnoaL-like domain Prenyltrans_1 PF13243.1 ERZ99604.1 - 0.48 10.4 3.3 20 5.2 0.1 3.5 1 1 3 4 4 4 0 Prenyltransferase-like TPR_2 PF07719.12 ERZ99604.1 - 0.49 10.4 26.7 26 5.0 0.3 8.6 8 1 0 8 8 8 0 Tetratricopeptide repeat Na_Ca_ex PF01699.19 ERZ99605.1 - 2.9e-19 69.0 27.0 1.2e-13 50.8 5.6 2.7 2 1 0 2 2 2 2 Sodium/calcium exchanger protein NTPase_P4 PF11602.3 ERZ99605.1 - 0.19 10.6 1.1 0.29 10.0 0.8 1.3 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 UPF0180 PF03698.8 ERZ99606.1 - 0.043 13.6 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) KH_1 PF00013.24 ERZ99607.1 - 4e-12 45.6 1.4 4e-12 45.6 1.0 2.9 4 0 0 4 4 4 1 KH domain KH_3 PF13014.1 ERZ99607.1 - 1.5e-06 27.6 3.3 2.1e-06 27.2 0.6 2.5 2 0 0 2 2 2 1 KH domain KH_2 PF07650.12 ERZ99607.1 - 0.0077 15.7 6.2 0.0095 15.4 0.3 3.2 3 0 0 3 3 3 1 KH domain polyprenyl_synt PF00348.12 ERZ99608.1 - 6.8e-78 261.0 0.0 7.8e-78 260.9 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase GARS_A PF01071.14 ERZ99609.1 - 0.063 12.8 0.1 0.075 12.5 0.1 1.1 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Exo_endo_phos_2 PF14529.1 ERZ99610.1 - 7.3e-09 35.2 1.8 7.8e-09 35.1 0.5 1.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ99610.1 - 2.2e-06 27.8 0.0 2.7e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NOC3p PF07540.6 ERZ99611.1 - 0.24 11.7 2.1 0.39 11.0 0.5 1.9 1 1 1 2 2 2 0 Nucleolar complex-associated protein Rota_NSP4 PF01452.11 ERZ99611.1 - 0.36 10.1 3.6 0.59 9.4 2.5 1.3 1 0 0 1 1 1 0 Rotavirus non structural protein Sel1 PF08238.7 ERZ99614.1 - 5.3e-117 379.7 75.0 6.7e-12 45.6 0.5 13.1 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ERZ99614.1 - 0.0004 20.6 35.5 16 6.2 0.0 11.1 12 0 0 12 12 12 3 Tetratricopeptide repeat DUF4037 PF13228.1 ERZ99614.1 - 0.025 14.8 0.1 19 5.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4037) DUF2853 PF11015.3 ERZ99614.1 - 1.5 9.2 9.5 20 5.7 0.1 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF2853) AIG1 PF04548.11 ERZ99615.1 - 8.4e-25 87.1 0.5 8.4e-25 87.1 0.3 1.7 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ERZ99615.1 - 2.2e-06 27.5 0.1 6.7e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gly-zipper_Omp PF13488.1 ERZ99615.1 - 0.0067 16.0 6.9 0.011 15.3 4.8 1.3 1 0 0 1 1 1 1 Glycine zipper Dynamin_N PF00350.18 ERZ99615.1 - 0.0075 16.1 0.0 0.0075 16.1 0.0 3.2 2 1 0 2 2 1 1 Dynamin family Presenilin PF01080.12 ERZ99615.1 - 0.01 14.7 2.6 0.014 14.2 1.8 1.1 1 0 0 1 1 1 0 Presenilin Gly-zipper_OmpA PF13436.1 ERZ99615.1 - 0.01 15.4 0.0 0.028 14.0 0.0 1.8 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Romo1 PF10247.4 ERZ99615.1 - 0.035 14.3 5.3 0.067 13.3 3.7 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_YMGG PF13441.1 ERZ99615.1 - 0.06 12.8 7.3 0.099 12.1 5.1 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper Bacteriocin_IIc PF10439.4 ERZ99615.1 - 0.28 11.3 6.1 0.54 10.4 4.3 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide TraT PF05818.7 ERZ99615.1 - 0.45 9.8 4.7 2.1 7.7 0.0 2.5 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein MIP-T3 PF10243.4 ERZ99615.1 - 2.2 6.6 46.1 3.6 5.9 31.9 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NmrA PF05368.8 ERZ99616.1 - 2.1e-32 112.2 0.0 2.8e-32 111.8 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ERZ99616.1 - 5.5e-08 33.0 0.0 6.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ERZ99616.1 - 1e-05 24.3 0.0 1.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ERZ99616.1 - 0.011 15.3 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 ERZ99616.1 - 0.082 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.13 ERZ99616.1 - 0.088 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain F-box-like PF12937.2 ERZ99618.1 - 0.00049 19.7 1.3 0.0023 17.5 1.0 2.1 2 0 0 2 2 2 1 F-box-like DUF2232 PF09991.4 ERZ99618.1 - 0.024 13.6 0.1 0.053 12.5 0.1 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Dicty_CAR PF05462.6 ERZ99619.1 - 2.3e-05 23.4 3.7 2.3e-05 23.4 2.5 1.5 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.19 ERZ99619.1 - 0.0083 15.2 7.8 0.039 13.0 3.5 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) DUF966 PF06136.8 ERZ99619.1 - 0.026 13.9 0.3 0.034 13.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Presenilin PF01080.12 ERZ99619.1 - 2.4 6.8 12.0 4.9 5.8 5.0 2.2 2 0 0 2 2 2 0 Presenilin DUF1980 PF09323.5 ERZ99619.1 - 4.7 6.9 7.2 14 5.3 5.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PCEMA1 PF07418.6 ERZ99620.1 - 0.0048 16.2 9.7 0.0055 16.1 6.7 1.1 1 0 0 1 1 1 1 Acidic phosphoprotein precursor PCEMA1 CENP-N PF05238.8 ERZ99620.1 - 0.049 12.6 6.2 0.059 12.4 4.3 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Merozoite_SPAM PF07133.6 ERZ99620.1 - 0.23 11.3 17.1 0.28 11.0 11.9 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Peptidase_M4 PF01447.13 ERZ99620.1 - 0.38 10.8 2.9 0.22 11.6 0.4 1.8 1 1 1 2 2 2 0 Thermolysin metallopeptidase, catalytic domain Tox-SHH PF15652.1 ERZ99622.1 - 0.058 13.9 0.6 0.26 11.9 0.1 2.1 2 0 0 2 2 2 0 HNH/Endo VII superfamily toxin with a SHH signature ParB PF08775.5 ERZ99622.1 - 0.22 11.8 4.5 0.37 11.1 3.1 1.3 1 0 0 1 1 1 0 ParB family PPV_E1_N PF00524.13 ERZ99622.1 - 0.82 9.8 3.6 1.4 9.1 2.5 1.3 1 0 0 1 1 1 0 E1 Protein, N terminal domain DUF3760 PF12586.3 ERZ99625.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) SPATA24 PF15175.1 ERZ99626.1 - 0.036 13.7 0.3 0.061 13.0 0.2 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 p450 PF00067.17 ERZ99627.1 - 9.7e-23 80.4 0.0 1.1e-22 80.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DDE_1 PF03184.14 ERZ99630.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease RNase_H PF00075.19 ERZ99631.1 - 3.4e-15 56.5 0.0 5.9e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF3646 PF12362.3 ERZ99631.1 - 0.023 14.6 0.2 0.081 12.8 0.0 1.9 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal F-box-like PF12937.2 ERZ99633.1 - 0.076 12.7 0.8 1.6 8.5 0.1 2.9 3 0 0 3 3 3 0 F-box-like Sel1 PF08238.7 ERZ99634.1 - 8.4e-123 398.1 64.0 8.8e-13 48.4 0.5 11.3 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ERZ99634.1 - 9.9e-09 35.0 29.9 2 9.0 0.1 9.3 9 1 0 9 9 9 4 Tetratricopeptide repeat MIT PF04212.13 ERZ99634.1 - 3.8e-05 23.4 48.9 3.5 7.5 0.3 11.1 10 1 1 11 11 11 5 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ99634.1 - 0.00013 21.8 27.0 21 5.6 0.1 11.0 11 0 0 11 11 11 0 Tetratricopeptide repeat Pkinase PF00069.20 ERZ99634.1 - 0.00014 21.1 0.0 0.00025 20.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Peptidase_C14 PF00656.17 ERZ99634.1 - 0.0003 20.5 0.0 3.3 7.3 0.0 5.1 1 1 2 3 3 3 1 Caspase domain Flu_M1_C PF08289.6 ERZ99634.1 - 0.0025 17.7 0.0 20 5.2 0.0 5.2 4 2 3 7 7 7 0 Influenza Matrix protein (M1) C-terminal domain Surfac_D-trimer PF09006.6 ERZ99634.1 - 0.006 16.2 18.5 71 3.2 0.0 9.0 10 0 0 10 10 10 0 Lung surfactant protein D coiled-coil trimerisation Pkinase_Tyr PF07714.12 ERZ99634.1 - 0.0082 15.2 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_11 PF13414.1 ERZ99634.1 - 0.037 13.6 57.5 1.1 8.9 5.4 8.7 1 1 8 9 9 9 0 TPR repeat TPR_12 PF13424.1 ERZ99634.1 - 0.24 11.3 36.1 0.87 9.5 0.8 8.2 2 2 8 10 10 10 0 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ99634.1 - 7.2 6.6 12.0 1.7 8.6 0.3 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat RRM_6 PF14259.1 ERZ99635.1 - 4.2e-06 26.6 0.2 0.0063 16.4 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ERZ99635.1 - 0.0016 17.9 0.0 1.8 8.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ERZ99635.1 - 0.011 15.5 0.1 0.042 13.6 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif TSC21 PF15217.1 ERZ99635.1 - 0.092 12.4 1.3 14 5.2 0.1 2.9 2 1 1 3 3 3 0 TSC21 family Nup35_RRM_2 PF14605.1 ERZ99636.1 - 0.047 13.4 0.1 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-C4pol PF14260.1 ERZ99637.1 - 0.061 13.3 0.5 0.12 12.3 0.3 1.5 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta TRP_N PF14558.1 ERZ99637.1 - 3.1 7.8 6.2 11 6.0 0.5 2.2 1 1 1 2 2 2 0 ML-like domain Root_cap PF06830.6 ERZ99638.1 - 0.042 13.6 0.1 5.1 7.0 0.0 2.6 2 1 1 3 3 3 0 Root cap FAD_binding_3 PF01494.14 ERZ99639.1 - 7.5e-13 48.2 0.0 3.8e-08 32.7 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain Pyr_redox_3 PF13738.1 ERZ99639.1 - 7.1e-06 26.2 0.0 5.9e-05 23.2 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ERZ99639.1 - 2.2e-05 24.2 0.0 9.5e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ERZ99639.1 - 0.0041 17.1 0.0 0.0081 16.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 ERZ99639.1 - 0.017 14.0 0.0 0.29 10.0 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.9 ERZ99639.1 - 0.019 14.8 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ERZ99639.1 - 0.13 11.3 0.0 0.25 10.3 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Erf4 PF10256.4 ERZ99641.1 - 0.091 12.6 0.2 0.12 12.2 0.1 1.3 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family zinc_ribbon_2 PF13240.1 ERZ99642.1 - 0.045 13.2 0.2 0.09 12.2 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Kelch_4 PF13418.1 ERZ99644.1 - 3.6e-21 74.6 5.6 0.00029 20.5 0.0 6.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ERZ99644.1 - 1.7e-19 69.0 13.4 6e-05 22.4 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 ERZ99644.1 - 1.3e-18 66.3 13.7 0.00068 19.7 0.1 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ERZ99644.1 - 1.1e-17 63.6 10.6 0.00021 21.1 0.3 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ERZ99644.1 - 6.5e-17 60.5 5.5 7.8e-05 22.2 0.0 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ERZ99644.1 - 1.5e-14 53.6 5.9 0.061 13.5 0.0 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain FBA_3 PF08268.7 ERZ99644.1 - 0.016 14.9 0.1 4.6 6.9 0.0 2.4 2 0 0 2 2 2 0 F-box associated domain DUF4448 PF14610.1 ERZ99644.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) BTB_2 PF02214.17 ERZ99649.1 - 5.1e-08 33.0 0.3 6.8e-08 32.6 0.2 1.2 1 0 0 1 1 1 1 BTB/POZ domain CHASE4 PF05228.8 ERZ99649.1 - 0.23 11.0 0.8 0.47 10.0 0.4 1.5 1 1 1 2 2 2 0 CHASE4 domain Ricin_B_lectin PF00652.17 ERZ99650.1 - 0.011 15.7 0.3 0.022 14.7 0.2 1.5 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain DUF2726 PF10881.3 ERZ99650.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) DUF4379 PF14311.1 ERZ99651.1 - 2.2e-10 40.2 31.7 0.013 15.3 2.4 4.4 3 1 1 4 4 4 4 Domain of unknown function (DUF4379) zf-Di19 PF05605.7 ERZ99651.1 - 0.00059 19.8 2.9 11 6.2 0.1 3.5 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding Redoxin PF08534.5 ERZ99651.1 - 0.1 12.1 4.4 1.3 8.5 0.0 3.1 3 0 0 3 3 3 0 Redoxin Thioredoxin_2 PF13098.1 ERZ99651.1 - 0.26 11.4 5.3 5.2 7.3 0.0 3.0 2 1 1 3 3 3 0 Thioredoxin-like domain zf-C2H2_2 PF12756.2 ERZ99651.1 - 3.4 7.8 6.7 2.1 8.4 0.6 2.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Cytochrom_c3_2 PF14537.1 ERZ99651.1 - 5.9 7.3 9.8 0.41 11.0 2.5 2.3 1 1 1 2 2 2 0 Cytochrome c3 DUF953 PF06110.6 ERZ99651.1 - 8.4 5.8 10.4 2 7.8 0.1 3.1 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF953) WLM PF08325.5 ERZ99654.1 - 0.018 14.8 0.7 0.023 14.5 0.5 1.3 1 0 0 1 1 1 0 WLM domain TFIIB PF00382.14 ERZ99656.1 - 1.3e-08 34.5 0.0 2.4e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Cyclin_N PF00134.18 ERZ99656.1 - 0.1 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Ndc1_Nup PF09531.5 ERZ99656.1 - 5.6 5.2 6.8 7.7 4.8 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup His_Phos_2 PF00328.17 ERZ99659.1 - 5.6e-19 68.6 0.0 7.1e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Phage_int_SAM_4 PF13495.1 ERZ99660.1 - 0.051 13.8 0.4 5 7.5 0.0 2.1 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain Sel1 PF08238.7 ERZ99661.1 - 1.4e-09 38.2 0.0 2.5e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Sel1 repeat Form_Nir_trans PF01226.12 ERZ99662.1 - 0.011 14.6 0.1 0.012 14.4 0.1 1.0 1 0 0 1 1 1 0 Formate/nitrite transporter UvrD_C_2 PF13538.1 ERZ99662.1 - 0.049 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Jacalin PF01419.12 ERZ99663.1 - 1.6e-07 31.2 0.8 5.1e-07 29.6 0.6 1.8 1 1 0 1 1 1 1 Jacalin-like lectin domain tRNA_SAD PF07973.9 ERZ99664.1 - 5.6e-09 35.7 0.5 2.9e-07 30.2 0.1 2.4 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 ERZ99664.1 - 2.1e-06 26.3 0.0 3.1e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) Sel1 PF08238.7 ERZ99669.1 - 6.1e-38 128.4 9.5 3.7e-09 36.9 0.0 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ERZ99669.1 - 0.0019 18.5 1.2 2.4 8.7 0.0 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ERZ99669.1 - 0.14 12.2 0.0 54 3.9 0.0 3.0 1 1 2 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain TPR_12 PF13424.1 ERZ99669.1 - 0.18 11.7 1.2 16 5.4 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ERZ99669.1 - 0.34 10.8 10.9 26 4.8 0.8 4.0 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ERZ99669.1 - 0.67 9.8 2.4 26 4.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ99669.1 - 2.8 7.6 0.0 2.8 7.6 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ99669.1 - 6.1 7.0 0.0 6.1 7.0 0.0 5.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ99669.1 - 6.9 6.3 7.4 9.1 6.0 0.7 3.2 2 2 1 3 3 3 0 TPR repeat Pox_D5 PF03288.11 ERZ99670.1 - 2.4e-06 27.7 0.0 8.6e-06 25.9 0.0 2.0 1 0 0 1 1 1 1 Poxvirus D5 protein-like Ank_2 PF12796.2 ERZ99672.1 - 1.6e-11 44.3 0.2 6.7e-06 26.3 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ERZ99672.1 - 2e-10 40.8 1.8 2e-05 24.9 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ERZ99672.1 - 6.7e-10 38.2 0.5 6.5e-06 25.6 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 ERZ99672.1 - 4.9e-09 35.5 0.4 0.00089 19.2 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ERZ99672.1 - 9.7e-09 35.1 0.5 0.00075 19.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.8 ERZ99672.1 - 0.0019 17.8 5.1 0.0025 17.4 0.0 3.3 2 2 0 2 2 2 1 KilA-N domain AAA_14 PF13173.1 ERZ99673.1 - 0.015 15.2 0.4 0.02 14.8 0.2 1.3 1 1 0 1 1 1 0 AAA domain HTH_Tnp_Tc5 PF03221.11 ERZ99677.1 - 9.3e-07 28.5 0.1 9e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ERZ99677.1 - 0.00011 21.5 0.3 0.00017 20.9 0.2 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain PAX PF00292.13 ERZ99677.1 - 0.047 13.3 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain XkdN PF08890.6 ERZ99677.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Phage XkdN-like protein Lactamase_B PF00753.22 ERZ99678.1 - 2.2e-17 63.3 0.4 2.6e-17 63.1 0.3 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ERZ99678.1 - 1.9e-06 27.6 0.2 2.3e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Sel1 PF08238.7 ERZ99679.1 - 6.5e-177 570.1 75.6 6.1e-14 52.1 0.7 15.3 15 0 0 15 15 15 15 Sel1 repeat TPR_6 PF13174.1 ERZ99679.1 - 4.1e-25 86.4 44.8 0.46 11.0 0.0 14.9 15 0 0 15 15 15 13 Tetratricopeptide repeat AviRa PF11599.3 ERZ99679.1 - 1.5e-05 24.1 1.8 12 4.7 0.0 6.9 3 3 4 8 8 8 1 RRNA methyltransferase AviRa Pkinase PF00069.20 ERZ99679.1 - 0.0056 15.8 0.0 0.0086 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99679.1 - 0.032 13.2 0.0 0.046 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ERZ99680.1 - 2.1e-42 144.9 0.0 2.4e-42 144.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99680.1 - 2e-38 132.0 0.0 2.4e-38 131.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ99680.1 - 0.00084 18.4 0.2 0.0012 17.9 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99680.1 - 0.028 14.1 0.1 0.036 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ99680.1 - 0.039 13.3 0.3 0.064 12.5 0.2 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ99680.1 - 0.051 12.9 0.1 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Cys_Met_Meta_PP PF01053.15 ERZ99681.1 - 2.7e-138 460.4 0.0 3e-138 460.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ERZ99681.1 - 1.4e-08 34.1 0.0 2.2e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 ERZ99681.1 - 5.5e-08 31.9 0.6 1.1e-07 30.9 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 ERZ99681.1 - 1.3e-05 24.3 0.1 2.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.6 ERZ99681.1 - 0.00048 18.5 0.1 0.00068 18.0 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.16 ERZ99681.1 - 0.00077 18.6 0.0 0.0018 17.4 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.11 ERZ99681.1 - 0.0034 16.1 0.0 0.0052 15.5 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Sel1 PF08238.7 ERZ99682.1 - 3.8e-86 281.6 25.0 1.6e-12 47.6 0.7 9.1 9 0 0 9 9 9 9 Sel1 repeat MIT PF04212.13 ERZ99682.1 - 0.00052 19.8 19.1 0.28 11.0 0.3 6.4 4 2 4 8 8 8 5 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ERZ99682.1 - 0.0024 18.2 12.1 4 8.1 0.3 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat V-set PF07686.12 ERZ99682.1 - 0.055 13.3 0.2 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin V-set domain zf-C2H2 PF00096.21 ERZ99683.1 - 0.0013 18.8 2.7 0.0026 17.9 1.9 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ99683.1 - 0.015 15.6 3.3 0.034 14.4 2.3 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.2 ERZ99683.1 - 0.032 14.4 3.5 0.056 13.6 2.4 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DUF629 PF04780.7 ERZ99683.1 - 0.093 11.2 1.0 0.13 10.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Nucleoside_tran PF01733.13 ERZ99683.1 - 0.15 11.1 0.1 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter zf-C2H2_6 PF13912.1 ERZ99683.1 - 0.24 11.3 3.5 0.51 10.3 2.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Eaf7 PF07904.8 ERZ99683.1 - 0.5 10.3 4.2 0.17 11.8 0.5 1.8 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Sialidase_penC PF12135.3 ERZ99683.1 - 0.7 9.5 4.0 19 5.0 1.2 2.8 2 0 0 2 2 2 0 Sialidase enzyme penultimate C terminal domain zf-C2H2 PF00096.21 ERZ99684.1 - 0.001 19.3 3.1 0.0039 17.4 2.1 2.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ99684.1 - 0.02 15.1 3.6 0.084 13.2 2.5 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.2 ERZ99684.1 - 0.11 12.7 3.0 0.29 11.3 2.1 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ERZ99684.1 - 0.56 10.1 3.2 1.3 9.0 2.2 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger Pkinase_Tyr PF07714.12 ERZ99685.1 - 5.3e-38 130.5 0.0 2.2e-12 46.5 0.0 7.0 5 1 2 7 7 7 6 Protein tyrosine kinase Pkinase PF00069.20 ERZ99685.1 - 2e-29 102.5 17.9 8.3e-14 51.3 0.0 6.9 6 2 1 7 7 7 4 Protein kinase domain BCS1_N PF08740.6 ERZ99685.1 - 2e-06 27.5 0.5 0.06 12.9 0.0 5.0 4 1 1 5 5 5 2 BCS1 N terminal CLTH PF10607.4 ERZ99685.1 - 0.00099 18.8 5.4 2.6 7.7 0.1 5.0 3 2 1 4 4 4 3 CTLH/CRA C-terminal to LisH motif domain PX PF00787.19 ERZ99686.1 - 2.4e-18 65.9 0.4 6.4e-18 64.6 0.3 1.7 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.4 ERZ99686.1 - 0.029 13.6 5.1 0.96 8.6 3.5 2.1 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein Tmemb_cc2 PF10267.4 ERZ99686.1 - 0.056 12.0 5.8 0.016 13.8 1.3 2.0 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein TrmB PF01978.14 ERZ99690.1 - 6.4e-06 25.7 0.0 1.9e-05 24.3 0.0 1.7 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.1 ERZ99690.1 - 0.00033 20.7 0.0 0.00036 20.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_IclR PF09339.5 ERZ99690.1 - 0.00091 18.7 0.0 0.0022 17.5 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_23 PF13384.1 ERZ99690.1 - 0.00095 18.7 0.0 0.0035 16.9 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.2 ERZ99690.1 - 0.0033 17.0 0.0 0.03 13.9 0.0 2.1 2 0 0 2 2 2 1 MarR family HTH_43 PF09904.4 ERZ99690.1 - 0.0045 16.7 0.0 0.02 14.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.1 ERZ99690.1 - 0.0049 17.6 0.0 0.0079 16.9 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 ERZ99690.1 - 0.0056 16.0 0.1 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 ERZ99690.1 - 0.017 15.1 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Phage_AlpA PF05930.7 ERZ99690.1 - 0.029 14.0 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) zf-ISL3 PF14690.1 ERZ99690.1 - 0.047 13.7 0.1 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 PAX PF00292.13 ERZ99690.1 - 0.073 12.7 0.0 0.086 12.5 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain CENP-B_N PF04218.8 ERZ99690.1 - 0.084 12.3 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain zf-C2H2 PF00096.21 ERZ99691.1 - 0.0038 17.4 0.1 0.0052 17.0 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ERZ99691.1 - 0.017 15.4 0.2 0.026 14.8 0.1 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ERZ99691.1 - 0.024 14.7 0.0 0.048 13.8 0.0 1.5 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ERZ99692.1 - 0.068 13.5 5.2 5.8 7.4 2.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ERZ99692.1 - 0.13 12.6 4.5 3.8 8.0 2.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type MFS_2 PF13347.1 ERZ99693.1 - 0.055 11.8 0.2 0.058 11.7 0.2 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein Gmad2 PF10648.4 ERZ99696.1 - 0.045 13.9 0.0 0.05 13.7 0.0 1.0 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination Kelch_5 PF13854.1 ERZ99697.1 - 1.8e-19 69.2 7.9 3.2e-05 23.7 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ERZ99697.1 - 2e-19 69.0 13.1 1.7e-06 27.6 0.0 6.2 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ERZ99697.1 - 2.1e-15 56.3 8.9 3.9e-05 23.6 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ERZ99697.1 - 3e-12 46.1 13.7 0.065 13.4 0.1 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ERZ99697.1 - 4e-10 39.0 8.0 0.15 11.5 0.1 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ERZ99697.1 - 2.3e-09 36.6 2.5 0.16 11.7 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.6 ERZ99697.1 - 0.013 14.5 0.0 0.023 13.7 0.0 1.5 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus Thr_synth_N PF14821.1 ERZ99698.1 - 9.2e-29 99.3 0.0 1.5e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Threonine synthase N terminus PBP_like PF12727.2 ERZ99698.1 - 0.11 11.4 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 PBP superfamily domain Med15_fungi PF05397.7 ERZ99699.1 - 5.4e-13 48.9 2.1 1.5e-12 47.5 1.5 1.7 1 0 0 1 1 1 1 Mediator complex subunit 15 Smac_DIABLO PF09057.5 ERZ99699.1 - 0.016 14.3 0.0 0.41 9.7 0.0 2.1 2 0 0 2 2 2 0 Second Mitochondria-derived Activator of Caspases NUFIP1 PF10453.4 ERZ99699.1 - 0.077 12.5 0.7 0.18 11.3 0.5 1.6 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) TIP39 PF14980.1 ERZ99700.1 - 0.012 15.2 1.2 0.043 13.4 0.1 2.3 2 0 0 2 2 2 0 TIP39 peptide DUF4448 PF14610.1 ERZ99704.1 - 0.0016 17.9 0.1 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) GPI-anchored PF10342.4 ERZ99704.1 - 0.0036 17.7 0.0 0.0058 17.0 0.0 1.4 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Herpes_UL79 PF03049.9 ERZ99704.1 - 0.038 13.0 0.0 0.058 12.4 0.0 1.2 1 0 0 1 1 1 0 UL79 family ubiquitin PF00240.18 ERZ99705.1 - 1.1e-09 37.5 0.0 1.9e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 ERZ99705.1 - 0.00026 21.1 0.1 0.00081 19.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 ERZ99705.1 - 0.0014 18.2 0.0 0.0017 17.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Tyr-DNA_phospho PF06087.7 ERZ99706.1 - 1.3e-115 386.5 4.5 1.6e-115 386.2 3.1 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Thioredoxin_3 PF13192.1 ERZ99706.1 - 0.049 13.4 0.0 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain CTD_bind PF04818.8 ERZ99707.1 - 1.8e-24 85.7 1.6 3.7e-24 84.7 0.2 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Gp-FAR-1 PF05823.7 ERZ99707.1 - 0.039 13.9 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF1059 PF06348.6 ERZ99708.1 - 0.027 14.2 0.4 0.046 13.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1059) RE_NgoFVII PF09565.5 ERZ99708.1 - 0.21 10.4 2.5 0.27 10.1 1.7 1.1 1 0 0 1 1 1 0 NgoFVII restriction endonuclease BTB PF00651.26 ERZ99710.1 - 9.8e-16 57.7 0.2 1.6e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99710.1 - 4.2e-12 46.2 0.2 8.2e-12 45.3 0.1 1.4 1 0 0 1 1 1 1 TLD BTB_2 PF02214.17 ERZ99710.1 - 0.05 13.8 0.1 0.097 12.8 0.1 1.5 1 0 0 1 1 1 0 BTB/POZ domain OTT_1508_deam PF14441.1 ERZ99712.1 - 1.1e-06 28.5 0.4 1.4e-06 28.1 0.3 1.3 1 1 0 1 1 1 1 OTT_1508-like deaminase PglZ PF08665.7 ERZ99712.1 - 0.00049 19.8 0.0 0.00067 19.3 0.0 1.3 1 0 0 1 1 1 1 PglZ domain DYW_deaminase PF14432.1 ERZ99712.1 - 0.1 12.5 0.3 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases Aha1_N PF09229.6 ERZ99715.1 - 0.09 12.5 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal WAC_Acf1_DNA_bd PF10537.4 ERZ99716.1 - 0.016 15.3 0.6 0.03 14.4 0.1 1.8 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal zf-RVT PF13966.1 ERZ99716.1 - 0.02 15.1 1.3 0.077 13.3 0.1 2.2 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase RVT_1 PF00078.22 ERZ99718.1 - 1.5e-12 47.3 0.0 2.1e-09 37.0 0.0 2.8 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.18 ERZ99719.1 - 5.3e-06 26.5 1.3 1e-05 25.6 0.9 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ERZ99719.1 - 2.9e-05 23.6 0.2 6.8e-05 22.4 0.2 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ESAG1 PF03238.8 ERZ99719.1 - 0.18 11.1 0.1 0.29 10.4 0.1 1.3 1 0 0 1 1 1 0 ESAG protein ESCRT-II PF05871.7 ERZ99722.1 - 0.018 14.9 1.1 0.047 13.6 0.6 1.9 1 1 1 2 2 2 0 ESCRT-II complex subunit CENP-U PF13097.1 ERZ99722.1 - 0.067 13.1 0.7 0.24 11.3 0.0 2.2 2 0 0 2 2 2 0 CENP-A nucleosome associated complex (NAC) subunit DUF4638 PF15472.1 ERZ99723.1 - 0.041 13.4 5.4 0.048 13.2 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DDHD PF02862.12 ERZ99723.1 - 0.15 11.8 4.9 0.19 11.5 3.4 1.1 1 0 0 1 1 1 0 DDHD domain MACPF PF01823.14 ERZ99723.1 - 0.27 10.9 2.9 0.32 10.6 2.0 1.1 1 0 0 1 1 1 0 MAC/Perforin domain UPF0560 PF10577.4 ERZ99723.1 - 0.62 8.2 6.5 0.75 7.9 4.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Vfa1 PF08432.5 ERZ99723.1 - 0.63 10.0 8.8 0.76 9.7 6.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S49_N PF08496.5 ERZ99723.1 - 0.91 9.3 6.3 1.1 9.0 4.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Prefoldin PF02996.12 ERZ99724.1 - 0.037 13.6 0.2 0.041 13.5 0.1 1.2 1 0 0 1 1 1 0 Prefoldin subunit Moulting_cycle PF04870.11 ERZ99724.1 - 0.038 13.0 0.5 0.041 12.9 0.3 1.0 1 0 0 1 1 1 0 Moulting cycle HSA PF07529.8 ERZ99724.1 - 0.078 12.7 1.1 0.097 12.4 0.8 1.2 1 0 0 1 1 1 0 HSA DUF3791 PF12668.2 ERZ99726.1 - 0.079 12.5 1.3 0.15 11.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) F-box-like PF12937.2 ERZ99727.1 - 4.6e-05 23.0 6.8 7.7e-05 22.3 3.0 2.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ERZ99727.1 - 0.21 11.3 4.8 0.77 9.4 1.8 3.1 2 1 0 2 2 2 0 F-box domain Pkinase_Tyr PF07714.12 ERZ99728.1 - 3.1e-07 29.7 0.9 4.4e-05 22.6 0.7 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99728.1 - 5.9e-05 22.3 2.5 7.5e-05 22.0 0.7 2.0 2 1 0 2 2 2 1 Protein kinase domain DUF2807 PF10988.3 ERZ99730.1 - 0.21 11.1 3.3 0.75 9.2 2.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2807) Arch_ATPase PF01637.13 ERZ99731.1 - 0.00015 21.5 0.1 0.00052 19.7 0.1 2.1 1 1 0 1 1 1 1 Archaeal ATPase Thioredoxin_6 PF13848.1 ERZ99731.1 - 0.0011 18.7 0.9 1.9 8.2 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like domain Bac_DnaA PF00308.13 ERZ99731.1 - 0.0028 17.3 0.0 0.0088 15.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_10 PF12846.2 ERZ99731.1 - 0.0084 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain DUF3753 PF12575.3 ERZ99731.1 - 0.02 14.6 1.4 2.7 7.8 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) AAA_25 PF13481.1 ERZ99731.1 - 0.021 14.2 0.0 0.19 11.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 ERZ99731.1 - 0.028 13.3 0.0 1.3 7.9 0.0 2.7 1 1 2 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.7 ERZ99731.1 - 0.045 13.4 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF1640 PF07798.6 ERZ99734.1 - 3.3e-37 128.2 3.3 3.6e-37 128.1 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.13 ERZ99734.1 - 0.00018 21.1 2.6 0.00076 19.1 0.6 2.3 2 0 0 2 2 2 1 Homeobox associated leucine zipper FlaC_arch PF05377.6 ERZ99734.1 - 0.0082 16.0 3.8 2 8.3 0.0 2.4 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) DUF4201 PF13870.1 ERZ99734.1 - 0.018 14.4 4.4 0.25 10.7 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Apolipoprotein PF01442.13 ERZ99734.1 - 0.029 13.8 0.5 0.04 13.4 0.4 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain VASP_tetra PF08776.6 ERZ99734.1 - 0.051 12.8 0.5 0.37 10.1 0.3 2.3 2 0 0 2 2 2 0 VASP tetramerisation domain CCDC155 PF14662.1 ERZ99734.1 - 0.076 12.6 6.1 0.6 9.6 1.2 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Kinetocho_Slk19 PF12709.2 ERZ99734.1 - 0.09 12.8 3.5 0.11 12.5 0.6 2.0 2 0 0 2 2 2 0 Central kinetochore-associated HsbA PF12296.3 ERZ99734.1 - 0.1 12.4 0.0 7.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A bZIP_2 PF07716.10 ERZ99734.1 - 0.13 12.1 1.6 0.69 9.7 0.2 2.3 2 1 0 2 2 2 0 Basic region leucine zipper ApoLp-III PF07464.6 ERZ99734.1 - 0.15 12.1 2.1 0.44 10.5 1.5 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.7 ERZ99734.1 - 0.16 11.8 1.1 0.24 11.2 0.8 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ERZ99734.1 - 0.17 11.7 4.2 6.2 6.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Atg14 PF10186.4 ERZ99734.1 - 0.17 10.7 4.0 0.23 10.3 2.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TBPIP PF07106.8 ERZ99734.1 - 0.18 11.3 4.8 0.27 10.7 3.3 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tup_N PF08581.5 ERZ99734.1 - 0.19 11.9 1.9 0.7 10.1 1.3 1.8 1 1 0 1 1 1 0 Tup N-terminal bZIP_1 PF00170.16 ERZ99734.1 - 0.31 11.0 3.6 1.6 8.7 1.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor Kinesin-related PF06548.6 ERZ99734.1 - 0.39 9.2 5.3 0.16 10.4 1.0 1.8 1 1 1 2 2 2 0 Kinesin-related DUF972 PF06156.8 ERZ99734.1 - 0.41 11.0 4.3 3.1 8.1 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF4618 PF15397.1 ERZ99734.1 - 0.49 9.6 4.3 2.2 7.5 3.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Shugoshin_N PF07558.6 ERZ99734.1 - 0.49 10.1 4.3 14 5.5 2.1 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Pox_A_type_inc PF04508.7 ERZ99734.1 - 2.8 7.9 5.8 1.4 8.9 0.5 2.7 2 1 1 3 3 3 0 Viral A-type inclusion protein repeat F-box-like PF12937.2 ERZ99735.1 - 5.2e-05 22.8 0.2 0.0003 20.4 0.0 2.4 2 0 0 2 2 2 1 F-box-like Sfi1 PF08457.5 ERZ99736.1 - 1.1e-12 47.1 41.3 1.1e-11 43.8 28.6 2.1 1 1 0 1 1 1 1 Sfi1 spindle body protein CTP_transf_3 PF02348.14 ERZ99736.1 - 5.4 6.5 13.2 0.029 13.9 1.8 2.5 3 1 0 3 3 3 0 Cytidylyltransferase UQ_con PF00179.21 ERZ99738.1 - 1.4e-44 150.8 0.0 1.6e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UQ_con PF00179.21 ERZ99740.1 - 3.7e-25 87.9 0.0 4e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ERZ99740.1 - 0.0091 15.8 0.2 0.0097 15.7 0.1 1.3 1 1 0 1 1 1 1 RWD domain Dpoe2NT PF12213.3 ERZ99742.1 - 0.045 13.6 0.1 0.09 12.7 0.1 1.5 1 0 0 1 1 1 0 DNA polymerases epsilon N terminal Pyr_redox_2 PF07992.9 ERZ99743.1 - 2.5e-43 148.3 0.3 4.2e-43 147.5 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 ERZ99743.1 - 4.5e-28 97.4 0.8 7.7e-28 96.7 0.5 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 ERZ99743.1 - 1.4e-19 70.2 5.4 2.4e-17 63.0 0.0 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ERZ99743.1 - 2.7e-12 47.2 0.0 1.4e-09 38.2 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 ERZ99743.1 - 6.4e-08 32.0 0.6 4.2e-06 26.1 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 ERZ99743.1 - 2.9e-06 26.4 0.0 7.1e-05 21.8 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.19 ERZ99743.1 - 5.9e-06 25.3 2.7 0.01 14.7 1.9 2.4 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.9 ERZ99743.1 - 7.6e-05 21.3 1.8 0.0073 14.8 0.2 3.1 3 1 1 4 4 4 1 HI0933-like protein NAD_binding_8 PF13450.1 ERZ99743.1 - 0.00029 20.7 1.7 0.00072 19.5 1.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.14 ERZ99743.1 - 0.0014 17.8 1.5 0.054 12.6 0.0 3.1 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 ERZ99743.1 - 0.0014 18.2 0.1 0.025 14.1 0.0 2.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 ERZ99743.1 - 0.0014 17.7 1.2 0.0022 17.1 0.2 1.7 2 0 0 2 2 2 1 Thi4 family UDPG_MGDP_dh_N PF03721.9 ERZ99743.1 - 0.0029 16.9 0.0 0.0054 16.1 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.19 ERZ99743.1 - 0.0036 16.2 0.5 0.0036 16.2 0.4 3.0 4 0 0 4 4 4 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 ERZ99743.1 - 0.01 15.5 1.3 0.039 13.6 0.0 2.4 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 ERZ99743.1 - 0.015 14.3 2.2 2.2 7.2 0.0 2.4 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.1 ERZ99743.1 - 0.015 15.5 0.0 2.2 8.6 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.17 ERZ99743.1 - 0.042 12.7 8.8 0.17 10.6 3.0 2.9 1 1 0 2 2 2 0 Glucose inhibited division protein A RAP PF08373.5 ERZ99743.1 - 0.045 13.5 0.7 0.1 12.3 0.1 1.9 2 0 0 2 2 2 0 RAP domain Glyco_hydro_67N PF03648.9 ERZ99743.1 - 0.093 12.7 0.1 7.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus DUF413 PF04219.7 ERZ99744.1 - 0.067 12.9 0.0 7.4 6.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF BRCT_assoc PF12820.2 ERZ99747.1 - 0.0033 17.1 2.8 0.0042 16.8 2.0 1.1 1 0 0 1 1 1 1 Serine-rich domain associated with BRCT E1_DerP2_DerF2 PF02221.10 ERZ99748.1 - 0.1 12.8 3.7 0.16 12.2 0.6 2.1 2 0 0 2 2 2 0 ML domain FAM176 PF14851.1 ERZ99748.1 - 0.64 9.6 3.5 0.3 10.7 1.0 1.6 2 1 0 2 2 2 0 FAM176 family Hepatitis_core PF00906.15 ERZ99750.1 - 0.061 12.9 0.1 0.066 12.8 0.1 1.0 1 0 0 1 1 1 0 Hepatitis core antigen Palm_thioest PF02089.10 ERZ99750.1 - 0.12 11.2 0.0 0.13 11.2 0.0 1.0 1 0 0 1 1 1 0 Palmitoyl protein thioesterase HMG_box PF00505.14 ERZ99751.1 - 7.9e-12 45.2 4.2 8.7e-12 45.1 2.9 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99751.1 - 0.024 14.9 2.5 0.028 14.7 1.7 1.1 1 0 0 1 1 1 0 HMG-box domain PRTase_2 PF15609.1 ERZ99751.1 - 0.029 13.6 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Phosphoribosyl transferase DUF2600 PF10776.4 ERZ99754.1 - 0.0077 15.1 0.0 0.0094 14.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2600) Carb_anhydrase PF00194.16 ERZ99756.1 - 5.1e-18 64.9 1.8 2.7e-17 62.5 1.3 2.0 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase adh_short PF00106.20 ERZ99758.1 - 0.12 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase O-FucT PF10250.4 ERZ99762.1 - 0.00016 20.9 0.1 0.00038 19.6 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peptidase_M19 PF01244.16 ERZ99762.1 - 0.014 14.3 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) Arrestin_N PF00339.24 ERZ99763.1 - 3.5e-18 65.8 0.0 7.6e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ERZ99763.1 - 1.2e-06 28.7 1.2 3.6e-05 23.8 0.0 2.8 2 2 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 ERZ99763.1 - 0.00032 20.2 0.4 0.0029 17.1 0.0 2.4 2 1 1 3 3 3 1 Arrestin_N terminal like Rgp1 PF08737.5 ERZ99763.1 - 0.005 15.9 1.1 0.11 11.6 0.1 2.2 2 0 0 2 2 2 1 Rgp1 Prenyltransf PF01255.14 ERZ99764.1 - 1.6e-12 47.0 0.4 5.7e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase DUF968 PF06147.6 ERZ99764.1 - 0.035 14.0 0.1 0.067 13.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF968) Pkinase_Tyr PF07714.12 ERZ99765.1 - 0.0012 17.9 0.0 0.0014 17.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3652 PF12372.3 ERZ99766.1 - 0.1 12.2 0.0 0.36 10.4 0.0 1.9 1 0 0 1 1 1 0 Huntingtin protein region DUF2935 PF11155.3 ERZ99766.1 - 0.27 11.3 7.7 0.23 11.5 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) 3Beta_HSD PF01073.14 ERZ99768.1 - 9.4e-14 50.7 0.0 3.9e-07 29.0 0.0 2.2 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ERZ99768.1 - 8.6e-12 44.9 0.0 4e-11 42.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ERZ99768.1 - 4.3e-10 38.9 0.0 1.2e-06 27.6 0.0 2.6 3 0 0 3 3 3 2 RmlD substrate binding domain NAD_binding_10 PF13460.1 ERZ99768.1 - 2e-08 34.4 0.0 2.8e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 ERZ99768.1 - 2.6e-07 29.8 0.1 0.00056 18.9 0.1 3.8 2 1 1 3 3 3 1 Male sterility protein NmrA PF05368.8 ERZ99768.1 - 8.5e-06 25.1 0.0 2.7e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.20 ERZ99768.1 - 0.0094 15.8 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase FHA PF00498.21 ERZ99769.1 - 2.9e-05 24.0 0.0 6.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 FHA domain FLO_LFY PF01698.11 ERZ99769.1 - 7.5 5.2 12.3 14 4.4 8.4 1.5 2 0 0 2 2 2 0 Floricaula / Leafy protein WD40 PF00400.27 ERZ99770.1 - 1.6e-26 91.1 10.6 4.7e-09 35.7 0.3 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 ERZ99770.1 - 1.9e-06 26.4 1.7 0.013 13.8 0.0 3.4 3 1 1 4 4 4 3 Cytochrome D1 heme domain BBS2_Mid PF14783.1 ERZ99770.1 - 0.00049 19.8 0.0 1.5 8.6 0.0 3.3 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.1 ERZ99770.1 - 0.0091 16.2 1.0 7.7 6.9 0.0 3.6 3 0 0 3 3 3 1 PQQ-like domain Nucleoporin_N PF08801.6 ERZ99770.1 - 0.012 14.3 1.5 0.51 9.0 0.1 2.6 1 1 1 2 2 2 0 Nup133 N terminal like Coatomer_WDAD PF04053.9 ERZ99770.1 - 0.016 14.0 0.0 0.02 13.6 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region DUF1480 PF07351.8 ERZ99770.1 - 0.021 14.8 0.1 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1480) Kelch_6 PF13964.1 ERZ99770.1 - 0.032 14.4 2.4 4.9 7.4 0.0 4.0 5 0 0 5 5 5 0 Kelch motif PmrD PF11183.3 ERZ99770.1 - 0.082 12.7 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Polymyxin resistance protein PmrD NAD_binding_2 PF03446.10 ERZ99771.1 - 2e-29 102.5 0.0 2.9e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 ERZ99771.1 - 5.5e-10 39.3 0.0 1.5e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 ERZ99771.1 - 2.7e-06 27.7 0.2 5.5e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 ERZ99771.1 - 6.6e-05 23.0 0.3 0.00011 22.3 0.2 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.14 ERZ99771.1 - 0.0056 15.8 0.1 0.0089 15.1 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SIS PF01380.17 ERZ99771.1 - 0.009 15.6 0.4 1.7 8.2 0.0 3.1 2 1 1 3 3 3 1 SIS domain IlvN PF07991.7 ERZ99771.1 - 0.016 14.5 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Ank_4 PF13637.1 ERZ99772.1 - 7.2e-11 42.2 0.4 4.3e-06 27.0 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ERZ99772.1 - 1.7e-10 40.7 0.0 2.9e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 ERZ99772.1 - 2.8e-09 37.1 0.0 4.7e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ERZ99772.1 - 8.8e-09 34.7 0.0 1.1e-06 28.0 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 ERZ99772.1 - 4.1e-06 26.5 0.0 0.0004 20.3 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat DUF3447 PF11929.3 ERZ99772.1 - 0.0097 15.6 0.0 0.099 12.4 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3447) Pol_alpha_B_N PF08418.5 ERZ99772.1 - 0.092 12.2 2.9 0.12 11.9 2.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal TLD PF07534.11 ERZ99773.1 - 4.9e-12 46.0 2.1 6e-12 45.7 0.4 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99773.1 - 2.2e-07 30.6 0.4 4.7e-06 26.3 0.1 3.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ99773.1 - 2.9e-07 30.4 0.3 7e-07 29.2 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain Tctex-1 PF03645.8 ERZ99774.1 - 0.077 12.8 0.1 0.087 12.6 0.1 1.1 1 0 0 1 1 1 0 Tctex-1 family IPPT PF01715.12 ERZ99774.1 - 0.085 11.8 0.1 0.086 11.8 0.1 1.0 1 0 0 1 1 1 0 IPP transferase BOP1NT PF08145.7 ERZ99775.1 - 5.9e-101 337.5 13.8 8.5e-101 337.0 9.6 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 ERZ99775.1 - 2.2e-32 109.7 12.8 8.4e-12 44.4 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat FBP PF07299.6 ERZ99776.1 - 0.08 12.2 1.4 0.37 10.0 0.3 2.2 1 1 1 2 2 2 0 Fibronectin-binding protein (FBP) Bromodomain PF00439.20 ERZ99777.1 - 1.3e-23 82.7 1.2 1.3e-23 82.7 0.8 2.1 2 0 0 2 2 2 1 Bromodomain Acetyltransf_7 PF13508.1 ERZ99777.1 - 5e-13 49.0 0.4 1.2e-12 47.8 0.3 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ERZ99777.1 - 9.1e-11 41.6 0.1 2.5e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 ERZ99777.1 - 3.3e-07 30.3 3.3 5.6e-07 29.6 0.1 2.8 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ERZ99777.1 - 0.00023 20.8 0.0 0.00049 19.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 ERZ99777.1 - 0.00032 20.7 0.0 0.00073 19.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ERZ99777.1 - 0.0028 17.8 0.0 0.0088 16.2 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ERZ99777.1 - 0.0074 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1247 PF06851.6 ERZ99778.1 - 0.21 11.2 2.2 0.17 11.5 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) Lectin_N PF03954.9 ERZ99778.1 - 0.23 10.8 6.4 0.13 11.7 0.8 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Fib_alpha PF08702.5 ERZ99778.1 - 0.44 10.6 6.2 0.45 10.6 3.5 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family ATP-synt_E PF05680.7 ERZ99778.1 - 1.2 9.1 4.9 0.83 9.6 0.0 2.0 1 1 1 2 2 2 0 ATP synthase E chain OmpH PF03938.9 ERZ99778.1 - 2.6 7.9 11.0 5.5 6.8 7.6 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) KxDL PF10241.4 ERZ99778.1 - 3.9 7.4 8.6 0.51 10.2 2.1 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein TPR_MLP1_2 PF07926.7 ERZ99778.1 - 6.2 6.5 16.4 2.6 7.7 6.2 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.1 ERZ99778.1 - 6.5 6.7 17.9 1.6 8.7 5.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Cu_bind_like PF02298.12 ERZ99780.1 - 3.1e-07 30.0 0.0 5.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Plastocyanin-like domain Copper-bind PF00127.15 ERZ99780.1 - 0.0061 16.7 0.0 0.0082 16.3 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family SoxE PF06525.6 ERZ99780.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) MULE PF10551.4 ERZ99781.1 - 5.3e-07 29.7 0.0 1.7e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 MULE transposase domain FAR1 PF03101.10 ERZ99781.1 - 0.0086 16.5 0.3 0.0086 16.5 0.2 2.3 2 0 0 2 2 2 1 FAR1 DNA-binding domain KSR1-SAM PF13543.1 ERZ99785.1 - 0.04 13.7 1.3 0.044 13.5 0.4 1.4 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 Transposase_21 PF02992.9 ERZ99787.1 - 4.6e-05 22.6 0.0 5.2e-05 22.4 0.0 1.0 1 0 0 1 1 1 1 Transposase family tnp2 Cas_Csd1 PF09709.5 ERZ99788.1 - 0.034 12.4 0.0 0.038 12.2 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csd1) MreB_Mbl PF06723.8 ERZ99789.1 - 5.7e-05 21.8 0.0 0.0046 15.6 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ99789.1 - 0.00011 20.2 0.2 0.00064 17.7 0.0 2.1 2 1 0 2 2 2 1 Hsp70 protein HSP70 PF00012.15 ERZ99790.1 - 2e-05 22.7 0.0 0.00044 18.3 0.0 2.5 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ99790.1 - 0.00011 20.8 0.0 0.0024 16.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ERZ99792.1 - 3.3e-05 22.0 0.0 5.9e-05 21.1 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ERZ99792.1 - 4.1e-05 22.3 0.0 0.0006 18.5 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein AAA PF00004.24 ERZ99793.1 - 1e-56 190.7 0.0 9.4e-40 135.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ERZ99793.1 - 3.3e-11 43.4 0.6 0.00057 20.0 0.1 4.2 2 2 0 2 2 2 2 AAA domain AAA_2 PF07724.9 ERZ99793.1 - 9.9e-10 38.5 0.1 1.4e-05 25.1 0.0 3.8 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ERZ99793.1 - 2.9e-09 37.1 0.2 0.002 18.1 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain AAA_19 PF13245.1 ERZ99793.1 - 1.2e-08 34.5 0.4 0.0024 17.5 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain AAA_5 PF07728.9 ERZ99793.1 - 1.3e-08 34.6 0.4 0.00093 18.9 0.0 3.3 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.8 ERZ99793.1 - 1.7e-08 33.6 0.0 0.0025 16.5 0.0 2.6 2 0 0 2 2 2 2 TIP49 C-terminus RuvB_N PF05496.7 ERZ99793.1 - 2.7e-08 33.1 0.0 0.0038 16.2 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus CDC48_2 PF02933.12 ERZ99793.1 - 3.2e-08 33.0 0.6 4.3e-07 29.4 0.2 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.1 ERZ99793.1 - 3.6e-08 33.3 0.0 0.008 16.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 ERZ99793.1 - 1.3e-07 31.5 0.0 0.011 15.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 ERZ99793.1 - 2.8e-07 31.3 3.3 0.002 18.9 0.2 3.5 3 1 0 3 3 2 2 AAA domain Mg_chelatase PF01078.16 ERZ99793.1 - 7.1e-07 28.5 0.2 0.0094 15.1 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 ERZ99793.1 - 1.1e-06 28.1 0.4 0.046 13.1 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_18 PF13238.1 ERZ99793.1 - 1.4e-06 28.6 1.4 0.0039 17.4 0.1 3.5 3 0 0 3 3 2 2 AAA domain AAA_11 PF13086.1 ERZ99793.1 - 4.5e-06 26.4 0.0 0.061 12.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 ERZ99793.1 - 7.3e-06 26.1 0.0 0.12 12.5 0.0 2.9 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.7 ERZ99793.1 - 8.2e-06 25.5 0.4 0.069 12.7 0.0 3.2 3 0 0 3 3 3 2 NACHT domain Sigma54_activat PF00158.21 ERZ99793.1 - 1e-05 25.1 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.1 ERZ99793.1 - 1e-05 25.0 4.5 0.5 9.7 0.2 4.1 2 2 0 4 4 4 2 AAA domain Zeta_toxin PF06414.7 ERZ99793.1 - 1.2e-05 24.5 0.1 0.045 12.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin ABC_tran PF00005.22 ERZ99793.1 - 1.3e-05 25.4 0.9 0.015 15.5 0.0 3.2 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.11 ERZ99793.1 - 8.8e-05 21.8 0.0 0.27 10.4 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.6 ERZ99793.1 - 0.0001 21.9 0.0 0.077 12.6 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 ERZ99793.1 - 0.0001 21.9 0.5 0.16 11.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain UPF0079 PF02367.12 ERZ99793.1 - 0.00015 21.4 0.0 0.37 10.4 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 KaiC PF06745.8 ERZ99793.1 - 0.00021 20.5 2.5 0.037 13.1 0.0 3.4 3 1 1 4 4 4 1 KaiC AAA_28 PF13521.1 ERZ99793.1 - 0.00032 20.6 0.0 0.6 10.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 ERZ99793.1 - 0.00035 19.6 0.0 0.073 12.0 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 ERZ99793.1 - 0.00042 19.2 0.3 0.77 8.5 0.0 2.9 3 0 0 3 3 3 2 NB-ARC domain DEAD PF00270.24 ERZ99793.1 - 0.0013 18.2 0.4 14 5.1 0.0 4.4 2 2 0 4 4 4 0 DEAD/DEAH box helicase Sigma54_activ_2 PF14532.1 ERZ99793.1 - 0.0016 18.5 0.0 2.2 8.3 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_30 PF13604.1 ERZ99793.1 - 0.0016 18.0 0.0 0.46 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 ERZ99793.1 - 0.0024 17.1 0.0 0.8 8.8 0.0 2.4 2 0 0 2 2 2 1 Chromatin associated protein KTI12 ResIII PF04851.10 ERZ99793.1 - 0.0029 17.4 0.3 3.5 7.4 0.0 3.1 2 2 0 2 2 2 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 ERZ99793.1 - 0.0062 16.0 0.2 0.065 12.6 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family Parvo_NS1 PF01057.12 ERZ99793.1 - 0.0074 15.1 0.0 1.5 7.6 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 CPT PF07931.7 ERZ99793.1 - 0.018 14.6 0.0 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Torsin PF06309.6 ERZ99793.1 - 0.027 14.3 0.1 8.1 6.3 0.0 3.0 3 0 0 3 3 2 0 Torsin DAP3 PF10236.4 ERZ99793.1 - 0.03 13.2 0.3 1 8.2 0.0 2.6 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 T2SE PF00437.15 ERZ99793.1 - 0.038 12.8 0.0 5.8 5.7 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.1 ERZ99793.1 - 0.063 12.8 0.1 4 7.0 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zot PF05707.7 ERZ99793.1 - 0.063 12.7 0.1 8.3 5.8 0.0 2.6 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Cofilin_ADF PF00241.15 ERZ99794.1 - 2.9e-38 130.6 2.4 3.3e-38 130.4 1.7 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Peptidase_S48 PF03574.10 ERZ99794.1 - 0.085 12.8 0.0 0.13 12.2 0.0 1.3 1 1 0 1 1 1 0 Peptidase family S48 TLD PF07534.11 ERZ99796.1 - 9e-11 41.9 1.4 1.3e-10 41.4 1.0 1.2 1 0 0 1 1 1 1 TLD BTB PF00651.26 ERZ99796.1 - 1.1e-06 28.5 0.1 2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain F-box-like PF12937.2 ERZ99797.1 - 0.018 14.7 0.5 0.051 13.2 0.3 1.8 1 0 0 1 1 1 0 F-box-like NYN PF01936.13 ERZ99798.1 - 0.00051 20.3 0.0 0.0021 18.3 0.0 2.0 1 1 0 1 1 1 1 NYN domain SAM_2 PF07647.12 ERZ99798.1 - 0.00058 19.6 0.4 0.0014 18.4 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ERZ99798.1 - 0.00099 19.2 0.0 0.0023 18.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MIR PF02815.14 ERZ99799.1 - 0.0043 16.6 0.3 0.0065 16.0 0.2 1.3 1 0 0 1 1 1 1 MIR domain TRCF PF03461.10 ERZ99799.1 - 0.062 13.2 0.1 5.6 6.9 0.0 2.5 2 1 0 2 2 2 0 TRCF domain UBN2_2 PF14227.1 ERZ99799.1 - 0.26 10.8 1.7 8.9 5.9 0.1 2.8 1 1 2 3 3 3 0 gag-polypeptide of LTR copia-type MIR PF02815.14 ERZ99800.1 - 0.0097 15.4 0.0 0.03 13.8 0.0 1.8 1 0 0 1 1 1 1 MIR domain TRCF PF03461.10 ERZ99800.1 - 0.016 15.1 0.3 1.9 8.4 0.0 2.9 1 1 1 2 2 2 0 TRCF domain DUF987 PF06174.6 ERZ99800.1 - 0.14 11.6 0.1 0.29 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF987) MIR PF02815.14 ERZ99801.1 - 0.014 14.9 0.1 0.1 12.1 0.0 2.0 1 1 1 2 2 2 0 MIR domain ASXH PF13919.1 ERZ99801.1 - 0.09 12.5 0.4 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Asx homology domain Ins145_P3_rec PF08709.6 ERZ99801.1 - 0.091 11.7 0.1 0.84 8.6 0.0 2.2 1 1 1 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Ins145_P3_rec PF08709.6 ERZ99802.1 - 4.5e-07 29.1 0.3 0.0075 15.3 0.2 2.1 1 1 1 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ERZ99802.1 - 0.028 13.9 0.4 0.22 11.0 0.0 2.4 3 0 0 3 3 3 0 MIR domain TDH PF03347.8 ERZ99803.1 - 0.0043 16.6 1.9 0.0043 16.6 1.3 2.3 1 1 1 2 2 2 1 Vibrio thermostable direct hemolysin MIR PF02815.14 ERZ99803.1 - 0.015 14.8 1.7 0.21 11.1 1.2 2.2 1 1 0 1 1 1 0 MIR domain F-box-like PF12937.2 ERZ99805.1 - 8.5e-12 44.6 12.3 1.4e-06 27.8 0.5 4.4 4 0 0 4 4 4 2 F-box-like F-box PF00646.28 ERZ99805.1 - 0.019 14.6 11.2 0.17 11.5 0.1 5.1 5 0 0 5 5 5 0 F-box domain AAA_12 PF13087.1 ERZ99807.1 - 9.9e-37 126.2 3.2 9.9e-37 126.2 2.2 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ERZ99807.1 - 3.8e-28 98.6 0.0 3.8e-28 98.6 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.1 ERZ99807.1 - 1.1e-06 28.2 0.0 2.6e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ERZ99807.1 - 6.3e-05 22.6 0.0 0.014 14.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 ERZ99807.1 - 0.00026 20.0 0.0 0.00026 20.0 0.0 4.1 5 0 0 5 5 5 1 Uncharacterized conserved protein (DUF2075) zf-NF-X1 PF01422.12 ERZ99807.1 - 0.00063 19.6 12.0 0.00063 19.6 8.3 7.1 6 0 0 6 6 6 1 NF-X1 type zinc finger AAA_16 PF13191.1 ERZ99807.1 - 0.048 13.6 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain UvrD_C_2 PF13538.1 ERZ99807.1 - 0.053 13.6 0.8 0.17 12.0 0.0 2.4 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA PF00004.24 ERZ99807.1 - 0.29 11.3 2.6 6 7.0 0.7 3.8 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 ERZ99808.1 - 4.1e-08 33.5 0.0 0.0011 19.2 0.0 3.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ERZ99808.1 - 1.1e-06 28.4 0.0 0.00021 21.0 0.0 3.8 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) CBM_20 PF00686.14 ERZ99808.1 - 1.5e-05 24.4 0.0 5e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 Starch binding domain AAA_22 PF13401.1 ERZ99808.1 - 0.009 16.1 0.0 0.62 10.2 0.0 3.5 2 0 0 2 2 2 1 AAA domain zf-RING_4 PF14570.1 ERZ99808.1 - 0.033 13.7 1.1 0.12 12.0 0.8 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain AAA_16 PF13191.1 ERZ99808.1 - 0.042 13.8 0.0 8.8 6.2 0.0 3.2 2 0 0 2 2 2 0 AAA ATPase domain HMG_box PF00505.14 ERZ99810.1 - 1.4e-08 34.8 0.7 3.6e-08 33.5 0.5 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99810.1 - 0.00077 19.7 0.4 0.0022 18.3 0.3 1.7 1 0 0 1 1 1 1 HMG-box domain DUF4519 PF15012.1 ERZ99810.1 - 1.9 8.4 5.8 26 4.8 1.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) HGD-D PF06050.8 ERZ99811.1 - 0.077 11.8 0.0 0.087 11.6 0.0 1.0 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Sel1 PF08238.7 ERZ99812.1 - 6.2e-70 230.1 21.4 1.5e-11 44.5 0.5 7.5 8 0 0 8 8 8 7 Sel1 repeat DUF2235 PF09994.4 ERZ99812.1 - 0.39 10.0 8.1 7 5.9 0.0 3.8 1 1 4 5 5 5 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Dimer_Tnp_hAT PF05699.9 ERZ99813.1 - 1.4e-05 24.6 0.1 4.2e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TSC22 PF01166.13 ERZ99815.1 - 1.9e-07 30.9 55.7 0.39 10.7 0.7 9.2 5 2 4 9 9 9 6 TSC-22/dip/bun family CENP-F_leu_zip PF10473.4 ERZ99815.1 - 4.4e-05 23.3 32.1 0.0077 16.0 2.6 5.5 1 1 3 5 5 5 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CCDC155 PF14662.1 ERZ99815.1 - 0.0004 20.0 7.1 0.0004 20.0 4.9 4.7 2 1 1 4 4 4 1 Coiled-coil region of CCDC155 DUF904 PF06005.7 ERZ99815.1 - 0.00049 20.3 52.0 0.49 10.7 0.1 7.5 1 1 6 7 7 7 4 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ERZ99815.1 - 0.0015 18.4 45.2 0.038 13.9 1.8 8.1 5 3 4 10 10 10 3 bZIP transcription factor IncA PF04156.9 ERZ99815.1 - 0.0047 16.5 14.2 0.91 9.0 0.8 4.2 1 1 2 4 4 4 2 IncA protein Filament PF00038.16 ERZ99815.1 - 0.014 14.9 1.4 0.014 14.9 1.0 4.7 1 1 4 5 5 5 0 Intermediate filament protein DUF972 PF06156.8 ERZ99815.1 - 0.028 14.7 45.7 4.9 7.5 2.4 7.3 1 1 6 7 7 7 0 Protein of unknown function (DUF972) DUF4315 PF14193.1 ERZ99815.1 - 0.059 13.2 0.4 0.059 13.2 0.3 5.2 3 2 2 5 5 5 0 Domain of unknown function (DUF4315) Pox_A_type_inc PF04508.7 ERZ99815.1 - 0.081 12.7 2.9 0.28 11.0 0.1 3.6 4 0 0 4 4 2 0 Viral A-type inclusion protein repeat DUF3450 PF11932.3 ERZ99815.1 - 1.1 8.5 15.3 0.35 10.0 1.7 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DivIC PF04977.10 ERZ99815.1 - 1.2 8.6 47.5 1 8.8 0.8 8.6 5 5 4 10 10 10 0 Septum formation initiator DUF4618 PF15397.1 ERZ99815.1 - 1.2 8.3 32.3 0.074 12.3 1.5 5.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) TMF_TATA_bd PF12325.3 ERZ99815.1 - 5.9 6.6 26.8 1.5 8.6 0.2 5.0 1 1 4 5 5 5 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 ERZ99815.1 - 6.5 6.6 41.0 0.53 10.1 3.6 6.4 5 2 0 6 6 6 0 TATA element modulatory factor 1 DNA binding Rootletin PF15035.1 ERZ99815.1 - 7 6.5 27.4 0.52 10.2 1.4 4.5 1 1 2 4 4 4 0 Ciliary rootlet component, centrosome cohesion MFS_1 PF07690.11 ERZ99817.1 - 0.00092 18.0 2.9 0.001 17.8 2.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ERZ99817.1 - 0.21 10.1 6.6 0.24 9.9 4.6 1.2 1 0 0 1 1 1 0 Sugar (and other) transporter Tic20 PF09685.5 ERZ99817.1 - 0.26 11.2 3.1 0.3 11.0 2.2 1.2 1 1 0 1 1 1 0 Tic20-like protein AIG1 PF04548.11 ERZ99818.1 - 3.9e-21 75.1 0.1 3.9e-21 75.1 0.0 3.0 1 1 3 4 4 4 1 AIG1 family MMR_HSR1 PF01926.18 ERZ99818.1 - 0.00041 20.2 0.0 0.0018 18.2 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ99818.1 - 0.041 13.6 0.0 0.041 13.6 0.0 4.0 2 1 0 2 2 2 0 Dynamin family KID PF02524.9 ERZ99818.1 - 0.14 12.3 2.2 9.7 6.8 0.6 3.3 2 0 0 2 2 2 0 KID repeat PLRV_ORF5 PF01690.12 ERZ99818.1 - 7.2 5.6 24.1 10 5.1 16.7 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Hint PF01079.15 ERZ99819.1 - 2.4e-16 59.6 0.0 3.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Hint module RNase_H PF00075.19 ERZ99820.1 - 8.3e-09 35.8 5.0 1.3e-07 32.0 1.9 2.9 2 1 0 2 2 2 1 RNase H SNARE_assoc PF09335.6 ERZ99821.1 - 1.8e-14 54.0 0.7 1.1e-13 51.4 0.1 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein UPF0104 PF03706.8 ERZ99821.1 - 0.0035 16.6 0.6 0.0035 16.6 0.4 2.0 1 1 0 2 2 2 1 Uncharacterised protein family (UPF0104) MscS_TM PF12794.2 ERZ99821.1 - 0.052 12.1 5.5 1.7 7.1 1.1 2.3 2 1 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 S1FA PF04689.8 ERZ99821.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.4 2 1 0 2 2 2 0 DNA binding protein S1FA Colicin_V PF02674.11 ERZ99821.1 - 0.31 10.8 8.7 4.5 7.1 2.9 2.4 2 1 0 2 2 2 0 Colicin V production protein IL34 PF15036.1 ERZ99822.1 - 0.013 15.1 0.2 0.016 14.8 0.1 1.1 1 0 0 1 1 1 0 Interleukin 34 Ovate PF04844.8 ERZ99822.1 - 0.12 12.1 0.6 0.26 11.1 0.4 1.5 1 0 0 1 1 1 0 Transcriptional repressor, ovate BTB PF00651.26 ERZ99825.1 - 1.1e-20 73.6 0.4 4e-20 71.8 0.3 2.0 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ERZ99825.1 - 9.4e-05 22.1 0.5 0.00046 19.9 0.1 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Tn916-Xis PF09035.5 ERZ99825.1 - 0.078 13.0 0.0 1.8 8.6 0.0 2.8 3 0 0 3 3 3 0 Excisionase from transposon Tn916 Pkinase_Tyr PF07714.12 ERZ99826.1 - 9.9e-35 119.8 0.3 1.8e-34 118.9 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99826.1 - 2.4e-30 105.5 0.8 4.5e-30 104.6 0.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ERZ99826.1 - 4.8e-08 33.3 5.5 1.7e-06 28.4 0.0 3.9 4 0 0 4 4 4 1 Sel1 repeat Imm22 PF15592.1 ERZ99829.1 - 0.0017 18.6 0.3 0.003 17.8 0.1 1.5 1 1 0 1 1 1 1 Immunity protein 22 CDC37_N PF03234.9 ERZ99829.1 - 0.0031 17.8 6.4 0.0036 17.6 4.4 1.1 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding DUF4375 PF14300.1 ERZ99829.1 - 0.005 16.8 2.1 0.0079 16.1 1.4 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4375) Ribos_L4_asso_C PF14374.1 ERZ99829.1 - 0.011 15.5 0.9 0.14 12.0 0.6 2.2 1 1 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain DUF2458 PF10454.4 ERZ99829.1 - 0.061 13.2 6.6 0.067 13.0 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Latarcin PF10279.4 ERZ99829.1 - 0.13 12.5 6.4 0.17 12.1 4.5 1.3 1 0 0 1 1 1 0 Latarcin precursor DUF1690 PF07956.6 ERZ99829.1 - 0.14 12.0 8.1 0.17 11.8 5.6 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) ORF6C PF10552.4 ERZ99829.1 - 2.6 7.8 6.2 0.84 9.3 2.2 1.7 2 0 0 2 2 2 0 ORF6C domain LRR_4 PF12799.2 ERZ99829.1 - 3.2 7.4 7.2 11 5.7 0.1 2.5 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) AAA_23 PF13476.1 ERZ99829.1 - 6.7 6.9 10.6 7.7 6.7 7.4 1.1 1 0 0 1 1 1 0 AAA domain MULE PF10551.4 ERZ99830.1 - 1.4e-11 44.3 1.5 1.1e-10 41.4 0.0 2.5 2 0 0 2 2 2 1 MULE transposase domain FAR1 PF03101.10 ERZ99830.1 - 1.3e-09 38.4 2.1 1.3e-09 38.4 1.4 1.9 2 0 0 2 2 2 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ERZ99830.1 - 1.5e-05 24.5 0.9 0.0019 17.7 0.0 2.8 2 0 0 2 2 2 1 MuDR family transposase Scm3 PF10384.4 ERZ99830.1 - 0.016 14.6 0.1 0.92 9.0 0.0 2.5 2 0 0 2 2 2 0 Centromere protein Scm3 Tricorn_C1 PF14684.1 ERZ99830.1 - 0.018 14.9 0.6 0.9 9.4 0.1 3.0 2 1 1 3 3 3 0 Tricorn protease C1 domain Drf_FH1 PF06346.7 ERZ99832.1 - 0.015 14.8 10.3 0.018 14.5 7.2 1.1 1 0 0 1 1 1 0 Formin Homology Region 1 MULE PF10551.4 ERZ99833.1 - 3.4e-07 30.3 0.0 6.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain BTB PF00651.26 ERZ99834.1 - 3.3e-19 68.9 0.3 2.7e-18 65.9 0.0 2.5 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ERZ99834.1 - 1.9e-11 44.1 2.0 1.9e-11 44.1 1.4 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99834.1 - 5.8e-09 35.7 0.1 2.2e-07 30.6 0.1 3.2 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ERZ99834.1 - 0.0029 16.8 0.3 0.0059 15.7 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) BTB_2 PF02214.17 ERZ99834.1 - 0.037 14.2 0.1 0.12 12.5 0.0 1.9 1 1 0 1 1 1 0 BTB/POZ domain BTB PF00651.26 ERZ99835.1 - 1.4e-15 57.2 0.5 3e-15 56.1 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ99835.1 - 0.00025 20.8 0.5 0.12 12.2 0.2 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch STAS PF01740.16 ERZ99835.1 - 0.022 14.1 0.1 0.095 12.1 0.0 2.1 2 0 0 2 2 2 0 STAS domain SWIM PF04434.12 ERZ99836.1 - 1.4e-05 24.4 0.9 2.5e-05 23.6 0.6 1.5 1 0 0 1 1 1 1 SWIM zinc finger Carboxyl_trans PF01039.17 ERZ99836.1 - 0.18 10.0 0.3 0.23 9.7 0.2 1.1 1 0 0 1 1 1 0 Carboxyl transferase domain Glyco_transf_49 PF13896.1 ERZ99840.1 - 4.6e-11 42.3 1.3 2.4e-10 40.0 0.7 1.9 1 1 1 2 2 2 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.21 ERZ99840.1 - 0.042 13.5 0.0 0.082 12.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Methyltransf_31 PF13847.1 ERZ99841.1 - 1.9e-11 43.7 0.2 7.1e-11 41.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 ERZ99841.1 - 3.5e-10 39.1 2.5 5.4e-10 38.4 0.1 2.4 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_26 PF13659.1 ERZ99841.1 - 1e-06 28.7 0.0 2.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ERZ99841.1 - 4.3e-06 27.2 0.0 1.4e-05 25.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ERZ99841.1 - 6.5e-06 25.6 0.1 3.6e-05 23.2 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase small domain PrmA PF06325.8 ERZ99841.1 - 1.3e-05 24.5 2.1 3.3e-05 23.1 0.0 2.4 3 0 0 3 3 3 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 ERZ99841.1 - 8.6e-05 22.8 0.0 0.00044 20.5 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ERZ99841.1 - 8.9e-05 21.7 0.0 0.00046 19.3 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 ERZ99841.1 - 0.00015 21.4 0.6 0.00057 19.5 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain RRM_1 PF00076.17 ERZ99841.1 - 0.00058 19.4 0.2 0.0039 16.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cons_hypoth95 PF03602.10 ERZ99841.1 - 0.0033 16.8 0.0 0.0076 15.6 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_4 PF02390.12 ERZ99841.1 - 0.015 14.3 0.9 0.029 13.3 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_11 PF08241.7 ERZ99841.1 - 0.021 15.2 0.0 0.083 13.3 0.0 2.1 2 0 0 2 2 1 0 Methyltransferase domain UPF0020 PF01170.13 ERZ99841.1 - 0.023 14.2 0.2 0.1 12.1 0.1 2.1 1 1 1 2 2 2 0 Putative RNA methylase family UPF0020 UDPG_MGDP_dh_N PF03721.9 ERZ99841.1 - 0.041 13.2 0.1 0.083 12.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RFC1 PF08519.7 ERZ99842.1 - 1.2e-12 47.8 0.8 1.5e-12 47.5 0.6 1.2 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain DUF1633 PF07794.6 ERZ99842.1 - 0.11 10.3 0.1 0.14 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Yqai PF09466.5 ERZ99842.1 - 0.48 10.4 4.0 0.28 11.1 0.8 1.9 2 0 0 2 2 2 0 Hypothetical protein Yqai DASH_Duo1 PF08651.5 ERZ99843.1 - 0.14 11.7 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 Hint PF01079.15 ERZ99845.1 - 2.2e-21 76.0 0.1 3.8e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Hint module MIP-T3 PF10243.4 ERZ99845.1 - 0.4 9.0 50.3 0.52 8.7 34.9 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 LMBR1 PF04791.11 ERZ99845.1 - 2.9 6.3 6.5 3.2 6.2 4.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Ldh_1_N PF00056.18 ERZ99847.1 - 6.8e-37 126.4 1.1 1.3e-36 125.5 0.8 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 ERZ99847.1 - 1.2e-29 103.2 0.1 2.6e-29 102.1 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain ApbA PF02558.11 ERZ99847.1 - 0.0016 17.8 0.6 0.0038 16.6 0.4 1.8 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 ERZ99847.1 - 0.012 14.9 3.1 0.13 11.6 2.1 2.1 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.13 ERZ99847.1 - 0.019 14.6 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 ERZ99847.1 - 0.061 13.1 0.4 0.14 11.9 0.2 1.7 2 0 0 2 2 2 0 ThiF family Shikimate_DH PF01488.15 ERZ99847.1 - 0.062 13.4 1.1 0.2 11.7 0.8 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RINGv PF12906.2 ERZ99850.1 - 8.6e-16 57.7 9.4 1.5e-15 56.9 6.5 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING-like PF08746.6 ERZ99850.1 - 9.5 6.3 9.1 22 5.1 6.3 1.6 1 0 0 1 1 1 0 RING-like domain RAB3GAP2_C PF14656.1 ERZ99852.1 - 1.6e-17 62.8 0.4 3.6e-17 61.7 0.3 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus RAB3GAP2_N PF14655.1 ERZ99853.1 - 1.3e-71 241.8 0.0 1.9e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus HTH_29 PF13551.1 ERZ99854.1 - 6.9e-05 22.9 0.0 0.00012 22.1 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 ERZ99854.1 - 0.00014 21.8 0.1 0.0059 16.6 0.0 2.1 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.1 ERZ99854.1 - 0.0023 18.6 0.0 0.0034 18.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain Phage_NinH PF06322.6 ERZ99854.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Phage NinH protein PDDEXK_5 PF11645.3 ERZ99855.1 - 0.14 11.8 0.1 0.15 11.7 0.1 1.1 1 0 0 1 1 1 0 PD-(D/E)XK endonuclease LRR_6 PF13516.1 ERZ99856.1 - 5.7e-13 47.4 5.8 0.008 16.1 0.0 6.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_8 PF13855.1 ERZ99856.1 - 5.8e-09 35.5 1.0 1.7e-05 24.4 0.0 4.3 2 2 2 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 ERZ99856.1 - 0.00019 20.9 8.8 0.21 11.2 0.0 4.3 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ERZ99856.1 - 0.0011 18.7 9.1 6.6 7.1 0.0 6.1 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 ERZ99856.1 - 0.0013 18.5 3.8 63 4.4 0.0 5.6 4 1 0 4 4 4 0 Leucine rich repeat DUF4304 PF14137.1 ERZ99856.1 - 0.087 12.9 0.1 0.19 11.8 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4304) Herpes_PAP PF03325.8 ERZ99858.1 - 0.056 12.9 0.4 0.14 11.6 0.3 1.6 1 1 0 1 1 1 0 Herpesvirus polymerase accessory protein Laps PF10169.4 ERZ99858.1 - 1.4 9.1 6.3 0.62 10.2 2.2 1.7 1 1 1 2 2 2 0 Learning-associated protein LRR_6 PF13516.1 ERZ99859.1 - 3.5e-14 51.2 8.7 0.012 15.5 0.0 8.0 9 0 0 9 9 9 4 Leucine Rich repeat LRR_8 PF13855.1 ERZ99859.1 - 6.1e-12 45.1 5.3 0.0089 15.7 0.1 4.7 3 2 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 ERZ99859.1 - 2.9e-09 36.3 5.0 0.0034 16.9 0.0 5.5 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ERZ99859.1 - 1.1e-06 27.8 0.7 47 4.8 0.2 7.3 7 2 1 8 8 8 0 Leucine rich repeat LRR_1 PF00560.28 ERZ99859.1 - 3e-06 26.4 9.4 0.93 9.7 0.2 7.4 7 2 0 7 7 7 1 Leucine Rich Repeat HMG_box PF00505.14 ERZ99860.1 - 1.4e-06 28.4 0.0 2.1e-06 27.8 0.0 1.3 1 1 0 1 1 1 1 HMG (high mobility group) box SAM_1 PF00536.25 ERZ99861.1 - 0.022 14.9 0.1 0.2 11.8 0.0 2.6 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) AAA PF00004.24 ERZ99861.1 - 0.031 14.4 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TLD PF07534.11 ERZ99864.1 - 4.8e-10 39.5 2.5 4.3e-09 36.4 1.1 2.6 2 1 0 2 2 2 1 TLD BACK PF07707.10 ERZ99864.1 - 0.0012 18.6 4.5 0.013 15.3 0.6 3.0 1 1 3 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ERZ99864.1 - 0.072 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain DEAD PF00270.24 ERZ99865.1 - 3e-39 134.2 2.0 7.6e-39 132.9 0.1 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ERZ99865.1 - 1.1e-21 76.4 0.0 2.9e-21 75.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ERZ99865.1 - 1.4e-21 75.8 0.2 2.9e-21 74.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.1 ERZ99865.1 - 0.0039 17.3 0.5 0.038 14.1 0.1 2.8 2 1 0 2 2 2 1 AAA domain TPP1 PF10341.4 ERZ99866.1 - 3.7e-11 42.9 0.5 5.7e-11 42.3 0.3 1.4 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DUF2109 PF09882.4 ERZ99868.1 - 2.3 8.1 10.8 5.2 7.0 1.9 3.2 3 1 0 3 3 3 0 Predicted membrane protein (DUF2109) PEPcase_2 PF14010.1 ERZ99869.1 - 0.3 9.3 3.4 0.13 10.5 0.4 1.7 1 1 1 2 2 2 0 Phosphoenolpyruvate carboxylase RNA_pol_Rpb1_5 PF04998.12 ERZ99869.1 - 0.63 9.2 6.7 0.83 8.8 4.6 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 IFN-gamma PF00714.12 ERZ99869.1 - 2.2 8.0 16.7 0.25 11.1 1.0 2.9 1 1 2 3 3 3 0 Interferon gamma Pkinase PF00069.20 ERZ99871.1 - 4e-13 49.1 0.7 4.1e-13 49.0 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99871.1 - 2.2e-07 30.2 0.2 2.4e-07 30.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ERZ99871.1 - 9.6e-06 25.4 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ERZ99871.1 - 1.2e-05 24.7 0.2 1.3e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ERZ99871.1 - 2.8e-05 23.8 0.4 3.4e-05 23.5 0.3 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.9 ERZ99871.1 - 0.00099 18.2 0.3 0.001 18.2 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ERZ99871.1 - 0.0021 17.0 0.0 0.0023 16.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 ERZ99871.1 - 0.0037 16.5 0.6 0.0037 16.5 0.4 1.0 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Pox_ser-thr_kin PF05445.6 ERZ99871.1 - 0.011 14.5 0.5 0.013 14.2 0.4 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 ERZ99871.1 - 0.019 13.8 0.0 0.02 13.7 0.0 1.0 1 0 0 1 1 1 0 Seadornavirus VP7 PIP49_C PF12260.3 ERZ99871.1 - 0.085 12.2 0.1 0.093 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 HSDR_N_2 PF13588.1 ERZ99872.1 - 0.049 13.4 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Sel1 PF08238.7 ERZ99873.1 - 1.4e-55 184.4 15.0 5.9e-12 45.8 0.2 6.0 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ERZ99873.1 - 0.0028 17.9 4.1 4.7 7.8 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF1134 PF06577.7 ERZ99873.1 - 0.081 12.4 2.1 2.9 7.3 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1134) TPR_11 PF13414.1 ERZ99873.1 - 0.29 10.8 17.7 0.55 9.9 1.2 3.9 2 1 0 3 3 3 0 TPR repeat MIT PF04212.13 ERZ99873.1 - 8.7 6.3 13.8 8 6.4 0.3 5.1 4 1 2 6 6 6 0 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.12 ERZ99874.1 - 1.4e-19 70.2 0.5 2.5e-19 69.3 0.3 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99874.1 - 4e-19 68.7 0.9 7.4e-19 67.9 0.3 1.7 1 1 0 1 1 1 1 Protein kinase domain UL73_N PF12522.3 ERZ99874.1 - 2.8 7.5 6.3 6 6.5 4.4 1.5 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein N terminal RTBV_P12 PF06361.6 ERZ99875.1 - 0.047 13.9 0.1 0.083 13.1 0.1 1.4 1 0 0 1 1 1 0 Rice tungro bacilliform virus P12 protein Opy2 PF09463.5 ERZ99875.1 - 0.11 12.6 1.7 0.17 11.9 1.2 1.3 1 0 0 1 1 1 0 Opy2 protein FTH PF01827.22 ERZ99878.1 - 0.048 13.2 1.2 0.072 12.6 0.9 1.4 1 0 0 1 1 1 0 FTH domain HMG_box PF00505.14 ERZ99880.1 - 1e-10 41.7 0.0 1.9e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99880.1 - 0.00044 20.5 0.3 0.00088 19.5 0.2 1.5 1 0 0 1 1 1 1 HMG-box domain NodZ PF05830.6 ERZ99880.1 - 0.02 13.5 0.0 0.036 12.6 0.0 1.4 1 1 0 1 1 1 0 Nodulation protein Z (NodZ) BTB PF00651.26 ERZ99881.1 - 1.2e-20 73.5 0.6 3.9e-20 71.8 0.4 2.0 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ99881.1 - 2.4e-14 53.0 0.1 7.1e-10 38.6 0.0 3.1 3 0 0 3 3 3 2 BTB And C-terminal Kelch MATH PF00917.21 ERZ99881.1 - 0.008 16.4 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 MATH domain DER1 PF04511.10 ERZ99882.1 - 6.5e-52 175.9 10.0 7.6e-52 175.6 6.9 1.0 1 0 0 1 1 1 1 Der1-like family Clathrin PF00637.15 ERZ99883.1 - 1.5e-25 89.5 1.8 1.5e-25 89.5 1.2 3.3 3 0 0 3 3 3 1 Region in Clathrin and VPS WD40 PF00400.27 ERZ99883.1 - 6e-05 22.7 0.1 0.0014 18.3 0.0 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat Vps39_2 PF10367.4 ERZ99883.1 - 0.00025 21.1 0.0 0.00062 19.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.2 ERZ99883.1 - 0.0014 18.6 0.8 0.0043 17.1 0.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ERZ99883.1 - 0.0032 17.2 2.7 0.014 15.2 1.9 2.0 1 1 1 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 ERZ99883.1 - 0.0044 16.7 1.0 0.0097 15.6 0.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Vps39_1 PF10366.4 ERZ99883.1 - 0.024 14.6 0.3 0.12 12.3 0.0 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 zf-C3HC4 PF00097.20 ERZ99883.1 - 0.32 10.6 5.3 0.3 10.7 0.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ERZ99883.1 - 0.76 9.8 5.5 2.5 8.1 0.9 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ERZ99883.1 - 2.8 7.6 4.5 25 4.6 3.1 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HMG_box PF00505.14 ERZ99884.1 - 2.2e-20 72.6 5.8 2.6e-20 72.4 4.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ERZ99884.1 - 4.6e-18 65.3 7.0 5.1e-18 65.2 4.9 1.0 1 0 0 1 1 1 1 HMG-box domain DUF4355 PF14265.1 ERZ99884.1 - 0.078 12.9 2.3 0.1 12.5 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) FAD_binding_3 PF01494.14 ERZ99885.1 - 9.8e-19 67.6 0.0 2.2e-18 66.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain SE PF08491.5 ERZ99885.1 - 9e-05 21.4 0.0 0.0021 16.9 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase DAO PF01266.19 ERZ99885.1 - 0.00023 20.1 0.2 0.00044 19.2 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 ERZ99885.1 - 0.00057 20.2 0.1 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ERZ99885.1 - 0.0018 18.2 0.0 0.0045 16.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 ERZ99885.1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 ERZ99885.1 - 0.19 10.5 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Mob1_phocein PF03637.12 ERZ99888.1 - 1.4e-66 223.4 3.3 1.7e-66 223.2 2.3 1.0 1 0 0 1 1 1 1 Mob1/phocein family Chromo PF00385.19 ERZ99889.1 - 1e-10 41.0 0.3 1.2e-10 40.9 0.2 1.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AIG1 PF04548.11 ERZ99891.1 - 2e-34 118.5 0.1 2e-34 118.5 0.1 3.2 1 1 3 4 4 2 1 AIG1 family MMR_HSR1 PF01926.18 ERZ99891.1 - 4e-11 42.8 0.1 2e-10 40.6 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ERZ99891.1 - 1.7e-07 30.5 0.0 4.2e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ERZ99891.1 - 0.00018 20.8 0.0 0.00034 19.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.22 ERZ99891.1 - 0.0034 17.6 0.0 0.0034 17.6 0.0 3.2 2 1 0 2 2 1 1 ABC transporter AAA_18 PF13238.1 ERZ99891.1 - 0.011 16.0 0.2 0.011 16.0 0.1 4.1 2 2 0 2 2 1 0 AAA domain AAA_33 PF13671.1 ERZ99891.1 - 0.012 15.5 0.0 0.012 15.5 0.0 3.6 2 2 0 2 2 1 0 AAA domain AAA_29 PF13555.1 ERZ99891.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ERZ99891.1 - 0.017 15.2 0.0 0.017 15.2 0.0 2.4 2 1 0 2 2 1 0 AAA domain Miro PF08477.8 ERZ99891.1 - 0.088 13.3 0.0 0.088 13.3 0.0 3.0 2 1 1 3 3 2 0 Miro-like protein AAA_17 PF13207.1 ERZ99891.1 - 0.097 13.4 0.1 0.097 13.4 0.0 3.4 2 2 0 2 2 1 0 AAA domain AAA_16 PF13191.1 ERZ99891.1 - 0.1 12.5 0.0 0.1 12.5 0.0 2.7 2 1 0 2 2 1 0 AAA ATPase domain DUF87 PF01935.12 ERZ99891.1 - 0.9 9.3 0.1 0.9 9.3 0.0 3.4 2 1 1 3 3 2 0 Domain of unknown function DUF87 AAA_10 PF12846.2 ERZ99891.1 - 9.2 5.5 22.8 1.8e+03 -2.0 15.8 2.2 1 1 0 1 1 1 0 AAA-like domain DDA1 PF10172.4 ERZ99892.1 - 0.0051 16.6 0.3 2.6 7.9 0.2 2.6 2 0 0 2 2 2 2 Det1 complexing ubiquitin ligase GST_C PF00043.20 ERZ99893.1 - 1.6e-06 28.0 0.0 1.8e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ERZ99893.1 - 0.00052 19.8 0.1 0.00061 19.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ERZ99894.1 - 7.7e-14 51.4 0.0 1e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ERZ99894.1 - 4e-13 49.3 0.0 9.7e-13 48.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ERZ99894.1 - 1.7e-10 40.9 0.0 3e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ERZ99894.1 - 1.8e-08 34.1 0.0 2.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ERZ99894.1 - 3.6e-07 30.0 0.0 6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Nsp1_C PF05064.8 ERZ99894.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Nsp1-like C-terminal region Polysacc_deac_1 PF01522.16 ERZ99895.1 - 0.046 13.3 0.0 0.91 9.1 0.0 2.6 3 0 0 3 3 3 0 Polysaccharide deacetylase T2SI PF02501.12 ERZ99895.1 - 0.077 12.9 0.2 0.21 11.5 0.1 1.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein I GPI2 PF06432.6 ERZ99898.1 - 0.015 14.6 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase zf-rbx1 PF12678.2 ERZ99898.1 - 0.07 13.2 0.8 0.19 11.8 0.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger AAA_35 PF14516.1 ERZ99899.1 - 0.0018 16.9 0.2 0.0034 16.0 0.1 1.3 1 1 0 1 1 1 1 AAA-like domain Arch_ATPase PF01637.13 ERZ99899.1 - 0.031 13.9 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase DUF2986 PF11661.3 ERZ99901.1 - 0.14 12.4 0.0 0.14 12.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2986) Pkinase_Tyr PF07714.12 ERZ99902.1 - 3.7e-35 121.2 0.0 4e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99902.1 - 1.2e-33 116.3 0.3 1.3e-33 116.2 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ERZ99902.1 - 7.5e-05 21.8 0.2 8.9e-05 21.6 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ERZ99902.1 - 0.0052 16.1 1.2 0.0061 15.9 0.9 1.1 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ERZ99902.1 - 0.011 15.0 0.2 0.014 14.7 0.1 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ERZ99902.1 - 0.016 14.9 0.3 0.019 14.6 0.2 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ERZ99902.1 - 0.025 13.7 0.1 0.031 13.4 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ERZ99903.1 - 4.9e-13 49.2 7.6 2.4e-06 28.0 0.3 3.3 3 1 0 3 3 3 2 Sel1 repeat YkuI_C PF10388.4 ERZ99903.1 - 0.17 11.5 0.7 0.19 11.4 0.5 1.0 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain Pkinase PF00069.20 ERZ99909.1 - 2.1e-20 72.9 0.1 8.4e-11 41.5 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99909.1 - 3.3e-15 55.8 0.1 2.3e-07 30.1 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Cullin PF00888.17 ERZ99909.1 - 7.3e-06 24.8 0.1 1.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Cullin family Beta_elim_lyase PF01212.16 ERZ99909.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase p450 PF00067.17 ERZ99910.1 - 1.6e-17 63.2 0.5 8e-17 60.9 0.3 1.8 1 1 0 1 1 1 1 Cytochrome P450 CorC_HlyC PF03471.12 ERZ99910.1 - 0.0033 17.1 0.0 0.33 10.7 0.0 2.1 1 1 1 2 2 2 2 Transporter associated domain DUF3939 PF13075.1 ERZ99910.1 - 0.012 15.3 0.1 0.013 15.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) p450 PF00067.17 ERZ99911.1 - 1.8e-40 138.8 0.0 2e-40 138.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ERZ99911.1 - 0.037 13.9 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) p450 PF00067.17 ERZ99913.1 - 2.3e-71 240.7 0.0 3.2e-71 240.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ERZ99913.1 - 0.061 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) SAPS PF04499.10 ERZ99914.1 - 0.25 9.9 4.7 5.5 5.4 3.3 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein AAA_35 PF14516.1 ERZ99916.1 - 7.4e-10 37.9 0.1 4.9e-09 35.2 0.1 1.9 1 1 0 1 1 1 1 AAA-like domain AAA_14 PF13173.1 ERZ99916.1 - 8.2e-05 22.5 0.2 0.00035 20.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ERZ99916.1 - 0.00011 22.3 0.0 0.00022 21.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 ERZ99916.1 - 0.0021 17.7 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 ERZ99916.1 - 0.055 13.4 0.0 0.38 10.7 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 ERZ99916.1 - 0.086 12.9 0.0 0.23 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF3550 PF12070.3 ERZ99918.1 - 4.4e-143 477.7 0.2 5.7e-143 477.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3550/UPF0682) Yip1 PF04893.12 ERZ99919.1 - 1.1e-12 47.8 11.8 1.5e-12 47.3 8.2 1.2 1 0 0 1 1 1 1 Yip1 domain Aminotran_1_2 PF00155.16 ERZ99920.1 - 8.4e-45 153.2 0.0 9.5e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 ERZ99920.1 - 3.4e-07 28.8 0.0 5.4e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.15 ERZ99920.1 - 6.8e-06 24.8 0.1 2.6e-05 22.9 0.1 1.9 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Aminotran_5 PF00266.14 ERZ99920.1 - 0.00079 18.2 0.0 0.0013 17.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ERZ99920.1 - 0.0051 15.8 0.0 0.0079 15.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family CDP-OH_P_transf PF01066.16 ERZ99922.1 - 1.4e-16 60.5 6.4 2.7e-16 59.7 4.3 1.7 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase XLF PF09302.6 ERZ99923.1 - 2.5e-10 40.3 1.3 6.9e-10 38.9 0.9 1.7 1 1 0 1 1 1 1 XLF (XRCC4-like factor) NPHI_C PF08469.5 ERZ99923.1 - 0.053 13.4 0.1 0.18 11.7 0.0 1.9 1 1 1 2 2 2 0 Nucleoside triphosphatase I C-terminal Costars PF14705.1 ERZ99923.1 - 0.067 13.1 0.2 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Costars TPR_1 PF00515.23 ERZ99924.1 - 8.1e-56 183.4 34.7 1.5e-07 30.7 0.0 10.8 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ99924.1 - 1.8e-48 158.5 28.7 1.1e-05 24.9 0.0 10.3 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ99924.1 - 3.9e-48 160.9 43.0 1.8e-13 49.9 1.6 6.4 2 2 5 8 8 8 8 TPR repeat TPR_8 PF13181.1 ERZ99924.1 - 3.9e-34 113.8 25.5 4.5e-05 22.9 1.9 10.5 8 2 2 10 10 10 7 Tetratricopeptide repeat TPR_12 PF13424.1 ERZ99924.1 - 1.3e-31 108.3 27.7 5.3e-06 26.2 0.1 6.6 4 1 3 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ99924.1 - 4e-29 100.6 19.1 6.3e-08 33.0 0.0 6.3 3 2 4 7 7 7 7 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ99924.1 - 9.4e-28 94.1 13.0 0.00021 21.6 0.0 9.3 4 3 6 10 10 10 6 Tetratricopeptide repeat TPR_17 PF13431.1 ERZ99924.1 - 5e-25 85.5 27.7 0.0013 18.7 0.1 10.1 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ99924.1 - 1.8e-24 85.8 17.3 4.2e-06 27.0 0.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.1 ERZ99924.1 - 4.2e-24 82.3 18.9 0.0036 16.9 0.2 9.5 8 1 1 9 9 9 6 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ99924.1 - 4.7e-19 67.4 27.5 0.0026 18.0 0.0 10.1 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_9 PF13371.1 ERZ99924.1 - 1.5e-15 56.8 10.3 0.00077 19.2 0.1 5.7 4 2 2 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 ERZ99924.1 - 5.1e-11 42.5 17.7 1.3e-06 28.4 1.6 4.9 4 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 ERZ99924.1 - 1.2e-07 31.1 13.0 0.0087 15.1 1.9 4.3 1 1 1 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.1 ERZ99924.1 - 0.0054 15.9 20.7 0.21 10.7 1.5 4.8 2 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP DUF2225 PF09986.4 ERZ99924.1 - 0.0065 15.9 5.7 0.47 9.8 0.1 3.1 1 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_21 PF09976.4 ERZ99924.1 - 0.0088 15.9 19.5 0.38 10.6 2.7 4.5 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ99924.1 - 0.025 14.5 20.8 0.62 10.0 0.0 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_20 PF14561.1 ERZ99924.1 - 0.044 13.8 2.6 0.61 10.2 0.0 3.9 4 1 1 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ERZ99924.1 - 9.8 6.1 18.3 3.6 7.5 0.0 5.1 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Arm PF00514.18 ERZ99925.1 - 2.3e-07 30.4 3.2 0.92 9.4 0.0 6.7 8 0 0 8 8 8 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ERZ99925.1 - 1e-06 28.9 0.1 0.074 13.3 0.0 3.4 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 ERZ99925.1 - 0.021 15.2 0.5 12 6.4 0.0 4.2 3 1 1 4 4 4 0 HEAT-like repeat HEAT PF02985.17 ERZ99925.1 - 0.032 14.3 0.0 0.63 10.2 0.0 3.0 2 0 0 2 2 2 0 HEAT repeat HTH_24 PF13412.1 ERZ99926.1 - 0.038 13.3 0.8 0.12 11.7 0.0 2.1 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding Coatomer_E PF04733.9 ERZ99927.1 - 0.015 14.4 2.0 0.018 14.2 1.4 1.2 1 0 0 1 1 1 0 Coatomer epsilon subunit DUF948 PF06103.6 ERZ99927.1 - 0.047 13.5 0.5 0.067 13.0 0.3 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) MRP-S32 PF10210.4 ERZ99927.1 - 0.054 13.8 1.5 0.077 13.3 1.1 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 IncA PF04156.9 ERZ99927.1 - 1.5 8.3 11.5 1.6 8.2 8.0 1.2 1 0 0 1 1 1 0 IncA protein Uds1 PF15456.1 ERZ99927.1 - 2.2 8.2 11.0 0.63 10.0 5.6 1.6 1 1 1 2 2 2 0 Up-regulated During Septation V_ATPase_I PF01496.14 ERZ99927.1 - 2.4 5.9 7.8 2.6 5.8 5.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ERZ99927.1 - 4.1 6.3 13.2 4.5 6.2 9.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Pox_A_type_inc PF04508.7 ERZ99927.1 - 4.8 7.2 7.1 9.9 6.2 0.1 3.3 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat RibD_C PF01872.12 ERZ99928.1 - 5.9e-42 143.5 0.0 7.1e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain WD40 PF00400.27 ERZ99929.1 - 1e-27 94.9 6.8 1e-07 31.5 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat tRNA_bind PF01588.15 ERZ99930.1 - 0.067 13.0 0.1 0.096 12.5 0.1 1.3 1 0 0 1 1 1 0 Putative tRNA binding domain SAM_1 PF00536.25 ERZ99931.1 - 0.0087 16.2 0.0 0.022 14.9 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ribosomal_S19 PF00203.16 ERZ99932.1 - 0.055 13.0 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S19 Sel1 PF08238.7 ERZ99934.1 - 4.9e-23 81.0 5.3 1e-08 35.4 1.5 4.0 4 0 0 4 4 4 4 Sel1 repeat HMG_box PF00505.14 ERZ99937.1 - 0.00064 19.9 0.4 0.0018 18.5 0.0 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box Pkinase_Tyr PF07714.12 ERZ99937.1 - 0.015 14.4 0.0 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase HAUS4 PF14735.1 ERZ99937.1 - 0.072 12.3 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 Elongin_A PF06881.6 ERZ99937.1 - 0.1 12.9 1.7 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A HMG_box_2 PF09011.5 ERZ99937.1 - 0.11 12.9 0.1 0.67 10.3 0.0 2.2 2 1 0 2 2 2 0 HMG-box domain Fic_N PF13784.1 ERZ99937.1 - 0.14 11.9 0.1 0.6 10.0 0.0 1.9 2 0 0 2 2 2 0 Fic/DOC family N-terminal Dimer_Tnp_hAT PF05699.9 ERZ99938.1 - 1.8e-13 49.8 0.0 3.1e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region BTB PF00651.26 ERZ99939.1 - 1.7e-18 66.6 0.3 3.3e-18 65.6 0.1 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ERZ99939.1 - 0.00024 20.8 2.4 0.0024 17.6 0.4 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ERZ99940.1 - 2e-08 34.2 0.6 4.9e-08 33.0 0.1 1.7 2 0 0 2 2 2 1 TLD MerE PF05052.7 ERZ99941.1 - 0.087 12.8 0.4 0.092 12.7 0.3 1.2 1 0 0 1 1 1 0 MerE protein Pkinase_Tyr PF07714.12 ERZ99942.1 - 7.5e-28 97.2 0.0 2.5e-23 82.4 0.0 4.0 4 0 0 4 4 4 2 Protein tyrosine kinase Pkinase PF00069.20 ERZ99942.1 - 2e-17 63.2 1.5 2e-17 63.2 1.1 3.0 4 0 0 4 4 4 1 Protein kinase domain DZR PF12773.2 ERZ99942.1 - 2.3e-05 24.0 21.4 0.72 9.7 0.7 4.3 4 0 0 4 4 4 4 Double zinc ribbon DUF4447 PF14590.1 ERZ99942.1 - 0.0004 19.9 6.3 2 8.0 0.1 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF4447) Spt5-NGN PF03439.8 ERZ99942.1 - 0.0014 18.3 6.3 18 5.1 0.0 6.3 7 0 0 7 7 7 0 Early transcription elongation factor of RNA pol II, NGN section BCS1_N PF08740.6 ERZ99942.1 - 0.002 17.7 0.2 0.011 15.3 0.0 2.2 2 0 0 2 2 2 1 BCS1 N terminal S6PP_C PF08472.5 ERZ99942.1 - 0.0064 16.1 2.0 6.3 6.4 0.1 3.7 3 0 0 3 3 3 1 Sucrose-6-phosphate phosphohydrolase C-terminal HypA PF01155.14 ERZ99942.1 - 0.0069 16.0 15.4 2.9 7.6 0.2 4.6 4 0 0 4 4 4 2 Hydrogenase expression/synthesis hypA family PTH2 PF01981.11 ERZ99942.1 - 0.012 15.3 0.6 14 5.4 0.0 4.1 4 0 0 4 4 4 0 Peptidyl-tRNA hydrolase PTH2 NMD3 PF04981.8 ERZ99942.1 - 0.11 11.5 12.2 2.8 6.9 0.1 4.4 4 0 0 4 4 4 0 NMD3 family BCNT PF07572.7 ERZ99942.1 - 0.19 11.6 6.5 33 4.5 0.1 3.8 3 0 0 3 3 3 0 Bucentaur or craniofacial development NOB1_Zn_bind PF08772.6 ERZ99942.1 - 0.22 11.3 16.6 3.7 7.4 0.4 4.7 4 0 0 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like APH PF01636.18 ERZ99942.1 - 0.43 10.2 0.2 0.64 9.7 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zinc_ribbon_2 PF13240.1 ERZ99942.1 - 0.51 9.8 17.1 14 5.3 0.2 4.6 4 0 0 4 4 4 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 ERZ99942.1 - 0.55 10.6 12.1 7.9 6.9 0.2 4.4 4 0 0 4 4 4 0 Zinc-finger double domain C1_1 PF00130.17 ERZ99942.1 - 1.7 8.4 29.1 3.1 7.6 1.9 4.6 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BAG PF02179.11 ERZ99944.1 - 1.6e-06 28.0 0.8 2.2e-06 27.6 0.6 1.2 1 0 0 1 1 1 1 BAG domain BAG PF02179.11 ERZ99945.1 - 1.6e-06 28.0 0.4 2.7e-06 27.3 0.3 1.4 1 0 0 1 1 1 1 BAG domain HMG_box PF00505.14 ERZ99946.1 - 0.072 13.3 0.2 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box MKT1_N PF12247.3 ERZ99946.1 - 0.39 11.0 3.6 0.24 11.7 0.5 2.2 2 1 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication p450 PF00067.17 ERZ99947.1 - 3e-82 276.6 0.1 3.7e-82 276.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ERZ99948.1 - 2.2e-84 283.6 0.0 2.7e-84 283.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_6 PF12697.2 ERZ99949.1 - 2.3e-28 99.6 0.0 3.9e-28 98.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ERZ99949.1 - 2.2e-16 60.1 0.0 9.2e-16 58.0 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ERZ99949.1 - 1.2e-12 47.8 0.0 3.8e-12 46.1 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ERZ99949.1 - 0.0051 16.6 0.1 0.01 15.6 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase FSH1 PF03959.8 ERZ99949.1 - 0.045 13.1 0.0 14 5.0 0.0 2.7 2 1 0 3 3 3 0 Serine hydrolase (FSH1) ADK PF00406.17 ERZ99950.1 - 5.1e-49 166.0 0.0 7e-49 165.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 ERZ99950.1 - 3.2e-13 49.0 0.0 5.7e-13 48.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.1 ERZ99950.1 - 2.7e-06 27.6 0.0 6.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ERZ99950.1 - 0.0001 21.4 0.0 0.00029 20.0 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 ERZ99950.1 - 0.00067 20.4 0.0 0.0012 19.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ERZ99950.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain p450 PF00067.17 ERZ99951.1 - 2.2e-61 207.8 0.7 2.6e-61 207.5 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Myb_DNA-bind_4 PF13837.1 ERZ99953.1 - 4e-05 23.6 0.5 6.2e-05 23.0 0.4 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ERZ99953.1 - 0.0007 19.4 0.3 0.0013 18.6 0.2 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Pkinase_Tyr PF07714.12 ERZ99954.1 - 6e-38 130.3 0.0 7.3e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ERZ99954.1 - 2.8e-34 118.4 0.1 5.7e-34 117.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ERZ99954.1 - 0.0016 18.1 0.1 0.0026 17.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-UBR PF02207.15 ERZ99954.1 - 0.0077 15.9 1.0 0.015 14.9 0.7 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Methyltransf_12 PF08242.7 ERZ99954.1 - 0.029 14.8 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain EcKinase PF02958.15 ERZ99954.1 - 0.035 13.2 1.9 0.086 11.9 0.5 2.2 2 1 1 3 3 3 0 Ecdysteroid kinase Lactamase_B PF00753.22 ERZ99954.1 - 0.037 13.6 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Pkinase PF00069.20 ERZ99955.1 - 1.3e-09 37.5 0.2 1.5e-09 37.3 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99955.1 - 1.3e-07 30.9 0.3 1.5e-07 30.7 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ERZ99956.1 - 2.5e-45 151.9 5.9 9.4e-10 38.8 0.1 5.4 6 0 0 6 6 6 5 Sel1 repeat TPR_17 PF13431.1 ERZ99956.1 - 8.3e-05 22.4 0.7 1.5 9.1 0.0 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ERZ99956.1 - 0.00016 21.8 4.3 2.5 8.7 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat Exo_endo_phos_2 PF14529.1 ERZ99956.1 - 0.093 12.3 0.1 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase PPR PF01535.15 ERZ99956.1 - 0.34 10.9 6.6 9.1 6.5 0.0 4.8 5 0 0 5 5 5 0 PPR repeat TPR_11 PF13414.1 ERZ99956.1 - 0.38 10.4 10.5 0.25 10.9 2.0 3.5 1 1 2 3 3 3 0 TPR repeat Viral_cys_rich PF08008.7 ERZ99956.1 - 0.5 9.9 0.1 0.5 9.9 0.0 3.6 3 1 2 5 5 5 0 Viral cysteine rich MIT PF04212.13 ERZ99956.1 - 9.3 6.2 10.7 5.2 7.0 1.1 4.3 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain CNH PF00780.17 ERZ99959.1 - 4.8e-78 262.3 0.3 1.2e-77 261.0 0.1 1.7 2 0 0 2 2 2 1 CNH domain RhoGEF PF00621.15 ERZ99959.1 - 3.4e-40 137.8 0.7 5.9e-40 137.0 0.5 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.1 ERZ99959.1 - 9.5e-40 135.6 0.0 5.1e-39 133.3 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain DEP PF00610.16 ERZ99959.1 - 2.1e-13 49.8 0.3 5.6e-13 48.4 0.0 1.9 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CNH PF00780.17 ERZ99960.1 - 2.2e-62 211.0 0.0 3.3e-62 210.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.15 ERZ99960.1 - 3.1e-37 128.1 3.7 3.1e-37 128.1 2.5 2.4 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.1 ERZ99960.1 - 6.2e-18 65.0 0.0 6.2e-18 65.0 0.0 2.8 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.24 ERZ99960.1 - 1.3e-06 28.4 0.3 1.3e-05 25.3 0.0 2.9 3 0 0 3 3 3 1 PH domain DEP PF00610.16 ERZ99960.1 - 0.012 15.2 0.1 0.041 13.6 0.0 2.0 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SAGA-Tad1 PF12767.2 ERZ99961.1 - 2.7e-49 168.1 0.1 2.7e-49 168.1 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.9 ERZ99961.1 - 0.0049 16.1 0.0 0.0049 16.1 0.0 2.0 3 0 0 3 3 3 1 Transcription initiation factor TFIID component TAF4 family zf-DHHC PF01529.15 ERZ99962.1 - 7.9e-38 129.5 9.7 7.9e-38 129.5 6.7 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase CBP4 PF07960.6 ERZ99962.1 - 0.051 13.1 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 CBP4 rve_3 PF13683.1 ERZ99962.1 - 0.06 12.8 0.0 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain Inhibitor_I9 PF05922.11 ERZ99963.1 - 2.6e-07 31.0 0.1 4e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 FixP_N PF14715.1 ERZ99963.1 - 0.08 12.3 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Peptidase_A2E PF12382.3 ERZ99963.1 - 0.13 12.1 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Retrotransposon peptidase MIP-T3 PF10243.4 ERZ99964.1 - 0.072 11.5 16.9 0.084 11.3 11.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 PARP PF00644.15 ERZ99965.1 - 1.9e-10 40.5 0.0 2.5e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF4428 PF14471.1 ERZ99966.1 - 0.049 13.3 0.1 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) zf-CHCC PF10276.4 ERZ99966.1 - 0.065 13.0 0.3 0.089 12.6 0.2 1.3 1 0 0 1 1 1 0 Zinc-finger domain AAA_3 PF07726.6 ERZ99967.1 - 0.074 12.6 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.20 ERZ99968.1 - 1.8e-70 237.0 0.0 2.2e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ERZ99968.1 - 3.9e-31 108.0 0.0 5.6e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ERZ99968.1 - 0.0028 16.7 0.0 0.0049 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ERZ99968.1 - 0.015 15.0 1.1 0.07 12.8 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ERZ99968.1 - 0.08 11.8 0.0 0.21 10.5 0.0 1.6 1 1 1 2 2 2 0 Kinase-like tRNA-synt_1 PF00133.17 ERZ99969.1 - 3.4e-58 197.0 1.5 3.3e-20 71.6 2.0 6.7 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 ERZ99969.1 - 8.8e-43 145.7 0.5 5.5e-27 94.2 0.0 2.6 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 ERZ99969.1 - 2e-30 105.7 0.3 1e-21 77.0 0.1 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 ERZ99969.1 - 1.4e-12 47.6 0.0 3.7e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.14 ERZ99969.1 - 0.00022 20.1 0.0 0.00098 18.0 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (R) TPR_12 PF13424.1 ERZ99970.1 - 7.4e-19 67.4 8.4 5.7e-10 38.9 0.0 4.4 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 ERZ99970.1 - 1.6e-12 46.8 7.4 5.2e-09 35.6 0.1 4.1 4 1 0 4 4 4 2 TPR repeat TPR_7 PF13176.1 ERZ99970.1 - 2.5e-12 45.5 3.8 0.0015 18.1 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 ERZ99970.1 - 9.4e-12 44.0 13.1 0.001 18.5 0.0 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 ERZ99970.1 - 1.6e-11 43.1 8.3 0.0034 17.1 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 ERZ99970.1 - 1.1e-07 31.0 12.5 0.014 15.1 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 ERZ99970.1 - 1.4e-05 25.2 0.1 3 8.7 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 ERZ99970.1 - 7.3e-05 22.5 4.1 0.098 12.6 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ERZ99970.1 - 0.00011 22.7 0.2 5.3 7.8 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 ERZ99970.1 - 0.0009 19.0 0.3 0.17 11.7 0.0 3.3 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ERZ99970.1 - 0.0063 16.6 1.9 14 6.2 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 ERZ99970.1 - 0.0063 16.8 2.2 1.3 9.4 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.4 ERZ99970.1 - 0.0081 15.5 0.3 2.6 7.3 0.1 3.2 2 2 2 4 4 4 1 26S proteasome subunit RPN7 TPR_6 PF13174.1 ERZ99970.1 - 0.015 15.7 0.9 46 4.7 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ERZ99970.1 - 0.078 13.1 5.1 2.3 8.3 1.5 3.5 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.4 ERZ99970.1 - 0.089 12.2 3.1 1.6 8.1 1.4 2.9 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) RhoGEF PF00621.15 ERZ99971.1 - 1.5e-51 174.7 0.4 1.5e-51 174.7 0.3 2.3 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.16 ERZ99971.1 - 9.7e-26 89.4 21.3 1.8e-19 69.3 6.8 2.6 2 0 0 2 2 2 2 FYVE zinc finger PH PF00169.24 ERZ99971.1 - 2.7e-08 33.9 0.4 2.7e-08 33.9 0.3 3.0 3 0 0 3 3 3 1 PH domain FYVE_2 PF02318.11 ERZ99971.1 - 7.8e-06 25.7 17.5 0.0011 18.7 2.9 2.7 2 0 0 2 2 2 2 FYVE-type zinc finger PH_11 PF15413.1 ERZ99971.1 - 0.008 16.4 0.8 0.038 14.2 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain HypA PF01155.14 ERZ99971.1 - 0.44 10.2 12.0 0.28 10.8 1.7 3.0 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family IBR PF01485.16 ERZ99971.1 - 1.1 9.2 15.3 4.2 7.3 2.7 2.7 2 0 0 2 2 2 0 IBR domain DUF1840 PF08895.6 ERZ99972.1 - 0.00043 20.2 0.8 0.00064 19.6 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1840) TFIIF_alpha PF05793.7 ERZ99972.1 - 0.015 13.6 7.4 0.016 13.5 5.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Calc_CGRP_IAPP PF00214.14 ERZ99972.1 - 0.024 14.6 0.6 0.032 14.2 0.4 1.3 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family EndoU_bacteria PF14436.1 ERZ99972.1 - 0.027 14.2 0.5 0.032 14.0 0.3 1.2 1 0 0 1 1 1 0 Bacterial EndoU nuclease DUF3484 PF11983.3 ERZ99972.1 - 0.037 14.8 2.0 0.066 14.0 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) DUF1676 PF07898.8 ERZ99972.1 - 0.18 12.1 1.5 0.24 11.6 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) FAM178 PF14816.1 ERZ99972.1 - 0.19 10.4 3.6 0.24 10.0 2.5 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 FKBP_N PF01346.13 ERZ99972.1 - 0.26 11.3 5.5 0.4 10.7 3.8 1.2 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Cobl PF09469.5 ERZ99972.1 - 1.1 9.2 4.7 2.1 8.3 3.2 1.6 1 1 0 1 1 1 0 Cordon-bleu ubiquitin-like domain Vpu PF00558.14 ERZ99972.1 - 1.1 8.8 5.0 1.9 8.0 2.9 1.8 2 0 0 2 2 2 0 Vpu protein Sfi1_C PF10638.4 ERZ99973.1 - 0.0056 17.0 0.1 0.0093 16.3 0.0 1.3 1 0 0 1 1 1 1 Spindle body associated protein C-terminus Cnl2_NKP2 PF09447.5 ERZ99973.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Cnl2/NKP2 family protein DDE_1 PF03184.14 ERZ99975.1 - 2.4e-09 36.6 0.2 2.5e-09 36.5 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease BTB PF00651.26 ERZ99976.1 - 1.4e-11 44.3 0.0 3.1e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ERZ99976.1 - 7.7e-11 42.1 1.7 7.7e-11 42.1 1.2 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ERZ99976.1 - 1.5e-07 31.1 1.1 1.6e-06 27.8 0.1 3.1 2 1 0 2 2 2 1 BTB And C-terminal Kelch STAT2_C PF12188.3 ERZ99976.1 - 0.022 14.5 0.2 0.058 13.1 0.1 1.7 1 0 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal Ribosomal_S13 PF00416.17 ERZ99979.1 - 1.9e-29 102.2 0.2 2.1e-29 102.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 ERZ99979.1 - 0.00039 19.0 0.0 0.00044 18.9 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) IMS_HHH PF11798.3 ERZ99979.1 - 0.15 12.1 0.1 0.5 10.5 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif Exo_endo_phos_2 PF14529.1 ERZ99980.1 - 7.1e-10 38.5 1.2 1.5e-09 37.5 0.8 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ99980.1 - 6.2e-09 36.1 0.0 9.1e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LptE PF04390.7 ERZ99980.1 - 0.12 12.1 0.4 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide-assembly Exo_endo_phos_2 PF14529.1 ERZ99981.1 - 1e-08 34.8 2.9 1e-08 34.7 0.6 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ERZ99981.1 - 7e-07 29.4 0.0 1.2e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2252 PF10009.4 ERZ99981.1 - 0.17 10.7 1.0 0.33 9.8 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) VPR PF00522.13 ERZ99981.1 - 1.6 8.5 5.3 5.5 6.8 0.1 3.2 3 0 0 3 3 3 0 VPR/VPX protein MIR PF02815.14 ERZ99982.1 - 0.0058 16.1 0.0 0.014 14.9 0.0 1.7 1 1 0 1 1 1 1 MIR domain Ins145_P3_rec PF08709.6 ERZ99982.1 - 0.05 12.6 0.0 0.075 12.0 0.0 1.4 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor SRP54 PF00448.17 ERZ99983.1 - 0.00066 19.1 0.0 0.00066 19.1 0.0 1.0 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AIG1 PF04548.11 ERZ99984.1 - 1.9e-34 118.6 0.1 3.2e-34 117.8 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Hint PF01079.15 ERZ99984.1 - 2e-32 112.1 0.0 5.6e-32 110.6 0.0 1.6 2 0 0 2 2 2 1 Hint module MMR_HSR1 PF01926.18 ERZ99984.1 - 4e-13 49.3 0.1 8e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ99984.1 - 3.7e-07 30.0 1.8 0.002 18.0 0.1 2.9 2 1 1 3 3 3 2 Dynamin family SRPRB PF09439.5 ERZ99984.1 - 2.8e-06 26.6 1.3 3.6e-06 26.3 0.1 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ERZ99984.1 - 4.2e-06 26.0 0.0 7.6e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ERZ99984.1 - 7.6e-05 22.0 0.1 0.00017 20.9 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.1 ERZ99984.1 - 0.00014 22.1 0.1 0.0004 20.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 ERZ99984.1 - 0.00028 21.3 0.0 0.00055 20.4 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Septin PF00735.13 ERZ99984.1 - 0.0004 19.5 0.0 0.00067 18.7 0.0 1.3 1 0 0 1 1 1 1 Septin Gtr1_RagA PF04670.7 ERZ99984.1 - 0.00068 18.8 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.1 ERZ99984.1 - 0.0014 18.6 0.0 0.015 15.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 ERZ99984.1 - 0.0016 18.7 0.2 0.0064 16.7 0.0 2.0 2 1 0 2 2 2 1 ABC transporter DUF87 PF01935.12 ERZ99984.1 - 0.0016 18.2 0.1 0.078 12.7 0.4 2.3 1 1 1 2 2 2 1 Domain of unknown function DUF87 AAA_17 PF13207.1 ERZ99984.1 - 0.0019 18.9 0.5 0.011 16.5 0.3 2.5 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ERZ99984.1 - 0.0023 17.4 0.1 0.003 17.0 0.1 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 ERZ99984.1 - 0.0026 17.9 0.1 0.01 15.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ERZ99984.1 - 0.0049 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ERZ99984.1 - 0.0051 16.2 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain PduV-EutP PF10662.4 ERZ99984.1 - 0.0054 16.2 0.2 0.012 15.0 0.1 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 ERZ99984.1 - 0.0067 16.0 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ERZ99984.1 - 0.0092 14.9 0.1 0.017 14.0 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ERZ99984.1 - 0.015 14.7 0.0 0.036 13.5 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family GTP_EFTU PF00009.22 ERZ99984.1 - 0.016 14.6 0.4 0.17 11.3 0.3 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.17 ERZ99984.1 - 0.021 13.6 0.0 0.69 8.7 0.0 2.2 1 1 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 ERZ99984.1 - 0.048 13.8 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.7 ERZ99984.1 - 0.069 12.2 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 ERZ99984.1 - 0.11 12.1 0.4 0.38 10.3 0.2 2.0 1 1 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.21 ERZ99984.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.7 ERZ99984.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Sigma54_activ_2 PF14532.1 ERZ99984.1 - 0.14 12.2 0.0 1.5 8.8 0.0 2.6 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_23 PF13476.1 ERZ99984.1 - 2.9 8.1 5.8 0.52 10.6 0.1 2.2 2 1 0 2 2 2 0 AAA domain AIG1 PF04548.11 ERZ99985.1 - 8.9e-18 64.1 0.1 2.1e-17 62.9 0.1 1.6 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ERZ99985.1 - 2.8e-11 43.3 0.0 3.5e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ERZ99985.1 - 1.9e-08 34.3 0.1 0.00077 19.3 0.1 2.2 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.11 ERZ99985.1 - 3.1e-07 29.7 0.0 5.2e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ERZ99985.1 - 3.1e-05 23.3 0.1 5.1e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.22 ERZ99985.1 - 0.00012 22.4 0.5 0.00015 22.0 0.3 1.4 1 1 0 1 1 1 1 ABC transporter AAA_17 PF13207.1 ERZ99985.1 - 0.00022 21.9 0.3 0.0022 18.8 0.2 2.1 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ERZ99985.1 - 0.0016 17.7 0.0 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ERZ99985.1 - 0.002 18.1 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.7 ERZ99985.1 - 0.0021 17.2 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.1 ERZ99985.1 - 0.0023 18.2 0.4 0.0059 16.9 0.3 1.7 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 ERZ99985.1 - 0.0034 16.4 0.0 0.0059 15.6 0.0 1.5 1 1 0 1 1 1 1 KAP family P-loop domain Miro PF08477.8 ERZ99985.1 - 0.0042 17.5 0.0 0.0065 16.9 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein AAA_29 PF13555.1 ERZ99985.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Septin PF00735.13 ERZ99985.1 - 0.0076 15.2 0.1 0.018 14.0 0.0 1.6 2 0 0 2 2 2 1 Septin AAA_33 PF13671.1 ERZ99985.1 - 0.011 15.6 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ERZ99985.1 - 0.017 14.8 0.1 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain GTP_EFTU PF00009.22 ERZ99985.1 - 0.017 14.5 0.2 0.37 10.2 0.1 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 ERZ99985.1 - 0.02 14.3 0.4 0.058 12.8 0.2 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 ERZ99985.1 - 0.022 14.8 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ERZ99985.1 - 0.035 13.5 0.1 0.057 12.8 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain ATP_bind_1 PF03029.12 ERZ99985.1 - 0.045 13.2 1.4 3.8 6.9 0.0 2.5 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.7 ERZ99985.1 - 0.052 12.6 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin T2SE PF00437.15 ERZ99985.1 - 0.054 12.3 0.4 0.19 10.6 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein NB-ARC PF00931.17 ERZ99985.1 - 0.076 11.8 0.0 0.33 9.7 0.0 1.8 1 1 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 ERZ99985.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Sec1 PF00995.18 ERZ99986.1 - 1.2e-93 314.7 0.8 1.4e-93 314.4 0.5 1.1 1 0 0 1 1 1 1 Sec1 family FAR1 PF03101.10 ERZ99988.1 - 4.1e-06 27.2 0.1 5.3e-06 26.8 0.1 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.6 ERZ99988.1 - 0.021 15.0 0.0 0.024 14.8 0.0 1.2 1 0 0 1 1 1 0 Transcription factor AFT RNase_H PF00075.19 ERZ99989.1 - 1.5e-05 25.3 0.2 4.1e-05 23.9 0.2 1.7 2 1 0 2 2 2 1 RNase H zf-BED PF02892.10 ERZ99990.1 - 0.00019 21.0 5.4 0.00041 20.0 3.7 1.6 1 0 0 1 1 1 1 BED zinc finger RVT_1 PF00078.22 ERZ99994.1 - 0.00061 19.1 1.1 0.0028 17.0 0.3 1.9 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TctC PF03401.9 ERZ99997.1 - 0.08 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor HTH_Tnp_Tc5 PF03221.11 ERZ99999.1 - 5.4e-15 54.9 0.0 9.3e-15 54.2 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain PA14 PF07691.7 ERZ99999.1 - 0.0092 15.6 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 PA14 domain DNA_gyraseB PF00204.20 ESA00002.1 - 2.4e-31 108.2 0.1 5.6e-31 107.0 0.1 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 ESA00002.1 - 2.8e-10 39.9 0.0 4.8e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESA00002.1 - 5.4e-07 29.3 0.4 5.4e-07 29.3 0.3 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NusA_N PF08529.6 ESA00002.1 - 0.12 12.3 3.5 0.97 9.4 0.0 3.3 4 0 0 4 4 4 0 NusA N-terminal domain ORC6 PF05460.8 ESA00002.1 - 0.46 9.5 14.7 0.81 8.7 10.2 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) MIF4G PF02854.14 ESA00003.1 - 2.7e-24 85.7 4.6 3.4e-24 85.4 3.2 1.1 1 0 0 1 1 1 1 MIF4G domain MIF4G PF02854.14 ESA00004.1 - 1e-20 74.0 2.2 1e-20 74.0 1.5 1.6 2 0 0 2 2 2 1 MIF4G domain DUF1776 PF08643.5 ESA00004.1 - 0.0083 15.2 0.3 0.72 8.9 0.0 2.1 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) Peptidase_M22 PF00814.20 ESA00005.1 - 8.5e-25 87.7 0.0 9.7e-25 87.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family CmcH_NodU PF02543.10 ESA00005.1 - 0.025 13.7 0.1 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Carbamoyltransferase NARP1 PF12569.3 ESA00006.1 - 0.28 9.9 4.8 0.38 9.4 3.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 V_ATPase_I PF01496.14 ESA00006.1 - 2.3 5.9 3.9 3.1 5.5 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DEAD PF00270.24 ESA00008.1 - 1.6e-21 76.5 0.7 1.7e-20 73.2 0.2 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA00008.1 - 2.4e-09 36.9 0.0 7.9e-09 35.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain P3A PF08727.6 ESA00008.1 - 0.0065 15.7 1.5 0.028 13.7 0.1 2.6 2 0 0 2 2 2 1 Poliovirus 3A protein like CMS1 PF14617.1 ESA00008.1 - 0.016 14.2 0.4 0.038 13.0 0.0 1.8 2 1 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 ESA00008.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Helicase C-terminal domain DUF221 PF02714.10 ESA00009.1 - 5.7e-88 294.8 25.2 5.7e-88 294.8 17.5 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ESA00009.1 - 2.4e-40 137.6 1.0 2.4e-40 137.6 0.7 2.9 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ESA00009.1 - 2.8e-12 46.9 0.0 5.4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) zf-CCHC PF00098.18 ESA00010.1 - 0.041 13.8 19.5 0.06 13.2 1.4 3.4 2 1 1 3 3 3 0 Zinc knuckle DUF2721 PF11026.3 ESA00010.1 - 1.9 8.1 3.7 11 5.6 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) BTB PF00651.26 ESA00011.1 - 1.3e-16 60.5 0.1 2.3e-16 59.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Med2 PF11214.3 ESA00012.1 - 0.0014 18.6 5.3 0.0014 18.6 3.7 2.5 3 0 0 3 3 3 1 Mediator complex subunit 2 SPOUT_MTase PF02590.12 ESA00012.1 - 9.6 5.9 7.4 11 5.6 1.2 2.4 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase Med28 PF11594.3 ESA00014.1 - 0.01 16.0 3.1 0.022 15.0 2.1 1.6 1 0 0 1 1 1 0 Mediator complex subunit 28 G2F PF07474.7 ESA00014.1 - 0.041 13.2 0.2 0.058 12.7 0.2 1.2 1 0 0 1 1 1 0 G2F domain ATG16 PF08614.6 ESA00014.1 - 0.042 13.6 6.5 0.099 12.4 2.4 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3835 PF12927.2 ESA00014.1 - 0.055 14.4 1.0 0.2 12.6 0.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) TAFH PF07531.9 ESA00014.1 - 0.084 12.5 1.6 0.16 11.5 0.2 2.0 2 1 0 2 2 2 0 NHR1 homology to TAF PCI_Csn8 PF10075.4 ESA00014.1 - 0.2 11.4 5.3 2 8.1 0.1 2.4 1 1 1 2 2 2 0 COP9 signalosome, subunit CSN8 Maelstrom PF13017.1 ESA00014.1 - 1.1 8.6 5.8 1.1 8.7 2.9 1.9 1 1 0 1 1 1 0 piRNA pathway germ-plasm component Fib_alpha PF08702.5 ESA00014.1 - 1.4 9.0 7.5 1.3 9.1 4.2 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Cu-oxidase PF00394.17 ESA00015.1 - 5.1e-39 133.7 1.6 1.4e-38 132.3 0.0 2.4 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 ESA00015.1 - 7.4e-36 122.4 0.8 1.7e-34 118.0 0.1 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA00015.1 - 2e-28 98.5 4.6 5.7e-28 97.1 0.2 2.8 3 0 0 3 3 3 1 Multicopper oxidase SIR2 PF02146.12 ESA00018.1 - 3.1e-30 105.2 0.0 4.6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 ESA00018.1 - 0.0034 17.1 0.1 0.11 12.2 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain SCP2 PF02036.12 ESA00018.1 - 0.089 13.0 0.0 1.3 9.3 0.0 2.5 1 1 0 2 2 2 0 SCP-2 sterol transfer family DDE_1 PF03184.14 ESA00019.1 - 5.6e-58 195.6 0.8 1.9e-35 122.0 0.0 2.4 2 0 0 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA00019.1 - 0.00013 21.6 0.5 0.00048 19.8 0.1 2.2 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Hydrolase_3 PF08282.7 ESA00019.1 - 1.4 8.4 6.9 0.26 10.8 0.6 2.4 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Nucleoplasmin PF03066.10 ESA00019.1 - 1.4 8.3 16.2 0.29 10.6 0.2 3.2 3 0 0 3 3 3 0 Nucleoplasmin Prothymosin PF03247.9 ESA00020.1 - 6.4 6.9 21.5 1.3 9.2 7.2 2.8 2 0 0 2 2 2 0 Prothymosin/parathymosin family PCI PF01399.22 ESA00021.1 - 1.6e-20 73.4 0.4 9.4e-20 70.8 0.0 2.3 2 0 0 2 2 2 1 PCI domain TPR_14 PF13428.1 ESA00021.1 - 0.067 13.8 0.1 9.2 7.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat UreD PF01774.12 ESA00022.1 - 2.6e-48 164.2 0.0 3e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein dsrm PF00035.20 ESA00023.1 - 0.00058 20.3 0.0 0.00099 19.6 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ESA00023.1 - 0.0033 17.6 0.3 0.023 14.9 0.2 2.0 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Flp_Fap PF04964.9 ESA00024.1 - 0.083 12.5 2.9 0.14 11.8 2.0 1.3 1 0 0 1 1 1 0 Flp/Fap pilin component Sec62 PF03839.11 ESA00024.1 - 0.092 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 GP41 PF00517.12 ESA00024.1 - 0.093 12.2 0.0 0.094 12.2 0.0 1.1 1 0 0 1 1 1 0 Retroviral envelope protein HTH_23 PF13384.1 ESA00025.1 - 0.00059 19.4 0.0 0.0014 18.1 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.7 ESA00025.1 - 0.011 15.1 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 TetR_N PF00440.18 ESA00025.1 - 0.019 14.5 0.1 0.042 13.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_28 PF13518.1 ESA00025.1 - 0.043 13.8 0.0 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_5 PF01022.15 ESA00025.1 - 0.052 13.2 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.1 ESA00025.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.5 ESA00025.1 - 0.062 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_38 PF13936.1 ESA00025.1 - 0.088 12.3 0.6 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain RNase_H PF00075.19 ESA00026.1 - 0.0043 17.4 0.0 0.0047 17.2 0.0 1.2 1 0 0 1 1 1 1 RNase H DUF2430 PF10353.4 ESA00026.1 - 0.081 13.1 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) SieB PF14163.1 ESA00027.1 - 0.048 13.2 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Superinfection exclusion protein B EphA2_TM PF14575.1 ESA00027.1 - 0.2 12.0 1.5 0.88 10.0 0.1 2.8 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Prim_Zn_Ribbon PF08273.7 ESA00028.1 - 0.23 11.5 8.2 0.11 12.5 3.4 2.1 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Arch_flagellin PF01917.11 ESA00029.1 - 0.00037 20.1 0.2 0.00045 19.8 0.1 1.3 1 1 0 1 1 1 1 Archaebacterial flagellin TH1 PF04858.8 ESA00030.1 - 1.1e-21 76.6 0.6 1.2e-21 76.5 0.4 1.0 1 0 0 1 1 1 1 TH1 protein UPF0014 PF03649.8 ESA00031.1 - 7.9e-42 143.1 14.1 1.1e-41 142.6 9.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) FtsX PF02687.16 ESA00031.1 - 0.006 16.3 7.3 0.006 16.3 5.1 3.1 2 2 1 3 3 3 1 FtsX-like permease family PGG PF13962.1 ESA00031.1 - 0.092 12.3 0.1 0.092 12.3 0.1 2.8 2 1 2 4 4 4 0 Domain of unknown function CBS PF00571.23 ESA00032.1 - 4.6e-29 99.9 1.9 1e-07 31.5 0.0 4.4 4 0 0 4 4 4 4 CBS domain MULE PF10551.4 ESA00032.1 - 0.081 13.1 0.0 0.3 11.2 0.0 2.0 1 0 0 1 1 1 0 MULE transposase domain BiPBP_C PF06832.7 ESA00032.1 - 0.14 12.0 0.1 0.78 9.7 0.0 2.2 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family PLDc PF00614.17 ESA00032.1 - 9.4 6.1 7.8 25 4.8 0.0 3.4 3 0 0 3 3 3 0 Phospholipase D Active site motif DUF1640 PF07798.6 ESA00033.1 - 2.4e-22 79.8 2.3 3.4e-22 79.3 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Cellulase PF00150.13 ESA00035.1 - 1e-20 74.0 0.3 9.1e-15 54.5 0.0 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Smr PF01713.16 ESA00036.1 - 1.7e-10 40.9 0.0 3.9e-10 39.7 0.0 1.6 2 0 0 2 2 2 1 Smr domain DUF1877 PF08974.5 ESA00041.1 - 0.057 13.0 0.1 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1877) Sel1 PF08238.7 ESA00043.1 - 8e-199 639.7 106.5 2.5e-10 40.6 0.2 24.1 24 0 0 24 24 24 23 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00043.1 - 8.8e-39 133.1 0.0 2e-37 128.6 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00043.1 - 2e-31 109.1 1.1 2e-31 109.1 0.7 1.8 2 0 0 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA00043.1 - 7.4e-14 51.1 70.6 0.21 12.1 0.1 18.6 21 0 0 21 21 21 7 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA00043.1 - 5.4e-05 23.1 1.0 0.63 10.0 0.0 5.5 5 1 1 6 6 6 1 Influenza Matrix protein (M1) C-terminal domain Trigger_C PF05698.9 ESA00043.1 - 0.0012 18.7 2.2 0.0033 17.3 0.1 3.0 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus RQC PF09382.5 ESA00043.1 - 0.056 13.1 11.9 0.15 11.7 0.2 5.4 4 2 0 4 4 4 0 RQC domain Rep-A_N PF04057.7 ESA00043.1 - 0.065 13.0 0.1 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain B12-binding_2 PF02607.12 ESA00043.1 - 0.22 11.5 1.7 2e+02 2.1 0.0 5.5 6 0 0 6 6 6 0 B12 binding domain Siva PF05458.7 ESA00043.1 - 5.1 6.6 5.0 51 3.3 0.1 3.5 4 0 0 4 4 4 0 Cd27 binding protein (Siva) Peptidase_S8 PF00082.17 ESA00045.1 - 8.2e-47 159.6 8.1 1.1e-46 159.3 5.6 1.1 1 0 0 1 1 1 1 Subtilase family PTE PF02126.13 ESA00045.1 - 0.015 14.3 0.1 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotriesterase family GHMP_kinases_N PF00288.21 ESA00045.1 - 0.039 14.0 0.1 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 GHMP kinases N terminal domain HATPase_c_3 PF13589.1 ESA00045.1 - 3.2 7.4 8.5 0.21 11.2 0.3 2.9 2 1 1 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glyoxalase PF00903.20 ESA00046.1 - 3.6e-12 46.3 0.2 6.7e-12 45.4 0.1 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 ESA00046.1 - 1.2e-09 38.7 0.0 1.6e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 ESA00046.1 - 0.011 15.7 0.0 0.041 13.9 0.0 1.9 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF3683 PF12447.3 ESA00047.1 - 0.053 13.3 0.1 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3683) Sel1 PF08238.7 ESA00050.1 - 2.1e-23 82.2 12.3 3.7e-06 27.3 0.7 5.3 5 1 1 6 6 6 4 Sel1 repeat TPR_11 PF13414.1 ESA00050.1 - 0.8 9.3 6.7 1.5 8.5 0.1 3.0 2 1 2 4 4 4 0 TPR repeat Pkinase_Tyr PF07714.12 ESA00051.1 - 3.1e-08 33.0 0.0 3.5e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00051.1 - 0.0002 20.6 0.0 0.00024 20.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Exo_endo_phos_2 PF14529.1 ESA00053.1 - 8.7e-09 35.0 1.8 8.7e-09 35.0 1.3 3.8 4 0 0 4 4 4 1 Endonuclease-reverse transcriptase RVT_1 PF00078.22 ESA00053.1 - 1.8e-06 27.4 0.1 5.7e-06 25.8 0.1 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.18 ESA00053.1 - 0.00028 20.9 0.0 0.00059 19.8 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family APG6 PF04111.7 ESA00054.1 - 1.2e-117 392.4 10.0 1.7e-117 392.0 6.9 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 BH3 PF15285.1 ESA00054.1 - 1.8e-05 24.1 0.0 6.7e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 Beclin-1 BH3 domain, Bcl-2-interacting V_ATPase_I PF01496.14 ESA00054.1 - 0.011 13.6 3.8 0.014 13.2 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.1 ESA00054.1 - 0.039 13.1 16.5 0.015 14.4 9.2 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF607 PF04678.8 ESA00054.1 - 0.11 12.4 1.2 0.22 11.4 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Filament PF00038.16 ESA00054.1 - 0.22 10.9 17.8 0.014 14.8 7.1 2.4 2 1 1 3 3 3 0 Intermediate filament protein DMPK_coil PF08826.5 ESA00054.1 - 0.45 10.4 10.9 1.1 9.1 7.5 1.7 1 0 0 1 1 1 0 DMPK coiled coil domain like IncA PF04156.9 ESA00054.1 - 2.6 7.5 19.6 4.2 6.9 13.1 1.7 1 1 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 ESA00054.1 - 5.5 6.9 11.6 11 5.9 8.0 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein ClpS PF02617.12 ESA00056.1 - 0.018 14.7 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS PsbU PF06514.6 ESA00056.1 - 0.13 12.1 0.7 0.28 11.0 0.5 1.7 1 1 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) BTB PF00651.26 ESA00057.1 - 1.5e-11 44.2 1.3 2.5e-11 43.5 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA00057.1 - 7.4e-10 38.9 0.0 1.5e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA00057.1 - 0.00024 20.8 2.3 0.0013 18.4 0.8 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Cu-oxidase_3 PF07732.10 ESA00058.1 - 0.0099 15.6 0.4 0.013 15.2 0.3 1.2 1 0 0 1 1 1 1 Multicopper oxidase Cu_bind_like PF02298.12 ESA00058.1 - 0.03 14.1 0.2 0.044 13.5 0.1 1.4 1 0 0 1 1 1 0 Plastocyanin-like domain SoxE PF06525.6 ESA00058.1 - 1.5 8.0 6.5 0.2 10.9 0.9 1.9 1 1 1 2 2 2 0 Sulfocyanin (SoxE) RNA_pol_Rpb1_1 PF04997.7 ESA00059.1 - 1e-121 406.3 5.4 1.2e-121 406.1 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 ESA00059.1 - 6.7e-109 363.4 0.6 1.1e-108 362.6 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 ESA00059.1 - 8.6e-68 227.4 0.0 8.6e-68 227.4 0.0 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 ESA00059.1 - 5.9e-63 211.9 8.6 1.3e-62 210.8 5.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 ESA00059.1 - 1.2e-52 177.7 0.0 3e-52 176.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 ESA00059.1 - 7.5e-41 139.0 2.4 7.5e-41 139.0 1.6 2.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 ESA00059.1 - 1.7e-37 127.4 0.5 1.7e-37 127.4 0.3 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 ESA00059.1 - 0.056 13.5 260.8 0.05 13.7 8.5 16.1 11 3 7 18 18 18 0 RNA polymerase Rpb1 C-terminal repeat Spore-coat_CotD PF11122.3 ESA00061.1 - 0.33 11.2 8.9 0.11 12.8 4.1 1.7 2 0 0 2 2 2 0 Inner spore coat protein D YTH PF04146.10 ESA00062.1 - 5e-51 171.9 0.2 6.2e-51 171.6 0.1 1.1 1 0 0 1 1 1 1 YT521-B-like domain PLD_C PF12357.3 ESA00062.1 - 0.11 12.0 0.0 1 8.9 0.0 2.2 2 0 0 2 2 2 0 Phospholipase D C terminal N6_Mtase PF02384.11 ESA00063.1 - 0.046 12.8 1.0 0.048 12.7 0.7 1.0 1 0 0 1 1 1 0 N-6 DNA Methylase Gemin7 PF11095.3 ESA00063.1 - 0.12 12.1 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) zf-CCCH PF00642.19 ESA00064.1 - 9.1e-10 37.9 2.4 1.6e-09 37.2 1.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.1 ESA00064.1 - 5.5e-09 35.9 10.7 1e-08 35.0 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA00064.1 - 1.8e-08 33.9 5.3 3e-08 33.2 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA00064.1 - 2.2e-07 30.5 7.8 3.6e-07 29.9 5.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESA00064.1 - 1.3e-06 28.0 10.1 2.2e-06 27.2 7.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA00064.1 - 8.5e-06 25.3 10.7 1.8e-05 24.2 7.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA00064.1 - 5.3e-05 22.8 4.7 0.00015 21.3 3.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA00064.1 - 5.8e-05 22.8 9.0 0.00015 21.5 6.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 ESA00064.1 - 0.00091 18.6 3.5 0.00091 18.6 2.4 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RanBP PF00641.13 ESA00064.1 - 0.0013 17.8 4.4 0.0032 16.5 3.1 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-P11 PF03854.9 ESA00064.1 - 0.013 14.9 3.5 0.028 13.9 2.4 1.5 1 0 0 1 1 1 0 P-11 zinc finger Prok-RING_4 PF14447.1 ESA00064.1 - 0.12 11.9 3.7 0.25 10.9 2.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.2 ESA00064.1 - 0.16 12.1 5.1 0.52 10.4 3.5 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger DEAD PF00270.24 ESA00065.1 - 2.5e-44 150.7 0.1 5.3e-42 143.1 0.0 2.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA00065.1 - 6.3e-27 93.2 0.2 1.7e-26 91.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEM4 PF02602.10 ESA00065.1 - 0.0034 16.6 0.1 0.0059 15.8 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD FoP_duplication PF13865.1 ESA00066.1 - 3.2 8.2 9.3 5.5 7.5 6.5 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF2956 PF11169.3 ESA00066.1 - 4.9 7.1 6.7 7.6 6.5 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) HCO3_cotransp PF00955.16 ESA00067.1 - 0.072 11.7 0.0 0.085 11.4 0.0 1.0 1 0 0 1 1 1 0 HCO3- transporter family DUF4061 PF13270.1 ESA00069.1 - 0.0046 17.0 0.1 0.0054 16.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) Sel1 PF08238.7 ESA00072.1 - 4.5e-07 30.2 0.0 6.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA00072.1 - 0.0025 17.5 0.5 0.0032 17.2 0.3 1.2 1 0 0 1 1 1 1 zinc-ribbons zf-C2H2_jaz PF12171.3 ESA00072.1 - 0.05 13.7 1.6 0.053 13.6 0.2 1.8 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding PHF5 PF03660.9 ESA00072.1 - 0.1 12.6 0.3 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 PHF5-like protein zf-BED PF02892.10 ESA00072.1 - 0.31 10.8 4.5 9 6.1 3.1 2.3 1 1 0 1 1 1 0 BED zinc finger Toxin_25 PF08095.6 ESA00072.1 - 0.41 10.4 0.2 0.41 10.4 0.1 2.4 2 0 0 2 2 2 0 Hefutoxin family DUF2256 PF10013.4 ESA00072.1 - 0.58 9.9 4.6 0.25 11.1 1.3 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) AAA PF00004.24 ESA00073.1 - 6e-14 52.3 0.0 1.5e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA00073.1 - 6.7e-08 32.7 0.0 1.7e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA00073.1 - 1e-06 28.8 0.0 2.1e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 ESA00073.1 - 2.4e-05 24.0 0.1 0.00012 21.7 0.1 2.1 1 1 0 1 1 1 1 NACHT domain PIF1 PF05970.9 ESA00073.1 - 8.1e-05 21.7 0.0 0.00017 20.6 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.1 ESA00073.1 - 0.00019 21.0 0.0 0.00043 19.9 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 ESA00073.1 - 0.0015 18.2 1.4 0.0041 16.8 0.9 1.8 1 1 0 1 1 1 1 Archaeal ATPase NTPase_1 PF03266.10 ESA00073.1 - 0.0017 18.1 0.2 0.004 16.8 0.2 1.7 1 0 0 1 1 1 1 NTPase Zot PF05707.7 ESA00073.1 - 0.0023 17.4 0.0 0.0049 16.3 0.0 1.6 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_11 PF13086.1 ESA00073.1 - 0.0027 17.2 0.4 0.0069 15.9 0.0 1.8 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.8 ESA00073.1 - 0.0033 16.2 0.0 0.017 13.8 0.0 1.9 2 0 0 2 2 2 1 TIP49 C-terminus Miro PF08477.8 ESA00073.1 - 0.0039 17.6 0.0 0.01 16.3 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Cdc6_C PF09079.6 ESA00073.1 - 0.0046 16.6 0.0 0.024 14.3 0.0 2.3 2 0 0 2 2 2 1 CDC6, C terminal AAA_17 PF13207.1 ESA00073.1 - 0.0053 17.5 0.0 0.014 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA00073.1 - 0.0082 15.2 0.0 0.017 14.1 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin ResIII PF04851.10 ESA00073.1 - 0.015 15.1 0.5 0.06 13.1 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.4 ESA00073.1 - 0.018 14.0 0.0 0.032 13.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 ESA00073.1 - 0.018 13.8 0.0 0.035 12.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.1 ESA00073.1 - 0.019 14.8 0.0 0.052 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 ESA00073.1 - 0.029 14.1 0.1 1 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.8 ESA00073.1 - 0.031 13.2 0.0 0.077 11.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) KAP_NTPase PF07693.9 ESA00073.1 - 0.033 13.1 0.5 2.9 6.8 0.0 2.2 1 1 0 2 2 2 0 KAP family P-loop domain AAA_32 PF13654.1 ESA00073.1 - 0.038 12.6 0.0 0.077 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA12 PF10443.4 ESA00073.1 - 0.041 12.3 0.1 4.3 5.7 0.0 2.3 2 0 0 2 2 2 0 RNA12 protein RNA_helicase PF00910.17 ESA00073.1 - 0.043 13.9 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 1 0 RNA helicase T2SE PF00437.15 ESA00073.1 - 0.048 12.5 0.2 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.1 ESA00073.1 - 0.048 13.9 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Bromodomain PF00439.20 ESA00074.1 - 8.3e-18 64.0 0.2 8.8e-18 64.0 0.1 1.0 1 0 0 1 1 1 1 Bromodomain Methyltransf_PK PF05891.7 ESA00075.1 - 1.4e-84 282.7 0.1 1.7e-84 282.4 0.1 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_18 PF12847.2 ESA00075.1 - 7.9e-10 39.3 0.0 1.2e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA00075.1 - 6.7e-09 36.1 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA00075.1 - 1.3e-08 34.7 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA00075.1 - 4.5e-08 33.3 0.0 7.3e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA00075.1 - 6.8e-08 32.8 0.0 1.1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA00075.1 - 8.6e-06 25.4 0.2 1.3e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pox_vIL-18BP PF05566.7 ESA00075.1 - 0.0024 17.8 0.1 0.004 17.1 0.1 1.5 1 0 0 1 1 1 1 Orthopoxvirus interleukin 18 binding protein Methyltransf_2 PF00891.13 ESA00075.1 - 0.0091 15.2 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase RrnaAD PF00398.15 ESA00075.1 - 0.027 13.4 0.0 0.045 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CheR PF01739.13 ESA00075.1 - 0.069 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain KbaA PF14089.1 ESA00076.1 - 0.0058 16.1 8.1 0.0058 16.1 5.6 1.9 1 1 1 2 2 2 2 KinB-signalling pathway activation in sporulation DUF2569 PF10754.4 ESA00076.1 - 0.008 16.4 12.3 0.017 15.3 8.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2569) Stimulus_sens_1 PF13756.1 ESA00076.1 - 0.17 12.2 0.1 0.27 11.6 0.1 1.2 1 0 0 1 1 1 0 Stimulus-sensing domain Dimer_Tnp_hAT PF05699.9 ESA00077.1 - 0.001 18.6 0.1 0.023 14.2 0.0 2.3 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region HtrL_YibB PF09612.5 ESA00077.1 - 0.0061 15.8 0.9 0.0061 15.8 0.6 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (HtrL_YibB) FG-GAP PF01839.18 ESA00078.1 - 1.3e-23 82.0 12.8 4.2e-06 26.2 0.1 5.0 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.1 ESA00078.1 - 1.6e-12 47.6 15.2 5.1e-05 23.5 2.4 5.0 3 1 3 6 6 6 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Zn_dep_PLPC PF00882.13 ESA00078.1 - 9.5e-09 35.1 2.1 1.7e-08 34.2 0.4 2.1 2 0 0 2 2 2 1 Zinc dependent phospholipase C TcdB_toxin_midN PF12256.3 ESA00078.1 - 2e-06 27.3 1.4 2.7 7.4 0.0 4.3 3 1 1 4 4 4 3 Insecticide toxin TcdB middle/N-terminal region TSP_3 PF02412.13 ESA00078.1 - 0.5 9.8 7.0 5.6 6.5 0.5 3.5 3 0 0 3 3 3 0 Thrombospondin type 3 repeat CLPTM1 PF05602.7 ESA00079.1 - 4.6e-149 496.8 12.2 5.8e-149 496.5 8.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF912 PF06024.7 ESA00079.1 - 0.0051 16.8 0.7 0.087 12.8 0.1 2.9 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1183 PF06682.7 ESA00079.1 - 0.15 11.6 0.8 1.7 8.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) DUF1673 PF07895.6 ESA00079.1 - 4.6 6.6 14.1 1.2 8.6 6.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1673) Sel1 PF08238.7 ESA00081.1 - 4.3e-09 36.7 1.0 0.0068 17.0 0.6 3.7 4 0 0 4 4 4 2 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00081.1 - 0.0024 17.0 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4188 PF13826.1 ESA00081.1 - 0.069 13.2 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) Fip1 PF05182.8 ESA00082.1 - 2.4e-26 90.7 3.7 5.4e-26 89.5 2.5 1.7 1 0 0 1 1 1 1 Fip1 motif AJAP1_PANP_C PF15298.1 ESA00082.1 - 0.082 12.7 0.5 0.082 12.7 0.4 2.0 2 0 0 2 2 2 0 AJAP1/PANP C-terminus BACK PF07707.10 ESA00083.1 - 4.9e-06 26.3 5.2 0.00037 20.2 0.4 3.1 2 1 1 3 3 3 3 BTB And C-terminal Kelch NESP55 PF06390.7 ESA00084.1 - 7.9 5.7 9.3 8.5 5.6 6.5 1.0 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) zf-CCHC PF00098.18 ESA00085.1 - 0.0069 16.2 4.8 0.01 15.7 3.4 1.3 1 0 0 1 1 1 1 Zinc knuckle Utp13 PF08625.6 ESA00085.1 - 0.21 11.2 2.1 1.1 8.8 0.0 2.4 2 1 1 3 3 3 0 Utp13 specific WD40 associated domain TPR_11 PF13414.1 ESA00086.1 - 3.6e-12 45.7 1.2 3.6e-12 45.7 0.8 3.4 3 1 1 4 4 4 1 TPR repeat SET PF00856.23 ESA00086.1 - 6.8e-09 36.2 0.1 4.5e-08 33.5 0.1 2.3 1 1 0 1 1 1 1 SET domain TPR_1 PF00515.23 ESA00086.1 - 3.3e-07 29.6 10.6 0.002 17.6 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00086.1 - 5.4e-07 29.0 5.6 0.022 14.6 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00086.1 - 6.5e-06 25.9 5.0 0.034 14.3 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00086.1 - 1e-05 25.7 2.6 0.94 9.8 0.1 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA00086.1 - 0.00078 19.5 4.4 0.011 15.8 2.7 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESA00086.1 - 0.00099 19.7 0.0 0.006 17.2 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00086.1 - 0.024 15.2 0.0 0.66 10.7 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00086.1 - 0.036 14.0 4.9 0.2 11.6 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00086.1 - 1.9 8.4 6.3 5.9 6.9 0.3 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA00088.1 - 3.5e-43 147.5 0.0 1.1e-42 145.8 0.0 1.7 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00088.1 - 1.7e-39 135.5 0.8 7.3e-39 133.4 0.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Lipoprotein_X PF03305.8 ESA00089.1 - 0.05 12.9 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein Pkinase_Tyr PF07714.12 ESA00090.1 - 3.3e-47 160.7 0.0 1.2e-41 142.5 0.0 4.7 4 1 0 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ESA00090.1 - 4.6e-39 134.1 0.1 4.6e-39 134.1 0.0 4.8 7 1 1 8 8 8 2 Protein kinase domain BCS1_N PF08740.6 ESA00090.1 - 0.00085 18.9 2.6 0.51 9.9 0.0 5.5 7 0 0 7 7 7 1 BCS1 N terminal RNA_bind_2 PF10133.4 ESA00090.1 - 0.02 14.9 1.9 5.6 7.0 0.1 4.0 3 0 0 3 3 3 0 Predicted RNA-binding protein APH PF01636.18 ESA00090.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Arrestin_N PF00339.24 ESA00092.1 - 8.3e-07 28.9 0.1 1.1e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Vps26 PF03643.10 ESA00092.1 - 0.0034 16.2 0.0 0.0034 16.2 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Sipho_tail PF05709.6 ESA00092.1 - 0.1 11.7 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Phage tail protein BCDHK_Adom3 PF10436.4 ESA00093.1 - 3.6e-67 224.9 0.0 5.1e-67 224.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESA00093.1 - 6.8e-19 67.6 0.0 2e-18 66.0 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESA00093.1 - 0.0001 21.9 0.0 0.00017 21.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BC10 PF06726.7 ESA00094.1 - 2.7e-15 56.1 8.8 5.4e-15 55.1 6.1 1.5 2 0 0 2 2 2 1 Bladder cancer-related protein BC10 RRM_1 PF00076.17 ESA00095.1 - 1.6e-39 133.3 5.6 3.4e-21 74.6 0.1 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA00095.1 - 6.3e-32 109.3 4.0 3.3e-14 52.5 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA00095.1 - 5.3e-20 71.0 5.9 1.2e-08 34.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 ESA00095.1 - 6.4e-16 57.7 3.1 3.1e-09 36.3 0.2 3.4 3 0 0 3 3 3 3 Poly-adenylate binding protein, unique domain Limkain-b1 PF11608.3 ESA00095.1 - 1.6e-06 27.7 0.9 0.88 9.3 0.0 3.8 3 0 0 3 3 3 3 Limkain b1 RRM_3 PF08777.6 ESA00095.1 - 0.0094 15.7 0.4 0.5 10.2 0.0 3.4 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM PF05172.8 ESA00095.1 - 0.03 14.0 0.5 0.34 10.6 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif WHIM3 PF15614.1 ESA00095.1 - 0.072 12.8 0.1 0.31 10.8 0.0 2.1 2 0 0 2 2 2 0 WSTF, HB1, Itc1p, MBD9 motif 3 Pkinase_Tyr PF07714.12 ESA00099.1 - 4.6e-46 157.0 0.0 5.8e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00099.1 - 2.7e-42 144.7 0.2 4.7e-42 143.9 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain ABC2_membrane PF01061.19 ESA00101.1 - 2.1 7.4 9.9 0.22 10.6 4.0 1.5 2 0 0 2 2 2 0 ABC-2 type transporter Helitron_like_N PF14214.1 ESA00102.1 - 0.026 14.2 0.1 0.03 14.0 0.1 1.1 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus DUF1443 PF07280.6 ESA00102.1 - 0.47 10.0 3.0 1.3 8.6 2.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1443) p450 PF00067.17 ESA00103.1 - 3.5e-07 29.1 0.6 6.1e-06 25.0 0.1 2.0 1 1 1 2 2 2 2 Cytochrome P450 STAG PF08514.6 ESA00104.1 - 2.7e-06 27.0 0.2 1.3e-05 24.8 0.1 2.2 1 0 0 1 1 1 1 STAG domain AT_hook PF02178.14 ESA00104.1 - 0.0045 16.5 71.6 0.028 14.0 1.4 7.0 7 0 0 7 7 7 5 AT hook motif RFX5_DNA_bdg PF14621.1 ESA00104.1 - 0.02 14.4 1.5 0.02 14.4 1.0 6.5 1 1 5 6 6 6 0 RFX5 DNA-binding domain Pex2_Pex12 PF04757.9 ESA00105.1 - 3.6e-47 160.7 16.0 4.3e-47 160.4 11.1 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 ESA00105.1 - 5.1e-08 32.8 2.3 9.8e-08 31.8 1.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA00105.1 - 2.1e-05 24.2 5.6 4e-05 23.4 3.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESA00105.1 - 3e-05 23.6 1.7 5.8e-05 22.6 1.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA00105.1 - 0.00012 21.8 1.8 0.00012 21.8 1.2 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA00105.1 - 0.00014 21.4 0.4 0.00025 20.6 0.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Med15_fungi PF05397.7 ESA00105.1 - 0.1 12.6 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Mediator complex subunit 15 WD40 PF00400.27 ESA00106.1 - 7e-13 47.9 10.1 2.7e-07 30.1 0.1 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Cellulase-like PF12876.2 ESA00106.1 - 0.011 16.2 0.0 0.41 11.1 0.0 2.7 2 1 0 2 2 2 0 Sugar-binding cellulase-like Apc4_WD40 PF12894.2 ESA00106.1 - 0.11 12.0 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.20 ESA00107.1 - 3.3e-32 111.6 0.2 3.9e-32 111.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00107.1 - 7.7e-18 64.4 0.0 9.4e-18 64.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA00107.1 - 0.14 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family CDC50 PF03381.10 ESA00108.1 - 0.041 13.0 0.6 0.051 12.7 0.4 1.1 1 0 0 1 1 1 0 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF4481 PF14800.1 ESA00110.1 - 0.0012 17.8 0.0 0.0018 17.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) Pox_A51 PF04948.8 ESA00110.1 - 0.09 11.4 1.3 0.12 10.9 0.9 1.1 1 0 0 1 1 1 0 Poxvirus A51 protein KH_1 PF00013.24 ESA00112.1 - 4.4e-09 35.8 2.3 8.9e-09 34.8 1.6 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ESA00112.1 - 9.5e-07 28.3 2.1 2.2e-06 27.1 1.5 1.6 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ESA00112.1 - 0.021 14.3 1.0 0.061 12.8 0.7 1.8 1 0 0 1 1 1 0 KH domain KH_4 PF13083.1 ESA00112.1 - 0.023 14.3 2.9 0.073 12.7 0.2 2.5 1 1 1 2 2 2 0 KH domain DUF1660 PF07874.6 ESA00112.1 - 0.031 14.5 0.1 0.087 13.1 0.0 1.8 2 0 0 2 2 2 0 Prophage protein (DUF1660) DUF1237 PF06824.6 ESA00113.1 - 2.8e-33 115.1 1.8 3.4e-33 114.8 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) HSP70 PF00012.15 ESA00114.1 - 1.5e-198 660.5 6.2 1.8e-198 660.3 4.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA00114.1 - 1.4e-12 46.8 0.1 4e-12 45.3 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA00114.1 - 0.016 14.2 0.0 0.064 12.3 0.0 2.0 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Myb_DNA-bind_6 PF13921.1 ESA00115.1 - 0.0092 16.0 2.6 0.076 13.1 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain RNA_pol_Rpb2_45 PF10385.4 ESA00115.1 - 0.09 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain DUF3994 PF13159.1 ESA00115.1 - 0.094 12.9 0.7 0.14 12.4 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) CCG PF02754.11 ESA00118.1 - 0.018 15.0 0.1 4.8 7.2 0.0 2.2 2 0 0 2 2 2 0 Cysteine-rich domain DUF4568 PF15132.1 ESA00118.1 - 0.052 12.7 0.5 5.8 6.0 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4568) DUF2650 PF10853.3 ESA00118.1 - 0.51 9.8 5.9 2.5 7.6 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) PcF PF09461.5 ESA00118.1 - 0.73 9.7 3.5 13 5.7 0.5 2.3 2 0 0 2 2 2 0 Phytotoxin PcF protein Pkinase PF00069.20 ESA00119.1 - 6.3e-06 25.5 0.2 2e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00119.1 - 0.00026 20.1 0.1 0.022 13.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase UDPG_MGDP_dh_C PF03720.10 ESA00119.1 - 0.028 14.5 0.1 0.082 13.0 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Pkinase_Tyr PF07714.12 ESA00122.1 - 3.1e-39 134.6 0.0 6.6e-38 130.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00122.1 - 2e-32 112.3 0.1 1.6e-31 109.3 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA00122.1 - 0.33 10.6 0.7 0.6 9.8 0.3 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Dynamin_N PF00350.18 ESA00123.1 - 1e-13 51.4 0.1 2.1e-13 50.4 0.0 1.5 2 0 0 2 2 2 1 Dynamin family OMP_b-brl_2 PF13568.1 ESA00124.1 - 0.016 14.9 0.2 0.029 14.1 0.1 1.4 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain MACPF PF01823.14 ESA00125.1 - 0.0005 19.8 5.3 0.0005 19.8 3.7 2.3 2 0 0 2 2 2 1 MAC/Perforin domain DUF573 PF04504.9 ESA00125.1 - 0.0017 18.5 6.9 0.028 14.6 0.1 3.8 4 0 0 4 4 4 2 Protein of unknown function, DUF573 HATPase_c_3 PF13589.1 ESA00128.1 - 0.018 14.7 0.1 0.11 12.1 0.1 2.0 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Metallophos PF00149.23 ESA00129.1 - 0.0005 19.5 0.2 0.0008 18.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA00129.1 - 0.0047 16.7 0.0 0.016 15.0 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain UCR_TM PF02921.9 ESA00129.1 - 0.035 14.3 0.2 0.079 13.2 0.0 1.6 2 0 0 2 2 2 0 Ubiquinol cytochrome reductase transmembrane region Metallophos PF00149.23 ESA00130.1 - 2.3e-12 46.7 6.7 1.4e-11 44.1 4.7 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA00130.1 - 8.4e-05 22.4 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 ESA00131.1 - 1.5e-12 47.3 8.2 6.1e-12 45.3 5.7 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA00131.1 - 1.9e-05 24.5 0.0 4e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CPSase_L_D2 PF02786.12 ESA00132.1 - 3.7e-74 248.5 0.0 6.9e-74 247.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESA00132.1 - 2.5e-39 133.7 0.1 1.9e-38 130.9 0.0 2.4 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESA00132.1 - 1.7e-35 121.2 0.0 4e-35 120.0 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 ESA00132.1 - 7.8e-16 57.4 0.2 4.1e-15 55.1 0.2 2.3 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 ESA00132.1 - 1.5e-11 44.4 0.0 2.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESA00132.1 - 5.4e-09 35.7 0.0 1.4e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 ESA00132.1 - 4.7e-08 32.1 0.0 1.3e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 ESA00132.1 - 3.7e-05 23.6 0.0 7.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESA00132.1 - 0.00015 21.3 0.0 0.1 12.2 0.0 2.8 1 1 1 2 2 2 2 Biotin-lipoyl like RimK PF08443.6 ESA00132.1 - 0.00059 19.3 0.2 0.0037 16.7 0.0 2.3 2 1 0 2 2 2 1 RimK-like ATP-grasp domain HlyD_3 PF13437.1 ESA00132.1 - 0.078 13.3 0.6 4.1 7.7 0.0 3.4 4 0 0 4 4 3 0 HlyD family secretion protein RnfC_N PF13375.1 ESA00132.1 - 0.084 12.5 0.1 1 9.1 0.0 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Sel1 PF08238.7 ESA00133.1 - 4.9e-57 189.1 22.0 4.6e-10 39.8 0.1 8.7 9 0 0 9 9 9 7 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00133.1 - 3.3e-51 173.8 0.0 5.2e-51 173.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00133.1 - 3.8e-49 167.1 0.4 6.3e-49 166.4 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA00133.1 - 0.00014 21.1 0.7 0.00049 19.3 0.5 1.9 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA00133.1 - 0.0041 16.8 0.0 0.0064 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family TPR_11 PF13414.1 ESA00133.1 - 0.019 14.6 9.6 0.032 13.8 1.7 4.0 2 1 2 4 4 4 0 TPR repeat Col_cuticle_N PF01484.12 ESA00133.1 - 0.051 13.2 0.4 0.15 11.7 0.3 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain TPR_17 PF13431.1 ESA00133.1 - 0.061 13.5 6.7 1 9.7 0.3 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA00133.1 - 0.21 11.4 5.6 11 5.9 0.0 4.2 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3092 PF11289.3 ESA00134.1 - 0.018 14.3 1.6 0.021 14.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3092) Chromosome_seg PF13889.1 ESA00134.1 - 0.11 12.4 0.1 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Chromosome segregation during meiosis DUF2304 PF10066.4 ESA00134.1 - 0.19 11.5 4.7 0.26 11.1 3.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Intg_mem_TP0381 PF09529.5 ESA00134.1 - 0.2 10.8 3.1 0.27 10.4 2.2 1.2 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) RmlD_sub_bind PF04321.12 ESA00135.1 - 2e-12 46.6 0.0 2.3e-12 46.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain NAP PF00956.13 ESA00135.1 - 0.012 14.7 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) LRR_6 PF13516.1 ESA00137.1 - 6e-14 50.5 0.9 1.7e-05 24.3 0.0 4.5 4 1 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 ESA00137.1 - 6.5e-10 38.4 1.0 3.4e-06 26.5 0.2 3.0 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA00137.1 - 9e-09 34.1 5.8 0.085 12.9 0.0 4.9 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_8 PF13855.1 ESA00137.1 - 4.3e-08 32.7 0.2 6.1e-06 25.9 0.0 3.0 2 1 0 2 2 2 1 Leucine rich repeat LRR_7 PF13504.1 ESA00137.1 - 6.4e-06 25.5 0.8 0.76 10.2 0.0 4.5 4 0 0 4 4 4 2 Leucine rich repeat G-7-MTase PF12803.2 ESA00137.1 - 0.018 14.2 0.1 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Adeno_E4_34 PF04528.8 ESA00137.1 - 0.48 10.0 7.4 0.99 8.9 1.0 2.3 1 1 1 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region DUF869 PF05911.6 ESA00138.1 - 0.028 12.6 2.4 0.024 12.9 1.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Flavodoxin_NdrI PF07972.6 ESA00138.1 - 0.089 12.7 1.4 0.2 11.5 0.9 1.6 1 0 0 1 1 1 0 NrdI Flavodoxin like Zein PF01559.11 ESA00138.1 - 0.11 11.7 0.1 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Zein seed storage protein HMG_box PF00505.14 ESA00139.1 - 6.6e-05 23.1 4.6 0.0035 17.5 3.2 2.5 1 1 0 1 1 1 1 HMG (high mobility group) box CPSase_L_D3 PF02787.14 ESA00139.1 - 0.072 12.8 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain HMG_box PF00505.14 ESA00140.1 - 0.00053 20.2 1.6 0.011 16.0 1.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box DUF2774 PF11242.3 ESA00140.1 - 0.015 15.2 0.2 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Gp37_Gp68 PF07505.6 ESA00140.1 - 0.036 13.2 0.1 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Phage protein Gp37/Gp68 Cation_ATPase_N PF00690.21 ESA00140.1 - 0.21 11.0 1.0 0.68 9.4 0.1 2.1 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus zf-C5HC2 PF02928.11 ESA00141.1 - 0.093 12.8 0.6 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 C5HC2 zinc finger Transcrip_reg PF01709.15 ESA00141.1 - 1.2 8.1 3.3 11 5.0 1.0 2.2 2 1 0 2 2 2 0 Transcriptional regulator HTH_29 PF13551.1 ESA00145.1 - 2.1e-07 31.0 0.0 2.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA00145.1 - 5.6e-07 29.0 0.0 1.1e-06 28.1 0.0 1.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 ESA00145.1 - 4.9e-06 26.4 0.1 8.4e-06 25.6 0.0 1.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.10 ESA00145.1 - 2.8e-05 23.8 0.3 0.00054 19.7 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_11 PF08279.7 ESA00145.1 - 0.0079 15.8 0.1 0.016 14.8 0.0 1.6 2 0 0 2 2 2 1 HTH domain HTH_38 PF13936.1 ESA00145.1 - 0.011 15.3 0.2 0.025 14.1 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.14 ESA00145.1 - 0.024 14.3 0.0 0.038 13.7 0.0 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_32 PF13565.1 ESA00145.1 - 0.029 15.1 0.2 0.12 13.2 0.1 1.8 1 1 1 2 2 2 0 Homeodomain-like domain Phage_AlpA PF05930.7 ESA00145.1 - 0.036 13.7 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) RRM_1 PF00076.17 ESA00146.1 - 6.5e-58 192.2 4.1 4.2e-17 61.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA00146.1 - 2.5e-42 142.6 0.9 1.9e-11 43.7 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA00146.1 - 2.8e-18 65.5 0.2 0.00017 21.3 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA00146.1 - 0.0063 16.2 0.0 1.9 8.3 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif LRR_4 PF12799.2 ESA00147.1 - 4.1e-08 32.6 1.4 5.2e-05 22.7 0.2 3.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA00147.1 - 1.7e-06 27.5 5.5 4.1e-05 23.2 0.0 3.7 4 0 0 4 4 4 1 Leucine Rich repeat LRR_8 PF13855.1 ESA00147.1 - 2.5e-05 23.9 4.2 0.0014 18.3 0.2 2.9 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESA00147.1 - 0.00014 21.4 8.8 0.059 13.4 0.1 4.7 5 1 1 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA00147.1 - 0.0011 18.7 2.5 0.51 10.7 0.0 4.2 5 0 0 5 5 5 1 Leucine rich repeat E2F_TDP PF02319.15 ESA00150.1 - 0.018 14.5 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Uricase PF01014.13 ESA00150.1 - 0.056 13.5 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Uricase LolB PF03550.9 ESA00150.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.4 1 1 0 1 1 1 0 Outer membrane lipoprotein LolB Kelch_4 PF13418.1 ESA00151.1 - 1.1e-11 44.2 0.3 0.033 13.9 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA00151.1 - 9.2e-09 35.0 0.0 0.069 13.1 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.1 ESA00151.1 - 2.4e-07 30.6 2.3 1.8 8.8 0.0 4.9 3 2 1 4 4 4 3 Kelch motif Kelch_3 PF13415.1 ESA00151.1 - 2.6e-07 30.6 1.0 0.013 15.6 0.0 4.9 4 2 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA00151.1 - 1.6e-06 27.6 0.2 0.095 12.5 0.0 4.7 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.20 ESA00151.1 - 1.9e-05 24.1 0.1 0.42 10.1 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Aldo_ket_red PF00248.16 ESA00152.1 - 1.1e-07 30.9 0.0 1.2e-07 30.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family BatD PF13584.1 ESA00153.1 - 1.3 7.5 4.3 1.3 7.5 3.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance DUF1049 PF06305.6 ESA00153.1 - 6.9 6.2 11.0 7.5e+02 -0.3 7.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1049) Ras PF00071.17 ESA00154.1 - 3.4e-60 202.1 0.1 4.1e-60 201.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA00154.1 - 2.5e-18 66.6 0.0 4.3e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA00154.1 - 4.6e-12 45.5 0.0 5.9e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA00154.1 - 0.00013 21.8 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESA00154.1 - 0.0013 17.9 0.0 0.0017 17.5 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA00154.1 - 0.0014 18.0 0.1 0.015 14.7 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.1 ESA00154.1 - 0.013 15.0 0.0 0.023 14.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA00154.1 - 0.017 15.2 0.0 0.097 12.8 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.1 ESA00154.1 - 0.07 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 ESA00154.1 - 0.11 11.4 0.0 0.25 10.2 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF2341 PF10102.4 ESA00154.1 - 0.13 12.4 1.0 13 6.0 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF2341) zf-CCHC PF00098.18 ESA00155.1 - 1.9e-08 33.8 2.6 3.7e-08 32.9 1.8 1.5 1 0 0 1 1 1 1 Zinc knuckle CTD_bind PF04818.8 ESA00155.1 - 2.8e-08 33.8 0.5 4.9e-08 33.0 0.4 1.4 1 0 0 1 1 1 1 RNA polymerase II-binding domain. G-patch PF01585.18 ESA00155.1 - 1.6e-07 31.0 2.2 3.7e-07 29.8 1.5 1.6 1 0 0 1 1 1 1 G-patch domain dUTPase PF00692.14 ESA00156.1 - 2.7e-35 120.6 0.0 3.9e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 dUTPase LCM PF04072.9 ESA00157.1 - 3.8e-24 85.2 0.0 5.2e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase OTU PF02338.14 ESA00158.1 - 1.2e-08 35.5 0.2 5.1e-08 33.5 0.0 2.2 2 0 0 2 2 2 1 OTU-like cysteine protease TipAS PF07739.8 ESA00158.1 - 0.073 13.3 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain GST_C PF00043.20 ESA00160.1 - 6.5e-08 32.4 0.1 2.1e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA00160.1 - 0.00016 21.4 0.2 0.0031 17.3 0.1 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA00160.1 - 0.0012 19.3 0.0 0.0017 18.8 0.0 1.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DDE_Tnp_1_7 PF13843.1 ESA00163.1 - 1.3e-27 96.8 0.0 8.7e-20 71.0 0.0 2.7 1 1 1 2 2 2 2 Transposase IS4 FoP_duplication PF13865.1 ESA00163.1 - 3.7 8.0 7.9 9 6.8 5.5 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Rad33 PF08730.5 ESA00164.1 - 0.0013 18.2 0.2 0.002 17.6 0.2 1.3 1 0 0 1 1 1 1 Rad33 DUF1664 PF07889.7 ESA00166.1 - 0.0064 16.2 0.5 0.01 15.6 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) DUF972 PF06156.8 ESA00166.1 - 0.052 13.9 0.2 0.085 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Fmp27_WPPW PF10359.4 ESA00166.1 - 0.054 11.9 0.3 0.06 11.7 0.2 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Syntaxin-18_N PF10496.4 ESA00166.1 - 0.083 12.7 0.3 0.72 9.7 0.1 2.2 1 1 1 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Peptidase_S8 PF00082.17 ESA00168.1 - 3.1e-45 154.5 0.4 5.1e-45 153.8 0.3 1.3 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 ESA00168.1 - 1.4e-08 35.0 0.0 3.7e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) PB1 PF00564.19 ESA00170.1 - 0.2 11.3 1.4 0.5 10.0 0.0 2.2 2 0 0 2 2 2 0 PB1 domain Wzz PF02706.10 ESA00170.1 - 0.97 9.2 4.5 1.5 8.6 0.0 2.3 2 1 0 2 2 2 0 Chain length determinant protein Sel1 PF08238.7 ESA00171.1 - 2e-26 91.8 8.0 2.2e-10 40.7 0.1 4.1 4 0 0 4 4 4 3 Sel1 repeat DUF3674 PF12426.3 ESA00171.1 - 0.00081 18.7 1.1 2.2 7.7 0.0 3.1 3 0 0 3 3 3 2 RNA dependent RNA polymerase zf-GRF PF06839.7 ESA00171.1 - 0.0014 18.5 3.3 0.8 9.6 0.1 2.3 2 0 0 2 2 2 2 GRF zinc finger HEPN PF05168.9 ESA00171.1 - 0.003 17.4 1.0 0.57 10.0 0.1 2.1 1 1 1 2 2 2 2 HEPN domain TPR_17 PF13431.1 ESA00171.1 - 0.0064 16.6 2.1 4 7.8 0.0 3.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00171.1 - 0.0097 16.3 0.8 3.1 8.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF282 PF03380.9 ESA00171.1 - 0.066 12.9 0.1 16 5.3 0.0 2.3 2 0 0 2 2 2 0 Caenorhabditis protein of unknown function, DUF282 TPR_11 PF13414.1 ESA00171.1 - 0.23 11.1 5.5 0.56 9.9 0.3 2.6 1 1 2 3 3 3 0 TPR repeat Apc3 PF12895.2 ESA00171.1 - 0.29 11.2 2.1 3 8.0 0.1 2.5 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA00171.1 - 2.8 8.0 8.8 86 3.4 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA00172.1 - 1.7e-57 190.5 27.1 6.6e-12 45.6 1.1 6.3 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA00172.1 - 3.3e-05 23.6 20.1 1.3 9.0 0.0 5.5 4 1 1 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA00172.1 - 4.9e-05 23.1 17.7 0.039 13.8 0.3 5.0 1 1 4 5 5 5 4 Tetratricopeptide repeat B2 PF11473.3 ESA00172.1 - 6.2e-05 22.5 0.3 0.66 9.6 0.0 3.3 2 1 1 3 3 3 2 RNA binding protein B2 Plasmid_stabil PF05016.9 ESA00172.1 - 0.00022 21.5 2.0 0.99 9.8 0.0 3.7 1 1 2 3 3 3 1 Plasmid stabilisation system protein Surfac_D-trimer PF09006.6 ESA00172.1 - 0.0013 18.3 6.7 24 4.7 0.0 5.1 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA00172.1 - 0.0042 17.1 16.8 15 6.1 0.0 6.8 6 4 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA00172.1 - 0.019 14.8 5.2 23 5.0 0.0 5.3 6 1 0 6 6 6 0 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA00172.1 - 0.08 12.9 0.2 25 4.9 0.0 3.6 1 1 3 4 4 4 0 Influenza Matrix protein (M1) C-terminal domain AnfG_VnfG PF03139.10 ESA00172.1 - 0.25 11.1 5.6 6.2 6.6 0.1 3.4 1 1 3 4 4 4 0 Vanadium/alternative nitrogenase delta subunit DUF4531 PF15041.1 ESA00172.1 - 0.56 9.9 4.8 4.8 6.8 0.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4531) Glu_syn_central PF04898.9 ESA00172.1 - 0.59 9.3 3.8 11 5.2 0.0 3.2 2 2 2 4 4 4 0 Glutamate synthase central domain Foie-gras_1 PF11817.3 ESA00172.1 - 1.1 8.6 9.0 6.2 6.2 2.8 2.6 1 1 1 2 2 2 0 Foie gras liver health family 1 DUF3830 PF12903.2 ESA00172.1 - 2.8 7.3 9.8 20 4.5 0.0 4.4 4 2 0 5 5 5 0 Protein of unknown function (DUF3830) TPR_6 PF13174.1 ESA00172.1 - 3 8.5 13.0 1.6 9.3 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat STE PF02200.11 ESA00172.1 - 4 7.6 15.2 18 5.5 0.1 4.8 2 2 1 4 4 4 0 STE like transcription factor Spatacsin_C PF14649.1 ESA00172.1 - 4.6 6.0 12.6 4.7 5.9 0.9 2.6 1 1 3 4 4 4 0 Spatacsin C-terminus DUF1100 PF06500.6 ESA00172.1 - 5.4 5.4 8.4 1.1 7.8 0.2 2.8 1 1 2 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1100) Pkinase_Tyr PF07714.12 ESA00173.1 - 1.2e-33 116.2 0.0 1.9e-33 115.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00173.1 - 2.1e-29 102.4 0.2 6.9e-29 100.7 0.0 1.8 1 1 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ESA00173.1 - 0.00054 19.0 0.0 0.00075 18.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA00173.1 - 0.0024 17.2 0.6 0.14 11.5 0.0 2.4 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA00173.1 - 0.0074 16.0 0.0 0.016 14.9 0.1 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA00173.1 - 0.035 13.1 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA00174.1 - 2.7e-108 352.0 46.9 3.3e-11 43.4 0.2 10.2 10 0 0 10 10 10 10 Sel1 repeat MIT PF04212.13 ESA00174.1 - 5.2e-10 39.0 27.0 0.96 9.3 0.4 9.3 8 2 1 9 9 9 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA00174.1 - 9.1e-10 38.3 24.9 3.4 8.3 0.0 10.1 10 0 0 10 10 10 2 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA00174.1 - 2.9e-06 27.1 0.0 1.1 8.8 0.0 4.4 1 1 1 3 3 3 2 Caspase domain TPR_20 PF14561.1 ESA00174.1 - 1.4e-05 25.1 1.4 21 5.3 0.0 5.9 2 2 4 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00174.1 - 2.1e-05 24.7 3.3 5.3 7.4 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA00174.1 - 8e-05 22.2 10.8 38 4.1 0.0 8.2 9 0 0 9 9 9 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA00174.1 - 0.00028 20.8 21.7 5.6 7.4 0.0 9.4 8 2 1 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00174.1 - 0.0058 17.2 6.0 10 6.9 0.0 6.2 3 2 7 10 10 10 0 Tetratricopeptide repeat HTH_16 PF12645.2 ESA00174.1 - 0.0058 16.5 2.7 9.4 6.2 0.0 5.0 5 0 0 5 5 5 0 Helix-turn-helix domain HEPN PF05168.9 ESA00174.1 - 0.015 15.1 8.5 0.6 10.0 1.2 4.0 2 2 1 3 3 3 0 HEPN domain TPR_12 PF13424.1 ESA00174.1 - 0.055 13.4 32.1 9.3 6.2 0.5 8.5 1 1 7 9 9 9 0 Tetratricopeptide repeat HTH_Tnp_IS1 PF12759.2 ESA00174.1 - 0.12 11.8 1.9 35 3.9 0.0 4.1 5 0 0 5 5 5 0 InsA C-terminal domain zinc-ribbons_6 PF07191.7 ESA00174.1 - 0.12 12.1 5.2 0.3 10.9 3.6 1.6 1 0 0 1 1 1 0 zinc-ribbons DUF3674 PF12426.3 ESA00174.1 - 0.13 11.7 21.4 15 5.0 0.0 7.0 8 0 0 8 8 8 0 RNA dependent RNA polymerase EcoRI PF02963.11 ESA00174.1 - 0.22 10.2 4.7 21 3.7 0.1 4.4 3 1 1 5 5 5 0 Restriction endonuclease EcoRI 23S_rRNA_IVP PF05635.6 ESA00174.1 - 1.2 9.0 7.2 15 5.5 0.1 3.7 3 2 3 6 6 6 0 23S rRNA-intervening sequence protein NUMOD1 PF07453.8 ESA00174.1 - 2.6 8.0 9.1 81 3.2 0.0 6.5 9 0 0 9 9 9 0 NUMOD1 domain Cytochrom_CIII PF02085.11 ESA00174.1 - 7.5 6.7 12.3 39 4.3 0.1 4.9 2 2 1 5 5 5 0 Class III cytochrome C family Sel1 PF08238.7 ESA00176.1 - 1.9e-38 129.9 12.1 5.6e-12 45.8 0.3 4.9 5 0 0 5 5 5 4 Sel1 repeat MIT PF04212.13 ESA00176.1 - 0.00032 20.5 6.1 1.5 8.7 0.2 3.3 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA00176.1 - 0.0017 18.6 3.1 13 6.4 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA00176.1 - 0.0067 16.1 1.2 12 5.6 0.0 3.2 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation TPR_10 PF13374.1 ESA00176.1 - 0.011 15.5 12.0 3.1 7.8 0.8 4.7 4 2 0 4 4 4 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 ESA00176.1 - 0.025 13.4 4.3 1.3 7.8 0.3 2.1 2 0 0 2 2 2 0 Spatacsin C-terminus Ph1570 PF09638.5 ESA00176.1 - 0.054 13.2 5.4 3.8 7.2 0.1 3.7 1 1 3 4 4 4 0 Ph1570 protein TPR_1 PF00515.23 ESA00176.1 - 0.52 10.0 12.7 5.3 6.8 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Leuk-A4-hydro_C PF09127.6 ESA00176.1 - 0.77 9.3 3.8 4.6 6.8 0.4 2.3 1 1 1 2 2 2 0 Leukotriene A4 hydrolase, C-terminal RAP-1 PF03085.10 ESA00176.1 - 0.83 8.9 6.7 10 5.3 0.2 2.9 1 1 2 3 3 3 0 Rhoptry-associated protein 1 (RAP-1) Hydrolase_2 PF07486.7 ESA00176.1 - 2.6 8.6 6.7 13 6.3 0.3 2.5 1 1 2 3 3 3 0 Cell Wall Hydrolase Apc3 PF12895.2 ESA00176.1 - 2.6 8.2 11.7 7.4 6.7 0.2 3.5 1 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ASFV_360 PF01671.11 ESA00176.1 - 2.8 7.2 6.7 7.6 5.8 0.2 2.6 1 1 1 2 2 2 0 African swine fever virus multigene family 360 protein GDYXXLXY PF14345.1 ESA00176.1 - 6.5 6.6 8.2 31 4.4 0.2 2.9 1 1 2 3 3 3 0 GDYXXLXY protein ACBP PF00887.14 ESA00177.1 - 0.065 12.9 0.0 0.078 12.6 0.0 1.3 1 0 0 1 1 1 0 Acyl CoA binding protein DUF1675 PF07897.6 ESA00178.1 - 0.011 15.6 0.4 0.015 15.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Nup35_RRM_2 PF14605.1 ESA00178.1 - 0.1 12.3 0.1 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SPRY PF00622.23 ESA00179.1 - 2.3e-10 40.6 0.4 4.4e-10 39.7 0.2 1.4 1 0 0 1 1 1 1 SPRY domain Amidase_2 PF01510.20 ESA00179.1 - 0.0049 16.9 0.1 0.0075 16.3 0.1 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase BTB PF00651.26 ESA00180.1 - 9e-08 32.0 1.6 2.6e-07 30.5 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA00180.1 - 9.1e-08 32.2 1.0 1.6e-07 31.4 0.7 1.3 1 0 0 1 1 1 1 SPRY domain Pkinase_Tyr PF07714.12 ESA00182.1 - 2.9e-26 92.0 0.0 3.5e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00182.1 - 3.2e-26 92.0 0.5 3.7e-26 91.8 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA00182.1 - 0.0086 15.8 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA00182.1 - 0.0092 15.2 0.6 0.014 14.6 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA00182.1 - 0.074 12.3 0.3 0.14 11.4 0.2 1.6 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESA00182.1 - 0.092 11.6 0.0 7.2 5.4 0.0 2.1 1 1 0 2 2 2 0 Kinase-like AntA PF08346.7 ESA00182.1 - 0.47 10.6 7.3 13 6.0 5.1 2.4 1 1 0 1 1 1 0 AntA/AntB antirepressor Myb_DNA-binding PF00249.26 ESA00184.1 - 0.00013 21.9 7.5 0.012 15.6 0.6 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA00184.1 - 0.055 14.1 9.6 1.3 9.7 3.2 2.5 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2611 PF11022.3 ESA00184.1 - 0.073 13.1 0.3 0.65 10.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2611) Myb_DNA-bind_6 PF13921.1 ESA00184.1 - 3.7 7.7 6.4 4.4 7.4 0.1 2.7 1 1 1 2 2 2 0 Myb-like DNA-binding domain WD40 PF00400.27 ESA00187.1 - 2.7e-20 71.4 0.2 3.5e-05 23.5 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 ESA00187.1 - 7.1e-07 29.1 1.8 0.2 11.3 0.0 4.6 4 1 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 ESA00187.1 - 0.029 14.1 0.3 2.5 7.9 0.0 3.2 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF3244 PF11589.3 ESA00188.1 - 0.0085 15.7 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3244) Pkinase PF00069.20 ESA00192.1 - 2e-40 138.5 0.1 2.5e-40 138.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00192.1 - 3.4e-37 127.9 0.0 4.5e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00192.1 - 0.00023 20.2 0.0 0.03 13.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.17 ESA00192.1 - 0.0033 16.7 0.3 0.007 15.7 0.2 1.7 1 1 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA00192.1 - 0.0039 16.4 0.3 0.006 15.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA00192.1 - 0.0057 16.4 0.1 0.0098 15.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA00192.1 - 0.066 12.2 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GFO_IDH_MocA PF01408.17 ESA00192.1 - 0.15 12.5 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Pkinase PF00069.20 ESA00193.1 - 3.2e-16 59.2 0.0 4.1e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00193.1 - 1.7e-12 46.9 0.0 3.8e-12 45.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3943 PF13084.1 ESA00194.1 - 0.18 11.3 0.8 0.82 9.2 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3943) Peptidase_M56 PF05569.6 ESA00195.1 - 0.0016 17.5 0.2 0.0021 17.0 0.1 1.1 1 0 0 1 1 1 1 BlaR1 peptidase M56 Glt_symporter PF03616.9 ESA00195.1 - 0.0026 16.3 0.1 0.0033 15.9 0.0 1.1 1 0 0 1 1 1 1 Sodium/glutamate symporter Herpes_gE PF02480.11 ESA00195.1 - 0.004 15.4 0.0 0.0057 14.9 0.0 1.3 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Podoplanin PF05808.6 ESA00195.1 - 0.0043 16.6 0.4 0.0071 15.9 0.3 1.3 1 0 0 1 1 1 1 Podoplanin Shisa PF13908.1 ESA00195.1 - 0.0053 16.9 2.5 0.013 15.7 1.7 1.7 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 ESA00195.1 - 0.0062 16.2 2.3 0.011 15.4 1.6 1.4 1 0 0 1 1 1 1 TMEM154 protein family Rax2 PF12768.2 ESA00195.1 - 0.016 14.3 0.1 0.021 14.0 0.1 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity OPA3 PF07047.7 ESA00195.1 - 0.018 14.8 0.1 0.024 14.3 0.1 1.2 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) IncA PF04156.9 ESA00195.1 - 0.099 12.2 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 IncA protein RAMP4 PF06624.7 ESA00195.1 - 0.41 10.2 5.0 0.18 11.3 1.1 2.1 2 1 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF448 PF04296.8 ESA00196.1 - 0.0013 18.2 0.0 0.0025 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF448) Leukemia_assc_2 PF15197.1 ESA00196.1 - 1.2 8.8 4.7 0.54 9.9 0.7 2.3 2 0 0 2 2 2 0 Leukemia-associated protein 2 PLDc_2 PF13091.1 ESA00197.1 - 2.5e-13 49.8 0.1 2.9e-06 27.0 0.0 2.8 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 ESA00197.1 - 0.0099 15.6 2.1 0.91 9.4 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Coat_F PF07875.7 ESA00197.1 - 0.055 13.5 0.8 0.15 12.1 0.6 1.7 1 0 0 1 1 1 0 Coat F domain Ecm29 PF13001.2 ESA00198.1 - 4.5e-133 444.3 0.5 1.2e-131 439.6 0.2 2.7 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.17 ESA00198.1 - 7.4e-15 53.6 1.8 0.094 12.8 0.0 10.2 9 0 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.1 ESA00198.1 - 4.7e-12 46.0 3.3 0.062 13.8 0.0 9.2 8 2 2 10 10 10 3 HEAT-like repeat HEAT_2 PF13646.1 ESA00198.1 - 6.8e-09 35.9 3.1 2.5 8.4 0.0 8.8 8 2 1 9 9 9 3 HEAT repeats Vac14_Fab1_bd PF12755.2 ESA00198.1 - 4.5e-07 30.1 2.0 0.88 9.9 0.0 7.0 7 1 1 8 8 8 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 ESA00198.1 - 4.8e-05 22.8 1.7 0.81 8.9 0.0 6.0 7 1 0 7 7 7 1 CLASP N terminal Cnd3 PF12719.2 ESA00198.1 - 0.0047 15.9 2.7 0.19 10.6 0.0 4.0 4 0 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain TIP120 PF08623.5 ESA00198.1 - 0.014 14.9 5.8 4.2 6.9 0.1 3.9 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Foamy_virus_ENV PF03408.9 ESA00199.1 - 0.12 9.8 0.7 0.15 9.6 0.5 1.0 1 0 0 1 1 1 0 Foamy virus envelope protein AA_kinase PF00696.23 ESA00200.1 - 5.2e-40 137.5 0.8 1.1e-39 136.4 0.6 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 ESA00200.1 - 1.6e-16 59.7 0.7 6.8e-16 57.7 0.5 2.2 1 0 0 1 1 1 1 PUA domain DnaJ PF00226.26 ESA00201.1 - 5.8e-22 77.2 1.5 1.3e-21 76.0 1.1 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESA00201.1 - 2.1e-16 59.8 1.6 5.2e-09 35.6 0.0 2.7 3 0 0 3 3 3 2 X-domain of DnaJ-containing Tctex-1 PF03645.8 ESA00201.1 - 0.034 13.9 0.2 0.1 12.4 0.1 1.8 1 0 0 1 1 1 0 Tctex-1 family GvpG PF05120.7 ESA00202.1 - 0.003 17.3 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Gas vesicle protein G tRNA_Me_trans PF03054.11 ESA00203.1 - 1.3e-20 73.2 0.0 1.4e-20 73.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase DUF4118 PF13493.1 ESA00206.1 - 0.011 15.9 2.8 0.051 13.7 2.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) KTSC PF13619.1 ESA00206.1 - 0.026 14.1 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 KTSC domain ClpB_D2-small PF10431.4 ESA00206.1 - 0.13 12.1 1.3 0.19 11.6 0.1 1.9 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein SieB PF14163.1 ESA00206.1 - 0.17 11.4 3.0 0.29 10.7 2.0 1.4 1 1 0 1 1 1 0 Superinfection exclusion protein B Fib_alpha PF08702.5 ESA00206.1 - 0.28 11.3 5.7 0.42 10.7 4.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Spore_YabQ PF09578.5 ESA00206.1 - 1.8 8.5 9.4 0.16 11.9 3.0 1.8 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) DUF2207 PF09972.4 ESA00206.1 - 3 6.3 6.8 0.45 9.0 2.0 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Pkinase PF00069.20 ESA00208.1 - 0.0001 21.5 0.0 0.00012 21.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH_6_hur PF04655.9 ESA00208.1 - 0.032 13.3 0.1 0.037 13.1 0.1 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Kdo PF06293.9 ESA00208.1 - 0.037 13.1 0.1 0.045 12.8 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA00208.1 - 0.097 12.3 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA00208.1 - 0.1 11.5 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Pkinase_Tyr PF07714.12 ESA00208.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.20 ESA00209.1 - 1.8e-45 155.1 0.1 6.9e-45 153.2 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00209.1 - 2e-20 72.9 0.0 5.9e-19 68.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00209.1 - 3.2e-07 29.6 0.0 8.6e-05 21.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Choline_kinase PF01633.15 ESA00209.1 - 0.00054 19.6 0.2 0.00086 18.9 0.2 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA00209.1 - 0.0012 18.6 0.0 0.34 10.6 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family HAT PF02184.11 ESA00210.1 - 4.2e-34 115.9 57.2 1.2e-16 60.1 3.0 14.6 15 1 0 15 15 15 6 HAT (Half-A-TPR) repeat TPR_16 PF13432.1 ESA00210.1 - 1.4e-20 73.4 11.0 0.033 14.8 0.0 8.6 6 2 2 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00210.1 - 5.3e-18 65.1 2.6 0.87 9.9 0.0 8.5 5 1 4 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00210.1 - 3.5e-16 58.2 19.8 0.33 11.7 0.0 12.9 5 3 10 15 15 13 4 Tetratricopeptide repeat Suf PF05843.9 ESA00210.1 - 1.3e-11 44.8 47.1 7.3e-05 22.6 3.3 7.6 3 2 4 8 8 8 4 Suppressor of forked protein (Suf) TPR_12 PF13424.1 ESA00210.1 - 1.5e-08 34.4 20.1 0.16 11.8 0.2 8.4 8 2 1 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00210.1 - 6.9e-07 28.9 11.7 0.00096 19.1 0.1 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00210.1 - 3.6e-06 26.4 28.4 2.5 8.2 0.0 11.1 13 0 0 13 13 13 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00210.1 - 6.7e-05 23.0 21.5 1.9 9.1 0.0 10.0 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00210.1 - 0.00033 20.2 26.4 0.33 10.6 0.1 7.2 8 1 1 9 9 8 3 TPR repeat U3_assoc_6 PF08640.6 ESA00210.1 - 2.6 7.8 32.8 0.12 12.0 0.2 8.6 6 3 3 9 9 9 0 U3 small nucleolar RNA-associated protein 6 TPR_1 PF00515.23 ESA00210.1 - 3.8 7.2 17.7 10 5.9 0.0 7.4 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00210.1 - 4 7.4 16.9 3.8 7.5 0.0 6.6 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA00210.1 - 5.1 7.1 18.4 23 5.0 0.0 7.8 10 0 0 10 10 9 0 Tetratricopeptide repeat DOCK-C2 PF14429.1 ESA00211.1 - 4.4e-46 156.8 1.5 8.8e-46 155.8 1.0 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Ded_cyto PF06920.8 ESA00211.1 - 2.5e-43 147.4 0.0 8.2e-43 145.7 0.0 2.0 1 0 0 1 1 1 1 Dedicator of cytokinesis SH3_3 PF08239.6 ESA00211.1 - 0.071 13.3 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain DUF2884 PF11101.3 ESA00212.1 - 0.0035 16.7 0.7 0.004 16.5 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2884) Baculo_PEP_C PF04513.7 ESA00212.1 - 0.005 16.6 0.6 0.0057 16.4 0.4 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.7 ESA00212.1 - 0.017 14.9 1.7 0.019 14.7 1.2 1.0 1 0 0 1 1 1 0 LXG domain of WXG superfamily UPF0184 PF03670.8 ESA00212.1 - 0.026 14.6 1.2 0.031 14.4 0.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) TBPIP PF07106.8 ESA00212.1 - 0.042 13.4 4.4 0.044 13.3 3.1 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MtrG PF04210.8 ESA00212.1 - 0.067 12.8 0.8 0.14 11.8 0.6 1.7 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Vip3A_N PF12495.3 ESA00212.1 - 0.094 12.3 0.9 0.12 12.0 0.6 1.2 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Flagellin_N PF00669.15 ESA00212.1 - 0.1 12.4 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region DUF4358 PF14270.1 ESA00212.1 - 0.1 12.4 0.5 0.13 12.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4358) EMP24_GP25L PF01105.19 ESA00212.1 - 0.19 11.4 0.4 0.2 11.3 0.3 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD NPV_P10 PF05531.7 ESA00212.1 - 0.19 11.9 2.7 0.28 11.4 1.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3355 PF11835.3 ESA00212.1 - 0.21 11.3 1.2 0.25 11.1 0.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3355) HSCB_C PF07743.8 ESA00212.1 - 0.27 11.7 2.9 0.36 11.3 2.0 1.2 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain PKI PF02827.11 ESA00212.1 - 5.4 7.2 5.7 1.8 8.7 2.3 1.4 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor dsrm PF00035.20 ESA00213.1 - 1.8e-10 41.2 1.5 0.01 16.3 0.0 4.4 4 0 0 4 4 4 3 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ESA00213.1 - 3.1e-08 33.7 1.3 0.023 15.0 0.0 3.7 3 0 0 3 3 3 3 double strand RNA binding domain from DEAD END PROTEIN 1 MTHFR PF02219.12 ESA00214.1 - 3.5e-120 400.4 0.0 4.9e-120 399.9 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Rpr2 PF04032.11 ESA00215.1 - 2.8e-17 62.3 9.6 2.8e-17 62.3 6.7 2.9 2 2 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain E7 PF00527.13 ESA00215.1 - 0.014 15.5 1.1 0.014 15.5 0.7 2.3 2 0 0 2 2 2 0 E7 protein, Early protein Pectate_lyase_3 PF12708.2 ESA00215.1 - 0.066 13.3 3.0 0.09 12.8 2.1 1.2 1 0 0 1 1 1 0 Pectate lyase superfamily protein Per1 PF04080.8 ESA00216.1 - 2.1e-96 322.4 16.4 2.7e-96 322.1 11.4 1.1 1 0 0 1 1 1 1 Per1-like Dimer_Tnp_hAT PF05699.9 ESA00218.1 - 5e-16 58.0 0.1 8.7e-16 57.3 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Leader_Trp PF08255.6 ESA00218.1 - 0.093 12.4 2.3 4.9 7.0 0.2 2.8 2 0 0 2 2 2 0 Trp-operon Leader Peptide Dimer_Tnp_hAT PF05699.9 ESA00219.1 - 3e-15 55.6 0.1 3.1e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-B_box PF00643.19 ESA00220.1 - 0.39 10.6 7.5 0.71 9.8 0.1 3.0 3 0 0 3 3 3 0 B-box zinc finger CBM_10 PF02013.11 ESA00220.1 - 2.8 8.2 6.3 18 5.7 4.4 2.3 1 1 0 1 1 1 0 Cellulose or protein binding domain ZZ PF00569.12 ESA00220.1 - 3.4 7.2 6.7 4.2 6.9 0.1 3.2 3 0 0 3 3 3 0 Zinc finger, ZZ type zf-UBR PF02207.15 ESA00220.1 - 4.7 7.0 6.4 22 4.8 1.5 2.7 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) tRNA_bind PF01588.15 ESA00221.1 - 5.8e-15 54.9 0.0 8.5e-12 44.7 0.0 2.2 2 0 0 2 2 2 2 Putative tRNA binding domain FTR_C PF02741.10 ESA00221.1 - 0.0053 16.5 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 FTR, proximal lobe zf-U1 PF06220.7 ESA00222.1 - 9.3e-21 73.1 6.7 1.3e-20 72.6 4.7 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 ESA00222.1 - 0.00027 20.9 3.1 0.0005 20.1 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF2680 PF10925.3 ESA00222.1 - 0.095 12.5 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) NDUF_B7 PF05676.8 ESA00223.1 - 1.2e-30 104.7 4.0 1.3e-30 104.6 2.8 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.5 ESA00223.1 - 0.00036 20.2 1.4 0.00039 20.1 1.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF3228 PF11539.3 ESA00223.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) Ribosomal_L33 PF00471.15 ESA00224.1 - 6.4e-07 29.5 0.0 8.8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 Nop PF01798.13 ESA00226.1 - 5.8e-45 152.2 0.1 1e-44 151.4 0.1 1.4 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 ESA00226.1 - 8.3e-38 129.6 0.3 8.3e-38 129.6 0.2 1.7 2 0 0 2 2 2 1 Prp31 C terminal domain NOSIC PF08060.8 ESA00226.1 - 6.4e-22 77.1 0.2 1.6e-21 75.7 0.1 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain Rota_VP2 PF05087.7 ESA00226.1 - 4.2 5.1 11.1 5.9 4.6 7.7 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein zf-C2H2_jaz PF12171.3 ESA00227.1 - 0.0023 18.0 0.4 0.0041 17.2 0.3 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESA00227.1 - 0.003 17.7 0.3 0.0054 16.9 0.2 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA00227.1 - 0.01 16.1 0.2 0.018 15.3 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 ESA00227.1 - 0.011 15.8 0.1 0.014 15.4 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 ESA00227.1 - 0.033 14.4 0.1 0.051 13.7 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Ecl1 PF12855.2 ESA00227.1 - 0.039 13.2 0.2 0.086 12.1 0.1 1.5 1 0 0 1 1 1 0 Life-span regulatory factor DDE_1 PF03184.14 ESA00229.1 - 3.9e-25 88.2 4.0 4.2e-20 71.8 0.3 3.4 3 1 1 4 4 4 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA00229.1 - 4.7e-06 26.3 0.0 4.7e-06 26.3 0.0 2.7 3 1 1 4 4 4 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA00229.1 - 0.058 13.1 1.1 0.13 11.9 0.1 2.1 3 0 0 3 3 3 0 DDE superfamily endonuclease DUF2536 PF10750.4 ESA00230.1 - 0.014 14.9 0.0 0.037 13.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) YniB PF14002.1 ESA00230.1 - 0.022 14.2 0.1 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 YniB-like protein FtsK_SpoIIIE_N PF12538.3 ESA00231.1 - 0.14 12.2 1.0 0.63 10.1 0.1 2.1 2 0 0 2 2 2 0 DNA transporter DUF4367 PF14285.1 ESA00231.1 - 1.3 8.2 6.0 0.96 8.7 0.2 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4367) Siah-Interact_N PF09032.6 ESA00232.1 - 8.2 6.5 7.7 13 5.9 0.6 2.5 3 0 0 3 3 3 0 Siah interacting protein, N terminal Gly_transf_sug PF04488.10 ESA00233.1 - 0.18 12.2 4.5 0.32 11.4 0.6 3.1 2 1 0 2 2 2 0 Glycosyltransferase sugar-binding region containing DXD motif Ion_trans PF00520.26 ESA00234.1 - 4e-10 39.2 14.9 4e-10 39.2 10.3 3.1 1 1 0 2 2 2 1 Ion transport protein ADH_zinc_N PF00107.21 ESA00235.1 - 1.2e-06 28.0 0.1 1.9e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pkinase PF00069.20 ESA00236.1 - 3.5e-09 36.1 0.1 4.4e-09 35.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00236.1 - 6.8e-08 31.8 0.0 8e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ESA00236.1 - 0.012 15.5 0.0 0.082 12.8 0.0 2.0 1 1 1 2 2 2 0 ABC1 family Orthopox_F7 PF05813.7 ESA00236.1 - 0.06 13.2 0.1 0.08 12.8 0.1 1.3 1 1 0 1 1 1 0 Orthopoxvirus F7 protein FTA2 PF13095.1 ESA00236.1 - 0.11 12.0 1.0 0.11 12.0 0.7 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PilX PF13681.1 ESA00237.1 - 0.006 17.0 0.7 0.0082 16.6 0.5 1.2 1 0 0 1 1 1 1 Type IV pilus assembly protein PilX C-term CUE PF02845.11 ESA00237.1 - 0.046 13.2 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 CUE domain Sas10 PF09368.5 ESA00237.1 - 0.43 10.7 3.9 0.82 9.8 2.5 1.7 1 1 1 2 2 2 0 Sas10 C-terminal domain DUF1419 PF07215.6 ESA00239.1 - 0.11 12.3 0.1 0.27 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1419) GAS PF13851.1 ESA00241.1 - 0.0031 16.7 7.3 0.0034 16.6 5.1 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DivIC PF04977.10 ESA00241.1 - 0.0076 15.7 11.8 0.11 12.0 4.4 2.7 1 1 1 2 2 2 1 Septum formation initiator EzrA PF06160.7 ESA00241.1 - 0.0082 14.3 5.0 0.0084 14.3 3.5 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA TSC22 PF01166.13 ESA00241.1 - 0.021 14.7 9.5 0.18 11.8 3.2 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family bZIP_1 PF00170.16 ESA00241.1 - 0.026 14.4 10.5 0.35 10.8 2.7 2.6 1 1 2 3 3 3 0 bZIP transcription factor Atg14 PF10186.4 ESA00241.1 - 0.038 12.9 6.1 0.042 12.7 4.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cortex-I_coil PF09304.5 ESA00241.1 - 0.04 13.9 5.9 0.057 13.4 4.1 1.3 1 0 0 1 1 1 0 Cortexillin I, coiled coil TBPIP PF07106.8 ESA00241.1 - 0.043 13.3 3.2 0.047 13.2 2.2 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tup_N PF08581.5 ESA00241.1 - 0.044 13.9 5.5 3.5 7.8 0.1 2.0 1 1 0 1 1 1 0 Tup N-terminal HAP1_N PF04849.8 ESA00241.1 - 0.046 12.6 6.6 0.82 8.5 0.8 2.0 1 1 1 2 2 2 0 HAP1 N-terminal conserved region ADIP PF11559.3 ESA00241.1 - 0.049 13.5 4.6 0.057 13.3 3.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.3 ESA00241.1 - 0.049 13.3 7.8 0.13 11.9 5.4 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Nup54 PF13874.1 ESA00241.1 - 0.069 12.8 3.0 0.078 12.6 2.1 1.1 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Fzo_mitofusin PF04799.8 ESA00241.1 - 0.07 12.5 2.1 0.069 12.5 1.1 1.3 1 1 0 1 1 1 0 fzo-like conserved region DUF972 PF06156.8 ESA00241.1 - 0.073 13.4 4.1 0.094 13.0 2.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 ESA00241.1 - 0.074 12.6 6.8 0.082 12.4 4.7 1.0 1 0 0 1 1 1 0 IncA protein BLOC1_2 PF10046.4 ESA00241.1 - 0.084 13.0 1.5 0.11 12.6 1.1 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.6 ESA00241.1 - 0.094 11.3 3.9 0.095 11.3 2.7 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Cob_adeno_trans PF01923.13 ESA00241.1 - 0.1 12.3 0.7 0.13 12.0 0.5 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase PKK PF12474.3 ESA00241.1 - 0.11 12.1 5.9 0.13 11.9 4.1 1.1 1 0 0 1 1 1 0 Polo kinase kinase bZIP_2 PF07716.10 ESA00241.1 - 0.13 12.1 13.8 0.13 12.1 2.7 2.4 1 1 0 2 2 2 0 Basic region leucine zipper CASP_C PF08172.7 ESA00241.1 - 0.14 11.1 7.4 0.2 10.6 1.8 2.0 1 1 1 2 2 2 0 CASP C terminal TMF_DNA_bd PF12329.3 ESA00241.1 - 0.15 11.9 10.3 3.2 7.6 7.0 2.1 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4337 PF14235.1 ESA00241.1 - 0.19 11.5 3.6 0.21 11.4 2.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF2570 PF10828.3 ESA00241.1 - 0.25 10.9 4.7 0.31 10.6 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Ax_dynein_light PF10211.4 ESA00241.1 - 0.27 11.0 7.1 0.32 10.8 4.9 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain PEARLI-4 PF05278.7 ESA00241.1 - 0.35 10.1 4.7 0.39 10.0 3.2 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF904 PF06005.7 ESA00241.1 - 0.41 10.9 10.4 0.89 9.8 3.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Macoilin PF09726.4 ESA00241.1 - 0.44 8.7 3.3 0.49 8.6 2.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Viral_P18 PF04521.8 ESA00241.1 - 0.67 9.4 5.5 15 5.0 4.4 2.0 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Lge1 PF11488.3 ESA00241.1 - 0.69 10.1 2.8 1.3 9.2 1.0 1.8 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 MerR-DNA-bind PF09278.6 ESA00241.1 - 0.85 10.0 12.5 6.8 7.1 3.3 2.6 1 1 2 3 3 3 0 MerR, DNA binding Osmo_CC PF08946.5 ESA00241.1 - 0.86 9.6 9.9 1.9 8.5 2.1 2.9 1 1 2 3 3 3 0 Osmosensory transporter coiled coil DUF3166 PF11365.3 ESA00241.1 - 0.91 10.0 7.4 7.7 7.0 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) TPR_MLP1_2 PF07926.7 ESA00241.1 - 1.3 8.8 10.8 1.8 8.3 7.5 1.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Pox_A_type_inc PF04508.7 ESA00241.1 - 1.4 8.8 7.2 0.61 10.0 0.6 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Prefoldin PF02996.12 ESA00241.1 - 1.4 8.5 6.0 7.2 6.2 0.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF4200 PF13863.1 ESA00241.1 - 1.9 8.4 11.8 5.7 6.9 4.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) NYD-SP28_assoc PF14775.1 ESA00241.1 - 2.9 7.6 10.2 0.87 9.3 0.4 2.7 1 1 2 3 3 3 0 Sperm tail C-terminal domain Caldesmon PF02029.10 ESA00241.1 - 3.2 6.0 7.3 3.3 6.0 5.0 1.1 1 0 0 1 1 1 0 Caldesmon Ead_Ea22 PF13935.1 ESA00241.1 - 3.5 7.9 7.8 4.6 7.5 5.4 1.1 1 0 0 1 1 1 0 Ead/Ea22-like protein Mto2_bdg PF12808.2 ESA00241.1 - 4.2 7.5 11.6 1.3 9.2 0.3 2.9 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region WD40_alt PF14077.1 ESA00241.1 - 5 6.8 6.2 2.5 7.7 1.9 2.2 1 1 1 2 2 2 0 Alternative WD40 repeat motif CCDC92 PF14916.1 ESA00241.1 - 5.7 6.6 11.3 4.9 6.8 0.2 3.0 1 1 2 3 3 3 0 Coiled-coil domain of unknown function GRASP55_65 PF04495.9 ESA00245.1 - 7.9e-70 233.2 0.0 4e-54 182.3 0.0 2.3 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.1 ESA00245.1 - 0.0058 16.5 0.0 0.07 13.0 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PFK PF00365.15 ESA00246.1 - 3.1e-176 584.1 1.2 3e-121 403.7 0.7 2.1 2 0 0 2 2 2 2 Phosphofructokinase MIR PF02815.14 ESA00248.1 - 0.0013 18.3 0.8 0.057 12.9 0.0 2.3 1 1 1 2 2 2 2 MIR domain Ribosomal_L10 PF00466.15 ESA00248.1 - 0.0015 18.4 0.3 0.87 9.5 0.0 2.5 2 0 0 2 2 2 2 Ribosomal protein L10 FlaC_arch PF05377.6 ESA00252.1 - 0.01 15.7 3.3 0.095 12.6 0.3 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.7 ESA00252.1 - 0.012 15.4 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 ESA00252.1 - 0.06 13.4 0.2 0.077 13.1 0.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Cortex-I_coil PF09304.5 ESA00252.1 - 0.068 13.2 0.4 0.087 12.8 0.3 1.1 1 0 0 1 1 1 0 Cortexillin I, coiled coil ORF6C PF10552.4 ESA00252.1 - 0.072 12.8 1.8 4 7.1 0.1 2.2 1 1 1 2 2 2 0 ORF6C domain TPR_MLP1_2 PF07926.7 ESA00252.1 - 0.075 12.7 0.0 0.099 12.3 0.0 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1515 PF07439.6 ESA00252.1 - 0.12 12.2 1.3 2.1 8.1 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) NPV_P10 PF05531.7 ESA00252.1 - 0.13 12.5 0.4 3.6 7.9 0.1 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.4 ESA00252.1 - 0.19 11.8 1.7 1.2 9.3 1.2 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Hemagglutinin PF00509.13 ESA00252.1 - 0.24 9.4 2.5 0.3 9.1 1.7 1.1 1 0 0 1 1 1 0 Haemagglutinin Ribosomal_S30AE PF02482.14 ESA00255.1 - 0.13 12.7 0.1 0.32 11.4 0.0 1.6 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein LRR_6 PF13516.1 ESA00256.1 - 5.2e-11 41.4 1.6 9.2e-05 22.1 0.0 5.0 5 1 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.2 ESA00256.1 - 3.4e-07 29.7 0.8 0.0038 16.7 0.3 4.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA00256.1 - 4.7e-07 29.4 0.4 0.00025 20.7 0.0 3.5 2 1 1 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESA00256.1 - 1.1e-06 27.7 9.5 0.14 12.2 0.0 5.4 5 1 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ESA00256.1 - 0.0041 17.0 6.2 1.3 9.5 0.0 5.3 6 0 0 6 6 6 1 Leucine rich repeat Adeno_E4_34 PF04528.8 ESA00256.1 - 0.33 10.5 7.8 0.14 11.6 0.7 2.4 1 1 0 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region HTH_28 PF13518.1 ESA00257.1 - 0.0023 17.8 0.2 0.003 17.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF2764 PF10962.3 ESA00257.1 - 0.076 12.2 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) Pil1 PF13805.1 ESA00259.1 - 3.4e-54 183.8 0.6 3.4e-54 183.8 0.4 2.2 2 1 0 2 2 2 1 Eisosome component PIL1 ATG16 PF08614.6 ESA00259.1 - 1.6e-05 24.8 10.5 1.6e-05 24.8 7.3 3.4 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) AAA_13 PF13166.1 ESA00259.1 - 1.6e-05 23.6 34.1 0.0004 19.0 15.6 2.1 2 0 0 2 2 2 2 AAA domain TMF_DNA_bd PF12329.3 ESA00259.1 - 0.00046 19.9 10.3 0.00046 19.9 7.1 5.4 5 1 1 6 6 6 1 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.7 ESA00259.1 - 0.0023 17.7 21.3 0.12 12.1 0.2 4.8 2 2 2 5 5 5 3 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.7 ESA00259.1 - 0.0057 16.4 3.2 0.0057 16.4 2.2 3.6 3 1 0 3 3 3 1 Laminin Domain II Reo_sigmaC PF04582.7 ESA00259.1 - 0.026 13.7 14.8 0.014 14.6 3.3 3.2 2 2 2 4 4 4 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 ESA00259.1 - 0.032 14.0 23.6 0.13 12.0 4.1 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DUF3584 PF12128.3 ESA00259.1 - 0.14 9.5 30.0 0.009 13.4 13.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) SF-assemblin PF06705.6 ESA00259.1 - 0.25 10.4 28.6 0.63 9.1 11.3 2.4 2 0 0 2 2 2 0 SF-assemblin/beta giardin FlaC_arch PF05377.6 ESA00259.1 - 0.3 11.0 7.3 12 5.9 0.7 4.1 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) HR1 PF02185.11 ESA00259.1 - 0.3 10.8 17.1 3.7 7.3 0.8 4.6 4 1 0 4 4 4 0 Hr1 repeat DUF948 PF06103.6 ESA00259.1 - 0.4 10.5 15.2 0.059 13.2 2.4 3.8 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF148 PF02520.12 ESA00259.1 - 0.46 10.2 23.9 2.7 7.7 4.6 4.2 2 2 1 3 3 3 0 Domain of unknown function DUF148 Filament PF00038.16 ESA00259.1 - 0.48 9.8 29.2 1.8 7.9 14.8 3.3 2 1 0 2 2 2 0 Intermediate filament protein DUF2400 PF09674.5 ESA00259.1 - 0.54 9.9 11.8 1.6 8.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2400) NPV_P10 PF05531.7 ESA00259.1 - 0.93 9.7 19.5 0.34 11.1 2.9 4.6 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 ESA00259.1 - 1.1 8.8 34.0 0.44 10.1 1.6 3.6 2 2 1 3 3 3 0 IncA protein ADIP PF11559.3 ESA00259.1 - 6.4 6.6 32.3 0.36 10.7 6.7 4.2 2 2 2 5 5 5 0 Afadin- and alpha -actinin-Binding ABC_membrane PF00664.18 ESA00260.1 - 4.2e-92 308.4 30.6 8.1e-48 163.2 9.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA00260.1 - 3.2e-72 241.2 1.0 5.4e-36 123.9 0.1 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA00260.1 - 3.4e-16 59.1 0.0 1.2e-06 27.9 0.0 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 ESA00260.1 - 1.1e-10 40.7 2.2 0.00068 18.3 0.0 3.8 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 ESA00260.1 - 3.9e-09 35.8 0.6 0.00031 20.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 ESA00260.1 - 4.5e-09 36.6 13.9 0.02 14.8 0.0 6.2 4 2 1 6 6 6 3 AAA domain AAA_17 PF13207.1 ESA00260.1 - 2.8e-08 34.5 0.0 0.019 15.7 0.0 3.1 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 ESA00260.1 - 8.7e-08 31.5 0.1 0.006 15.7 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESA00260.1 - 1.1e-06 28.8 7.1 0.02 15.0 0.3 4.7 3 2 0 3 3 3 2 AAA domain AAA_16 PF13191.1 ESA00260.1 - 1.6e-06 28.2 2.4 0.018 15.0 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 ESA00260.1 - 4.7e-06 26.9 0.1 0.3 11.4 0.0 4.1 4 0 0 4 4 4 2 AAA domain SbcCD_C PF13558.1 ESA00260.1 - 5.6e-06 26.1 1.7 0.15 11.9 0.1 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.7 ESA00260.1 - 6e-06 25.4 0.0 0.0026 16.9 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin G-alpha PF00503.15 ESA00260.1 - 6.7e-06 25.0 2.2 0.0015 17.3 0.8 2.8 2 1 0 2 2 2 1 G-protein alpha subunit AAA_5 PF07728.9 ESA00260.1 - 3.1e-05 23.7 0.0 0.36 10.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 ESA00260.1 - 4.6e-05 23.1 0.2 0.072 12.7 0.0 2.6 2 0 0 2 2 2 2 Adenylylsulphate kinase DUF87 PF01935.12 ESA00260.1 - 4.7e-05 23.3 12.1 7e-05 22.7 0.0 3.9 4 1 0 4 4 4 1 Domain of unknown function DUF87 AAA_25 PF13481.1 ESA00260.1 - 0.00025 20.4 3.7 0.016 14.6 0.2 3.5 2 2 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESA00260.1 - 0.00039 20.0 1.3 1.8 8.0 0.0 3.9 4 1 0 4 4 3 2 AAA domain AAA_10 PF12846.2 ESA00260.1 - 0.0016 17.9 1.4 1.5 8.1 0.0 4.0 4 0 0 4 4 4 1 AAA-like domain Sigma54_activ_2 PF14532.1 ESA00260.1 - 0.0032 17.5 0.0 2.9 7.9 0.0 3.7 3 0 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activat PF00158.21 ESA00260.1 - 0.0047 16.4 0.0 3 7.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.17 ESA00260.1 - 0.0055 16.8 1.1 11 6.2 0.0 4.0 4 0 0 4 4 3 0 RNA helicase Mg_chelatase PF01078.16 ESA00260.1 - 0.0062 15.7 0.0 1.3 8.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESA00260.1 - 0.01 15.6 0.0 3.1 7.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 ESA00260.1 - 0.016 14.8 0.6 5.2 6.7 0.0 3.5 3 0 0 3 3 3 0 NACHT domain NB-ARC PF00931.17 ESA00260.1 - 0.019 13.8 1.2 0.66 8.7 0.2 2.6 2 1 0 2 2 2 0 NB-ARC domain FtsK_SpoIIIE PF01580.13 ESA00260.1 - 0.028 13.9 0.0 3.9 6.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family CPT PF07931.7 ESA00260.1 - 0.097 12.2 0.1 5.6 6.5 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein MobB PF03205.9 ESA00260.1 - 0.16 11.6 1.6 19 4.9 0.0 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 ESA00261.1 - 1.9e-54 183.3 0.0 4.8e-37 127.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA00261.1 - 6.7e-11 42.5 0.4 0.00082 19.3 0.0 3.7 2 2 2 4 4 4 2 AAA ATPase domain AAA_22 PF13401.1 ESA00261.1 - 1.4e-10 41.4 2.0 0.0014 18.7 0.2 4.1 2 2 1 3 3 3 2 AAA domain AAA_17 PF13207.1 ESA00261.1 - 7e-10 39.7 0.0 0.00095 19.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 ESA00261.1 - 1.6e-09 37.1 0.0 1.4e-05 24.1 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF815) AAA_5 PF07728.9 ESA00261.1 - 7.7e-09 35.4 0.3 0.0044 16.7 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 ESA00261.1 - 1.6e-08 34.1 0.0 0.0012 18.2 0.0 2.8 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_14 PF13173.1 ESA00261.1 - 2.4e-07 30.6 0.0 0.012 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 ESA00261.1 - 4.4e-07 29.1 0.1 0.00025 20.1 0.0 3.5 4 0 0 4 4 4 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESA00261.1 - 4.6e-07 29.4 0.3 0.0022 17.6 0.0 3.2 4 0 0 4 4 2 2 Part of AAA domain TIP49 PF06068.8 ESA00261.1 - 7.8e-07 28.1 0.2 9e-05 21.3 0.0 2.5 3 0 0 3 3 3 1 TIP49 C-terminus RNA_helicase PF00910.17 ESA00261.1 - 8.6e-07 29.1 0.0 0.042 14.0 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Sigma54_activat PF00158.21 ESA00261.1 - 2.9e-06 26.8 0.0 0.12 11.8 0.0 2.8 3 0 0 3 3 2 2 Sigma-54 interaction domain AAA_33 PF13671.1 ESA00261.1 - 3.3e-06 27.0 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 ESA00261.1 - 6e-06 26.3 0.0 0.041 13.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 ESA00261.1 - 1.4e-05 24.6 1.3 0.24 10.7 0.2 3.3 2 1 1 3 3 3 2 AAA domain Mg_chelatase PF01078.16 ESA00261.1 - 2.1e-05 23.7 0.0 0.012 14.7 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 ESA00261.1 - 2.7e-05 24.4 0.1 0.12 12.6 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_24 PF13479.1 ESA00261.1 - 5.2e-05 22.9 4.3 0.04 13.4 0.1 2.9 3 0 0 3 3 3 2 AAA domain PhoH PF02562.11 ESA00261.1 - 7.9e-05 21.9 0.0 0.051 12.8 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Sigma54_activ_2 PF14532.1 ESA00261.1 - 9e-05 22.5 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.22 ESA00261.1 - 0.00011 22.5 0.1 0.14 12.4 0.0 3.1 3 0 0 3 3 2 1 ABC transporter Bac_DnaA PF00308.13 ESA00261.1 - 0.00015 21.4 0.1 0.14 11.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial dnaA protein Guanylate_kin PF00625.16 ESA00261.1 - 0.00016 21.2 1.5 0.89 8.9 0.0 3.8 3 1 1 4 4 4 2 Guanylate kinase KaiC PF06745.8 ESA00261.1 - 0.0002 20.5 1.1 0.054 12.5 0.0 2.9 3 0 0 3 3 3 1 KaiC AAA_30 PF13604.1 ESA00261.1 - 0.00022 20.8 0.0 0.76 9.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ESA00261.1 - 0.00023 20.9 0.3 2.3 7.8 0.0 3.7 2 2 1 3 3 3 1 Archaeal ATPase AAA_11 PF13086.1 ESA00261.1 - 0.00043 19.9 0.0 0.056 13.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESA00261.1 - 0.00063 19.4 0.1 0.4 10.3 0.0 2.9 2 1 0 2 2 2 1 NACHT domain AAA_2 PF07724.9 ESA00261.1 - 0.00086 19.2 0.0 0.33 10.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) T2SE PF00437.15 ESA00261.1 - 0.001 18.0 0.0 1.4 7.7 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein UPF0079 PF02367.12 ESA00261.1 - 0.0012 18.4 0.0 1.5 8.4 0.0 3.0 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 cobW PF02492.14 ESA00261.1 - 0.002 17.5 0.0 0.17 11.3 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 ESA00261.1 - 0.0028 17.1 0.0 3.4 7.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Kinesin PF00225.18 ESA00261.1 - 0.003 16.3 0.0 0.042 12.5 0.0 2.5 2 1 0 2 2 2 1 Kinesin motor domain Zeta_toxin PF06414.7 ESA00261.1 - 0.0036 16.4 0.0 0.45 9.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_3 PF07726.6 ESA00261.1 - 0.0046 16.5 0.0 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.5 ESA00261.1 - 0.0093 15.2 0.0 2.2 7.4 0.0 2.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF2075 PF09848.4 ESA00261.1 - 0.01 14.8 0.0 0.72 8.7 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 ESA00261.1 - 0.011 15.1 0.0 2.4 7.5 0.0 2.6 2 1 0 2 2 2 0 AAA-like domain PIF1 PF05970.9 ESA00261.1 - 0.029 13.3 0.5 1.4 7.7 0.0 2.6 3 0 0 3 3 3 0 PIF1-like helicase Parvo_NS1 PF01057.12 ESA00261.1 - 0.033 13.0 0.0 0.13 11.1 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 ESA00261.1 - 0.033 13.0 0.1 0.4 9.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain DUF258 PF03193.11 ESA00261.1 - 0.043 13.0 0.0 2.6 7.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ResIII PF04851.10 ESA00261.1 - 0.051 13.4 0.0 8.4 6.1 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.10 ESA00261.1 - 0.059 13.0 0.0 15 5.2 0.0 2.6 2 0 0 2 2 2 0 NTPase Vps4_C PF09336.5 ESA00261.1 - 0.064 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain BACK PF07707.10 ESA00261.1 - 0.24 11.2 1.4 1 9.2 0.1 2.5 3 0 0 3 3 2 0 BTB And C-terminal Kelch AAA_23 PF13476.1 ESA00261.1 - 0.56 10.5 11.1 24 5.1 0.0 4.0 3 1 0 3 3 3 0 AAA domain polyprenyl_synt PF00348.12 ESA00262.1 - 3.1e-55 186.8 0.0 1.2e-51 175.0 0.0 2.2 2 0 0 2 2 2 2 Polyprenyl synthetase HEPPP_synt_1 PF07307.6 ESA00262.1 - 0.0064 15.9 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Spore_YunB PF09560.5 ESA00262.1 - 0.034 13.8 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein YunB (Spo_YunB) Na_Ca_ex PF01699.19 ESA00263.1 - 3.3e-14 52.6 6.6 3.9e-14 52.4 4.6 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF373 PF04123.8 ESA00263.1 - 0.085 11.8 2.1 0.1 11.5 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF4401 PF14351.1 ESA00263.1 - 0.12 11.3 5.3 0.027 13.4 0.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4401) DDDD PF10161.4 ESA00263.1 - 0.15 11.6 0.1 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative mitochondrial precursor protein DUF4231 PF14015.1 ESA00263.1 - 0.23 11.4 0.9 1.5 8.8 0.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) DUF3981 PF13139.1 ESA00263.1 - 0.92 9.5 4.1 3.9 7.5 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3981) DUF4413 PF14372.1 ESA00265.1 - 0.00035 20.5 0.3 0.0035 17.3 0.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4413) DUF2791 PF10923.3 ESA00265.1 - 0.03 12.9 0.0 0.042 12.4 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) F-box-like PF12937.2 ESA00266.1 - 0.0018 17.9 0.7 0.0047 16.6 0.1 2.0 2 0 0 2 2 2 1 F-box-like Dimer_Tnp_hAT PF05699.9 ESA00267.1 - 9.5e-14 50.8 0.0 1.1e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region UBN2_3 PF14244.1 ESA00268.1 - 0.11 12.0 0.1 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type HeLo PF14479.1 ESA00270.1 - 0.032 13.9 0.1 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation Peptidase_M27 PF01742.12 ESA00271.1 - 0.023 13.5 0.3 0.027 13.3 0.2 1.1 1 0 0 1 1 1 0 Clostridial neurotoxin zinc protease Aida_N PF08910.5 ESA00271.1 - 0.053 13.7 0.3 0.48 10.6 0.1 2.0 1 1 1 2 2 2 0 Aida N-terminus LRR_4 PF12799.2 ESA00273.1 - 7.6e-09 35.0 1.3 0.00022 20.7 0.1 4.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA00273.1 - 1.9e-06 27.3 12.8 0.31 11.2 0.0 6.4 6 1 1 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.1 ESA00273.1 - 3.9e-06 26.5 10.0 0.0001 21.9 0.8 4.7 2 1 3 5 5 5 3 Leucine rich repeat F-box-like PF12937.2 ESA00273.1 - 4.6e-06 26.2 1.0 1.3e-05 24.8 0.7 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.28 ESA00273.1 - 0.001 18.7 11.7 1.4 9.2 0.1 5.9 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA00273.1 - 0.0025 17.7 8.0 10 6.8 0.0 5.8 6 0 0 6 6 6 2 Leucine rich repeat TLD PF07534.11 ESA00274.1 - 3.8e-14 52.8 0.3 6.5e-14 52.0 0.2 1.4 1 0 0 1 1 1 1 TLD Sel1 PF08238.7 ESA00276.1 - 6.9e-93 303.0 31.0 6.3e-13 48.9 0.1 10.0 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA00276.1 - 2.8e-08 33.6 14.5 6.5 7.4 0.1 9.2 9 1 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00276.1 - 0.0044 17.1 17.0 2.7 8.3 0.0 8.4 10 0 0 10 10 10 1 Tetratricopeptide repeat DUF3731 PF12531.3 ESA00276.1 - 0.072 12.6 0.0 16 4.8 0.0 3.4 3 1 0 3 3 3 0 DNA-K related protein MIT PF04212.13 ESA00276.1 - 1.9 8.4 22.7 0.98 9.3 0.2 6.6 6 4 1 7 7 7 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA00276.1 - 1.9 8.4 24.1 16 5.4 0.2 7.1 3 3 4 7 7 7 0 Tetratricopeptide repeat LRR_4 PF12799.2 ESA00279.1 - 0.059 13.0 11.2 6.4 6.5 0.2 4.6 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA00279.1 - 2.1 8.1 9.0 1.3 8.8 0.2 3.7 3 2 0 3 3 3 0 Leucine rich repeat WD40 PF00400.27 ESA00280.1 - 4.5e-31 105.5 1.9 7.5e-08 31.9 0.0 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 ESA00280.1 - 4.4e-29 100.1 0.4 9.1e-29 99.1 0.3 1.6 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 ESA00280.1 - 5.7e-07 29.4 0.0 8.3e-06 25.6 0.0 2.5 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Peptidase_M28 PF04389.12 ESA00281.1 - 5.8e-36 123.9 0.0 4.6e-35 120.9 0.0 2.2 2 1 0 2 2 2 1 Peptidase family M28 Nicastrin PF05450.10 ESA00281.1 - 0.00048 19.4 0.0 0.00089 18.5 0.0 1.4 1 0 0 1 1 1 1 Nicastrin MadM PF03818.8 ESA00281.1 - 0.078 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit RhoGAP PF00620.22 ESA00282.1 - 2.9e-40 137.3 0.0 6.4e-40 136.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Vps54 PF07928.7 ESA00282.1 - 0.051 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Vps54-like protein Imm16 PF15565.1 ESA00283.1 - 0.098 12.5 0.8 0.22 11.3 0.2 1.8 1 1 1 2 2 2 0 Immunity protein 16 BNIP2 PF12496.3 ESA00283.1 - 0.15 12.1 2.4 0.25 11.5 1.6 1.4 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF3753 PF12575.3 ESA00283.1 - 8.7 6.2 6.5 26 4.6 4.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3753) Arch_ATPase PF01637.13 ESA00284.1 - 0.094 12.4 0.2 0.14 11.8 0.1 1.3 1 1 0 1 1 1 0 Archaeal ATPase Uma2 PF05685.7 ESA00285.1 - 7.8e-07 28.5 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease Asp_protease_2 PF13650.1 ESA00286.1 - 0.014 15.8 0.0 0.036 14.5 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.15 ESA00286.1 - 0.059 13.2 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease zf-C2H2 PF00096.21 ESA00287.1 - 1.3e-12 47.2 28.9 5.8e-05 23.2 2.1 3.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA00287.1 - 1.3e-12 47.3 28.8 4.5e-09 36.1 2.4 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA00287.1 - 5.3e-09 35.7 28.1 0.0032 17.7 2.1 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA00287.1 - 0.00059 19.6 12.7 0.025 14.4 0.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 ESA00287.1 - 0.0011 18.5 0.8 0.0011 18.5 0.6 3.4 4 0 0 4 4 3 1 zinc-finger of a C2HC-type C1_4 PF07975.7 ESA00287.1 - 0.01 15.8 13.5 0.026 14.5 3.5 2.2 1 1 1 2 2 2 0 TFIIH C1-like domain zf-met PF12874.2 ESA00287.1 - 0.011 15.8 20.1 0.021 15.0 1.5 3.3 3 1 0 3 3 3 0 Zinc-finger of C2H2 type GAGA PF09237.6 ESA00287.1 - 0.017 14.6 3.6 0.017 14.6 2.5 2.1 1 1 0 1 1 1 0 GAGA factor RRN7 PF11781.3 ESA00287.1 - 0.023 14.1 2.9 7.2 6.2 0.0 3.1 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-met2 PF12907.2 ESA00287.1 - 0.062 13.2 12.9 0.79 9.7 1.2 3.3 3 0 0 3 3 3 0 Zinc-binding Zn_Tnp_IS1595 PF12760.2 ESA00287.1 - 0.082 12.7 12.7 0.28 11.0 1.7 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-FCS PF06467.9 ESA00287.1 - 0.1 12.2 9.0 0.89 9.2 0.3 3.1 1 1 2 3 3 3 0 MYM-type Zinc finger with FCS sequence motif Baculo_IE-1 PF05290.6 ESA00287.1 - 0.15 11.7 4.0 10 5.8 0.0 2.8 1 1 2 3 3 3 0 Baculovirus immediate-early protein (IE-0) DUF164 PF02591.10 ESA00287.1 - 0.23 11.3 3.7 1.8 8.4 0.1 2.3 2 1 0 2 2 2 0 Putative zinc ribbon domain Zn-ribbon_8 PF09723.5 ESA00287.1 - 0.28 11.1 9.5 3.8 7.5 0.5 3.0 1 1 2 3 3 3 0 Zinc ribbon domain zf-BED PF02892.10 ESA00287.1 - 0.33 10.7 17.3 0.86 9.4 0.2 3.2 1 1 2 3 3 3 0 BED zinc finger zf-CHY PF05495.7 ESA00287.1 - 0.34 11.1 13.5 1.4 9.1 9.4 1.9 1 1 0 1 1 1 0 CHY zinc finger zf-C4 PF00105.13 ESA00287.1 - 0.38 11.0 9.1 19 5.5 6.3 2.7 1 1 0 1 1 1 0 Zinc finger, C4 type (two domains) Zn_ribbon_recom PF13408.1 ESA00287.1 - 0.49 10.6 4.7 0.53 10.5 1.1 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zinc-ribbons_6 PF07191.7 ESA00287.1 - 0.49 10.2 8.0 3.8 7.3 0.3 2.9 1 1 1 2 2 2 0 zinc-ribbons PHD PF00628.24 ESA00287.1 - 1.2 8.8 10.0 7.1 6.4 6.9 2.2 1 1 0 1 1 1 0 PHD-finger DNA_RNApol_7kD PF03604.8 ESA00287.1 - 1.5 8.3 4.8 10 5.6 0.1 2.8 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit LIM PF00412.17 ESA00287.1 - 1.5 8.9 12.1 1.4 9.0 3.4 2.2 1 1 1 2 2 2 0 LIM domain zf-DNL PF05180.7 ESA00287.1 - 1.9 8.2 8.3 0.61 9.8 1.6 2.1 2 0 0 2 2 2 0 DNL zinc finger DUF2256 PF10013.4 ESA00287.1 - 1.9 8.3 7.1 6 6.7 0.3 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Ribosomal_L37ae PF01780.14 ESA00287.1 - 2.7 7.9 4.6 4.4 7.2 2.4 2.0 1 1 0 1 1 1 0 Ribosomal L37ae protein family HypA PF01155.14 ESA00287.1 - 2.7 7.6 5.1 13 5.5 3.6 1.9 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-Sec23_Sec24 PF04810.10 ESA00287.1 - 2.8 7.5 6.2 16 5.1 0.0 3.0 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-C2H2_jaz PF12171.3 ESA00287.1 - 3.5 7.9 20.5 3 8.0 1.4 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 ESA00287.1 - 5.5 7.1 16.1 7.1 6.8 0.4 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-RING_5 PF14634.1 ESA00287.1 - 5.8 6.7 12.5 24 4.7 8.7 2.2 1 1 0 1 1 1 0 zinc-RING finger domain Elf1 PF05129.8 ESA00287.1 - 5.8 6.6 8.7 6.7 6.4 3.7 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-AN1 PF01428.11 ESA00287.1 - 8 6.4 21.8 3.7 7.4 0.2 3.1 1 1 2 3 3 3 0 AN1-like Zinc finger Clathrin_bdg PF15045.1 ESA00288.1 - 0.00071 19.0 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking Cullin PF00888.17 ESA00289.1 - 1.2e-201 671.2 14.8 1.7e-201 670.7 10.3 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESA00289.1 - 4.7e-29 100.0 3.0 1.2e-28 98.6 2.1 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain PNPase PF03726.9 ESA00291.1 - 0.046 14.0 0.9 0.21 11.8 0.0 2.3 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain SR-25 PF10500.4 ESA00291.1 - 3.8 6.9 11.4 6.7 6.1 7.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Transposase_21 PF02992.9 ESA00292.1 - 0.0063 15.6 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Transposase family tnp2 DUF3039 PF11238.3 ESA00292.1 - 0.09 12.2 0.0 0.24 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) ubiquitin PF00240.18 ESA00293.1 - 0.028 13.8 0.7 0.41 10.0 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin family TSC22 PF01166.13 ESA00293.1 - 0.14 12.1 0.2 1.8 8.5 0.1 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family TraH PF06122.6 ESA00295.1 - 0.0097 14.7 0.5 0.011 14.5 0.3 1.0 1 0 0 1 1 1 1 Conjugative relaxosome accessory transposon protein Sigma70_r4_2 PF08281.7 ESA00295.1 - 0.019 14.4 0.3 0.061 12.7 0.1 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 GerE PF00196.14 ESA00295.1 - 0.062 12.6 0.4 0.13 11.5 0.3 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family PaaSYMP PF14738.1 ESA00296.1 - 4.4 7.0 14.6 0.11 12.1 4.8 2.3 2 0 0 2 2 2 0 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 BTB_2 PF02214.17 ESA00297.1 - 1.5e-19 69.9 0.1 2.9e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TPR_MLP1_2 PF07926.7 ESA00298.1 - 0.0071 16.0 21.4 0.1 12.3 1.0 2.1 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.3 ESA00298.1 - 0.0096 15.7 7.8 0.0096 15.7 5.4 2.9 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding Myosin_tail_1 PF01576.14 ESA00298.1 - 0.011 13.4 18.0 0.013 13.2 12.5 1.2 1 0 0 1 1 1 0 Myosin tail Macoilin PF09726.4 ESA00298.1 - 0.014 13.7 19.9 0.015 13.6 13.8 1.0 1 0 0 1 1 1 0 Transmembrane protein Exonuc_VII_S PF02609.11 ESA00298.1 - 0.028 14.1 1.8 0.028 14.1 1.3 2.8 2 1 2 4 4 4 0 Exonuclease VII small subunit Striatin PF08232.7 ESA00298.1 - 0.048 13.9 16.9 0.85 9.9 11.7 2.1 1 1 0 1 1 1 0 Striatin family Sec34 PF04136.10 ESA00298.1 - 0.066 12.9 7.1 0.087 12.5 5.0 1.2 1 0 0 1 1 1 0 Sec34-like family PMEI PF04043.10 ESA00298.1 - 0.066 13.1 1.0 0.076 12.9 0.7 1.2 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor WEMBL PF05701.6 ESA00298.1 - 0.067 11.6 19.0 0.081 11.3 13.2 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light TACC PF05010.9 ESA00298.1 - 0.078 12.7 15.5 0.11 12.2 10.8 1.3 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) FlaC_arch PF05377.6 ESA00298.1 - 0.096 12.5 6.5 0.45 10.4 1.4 2.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Rootletin PF15035.1 ESA00298.1 - 0.15 12.0 18.1 0.18 11.8 12.5 1.0 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion APG6 PF04111.7 ESA00298.1 - 0.18 10.8 17.9 0.21 10.6 12.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Reo_sigmaC PF04582.7 ESA00298.1 - 0.21 10.7 2.3 0.23 10.6 1.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CALCOCO1 PF07888.6 ESA00298.1 - 0.23 9.7 17.8 0.27 9.4 12.3 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.4 ESA00298.1 - 0.24 10.2 16.1 0.29 10.0 10.6 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HlyD PF00529.15 ESA00298.1 - 0.37 10.0 11.5 0.45 9.7 8.0 1.2 1 0 0 1 1 1 0 HlyD family secretion protein GldM_N PF12081.3 ESA00298.1 - 0.45 10.0 10.1 0.53 9.7 7.0 1.1 1 0 0 1 1 1 0 GldM N-terminal domain Cortex-I_coil PF09304.5 ESA00298.1 - 0.49 10.4 19.6 0.47 10.5 1.3 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil ADIP PF11559.3 ESA00298.1 - 0.56 10.1 20.6 0.18 11.7 8.6 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding XPG_I_2 PF12813.2 ESA00298.1 - 0.59 9.5 4.8 1.4 8.3 3.3 1.6 1 1 0 1 1 1 0 XPG domain containing TMF_TATA_bd PF12325.3 ESA00298.1 - 0.72 9.5 20.2 0.067 12.9 1.3 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESA00298.1 - 0.77 9.3 19.9 1.3 8.5 13.8 1.5 1 1 0 1 1 1 0 IncA protein DUF4200 PF13863.1 ESA00298.1 - 0.83 9.6 22.6 0.069 13.1 7.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Lectin_N PF03954.9 ESA00298.1 - 0.92 8.9 6.5 0.84 9.0 3.9 1.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Laminin_II PF06009.7 ESA00298.1 - 0.99 9.1 15.2 0.28 10.9 7.0 1.9 1 1 1 2 2 2 0 Laminin Domain II HlyD_2 PF12700.2 ESA00298.1 - 1.2 8.2 10.7 1.5 7.9 7.4 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Fmp27_WPPW PF10359.4 ESA00298.1 - 1.3 7.3 10.7 1.5 7.1 7.4 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF745 PF05335.8 ESA00298.1 - 1.5 8.3 15.3 3.3 7.1 10.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Phage_GP20 PF06810.6 ESA00298.1 - 1.7 8.0 16.2 1.7 8.0 10.6 1.5 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF2968 PF11180.3 ESA00298.1 - 2.2 7.6 15.2 0.58 9.5 8.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) Seryl_tRNA_N PF02403.17 ESA00298.1 - 2.6 8.0 16.2 0.28 11.2 6.9 2.1 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DASH_Hsk3 PF08227.6 ESA00298.1 - 3.8 7.7 7.7 3.4 7.9 0.3 3.4 4 1 0 4 4 2 0 DASH complex subunit Hsk3 like DUF4600 PF15372.1 ESA00298.1 - 3.9 7.7 16.2 7 6.8 11.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) SLX9 PF15341.1 ESA00298.1 - 5.1 7.5 15.0 7.9 6.9 10.3 1.5 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 Rho_Binding PF08912.6 ESA00298.1 - 5.3 7.4 17.1 0.47 10.7 7.9 2.1 2 1 0 2 2 2 0 Rho Binding DUF3416 PF11896.3 ESA00298.1 - 5.8 6.8 8.5 3.3 7.6 4.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3416) CorA PF01544.13 ESA00298.1 - 6.5 5.7 8.1 7.5 5.4 5.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.5 ESA00298.1 - 8.8 6.4 14.6 1.3 9.0 2.9 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4337 PF14235.1 ESA00298.1 - 8.9 6.1 13.1 16 5.2 9.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) SlyX PF04102.7 ESA00299.1 - 0.00063 20.0 1.3 0.00063 20.0 0.9 2.4 1 1 1 2 2 2 1 SlyX IncA PF04156.9 ESA00299.1 - 0.048 13.2 13.0 0.056 13.0 9.0 1.1 1 0 0 1 1 1 0 IncA protein CtIP_N PF10482.4 ESA00299.1 - 0.049 13.4 10.1 0.62 9.8 7.0 2.2 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain TMF_DNA_bd PF12329.3 ESA00299.1 - 0.057 13.2 2.9 0.057 13.2 2.0 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 ESA00299.1 - 0.074 11.4 8.7 0.083 11.3 6.0 1.0 1 0 0 1 1 1 0 AAA domain DUF2501 PF10696.4 ESA00299.1 - 0.098 12.6 0.6 0.16 11.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2501) Reo_sigmaC PF04582.7 ESA00299.1 - 0.1 11.7 0.3 0.12 11.5 0.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ADIP PF11559.3 ESA00299.1 - 0.12 12.2 11.7 0.16 11.9 8.1 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding V-ATPase_C PF03223.10 ESA00299.1 - 0.12 11.2 2.8 0.2 10.5 1.9 1.5 1 1 0 1 1 1 0 V-ATPase subunit C Atg14 PF10186.4 ESA00299.1 - 0.14 11.0 10.7 0.16 10.8 7.4 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF641 PF04859.7 ESA00299.1 - 0.34 10.6 10.0 0.83 9.4 1.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) BLOC1_2 PF10046.4 ESA00299.1 - 0.49 10.5 9.5 4 7.6 5.4 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 V_ATPase_I PF01496.14 ESA00299.1 - 0.94 7.2 7.7 1.1 7.0 5.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESA00299.1 - 1 8.3 14.1 1.1 8.1 9.8 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.7 ESA00299.1 - 1.3 8.8 5.1 0.57 9.9 1.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Bap31 PF05529.7 ESA00299.1 - 1.6 8.1 5.8 2.1 7.7 4.0 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Fib_alpha PF08702.5 ESA00299.1 - 1.7 8.7 7.5 2.3 8.3 5.2 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Nup54 PF13874.1 ESA00299.1 - 2.6 7.6 7.2 3.3 7.3 5.0 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF724 PF05266.9 ESA00299.1 - 2.6 7.6 9.5 4.2 6.9 6.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Kinesin PF00225.18 ESA00300.1 - 1e-27 96.7 0.0 1.1e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Pkinase PF00069.20 ESA00301.1 - 8.9e-12 44.7 1.4 2e-11 43.5 1.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00301.1 - 3.4e-05 23.0 0.3 9.9e-05 21.5 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA00301.1 - 0.0011 18.4 0.0 0.0023 17.3 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ESA00301.1 - 0.0024 17.4 1.1 0.0065 16.0 0.6 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 ESA00301.1 - 0.0049 16.6 0.0 0.021 14.5 0.1 1.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA00301.1 - 0.083 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 ESA00301.1 - 0.12 11.4 0.2 0.25 10.3 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IncA PF04156.9 ESA00302.1 - 1.4 8.4 8.6 4.6 6.7 5.9 1.9 1 0 0 1 1 1 0 IncA protein Dynein_IC2 PF11540.3 ESA00303.1 - 0.0029 16.9 0.0 0.0071 15.6 0.0 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 DLH PF01738.13 ESA00304.1 - 1e-21 77.2 0.0 1.3e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 ESA00304.1 - 3.3e-05 23.6 0.0 4.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA00304.1 - 0.022 14.3 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF4391 PF14335.1 ESA00305.1 - 0.02 14.2 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) DUF2423 PF10338.4 ESA00305.1 - 0.1 12.5 1.1 0.18 11.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) zf-C2H2_jaz PF12171.3 ESA00306.1 - 1.8e-05 24.7 0.1 3.5e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESA00306.1 - 0.00011 22.3 0.7 0.00035 20.7 0.5 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA00306.1 - 0.0017 18.5 0.4 0.005 17.0 0.3 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA00306.1 - 0.0021 17.8 0.2 0.005 16.7 0.2 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger DUF1091 PF06477.8 ESA00306.1 - 0.021 15.2 1.0 0.26 11.7 0.1 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1091) Peptidase_C36 PF05415.6 ESA00306.1 - 0.085 12.7 0.0 0.58 10.0 0.0 2.1 2 0 0 2 2 2 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase zf-C2H2_2 PF12756.2 ESA00306.1 - 3.7 7.7 5.5 1.5 8.9 0.1 2.6 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Steroid_dh PF02544.11 ESA00307.1 - 0.004 16.9 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ricin_B_lectin PF00652.17 ESA00307.1 - 0.0055 16.7 0.1 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF4379 PF14311.1 ESA00307.1 - 0.028 14.2 2.1 0.063 13.1 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) Defensin_3 PF08131.6 ESA00307.1 - 0.4 10.7 4.1 11 6.1 0.2 2.6 2 0 0 2 2 2 0 Defensin-like peptide family Pox_A32 PF04665.7 ESA00308.1 - 4.3e-10 39.2 0.2 4.1e-06 26.2 0.0 2.1 1 1 1 2 2 2 2 Poxvirus A32 protein Zot PF05707.7 ESA00308.1 - 0.013 15.0 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) FtsK_SpoIIIE PF01580.13 ESA00308.1 - 0.041 13.3 0.0 0.074 12.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Steroid_dh PF02544.11 ESA00308.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1371 PF07115.6 ESA00309.1 - 0.42 10.8 4.8 0.54 10.4 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1371) DUF3919 PF13057.1 ESA00310.1 - 0.026 13.9 0.0 0.056 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) Pox_E6 PF04656.7 ESA00313.1 - 0.022 13.0 0.8 0.029 12.5 0.5 1.1 1 0 0 1 1 1 0 Pox virus E6 protein RVT_1 PF00078.22 ESA00314.1 - 4.7e-05 22.8 0.1 7.7e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BTB_2 PF02214.17 ESA00315.1 - 0.0048 17.0 0.3 0.0058 16.8 0.2 1.0 1 0 0 1 1 1 1 BTB/POZ domain Glyco_tran_28_C PF04101.11 ESA00316.1 - 7.3e-30 103.8 0.0 8.4e-30 103.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA00316.1 - 3.9e-06 26.2 0.0 4.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 1 Myb_DNA-binding PF00249.26 ESA00317.1 - 2.1e-16 59.7 0.2 2.1e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA00317.1 - 2.6e-12 46.6 0.3 8.9e-08 32.1 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Nop16 PF09420.5 ESA00317.1 - 0.0065 16.5 1.8 0.0067 16.5 0.4 1.6 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 Homeobox PF00046.24 ESA00318.1 - 5.8e-21 73.8 2.8 6.2e-21 73.7 2.0 1.0 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 ESA00318.1 - 0.00097 18.7 0.1 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain Pkinase PF00069.20 ESA00319.1 - 1e-32 113.3 0.2 1.1e-32 113.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00319.1 - 1.5e-32 112.6 0.1 1.7e-32 112.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA00319.1 - 0.00026 20.7 0.1 0.00035 20.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA00319.1 - 0.0013 18.0 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 RIO1 family PI3_PI4_kinase PF00454.22 ESA00319.1 - 0.091 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase DUF4301 PF14134.1 ESA00320.1 - 0.033 12.7 0.3 0.034 12.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) Rax2 PF12768.2 ESA00321.1 - 0.0001 21.6 0.1 0.00012 21.4 0.0 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity TMEM154 PF15102.1 ESA00321.1 - 0.0072 16.0 0.2 0.0093 15.6 0.2 1.1 1 0 0 1 1 1 1 TMEM154 protein family Auxin_repressed PF05564.7 ESA00321.1 - 0.013 16.1 0.3 0.019 15.5 0.2 1.2 1 0 0 1 1 1 0 Dormancy/auxin associated protein TMEM51 PF15345.1 ESA00321.1 - 0.021 14.5 0.1 0.025 14.3 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Herpes_UL45 PF05473.7 ESA00321.1 - 0.026 13.9 0.0 0.03 13.7 0.0 1.1 1 0 0 1 1 1 0 UL45 protein SKG6 PF08693.5 ESA00321.1 - 0.048 12.9 2.3 0.16 11.3 1.6 2.0 1 1 0 1 1 1 0 Transmembrane alpha-helix domain Plasmodium_Vir PF05795.6 ESA00321.1 - 0.072 12.2 0.6 0.085 12.0 0.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4293 PF14126.1 ESA00321.1 - 0.1 12.5 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) DUF1049 PF06305.6 ESA00321.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) RseC_MucC PF04246.7 ESA00321.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Adeno_E3_CR2 PF02439.10 ESA00321.1 - 0.49 9.9 2.9 1.3 8.6 2.0 1.7 1 1 0 1 1 1 0 Adenovirus E3 region protein CR2 AKAP7_NLS PF10469.4 ESA00323.1 - 1.1e-44 152.6 0.1 1.7e-44 152.0 0.0 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.24 ESA00323.1 - 1.4e-15 56.6 1.6 3.8e-15 55.2 1.1 1.8 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ESA00323.1 - 1.2e-10 40.7 0.9 4.2e-10 39.0 0.6 2.0 1 0 0 1 1 1 1 KH domain 2_5_RNA_ligase2 PF13563.1 ESA00323.1 - 1.1e-05 25.1 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily HVSL PF09749.4 ESA00323.1 - 0.0032 16.5 0.3 0.012 14.6 0.1 1.8 2 0 0 2 2 2 1 Uncharacterised conserved protein Glyco_tran_28_C PF04101.11 ESA00323.1 - 0.085 12.5 0.2 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain Ribosomal_S2 PF00318.15 ESA00325.1 - 6.9e-54 182.2 0.2 5e-53 179.4 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein S2 KH_2 PF07650.12 ESA00328.1 - 0.19 11.2 2.2 1.4 8.5 0.8 2.4 2 0 0 2 2 2 0 KH domain ABC_membrane PF00664.18 ESA00329.1 - 2.3e-52 178.1 45.8 7.4e-27 94.4 14.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA00329.1 - 1.5e-44 151.5 0.0 2.7e-32 111.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 ESA00329.1 - 6.8e-10 39.3 7.0 1.8e-07 31.3 0.4 4.0 3 1 0 3 3 3 2 AAA domain SMC_N PF02463.14 ESA00329.1 - 8.1e-08 31.7 0.7 1.3e-05 24.6 1.2 2.8 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain T2SE PF00437.15 ESA00329.1 - 0.00022 20.2 0.0 0.00044 19.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 ESA00329.1 - 0.00035 20.7 2.9 0.048 13.8 0.5 4.2 3 2 0 3 3 3 1 AAA domain AAA_25 PF13481.1 ESA00329.1 - 0.0011 18.3 0.0 0.44 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 ESA00329.1 - 0.0021 17.8 0.0 0.0068 16.2 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Miro PF08477.8 ESA00329.1 - 0.003 18.0 0.0 0.33 11.4 0.0 3.0 2 0 0 2 2 2 1 Miro-like protein AAA_10 PF12846.2 ESA00329.1 - 0.0051 16.2 0.1 0.79 9.1 0.0 3.1 3 0 0 3 3 3 1 AAA-like domain AAA_29 PF13555.1 ESA00329.1 - 0.0053 16.2 0.2 0.32 10.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_14 PF13173.1 ESA00329.1 - 0.011 15.6 0.1 3.6 7.5 0.0 3.1 2 1 1 3 3 3 0 AAA domain AAA_18 PF13238.1 ESA00329.1 - 0.012 15.8 0.5 0.012 15.8 0.3 3.2 3 1 0 3 3 2 0 AAA domain MobB PF03205.9 ESA00329.1 - 0.018 14.7 0.1 0.25 11.0 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 ESA00329.1 - 0.021 14.3 0.0 1.6 8.1 0.0 2.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF87 PF01935.12 ESA00329.1 - 0.031 14.1 0.2 0.089 12.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 ESA00329.1 - 0.035 14.0 0.1 0.24 11.3 0.0 2.5 3 0 0 3 3 2 0 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA00329.1 - 0.058 13.3 0.1 0.6 10.0 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain Peptidase_M76 PF09768.4 ESA00330.1 - 2.9e-68 228.7 9.1 3.8e-68 228.3 6.3 1.1 1 0 0 1 1 1 1 Peptidase M76 family Ribosomal_S8e PF01201.17 ESA00330.1 - 0.037 14.1 0.0 0.045 13.8 0.0 1.3 1 1 0 1 1 1 0 Ribosomal protein S8e zf-CW PF07496.10 ESA00330.1 - 0.045 13.4 0.4 0.045 13.4 0.3 3.0 4 0 0 4 4 4 0 CW-type Zinc Finger zf-CSL PF05207.8 ESA00331.1 - 8.1e-17 60.4 0.7 1.5e-16 59.6 0.5 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.26 ESA00331.1 - 3.6e-15 55.4 1.5 7.8e-15 54.3 1.1 1.6 1 1 0 1 1 1 1 DnaJ domain Rho_Binding PF08912.6 ESA00331.1 - 1.2 9.4 5.2 5.4 7.3 0.4 2.6 1 1 1 2 2 2 0 Rho Binding DUF4238 PF14022.1 ESA00332.1 - 1.1e-20 74.0 5.1 1.9e-20 73.2 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4238) EF-hand_9 PF14658.1 ESA00332.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain BTB PF00651.26 ESA00340.1 - 1.3e-10 41.2 0.1 6.5e-10 38.9 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain DNA_pol_B PF00136.16 ESA00341.1 - 6.7e-20 71.3 0.4 1.6e-18 66.7 0.3 2.4 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESA00342.1 - 7.2e-15 54.6 0.0 7.7e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF4606 PF15379.1 ESA00343.1 - 0.049 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) Pkinase PF00069.20 ESA00344.1 - 4e-08 32.7 0.0 4.8e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00344.1 - 1.8e-05 23.9 0.0 2.1e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase BTB PF00651.26 ESA00346.1 - 6.1e-15 55.1 0.1 7.1e-15 54.9 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain FAD_binding_3 PF01494.14 ESA00348.1 - 0.0031 16.6 0.0 0.0033 16.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain BTB PF00651.26 ESA00349.1 - 2.6e-17 62.8 0.3 4.9e-17 61.9 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA00349.1 - 0.054 13.3 1.5 0.096 12.5 0.1 2.2 3 0 0 3 3 3 0 BTB And C-terminal Kelch Pro_isomerase PF00160.16 ESA00350.1 - 6.5e-48 162.8 0.3 7.4e-48 162.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_6 PF14259.1 ESA00352.1 - 1.8e-39 133.5 0.5 7.1e-11 41.9 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA00352.1 - 1.3e-33 114.4 1.3 2.4e-11 43.0 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA00352.1 - 1.5e-20 72.7 2.2 2.7e-06 27.1 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA00352.1 - 2.3e-08 33.8 0.7 0.00042 20.1 0.2 2.9 3 0 0 3 3 3 2 RNA binding motif NID PF07292.8 ESA00352.1 - 1.5e-06 28.1 0.0 0.0038 17.2 0.0 2.6 2 0 0 2 2 2 2 Nmi/IFP 35 domain (NID) DUF1866 PF08952.6 ESA00352.1 - 2.1e-06 27.3 0.1 0.22 11.0 0.0 4.1 2 2 2 4 4 4 2 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.1 ESA00352.1 - 0.013 15.2 0.0 3.2 7.5 0.0 3.5 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif tRNA-synt_2 PF00152.15 ESA00353.1 - 1.8e-77 260.3 0.3 1.5e-75 254.1 0.0 2.0 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESA00353.1 - 5.9e-08 32.4 0.0 1.3e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF1565 PF07602.6 ESA00353.1 - 0.02 14.0 0.1 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) tRNA_anti-like PF12869.2 ESA00353.1 - 0.025 14.0 0.0 0.061 12.7 0.0 1.6 1 0 0 1 1 1 0 tRNA_anti-like tRNA-synt_2b PF00587.20 ESA00353.1 - 0.043 13.3 0.2 0.28 10.7 0.0 2.3 3 0 0 3 3 3 0 tRNA synthetase class II core domain (G, H, P, S and T) Glycogen_syn PF05693.8 ESA00353.1 - 0.048 11.9 0.1 0.075 11.2 0.1 1.2 1 0 0 1 1 1 0 Glycogen synthase FemAB PF02388.11 ESA00353.1 - 0.16 10.6 7.7 0.28 9.8 5.3 1.3 1 0 0 1 1 1 0 FemAB family zf-DNL PF05180.7 ESA00354.1 - 1.6e-22 78.9 1.5 2.5e-22 78.3 0.3 1.7 2 0 0 2 2 2 1 DNL zinc finger CoaE PF01121.15 ESA00355.1 - 1.3e-59 200.6 0.0 1.5e-59 200.4 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 ESA00355.1 - 0.0018 19.0 0.1 0.0033 18.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA00355.1 - 0.0029 17.9 0.2 0.0069 16.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain Aminotran_5 PF00266.14 ESA00356.1 - 1.5e-46 158.8 0.0 1.9e-46 158.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Disaggr_assoc PF08480.5 ESA00356.1 - 0.0011 18.4 0.2 0.0022 17.4 0.1 1.4 1 0 0 1 1 1 1 Disaggregatase related Cyt-b5 PF00173.23 ESA00357.1 - 1.1e-10 41.1 0.3 1.6e-10 40.6 0.2 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NQR2_RnfD_RnfE PF03116.10 ESA00357.1 - 0.00061 19.0 0.0 0.00099 18.3 0.0 1.3 1 0 0 1 1 1 1 NQR2, RnfD, RnfE family Nup188 PF10487.4 ESA00357.1 - 0.12 10.2 0.0 0.15 9.9 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 Peptidase_C48 PF02902.14 ESA00358.1 - 0.00078 19.1 0.0 0.00078 19.1 0.0 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ERG4_ERG24 PF01222.12 ESA00359.1 - 4.8e-147 489.9 12.1 5.4e-147 489.8 8.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 ESA00359.1 - 0.018 14.3 0.4 0.042 13.1 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) TypeIII_RM_meth PF12564.3 ESA00359.1 - 0.02 14.8 0.5 0.048 13.6 0.0 1.8 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit TLD PF07534.11 ESA00360.1 - 0.0026 17.7 1.0 0.0049 16.8 0.6 1.5 1 1 0 1 1 1 1 TLD Pkinase_Tyr PF07714.12 ESA00365.1 - 4.2e-27 94.8 0.0 5.2e-27 94.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00365.1 - 3.8e-26 91.8 0.6 6.2e-26 91.1 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA00365.1 - 0.003 17.3 0.1 0.029 14.1 0.2 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Peptidase_S8 PF00082.17 ESA00368.1 - 4.3e-47 160.5 0.0 6e-47 160.1 0.0 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.17 ESA00368.1 - 3.7e-11 42.6 0.1 1e-10 41.2 0.1 1.8 1 0 0 1 1 1 1 PA domain DUF1034 PF06280.7 ESA00368.1 - 7.6e-09 35.9 0.3 2.1e-08 34.5 0.2 1.8 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Pkinase PF00069.20 ESA00369.1 - 4.4e-22 78.4 0.2 9.4e-22 77.3 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00369.1 - 4.1e-19 68.6 0.0 4.8e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00369.1 - 6.4e-05 22.0 0.0 7.2e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA00369.1 - 0.0035 17.1 0.4 0.011 15.4 0.3 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA00369.1 - 0.0076 15.6 0.2 0.0078 15.5 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA00369.1 - 0.015 14.3 0.1 0.015 14.3 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA00369.1 - 0.026 13.7 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF2591 PF10765.4 ESA00371.1 - 0.012 15.8 0.0 0.012 15.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) Exo_endo_phos PF03372.18 ESA00372.1 - 6e-13 49.2 0.1 1.2e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.17 ESA00372.1 - 5.7e-05 22.6 0.9 0.023 14.3 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA00372.1 - 6.1e-05 22.9 0.2 0.16 11.9 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA00372.1 - 0.0008 19.2 3.1 0.0015 18.3 2.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA00372.1 - 0.086 12.3 1.2 0.17 11.3 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle RNase_H PF00075.19 ESA00373.1 - 2.8e-11 43.8 0.8 7.1e-11 42.5 0.3 2.0 2 0 0 2 2 2 1 RNase H RVT_1 PF00078.22 ESA00373.1 - 1.1e-05 24.8 0.0 2.9e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Fmp27_GFWDK PF10347.4 ESA00374.1 - 7e-43 146.2 0.0 1.4e-42 145.2 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 ESA00374.1 - 1.4e-34 119.0 1.1 4.6e-34 117.4 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_WPPW PF10359.4 ESA00374.1 - 2.9e-32 111.7 2.8 6.8e-32 110.4 1.9 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.4 ESA00374.1 - 1.9e-12 47.5 0.0 1.9e-11 44.2 0.0 2.8 2 1 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Med15_fungi PF05397.7 ESA00374.1 - 0.053 13.4 1.5 0.18 11.7 0.3 2.2 2 0 0 2 2 2 0 Mediator complex subunit 15 GCS PF03074.11 ESA00376.1 - 0.015 14.3 0.1 0.016 14.2 0.1 1.0 1 0 0 1 1 1 0 Glutamate-cysteine ligase DUF2877 PF11392.3 ESA00376.1 - 0.079 13.1 0.1 0.1 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2877) Pkinase_Tyr PF07714.12 ESA00377.1 - 8.2e-37 126.6 0.0 2.6e-36 125.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00377.1 - 5.1e-36 124.1 0.0 6.7e-34 117.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA00377.1 - 0.00065 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESA00378.1 - 1.5e-20 73.4 0.0 1.9e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00378.1 - 2.9e-19 69.1 0.0 3.9e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA00379.1 - 2.7e-21 75.7 0.1 3.1e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00379.1 - 2.3e-20 72.8 0.1 2.7e-20 72.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA00379.1 - 0.0051 15.8 0.0 0.0059 15.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Ras PF00071.17 ESA00380.1 - 8.6e-49 165.0 0.0 9.9e-49 164.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA00380.1 - 1.4e-15 57.8 0.0 2.5e-15 57.0 0.0 1.4 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESA00380.1 - 1.6e-10 40.4 0.0 2.1e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 ESA00380.1 - 0.00014 22.0 0.1 0.00088 19.4 0.1 2.0 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 ESA00380.1 - 0.00061 18.9 0.0 0.00075 18.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pox_A32 PF04665.7 ESA00380.1 - 0.021 14.1 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 ESA00380.1 - 0.023 13.4 3.5 0.83 8.2 0.1 2.5 2 1 1 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.1 ESA00380.1 - 0.053 13.6 0.4 0.22 11.6 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA00380.1 - 0.071 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 ESA00380.1 - 0.11 12.1 0.1 0.23 11.1 0.1 1.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MARVEL PF01284.18 ESA00383.1 - 0.00017 21.4 6.9 0.00034 20.4 4.8 1.6 1 1 0 1 1 1 1 Membrane-associating domain Wzy_C PF04932.10 ESA00383.1 - 0.083 12.6 2.7 0.071 12.9 0.6 1.7 1 1 1 2 2 2 0 O-Antigen ligase COX15-CtaA PF02628.10 ESA00383.1 - 0.086 11.6 1.7 0.091 11.6 0.3 1.6 2 0 0 2 2 2 0 Cytochrome oxidase assembly protein Cytochrom_B_N PF00033.14 ESA00383.1 - 0.12 11.7 8.1 3.2 7.0 5.6 2.1 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF4381 PF14316.1 ESA00383.1 - 0.34 10.9 3.1 2.7 8.1 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) GP41 PF00517.12 ESA00383.1 - 0.51 9.8 1.9 0.49 9.9 0.6 1.5 1 1 0 1 1 1 0 Retroviral envelope protein zf-DHHC PF01529.15 ESA00383.1 - 0.58 9.5 7.4 0.057 12.8 2.1 1.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase O-antigen_lig PF13425.1 ESA00383.1 - 2.2 8.2 9.3 1.3 8.9 4.2 2.2 2 1 1 3 3 3 0 O-antigen ligase like membrane protein AmiS_UreI PF02293.10 ESA00385.1 - 2.5 7.7 7.0 0.12 12.0 0.5 1.8 1 1 1 2 2 2 0 AmiS/UreI family transporter Pkinase_Tyr PF07714.12 ESA00386.1 - 2.1e-51 174.5 0.0 3.1e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00386.1 - 5.8e-49 166.5 0.0 1.1e-48 165.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA00386.1 - 1.6e-18 66.7 2.1 2.7e-06 27.8 0.0 4.5 4 0 0 4 4 4 4 Sel1 repeat DUF2666 PF10869.3 ESA00386.1 - 0.01 15.8 2.9 3.7 7.5 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF2666) APH PF01636.18 ESA00386.1 - 0.017 14.8 0.1 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA00386.1 - 0.036 13.1 0.1 0.066 12.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family O-antigen_lig PF13425.1 ESA00387.1 - 0.38 10.7 6.2 0.18 11.7 2.6 1.7 1 1 1 2 2 2 0 O-antigen ligase like membrane protein DUF2975 PF11188.3 ESA00387.1 - 9.9 5.8 9.8 0.7 9.6 0.2 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF2975) LRRCT PF01463.19 ESA00388.1 - 0.14 12.5 0.2 35 5.0 0.0 2.6 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain Bromodomain PF00439.20 ESA00389.1 - 5.6e-17 61.4 0.4 6.1e-17 61.3 0.3 1.0 1 0 0 1 1 1 1 Bromodomain Pkinase PF00069.20 ESA00390.1 - 3.3e-44 151.0 0.1 4e-44 150.7 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00390.1 - 1.4e-38 132.4 0.0 1.8e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA00390.1 - 0.00053 19.3 0.5 0.002 17.4 0.3 1.9 1 1 1 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA00390.1 - 0.001 18.1 0.0 0.0074 15.2 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA00390.1 - 0.003 16.6 0.1 0.0044 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA00390.1 - 0.011 15.4 0.5 0.024 14.3 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3013 PF11217.3 ESA00390.1 - 0.017 14.8 0.5 0.37 10.4 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3013) WaaY PF06176.6 ESA00390.1 - 0.042 13.0 0.1 0.068 12.3 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kelch_3 PF13415.1 ESA00392.1 - 2.1e-15 56.4 5.7 0.00063 19.8 0.0 6.7 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA00392.1 - 2.1e-15 56.1 6.9 0.0034 17.5 0.1 6.2 5 1 1 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ESA00392.1 - 8.7e-14 51.1 4.8 0.015 15.2 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESA00392.1 - 1.2e-13 50.5 8.3 0.027 14.2 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA00392.1 - 6.4e-07 28.8 4.8 0.014 15.1 0.0 6.0 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.20 ESA00392.1 - 3.7e-06 26.3 12.3 0.15 11.6 0.1 5.7 6 0 0 6 6 6 3 Kelch motif SKG6 PF08693.5 ESA00392.1 - 0.0082 15.4 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.2 ESA00392.1 - 0.044 12.9 0.3 1.1 8.4 0.1 2.8 2 1 0 3 3 3 0 Cortical protein marker for cell polarity RecX PF02631.11 ESA00393.1 - 0.068 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 RecX family Sel1 PF08238.7 ESA00395.1 - 8e-33 112.1 4.6 7.5e-12 45.4 0.2 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ESA00395.1 - 7.7e-06 26.0 0.7 2.2 8.9 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.13 ESA00395.1 - 0.00087 19.1 3.8 0.028 14.2 0.2 2.5 1 1 1 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ESA00395.1 - 0.0026 17.4 0.6 7.6 6.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00395.1 - 0.0057 16.2 6.8 0.098 12.3 1.7 3.2 1 1 1 3 3 3 1 TPR repeat TPR_12 PF13424.1 ESA00395.1 - 0.01 15.7 6.4 1.3 9.0 1.2 3.5 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00395.1 - 0.063 13.6 0.4 27 5.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00395.1 - 0.55 10.2 13.5 4.9 7.3 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA00395.1 - 0.6 9.9 5.8 7.4 6.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA00395.1 - 2.4 7.9 16.7 13 5.6 0.1 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF1002 PF06207.6 ESA00396.1 - 0.085 12.1 5.4 0.079 12.2 3.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1002) TetR_C_8 PF14278.1 ESA00396.1 - 0.11 12.8 1.2 0.27 11.6 0.9 1.7 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region Pkinase_Tyr PF07714.12 ESA00397.1 - 5.3e-29 101.0 0.0 5.8e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00397.1 - 6.9e-29 100.7 0.1 7.6e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA00397.1 - 0.00027 20.0 0.0 0.00029 19.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA00397.1 - 0.0019 17.5 0.0 0.0022 17.3 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA00397.1 - 0.0053 15.7 0.0 0.0057 15.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 ESA00397.1 - 0.0078 15.4 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA00397.1 - 0.026 14.2 0.2 0.031 14.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family NAD_binding_8 PF13450.1 ESA00402.1 - 3.8e-05 23.6 0.0 8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA00402.1 - 0.00012 21.8 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA00402.1 - 0.00097 19.2 0.0 0.0018 18.3 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESA00402.1 - 0.054 12.4 0.0 0.078 11.8 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.12 ESA00402.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family DAO PF01266.19 ESA00402.1 - 0.12 11.2 0.0 0.3 9.9 0.0 1.6 1 1 1 2 2 2 0 FAD dependent oxidoreductase Myb_DNA-bind_6 PF13921.1 ESA00403.1 - 0.0011 19.0 0.2 0.0045 17.0 0.0 2.1 2 1 0 2 2 2 1 Myb-like DNA-binding domain DUF4485 PF14846.1 ESA00403.1 - 0.035 13.8 1.8 1.6 8.4 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4485) DsrD PF08679.6 ESA00403.1 - 0.064 13.2 0.7 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) Amidase PF01425.16 ESA00404.1 - 1.3e-104 350.5 0.0 1.6e-104 350.2 0.0 1.0 1 0 0 1 1 1 1 Amidase DDE_1 PF03184.14 ESA00406.1 - 2.2e-10 40.0 0.0 5e-10 38.8 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA00406.1 - 0.00024 20.8 0.1 0.00038 20.2 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain GAD-like PF08887.6 ESA00406.1 - 0.038 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 GAD-like domain CheR PF01739.13 ESA00406.1 - 0.088 12.0 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Pkinase PF00069.20 ESA00407.1 - 1e-19 70.7 0.0 1.2e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00407.1 - 1.6e-18 66.7 0.0 2.1e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RecO_N_2 PF13114.1 ESA00407.1 - 0.027 14.1 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 RecO N terminal Sec1 PF00995.18 ESA00408.1 - 1.1e-31 110.0 0.5 1.2e-31 109.9 0.4 1.0 1 0 0 1 1 1 1 Sec1 family zf-RING_2 PF13639.1 ESA00409.1 - 9.3e-21 73.3 22.8 3.8e-14 52.2 6.3 2.3 2 0 0 2 2 2 2 Ring finger domain zf-rbx1 PF12678.2 ESA00409.1 - 5.5e-13 48.8 18.9 4.7e-10 39.4 3.0 2.7 2 1 0 2 2 2 2 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA00409.1 - 3.4e-12 46.1 19.8 2.6e-09 36.9 5.2 2.7 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA00409.1 - 7.7e-12 44.6 19.3 2.3e-10 39.9 4.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA00409.1 - 4.1e-11 42.4 23.7 2.5e-08 33.5 6.4 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA00409.1 - 1.8e-09 37.0 25.5 3.8e-08 32.8 7.2 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA00409.1 - 1.3e-06 28.1 15.7 0.0042 16.8 0.5 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 ESA00409.1 - 0.00029 20.4 16.9 0.0015 18.2 5.0 3.3 2 1 1 3 3 3 2 RING-type zinc-finger Rad50_zn_hook PF04423.9 ESA00409.1 - 0.00093 18.6 2.1 0.016 14.6 0.2 2.6 2 0 0 2 2 2 1 Rad50 zinc hook motif Prok-RING_4 PF14447.1 ESA00409.1 - 0.0023 17.4 1.6 0.0023 17.4 1.1 3.5 3 1 1 4 4 4 1 Prokaryotic RING finger family 4 zf-Nse PF11789.3 ESA00409.1 - 0.0027 17.1 5.8 0.0027 17.1 4.0 2.5 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.3 ESA00409.1 - 0.0042 17.0 18.6 0.031 14.2 4.6 3.3 2 2 0 2 2 2 1 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 ESA00409.1 - 0.015 15.1 10.5 0.015 15.1 7.3 3.8 2 2 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 ESA00409.1 - 0.016 14.7 8.1 0.016 14.7 5.6 3.3 2 2 1 3 3 3 0 RING/Ubox like zinc-binding domain Baculo_RING PF05883.6 ESA00409.1 - 0.018 14.9 1.8 0.043 13.6 1.3 1.6 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain PHD PF00628.24 ESA00409.1 - 0.018 14.6 2.1 0.018 14.6 1.4 3.0 2 1 0 2 2 1 0 PHD-finger zf-RING_6 PF14835.1 ESA00409.1 - 0.12 12.1 0.3 0.12 12.1 0.2 3.4 4 0 0 4 4 4 0 zf-RING of BARD1-type protein DUF329 PF03884.9 ESA00409.1 - 0.18 11.3 7.3 11 5.6 0.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF329) zf-P11 PF03854.9 ESA00409.1 - 2.8 7.5 11.1 0.038 13.4 1.3 2.5 3 0 0 3 3 3 0 P-11 zinc finger MAPEG PF01124.13 ESA00410.1 - 5.7e-20 71.2 0.1 6.4e-20 71.0 0.1 1.0 1 0 0 1 1 1 1 MAPEG family DCP2 PF05026.8 ESA00411.1 - 6.1e-38 128.6 2.6 1.5e-37 127.3 1.8 1.7 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 ESA00411.1 - 8.2e-15 54.6 0.0 1.5e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Maelstrom PF13017.1 ESA00412.1 - 0.0059 16.1 1.5 0.0071 15.8 1.0 1.1 1 0 0 1 1 1 1 piRNA pathway germ-plasm component DBD_Tnp_Hermes PF10683.4 ESA00412.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain NYN PF01936.13 ESA00413.1 - 1.4e-08 35.1 0.0 1.9e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 NYN domain Herpes_UL6 PF01763.11 ESA00415.1 - 0.00014 20.2 1.5 0.00015 20.0 1.1 1.0 1 0 0 1 1 1 1 Herpesvirus UL6 like DUF4355 PF14265.1 ESA00415.1 - 0.00056 19.8 3.7 0.00074 19.4 2.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4355) TerB-C PF15615.1 ESA00415.1 - 0.002 18.3 1.3 0.0025 18.0 0.9 1.1 1 0 0 1 1 1 1 TerB-C domain G0-G1_switch_2 PF15103.1 ESA00415.1 - 0.0025 18.0 0.3 0.0046 17.1 0.2 1.4 1 0 0 1 1 1 1 G0/G1 switch protein 2 bZIP_1 PF00170.16 ESA00415.1 - 0.0042 17.0 3.0 0.008 16.1 2.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor TMF_TATA_bd PF12325.3 ESA00415.1 - 0.018 14.7 6.0 0.025 14.3 4.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF972 PF06156.8 ESA00415.1 - 0.023 15.0 3.5 0.03 14.6 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Fmp27_WPPW PF10359.4 ESA00415.1 - 0.025 12.9 0.6 0.024 13.0 0.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Bap31 PF05529.7 ESA00415.1 - 0.057 12.8 3.2 0.07 12.5 2.2 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like F-actin_cap_A PF01267.12 ESA00415.1 - 0.058 12.4 0.6 0.1 11.6 0.3 1.4 1 1 0 1 1 1 0 F-actin capping protein alpha subunit DUF904 PF06005.7 ESA00415.1 - 0.085 13.1 9.2 0.14 12.5 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DivIC PF04977.10 ESA00415.1 - 0.13 11.7 5.0 0.13 11.7 2.7 1.6 1 1 0 1 1 1 0 Septum formation initiator Ax_dynein_light PF10211.4 ESA00415.1 - 0.14 12.0 4.8 0.17 11.6 3.3 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain DUF244 PF03112.9 ESA00415.1 - 0.15 11.5 4.1 0.19 11.2 2.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF HAUS6_N PF14661.1 ESA00415.1 - 0.16 11.2 2.6 0.21 10.9 1.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF1910 PF08928.5 ESA00415.1 - 0.21 11.6 2.8 0.32 11.0 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) Spc24 PF08286.6 ESA00415.1 - 0.28 10.8 7.5 0.47 10.1 5.2 1.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4337 PF14235.1 ESA00415.1 - 0.36 10.6 2.3 0.43 10.4 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) TMF_DNA_bd PF12329.3 ESA00415.1 - 0.44 10.3 10.2 0.23 11.2 5.5 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 ESA00415.1 - 0.62 9.0 4.6 0.69 8.9 3.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Pkinase PF00069.20 ESA00416.1 - 3.9e-05 22.9 0.0 4.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00416.1 - 0.0088 15.1 0.0 0.0093 15.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00416.1 - 0.1 11.5 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Kinase-like Hint PF01079.15 ESA00417.1 - 1e-18 67.3 0.0 1.2e-08 34.4 0.0 2.3 1 1 1 2 2 2 2 Hint module Z1 PF10593.4 ESA00417.1 - 0.044 12.9 1.0 0.072 12.2 0.7 1.3 1 0 0 1 1 1 0 Z1 domain CALCOCO1 PF07888.6 ESA00417.1 - 0.092 11.0 7.0 0.12 10.6 4.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HET PF06985.6 ESA00417.1 - 0.12 12.5 1.0 0.23 11.6 0.7 1.5 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) AAA_23 PF13476.1 ESA00417.1 - 0.65 10.2 10.0 0.34 11.1 5.5 1.6 2 0 0 2 2 2 0 AAA domain HAUS6_N PF14661.1 ESA00417.1 - 2.9 7.1 12.5 4.5 6.5 8.5 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Casc1 PF12366.3 ESA00417.1 - 7 6.0 8.0 2 7.8 3.2 1.8 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 Hint PF01079.15 ESA00418.1 - 3.7e-16 58.9 0.0 5.7e-09 35.4 0.0 2.2 1 1 1 2 2 2 2 Hint module bZIP_1 PF00170.16 ESA00418.1 - 0.019 14.9 1.9 0.038 13.9 1.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor MbeD_MobD PF04899.7 ESA00418.1 - 0.024 14.5 0.2 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 MbeD/MobD like bZIP_2 PF07716.10 ESA00418.1 - 0.045 13.5 0.7 0.097 12.5 0.5 1.6 1 0 0 1 1 1 0 Basic region leucine zipper Herpes_UL6 PF01763.11 ESA00418.1 - 0.067 11.3 2.7 0.11 10.6 1.9 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like Spc7 PF08317.6 ESA00418.1 - 0.28 9.8 4.6 0.39 9.3 3.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.10 ESA00418.1 - 0.31 10.5 2.4 0.65 9.5 1.7 1.6 1 0 0 1 1 1 0 Septum formation initiator TMF_DNA_bd PF12329.3 ESA00418.1 - 0.6 9.9 8.3 1 9.2 5.7 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2577 PF10844.3 ESA00418.1 - 1.6 8.8 4.6 3.8 7.6 3.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2577) Spc24 PF08286.6 ESA00418.1 - 3.7 7.2 8.2 2.5 7.7 2.6 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Proteasome PF00227.21 ESA00419.1 - 7.3e-56 188.4 0.0 1.1e-55 187.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA00419.1 - 1.5e-11 43.4 0.3 3.5e-11 42.2 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Creatinase_N PF01321.13 ESA00420.1 - 1.4e-20 74.1 0.0 2.1e-19 70.3 0.0 2.0 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain HLH PF00010.21 ESA00421.1 - 0.018 14.6 4.1 0.02 14.5 2.5 1.3 1 1 0 1 1 1 0 Helix-loop-helix DNA-binding domain Nbl1_Borealin_N PF10444.4 ESA00421.1 - 0.19 11.0 1.4 0.21 10.9 1.0 1.1 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal ADH_zinc_N PF00107.21 ESA00422.1 - 3.7e-11 42.7 0.0 7.3e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA00422.1 - 8e-09 35.2 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESA00423.1 - 1.1e-22 80.0 0.0 1.9e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA00423.1 - 2.5e-11 43.2 0.0 1e-10 41.3 0.0 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 ESA00423.1 - 5.8e-11 43.3 0.0 9.6e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ACP_syn_III_C PF08541.5 ESA00423.1 - 0.033 14.2 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal CBFD_NFYB_HMF PF00808.18 ESA00424.1 - 4.5e-18 65.0 0.8 6.9e-18 64.4 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESA00424.1 - 2.1e-12 46.9 0.1 3.1e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 ESA00424.1 - 0.0085 15.8 0.1 0.014 15.1 0.1 1.4 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Leo1 PF04004.8 ESA00425.1 - 3.4e-39 134.2 2.1 3.4e-39 134.2 1.4 2.1 2 1 0 2 2 2 1 Leo1-like protein IPP-2 PF04979.9 ESA00426.1 - 4.8e-07 30.0 0.6 5.1e-07 30.0 0.4 1.0 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF2283 PF10049.4 ESA00427.1 - 2.1e-05 24.3 3.6 0.046 13.5 1.2 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF2283) IncA PF04156.9 ESA00427.1 - 1.7 8.1 13.1 3.9 7.0 9.1 1.7 1 0 0 1 1 1 0 IncA protein PHP PF02811.14 ESA00429.1 - 1.8e-11 44.1 0.0 2.5e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 PHP domain DNA_repr_REX1B PF14966.1 ESA00431.1 - 0.0043 17.3 2.4 0.15 12.4 0.0 2.4 1 1 1 2 2 2 1 DNA repair REX1-B PhaP_Bmeg PF09602.5 ESA00431.1 - 0.0065 16.3 3.9 0.0096 15.7 2.7 1.3 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF16 PF01519.11 ESA00431.1 - 0.01 16.0 7.3 0.02 15.0 5.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 PspB PF06667.7 ESA00431.1 - 0.014 15.3 2.0 0.045 13.7 0.3 2.3 2 0 0 2 2 2 0 Phage shock protein B Prefoldin PF02996.12 ESA00431.1 - 0.091 12.4 4.8 1.4 8.5 0.6 2.3 2 0 0 2 2 2 0 Prefoldin subunit GrpE PF01025.14 ESA00431.1 - 0.11 12.0 6.2 0.15 11.6 3.7 1.7 1 1 1 2 2 2 0 GrpE IncA PF04156.9 ESA00431.1 - 0.12 11.9 6.7 0.17 11.4 4.6 1.3 1 0 0 1 1 1 0 IncA protein DUF342 PF03961.8 ESA00431.1 - 0.21 9.9 8.0 0.27 9.6 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3492 PF11997.3 ESA00431.1 - 0.4 10.1 2.8 0.23 10.9 0.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3492) Matrilin_ccoil PF10393.4 ESA00431.1 - 0.41 10.0 3.6 1.9 7.9 0.4 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF2762 PF10960.3 ESA00431.1 - 0.57 9.9 6.1 1.3 8.8 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2762) TMF_DNA_bd PF12329.3 ESA00431.1 - 1.2 9.0 7.6 2.2 8.1 1.1 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 ESA00431.1 - 1.3 9.4 6.7 2.5 8.5 2.4 2.4 1 1 1 2 2 2 0 SlyX NPV_P10 PF05531.7 ESA00431.1 - 1.5 9.1 9.6 1.4 9.2 3.0 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.8 ESA00431.1 - 1.8 7.5 6.2 1.2 8.1 3.2 1.4 1 1 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.14 ESA00431.1 - 2.3 5.9 6.4 2.4 5.9 4.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliJ PF02050.11 ESA00431.1 - 3.1 7.8 9.4 1.6 8.8 2.6 2.7 2 1 1 3 3 3 0 Flagellar FliJ protein FadA PF09403.5 ESA00431.1 - 5.1 7.1 9.6 0.78 9.7 3.3 2.2 2 1 0 2 2 1 0 Adhesion protein FadA DUF4407 PF14362.1 ESA00431.1 - 5.2 5.9 8.9 7.1 5.4 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF972 PF06156.8 ESA00431.1 - 7.2 7.0 7.6 7 7.0 4.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Paramyxo_NS_C PF02725.9 ESA00431.1 - 8.4 5.9 8.2 2.1 7.9 2.4 2.0 2 0 0 2 2 2 0 Non-structural protein C ACDC PF14733.1 ESA00432.1 - 0.32 11.1 4.6 0.34 11.0 1.2 2.3 2 1 0 2 2 2 0 AP2-coincident C-terminal zf-BED PF02892.10 ESA00433.1 - 0.012 15.3 0.8 0.032 14.0 0.6 1.8 1 0 0 1 1 1 0 BED zinc finger Ded_cyto PF06920.8 ESA00433.1 - 0.022 14.0 3.0 0.36 10.1 0.1 2.2 1 1 1 2 2 2 0 Dedicator of cytokinesis Telomerase_RBD PF12009.3 ESA00433.1 - 0.25 11.2 3.2 0.33 10.8 1.7 1.6 1 1 0 1 1 1 0 Telomerase ribonucleoprotein complex - RNA binding domain DUF2121 PF09894.4 ESA00434.1 - 0.0018 17.6 3.0 0.0018 17.6 2.1 1.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2121) DUF812 PF05667.6 ESA00434.1 - 0.0036 15.8 0.1 0.0038 15.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Nop52 PF05997.7 ESA00434.1 - 0.01 15.2 0.4 0.014 14.8 0.3 1.2 1 0 0 1 1 1 0 Nucleolar protein,Nop52 HMG_box PF00505.14 ESA00436.1 - 0.036 14.3 0.6 0.068 13.4 0.4 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box DLD PF14878.1 ESA00436.1 - 0.067 13.3 0.0 0.077 13.1 0.0 1.2 1 0 0 1 1 1 0 Death-like domain of SPT6 MSC PF09402.5 ESA00436.1 - 0.079 11.6 1.2 0.085 11.5 0.8 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain DUF1462 PF07315.6 ESA00439.1 - 0.037 14.0 0.4 0.037 14.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1462) IL1_propep PF02394.11 ESA00439.1 - 0.088 13.2 3.4 0.079 13.3 1.4 1.6 1 1 0 1 1 1 0 Interleukin-1 propeptide Lactonase PF10282.4 ESA00440.1 - 0.047 12.7 0.2 21 4.0 0.0 2.8 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller Sel1 PF08238.7 ESA00441.1 - 2.2e-52 174.2 6.5 8.8e-12 45.2 0.4 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_17 PF13431.1 ESA00441.1 - 0.056 13.6 2.4 10 6.5 0.0 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat COX4_pro_2 PF07835.7 ESA00441.1 - 0.066 13.1 0.1 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV TPR_6 PF13174.1 ESA00441.1 - 0.72 10.4 4.2 19 6.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Exo_endo_phos_2 PF14529.1 ESA00442.1 - 4.5e-10 39.1 0.7 1.1e-09 37.9 0.5 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA00442.1 - 1.2e-08 35.2 0.0 1.7e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family POTRA_1 PF08478.5 ESA00442.1 - 0.0075 16.2 1.1 0.038 14.0 0.1 2.4 2 0 0 2 2 2 1 POTRA domain, FtsQ-type FlaF PF07309.6 ESA00442.1 - 0.012 15.4 0.7 0.66 9.8 0.2 2.6 2 1 0 2 2 2 0 Flagellar protein FlaF DUF4047 PF13256.1 ESA00442.1 - 0.19 11.6 3.6 0.21 11.5 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Rep_fac_C PF08542.6 ESA00443.1 - 0.078 12.9 0.4 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 Replication factor C C-terminal domain lci PF12197.3 ESA00445.1 - 3.2 7.4 4.9 1.7 8.3 0.9 2.4 2 1 1 3 3 3 0 Bacillus cereus group antimicrobial protein DUF2072 PF09845.4 ESA00447.1 - 0.047 13.6 0.3 0.064 13.1 0.2 1.3 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) MULE PF10551.4 ESA00448.1 - 1.5e-08 34.6 2.1 4.2e-07 30.0 0.1 3.4 3 0 0 3 3 3 1 MULE transposase domain BCS1_N PF08740.6 ESA00449.1 - 4.7e-06 26.3 0.6 0.038 13.5 0.0 4.1 5 0 0 5 5 5 2 BCS1 N terminal phiKZ_IP PF12699.2 ESA00449.1 - 0.0066 15.4 0.1 4 6.2 0.0 3.3 3 0 0 3 3 3 1 phiKZ-like phage internal head proteins EFG_II PF14492.1 ESA00449.1 - 0.047 13.5 0.0 48 3.9 0.0 4.0 4 0 0 4 4 4 0 Elongation Factor G, domain II zf-dskA_traR PF01258.12 ESA00449.1 - 0.2 11.3 15.3 4.6 7.0 0.2 4.4 3 1 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger zf-ribbon_3 PF13248.1 ESA00449.1 - 0.24 10.6 18.6 7.3 5.9 0.2 5.5 5 0 0 5 5 5 0 zinc-ribbon domain DUF4413 PF14372.1 ESA00449.1 - 0.32 10.9 6.2 7.5 6.6 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) Sel1 PF08238.7 ESA00450.1 - 1.8e-38 130.0 21.5 1.2e-09 38.5 0.3 5.3 5 0 0 5 5 5 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00450.1 - 6e-18 64.8 0.0 9.8e-18 64.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00450.1 - 2.6e-16 59.5 0.0 5.4e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HTH_7 PF02796.10 ESA00450.1 - 0.022 14.5 0.7 15 5.5 0.0 3.9 4 0 0 4 4 4 0 Helix-turn-helix domain of resolvase MIT PF04212.13 ESA00450.1 - 0.86 9.5 7.8 15 5.5 0.2 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA00450.1 - 3.5 7.6 11.5 4 7.4 2.8 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00450.1 - 3.8 7.6 15.3 39 4.4 0.1 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA00450.1 - 6.1 6.7 10.5 3.6 7.5 0.5 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.27 ESA00451.1 - 7.6e-37 123.8 10.2 1.8e-09 37.1 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA00451.1 - 2.1e-05 24.3 0.6 0.11 12.1 0.0 3.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.1 ESA00451.1 - 0.013 15.7 0.0 1.2 9.5 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain PQQ_2 PF13360.1 ESA00451.1 - 0.027 13.9 0.4 0.45 9.9 0.0 2.7 2 1 1 3 3 3 0 PQQ-like domain Conotoxin PF02950.12 ESA00452.1 - 0.022 15.5 0.1 0.043 14.6 0.1 1.5 1 0 0 1 1 1 0 Conotoxin Pkinase PF00069.20 ESA00453.1 - 1.3e-70 237.5 0.0 1.5e-70 237.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00453.1 - 5.7e-29 100.9 0.0 7.8e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00453.1 - 6e-09 35.2 0.2 2.1e-06 26.9 0.1 2.1 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.17 ESA00453.1 - 0.00042 19.7 0.1 0.0006 19.2 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA00453.1 - 0.057 12.4 0.2 0.085 11.9 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA00453.1 - 0.095 12.4 0.0 0.16 11.6 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family MMS1_N PF10433.4 ESA00455.1 - 4.1e-74 249.5 0.3 6.9e-74 248.7 0.2 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 ESA00455.1 - 1.8e-25 89.7 0.7 2.7e-25 89.1 0.1 1.6 2 0 0 2 2 2 1 CPSF A subunit region Astro_capsid PF03115.9 ESA00456.1 - 0.37 8.9 1.4 0.52 8.4 1.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Herpes_LMP1 PF05297.6 ESA00456.1 - 1.4 7.7 7.2 2.2 7.1 5.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) A2L_zn_ribbon PF08792.5 ESA00456.1 - 5 6.7 9.3 2.3 7.7 0.1 3.5 3 0 0 3 3 3 0 A2L zinc ribbon domain DUF2469 PF10611.4 ESA00457.1 - 0.016 15.5 0.4 0.073 13.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2469) Pkinase PF00069.20 ESA00458.1 - 4.8e-44 150.4 0.2 2.8e-43 147.9 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00458.1 - 4.9e-39 133.9 0.0 8e-37 126.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 ESA00458.1 - 0.00044 19.6 0.0 0.00098 18.5 0.0 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA00458.1 - 0.0026 17.5 0.1 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA00458.1 - 0.05 12.6 0.1 0.084 11.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PUD PF03714.9 ESA00459.1 - 0.00024 21.1 4.4 0.018 15.1 0.3 3.1 2 1 1 3 3 3 2 Bacterial pullanase-associated domain Dimer_Tnp_hAT PF05699.9 ESA00460.1 - 3.4e-16 58.6 0.2 3.6e-16 58.5 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RNase_H PF00075.19 ESA00461.1 - 7e-08 32.8 0.1 2.4e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 RNase H DUF3978 PF13123.1 ESA00462.1 - 0.03 13.7 0.5 0.035 13.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3978) DUF2121 PF09894.4 ESA00462.1 - 0.06 12.6 0.5 0.059 12.6 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) PrgU PF09627.5 ESA00462.1 - 0.094 12.3 0.4 0.092 12.3 0.3 1.1 1 0 0 1 1 1 0 PrgU-like protein Pkinase PF00069.20 ESA00464.1 - 4.1e-48 163.8 0.0 5.5e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00464.1 - 5.2e-48 163.3 0.0 6.2e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA00464.1 - 2.1e-05 23.6 0.0 0.0011 18.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like WaaY PF06176.6 ESA00464.1 - 0.0017 17.6 0.1 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA00464.1 - 0.0025 17.5 0.2 0.025 14.3 0.2 2.4 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA00464.1 - 0.0072 15.6 0.2 0.016 14.5 0.1 1.6 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA00464.1 - 0.033 13.5 0.1 0.079 12.2 0.0 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA00464.1 - 0.077 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PPP4R2 PF09184.6 ESA00465.1 - 2.9 7.3 22.9 4.4 6.7 15.8 1.2 1 0 0 1 1 1 0 PPP4R2 Peptidase_S24 PF00717.18 ESA00474.1 - 9.1e-12 44.4 0.2 1.5e-11 43.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like Pterin_4a PF01329.14 ESA00475.1 - 1.1e-32 111.6 0.1 1.2e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase VWA_2 PF13519.1 ESA00476.1 - 6.8e-05 23.0 0.0 0.0002 21.5 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain TUG-UBL1 PF11470.3 ESA00477.1 - 2.3e-19 69.0 0.1 6.8e-19 67.5 0.0 1.9 1 0 0 1 1 1 1 GLUT4 regulating protein TUG UBX PF00789.15 ESA00477.1 - 4.4e-16 58.7 0.1 2e-11 43.7 0.0 2.9 2 0 0 2 2 2 2 UBX domain UN_NPL4 PF11543.3 ESA00477.1 - 0.00053 20.2 0.0 0.0043 17.3 0.0 2.6 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 Epimerase PF01370.16 ESA00478.1 - 1.5e-39 135.8 0.0 1.2e-38 132.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA00478.1 - 4.1e-09 35.5 0.0 6.6e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 ESA00478.1 - 5.7e-09 35.2 0.0 3.9e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESA00478.1 - 1.7e-08 33.7 0.2 5.6e-05 22.1 0.2 3.0 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 ESA00478.1 - 4e-07 29.2 0.1 0.0037 16.2 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 ESA00478.1 - 0.00069 19.6 0.0 0.001 19.0 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ESA00478.1 - 0.053 13.4 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Gpi16 PF04113.9 ESA00479.1 - 2.3e-173 577.2 0.6 1.7e-171 571.0 0.4 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Fcf2 PF08698.6 ESA00480.1 - 7.4e-35 118.9 0.2 7.4e-35 118.9 0.1 1.4 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing RdRP PF05183.7 ESA00482.1 - 5.9e-111 371.9 0.1 8.2e-111 371.4 0.1 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase MMtag PF10159.4 ESA00483.1 - 4.4e-21 74.7 0.7 1.1e-20 73.4 0.5 1.7 1 0 0 1 1 1 1 Kinase phosphorylation protein DUF1777 PF08648.7 ESA00483.1 - 8.8 6.0 48.0 3.6 7.3 17.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1777) WHIM2 PF15613.1 ESA00484.1 - 0.04 13.8 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 Patched PF02460.13 ESA00485.1 - 9.4e-84 281.8 16.2 1.3e-82 278.0 11.4 2.1 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 ESA00485.1 - 3.7e-55 185.5 17.9 2.2e-52 176.5 2.6 3.0 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 ESA00485.1 - 0.0024 16.6 2.7 0.0024 16.6 1.8 2.2 2 0 0 2 2 2 1 MMPL family ACR_tran PF00873.14 ESA00485.1 - 0.08 10.3 13.1 0.0018 15.8 3.8 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family RhoGEF PF00621.15 ESA00486.1 - 3.7e-10 39.9 3.1 1.2e-09 38.3 0.1 3.0 2 2 0 2 2 2 1 RhoGEF domain PH PF00169.24 ESA00486.1 - 0.00015 21.9 2.4 0.00076 19.6 0.1 2.9 2 1 0 2 2 2 1 PH domain Ran_BP1 PF00638.13 ESA00486.1 - 0.025 14.6 1.9 0.049 13.6 0.5 2.1 2 0 0 2 2 2 0 RanBP1 domain DSPc PF00782.15 ESA00489.1 - 8.5e-31 106.2 0.0 1.6e-30 105.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.15 ESA00489.1 - 3.5e-07 30.5 0.0 6.9e-05 23.1 0.0 2.7 2 1 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.22 ESA00489.1 - 0.00022 20.6 0.0 0.00038 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESA00489.1 - 0.0061 16.6 0.1 0.019 15.0 0.0 1.8 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.8 ESA00489.1 - 0.038 13.3 0.0 0.078 12.3 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESA00489.1 - 0.1 12.8 0.0 0.41 10.8 0.0 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family PAZ PF02170.17 ESA00490.1 - 3.2e-22 78.2 1.3 4.6e-22 77.7 0.9 1.2 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA00490.1 - 6.6e-18 63.8 0.2 1.5e-17 62.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1785) Sterile PF03015.14 ESA00490.1 - 0.12 12.5 0.3 0.3 11.3 0.2 1.6 1 0 0 1 1 1 0 Male sterility protein DUF3907 PF13047.1 ESA00490.1 - 0.13 11.9 0.1 0.21 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) DUF3760 PF12586.3 ESA00491.1 - 0.12 12.2 0.5 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) zf-LITAF-like PF10601.4 ESA00493.1 - 6.5e-22 77.1 4.8 6.5e-22 77.1 3.4 1.8 2 1 0 2 2 2 1 LITAF-like zinc ribbon domain zinc_ribbon_4 PF13717.1 ESA00493.1 - 0.0036 16.9 1.3 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESA00493.1 - 0.0041 16.6 1.3 0.25 10.9 0.0 2.4 2 0 0 2 2 2 1 zinc-ribbon domain DUF1272 PF06906.6 ESA00493.1 - 0.0096 15.7 3.8 0.13 12.0 0.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1272) Sgf11 PF08209.6 ESA00493.1 - 0.028 13.7 2.8 3.2 7.1 0.2 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) TAF1D PF15333.1 ESA00493.1 - 0.031 14.0 0.7 0.036 13.8 0.5 1.2 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D zf-C4_Topoisom PF01396.14 ESA00493.1 - 0.032 13.7 1.5 4.1 6.9 0.1 2.8 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger UPF0547 PF10571.4 ESA00493.1 - 0.04 13.6 2.0 2.3 7.9 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-ribbon_3 PF13248.1 ESA00493.1 - 0.041 13.1 2.9 1.5 8.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Ribosomal_L32p PF01783.18 ESA00493.1 - 0.054 13.6 0.4 0.054 13.6 0.3 2.2 2 0 0 2 2 2 0 Ribosomal L32p protein family SR-25 PF10500.4 ESA00493.1 - 0.055 12.9 5.6 0.077 12.4 3.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4614 PF15391.1 ESA00493.1 - 0.083 12.6 4.1 0.1 12.3 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Zn_Tnp_IS1 PF03811.8 ESA00493.1 - 0.13 11.7 5.0 1.9 8.0 0.1 2.8 3 0 0 3 3 3 0 InsA N-terminal domain zf-RING_4 PF14570.1 ESA00493.1 - 0.15 11.6 5.7 0.53 9.9 0.7 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain COX7C PF02935.11 ESA00493.1 - 0.33 10.7 4.0 0.85 9.4 2.8 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc MDM1 PF15501.1 ESA00493.1 - 0.49 9.2 6.1 0.6 8.9 4.2 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 TF_Zn_Ribbon PF08271.7 ESA00493.1 - 0.64 9.3 9.7 1.1 8.6 0.2 2.7 3 0 0 3 3 3 0 TFIIB zinc-binding E7 PF00527.13 ESA00493.1 - 1.3 9.2 9.2 0.052 13.6 0.7 2.3 2 1 0 2 2 2 0 E7 protein, Early protein Zn-ribbon_8 PF09723.5 ESA00493.1 - 3.3 7.7 9.3 3.5 7.6 0.0 2.7 3 0 0 3 3 2 0 Zinc ribbon domain NOB1_Zn_bind PF08772.6 ESA00494.1 - 5.1e-19 67.8 0.3 1.1e-18 66.8 0.2 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Ogr_Delta PF04606.7 ESA00494.1 - 0.00034 20.1 0.1 0.00077 19.0 0.0 1.6 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger AF1Q PF15017.1 ESA00494.1 - 0.0098 15.7 3.9 0.019 14.8 2.5 1.8 1 1 0 1 1 1 1 Drug resistance and apoptosis regulator zf-ribbon_3 PF13248.1 ESA00494.1 - 0.019 14.1 0.1 0.038 13.1 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Pkinase PF00069.20 ESA00498.1 - 1.6e-07 30.7 0.0 2e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00498.1 - 4.5e-05 22.6 0.0 5.7e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RecO_N_2 PF13114.1 ESA00498.1 - 0.01 15.5 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 0 RecO N terminal TraT PF05818.7 ESA00499.1 - 0.16 11.3 1.3 0.22 10.9 0.1 1.7 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein BCS1_N PF08740.6 ESA00500.1 - 0.0083 15.7 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 BCS1 N terminal NOB1_Zn_bind PF08772.6 ESA00501.1 - 0.0023 17.7 19.3 0.37 10.6 0.4 4.5 4 0 0 4 4 4 3 Nin one binding (NOB1) Zn-ribbon like BCS1_N PF08740.6 ESA00501.1 - 0.0059 16.2 0.2 4.8 6.7 0.0 3.5 4 0 0 4 4 4 2 BCS1 N terminal V-SNARE PF05008.10 ESA00501.1 - 0.016 15.3 0.9 3.5 7.8 0.0 3.4 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF3279 PF11682.3 ESA00501.1 - 0.057 12.9 16.5 0.17 11.4 0.2 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3279) DUF4413 PF14372.1 ESA00501.1 - 0.1 12.6 16.6 6.1 6.8 0.3 5.5 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) DnaJ_CXXCXGXG PF00684.14 ESA00501.1 - 5.8 7.0 13.3 50 4.0 0.1 4.3 4 0 0 4 4 4 0 DnaJ central domain Aa_trans PF01490.13 ESA00502.1 - 1.1e-63 215.1 28.2 1.5e-63 214.7 19.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Bac_rhodopsin PF01036.13 ESA00502.1 - 0.081 12.2 12.9 0.02 14.2 6.4 1.9 2 0 0 2 2 2 0 Bacteriorhodopsin-like protein Glyco_hydro_35 PF01301.14 ESA00503.1 - 2.2e-63 214.5 0.5 4.8e-46 157.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.1 ESA00503.1 - 7.9e-14 51.8 1.9 1.4e-05 25.3 0.4 2.6 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain Glyco_hydro_42 PF02449.10 ESA00503.1 - 1.2e-05 24.5 0.0 2.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase Cellulase PF00150.13 ESA00503.1 - 0.00017 20.9 0.0 0.00051 19.3 0.0 1.8 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) DUF3870 PF12986.2 ESA00504.1 - 0.89 9.8 4.1 5.2 7.3 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3870) INCENP_N PF12178.3 ESA00505.1 - 0.059 12.9 0.4 0.21 11.1 0.1 1.8 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal HMG_box PF00505.14 ESA00506.1 - 2.5e-23 82.1 2.9 2.7e-23 81.9 2.0 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA00506.1 - 4.9e-10 39.6 2.4 5.4e-10 39.4 1.7 1.0 1 0 0 1 1 1 1 HMG-box domain F-box-like PF12937.2 ESA00507.1 - 9.6e-07 28.4 0.1 2.3e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like CCDC142 PF14923.1 ESA00507.1 - 0.087 11.1 0.3 0.11 10.7 0.2 1.1 1 0 0 1 1 1 0 Coiled-coil protein 142 SAM_PNT PF02198.11 ESA00508.1 - 0.0031 17.2 0.0 0.0083 15.8 0.0 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Atg14 PF10186.4 ESA00509.1 - 9.1e-25 87.2 0.4 1.3e-24 86.6 0.2 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 GalP_UDP_transf PF01087.17 ESA00510.1 - 3.8e-69 232.4 0.9 5.6e-69 231.8 0.6 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.12 ESA00510.1 - 1.4e-39 135.2 0.0 2.7e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain WG_beta_rep PF14903.1 ESA00510.1 - 0.011 15.9 0.2 0.083 13.1 0.0 2.4 2 0 0 2 2 2 0 WG containing repeat BAG PF02179.11 ESA00511.1 - 1.2e-09 38.1 0.0 2e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 BAG domain ubiquitin PF00240.18 ESA00511.1 - 4.6e-09 35.5 0.0 1.3e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 ESA00511.1 - 0.012 15.8 0.0 0.052 13.8 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin-like domain Atg14 PF10186.4 ESA00512.1 - 0.46 9.3 6.8 0.58 9.0 4.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Myb_DNA-bind_3 PF12776.2 ESA00512.1 - 3.2 8.4 7.8 25 5.5 1.6 2.9 1 1 2 3 3 3 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 ESA00513.1 - 6.1e-13 48.5 0.5 8.9e-13 47.9 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00513.1 - 2.6e-08 33.2 0.1 1.5e-07 30.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA00513.1 - 0.0014 18.0 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 ESA00513.1 - 0.0031 17.1 0.2 0.0069 15.9 0.1 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA00513.1 - 0.031 14.0 0.0 2.8 7.5 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA00513.1 - 0.037 13.0 0.0 0.067 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC45 PF02724.9 ESA00513.1 - 0.068 11.1 0.6 0.086 10.8 0.4 1.1 1 0 0 1 1 1 0 CDC45-like protein HTH_22 PF13309.1 ESA00513.1 - 0.14 11.9 0.0 0.42 10.4 0.0 1.7 1 0 0 1 1 1 0 HTH domain YL1 PF05764.8 ESA00513.1 - 0.43 10.1 3.4 0.71 9.4 2.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.7 ESA00513.1 - 7.5 4.3 9.0 11 3.7 6.2 1.1 1 0 0 1 1 1 0 Nop14-like family FAM92 PF06730.6 ESA00515.1 - 0.027 13.8 0.1 0.029 13.6 0.0 1.0 1 0 0 1 1 1 0 FAM92 protein Uma2 PF05685.7 ESA00518.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease APH PF01636.18 ESA00519.1 - 6.8e-09 35.8 0.0 8.1e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.9 ESA00519.1 - 0.00099 18.1 0.0 0.0011 17.9 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 ESA00520.1 - 1.4e-06 28.1 0.0 2.1e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ESA00520.1 - 5.7e-05 22.4 1.1 9e-05 21.7 0.1 1.7 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.15 ESA00520.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.6 ESA00520.1 - 0.0056 15.3 0.3 0.011 14.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) GatB_Yqey PF02637.13 ESA00520.1 - 0.03 14.0 0.5 0.12 12.1 0.2 2.0 3 0 0 3 3 3 0 GatB domain IcmL PF11393.3 ESA00521.1 - 0.017 15.0 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 Macrophage killing protein with similarity to conjugation protein DUF3579 PF12112.3 ESA00523.1 - 0.051 13.4 0.2 0.071 13.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3579) DUF241 PF03087.9 ESA00524.1 - 0.087 12.2 4.4 0.15 11.5 1.3 2.2 2 1 0 2 2 2 0 Arabidopsis protein of unknown function DUF745 PF05335.8 ESA00524.1 - 0.18 11.2 0.6 0.33 10.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Phage_Orf51 PF06194.6 ESA00524.1 - 0.21 11.7 2.2 0.88 9.7 0.0 2.7 3 0 0 3 3 3 0 Phage Conserved Open Reading Frame 51 DUF3888 PF13027.1 ESA00529.1 - 0.048 13.5 0.1 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3888) L6_membrane PF05805.7 ESA00529.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 L6 membrane protein ETRAMP PF09716.5 ESA00529.1 - 0.16 11.9 0.2 0.41 10.6 0.1 1.8 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Yip1 PF04893.12 ESA00530.1 - 0.072 12.5 4.3 1.5 8.3 0.2 2.2 2 0 0 2 2 2 0 Yip1 domain DPM2 PF07297.7 ESA00530.1 - 0.28 11.4 3.1 0.83 9.9 2.1 1.8 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) RNase_H PF00075.19 ESA00531.1 - 0.06 13.6 0.1 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 RNase H zf-Sec23_Sec24 PF04810.10 ESA00531.1 - 0.22 11.1 3.4 0.18 11.4 0.5 2.0 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger zf-primase PF09329.6 ESA00533.1 - 0.39 10.3 2.2 0.33 10.5 0.2 1.9 2 0 0 2 2 2 0 Primase zinc finger Transposase_21 PF02992.9 ESA00534.1 - 0.061 12.3 0.8 0.33 9.9 0.0 2.3 1 1 2 3 3 3 0 Transposase family tnp2 CM_2 PF01817.16 ESA00535.1 - 0.075 13.1 0.2 0.7 10.0 0.0 2.1 2 0 0 2 2 2 0 Chorismate mutase type II Imm36 PF15597.1 ESA00535.1 - 0.17 12.0 1.7 0.32 11.1 1.1 1.7 1 1 0 1 1 1 0 Immunity protein 36 RNase_H2-Ydr279 PF09468.5 ESA00535.1 - 0.21 10.7 6.5 0.24 10.5 4.5 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Sel1 PF08238.7 ESA00537.1 - 4.7e-60 198.6 17.0 2.7e-09 37.3 0.6 9.0 9 0 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.1 ESA00537.1 - 0.00036 20.7 10.1 6 7.5 0.1 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00537.1 - 0.0016 18.4 1.8 7.1 7.0 0.0 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat Colicin_immun PF09204.5 ESA00537.1 - 0.019 15.0 1.6 22 5.2 0.0 4.0 2 2 3 5 5 5 0 Bacterial self-protective colicin-like immunity NUMOD1 PF07453.8 ESA00537.1 - 0.19 11.6 0.1 0.19 11.6 0.1 3.8 4 0 0 4 4 4 0 NUMOD1 domain Thymidylate_kin PF02223.12 ESA00538.1 - 4.4e-05 22.9 0.3 0.00013 21.4 0.0 1.8 2 0 0 2 2 2 1 Thymidylate kinase KTI12 PF08433.5 ESA00538.1 - 0.00017 20.9 0.1 0.00025 20.3 0.1 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_14 PF13173.1 ESA00538.1 - 0.0003 20.6 0.9 0.00047 20.0 0.4 1.6 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA00538.1 - 0.00031 20.5 0.8 0.00037 20.2 0.5 1.2 1 0 0 1 1 1 1 Archaeal ATPase NTPase_1 PF03266.10 ESA00538.1 - 0.00031 20.5 0.5 0.00051 19.7 0.3 1.5 1 1 0 1 1 1 1 NTPase cobW PF02492.14 ESA00538.1 - 0.00037 19.9 0.2 0.00095 18.6 0.1 1.6 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 ESA00538.1 - 0.00088 18.4 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 ESA00538.1 - 0.0012 19.6 0.0 0.0021 18.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 ESA00538.1 - 0.0051 15.8 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain NB-ARC PF00931.17 ESA00538.1 - 0.0053 15.6 0.0 0.011 14.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 ESA00538.1 - 0.0068 16.4 0.0 0.0085 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 ESA00538.1 - 0.0075 16.5 0.7 0.0075 16.5 0.5 1.8 2 1 0 2 2 1 1 AAA domain NACHT PF05729.7 ESA00538.1 - 0.008 15.8 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain MobB PF03205.9 ESA00538.1 - 0.0091 15.6 0.2 0.019 14.6 0.0 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESA00538.1 - 0.015 15.0 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain Viral_helicase1 PF01443.13 ESA00538.1 - 0.036 13.5 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SRP54 PF00448.17 ESA00538.1 - 0.045 13.1 0.0 0.086 12.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 ESA00538.1 - 0.046 13.6 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA00538.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA PF00004.24 ESA00538.1 - 0.064 13.4 0.1 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESA00538.1 - 0.074 13.3 0.6 0.097 12.9 0.4 1.4 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 ESA00538.1 - 0.081 13.0 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA00538.1 - 0.084 11.7 0.1 0.14 10.9 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Arf PF00025.16 ESA00538.1 - 0.086 12.0 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family TrwB_AAD_bind PF10412.4 ESA00538.1 - 0.087 11.4 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 ESA00538.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 ESA00538.1 - 0.11 11.2 0.4 0.17 10.6 0.0 1.4 2 0 0 2 2 1 0 ArgK protein AAA_33 PF13671.1 ESA00538.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF4094 PF13334.1 ESA00539.1 - 0.085 13.2 0.1 0.085 13.2 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Striatin PF08232.7 ESA00539.1 - 0.12 12.6 6.4 0.072 13.4 1.4 2.6 2 0 0 2 2 2 0 Striatin family V_ATPase_I PF01496.14 ESA00539.1 - 0.19 9.5 4.1 0.46 8.2 2.8 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIVA PF05103.8 ESA00539.1 - 3.7 7.6 12.9 0.61 10.1 4.8 2.4 2 0 0 2 2 2 0 DivIVA protein Asp_protease_2 PF13650.1 ESA00540.1 - 2.8e-06 27.7 0.1 4.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA00540.1 - 5.1e-06 26.4 0.1 6.7e-06 26.0 0.1 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 ESA00540.1 - 1.6e-05 24.7 0.5 2.5e-05 24.1 0.3 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA00540.1 - 9.5e-05 21.9 0.3 0.00016 21.2 0.2 1.4 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A3 PF02160.10 ESA00540.1 - 0.0023 17.5 0.9 0.0031 17.1 0.6 1.1 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) gag-asp_proteas PF13975.1 ESA00540.1 - 0.0091 15.7 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease TIG PF01833.19 ESA00540.1 - 0.026 14.5 0.0 0.12 12.3 0.0 1.9 1 1 1 2 2 2 0 IPT/TIG domain Nsp1_C PF05064.8 ESA00540.1 - 0.031 13.9 0.1 0.061 12.9 0.1 1.6 1 1 0 1 1 1 0 Nsp1-like C-terminal region Peptidase_A2B PF12384.3 ESA00540.1 - 0.059 12.7 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Ty3 transposon peptidase DUF1108 PF06531.6 ESA00543.1 - 4.4 7.5 7.0 1.9 8.7 0.5 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1108) CAP PF00188.21 ESA00544.1 - 0.056 13.9 0.1 0.071 13.6 0.1 1.1 1 0 0 1 1 1 0 Cysteine-rich secretory protein family CS PF04969.11 ESA00546.1 - 1.9e-10 41.1 0.1 1.9e-10 41.1 0.1 2.2 2 0 0 2 2 2 1 CS domain DUF4045 PF13254.1 ESA00546.1 - 0.32 10.2 15.1 0.4 9.8 10.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) BTB PF00651.26 ESA00547.1 - 1e-15 57.6 0.1 1.8e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA00547.1 - 1.7e-12 47.5 0.1 5e-12 45.9 0.1 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA00547.1 - 7.2e-06 25.7 0.4 0.0002 21.1 0.2 2.8 1 1 2 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA00548.1 - 1.9e-12 47.3 0.5 1.9e-12 47.3 0.3 2.5 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA00548.1 - 0.0043 16.8 2.8 0.031 14.1 0.4 3.1 1 1 2 3 3 3 1 BTB And C-terminal Kelch Glyco_hydro_25 PF01183.15 ESA00548.1 - 0.036 13.8 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 25 ERG4_ERG24 PF01222.12 ESA00549.1 - 1.5e-136 455.4 22.1 1.7e-136 455.1 15.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF4234 PF14018.1 ESA00549.1 - 8.3 6.2 15.2 5.2 6.8 0.2 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF4234) LSM PF01423.17 ESA00550.1 - 3.5e-08 32.8 0.2 4.3e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain Gemin6 PF06372.7 ESA00550.1 - 0.13 11.6 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Gemin6 protein DUF4539 PF15072.1 ESA00551.1 - 1.9e-12 46.6 0.2 4.2e-12 45.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) DUF3385 PF11865.3 ESA00551.1 - 0.0079 16.1 0.4 0.018 14.9 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) Lipase_3 PF01764.20 ESA00552.1 - 7.7e-37 126.0 0.0 1.2e-36 125.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.17 ESA00552.1 - 0.0079 15.9 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.3 ESA00552.1 - 0.05 12.9 0.0 0.26 10.6 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.2 ESA00552.1 - 0.12 12.0 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pmp3 PF01679.12 ESA00553.1 - 1.5e-21 75.8 6.9 1.7e-21 75.6 4.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Dispanin PF04505.7 ESA00553.1 - 0.023 14.2 0.8 1.9 8.0 0.1 2.1 2 0 0 2 2 2 0 Interferon-induced transmembrane protein LRR19-TM PF15176.1 ESA00553.1 - 0.15 11.7 0.1 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF349 PF03993.7 ESA00557.1 - 0.0051 16.9 0.2 0.0051 16.9 0.2 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF349) Pkinase PF00069.20 ESA00558.1 - 0.00043 19.5 0.0 0.0005 19.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00558.1 - 0.0064 15.6 0.0 0.008 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_trans_2_3 PF13632.1 ESA00558.1 - 0.077 12.7 0.4 0.082 12.6 0.3 1.0 1 0 0 1 1 1 0 Glycosyl transferase family group 2 V-ATPase_C PF03223.10 ESA00560.1 - 0.0086 15.0 1.1 0.014 14.2 0.8 1.3 1 1 0 1 1 1 1 V-ATPase subunit C Mod_r PF07200.8 ESA00560.1 - 0.013 15.4 1.1 0.016 15.0 0.7 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Seryl_tRNA_N PF02403.17 ESA00560.1 - 0.051 13.5 3.1 0.071 13.1 2.1 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Microtub_assoc PF07989.6 ESA00560.1 - 0.058 13.2 3.4 0.25 11.1 1.9 2.0 1 1 0 1 1 1 0 Microtubule associated Wbp11 PF09429.5 ESA00560.1 - 0.14 12.1 3.2 0.24 11.4 2.2 1.3 1 0 0 1 1 1 0 WW domain binding protein 11 bZIP_1 PF00170.16 ESA00560.1 - 0.65 10.0 4.4 3.9 7.5 3.0 2.0 1 1 0 1 1 1 0 bZIP transcription factor NYD-SP28_assoc PF14775.1 ESA00560.1 - 0.77 9.4 6.0 3.5 7.3 0.5 2.3 1 1 1 2 2 2 0 Sperm tail C-terminal domain YvrJ PF12841.2 ESA00560.1 - 1.7 7.9 4.2 0.64 9.3 0.3 2.2 3 1 0 3 3 3 0 YvrJ protein family bZIP_2 PF07716.10 ESA00560.1 - 9 6.2 7.3 87 3.0 4.4 2.4 2 1 0 2 2 2 0 Basic region leucine zipper TLD PF07534.11 ESA00561.1 - 2.6e-16 59.8 1.1 7.4e-16 58.4 0.7 1.8 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA00561.1 - 5.9e-14 52.0 0.1 2.4e-13 50.0 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA00561.1 - 4.3e-05 23.2 0.6 0.00017 21.3 0.2 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF815 PF05673.8 ESA00564.1 - 0.064 12.1 0.0 0.067 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sec5 PF15469.1 ESA00566.1 - 0.0011 18.7 2.4 0.25 11.0 1.3 2.4 1 1 1 2 2 2 2 Exocyst complex component Sec5 ARPC4 PF05856.7 ESA00567.1 - 0.12 11.7 2.8 0.18 11.1 0.3 1.9 1 1 1 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) TPR_6 PF13174.1 ESA00570.1 - 0.00042 20.5 0.0 1.4 9.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF1474 PF07342.6 ESA00570.1 - 0.05 13.8 0.1 0.058 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) TPR_2 PF07719.12 ESA00570.1 - 0.083 12.8 0.1 13 5.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HEAT_2 PF13646.1 ESA00572.1 - 0.011 15.9 0.0 0.13 12.5 0.0 2.7 3 0 0 3 3 3 0 HEAT repeats HEAT PF02985.17 ESA00572.1 - 0.012 15.6 2.1 5 7.4 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat Arm PF00514.18 ESA00572.1 - 0.21 11.4 0.0 0.21 11.4 0.0 2.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat SHS2_Rpb7-N PF03876.12 ESA00573.1 - 8.7e-08 32.1 0.0 2.1e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Astacin PF01400.19 ESA00573.1 - 0.079 12.3 0.2 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Nop14 PF04147.7 ESA00574.1 - 0.11 10.4 8.6 0.14 10.0 6.0 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 ESA00574.1 - 1.2 8.0 10.6 2.2 7.2 7.4 1.4 1 0 0 1 1 1 0 BUD22 zf-BED PF02892.10 ESA00575.1 - 1.2e-08 34.6 0.3 1.5e-08 34.2 0.2 1.2 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.10 ESA00575.1 - 0.019 14.4 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-TRAF PF02176.13 ESA00575.1 - 0.05 13.9 3.0 0.08 13.3 2.1 1.4 1 1 0 1 1 1 0 TRAF-type zinc finger zf-C2H2_4 PF13894.1 ESA00575.1 - 0.058 13.7 1.1 0.16 12.3 0.5 1.9 2 1 0 2 2 2 0 C2H2-type zinc finger zf-CHCC PF10276.4 ESA00575.1 - 0.35 10.7 3.3 0.72 9.7 2.3 1.6 1 1 0 1 1 1 0 Zinc-finger domain Sel1 PF08238.7 ESA00576.1 - 5.3e-32 109.5 6.3 6.5e-08 32.9 0.1 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ESA00576.1 - 7.2e-06 26.1 3.4 0.015 15.7 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.15 ESA00576.1 - 0.28 11.2 2.3 9.2 6.4 0.0 3.4 3 0 0 3 3 3 0 PPR repeat RNA_pol_Rpc4 PF05132.9 ESA00577.1 - 5.6e-05 23.1 1.1 7.3e-05 22.7 0.8 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 OATP PF03137.15 ESA00577.1 - 0.014 13.4 0.0 0.016 13.3 0.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF912 PF06024.7 ESA00577.1 - 0.031 14.3 1.6 0.049 13.6 1.1 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Adaptin_binding PF10199.4 ESA00577.1 - 0.038 14.2 13.8 0.044 14.0 9.6 1.1 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Vfa1 PF08432.5 ESA00577.1 - 0.075 13.0 8.6 0.087 12.8 6.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sigma70_ner PF04546.8 ESA00577.1 - 0.17 11.4 11.1 0.22 11.1 7.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF506 PF04720.7 ESA00577.1 - 0.72 9.4 4.8 0.8 9.2 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) Nop14 PF04147.7 ESA00577.1 - 1.2 6.9 18.2 1.3 6.8 12.6 1.0 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.11 ESA00577.1 - 1.6 7.6 8.4 1.7 7.5 5.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1510 PF07423.6 ESA00577.1 - 1.8 7.8 13.5 2.1 7.6 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pox_Ag35 PF03286.9 ESA00577.1 - 2 7.8 13.9 2.3 7.7 9.7 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Upf2 PF04050.9 ESA00577.1 - 3.2 7.4 14.8 4 7.1 10.3 1.1 1 0 0 1 1 1 0 Up-frameshift suppressor 2 CDC45 PF02724.9 ESA00577.1 - 4.2 5.2 15.7 5 5.0 10.9 1.0 1 0 0 1 1 1 0 CDC45-like protein SGT1 PF07093.6 ESA00577.1 - 7.4 4.8 14.3 8.5 4.6 9.9 1.1 1 0 0 1 1 1 0 SGT1 protein CobT PF06213.7 ESA00577.1 - 8.2 5.4 17.1 9.5 5.2 11.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Astro_capsid PF03115.9 ESA00577.1 - 9 4.4 6.5 9.2 4.3 4.5 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor SSF PF00474.12 ESA00578.1 - 4.4e-11 42.0 24.2 5.9e-11 41.6 16.8 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family DUF3882 PF07066.6 ESA00578.1 - 0.044 13.6 0.0 0.11 12.4 0.0 1.5 2 0 0 2 2 2 0 Lactococcus phage M3 protein P35 PF02331.10 ESA00579.1 - 0.071 12.2 7.2 0.1 11.7 5.0 1.1 1 0 0 1 1 1 0 Apoptosis preventing protein PAH PF02671.16 ESA00579.1 - 0.36 10.4 3.1 9.4 5.9 0.5 2.6 2 0 0 2 2 2 0 Paired amphipathic helix repeat Spin-Ssty PF02513.12 ESA00580.1 - 0.31 10.6 4.4 4 7.0 0.1 3.0 2 0 0 2 2 2 0 Spin/Ssty Family BTB PF00651.26 ESA00581.1 - 3.1e-18 65.7 0.1 6.8e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA00581.1 - 1.6e-12 47.6 1.4 3.9e-12 46.3 0.1 2.2 2 0 0 2 2 2 1 TLD ZZ PF00569.12 ESA00581.1 - 8.3e-09 34.8 12.9 1.6e-08 33.9 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type BACK PF07707.10 ESA00581.1 - 0.00012 21.8 4.9 0.00052 19.8 0.3 3.8 3 1 1 4 4 4 1 BTB And C-terminal Kelch Dimerisation PF08100.6 ESA00581.1 - 0.089 12.6 0.1 0.31 10.9 0.1 2.0 1 0 0 1 1 1 0 Dimerisation domain Bromodomain PF00439.20 ESA00582.1 - 1.5e-11 44.0 4.4 1.6e-11 43.9 3.1 1.0 1 0 0 1 1 1 1 Bromodomain DUF2555 PF10742.4 ESA00582.1 - 0.0084 15.7 0.1 0.012 15.2 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2555) P22_AR_C PF10548.4 ESA00582.1 - 0.073 12.9 0.1 0.097 12.5 0.1 1.2 1 0 0 1 1 1 0 P22AR C-terminal domain DWNN PF08783.6 ESA00582.1 - 0.42 10.5 1.7 0.71 9.8 0.2 1.8 1 1 1 2 2 2 0 DWNN domain DUF1523 PF07509.6 ESA00582.1 - 2 7.6 5.2 1.1 8.5 0.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1523) Phage_int_SAM_3 PF14659.1 ESA00583.1 - 1.1 9.5 6.4 5 7.4 0.6 2.9 2 1 1 3 3 3 0 Phage integrase, N-terminal SAM-like domain ABC_membrane PF00664.18 ESA00584.1 - 5.6e-89 298.1 21.4 7.9e-47 159.9 6.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA00584.1 - 3.5e-69 231.3 0.1 6.7e-35 120.3 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA00584.1 - 4.9e-16 58.6 0.2 5e-07 29.1 0.0 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 ESA00584.1 - 3.1e-12 45.8 0.8 1.2e-05 24.1 0.0 3.2 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_21 PF13304.1 ESA00584.1 - 1.1e-10 41.9 0.9 0.016 15.1 0.0 5.2 4 1 0 5 5 5 3 AAA domain AAA_29 PF13555.1 ESA00584.1 - 3.1e-08 33.0 0.0 0.006 16.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 ESA00584.1 - 5.4e-08 33.6 0.0 0.0054 17.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 ESA00584.1 - 2.6e-07 30.2 0.1 0.018 14.4 0.0 3.7 4 0 0 4 4 3 2 AAA domain DUF258 PF03193.11 ESA00584.1 - 3.1e-07 29.7 0.0 0.011 14.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA00584.1 - 5.7e-06 25.9 0.1 1.4 8.2 0.0 4.4 4 0 0 4 4 4 2 AAA-like domain AAA_22 PF13401.1 ESA00584.1 - 5.7e-06 26.4 2.7 0.029 14.5 0.1 3.9 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESA00584.1 - 5.9e-06 26.6 0.3 0.41 10.9 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.1 ESA00584.1 - 9e-06 25.7 0.0 0.18 11.7 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain APS_kinase PF01583.15 ESA00584.1 - 2e-05 24.2 0.0 0.073 12.7 0.0 2.4 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_30 PF13604.1 ESA00584.1 - 0.00016 21.3 0.0 2.5 7.6 0.0 3.7 4 0 0 4 4 4 1 AAA domain DUF87 PF01935.12 ESA00584.1 - 0.00016 21.5 0.1 0.31 10.8 0.0 3.1 3 0 0 3 3 2 1 Domain of unknown function DUF87 G-alpha PF00503.15 ESA00584.1 - 0.00038 19.2 0.0 0.024 13.3 0.0 2.5 2 0 0 2 2 2 1 G-protein alpha subunit AAA_5 PF07728.9 ESA00584.1 - 0.00041 20.0 0.2 0.8 9.4 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESA00584.1 - 0.00062 18.9 0.1 0.48 9.4 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin SbcCD_C PF13558.1 ESA00584.1 - 0.00077 19.3 3.0 1.2 9.0 0.1 3.7 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.1 ESA00584.1 - 0.0012 18.5 0.0 2 8.2 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 ESA00584.1 - 0.0013 18.2 0.7 7 6.0 0.0 4.2 4 0 0 4 4 4 0 IstB-like ATP binding protein Sigma54_activat PF00158.21 ESA00584.1 - 0.0039 16.6 0.0 2.1 7.7 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF3987 PF13148.1 ESA00584.1 - 0.0041 15.7 0.0 1.5 7.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) RNA_helicase PF00910.17 ESA00584.1 - 0.0073 16.4 0.3 5.7 7.1 0.0 3.1 3 0 0 3 3 2 0 RNA helicase ATP-synt_ab PF00006.20 ESA00584.1 - 0.026 14.0 0.1 2.6 7.4 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.7 ESA00584.1 - 0.026 14.1 0.0 10 5.7 0.0 2.8 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.1 ESA00584.1 - 0.033 14.0 0.0 4.7 7.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 ESA00584.1 - 0.04 12.7 0.0 1.3 7.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.9 ESA00584.1 - 0.052 13.2 0.0 7.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 ESA00584.1 - 0.059 12.8 0.0 2 7.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Mg_chelatase PF01078.16 ESA00584.1 - 0.064 12.4 0.0 5.1 6.1 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESA00584.1 - 0.075 12.9 1.5 12 5.8 0.0 3.3 2 1 0 3 3 3 0 AAA domain AAA_23 PF13476.1 ESA00584.1 - 0.13 12.5 4.3 0.34 11.2 0.0 3.3 4 0 0 4 4 3 0 AAA domain Synapsin_N PF10581.4 ESA00584.1 - 0.15 11.8 0.7 3.5 7.5 0.0 2.8 3 0 0 3 3 2 0 Synapsin N-terminal MMR_HSR1 PF01926.18 ESA00584.1 - 0.2 11.5 2.8 9.8 6.1 0.1 3.2 2 2 0 2 2 2 0 50S ribosome-binding GTPase Sel1 PF08238.7 ESA00585.1 - 5.5e-110 357.4 55.8 4.7e-13 49.3 0.6 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_17 PF13431.1 ESA00585.1 - 1e-08 34.6 27.8 0.91 9.8 0.1 9.6 7 2 0 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00585.1 - 2.1e-07 30.9 30.1 1.1 9.9 0.2 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat MIT PF04212.13 ESA00585.1 - 3.9e-07 29.8 49.5 2.8 7.8 0.1 9.3 7 2 2 9 9 9 9 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA00585.1 - 1.5e-05 24.5 17.0 27 4.5 0.0 8.7 9 0 0 9 9 9 0 Lung surfactant protein D coiled-coil trimerisation Flu_M1_C PF08289.6 ESA00585.1 - 0.0011 18.9 0.0 25 4.9 0.0 5.1 1 1 5 6 6 6 0 Influenza Matrix protein (M1) C-terminal domain HTH_16 PF12645.2 ESA00585.1 - 0.13 12.1 10.3 11 6.0 0.0 5.8 7 0 0 7 7 7 0 Helix-turn-helix domain RRM_1 PF00076.17 ESA00589.1 - 0.0001 21.8 0.1 0.00052 19.5 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA00589.1 - 0.0014 18.5 0.0 0.006 16.5 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Dabb PF07876.7 ESA00589.1 - 0.12 12.7 1.0 0.48 10.9 0.0 2.5 3 0 0 3 3 3 0 Stress responsive A/B Barrel Domain zf-CCHC_4 PF14392.1 ESA00589.1 - 0.25 11.0 1.5 0.57 9.9 1.0 1.6 1 0 0 1 1 1 0 Zinc knuckle RNase_H PF00075.19 ESA00590.1 - 1.1e-11 45.2 0.2 1.7e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 RNase H UPF0731 PF14982.1 ESA00590.1 - 0.11 12.4 0.2 2.6 8.0 0.0 2.3 1 1 1 2 2 2 0 UPF0731 family Ribosomal_L35p PF01632.14 ESA00591.1 - 0.029 14.2 1.7 0.042 13.7 1.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L35 FlxA PF14282.1 ESA00592.1 - 0.0066 16.3 0.5 0.022 14.7 0.3 1.8 1 0 0 1 1 1 1 FlxA-like protein E1_DerP2_DerF2 PF02221.10 ESA00593.1 - 9.3e-09 35.6 0.2 1.2e-08 35.2 0.1 1.1 1 0 0 1 1 1 1 ML domain LRR_8 PF13855.1 ESA00595.1 - 0.0045 16.7 1.6 0.91 9.3 0.1 3.7 4 1 0 4 4 4 2 Leucine rich repeat Glyco_transf_49 PF13896.1 ESA00595.1 - 0.042 12.9 0.0 0.065 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl-transferase for dystroglycan LRR_4 PF12799.2 ESA00595.1 - 0.23 11.1 4.7 3.8 7.2 0.3 3.7 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) Alpha-amyl_C PF09071.5 ESA00596.1 - 0.0011 18.7 0.0 0.0036 17.0 0.0 1.9 1 0 0 1 1 1 1 Alpha-amylase, C terminal FYRC PF05965.9 ESA00596.1 - 0.093 12.5 0.1 0.63 9.8 0.1 2.3 1 1 0 1 1 1 0 F/Y rich C-terminus Transp_Tc5_C PF04236.10 ESA00597.1 - 0.78 10.0 4.2 0.98 9.6 0.2 2.4 2 1 0 2 2 2 0 Tc5 transposase C-terminal domain Sel1 PF08238.7 ESA00598.1 - 1e-23 83.1 4.9 3.3e-11 43.4 0.5 3.3 3 0 0 3 3 3 2 Sel1 repeat Mt_ATP-synt_D PF05873.7 ESA00598.1 - 0.053 13.1 0.1 0.06 12.9 0.1 1.2 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) MIT PF04212.13 ESA00598.1 - 0.085 12.7 3.3 1.7 8.6 0.1 2.7 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain Nab1 PF04902.7 ESA00599.1 - 0.07 12.6 0.4 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 Conserved region in Nab1 Sel1 PF08238.7 ESA00600.1 - 1.3e-151 489.7 94.5 3.6e-13 49.6 0.4 18.0 17 1 0 17 17 17 15 Sel1 repeat TPR_6 PF13174.1 ESA00600.1 - 4.1e-12 45.7 40.4 0.44 11.1 0.0 13.0 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_20 PF14561.1 ESA00600.1 - 2.7e-08 33.8 7.3 6.6 6.9 0.0 7.8 3 2 5 9 9 9 4 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA00600.1 - 5e-07 29.6 0.1 3.3 7.3 0.0 5.5 2 2 1 4 4 4 2 Caspase domain TPR_17 PF13431.1 ESA00600.1 - 0.00017 21.4 41.2 10 6.5 0.1 13.3 12 3 2 14 14 14 4 Tetratricopeptide repeat HTH_16 PF12645.2 ESA00600.1 - 0.095 12.6 17.6 22 5.0 0.0 7.8 9 0 0 9 9 9 0 Helix-turn-helix domain MIT PF04212.13 ESA00600.1 - 3.7 7.5 49.3 1.3 8.9 0.2 10.6 10 2 1 11 11 11 0 MIT (microtubule interacting and transport) domain Borrelia_REV PF03978.8 ESA00604.1 - 0.038 13.7 0.4 0.046 13.4 0.3 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Sel1 PF08238.7 ESA00605.1 - 2.6e-190 612.7 74.9 1.6e-09 38.0 0.3 25.1 24 1 1 25 25 25 24 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00605.1 - 1.4e-43 148.8 0.0 2.2e-43 148.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00605.1 - 2.1e-42 145.0 0.1 3.5e-42 144.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain TPR_6 PF13174.1 ESA00605.1 - 9.9e-06 25.6 41.7 3.5 8.2 0.1 14.9 16 0 0 16 16 16 3 Tetratricopeptide repeat Kdo PF06293.9 ESA00605.1 - 0.0009 18.3 0.0 0.0026 16.8 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA00605.1 - 0.13 12.0 0.3 0.2 11.3 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Anoctamin PF04547.7 ESA00606.1 - 0.038 12.6 1.2 0.049 12.2 0.9 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel DUF1103 PF06513.6 ESA00608.1 - 0.058 12.7 0.3 0.078 12.3 0.2 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) Pkinase_Tyr PF07714.12 ESA00609.1 - 9.9e-21 73.9 0.0 1.4e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00609.1 - 2.4e-18 66.2 0.2 4.5e-18 65.3 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain zinc-ribbons_6 PF07191.7 ESA00609.1 - 0.041 13.6 1.1 0.073 12.8 0.8 1.3 1 0 0 1 1 1 0 zinc-ribbons Chitin_synth_1 PF01644.12 ESA00610.1 - 7.2e-74 247.0 0.3 1.7e-73 245.7 0.1 1.7 2 0 0 2 2 2 1 Chitin synthase Chitin_synth_2 PF03142.10 ESA00610.1 - 1.7e-29 102.6 0.0 5e-22 77.9 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.6 ESA00610.1 - 2.3e-28 97.7 1.1 6.3e-28 96.2 0.5 2.0 2 0 0 2 2 2 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.1 ESA00610.1 - 2.5e-09 37.1 0.0 2.5e-09 37.1 0.0 2.9 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA00610.1 - 1e-07 31.9 0.0 4.1e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 GARS_A PF01071.14 ESA00613.1 - 2.6e-85 284.8 0.0 5.4e-85 283.8 0.0 1.5 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 ESA00613.1 - 9.8e-36 122.2 0.0 2e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain ATPgrasp_Ter PF15632.1 ESA00613.1 - 1.4e-10 40.4 0.0 3.2e-10 39.2 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 ESA00613.1 - 1.6e-09 37.8 0.0 5.9e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 ESA00613.1 - 2.4e-05 24.2 0.0 6.4e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 ESA00613.1 - 0.00018 20.8 0.0 0.00031 20.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_C PF02843.11 ESA00613.1 - 0.00034 20.7 0.0 0.00081 19.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain CPSase_L_D2 PF02786.12 ESA00613.1 - 0.00037 19.8 0.1 0.00056 19.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_2 PF08442.5 ESA00613.1 - 0.025 13.9 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain SAS4 PF15460.1 ESA00617.1 - 0.094 12.5 3.0 0.2 11.5 2.1 1.6 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 SIR2_2 PF13289.1 ESA00618.1 - 0.0074 16.1 0.2 0.0097 15.7 0.1 1.1 1 0 0 1 1 1 1 SIR2-like domain Sel1 PF08238.7 ESA00619.1 - 8.4e-211 677.8 95.5 3.3e-10 40.2 0.1 25.3 25 0 0 25 25 25 24 Sel1 repeat TPR_6 PF13174.1 ESA00619.1 - 2.9e-07 30.5 43.2 2.7 8.6 0.0 17.2 19 0 0 19 19 19 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA00619.1 - 0.00015 21.7 0.7 6 6.9 0.0 5.6 5 1 2 7 7 7 2 Influenza Matrix protein (M1) C-terminal domain Pkinase_Tyr PF07714.12 ESA00620.1 - 1.1e-37 129.5 0.0 2.6e-37 128.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00620.1 - 1.9e-35 122.2 0.1 3.4e-35 121.4 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA00620.1 - 0.00013 21.5 0.0 0.33 10.5 0.0 2.6 2 0 0 2 2 2 2 BCS1 N terminal zf-met PF12874.2 ESA00620.1 - 7.1 6.9 13.7 4 7.7 0.1 3.6 2 1 1 3 3 3 0 Zinc-finger of C2H2 type UEV PF05743.8 ESA00621.1 - 0.00073 19.2 4.4 0.31 10.7 0.1 4.1 5 0 0 5 5 5 2 UEV domain FYVE PF01363.16 ESA00621.1 - 0.0054 16.6 1.6 0.44 10.4 0.0 2.5 2 0 0 2 2 2 1 FYVE zinc finger Pyocin_S PF06958.7 ESA00621.1 - 0.046 14.0 1.4 29 5.0 0.0 4.6 5 0 0 5 5 5 0 S-type Pyocin Evr1_Alr PF04777.8 ESA00621.1 - 0.07 13.0 3.4 0.21 11.5 0.2 2.7 2 0 0 2 2 2 0 Erv1 / Alr family NOB1_Zn_bind PF08772.6 ESA00621.1 - 0.075 12.8 6.5 0.93 9.3 0.4 2.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like HSBP1 PF06825.7 ESA00621.1 - 0.091 12.3 5.5 27 4.4 0.0 4.7 5 0 0 5 5 5 0 Heat shock factor binding protein 1 DUF3534 PF12053.3 ESA00621.1 - 0.094 12.5 0.0 23 4.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3534) DnaJ_CXXCXGXG PF00684.14 ESA00621.1 - 1.3 9.1 10.7 8.3 6.5 2.6 2.3 2 0 0 2 2 2 0 DnaJ central domain Flu_NS2 PF00601.14 ESA00621.1 - 7.7 6.8 18.0 1 9.5 0.1 5.8 6 0 0 6 6 6 0 Influenza non-structural protein (NS2) AAA_33 PF13671.1 ESA00622.1 - 2.9e-24 85.5 0.0 1.4e-23 83.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA00622.1 - 5.1e-08 33.7 2.9 1.1e-07 32.6 1.2 2.1 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA00622.1 - 2e-07 31.3 3.9 1.2e-05 25.5 1.4 2.5 1 1 1 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA00622.1 - 3.5e-06 26.2 0.1 0.0031 16.6 0.0 2.2 1 1 1 2 2 2 2 Zeta toxin tRNA_lig_kinase PF08303.6 ESA00622.1 - 4e-06 26.7 0.9 1.1e-05 25.3 0.6 1.9 1 1 0 1 1 1 1 tRNA ligase kinase domain KTI12 PF08433.5 ESA00622.1 - 6.4e-06 25.5 3.9 0.0041 16.3 0.2 2.1 1 1 1 2 2 2 2 Chromatin associated protein KTI12 Thymidylate_kin PF02223.12 ESA00622.1 - 4.1e-05 23.0 0.3 0.42 9.9 0.0 3.1 3 0 0 3 3 3 2 Thymidylate kinase AAA_22 PF13401.1 ESA00622.1 - 0.00065 19.8 0.0 0.0011 19.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain CPT PF07931.7 ESA00622.1 - 0.002 17.7 0.1 0.83 9.2 0.0 2.1 1 1 1 2 2 2 2 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.13 ESA00622.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase 6PF2K PF01591.13 ESA00622.1 - 0.014 14.5 0.7 0.21 10.6 0.0 2.1 1 1 1 2 2 2 0 6-phosphofructo-2-kinase ADK PF00406.17 ESA00622.1 - 0.014 15.2 1.1 2.8 7.8 0.1 2.1 1 1 1 2 2 2 0 Adenylate kinase AAA_10 PF12846.2 ESA00622.1 - 0.02 14.3 0.0 0.072 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_16 PF13191.1 ESA00622.1 - 0.024 14.6 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 ESA00622.1 - 0.026 14.3 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESA00622.1 - 0.055 13.4 0.1 0.076 12.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 ESA00622.1 - 0.069 13.3 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MobB PF03205.9 ESA00622.1 - 0.081 12.6 0.2 0.21 11.2 0.1 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATP_bind_1 PF03029.12 ESA00622.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NACHT PF05729.7 ESA00622.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain Sec20 PF03908.8 ESA00623.1 - 0.039 13.6 1.2 0.049 13.3 0.8 1.2 1 0 0 1 1 1 0 Sec20 HAUS2 PF15003.1 ESA00623.1 - 0.068 12.2 1.5 0.066 12.2 1.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 Herpes_UL92 PF03048.9 ESA00624.1 - 0.38 10.3 4.3 1.9 8.0 0.0 3.4 3 1 1 4 4 4 0 UL92 family DUF3336 PF11815.3 ESA00625.1 - 1.6e-39 134.6 11.0 3.2e-39 133.7 7.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ESA00625.1 - 2.7e-21 76.4 0.0 2.3e-20 73.4 0.0 2.4 2 0 0 2 2 2 1 Patatin-like phospholipase Baculo_p24 PF05073.7 ESA00625.1 - 0.00078 19.0 2.8 0.002 17.7 1.9 1.6 1 0 0 1 1 1 1 Baculovirus P24 capsid protein zf-MYND PF01753.13 ESA00627.1 - 3.3e-08 33.2 17.1 8.6e-08 31.9 11.9 1.8 1 0 0 1 1 1 1 MYND finger DUF2950 PF11453.3 ESA00627.1 - 0.016 14.2 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) zf-Mss51 PF13824.1 ESA00627.1 - 0.72 9.7 7.8 1 9.2 4.6 1.9 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Nop10p PF04135.7 ESA00627.1 - 2.6 7.8 8.9 0.78 9.5 3.5 2.0 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family DNA_pol_B PF00136.16 ESA00628.1 - 4.9e-16 58.5 0.0 7.3e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESA00628.1 - 2e-07 30.2 0.1 3.6e-05 22.7 0.0 2.8 3 0 0 3 3 3 2 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.4 ESA00628.1 - 0.028 13.9 0.0 0.41 10.1 0.0 2.2 2 0 0 2 2 2 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_exo1 PF03104.14 ESA00629.1 - 5.6e-09 35.3 0.7 0.00042 19.2 0.0 2.9 2 1 0 2 2 2 2 DNA polymerase family B, exonuclease domain Prenyltrans_2 PF13249.1 ESA00631.1 - 1.3e-07 31.9 28.2 0.33 11.3 3.5 10.5 6 5 2 8 8 8 3 Prenyltransferase-like Prenyltrans PF00432.16 ESA00631.1 - 0.18 11.3 0.0 11 5.7 0.0 3.9 4 0 0 4 4 4 0 Prenyltransferase and squalene oxidase repeat HA PF03457.9 ESA00631.1 - 5.7 7.1 21.0 11 6.2 0.1 7.1 7 0 0 7 7 7 0 Helicase associated domain MSC PF09402.5 ESA00634.1 - 0.086 11.5 2.0 0.085 11.5 1.4 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain SHP PF03579.8 ESA00634.1 - 1.5 8.2 4.6 7.6 5.9 0.1 2.3 2 0 0 2 2 2 0 Small hydrophobic protein YABBY PF04690.8 ESA00635.1 - 2.6e-07 31.0 0.1 3e-07 30.8 0.1 1.0 1 0 0 1 1 1 1 YABBY protein DUF1014 PF06244.7 ESA00635.1 - 2e-06 27.9 0.5 2.4e-06 27.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) HMG_box PF00505.14 ESA00635.1 - 2e-05 24.7 0.2 2.1e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box Acyltransferase PF01553.16 ESA00636.1 - 6.7e-12 44.9 0.0 1.6e-10 40.5 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase CH PF00307.26 ESA00637.1 - 0.022 14.7 1.2 1.6 8.7 0.0 3.0 2 2 1 3 3 3 0 Calponin homology (CH) domain Sel1 PF08238.7 ESA00639.1 - 4.2e-56 186.1 21.3 7.7e-08 32.7 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA00639.1 - 0.19 12.2 13.8 34 5.1 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat MIT PF04212.13 ESA00639.1 - 0.27 11.1 6.8 8.3 6.3 0.6 4.1 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA00640.1 - 3.6e-114 370.7 43.5 4.3e-11 43.0 0.0 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_11 PF13414.1 ESA00640.1 - 0.00024 20.6 4.5 0.00024 20.6 3.1 5.6 4 2 2 6 6 6 2 TPR repeat TPR_12 PF13424.1 ESA00640.1 - 0.00037 20.3 8.9 0.0063 16.4 0.3 6.3 4 3 4 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00640.1 - 0.00046 20.7 1.2 0.17 12.6 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA00640.1 - 0.00054 19.4 1.3 0.00054 19.4 0.9 11.6 14 0 0 14 14 14 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00640.1 - 0.0023 18.2 21.0 0.21 12.1 0.0 8.2 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00640.1 - 0.0034 17.4 19.4 1.3 9.3 0.1 8.3 6 2 1 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00640.1 - 0.0034 17.1 0.9 0.0034 17.1 0.6 10.4 13 0 0 13 13 13 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA00640.1 - 0.042 13.7 0.3 0.042 13.7 0.2 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA00640.1 - 0.098 12.5 4.1 14 5.7 0.1 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TLD PF07534.11 ESA00641.1 - 0.012 15.6 0.3 0.014 15.3 0.2 1.1 1 0 0 1 1 1 0 TLD F-box-like PF12937.2 ESA00642.1 - 0.0074 15.9 1.0 0.016 14.9 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA00643.1 - 0.00085 18.9 0.8 0.0016 18.1 0.5 1.4 1 0 0 1 1 1 1 F-box-like Dimer_Tnp_hAT PF05699.9 ESA00644.1 - 3.2e-10 39.4 0.0 4e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Miro PF08477.8 ESA00645.1 - 0.0079 16.6 0.2 0.043 14.3 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein AAA_22 PF13401.1 ESA00645.1 - 0.021 14.9 4.7 0.04 14.0 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_5 PF07728.9 ESA00645.1 - 0.023 14.4 0.0 0.13 12.0 0.0 2.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA00645.1 - 0.068 13.3 0.0 0.068 13.3 0.0 3.5 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 ESA00646.1 - 1.9e-07 31.3 0.0 0.00047 20.3 0.0 3.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA00646.1 - 1.3e-05 24.8 0.0 0.024 14.3 0.0 4.2 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA00646.1 - 0.00027 20.8 0.0 0.0025 17.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA00646.1 - 0.00074 19.6 0.0 0.061 13.4 0.0 3.8 3 1 0 3 3 3 1 AAA domain NACHT PF05729.7 ESA00646.1 - 0.0019 17.9 0.0 0.32 10.6 0.0 3.1 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.1 ESA00646.1 - 0.0034 17.4 0.0 0.42 10.6 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain Miro PF08477.8 ESA00646.1 - 0.0099 16.3 0.0 0.071 13.6 0.0 2.6 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 ESA00646.1 - 0.01 15.8 0.0 1 9.3 0.0 3.7 5 0 0 5 5 5 0 AAA ATPase domain RNA_helicase PF00910.17 ESA00646.1 - 0.038 14.1 0.2 2.5 8.3 0.0 3.9 4 0 0 4 4 4 0 RNA helicase ABC_tran PF00005.22 ESA00646.1 - 0.071 13.4 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 ABC transporter Sel1 PF08238.7 ESA00648.1 - 1.7e-39 133.3 15.9 1.3e-13 51.1 0.6 5.2 5 0 0 5 5 5 5 Sel1 repeat TPR_16 PF13432.1 ESA00648.1 - 0.022 15.4 2.6 1.9 9.2 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PG_binding_2 PF08823.6 ESA00648.1 - 0.076 13.1 0.4 0.49 10.5 0.1 2.4 2 1 0 2 2 2 0 Putative peptidoglycan binding domain TPR_6 PF13174.1 ESA00648.1 - 0.74 10.4 10.4 11 6.6 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PCI PF01399.22 ESA00649.1 - 1.9e-13 50.6 0.1 1.9e-13 50.6 0.1 3.0 3 1 0 4 4 4 1 PCI domain Cytidylate_kin PF02224.13 ESA00649.1 - 0.019 14.4 1.2 0.038 13.4 0.8 1.6 1 0 0 1 1 1 0 Cytidylate kinase TPR_12 PF13424.1 ESA00649.1 - 0.44 10.5 12.8 0.35 10.8 3.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA00650.1 - 5e-09 35.7 0.0 2.5e-08 33.4 0.0 2.2 1 1 0 1 1 1 1 F-box-like F-box PF00646.28 ESA00650.1 - 0.0074 15.9 1.6 3.7 7.3 0.2 2.9 2 0 0 2 2 2 2 F-box domain DUF4014 PF13198.1 ESA00651.1 - 0.1 13.0 4.0 0.1 12.9 1.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4014) Tetraspannin PF00335.15 ESA00651.1 - 0.17 11.1 4.5 0.23 10.6 3.1 1.4 1 1 0 1 1 1 0 Tetraspanin family Peptidase_S9_N PF02897.10 ESA00652.1 - 7.1e-36 123.6 2.7 7e-30 103.9 0.8 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain p450 PF00067.17 ESA00653.1 - 2.6e-69 233.9 0.0 3.1e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA00654.1 - 8.6e-42 143.2 0.0 9.1e-42 143.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA00655.1 - 9.5e-15 54.0 0.1 1.1e-14 53.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA00656.1 - 2e-40 138.6 0.1 2.2e-40 138.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SopA PF13981.1 ESA00659.1 - 0.048 13.6 0.1 0.11 12.5 0.1 1.6 1 1 1 2 2 2 0 SopA-like central domain p450 PF00067.17 ESA00660.1 - 3.3e-54 184.1 0.2 3.8e-54 183.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Exo_endo_phos_2 PF14529.1 ESA00661.1 - 0.023 14.3 2.1 0.04 13.5 0.0 2.1 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Phage_int_SAM_3 PF14659.1 ESA00661.1 - 0.089 13.0 0.2 0.089 13.0 0.1 3.2 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain Gly_radical PF01228.16 ESA00662.1 - 0.071 13.4 0.1 0.32 11.3 0.0 1.9 1 1 1 2 2 2 0 Glycine radical Exo_endo_phos_2 PF14529.1 ESA00663.1 - 0.0052 16.3 0.0 0.0068 16.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase CENP-B_N PF04218.8 ESA00664.1 - 1.1e-11 43.9 0.1 1.7e-11 43.3 0.1 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain BrkDBD PF09607.5 ESA00664.1 - 1.2e-09 37.5 1.6 2.2e-09 36.7 0.5 1.9 1 1 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.15 ESA00664.1 - 3.7e-07 30.0 0.4 5.5e-07 29.4 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.1 ESA00664.1 - 0.00013 21.9 0.1 0.00038 20.3 0.0 1.8 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA00664.1 - 0.00028 20.4 0.1 0.00057 19.4 0.0 1.6 1 1 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 ESA00664.1 - 0.052 13.2 0.3 0.13 11.9 0.0 1.7 1 1 1 2 2 2 0 Transposase DUF1648 PF07853.6 ESA00665.1 - 0.13 11.8 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) Pkinase_Tyr PF07714.12 ESA00667.1 - 5.2e-12 45.3 0.0 8.4e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00667.1 - 2.1e-09 36.9 0.0 4.5e-09 35.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain DUF2975 PF11188.3 ESA00669.1 - 0.077 12.7 0.5 0.082 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) VWA_3 PF13768.1 ESA00670.1 - 5.4e-25 87.8 0.0 8.1e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA00670.1 - 1.2e-08 35.2 0.0 1.9e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA00670.1 - 1.3e-08 34.8 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 ESA00670.1 - 0.0015 18.3 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus Luciferase_N PF05295.6 ESA00670.1 - 0.01 15.6 0.2 0.022 14.5 0.2 1.5 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain Sel1 PF08238.7 ESA00671.1 - 1.2e-222 715.4 72.5 8.1e-10 39.0 0.0 26.1 25 1 1 26 26 26 26 Sel1 repeat TPR_17 PF13431.1 ESA00671.1 - 2.1e-11 43.0 38.3 31 5.1 0.0 19.7 19 2 3 22 22 22 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00671.1 - 1.1e-05 25.5 58.6 3.6 8.2 0.0 19.1 24 0 0 24 24 24 3 Tetratricopeptide repeat Colicin_immun PF09204.5 ESA00671.1 - 0.00013 21.9 22.8 14 5.8 0.0 10.5 7 5 5 12 12 12 1 Bacterial self-protective colicin-like immunity SnoaL_3 PF13474.1 ESA00671.1 - 0.0054 16.7 12.1 25 4.9 0.0 8.9 10 1 1 11 11 11 0 SnoaL-like domain Phage_terminase PF10668.4 ESA00671.1 - 0.024 14.4 65.1 6.7 6.5 0.1 18.6 17 4 6 23 23 23 0 Phage terminase small subunit HTH_16 PF12645.2 ESA00671.1 - 0.16 11.9 64.4 7.6 6.5 0.0 16.8 20 1 0 20 20 20 0 Helix-turn-helix domain LEA_5 PF00477.12 ESA00671.1 - 0.16 12.2 18.5 7.7 6.8 0.0 7.6 5 3 3 8 8 8 0 Small hydrophilic plant seed protein FlhC PF05280.6 ESA00671.1 - 0.22 10.9 15.9 19 4.6 0.0 10.0 9 5 7 16 16 16 0 Flagellar transcriptional activator (FlhC) Sel1 PF08238.7 ESA00672.1 - 2.1e-71 234.7 34.0 4.5e-10 39.8 0.2 8.8 8 1 1 9 9 9 8 Sel1 repeat TPR_6 PF13174.1 ESA00672.1 - 1.4e-05 25.2 18.8 1.7 9.2 0.1 6.7 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00672.1 - 0.00017 21.5 15.9 35 4.9 0.0 7.8 7 1 0 7 7 7 0 Tetratricopeptide repeat DUF2930 PF11152.3 ESA00672.1 - 0.14 11.2 0.1 11 5.1 0.0 3.1 1 1 2 4 4 4 0 Protein of unknown function (DUF2930) Phage_terminase PF10668.4 ESA00672.1 - 2.6 7.9 15.0 29 4.5 0.0 6.6 6 2 2 8 8 8 0 Phage terminase small subunit Filament PF00038.16 ESA00674.1 - 2.6e-05 23.8 24.1 0.00083 18.9 5.3 2.3 1 1 1 2 2 2 2 Intermediate filament protein EzrA PF06160.7 ESA00674.1 - 3.5e-05 22.1 21.9 0.00011 20.5 13.7 2.1 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA Bacillus_HBL PF05791.6 ESA00674.1 - 0.00015 21.1 21.1 0.0035 16.7 6.9 2.1 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) Syntaxin-6_N PF09177.6 ESA00674.1 - 0.00045 20.5 18.4 0.023 15.0 0.3 3.6 2 1 2 4 4 4 1 Syntaxin 6, N-terminal IncA PF04156.9 ESA00674.1 - 0.00055 19.5 26.3 0.0014 18.2 7.8 2.2 1 1 1 2 2 2 2 IncA protein HOOK PF05622.7 ESA00674.1 - 0.00058 17.8 25.0 0.00074 17.4 17.3 1.0 1 0 0 1 1 1 1 HOOK protein ADIP PF11559.3 ESA00674.1 - 0.0028 17.5 30.9 0.014 15.3 8.7 3.1 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding DUF869 PF05911.6 ESA00674.1 - 0.003 15.8 21.6 0.0043 15.3 14.9 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) Myosin_tail_1 PF01576.14 ESA00674.1 - 0.0051 14.6 30.4 0.034 11.8 14.7 1.6 1 1 0 1 1 1 1 Myosin tail TPR_MLP1_2 PF07926.7 ESA00674.1 - 0.0058 16.3 32.4 0.35 10.6 16.2 2.8 1 1 0 2 2 2 2 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.5 ESA00674.1 - 0.0061 16.6 21.3 0.011 15.9 10.3 2.3 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family ATG16 PF08614.6 ESA00674.1 - 0.0064 16.3 32.5 0.016 15.0 8.8 3.1 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 ESA00674.1 - 0.0069 16.1 28.3 0.014 15.1 11.3 2.9 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF3584 PF12128.3 ESA00674.1 - 0.0071 13.7 27.6 0.038 11.3 12.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) SlyX PF04102.7 ESA00674.1 - 0.0087 16.4 22.8 0.015 15.6 0.7 3.5 1 1 1 3 3 3 1 SlyX Rootletin PF15035.1 ESA00674.1 - 0.009 16.0 4.5 0.009 16.0 3.1 2.4 1 1 2 3 3 3 1 Ciliary rootlet component, centrosome cohesion DUF4200 PF13863.1 ESA00674.1 - 0.0098 15.8 31.5 0.038 13.9 11.4 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF4200) WEMBL PF05701.6 ESA00674.1 - 0.013 14.0 25.2 0.023 13.1 17.4 1.4 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 ESA00674.1 - 0.013 14.6 6.3 0.026 13.7 2.9 1.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Spc7 PF08317.6 ESA00674.1 - 0.018 13.7 30.9 0.014 14.0 11.4 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Mga PF05043.8 ESA00674.1 - 0.024 14.9 8.1 0.49 10.7 2.0 2.4 2 0 0 2 2 2 0 Mga helix-turn-helix domain AATF-Che1 PF13339.1 ESA00674.1 - 0.026 14.6 19.5 0.03 14.4 5.8 2.3 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor FliJ PF02050.11 ESA00674.1 - 0.036 14.1 20.4 0.026 14.5 2.9 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein HR1 PF02185.11 ESA00674.1 - 0.038 13.7 13.9 2.5 7.9 1.7 2.9 1 1 1 2 2 2 0 Hr1 repeat DUF641 PF04859.7 ESA00674.1 - 0.05 13.3 20.8 0.19 11.5 4.4 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF3391 PF11871.3 ESA00674.1 - 0.071 13.3 13.3 3.3 7.9 2.5 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3391) GrpE PF01025.14 ESA00674.1 - 0.079 12.4 27.1 0.42 10.1 3.7 3.2 1 1 1 3 3 3 0 GrpE Fez1 PF06818.10 ESA00674.1 - 0.11 12.5 21.8 0.14 12.1 11.6 2.2 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.7 ESA00674.1 - 0.11 12.3 15.6 0.065 13.0 3.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Tektin PF03148.9 ESA00674.1 - 0.12 10.9 21.9 0.12 10.9 2.4 2.9 1 1 1 2 2 2 0 Tektin family TMF_DNA_bd PF12329.3 ESA00674.1 - 0.14 11.9 37.7 0.28 11.0 2.3 4.7 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding RNase_H PF00075.19 ESA00674.1 - 0.14 12.5 6.4 0.17 12.2 4.0 1.5 1 1 0 1 1 1 0 RNase H DUF342 PF03961.8 ESA00674.1 - 0.14 10.5 25.8 0.028 12.8 10.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Mod_r PF07200.8 ESA00674.1 - 0.17 11.8 26.5 2.7 7.8 1.8 3.0 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TACC PF05010.9 ESA00674.1 - 0.2 11.4 21.8 0.3 10.8 15.1 1.4 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) ISG65-75 PF11727.3 ESA00674.1 - 0.22 10.5 18.8 0.085 11.8 6.5 2.1 1 1 1 2 2 2 0 Invariant surface glycoprotein WXG100 PF06013.7 ESA00674.1 - 0.23 11.4 10.8 3.5 7.6 3.8 3.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG DUF211 PF02680.9 ESA00674.1 - 0.25 11.1 2.7 8.1 6.3 0.3 2.6 1 1 2 3 3 3 0 Uncharacterized ArCR, COG1888 MCPsignal PF00015.16 ESA00674.1 - 0.26 10.8 12.8 0.69 9.4 8.2 1.9 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PspA_IM30 PF04012.7 ESA00674.1 - 0.28 10.4 22.5 0.17 11.2 7.8 2.6 1 1 1 2 2 2 0 PspA/IM30 family APG17 PF04108.7 ESA00674.1 - 0.29 9.8 21.2 0.73 8.5 1.9 2.4 1 1 1 2 2 2 0 Autophagy protein Apg17 Serine_rich PF08824.5 ESA00674.1 - 0.33 10.6 7.0 0.32 10.7 4.2 1.5 1 1 0 1 1 1 0 Serine rich protein interaction domain Atg14 PF10186.4 ESA00674.1 - 0.34 9.8 27.3 1.8 7.4 11.0 2.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF2265 PF10023.4 ESA00674.1 - 0.36 9.9 8.9 0.47 9.5 6.2 1.1 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) Laminin_II PF06009.7 ESA00674.1 - 0.41 10.3 19.7 0.26 11.0 6.7 2.5 1 1 2 3 3 3 0 Laminin Domain II HlyD PF00529.15 ESA00674.1 - 0.48 9.6 17.0 1.9 7.6 11.7 1.9 1 1 0 1 1 1 0 HlyD family secretion protein NPV_P10 PF05531.7 ESA00674.1 - 0.53 10.5 13.2 3 8.1 0.6 3.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF2935 PF11155.3 ESA00674.1 - 0.54 10.3 13.8 0.91 9.6 5.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) IFT57 PF10498.4 ESA00674.1 - 0.58 8.8 27.8 0.28 9.8 9.0 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Baculo_PEP_C PF04513.7 ESA00674.1 - 0.65 9.8 9.3 0.82 9.4 0.9 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc42p PF11544.3 ESA00674.1 - 0.67 9.9 22.9 2.4 8.1 6.5 4.0 2 1 1 3 3 3 0 Spindle pole body component Spc42p Tropomyosin_1 PF12718.2 ESA00674.1 - 0.71 9.7 36.0 3 7.6 15.9 2.8 1 1 1 2 2 2 0 Tropomyosin like GAS PF13851.1 ESA00674.1 - 0.76 8.9 34.0 0.84 8.8 11.5 2.5 2 1 1 3 3 2 0 Growth-arrest specific micro-tubule binding Bap31 PF05529.7 ESA00674.1 - 1 8.7 23.3 0.57 9.6 3.7 3.2 1 1 2 3 3 3 0 B-cell receptor-associated protein 31-like DUF724 PF05266.9 ESA00674.1 - 1 8.9 28.5 2.4 7.7 5.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF2015 PF09435.5 ESA00674.1 - 1.1 9.0 6.0 0.41 10.4 0.8 2.2 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) COG5 PF10392.4 ESA00674.1 - 1.1 9.2 14.3 0.87 9.5 3.1 2.9 1 1 2 3 3 3 0 Golgi transport complex subunit 5 HET PF06985.6 ESA00674.1 - 1.3 9.1 8.8 7.9 6.6 5.6 2.3 1 1 0 1 1 1 0 Heterokaryon incompatibility protein (HET) DUF1759 PF03564.10 ESA00674.1 - 1.5 8.5 14.2 8.4 6.1 0.5 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) COOH-NH2_lig PF14395.1 ESA00674.1 - 1.6 7.7 5.7 0.92 8.5 2.0 1.8 1 1 1 2 2 2 0 Phage phiEco32-like COOH.NH2 ligase-type 2 ALMT PF11744.3 ESA00674.1 - 2.1 6.9 8.8 2.8 6.5 6.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.1 ESA00674.1 - 2.1 7.2 22.4 1.9 7.3 13.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF745 PF05335.8 ESA00674.1 - 2.3 7.6 19.4 0.22 11.0 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) APG6 PF04111.7 ESA00674.1 - 2.6 7.0 29.6 0.13 11.3 13.3 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Spc24 PF08286.6 ESA00674.1 - 2.8 7.6 29.6 3 7.5 4.2 3.3 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 ERM PF00769.14 ESA00674.1 - 3.1 7.2 30.2 1.6 8.1 1.4 2.5 1 1 0 2 2 2 0 Ezrin/radixin/moesin family AcylCoA_dehyd_C PF12186.3 ESA00674.1 - 3.1 7.6 9.9 0.16 11.8 0.9 2.8 1 1 2 3 3 3 0 Acyl-CoA dehydrogenase C terminal DUF883 PF05957.8 ESA00674.1 - 3.2 8.2 12.5 2.5 8.5 2.8 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) FlxA PF14282.1 ESA00674.1 - 3.7 7.5 30.0 0.43 10.5 13.7 2.8 1 1 0 2 2 2 0 FlxA-like protein DivIC PF04977.10 ESA00674.1 - 3.7 7.1 35.0 0.12 11.8 1.7 5.1 2 2 2 5 5 5 0 Septum formation initiator DUF489 PF04356.7 ESA00674.1 - 3.8 7.0 13.0 1.2 8.7 4.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Cytochrom_B562 PF07361.6 ESA00674.1 - 3.8 7.9 18.9 0.77 10.1 8.1 2.4 1 1 1 2 2 2 0 Cytochrome b562 Sec2p PF06428.6 ESA00674.1 - 3.9 7.3 28.4 1.5 8.7 2.0 3.4 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p YlqD PF11068.3 ESA00674.1 - 3.9 7.5 27.8 4.1 7.4 1.7 3.1 1 1 2 3 3 3 0 YlqD protein TcdB_N PF12918.2 ESA00674.1 - 4.7 7.3 13.1 0.52 10.4 1.2 3.4 3 1 1 4 4 2 0 TcdB toxin N-terminal helical domain AKNA PF12443.3 ESA00674.1 - 5.2 7.1 15.8 0.39 10.7 0.9 3.1 1 1 2 3 3 3 0 AT-hook-containing transcription factor FAD-SLDH PF12318.3 ESA00674.1 - 5.5 6.6 7.7 3.6 7.2 1.4 2.3 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF4618 PF15397.1 ESA00674.1 - 5.6 6.2 25.8 5.6 6.2 6.6 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) Prefoldin_2 PF01920.15 ESA00674.1 - 5.6 6.7 33.4 1.7 8.4 0.6 4.4 1 1 3 4 4 4 0 Prefoldin subunit Ax_dynein_light PF10211.4 ESA00674.1 - 5.8 6.6 33.8 2.5 7.9 4.8 3.2 1 1 2 3 3 3 0 Axonemal dynein light chain DUF1796 PF08795.5 ESA00674.1 - 6 6.4 7.4 1.4 8.5 0.5 2.3 1 1 1 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) DUF972 PF06156.8 ESA00674.1 - 6.3 7.2 25.9 8 6.8 6.3 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Lumazine_bd PF12870.2 ESA00674.1 - 6.5 6.8 18.7 27 4.8 2.5 2.3 1 1 1 2 2 2 0 Lumazine-binding domain She9_MDM33 PF05546.6 ESA00674.1 - 6.9 6.1 20.0 0.26 10.8 2.2 2.8 1 1 2 3 3 3 0 She9 / Mdm33 family DUF2968 PF11180.3 ESA00674.1 - 7.2 5.9 21.2 2.7 7.3 5.4 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF2968) CENP-Q PF13094.1 ESA00674.1 - 7.2 6.6 28.0 9.4 6.2 8.2 2.7 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Tweety PF04906.8 ESA00674.1 - 8.1 4.7 9.0 0.42 8.9 0.3 2.0 1 1 1 2 2 2 0 Tweety Nup54 PF13874.1 ESA00674.1 - 8.4 6.0 20.8 3.6 7.2 2.2 2.4 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF3450 PF11932.3 ESA00674.1 - 8.4 5.5 23.5 0.6 9.3 2.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.17 ESA00674.1 - 8.7 6.4 30.2 8.6 6.4 10.0 3.2 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF2730 PF10805.3 ESA00674.1 - 8.7 6.1 15.3 8.4 6.1 3.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Phage_GP20 PF06810.6 ESA00674.1 - 9.9 5.5 35.1 1.8 8.0 4.1 3.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 FYDLN_acid PF09538.5 ESA00676.1 - 0.81 10.2 5.8 1.2 9.7 4.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PRA-PH PF01503.12 ESA00676.1 - 0.83 9.9 4.5 0.47 10.7 1.5 1.7 1 1 1 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase Cas_Cas02710 PF09670.5 ESA00677.1 - 0.061 11.9 0.1 0.065 11.8 0.1 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) Myb_DNA-bind_4 PF13837.1 ESA00682.1 - 2.6e-10 40.3 4.7 6.1e-10 39.1 3.3 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA00682.1 - 0.012 16.2 3.1 0.012 16.2 2.2 2.2 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain RNA_pol_Rpb5_N PF03871.9 ESA00682.1 - 0.037 14.4 3.0 1.1 9.7 0.1 2.7 2 1 1 3 3 3 0 RNA polymerase Rpb5, N-terminal domain IDO PF01231.13 ESA00684.1 - 0.061 11.7 0.1 0.067 11.6 0.1 1.0 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase PDEase_II PF02112.10 ESA00685.1 - 0.074 11.9 0.1 0.09 11.6 0.1 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II AMP-binding PF00501.23 ESA00686.1 - 0.00012 20.6 0.0 0.00013 20.4 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Picorna_P3A PF06363.6 ESA00687.1 - 0.26 11.2 3.3 5.9 6.9 0.0 3.2 2 1 0 3 3 3 0 Picornaviridae P3A protein 4HB_MCP_1 PF12729.2 ESA00687.1 - 4.9 6.4 9.3 0.36 10.1 2.8 1.7 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction ubiquitin PF00240.18 ESA00689.1 - 7.4e-10 38.0 0.2 1e-09 37.6 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA00689.1 - 0.0013 18.3 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad50_zn_hook PF04423.9 ESA00690.1 - 0.055 12.9 1.1 0.055 12.9 0.8 3.2 4 0 0 4 4 4 0 Rad50 zinc hook motif Endonuclease_7 PF02945.10 ESA00690.1 - 0.087 12.5 0.4 0.18 11.5 0.3 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII DUF2235 PF09994.4 ESA00691.1 - 2.7e-23 82.7 0.0 3e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ESA00691.1 - 0.071 12.8 0.0 0.083 12.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Porin_O_P PF07396.6 ESA00691.1 - 0.084 11.7 0.0 0.084 11.7 0.0 1.0 1 0 0 1 1 1 0 Phosphate-selective porin O and P Lipocalin_4 PF13648.1 ESA00692.1 - 1.4 9.6 7.3 2.3 8.8 5.0 1.3 1 1 0 1 1 1 0 Lipocalin-like domain Lipase_3 PF01764.20 ESA00693.1 - 1.9e-17 63.1 0.0 3.5e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESA00693.1 - 0.011 15.6 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.9 ESA00693.1 - 0.02 14.1 0.1 0.068 12.4 0.0 1.8 2 0 0 2 2 2 0 Putative serine esterase (DUF676) PGAP1 PF07819.8 ESA00693.1 - 0.023 14.3 0.1 0.039 13.5 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.8 ESA00693.1 - 0.076 12.5 0.0 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF2305 PF10230.4 ESA00693.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) PI31_Prot_N PF11566.3 ESA00694.1 - 0.043 13.4 1.7 0.06 12.9 1.2 1.3 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal DUF1084 PF06454.6 ESA00694.1 - 0.077 12.0 0.3 0.12 11.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1084) MIR PF02815.14 ESA00697.1 - 9.3e-07 28.5 0.1 0.016 14.7 0.0 2.5 1 1 1 2 2 2 2 MIR domain DUF2115 PF09888.4 ESA00697.1 - 0.053 13.6 0.5 0.053 13.6 0.4 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DUF106 PF01956.11 ESA00699.1 - 0.011 15.2 3.2 0.015 14.8 2.2 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF3942 PF13078.1 ESA00699.1 - 0.029 14.4 8.7 0.13 12.3 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3942) CDC37_N PF03234.9 ESA00699.1 - 0.26 11.6 12.9 0.08 13.2 4.5 2.0 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Aida_N PF08910.5 ESA00699.1 - 3.9 7.7 6.8 65 3.8 4.7 2.5 1 1 0 1 1 1 0 Aida N-terminus AAA_23 PF13476.1 ESA00699.1 - 5.3 7.3 17.6 6.6 7.0 12.2 1.1 1 0 0 1 1 1 0 AAA domain PhoU PF01895.14 ESA00699.1 - 6.3 7.3 10.7 1.1 9.7 2.3 2.2 1 1 1 2 2 2 0 PhoU domain Nucleoplasmin PF03066.10 ESA00700.1 - 0.29 10.6 4.8 0.29 10.6 3.3 1.1 1 0 0 1 1 1 0 Nucleoplasmin PH PF00169.24 ESA00702.1 - 9e-11 41.9 3.6 9e-11 41.9 2.5 2.6 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 ESA00702.1 - 0.0064 16.7 4.7 0.29 11.3 3.2 3.3 1 1 0 1 1 1 1 Pleckstrin homology domain Peptidase_S8 PF00082.17 ESA00703.1 - 2.4e-40 138.4 12.3 3.6e-40 137.9 8.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA00703.1 - 0.023 15.2 0.0 0.049 14.1 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 Pkinase_Tyr PF07714.12 ESA00704.1 - 6.2e-37 127.0 0.0 7.7e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00704.1 - 5.9e-31 107.5 0.0 7.7e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA00704.1 - 0.00019 20.5 0.2 0.00026 20.0 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA00704.1 - 0.00088 18.3 0.0 0.0012 17.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA00704.1 - 0.064 12.9 0.2 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S8 PF00082.17 ESA00705.1 - 6.9e-39 133.6 8.4 1.4e-38 132.6 5.7 1.5 2 0 0 2 2 2 1 Subtilase family MULE PF10551.4 ESA00706.1 - 0.017 15.2 0.1 0.27 11.4 0.0 2.2 2 0 0 2 2 2 0 MULE transposase domain ACP PF06857.6 ESA00706.1 - 0.097 12.5 0.1 2 8.3 0.0 2.2 2 0 0 2 2 2 0 Malonate decarboxylase delta subunit (MdcD) DUF4030 PF13222.1 ESA00706.1 - 0.12 12.0 0.5 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4030) HMG_box PF00505.14 ESA00709.1 - 0.012 15.8 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box Pkinase PF00069.20 ESA00710.1 - 2.1e-20 73.0 0.0 3.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00710.1 - 7.6e-20 71.0 0.0 1.1e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SYCE1 PF15233.1 ESA00710.1 - 0.03 14.2 0.1 0.048 13.5 0.0 1.5 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 Vg_Tdu PF07545.9 ESA00711.1 - 0.06 12.7 0.2 0.58 9.6 0.0 2.1 2 0 0 2 2 2 0 Vestigial/Tondu family PPR_2 PF13041.1 ESA00712.1 - 1.4e-40 137.0 14.6 2.1e-11 43.5 0.0 9.7 4 2 6 10 10 10 8 PPR repeat family PPR PF01535.15 ESA00712.1 - 3.1e-28 95.7 24.3 1.2e-05 24.8 0.0 11.1 12 1 0 12 12 12 6 PPR repeat PPR_3 PF13812.1 ESA00712.1 - 4.1e-25 85.9 0.2 0.00046 20.2 0.0 8.4 9 1 1 10 10 9 5 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA00712.1 - 1.9e-12 46.4 7.5 0.022 14.2 0.0 7.8 8 1 0 8 8 8 4 PPR repeat TPR_2 PF07719.12 ESA00712.1 - 0.001 18.8 0.7 19 5.5 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00712.1 - 0.0044 16.6 9.3 2.2 8.2 0.1 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00712.1 - 0.027 14.7 0.1 2.8 8.3 0.0 3.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00712.1 - 0.037 13.9 1.6 6.5 6.7 0.1 4.2 5 1 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA00712.1 - 0.043 13.9 2.3 3.9 7.6 0.0 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 ESA00712.1 - 0.063 13.5 0.1 5.4 7.3 0.0 2.9 3 0 0 3 3 3 0 Bacterial transcriptional activator domain Ribonuc_red_lgN PF00317.16 ESA00712.1 - 0.092 12.5 1.5 0.65 9.8 0.1 3.1 2 2 0 2 2 2 0 Ribonucleotide reductase, all-alpha domain SPOB_a PF14689.1 ESA00712.1 - 0.18 11.3 2.0 4.1 7.0 0.0 3.4 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain ECSIT PF06239.6 ESA00712.1 - 0.22 10.3 3.3 1.9 7.2 0.2 3.4 1 1 1 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway AD PF09793.4 ESA00713.1 - 6.9e-25 86.7 0.0 1.7e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain Gemin6 PF06372.7 ESA00713.1 - 0.023 14.0 0.0 1.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Gemin6 protein LSM PF01423.17 ESA00713.1 - 0.027 14.0 0.0 0.062 12.8 0.0 1.6 1 0 0 1 1 1 0 LSM domain YmzC PF14157.1 ESA00713.1 - 1.4 8.8 8.4 0.048 13.4 1.0 2.1 2 1 0 2 2 2 0 YmzC-like protein Metallophos_2 PF12850.2 ESA00714.1 - 2.5e-17 63.1 0.0 3.3e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 ESA00714.1 - 7.2e-06 25.5 1.8 0.035 13.4 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase PPR_2 PF13041.1 ESA00715.1 - 3.2e-55 183.8 20.1 1.2e-08 34.8 0.0 12.9 7 2 7 14 14 14 11 PPR repeat family PPR PF01535.15 ESA00715.1 - 1.2e-45 150.2 8.5 8.6e-06 25.3 0.0 11.5 11 0 0 11 11 11 9 PPR repeat PPR_1 PF12854.2 ESA00715.1 - 2.1e-41 139.0 3.2 1.6e-07 30.6 0.0 10.2 10 0 0 10 10 10 8 PPR repeat PPR_3 PF13812.1 ESA00715.1 - 8.6e-41 134.8 0.0 0.0075 16.4 0.1 11.4 12 0 0 12 12 12 9 Pentatricopeptide repeat domain TPR_7 PF13176.1 ESA00715.1 - 1.7e-05 24.2 0.7 57 3.8 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00715.1 - 2.9e-05 24.3 0.0 11 6.5 0.0 5.7 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00715.1 - 3.2e-05 24.1 0.0 36 5.3 0.0 6.8 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00715.1 - 0.00041 20.9 0.0 27 5.6 0.0 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00715.1 - 0.013 15.3 2.9 11 6.1 0.0 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00715.1 - 0.061 13.8 3.2 45 4.8 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA00715.1 - 0.21 11.5 0.9 71 3.5 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribonuc_red_lgC PF02867.10 ESA00716.1 - 4.7e-08 32.0 0.0 0.015 13.8 0.0 3.6 3 0 0 3 3 3 3 Ribonucleotide reductase, barrel domain Proteasome PF00227.21 ESA00717.1 - 2.6e-48 163.8 0.1 3.2e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF4522 PF15022.1 ESA00719.1 - 0.017 14.8 0.5 0.21 11.3 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4522) CCDC-167 PF15188.1 ESA00719.1 - 0.067 13.1 3.7 0.13 12.2 2.6 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Hc1 PF07432.8 ESA00719.1 - 0.1 12.7 0.2 0.15 12.2 0.2 1.2 1 0 0 1 1 1 0 Histone H1-like protein Hc1 HTH_Tnp_Tc3_2 PF01498.13 ESA00720.1 - 0.0098 15.9 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 Transposase EphA2_TM PF14575.1 ESA00721.1 - 0.0088 16.4 0.1 0.83 10.0 0.0 2.5 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.5 ESA00721.1 - 0.049 12.9 0.2 0.049 12.9 0.1 1.9 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF1345 PF07077.6 ESA00724.1 - 0.52 9.7 2.8 0.83 9.1 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) ABC2_membrane_3 PF12698.2 ESA00724.1 - 0.81 8.6 15.4 0.039 12.9 4.8 1.9 1 1 1 2 2 2 0 ABC-2 family transporter protein Aldedh PF00171.17 ESA00726.1 - 1.5e-62 211.4 0.2 1.4e-53 181.8 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family eIF_4EBP PF05456.6 ESA00727.1 - 1.3e-24 86.1 1.7 1.4e-24 86.0 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) CRAL_TRIO PF00650.15 ESA00728.1 - 1.9e-37 128.1 0.1 2.8e-37 127.6 0.1 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESA00728.1 - 1.6e-13 50.5 2.2 3.5e-13 49.4 1.5 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESA00728.1 - 0.0091 15.9 0.0 0.024 14.5 0.0 1.7 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain Rho_GDI PF02115.12 ESA00730.1 - 5.4e-67 225.0 1.5 5.9e-67 224.9 1.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor SNARE PF05739.14 ESA00731.1 - 3.3e-06 26.6 0.3 5.7e-06 25.9 0.2 1.3 1 0 0 1 1 1 1 SNARE domain DUF202 PF02656.10 ESA00731.1 - 0.0081 16.3 0.1 0.011 15.9 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF202) DUF3437 PF11919.3 ESA00732.1 - 3.3e-38 129.2 0.1 4.7e-36 122.3 0.0 3.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT_2 PF13646.1 ESA00732.1 - 2.1e-06 27.9 0.0 0.0014 18.9 0.0 4.2 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.17 ESA00732.1 - 0.00047 20.0 0.5 6.1 7.1 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat DUF3677 PF12432.3 ESA00732.1 - 0.015 15.7 0.4 0.071 13.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) Cnd1 PF12717.2 ESA00732.1 - 0.049 13.4 5.2 4.8 6.9 0.0 4.0 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Interferon PF00143.14 ESA00732.1 - 0.076 12.8 4.1 0.039 13.8 0.8 2.0 2 0 0 2 2 2 0 Interferon alpha/beta domain DUF869 PF05911.6 ESA00733.1 - 0.00039 18.8 31.7 0.00039 18.8 22.0 2.4 1 1 1 2 2 2 1 Plant protein of unknown function (DUF869) MtrG PF04210.8 ESA00733.1 - 1.3 8.7 6.1 0.31 10.7 0.2 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G UCR_TM PF02921.9 ESA00735.1 - 1.3e-17 63.7 1.5 2.8e-17 62.6 1.1 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.21 ESA00735.1 - 4.6e-17 61.3 0.1 7.4e-17 60.7 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain GASA PF02704.9 ESA00735.1 - 0.11 12.5 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 Gibberellin regulated protein DUF2516 PF10724.4 ESA00735.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2516) NRDE-2 PF08424.5 ESA00736.1 - 3e-72 243.2 5.3 3.6e-66 223.2 0.1 4.1 3 1 0 3 3 3 3 NRDE-2, necessary for RNA interference TPR_14 PF13428.1 ESA00736.1 - 8.9e-08 32.1 0.0 1.9 9.3 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00736.1 - 0.00025 21.3 1.2 4.7 7.6 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESA00736.1 - 0.0018 17.3 0.0 0.0082 15.2 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00736.1 - 0.08 13.1 3.2 8 6.9 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1183 PF06682.7 ESA00737.1 - 8.4e-05 22.3 0.1 0.00013 21.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) TMEM51 PF15345.1 ESA00737.1 - 0.007 16.0 0.0 0.0089 15.7 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 Shisa PF13908.1 ESA00737.1 - 0.015 15.5 0.7 0.052 13.7 0.5 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4234 PF14018.1 ESA00737.1 - 0.062 13.0 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) mRNA_cap_enzyme PF01331.14 ESA00738.1 - 2.8e-27 95.6 0.1 3.6e-27 95.3 0.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.16 ESA00738.1 - 0.001 18.4 0.4 0.4 10.0 0.0 2.6 1 1 1 2 2 2 2 ATP dependent DNA ligase domain mRNA_cap_enzyme PF01331.14 ESA00739.1 - 0.00052 19.7 0.0 0.0017 18.1 0.0 1.9 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 ESA00739.1 - 0.0086 16.3 0.2 0.0086 16.3 0.2 3.5 3 1 0 3 3 3 1 mRNA capping enzyme, C-terminal domain LHC PF00556.15 ESA00740.1 - 0.48 10.3 2.4 0.69 9.8 0.6 1.9 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit TPR_11 PF13414.1 ESA00743.1 - 1.3e-34 117.6 23.0 2e-14 52.9 0.1 5.9 3 2 1 6 6 6 5 TPR repeat TPR_2 PF07719.12 ESA00743.1 - 5.5e-32 107.0 19.5 3.5e-07 29.6 0.0 8.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESA00743.1 - 1.3e-27 94.1 32.7 6.1e-09 35.1 0.0 8.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00743.1 - 2e-24 83.5 28.5 3e-08 32.8 0.0 7.7 7 1 1 8 8 7 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00743.1 - 4.4e-17 62.2 0.0 1.7e-06 28.5 0.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00743.1 - 5.4e-16 58.3 10.7 0.00021 21.1 0.3 5.8 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00743.1 - 1.3e-13 49.9 22.5 0.0042 17.1 0.1 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00743.1 - 2e-12 46.5 0.0 0.45 11.2 0.0 6.4 2 2 5 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00743.1 - 2.6e-11 43.6 1.4 0.0035 17.6 0.1 5.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00743.1 - 9.7e-11 41.4 0.1 0.0032 17.8 0.0 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA00743.1 - 1e-10 40.5 8.6 0.057 13.2 0.0 7.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA00743.1 - 5.3e-10 39.0 0.0 9.4e-07 28.6 0.0 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat NARP1 PF12569.3 ESA00743.1 - 0.0002 20.2 0.2 0.31 9.7 0.0 2.5 2 1 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_15 PF13429.1 ESA00743.1 - 0.0008 18.5 0.0 1.9 7.5 0.0 3.0 2 1 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA00743.1 - 0.0019 18.0 13.5 0.52 10.2 0.0 7.0 6 1 1 7 7 7 1 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.4 ESA00743.1 - 0.0049 16.0 0.2 3.7 6.8 0.0 4.5 5 0 0 5 5 5 1 SHNi-TPR TPR_10 PF13374.1 ESA00743.1 - 0.02 14.8 3.7 16 5.5 0.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.12 ESA00743.1 - 0.077 13.2 0.0 0.17 12.2 0.0 1.5 2 0 0 2 2 1 0 Bacterial transcriptional activator domain Pkinase_Tyr PF07714.12 ESA00744.1 - 8.2e-49 165.9 0.1 1.4e-48 165.2 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00744.1 - 9.1e-48 162.6 1.5 2.1e-47 161.4 1.1 1.6 1 0 0 1 1 1 1 Protein kinase domain TPR_11 PF13414.1 ESA00744.1 - 8.5e-31 105.4 31.4 6.5e-12 44.9 0.2 6.2 4 1 2 7 7 6 5 TPR repeat TPR_2 PF07719.12 ESA00744.1 - 2.2e-26 89.6 23.1 8.9e-05 22.1 0.0 9.0 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESA00744.1 - 1.8e-22 77.9 38.8 1.8e-07 30.4 0.1 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00744.1 - 5.5e-17 61.9 0.0 7.6e-05 23.2 0.0 5.0 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00744.1 - 8.2e-16 57.7 10.3 0.00048 20.0 0.1 5.3 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00744.1 - 1.4e-14 52.6 33.6 8.4e-06 25.2 0.4 8.8 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00744.1 - 1.3e-10 40.6 25.3 0.00012 21.9 0.1 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00744.1 - 1.1e-09 38.4 3.4 0.1 12.9 0.0 4.6 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESA00744.1 - 4.7e-08 32.7 0.0 8.4e-05 22.3 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00744.1 - 8.4e-08 32.2 0.0 8.4 7.3 0.0 6.4 2 2 5 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA00744.1 - 3e-07 29.7 12.0 0.81 9.6 0.0 7.3 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00744.1 - 3.7e-07 30.1 1.3 0.099 13.1 0.0 6.0 7 0 0 7 7 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA00744.1 - 0.00028 20.0 0.2 0.28 10.4 0.0 3.9 3 0 0 3 3 3 1 SHNi-TPR Fis1_TPR_C PF14853.1 ESA00744.1 - 0.0018 18.1 8.4 3.7 7.5 0.0 6.0 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat zf-C3HC4_3 PF13920.1 ESA00744.1 - 0.0097 15.5 2.4 0.019 14.6 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) APH PF01636.18 ESA00744.1 - 0.018 14.7 0.6 0.23 11.1 0.3 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family TPR_15 PF13429.1 ESA00744.1 - 0.035 13.1 0.0 0.31 10.0 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Kdo PF06293.9 ESA00744.1 - 0.056 12.5 0.4 0.14 11.2 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_5 PF14634.1 ESA00744.1 - 0.15 11.8 6.2 0.062 13.0 2.2 2.0 2 0 0 2 2 1 0 zinc-RING finger domain TPR_10 PF13374.1 ESA00744.1 - 0.53 10.2 1.7 37 4.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA00745.1 - 1.8e-45 152.3 24.1 1.1e-08 35.4 0.1 7.3 6 1 1 7 7 7 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00745.1 - 2e-28 99.1 0.4 3.1e-28 98.5 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00745.1 - 7.1e-25 87.6 4.0 7.1e-25 87.6 2.8 1.7 2 1 0 2 2 2 1 Protein kinase domain DUF605 PF04652.11 ESA00745.1 - 2.2 7.5 16.2 3.7 6.8 11.2 1.3 1 0 0 1 1 1 0 Vta1 like TPR_11 PF13414.1 ESA00746.1 - 4.9e-20 70.9 5.9 4.5e-10 39.0 0.3 2.5 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 ESA00746.1 - 1.8e-16 58.9 1.7 9.4e-07 28.1 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA00746.1 - 1.1e-14 53.0 0.2 7e-05 22.4 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00746.1 - 4.1e-10 38.7 4.0 2.1e-06 27.0 0.5 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA00746.1 - 4e-08 33.2 8.0 2.3e-05 24.4 0.7 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESA00746.1 - 4.4e-08 32.6 3.2 0.0049 16.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00746.1 - 0.00033 20.5 0.1 0.0077 16.1 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00746.1 - 0.0032 18.1 0.0 0.0066 17.0 0.0 1.5 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00746.1 - 0.0047 17.3 0.1 0.15 12.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA00746.1 - 0.0052 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00746.1 - 0.023 15.0 0.0 0.31 11.4 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA00746.1 - 0.051 13.4 0.8 1.3 8.9 0.0 3.2 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 ESA00746.1 - 0.11 12.3 0.1 2.3 8.2 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Dimer_Tnp_hAT PF05699.9 ESA00747.1 - 1.2e-05 24.8 0.1 3.2e-05 23.4 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA00747.1 - 0.022 14.7 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DBD_Tnp_Hermes PF10683.4 ESA00748.1 - 0.021 14.2 0.0 0.042 13.3 0.0 1.5 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain S-AdoMet_synt_M PF02772.11 ESA00748.1 - 0.044 13.7 0.2 0.23 11.3 0.0 2.0 1 1 0 2 2 2 0 S-adenosylmethionine synthetase, central domain bZIP_1 PF00170.16 ESA00749.1 - 0.00018 21.4 5.1 0.005 16.7 0.2 2.3 1 1 1 2 2 2 1 bZIP transcription factor Shugoshin_N PF07558.6 ESA00749.1 - 0.00048 19.7 1.9 0.48 10.1 0.0 2.6 2 1 1 3 3 3 2 Shugoshin N-terminal coiled-coil region GAS PF13851.1 ESA00749.1 - 0.00081 18.6 4.1 0.00087 18.5 2.8 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding bZIP_2 PF07716.10 ESA00749.1 - 0.0023 17.7 7.5 0.24 11.2 0.5 2.4 1 1 1 2 2 2 2 Basic region leucine zipper FlaC_arch PF05377.6 ESA00749.1 - 0.0052 16.6 3.1 1 9.3 0.1 2.3 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) DivIC PF04977.10 ESA00749.1 - 0.007 15.8 7.7 0.011 15.1 1.4 2.1 1 1 1 2 2 2 1 Septum formation initiator CENP-F_leu_zip PF10473.4 ESA00749.1 - 0.013 15.3 6.4 0.023 14.5 4.4 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tup_N PF08581.5 ESA00749.1 - 0.022 14.9 1.7 0.064 13.4 1.2 1.8 1 1 0 1 1 1 0 Tup N-terminal RBD-FIP PF09457.5 ESA00749.1 - 0.022 14.5 2.8 0.41 10.4 0.6 2.6 1 1 1 2 2 2 0 FIP domain TSC22 PF01166.13 ESA00749.1 - 0.025 14.5 5.1 0.13 12.2 0.5 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family TMF_DNA_bd PF12329.3 ESA00749.1 - 0.03 14.1 8.9 0.073 12.8 1.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Uso1_p115_C PF04871.8 ESA00749.1 - 0.035 14.0 3.8 0.048 13.6 2.6 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3818 PF12825.2 ESA00749.1 - 0.064 11.9 1.8 0.076 11.6 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) 120_Rick_ant PF12574.3 ESA00749.1 - 0.067 12.2 1.1 0.071 12.1 0.8 1.1 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen ADIP PF11559.3 ESA00749.1 - 0.069 13.0 3.8 0.085 12.7 2.6 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FemAB PF02388.11 ESA00749.1 - 0.07 11.8 3.4 0.077 11.6 2.3 1.0 1 0 0 1 1 1 0 FemAB family TMF_TATA_bd PF12325.3 ESA00749.1 - 0.077 12.7 5.7 0.087 12.5 3.9 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF972 PF06156.8 ESA00749.1 - 0.095 13.0 4.2 0.14 12.5 2.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Lge1 PF11488.3 ESA00749.1 - 0.12 12.5 2.5 0.85 9.8 1.7 2.0 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 Striatin PF08232.7 ESA00749.1 - 0.14 12.5 2.9 0.17 12.2 2.0 1.1 1 0 0 1 1 1 0 Striatin family BRE1 PF08647.6 ESA00749.1 - 0.14 12.1 4.3 0.18 11.8 3.0 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.2 ESA00749.1 - 0.14 11.9 6.8 0.22 11.3 2.9 1.8 1 1 0 1 1 1 0 Tropomyosin like DUF1875 PF08961.5 ESA00749.1 - 0.32 10.2 3.6 0.4 9.9 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) Atg14 PF10186.4 ESA00749.1 - 0.36 9.7 3.5 0.39 9.6 2.4 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4140 PF13600.1 ESA00749.1 - 0.58 10.6 7.4 3.6 8.0 0.5 2.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) IncA PF04156.9 ESA00749.1 - 0.61 9.6 4.6 0.71 9.4 3.2 1.2 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 ESA00749.1 - 0.69 8.8 4.6 0.84 8.6 3.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 NYD-SP28_assoc PF14775.1 ESA00749.1 - 1.6 8.5 6.3 3.3 7.4 0.6 2.6 2 1 1 3 3 3 0 Sperm tail C-terminal domain M PF02370.11 ESA00749.1 - 1.9 9.0 10.1 3.4 8.3 0.9 3.1 3 0 0 3 3 2 0 M protein repeat DUF4315 PF14193.1 ESA00749.1 - 7.5 6.5 11.1 4.9 7.1 3.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4315) Ras PF00071.17 ESA00750.1 - 6.4e-66 220.7 1.3 7.5e-66 220.4 0.9 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA00750.1 - 3.4e-20 72.7 0.0 5.3e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA00750.1 - 7.4e-18 64.3 0.2 9.3e-18 64.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA00750.1 - 1.1e-06 27.9 0.1 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA00750.1 - 1.6e-06 27.7 0.3 3.3e-06 26.6 0.2 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 ESA00750.1 - 2.3e-05 23.7 0.1 2.8e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESA00750.1 - 3.2e-05 23.8 0.1 6.9e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESA00750.1 - 0.0006 19.9 0.0 0.0017 18.4 0.0 1.7 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.13 ESA00750.1 - 0.0021 17.3 0.1 0.019 14.2 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.1 ESA00750.1 - 0.0028 17.6 0.1 0.052 13.5 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 ESA00750.1 - 0.0046 17.1 0.0 1.4 9.1 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA00750.1 - 0.0049 16.5 0.1 0.013 15.1 0.0 1.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.4 ESA00750.1 - 0.0059 16.0 0.1 0.11 12.0 0.0 2.3 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.11 ESA00750.1 - 0.014 14.6 0.2 0.059 12.5 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA00750.1 - 0.041 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 ESA00750.1 - 0.062 12.9 0.2 0.16 11.6 0.1 1.8 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 ESA00750.1 - 0.081 13.2 0.1 0.16 12.2 0.0 1.7 1 1 0 1 1 1 0 ABC transporter DUF1240 PF06836.7 ESA00751.1 - 6.2 7.1 16.0 2.3 8.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1240) WW PF00397.21 ESA00752.1 - 2.1e-08 33.8 1.8 3.7e-08 33.0 1.2 1.4 1 0 0 1 1 1 1 WW domain DinB_2 PF12867.2 ESA00753.1 - 5.1e-05 23.6 0.2 0.00038 20.8 0.1 2.0 1 1 0 1 1 1 1 DinB superfamily HTH_psq PF05225.11 ESA00753.1 - 0.028 13.9 0.1 0.58 9.7 0.0 2.7 3 0 0 3 3 3 0 helix-turn-helix, Psq domain Lipase_2 PF01674.13 ESA00754.1 - 0.0017 17.7 0.1 0.0044 16.3 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 2) S_layer_C PF05124.7 ESA00757.1 - 0.11 12.0 0.8 1 8.9 0.2 2.0 2 0 0 2 2 2 0 S-layer like family, C-terminal region Pkinase PF00069.20 ESA00758.1 - 7.1e-10 38.4 0.1 7.6e-10 38.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00758.1 - 0.00017 20.7 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA00758.1 - 0.056 13.1 0.0 0.07 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA00758.1 - 0.13 11.2 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA00759.1 - 2.9e-100 326.5 35.6 7.4e-08 32.7 0.0 12.0 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA00759.1 - 0.0035 17.6 23.8 2.6 8.6 0.1 10.2 12 0 0 12 12 12 1 Tetratricopeptide repeat CoA_binding PF02629.14 ESA00759.1 - 0.021 15.3 1.1 38 4.8 0.0 5.2 5 1 1 6 6 6 0 CoA binding domain NUMOD1 PF07453.8 ESA00759.1 - 1.7 8.6 18.3 17 5.4 0.1 6.6 7 0 0 7 7 7 0 NUMOD1 domain TPR_5 PF12688.2 ESA00759.1 - 4.9 7.2 11.8 1.2e+02 2.7 0.1 6.7 8 1 2 10 10 10 0 Tetratrico peptide repeat Sel1 PF08238.7 ESA00760.1 - 3e-80 262.8 25.3 1.4e-08 35.1 0.0 10.9 10 1 1 11 11 11 10 Sel1 repeat NUMOD1 PF07453.8 ESA00760.1 - 0.022 14.6 29.9 0.41 10.5 0.3 7.5 8 0 0 8 8 8 0 NUMOD1 domain Sel1 PF08238.7 ESA00761.1 - 4.5e-114 370.3 26.8 1.4e-08 35.0 0.1 15.0 16 0 0 16 16 16 14 Sel1 repeat TPR_6 PF13174.1 ESA00761.1 - 2.8e-13 49.3 20.9 3.8 8.1 0.0 12.2 13 0 0 13 13 13 4 Tetratricopeptide repeat BDM PF10684.4 ESA00761.1 - 5.8e-06 26.4 0.1 0.37 11.0 0.0 5.4 3 1 3 7 7 7 1 Putative biofilm-dependent modulation protein TRL PF13146.1 ESA00761.1 - 0.005 16.7 0.1 43 4.1 0.0 5.2 5 0 0 5 5 5 0 TRL-like protein family Chordopox_A13L PF05961.6 ESA00761.1 - 0.024 14.5 14.5 44 4.1 0.0 8.3 10 0 0 10 10 10 0 Chordopoxvirus A13L protein NUMOD1 PF07453.8 ESA00761.1 - 0.35 10.7 17.0 9.9 6.1 0.1 7.0 7 0 0 7 7 7 0 NUMOD1 domain DUF3225 PF11533.3 ESA00761.1 - 0.36 10.5 6.5 18 5.0 0.0 5.6 5 3 2 7 7 7 0 Protein of unknown function (DUF3225) Sel1 PF08238.7 ESA00762.1 - 1.5e-143 464.0 73.8 6.5e-13 48.8 0.6 13.1 13 0 0 13 13 13 13 Sel1 repeat MIT PF04212.13 ESA00762.1 - 4.8e-13 48.7 50.5 0.68 9.8 0.2 12.8 11 2 2 13 13 13 9 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA00762.1 - 1.2e-11 44.2 35.0 3.7 8.2 0.1 12.5 13 0 0 13 13 13 4 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA00762.1 - 6e-08 32.2 15.0 2.1 8.1 0.0 9.9 11 0 0 11 11 11 1 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA00762.1 - 0.00071 19.6 8.5 5.6 7.1 0.1 6.0 2 2 4 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00762.1 - 0.0027 17.7 53.0 5.6 7.4 0.2 13.1 13 1 1 14 14 14 3 Tetratricopeptide repeat ELYS PF13934.1 ESA00762.1 - 0.0051 16.5 0.2 6.5 6.4 0.0 4.4 1 1 4 5 5 5 1 Nuclear pore complex assembly TPR_12 PF13424.1 ESA00762.1 - 0.007 16.2 51.1 0.28 11.1 2.7 9.1 2 2 8 10 10 10 5 Tetratricopeptide repeat DUF2464 PF10240.4 ESA00762.1 - 0.085 12.1 0.6 4.6 6.5 0.0 3.4 4 1 1 5 5 5 0 Protein of unknown function (DUF2464) Leuk-A4-hydro_C PF09127.6 ESA00762.1 - 2.8 7.5 27.8 3.6 7.1 0.0 7.4 2 2 5 9 9 9 0 Leukotriene A4 hydrolase, C-terminal Acetyltransf_3 PF13302.1 ESA00762.1 - 4.9 7.3 9.7 16 5.6 0.2 4.2 1 1 0 3 3 3 0 Acetyltransferase (GNAT) domain Sel1 PF08238.7 ESA00763.1 - 1.5e-46 155.7 18.4 1.4e-12 47.8 0.1 5.5 6 0 0 6 6 6 4 Sel1 repeat MIT PF04212.13 ESA00763.1 - 4.9e-07 29.5 11.4 0.17 11.7 0.1 4.3 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA00763.1 - 3.7e-05 23.9 5.8 1 9.9 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00763.1 - 6.7e-05 22.7 14.6 2.5 8.5 0.0 6.3 4 1 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00763.1 - 8.3e-05 22.4 12.7 0.0034 17.2 1.6 4.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00763.1 - 0.00038 20.0 20.1 0.012 15.2 2.1 4.2 1 1 3 4 4 4 3 TPR repeat Surfac_D-trimer PF09006.6 ESA00763.1 - 0.003 17.2 3.0 18 5.1 0.0 4.0 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_2 PF07719.12 ESA00763.1 - 0.14 12.1 18.6 4.2 7.5 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA00763.1 - 0.29 11.1 6.0 3.3 7.7 0.0 4.6 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00763.1 - 2 8.3 10.8 2.9 7.9 0.4 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Sec62 PF03839.11 ESA00768.1 - 0.16 11.3 3.4 0.2 11.0 2.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Sel1 PF08238.7 ESA00769.1 - 1.4e-87 286.2 17.7 1.3e-11 44.7 0.1 10.1 10 0 0 10 10 10 9 Sel1 repeat TPR_6 PF13174.1 ESA00769.1 - 3.3e-06 27.1 12.1 1.7 9.2 0.1 7.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00769.1 - 0.00024 20.7 40.0 0.65 9.6 5.0 7.3 2 2 5 7 7 7 4 TPR repeat MIT PF04212.13 ESA00769.1 - 0.00088 19.1 21.8 3.1 7.7 2.1 7.4 5 2 2 7 7 7 3 MIT (microtubule interacting and transport) domain RNase_P_p30 PF01876.11 ESA00769.1 - 0.031 13.5 0.0 7.7 5.7 0.0 3.7 3 1 1 4 4 4 0 RNase P subunit p30 Acetyltransf_1 PF00583.19 ESA00769.1 - 0.053 13.5 4.8 26 4.9 0.0 5.3 5 2 1 6 6 6 0 Acetyltransferase (GNAT) family EF-hand_10 PF14788.1 ESA00769.1 - 0.12 12.0 8.9 12 5.6 0.0 6.2 6 1 1 7 7 7 0 EF hand DUF4495 PF14906.1 ESA00769.1 - 0.18 10.7 0.1 10 4.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4495) DUF4394 PF14339.1 ESA00769.1 - 0.18 11.0 3.4 9.4 5.4 0.1 3.4 2 2 2 4 4 4 0 Domain of unknown function (DUF4394) TPR_12 PF13424.1 ESA00769.1 - 0.33 10.9 29.1 4.4 7.3 1.6 7.5 2 2 7 9 9 9 0 Tetratricopeptide repeat NSF PF02071.15 ESA00769.1 - 0.51 11.1 15.3 3.9 8.4 0.1 7.5 8 0 0 8 8 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_7 PF13176.1 ESA00769.1 - 4.8 7.2 12.2 9.1 6.3 0.0 6.2 5 2 1 6 6 6 0 Tetratricopeptide repeat MerR_1 PF13411.1 ESA00770.1 - 0.12 12.1 0.2 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 MerR HTH family regulatory protein F-box-like PF12937.2 ESA00774.1 - 0.00072 19.2 1.6 0.0029 17.2 1.1 2.0 1 0 0 1 1 1 1 F-box-like VWA_3 PF13768.1 ESA00776.1 - 3.7e-30 104.6 0.0 6.5e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 ESA00776.1 - 1.3e-18 66.8 2.8 1.4e-18 66.7 1.0 1.8 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.23 ESA00776.1 - 3e-16 59.6 0.1 6e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA00776.1 - 8.4e-16 58.5 0.0 1.9e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESA00776.1 - 3.6e-05 23.1 0.0 6.6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain vWA-TerF-like PF10138.4 ESA00776.1 - 3.7e-05 23.6 0.0 6.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2828 PF11443.3 ESA00776.1 - 8.7e-05 20.9 0.1 0.00013 20.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DUF2201 PF09967.4 ESA00776.1 - 0.00079 19.4 0.0 0.0025 17.8 0.0 1.8 1 1 0 1 1 1 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.9 ESA00776.1 - 0.0084 15.2 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Hepatitis_core PF00906.15 ESA00776.1 - 0.031 13.9 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Hepatitis core antigen Luciferase_N PF05295.6 ESA00776.1 - 0.044 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain Ribosomal_S26e PF01283.14 ESA00777.1 - 0.0046 17.1 1.2 3.6 7.8 0.0 3.1 1 1 2 3 3 3 3 Ribosomal protein S26e VIT PF08487.5 ESA00778.1 - 2.9e-23 81.7 2.6 6.7e-23 80.6 0.6 2.0 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.1 ESA00778.1 - 1.8e-09 36.9 0.0 3.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Phage_tail PF04630.7 ESA00778.1 - 0.094 11.7 0.1 0.65 9.0 0.0 2.0 2 0 0 2 2 2 0 Phage major tail protein Pkinase PF00069.20 ESA00779.1 - 2.1e-12 46.7 0.0 2.3e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00779.1 - 3.4e-11 42.7 0.0 3.9e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase AHSP PF09236.5 ESA00781.1 - 0.02 15.0 0.2 0.021 15.0 0.1 1.1 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein FtsH_ext PF06480.10 ESA00782.1 - 0.0067 16.5 0.5 0.0085 16.2 0.4 1.2 1 0 0 1 1 1 1 FtsH Extracellular Myb_DNA-bind_4 PF13837.1 ESA00783.1 - 0.0036 17.3 1.1 0.0039 17.2 0.8 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain WD40 PF00400.27 ESA00786.1 - 2.3e-62 204.8 17.7 7.5e-10 38.3 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 ESA00786.1 - 1.7e-15 56.1 6.3 0.00092 17.4 0.0 6.0 1 1 5 6 6 6 6 Nucleoporin Nup120/160 F-box-like PF12937.2 ESA00786.1 - 1.2e-13 50.5 0.2 2.6e-13 49.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA00786.1 - 9.7e-10 37.8 0.3 2e-09 36.8 0.2 1.6 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.1 ESA00786.1 - 1.8e-06 27.5 0.1 0.0086 15.5 0.0 3.2 1 1 0 2 2 2 2 PQQ-like domain Nucleoporin_N PF08801.6 ESA00786.1 - 0.012 14.3 5.5 0.16 10.6 0.2 3.6 1 1 1 2 2 2 0 Nup133 N terminal like PQQ PF01011.16 ESA00786.1 - 0.14 11.7 0.0 36 4.1 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat CLASP_N PF12348.3 ESA00788.1 - 4.6e-09 35.9 5.5 3e-07 30.0 0.0 3.8 3 1 0 3 3 3 1 CLASP N terminal HEAT_2 PF13646.1 ESA00788.1 - 1.6e-07 31.4 2.0 0.011 15.9 0.0 4.2 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.17 ESA00788.1 - 2.7e-07 30.0 6.1 0.0085 16.0 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.2 ESA00788.1 - 1.3e-06 28.6 0.2 1.2 9.5 0.0 4.9 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region TIP120 PF08623.5 ESA00788.1 - 2.1e-05 24.1 2.2 0.00086 18.9 0.0 3.3 4 1 0 4 4 4 1 TATA-binding protein interacting (TIP20) Cnd1 PF12717.2 ESA00788.1 - 0.00061 19.6 0.7 0.71 9.6 0.0 4.2 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESA00788.1 - 0.01 16.2 4.1 0.65 10.5 0.0 4.3 5 0 0 5 5 5 0 HEAT-like repeat Alpha_kinase PF02816.13 ESA00790.1 - 2.9e-35 121.6 0.0 5.7e-35 120.6 0.0 1.5 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA00790.1 - 4.7e-08 33.3 0.0 7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA00790.1 - 0.0062 16.2 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Alpha_kinase PF02816.13 ESA00791.1 - 1.7e-38 132.1 0.0 2.9e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA00791.1 - 1.8e-07 31.4 0.0 2.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA00791.1 - 0.00048 19.9 0.0 0.00089 19.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Bromodomain PF00439.20 ESA00793.1 - 1e-18 67.0 0.1 1.2e-18 66.8 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Mga PF05043.8 ESA00793.1 - 0.094 13.0 0.1 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 Mga helix-turn-helix domain Methyltransf_11 PF08241.7 ESA00795.1 - 5.4e-09 36.4 0.0 1.1e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA00795.1 - 1.9e-07 30.8 0.0 8.5e-07 28.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA00795.1 - 2.8e-06 27.5 0.0 6.3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA00795.1 - 5.1e-06 27.0 0.0 4.7e-05 23.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA00795.1 - 1.2e-05 25.0 0.0 3.9e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA00795.1 - 0.00026 20.2 0.0 0.00051 19.2 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA00795.1 - 0.00031 19.8 0.0 0.0022 17.0 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA00795.1 - 0.0023 17.9 0.0 0.0057 16.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA00795.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L36 PF00444.13 ESA00796.1 - 3.9e-20 71.5 10.8 4.8e-20 71.2 7.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.12 ESA00796.1 - 0.026 13.8 0.7 0.033 13.4 0.5 1.2 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Peptidase_C9 PF01707.11 ESA00797.1 - 0.11 12.0 1.7 2.3 7.7 1.2 2.1 1 1 0 1 1 1 0 Peptidase family C9 HMG_box PF00505.14 ESA00799.1 - 1.4e-05 25.3 0.7 2.9e-05 24.2 0.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA00799.1 - 0.0026 18.0 0.9 0.0053 17.1 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain DUF1477 PF07346.6 ESA00800.1 - 0.013 15.5 0.3 0.11 12.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1477) PRD_Mga PF08270.6 ESA00800.1 - 0.21 10.8 2.9 0.97 8.6 0.1 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) PRD domain Sel1 PF08238.7 ESA00801.1 - 4e-236 758.3 141.2 3.2e-11 43.5 0.2 25.3 25 0 0 25 25 25 25 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00801.1 - 7.7e-44 149.6 0.0 1.1e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00801.1 - 1.6e-42 145.4 0.3 2.6e-42 144.7 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Aurora-A_bind PF09041.5 ESA00801.1 - 7.9e-07 28.7 7.5 6.1 6.6 0.0 8.3 9 1 2 11 11 11 2 Aurora-A binding RIO1 PF01163.17 ESA00801.1 - 0.00069 19.0 0.2 0.0016 17.7 0.1 1.7 1 0 0 1 1 1 1 RIO1 family NTPase_I-T PF01931.13 ESA00801.1 - 0.026 14.2 2.2 24 4.6 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function DUF84 Kinase-like PF14531.1 ESA00801.1 - 0.035 13.0 0.0 0.06 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA00801.1 - 0.048 13.3 0.3 0.087 12.5 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_6 PF13174.1 ESA00801.1 - 0.11 13.0 48.6 23 5.7 0.0 13.6 14 0 0 14 14 14 0 Tetratricopeptide repeat W2 PF02020.13 ESA00801.1 - 0.78 9.7 33.5 1.4 8.9 0.6 6.7 7 1 0 7 7 7 0 eIF4-gamma/eIF5/eIF2-epsilon p450 PF00067.17 ESA00802.1 - 6.7e-92 308.4 0.0 8.4e-92 308.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA00803.1 - 8.5e-59 199.2 0.0 1.1e-58 198.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NuA4 PF09340.5 ESA00806.1 - 6.6e-25 86.5 0.6 6.6e-25 86.5 0.4 2.1 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Mitochondr_Som1 PF11093.3 ESA00806.1 - 0.055 13.2 0.2 4.1 7.2 0.0 2.5 1 1 2 3 3 3 0 Mitochondrial export protein Som1 GCN5L1 PF06320.8 ESA00806.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.0 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) YABBY PF04690.8 ESA00806.1 - 0.22 11.7 1.8 0.35 11.0 1.2 1.3 1 0 0 1 1 1 0 YABBY protein Enkurin PF13864.1 ESA00806.1 - 4.2 7.6 7.3 2 8.6 0.3 3.0 2 2 0 2 2 2 0 Calmodulin-binding Arrestin_N PF00339.24 ESA00807.1 - 6.2e-15 55.3 0.1 5.7e-10 39.2 0.0 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA00807.1 - 3.1e-10 40.2 0.0 8.5e-10 38.8 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.5 ESA00807.1 - 0.0035 16.4 5.3 0.0097 15.0 0.5 2.6 3 1 0 3 3 3 2 Rgp1 Oest_recep PF02159.10 ESA00807.1 - 0.1 12.7 1.8 0.21 11.7 1.3 1.4 1 0 0 1 1 1 0 Oestrogen receptor Exo_endo_phos PF03372.18 ESA00808.1 - 6e-21 75.5 0.2 7.9e-21 75.1 0.2 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA00808.1 - 0.0068 16.0 0.1 0.021 14.4 0.1 1.8 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase WD40 PF00400.27 ESA00809.1 - 4.7e-20 70.6 0.9 0.012 15.4 0.0 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat Asparaginase PF00710.15 ESA00810.1 - 6.5e-36 123.7 0.0 7.6e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Asparaginase Sel1 PF08238.7 ESA00811.1 - 3.1e-81 266.0 31.0 1.4e-11 44.5 0.1 10.7 11 0 0 11 11 11 10 Sel1 repeat TPR_6 PF13174.1 ESA00811.1 - 7.4e-06 26.0 11.9 0.75 10.3 0.0 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA00811.1 - 0.0055 16.4 0.9 3.3 7.5 0.0 3.5 3 1 1 4 4 4 2 Aurora-A binding DUF3791 PF12668.2 ESA00811.1 - 10 5.8 8.8 1.1 8.9 0.8 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3791) Trypsin_2 PF13365.1 ESA00813.1 - 0.00031 20.6 0.0 0.00074 19.4 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 ESA00813.1 - 0.0021 17.6 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.8 ESA00813.1 - 0.13 11.2 0.1 0.81 8.6 0.0 1.9 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Sel1 PF08238.7 ESA00814.1 - 3.7e-243 780.7 135.5 7.5e-11 42.2 0.5 31.0 31 0 0 31 31 31 30 Sel1 repeat Pkinase_Tyr PF07714.12 ESA00814.1 - 2.4e-44 151.3 0.0 3.6e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00814.1 - 1.5e-43 148.8 0.6 2.6e-43 148.0 0.4 1.4 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA00814.1 - 0.046 12.6 0.0 0.083 11.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA00814.1 - 0.61 9.7 0.1 1.1 8.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Arch_ATPase PF01637.13 ESA00816.1 - 1.4e-08 34.7 0.0 1.9e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA00816.1 - 2.4e-06 27.6 0.0 2.9e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 ESA00816.1 - 0.0022 17.9 0.1 0.0073 16.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.10 ESA00816.1 - 0.018 13.7 0.0 0.02 13.5 0.0 1.0 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_33 PF13671.1 ESA00816.1 - 0.02 14.7 0.1 0.051 13.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 ESA00816.1 - 0.058 13.1 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESA00816.1 - 0.079 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ESA00816.1 - 0.081 12.4 0.0 0.19 11.3 0.0 1.6 1 1 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 ESA00816.1 - 0.083 13.3 0.0 0.2 12.1 0.0 1.6 2 0 0 2 2 2 0 Miro-like protein cobW PF02492.14 ESA00816.1 - 0.089 12.2 0.1 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 ESA00816.1 - 0.11 12.4 0.1 0.22 11.4 0.0 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRPRB PF09439.5 ESA00816.1 - 0.11 11.7 0.1 0.27 10.4 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 ESA00816.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESA00816.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.1 ESA00816.1 - 0.13 11.8 0.1 0.16 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESA00816.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 NTPase DUF3579 PF12112.3 ESA00817.1 - 0.089 12.7 0.1 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3579) HLH PF00010.21 ESA00819.1 - 1.4e-19 69.5 0.4 3.1e-19 68.4 0.0 1.8 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain CBM_2 PF00553.14 ESA00819.1 - 0.02 14.8 0.1 0.038 14.0 0.1 1.4 1 0 0 1 1 1 0 Cellulose binding domain Apc9 PF12856.2 ESA00820.1 - 0.14 12.2 0.5 0.39 10.8 0.0 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 9 DUF651 PF04895.7 ESA00822.1 - 0.013 15.1 0.3 0.016 14.8 0.2 1.2 1 0 0 1 1 1 0 Archaeal protein of unknown function (DUF651) NPR2 PF06218.6 ESA00823.1 - 0.036 12.7 2.6 0.045 12.4 1.8 1.1 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Peptidase_A2B PF12384.3 ESA00823.1 - 0.069 12.4 0.1 0.091 12.0 0.1 1.1 1 0 0 1 1 1 0 Ty3 transposon peptidase SAM_1 PF00536.25 ESA00825.1 - 0.08 13.1 0.0 0.36 11.0 0.0 2.1 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) TSC22 PF01166.13 ESA00826.1 - 0.00032 20.5 4.3 0.00032 20.5 3.0 3.4 1 1 1 3 3 3 1 TSC-22/dip/bun family Shugoshin_N PF07558.6 ESA00826.1 - 0.00068 19.2 13.6 0.0025 17.4 1.9 4.0 3 1 0 3 3 3 1 Shugoshin N-terminal coiled-coil region bZIP_1 PF00170.16 ESA00826.1 - 0.012 15.4 2.6 0.012 15.4 1.8 3.3 2 1 2 4 4 4 0 bZIP transcription factor DivIC PF04977.10 ESA00826.1 - 0.018 14.4 5.6 0.018 14.4 3.9 2.9 2 1 1 3 3 3 0 Septum formation initiator HALZ PF02183.13 ESA00826.1 - 0.034 13.8 4.3 0.62 9.8 0.7 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 ESA00826.1 - 0.082 13.2 17.7 0.2 12.0 2.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF972) NYD-SP28_assoc PF14775.1 ESA00826.1 - 0.1 12.3 14.7 0.31 10.7 1.8 3.5 2 1 2 4 4 4 0 Sperm tail C-terminal domain DUF904 PF06005.7 ESA00826.1 - 0.15 12.3 20.1 0.24 11.7 2.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF904) DUF465 PF04325.8 ESA00826.1 - 0.17 11.6 5.7 3.8 7.3 0.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF465) Fez1 PF06818.10 ESA00826.1 - 1.1 9.2 13.0 0.15 12.0 6.2 1.6 2 0 0 2 2 2 0 Fez1 DUF1635 PF07795.6 ESA00826.1 - 2 7.7 11.7 0.25 10.6 4.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) IFP_35_N PF07334.8 ESA00826.1 - 3.4 7.6 8.0 0.98 9.4 1.1 2.9 2 1 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus GAGA_bind PF06217.7 ESA00826.1 - 4.4 7.1 8.0 5.4 6.9 5.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2216 PF10226.4 ESA00826.1 - 7 6.0 12.9 0.27 10.7 1.2 3.0 2 1 1 3 3 3 0 Uncharacterized conserved proteins (DUF2216) DUF2358 PF10184.4 ESA00827.1 - 0.29 11.0 4.8 0.3 11.0 0.6 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2358) Stap_Strp_toxin PF01123.15 ESA00828.1 - 0.13 12.7 6.6 2.6 8.5 0.7 2.4 1 1 1 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain rve_3 PF13683.1 ESA00829.1 - 0.097 12.2 0.1 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain HSDR_N PF04313.9 ESA00830.1 - 0.00013 21.8 1.2 0.00031 20.5 0.8 1.8 1 1 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) RPAP1_C PF08620.5 ESA00831.1 - 1.4e-24 85.6 0.0 3.5e-24 84.4 0.0 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 ESA00831.1 - 7e-09 35.1 1.6 7e-09 35.1 1.1 2.2 2 0 0 2 2 2 1 RPAP1-like, N-terminal RQC PF09382.5 ESA00832.1 - 0.067 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 RQC domain TPR_11 PF13414.1 ESA00833.1 - 1.6e-18 66.1 30.9 1.2e-06 28.0 0.7 5.8 3 2 1 5 5 5 5 TPR repeat TPR_2 PF07719.12 ESA00833.1 - 1e-11 43.8 25.0 0.09 12.7 0.1 7.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA00833.1 - 3.9e-09 36.9 0.0 0.016 15.8 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA00833.1 - 5.7e-08 32.7 32.7 0.0075 16.3 0.5 5.0 3 2 0 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESA00833.1 - 6.1e-08 31.9 38.0 0.081 12.5 0.3 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA00833.1 - 1.1e-07 31.0 33.8 0.0023 17.5 1.0 7.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00833.1 - 1.7e-07 31.0 18.5 0.004 17.0 0.1 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA00833.1 - 9.6e-07 28.5 26.8 0.0089 16.1 0.1 8.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA00833.1 - 6.4e-05 23.2 10.4 1.4 9.2 0.1 4.7 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESA00833.1 - 0.0033 17.2 0.0 0.16 11.8 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA00833.1 - 0.029 14.9 0.0 21 6.0 0.0 4.3 4 1 2 6 6 5 0 Tetratricopeptide repeat Hint PF01079.15 ESA00836.1 - 6.9e-31 107.1 0.0 1.5e-30 106.0 0.0 1.5 2 0 0 2 2 1 1 Hint module AIG1 PF04548.11 ESA00836.1 - 1.3e-20 73.3 0.1 2e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA00836.1 - 6.9e-10 38.8 0.0 1.8e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESA00836.1 - 1.6e-05 24.2 2.2 8.5e-05 21.8 0.0 2.6 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit AAA_18 PF13238.1 ESA00836.1 - 3.3e-05 24.1 0.1 0.00012 22.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain Dynamin_N PF00350.18 ESA00836.1 - 4.4e-05 23.3 2.2 0.25 11.1 0.0 3.1 2 1 1 3 3 3 2 Dynamin family AAA_22 PF13401.1 ESA00836.1 - 5.8e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Septin PF00735.13 ESA00836.1 - 9.2e-05 21.5 0.0 0.00021 20.3 0.0 1.5 1 0 0 1 1 1 1 Septin AAA_16 PF13191.1 ESA00836.1 - 9.3e-05 22.4 0.0 0.00023 21.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESA00836.1 - 0.00029 21.6 0.1 0.0013 19.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain Vint PF14623.1 ESA00836.1 - 0.00038 19.9 0.0 0.00071 19.1 0.0 1.5 1 0 0 1 1 1 1 Hint-domain DUF258 PF03193.11 ESA00836.1 - 0.00059 19.0 0.0 0.0015 17.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA00836.1 - 0.00072 19.0 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain T2SE PF00437.15 ESA00836.1 - 0.00076 18.4 0.0 0.002 17.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 ESA00836.1 - 0.0036 16.8 0.1 0.0076 15.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 ESA00836.1 - 0.005 17.3 0.1 0.016 15.7 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 ESA00836.1 - 0.0052 17.0 0.0 0.04 14.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter MobB PF03205.9 ESA00836.1 - 0.0058 16.3 0.1 0.041 13.5 0.0 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activ_2 PF14532.1 ESA00836.1 - 0.006 16.6 0.0 0.51 10.3 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain DUF87 PF01935.12 ESA00836.1 - 0.0083 15.9 0.2 0.033 14.0 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 ESA00836.1 - 0.0084 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_33 PF13671.1 ESA00836.1 - 0.0084 15.9 0.0 0.019 14.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain Ras PF00071.17 ESA00836.1 - 0.01 15.2 0.4 0.017 14.4 0.3 1.3 1 0 0 1 1 1 0 Ras family NB-ARC PF00931.17 ESA00836.1 - 0.011 14.5 0.5 0.08 11.7 0.0 2.3 2 1 1 3 3 3 0 NB-ARC domain Sigma54_activat PF00158.21 ESA00836.1 - 0.015 14.7 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain GTP_EFTU PF00009.22 ESA00836.1 - 0.021 14.2 0.7 0.13 11.6 0.1 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain NACHT PF05729.7 ESA00836.1 - 0.024 14.2 0.0 0.073 12.7 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.1 ESA00836.1 - 0.027 14.3 0.1 0.069 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA00836.1 - 0.032 14.3 0.0 0.19 11.9 0.0 2.2 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.9 ESA00836.1 - 0.033 13.1 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain PduV-EutP PF10662.4 ESA00836.1 - 0.037 13.5 0.3 0.19 11.2 0.0 2.4 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 ESA00836.1 - 0.039 13.8 0.0 0.1 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF587 PF04532.7 ESA00836.1 - 0.043 12.7 0.1 0.12 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF587) DUF334 PF03904.8 ESA00836.1 - 0.074 12.3 0.8 1.8 7.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF334) FeoB_N PF02421.13 ESA00836.1 - 0.085 12.1 0.0 0.34 10.1 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_23 PF13476.1 ESA00836.1 - 0.39 11.0 10.4 8.7 6.6 7.2 2.4 1 1 0 1 1 1 0 AAA domain SAM_2 PF07647.12 ESA00837.1 - 2.3e-11 43.3 0.0 4.3e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA00837.1 - 8.5e-09 35.4 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PP1c_bdg PF10488.4 ESA00838.1 - 2.1 7.4 9.0 2.2 7.4 6.3 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region DUF2226 PF09987.4 ESA00839.1 - 0.023 13.8 0.6 0.29 10.2 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) HCBP_related PF06594.6 ESA00839.1 - 1.5 8.4 4.7 1 9.0 0.3 2.5 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain BAR PF03114.13 ESA00840.1 - 8.1e-42 143.2 10.4 8.9e-42 143.1 7.2 1.0 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.4 ESA00840.1 - 3.5e-08 32.7 12.9 1.7e-07 30.4 8.9 1.8 1 1 1 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF1501 PF07394.7 ESA00840.1 - 0.009 14.8 0.3 0.013 14.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) TMF_TATA_bd PF12325.3 ESA00840.1 - 0.045 13.4 10.6 0.23 11.2 4.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.17 ESA00840.1 - 0.23 11.5 6.6 0.42 10.6 1.7 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AHH PF14412.1 ESA00840.1 - 0.43 10.5 3.1 4.7 7.2 0.3 2.9 2 1 1 3 3 3 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF342 PF03961.8 ESA00840.1 - 1.1 7.5 11.0 0.36 9.2 5.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Laminin_I PF06008.9 ESA00840.1 - 1.6 7.9 12.2 0.56 9.4 5.2 2.3 2 1 0 2 2 2 0 Laminin Domain I FliJ PF02050.11 ESA00840.1 - 4.8 7.2 14.6 0.47 10.5 6.5 2.0 2 1 0 2 2 2 0 Flagellar FliJ protein Atg14 PF10186.4 ESA00840.1 - 4.8 6.0 7.1 0.64 8.9 1.6 1.8 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 PRKCSH-like PF12999.2 ESA00841.1 - 1.4e-47 161.5 4.2 1.4e-47 161.5 2.9 2.8 3 1 1 4 4 4 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 ESA00841.1 - 1.6e-30 105.6 3.0 1.6e-30 105.6 2.1 2.5 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 ESA00841.1 - 8.7e-07 29.6 2.8 8.7e-07 29.6 1.9 2.4 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein HalX PF08663.5 ESA00841.1 - 0.073 13.0 0.3 0.073 13.0 0.2 3.3 4 0 0 4 4 4 0 HalX domain Ldl_recept_a PF00057.13 ESA00841.1 - 6.2 6.8 19.3 2.4 8.1 3.7 2.8 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A Sybindin PF04099.7 ESA00842.1 - 1e-54 184.1 0.2 1.1e-54 183.9 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 ESA00842.1 - 2.6e-10 40.2 0.0 3.3e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF1674 PF07896.7 ESA00843.1 - 0.00061 19.9 5.7 0.00092 19.3 3.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) p450 PF00067.17 ESA00846.1 - 2.8e-39 134.9 0.0 3.2e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA00846.1 - 0.059 13.3 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) SET PF00856.23 ESA00847.1 - 3.9e-05 24.0 0.6 0.00046 20.5 0.0 3.1 3 0 0 3 3 3 1 SET domain DNA_mis_repair PF01119.14 ESA00848.1 - 8.3e-34 115.5 0.2 1.6e-33 114.7 0.2 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESA00848.1 - 4.6e-15 55.4 0.1 4.6e-15 55.4 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA00848.1 - 4.1e-10 39.3 0.0 1.1e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sedlin_N PF04628.8 ESA00848.1 - 0.033 14.0 0.5 0.083 12.7 0.4 1.7 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Adaptin_N PF01602.15 ESA00849.1 - 2.6e-58 197.6 0.3 2.9e-58 197.4 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESA00849.1 - 1e-10 41.7 0.0 2.8e-06 27.5 0.0 2.9 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.17 ESA00849.1 - 9.9e-07 28.3 0.1 0.0011 18.8 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.2 ESA00849.1 - 0.0004 20.2 0.6 0.0097 15.7 0.0 3.0 1 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESA00849.1 - 0.026 15.0 0.1 0.21 12.1 0.0 2.7 2 1 0 2 2 2 0 HEAT-like repeat HEAT_PBS PF03130.11 ESA00849.1 - 0.075 13.5 0.2 1.3e+02 3.4 0.0 4.1 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Metallophos PF00149.23 ESA00850.1 - 2.8e-44 150.9 0.1 3.4e-44 150.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF952 PF06108.7 ESA00852.1 - 2.7e-21 75.2 0.0 2.9e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Ion_trans PF00520.26 ESA00854.1 - 0.0002 20.6 14.5 0.00027 20.2 10.1 1.2 1 0 0 1 1 1 1 Ion transport protein zf-DHHC PF01529.15 ESA00854.1 - 0.37 10.1 11.2 2.6 7.4 5.1 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase HMG_box PF00505.14 ESA00859.1 - 0.0018 18.4 0.9 0.0035 17.5 0.6 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA00859.1 - 0.03 14.6 0.8 0.056 13.8 0.5 1.4 1 0 0 1 1 1 0 HMG-box domain DUF943 PF06092.7 ESA00859.1 - 0.048 12.9 0.1 0.055 12.7 0.1 1.3 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) DUF845 PF05820.6 ESA00859.1 - 0.056 13.1 0.6 0.15 11.8 0.1 1.8 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF845) Rotamase_2 PF13145.1 ESA00859.1 - 0.19 12.3 1.2 0.26 11.9 0.3 1.6 2 0 0 2 2 2 0 PPIC-type PPIASE domain DUF1411 PF07199.6 ESA00861.1 - 0.0051 16.2 0.7 0.0059 16.0 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) Lge1 PF11488.3 ESA00861.1 - 0.22 11.7 1.2 0.34 11.1 0.3 1.6 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 CDC45 PF02724.9 ESA00865.1 - 8.6 4.2 9.3 9.6 4.1 6.5 1.0 1 0 0 1 1 1 0 CDC45-like protein AAA_13 PF13166.1 ESA00866.1 - 0.00086 17.9 10.0 0.001 17.6 7.0 1.0 1 0 0 1 1 1 1 AAA domain Laminin_II PF06009.7 ESA00866.1 - 0.0066 16.2 8.0 0.16 11.7 0.1 2.7 1 1 1 2 2 2 1 Laminin Domain II Dor1 PF04124.7 ESA00866.1 - 0.016 13.6 0.8 0.016 13.6 0.6 2.1 1 1 1 2 2 2 0 Dor1-like family Bunya_G1 PF03557.10 ESA00866.1 - 0.03 12.1 1.4 0.032 12.0 1.0 1.0 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 Fib_alpha PF08702.5 ESA00866.1 - 0.034 14.2 11.4 0.47 10.5 2.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF948 PF06103.6 ESA00866.1 - 0.035 13.9 4.9 1.2 9.0 0.7 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Nup54 PF13874.1 ESA00866.1 - 0.041 13.5 7.1 0.039 13.6 2.2 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 YvbH_ext PF11724.3 ESA00866.1 - 0.042 13.5 2.1 5 6.8 0.2 2.4 2 0 0 2 2 2 0 YvbH-like oligomerisation region UPF0227 PF05728.7 ESA00866.1 - 0.079 12.6 2.8 0.061 13.0 0.9 1.5 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0227) TBPIP PF07106.8 ESA00866.1 - 0.083 12.4 15.8 0.37 10.3 6.6 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MCPsignal PF00015.16 ESA00866.1 - 0.091 12.2 3.6 1.5 8.3 0.4 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Mnd1 PF03962.10 ESA00866.1 - 0.16 11.6 10.0 0.27 10.8 6.9 1.4 1 0 0 1 1 1 0 Mnd1 family WXG100 PF06013.7 ESA00866.1 - 0.17 11.8 6.9 0.18 11.8 0.2 3.2 1 1 2 3 3 3 0 Proteins of 100 residues with WXG DUF1664 PF07889.7 ESA00866.1 - 0.18 11.5 10.0 0.26 11.0 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) COG5 PF10392.4 ESA00866.1 - 0.22 11.5 9.9 2.4 8.1 5.2 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 HN PF00423.14 ESA00866.1 - 0.22 9.7 1.1 0.28 9.4 0.7 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase Ku_C PF03730.9 ESA00866.1 - 0.24 11.9 4.6 0.47 11.0 3.2 1.6 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm Cauli_AT PF03233.8 ESA00866.1 - 0.34 10.6 7.9 0.3 10.7 4.5 1.6 1 1 1 2 2 2 0 Aphid transmission protein Spc7 PF08317.6 ESA00866.1 - 0.36 9.4 14.4 0.64 8.6 9.9 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein PEP-utilisers_N PF05524.8 ESA00866.1 - 0.44 10.3 3.2 0.89 9.3 1.5 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal LytTR PF04397.10 ESA00866.1 - 0.44 10.6 4.5 1.9 8.5 0.5 2.3 1 1 1 2 2 2 0 LytTr DNA-binding domain Cob_adeno_trans PF01923.13 ESA00866.1 - 0.51 10.1 5.4 0.21 11.3 0.8 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Baculo_PEP_C PF04513.7 ESA00866.1 - 0.54 10.0 6.7 1.4 8.7 2.9 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PilJ PF13675.1 ESA00866.1 - 0.68 10.2 4.2 1.7 9.0 0.4 2.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Seryl_tRNA_N PF02403.17 ESA00866.1 - 0.7 9.9 16.1 2.2 8.3 7.6 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RP-C_C PF11800.3 ESA00866.1 - 0.74 9.4 4.5 1 8.9 3.1 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region CENP-K PF11802.3 ESA00866.1 - 0.75 8.9 12.4 1 8.5 8.6 1.1 1 0 0 1 1 1 0 Centromere-associated protein K DUF2968 PF11180.3 ESA00866.1 - 0.81 9.0 7.7 0.51 9.7 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Syntaxin-6_N PF09177.6 ESA00866.1 - 0.98 9.8 11.1 12 6.3 6.6 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Dna2 PF08696.6 ESA00866.1 - 0.99 8.6 7.4 6.7 5.9 3.1 2.1 1 1 1 2 2 2 0 DNA replication factor Dna2 Prominin PF05478.6 ESA00866.1 - 1.1 6.7 7.4 1.5 6.2 5.2 1.2 1 0 0 1 1 1 0 Prominin GLE1 PF07817.8 ESA00866.1 - 1.4 7.7 6.6 1.5 7.6 0.1 2.1 1 1 1 2 2 2 0 GLE1-like protein Exonuc_VII_L PF02601.10 ESA00866.1 - 1.6 7.8 11.7 0.54 9.3 5.0 1.9 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF2400 PF09674.5 ESA00866.1 - 1.7 8.2 6.2 8.4 6.0 3.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) Prefoldin PF02996.12 ESA00866.1 - 1.8 8.2 11.4 5 6.7 3.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit TMPIT PF07851.8 ESA00866.1 - 2.8 6.9 12.2 1.2 8.1 4.8 1.9 1 1 1 2 2 2 0 TMPIT-like protein ACCA PF03255.9 ESA00866.1 - 3 7.3 6.3 0.47 9.9 1.6 1.7 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Synaptonemal_3 PF15191.1 ESA00866.1 - 3.2 7.5 6.2 27 4.6 1.3 2.7 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 APG6 PF04111.7 ESA00866.1 - 3.5 6.5 16.6 5.7 5.8 11.4 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Tweety PF04906.8 ESA00866.1 - 3.5 5.9 5.3 16 3.7 0.0 2.0 1 1 1 2 2 2 0 Tweety Synaptobrevin PF00957.16 ESA00866.1 - 4 7.0 9.1 14 5.3 3.7 2.8 2 1 1 3 3 3 0 Synaptobrevin DUF4164 PF13747.1 ESA00866.1 - 4.2 7.5 10.1 1.7 8.8 3.7 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) DUF342 PF03961.8 ESA00866.1 - 7.4 4.8 12.7 23 3.2 8.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Syntaxin PF00804.20 ESA00866.1 - 7.6 6.7 17.4 29 4.8 11.3 2.3 1 1 0 1 1 1 0 Syntaxin Cauli_DNA-bind PF03310.8 ESA00866.1 - 8.3 6.2 8.4 0.96 9.3 0.4 2.1 2 1 1 3 3 2 0 Caulimovirus DNA-binding protein HECT PF00632.20 ESA00867.1 - 2.2e-83 280.0 0.6 4.6e-83 278.9 0.1 1.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF772 PF05598.6 ESA00867.1 - 0.047 13.5 1.8 0.98 9.3 0.1 3.5 2 1 1 3 3 3 0 Transposase domain (DUF772) Seadorna_VP7 PF07387.6 ESA00868.1 - 0.058 12.2 0.2 0.084 11.6 0.2 1.3 1 1 0 1 1 1 0 Seadornavirus VP7 Lenti_VIF_2 PF07401.7 ESA00868.1 - 0.32 10.0 2.5 0.43 9.6 0.4 1.9 1 1 1 2 2 2 0 Bovine Lentivirus VIF protein RVT_1 PF00078.22 ESA00869.1 - 0.00016 21.0 0.0 0.0002 20.7 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SieB PF14163.1 ESA00872.1 - 0.00065 19.2 0.9 0.00065 19.2 0.6 2.3 2 0 0 2 2 2 1 Superinfection exclusion protein B Dimer_Tnp_hAT PF05699.9 ESA00873.1 - 3.2e-06 26.6 0.0 6.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DNA_pol_E_B PF04042.11 ESA00873.1 - 0.066 12.4 0.1 0.085 12.0 0.1 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B DDE_1 PF03184.14 ESA00874.1 - 6.1e-10 38.6 0.2 6.6e-10 38.4 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Anophelin PF10731.4 ESA00875.1 - 0.098 12.7 1.2 0.13 12.3 0.8 1.3 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Acyl-CoA_dh_M PF02770.14 ESA00876.1 - 3.7e-10 39.1 0.1 1.3e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.14 ESA00876.1 - 6.2e-08 32.2 0.1 9.1e-08 31.6 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.19 ESA00876.1 - 2.7e-07 30.8 0.0 6.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Methyltransf_14 PF08484.6 ESA00878.1 - 0.056 12.9 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain 2OG-Fe_Oxy_2 PF10014.4 ESA00879.1 - 0.089 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 2OG-Fe dioxygenase Pkinase_Tyr PF07714.12 ESA00881.1 - 1.8e-36 125.5 0.0 3.7e-36 124.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00881.1 - 4.4e-32 111.2 0.0 6.1e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA00881.1 - 0.0007 18.7 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA00881.1 - 0.0014 18.3 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA00881.1 - 0.0032 16.4 0.0 0.0043 16.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like PsbU PF06514.6 ESA00881.1 - 0.042 13.6 0.0 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) RIO1 PF01163.17 ESA00881.1 - 0.085 12.1 0.1 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESA00881.1 - 0.15 11.6 0.8 0.43 10.1 0.3 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 ESA00882.1 - 9.5e-41 139.5 0.0 1.1e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00882.1 - 7.3e-39 133.4 0.0 9.3e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA00882.1 - 0.0022 17.7 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA00882.1 - 0.0056 15.7 0.3 0.0082 15.2 0.2 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA00882.1 - 0.028 13.3 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ESA00882.1 - 0.06 12.6 0.1 0.096 12.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESA00882.1 - 0.075 12.6 0.2 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase WaaY PF06176.6 ESA00882.1 - 0.081 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) PsbU PF06514.6 ESA00882.1 - 0.091 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Sel1 PF08238.7 ESA00883.1 - 4e-75 246.6 47.5 3.5e-10 40.1 0.3 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA00883.1 - 3.4e-06 27.1 20.5 1.1 9.8 0.0 7.7 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA00883.1 - 0.0022 17.6 15.4 2.6 8.0 0.1 5.9 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00883.1 - 0.23 11.1 34.9 4.4 7.0 0.3 6.3 3 1 2 5 5 5 0 TPR repeat TPR_12 PF13424.1 ESA00883.1 - 1.6 8.7 17.1 2.1 8.3 0.9 5.8 4 2 1 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA00884.1 - 1.2e-06 28.9 0.0 1.6e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Sel1 repeat AIG1 PF04548.11 ESA00885.1 - 1.5e-19 69.9 1.4 4.4e-19 68.4 1.0 1.8 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA00885.1 - 6.2e-10 39.0 0.1 2.8e-09 36.9 0.1 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA00885.1 - 2.9e-06 27.6 0.0 2.9e-06 27.6 0.0 3.8 1 1 1 3 3 3 1 ABC transporter DUF258 PF03193.11 ESA00885.1 - 3.9e-06 26.1 0.0 1e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA00885.1 - 0.00077 18.9 2.3 0.17 11.2 0.0 2.6 3 0 0 3 3 3 2 AAA-like domain FeoB_N PF02421.13 ESA00885.1 - 0.00088 18.5 0.1 0.0027 16.9 0.0 1.9 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_17 PF13207.1 ESA00885.1 - 0.0012 19.6 0.1 0.0012 19.6 0.1 4.0 3 1 0 3 3 3 1 AAA domain Ras PF00071.17 ESA00885.1 - 0.002 17.5 0.2 0.006 15.9 0.2 1.8 1 0 0 1 1 1 1 Ras family LRR_4 PF12799.2 ESA00885.1 - 0.0039 16.7 23.4 0.016 14.8 4.7 4.7 3 1 2 5 5 5 2 Leucine Rich repeats (2 copies) DUF772 PF05598.6 ESA00885.1 - 0.0071 16.2 2.9 0.078 12.8 0.2 3.4 3 1 1 4 4 3 1 Transposase domain (DUF772) AAA_29 PF13555.1 ESA00885.1 - 0.0075 15.7 0.1 0.015 14.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 ESA00885.1 - 0.0089 16.3 0.1 0.0089 16.3 0.1 3.9 2 2 0 2 2 1 1 AAA domain PduV-EutP PF10662.4 ESA00885.1 - 0.013 14.9 0.0 0.041 13.3 0.0 1.9 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 ESA00885.1 - 0.016 14.0 0.3 0.047 12.5 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein LRR_8 PF13855.1 ESA00885.1 - 0.023 14.4 8.6 0.052 13.3 4.4 2.9 1 1 1 2 2 2 0 Leucine rich repeat AAA_16 PF13191.1 ESA00885.1 - 0.026 14.5 1.3 0.55 10.1 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.1 ESA00885.1 - 0.035 14.2 0.1 0.34 11.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain LRR_6 PF13516.1 ESA00885.1 - 0.042 13.9 7.3 0.039 14.0 0.9 3.7 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.28 ESA00885.1 - 0.13 12.3 6.0 0.5 10.5 0.5 3.5 2 0 0 2 2 2 0 Leucine Rich Repeat DUF1777 PF08648.7 ESA00885.1 - 0.44 10.2 2.5 7.6 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Myb_DNA-bind_4 PF13837.1 ESA00885.1 - 7.2 6.8 8.4 0.2 11.8 0.3 2.5 3 0 0 3 3 2 0 Myb/SANT-like DNA-binding domain AMP-binding PF00501.23 ESA00886.1 - 1.1e-36 126.1 0.0 1.4e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme dNK PF01712.14 ESA00888.1 - 0.092 12.6 2.6 0.1 12.4 1.8 1.1 1 0 0 1 1 1 0 Deoxynucleoside kinase Pkinase PF00069.20 ESA00891.1 - 5.7e-13 48.6 0.0 6.8e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00891.1 - 1e-09 37.8 0.0 1.2e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase HMG_box PF00505.14 ESA00893.1 - 7.3e-05 22.9 3.5 0.0002 21.5 2.4 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box GIT_SHD PF08518.6 ESA00894.1 - 0.0038 16.5 0.1 26 4.2 0.0 4.4 5 0 0 5 5 5 0 Spa2 homology domain (SHD) of GIT HMG_box PF00505.14 ESA00894.1 - 0.0077 16.4 1.3 0.019 15.2 0.9 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box IZUMO PF15005.1 ESA00894.1 - 0.041 13.9 0.1 6 6.9 0.0 3.1 1 1 2 3 3 3 0 Izumo sperm-egg fusion HTH_3 PF01381.17 ESA00894.1 - 0.069 13.0 0.1 16 5.4 0.0 3.9 4 1 1 5 5 5 0 Helix-turn-helix DUF4168 PF13767.1 ESA00894.1 - 0.3 11.7 24.4 0.78 10.4 3.1 4.9 1 1 5 6 6 6 0 Domain of unknown function (DUF4168) RAP PF08373.5 ESA00894.1 - 2.4 8.0 8.5 1.3e+02 2.5 0.0 5.2 5 1 1 6 6 6 0 RAP domain DUF1443 PF07280.6 ESA00895.1 - 3.5 7.2 17.1 2.7 7.6 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1443) DNA_pol_E_B PF04042.11 ESA00896.1 - 0.00014 21.2 0.0 0.13 11.4 0.0 2.9 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B A2L_zn_ribbon PF08792.5 ESA00896.1 - 0.00018 20.8 0.0 9.3 5.8 0.0 3.2 3 0 0 3 3 3 3 A2L zinc ribbon domain DUF3951 PF13131.1 ESA00896.1 - 0.0024 17.5 5.8 3.4 7.5 0.1 3.1 1 1 2 3 3 3 2 Protein of unknown function (DUF3951) Desmo_N PF06771.6 ESA00896.1 - 0.0026 17.6 0.0 0.78 9.7 0.0 2.1 2 0 0 2 2 2 2 Viral Desmoplakin N-terminus Ovate PF04844.8 ESA00896.1 - 0.0034 17.1 0.0 39 4.1 0.0 3.9 4 0 0 4 4 4 0 Transcriptional repressor, ovate OHA PF14418.1 ESA00896.1 - 0.0036 16.7 0.6 22 4.6 0.0 3.3 3 0 0 3 3 3 0 OST-HTH Associated domain TPR_16 PF13432.1 ESA00896.1 - 0.04 14.5 0.1 10 6.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc4_WD40 PF12894.2 ESA00896.1 - 0.07 12.6 0.0 85 2.7 0.0 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain HTH_10 PF04967.7 ESA00896.1 - 0.09 12.3 0.0 76 3.0 0.0 3.1 3 0 0 3 3 3 0 HTH DNA binding domain DUF3642 PF12182.3 ESA00896.1 - 0.4 11.1 2.1 66 4.0 0.4 3.1 2 1 1 3 3 3 0 Bacterial lipoprotein Arch_ATPase PF01637.13 ESA00900.1 - 1.5e-08 34.6 0.0 1.7e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA00900.1 - 2.9e-06 27.4 0.0 3.6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 ESA00900.1 - 0.023 14.4 0.2 0.25 11.1 0.0 2.0 1 1 1 2 2 2 0 Part of AAA domain AAA_28 PF13521.1 ESA00900.1 - 0.024 14.5 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESA00900.1 - 0.075 12.1 0.0 0.18 10.8 0.0 1.5 1 1 1 2 2 2 0 Zeta toxin Scramblase PF03803.10 ESA00901.1 - 7.6e-62 208.2 0.2 1.1e-61 207.7 0.1 1.2 1 0 0 1 1 1 1 Scramblase Bac_DnaA PF00308.13 ESA00901.1 - 0.052 13.1 0.8 0.13 11.8 0.3 1.8 2 1 0 2 2 2 0 Bacterial dnaA protein FCH PF00611.18 ESA00902.1 - 1.2e-19 70.3 0.4 1.2e-19 70.3 0.3 3.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.23 ESA00902.1 - 1.8e-14 52.8 0.0 3.5e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA00902.1 - 8.3e-13 47.7 0.4 1.9e-12 46.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 ESA00902.1 - 9.2e-11 41.0 0.0 1.8e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PTCB-BRCT PF12738.2 ESA00902.1 - 0.099 12.5 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 twin BRCT domain RecA PF00154.16 ESA00903.1 - 0.0057 15.7 0.0 0.0071 15.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein FKS1_dom1 PF14288.1 ESA00903.1 - 0.078 12.8 0.5 0.13 12.1 0.3 1.5 1 1 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Orn_Arg_deC_N PF02784.11 ESA00905.1 - 1.1e-77 260.6 0.0 1.5e-77 260.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 ESA00905.1 - 1.9e-30 104.9 0.0 4.4e-30 103.7 0.0 1.6 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Dimer_Tnp_hAT PF05699.9 ESA00906.1 - 1.8e-05 24.2 0.1 4.3e-05 23.0 0.1 1.8 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA00906.1 - 0.0018 18.2 0.6 0.011 15.7 0.2 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4413) Lipoprotein_X PF03305.8 ESA00906.1 - 0.041 13.2 0.1 0.068 12.5 0.1 1.3 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein ATP-synt_S1 PF05827.7 ESA00906.1 - 0.089 12.1 0.5 0.15 11.3 0.1 1.5 2 0 0 2 2 2 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Orbi_NS1 PF01718.11 ESA00907.1 - 0.01 13.8 0.3 0.016 13.2 0.2 1.2 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein NMD3 PF04981.8 ESA00907.1 - 0.012 14.7 0.3 0.025 13.7 0.2 1.6 1 0 0 1 1 1 0 NMD3 family YhfH PF14149.1 ESA00907.1 - 0.082 12.7 1.2 0.27 11.0 0.7 2.0 2 0 0 2 2 2 0 YhfH-like protein Aldedh PF00171.17 ESA00908.1 - 5e-157 522.9 0.0 5.7e-157 522.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESA00908.1 - 0.0059 15.8 0.1 0.032 13.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) DZR PF12773.2 ESA00909.1 - 0.08 12.7 3.4 0.13 12.1 0.5 2.1 2 0 0 2 2 2 0 Double zinc ribbon DUF3797 PF12677.2 ESA00909.1 - 0.11 12.1 3.4 1.2 8.7 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3797) Cript PF10235.4 ESA00909.1 - 0.15 12.3 0.3 0.15 12.3 0.2 2.4 3 0 0 3 3 3 0 Microtubule-associated protein CRIPT zf-ribbon_3 PF13248.1 ESA00909.1 - 0.2 10.9 7.2 0.097 11.9 2.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF4379 PF14311.1 ESA00909.1 - 0.43 10.4 3.8 1.1 9.1 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4379) zinc_ribbon_4 PF13717.1 ESA00909.1 - 0.48 10.1 6.0 1.4 8.6 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESA00909.1 - 0.92 9.1 6.1 1.9 8.1 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 ESA00909.1 - 2.9 8.0 7.5 2.7 8.0 1.7 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2_3 PF13878.1 ESA00909.1 - 2.9 7.5 6.0 6.9 6.3 0.8 3.3 2 1 1 3 3 3 0 zinc-finger of acetyl-transferase ESCO Pkinase PF00069.20 ESA00910.1 - 1.8e-37 128.9 0.4 3.4e-37 128.0 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00910.1 - 2.9e-37 128.1 0.0 4.1e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TMF_DNA_bd PF12329.3 ESA00911.1 - 0.012 15.4 23.9 0.012 15.4 16.6 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TcdA_TcdB_pore PF12920.2 ESA00911.1 - 0.12 10.2 4.7 0.17 9.7 3.3 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain NDUF_B5 PF09781.4 ESA00911.1 - 0.22 10.7 6.3 0.1 11.8 2.8 1.6 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF3373 PF11853.3 ESA00911.1 - 0.23 9.9 4.4 0.25 9.8 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) PIN_4 PF13638.1 ESA00911.1 - 0.41 10.7 5.7 0.6 10.2 3.9 1.3 1 0 0 1 1 1 0 PIN domain Propep_M14 PF02244.11 ESA00911.1 - 0.81 9.3 8.5 0.85 9.3 0.1 2.8 3 0 0 3 3 3 0 Carboxypeptidase activation peptide DivIC PF04977.10 ESA00911.1 - 1.7 8.1 19.3 0.39 10.2 2.1 3.1 1 1 2 3 3 3 0 Septum formation initiator CBF_beta PF02312.12 ESA00912.1 - 0.037 13.6 0.1 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 Core binding factor beta subunit NAD_Gly3P_dh_N PF01210.18 ESA00912.1 - 0.049 13.3 0.1 0.057 13.1 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus BTB PF00651.26 ESA00915.1 - 4.4e-10 39.5 0.4 0.00011 22.1 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA00915.1 - 0.0045 16.7 0.2 0.47 10.3 0.0 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch Glycohydro_20b2 PF14845.1 ESA00915.1 - 0.077 13.6 0.5 0.23 12.0 0.2 2.0 1 1 1 2 2 2 0 beta-acetyl hexosaminidase like BTB PF00651.26 ESA00916.1 - 3.8e-12 46.1 0.7 3e-10 40.0 0.5 2.5 1 1 0 1 1 1 1 BTB/POZ domain MATH PF00917.21 ESA00916.1 - 0.0013 18.9 0.1 0.0043 17.3 0.1 1.8 1 0 0 1 1 1 1 MATH domain BACK PF07707.10 ESA00916.1 - 0.0027 17.5 0.1 0.22 11.3 0.0 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA00917.1 - 2.4e-11 43.5 1.9 5.9e-05 23.0 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA00917.1 - 0.0033 17.2 0.2 0.12 12.1 0.0 2.8 1 1 0 2 2 2 1 BTB And C-terminal Kelch CENP-B_dimeris PF09026.5 ESA00917.1 - 2.7 8.3 10.7 4.9 7.4 7.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SWIM PF04434.12 ESA00919.1 - 0.0054 16.1 0.1 0.013 14.9 0.1 1.6 1 0 0 1 1 1 1 SWIM zinc finger DNA_pol_B PF00136.16 ESA00920.1 - 1.2e-120 403.4 1.6 2.3e-120 402.5 1.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESA00920.1 - 3.5e-41 141.1 1.9 6.5e-41 140.2 1.3 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.5 ESA00920.1 - 1.2e-35 122.5 3.2 2.8e-35 121.3 2.2 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger TAN PF11640.3 ESA00922.1 - 0.063 13.0 0.1 0.16 11.6 0.1 1.7 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair GST_N_3 PF13417.1 ESA00923.1 - 4.9e-14 52.2 0.0 1.2e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA00923.1 - 9.4e-11 41.7 0.0 1.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA00923.1 - 2.4e-07 30.6 0.0 3.6e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA00923.1 - 1.5e-06 28.0 0.0 2.2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA00923.1 - 0.00027 20.7 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.5 ESA00923.1 - 0.092 13.1 0.0 0.21 11.9 0.0 1.6 1 1 0 1 1 1 0 MetRS-N binding domain GST_N_3 PF13417.1 ESA00924.1 - 7.3e-14 51.7 0.0 1.7e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA00924.1 - 1e-13 51.0 0.0 1.7e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA00924.1 - 8.8e-12 45.0 0.0 1.4e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA00924.1 - 1.7e-08 34.2 0.0 2.7e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESA00924.1 - 1.5e-07 31.3 0.0 2.7e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain CortBP2 PF09727.4 ESA00925.1 - 0.02 14.3 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 Cortactin-binding protein-2 Luteo_coat PF00894.13 ESA00925.1 - 0.088 12.5 0.8 0.11 12.2 0.6 1.2 1 0 0 1 1 1 0 Luteovirus coat protein Complex1_LYR PF05347.10 ESA00926.1 - 6.3e-10 38.6 0.3 1.4e-09 37.5 0.2 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA00926.1 - 1e-06 28.8 0.3 1.6e-06 28.2 0.2 1.5 1 1 0 1 1 1 1 Complex1_LYR-like HSBP1 PF06825.7 ESA00927.1 - 3.6e-05 23.2 0.2 0.055 13.0 0.2 4.6 2 2 2 4 4 4 1 Heat shock factor binding protein 1 FlaC_arch PF05377.6 ESA00927.1 - 0.0019 18.0 1.9 0.0019 18.0 1.3 4.6 3 1 2 5 5 5 1 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.3 ESA00927.1 - 0.005 16.6 14.2 0.005 16.6 9.8 5.7 3 2 3 6 6 6 1 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.7 ESA00927.1 - 0.31 10.8 13.3 1.1 9.0 6.2 2.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 ESA00927.1 - 0.4 9.8 5.8 1.2 8.2 0.8 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein MobC PF05713.6 ESA00927.1 - 0.72 9.8 0.1 0.72 9.8 0.0 3.3 4 0 0 4 4 4 0 Bacterial mobilisation protein (MobC) Mago_nashi PF02792.9 ESA00927.1 - 0.85 9.3 6.7 0.99 9.0 3.5 1.9 1 1 0 1 1 1 0 Mago nashi protein MtrG PF04210.8 ESA00927.1 - 1.1 8.9 3.8 1.3 8.7 0.5 2.7 1 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G V_ATPase_I PF01496.14 ESA00927.1 - 1.4 6.6 34.3 0.016 13.0 13.7 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family PilJ PF13675.1 ESA00927.1 - 1.5 9.1 5.5 6.5 7.1 1.6 2.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term HalX PF08663.5 ESA00927.1 - 2.3 8.2 7.8 1.7 8.7 0.2 3.5 3 0 0 3 3 3 0 HalX domain Toprim_Crpt PF13342.1 ESA00927.1 - 3.5 7.3 11.9 0.35 10.5 0.3 3.5 4 0 0 4 4 4 0 C-terminal repeat of topoisomerase Allexi_40kDa PF05549.6 ESA00927.1 - 7.9 5.6 18.8 1.7 7.8 6.5 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein Atg14 PF10186.4 ESA00927.1 - 9.7 5.0 33.3 4e+02 -0.3 22.8 2.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_24 PF13479.1 ESA00928.1 - 3.4e-05 23.5 0.0 3.9e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 ESA00928.1 - 0.0011 19.3 0.0 0.0013 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA00928.1 - 0.0016 18.4 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain YccV-like PF08755.6 ESA00928.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 Hemimethylated DNA-binding protein YccV like HTH_AsnC-type PF13404.1 ESA00928.1 - 0.042 13.3 0.1 4.1 7.0 0.1 2.7 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain AAA_22 PF13401.1 ESA00928.1 - 0.088 12.9 0.2 0.13 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESA00928.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase AAA_29 PF13555.1 ESA00928.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 ESA00928.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESA00928.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain Polysacc_synt PF01943.12 ESA00929.1 - 0.0094 15.2 0.8 0.0094 15.2 0.6 2.3 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein DUF1703 PF08011.6 ESA00929.1 - 0.094 12.4 0.2 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1703) Serpentine_r_xa PF03383.10 ESA00929.1 - 3 7.5 9.9 0.35 10.6 1.7 2.1 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa DUF758 PF05527.6 ESA00931.1 - 0.031 13.8 0.3 0.077 12.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF758) TauD PF02668.11 ESA00931.1 - 0.052 13.2 0.4 0.085 12.5 0.3 1.3 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family MPC PF03650.8 ESA00931.1 - 0.063 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0041) LMF1 PF06762.9 ESA00932.1 - 0.31 9.7 6.1 0.35 9.6 4.2 1.1 1 0 0 1 1 1 0 Lipase maturation factor DICT PF10069.4 ESA00933.1 - 0.067 12.7 0.4 0.11 11.9 0.3 1.4 1 0 0 1 1 1 0 Sensory domain found in DIguanylate Cyclases & Two-component systems DUF2215 PF10225.4 ESA00935.1 - 2.6 7.4 6.6 0.19 11.1 1.3 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) DUF2362 PF10154.4 ESA00936.1 - 5.1e-73 246.4 16.5 5.2e-36 124.3 0.4 3.2 2 1 1 3 3 3 3 Uncharacterized conserved protein (DUF2362) UBA PF00627.26 ESA00936.1 - 1.2e-07 31.3 1.5 2.5e-07 30.3 1.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 ESA00936.1 - 0.025 14.1 0.1 0.057 12.9 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain ETX_MTX2 PF03318.8 ESA00938.1 - 0.0027 17.2 9.0 0.0045 16.5 5.9 1.5 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 DUF2418 PF10332.4 ESA00938.1 - 0.014 15.7 1.6 0.19 12.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) Mucin PF01456.12 ESA00939.1 - 0.1 12.4 29.6 0.15 11.8 20.5 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MSP1_C PF07462.6 ESA00939.1 - 0.2 9.9 6.5 0.22 9.8 4.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Sporozoite_P67 PF05642.6 ESA00939.1 - 0.81 7.4 8.1 0.97 7.2 5.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tir_receptor_N PF07490.6 ESA00939.1 - 2.4 7.7 11.9 3 7.4 8.2 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus Med3 PF11593.3 ESA00939.1 - 2.9 7.0 23.3 3.6 6.7 16.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ead_Ea22 PF13935.1 ESA00941.1 - 0.096 13.0 0.0 0.25 11.6 0.0 1.7 1 1 1 2 2 2 0 Ead/Ea22-like protein Myb_DNA-binding PF00249.26 ESA00942.1 - 9.9e-06 25.5 2.0 0.066 13.2 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Seadorna_VP7 PF07387.6 ESA00942.1 - 0.075 11.8 0.3 0.17 10.7 0.1 1.5 1 1 1 2 2 2 0 Seadornavirus VP7 Lenti_VIF_2 PF07401.7 ESA00942.1 - 0.12 11.4 1.8 0.23 10.5 0.3 2.0 1 1 1 2 2 2 0 Bovine Lentivirus VIF protein Myb_DNA-bind_6 PF13921.1 ESA00942.1 - 0.13 12.3 6.8 1.6 8.9 0.1 2.6 1 1 2 3 3 3 0 Myb-like DNA-binding domain Na_Ca_ex PF01699.19 ESA00943.1 - 4.2e-47 159.2 28.3 8.8e-24 83.7 3.9 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF1510 PF07423.6 ESA00943.1 - 0.14 11.5 0.0 0.42 9.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pkinase_Tyr PF07714.12 ESA00944.1 - 3.3e-39 134.5 0.2 6.2e-39 133.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00944.1 - 1.3e-35 122.8 0.5 2.9e-35 121.6 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA00944.1 - 3.5e-10 40.1 1.4 8.1e-08 32.6 0.0 3.7 3 0 0 3 3 3 1 Sel1 repeat Phage_GPO PF05929.6 ESA00944.1 - 0.0073 15.5 2.4 0.014 14.6 1.7 1.5 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase DUF4559 PF15112.1 ESA00944.1 - 0.015 14.5 6.6 0.027 13.6 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Acetate_kinase PF00871.12 ESA00944.1 - 0.07 11.6 1.5 0.12 10.9 0.5 1.7 1 1 1 2 2 2 0 Acetokinase family SCF PF02404.10 ESA00944.1 - 0.071 12.2 5.2 0.039 13.1 1.8 1.8 1 1 1 2 2 2 0 Stem cell factor TPR_11 PF13414.1 ESA00944.1 - 0.12 11.9 2.2 17 5.1 0.0 3.2 3 0 0 3 3 3 0 TPR repeat CHD5 PF04420.9 ESA00944.1 - 10 5.7 8.3 11 5.7 1.9 2.4 2 0 0 2 2 2 0 CHD5-like protein DMAP_binding PF06464.6 ESA00945.1 - 0.07 13.7 0.1 0.12 12.9 0.1 1.4 1 0 0 1 1 1 0 DMAP1-binding Domain DUF4523 PF15023.1 ESA00946.1 - 0.13 11.7 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Pkinase_Tyr PF07714.12 ESA00947.1 - 3.3e-35 121.4 0.1 5.7e-35 120.6 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00947.1 - 2.4e-29 102.2 0.3 4.6e-29 101.3 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA00947.1 - 2.6e-09 37.4 3.7 2.7e-06 27.8 0.1 4.1 4 0 0 4 4 4 2 Sel1 repeat Glyco_hydro_108 PF05838.7 ESA00948.1 - 0.065 13.3 0.2 12 6.0 0.0 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase 108 Rota_NSP3 PF01665.11 ESA00948.1 - 0.082 11.8 6.2 0.067 12.1 1.2 2.0 2 0 0 2 2 2 0 Rotavirus non-structural protein NSP3 zf-UBR PF02207.15 ESA00948.1 - 2.2 8.0 9.8 3.8 7.2 1.2 2.2 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) DUF390 PF04094.9 ESA00949.1 - 0.011 13.8 3.1 0.014 13.4 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) DBR1 PF05011.8 ESA00949.1 - 0.018 14.9 1.7 0.05 13.4 1.2 1.8 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain Tox-PLDMTX PF15645.1 ESA00950.1 - 0.14 12.1 0.6 0.14 12.1 0.4 1.1 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold DUF972 PF06156.8 ESA00950.1 - 0.72 10.2 3.9 0.79 10.0 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) FYRC PF05965.9 ESA00952.1 - 0.0052 16.5 0.0 7 6.5 0.0 3.1 2 1 0 2 2 2 2 F/Y rich C-terminus Mito_carr PF00153.22 ESA00953.1 - 2.9e-69 228.8 2.5 3.6e-23 81.0 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LAM_C PF12544.3 ESA00954.1 - 0.27 11.2 2.7 2.3 8.2 1.9 2.0 1 1 0 1 1 1 0 Lysine-2,3-aminomutase Abhydrolase_5 PF12695.2 ESA00955.1 - 9.1e-09 35.2 0.0 1.2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.7 ESA00955.1 - 2.2e-06 27.5 0.1 1.6e-05 24.7 0.0 2.0 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.2 ESA00955.1 - 3e-05 24.0 0.0 0.0082 16.0 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA00955.1 - 0.0022 17.4 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.8 ESA00955.1 - 0.0039 16.6 0.1 0.031 13.7 0.0 2.2 1 1 1 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 ESA00955.1 - 0.15 11.2 0.3 9.4 5.3 0.0 2.2 1 1 1 2 2 2 0 Prolyl oligopeptidase family UQ_con PF00179.21 ESA00956.1 - 2.3e-46 156.7 0.0 2.9e-46 156.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA00956.1 - 1.5e-05 24.8 0.0 2.1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA00956.1 - 0.0017 18.1 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA00956.1 - 0.019 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 UEV domain Cupin_8 PF13621.1 ESA00957.1 - 1.3e-25 90.3 0.6 9.2e-25 87.5 0.4 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 ESA00957.1 - 5.7e-11 42.6 0.1 1.5e-10 41.2 0.1 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box PF00646.28 ESA00957.1 - 0.0023 17.5 0.3 0.0054 16.3 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA00957.1 - 0.067 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 F-box-like Sec8_exocyst PF04048.9 ESA00960.1 - 1.6e-44 150.9 0.1 6.8e-44 148.9 0.1 2.2 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF2450 PF10475.4 ESA00960.1 - 6.4e-07 28.5 1.0 1.8e-06 27.1 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) Pox_Ag35 PF03286.9 ESA00961.1 - 0.2 11.1 15.3 0.36 10.3 10.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pox_RNA_Pol_19 PF05320.7 ESA00961.1 - 0.47 10.1 12.4 0.87 9.3 8.6 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Secretin_N_2 PF07655.8 ESA00961.1 - 1.3 9.4 10.3 3.2 8.2 7.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Nop14 PF04147.7 ESA00961.1 - 6.6 4.5 14.4 11 3.7 10.0 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA00961.1 - 9.4 4.1 12.0 14 3.6 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DnaJ PF00226.26 ESA00962.1 - 9.4e-18 63.7 2.4 1.3e-17 63.2 0.4 2.2 2 0 0 2 2 2 1 DnaJ domain DUF3095 PF11294.3 ESA00962.1 - 0.064 12.2 2.6 0.08 11.9 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) Selenoprotein_S PF06936.6 ESA00962.1 - 0.07 12.6 7.1 0.099 12.1 4.9 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) GAGA_bind PF06217.7 ESA00962.1 - 0.92 9.4 10.1 1.1 9.1 7.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2570 PF10828.3 ESA00962.1 - 1.5 8.4 10.8 0.45 10.1 5.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Peptidase_M1 PF01433.15 ESA00963.1 - 3.6e-10 39.5 0.0 0.00024 20.3 0.0 2.3 2 0 0 2 2 2 2 Peptidase family M1 HEAT_2 PF13646.1 ESA00963.1 - 0.045 14.0 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 HEAT repeats P34-Arc PF04045.9 ESA00964.1 - 1.2e-105 352.1 1.8 1.5e-105 351.8 1.2 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc GTP_EFTU PF00009.22 ESA00965.1 - 4.7e-61 205.5 0.7 6.8e-61 204.9 0.5 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESA00965.1 - 6.2e-31 106.5 0.3 3.4e-30 104.1 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESA00965.1 - 6.7e-17 61.3 1.9 1.9e-16 59.9 1.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA00965.1 - 8.2e-06 25.7 0.0 1.6e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESA00965.1 - 0.00043 20.7 0.0 0.00072 20.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein cobW PF02492.14 ESA00965.1 - 0.00089 18.7 0.4 0.0027 17.1 0.0 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ESA00965.1 - 0.031 13.7 0.2 6.7 6.1 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation CbiA PF01656.18 ESA00965.1 - 0.054 12.9 2.6 5.1 6.4 0.0 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DNA_ligase_A_M PF01068.16 ESA00967.1 - 2e-51 174.2 3.3 6.4e-50 169.3 1.4 2.9 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 ESA00967.1 - 9.4e-44 149.3 0.0 2e-43 148.2 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 ESA00967.1 - 2.2e-20 72.8 0.0 5.5e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.14 ESA00967.1 - 0.0033 17.1 0.4 0.035 13.8 0.0 2.2 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain DUF3091 PF11291.3 ESA00969.1 - 0.69 9.9 5.0 12 5.9 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3091) DUF2536 PF10750.4 ESA00969.1 - 2.8 7.5 6.3 0.61 9.7 1.6 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2536) DUF4163 PF13739.1 ESA00969.1 - 3.3 8.5 6.7 4.6 8.0 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4163) Sel1 PF08238.7 ESA00970.1 - 6.1e-47 157.0 24.4 5.1e-13 49.1 0.1 5.1 5 0 0 5 5 5 4 Sel1 repeat TPR_17 PF13431.1 ESA00970.1 - 1.5e-05 24.8 16.9 0.91 9.8 0.1 5.9 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00970.1 - 3.2e-05 24.0 12.0 0.13 12.7 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.13 ESA00970.1 - 0.0011 18.8 6.3 1.6 8.7 0.1 3.5 2 1 1 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA00970.1 - 0.0083 15.7 4.2 0.0083 15.7 2.9 4.4 1 1 2 3 3 3 1 TPR repeat TPR_14 PF13428.1 ESA00970.1 - 0.025 15.1 0.2 8.6 7.3 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA00970.1 - 0.06 13.2 10.9 0.19 11.6 0.8 4.3 2 1 2 4 4 4 0 Tetratricopeptide repeat PaRep2b PF07775.6 ESA00970.1 - 0.88 7.7 9.7 2.7 6.1 0.1 3.1 1 1 1 3 3 3 0 PaRep2b protein TOM20_plant PF06552.7 ESA00970.1 - 1.1 8.7 7.5 7.8 6.0 0.3 3.1 1 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 HTH_16 PF12645.2 ESA00970.1 - 1.7 8.5 4.7 18 5.3 0.0 3.5 4 0 0 4 4 4 0 Helix-turn-helix domain DUF3830 PF12903.2 ESA00970.1 - 2 7.7 8.2 37 3.6 0.5 4.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3830) Sel1 PF08238.7 ESA00971.1 - 1.4e-44 149.5 15.7 1.1e-10 41.7 0.4 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_20 PF14561.1 ESA00971.1 - 0.0027 17.8 0.0 0.031 14.3 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat EF-hand_10 PF14788.1 ESA00971.1 - 0.026 14.1 0.6 5 6.8 0.0 3.3 4 0 0 4 4 4 0 EF hand Sel1 PF08238.7 ESA00972.1 - 1e-24 86.3 3.6 2.2e-10 40.8 0.1 3.1 3 0 0 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA00972.1 - 0.059 13.2 4.6 0.91 9.4 0.4 2.8 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESA00972.1 - 0.12 13.1 0.1 25 5.7 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA00972.1 - 0.36 10.5 3.5 2.2 7.9 0.6 2.7 1 1 2 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESA00972.1 - 4.5 7.4 10.5 3.2 7.9 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA00972.1 - 8.9 6.1 9.0 2.5 7.8 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3667 PF12412.3 ESA00973.1 - 0.055 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) Cauli_AT PF03233.8 ESA00974.1 - 0.063 12.9 0.0 0.068 12.8 0.0 1.0 1 0 0 1 1 1 0 Aphid transmission protein BTB PF00651.26 ESA00975.1 - 6.3e-18 64.7 1.3 9.9e-18 64.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA00975.1 - 1.7e-11 44.2 4.4 3.4e-11 43.2 3.1 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA00975.1 - 1.7e-07 30.9 1.7 2.7e-06 27.1 0.3 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF4040 PF13244.1 ESA00977.1 - 0.29 11.1 6.0 0.18 11.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4040) PDEase_I PF00233.14 ESA00978.1 - 2.4e-56 191.1 0.0 5.2e-52 176.9 0.0 2.1 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.19 ESA00978.1 - 0.005 16.8 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain PAZ_siRNAbind PF12212.3 ESA00979.1 - 0.091 12.4 0.3 0.82 9.3 0.0 2.3 3 0 0 3 3 3 0 Piwi/Argonaute/Zwille siRNA-binding domain F-box-like PF12937.2 ESA00980.1 - 3.5e-05 23.4 0.1 0.0003 20.4 0.0 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA00980.1 - 0.057 13.1 1.0 0.23 11.1 0.1 2.6 3 0 0 3 3 3 0 F-box domain Stn1 PF10451.4 ESA00981.1 - 9.4e-12 44.3 1.1 1.3e-11 43.8 0.7 1.3 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.20 ESA00981.1 - 1.3e-05 25.0 0.3 4.6e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Asn_synthase PF00733.16 ESA00981.1 - 0.089 12.2 0.0 0.42 10.0 0.0 2.0 2 0 0 2 2 2 0 Asparagine synthase AATF-Che1 PF13339.1 ESA00982.1 - 2.2e-30 105.5 0.6 2.2e-30 105.5 0.4 4.2 3 1 1 4 4 4 1 Apoptosis antagonizing transcription factor TRAUB PF08164.7 ESA00982.1 - 1.2e-28 99.0 0.0 1.2e-28 99.0 0.0 3.3 4 0 0 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal Transketolase_N PF00456.16 ESA00983.1 - 1.1e-144 481.3 0.0 1.4e-144 480.9 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 ESA00983.1 - 3.7e-45 153.5 0.0 1.1e-44 151.9 0.0 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESA00983.1 - 1.4e-09 37.9 0.0 3.8e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.1 ESA00983.1 - 1.4e-06 27.4 0.1 0.00061 18.8 0.0 2.5 2 1 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 ESA00983.1 - 0.034 13.7 0.3 0.26 10.8 0.2 2.3 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain WD40 PF00400.27 ESA00984.1 - 2.2e-80 261.9 27.2 1.2e-14 53.5 0.2 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA00984.1 - 7.3e-06 24.3 7.6 0.76 7.8 0.1 5.3 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA00984.1 - 7.5e-06 24.9 3.7 0.83 8.3 0.4 4.7 2 2 2 4 4 4 3 Nup133 N terminal like eIF2A PF08662.6 ESA00984.1 - 6.2e-05 22.7 0.6 0.026 14.2 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A LisH PF08513.6 ESA00984.1 - 0.069 12.9 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 LisH Myb_DNA-binding PF00249.26 ESA00985.1 - 2.7e-05 24.1 0.1 4.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA00985.1 - 0.021 14.8 0.1 0.059 13.4 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain BTB PF00651.26 ESA00986.1 - 1.3e-06 28.3 0.0 1.4e-05 24.9 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA00986.1 - 0.12 12.1 0.5 0.24 11.2 0.1 1.7 2 0 0 2 2 2 0 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA00987.1 - 8.8e-37 126.5 0.8 2e-36 125.4 0.6 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00987.1 - 8.6e-31 107.0 2.6 8.6e-31 107.0 1.8 1.8 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA00987.1 - 2.4e-08 34.3 5.6 3.6e-06 27.4 0.0 3.5 4 0 0 4 4 4 2 Sel1 repeat ParBc PF02195.13 ESA00988.1 - 0.11 12.6 1.0 0.23 11.6 0.5 1.9 1 1 0 1 1 1 0 ParB-like nuclease domain Pkinase_Tyr PF07714.12 ESA00989.1 - 1.2e-35 122.7 0.2 1.9e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00989.1 - 1e-28 100.2 0.4 1.4e-28 99.7 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA00991.1 - 3.4e-20 72.2 0.0 4e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA00991.1 - 1.3e-19 70.3 0.0 1.5e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA00992.1 - 4.1e-35 121.1 0.6 6.6e-35 120.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA00992.1 - 1e-32 113.3 0.1 1e-32 113.3 0.1 2.2 2 1 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA00992.1 - 1.1e-07 32.1 6.4 9.9e-07 29.2 0.0 3.8 4 0 0 4 4 4 1 Sel1 repeat Sel1 PF08238.7 ESA00993.1 - 3.4e-64 211.8 34.8 3.9e-13 49.5 0.3 7.0 7 0 0 7 7 7 7 Sel1 repeat TPR_17 PF13431.1 ESA00993.1 - 3e-05 23.8 19.3 0.33 11.2 0.1 6.9 5 1 1 6 6 6 2 Tetratricopeptide repeat MIT PF04212.13 ESA00993.1 - 0.00049 19.9 20.3 1.8 8.5 0.3 5.4 6 0 0 6 6 6 4 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA00993.1 - 0.0008 19.0 3.1 24 4.7 0.0 4.4 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_12 PF13424.1 ESA00993.1 - 0.0012 18.6 17.8 0.15 12.0 2.5 4.2 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESA00993.1 - 0.0094 16.3 13.4 1.3 9.6 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF1268 PF06896.6 ESA00993.1 - 0.26 11.6 5.1 15 5.9 0.1 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1268) TPR_20 PF14561.1 ESA00993.1 - 1.3 9.2 4.2 17 5.6 0.4 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 ESA00993.1 - 1.6 8.8 11.5 18 5.4 0.3 4.0 3 1 1 4 4 4 0 Rapamycin binding domain DNA_pol_E_B PF04042.11 ESA00995.1 - 1.8e-48 164.5 0.1 2.6e-48 164.0 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PI3_PI4_kinase PF00454.22 ESA00997.1 - 2e-35 122.3 0.6 2e-35 122.3 0.4 1.7 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.1 ESA00997.1 - 0.13 11.2 0.0 0.13 11.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) Pik1 PF11522.3 ESA00998.1 - 7.8e-12 44.7 0.0 1.9e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 ESA00998.1 - 4.9e-06 25.8 0.1 7.5e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) BCAS2 PF05700.6 ESA00999.1 - 1.3e-62 211.1 14.7 1.5e-62 210.9 10.2 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Use1 PF09753.4 ESA00999.1 - 0.00066 19.1 5.4 0.00079 18.9 3.3 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF1140 PF06600.6 ESA00999.1 - 0.44 10.7 7.7 0.12 12.5 2.9 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1140) XkdW PF09636.5 ESA00999.1 - 0.79 9.6 8.8 0.26 11.1 2.5 2.3 2 0 0 2 2 2 0 XkdW protein DUF4337 PF14235.1 ESA00999.1 - 2 8.2 7.6 1 9.1 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) ATP-synt_C PF00137.16 ESA01000.1 - 1.1e-30 105.3 31.1 2.5e-19 68.9 3.9 2.1 2 0 0 2 2 2 2 ATP synthase subunit C GerA PF03323.8 ESA01000.1 - 8.1 4.4 6.0 1.1 7.3 0.3 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Snapin_Pallidin PF14712.1 ESA01001.1 - 6.9e-16 58.3 3.4 6.9e-16 58.3 2.3 2.0 2 0 0 2 2 2 1 Snapin/Pallidin Adeno_PVIII PF01310.13 ESA01001.1 - 0.14 11.9 3.1 0.15 11.8 0.8 1.8 1 1 1 2 2 2 0 Adenovirus hexon associated protein, protein VIII G-7-MTase PF12803.2 ESA01001.1 - 0.75 8.8 7.2 0.92 8.5 5.0 1.1 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) SlyX PF04102.7 ESA01001.1 - 0.8 10.1 8.9 5.4 7.4 1.5 2.4 2 0 0 2 2 2 0 SlyX GAGA_bind PF06217.7 ESA01001.1 - 2.3 8.0 8.2 3.2 7.6 5.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family YlqD PF11068.3 ESA01001.1 - 2.8 7.9 13.0 1.3 9.0 6.8 1.9 1 1 1 2 2 2 0 YlqD protein Acetyltransf_1 PF00583.19 ESA01002.1 - 2.6e-14 52.9 0.0 3.8e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA01002.1 - 3.2e-11 43.2 0.1 4.3e-11 42.8 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA01002.1 - 8.2e-06 26.0 0.1 2.1e-05 24.7 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA01002.1 - 0.00018 21.6 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA01002.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-RING_5 PF14634.1 ESA01005.1 - 1e-10 41.1 10.2 2.1e-10 40.1 7.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA01005.1 - 1.4e-05 24.6 8.7 2.8e-05 23.6 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA01005.1 - 5.2e-05 23.1 7.6 0.00012 22.0 5.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA01005.1 - 0.00015 21.5 9.1 0.00028 20.6 6.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA01005.1 - 0.00016 21.3 9.3 0.0003 20.3 6.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA01005.1 - 0.00045 20.0 4.4 0.00045 20.0 3.1 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA01005.1 - 0.0031 17.2 2.8 0.0031 17.2 2.0 3.0 3 1 1 4 4 3 1 RING-type zinc-finger Prok-RING_4 PF14447.1 ESA01005.1 - 0.026 14.0 5.3 0.24 10.9 0.1 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 V_ATPase_I PF01496.14 ESA01005.1 - 0.027 12.3 1.4 0.036 11.9 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Herpes_BLRF2 PF05812.7 ESA01005.1 - 0.03 14.1 4.1 0.046 13.5 2.4 1.6 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein DUF972 PF06156.8 ESA01005.1 - 0.043 14.1 1.9 0.096 13.0 1.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 ESA01005.1 - 0.12 11.9 0.3 0.22 11.1 0.2 1.5 1 0 0 1 1 1 0 IncA protein zf-4CXXC_R1 PF10497.4 ESA01005.1 - 0.17 12.0 4.2 0.37 10.9 2.9 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RING_4 PF14570.1 ESA01005.1 - 0.62 9.6 5.3 1.6 8.3 3.6 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain G-gamma PF00631.17 ESA01005.1 - 0.69 9.7 4.0 4.1 7.2 0.1 2.4 1 1 1 2 2 2 0 GGL domain TPR_MLP1_2 PF07926.7 ESA01005.1 - 0.9 9.2 11.0 1.7 8.3 7.6 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein CMV_1a PF12467.3 ESA01005.1 - 1.3 9.3 6.1 1.3 9.4 0.2 2.2 1 1 1 2 2 2 0 Cucumber mosaic virus 1a protein family DUF2296 PF10058.4 ESA01005.1 - 1.6 8.5 6.5 0.93 9.2 3.2 1.7 1 1 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) FYVE PF01363.16 ESA01005.1 - 7.1 6.6 12.0 25 4.8 8.3 1.9 1 1 0 1 1 1 0 FYVE zinc finger tRNA-synt_1 PF00133.17 ESA01006.1 - 1e-213 710.7 0.0 9.6e-213 707.5 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESA01006.1 - 3.1e-37 127.7 1.3 7.7e-37 126.4 0.9 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESA01006.1 - 8.3e-16 57.6 0.1 2.8e-06 26.2 0.0 4.7 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 ESA01006.1 - 1.2e-11 44.2 6.5 2.4e-09 36.7 0.0 3.3 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 ESA01006.1 - 3.8e-10 39.7 0.8 3.8e-10 39.7 0.5 3.6 3 1 1 4 4 4 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1d PF00750.14 ESA01006.1 - 0.013 14.3 0.1 0.084 11.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (R) tRNA-synt_1e PF01406.14 ESA01006.1 - 0.043 12.9 0.0 0.043 12.9 0.0 4.1 5 1 0 5 5 5 0 tRNA synthetases class I (C) catalytic domain ProRS-C_1 PF09180.6 ESA01007.1 - 4.5e-24 84.1 0.4 1.2e-23 82.8 0.3 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 ESA01007.1 - 4.1e-21 75.3 0.4 8.6e-21 74.2 0.3 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA01007.1 - 3.1e-16 59.0 0.2 2.8e-15 56.0 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain His_Phos_2 PF00328.17 ESA01008.1 - 6.7e-68 229.5 0.4 8.6e-68 229.2 0.3 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 ESA01008.1 - 1.1e-06 28.2 0.0 2.1e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 ESA01008.1 - 0.019 14.8 0.1 0.08 12.8 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain AAA_23 PF13476.1 ESA01009.1 - 0.015 15.6 3.0 0.016 15.5 2.1 1.1 1 0 0 1 1 1 0 AAA domain DUF2120 PF09893.4 ESA01009.1 - 0.034 14.0 2.8 0.049 13.5 1.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DGOK PF05035.7 ESA01010.1 - 0.0068 15.1 0.0 0.0068 15.1 0.0 1.0 1 0 0 1 1 1 1 2-keto-3-deoxy-galactonokinase F-box-like PF12937.2 ESA01011.1 - 0.033 13.8 0.2 0.1 12.3 0.1 1.8 1 0 0 1 1 1 0 F-box-like Sel1 PF08238.7 ESA01012.1 - 9.9e-21 73.7 12.0 1.5e-08 34.9 0.4 3.0 2 1 1 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA01012.1 - 0.0039 17.0 1.6 1.9 8.4 0.1 2.3 2 1 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA01012.1 - 0.0076 16.6 1.6 0.99 10.0 0.5 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat CEP1-DNA_bind PF09287.5 ESA01012.1 - 0.11 11.8 0.1 2.3 7.6 0.0 1.9 1 1 1 2 2 2 0 CEP-1, DNA binding MRP-L46 PF11788.3 ESA01012.1 - 0.48 11.0 3.8 10 6.8 0.2 2.1 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 TPR_17 PF13431.1 ESA01012.1 - 1 9.7 6.6 8 6.9 1.9 3.5 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA01012.1 - 8.6 6.5 11.3 12 6.0 0.1 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4561 PF15120.1 ESA01013.1 - 0.021 14.3 0.3 0.044 13.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4561) zf-C4pol PF14260.1 ESA01013.1 - 0.1 12.6 2.8 0.28 11.1 2.0 1.7 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta BRICHOS PF04089.9 ESA01014.1 - 0.12 12.2 0.1 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 BRICHOS domain Nucleic_acid_bd PF13820.1 ESA01015.1 - 0.014 14.9 1.1 0.21 11.1 0.2 2.6 2 1 0 2 2 2 0 Putative nucleic acid-binding region DUF4414 PF14377.1 ESA01015.1 - 0.022 14.6 0.1 0.022 14.6 0.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4414) Myb_DNA-binding PF00249.26 ESA01016.1 - 5e-14 52.0 2.1 2.4e-10 40.3 0.8 2.4 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA01016.1 - 1.2e-13 50.8 2.2 3.1e-10 39.9 0.3 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain Ribonuclease_3 PF00636.21 ESA01017.1 - 2.1e-05 24.9 1.3 4.2e-05 23.9 0.9 1.6 1 1 0 1 1 1 1 Ribonuclease III domain DUF1676 PF07898.8 ESA01017.1 - 0.03 14.6 0.8 0.084 13.1 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) Ribonucleas_3_3 PF14622.1 ESA01017.1 - 0.047 13.6 0.1 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 Ribonuclease-III-like RNase_H PF00075.19 ESA01018.1 - 2.7e-08 34.2 0.4 6.6e-08 32.9 0.3 1.6 1 0 0 1 1 1 1 RNase H DUF4239 PF14023.1 ESA01018.1 - 0.0023 17.3 2.2 0.0047 16.3 0.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF4239) RVT_1 PF00078.22 ESA01019.1 - 0.00017 21.0 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Yopt PF09467.5 ESA01019.1 - 0.0077 16.0 1.6 0.023 14.5 0.6 2.1 2 0 0 2 2 2 1 Hypothetical protein Yopt DNA_pol_B_3 PF08408.5 ESA01019.1 - 0.77 9.6 6.9 0.11 12.3 1.0 2.0 1 1 1 2 2 2 0 DNA polymerase family B viral insert Exo_endo_phos PF03372.18 ESA01020.1 - 9.9e-14 51.8 0.0 1.5e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA01020.1 - 2.5e-09 36.7 2.2 6.2e-09 35.5 1.6 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Unstab_antitox PF09720.5 ESA01020.1 - 0.074 12.7 0.2 1.4 8.6 0.0 2.8 2 0 0 2 2 2 0 Putative addiction module component zf-CCHC PF00098.18 ESA01021.1 - 0.0024 17.7 2.4 0.0044 16.8 1.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA01021.1 - 0.0038 16.6 1.5 0.0074 15.7 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle RRM_1 PF00076.17 ESA01021.1 - 0.021 14.4 0.1 0.2 11.3 0.1 2.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_4 PF14392.1 ESA01021.1 - 0.13 11.9 1.4 0.33 10.6 1.0 1.7 1 0 0 1 1 1 0 Zinc knuckle YmgB PF10798.3 ESA01023.1 - 0.091 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR DUF4379 PF14311.1 ESA01024.1 - 3.5e-07 29.9 21.9 0.0025 17.5 0.3 3.3 3 0 0 3 3 3 3 Domain of unknown function (DUF4379) Ricin_B_lectin PF00652.17 ESA01024.1 - 0.0088 16.0 6.9 0.15 12.0 2.8 2.9 2 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain HMA PF00403.21 ESA01024.1 - 0.13 12.4 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Heavy-metal-associated domain Jiv90 PF14901.1 ESA01024.1 - 0.13 12.3 6.4 2.2 8.2 0.2 3.2 3 0 0 3 3 3 0 Cleavage inducing molecular chaperone zf-CW PF07496.10 ESA01024.1 - 2.9 7.6 8.2 9.1 6.0 0.2 3.3 3 0 0 3 3 3 0 CW-type Zinc Finger Uma2 PF05685.7 ESA01025.1 - 6.3e-11 41.9 0.1 9.6e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-Di19 PF05605.7 ESA01025.1 - 0.0065 16.5 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding YL1 PF05764.8 ESA01025.1 - 0.0085 15.7 7.4 0.0085 15.7 5.1 1.9 2 0 0 2 2 2 1 YL1 nuclear protein zf-C2H2_4 PF13894.1 ESA01025.1 - 0.041 14.2 0.1 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA01025.1 - 0.056 13.8 0.2 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type CDC45 PF02724.9 ESA01025.1 - 0.11 10.4 7.5 0.15 10.0 5.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.20 ESA01026.1 - 1.4e-32 112.8 0.0 1.3e-31 109.6 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01026.1 - 7.4e-32 110.4 0.0 3.8e-31 108.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA01026.1 - 0.0045 16.2 0.0 0.0092 15.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA01026.1 - 0.014 14.7 0.0 0.036 13.4 0.0 1.7 2 0 0 2 2 2 0 RIO1 family APH PF01636.18 ESA01026.1 - 0.016 14.9 0.1 0.027 14.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA01027.1 - 0.00015 21.4 0.5 0.00036 20.1 0.3 1.6 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.20 ESA01028.1 - 4.8e-24 84.8 0.0 5.4e-24 84.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01028.1 - 2.3e-23 82.6 0.0 2.5e-23 82.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA01028.1 - 0.0016 17.6 0.2 0.0029 16.8 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) PsbU PF06514.6 ESA01028.1 - 0.014 15.2 0.2 0.029 14.1 0.1 1.6 1 1 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) APH PF01636.18 ESA01028.1 - 0.038 13.7 0.1 0.089 12.5 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family TFIIF_beta PF02270.10 ESA01029.1 - 1.4e-29 103.7 0.8 1.8e-29 103.4 0.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Tctex-1 PF03645.8 ESA01031.1 - 1e-25 89.4 0.5 1e-25 89.4 0.4 1.4 2 0 0 2 2 2 1 Tctex-1 family DUF1968 PF09291.5 ESA01031.1 - 0.036 13.8 0.8 0.063 13.0 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1968) RNase_H PF00075.19 ESA01032.1 - 4.1e-14 53.0 0.0 6.7e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 RNase H F-box-like PF12937.2 ESA01033.1 - 0.11 12.3 0.4 0.23 11.2 0.3 1.6 1 0 0 1 1 1 0 F-box-like Pox_H7 PF04787.7 ESA01034.1 - 1.9 8.2 4.9 3.6 7.3 1.2 2.3 1 1 1 2 2 2 0 Late protein H7 HMG_box PF00505.14 ESA01036.1 - 0.0041 17.3 0.1 0.0057 16.8 0.1 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA01036.1 - 0.087 13.1 0.1 0.11 12.8 0.1 1.1 1 0 0 1 1 1 0 HMG-box domain BTB PF00651.26 ESA01037.1 - 7.4e-16 58.1 0.2 1.7e-15 56.9 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01037.1 - 2.9e-06 27.0 1.7 3.9e-05 23.4 0.3 2.6 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF1108 PF06531.6 ESA01037.1 - 0.11 12.6 2.4 0.18 12.0 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1108) RE_EcoO109I PF14511.1 ESA01039.1 - 0.073 12.4 0.7 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 Type II restriction endonuclease EcoO109I 7tm_6 PF02949.15 ESA01041.1 - 0.057 12.2 0.3 0.062 12.1 0.2 1.0 1 0 0 1 1 1 0 7tm Odorant receptor DUF812 PF05667.6 ESA01042.1 - 0.0049 15.4 14.8 0.0049 15.4 10.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Spc7 PF08317.6 ESA01042.1 - 0.014 14.0 30.5 0.021 13.5 12.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1409 PF07197.7 ESA01042.1 - 0.016 15.2 2.9 0.1 12.6 2.0 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) V_ATPase_I PF01496.14 ESA01042.1 - 0.04 11.7 15.9 0.053 11.3 11.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Filament PF00038.16 ESA01042.1 - 0.051 13.0 28.7 0.14 11.6 13.0 2.2 1 1 1 2 2 2 0 Intermediate filament protein MCC-bdg_PDZ PF10506.4 ESA01042.1 - 0.12 12.2 12.2 1.1 9.1 0.4 3.7 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Atg14 PF10186.4 ESA01042.1 - 0.15 10.9 30.0 0.022 13.7 11.6 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Fez1 PF06818.10 ESA01042.1 - 0.16 11.9 29.0 2.7 7.9 0.9 2.6 1 1 1 2 2 2 0 Fez1 Cortex-I_coil PF09304.5 ESA01042.1 - 0.22 11.5 28.5 0.16 12.0 4.9 3.3 2 1 1 3 3 3 0 Cortexillin I, coiled coil EzrA PF06160.7 ESA01042.1 - 0.37 8.9 25.0 0.009 14.2 8.8 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Cob_adeno_trans PF01923.13 ESA01042.1 - 0.42 10.3 13.9 0.031 14.0 2.9 2.3 1 1 0 2 2 2 0 Cobalamin adenosyltransferase OmpH PF03938.9 ESA01042.1 - 0.45 10.4 24.6 2.2 8.2 9.3 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) FAA_hydrolase_N PF09298.6 ESA01042.1 - 0.66 10.0 9.0 0.1 12.6 2.2 2.5 1 1 0 2 2 2 0 Fumarylacetoacetase N-terminal Mnd1 PF03962.10 ESA01042.1 - 0.92 9.1 27.4 0.23 11.0 9.4 2.2 1 1 1 2 2 2 0 Mnd1 family DUF848 PF05852.6 ESA01042.1 - 1.4 8.7 23.2 0.29 10.9 5.3 3.0 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1664 PF07889.7 ESA01042.1 - 1.6 8.5 18.1 0.42 10.4 4.0 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.7 ESA01042.1 - 1.6 8.5 6.9 0.42 10.4 0.8 2.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.2 ESA01042.1 - 2.4 8.0 38.0 0.83 9.4 7.9 2.4 1 1 2 3 3 3 0 Tropomyosin like NPV_P10 PF05531.7 ESA01042.1 - 2.9 8.2 8.9 9.7 6.5 0.2 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Rotamase PF00639.16 ESA01042.1 - 3.5 8.4 9.7 26 5.6 4.1 3.1 1 1 1 2 2 2 0 PPIC-type PPIASE domain TPR_MLP1_2 PF07926.7 ESA01042.1 - 4.8 6.9 32.5 22 4.7 4.0 3.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein GAS PF13851.1 ESA01042.1 - 5.1 6.2 33.9 29 3.7 2.6 2.8 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 ESA01042.1 - 5.4 6.8 35.4 5.3 6.9 15.0 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EF-hand_6 PF13405.1 ESA01043.1 - 0.0087 15.8 0.2 0.59 10.1 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain UPF0184 PF03670.8 ESA01043.1 - 0.027 14.6 0.3 0.06 13.5 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) EF-hand_7 PF13499.1 ESA01043.1 - 0.037 14.1 0.8 0.16 12.0 0.5 2.0 1 1 1 2 2 2 0 EF-hand domain pair Tn7_Tnp_TnsA_C PF08721.6 ESA01043.1 - 0.13 12.2 0.5 1 9.3 0.3 2.1 1 1 0 1 1 1 0 TnsA endonuclease C terminal EF-hand_1 PF00036.27 ESA01043.1 - 4.2 6.9 5.1 0.93 8.9 0.3 2.5 3 1 1 4 4 4 0 EF hand BCS1_N PF08740.6 ESA01044.1 - 0.0019 17.8 0.0 0.65 9.5 0.0 2.6 2 0 0 2 2 2 2 BCS1 N terminal bPH_4 PF06713.6 ESA01044.1 - 0.0037 17.1 1.8 3.1 7.7 0.0 3.3 3 0 0 3 3 3 2 Bacterial PH domain DZR PF12773.2 ESA01044.1 - 0.051 13.3 0.4 0.1 12.4 0.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon Pkinase PF00069.20 ESA01046.1 - 2.4e-36 125.2 0.3 2.7e-35 121.7 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01046.1 - 4.4e-33 114.4 0.0 1.9e-29 102.5 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESA01046.1 - 0.00096 18.2 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA01046.1 - 0.005 16.5 0.1 0.0078 15.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Monellin PF09200.5 ESA01047.1 - 0.069 12.7 0.1 7.3 6.3 0.0 2.9 2 0 0 2 2 2 0 Monellin Pkinase_Tyr PF07714.12 ESA01048.1 - 0.00027 20.1 0.0 0.00034 19.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01048.1 - 0.0016 17.6 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01049.1 - 0.00021 20.4 0.2 0.00036 19.6 0.0 1.4 1 1 1 2 2 2 1 Protein tyrosine kinase E1_DerP2_DerF2 PF02221.10 ESA01051.1 - 0.00037 20.7 0.1 0.13 12.4 0.0 2.1 1 1 1 2 2 2 2 ML domain Hemerythrin PF01814.18 ESA01052.1 - 6.6e-12 45.7 4.1 9.4e-12 45.2 2.8 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF697 PF05128.7 ESA01052.1 - 0.0099 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF697) DUF1828 PF08861.5 ESA01052.1 - 0.077 12.6 0.4 0.55 9.9 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function DUF1828 UPF0122 PF04297.9 ESA01053.1 - 0.12 12.4 0.1 0.19 11.7 0.1 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like PSRP-3_Ycf65 PF04839.8 ESA01054.1 - 0.087 12.8 4.8 6 7.0 0.0 3.3 3 0 0 3 3 3 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) bPH_4 PF06713.6 ESA01054.1 - 0.17 11.7 2.5 7.7 6.4 0.1 2.8 2 0 0 2 2 2 0 Bacterial PH domain Inhibitor_I67 PF11405.3 ESA01055.1 - 0.27 11.3 8.6 0.66 10.0 6.0 1.7 1 0 0 1 1 1 0 Bromelain inhibitor VI DUF2183 PF09949.4 ESA01057.1 - 1.1e-30 105.5 0.0 5.6e-30 103.2 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.8 ESA01057.1 - 0.00016 21.2 0.0 0.0003 20.3 0.0 1.5 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) DUF3837 PF12939.2 ESA01058.1 - 0.051 13.5 2.0 14 5.7 0.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3837) FANCI_HD1 PF14679.1 ESA01058.1 - 0.091 12.5 2.1 0.11 12.2 0.3 2.1 2 0 0 2 2 2 0 FANCI helical domain 1 DUF4259 PF14078.1 ESA01058.1 - 0.11 12.9 1.0 1.1 9.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) DUF2235 PF09994.4 ESA01059.1 - 3.1e-63 213.7 0.0 3.8e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) E1-E2_ATPase PF00122.15 ESA01061.1 - 9.2e-61 204.7 6.6 3e-60 203.1 4.6 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESA01061.1 - 6.7e-30 105.1 0.0 1.1e-29 104.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA01061.1 - 3.1e-13 50.3 0.0 1.2e-12 48.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA01061.1 - 1.1e-08 34.4 0.0 3.4e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESA01061.1 - 0.00047 19.8 0.3 0.062 12.8 0.1 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA01061.1 - 0.062 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit G10 PF01125.12 ESA01062.1 - 0.023 14.2 0.6 0.027 14.0 0.4 1.1 1 0 0 1 1 1 0 G10 protein HEM4 PF02602.10 ESA01064.1 - 0.12 11.5 0.1 0.14 11.3 0.1 1.0 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD eIF3g PF12353.3 ESA01068.1 - 0.036 13.9 2.8 0.044 13.6 1.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G UPF0506 PF11703.3 ESA01069.1 - 0.00035 20.4 9.9 0.00035 20.4 6.8 1.5 1 1 0 1 1 1 1 UPF0506 Toxin_27 PF08099.6 ESA01069.1 - 0.13 12.1 10.7 0.19 11.6 7.1 1.6 1 1 0 1 1 1 0 Scorpion calcine family Toxin_29 PF08116.6 ESA01069.1 - 0.26 11.0 12.7 0.12 12.1 7.5 1.5 1 1 0 1 1 1 0 PhTx neurotoxin family Dickkopf_N PF04706.7 ESA01069.1 - 0.36 11.0 11.0 0.63 10.2 7.6 1.5 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Conotoxin PF02950.12 ESA01069.1 - 0.39 11.5 7.8 0.49 11.2 5.4 1.3 1 0 0 1 1 1 0 Conotoxin Nodulin_late PF07127.6 ESA01069.1 - 0.44 10.6 6.7 0.61 10.2 4.6 1.2 1 0 0 1 1 1 0 Late nodulin protein Antifungal_pept PF11410.3 ESA01069.1 - 0.89 9.6 12.2 1.6 8.8 8.4 1.5 1 0 0 1 1 1 0 Antifungal peptide FAR1 PF03101.10 ESA01070.1 - 0.00063 20.2 0.4 0.00063 20.2 0.3 2.1 2 1 0 2 2 2 1 FAR1 DNA-binding domain Uma2 PF05685.7 ESA01071.1 - 4.8e-13 48.8 0.0 7.7e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-CHCC PF10276.4 ESA01071.1 - 0.005 16.6 0.2 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger domain zf-C2H2 PF00096.21 ESA01071.1 - 0.014 15.6 0.2 0.03 14.6 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type Nucleoplasmin PF03066.10 ESA01071.1 - 0.12 11.8 10.7 0.23 10.9 7.4 1.4 1 0 0 1 1 1 0 Nucleoplasmin CDC45 PF02724.9 ESA01071.1 - 0.15 10.0 4.8 0.19 9.7 3.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.5 ESA01071.1 - 0.5 10.6 12.9 1.6 8.9 9.0 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF1950 PF09187.5 ESA01072.1 - 0.073 13.2 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function(DUF1950) DUF202 PF02656.10 ESA01074.1 - 3.4e-11 43.1 0.3 1e-10 41.6 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) UL2 PF08196.6 ESA01074.1 - 0.0042 16.7 0.0 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 UL2 protein DUF2839 PF10999.3 ESA01074.1 - 0.079 13.0 0.0 0.29 11.1 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2839) Rab5ip PF07019.7 ESA01074.1 - 0.19 11.8 3.6 0.39 10.8 1.1 2.2 2 1 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Tetraspannin PF00335.15 ESA01074.1 - 3.1 7.0 8.0 1 8.6 3.4 1.8 2 1 0 2 2 2 0 Tetraspanin family Ndufs5 PF10200.4 ESA01075.1 - 2.7e-07 30.4 1.7 4e-07 29.9 1.2 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.3 ESA01075.1 - 0.011 15.8 5.4 0.021 14.9 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) CHCH PF06747.8 ESA01075.1 - 0.017 15.0 4.7 0.86 9.6 0.2 2.3 2 0 0 2 2 2 0 CHCH domain Lumazine_bd PF12870.2 ESA01075.1 - 0.028 14.4 2.5 0.031 14.3 1.8 1.1 1 0 0 1 1 1 0 Lumazine-binding domain Pet191_N PF10203.4 ESA01075.1 - 0.035 14.1 2.6 0.06 13.3 1.8 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 ESA01075.1 - 0.49 10.2 6.9 0.81 9.5 4.8 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CRC_subunit PF08624.5 ESA01075.1 - 0.52 10.2 2.5 9.3 6.1 0.3 2.0 1 1 1 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit COX6B PF02297.12 ESA01075.1 - 1.8 8.6 11.7 0.049 13.6 1.7 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb zf-rbx1 PF12678.2 ESA01077.1 - 9.5e-11 41.6 4.6 3.9e-10 39.6 3.2 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESA01077.1 - 4.5e-10 39.2 6.8 4.6e-10 39.1 0.6 2.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.20 ESA01077.1 - 1.2e-05 24.8 4.1 5.4e-05 22.7 2.8 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA01077.1 - 2.2e-05 24.3 0.7 2.2e-05 24.3 0.5 2.8 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA01077.1 - 0.00013 21.6 3.3 0.0006 19.4 2.3 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA01077.1 - 0.00026 20.6 0.6 0.0048 16.5 0.1 2.4 2 0 0 2 2 2 1 zinc-RING finger domain TRC8_N PF13705.1 ESA01077.1 - 0.00034 19.3 11.8 0.0005 18.7 8.2 1.3 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-Apc11 PF12861.2 ESA01077.1 - 0.00047 19.9 0.8 0.0026 17.5 0.2 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 ESA01077.1 - 0.00065 19.3 3.5 0.069 12.8 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA01077.1 - 0.0078 16.0 0.4 0.022 14.6 0.2 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 ESA01077.1 - 0.057 13.3 0.2 0.057 13.3 0.1 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain HAUS5 PF14817.1 ESA01078.1 - 1.7e-06 26.9 0.0 1.9e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 HAUS5 PF14817.1 ESA01079.1 - 3.6e-06 25.8 4.2 3.6e-06 25.8 2.9 2.0 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 5 DUF406 PF04175.7 ESA01079.1 - 0.045 14.2 2.9 0.062 13.7 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF406) ALMT PF11744.3 ESA01079.1 - 4.4 5.8 11.1 1.2 7.6 0.2 2.1 1 1 0 2 2 2 0 Aluminium activated malate transporter DNA_pol_delta_4 PF04081.8 ESA01080.1 - 3.9e-18 65.9 2.2 2.1e-17 63.5 1.5 2.0 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 FDF PF09532.5 ESA01080.1 - 0.096 13.2 3.2 0.18 12.3 2.2 1.5 1 0 0 1 1 1 0 FDF domain HTH_Tnp_Tc5 PF03221.11 ESA01081.1 - 1.3e-05 24.8 0.1 2.2e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_33 PF13592.1 ESA01081.1 - 0.0074 15.7 0.1 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_29 PF13551.1 ESA01081.1 - 0.049 13.7 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_19 PF12844.2 ESA01081.1 - 0.1 12.6 0.1 0.67 10.0 0.0 2.2 2 1 0 2 2 2 0 Helix-turn-helix domain adh_short PF00106.20 ESA01082.1 - 4.1e-16 59.3 0.0 6e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA01082.1 - 4.1e-06 26.5 0.0 5.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA01082.1 - 0.015 14.2 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein YqgF PF14639.1 ESA01082.1 - 0.085 12.4 0.1 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 MFS_1 PF07690.11 ESA01083.1 - 5.9e-42 143.6 27.3 8e-42 143.1 18.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA01083.1 - 1.8e-39 135.5 24.3 1.5e-29 102.8 8.3 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter ATG22 PF11700.3 ESA01083.1 - 2.1e-10 39.6 17.3 7e-05 21.4 4.4 2.2 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like MFS_2 PF13347.1 ESA01083.1 - 8.1e-09 34.3 14.8 0.00015 20.3 3.8 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 ESA01083.1 - 7.2e-07 28.9 3.5 0.0056 16.4 0.4 2.8 2 0 0 2 2 2 2 MFS_1 like family Pribosyltran PF00156.22 ESA01084.1 - 1.6e-13 50.4 0.2 2.5e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Arch_ATPase PF01637.13 ESA01085.1 - 3.7e-18 66.0 0.8 1.5e-17 64.1 0.2 2.1 2 0 0 2 2 2 1 Archaeal ATPase RNA12 PF10443.4 ESA01085.1 - 7.3e-12 44.5 0.0 1.8e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 RNA12 protein AAA_22 PF13401.1 ESA01085.1 - 2.1e-08 34.3 0.0 4.2e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA01085.1 - 3.3e-07 30.2 0.1 6.6e-06 26.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA01085.1 - 5e-05 23.3 0.0 0.00028 20.9 0.0 2.1 3 0 0 3 3 3 1 AAA ATPase domain AAA PF00004.24 ESA01085.1 - 0.00024 21.2 0.0 0.0012 19.0 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_35 PF14516.1 ESA01085.1 - 0.0017 17.0 0.2 0.0029 16.3 0.2 1.3 1 0 0 1 1 1 1 AAA-like domain Peptidase_S66 PF02016.10 ESA01085.1 - 0.0033 16.4 0.0 0.82 8.5 0.0 2.4 3 0 0 3 3 3 2 LD-carboxypeptidase Glyco_transf_17 PF04724.8 ESA01085.1 - 0.0034 16.4 0.0 1.7 7.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 17 AAA_24 PF13479.1 ESA01085.1 - 0.0076 15.8 0.0 0.6 9.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESA01085.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Borrelia_lipo_1 PF05714.6 ESA01085.1 - 0.019 14.0 3.7 0.98 8.4 0.2 2.3 2 0 0 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein AAA_29 PF13555.1 ESA01085.1 - 0.043 13.3 0.0 0.24 10.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.22 ESA01085.1 - 0.091 13.0 0.1 0.21 11.8 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.1 ESA01085.1 - 0.097 12.9 5.3 0.16 12.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain Coq4 PF05019.8 ESA01085.1 - 0.097 11.5 0.5 11 4.7 0.0 2.3 2 0 0 2 2 2 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF258 PF03193.11 ESA01085.1 - 0.16 11.1 0.0 0.55 9.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DDE_1 PF03184.14 ESA01086.1 - 4.6e-42 143.6 0.5 5.6e-42 143.3 0.3 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA01086.1 - 0.11 12.2 0.1 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease NT5C PF06941.7 ESA01088.1 - 0.057 12.9 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HTH_Tnp_Tc3_1 PF11427.3 ESA01090.1 - 0.083 12.5 0.0 0.33 10.6 0.0 2.1 1 0 0 1 1 1 0 Tc3 transposase Baculo_PEP_C PF04513.7 ESA01091.1 - 0.0019 18.0 5.8 0.0019 18.0 4.0 1.6 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Fusion_gly PF00523.13 ESA01091.1 - 0.023 12.7 0.4 0.026 12.5 0.3 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 DUF4403 PF14356.1 ESA01091.1 - 0.055 11.7 2.5 3 6.0 0.0 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4403) Sel1 PF08238.7 ESA01093.1 - 5e-39 131.8 3.8 1.5e-09 38.2 1.1 5.6 5 0 0 5 5 5 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA01093.1 - 2.3e-32 112.1 0.1 3.4e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01093.1 - 5.3e-26 91.3 0.3 1e-25 90.3 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA01093.1 - 0.0018 17.3 0.0 0.0027 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA01093.1 - 0.015 14.3 0.1 0.026 13.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA01093.1 - 0.019 14.3 0.1 0.035 13.4 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA01093.1 - 0.028 13.7 0.1 0.028 13.7 0.1 2.2 3 0 0 3 3 3 0 RIO1 family APH PF01636.18 ESA01093.1 - 0.15 11.7 0.2 0.24 11.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MIT PF04212.13 ESA01093.1 - 0.17 11.7 6.8 1 9.2 0.5 3.3 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA01093.1 - 0.33 11.4 1.7 22 5.7 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Peroxidase_2 PF01328.12 ESA01094.1 - 5.1e-23 81.2 0.0 8.7e-23 80.4 0.0 1.3 1 1 0 1 1 1 1 Peroxidase, family 2 Peptidase_S8 PF00082.17 ESA01095.1 - 9.7e-51 172.5 1.5 1.6e-50 171.8 1.0 1.4 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 ESA01095.1 - 9e-11 42.1 0.3 4.4e-10 39.9 0.2 2.3 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) PA PF02225.17 ESA01095.1 - 1.9e-10 40.3 0.1 4.6e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 PA domain Inhibitor_I9 PF05922.11 ESA01095.1 - 8e-05 23.1 0.4 0.0002 21.8 0.3 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 TFIIA PF03153.8 ESA01095.1 - 0.23 11.3 23.3 0.5 10.2 16.1 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MIP-T3 PF10243.4 ESA01095.1 - 7.9 4.8 40.1 12 4.2 27.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 WD40 PF00400.27 ESA01096.1 - 2.2e-16 59.0 0.3 1.7e-05 24.5 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat F-box PF00646.28 ESA01096.1 - 4.2e-07 29.4 0.1 9.4e-07 28.3 0.0 1.7 1 1 0 1 1 1 1 F-box domain MalF_P2 PF14785.1 ESA01096.1 - 0.021 14.7 0.2 0.057 13.2 0.1 1.7 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain F-box-like PF12937.2 ESA01096.1 - 0.14 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 F-box-like Peptidase_M28 PF04389.12 ESA01097.1 - 1.6e-30 106.1 0.0 4.6e-30 104.6 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M28 BUD22 PF09073.5 ESA01099.1 - 0.021 13.8 8.4 0.032 13.3 5.8 1.2 1 0 0 1 1 1 0 BUD22 DUF2704 PF10866.3 ESA01101.1 - 0.0014 18.0 1.0 0.0036 16.7 0.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2704) Proteasome PF00227.21 ESA01103.1 - 3.3e-34 117.8 0.0 3.9e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF1761 PF08570.5 ESA01104.1 - 1.3e-05 25.2 3.4 2.1e-05 24.4 2.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1761) DUF3147 PF11345.3 ESA01104.1 - 0.0011 19.0 3.2 0.003 17.5 2.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3147) MMR_HSR1 PF01926.18 ESA01105.1 - 6.4e-15 55.1 0.1 2.6e-14 53.1 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA01105.1 - 4e-08 32.6 0.6 5.7e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B IIGP PF05049.8 ESA01105.1 - 3.3e-06 26.1 0.0 4.9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.18 ESA01105.1 - 8.8e-05 22.3 0.3 0.52 10.1 0.1 2.6 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.11 ESA01105.1 - 0.00071 18.7 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA01105.1 - 0.0038 16.3 0.5 0.011 14.8 0.0 1.9 2 0 0 2 2 2 1 AIG1 family GTP_EFTU PF00009.22 ESA01105.1 - 0.015 14.7 0.1 4.2 6.7 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MobB PF03205.9 ESA01105.1 - 0.022 14.4 0.2 0.043 13.5 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ras PF00071.17 ESA01105.1 - 0.081 12.3 1.4 3.9 6.8 0.1 2.4 2 0 0 2 2 2 0 Ras family Miro PF08477.8 ESA01105.1 - 0.13 12.7 0.2 0.28 11.6 0.1 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_18 PF13238.1 ESA01105.1 - 0.76 10.0 4.0 6.9 6.9 0.1 2.7 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.1 ESA01105.1 - 4.3 7.2 5.4 33 4.3 0.3 2.9 3 0 0 3 3 3 0 AAA domain Pex19 PF04614.7 ESA01106.1 - 4.9e-50 170.4 21.0 4.9e-50 170.4 14.6 1.5 2 0 0 2 2 2 1 Pex19 protein family COG2 PF06148.6 ESA01106.1 - 0.032 14.0 0.6 0.12 12.2 0.2 2.2 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TINF2_N PF14973.1 ESA01106.1 - 0.15 12.1 0.9 1 9.4 0.4 2.3 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Histone_HNS PF00816.16 ESA01106.1 - 0.31 11.5 1.4 1.3 9.6 0.3 2.5 1 1 1 2 2 2 0 H-NS histone family TruB_N PF01509.13 ESA01107.1 - 1.3e-48 164.9 0.0 1.6e-48 164.6 0.0 1.0 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) Tim17 PF02466.14 ESA01108.1 - 2.5e-24 85.7 6.0 3.1e-24 85.4 4.2 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family HSA PF07529.8 ESA01109.1 - 1.5e-17 63.1 0.5 1.5e-17 63.1 0.4 1.9 2 0 0 2 2 2 1 HSA V_ATPase_I PF01496.14 ESA01109.1 - 1.1 7.0 4.7 1.9 6.2 3.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase_Tyr PF07714.12 ESA01110.1 - 0.00075 18.6 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01110.1 - 0.013 14.6 0.5 0.048 12.8 0.1 2.0 1 1 1 2 2 2 0 Protein kinase domain DUF2039 PF10217.4 ESA01110.1 - 0.22 11.5 4.2 1.5 8.8 1.3 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Bromodomain PF00439.20 ESA01111.1 - 1.7e-10 40.6 0.0 1.8e-10 40.5 0.0 1.0 1 0 0 1 1 1 1 Bromodomain CRAM_rpt PF07016.6 ESA01113.1 - 5.3 6.4 10.1 15 5.0 1.3 3.2 2 0 0 2 2 2 0 Cysteine-rich acidic integral membrane protein precursor HSP70 PF00012.15 ESA01114.1 - 5.2e-266 883.3 17.0 6e-266 883.1 11.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA01114.1 - 7e-14 51.1 2.5 7e-14 51.1 1.7 2.6 3 0 0 3 3 3 1 MreB/Mbl protein FGGY_C PF02782.11 ESA01114.1 - 0.0008 19.0 0.0 0.0022 17.6 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 ESA01114.1 - 0.0052 16.6 13.4 0.24 11.2 1.4 4.4 3 2 0 3 3 3 2 Cell division protein FtsA Phage_lysozyme PF00959.14 ESA01114.1 - 0.14 12.5 0.7 3.4 8.0 0.1 2.4 2 0 0 2 2 2 0 Phage lysozyme Hydantoinase_A PF01968.13 ESA01114.1 - 0.18 10.8 4.4 0.44 9.5 0.1 2.9 2 1 0 3 3 3 0 Hydantoinase/oxoprolinase Peptidase_C6 PF00851.13 ESA01114.1 - 0.93 8.0 6.8 1.4 7.4 4.7 1.2 1 0 0 1 1 1 0 Helper component proteinase DUF972 PF06156.8 ESA01114.1 - 2.7 8.3 9.5 4.2 7.7 5.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF972) tRNA_int_end_N2 PF12928.2 ESA01115.1 - 9.8e-15 53.7 0.0 1.7e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Pkinase_Tyr PF07714.12 ESA01117.1 - 0.0013 17.9 0.1 0.0017 17.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01117.1 - 0.083 12.0 0.1 0.16 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain Ribosomal_L32e PF01655.13 ESA01118.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L32 Pkinase PF00069.20 ESA01119.1 - 3.9e-28 98.3 0.1 1e-27 96.9 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01119.1 - 2.2e-27 95.7 0.0 3.4e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-TAZ PF02135.11 ESA01119.1 - 0.041 13.9 13.0 0.11 12.5 9.0 1.6 1 0 0 1 1 1 0 TAZ zinc finger Pkinase_Tyr PF07714.12 ESA01120.1 - 2.7e-15 56.1 0.0 4.1e-15 55.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01120.1 - 9.2e-15 54.4 0.0 1.3e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PI31_Prot_N PF11566.3 ESA01121.1 - 0.0049 16.4 1.2 0.0073 15.9 0.8 1.4 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal DDE_1 PF03184.14 ESA01123.1 - 1.9e-07 30.4 0.7 1.9e-07 30.4 0.5 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease Dimer_Tnp_hAT PF05699.9 ESA01125.1 - 9.2e-07 28.4 0.0 3.2e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA01125.1 - 5.3e-05 23.1 0.1 0.00018 21.4 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Ferritin-like PF12902.2 ESA01125.1 - 0.0088 15.6 0.7 0.025 14.1 0.3 1.7 2 0 0 2 2 2 1 Ferritin-like AMP-binding PF00501.23 ESA01126.1 - 6.2e-45 153.3 0.0 8.5e-45 152.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FAD_binding_3 PF01494.14 ESA01127.1 - 5.6e-13 48.6 0.0 6.8e-09 35.2 0.0 2.7 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ESA01127.1 - 0.0059 16.5 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA01127.1 - 0.008 15.9 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 ESA01127.1 - 0.035 13.9 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESA01127.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESA01127.1 - 0.14 11.0 0.0 0.57 9.0 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein DUF2424 PF10340.4 ESA01128.1 - 0.042 12.4 0.2 0.043 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) AAA_17 PF13207.1 ESA01129.1 - 1.9e-06 28.6 0.8 7.8e-06 26.7 0.6 2.1 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA01129.1 - 0.0002 21.2 0.2 0.00059 19.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 ESA01129.1 - 0.00029 20.3 0.0 0.00046 19.6 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain PRK PF00485.13 ESA01129.1 - 0.0012 18.4 0.0 0.046 13.2 0.0 2.2 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 ESA01129.1 - 0.0013 19.0 2.3 0.0016 18.7 0.3 2.2 2 1 0 2 2 2 1 AAA domain KAP_NTPase PF07693.9 ESA01129.1 - 0.0033 16.4 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain NB-ARC PF00931.17 ESA01129.1 - 0.0087 14.9 0.0 0.021 13.7 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.1 ESA01129.1 - 0.0087 16.0 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain CoaE PF01121.15 ESA01129.1 - 0.0094 15.3 0.0 0.32 10.3 0.0 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA PF00004.24 ESA01129.1 - 0.013 15.7 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF3589 PF12141.3 ESA01129.1 - 0.013 13.7 1.6 0.049 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3589) Thymidylate_kin PF02223.12 ESA01129.1 - 0.017 14.5 0.2 0.075 12.3 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase 6PF2K PF01591.13 ESA01129.1 - 0.029 13.4 0.0 0.058 12.4 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Torsin PF06309.6 ESA01129.1 - 0.035 13.9 0.1 0.28 11.0 0.0 2.3 2 1 0 3 3 3 0 Torsin RNA_helicase PF00910.17 ESA01129.1 - 0.046 13.8 0.0 0.098 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase APS_kinase PF01583.15 ESA01129.1 - 0.053 13.1 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase KTI12 PF08433.5 ESA01129.1 - 0.054 12.7 0.2 0.097 11.8 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 ESA01129.1 - 0.061 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin UPF0079 PF02367.12 ESA01129.1 - 0.085 12.4 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 ArgK PF03308.11 ESA01129.1 - 0.096 11.4 0.0 0.29 9.8 0.0 1.7 2 0 0 2 2 2 0 ArgK protein AAA_33 PF13671.1 ESA01129.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 ESA01129.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MobB PF03205.9 ESA01129.1 - 0.12 12.1 0.1 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 ESA01129.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.1 ESA01129.1 - 7.6 6.7 8.9 1.4 9.1 1.0 2.4 2 1 0 2 2 2 0 AAA domain BTB PF00651.26 ESA01130.1 - 3e-16 59.3 0.0 7e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA01130.1 - 9.9e-13 48.2 0.6 9.9e-13 48.2 0.4 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA01130.1 - 0.00019 21.2 2.1 0.034 13.9 0.3 2.8 1 1 1 2 2 2 2 BTB And C-terminal Kelch FAD_binding_3 PF01494.14 ESA01131.1 - 5.7e-13 48.6 0.0 4.3e-08 32.6 0.0 3.1 3 0 0 3 3 3 2 FAD binding domain NAD_binding_9 PF13454.1 ESA01131.1 - 7.4e-05 22.5 0.0 0.00041 20.1 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA01131.1 - 0.00016 21.6 0.0 0.0004 20.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 ESA01131.1 - 0.0013 18.8 0.0 0.0031 17.6 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.5 ESA01131.1 - 0.071 11.9 0.0 0.26 10.0 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase FAD_binding_3 PF01494.14 ESA01132.1 - 2.3e-12 46.6 0.0 2.4e-08 33.4 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.5 ESA01132.1 - 0.089 11.5 0.0 0.21 10.3 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase FAD_binding_3 PF01494.14 ESA01133.1 - 1.3e-15 57.3 0.0 8.1e-10 38.2 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 ESA01133.1 - 9.9e-05 22.2 0.0 0.00025 21.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA01133.1 - 0.00011 22.0 0.0 0.00071 19.3 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA01133.1 - 0.0053 16.8 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Delta_lysin PF05372.6 ESA01134.1 - 0.15 11.4 0.2 4.3 6.7 0.0 2.7 2 0 0 2 2 2 0 Delta lysin family TLD PF07534.11 ESA01135.1 - 8e-14 51.8 1.2 1.4e-13 50.9 0.8 1.5 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA01136.1 - 2.5e-18 66.0 0.1 4.3e-18 65.3 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA01136.1 - 1.1e-14 54.6 3.3 4.5e-14 52.6 0.7 2.5 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA01136.1 - 0.023 14.5 3.6 0.5 10.2 0.3 3.3 1 1 1 3 3 3 0 BTB And C-terminal Kelch BTB PF00651.26 ESA01137.1 - 5.7e-08 32.7 0.0 6.2e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain GalP_UDP_tr_C PF02744.12 ESA01137.1 - 0.071 12.6 0.0 0.084 12.4 0.0 1.0 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain SAM_1 PF00536.25 ESA01138.1 - 5.7e-08 32.8 0.2 4.2e-07 30.0 0.0 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 ESA01138.1 - 6.5e-06 25.8 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.12 ESA01138.1 - 0.00035 20.3 0.0 0.00075 19.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) APP_amyloid PF10515.4 ESA01138.1 - 0.095 12.9 0.5 0.27 11.5 0.4 1.7 1 0 0 1 1 1 0 beta-amyloid precursor protein C-terminus TLD PF07534.11 ESA01139.1 - 1.9e-11 44.1 0.4 7.2e-11 42.2 0.1 2.1 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA01139.1 - 8.8e-11 41.7 0.1 2.1e-10 40.5 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01139.1 - 5.4e-07 29.4 0.9 0.00026 20.7 0.1 2.8 2 1 1 3 3 3 2 BTB And C-terminal Kelch tRNA-synt_1g PF09334.6 ESA01140.1 - 0.035 12.7 0.0 0.037 12.7 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (M) Helitron_like_N PF14214.1 ESA01141.1 - 9.5e-23 80.8 0.3 1e-22 80.7 0.2 1.0 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus A2L_zn_ribbon PF08792.5 ESA01142.1 - 0.081 12.4 5.5 0.2 11.1 3.8 1.7 1 0 0 1 1 1 0 A2L zinc ribbon domain Stc1 PF12898.2 ESA01142.1 - 0.13 12.3 2.1 0.27 11.3 1.5 1.6 1 1 0 1 1 1 0 Stc1 domain Drf_FH1 PF06346.7 ESA01144.1 - 0.0052 16.2 21.9 0.007 15.8 15.2 1.1 1 0 0 1 1 1 1 Formin Homology Region 1 PIH1 PF08190.7 ESA01144.1 - 0.014 14.8 0.6 0.019 14.3 0.4 1.2 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 PAT1 PF09770.4 ESA01144.1 - 3.3 5.8 9.7 3.8 5.6 6.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pro-rich PF15240.1 ESA01144.1 - 4.1 7.4 29.0 5.8 6.9 20.1 1.1 1 0 0 1 1 1 0 Proline-rich HD_3 PF13023.1 ESA01146.1 - 5e-47 159.6 1.1 5.8e-47 159.5 0.8 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 ESA01146.1 - 5.9e-07 29.5 0.2 1e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 HD domain DUF3357 PF11837.3 ESA01147.1 - 0.14 11.9 0.2 0.19 11.5 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) DinB PF05163.7 ESA01148.1 - 0.16 11.6 0.1 0.33 10.6 0.1 1.5 1 0 0 1 1 1 0 DinB family DUF427 PF04248.7 ESA01149.1 - 5.2e-29 99.7 0.4 6e-29 99.5 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) Stc1 PF12898.2 ESA01150.1 - 7.4e-20 70.8 14.7 1e-19 70.3 10.2 1.2 1 0 0 1 1 1 1 Stc1 domain zf-RING_5 PF14634.1 ESA01150.1 - 0.013 15.2 3.5 0.013 15.2 2.4 2.8 3 0 0 3 3 3 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA01150.1 - 0.77 9.4 13.7 0.1 12.3 3.5 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Cu2_monooxygen PF01082.15 ESA01150.1 - 1.1 9.2 7.4 1.5 8.7 5.1 1.3 1 1 0 1 1 1 0 Copper type II ascorbate-dependent monooxygenase, N-terminal domain zf-CHY PF05495.7 ESA01150.1 - 3.2 7.9 16.2 17 5.6 0.2 3.0 1 1 1 2 2 2 0 CHY zinc finger zf-C2H2_2 PF12756.2 ESA01150.1 - 8 6.6 12.2 44 4.2 0.1 2.5 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PMT PF02366.13 ESA01151.1 - 7.8e-82 274.3 18.3 7.8e-82 274.3 12.7 2.4 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 ESA01151.1 - 7e-17 61.5 4.6 3.9e-16 59.1 2.2 2.2 1 1 1 2 2 2 2 MIR domain WD40 PF00400.27 ESA01152.1 - 5.9e-57 187.6 17.8 6.4e-12 44.8 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.6 ESA01152.1 - 5.6e-12 44.7 3.1 1.1e-11 43.7 2.2 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nup160 PF11715.3 ESA01152.1 - 0.0038 15.4 0.2 0.034 12.3 0.0 2.3 2 1 0 2 2 2 1 Nucleoporin Nup120/160 Nbas_N PF15492.1 ESA01152.1 - 0.024 13.7 0.0 0.12 11.4 0.0 2.1 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal SF3b10 PF07189.6 ESA01153.1 - 3.1e-38 129.4 0.0 3.6e-38 129.2 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) DUF2264 PF10022.4 ESA01153.1 - 0.081 11.5 0.2 0.088 11.4 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) E1-E2_ATPase PF00122.15 ESA01154.1 - 3.1e-52 176.9 0.8 3.1e-52 176.9 0.6 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESA01154.1 - 4e-47 161.3 0.3 7e-47 160.6 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 ESA01154.1 - 5.4e-16 58.4 2.0 5.4e-07 29.6 0.3 2.9 3 0 0 3 3 3 2 Heavy-metal-associated domain HAD PF12710.2 ESA01154.1 - 1.7e-15 57.6 0.0 3.7e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA01154.1 - 0.00089 18.9 1.6 0.0041 16.7 0.6 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Dynein_heavy PF03028.10 ESA01155.1 - 4.1e-196 653.1 0.1 4.1e-196 653.1 0.1 2.8 3 0 0 3 3 3 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 ESA01155.1 - 1.4e-186 621.3 26.0 1.4e-186 621.3 18.0 4.9 6 1 0 6 6 6 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 ESA01155.1 - 3.5e-135 450.6 11.4 3.5e-135 450.6 7.9 7.5 7 2 0 8 8 7 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 ESA01155.1 - 3.2e-80 268.9 0.0 1.7e-79 266.5 0.0 2.1 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 ESA01155.1 - 1.4e-46 158.6 0.3 2.2e-45 154.7 0.1 2.7 2 1 0 2 2 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 ESA01155.1 - 3.1e-45 153.7 0.0 4.7e-44 149.9 0.0 2.9 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 ESA01155.1 - 1.2e-43 149.2 8.3 1.2e-43 149.2 5.7 2.7 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 ESA01155.1 - 2.1e-29 102.0 0.0 9.7e-13 48.0 0.0 6.1 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_7 PF12775.2 ESA01155.1 - 5.5e-20 71.5 0.0 2.1e-19 69.6 0.0 2.0 2 0 0 2 2 1 1 P-loop containing dynein motor region D3 AAA PF00004.24 ESA01155.1 - 5.2e-13 49.3 0.0 0.0035 17.5 0.0 5.4 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA01155.1 - 1.8e-12 47.5 0.0 0.033 14.3 0.0 5.7 5 0 0 5 5 5 3 AAA domain AAA_33 PF13671.1 ESA01155.1 - 9.9e-11 41.6 0.0 0.054 13.3 0.0 5.0 4 0 0 4 4 4 3 AAA domain AAA_17 PF13207.1 ESA01155.1 - 1.5e-08 35.5 0.3 0.074 13.8 0.0 6.1 5 0 0 5 5 4 2 AAA domain AAA_18 PF13238.1 ESA01155.1 - 7e-08 32.8 5.1 0.027 14.7 0.0 6.1 6 0 0 6 6 4 2 AAA domain AAA_16 PF13191.1 ESA01155.1 - 2.1e-07 31.0 0.1 0.24 11.3 0.1 5.2 4 1 0 4 4 4 2 AAA ATPase domain AAA_19 PF13245.1 ESA01155.1 - 2.9e-07 30.1 0.1 1.2 8.8 0.0 4.5 4 0 0 4 4 4 2 Part of AAA domain T2SE PF00437.15 ESA01155.1 - 1.2e-06 27.6 0.0 0.17 10.7 0.0 3.8 3 0 0 3 3 3 2 Type II/IV secretion system protein Mg_chelatase PF01078.16 ESA01155.1 - 9e-06 24.9 1.0 0.68 9.0 0.0 3.6 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.13 ESA01155.1 - 8.9e-05 22.0 0.0 5.8 6.3 0.0 4.4 4 0 0 4 4 4 1 FtsK/SpoIIIE family AAA_29 PF13555.1 ESA01155.1 - 0.00021 20.7 0.0 0.69 9.4 0.0 3.5 3 0 0 3 3 3 1 P-loop containing region of AAA domain IstB_IS21 PF01695.12 ESA01155.1 - 0.00092 18.6 0.1 0.51 9.7 0.0 3.8 3 0 0 3 3 3 1 IstB-like ATP binding protein ABC_tran PF00005.22 ESA01155.1 - 0.0039 17.4 5.4 13 6.1 0.0 5.5 6 0 0 6 6 4 0 ABC transporter AAA_25 PF13481.1 ESA01155.1 - 0.018 14.4 0.0 0.68 9.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain HopW1-1 PF15457.1 ESA01155.1 - 0.069 12.1 2.2 3.7 6.5 0.0 2.8 2 0 0 2 2 2 0 Type III T3SS secreted effector HopW1-1/HopPmaA Snf7 PF03357.16 ESA01156.1 - 1.6e-22 79.6 18.9 1.6e-22 79.6 13.1 1.4 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.9 ESA01156.1 - 0.0017 17.8 5.1 0.0027 17.1 3.5 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway GrpE PF01025.14 ESA01156.1 - 0.016 14.7 6.4 0.029 13.9 4.4 1.5 1 0 0 1 1 1 0 GrpE DASH_Dad1 PF08649.5 ESA01156.1 - 0.078 12.6 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad1 DUF3385 PF11865.3 ESA01156.1 - 0.23 11.3 2.1 0.32 10.9 1.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) YlqD PF11068.3 ESA01156.1 - 2.3 8.2 15.6 3.8 7.5 5.2 2.6 1 1 1 2 2 2 0 YlqD protein tRNA_int_endo PF01974.12 ESA01157.1 - 5.5e-20 70.9 0.0 1e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain LMBR1 PF04791.11 ESA01157.1 - 0.0041 15.7 1.3 0.0044 15.6 0.9 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein ATG2_CAD PF13329.1 ESA01157.1 - 0.03 13.9 7.2 1 8.9 1.9 2.2 1 1 1 2 2 2 0 Autophagy-related protein 2 CAD motif DUF342 PF03961.8 ESA01157.1 - 1.1 7.6 12.0 1.3 7.3 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3404 PF11884.3 ESA01158.1 - 0.31 9.8 2.9 0.16 10.8 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3404) Fork_head PF00250.13 ESA01161.1 - 5.7e-34 116.0 0.3 6.1e-34 115.9 0.2 1.0 1 0 0 1 1 1 1 Fork head domain VPS9 PF02204.13 ESA01162.1 - 1.6e-25 89.1 0.0 1.6e-24 85.9 0.0 2.5 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain OSCP PF00213.13 ESA01162.1 - 0.0015 18.4 0.6 0.056 13.2 0.1 2.7 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit Pkinase_Tyr PF07714.12 ESA01164.1 - 1e-05 24.7 0.0 1.3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01164.1 - 0.00065 18.9 0.0 0.0011 18.2 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain UPF0236 PF06782.6 ESA01164.1 - 0.02 13.3 0.0 0.023 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) DUF1014 PF06244.7 ESA01164.1 - 0.11 12.6 0.6 0.28 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1014) Filo_VP35 PF02097.10 ESA01165.1 - 0.087 12.0 0.7 0.12 11.5 0.5 1.2 1 0 0 1 1 1 0 Filoviridae VP35 BTB PF00651.26 ESA01166.1 - 1e-14 54.4 0.3 1.7e-13 50.5 0.0 2.9 1 1 1 2 2 2 1 BTB/POZ domain HATPase_c_3 PF13589.1 ESA01166.1 - 0.00097 18.8 0.0 0.0029 17.2 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf-RVT PF13966.1 ESA01168.1 - 9.1e-05 22.7 2.0 0.011 16.0 0.0 2.9 2 0 0 2 2 2 2 zinc-binding in reverse transcriptase RNase_H PF00075.19 ESA01168.1 - 0.024 14.9 0.0 0.047 14.0 0.0 1.4 1 0 0 1 1 1 0 RNase H DUF2719 PF10891.3 ESA01169.1 - 0.48 10.1 2.5 4.8 6.9 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2719) TLD PF07534.11 ESA01170.1 - 2e-18 66.7 1.9 3e-18 66.1 0.6 1.9 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA01170.1 - 4e-18 65.4 0.5 1.3e-17 63.8 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA01170.1 - 0.00011 21.9 2.3 0.00014 21.6 0.4 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA01171.1 - 1.8e-18 66.5 0.4 3.6e-18 65.5 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01171.1 - 0.02 14.7 2.0 0.12 12.1 0.1 2.9 2 2 2 4 4 4 0 BTB And C-terminal Kelch Uma2 PF05685.7 ESA01173.1 - 6.2e-15 54.9 0.0 8.1e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease zf-Di19 PF05605.7 ESA01173.1 - 0.0098 15.9 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 ESA01173.1 - 0.041 14.0 0.1 0.088 12.9 0.1 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESA01173.1 - 0.053 13.8 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA01173.1 - 0.072 13.4 0.4 0.3 11.5 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type Pkinase PF00069.20 ESA01174.1 - 3e-25 88.8 0.0 2.4e-18 66.2 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01174.1 - 3.7e-23 81.9 0.0 4.4e-13 48.9 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA01174.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family HLH PF00010.21 ESA01176.1 - 7.7e-17 60.7 0.4 1e-16 60.3 0.3 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Vasculin PF15337.1 ESA01176.1 - 0.0086 16.5 0.1 0.01 16.2 0.1 1.2 1 0 0 1 1 1 1 Vascular protein family Vasculin-like 1 Sec34 PF04136.10 ESA01176.1 - 0.071 12.8 0.3 0.073 12.7 0.2 1.0 1 0 0 1 1 1 0 Sec34-like family DUF2972 PF11186.3 ESA01176.1 - 0.072 12.9 0.9 0.074 12.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) DNA_topoisoIV PF00521.15 ESA01177.1 - 0.86 8.3 7.4 2.6 6.8 5.1 1.8 1 1 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A RINGv PF12906.2 ESA01180.1 - 1.6e-12 47.2 6.7 4.1e-12 45.9 4.7 1.8 1 0 0 1 1 1 1 RING-variant domain SUR7 PF06687.7 ESA01180.1 - 0.0051 16.3 0.3 0.0051 16.3 0.2 2.1 1 1 1 2 2 2 1 SUR7/PalI family RecR PF02132.10 ESA01180.1 - 0.03 13.7 0.3 0.03 13.7 0.2 2.0 2 0 0 2 2 2 0 RecR protein DUF3592 PF12158.3 ESA01180.1 - 0.086 12.6 0.5 1.6 8.5 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3592) Adipogenin PF15202.1 ESA01180.1 - 0.84 9.5 0.0 0.84 9.5 0.0 3.4 3 1 1 4 4 4 0 Adipogenin OAD_gamma PF04277.8 ESA01180.1 - 2.5 8.5 0.0 2.5 8.5 0.0 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain BTB PF00651.26 ESA01181.1 - 1.1e-07 31.8 0.2 2.2e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA01183.1 - 1.1e-07 31.7 1.2 1.4e-06 28.2 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain Pkinase_Tyr PF07714.12 ESA01184.1 - 1e-40 139.4 0.0 1.2e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01184.1 - 1.4e-37 129.3 0.0 1.6e-37 129.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA01184.1 - 0.00056 19.0 0.2 0.00075 18.6 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA01184.1 - 0.019 14.7 0.1 0.027 14.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA01184.1 - 0.059 12.6 0.0 0.091 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.12 ESA01185.1 - 7.1e-08 31.8 0.0 1e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01185.1 - 0.035 13.2 0.0 0.049 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain FLYWCH PF04500.11 ESA01186.1 - 6.7e-13 48.3 2.3 1.5e-12 47.2 1.6 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 ESA01186.1 - 9.2e-09 35.3 0.0 1.4e-07 31.5 0.0 2.7 3 0 0 3 3 3 1 MULE transposase domain RNA_pol_Rpb4 PF03874.11 ESA01186.1 - 0.024 14.6 0.3 0.12 12.4 0.0 2.2 2 1 1 3 3 3 0 RNA polymerase Rpb4 DNA_primase_lrg PF04104.9 ESA01188.1 - 2.9e-73 246.3 2.5 2.9e-73 246.3 1.8 1.7 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit Nitroreductase PF00881.19 ESA01188.1 - 0.14 11.9 0.1 9.6 6.0 0.0 2.5 2 1 0 2 2 2 0 Nitroreductase family Herpes_ori_bp PF02399.10 ESA01190.1 - 1.1e-19 69.9 2.7 2.5e-09 35.7 0.0 2.5 2 1 0 3 3 3 2 Origin of replication binding protein Enterotoxin_HS1 PF08090.6 ESA01192.1 - 0.061 13.0 0.6 0.16 11.7 0.4 1.6 1 0 0 1 1 1 0 Heat stable E.coli enterotoxin 1 DUF3592 PF12158.3 ESA01193.1 - 9.8e-06 25.4 0.1 9.8e-06 25.4 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3592) DUF3139 PF11337.3 ESA01193.1 - 0.12 12.6 0.2 0.12 12.6 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) ST7 PF04184.7 ESA01193.1 - 0.18 9.9 1.0 0.26 9.4 0.7 1.1 1 0 0 1 1 1 0 ST7 protein Metallophos PF00149.23 ESA01194.1 - 2e-10 40.3 0.3 4.3e-10 39.3 0.2 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA01194.1 - 4e-05 23.5 0.1 5.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain zf-CCCH PF00642.19 ESA01195.1 - 1.5e-07 30.9 35.4 0.0071 16.0 0.5 5.9 4 3 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DHOase PF12890.2 ESA01195.1 - 2.2 7.9 3.9 16 5.1 0.2 2.3 1 1 0 2 2 2 0 Dihydro-orotase-like Lum_binding PF00677.12 ESA01196.1 - 3e-42 142.4 0.1 2.8e-21 75.1 0.1 2.2 2 0 0 2 2 2 2 Lumazine binding domain EMP24_GP25L PF01105.19 ESA01197.1 - 3.5e-53 180.0 1.1 4.4e-53 179.7 0.8 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ribosomal_L13 PF00572.13 ESA01198.1 - 1.8e-25 89.4 1.8 2e-25 89.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L13 Aminotran_1_2 PF00155.16 ESA01199.1 - 2.5e-17 62.8 0.0 1.1e-14 54.1 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II zf-RING_2 PF13639.1 ESA01200.1 - 9.6e-07 28.5 2.9 2.4e-06 27.2 2.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA01200.1 - 0.0013 18.7 0.6 0.0033 17.5 0.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA01200.1 - 0.0035 17.3 4.4 0.0071 16.3 3.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA01200.1 - 0.0048 16.5 2.9 0.014 15.0 2.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 ESA01200.1 - 0.11 12.4 0.5 0.27 11.2 0.3 1.6 1 0 0 1 1 1 0 RING-like domain zf-RING_5 PF14634.1 ESA01200.1 - 0.14 11.8 3.2 0.3 10.8 2.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.1 ESA01200.1 - 0.15 11.6 3.0 0.25 10.9 2.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.24 ESA01200.1 - 0.37 10.5 2.8 0.83 9.3 2.0 1.6 1 0 0 1 1 1 0 PHD-finger SPRY PF00622.23 ESA01202.1 - 8.4e-11 42.0 0.4 1.5e-10 41.1 0.1 1.6 2 0 0 2 2 2 1 SPRY domain BTB PF00651.26 ESA01202.1 - 1.2e-06 28.4 1.4 2.9e-06 27.2 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain L31 PF09784.4 ESA01205.1 - 2.9e-37 126.8 0.3 3.2e-37 126.7 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 DUF4591 PF15261.1 ESA01205.1 - 0.1 12.8 0.3 0.13 12.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) Glyco_transf_20 PF00982.16 ESA01206.1 - 7.5e-173 575.3 0.1 1.1e-172 574.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 ESA01206.1 - 7.2e-65 218.1 0.0 1.2e-64 217.4 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.7 ESA01206.1 - 2.4e-08 33.8 0.1 0.00027 20.6 0.1 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Glyco_trans_1_4 PF13692.1 ESA01206.1 - 0.0036 17.4 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 RRM_1 PF00076.17 ESA01207.1 - 2.7e-22 78.1 0.1 4e-22 77.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA01207.1 - 2.4e-17 62.6 0.0 3.6e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA01207.1 - 1.9e-12 46.8 0.1 5.3e-12 45.3 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA01207.1 - 0.023 14.4 0.1 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Pkinase_Tyr PF07714.12 ESA01208.1 - 2.6e-44 151.2 0.0 4.2e-42 144.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA01208.1 - 2.4e-43 148.1 2.5 2.9e-43 147.9 0.3 2.2 2 2 0 2 2 2 1 Protein kinase domain EcoEI_R_C PF08463.5 ESA01208.1 - 0.0024 17.7 0.1 0.0047 16.7 0.1 1.5 1 0 0 1 1 1 1 EcoEI R protein C-terminal APH PF01636.18 ESA01208.1 - 0.035 13.8 0.1 0.062 13.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDE_1 PF03184.14 ESA01209.1 - 9.9e-39 132.7 0.0 1.5e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA01209.1 - 7.4e-14 51.3 1.3 2.1e-13 49.8 0.1 2.4 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA01209.1 - 9.8e-05 22.1 0.0 0.00019 21.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Tetraspannin PF00335.15 ESA01209.1 - 0.078 12.2 2.6 0.14 11.4 1.8 1.3 1 0 0 1 1 1 0 Tetraspanin family Pkinase_Tyr PF07714.12 ESA01210.1 - 1.7e-27 96.1 0.1 5.6e-27 94.4 0.0 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01210.1 - 4.1e-27 94.9 1.2 4.1e-27 94.9 0.8 2.0 2 0 0 2 2 2 1 Protein kinase domain NOB1_Zn_bind PF08772.6 ESA01210.1 - 0.0052 16.5 13.3 0.38 10.6 0.4 3.8 3 0 0 3 3 3 3 Nin one binding (NOB1) Zn-ribbon like Spt5-NGN PF03439.8 ESA01210.1 - 0.15 11.8 4.0 11 5.9 0.0 3.8 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section zf-DBF PF07535.7 ESA01210.1 - 1.8 8.3 32.9 0.67 9.6 4.1 4.5 3 3 0 3 3 3 0 DBF zinc finger CTP_transf_1 PF01148.15 ESA01211.1 - 7.3e-20 71.7 6.7 7.5e-18 65.1 1.8 2.0 1 1 1 2 2 2 2 Cytidylyltransferase family Eno-Rase_FAD_bd PF07055.7 ESA01211.1 - 0.08 12.9 0.2 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain ATP12 PF07542.6 ESA01212.1 - 2.3e-37 127.6 0.0 3.9e-37 126.9 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein DUF777 PF05606.6 ESA01212.1 - 0.064 12.4 1.0 0.12 11.6 0.1 1.9 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF777) MRP-S28 PF10213.4 ESA01213.1 - 4.5e-32 110.8 0.1 5.8e-32 110.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein WD40 PF00400.27 ESA01214.1 - 6.4e-15 54.3 4.1 4.8e-06 26.2 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat TUSC2 PF15000.1 ESA01216.1 - 0.028 14.4 0.0 0.06 13.4 0.0 1.5 1 0 0 1 1 1 0 Tumour suppressor candidate 2 F-box-like PF12937.2 ESA01219.1 - 0.00017 21.2 2.1 0.00024 20.7 1.4 1.3 1 1 0 1 1 1 1 F-box-like DUF3788 PF12663.2 ESA01222.1 - 0.084 12.5 2.2 4.1 7.0 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3788) DUF1542 PF07564.6 ESA01224.1 - 0.013 15.4 1.0 0.038 13.9 0.7 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA01224.1 - 0.033 13.9 0.8 0.1 12.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 zf-B_box PF00643.19 ESA01224.1 - 0.29 11.0 4.4 0.55 10.1 3.1 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF3336 PF11815.3 ESA01226.1 - 9.4e-30 103.0 0.4 2.3e-29 101.7 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ESA01226.1 - 1.2e-17 64.5 0.0 1.8e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase Alb1 PF09135.6 ESA01227.1 - 0.00014 22.4 14.4 0.00018 22.1 10.0 1.1 1 0 0 1 1 1 1 Alb1 Erp_C PF06780.6 ESA01227.1 - 0.078 12.8 5.2 0.084 12.7 3.6 1.1 1 0 0 1 1 1 0 Erp protein C-terminus DUF3635 PF12330.3 ESA01227.1 - 0.38 10.8 3.1 0.53 10.3 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3635) ATP-synt_ab PF00006.20 ESA01228.1 - 1.3e-114 381.0 0.0 2.5e-114 380.1 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESA01228.1 - 3.9e-24 85.2 0.9 7.9e-24 84.3 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESA01228.1 - 3.4e-14 52.8 4.5 1.2e-13 51.0 3.0 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.1 ESA01228.1 - 0.09 12.6 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain E2R135 PF11570.3 ESA01228.1 - 0.21 11.6 0.4 2.9 7.9 0.0 2.4 2 1 1 3 3 3 0 Coiled-coil receptor-binding R-domain of colicin E2 DPM3 PF08285.6 ESA01229.1 - 2.2e-31 107.5 0.1 2.4e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF1624 PF07786.7 ESA01229.1 - 0.049 12.9 0.1 0.057 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1624) Pox_A21 PF05323.7 ESA01229.1 - 1.5 9.2 5.5 3 8.2 2.4 2.0 2 0 0 2 2 2 0 Poxvirus A21 Protein BTB PF00651.26 ESA01231.1 - 2.9e-15 56.2 0.2 8.9e-15 54.6 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA01231.1 - 5.3e-15 55.6 2.2 1.2e-07 31.7 0.4 2.7 2 1 1 3 3 3 2 TLD BACK PF07707.10 ESA01231.1 - 2.2e-05 24.2 0.1 7.7e-05 22.4 0.1 2.1 1 0 0 1 1 1 1 BTB And C-terminal Kelch Sel1 PF08238.7 ESA01233.1 - 2.3e-43 145.6 16.5 1.1e-10 41.7 0.3 6.6 6 1 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA01233.1 - 0.013 15.3 11.1 3.9 7.4 0.1 4.7 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain DUF1033 PF06279.6 ESA01233.1 - 3.3 7.5 6.5 16 5.3 0.0 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF1033) Sel1 PF08238.7 ESA01234.1 - 6.2e-72 236.4 20.5 1.3e-08 35.2 0.0 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_16 PF13432.1 ESA01234.1 - 3.5e-05 24.3 0.0 1.8 9.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA01234.1 - 0.00018 21.7 5.5 4.5 7.9 0.1 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA01234.1 - 0.013 15.6 12.2 2.3 8.6 0.2 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat MMtag PF10159.4 ESA01234.1 - 0.049 13.6 14.8 1.6 8.8 0.3 5.2 1 1 5 6 6 6 0 Kinase phosphorylation protein TPR_12 PF13424.1 ESA01234.1 - 0.08 12.8 11.3 7.4 6.5 1.1 4.9 3 2 0 4 4 4 0 Tetratricopeptide repeat SLIDE PF09111.5 ESA01234.1 - 0.16 11.7 1.0 17 5.1 0.1 3.6 3 1 1 4 4 4 0 SLIDE TPR_19 PF14559.1 ESA01234.1 - 0.79 10.1 2.9 1.3 9.3 0.1 2.7 3 1 1 4 4 4 0 Tetratricopeptide repeat Trefoil PF00088.13 ESA01234.1 - 4.7 6.9 10.1 0.18 11.4 0.7 3.1 2 1 0 2 2 2 0 Trefoil (P-type) domain TPR_11 PF13414.1 ESA01234.1 - 9.3 5.9 25.7 1.5 8.5 0.3 6.6 2 2 5 7 7 7 0 TPR repeat Imm13 PF15564.1 ESA01236.1 - 0.079 12.6 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 13 Ku_PK_bind PF08785.6 ESA01237.1 - 5.8e-30 103.6 1.1 5.8e-30 103.6 0.7 1.8 2 0 0 2 2 2 1 Ku C terminal domain like Ku PF02735.11 ESA01237.1 - 8.4e-25 87.3 1.2 1.7e-24 86.3 0.8 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 ESA01237.1 - 6.5e-23 81.3 0.2 6.5e-23 81.3 0.1 1.8 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain VWA_2 PF13519.1 ESA01237.1 - 1.7e-05 25.0 0.0 3.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA01237.1 - 0.03 14.0 0.1 0.071 12.8 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain WAP PF00095.16 ESA01238.1 - 0.7 9.9 4.1 1 9.3 2.8 1.3 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' DOR PF14839.1 ESA01241.1 - 0.1 12.3 0.4 2.9 7.5 0.3 2.1 2 0 0 2 2 2 0 DOR family DUF1818 PF08848.6 ESA01241.1 - 0.13 12.3 1.0 1.3 9.1 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1818) DDE_1 PF03184.14 ESA01243.1 - 5.2e-15 55.1 0.1 5.7e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA01244.1 - 2.6e-08 33.5 0.1 2.9e-08 33.4 0.1 1.0 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Spt5_N PF11942.3 ESA01245.1 - 0.004 17.7 4.8 0.0045 17.5 3.4 1.1 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal MscS_porin PF12795.2 ESA01247.1 - 0.11 11.8 0.3 0.21 10.8 0.2 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain ECM11 PF15463.1 ESA01251.1 - 0.066 13.5 0.1 0.21 11.8 0.0 1.8 2 0 0 2 2 2 0 Extracellular mutant protein 11 UPF0020 PF01170.13 ESA01251.1 - 0.088 12.3 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 D5_N PF08706.6 ESA01251.1 - 0.11 12.6 0.3 0.64 10.0 0.2 2.1 1 1 0 1 1 1 0 D5 N terminal like DivIC PF04977.10 ESA01252.1 - 0.0002 20.7 4.7 0.013 14.9 1.7 2.7 2 0 0 2 2 2 2 Septum formation initiator IncA PF04156.9 ESA01252.1 - 0.054 13.0 0.1 0.054 13.0 0.1 2.1 2 0 0 2 2 2 0 IncA protein ADIP PF11559.3 ESA01252.1 - 1 9.2 6.8 0.31 10.9 1.8 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF904 PF06005.7 ESA01252.1 - 1.9 8.8 10.1 0.23 11.7 2.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Striatin PF08232.7 ESA01252.1 - 5.5 7.3 8.7 0.92 9.8 1.8 2.7 2 2 0 2 2 2 0 Striatin family Pkinase_Tyr PF07714.12 ESA01256.1 - 2.9e-32 111.7 0.0 4.5e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01256.1 - 5.2e-32 111.0 0.0 1.1e-31 109.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain zf-C3HC4_3 PF13920.1 ESA01257.1 - 6.6e-11 41.7 6.8 1e-10 41.0 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA01257.1 - 3e-09 36.5 7.9 4.7e-09 35.9 5.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA01257.1 - 3.6e-09 36.1 8.4 6.4e-09 35.3 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA01257.1 - 1.3e-08 34.7 10.1 1.9e-08 34.1 6.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA01257.1 - 7.2e-08 32.0 8.5 1.2e-07 31.3 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESA01257.1 - 0.0003 20.6 8.4 0.00056 19.7 5.8 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA01257.1 - 0.00034 20.2 5.1 0.00086 18.9 3.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESA01257.1 - 0.0022 17.7 2.4 0.0042 16.8 1.7 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 ESA01257.1 - 0.0053 16.8 6.3 0.013 15.6 4.4 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_4 PF14570.1 ESA01257.1 - 0.064 12.8 6.2 0.12 11.9 4.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 ESA01257.1 - 0.11 12.0 2.4 0.26 10.8 1.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 HNH_5 PF14279.1 ESA01257.1 - 0.19 11.7 3.0 0.29 11.1 2.1 1.3 1 0 0 1 1 1 0 HNH endonuclease Ribosomal_L7Ae PF01248.21 ESA01258.1 - 1.3e-24 85.5 0.0 1.7e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CDC50 PF03381.10 ESA01259.1 - 4.7e-96 321.2 0.0 5.6e-96 320.9 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SPW PF03779.9 ESA01259.1 - 0.65 9.4 2.9 0.81 9.1 0.4 2.0 2 0 0 2 2 2 0 SPW repeat DUF4282 PF14110.1 ESA01259.1 - 1.7 8.8 3.7 27 5.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) DUF3550 PF12070.3 ESA01260.1 - 2.5e-17 62.8 3.6 3.3e-17 62.4 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3550/UPF0682) Herpes_LMP2 PF07415.6 ESA01260.1 - 0.095 11.2 0.1 0.097 11.2 0.1 1.0 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Rab3-GTPase_cat PF13890.1 ESA01262.1 - 3.5e-56 189.1 1.3 6.3e-56 188.2 0.9 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit UbiA PF01040.13 ESA01263.1 - 4.5e-27 94.8 19.3 6.6e-27 94.3 13.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Laminin_B PF00052.13 ESA01263.1 - 0.015 14.9 0.2 0.035 13.7 0.0 1.7 2 0 0 2 2 2 0 Laminin B (Domain IV) Y_phosphatase PF00102.22 ESA01264.1 - 7.7e-72 241.4 0.0 9.3e-72 241.1 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESA01264.1 - 0.0069 16.6 0.0 0.016 15.4 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 ESA01264.1 - 0.09 12.3 0.2 0.3 10.6 0.0 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain C2 PF00168.25 ESA01266.1 - 2.6e-05 23.9 0.2 7.3e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 C2 domain TLD PF07534.11 ESA01269.1 - 1.4e-14 54.2 1.3 3.2e-14 53.1 0.9 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA01269.1 - 2.6e-06 27.2 0.2 7.3e-06 25.7 0.1 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch Dimer_Tnp_hAT PF05699.9 ESA01270.1 - 7.2e-12 44.7 0.0 1.1e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2464 PF10240.4 ESA01270.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2464) Pkinase_Tyr PF07714.12 ESA01276.1 - 6.2e-50 169.6 0.0 7.8e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01276.1 - 1.9e-46 158.3 1.0 2.5e-46 157.9 0.7 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA01276.1 - 2.6e-07 31.0 0.5 6.1e-07 29.8 0.3 1.7 1 0 0 1 1 1 1 Sel1 repeat Kdo PF06293.9 ESA01276.1 - 0.00057 19.0 0.2 0.0012 17.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA01276.1 - 0.0024 17.2 1.6 0.0048 16.2 0.2 2.0 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA01276.1 - 0.0095 15.2 0.1 0.016 14.5 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA01276.1 - 0.012 15.3 0.1 0.019 14.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family ASL_C PF08328.6 ESA01276.1 - 0.13 12.1 0.1 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal BTB PF00651.26 ESA01277.1 - 1.1e-20 73.6 0.1 2.7e-20 72.4 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA01277.1 - 3.3e-11 43.3 0.4 1.4e-10 41.2 0.1 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA01277.1 - 1.3e-07 31.3 5.2 9.1e-06 25.4 0.1 3.8 4 1 1 5 5 5 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA01277.1 - 0.0077 16.3 0.1 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 ESA01278.1 - 4.7e-19 68.4 0.2 6.1e-19 68.0 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Dyp_perox PF04261.7 ESA01279.1 - 0.12 11.0 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Dyp-type peroxidase family DUF4476 PF14771.1 ESA01279.1 - 0.44 10.6 3.2 1.1 9.3 1.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4476) Arg_repressor PF01316.16 ESA01279.1 - 4.3 6.9 6.0 3.1 7.3 0.3 3.0 2 1 1 3 3 3 0 Arginine repressor, DNA binding domain BTB PF00651.26 ESA01280.1 - 9.1e-21 73.9 0.0 1.1e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA01280.1 - 0.014 15.5 0.1 0.05 13.6 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain KAR9 PF08580.5 ESA01281.1 - 0.011 14.0 0.2 0.012 13.9 0.1 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Metallopep PF12044.3 ESA01281.1 - 0.076 11.4 0.0 0.094 11.1 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family GBP PF02263.14 ESA01284.1 - 7.2e-41 139.9 0.0 7.2e-41 139.9 0.0 2.6 2 2 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 ESA01284.1 - 1.8e-13 50.3 33.6 1.8e-13 50.3 23.3 2.4 1 1 1 2 2 2 1 Guanylate-binding protein, C-terminal domain Amidase PF01425.16 ESA01284.1 - 0.64 8.8 0.0 0.64 8.8 0.0 2.6 2 1 0 2 2 2 0 Amidase DASH_Dam1 PF08653.5 ESA01284.1 - 1.3 8.7 4.9 13 5.6 0.2 3.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 Hydantoinase_B PF02538.9 ESA01284.1 - 7.3 4.6 10.0 11 4.0 6.9 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase DUF659 PF04937.10 ESA01286.1 - 1e-06 28.3 0.0 1.2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) zf-BED PF02892.10 ESA01286.1 - 0.0018 18.0 1.4 0.003 17.2 1.0 1.4 1 0 0 1 1 1 1 BED zinc finger SPRY PF00622.23 ESA01289.1 - 6.9e-10 39.0 0.1 1.2e-09 38.3 0.1 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA01289.1 - 7.3e-10 38.8 1.4 1.3e-09 38.0 0.2 1.9 2 0 0 2 2 2 1 BTB/POZ domain zf-C2H2 PF00096.21 ESA01292.1 - 3.4e-06 27.0 2.7 5e-06 26.5 1.8 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA01292.1 - 1.1e-05 25.3 2.1 1.9e-05 24.6 1.5 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA01292.1 - 3.2e-05 23.9 0.3 5e-05 23.3 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA01292.1 - 0.02 15.0 0.6 0.031 14.4 0.4 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-Di19 PF05605.7 ESA01292.1 - 0.034 14.2 0.1 0.059 13.5 0.1 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 ESA01292.1 - 0.034 14.4 1.9 1.1 9.6 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-H2C2_5 PF13909.1 ESA01292.1 - 0.11 12.7 1.2 0.22 11.8 0.8 1.5 1 0 0 1 1 1 0 C2H2-type zinc-finger domain CpXC PF14353.1 ESA01292.1 - 0.2 11.6 2.6 0.29 11.0 1.8 1.5 1 1 0 1 1 1 0 CpXC protein CobT PF06213.7 ESA01292.1 - 1.5 7.8 18.3 1.8 7.6 12.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Phyto_Pns9_10 PF05878.6 ESA01292.1 - 5.7 5.8 6.6 6.7 5.6 4.5 1.0 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 FYDLN_acid PF09538.5 ESA01292.1 - 9.2 6.8 18.3 94 3.6 12.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Myb_DNA-bind_6 PF13921.1 ESA01293.1 - 5.7e-06 26.3 0.9 1.4e-05 25.0 0.4 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA01293.1 - 3.9e-05 23.6 1.3 9.3e-05 22.4 0.7 1.8 1 1 1 2 2 2 1 Myb-like DNA-binding domain Hid1 PF12722.2 ESA01293.1 - 7.2 4.1 10.1 8 3.9 7.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Kelch_4 PF13418.1 ESA01295.1 - 2.6e-15 55.9 3.3 9.7e-05 22.0 0.0 4.2 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA01295.1 - 1.4e-11 44.0 0.4 0.00033 20.6 0.1 4.1 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESA01295.1 - 2e-09 36.7 0.2 0.0095 15.6 0.0 4.1 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 ESA01295.1 - 7.1e-08 32.2 0.0 0.12 12.3 0.0 4.4 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA01295.1 - 1.3e-06 28.3 3.0 0.0071 16.4 0.1 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA01295.1 - 3.5e-05 23.2 2.2 0.18 11.3 0.1 4.5 4 1 0 4 4 4 2 Kelch motif ETRAMP PF09716.5 ESA01295.1 - 0.085 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Kelch_4 PF13418.1 ESA01296.1 - 7.2e-27 92.9 4.2 4.2e-05 23.2 0.0 6.1 4 2 1 5 5 5 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01296.1 - 1.6e-20 72.0 0.5 0.00091 18.8 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 ESA01296.1 - 2.2e-19 68.7 5.9 0.00046 20.2 0.1 5.8 4 1 1 5 5 5 5 Kelch motif Kelch_5 PF13854.1 ESA01296.1 - 1.1e-18 66.7 0.1 6.8e-07 29.0 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA01296.1 - 3.7e-15 55.6 5.0 0.0011 19.1 0.0 5.9 5 2 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA01296.1 - 3.2e-12 45.7 11.2 0.062 12.8 0.0 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA01297.1 - 4.3e-16 58.4 6.2 4.9e-05 22.9 0.0 5.3 4 1 2 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01297.1 - 5.2e-10 38.6 0.2 0.12 12.1 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 ESA01297.1 - 1e-09 38.2 0.2 0.076 13.2 0.0 4.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA01297.1 - 3.8e-09 36.3 0.7 0.18 11.8 0.0 5.5 4 2 1 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESA01297.1 - 2.5e-08 33.7 6.9 0.0063 16.6 0.1 5.0 3 1 2 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA01297.1 - 4e-05 23.0 14.8 0.031 13.8 0.0 5.0 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.1 ESA01298.1 - 4.1e-15 55.2 2.8 6e-06 25.9 0.0 4.3 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01298.1 - 3.8e-10 39.1 0.3 0.0046 16.6 0.1 3.8 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA01298.1 - 5.7e-09 35.7 1.6 0.024 14.7 0.2 4.0 3 1 1 4 4 4 2 Kelch motif Kelch_5 PF13854.1 ESA01298.1 - 4e-08 33.0 0.0 0.04 13.8 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA01298.1 - 3.2e-06 27.1 0.1 0.038 14.1 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA01298.1 - 0.0012 18.2 4.4 0.87 9.1 0.2 3.9 4 1 0 4 4 4 2 Kelch motif Glyoxal_oxid_N PF07250.6 ESA01298.1 - 0.054 12.5 0.0 0.087 11.8 0.0 1.3 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus Glyoxal_oxid_N PF07250.6 ESA01299.1 - 5.2e-46 156.6 0.0 2e-44 151.5 0.0 2.8 3 0 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ESA01299.1 - 3.4e-15 55.9 0.2 6.3e-15 55.0 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.1 ESA01299.1 - 1.7e-05 24.7 0.4 2.9 8.2 0.0 5.2 4 1 1 5 5 5 2 Kelch motif Kelch_4 PF13418.1 ESA01299.1 - 0.00069 19.3 1.9 0.5 10.1 0.0 4.6 4 1 0 4 4 4 1 Galactose oxidase, central domain zf-B_box PF00643.19 ESA01301.1 - 0.029 14.2 3.6 0.098 12.5 1.1 2.4 2 0 0 2 2 2 0 B-box zinc finger Herpes_UL25 PF01499.11 ESA01301.1 - 0.065 11.5 0.0 0.085 11.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Peptidase_M17_N PF02789.12 ESA01302.1 - 1.4e-14 53.9 0.5 1.8e-14 53.5 0.3 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Baculo_p33 PF05214.7 ESA01302.1 - 0.091 12.0 0.8 0.14 11.3 0.6 1.3 1 0 0 1 1 1 0 Baculovirus P33 BTB PF00651.26 ESA01303.1 - 2.7e-05 24.0 0.3 5.5e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01303.1 - 0.19 11.6 1.7 0.96 9.3 0.0 2.8 4 0 0 4 4 4 0 BTB And C-terminal Kelch p450 PF00067.17 ESA01304.1 - 5.6e-49 166.9 0.0 6.2e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 A_deaminase PF00962.17 ESA01306.1 - 2.2e-111 371.9 0.1 2.8e-111 371.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Prismane PF03063.15 ESA01307.1 - 0.022 13.1 0.0 0.026 12.9 0.0 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family EzrA PF06160.7 ESA01308.1 - 2.3e-07 29.3 8.3 3.1e-07 28.9 5.8 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Tropomyosin PF00261.15 ESA01308.1 - 6.4e-06 25.4 6.6 6.6e-06 25.3 4.0 1.4 1 1 0 1 1 1 1 Tropomyosin AAA_13 PF13166.1 ESA01308.1 - 4.6e-05 22.0 8.6 4.6e-05 22.0 6.0 2.0 1 1 1 2 2 2 1 AAA domain Filament PF00038.16 ESA01308.1 - 6.2e-05 22.6 5.3 9.5e-05 22.0 3.7 1.3 1 0 0 1 1 1 1 Intermediate filament protein Tropomyosin_1 PF12718.2 ESA01308.1 - 7.5e-05 22.6 8.0 0.00014 21.7 5.6 1.5 1 0 0 1 1 1 1 Tropomyosin like BLOC1_2 PF10046.4 ESA01308.1 - 7.6e-05 22.7 8.9 0.001 19.1 0.3 2.3 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 MscS_porin PF12795.2 ESA01308.1 - 0.00018 20.9 4.2 0.00018 20.9 2.9 1.4 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain ADIP PF11559.3 ESA01308.1 - 0.00038 20.3 8.6 0.00038 20.3 6.0 2.2 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.4 ESA01308.1 - 0.0013 18.6 4.4 0.0026 17.7 3.0 1.5 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 LPP PF04728.8 ESA01308.1 - 0.0016 18.1 0.2 0.067 12.9 0.0 3.1 1 1 3 4 4 4 2 Lipoprotein leucine-zipper Sec3_C PF09763.4 ESA01308.1 - 0.0017 16.6 11.6 0.0017 16.6 8.0 1.5 1 1 1 2 2 2 1 Exocyst complex component Sec3 Baculo_PEP_C PF04513.7 ESA01308.1 - 0.0019 18.0 7.9 0.0095 15.7 5.4 1.9 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 ESA01308.1 - 0.0023 17.1 2.3 0.003 16.7 1.6 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF3407 PF11887.3 ESA01308.1 - 0.0025 17.1 0.3 0.0036 16.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3407) Lebercilin PF15619.1 ESA01308.1 - 0.0057 16.1 7.7 0.017 14.5 5.3 1.8 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.7 ESA01308.1 - 0.0062 16.7 2.7 0.0062 16.7 1.9 2.4 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.7 ESA01308.1 - 0.0077 15.9 8.8 0.0093 15.7 2.2 2.3 1 1 1 2 2 2 1 Laminin Domain II DUF342 PF03961.8 ESA01308.1 - 0.008 14.6 11.9 0.01 14.3 8.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) STAT_alpha PF01017.15 ESA01308.1 - 0.0085 15.8 11.8 0.051 13.2 3.9 2.3 1 1 1 2 2 2 2 STAT protein, all-alpha domain TBPIP PF07106.8 ESA01308.1 - 0.0087 15.6 11.9 0.021 14.3 8.1 1.8 1 1 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_TATA_bd PF12325.3 ESA01308.1 - 0.0097 15.6 5.0 0.015 14.9 3.2 1.6 1 1 0 1 1 1 1 TATA element modulatory factor 1 TATA binding APG6 PF04111.7 ESA01308.1 - 0.01 14.9 11.2 0.014 14.4 7.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Z1 PF10593.4 ESA01308.1 - 0.011 14.9 7.5 0.014 14.5 5.2 1.3 1 0 0 1 1 1 0 Z1 domain Allexi_40kDa PF05549.6 ESA01308.1 - 0.017 14.4 7.3 0.023 13.9 5.1 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF4140 PF13600.1 ESA01308.1 - 0.018 15.5 1.1 0.81 10.1 0.1 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) bZIP_1 PF00170.16 ESA01308.1 - 0.02 14.8 7.3 0.074 13.0 2.0 2.5 1 1 1 2 2 2 0 bZIP transcription factor Phage_GPO PF05929.6 ESA01308.1 - 0.02 14.1 3.7 0.029 13.6 2.6 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3450 PF11932.3 ESA01308.1 - 0.022 14.0 4.2 0.029 13.6 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) YlqD PF11068.3 ESA01308.1 - 0.023 14.7 7.4 0.03 14.3 4.6 1.6 1 1 0 1 1 1 0 YlqD protein ERM PF00769.14 ESA01308.1 - 0.028 13.9 8.7 0.037 13.5 6.0 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Prefoldin PF02996.12 ESA01308.1 - 0.028 14.0 8.2 0.5 10.0 0.9 2.5 1 1 0 2 2 2 0 Prefoldin subunit zf-C4H2 PF10146.4 ESA01308.1 - 0.03 14.3 6.8 0.04 13.9 4.7 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Herpes_UL6 PF01763.11 ESA01308.1 - 0.031 12.4 11.0 0.054 11.6 7.6 1.5 1 1 0 1 1 1 0 Herpesvirus UL6 like V_ATPase_I PF01496.14 ESA01308.1 - 0.034 12.0 6.5 0.038 11.8 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.6 ESA01308.1 - 0.035 13.9 7.5 0.084 12.7 2.5 2.5 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 ESA01308.1 - 0.038 13.4 1.2 0.038 13.4 0.8 2.5 1 1 1 2 2 2 0 Septum formation initiator Cep57_MT_bd PF06657.8 ESA01308.1 - 0.041 13.8 1.9 0.2 11.5 0.8 2.6 1 1 1 2 2 1 0 Centrosome microtubule-binding domain of Cep57 TPR_MLP1_2 PF07926.7 ESA01308.1 - 0.041 13.6 10.3 0.67 9.7 7.1 2.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 ESA01308.1 - 0.051 13.3 7.1 0.069 12.9 3.2 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Nsp1_C PF05064.8 ESA01308.1 - 0.06 12.9 6.6 0.27 10.8 4.3 2.0 1 1 0 1 1 1 0 Nsp1-like C-terminal region DUF2524 PF10732.4 ESA01308.1 - 0.061 13.4 4.4 1.8 8.7 0.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2524) Matrilin_ccoil PF10393.4 ESA01308.1 - 0.073 12.4 3.5 0.18 11.1 0.6 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Fib_alpha PF08702.5 ESA01308.1 - 0.074 13.1 14.7 0.07 13.2 8.9 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.6 ESA01308.1 - 0.078 12.4 17.5 0.15 11.5 1.3 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 CorA PF01544.13 ESA01308.1 - 0.096 11.7 6.8 1.8 7.5 2.1 2.2 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FliJ PF02050.11 ESA01308.1 - 0.096 12.7 7.4 0.07 13.1 3.2 2.0 1 1 1 2 2 2 0 Flagellar FliJ protein DASH_Dad3 PF08656.5 ESA01308.1 - 0.1 12.3 5.7 2.5 7.8 0.4 2.6 1 1 1 2 2 2 0 DASH complex subunit Dad3 PhaP_Bmeg PF09602.5 ESA01308.1 - 0.12 12.2 8.7 0.27 11.0 5.2 1.9 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Syntaxin_2 PF14523.1 ESA01308.1 - 0.12 12.4 16.2 0.45 10.5 6.0 2.5 1 1 1 2 2 2 0 Syntaxin-like protein Sec34 PF04136.10 ESA01308.1 - 0.12 12.1 6.4 0.39 10.3 3.9 2.1 1 1 1 2 2 2 0 Sec34-like family bZIP_2 PF07716.10 ESA01308.1 - 0.13 12.0 1.4 0.48 10.2 1.0 1.9 1 0 0 1 1 1 0 Basic region leucine zipper DUF3086 PF11285.3 ESA01308.1 - 0.14 10.9 4.5 0.19 10.5 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Hrs_helical PF12210.3 ESA01308.1 - 0.14 12.4 2.4 0.32 11.2 1.7 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF3552 PF12072.3 ESA01308.1 - 0.16 11.1 9.5 0.28 10.3 6.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Med4 PF10018.4 ESA01308.1 - 0.16 11.3 9.2 0.41 10.0 6.0 1.9 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Nup54 PF13874.1 ESA01308.1 - 0.16 11.5 8.7 0.076 12.6 3.6 1.9 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Atg14 PF10186.4 ESA01308.1 - 0.17 10.8 11.0 0.22 10.4 7.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 V-SNARE PF05008.10 ESA01308.1 - 0.18 12.0 5.7 0.2 11.8 1.8 2.4 1 1 1 2 2 1 0 Vesicle transport v-SNARE protein N-terminus Noelin-1 PF12308.3 ESA01308.1 - 0.19 11.5 3.5 0.25 11.1 1.8 1.7 1 1 1 2 2 1 0 Neurogenesis glycoprotein IncA PF04156.9 ESA01308.1 - 0.19 11.2 7.7 0.53 9.8 5.3 1.7 1 1 0 1 1 1 0 IncA protein PspA_IM30 PF04012.7 ESA01308.1 - 0.19 11.0 5.5 1.1 8.5 3.7 2.0 1 1 0 1 1 1 0 PspA/IM30 family Prefoldin_2 PF01920.15 ESA01308.1 - 0.2 11.4 15.6 1.4 8.7 3.0 3.5 2 1 3 5 5 4 0 Prefoldin subunit EMP24_GP25L PF01105.19 ESA01308.1 - 0.2 11.3 8.1 0.59 9.8 1.6 2.6 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD COG2 PF06148.6 ESA01308.1 - 0.2 11.5 4.5 0.31 10.9 2.5 1.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Vac_Fusion PF02346.11 ESA01308.1 - 0.21 11.0 5.7 2.3 7.6 0.8 2.5 1 1 1 2 2 2 0 Chordopoxvirus fusion protein DUF489 PF04356.7 ESA01308.1 - 0.24 10.9 5.5 0.5 9.9 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF489) BRI3BP PF14965.1 ESA01308.1 - 0.29 10.4 1.1 15 4.9 0.2 2.1 1 1 1 2 2 2 0 Negative regulator of p53/TP53 DUF2802 PF10975.3 ESA01308.1 - 0.3 10.8 5.5 2.6 7.8 0.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2802) GP41 PF00517.12 ESA01308.1 - 0.31 10.5 7.8 1.2 8.6 0.4 2.1 1 1 1 2 2 2 0 Retroviral envelope protein CENP-F_leu_zip PF10473.4 ESA01308.1 - 0.31 10.8 8.5 0.78 9.5 5.5 2.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fzo_mitofusin PF04799.8 ESA01308.1 - 0.32 10.3 9.3 0.13 11.6 1.8 2.2 1 1 1 2 2 2 0 fzo-like conserved region Snapin_Pallidin PF14712.1 ESA01308.1 - 0.34 11.2 9.0 0.83 10.0 2.5 2.6 1 1 2 3 3 3 0 Snapin/Pallidin MCPsignal PF00015.16 ESA01308.1 - 0.38 10.2 5.1 1.2 8.6 3.6 1.7 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4407 PF14362.1 ESA01308.1 - 0.4 9.5 8.5 0.51 9.2 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Syntaxin-6_N PF09177.6 ESA01308.1 - 0.47 10.9 8.9 1.2 9.5 4.0 2.8 1 1 2 3 3 3 0 Syntaxin 6, N-terminal PspB PF06667.7 ESA01308.1 - 0.48 10.3 2.2 3.8 7.5 0.1 2.7 1 1 0 2 2 2 0 Phage shock protein B CALCOCO1 PF07888.6 ESA01308.1 - 0.48 8.6 11.4 1.5 7.0 7.9 1.7 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like BRE1 PF08647.6 ESA01308.1 - 0.51 10.3 13.3 0.082 12.8 6.4 1.8 2 0 0 2 2 1 0 BRE1 E3 ubiquitin ligase DUF3573 PF12097.3 ESA01308.1 - 0.51 8.9 11.9 0.39 9.2 7.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Fmp27_WPPW PF10359.4 ESA01308.1 - 0.6 8.4 16.9 0.97 7.7 10.7 1.7 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain HsbA PF12296.3 ESA01308.1 - 0.61 9.9 9.8 0.38 10.6 0.8 2.9 1 1 1 2 2 2 0 Hydrophobic surface binding protein A Spectrin PF00435.16 ESA01308.1 - 0.71 10.1 5.5 1.2 9.4 1.9 2.4 1 1 1 2 2 2 0 Spectrin repeat ApoO PF09769.4 ESA01308.1 - 0.72 9.5 4.2 0.45 10.2 1.1 2.0 1 1 1 2 2 1 0 Apolipoprotein O GLE1 PF07817.8 ESA01308.1 - 0.93 8.3 10.6 0.085 11.7 0.5 2.2 1 1 1 2 2 2 0 GLE1-like protein TMF_DNA_bd PF12329.3 ESA01308.1 - 1 9.2 13.7 0.2 11.5 2.0 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 ESA01308.1 - 1 9.8 4.5 2.6 8.4 0.7 2.5 1 1 1 2 2 2 0 SlyX DUF2951 PF11166.3 ESA01308.1 - 1.1 9.1 10.3 2.1 8.2 4.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Tup_N PF08581.5 ESA01308.1 - 1.1 9.4 6.3 4.4 7.5 3.9 2.4 1 1 1 2 2 2 0 Tup N-terminal ALMT PF11744.3 ESA01308.1 - 1.2 7.7 6.2 1.5 7.4 4.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF972 PF06156.8 ESA01308.1 - 1.3 9.3 11.3 11 6.4 7.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF972) CENP-Q PF13094.1 ESA01308.1 - 1.4 8.9 12.1 3.8 7.5 5.4 2.3 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Nup88 PF10168.4 ESA01308.1 - 1.5 6.5 9.1 1.8 6.2 6.3 1.1 1 0 0 1 1 1 0 Nuclear pore component Uds1 PF15456.1 ESA01308.1 - 1.6 8.7 9.9 8.8 6.3 6.9 2.1 1 1 0 1 1 1 0 Up-regulated During Septation DUF16 PF01519.11 ESA01308.1 - 1.7 8.9 12.7 0.33 11.2 3.6 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Prominin PF05478.6 ESA01308.1 - 2 5.8 8.8 3.8 4.9 5.7 1.4 1 1 0 1 1 1 0 Prominin IFT57 PF10498.4 ESA01308.1 - 2.1 6.9 17.5 1.6 7.4 6.4 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF4482 PF14818.1 ESA01308.1 - 2.3 8.8 13.5 27 5.4 9.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) XhlA PF10779.4 ESA01308.1 - 2.4 8.1 18.4 0.084 12.8 2.9 3.0 2 1 1 3 3 2 0 Haemolysin XhlA DUF948 PF06103.6 ESA01308.1 - 2.5 8.0 9.2 3 7.7 2.5 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.17 ESA01308.1 - 2.7 8.0 11.3 0.78 9.7 4.0 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Flagellin_C PF00700.16 ESA01308.1 - 3.2 7.9 7.1 21 5.3 0.2 3.0 1 1 2 3 3 3 0 Bacterial flagellin C-terminal helical region DUF904 PF06005.7 ESA01308.1 - 3.2 8.0 10.6 3.4 8.0 6.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Striatin PF08232.7 ESA01308.1 - 3.3 8.0 15.7 43 4.4 10.9 2.3 1 1 0 1 1 1 0 Striatin family Osmo_CC PF08946.5 ESA01308.1 - 4.2 7.4 9.3 9 6.4 0.3 3.4 1 1 2 3 3 3 0 Osmosensory transporter coiled coil Occludin_ELL PF07303.8 ESA01308.1 - 5.1 7.8 13.4 1.8 9.3 4.2 2.4 1 1 1 2 2 2 0 Occludin homology domain Syntaxin PF00804.20 ESA01308.1 - 9.8 6.4 19.4 14 5.9 1.3 2.9 1 1 1 2 2 2 0 Syntaxin DUF4337 PF14235.1 ESA01308.1 - 9.9 5.9 8.9 0.42 10.4 0.9 2.0 1 1 1 2 2 1 0 Domain of unknown function (DUF4337) Peptidase_M16 PF00675.15 ESA01309.1 - 0.11 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) Pox_A28 PF04584.9 ESA01309.1 - 0.12 12.2 0.4 0.19 11.5 0.3 1.3 1 0 0 1 1 1 0 Poxvirus A28 family zf-C2H2 PF00096.21 ESA01310.1 - 3.1e-13 49.2 34.1 0.00045 20.3 0.6 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA01310.1 - 3.7e-12 45.8 27.1 0.0018 18.4 0.9 4.7 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA01310.1 - 3.2e-09 36.4 27.6 0.0052 17.0 2.4 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.2 ESA01310.1 - 8.1e-06 25.8 16.7 0.035 14.2 1.1 3.6 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESA01310.1 - 6.6e-05 22.9 22.0 0.0027 17.8 5.5 3.9 3 1 1 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 ESA01310.1 - 0.012 15.7 0.5 0.012 15.7 0.4 4.5 4 2 0 4 4 4 0 C2H2-type zinc-finger domain zf-FCS PF06467.9 ESA01310.1 - 0.083 12.5 0.6 0.083 12.5 0.4 2.8 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_6 PF13912.1 ESA01310.1 - 0.17 11.8 14.7 0.45 10.4 0.2 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESA01310.1 - 0.26 11.3 17.8 1.2 9.2 2.5 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.1 ESA01310.1 - 0.34 10.5 5.0 4.9 6.8 3.4 2.5 1 1 0 1 1 1 0 zinc-ribbon domain DUF2256 PF10013.4 ESA01310.1 - 0.79 9.5 4.5 1.1 9.0 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zinc_ribbon_4 PF13717.1 ESA01310.1 - 1.2 8.8 5.9 16 5.2 4.1 2.5 1 1 0 1 1 1 0 zinc-ribbon domain zf-C2HC_2 PF13913.1 ESA01310.1 - 1.5 8.5 13.7 6.7 6.5 1.3 4.2 4 0 0 4 4 4 0 zinc-finger of a C2HC-type HLH PF00010.21 ESA01311.1 - 1.6e-11 43.6 0.2 2.8e-11 42.9 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain APG17 PF04108.7 ESA01311.1 - 0.0031 16.3 2.0 0.0042 15.9 1.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 RE_TaqI PF09573.5 ESA01311.1 - 0.031 13.3 0.3 0.08 12.0 0.1 1.6 1 1 1 2 2 2 0 TaqI restriction endonuclease HSL_N PF06350.7 ESA01311.1 - 0.046 12.8 0.4 0.054 12.5 0.3 1.0 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus DUF4309 PF14172.1 ESA01312.1 - 0.0076 16.2 1.6 0.17 11.8 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4309) AA_permease_2 PF13520.1 ESA01313.1 - 0.006 15.1 1.4 0.0069 14.9 1.0 1.0 1 0 0 1 1 1 1 Amino acid permease Hpre_diP_synt_I PF07456.6 ESA01313.1 - 0.052 13.3 1.1 0.55 10.0 0.0 2.1 2 0 0 2 2 2 0 Heptaprenyl diphosphate synthase component I DUF4131 PF13567.1 ESA01313.1 - 0.065 12.6 0.2 0.078 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PPR_2 PF13041.1 ESA01314.1 - 1.2e-42 143.6 2.7 1.5e-14 53.6 0.0 8.1 3 1 5 8 8 8 8 PPR repeat family PPR_1 PF12854.2 ESA01314.1 - 2.7e-26 90.7 0.1 7.3e-05 22.1 0.0 8.1 9 0 0 9 9 9 5 PPR repeat PPR PF01535.15 ESA01314.1 - 3e-23 80.1 5.2 0.0011 18.8 0.0 9.4 10 0 0 10 10 10 6 PPR repeat PPR_3 PF13812.1 ESA01314.1 - 9.1e-20 69.2 4.6 0.00076 19.5 0.0 9.5 9 1 0 9 9 9 4 Pentatricopeptide repeat domain ECSIT PF06239.6 ESA01314.1 - 0.0046 15.8 0.9 11 4.8 0.0 3.9 3 1 0 4 4 4 1 Evolutionarily conserved signalling intermediate in Toll pathway zf-BED PF02892.10 ESA01317.1 - 8e-15 54.3 2.4 1.6e-14 53.3 1.6 1.5 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.10 ESA01317.1 - 0.014 14.8 0.2 0.037 13.4 0.1 1.7 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.2 ESA01317.1 - 0.027 14.5 0.6 0.067 13.3 0.4 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.4 ESA01317.1 - 0.11 12.3 0.3 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger domain DBD_Tnp_Hermes PF10683.4 ESA01317.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain zf-C2H2_4 PF13894.1 ESA01317.1 - 0.21 12.0 3.2 0.45 10.9 1.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger ATG27 PF09451.5 ESA01318.1 - 3.9e-39 134.4 0.8 7.3e-39 133.6 0.6 1.4 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.13 ESA01318.1 - 2.8e-07 30.4 1.8 0.013 15.3 0.1 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.10 ESA01318.1 - 0.00069 18.7 0.0 0.00097 18.2 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor DUF2633 PF11119.3 ESA01318.1 - 0.27 10.9 1.5 0.41 10.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2633) Aminotran_1_2 PF00155.16 ESA01319.1 - 2.5e-88 296.4 0.0 2.9e-88 296.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II BNR_3 PF13859.1 ESA01319.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 BNR repeat-like domain DWNN PF08783.6 ESA01322.1 - 2.2e-25 88.3 0.0 4.5e-25 87.3 0.0 1.6 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.1 ESA01322.1 - 2.3e-07 30.1 1.1 2.3e-07 30.1 0.7 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 ESA01322.1 - 0.00017 21.3 2.0 0.0005 19.8 1.4 1.8 1 0 0 1 1 1 1 Zinc knuckle TFIID-31kDa PF02291.10 ESA01322.1 - 0.11 12.3 0.2 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit zf-C3HC4_2 PF13923.1 ESA01322.1 - 1.1 9.3 20.2 0.11 12.5 9.3 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA01322.1 - 1.8 8.2 16.9 0.33 10.6 7.8 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.27 ESA01323.1 - 6.3e-21 73.4 15.1 1.9e-08 33.8 0.1 6.0 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 ESA01323.1 - 0.00035 18.8 0.3 0.011 13.9 0.0 2.7 2 1 0 2 2 2 2 Nucleoporin Nup120/160 IncA PF04156.9 ESA01323.1 - 0.34 10.4 3.5 0.64 9.5 2.5 1.5 1 0 0 1 1 1 0 IncA protein Ribosomal_L31e PF01198.14 ESA01324.1 - 8e-37 124.7 1.6 1e-36 124.4 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e SBDS_C PF09377.5 ESA01324.1 - 0.067 12.8 0.0 0.073 12.7 0.0 1.1 1 0 0 1 1 1 0 SBDS protein C-terminal domain RTC PF01137.16 ESA01325.1 - 2.7e-66 222.6 0.0 3.1e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 ESA01325.1 - 5.9e-33 112.9 0.0 8.8e-33 112.4 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Med28 PF11594.3 ESA01326.1 - 0.039 14.1 6.3 0.073 13.3 4.4 1.5 1 0 0 1 1 1 0 Mediator complex subunit 28 GKAP PF03359.8 ESA01326.1 - 0.05 13.2 1.3 0.066 12.8 0.9 1.2 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Cor1 PF04803.7 ESA01326.1 - 0.16 11.7 8.1 0.28 10.9 5.6 1.5 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region DUF3347 PF11827.3 ESA01326.1 - 0.33 10.9 2.5 0.36 10.7 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Spc42p PF11544.3 ESA01326.1 - 1.4 8.8 6.6 0.28 11.1 0.6 2.3 1 1 1 2 2 2 0 Spindle pole body component Spc42p Herpes_Helicase PF02689.9 ESA01327.1 - 0.038 11.7 0.0 0.041 11.6 0.0 1.0 1 0 0 1 1 1 0 Helicase F-box-like PF12937.2 ESA01330.1 - 0.00061 19.4 5.1 0.00083 19.0 0.3 3.2 3 0 0 3 3 3 1 F-box-like Med24_N PF11277.3 ESA01331.1 - 0.0007 17.2 0.2 0.00095 16.8 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal F-box-like PF12937.2 ESA01331.1 - 0.0024 17.5 1.0 0.01 15.5 0.7 2.0 1 0 0 1 1 1 1 F-box-like Baculo_gp41 PF04700.7 ESA01334.1 - 0.044 13.2 0.1 0.054 12.9 0.1 1.1 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region CheR_N PF03705.10 ESA01334.1 - 0.17 11.2 3.2 0.09 12.1 0.7 1.8 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain DUF496 PF04363.7 ESA01334.1 - 0.23 11.2 1.3 0.4 10.5 0.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF496) PP2C PF00481.16 ESA01335.1 - 6.2e-44 150.3 0.0 7.2e-44 150.0 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C Sec7 PF01369.15 ESA01337.1 - 2.5e-31 108.8 1.8 3.4e-31 108.3 0.2 2.0 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.1 ESA01337.1 - 9.7e-31 106.3 0.0 2.5e-30 105.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESA01337.1 - 0.00015 21.8 0.7 0.001 19.2 0.0 2.5 2 0 0 2 2 2 1 PH domain Syntaxin PF00804.20 ESA01338.1 - 0.066 13.3 0.5 0.77 9.9 0.1 2.8 3 0 0 3 3 3 0 Syntaxin DUF2346 PF09803.4 ESA01339.1 - 0.016 15.0 2.2 0.31 10.9 0.1 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) EH_Signature PF15611.1 ESA01342.1 - 0.012 14.6 0.1 0.013 14.6 0.1 1.1 1 0 0 1 1 1 0 EH_Signature domain Virulence_fact PF13769.1 ESA01342.1 - 0.014 15.2 0.8 0.33 10.8 0.2 2.1 2 0 0 2 2 2 0 Virulence factor MIF4G PF02854.14 ESA01342.1 - 0.018 14.4 3.0 0.16 11.3 0.1 2.3 2 1 0 2 2 2 0 MIF4G domain DUF2346 PF09803.4 ESA01342.1 - 0.11 12.4 0.5 3.1 7.7 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2346) SGS PF05002.10 ESA01342.1 - 4.1 7.2 6.1 1.4 8.7 0.4 2.2 1 1 1 2 2 2 0 SGS domain TLD PF07534.11 ESA01345.1 - 4.8e-12 46.0 0.6 5.5e-12 45.8 0.4 1.0 1 0 0 1 1 1 1 TLD TLD PF07534.11 ESA01346.1 - 8.7e-12 45.2 0.7 8.7e-12 45.2 0.5 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA01346.1 - 0.0069 16.2 0.6 0.32 10.8 0.1 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF285 PF03382.9 ESA01346.1 - 0.074 12.6 1.6 0.079 12.5 0.2 1.7 2 0 0 2 2 2 0 Mycoplasma protein of unknown function, DUF285 F-box-like PF12937.2 ESA01347.1 - 0.0011 18.6 0.1 0.0033 17.1 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA01348.1 - 0.00029 20.4 0.5 0.00092 18.8 0.4 1.8 1 0 0 1 1 1 1 F-box-like OTU PF02338.14 ESA01350.1 - 8.9e-14 52.1 0.0 1.5e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESA01350.1 - 0.0087 15.4 0.5 0.024 13.9 0.0 1.9 2 1 1 3 3 3 1 Peptidase C65 Otubain zf-UBP PF02148.14 ESA01350.1 - 0.035 14.2 1.6 0.051 13.7 0.4 1.8 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Ubiquitin_2 PF14560.1 ESA01351.1 - 0.09 13.0 0.1 0.17 12.1 0.1 1.5 1 1 0 1 1 1 0 Ubiquitin-like domain Apc13p PF05839.6 ESA01352.1 - 0.00016 21.6 8.2 0.024 14.6 0.3 2.9 1 1 1 2 2 2 2 Apc13p protein RNA_pol_Rpb4 PF03874.11 ESA01353.1 - 2.5e-22 79.1 6.9 4e-22 78.4 4.8 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 Phage_CP76 PF06892.6 ESA01353.1 - 0.017 14.4 0.4 0.11 11.7 0.0 2.0 2 0 0 2 2 2 0 Phage regulatory protein CII (CP76) EF-hand_8 PF13833.1 ESA01353.1 - 0.055 13.0 0.0 2.4 7.8 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain pair DUF603 PF04645.7 ESA01353.1 - 0.39 10.6 3.1 0.29 11.0 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function, DUF603 HHA PF05321.6 ESA01353.1 - 0.49 10.5 2.0 12 6.1 0.1 2.8 2 1 1 3 3 3 0 Haemolysin expression modulating protein Gln-synt_C PF00120.19 ESA01354.1 - 1.4e-63 214.4 0.0 5.4e-32 110.9 0.0 2.1 1 1 1 2 2 2 2 Glutamine synthetase, catalytic domain Abhydrolase_6 PF12697.2 ESA01355.1 - 2.4e-20 73.3 0.0 9.4e-20 71.4 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA01355.1 - 1.6e-09 37.6 0.2 3.2e-05 23.6 0.0 3.0 1 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA01355.1 - 2e-09 37.3 0.0 5.7e-09 35.8 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESA01355.1 - 0.0035 17.1 0.1 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_2 PF02230.11 ESA01355.1 - 0.007 15.8 0.0 0.69 9.3 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.13 ESA01355.1 - 0.01 15.1 0.0 0.044 13.0 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.8 ESA01355.1 - 0.012 15.1 0.0 0.046 13.1 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 ESA01355.1 - 0.012 14.8 0.0 4.1 6.5 0.0 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family PGAP1 PF07819.8 ESA01355.1 - 0.036 13.6 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2107 PF09880.4 ESA01355.1 - 0.042 13.7 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2107) ThiS PF02597.15 ESA01358.1 - 0.032 14.6 0.2 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 ThiS family HDA2-3 PF11496.3 ESA01362.1 - 0.027 13.2 0.7 0.67 8.7 0.0 2.2 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 LRR_4 PF12799.2 ESA01362.1 - 2.1 8.0 7.9 54 3.5 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) DUF3298 PF11738.3 ESA01363.1 - 0.42 11.1 2.4 0.36 11.3 0.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3298) DRIM PF07539.7 ESA01364.1 - 9.9e-47 157.9 1.6 2.5e-46 156.5 0.0 2.7 2 0 0 2 2 2 1 Down-regulated in metastasis BACK PF07707.10 ESA01365.1 - 4.3e-07 29.7 0.2 1.9e-05 24.4 0.1 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA01365.1 - 1.1e-06 28.6 0.1 0.00016 21.5 0.0 2.3 1 1 1 2 2 2 2 BTB/POZ domain bPH_3 PF14470.1 ESA01365.1 - 0.056 13.7 0.7 0.19 12.0 0.5 2.0 1 0 0 1 1 1 0 Bacterial PH domain Pkinase_Tyr PF07714.12 ESA01366.1 - 1.6e-05 24.0 0.0 6.7e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Plasmodium_Vir PF05795.6 ESA01366.1 - 0.0041 16.3 7.3 0.0054 15.9 5.1 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Peptidase_M18 PF02127.10 ESA01366.1 - 0.0042 15.6 0.1 0.0048 15.4 0.1 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) PDCD9 PF07147.7 ESA01366.1 - 0.013 14.3 0.1 0.016 14.0 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) Pkinase PF00069.20 ESA01366.1 - 0.023 13.8 0.1 0.069 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain TLD PF07534.11 ESA01367.1 - 1.5e-13 50.9 0.8 3.4e-13 49.7 0.6 1.7 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA01367.1 - 0.12 12.1 0.7 1.1 9.1 0.3 2.2 1 1 1 2 2 2 0 BTB And C-terminal Kelch Glyco_hydro_11 PF00457.12 ESA01370.1 - 0.02 14.2 0.4 0.045 13.0 0.3 1.7 1 1 0 1 1 1 0 Glycosyl hydrolases family 11 TSSC4 PF15264.1 ESA01370.1 - 0.15 12.5 0.6 5.8 7.3 0.1 2.3 2 0 0 2 2 2 0 Tumour suppressing sub-chromosomal transferable candidate 4 ERCC4 PF02732.10 ESA01372.1 - 8.2e-28 96.9 0.5 1.7e-27 95.9 0.4 1.6 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 ESA01372.1 - 0.012 15.7 0.0 0.037 14.2 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Eapp_C PF10238.4 ESA01373.1 - 2.4e-40 137.6 0.6 2.9e-40 137.3 0.4 1.1 1 0 0 1 1 1 1 E2F-associated phosphoprotein Yippee-Mis18 PF03226.9 ESA01373.1 - 0.00029 20.7 0.8 0.00044 20.2 0.6 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Lar_restr_allev PF14354.1 ESA01373.1 - 0.015 15.5 1.4 0.14 12.4 1.0 2.0 1 1 0 1 1 1 0 Restriction alleviation protein Lar Trm112p PF03966.11 ESA01373.1 - 0.019 15.3 0.4 0.071 13.4 0.3 1.9 1 1 0 1 1 1 0 Trm112p-like protein Prok-RING_1 PF14446.1 ESA01373.1 - 0.1 12.3 0.8 8.2 6.2 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 p450 PF00067.17 ESA01374.1 - 4.6e-77 259.4 0.1 5.1e-77 259.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 His_Phos_2 PF00328.17 ESA01374.1 - 0.059 12.7 0.1 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Kelch_4 PF13418.1 ESA01375.1 - 2.4e-08 33.6 5.6 0.029 14.1 0.2 4.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01375.1 - 5.5e-08 32.2 2.2 0.00061 19.4 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.1 ESA01375.1 - 9.8e-07 28.7 4.9 0.48 10.6 0.0 4.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA01375.1 - 1.4e-06 28.1 9.1 0.029 14.3 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.1 ESA01375.1 - 1.3e-05 25.1 8.7 0.0029 17.7 0.0 5.3 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.20 ESA01375.1 - 1.9e-05 24.0 14.1 0.001 18.5 0.1 4.7 5 0 0 5 5 5 3 Kelch motif CAP_C PF08603.6 ESA01376.1 - 0.047 13.0 4.5 0.69 9.2 0.1 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) C terminal Zn_ribbon_recom PF13408.1 ESA01376.1 - 0.3 11.3 2.3 0.69 10.2 1.6 1.7 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF2963 PF11178.3 ESA01376.1 - 7.2 6.1 14.0 16 4.9 0.8 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2963) LRR_8 PF13855.1 ESA01377.1 - 8.9e-07 28.5 2.8 1.4e-06 27.9 0.7 2.4 2 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 ESA01377.1 - 3e-05 23.5 3.0 0.02 14.5 0.1 3.4 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA01377.1 - 0.0007 19.4 7.4 0.4 10.8 0.0 5.0 5 0 0 5 5 5 1 Leucine Rich repeat Peptidase_M90 PF06167.7 ESA01381.1 - 0.04 13.3 0.1 0.055 12.8 0.1 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 VWA_3 PF13768.1 ESA01383.1 - 2.4e-29 102.0 0.0 3.6e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 ESA01383.1 - 4.4e-19 68.2 1.4 8.6e-19 67.3 1.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.23 ESA01383.1 - 9.8e-16 57.9 0.0 1.8e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA01383.1 - 1.4e-11 44.8 0.0 2.2e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESA01383.1 - 4.7e-09 35.5 0.1 9.7e-09 34.5 0.1 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain vWA-TerF-like PF10138.4 ESA01383.1 - 0.00011 22.1 0.1 0.00028 20.7 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus BTB PF00651.26 ESA01384.1 - 1.5e-19 70.0 0.4 3.3e-19 68.9 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain Gal4_dimer PF03902.8 ESA01384.1 - 0.12 12.2 0.9 5.6 6.9 0.0 3.3 3 0 0 3 3 3 0 Gal4-like dimerisation domain GCC2_GCC3 PF07699.8 ESA01385.1 - 0.012 15.1 0.6 0.012 15.1 0.4 7.6 6 4 4 10 10 10 0 GCC2 and GCC3 Redoxin PF08534.5 ESA01385.1 - 0.068 12.7 0.3 38 3.7 0.0 4.2 4 0 0 4 4 4 0 Redoxin Ldh_2 PF02615.9 ESA01385.1 - 0.068 11.8 2.8 0.27 9.9 0.3 2.2 2 0 0 2 2 2 0 Malate/L-lactate dehydrogenase DZR PF12773.2 ESA01385.1 - 0.16 11.8 32.8 1.2 8.9 1.2 5.3 5 0 0 5 5 5 0 Double zinc ribbon DUF2457 PF10446.4 ESA01385.1 - 0.85 8.2 10.4 1.5 7.4 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3279 PF11682.3 ESA01385.1 - 3.4 7.2 29.8 0.19 11.2 0.2 5.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3279) Pkinase_Tyr PF07714.12 ESA01386.1 - 5.2e-08 32.2 0.0 6.3e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01386.1 - 0.00017 20.8 0.0 0.0002 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF1878 PF08963.5 ESA01386.1 - 0.13 12.5 0.1 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) Cullin_binding PF03556.10 ESA01388.1 - 0.0053 16.8 1.0 0.019 15.1 0.4 1.8 1 1 1 2 2 2 1 Cullin binding PT-VENN PF04829.8 ESA01389.1 - 0.73 9.4 7.3 2.4 7.7 0.4 2.2 1 1 1 2 2 2 0 Pre-toxin domain with VENN motif RNase_H PF00075.19 ESA01392.1 - 2.3e-09 37.6 4.7 6.5e-09 36.2 1.7 1.9 1 1 1 2 2 2 2 RNase H Peptidase_A17 PF05380.8 ESA01393.1 - 0.12 12.2 0.2 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Pao retrotransposon peptidase DNA_pol3_a_NI PF14480.1 ESA01393.1 - 0.65 9.6 3.5 0.5 10.0 0.3 2.0 1 1 1 2 2 2 0 DNA polymerase III polC-type N-terminus I MULE PF10551.4 ESA01394.1 - 1.5e-06 28.2 0.0 3.9e-06 26.9 0.0 1.8 1 1 0 1 1 1 1 MULE transposase domain DUF914 PF06027.7 ESA01397.1 - 0.068 12.0 0.1 0.081 11.7 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) YLP PF02757.12 ESA01397.1 - 0.07 12.7 0.4 0.15 11.8 0.3 1.5 1 0 0 1 1 1 0 YLP motif DUF3007 PF11460.3 ESA01397.1 - 0.14 12.2 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) DUF3552 PF12072.3 ESA01402.1 - 0.016 14.3 0.8 0.026 13.7 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spc24 PF08286.6 ESA01402.1 - 0.063 12.9 0.9 0.099 12.3 0.6 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 APG6 PF04111.7 ESA01402.1 - 0.068 12.2 4.6 0.085 11.8 3.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_2 PF07716.10 ESA01402.1 - 0.26 11.1 3.6 29 4.5 2.5 2.5 1 1 0 1 1 1 0 Basic region leucine zipper DUF972 PF06156.8 ESA01402.1 - 0.39 11.0 3.4 0.69 10.2 2.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF972) KfrA_N PF11740.3 ESA01402.1 - 0.49 10.8 3.3 0.76 10.2 2.3 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DivIC PF04977.10 ESA01402.1 - 0.66 9.4 3.2 1.5 8.3 2.2 1.6 1 1 0 1 1 1 0 Septum formation initiator IL33 PF15095.1 ESA01405.1 - 0.02 14.3 0.0 0.023 14.1 0.0 1.0 1 0 0 1 1 1 0 Interleukin 33 W_rich_C PF07483.6 ESA01405.1 - 0.13 11.9 0.3 0.64 9.7 0.1 1.9 1 1 1 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain DUF4508 PF14969.1 ESA01406.1 - 0.069 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) Rep_4 PF05797.6 ESA01407.1 - 0.021 13.5 0.3 0.024 13.3 0.2 1.0 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) ESAG1 PF03238.8 ESA01407.1 - 0.076 12.3 1.7 0.098 11.9 1.2 1.1 1 0 0 1 1 1 0 ESAG protein ubiquitin PF00240.18 ESA01408.1 - 0.077 12.4 0.1 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Ubiquitin family DUF465 PF04325.8 ESA01409.1 - 0.02 14.5 2.6 0.93 9.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF465) MACPF PF01823.14 ESA01413.1 - 5.5e-08 32.7 2.3 5.5e-08 32.7 1.6 2.0 1 1 1 2 2 2 1 MAC/Perforin domain MACPF PF01823.14 ESA01414.1 - 6e-08 32.6 3.4 9.4e-08 31.9 2.3 1.3 1 0 0 1 1 1 1 MAC/Perforin domain DUF2423 PF10338.4 ESA01414.1 - 0.81 9.7 4.2 2.2 8.3 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Pkinase_Tyr PF07714.12 ESA01417.1 - 3.5e-37 127.9 0.1 6.4e-37 127.0 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01417.1 - 1.3e-31 109.7 0.7 1.7e-31 109.2 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA01417.1 - 1.7e-05 23.9 0.0 2.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AIB PF15334.1 ESA01417.1 - 0.029 13.4 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Aurora kinase A and ninein interacting protein MACPF PF01823.14 ESA01420.1 - 0.00012 21.8 6.5 0.00046 19.9 4.5 2.0 1 1 0 1 1 1 1 MAC/Perforin domain FAR1 PF03101.10 ESA01421.1 - 1.1e-09 38.6 1.8 1.1e-09 38.6 1.2 2.8 2 0 0 2 2 2 1 FAR1 DNA-binding domain MULE PF10551.4 ESA01421.1 - 8.9e-08 32.2 0.1 2.8e-07 30.6 0.1 1.9 1 0 0 1 1 1 1 MULE transposase domain BTB PF00651.26 ESA01425.1 - 4.4e-18 65.2 0.8 8.1e-18 64.4 0.2 1.6 1 1 1 2 2 2 1 BTB/POZ domain DUF667 PF05018.8 ESA01425.1 - 0.037 13.2 0.1 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF667) Far-17a_AIG1 PF04750.9 ESA01426.1 - 2.8e-07 29.9 15.2 3.5e-07 29.5 10.6 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Sel1 PF08238.7 ESA01428.1 - 5.9e-47 157.0 14.0 9.3e-13 48.3 0.5 4.5 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA01428.1 - 5e-05 23.4 8.1 0.76 10.3 0.0 4.2 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA01428.1 - 0.0021 17.6 19.3 0.047 13.3 1.6 4.2 1 1 4 5 5 5 4 TPR repeat MIT PF04212.13 ESA01428.1 - 0.025 14.4 8.4 1.1 9.1 0.5 3.4 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA01428.1 - 0.031 14.3 0.5 9 6.4 0.0 2.7 1 1 2 3 3 3 0 Predicted AdoMet-dependent methyltransferase TPR_16 PF13432.1 ESA01428.1 - 0.033 14.8 1.7 1.6 9.4 0.1 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat CAT_RBD PF03123.10 ESA01428.1 - 0.043 13.5 0.2 0.84 9.3 0.0 2.5 2 0 0 2 2 2 0 CAT RNA binding domain TPR_17 PF13431.1 ESA01428.1 - 0.19 12.0 6.7 30 5.1 0.3 5.0 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA01428.1 - 0.2 11.6 12.8 9.4 6.2 0.3 4.4 1 1 3 4 4 4 0 Tetratricopeptide repeat DUF2235 PF09994.4 ESA01428.1 - 0.24 10.7 1.0 6.2 6.1 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) GATase_2 PF00310.16 ESA01429.1 - 2e-13 49.8 0.1 1.1e-06 27.6 0.0 2.0 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 ESA01429.1 - 0.00089 19.2 0.0 0.0015 18.5 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase domain zf-CCHC PF00098.18 ESA01430.1 - 0.0033 17.2 2.8 0.0075 16.1 1.9 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 ESA01430.1 - 0.0034 17.0 0.6 0.0094 15.5 0.4 1.8 1 0 0 1 1 1 1 Zinc knuckle Myb_DNA-bind_4 PF13837.1 ESA01431.1 - 0.0012 18.9 7.7 0.0012 18.9 5.3 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Daxx PF03344.10 ESA01431.1 - 0.12 10.8 10.1 0.16 10.4 7.0 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 ESA01431.1 - 0.17 9.7 10.4 0.21 9.5 7.2 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA01431.1 - 1.4 6.8 13.5 0.31 9.0 7.4 1.3 2 0 0 2 2 2 0 CDC45-like protein cwf18 PF08315.7 ESA01432.1 - 5e-32 111.0 16.5 8.1e-32 110.3 11.4 1.3 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor DUF2972 PF11186.3 ESA01432.1 - 0.02 14.8 9.0 0.04 13.8 4.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2972) TPM PF04536.9 ESA01432.1 - 0.035 13.9 1.4 0.11 12.3 0.3 1.9 2 0 0 2 2 2 0 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase Ribosomal_S30AE PF02482.14 ESA01432.1 - 0.051 14.0 2.8 1.6 9.2 0.1 2.4 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DUF262 PF03235.9 ESA01432.1 - 1.1 9.1 10.3 1.7 8.5 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF2501 PF10696.4 ESA01433.1 - 0.099 12.6 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2501) DUF3692 PF12469.3 ESA01434.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein Vac14_Fig4_bd PF11916.3 ESA01435.1 - 5.5e-83 276.5 6.7 5.5e-83 276.5 4.6 1.8 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 ESA01435.1 - 5.2e-48 161.4 1.9 9.5e-43 144.5 0.0 4.2 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 ESA01435.1 - 2.2e-14 52.1 2.3 0.00086 19.1 0.0 7.5 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.1 ESA01435.1 - 4e-09 36.6 1.1 0.075 13.3 0.1 6.2 6 2 0 6 6 6 2 HEAT repeats HEAT_EZ PF13513.1 ESA01435.1 - 1.3e-06 28.6 0.7 0.027 14.9 0.0 5.2 6 0 0 6 6 6 2 HEAT-like repeat Arm PF00514.18 ESA01435.1 - 0.0001 21.9 0.0 6.3 6.7 0.0 5.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.2 ESA01435.1 - 0.0048 16.7 9.0 0.094 12.5 0.0 4.3 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.4 ESA01435.1 - 0.068 13.0 4.3 1.6 8.6 0.0 4.0 4 2 1 5 5 5 0 Parkin co-regulated protein BNR PF02012.15 ESA01436.1 - 0.0003 20.1 48.2 0.5 10.4 0.3 11.4 11 0 0 11 11 11 7 BNR/Asp-box repeat DUF2003 PF09404.5 ESA01437.1 - 1.5e-26 92.8 1.1 3.3e-25 88.4 0.8 2.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF2003) tRNA_anti-codon PF01336.20 ESA01438.1 - 0.00036 20.3 0.9 0.73 9.7 0.1 4.0 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain Septin PF00735.13 ESA01439.1 - 2.9e-127 423.5 1.2 2.9e-127 423.5 0.8 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 ESA01439.1 - 1e-08 35.1 0.0 2.7e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA01439.1 - 1.4e-06 28.6 5.9 8.6e-05 22.8 0.0 3.2 2 1 0 2 2 2 1 ABC transporter DUF258 PF03193.11 ESA01439.1 - 2.5e-06 26.7 0.2 9.2e-06 24.9 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESA01439.1 - 5.4e-06 25.9 1.4 0.00029 20.3 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.11 ESA01439.1 - 3.1e-05 23.1 0.0 3.1e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 AIG1 family AAA_10 PF12846.2 ESA01439.1 - 0.00068 19.1 1.9 0.0055 16.1 0.0 2.5 1 1 1 3 3 3 1 AAA-like domain Ras PF00071.17 ESA01439.1 - 0.002 17.5 0.3 0.0071 15.7 0.0 2.1 2 0 0 2 2 2 1 Ras family Miro PF08477.8 ESA01439.1 - 0.0051 17.3 2.3 0.0075 16.7 0.0 2.4 2 1 0 2 2 2 1 Miro-like protein AAA_29 PF13555.1 ESA01439.1 - 0.0073 15.8 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESA01439.1 - 0.014 15.3 4.3 0.079 12.9 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.1 ESA01439.1 - 0.015 14.9 1.4 0.025 14.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 ESA01439.1 - 0.023 14.5 10.7 0.12 12.1 0.1 3.5 2 2 1 3 3 2 0 Dynamin family AAA_22 PF13401.1 ESA01439.1 - 0.032 14.3 1.4 0.083 13.0 0.1 2.5 2 2 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA01439.1 - 0.058 12.8 0.0 1.3 8.5 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 ESA01439.1 - 0.072 12.4 0.2 0.51 9.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA01439.1 - 0.1 12.0 0.1 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.17 ESA01439.1 - 0.12 12.5 1.7 0.72 10.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.1 ESA01439.1 - 0.3 11.3 21.1 1.4e+02 2.6 14.6 2.4 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 ESA01439.1 - 5.8 6.3 7.8 9.1 5.7 0.1 3.6 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Exonuc_VII_L PF02601.10 ESA01439.1 - 6 5.9 17.1 1.9 7.6 8.7 2.2 2 1 0 2 2 2 0 Exonuclease VII, large subunit Rhabdo_ncap PF00945.13 ESA01440.1 - 0.074 11.6 0.0 0.075 11.6 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein TPP_enzyme_M PF00205.17 ESA01441.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Methyltrn_RNA_3 PF02598.12 ESA01443.1 - 1.1e-57 195.6 0.0 1.4e-57 195.3 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase YEATS PF03366.11 ESA01444.1 - 5.8e-24 83.6 0.7 1.2e-23 82.5 0.5 1.6 1 0 0 1 1 1 1 YEATS family RRM_1 PF00076.17 ESA01445.1 - 5.2e-41 138.1 0.4 6.3e-20 70.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA01445.1 - 7.1e-35 118.8 0.0 3.4e-16 58.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA01445.1 - 5.8e-19 67.6 0.0 8e-09 35.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA01445.1 - 0.00032 20.3 0.1 0.11 12.2 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RNF111_N PF15303.1 ESA01446.1 - 0.82 9.1 9.5 1 8.8 6.6 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus PAT1 PF09770.4 ESA01447.1 - 6.1e-05 21.4 24.1 6.1e-05 21.4 16.7 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Lsr2 PF11774.3 ESA01447.1 - 0.31 10.9 5.9 0.72 9.8 4.1 1.6 1 0 0 1 1 1 0 Lsr2 Auxin_canalis PF05703.6 ESA01447.1 - 0.6 9.8 3.4 0.59 9.9 2.3 1.2 1 0 0 1 1 1 0 Auxin canalisation Pex14_N PF04695.8 ESA01447.1 - 1.2 9.1 14.6 2.4 8.2 10.2 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gti1_Pac2 PF09729.4 ESA01447.1 - 2.1 8.1 9.1 3.4 7.5 6.3 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family CRF1 PF10380.4 ESA01447.1 - 2.4 8.4 6.6 4.3 7.6 4.6 1.6 1 0 0 1 1 1 0 Transcription factor CRF1 V_ATPase_I PF01496.14 ESA01447.1 - 2.6 5.7 7.3 2.2 6.0 5.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lipase_GDSL_3 PF14606.1 ESA01447.1 - 3.3 7.4 6.0 5 6.8 4.2 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family YABBY PF04690.8 ESA01447.1 - 3.7 7.7 12.2 5.4 7.2 8.5 1.3 1 0 0 1 1 1 0 YABBY protein MCPVI PF02993.9 ESA01447.1 - 3.9 7.5 14.4 1 9.4 8.1 1.4 2 0 0 2 2 2 0 Minor capsid protein VI TFIIA PF03153.8 ESA01447.1 - 4.4 7.1 27.5 5.8 6.7 19.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ctr PF04145.10 ESA01447.1 - 4.5 7.3 8.0 1.1 9.3 3.5 1.6 2 0 0 2 2 2 0 Ctr copper transporter family DUF4557 PF15101.1 ESA01447.1 - 4.6 7.0 31.5 0.59 9.9 19.2 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) RNA_pol_Rpb1_2 PF00623.15 ESA01447.1 - 4.8 7.1 8.3 8 6.3 5.8 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 2 HlyD_2 PF12700.2 ESA01447.1 - 4.8 6.2 13.2 6.2 5.8 9.1 1.3 1 0 0 1 1 1 0 HlyD family secretion protein RED_N PF07808.8 ESA01447.1 - 5 6.2 25.2 6.9 5.8 15.5 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region DUF3373 PF11853.3 ESA01447.1 - 6 5.2 9.4 5.3 5.4 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF4638 PF15472.1 ESA01447.1 - 6.4 6.2 14.6 11 5.5 10.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Hid1 PF12722.2 ESA01447.1 - 7.2 4.1 17.1 9.3 3.7 11.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PIG-S PF10510.4 ESA01447.1 - 7.4 5.1 15.0 8.9 4.8 10.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Glyco_transf_15 PF01793.11 ESA01447.1 - 9.6 5.0 13.1 15 4.4 9.1 1.3 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase LNP1 PF15419.1 ESA01448.1 - 0.04 14.0 1.9 0.063 13.3 1.3 1.3 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 Sec7_N PF12783.2 ESA01449.1 - 3.1e-43 147.0 7.3 1.8e-40 138.0 2.3 3.3 3 0 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 ESA01449.1 - 0.00032 20.1 0.5 0.0016 17.9 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) FHA PF00498.21 ESA01450.1 - 7.9e-15 54.7 0.1 1.5e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.1 ESA01450.1 - 7.9e-09 35.2 15.8 1.3e-08 34.5 11.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA01450.1 - 7.2e-05 22.8 7.5 0.00015 21.8 5.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger BRX PF08381.6 ESA01450.1 - 0.013 14.5 0.1 0.028 13.4 0.0 1.5 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 Rtf2 PF04641.7 ESA01450.1 - 0.03 13.5 0.1 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_5 PF14634.1 ESA01450.1 - 0.03 14.0 13.7 0.068 12.9 9.5 1.6 1 1 0 1 1 1 0 zinc-RING finger domain zf-Apc11 PF12861.2 ESA01450.1 - 0.04 13.7 6.0 0.069 12.9 4.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESA01450.1 - 0.084 12.5 15.3 0.16 11.6 10.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA01450.1 - 0.96 9.5 18.0 1.7 8.7 12.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-BED PF02892.10 ESA01455.1 - 8.9e-07 28.5 1.7 8.9e-07 28.5 1.2 1.7 2 0 0 2 2 2 1 BED zinc finger PyrI_C PF02748.10 ESA01455.1 - 0.16 11.4 1.3 0.19 11.2 0.1 1.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DEAD PF00270.24 ESA01456.1 - 2.5e-40 137.7 0.0 4.4e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA01456.1 - 9.7e-24 83.0 0.1 2.2e-23 81.8 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.1 ESA01456.1 - 0.12 11.4 0.1 0.12 11.4 0.1 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Ribosomal_L18e PF00828.14 ESA01457.1 - 1.2e-22 80.5 0.0 2e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Pkinase_Tyr PF07714.12 ESA01459.1 - 4.7e-07 29.1 0.0 5.5e-07 28.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01459.1 - 2.8e-06 26.6 0.0 3.2e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Laminin_II PF06009.7 ESA01460.1 - 0.00086 19.0 4.0 0.00096 18.9 0.2 2.1 2 0 0 2 2 2 1 Laminin Domain II Baculo_PEP_C PF04513.7 ESA01460.1 - 0.0058 16.4 1.5 0.013 15.2 0.1 1.9 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_I PF06008.9 ESA01460.1 - 0.021 14.1 0.5 0.021 14.1 0.3 1.5 2 0 0 2 2 2 0 Laminin Domain I DUF1247 PF06851.6 ESA01460.1 - 0.026 14.1 2.3 0.028 14.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) TPR_MLP1_2 PF07926.7 ESA01460.1 - 0.034 13.8 1.6 0.034 13.8 1.1 1.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein COG2 PF06148.6 ESA01460.1 - 0.035 13.9 1.1 0.075 12.9 0.0 1.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 GSH_synth_ATP PF03917.12 ESA01460.1 - 0.094 11.2 1.4 0.14 10.7 0.8 1.3 1 1 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain GvpK PF05121.7 ESA01460.1 - 0.2 11.4 1.0 0.51 10.2 0.1 1.9 2 0 0 2 2 2 0 Gas vesicle protein K Scaffolding_pro PF11418.3 ESA01460.1 - 0.22 11.8 3.1 0.099 12.9 0.5 1.6 2 0 0 2 2 2 0 Phi29 scaffolding protein Bul1_C PF04426.7 ESA01460.1 - 0.51 9.4 7.6 0.31 10.2 0.4 2.1 2 0 0 2 2 2 0 Bul1 C terminus DUF1664 PF07889.7 ESA01460.1 - 1 9.2 3.8 0.75 9.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.5 ESA01460.1 - 6.4 6.8 8.1 2.2 8.3 0.5 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family UPF0147 PF03685.8 ESA01462.1 - 0.019 14.8 0.3 0.14 12.0 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0147) Mod_r PF07200.8 ESA01462.1 - 0.058 13.3 3.5 0.14 12.0 2.4 1.6 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Sec23_helical PF04815.10 ESA01465.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Sex_peptide PF08138.6 ESA01465.1 - 0.085 12.7 0.1 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Sex peptide (SP) family MIF4G PF02854.14 ESA01467.1 - 5.7e-40 136.9 6.5 7.1e-40 136.6 4.5 1.1 1 0 0 1 1 1 1 MIF4G domain TFIIIC_delta PF12657.2 ESA01468.1 - 7.8e-23 81.0 0.3 1.7e-22 79.9 0.2 1.5 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term N-glycanase_C PF09113.5 ESA01468.1 - 0.0029 17.2 0.8 0.0046 16.6 0.6 1.3 1 0 0 1 1 1 1 Peptide-N-glycosidase F, C terminal p450 PF00067.17 ESA01471.1 - 2.6e-37 128.4 0.0 3e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA01471.1 - 0.014 15.3 0.1 0.03 14.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1811) IBR PF01485.16 ESA01472.1 - 2.9e-17 62.2 40.7 1.8e-09 37.3 8.0 4.2 3 1 1 4 4 4 3 IBR domain zf-C3HC4_3 PF13920.1 ESA01472.1 - 8.8 6.0 40.5 0.08 12.6 6.3 4.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) ubiquitin PF00240.18 ESA01473.1 - 4.1e-28 96.5 0.5 8.2e-15 53.9 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA01473.1 - 2.2e-09 36.8 0.2 1.1e-05 25.0 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA01473.1 - 0.00068 19.8 0.8 1.4 9.2 0.2 3.0 2 1 0 2 2 2 2 Ubiquitin-like domain DUF2240 PF09999.4 ESA01473.1 - 0.058 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) DivIC PF04977.10 ESA01473.1 - 0.074 12.5 1.0 0.2 11.1 0.7 1.7 1 0 0 1 1 1 0 Septum formation initiator DUF1359 PF07097.6 ESA01473.1 - 0.13 12.2 0.8 0.24 11.4 0.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1359) DUF904 PF06005.7 ESA01473.1 - 0.46 10.8 4.3 0.21 11.9 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Ribosomal_L31 PF01197.13 ESA01474.1 - 5.9e-06 26.1 0.0 9e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L31 BTB PF00651.26 ESA01475.1 - 8.1e-19 67.6 0.1 1.9e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01475.1 - 1.1e-11 44.5 6.0 1e-07 31.6 0.5 4.6 4 1 1 5 5 5 3 BTB And C-terminal Kelch KLRAQ PF10205.4 ESA01476.1 - 0.00096 19.1 9.3 0.11 12.5 3.9 2.3 1 1 1 2 2 2 2 Predicted coiled-coil domain-containing protein Kinesin-relat_1 PF12711.2 ESA01476.1 - 0.0025 18.1 3.6 0.2 12.0 0.1 3.2 1 1 2 3 3 3 1 Kinesin motor Cep57_CLD_2 PF14197.1 ESA01476.1 - 0.0062 16.4 11.8 0.064 13.2 6.5 3.0 1 1 2 3 3 3 1 Centrosome localisation domain of PPC89 HALZ PF02183.13 ESA01476.1 - 0.023 14.3 9.8 0.56 9.9 0.1 3.6 1 1 2 3 3 3 0 Homeobox associated leucine zipper DUF1090 PF06476.7 ESA01476.1 - 0.03 13.9 2.7 0.066 12.8 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) bZIP_1 PF00170.16 ESA01476.1 - 0.69 9.9 11.4 0.37 10.7 0.6 2.9 2 1 0 2 2 2 0 bZIP transcription factor DivIC PF04977.10 ESA01476.1 - 1.4 8.4 13.3 0.73 9.3 0.9 3.8 2 1 1 3 3 3 0 Septum formation initiator TMF_TATA_bd PF12325.3 ESA01476.1 - 1.4 8.6 12.4 1.1 8.9 2.0 3.0 1 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 ESA01476.1 - 3.7 7.8 19.4 14 6.0 2.8 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF904) IncA PF04156.9 ESA01476.1 - 4.8 6.7 13.2 8.4 5.9 9.1 1.5 1 1 0 1 1 1 0 IncA protein DUF724 PF05266.9 ESA01476.1 - 7.3 6.1 10.5 12 5.4 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF972 PF06156.8 ESA01476.1 - 7.8 6.8 11.2 8.1 6.8 2.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF972) HTH_42 PF06224.7 ESA01477.1 - 0.023 14.0 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain Phasin_2 PF09361.5 ESA01477.1 - 0.077 13.0 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 Phasin protein Pkinase_Tyr PF07714.12 ESA01479.1 - 0.098 11.7 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase RRM_1 PF00076.17 ESA01481.1 - 0.11 12.2 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol_viral_N PF00242.12 ESA01481.1 - 0.12 11.4 13.6 0.15 11.0 9.4 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Syntaxin-6_N PF09177.6 ESA01481.1 - 0.25 11.7 0.0 0.25 11.7 0.0 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SlyX PF04102.7 ESA01481.1 - 0.59 10.5 4.5 1.5 9.2 0.3 3.1 2 1 0 2 2 2 0 SlyX Hid1 PF12722.2 ESA01481.1 - 2.5 5.6 15.4 3 5.4 10.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.4 ESA01481.1 - 2.5 6.2 17.7 3.4 5.8 12.3 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF2217 PF10265.4 ESA01481.1 - 5.2 5.7 6.7 5.9 5.5 4.7 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Ndc1_Nup PF09531.5 ESA01481.1 - 5.2 5.3 10.5 6.6 5.0 7.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1731 PF08338.6 ESA01482.1 - 0.084 12.3 0.3 0.22 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1731) WD40_alt PF14077.1 ESA01483.1 - 0.042 13.4 0.2 0.067 12.8 0.2 1.3 1 0 0 1 1 1 0 Alternative WD40 repeat motif RNA_Me_trans PF04252.8 ESA01486.1 - 0.012 15.0 0.2 0.074 12.4 0.1 1.9 1 1 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase TaqI_C PF12950.2 ESA01486.1 - 0.029 14.1 1.6 0.037 13.7 1.1 1.2 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain MIR PF02815.14 ESA01488.1 - 4.5e-06 26.3 2.4 0.029 13.9 1.1 2.4 1 1 1 2 2 2 2 MIR domain Pox_A32 PF04665.7 ESA01490.1 - 0.00018 20.8 0.0 0.037 13.3 0.0 2.1 2 0 0 2 2 2 2 Poxvirus A32 protein Tropomyosin_1 PF12718.2 ESA01491.1 - 0.00044 20.1 11.6 0.11 12.4 7.3 2.7 1 1 2 3 3 3 2 Tropomyosin like Pox_A_type_inc PF04508.7 ESA01491.1 - 0.014 15.1 9.4 7.3 6.6 0.1 4.4 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat MutS_III PF05192.13 ESA01491.1 - 0.018 14.7 0.1 0.021 14.6 0.1 1.3 1 0 0 1 1 1 0 MutS domain III DUF2066 PF09839.4 ESA01491.1 - 0.047 12.8 0.0 0.087 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2066) DUF641 PF04859.7 ESA01491.1 - 0.067 12.9 4.0 0.046 13.4 1.2 1.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) WD40_alt PF14077.1 ESA01491.1 - 0.075 12.6 4.5 1.2 8.8 0.0 3.2 2 1 0 3 3 3 0 Alternative WD40 repeat motif DUF2357 PF09823.4 ESA01491.1 - 0.1 11.6 2.9 0.78 8.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2357) Myosin_tail_1 PF01576.14 ESA01491.1 - 0.18 9.5 10.8 0.91 7.1 7.5 1.7 1 1 0 1 1 1 0 Myosin tail GvpK PF05121.7 ESA01491.1 - 0.33 10.8 4.8 0.7 9.7 1.5 2.7 1 1 2 3 3 3 0 Gas vesicle protein K Laminin_II PF06009.7 ESA01491.1 - 2.4 7.9 11.5 1.6 8.4 0.2 2.5 1 1 2 3 3 3 0 Laminin Domain II FlaC_arch PF05377.6 ESA01491.1 - 7.1 6.6 9.1 14 5.6 0.3 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Methyltransf_31 PF13847.1 ESA01492.1 - 0.34 10.5 0.0 0.34 10.5 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain LRR_7 PF13504.1 ESA01492.1 - 1.8 9.0 4.2 15 6.3 0.1 3.6 2 1 0 2 2 2 0 Leucine rich repeat LRR_4 PF12799.2 ESA01492.1 - 8.4 6.1 17.0 0.22 11.2 0.3 4.4 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) DUF2132 PF09905.4 ESA01493.1 - 0.044 13.7 0.1 1.2 9.0 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2132) PXA PF02194.10 ESA01494.1 - 0.023 14.2 2.3 0.039 13.5 1.6 1.3 1 0 0 1 1 1 0 PXA domain DUF4346 PF14251.1 ESA01494.1 - 0.26 11.0 2.4 1.8 8.3 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4346) Rad60-SLD PF11976.3 ESA01497.1 - 1.6e-14 53.3 1.0 1.9e-14 53.0 0.2 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESA01497.1 - 4.3e-07 29.2 0.1 6.1e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Dimer_Tnp_hAT PF05699.9 ESA01498.1 - 1.2e-08 34.4 0.2 2.9e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA01498.1 - 0.0077 15.7 0.0 0.02 14.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) MULE PF10551.4 ESA01498.1 - 0.038 14.1 0.0 1.1 9.5 0.0 2.5 1 1 1 2 2 2 0 MULE transposase domain zf-CCHC PF00098.18 ESA01499.1 - 6.8e-21 73.1 104.9 8.8e-06 25.4 2.5 10.8 6 3 4 10 10 10 10 Zinc knuckle zf-CCHC_4 PF14392.1 ESA01499.1 - 0.00021 20.9 15.3 0.003 17.2 3.3 9.2 2 2 8 10 10 10 6 Zinc knuckle BTB PF00651.26 ESA01500.1 - 0.0013 18.7 0.0 0.0016 18.4 0.0 1.3 1 1 0 1 1 1 1 BTB/POZ domain Omega-toxin PF06357.6 ESA01500.1 - 1.9 8.1 4.3 2.1 7.9 0.0 2.4 2 1 1 3 3 3 0 Omega-atracotoxin Glutaredoxin PF00462.19 ESA01501.1 - 2e-18 66.1 0.0 2.9e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DrrA_P4M PF14860.1 ESA01504.1 - 0.071 12.8 0.5 0.085 12.6 0.3 1.3 1 1 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain GET2 PF08690.5 ESA01505.1 - 0.13 11.4 0.1 0.14 11.4 0.1 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 HMG_box PF00505.14 ESA01506.1 - 5.2e-06 26.6 2.3 1.2e-05 25.4 1.6 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA01506.1 - 7.1e-06 26.3 1.7 1.5e-05 25.2 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain Lyase_8_N PF08124.6 ESA01506.1 - 0.071 11.9 3.6 4.9 5.9 1.0 2.6 2 1 1 3 3 3 0 Polysaccharide lyase family 8, N terminal alpha-helical domain RNA_pol_Rpb1_5 PF04998.12 ESA01506.1 - 5 6.3 7.8 8.5 5.5 5.4 1.6 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF2373 PF10180.4 ESA01509.1 - 0.0026 17.2 0.5 0.015 14.8 0.4 2.0 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) AAA_12 PF13087.1 ESA01509.1 - 0.063 12.6 0.4 0.15 11.4 0.1 1.6 1 1 1 2 2 2 0 AAA domain Adeno_E4 PF05385.6 ESA01510.1 - 0.08 12.9 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Mastadenovirus early E4 13 kDa protein RRM_1 PF00076.17 ESA01511.1 - 0.0049 16.4 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SlyX PF04102.7 ESA01511.1 - 0.55 10.6 2.3 0.55 10.6 0.1 2.2 2 0 0 2 2 2 0 SlyX DUF2217 PF10265.4 ESA01511.1 - 0.92 8.2 4.9 1.1 7.9 3.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Macoilin PF09726.4 ESA01511.1 - 2 6.6 15.0 2.7 6.1 10.4 1.1 1 0 0 1 1 1 0 Transmembrane protein MIP-T3 PF10243.4 ESA01512.1 - 0.62 8.4 12.7 0.66 8.3 8.8 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Sec3_C PF09763.4 ESA01512.1 - 1.7 6.6 8.4 2.1 6.3 5.8 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Suf PF05843.9 ESA01512.1 - 3.2 7.4 8.2 4.4 6.9 5.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hid1 PF12722.2 ESA01512.1 - 4.8 4.7 17.9 5.7 4.4 12.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DNA_pol_viral_N PF00242.12 ESA01512.1 - 6.3 5.7 19.2 8.7 5.2 13.3 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Ndc1_Nup PF09531.5 ESA01512.1 - 9.4 4.5 10.7 9.8 4.4 7.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CorA PF01544.13 ESA01513.1 - 0.014 14.4 0.1 0.021 13.8 0.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein NBP1 PF08537.5 ESA01513.1 - 0.016 14.4 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Syntaxin-6_N PF09177.6 ESA01513.1 - 0.072 13.4 0.3 0.12 12.7 0.2 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Med9 PF07544.8 ESA01513.1 - 0.099 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF1664 PF07889.7 ESA01513.1 - 0.1 12.3 0.3 0.14 11.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlxA PF14282.1 ESA01513.1 - 0.18 11.7 1.0 0.37 10.7 0.7 1.5 1 0 0 1 1 1 0 FlxA-like protein SlyX PF04102.7 ESA01513.1 - 0.24 11.8 1.5 0.32 11.3 0.1 2.0 2 1 0 2 2 2 0 SlyX Transformer PF06495.6 ESA01514.1 - 0.12 12.2 15.0 0.2 11.5 10.4 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein Syntaxin-6_N PF09177.6 ESA01514.1 - 0.41 11.0 0.1 0.41 11.0 0.0 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SlyX PF04102.7 ESA01514.1 - 1.6 9.1 3.7 2.6 8.4 0.0 3.0 4 0 0 4 4 4 0 SlyX Macoilin PF09726.4 ESA01514.1 - 1.8 6.7 12.7 3 6.0 8.8 1.4 1 0 0 1 1 1 0 Transmembrane protein MULE PF10551.4 ESA01515.1 - 0.00043 20.3 0.1 0.00078 19.5 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain tRNA-synt_1c PF00749.16 ESA01517.1 - 0.034 12.8 2.0 0.039 12.5 1.4 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF1149 PF06619.6 ESA01517.1 - 0.11 12.3 1.2 0.14 12.0 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1149) Pkinase_Tyr PF07714.12 ESA01519.1 - 0.00021 20.4 0.0 0.0003 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01519.1 - 0.0053 15.9 0.0 0.0083 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF2507 PF10702.4 ESA01519.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2507) DUF19 PF01579.13 ESA01520.1 - 0.029 14.3 3.0 0.038 13.9 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF19) Pox_E2-like PF04497.7 ESA01522.1 - 0.018 13.1 0.8 0.019 13.0 0.6 1.0 1 0 0 1 1 1 0 Poxviridae protein RHH_3 PF12651.2 ESA01522.1 - 0.054 13.2 0.5 0.087 12.5 0.3 1.4 1 1 0 1 1 1 0 Ribbon-helix-helix domain Tenui_NCP PF04876.7 ESA01522.1 - 0.059 12.9 0.0 0.059 12.9 0.0 1.0 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein DDE_1 PF03184.14 ESA01523.1 - 6.1e-05 22.2 0.8 9.4e-05 21.6 0.2 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Nucleoplasmin PF03066.10 ESA01523.1 - 0.055 12.9 0.6 0.088 12.3 0.4 1.3 1 0 0 1 1 1 0 Nucleoplasmin DDE_1 PF03184.14 ESA01524.1 - 1.7e-25 89.4 1.5 2e-25 89.2 1.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA01524.1 - 0.0097 15.6 0.1 0.015 15.0 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Leptin PF02024.10 ESA01526.1 - 0.026 14.2 0.0 0.027 14.1 0.0 1.0 1 0 0 1 1 1 0 Leptin dCMP_cyt_deam_1 PF00383.17 ESA01527.1 - 3.3e-14 52.3 0.0 4.2e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 ESA01527.1 - 1.2e-10 41.5 0.0 1e-08 35.2 0.0 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.1 ESA01527.1 - 0.14 11.5 0.2 2.5 7.4 0.0 2.0 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases DNMT1-RFD PF12047.3 ESA01528.1 - 3.8e-21 75.3 0.2 8.1e-21 74.2 0.2 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain BAH PF01426.13 ESA01528.1 - 2.3e-14 53.1 0.6 2.3e-14 53.1 0.4 2.0 2 0 0 2 2 2 1 BAH domain CUE PF02845.11 ESA01528.1 - 0.001 18.4 0.0 0.0038 16.6 0.0 2.0 1 0 0 1 1 1 1 CUE domain DUF4116 PF13475.1 ESA01528.1 - 0.046 13.2 0.2 0.82 9.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) DNA_methylase PF00145.12 ESA01529.1 - 1.6e-49 168.8 0.0 9.3e-49 166.3 0.0 2.1 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase FAM196 PF15265.1 ESA01532.1 - 0.012 14.8 5.1 0.017 14.3 3.5 1.2 1 0 0 1 1 1 0 FAM196 family Corona_nucleoca PF00937.13 ESA01532.1 - 0.057 12.3 8.8 0.082 11.8 6.1 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SlyX PF04102.7 ESA01532.1 - 0.075 13.4 0.1 0.23 11.8 0.0 1.9 2 0 0 2 2 2 0 SlyX DUF4614 PF15391.1 ESA01532.1 - 0.17 11.6 10.5 0.27 11.0 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.4 ESA01532.1 - 0.17 10.1 7.4 0.22 9.7 5.1 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF4482 PF14818.1 ESA01532.1 - 9.1 6.9 8.5 42 4.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) DUF1297 PF06973.7 ESA01533.1 - 0.023 14.0 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) DUF2036 PF09724.4 ESA01533.1 - 0.12 11.4 0.1 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2036) Pkinase_Tyr PF07714.12 ESA01534.1 - 3.1e-52 177.2 0.0 1.8e-51 174.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Sel1 PF08238.7 ESA01534.1 - 2e-50 168.0 1.6 6.2e-10 39.3 0.2 6.4 6 0 0 6 6 6 6 Sel1 repeat Pkinase PF00069.20 ESA01534.1 - 1e-47 162.4 0.2 1.8e-47 161.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA01534.1 - 0.0019 17.5 0.1 0.0036 16.6 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA01534.1 - 0.0039 16.2 0.0 0.0065 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA01534.1 - 0.013 14.4 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RFC1 PF08519.7 ESA01534.1 - 0.039 13.7 0.8 0.092 12.4 0.5 1.6 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain APH PF01636.18 ESA01534.1 - 0.17 11.6 0.0 0.44 10.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family MIT PF04212.13 ESA01534.1 - 1.5 8.7 8.7 31 4.5 0.1 4.2 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA01535.1 - 6.6e-228 732.2 106.4 1.5e-12 47.7 0.4 25.1 25 0 0 25 25 25 25 Sel1 repeat TPR_6 PF13174.1 ESA01535.1 - 2.4e-13 49.5 53.1 0.022 15.1 0.1 17.1 21 0 0 21 21 21 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA01535.1 - 0.00071 20.1 23.0 1.4 9.6 0.1 9.6 9 1 1 10 10 10 2 Tetratricopeptide repeat DUF3586 PF12131.3 ESA01535.1 - 0.0072 16.3 1.2 20 5.3 0.0 4.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3586) Guanylate_cyc_2 PF09778.4 ESA01535.1 - 5.3 6.1 15.2 0.6 9.2 0.0 4.9 4 1 0 5 5 5 0 Guanylylate cyclase Sel1 PF08238.7 ESA01536.1 - 3e-157 507.6 74.7 1.4e-10 41.4 0.1 18.5 18 0 0 18 18 18 17 Sel1 repeat TPR_6 PF13174.1 ESA01536.1 - 1.5e-09 37.6 33.3 0.42 11.1 0.1 12.2 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA01536.1 - 0.32 11.7 14.0 11 6.8 0.0 6.9 7 2 2 9 9 9 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA01538.1 - 7.1e-38 128.2 1.9 4.7e-11 42.9 0.3 4.1 4 0 0 4 4 4 4 Sel1 repeat NSF PF02071.15 ESA01538.1 - 0.21 12.2 2.2 6.9 7.7 0.1 3.4 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.12 ESA01538.1 - 6.5 6.9 11.7 46 4.2 0.0 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat HHH_3 PF12836.2 ESA01539.1 - 0.0079 16.1 0.2 0.026 14.4 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif PsbU PF06514.6 ESA01539.1 - 0.051 13.4 0.2 0.18 11.6 0.2 2.0 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pkinase_Tyr PF07714.12 ESA01540.1 - 3.4e-06 26.3 0.0 4.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01540.1 - 0.042 13.0 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Transposase_24 PF03004.9 ESA01540.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) BTB PF00651.26 ESA01541.1 - 2.4e-15 56.4 0.1 4.5e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA01541.1 - 1.1e-10 41.6 1.1 4.3e-10 39.7 0.1 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA01541.1 - 6.9e-07 29.0 3.7 1.1e-05 25.1 0.5 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF1836 PF08876.6 ESA01541.1 - 0.018 14.7 0.5 0.057 13.1 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1836) Urm1 PF09138.6 ESA01541.1 - 0.047 13.7 0.9 0.17 12.0 0.7 2.0 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) RabGAP-TBC PF00566.13 ESA01542.1 - 2.2e-39 135.1 2.6 2.2e-39 135.1 1.8 1.8 2 1 0 2 2 2 1 Rab-GTPase-TBC domain IZUMO PF15005.1 ESA01542.1 - 0.14 12.2 1.3 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 Izumo sperm-egg fusion Solute_trans_a PF03619.11 ESA01543.1 - 6.4e-103 343.8 11.6 7.8e-103 343.5 8.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha SfsA PF03749.8 ESA01544.1 - 0.0013 18.2 1.4 0.0018 17.7 1.0 1.3 1 0 0 1 1 1 1 Sugar fermentation stimulation protein N1221 PF07923.8 ESA01545.1 - 0.0054 15.6 0.2 0.006 15.4 0.2 1.0 1 0 0 1 1 1 1 N1221-like protein Bcl-2 PF00452.14 ESA01545.1 - 0.082 13.0 0.5 1.8 8.7 0.0 2.1 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family DUF368 PF04018.8 ESA01545.1 - 0.22 10.6 1.3 0.22 10.6 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF368) LRR_4 PF12799.2 ESA01546.1 - 0.69 9.5 13.5 2.1 8.0 0.1 5.5 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) Ribonuc_P_40 PF08584.6 ESA01547.1 - 7.8e-68 228.5 0.0 9.6e-68 228.2 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit EIF_2_alpha PF07541.7 ESA01548.1 - 1.3e-45 153.7 0.1 2.5e-45 152.8 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 ESA01548.1 - 6.7e-13 48.5 0.9 1.4e-12 47.5 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain WD40 PF00400.27 ESA01550.1 - 2.1e-11 43.2 0.1 4.6 7.2 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Prot_inhib_II PF02428.10 ESA01550.1 - 2.2 8.4 4.4 3.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Potato type II proteinase inhibitor family DUF4363 PF14276.1 ESA01551.1 - 0.98 9.1 4.7 2.2 7.9 0.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) zf-RING_4 PF14570.1 ESA01554.1 - 4.3 6.9 11.1 0.12 11.9 1.5 2.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain NOB1_Zn_bind PF08772.6 ESA01554.1 - 4.6 7.1 5.9 0.5 10.2 0.4 2.0 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-MYND PF01753.13 ESA01554.1 - 6.7 6.6 8.4 4.3 7.2 0.2 2.4 2 0 0 2 2 2 0 MYND finger FYVE_2 PF02318.11 ESA01554.1 - 8.6 6.2 7.6 1.2 9.0 2.1 1.8 1 1 1 2 2 2 0 FYVE-type zinc finger TLD PF07534.11 ESA01556.1 - 4.3e-09 36.4 1.1 1.1e-08 35.1 0.8 1.8 1 0 0 1 1 1 1 TLD Herpes_Helicase PF02689.9 ESA01559.1 - 1.7e-06 26.1 0.0 1.7e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA01559.1 - 0.00038 20.5 0.0 0.0007 19.7 0.0 1.5 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain zf-C4pol PF14260.1 ESA01560.1 - 0.027 14.4 3.3 0.064 13.2 2.3 1.6 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Auto_anti-p27 PF06677.7 ESA01560.1 - 0.049 13.4 2.7 0.18 11.5 0.1 2.3 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-3CxxC PF13695.1 ESA01560.1 - 0.098 12.8 3.3 0.16 12.2 2.3 1.4 1 1 0 1 1 1 0 Zinc-binding domain RNA_POL_M_15KD PF02150.11 ESA01560.1 - 0.29 10.8 2.9 0.52 10.0 2.0 1.4 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit DUF4428 PF14471.1 ESA01560.1 - 0.59 9.9 7.0 0.2 11.4 2.8 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) HypA PF01155.14 ESA01560.1 - 1 9.0 5.9 1.7 8.3 2.0 2.1 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF257 PF03192.8 ESA01566.1 - 0.036 13.3 0.3 0.036 13.3 0.2 3.3 4 0 0 4 4 4 0 Pyrococcus protein of unknown function, DUF257 RNA_bind_2 PF10133.4 ESA01566.1 - 0.06 13.3 0.4 9.2 6.3 0.0 3.5 4 0 0 4 4 4 0 Predicted RNA-binding protein Spt5-NGN PF03439.8 ESA01566.1 - 0.29 10.8 2.3 1.6 8.5 0.1 3.0 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section DASH_Dam1 PF08653.5 ESA01567.1 - 4.8e-16 58.2 0.6 8.6e-16 57.4 0.1 1.7 2 0 0 2 2 2 1 DASH complex subunit Dam1 TrmB PF01978.14 ESA01567.1 - 0.0056 16.3 0.4 0.036 13.7 0.0 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB UBN2 PF14223.1 ESA01567.1 - 0.18 11.5 0.8 3.8 7.3 0.0 2.5 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type Pyrophosphatase PF00719.14 ESA01568.1 - 2.9e-53 179.5 0.2 3.9e-53 179.0 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Bac_small_YrzI PF09501.5 ESA01568.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) Carn_acyltransf PF00755.15 ESA01569.1 - 9.9e-89 298.0 0.0 1.2e-88 297.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase LRR_8 PF13855.1 ESA01572.1 - 0.081 12.6 0.1 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 Leucine rich repeat DUF3870 PF12986.2 ESA01573.1 - 0.075 13.2 0.4 0.16 12.2 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) IL7 PF01415.11 ESA01573.1 - 0.22 11.1 2.6 0.11 12.1 0.4 1.5 2 0 0 2 2 2 0 Interleukin 7/9 family SAD_SRA PF02182.12 ESA01576.1 - 0.024 13.9 0.1 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 SAD/SRA domain DASH_Duo1 PF08651.5 ESA01576.1 - 0.038 13.5 0.0 0.084 12.4 0.0 1.6 1 1 1 2 2 2 0 DASH complex subunit Duo1 DUF1672 PF07901.6 ESA01576.1 - 0.2 10.5 2.5 0.25 10.2 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) F-box-like PF12937.2 ESA01577.1 - 0.005 16.5 1.7 0.015 15.0 1.1 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA01577.1 - 0.051 13.2 16.2 2.1 8.0 0.0 6.0 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) F-box PF00646.28 ESA01577.1 - 3.1 7.5 8.1 1.3 8.7 0.9 3.5 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.2 ESA01578.1 - 1e-05 25.1 1.4 3.2e-05 23.5 1.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA01578.1 - 0.83 9.3 6.7 0.5 10.1 0.5 3.3 3 0 0 3 3 3 0 F-box domain ATG16 PF08614.6 ESA01579.1 - 6.9e-06 26.0 6.8 6.9e-06 26.0 4.7 2.9 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.4 ESA01579.1 - 0.011 15.8 6.8 0.011 15.8 4.7 2.6 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HalX PF08663.5 ESA01579.1 - 0.021 14.8 2.3 0.021 14.8 1.6 2.3 2 2 0 2 2 2 0 HalX domain Mod_r PF07200.8 ESA01579.1 - 0.023 14.6 6.2 0.023 14.6 4.3 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF1202 PF06717.6 ESA01579.1 - 0.039 13.2 5.0 0.04 13.2 0.3 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1202) Spectrin PF00435.16 ESA01579.1 - 0.049 13.9 10.5 0.028 14.6 5.6 2.0 1 1 1 2 2 2 0 Spectrin repeat DivIVA PF05103.8 ESA01579.1 - 0.27 11.2 19.0 0.28 11.2 3.3 3.0 1 1 1 2 2 2 0 DivIVA protein WD40_alt PF14077.1 ESA01579.1 - 0.28 10.8 5.0 7.2 6.3 0.4 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF641 PF04859.7 ESA01579.1 - 0.48 10.1 10.4 0.033 13.9 2.1 2.2 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF972 PF06156.8 ESA01579.1 - 0.59 10.4 19.9 3.4 8.0 1.7 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Atg14 PF10186.4 ESA01579.1 - 0.92 8.3 17.5 2.8 6.8 11.9 1.7 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 ESA01579.1 - 1.6 8.5 20.6 0.12 12.2 5.2 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.3 ESA01579.1 - 1.7 7.8 11.4 5.3 6.2 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlaC_arch PF05377.6 ESA01579.1 - 1.9 8.4 6.8 1.5 8.7 2.3 2.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF3735 PF12537.3 ESA01579.1 - 2.1 8.4 4.6 3.9 7.5 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3735) DUF745 PF05335.8 ESA01579.1 - 2.6 7.5 10.9 2.3 7.7 5.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DivIC PF04977.10 ESA01579.1 - 2.8 7.5 14.3 0.2 11.1 3.3 3.0 1 1 2 3 3 3 0 Septum formation initiator TMPIT PF07851.8 ESA01579.1 - 2.9 6.8 9.7 7.1 5.5 6.5 1.7 1 1 0 1 1 1 0 TMPIT-like protein DUF572 PF04502.8 ESA01579.1 - 4.4 6.4 11.2 5.3 6.1 7.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) IncA PF04156.9 ESA01579.1 - 6.8 6.2 27.4 1e+02 2.4 0.8 2.0 1 1 1 2 2 2 0 IncA protein TMPIT PF07851.8 ESA01580.1 - 0.0053 15.8 3.5 0.0086 15.1 2.5 1.2 1 0 0 1 1 1 1 TMPIT-like protein DUF4407 PF14362.1 ESA01580.1 - 0.013 14.4 0.8 0.019 13.9 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.6 ESA01580.1 - 0.014 14.7 2.5 0.014 14.7 1.7 1.5 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HrpB7 PF09486.5 ESA01580.1 - 0.014 15.2 0.5 0.019 14.8 0.3 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) ECM11 PF15463.1 ESA01580.1 - 0.027 14.7 1.3 0.059 13.6 0.9 1.5 1 0 0 1 1 1 0 Extracellular mutant protein 11 TPR_MLP1_2 PF07926.7 ESA01580.1 - 0.04 13.6 10.8 0.59 9.8 7.5 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.6 ESA01580.1 - 0.046 13.6 3.0 0.079 12.8 1.5 1.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF4591 PF15261.1 ESA01580.1 - 0.056 13.6 0.5 0.13 12.5 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4591) DUF745 PF05335.8 ESA01580.1 - 0.079 12.4 3.4 0.11 11.9 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Cortex-I_coil PF09304.5 ESA01580.1 - 0.081 12.9 7.8 0.11 12.5 4.5 1.9 1 1 1 2 2 2 0 Cortexillin I, coiled coil E2R135 PF11570.3 ESA01580.1 - 0.095 12.7 1.8 0.12 12.4 1.2 1.2 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 ATG16 PF08614.6 ESA01580.1 - 0.19 11.5 9.7 0.17 11.6 5.7 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF641 PF04859.7 ESA01580.1 - 0.2 11.4 4.9 0.26 11.0 1.3 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Bap31 PF05529.7 ESA01580.1 - 0.22 10.9 4.9 0.75 9.2 1.1 2.4 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Atg14 PF10186.4 ESA01580.1 - 0.41 9.5 5.6 0.56 9.1 3.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3899 PF13038.1 ESA01580.1 - 0.55 10.4 3.7 1.1 9.5 0.0 2.4 2 1 1 3 3 2 0 Domain of unknown function (DUF3899) DivIC PF04977.10 ESA01580.1 - 1.2 8.7 9.7 0.036 13.5 1.9 2.2 2 1 0 2 2 2 0 Septum formation initiator DUF972 PF06156.8 ESA01580.1 - 1.6 9.1 10.3 6.6 7.1 3.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Granulin PF00396.13 ESA01583.1 - 0.00033 20.6 24.6 0.011 15.7 5.7 2.2 1 1 1 2 2 2 2 Granulin DUF2648 PF10855.3 ESA01583.1 - 0.28 10.6 3.1 0.52 9.7 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) COP23 PF14218.1 ESA01585.1 - 0.036 13.6 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Pkinase PF00069.20 ESA01586.1 - 1.4e-47 162.0 0.1 1.8e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01586.1 - 1.3e-44 152.2 0.0 1.7e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA01586.1 - 0.00015 21.5 0.1 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA01586.1 - 0.0011 18.1 0.2 0.0017 17.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA01586.1 - 0.0014 17.8 0.0 0.0024 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA01586.1 - 0.0027 17.0 0.1 0.014 14.7 0.0 2.1 2 1 1 3 3 3 1 RIO1 family DUF4286 PF14114.1 ESA01586.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) DUF4127 PF13552.1 ESA01587.1 - 0.0095 14.3 0.0 0.01 14.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4127) Pkinase PF00069.20 ESA01588.1 - 5.4e-15 55.2 0.7 1.2e-14 54.1 0.5 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01588.1 - 0.00042 19.4 0.1 0.00084 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Trypan_PARP PF05887.6 ESA01589.1 - 0.11 12.2 8.6 0.15 11.8 6.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MreB_Mbl PF06723.8 ESA01590.1 - 0.095 11.2 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein Kelch_6 PF13964.1 ESA01592.1 - 9e-18 63.6 9.7 2.9e-05 24.0 0.2 4.9 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA01592.1 - 1.1e-17 63.2 6.8 3.5e-06 26.4 0.2 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.1 ESA01592.1 - 6.6e-17 61.0 9.9 9.1e-05 22.3 0.0 5.3 5 1 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA01592.1 - 1.5e-14 53.7 0.1 0.0009 19.3 0.0 4.5 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA01592.1 - 5.6e-14 51.6 6.5 0.0066 16.2 0.1 5.3 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01592.1 - 7e-12 44.6 7.0 9.1e-05 22.0 0.0 5.5 5 1 0 5 5 5 3 Kelch motif Herpes_gE PF02480.11 ESA01592.1 - 0.19 9.9 0.0 0.26 9.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E GLE1 PF07817.8 ESA01593.1 - 0.00031 19.7 0.0 0.00046 19.1 0.0 1.2 1 0 0 1 1 1 1 GLE1-like protein Ino80_Iec3 PF14612.1 ESA01594.1 - 0.84 9.6 11.5 1.5 8.8 8.0 1.3 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling IncA PF04156.9 ESA01594.1 - 9.9 5.7 16.5 1.5 8.3 8.2 1.8 2 0 0 2 2 2 0 IncA protein Pkinase PF00069.20 ESA01595.1 - 1.2e-44 152.4 0.1 1.8e-44 151.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01595.1 - 4.7e-43 147.1 0.0 6.4e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA01595.1 - 0.00052 19.3 4.0 0.00085 18.6 2.0 1.9 1 1 1 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA01595.1 - 0.00096 18.2 0.6 0.0017 17.4 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA01595.1 - 0.015 14.6 0.2 0.033 13.5 0.1 1.7 1 1 0 1 1 1 0 RIO1 family APH PF01636.18 ESA01595.1 - 0.019 14.7 0.3 0.028 14.1 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.26 ESA01597.1 - 4e-12 46.1 2.0 1.2e-10 41.3 0.2 3.2 2 1 0 2 2 2 1 BTB/POZ domain HATPase_c_3 PF13589.1 ESA01597.1 - 0.013 15.1 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Bax1-I PF01027.15 ESA01598.1 - 4.4e-31 108.1 25.6 5.2e-31 107.8 17.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Claudin_2 PF13903.1 ESA01598.1 - 8.7 5.9 12.7 1.3 8.7 3.4 2.3 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction FtsJ PF01728.14 ESA01599.1 - 5.5e-58 195.9 0.0 6.6e-58 195.6 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 ESA01599.1 - 0.055 13.0 0.2 0.25 10.9 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain 2OG-FeII_Oxy PF03171.15 ESA01600.1 - 2.8e-20 72.4 0.0 4.3e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 ESA01600.1 - 9.8e-19 68.0 0.0 2e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ribosomal_L12 PF00542.14 ESA01601.1 - 0.11 12.5 0.4 0.12 12.4 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Tox-REase-7 PF15649.1 ESA01601.1 - 0.13 12.4 2.8 0.13 12.4 1.9 1.1 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 Laminin_II PF06009.7 ESA01601.1 - 0.18 11.5 2.7 0.19 11.5 1.9 1.1 1 0 0 1 1 1 0 Laminin Domain II HSBP1 PF06825.7 ESA01601.1 - 1.4 8.5 5.0 16 5.1 3.5 2.1 1 1 0 1 1 1 0 Heat shock factor binding protein 1 p450 PF00067.17 ESA01602.1 - 7.2e-43 146.7 0.1 7.9e-43 146.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DDE_1 PF03184.14 ESA01603.1 - 3.5e-40 137.4 1.2 8.9e-40 136.1 0.9 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease PIF1 PF05970.9 ESA01604.1 - 0.00012 21.1 0.0 0.0019 17.1 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase Sigma54_activ_2 PF14532.1 ESA01605.1 - 0.0023 17.9 0.1 0.7 9.9 0.0 2.2 2 0 0 2 2 2 2 Sigma-54 interaction domain Amidohydro_1 PF01979.15 ESA01606.1 - 1.1e-19 71.3 0.1 1.4e-19 70.9 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family A_deaminase PF00962.17 ESA01606.1 - 0.00015 20.8 0.0 0.00019 20.4 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_3 PF07969.6 ESA01606.1 - 0.059 12.5 0.0 0.08 12.1 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family DDE_3 PF13358.1 ESA01608.1 - 0.0021 17.7 0.0 0.013 15.2 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease AAA_13 PF13166.1 ESA01609.1 - 3.3e-05 22.5 10.7 4e-05 22.3 7.4 1.0 1 0 0 1 1 1 1 AAA domain UPF0118 PF01594.11 ESA01609.1 - 0.00012 21.2 0.6 0.00012 21.2 0.4 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF20 Atg14 PF10186.4 ESA01609.1 - 0.024 13.5 19.9 0.035 13.0 13.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CENP-F_leu_zip PF10473.4 ESA01609.1 - 0.055 13.3 19.1 0.092 12.5 13.2 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.3 ESA01609.1 - 0.29 8.4 21.0 0.35 8.1 14.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3135 PF11333.3 ESA01609.1 - 0.61 10.2 9.5 0.73 10.0 6.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) DUF87 PF01935.12 ESA01609.1 - 0.62 9.8 6.7 0.9 9.3 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 CcmD PF04995.9 ESA01609.1 - 0.85 9.4 6.3 3.7 7.3 4.0 2.5 1 1 1 2 2 2 0 Heme exporter protein D (CcmD) MitMem_reg PF13012.1 ESA01609.1 - 0.86 9.7 11.0 0.48 10.5 5.5 1.8 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function DUF342 PF03961.8 ESA01609.1 - 0.88 7.9 15.2 1.2 7.5 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GNT-I PF03071.10 ESA01609.1 - 1.2 7.6 6.9 1.4 7.3 4.8 1.2 1 0 0 1 1 1 0 GNT-I family DUF4094 PF13334.1 ESA01609.1 - 1.6 9.1 10.9 0.31 11.4 2.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF2390 PF09523.5 ESA01609.1 - 2.2 8.4 10.4 0.38 10.9 4.8 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF2390) Pox_A_type_inc PF04508.7 ESA01609.1 - 4.1 7.4 15.1 0.16 11.8 1.4 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Pepsin-I3 PF06394.8 ESA01609.1 - 4.4 7.0 17.5 0.066 12.8 2.6 2.8 1 1 2 3 3 3 0 Pepsin inhibitor-3-like repeated domain Peptidase_S49_N PF08496.5 ESA01609.1 - 6.9 6.4 15.2 61 3.3 10.5 2.1 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Allexi_40kDa PF05549.6 ESA01609.1 - 8.2 5.6 10.0 11 5.1 7.0 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein HemX PF04375.9 ESA01609.1 - 8.5 4.8 17.6 83 1.5 12.2 1.9 1 1 0 1 1 1 0 HemX Put_Phosphatase PF06888.7 ESA01610.1 - 3.3e-52 176.9 0.2 3.8e-52 176.8 0.1 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.2 ESA01610.1 - 3.3e-07 30.6 0.1 6e-07 29.8 0.1 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA01610.1 - 3.3e-05 24.1 0.1 0.00062 20.0 0.1 2.6 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Cir_N PF10197.4 ESA01610.1 - 0.019 14.9 0.3 0.037 14.0 0.2 1.4 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR RNase_PH PF01138.16 ESA01611.1 - 8.1e-24 84.4 0.0 1.5e-23 83.5 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESA01611.1 - 6.3e-15 54.8 0.0 1.2e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Nol1_Nop2_Fmu PF01189.12 ESA01612.1 - 1.6e-24 86.8 0.0 2.8e-14 53.1 0.0 2.1 2 0 0 2 2 2 2 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 ESA01612.1 - 2.1e-10 40.3 0.4 1.1e-07 31.5 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA01612.1 - 3.2e-06 27.6 0.0 3.5e-05 24.3 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA01612.1 - 0.00019 21.7 0.0 0.00048 20.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA01612.1 - 0.00083 19.3 0.0 0.0024 17.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA01612.1 - 0.0086 16.5 0.0 0.26 11.8 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA01612.1 - 0.019 14.6 0.0 2 8.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 ESA01612.1 - 0.047 12.7 0.0 0.11 11.6 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 ESA01612.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase L51_S25_CI-B8 PF05047.11 ESA01613.1 - 2.8e-07 30.1 0.1 6.2e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain AAA PF00004.24 ESA01614.1 - 1.1e-15 58.0 0.2 2.3e-15 56.9 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 ESA01614.1 - 4e-11 42.7 0.1 9.2e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESA01614.1 - 8.8e-09 35.2 0.1 6.4e-07 29.1 0.1 2.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 ESA01614.1 - 6.5e-08 32.5 0.2 2.1e-07 30.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA01614.1 - 6.8e-07 28.9 0.0 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain Rad17 PF03215.10 ESA01614.1 - 5.6e-06 25.3 0.1 0.0036 16.0 0.0 2.4 1 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 ESA01614.1 - 6.4e-06 26.2 0.1 8.3e-05 22.6 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.1 ESA01614.1 - 3.6e-05 23.4 0.1 6.6e-05 22.5 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA01614.1 - 6.2e-05 23.1 0.1 0.011 15.8 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 ESA01614.1 - 0.00043 19.3 0.0 0.0011 18.0 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESA01614.1 - 0.0011 17.9 0.0 0.0024 16.8 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 ESA01614.1 - 0.0018 17.4 0.0 0.0042 16.2 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 ESA01614.1 - 0.0064 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.6 ESA01614.1 - 0.0068 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.24 ESA01614.1 - 0.0084 15.6 0.3 0.39 10.2 0.0 2.7 1 1 1 3 3 3 1 DEAD/DEAH box helicase Arch_ATPase PF01637.13 ESA01614.1 - 0.022 14.4 0.1 0.074 12.7 0.1 1.9 1 1 0 1 1 1 0 Archaeal ATPase DNA_pol3_delta PF06144.8 ESA01614.1 - 0.034 13.6 0.2 0.073 12.5 0.2 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_5 PF07728.9 ESA01614.1 - 0.046 13.4 0.1 0.17 11.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESA01614.1 - 0.048 13.9 0.1 0.16 12.2 0.0 2.0 2 1 0 2 2 1 0 AAA domain DNA_pol3_gamma3 PF12169.3 ESA01614.1 - 0.11 12.2 0.2 2 8.1 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III AAA_28 PF13521.1 ESA01614.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESA01614.1 - 0.14 11.5 1.1 5.5 6.3 0.1 2.3 1 1 1 2 2 2 0 AAA-like domain ORC5_C PF14630.1 ESA01616.1 - 0.0082 15.6 0.8 0.063 12.7 0.1 2.0 1 1 1 2 2 2 1 Origin recognition complex (ORC) subunit 5 C-terminus PrkA PF06798.7 ESA01616.1 - 0.069 12.4 0.1 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain zf-RING_2 PF13639.1 ESA01618.1 - 7.1e-08 32.1 3.8 1.1e-07 31.5 2.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA01618.1 - 0.00029 20.8 4.3 0.0005 20.0 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA01618.1 - 0.00051 20.0 0.6 0.0009 19.3 0.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA01618.1 - 0.00069 19.2 2.4 0.0015 18.0 1.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA01618.1 - 0.00094 18.8 3.4 0.0018 17.9 2.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA01618.1 - 0.0018 17.9 1.2 0.003 17.2 0.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA01618.1 - 0.0019 17.9 0.2 0.0041 16.9 0.1 1.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.17 ESA01618.1 - 0.036 13.7 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.6 ESA01618.1 - 0.037 14.0 1.6 0.068 13.1 1.1 1.5 1 0 0 1 1 1 0 RING-like domain TFIIE_alpha PF02002.12 ESA01618.1 - 0.11 11.9 0.1 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 TFIIE alpha subunit PQ-loop PF04193.9 ESA01619.1 - 1.2e-11 44.0 6.3 9.8e-08 31.4 0.0 3.3 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.13 ESA01619.1 - 0.08 13.4 3.6 0.17 12.3 2.5 1.6 1 1 0 1 1 1 0 ER lumen protein retaining receptor Sterol-sensing PF12349.3 ESA01620.1 - 7.9e-41 139.0 9.2 2e-40 137.7 6.4 1.7 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 ESA01620.1 - 2e-20 72.3 0.5 3.4e-20 71.5 0.4 1.3 1 0 0 1 1 1 1 Patched family WD40 PF00400.27 ESA01620.1 - 2.5e-06 27.1 7.4 4.1 7.4 0.0 6.0 5 0 0 5 5 5 4 WD domain, G-beta repeat Bromodomain PF00439.20 ESA01621.1 - 9.3e-20 70.3 1.1 3e-19 68.6 0.8 1.9 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.8 ESA01621.1 - 3.5e-10 39.4 0.0 1.3e-09 37.6 0.0 2.0 1 0 0 1 1 1 1 Bromodomain associated Asp-B-Hydro_N PF05279.6 ESA01621.1 - 0.96 9.2 32.4 1.4 8.7 13.8 2.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region ERM PF00769.14 ESA01621.1 - 2.2 7.7 48.6 0.11 11.9 24.0 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family KH_1 PF00013.24 ESA01622.1 - 9.6e-107 348.6 65.7 1.5e-14 53.3 1.0 14.5 14 1 0 14 14 14 13 KH domain KH_3 PF13014.1 ESA01622.1 - 2.7e-75 247.0 41.5 6.1e-10 38.5 1.7 14.8 14 0 0 14 14 14 13 KH domain KH_2 PF07650.12 ESA01622.1 - 1.4e-10 40.5 40.7 0.34 10.4 0.1 11.8 10 1 1 11 11 11 7 KH domain SLS PF14611.1 ESA01622.1 - 7.2e-08 32.1 27.2 0.0057 16.0 0.5 8.9 5 2 3 9 9 9 4 Mitochondrial inner-membrane-bound regulator FliG_C PF01706.11 ESA01622.1 - 0.33 10.9 6.4 6 6.8 0.1 4.2 4 0 0 4 4 4 0 FliG C-terminal domain G-patch PF01585.18 ESA01623.1 - 1.4e-13 50.3 0.2 3.6e-13 49.0 0.1 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA01623.1 - 0.00065 19.4 0.0 0.0028 17.4 0.0 2.1 1 0 0 1 1 1 1 DExH-box splicing factor binding site C1_4 PF07975.7 ESA01623.1 - 0.13 12.3 0.2 0.32 11.0 0.1 1.6 1 0 0 1 1 1 0 TFIIH C1-like domain S1FA PF04689.8 ESA01623.1 - 0.48 10.3 3.8 0.21 11.4 0.4 2.0 2 0 0 2 2 2 0 DNA binding protein S1FA Alb1 PF09135.6 ESA01623.1 - 1.5 9.4 8.4 0.38 11.3 1.5 2.3 2 0 0 2 2 2 0 Alb1 ParA PF10609.4 ESA01624.1 - 1.9e-38 130.1 0.1 3.3e-38 129.4 0.1 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESA01624.1 - 3.7e-20 72.1 0.0 5.4e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 ESA01624.1 - 6e-08 32.0 0.0 2.2e-07 30.2 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.1 ESA01624.1 - 1.1e-07 31.9 0.0 2.1e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.10 ESA01624.1 - 7.4e-06 25.2 2.1 7.2e-05 21.9 0.6 2.5 1 1 2 3 3 3 1 Anion-transporting ATPase ArgK PF03308.11 ESA01624.1 - 3e-05 22.9 0.4 7e-05 21.7 0.2 1.6 2 0 0 2 2 2 1 ArgK protein AAA_26 PF13500.1 ESA01624.1 - 0.00027 20.5 0.1 0.38 10.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain YhjQ PF06564.7 ESA01624.1 - 0.0028 17.0 0.1 0.0043 16.4 0.0 1.4 1 1 0 1 1 1 1 YhjQ protein AAA_25 PF13481.1 ESA01624.1 - 0.0031 16.9 0.1 0.0059 16.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESA01624.1 - 0.0098 15.0 0.3 0.022 13.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 APS_kinase PF01583.15 ESA01624.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase SIS_2 PF13580.1 ESA01624.1 - 0.016 14.9 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 SIS domain Fer4_NifH PF00142.13 ESA01624.1 - 0.021 13.9 0.1 0.047 12.8 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 ESA01624.1 - 0.022 14.2 0.1 0.093 12.1 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_10 PF12846.2 ESA01624.1 - 0.081 12.3 0.2 0.18 11.2 0.1 1.5 2 0 0 2 2 2 0 AAA-like domain MobB PF03205.9 ESA01624.1 - 0.099 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 ESA01624.1 - 0.12 11.8 0.1 0.3 10.4 0.1 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF814 PF05670.8 ESA01625.1 - 2e-20 72.4 0.0 4.9e-20 71.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF814) FDF PF09532.5 ESA01625.1 - 0.29 11.7 6.4 0.55 10.7 4.3 1.7 1 1 0 1 1 1 0 FDF domain Hat1_N PF10394.4 ESA01626.1 - 6.6e-37 127.0 6.6 6.6e-37 127.0 4.6 2.0 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_7 PF13508.1 ESA01626.1 - 0.025 14.7 0.0 0.063 13.4 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA01626.1 - 0.055 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF1292 PF06949.6 ESA01626.1 - 0.078 13.3 2.6 0.17 12.2 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1292) Acetyltransf_3 PF13302.1 ESA01626.1 - 0.098 12.8 0.3 12 6.0 0.0 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Peripla_BP_2 PF01497.13 ESA01627.1 - 0.023 13.8 0.0 0.032 13.3 0.0 1.3 1 1 0 1 1 1 0 Periplasmic binding protein Myotub-related PF06602.9 ESA01628.1 - 1.4e-92 310.2 0.1 1.8e-82 276.9 0.0 2.5 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 ESA01628.1 - 0.012 15.9 0.0 0.047 13.9 0.0 2.0 1 0 0 1 1 1 0 Tyrosine phosphatase family E1-E2_ATPase PF00122.15 ESA01630.1 - 1.4e-57 194.4 6.9 1.4e-57 194.4 4.8 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA01630.1 - 6e-44 149.7 7.7 6e-44 149.7 5.3 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA01630.1 - 6.5e-29 101.8 0.0 1.3e-27 97.5 0.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA01630.1 - 4.5e-18 64.9 0.0 8.6e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESA01630.1 - 9.1e-17 61.8 0.0 3e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA01630.1 - 1.1e-09 37.6 0.0 2.6e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESA01630.1 - 9e-06 25.4 2.5 1.8e-05 24.4 0.9 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase DAGK_cat PF00781.19 ESA01630.1 - 0.051 13.0 0.4 0.54 9.6 0.0 2.6 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain CHZ PF09649.5 ESA01632.1 - 8.2e-05 21.7 0.0 0.00034 19.7 0.0 2.1 1 0 0 1 1 1 1 Histone chaperone domain CHZ G6PD_N PF00479.17 ESA01633.1 - 0.15 12.2 1.5 0.21 11.7 1.0 1.3 1 1 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain Pex14_N PF04695.8 ESA01633.1 - 0.7 9.9 6.1 0.94 9.5 4.2 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CTP_transf_2 PF01467.21 ESA01634.1 - 1.3e-12 48.0 0.0 1.5e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase zf-C2H2_2 PF12756.2 ESA01635.1 - 9.1e-34 115.5 2.3 9.1e-34 115.5 1.6 1.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Albumin_I PF08027.6 ESA01635.1 - 0.06 13.0 0.2 0.096 12.4 0.1 1.2 1 0 0 1 1 1 0 Albumin I zf-C2H2_4 PF13894.1 ESA01635.1 - 0.28 11.6 10.7 0.97 9.9 0.0 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA01635.1 - 0.81 10.1 15.9 0.51 10.7 0.2 3.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type Pkinase PF00069.20 ESA01636.1 - 3.2e-13 49.4 3.4 3.2e-13 49.4 2.3 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01636.1 - 2.9e-11 42.9 0.0 1.4e-10 40.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DUF970 PF06153.6 ESA01636.1 - 0.095 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF970) Pkinase_Tyr PF07714.12 ESA01637.1 - 3.2e-31 108.3 0.0 4.9e-31 107.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01637.1 - 1.3e-29 103.1 0.1 1.5e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Herpes_IE1 PF07340.6 ESA01637.1 - 0.093 11.1 0.0 0.098 11.0 0.0 1.0 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein APH PF01636.18 ESA01637.1 - 0.16 11.7 0.2 0.27 10.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tyrosinase PF00264.15 ESA01639.1 - 3.2e-06 27.4 0.0 5.5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Pkinase PF00069.20 ESA01640.1 - 6.8e-14 51.6 0.5 3e-10 39.6 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01640.1 - 3e-08 33.0 0.0 0.00011 21.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA01640.1 - 0.028 14.1 0.6 0.041 13.5 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF605 PF04652.11 ESA01641.1 - 2.2 7.5 8.2 2.7 7.3 5.7 1.0 1 0 0 1 1 1 0 Vta1 like GTP_EFTU PF00009.22 ESA01642.1 - 9.7e-41 139.2 1.5 9.7e-41 139.2 1.0 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 ESA01642.1 - 9.4e-32 109.1 4.9 3.4e-31 107.3 3.4 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 ESA01642.1 - 1.2e-11 44.5 0.2 1.6e-05 24.9 0.1 2.9 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA01642.1 - 2.1e-08 34.1 0.0 8.7e-08 32.1 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA01642.1 - 6.1e-07 28.8 0.1 1.7e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B IF2_N PF04760.10 ESA01642.1 - 4e-06 26.3 0.1 1.6e-05 24.4 0.1 2.2 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region Miro PF08477.8 ESA01642.1 - 7.7e-06 26.3 0.0 2.9e-05 24.5 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA01642.1 - 1.7e-05 24.1 0.0 7.1e-05 22.1 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family PduV-EutP PF10662.4 ESA01642.1 - 0.00074 19.0 0.1 0.0027 17.2 0.1 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 ESA01642.1 - 0.0028 16.4 5.1 0.026 13.3 0.2 3.3 3 0 0 3 3 3 1 ArgK protein SRPRB PF09439.5 ESA01642.1 - 0.013 14.7 0.1 0.013 14.7 0.1 3.0 3 1 0 3 3 3 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 ESA01642.1 - 0.07 12.9 6.1 5.7 6.7 0.1 4.3 3 1 1 4 4 4 0 Dynamin family SIS_2 PF13580.1 ESA01642.1 - 0.11 12.2 1.4 6.6 6.4 0.1 3.5 3 1 0 3 3 3 0 SIS domain Dynein_light PF01221.13 ESA01643.1 - 2.3e-44 149.2 0.7 2.5e-44 149.1 0.5 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ground-like PF04155.13 ESA01643.1 - 0.04 14.2 0.1 0.044 14.0 0.1 1.2 1 0 0 1 1 1 0 Ground-like domain Methyltransf_16 PF10294.4 ESA01644.1 - 2.2e-29 102.0 0.3 4.7e-29 101.0 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase BTB PF00651.26 ESA01644.1 - 0.015 15.2 0.1 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Methyltransf_18 PF12847.2 ESA01644.1 - 0.016 15.7 0.0 0.036 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESA01644.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF3650 PF12368.3 ESA01644.1 - 0.26 10.8 4.2 0.13 11.7 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3650) Ank PF00023.25 ESA01645.1 - 2.5e-22 77.5 0.1 2e-10 39.9 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 ESA01645.1 - 4.5e-17 62.1 0.0 5e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA01645.1 - 5.2e-15 54.0 0.0 2.1e-06 27.4 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 ESA01645.1 - 1e-12 48.1 0.0 8.8e-10 38.8 0.0 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA01645.1 - 1.2e-11 44.4 0.1 1.9e-05 24.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ubiquitin PF00240.18 ESA01646.1 - 0.011 15.0 0.7 0.14 11.6 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin family Peptidase_C11 PF03415.9 ESA01648.1 - 0.017 14.1 0.4 0.019 13.9 0.3 1.0 1 0 0 1 1 1 0 Clostripain family RE_BstXI PF09552.5 ESA01649.1 - 0.031 13.3 0.0 0.038 13.0 0.0 1.1 1 0 0 1 1 1 0 BstXI restriction endonuclease F-box-like PF12937.2 ESA01650.1 - 7.8e-05 22.3 0.5 0.032 13.9 0.0 3.1 3 0 0 3 3 3 2 F-box-like Pkinase_Tyr PF07714.12 ESA01652.1 - 1.3e-42 145.7 0.2 2.8e-37 128.1 0.0 5.7 5 0 0 5 5 5 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01652.1 - 3.5e-37 127.9 0.1 2.3e-36 125.2 0.1 2.6 1 0 0 1 1 1 1 Protein kinase domain HSBP1 PF06825.7 ESA01652.1 - 0.15 11.6 8.8 3.2 7.4 0.0 4.6 5 0 0 5 5 5 0 Heat shock factor binding protein 1 CENP-F_leu_zip PF10473.4 ESA01652.1 - 2.5 7.9 6.4 21 4.9 0.1 3.7 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pkinase PF00069.20 ESA01653.1 - 6.5e-48 163.1 0.4 1.2e-47 162.2 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA01653.1 - 9.1e-48 159.6 9.6 2.5e-11 43.8 0.2 6.5 6 0 0 6 6 6 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA01653.1 - 9.9e-48 162.4 0.0 1.6e-47 161.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA01653.1 - 0.00055 19.3 0.5 0.0022 17.3 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA01653.1 - 0.005 15.9 0.1 0.0095 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA01653.1 - 0.08 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1053 PF06327.9 ESA01653.1 - 0.27 11.5 7.8 2.3 8.6 0.1 2.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1053) Sel1 PF08238.7 ESA01655.1 - 6.2e-62 204.6 41.7 1.2e-12 48.0 1.4 6.4 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.1 ESA01655.1 - 5.2e-05 23.4 12.4 0.51 10.9 0.1 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA01655.1 - 0.00023 20.7 32.2 0.059 13.0 3.9 5.9 1 1 6 7 7 7 5 TPR repeat TPR_16 PF13432.1 ESA01655.1 - 0.00076 20.0 0.3 2.8 8.7 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.13 ESA01655.1 - 0.00089 19.0 13.7 0.48 10.3 0.0 5.9 5 1 1 6 6 6 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA01655.1 - 0.1 12.5 21.5 4.2 7.3 1.4 5.9 1 1 4 5 5 5 0 Tetratricopeptide repeat p450 PF00067.17 ESA01656.1 - 1.5e-54 185.3 0.3 1.9e-54 184.9 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_Tyr PF07714.12 ESA01660.1 - 3.7e-06 26.2 0.0 6.9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Trans_reg_C PF00486.23 ESA01660.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal UPF0231 PF06062.6 ESA01661.1 - 0.078 12.8 0.0 0.12 12.2 0.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0231) F-box-like PF12937.2 ESA01662.1 - 8.3e-05 22.2 0.1 0.0002 21.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA01662.1 - 0.017 14.7 0.5 0.11 12.2 0.0 2.6 3 0 0 3 3 3 0 F-box domain Mak10 PF04112.8 ESA01663.1 - 1.2e-15 57.0 0.4 6.8e-15 54.6 0.0 2.3 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Glyco_transf_34 PF05637.7 ESA01664.1 - 3e-21 76.0 0.3 4.3e-20 72.2 0.2 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 ESA01664.1 - 6.1e-07 28.9 0.0 1.2e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_8 PF01501.15 ESA01664.1 - 4.8e-05 22.8 0.1 9.1e-05 21.9 0.1 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 F-box-like PF12937.2 ESA01665.1 - 1.4e-05 24.6 0.1 1.4e-05 24.6 0.1 2.6 3 0 0 3 3 3 1 F-box-like zf-FCS PF06467.9 ESA01665.1 - 8.1 6.1 10.7 18 5.0 6.6 2.2 2 1 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Uricase PF01014.13 ESA01666.1 - 2.6e-75 251.0 2.6 4.4e-39 133.7 1.1 2.0 2 0 0 2 2 2 2 Uricase FolB PF02152.13 ESA01666.1 - 0.063 13.4 0.9 0.14 12.3 0.2 1.9 2 0 0 2 2 2 0 Dihydroneopterin aldolase Pkinase PF00069.20 ESA01668.1 - 6.5e-25 87.7 0.0 1.7e-24 86.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01668.1 - 4.6e-22 78.3 0.0 5.5e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA01668.1 - 0.0012 18.6 0.1 0.0055 16.4 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA01668.1 - 0.0018 17.3 0.0 0.0024 16.9 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family E1-E2_ATPase PF00122.15 ESA01669.1 - 1.1e-65 220.9 2.1 1.1e-65 220.9 1.5 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA01669.1 - 1.8e-48 164.4 11.0 1.9e-48 164.3 5.7 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA01669.1 - 8.5e-33 114.5 0.0 4.1e-32 112.3 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA01669.1 - 1.5e-22 79.3 0.1 3.1e-22 78.3 0.1 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 ESA01669.1 - 2.8e-18 65.1 0.1 2.8e-18 65.1 0.0 2.7 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESA01669.1 - 5.4e-18 65.8 0.1 1.3e-17 64.5 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA01669.1 - 5e-08 32.8 5.7 8.3e-07 28.8 0.6 3.3 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA01669.1 - 0.025 14.7 0.0 0.086 13.0 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase PADR1 PF08063.7 ESA01669.1 - 0.14 11.5 0.1 0.3 10.5 0.1 1.5 1 0 0 1 1 1 0 PADR1 (NUC008) domain SOR_SNZ PF01680.12 ESA01670.1 - 2.5e-115 383.3 4.8 4.2e-115 382.5 3.3 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 ESA01670.1 - 2.7e-08 33.1 7.3 4.9e-07 29.0 0.1 2.6 1 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG Dus PF01207.12 ESA01670.1 - 0.0017 17.2 0.9 0.71 8.6 0.1 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.16 ESA01670.1 - 0.0027 16.7 0.0 0.13 11.2 0.0 2.5 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase NanE PF04131.9 ESA01670.1 - 0.0055 15.6 0.3 0.23 10.3 0.0 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase OMPdecase PF00215.19 ESA01670.1 - 0.016 14.6 0.1 0.6 9.4 0.0 2.4 1 1 1 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family TrkA_N PF02254.13 ESA01670.1 - 0.029 14.3 0.1 1.8 8.6 0.0 3.1 3 0 0 3 3 3 0 TrkA-N domain His_biosynth PF00977.16 ESA01670.1 - 0.042 13.1 0.4 2.5 7.3 0.0 3.0 2 1 0 2 2 2 0 Histidine biosynthesis protein NMO PF03060.10 ESA01670.1 - 0.059 12.5 3.4 0.36 9.9 0.0 2.5 2 1 0 2 2 2 0 Nitronate monooxygenase DUF561 PF04481.7 ESA01670.1 - 0.078 11.9 1.1 12 4.7 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF561) Lsm_C PF14894.1 ESA01670.1 - 6.3 6.3 6.4 1.1 8.7 0.1 3.0 5 0 0 5 5 5 0 Lsm C-terminal WD40 PF00400.27 ESA01671.1 - 1.3e-14 53.3 0.3 0.00017 21.3 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.6 ESA01671.1 - 0.028 14.1 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A FAM92 PF06730.6 ESA01671.1 - 0.14 11.4 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 FAM92 protein F-box-like PF12937.2 ESA01675.1 - 0.00014 21.5 1.3 0.0052 16.4 0.1 2.3 2 0 0 2 2 2 2 F-box-like Band_7 PF01145.20 ESA01676.1 - 0.00032 20.6 0.1 0.00041 20.2 0.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF947 PF06102.7 ESA01677.1 - 0.004 16.9 5.1 0.0067 16.2 3.5 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF947) HALZ PF02183.13 ESA01677.1 - 0.048 13.3 0.8 0.1 12.3 0.2 1.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF904 PF06005.7 ESA01677.1 - 0.082 13.2 6.8 0.19 12.0 4.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) CCDC92 PF14916.1 ESA01677.1 - 0.13 11.8 1.8 0.31 10.6 1.0 2.0 1 1 0 1 1 1 0 Coiled-coil domain of unknown function DivIC PF04977.10 ESA01677.1 - 0.17 11.3 0.3 0.17 11.3 0.2 2.6 2 1 1 3 3 3 0 Septum formation initiator TSC22 PF01166.13 ESA01677.1 - 0.23 11.4 2.5 0.56 10.2 1.7 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family DUF972 PF06156.8 ESA01677.1 - 0.75 10.1 6.8 0.12 12.7 2.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) LAGLIDADG_1 PF00961.14 ESA01678.1 - 1.3e-13 51.3 3.6 4.5e-12 46.4 0.4 2.9 2 1 0 2 2 2 2 LAGLIDADG endonuclease Glyco_transf_10 PF00852.14 ESA01678.1 - 0.008 14.7 0.4 0.012 14.1 0.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DUF1688 PF07958.6 ESA01679.1 - 2e-172 573.4 0.0 2.3e-172 573.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) DUF2419 PF10343.4 ESA01679.1 - 0.068 12.4 0.0 10 5.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2419) Exo_endo_phos PF03372.18 ESA01680.1 - 7.2e-11 42.4 0.0 8.6e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SIP1 PF04938.7 ESA01681.1 - 3e-38 131.4 0.2 4.3e-38 130.9 0.1 1.2 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Uma2 PF05685.7 ESA01682.1 - 8.1e-08 31.8 0.0 1.1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease Sugar_tr PF00083.19 ESA01683.1 - 1.6e-45 155.5 24.7 1.8e-45 155.3 17.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESA01683.1 - 6.7e-22 77.6 23.0 8.8e-22 77.2 16.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 ESA01683.1 - 7e-05 21.3 11.3 7e-05 21.3 7.9 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein PTPS PF01242.14 ESA01687.1 - 0.021 14.4 0.2 0.046 13.3 0.1 1.6 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase DUF3260 PF11658.3 ESA01688.1 - 0.032 12.3 0.0 0.048 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Sigma_reg_N PF13800.1 ESA01688.1 - 0.18 11.8 0.1 0.18 11.8 0.0 3.4 3 1 1 4 4 4 0 Sigma factor regulator N-terminal Cytokin-bind PF09265.5 ESA01689.1 - 0.011 14.8 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding NUC205 PF08168.6 ESA01691.1 - 0.062 12.7 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 NUC205 domain zf-met2 PF12907.2 ESA01694.1 - 0.017 15.1 4.9 0.061 13.2 3.4 2.0 1 0 0 1 1 1 0 Zinc-binding zf-3CxxC PF13695.1 ESA01697.1 - 1.9e-08 34.4 19.3 3.2e-07 30.4 10.4 2.8 2 1 0 2 2 2 1 Zinc-binding domain DUF866 PF05907.8 ESA01697.1 - 0.0015 18.0 3.5 0.0027 17.2 2.4 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zf-3CxxC PF13695.1 ESA01698.1 - 0.0014 18.8 15.7 0.0014 18.8 10.9 4.8 2 2 1 3 3 3 1 Zinc-binding domain DUF4387 PF14330.1 ESA01698.1 - 0.018 15.3 9.0 3.7 7.9 0.6 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4387) INTS2 PF14750.1 ESA01699.1 - 0.024 12.2 2.5 0.029 11.8 1.6 1.2 1 1 0 1 1 1 0 Integrator complex subunit 2 Vac14_Fab1_bd PF12755.2 ESA01699.1 - 0.15 12.4 1.1 0.33 11.3 0.5 1.8 1 1 0 1 1 1 0 Vacuolar 14 Fab1-binding region Uds1 PF15456.1 ESA01699.1 - 0.28 11.1 3.0 0.95 9.4 2.1 1.9 1 1 0 1 1 1 0 Up-regulated During Septation HR1 PF02185.11 ESA01699.1 - 1.2 8.8 9.3 0.14 11.8 1.9 2.5 2 0 0 2 2 2 0 Hr1 repeat CENP-F_leu_zip PF10473.4 ESA01699.1 - 2.3 8.0 18.3 0.81 9.5 7.0 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3287 PF11690.3 ESA01699.1 - 2.9 7.9 6.5 9.2 6.3 0.8 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3287) DUF4463 PF14703.1 ESA01699.1 - 6.2 7.4 10.3 8.6 6.9 5.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4463) Kelch_6 PF13964.1 ESA01700.1 - 0.0082 16.2 0.1 0.02 15.0 0.0 1.7 1 1 0 1 1 1 1 Kelch motif Kelch_6 PF13964.1 ESA01701.1 - 5.7e-05 23.1 1.1 0.38 11.0 0.0 3.6 4 0 0 4 4 4 2 Kelch motif FixH PF05751.6 ESA01701.1 - 0.0011 18.8 0.2 0.002 17.9 0.1 1.4 1 0 0 1 1 1 1 FixH Kelch_4 PF13418.1 ESA01701.1 - 0.0021 17.7 1.3 0.57 9.9 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA01701.1 - 0.0059 16.1 2.7 2.7 7.6 0.0 3.5 2 2 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA01701.1 - 0.011 15.5 0.8 0.31 10.8 0.0 3.2 3 1 0 3 3 3 0 Kelch motif DUF3139 PF11337.3 ESA01701.1 - 0.011 15.9 2.8 0.011 15.9 2.0 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) DUF2681 PF10883.3 ESA01701.1 - 0.012 15.8 0.3 0.025 14.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Afaf PF15339.1 ESA01701.1 - 0.02 14.4 0.4 0.045 13.3 0.0 1.7 2 0 0 2 2 2 0 Acrosome formation-associated factor Phage_holin_4 PF05105.7 ESA01701.1 - 0.12 12.0 1.8 0.19 11.3 0.7 1.7 2 0 0 2 2 2 0 Holin family MLANA PF14991.1 ESA01701.1 - 0.13 12.2 0.2 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein melan-A TMEMspv1-c74-12 PF11044.3 ESA01701.1 - 0.53 9.8 5.3 1.5 8.4 3.7 1.8 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Sigma_reg_N PF13800.1 ESA01701.1 - 1.2 9.2 8.9 0.089 12.8 2.0 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Proteasom_Rpn13 PF04683.8 ESA01702.1 - 0.069 13.2 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Proteasome complex subunit Rpn13 ubiquitin receptor JmjN PF02375.12 ESA01702.1 - 0.81 9.2 4.0 3 7.4 0.0 3.3 4 0 0 4 4 4 0 jmjN domain F-box-like PF12937.2 ESA01703.1 - 9.5e-06 25.2 2.8 9.5e-06 25.2 0.8 1.8 2 0 0 2 2 2 1 F-box-like zf-TRAF PF02176.13 ESA01706.1 - 1.1 9.7 4.3 5.6 7.4 0.0 2.8 3 0 0 3 3 3 0 TRAF-type zinc finger eIF-3c_N PF05470.7 ESA01708.1 - 1e-200 667.8 31.5 1.2e-164 548.6 3.6 3.2 3 1 1 4 4 4 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 ESA01708.1 - 3.8e-15 56.0 0.0 1.7e-14 54.0 0.0 2.2 1 0 0 1 1 1 1 PCI domain Thioredoxin PF00085.15 ESA01709.1 - 9.4e-66 218.0 1.7 8.8e-34 115.3 0.1 2.8 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.7 ESA01709.1 - 2.9e-22 79.1 2.4 3.8e-22 78.7 0.7 1.9 2 0 0 2 2 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.1 ESA01709.1 - 9.5e-15 54.7 6.0 9.9e-07 28.9 0.3 3.7 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESA01709.1 - 1.2e-11 44.5 6.0 7.1e-05 22.8 0.0 4.4 4 2 2 6 6 5 2 Thioredoxin-like Thioredoxin_7 PF13899.1 ESA01709.1 - 1.2e-11 44.4 0.8 1.1e-05 25.3 0.0 2.7 3 0 0 3 3 2 2 Thioredoxin-like Redoxin PF08534.5 ESA01709.1 - 9.5e-08 31.7 0.3 0.0088 15.5 0.0 2.4 2 0 0 2 2 2 2 Redoxin AhpC-TSA PF00578.16 ESA01709.1 - 1.2e-07 31.4 0.1 0.0053 16.4 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_6 PF13848.1 ESA01709.1 - 2e-07 30.9 6.8 0.0019 18.0 0.1 4.2 2 1 2 4 4 4 3 Thioredoxin-like domain ERp29_N PF07912.8 ESA01709.1 - 2.1e-07 30.9 0.2 0.00014 21.7 0.0 2.4 2 0 0 2 2 2 2 ERp29, N-terminal domain TraF PF13728.1 ESA01709.1 - 9.5e-05 21.9 0.0 0.26 10.7 0.0 2.4 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_3 PF13192.1 ESA01709.1 - 0.0001 22.0 0.3 0.69 9.7 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin domain Thioredoxin_4 PF13462.1 ESA01709.1 - 0.00028 20.9 2.0 0.41 10.6 0.4 2.8 2 1 1 3 3 3 2 Thioredoxin HyaE PF07449.6 ESA01709.1 - 0.00048 20.0 0.0 1.8 8.5 0.0 2.7 3 0 0 3 3 3 2 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.1 ESA01709.1 - 0.00049 19.6 0.2 0.68 9.5 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin DDE_Tnp_1_2 PF13586.1 ESA01709.1 - 0.023 14.8 0.0 1.9 8.7 0.0 2.6 2 0 0 2 2 2 0 Transposase DDE domain Mu-like_Com PF10122.4 ESA01709.1 - 0.36 9.9 1.2 8.4 5.5 0.1 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com Pkinase PF00069.20 ESA01710.1 - 4.2e-58 196.5 0.1 9.3e-58 195.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01710.1 - 1.1e-31 109.8 0.0 8.5e-26 90.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESA01710.1 - 1.1e-05 24.5 0.0 0.06 12.3 0.0 2.6 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 ESA01710.1 - 0.03 14.0 0.1 0.078 12.6 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.27 ESA01711.1 - 2.3e-44 147.7 11.3 5e-06 26.2 0.1 11.4 11 0 0 11 11 11 9 WD domain, G-beta repeat E3_UbLigase_EDD PF11547.3 ESA01711.1 - 0.056 12.9 0.3 6 6.4 0.0 2.5 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD DUF3639 PF12341.3 ESA01711.1 - 0.063 13.2 0.1 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3639) Gp_dh_N PF00044.19 ESA01712.1 - 0.023 14.6 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain adh_short PF00106.20 ESA01712.1 - 0.093 12.6 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase adh_short PF00106.20 ESA01713.1 - 2.2e-22 79.7 0.0 1.7e-21 76.8 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA01713.1 - 2.1e-19 70.2 0.2 4.8e-19 69.0 0.2 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA01713.1 - 1.3e-08 34.7 0.0 2.8e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 ESA01713.1 - 0.00016 21.8 0.5 0.00033 20.7 0.3 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 ESA01713.1 - 0.0022 17.4 0.0 0.004 16.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.12 ESA01713.1 - 0.0029 18.0 0.5 0.0056 17.0 0.2 1.7 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent THF_DHG_CYH_C PF02882.14 ESA01713.1 - 0.003 16.6 0.0 0.0071 15.4 0.0 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.1 ESA01713.1 - 0.013 15.7 0.0 0.48 10.7 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 ESA01713.1 - 0.028 14.0 0.5 0.057 13.0 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 ESA01713.1 - 0.058 13.3 0.1 0.22 11.5 0.0 1.9 1 1 0 1 1 1 0 NADH(P)-binding NmrA PF05368.8 ESA01713.1 - 0.061 12.5 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.10 ESA01713.1 - 0.083 11.7 0.1 0.13 11.1 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 ESA01713.1 - 0.13 12.0 0.9 0.85 9.4 0.2 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RGS PF00615.14 ESA01715.1 - 0.094 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Regulator of G protein signaling domain ETRAMP PF09716.5 ESA01717.1 - 0.023 14.6 0.0 0.023 14.6 0.0 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Glycophorin_A PF01102.13 ESA01717.1 - 0.13 12.0 0.2 0.14 11.9 0.1 1.1 1 0 0 1 1 1 0 Glycophorin A Sel1 PF08238.7 ESA01718.1 - 6.8e-48 160.0 10.3 4.2e-10 39.9 0.0 5.3 5 0 0 5 5 5 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA01718.1 - 3e-25 88.7 0.0 1.2e-24 86.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01718.1 - 2.8e-19 69.2 2.6 4.8e-19 68.5 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain MIT PF04212.13 ESA01718.1 - 0.0094 15.8 7.7 1.4 8.8 0.1 3.9 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain APH PF01636.18 ESA01718.1 - 0.044 13.4 0.0 0.23 11.1 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1374 PF07118.6 ESA01718.1 - 0.23 11.6 9.6 0.026 14.6 2.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1374) TPR_11 PF13414.1 ESA01718.1 - 0.86 9.3 14.5 3.9 7.1 0.8 3.5 2 1 1 3 3 3 0 TPR repeat ATP-synt_DE PF00401.15 ESA01718.1 - 0.95 9.3 6.9 2.5 8.0 0.2 3.2 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain ATP-synt_Eps PF04627.8 ESA01719.1 - 6.3e-24 83.2 1.5 7.7e-24 83.0 1.1 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Reo_sigmaC PF04582.7 ESA01721.1 - 0.00018 20.8 4.4 0.00026 20.2 3.0 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF16 PF01519.11 ESA01721.1 - 0.0013 18.9 0.6 0.0039 17.3 0.4 1.9 1 0 0 1 1 1 1 Protein of unknown function DUF16 IncA PF04156.9 ESA01721.1 - 0.0023 17.5 2.1 0.0032 17.0 1.5 1.2 1 0 0 1 1 1 1 IncA protein TBPIP PF07106.8 ESA01721.1 - 0.0029 17.1 5.7 0.0071 15.9 3.9 1.6 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tropomyosin PF00261.15 ESA01721.1 - 0.0036 16.4 1.0 0.0067 15.5 0.7 1.3 1 0 0 1 1 1 1 Tropomyosin TMF_TATA_bd PF12325.3 ESA01721.1 - 0.05 13.3 2.5 0.093 12.4 1.7 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding MCPsignal PF00015.16 ESA01721.1 - 0.06 12.8 1.9 0.12 11.9 1.3 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2951 PF11166.3 ESA01721.1 - 0.065 13.0 6.1 2.8 7.8 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Nsp1_C PF05064.8 ESA01721.1 - 0.068 12.8 3.4 0.14 11.8 2.4 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF904 PF06005.7 ESA01721.1 - 0.95 9.8 6.0 0.52 10.6 0.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF904) NPV_P10 PF05531.7 ESA01721.1 - 1.1 9.5 7.5 21 5.4 5.2 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Peptidase_S10 PF00450.17 ESA01722.1 - 1.8e-96 323.8 0.1 2e-96 323.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1248 PF06852.7 ESA01722.1 - 0.049 12.9 0.0 0.098 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1248) Pkinase PF00069.20 ESA01723.1 - 6.9e-33 113.8 0.1 7.7e-33 113.7 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01723.1 - 1.3e-32 112.8 0.0 1.5e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA01723.1 - 0.014 14.5 0.2 0.025 13.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA01723.1 - 0.081 12.6 0.2 0.2 11.3 0.2 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Methyltransf_23 PF13489.1 ESA01724.1 - 1.1e-09 38.2 0.1 3.8e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA01724.1 - 6.6e-09 36.0 0.0 1.3e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA01724.1 - 3.1e-06 27.5 0.0 9e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA01724.1 - 1.3e-05 24.7 0.0 3.1e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA01724.1 - 7.1e-05 23.3 0.0 0.00014 22.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESA01724.1 - 0.00014 21.5 0.0 0.00024 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA01724.1 - 0.00067 20.1 0.0 0.0016 18.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 ESA01724.1 - 0.019 13.9 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_26 PF13659.1 ESA01724.1 - 0.02 14.9 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESA01724.1 - 0.037 13.3 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ribosomal_L44 PF00935.14 ESA01725.1 - 7.9e-35 118.7 11.8 1.1e-34 118.2 8.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Ribosomal_S4 PF00163.14 ESA01728.1 - 5.3e-14 52.3 3.5 8.8e-14 51.6 2.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 ESA01728.1 - 2.3e-12 46.1 0.0 4.2e-11 42.0 0.0 2.3 2 0 0 2 2 2 1 S4 domain Pkinase_Tyr PF07714.12 ESA01733.1 - 2.6e-35 121.7 0.0 4.6e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01733.1 - 6.3e-27 94.3 0.0 1.2e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Monellin PF09200.5 ESA01733.1 - 0.087 12.4 0.6 7.8 6.2 0.1 2.4 2 0 0 2 2 2 0 Monellin Pkinase_Tyr PF07714.12 ESA01734.1 - 1.7e-32 112.4 0.0 2e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01734.1 - 1.5e-23 83.2 0.0 1.9e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain 4HBT PF03061.17 ESA01734.1 - 0.053 13.6 0.6 1.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily Pkinase_Tyr PF07714.12 ESA01735.1 - 0.031 13.3 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF789 PF05623.7 ESA01736.1 - 0.7 9.3 4.3 0.95 8.8 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) CDC45 PF02724.9 ESA01736.1 - 0.81 7.6 12.7 1.1 7.2 8.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid PF03115.9 ESA01736.1 - 2.4 6.2 6.4 3 5.9 4.5 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Daxx PF03344.10 ESA01736.1 - 3.9 5.8 13.8 4.9 5.4 9.6 1.1 1 0 0 1 1 1 0 Daxx Family Pkinase_Tyr PF07714.12 ESA01737.1 - 7.5e-31 107.1 0.0 8.3e-31 106.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01737.1 - 1.7e-23 83.1 0.0 1.9e-23 82.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain 4HBT PF03061.17 ESA01737.1 - 0.057 13.5 0.5 4.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily DUF1861 PF08950.5 ESA01738.1 - 0.0028 16.5 0.0 0.0053 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) AAA_29 PF13555.1 ESA01741.1 - 0.025 14.1 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arch_ATPase PF01637.13 ESA01741.1 - 0.032 13.9 0.3 0.18 11.4 0.0 2.1 1 1 1 2 2 2 0 Archaeal ATPase AAA_14 PF13173.1 ESA01741.1 - 0.08 12.8 0.7 0.23 11.3 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESA01742.1 - 0.016 15.1 2.1 0.042 13.7 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 ESA01742.1 - 0.04 14.1 0.0 0.39 10.9 0.0 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Kelch_5 PF13854.1 ESA01744.1 - 1.4e-21 75.9 11.4 5.2e-05 23.0 0.2 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 ESA01744.1 - 4.3e-20 70.9 9.1 6.2e-05 22.9 0.1 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA01744.1 - 9.6e-20 69.8 8.9 5.9e-07 28.9 0.4 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 ESA01744.1 - 2.1e-15 56.2 11.3 0.00039 20.1 0.0 5.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA01744.1 - 8.2e-15 54.4 2.9 0.00026 21.0 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA01744.1 - 9.6e-14 50.5 1.8 0.0077 15.9 0.0 5.1 5 0 0 5 5 5 4 Kelch motif Herpes_gE PF02480.11 ESA01744.1 - 0.01 14.1 0.1 0.014 13.7 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E DUF1365 PF07103.6 ESA01746.1 - 3.7e-43 147.4 0.3 5.9e-43 146.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) NAD_binding_8 PF13450.1 ESA01748.1 - 3.2e-13 49.4 0.0 7.6e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 ESA01748.1 - 1.5e-08 34.1 0.0 3.7e-06 26.2 0.0 2.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 ESA01748.1 - 1.5e-05 24.1 0.1 2.8e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESA01748.1 - 0.00027 21.0 0.0 0.0011 19.0 0.0 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA01748.1 - 0.00038 20.2 0.0 0.0084 15.8 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 ESA01748.1 - 0.00079 18.3 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 ESA01748.1 - 0.0011 18.8 0.0 0.057 13.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESA01748.1 - 0.1 13.0 0.1 0.34 11.3 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 ESA01748.1 - 0.12 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF1861 PF08950.5 ESA01749.1 - 0.057 12.2 0.0 0.093 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) DUF1861 PF08950.5 ESA01750.1 - 0.0045 15.8 0.0 0.0072 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) Pox_H7 PF04787.7 ESA01750.1 - 0.019 14.7 1.3 0.057 13.2 0.5 2.1 1 1 0 1 1 1 0 Late protein H7 PEX11 PF05648.9 ESA01751.1 - 0.1 11.8 0.3 0.12 11.6 0.2 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) TSGP1 PF07771.6 ESA01751.1 - 1.6 8.6 4.7 1.9 8.3 3.3 1.1 1 0 0 1 1 1 0 Tick salivary peptide group 1 p450 PF00067.17 ESA01759.1 - 6.3e-72 242.5 0.1 1e-71 241.8 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 ESA01761.1 - 0.002 17.8 0.6 0.0055 16.3 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA01762.1 - 0.00023 20.8 1.2 0.00059 19.4 0.8 1.8 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA01764.1 - 0.054 13.2 8.5 0.25 11.1 0.6 3.8 3 1 0 3 3 3 0 Leucine rich repeat DLH PF01738.13 ESA01766.1 - 5.2e-21 74.9 0.0 6.9e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 ESA01766.1 - 7.3e-09 35.5 0.0 1.2e-08 34.8 0.0 1.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.6 ESA01766.1 - 0.088 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.13 ESA01767.1 - 6.3e-22 77.9 0.0 7.6e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 ESA01767.1 - 2.2e-06 27.4 0.0 9.5e-06 25.4 0.0 1.8 1 1 0 2 2 2 1 Alpha/beta hydrolase family BTB PF00651.26 ESA01768.1 - 5.2e-16 58.6 0.1 8.8e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3582 PF12122.3 ESA01768.1 - 0.12 12.3 1.2 0.25 11.3 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3582) ESAG1 PF03238.8 ESA01769.1 - 0.35 10.1 1.9 0.44 9.8 1.3 1.1 1 0 0 1 1 1 0 ESAG protein Atrophin-1 PF03154.10 ESA01772.1 - 5 5.1 14.2 5 5.1 9.8 1.0 1 0 0 1 1 1 0 Atrophin-1 family Acyl-CoA_dh_1 PF00441.19 ESA01775.1 - 3.8e-27 95.2 0.2 6.1e-27 94.5 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 ESA01775.1 - 1.7e-14 53.0 0.1 3.2e-14 52.1 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 ESA01775.1 - 2.9e-14 53.6 0.0 5.3e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 ESA01775.1 - 9.3e-10 38.8 0.0 1.8e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RNase_T PF00929.19 ESA01776.1 - 5e-24 85.4 0.0 6.5e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Exonuclease Involucrin2 PF06994.6 ESA01777.1 - 0.12 12.3 0.9 0.29 11.1 0.6 1.5 1 1 0 1 1 1 0 Involucrin Casein PF00363.13 ESA01777.1 - 0.64 10.6 3.3 0.88 10.2 0.4 2.3 2 1 0 2 2 2 0 Casein Peptidase_M4 PF01447.13 ESA01778.1 - 0.021 14.9 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain ABA_GPCR PF12430.3 ESA01779.1 - 6.2e-51 172.3 13.9 6.2e-51 172.3 9.7 1.9 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 ESA01779.1 - 1.6e-20 72.9 0.0 1.6e-20 72.9 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3735) DUF1129 PF06570.6 ESA01779.1 - 8.8 5.5 14.3 0.052 12.8 2.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) DUF2454 PF10521.4 ESA01780.1 - 5.2e-43 147.0 1.1 7.6e-43 146.5 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) Phytochelatin PF05023.9 ESA01781.1 - 3.9e-70 235.1 0.0 4.3e-70 235.0 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase eIF-6 PF01912.13 ESA01782.1 - 0.021 13.9 0.1 0.022 13.8 0.1 1.0 1 0 0 1 1 1 0 eIF-6 family FlaC_arch PF05377.6 ESA01782.1 - 0.15 11.9 0.5 0.33 10.8 0.1 1.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PRKCSH PF07915.8 ESA01783.1 - 2.6e-17 63.3 4.8 2.6e-17 63.3 3.3 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 ESA01783.1 - 2.1e-05 24.0 1.0 3.3e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein DUF1542 PF07564.6 ESA01784.1 - 0.12 12.4 0.5 0.24 11.4 0.3 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF2576 PF10845.3 ESA01784.1 - 2 7.6 4.4 1.1 8.5 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2576) Exo_endo_phos_2 PF14529.1 ESA01785.1 - 4.4e-11 42.4 4.0 6.6e-11 41.8 0.8 3.0 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase CCDC155 PF14662.1 ESA01785.1 - 0.01 15.4 3.0 0.018 14.6 2.1 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 MbeD_MobD PF04899.7 ESA01785.1 - 0.026 14.4 1.0 0.098 12.5 0.3 2.2 1 1 2 3 3 3 0 MbeD/MobD like DUF904 PF06005.7 ESA01785.1 - 0.11 12.8 7.5 0.32 11.3 2.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF904) IncA PF04156.9 ESA01785.1 - 0.68 9.5 3.2 1.2 8.6 2.2 1.3 1 0 0 1 1 1 0 IncA protein zf-SNAP50_C PF12251.3 ESA01786.1 - 7.6e-59 198.3 2.4 1.2e-58 197.7 1.7 1.3 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal GNAT_acetyltr_2 PF13718.1 ESA01787.1 - 1.9e-81 272.0 0.0 3.5e-81 271.2 0.0 1.4 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 ESA01787.1 - 1.3e-64 217.1 0.0 5.1e-64 215.1 0.0 2.0 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.6 ESA01787.1 - 3e-42 142.2 0.1 9e-42 140.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 ESA01787.1 - 6.6e-35 119.2 0.5 2.3e-34 117.4 0.3 2.0 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 ESA01787.1 - 0.013 15.6 0.0 0.038 14.1 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.24 ESA01787.1 - 0.041 13.3 0.4 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase Ribosomal_L28e PF01778.12 ESA01788.1 - 2.7e-33 114.8 1.5 2.7e-33 114.8 1.0 2.6 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.9 ESA01788.1 - 9.8e-22 76.9 13.3 9.8e-22 76.9 9.2 2.7 2 1 1 3 3 3 1 Mak16 protein C-terminal region Nop14 PF04147.7 ESA01788.1 - 0.057 11.3 26.3 0.063 11.2 18.2 1.1 1 0 0 1 1 1 0 Nop14-like family Arabinose_Isome PF02610.10 ESA01788.1 - 0.29 10.0 5.7 0.43 9.4 3.9 1.5 1 1 0 1 1 1 0 L-arabinose isomerase WD40 PF00400.27 ESA01789.1 - 4.8e-20 70.6 15.2 2.5e-06 27.1 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Plus-3 PF03126.13 ESA01790.1 - 2.2e-28 98.4 0.2 2.2e-28 98.4 0.1 2.3 3 0 0 3 3 3 1 Plus-3 domain DUF2789 PF10982.3 ESA01792.1 - 0.036 14.0 0.0 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) Methyltransf_24 PF13578.1 ESA01793.1 - 1.3e-16 61.3 0.0 2.4e-16 60.5 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.12 ESA01793.1 - 4.1e-10 39.0 0.3 5.3e-10 38.7 0.2 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 ESA01793.1 - 0.0011 19.5 0.0 0.0017 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Lum_binding PF00677.12 ESA01793.1 - 0.17 11.8 0.8 0.69 9.8 0.3 2.1 1 1 1 2 2 2 0 Lumazine binding domain Methyltransf_24 PF13578.1 ESA01794.1 - 2.1e-19 70.3 0.0 3.4e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA01794.1 - 4.2e-06 27.2 0.0 6.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 ESA01794.1 - 7.8e-06 25.0 0.8 2.2e-05 23.6 0.6 1.6 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 ESA01794.1 - 0.0001 22.0 0.0 0.00017 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA01794.1 - 0.0026 17.3 0.1 0.031 13.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA01794.1 - 0.0062 16.5 0.0 0.008 16.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase CmcI PF04989.7 ESA01794.1 - 0.042 13.1 0.1 0.11 11.8 0.1 1.7 1 1 0 1 1 1 0 Cephalosporin hydroxylase Methyltransf_12 PF08242.7 ESA01794.1 - 0.063 13.7 0.1 0.2 12.1 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Tox-SGS PF15651.1 ESA01795.1 - 0.032 14.0 0.2 0.088 12.5 0.2 1.7 1 0 0 1 1 1 0 Salivary glad secreted protein domain toxin T2SM PF04612.7 ESA01801.1 - 0.045 13.5 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M DUF2538 PF10804.3 ESA01802.1 - 0.0029 17.5 0.3 0.0054 16.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2538) Pyr_redox_dim PF02852.17 ESA01802.1 - 0.13 12.2 0.0 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Lipoprotein_10 PF03202.8 ESA01804.1 - 0.051 13.5 0.9 0.11 12.4 0.6 1.6 1 0 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region DUF3735 PF12537.3 ESA01804.1 - 0.43 10.6 0.1 0.43 10.6 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3735) Rap_GAP PF02145.10 ESA01808.1 - 3.8e-17 62.2 0.2 1.1e-16 60.7 0.0 2.0 2 0 0 2 2 2 1 Rap/ran-GAP DNA_pol3_delta PF06144.8 ESA01808.1 - 0.15 11.5 1.1 0.69 9.4 0.0 2.3 3 0 0 3 3 3 0 DNA polymerase III, delta subunit hDGE_amylase PF14701.1 ESA01809.1 - 8.1e-163 542.2 0.6 7.4e-161 535.7 0.4 2.2 1 1 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 ESA01809.1 - 1.1e-116 389.6 0.0 1.7e-116 388.9 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 ESA01809.1 - 1.7e-73 246.9 0.0 3.3e-73 246.0 0.0 1.5 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 ESA01809.1 - 3.5e-19 68.4 0.1 7.8e-19 67.3 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme tRNA-synt_1b PF00579.20 ESA01810.1 - 1.9e-76 257.0 0.1 2.6e-76 256.5 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.20 ESA01810.1 - 1.2e-06 27.7 0.6 2.9e-06 26.6 0.1 1.9 2 0 0 2 2 2 1 S4 domain CbiK PF06180.6 ESA01810.1 - 0.025 13.6 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Cobalt chelatase (CbiK) Mod_r PF07200.8 ESA01811.1 - 4.2e-31 107.9 14.4 5.1e-31 107.6 10.0 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Prominin PF05478.6 ESA01811.1 - 0.011 13.2 7.5 0.013 13.0 5.2 1.0 1 0 0 1 1 1 0 Prominin Vps23_core PF09454.5 ESA01811.1 - 0.076 12.6 0.2 0.21 11.2 0.1 1.8 2 0 0 2 2 2 0 Vps23 core domain eIF-4B PF06273.6 ESA01811.1 - 0.62 8.7 2.5 0.75 8.4 1.7 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Sec20 PF03908.8 ESA01811.1 - 0.86 9.3 7.0 1.7 8.4 0.6 2.7 1 1 2 3 3 3 0 Sec20 Mgr1 PF08602.5 ESA01811.1 - 0.9 8.4 4.2 1.2 8.0 2.9 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Dimer_Tnp_hAT PF05699.9 ESA01812.1 - 7.2e-12 44.7 0.0 7.7e-12 44.6 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region NOSIC PF08060.8 ESA01812.1 - 0.14 11.9 0.0 8 6.3 0.0 2.2 2 0 0 2 2 2 0 NOSIC (NUC001) domain RdRP PF05183.7 ESA01813.1 - 1.6e-114 383.7 0.0 2.3e-114 383.2 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase ACOX PF01756.14 ESA01814.1 - 6.3e-37 126.7 0.1 1e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.1 ESA01814.1 - 2.6e-21 76.2 0.1 5.7e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.14 ESA01814.1 - 1.9e-08 33.6 0.1 4e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.19 ESA01814.1 - 0.00052 20.1 0.0 0.0028 17.7 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Toxin_ToxA PF11584.3 ESA01816.1 - 0.12 12.1 0.1 0.82 9.5 0.1 1.9 1 1 1 2 2 2 0 Proteinaceous host-selective toxin ToxA MAGE_N PF12440.3 ESA01816.1 - 1.7 8.9 10.4 0.062 13.5 3.0 1.7 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal DUF2026 PF09641.5 ESA01819.1 - 0.094 12.0 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2026) Rad50_zn_hook PF04423.9 ESA01820.1 - 0.067 12.6 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif Pkinase_Tyr PF07714.12 ESA01822.1 - 2.7e-30 105.3 0.0 4.3e-30 104.6 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01822.1 - 6.6e-27 94.2 0.3 1.4e-26 93.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain CPSase_L_D3 PF02787.14 ESA01822.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.7 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain APH PF01636.18 ESA01822.1 - 0.068 12.9 1.5 0.14 11.9 0.9 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family BACK PF07707.10 ESA01823.1 - 1.3e-08 34.6 0.6 1.3e-06 28.1 0.1 3.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA01823.1 - 1.1e-05 25.4 0.1 2.3e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01824.1 - 3.3e-08 33.3 0.4 9.4e-07 28.6 0.0 3.3 3 1 0 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA01824.1 - 4e-06 26.7 0.1 9.1e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA01826.1 - 5.2e-10 39.2 0.0 1e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01826.1 - 2.4e-08 33.7 0.6 1.4e-06 28.0 0.0 3.4 3 1 1 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA01827.1 - 2.9e-12 46.5 0.7 5.4e-12 45.6 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA01827.1 - 5.5e-09 35.7 1.5 5.8e-06 26.0 0.0 4.1 3 1 1 4 4 4 2 BTB And C-terminal Kelch Arb1 PF09692.5 ESA01829.1 - 1.8e-07 30.4 0.1 1.8e-07 30.4 0.1 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 DUF3526 PF12040.3 ESA01829.1 - 0.04 14.0 0.2 0.048 13.7 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3526) DUF4359 PF14271.1 ESA01830.1 - 0.092 13.1 1.8 0.11 12.9 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) TPR_MLP1_2 PF07926.7 ESA01830.1 - 0.45 10.2 11.6 0.043 13.5 4.3 2.0 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NICE-3 PF07406.6 ESA01830.1 - 0.58 9.6 4.2 1.8 8.0 0.1 2.2 1 1 1 2 2 2 0 NICE-3 protein GBP PF02263.14 ESA01831.1 - 8.5e-45 152.8 0.0 3.9e-44 150.6 0.0 1.8 1 1 0 1 1 1 1 Guanylate-binding protein, N-terminal domain PhrC_PhrF PF11131.3 ESA01831.1 - 0.11 12.0 0.6 0.2 11.2 0.4 1.3 1 0 0 1 1 1 0 Rap-phr extracellular signalling Amidase PF01425.16 ESA01831.1 - 0.14 10.9 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Amidase Band_7 PF01145.20 ESA01832.1 - 6.2e-19 68.5 0.7 6.2e-19 68.5 0.5 2.3 2 1 0 2 2 2 1 SPFH domain / Band 7 family Nefa_Nip30_N PF10187.4 ESA01833.1 - 0.014 15.5 1.4 0.014 15.5 0.9 1.0 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 Orthopox_F8 PF05886.6 ESA01833.1 - 0.044 13.6 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Orthopoxvirus F8 protein DUF4295 PF14128.1 ESA01833.1 - 0.087 12.4 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) Ni_hydr_CYTB PF01292.15 ESA01834.1 - 0.0024 17.2 1.1 0.0043 16.4 0.7 1.5 1 1 0 1 1 1 1 Prokaryotic cytochrome b561 DUF2269 PF10027.4 ESA01834.1 - 0.034 13.9 1.0 0.05 13.3 0.7 1.4 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2269) Herpes_UL45 PF05473.7 ESA01834.1 - 0.089 12.2 1.3 0.1 12.0 0.1 1.7 1 1 0 1 1 1 0 UL45 protein Cytochrom_B_N PF00033.14 ESA01834.1 - 0.1 11.9 5.4 5.3 6.3 0.4 2.2 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB MARVEL PF01284.18 ESA01834.1 - 0.18 11.6 5.9 0.65 9.8 4.1 2.0 1 1 0 1 1 1 0 Membrane-associating domain OAD_gamma PF04277.8 ESA01834.1 - 0.22 11.8 2.2 4.7 7.6 0.0 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain PTPLA PF04387.9 ESA01834.1 - 0.99 8.8 7.6 17 4.7 4.0 2.7 2 1 0 2 2 2 0 Protein tyrosine phosphatase-like protein, PTPLA OppC_N PF12911.2 ESA01834.1 - 1.3 8.4 11.7 1.9 7.9 1.8 3.3 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF3784 PF12650.2 ESA01834.1 - 4.4 7.3 17.8 0.71 9.8 7.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) Methyltransf_11 PF08241.7 ESA01835.1 - 2.4e-06 27.9 0.0 5.4e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA01835.1 - 4.3e-06 26.5 0.0 9.3e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Dynamitin PF04912.9 ESA01837.1 - 0.01 14.6 0.1 0.019 13.8 0.0 1.4 1 0 0 1 1 1 0 Dynamitin Sugarporin_N PF11471.3 ESA01837.1 - 0.016 14.8 5.3 0.03 13.9 3.6 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Kinetocho_Slk19 PF12709.2 ESA01837.1 - 0.031 14.3 1.3 0.99 9.5 0.0 2.8 2 1 0 2 2 2 0 Central kinetochore-associated Med4 PF10018.4 ESA01837.1 - 0.072 12.4 0.4 0.12 11.8 0.3 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 FlgM PF04316.8 ESA01837.1 - 0.49 10.3 2.3 29 4.6 1.2 2.5 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM V-SNARE PF05008.10 ESA01837.1 - 0.9 9.7 4.4 0.44 10.7 0.9 2.0 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus TLD PF07534.11 ESA01838.1 - 1.4e-11 44.5 0.5 2.4e-11 43.7 0.3 1.4 1 0 0 1 1 1 1 TLD Sad1_UNC PF07738.8 ESA01839.1 - 0.018 14.8 0.0 0.087 12.6 0.0 2.1 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal LRR_6 PF13516.1 ESA01839.1 - 0.97 9.7 5.0 20 5.6 0.1 4.2 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.1 ESA01839.1 - 1.1 9.0 9.9 0.57 9.9 0.6 4.0 3 1 1 4 4 4 0 Leucine rich repeat zf-BED PF02892.10 ESA01840.1 - 4.5e-06 26.3 3.2 2e-05 24.2 2.2 2.0 1 1 0 1 1 1 1 BED zinc finger Peptidase_U57 PF05582.7 ESA01840.1 - 0.025 13.5 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 YabG peptidase U57 zf-met2 PF12907.2 ESA01840.1 - 0.23 11.4 1.1 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Zinc-binding zf-C2H2_4 PF13894.1 ESA01840.1 - 0.41 11.0 2.2 4 8.0 1.5 2.4 1 1 0 1 1 1 0 C2H2-type zinc finger Phosphodiest PF01663.17 ESA01841.1 - 1.4e-09 37.7 0.3 4.7e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 ESA01841.1 - 0.13 11.6 0.0 0.45 9.8 0.0 1.8 1 1 0 1 1 1 0 Metalloenzyme superfamily CPSase_L_D2 PF02786.12 ESA01842.1 - 6.4e-67 224.9 0.0 1.2e-66 223.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESA01842.1 - 3.6e-40 136.4 0.0 6.9e-40 135.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESA01842.1 - 6.6e-31 106.4 0.0 1.5e-30 105.2 0.0 1.6 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 ESA01842.1 - 2.7e-13 49.3 0.1 7e-13 48.0 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 ESA01842.1 - 3.6e-10 39.1 0.0 5.7e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 ESA01842.1 - 4.1e-10 39.4 0.0 8.9e-10 38.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.1 ESA01842.1 - 2.4e-09 37.1 0.0 5.1e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 ESA01842.1 - 7.3e-07 29.1 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESA01842.1 - 6.3e-06 25.7 0.0 0.018 14.6 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.17 ESA01842.1 - 3.4e-05 23.2 0.0 9.1e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 ESA01842.1 - 0.00021 20.8 0.0 0.00086 18.8 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_2 PF12700.2 ESA01842.1 - 0.067 12.3 0.0 1.2 8.2 0.0 2.2 1 1 1 2 2 2 0 HlyD family secretion protein HlyD PF00529.15 ESA01842.1 - 0.24 10.6 0.2 5.6 6.1 0.1 2.3 2 0 0 2 2 2 0 HlyD family secretion protein Flavoprotein PF02441.14 ESA01843.1 - 9.3e-46 154.6 0.2 1.3e-45 154.2 0.1 1.2 1 0 0 1 1 1 1 Flavoprotein NDK PF00334.14 ESA01844.1 - 1.3e-51 173.8 0.0 1.5e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase WD40 PF00400.27 ESA01845.1 - 2.2e-08 33.6 2.1 0.0026 17.5 0.2 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat Stig1 PF04885.8 ESA01845.1 - 0.35 11.0 4.4 1.5 9.0 2.3 2.1 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 TOM20_plant PF06552.7 ESA01846.1 - 0.0074 15.8 0.1 0.018 14.6 0.1 1.7 1 0 0 1 1 1 1 Plant specific mitochondrial import receptor subunit TOM20 DUF3899 PF13038.1 ESA01846.1 - 0.33 11.1 1.4 15 5.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) TPR_2 PF07719.12 ESA01846.1 - 0.69 9.9 4.3 11 6.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat E7 PF00527.13 ESA01846.1 - 1.2 9.3 5.5 18 5.6 0.1 3.0 3 0 0 3 3 3 0 E7 protein, Early protein DUF2098 PF09871.4 ESA01846.1 - 5.3 7.0 10.2 6.1 6.8 2.4 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) RdRP PF05183.7 ESA01848.1 - 3.4e-112 376.0 0.1 4.9e-112 375.5 0.1 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase NTP_transferase PF00483.18 ESA01850.1 - 8.2e-49 166.1 0.0 1.1e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 ESA01850.1 - 3.7e-11 42.0 6.2 9.4e-10 37.5 0.9 3.5 2 1 1 3 3 3 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 ESA01850.1 - 9e-10 38.8 0.0 1.2e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 ESA01850.1 - 7e-05 22.3 1.2 7e-05 22.3 0.9 2.7 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase SRP54 PF00448.17 ESA01850.1 - 0.031 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Apc5 PF12862.2 ESA01852.1 - 5.3e-23 80.6 1.7 2.3e-22 78.6 0.1 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.1 ESA01852.1 - 2.5e-05 24.1 3.0 0.12 12.3 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA01852.1 - 0.0094 16.5 0.4 14 6.6 0.0 4.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA01852.1 - 0.061 13.1 0.1 0.45 10.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA01852.1 - 0.12 12.4 10.3 11 6.2 0.2 4.8 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESA01852.1 - 3.8 7.4 7.2 5.2 7.0 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat BTB PF00651.26 ESA01853.1 - 1.2e-15 57.4 0.3 2.7e-15 56.2 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA01853.1 - 5.3e-13 49.1 0.2 3.1e-12 46.6 0.1 2.4 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA01853.1 - 2.5e-05 24.0 1.9 0.00027 20.7 0.5 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF4389 PF14333.1 ESA01855.1 - 0.078 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF1323 PF07037.6 ESA01856.1 - 0.088 12.9 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) UIM PF02809.15 ESA01857.1 - 0.0004 19.7 1.4 0.029 13.9 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif TrmB PF01978.14 ESA01857.1 - 0.13 12.0 0.2 0.31 10.7 0.0 1.7 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB Ribosomal_L11 PF00298.14 ESA01858.1 - 1.7e-27 95.3 0.4 2.3e-27 94.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.9 ESA01858.1 - 3.5e-22 77.6 0.1 8.6e-22 76.3 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Lyase_1 PF00206.15 ESA01861.1 - 5.2e-120 400.3 0.0 6.8e-120 399.9 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 ESA01861.1 - 1.1e-25 89.4 0.5 2.3e-25 88.4 0.1 1.8 2 0 0 2 2 2 1 Fumarase C C-terminus Tox-ART-HYD1 PF15633.1 ESA01861.1 - 0.019 15.7 0.1 0.042 14.6 0.0 1.6 1 0 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase Fork_head PF00250.13 ESA01862.1 - 1.3e-27 95.6 0.3 1.3e-27 95.6 0.2 2.0 2 1 0 2 2 2 1 Fork head domain Rtf2 PF04641.7 ESA01862.1 - 0.0059 15.8 7.1 0.011 14.9 4.9 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger DUF4124 PF13511.1 ESA01862.1 - 5.4 7.1 7.7 0.78 9.8 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4124) Peptidase_M9 PF01752.12 ESA01864.1 - 0.016 14.1 0.2 0.034 13.0 0.1 1.5 2 0 0 2 2 2 0 Collagenase RVT_1 PF00078.22 ESA01865.1 - 4.7e-05 22.8 0.0 5.4e-05 22.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 ESA01866.1 - 0.00045 19.6 0.0 0.0005 19.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Beach PF02138.13 ESA01866.1 - 0.012 15.1 0.1 0.012 15.0 0.1 1.1 1 0 0 1 1 1 0 Beige/BEACH domain ATG19_autophagy PF12744.2 ESA01866.1 - 0.11 11.7 4.3 0.077 12.2 1.3 1.7 1 1 1 2 2 2 0 Autophagy protein Atg19, Atg8-binding Sel1 PF08238.7 ESA01867.1 - 3.3e-79 259.5 36.7 1.9e-09 37.8 0.2 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA01867.1 - 0.99 10.0 17.3 2.1 9.0 0.0 6.1 9 0 0 9 9 9 0 Tetratricopeptide repeat zf-CCHC_2 PF13696.1 ESA01868.1 - 0.044 13.2 0.5 0.14 11.7 0.4 1.8 1 0 0 1 1 1 0 Zinc knuckle DUF240 PF03086.9 ESA01869.1 - 0.039 13.5 0.4 0.058 13.0 0.2 1.4 1 1 0 1 1 1 0 MG032/MG096/MG288 family 2 Myosin_head PF00063.16 ESA01869.1 - 0.065 11.2 0.6 0.07 11.1 0.4 1.0 1 0 0 1 1 1 0 Myosin head (motor domain) Pkinase PF00069.20 ESA01872.1 - 1.1e-13 50.9 0.2 6.4e-13 48.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01872.1 - 6.4e-06 25.4 0.1 1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA01872.1 - 2e-05 24.4 0.0 2.5e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA01872.1 - 0.00056 18.9 0.0 0.00071 18.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.15 ESA01872.1 - 0.00058 19.5 0.0 0.0008 19.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 ESA01872.1 - 0.00066 19.0 0.0 0.00077 18.8 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA01872.1 - 0.01 14.9 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA01872.1 - 0.053 12.7 0.2 0.073 12.2 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF2737 PF10930.3 ESA01872.1 - 0.081 12.5 0.1 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) Seadorna_VP7 PF07387.6 ESA01872.1 - 0.099 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_Tyr PF07714.12 ESA01873.1 - 1.4e-05 24.3 0.1 1.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01873.1 - 0.0003 20.0 0.0 0.0005 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA01874.1 - 3.3e-38 131.3 0.0 4.1e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01874.1 - 1.6e-34 119.1 0.0 1.9e-34 118.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA01874.1 - 8.4e-05 21.7 0.0 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA01874.1 - 0.0032 16.8 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA01874.1 - 0.046 13.4 0.0 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA01874.1 - 0.052 12.3 0.1 0.097 11.4 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.1 ESA01874.1 - 0.081 11.8 0.0 0.097 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESA01874.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PAN_4 PF14295.1 ESA01878.1 - 9.5e-05 22.0 3.8 9.5e-05 22.0 2.6 2.1 3 0 0 3 3 3 1 PAN domain Macoilin PF09726.4 ESA01878.1 - 3.1 5.9 8.5 3.8 5.6 5.9 1.1 1 0 0 1 1 1 0 Transmembrane protein SAM_1 PF00536.25 ESA01879.1 - 5.3e-05 23.3 0.2 0.00042 20.4 0.1 2.3 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA01879.1 - 0.0085 15.9 0.1 0.056 13.2 0.1 2.2 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 ESA01879.1 - 0.068 12.9 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Ribosomal_L14e PF01929.12 ESA01882.1 - 6.7e-27 93.6 6.0 8.9e-27 93.2 4.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 ESA01882.1 - 3.8e-07 29.5 0.1 4.4e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 KOW motif SH3_9 PF14604.1 ESA01883.1 - 1.2e-17 63.2 0.1 1.7e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 ESA01883.1 - 1.1e-15 56.6 0.2 1.8e-15 56.0 0.2 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA01883.1 - 1.9e-11 43.2 0.0 2.9e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Rep_fac_C PF08542.6 ESA01884.1 - 3.3e-17 62.2 0.9 1e-16 60.6 0.1 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESA01884.1 - 2.5e-10 40.2 0.0 5.8e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 ESA01884.1 - 1.6e-06 28.3 0.3 6.1e-06 26.4 0.1 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA01884.1 - 2e-05 23.7 0.0 0.0026 16.8 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESA01884.1 - 7e-05 22.8 0.6 0.0022 18.0 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain DNA_pol3_delta PF06144.8 ESA01884.1 - 9.4e-05 21.9 1.1 0.00018 21.0 0.4 1.8 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 ESA01884.1 - 0.00012 22.2 0.2 0.00086 19.4 0.1 2.4 2 1 1 3 3 3 1 AAA domain AAA_11 PF13086.1 ESA01884.1 - 0.0011 18.5 0.1 0.0033 17.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESA01884.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain VPR PF00522.13 ESA01884.1 - 0.024 14.4 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 VPR/VPX protein Bac_DnaA PF00308.13 ESA01884.1 - 0.036 13.7 3.8 0.038 13.6 0.4 2.5 2 1 0 3 3 3 0 Bacterial dnaA protein AAA_19 PF13245.1 ESA01884.1 - 0.068 12.9 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain ABC_tran PF00005.22 ESA01884.1 - 0.076 13.3 0.0 0.19 12.0 0.0 1.6 2 0 0 2 2 2 0 ABC transporter ArgK PF03308.11 ESA01884.1 - 0.11 11.2 0.0 2.1 7.0 0.0 2.2 2 0 0 2 2 2 0 ArgK protein Fes1 PF08609.5 ESA01885.1 - 1e-15 57.9 2.1 2.1e-15 56.9 0.6 2.1 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 ESA01885.1 - 1.1e-05 25.5 0.0 0.0046 17.1 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats Arm PF00514.18 ESA01885.1 - 0.00093 18.9 0.1 1.3 8.9 0.0 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Clathrin PF00637.15 ESA01885.1 - 0.0021 17.6 0.5 0.7 9.4 0.0 2.5 3 0 0 3 3 3 2 Region in Clathrin and VPS V-ATPase_H_N PF03224.9 ESA01885.1 - 0.016 14.2 0.2 0.022 13.9 0.1 1.2 1 0 0 1 1 1 0 V-ATPase subunit H CDC14 PF08045.6 ESA01885.1 - 0.033 13.3 0.0 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Cell division control protein 14, SIN component V-ATPase_H_C PF11698.3 ESA01885.1 - 0.071 13.0 0.0 2.1 8.3 0.0 2.5 2 1 0 3 3 3 0 V-ATPase subunit H HEAT_EZ PF13513.1 ESA01885.1 - 0.097 13.1 0.0 2.1 8.9 0.0 2.9 4 0 0 4 4 4 0 HEAT-like repeat DUF290 PF01060.18 ESA01889.1 - 3.5 7.6 6.2 5.9 6.9 4.3 1.4 1 1 0 1 1 1 0 Transthyretin-like family DDE_1 PF03184.14 ESA01891.1 - 0.00022 20.4 1.0 0.012 14.7 0.0 2.1 2 0 0 2 2 2 2 DDE superfamily endonuclease ADC PF06314.6 ESA01894.1 - 0.13 11.5 0.1 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) DUF3333 PF11812.3 ESA01898.1 - 0.045 13.7 2.6 1.2 9.1 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3333) AIG1 PF04548.11 ESA01900.1 - 2.4e-10 39.9 1.2 2.7e-10 39.7 0.9 1.0 1 0 0 1 1 1 1 AIG1 family PRA-PH PF01503.12 ESA01900.1 - 0.014 15.6 0.4 0.026 14.7 0.1 1.5 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase HMG_box PF00505.14 ESA01904.1 - 1.3e-06 28.5 0.0 2e-06 27.9 0.0 1.3 1 1 0 1 1 1 1 HMG (high mobility group) box HD-ZIP_N PF04618.7 ESA01906.1 - 0.095 13.2 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 HD-ZIP protein N terminus DUF16 PF01519.11 ESA01909.1 - 0.037 14.2 1.9 0.037 14.2 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 zf-C2H2_4 PF13894.1 ESA01910.1 - 0.002 18.3 1.3 0.002 18.3 0.9 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.2 ESA01910.1 - 0.0029 17.7 0.4 0.0072 16.5 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 ESA01910.1 - 0.011 16.0 0.8 0.011 16.0 0.6 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type Nop14 PF04147.7 ESA01910.1 - 0.079 10.8 6.4 0.1 10.4 4.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA01910.1 - 0.39 8.6 7.7 0.54 8.2 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.7 ESA01910.1 - 4.9 6.1 16.2 7.5 5.5 11.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT zf-C2H2_4 PF13894.1 ESA01911.1 - 0.00049 20.2 1.3 0.0021 18.2 0.9 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.2 ESA01911.1 - 0.0032 17.6 0.4 0.0077 16.4 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 ESA01911.1 - 0.0037 17.5 0.8 0.012 15.9 0.6 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type ETC_C1_NDUFA5 PF04716.9 ESA01911.1 - 0.047 13.2 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 ETC complex I subunit conserved region Ly49 PF08391.5 ESA01911.1 - 0.39 10.8 5.5 0.94 9.6 0.6 2.8 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region AAA_12 PF13087.1 ESA01912.1 - 1.5e-37 128.8 1.5 1.5e-37 128.8 1.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA01912.1 - 5e-27 95.0 1.9 5e-27 95.0 1.3 3.3 3 1 0 3 3 3 1 AAA domain DUF2075 PF09848.4 ESA01912.1 - 2.3e-06 26.8 0.1 0.0011 18.0 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 ESA01912.1 - 3.7e-06 26.5 0.0 8.3e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA01912.1 - 2e-05 24.2 0.0 0.0057 16.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESA01912.1 - 0.0097 16.1 0.3 0.38 10.9 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA01912.1 - 0.016 15.2 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 ESA01912.1 - 0.12 11.2 0.3 0.36 9.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_12 PF13087.1 ESA01913.1 - 1.8e-34 118.8 2.4 1.8e-34 118.8 1.7 2.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA01913.1 - 3.4e-26 92.2 5.5 3.4e-26 92.2 3.8 3.5 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.1 ESA01913.1 - 6.8e-06 25.7 0.0 1.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA01913.1 - 7.8e-05 22.3 0.0 0.034 13.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 ESA01913.1 - 7.9e-05 21.7 0.0 7.9e-05 21.7 0.0 3.8 3 1 0 4 4 4 2 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 ESA01913.1 - 0.0069 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 ESA01913.1 - 0.03 14.5 0.2 0.53 10.4 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.1 ESA01913.1 - 0.034 14.2 0.0 0.12 12.4 0.0 2.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DALR_1 PF05746.10 ESA01914.1 - 0.013 15.4 0.2 0.021 14.8 0.1 1.5 1 1 1 2 2 2 0 DALR anticodon binding domain GFRP PF06399.8 ESA01914.1 - 0.034 13.7 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) DUF2434 PF10361.4 ESA01914.1 - 0.046 12.7 0.0 0.057 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) Phage_Treg PF04761.7 ESA01914.1 - 0.052 13.3 0.9 4 7.2 0.1 2.2 1 1 1 2 2 2 0 Lactococcus bacteriophage putative transcription regulator SWIM PF04434.12 ESA01918.1 - 0.081 12.4 1.7 0.15 11.5 1.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger Stimulus_sens_1 PF13756.1 ESA01918.1 - 0.11 12.9 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Stimulus-sensing domain FAR1 PF03101.10 ESA01919.1 - 0.014 15.9 0.9 0.03 14.8 0.7 1.6 1 0 0 1 1 1 0 FAR1 DNA-binding domain Di19_C PF14571.1 ESA01919.1 - 0.23 11.7 2.7 12 6.3 1.9 2.7 1 1 0 1 1 1 0 Stress-induced protein Di19, C-terminal DUF2115 PF09888.4 ESA01922.1 - 0.0038 17.3 2.1 0.01 15.9 0.2 2.4 2 1 1 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2115) Aldo_ket_red PF00248.16 ESA01923.1 - 0.06 12.1 0.0 0.34 9.6 0.0 1.9 1 1 1 2 2 2 0 Aldo/keto reductase family Phage_Treg PF04761.7 ESA01924.1 - 0.018 14.7 0.6 0.035 13.8 0.4 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator THP2 PF09432.5 ESA01926.1 - 0.06 13.2 0.3 0.068 13.0 0.2 1.2 1 0 0 1 1 1 0 Tho complex subunit THP2 Lambda_CIII PF02061.11 ESA01926.1 - 0.23 11.4 1.2 0.49 10.4 0.1 1.9 2 0 0 2 2 2 0 Lambda Phage CIII ParA PF10609.4 ESA01927.1 - 1.6e-36 124.0 0.3 2.9e-36 123.1 0.2 1.4 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 ESA01927.1 - 3.1e-15 56.1 0.0 4.3e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 ESA01927.1 - 0.0003 20.7 0.0 0.00072 19.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.10 ESA01927.1 - 0.00031 19.9 0.5 0.0014 17.7 0.0 2.0 2 1 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.1 ESA01927.1 - 0.0014 18.0 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain MipZ PF09140.6 ESA01927.1 - 0.0073 15.4 0.0 0.025 13.6 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ ArgK PF03308.11 ESA01927.1 - 0.012 14.4 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 ArgK protein DUF258 PF03193.11 ESA01927.1 - 0.012 14.7 0.2 0.026 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 VirE PF05272.6 ESA01927.1 - 0.021 14.2 0.1 0.038 13.4 0.1 1.3 1 0 0 1 1 1 0 Virulence-associated protein E DDE_Tnp_1_6 PF13751.1 ESA01927.1 - 0.11 12.5 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Transposase DDE domain AAA_29 PF13555.1 ESA01927.1 - 0.15 11.5 0.2 0.38 10.3 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.17 ESA01927.1 - 0.16 10.7 0.1 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain F-box-like PF12937.2 ESA01928.1 - 0.001 18.7 2.7 0.002 17.8 0.5 2.4 2 0 0 2 2 2 1 F-box-like TMF_TATA_bd PF12325.3 ESA01930.1 - 0.0044 16.7 0.3 0.0048 16.6 0.2 1.0 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 ESA01930.1 - 0.0062 16.7 1.6 0.0076 16.5 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF904) NYD-SP28_assoc PF14775.1 ESA01930.1 - 0.0065 16.1 1.3 0.021 14.5 0.9 1.7 1 1 1 2 2 2 1 Sperm tail C-terminal domain IncA PF04156.9 ESA01930.1 - 0.011 15.4 0.7 0.011 15.3 0.5 1.0 1 0 0 1 1 1 0 IncA protein CCDC155 PF14662.1 ESA01930.1 - 0.011 15.2 0.7 0.013 15.1 0.5 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 CCDC92 PF14916.1 ESA01930.1 - 0.015 14.8 1.8 0.12 11.9 0.6 2.3 2 1 0 2 2 2 0 Coiled-coil domain of unknown function TMF_DNA_bd PF12329.3 ESA01930.1 - 0.023 14.4 2.2 0.031 14.0 1.5 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2604 PF10790.4 ESA01930.1 - 0.023 14.8 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF2604) DivIC PF04977.10 ESA01930.1 - 0.044 13.2 2.3 0.09 12.2 1.6 1.6 1 1 0 1 1 1 0 Septum formation initiator Spc7 PF08317.6 ESA01930.1 - 0.045 12.4 0.2 0.046 12.3 0.1 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein bZIP_2 PF07716.10 ESA01930.1 - 0.047 13.5 2.8 0.095 12.5 0.5 2.0 1 1 1 2 2 2 0 Basic region leucine zipper Halo_GVPC PF05465.8 ESA01930.1 - 0.049 13.5 0.9 2.2 8.2 0.1 2.4 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat bZIP_1 PF00170.16 ESA01930.1 - 0.049 13.5 3.2 0.066 13.1 2.1 1.4 1 1 0 1 1 1 0 bZIP transcription factor HALZ PF02183.13 ESA01930.1 - 0.094 12.4 4.0 0.16 11.7 2.8 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper DUF2216 PF10226.4 ESA01930.1 - 0.12 11.9 0.6 0.12 11.9 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) DUF1875 PF08961.5 ESA01930.1 - 0.12 11.6 0.8 0.12 11.6 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) Shugoshin_N PF07558.6 ESA01930.1 - 0.12 12.0 1.3 0.3 10.8 0.9 1.8 1 1 0 1 1 1 0 Shugoshin N-terminal coiled-coil region IFP_35_N PF07334.8 ESA01930.1 - 0.16 11.9 0.4 0.19 11.7 0.3 1.1 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Golgin_A5 PF09787.4 ESA01930.1 - 0.16 10.4 0.5 0.16 10.4 0.3 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF972 PF06156.8 ESA01930.1 - 0.18 12.1 0.5 0.19 12.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TSC22 PF01166.13 ESA01930.1 - 0.29 11.1 2.3 0.44 10.5 1.3 1.5 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF659 PF04937.10 ESA01931.1 - 7.7e-11 41.7 0.1 1.3e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Tnp_P_element PF12017.3 ESA01931.1 - 0.036 13.3 0.1 0.05 12.8 0.1 1.1 1 0 0 1 1 1 0 Transposase protein HSP70 PF00012.15 ESA01932.1 - 3.4e-07 28.5 0.1 0.00017 19.6 0.0 2.5 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA01932.1 - 2.9e-06 26.1 0.0 0.00011 20.9 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein DUF3978 PF13123.1 ESA01935.1 - 0.097 12.0 0.0 0.14 11.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3978) Baculo_PEP_C PF04513.7 ESA01937.1 - 0.03 14.1 0.5 0.03 14.1 0.4 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin PF00804.20 ESA01937.1 - 0.054 13.6 2.2 0.058 13.5 1.5 1.1 1 0 0 1 1 1 0 Syntaxin Cortex-I_coil PF09304.5 ESA01937.1 - 0.12 12.4 2.4 0.13 12.3 1.6 1.2 1 0 0 1 1 1 0 Cortexillin I, coiled coil Phasin PF05597.6 ESA01937.1 - 0.12 12.1 0.9 0.14 11.9 0.6 1.1 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Syntaxin-6_N PF09177.6 ESA01937.1 - 0.14 12.6 0.8 0.14 12.5 0.5 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MitMem_reg PF13012.1 ESA01937.1 - 0.14 12.2 0.6 0.14 12.2 0.4 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function DUF2356 PF10189.4 ESA01937.1 - 0.15 11.1 0.3 0.15 11.1 0.2 1.0 1 0 0 1 1 1 0 Conserved protein (DUF2356) DUF1664 PF07889.7 ESA01937.1 - 0.19 11.5 1.3 0.2 11.4 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TrpBP PF02081.10 ESA01938.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.2 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein DUF616 PF04765.8 ESA01941.1 - 0.033 13.3 0.1 0.058 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF616) zf-RING_5 PF14634.1 ESA01942.1 - 0.0072 16.0 1.4 0.011 15.3 1.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESA01942.1 - 0.036 13.9 0.6 0.069 12.9 0.4 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 ESA01942.1 - 0.093 12.4 0.2 0.2 11.3 0.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger AAA_12 PF13087.1 ESA01943.1 - 3.9e-35 121.0 3.4 3.9e-35 121.0 2.4 2.8 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.1 ESA01943.1 - 1.9e-29 102.8 3.0 1.9e-29 102.8 2.0 3.9 4 1 0 4 4 4 1 AAA domain AAA_19 PF13245.1 ESA01943.1 - 5.4e-07 29.2 0.0 1.1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA01943.1 - 4.2e-05 22.6 5.4 0.0012 17.8 0.0 3.6 2 1 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESA01943.1 - 7.5e-05 22.4 0.0 0.016 14.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.1 ESA01943.1 - 0.024 14.7 0.0 0.11 12.6 0.0 2.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_16 PF13191.1 ESA01943.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 ESA01943.1 - 1 9.5 6.7 1 9.5 0.3 3.7 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Fijivirus_P9-2 PF06837.6 ESA01944.1 - 0.49 9.4 4.3 0.56 9.3 3.0 1.1 1 0 0 1 1 1 0 Fijivirus P9-2 protein Pkinase PF00069.20 ESA01946.1 - 8.2e-12 44.8 0.4 6.9e-09 35.2 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA01946.1 - 1.3e-05 24.3 0.2 0.0025 16.9 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA01946.1 - 0.00085 19.1 0.1 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Abi_2 PF07751.6 ESA01946.1 - 0.016 15.3 0.1 0.039 14.1 0.1 1.7 1 0 0 1 1 1 0 Abi-like protein Amidoligase_2 PF12224.3 ESA01946.1 - 0.065 12.8 0.6 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 Putative amidoligase enzyme SEFIR PF08357.6 ESA01946.1 - 0.093 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 SEFIR domain EF1G PF00647.14 ESA01951.1 - 0.018 14.7 0.1 0.032 13.9 0.0 1.3 1 1 0 1 1 1 0 Elongation factor 1 gamma, conserved domain F-box-like PF12937.2 ESA01954.1 - 1.1e-05 25.0 0.1 2.9e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box-like_2 PF13013.1 ESA01954.1 - 0.045 13.4 0.3 0.091 12.4 0.2 1.7 1 1 0 1 1 1 0 F-box-like domain DUF2924 PF11149.3 ESA01955.1 - 0.063 13.2 1.0 0.092 12.7 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2924) Mst1_SARAH PF11629.3 ESA01955.1 - 9.8 6.0 8.5 0.84 9.5 2.2 2.1 2 1 0 2 2 2 0 C terminal SARAH domain of Mst1 BCNT PF07572.7 ESA01956.1 - 0.004 17.0 0.2 0.0056 16.5 0.1 1.3 1 0 0 1 1 1 1 Bucentaur or craniofacial development MtrA PF04208.9 ESA01956.1 - 0.0053 16.2 0.1 0.006 16.0 0.1 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A Tropomyosin PF00261.15 ESA01956.1 - 0.019 14.0 0.1 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Tropomyosin Streptin-Immun PF11083.3 ESA01956.1 - 0.036 14.0 0.3 0.05 13.5 0.2 1.4 1 1 0 1 1 1 0 Lantibiotic streptin immunity protein Pox_polyA_pol_N PF12630.2 ESA01956.1 - 0.25 11.4 1.0 1.5 8.9 0.5 2.0 1 1 1 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain BTB PF00651.26 ESA01957.1 - 2.1e-17 63.1 1.3 1.9e-16 59.9 0.1 2.6 2 1 1 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA01957.1 - 5.8e-08 32.8 4.5 1.1e-07 31.9 2.2 2.3 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA01957.1 - 6.2e-06 25.9 3.6 0.0021 17.8 0.2 3.8 2 1 2 4 4 4 2 BTB And C-terminal Kelch BTB PF00651.26 ESA01959.1 - 4.8e-14 52.2 0.2 1.1e-13 51.1 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA01959.1 - 1.1e-08 34.7 0.5 3.1e-07 30.1 0.2 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA01959.1 - 4.3e-05 23.5 4.4 0.00038 20.4 0.0 3.0 3 1 0 3 3 3 1 TLD Collagen PF01391.13 ESA01959.1 - 0.05 13.1 3.4 0.075 12.5 2.4 1.1 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) TFIIA PF03153.8 ESA01959.1 - 3.3 7.5 11.5 3.7 7.3 8.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NUDIX PF00293.23 ESA01960.1 - 9.8e-10 38.1 0.0 1.9e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain zf-CCHC PF00098.18 ESA01960.1 - 0.014 15.2 1.1 0.025 14.4 0.8 1.4 1 0 0 1 1 1 0 Zinc knuckle TLD PF07534.11 ESA01963.1 - 0.024 14.6 0.0 0.048 13.6 0.0 1.6 1 0 0 1 1 1 0 TLD BTB PF00651.26 ESA01964.1 - 1.5e-17 63.6 0.1 3.7e-17 62.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain RicinB_lectin_2 PF14200.1 ESA01964.1 - 1.4e-12 47.8 0.6 3.8e-09 36.8 0.0 3.5 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like TLD PF07534.11 ESA01964.1 - 6.9e-12 45.5 2.0 6.9e-12 45.5 1.4 2.0 2 0 0 2 2 2 1 TLD Ricin_B_lectin PF00652.17 ESA01964.1 - 8e-10 38.8 1.1 0.00076 19.5 0.1 3.2 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain BACK PF07707.10 ESA01964.1 - 1.6e-07 31.0 0.4 3.9e-06 26.6 0.1 3.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch PGG PF13962.1 ESA01966.1 - 5.4 6.6 9.5 1.7 8.2 3.2 2.2 2 0 0 2 2 2 0 Domain of unknown function FAR1 PF03101.10 ESA01967.1 - 7.1e-08 32.8 0.2 1.2e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Rad33 PF08730.5 ESA01968.1 - 2.4e-05 23.8 0.9 5.4e-05 22.7 0.7 1.6 1 1 0 1 1 1 1 Rad33 zf-CCHC_4 PF14392.1 ESA01968.1 - 0.0008 19.0 0.2 0.0026 17.3 0.2 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA01968.1 - 0.14 11.7 0.6 0.29 10.6 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 ESA01968.1 - 0.14 12.1 2.3 0.26 11.3 1.6 1.5 1 0 0 1 1 1 0 Zinc knuckle BTB PF00651.26 ESA01970.1 - 4.7e-21 74.8 0.1 6.1e-21 74.4 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain UvrD-helicase PF00580.16 ESA01972.1 - 1.8 7.8 6.0 1.4 8.1 1.7 2.2 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain ADPrib_exo_Tox PF03496.9 ESA01973.1 - 0.0044 16.2 0.6 0.0059 15.8 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme DUF1599 PF07659.6 ESA01973.1 - 0.0056 16.7 0.3 0.016 15.2 0.2 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1599) DUF3958 PF13125.1 ESA01974.1 - 0.081 12.8 0.6 0.21 11.4 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) Pkinase_Tyr PF07714.12 ESA01977.1 - 1.6e-05 24.1 0.0 3.7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA01977.1 - 0.015 14.4 0.0 0.056 12.5 0.0 1.9 1 1 1 2 2 2 0 Protein kinase domain Cu-binding_MopE PF11617.3 ESA01977.1 - 0.033 13.9 0.1 0.089 12.5 0.0 1.8 1 0 0 1 1 1 0 Protein metal binding site Glyco_transf_4 PF13439.1 ESA01977.1 - 0.064 12.9 0.0 0.08 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase Family 4 SYCE1 PF15233.1 ESA01977.1 - 0.32 10.9 3.1 0.79 9.6 2.2 1.5 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 RdRP PF05183.7 ESA01979.1 - 3.9e-186 620.1 0.1 5e-186 619.8 0.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase PXA PF02194.10 ESA01980.1 - 1e-25 90.3 3.3 5.2e-25 88.0 2.3 2.3 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.7 ESA01980.1 - 3.7e-15 55.9 0.2 3.7e-15 55.9 0.1 3.4 4 0 0 4 4 4 1 Sorting nexin C terminal RGS PF00615.14 ESA01980.1 - 5e-15 55.6 3.5 2.6e-14 53.3 0.8 3.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain PX PF00787.19 ESA01980.1 - 5.9e-08 32.4 0.0 2e-07 30.8 0.0 2.0 1 0 0 1 1 1 1 PX domain Myosin_head PF00063.16 ESA01981.1 - 5.3e-260 864.2 0.9 5.3e-260 864.2 0.6 2.5 3 1 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.14 ESA01981.1 - 1.6e-27 95.6 122.8 2.1e-19 68.8 28.4 3.1 1 1 2 3 3 3 2 Myosin tail Myosin_N PF02736.14 ESA01981.1 - 1.2e-08 34.4 2.5 4.2e-08 32.7 1.7 2.0 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.22 ESA01981.1 - 0.0072 15.8 6.3 0.04 13.5 0.0 3.0 3 0 0 3 3 3 1 IQ calmodulin-binding motif Reo_sigmaC PF04582.7 ESA01981.1 - 0.021 14.0 30.1 0.22 10.6 0.9 4.1 1 1 2 4 4 4 0 Reovirus sigma C capsid protein PDZ_1 PF12812.2 ESA01981.1 - 0.071 13.0 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 PDZ-like domain AAA_16 PF13191.1 ESA01981.1 - 0.097 12.6 0.0 0.097 12.6 0.0 4.4 2 1 1 4 4 4 0 AAA ATPase domain AAA_19 PF13245.1 ESA01981.1 - 0.16 11.7 0.0 0.43 10.3 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 ESA01981.1 - 0.47 10.6 0.0 0.47 10.6 0.0 4.0 4 1 1 5 5 5 0 AAA domain FUSC PF04632.7 ESA01981.1 - 5.8 5.2 8.7 1.4 7.2 3.5 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family PSP1 PF04468.7 ESA01982.1 - 3.4e-36 123.0 1.8 5.6e-36 122.4 1.2 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region DUF576 PF04507.7 ESA01983.1 - 0.18 10.7 1.2 0.26 10.1 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF576 NT-C2 PF10358.4 ESA01984.1 - 2.6e-26 91.8 3.1 3.7e-26 91.3 2.2 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins UQ_con PF00179.21 ESA01985.1 - 5e-44 149.1 0.0 5.8e-44 148.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.6 ESA01985.1 - 0.015 14.8 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.17 ESA01985.1 - 0.046 13.6 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 RWD domain Nfu_N PF08712.6 ESA01986.1 - 4.9e-29 99.7 0.0 1.2e-28 98.5 0.0 1.7 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 ESA01986.1 - 2.9e-22 78.2 0.2 4.8e-22 77.5 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain DUF3685 PF12452.3 ESA01986.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) MFS_1 PF07690.11 ESA01987.1 - 5.4e-18 64.8 21.6 5.4e-18 64.8 15.0 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily PPP4R2 PF09184.6 ESA01988.1 - 1.9e-17 63.7 26.5 1.9e-17 63.7 18.4 3.3 1 1 2 3 3 3 1 PPP4R2 DUF2407 PF10302.4 ESA01988.1 - 0.089 12.9 0.1 0.089 12.9 0.1 2.9 2 1 0 2 2 2 0 DUF2407 ubiquitin-like domain Mg_trans_NIPA PF05653.9 ESA01989.1 - 1.3e-63 214.7 23.0 2.6e-60 203.9 12.9 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA01989.1 - 1e-06 28.9 0.6 1e-06 28.9 0.4 3.6 3 1 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA01989.1 - 1.1e-06 28.7 3.3 1.1e-06 28.7 2.3 4.8 3 1 0 3 3 3 1 EamA-like transporter family MFS_1 PF07690.11 ESA01989.1 - 5.4 5.6 24.8 1.1 7.9 12.2 2.6 1 1 1 2 2 2 0 Major Facilitator Superfamily DUF3185 PF11381.3 ESA01989.1 - 6.4 6.6 9.9 3.6 7.4 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3185) DUF2663 PF10864.3 ESA01989.1 - 8 6.6 9.0 1.7 8.8 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) CASP_C PF08172.7 ESA01990.1 - 0.059 12.3 0.5 0.06 12.3 0.3 1.0 1 0 0 1 1 1 0 CASP C terminal Ribosomal_L16 PF00252.13 ESA01991.1 - 4e-33 114.0 0.1 4.9e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RTBV_P46 PF06216.6 ESA01991.1 - 0.075 11.8 0.1 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein FAM75 PF14650.1 ESA01992.1 - 0.021 14.2 0.2 0.028 13.8 0.1 1.1 1 0 0 1 1 1 0 FAM75 family WD40 PF00400.27 ESA01993.1 - 1.6e-50 167.2 24.3 3.2e-10 39.4 0.4 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA01993.1 - 2.8e-13 48.8 13.7 0.00082 17.6 0.0 5.0 2 2 1 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA01993.1 - 6.7e-06 25.1 6.5 0.77 8.4 0.4 4.3 2 2 1 3 3 3 3 Nup133 N terminal like CENP-F_leu_zip PF10473.4 ESA01993.1 - 0.0019 18.0 2.3 0.0029 17.4 1.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nsp1_C PF05064.8 ESA01993.1 - 0.068 12.8 1.1 0.3 10.7 0.6 2.1 2 0 0 2 2 2 0 Nsp1-like C-terminal region TBPIP PF07106.8 ESA01993.1 - 0.17 11.4 1.6 0.27 10.7 1.1 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) LRR_8 PF13855.1 ESA01994.1 - 0.011 15.5 6.7 0.063 13.0 0.6 3.4 3 1 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.2 ESA01994.1 - 0.055 13.1 8.1 0.23 11.1 0.3 4.0 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) PAH PF02671.16 ESA01994.1 - 0.062 12.9 0.1 1.6 8.4 0.0 2.6 2 0 0 2 2 2 0 Paired amphipathic helix repeat LRR_1 PF00560.28 ESA01994.1 - 0.17 12.0 5.0 36 4.9 0.2 4.8 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 ESA01994.1 - 1.4 9.4 6.0 1.6e+02 3.2 0.0 5.3 6 0 0 6 6 6 0 Leucine rich repeat Apc4 PF12896.2 ESA01995.1 - 1.5e-39 135.4 4.6 5.5e-39 133.6 3.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 Apc4_WD40 PF12894.2 ESA01995.1 - 3.3e-11 42.5 0.1 1.6e-09 37.1 0.2 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 ESA01996.1 - 7.4e-37 123.9 4.2 2.8e-10 39.6 0.0 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat LisH PF08513.6 ESA01996.1 - 0.0048 16.6 0.1 0.0097 15.6 0.0 1.6 1 0 0 1 1 1 1 LisH Apc4_WD40 PF12894.2 ESA01996.1 - 0.017 14.5 1.0 6.8 6.2 0.0 4.3 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1546 PF07571.8 ESA01997.1 - 5.9e-32 109.6 0.1 5.2e-30 103.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1546) TAF PF02969.12 ESA01997.1 - 9.7e-28 95.9 0.0 2.2e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 ESA01997.1 - 1.3e-05 25.1 0.2 2.5e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.10 ESA01997.1 - 0.02 14.6 0.0 0.053 13.2 0.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.18 ESA01997.1 - 0.039 14.0 0.7 0.098 12.7 0.1 2.0 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HEAT_2 PF13646.1 ESA01997.1 - 0.11 12.8 0.0 1.9 8.8 0.0 2.9 2 1 0 2 2 2 0 HEAT repeats TMV_coat PF00721.16 ESA01998.1 - 0.067 13.1 2.3 0.09 12.7 1.6 1.1 1 0 0 1 1 1 0 Virus coat protein (TMV like) Mitofilin PF09731.4 ESA01999.1 - 3.4e-85 286.8 19.8 4.2e-85 286.5 13.7 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein HHH_5 PF14520.1 ESA01999.1 - 0.04 14.0 0.2 0.28 11.3 0.1 2.4 1 1 0 1 1 1 0 Helix-hairpin-helix domain HBS1_N PF08938.5 ESA01999.1 - 0.095 12.8 3.7 0.28 11.3 2.5 1.8 1 0 0 1 1 1 0 HBS1 N-terminus Borrelia_lipo_2 PF06238.6 ESA01999.1 - 0.24 11.4 4.6 1.6 8.8 0.0 3.2 3 1 1 4 4 4 0 Borrelia burgdorferi BBR25 lipoprotein RE_AlwI PF09491.5 ESA01999.1 - 0.84 8.0 10.6 0.93 7.8 5.7 2.0 2 0 0 2 2 2 0 AlwI restriction endonuclease Perilipin PF03036.11 ESA01999.1 - 1.6 7.4 10.8 0.76 8.5 5.4 1.8 1 1 1 2 2 2 0 Perilipin family GBP_C PF02841.9 ESA01999.1 - 5.6 6.0 17.5 8.9 5.3 12.1 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF4375 PF14300.1 ESA02000.1 - 0.065 13.2 1.8 0.18 11.7 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) XRN_N PF03159.13 ESA02001.1 - 1.3e-113 378.2 0.0 1.5e-113 378.0 0.0 1.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.18 ESA02001.1 - 9.2e-05 22.1 1.9 0.00016 21.4 1.3 1.4 1 0 0 1 1 1 1 Zinc knuckle BTB PF00651.26 ESA02002.1 - 3.3e-13 49.6 0.0 6.6e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02002.1 - 3.2e-08 33.6 3.1 6.3e-08 32.6 0.5 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02002.1 - 1.8e-06 27.7 0.4 2.8e-05 23.8 0.0 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch RasGEF_N PF00618.15 ESA02002.1 - 0.015 15.3 0.8 0.015 15.3 0.6 2.7 2 1 0 2 2 2 0 RasGEF N-terminal motif ETRAMP PF09716.5 ESA02002.1 - 0.94 9.4 5.2 1.4 8.9 0.6 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.20 ESA02003.1 - 1.5e-17 63.5 3.1 5.2e-17 61.8 2.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02003.1 - 1e-15 57.5 0.1 4.3e-12 45.6 0.0 2.0 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA02003.1 - 0.25 11.0 0.4 0.4 10.3 0.3 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TetR_C_8 PF14278.1 ESA02004.1 - 0.092 13.1 0.4 0.52 10.7 0.1 2.1 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region Tox-WTIP PF15654.1 ESA02005.1 - 5.4 6.7 6.7 16 5.1 3.0 2.2 1 1 1 2 2 2 0 Toxin with a conserved tryptophan and TIP tripeptide motif Toxin_65 PF15543.1 ESA02006.1 - 0.075 12.6 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative toxin 65 DUF4027 PF13219.1 ESA02010.1 - 0.029 13.7 0.0 0.063 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4027) Baculo_gp41 PF04700.7 ESA02011.1 - 0.47 9.8 4.3 3 7.2 3.0 1.9 1 1 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region MSV199 PF10553.4 ESA02011.1 - 2.9 7.7 7.4 13 5.6 0.2 2.1 1 1 1 2 2 2 0 MSV199 domain Helicase_C PF00271.26 ESA02012.1 - 1.5e-15 56.7 0.0 9.9e-15 54.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.1 ESA02012.1 - 0.1 12.7 0.0 0.1 12.7 0.0 3.1 3 0 0 3 3 3 0 Snf2-ATP coupling, chromatin remodelling complex Iso_dh PF00180.15 ESA02013.1 - 2.3e-77 260.3 0.0 2.7e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ThiF PF00899.16 ESA02015.1 - 2.2e-49 166.7 0.1 4e-30 104.3 0.0 2.5 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 ESA02015.1 - 7.5e-47 158.5 0.2 5.7e-46 155.7 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 ESA02015.1 - 1.6e-43 146.0 0.6 9.7e-28 95.5 0.1 2.7 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESA02015.1 - 4.4e-27 93.1 0.9 1.1e-22 79.0 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site DUF1002 PF06207.6 ESA02015.1 - 0.057 12.7 0.1 0.15 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) HALZ PF02183.13 ESA02016.1 - 0.0016 18.1 15.2 0.0034 17.0 4.3 3.7 2 2 0 2 2 2 1 Homeobox associated leucine zipper Atg14 PF10186.4 ESA02016.1 - 0.0017 17.3 7.7 0.0017 17.3 5.3 2.4 1 1 1 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 KIAA1430 PF13879.1 ESA02016.1 - 0.0045 17.3 3.9 0.0045 17.3 2.7 2.4 2 0 0 2 2 2 1 KIAA1430 homologue DUF972 PF06156.8 ESA02016.1 - 0.005 17.1 27.5 0.013 15.8 5.2 3.4 1 1 2 3 3 3 2 Protein of unknown function (DUF972) AAA_13 PF13166.1 ESA02016.1 - 0.0075 14.7 28.9 0.0099 14.3 20.0 1.0 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 ESA02016.1 - 0.0095 15.5 37.7 0.069 12.7 8.5 3.0 1 1 2 3 3 3 2 IncA protein Filament PF00038.16 ESA02016.1 - 0.022 14.2 30.7 1.6 8.1 9.9 3.0 1 1 1 2 2 2 0 Intermediate filament protein CALCOCO1 PF07888.6 ESA02016.1 - 0.023 13.0 28.7 0.2 9.9 9.0 2.4 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3450 PF11932.3 ESA02016.1 - 0.025 13.8 22.1 0.022 14.0 4.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF904 PF06005.7 ESA02016.1 - 0.028 14.7 10.9 0.028 14.7 7.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF904) BLOC1_2 PF10046.4 ESA02016.1 - 0.044 13.9 21.2 0.4 10.8 1.6 3.5 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Shugoshin_N PF07558.6 ESA02016.1 - 0.19 11.4 11.9 0.098 12.3 3.6 2.9 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region ATG16 PF08614.6 ESA02016.1 - 0.26 11.0 32.8 3.9 7.2 5.7 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.2 ESA02016.1 - 0.99 8.6 35.8 0.95 8.7 2.0 3.1 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain HAP1_N PF04849.8 ESA02016.1 - 1.5 7.7 33.6 0.026 13.4 3.3 2.8 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DivIC PF04977.10 ESA02016.1 - 1.6 8.2 35.0 0.76 9.3 4.2 4.9 2 2 3 5 5 5 0 Septum formation initiator bZIP_1 PF00170.16 ESA02016.1 - 2.4 8.1 33.9 0.12 12.3 3.8 5.7 2 2 4 6 6 6 0 bZIP transcription factor DUF4140 PF13600.1 ESA02016.1 - 3.3 8.2 19.4 2.2 8.7 2.0 3.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) GrpE PF01025.14 ESA02016.1 - 4.4 6.8 29.1 2.5 7.6 8.1 2.8 2 1 1 3 3 3 0 GrpE Prominin PF05478.6 ESA02016.1 - 4.7 4.6 14.0 0.047 11.2 0.5 2.1 1 1 1 2 2 2 0 Prominin DUF812 PF05667.6 ESA02016.1 - 5.3 5.4 29.9 4.1 5.8 8.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) TSC22 PF01166.13 ESA02016.1 - 5.8 6.9 24.0 0.33 10.9 2.9 4.4 3 2 2 5 5 5 0 TSC-22/dip/bun family SurA_N_2 PF13623.1 ESA02016.1 - 5.9 6.8 9.3 0.4 10.6 2.0 2.0 2 0 0 2 2 2 0 SurA N-terminal domain DUF3552 PF12072.3 ESA02016.1 - 8.7 5.5 32.8 1.8 7.7 8.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) Peptidase_C97 PF05903.9 ESA02017.1 - 0.0075 16.0 1.0 0.061 13.0 0.7 2.1 1 1 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.8 ESA02017.1 - 0.057 13.3 0.2 0.17 11.8 0.1 1.8 2 0 0 2 2 2 0 Lecithin retinol acyltransferase Secretin_N_2 PF07655.8 ESA02017.1 - 2.2 8.7 14.5 3.4 8.1 10.0 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Pkinase_Tyr PF07714.12 ESA02018.1 - 1.4e-28 99.6 0.0 2.9e-27 95.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02018.1 - 1.8e-24 86.3 0.0 2e-23 82.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain DUF4211 PF13926.1 ESA02018.1 - 0.0044 16.4 0.2 0.012 14.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) eIF-5_eIF-2B PF01873.12 ESA02018.1 - 0.13 11.8 1.2 0.77 9.4 0.1 2.7 3 0 0 3 3 3 0 Domain found in IF2B/IF5 DUF3192 PF11399.3 ESA02019.1 - 0.085 12.7 0.1 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) GDI PF00996.13 ESA02021.1 - 3.2e-97 325.6 0.0 3.5e-97 325.5 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.1 ESA02021.1 - 0.14 12.2 0.1 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DNA_repr_REX1B PF14966.1 ESA02023.1 - 0.0027 18.0 6.9 0.027 14.8 0.8 2.7 2 1 1 3 3 3 2 DNA repair REX1-B Laminin_I PF06008.9 ESA02023.1 - 0.0033 16.7 0.2 0.0058 15.9 0.1 1.3 1 0 0 1 1 1 1 Laminin Domain I NPV_P10 PF05531.7 ESA02023.1 - 0.0074 16.5 6.2 0.39 10.9 0.9 2.6 1 1 1 2 2 2 2 Nucleopolyhedrovirus P10 protein Med2 PF11214.3 ESA02023.1 - 0.0084 16.1 7.4 0.17 11.9 0.3 2.5 1 1 1 2 2 2 2 Mediator complex subunit 2 MCPsignal PF00015.16 ESA02023.1 - 0.042 13.3 8.9 0.065 12.7 6.2 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Mating_N PF12731.2 ESA02023.1 - 0.12 12.2 5.1 2.7 7.9 1.1 2.7 1 1 1 2 2 2 0 Mating-type protein beta 1 DUF148 PF02520.12 ESA02023.1 - 0.16 11.7 7.1 0.64 9.8 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 NAD_binding_2 PF03446.10 ESA02023.1 - 0.75 9.6 3.3 9.8 5.9 0.2 2.2 1 1 1 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase TPR_MLP1_2 PF07926.7 ESA02023.1 - 0.93 9.2 6.1 0.78 9.4 2.1 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 ESA02023.1 - 1 9.1 6.3 2.5 7.9 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Pkinase_Tyr PF07714.12 ESA02024.1 - 1.6e-28 99.5 0.1 2.5e-28 98.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02024.1 - 4.7e-23 81.6 0.2 7.7e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA02024.1 - 0.012 16.1 0.1 0.032 14.8 0.1 1.7 1 0 0 1 1 1 0 Sel1 repeat Kinase-like PF14531.1 ESA02024.1 - 0.031 13.2 0.0 0.051 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like OKR_DC_1_N PF03709.10 ESA02025.1 - 0.02 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain LDB19 PF13002.2 ESA02026.1 - 0.073 12.5 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Arrestin_N terminal like DUF1870 PF08965.5 ESA02028.1 - 0.035 13.7 0.3 0.037 13.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) zf-DBF PF07535.7 ESA02028.1 - 0.15 11.7 0.4 0.21 11.2 0.3 1.2 1 0 0 1 1 1 0 DBF zinc finger zf-CCHC PF00098.18 ESA02029.1 - 3.7e-10 39.2 12.2 4.6e-07 29.4 1.7 2.8 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_4 PF14392.1 ESA02029.1 - 1.2e-05 24.8 6.9 0.018 14.7 0.6 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 ESA02029.1 - 0.0012 18.4 6.4 0.18 11.5 0.0 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.1 ESA02029.1 - 0.0067 15.8 2.6 0.34 10.4 0.1 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.1 ESA02029.1 - 0.029 13.8 6.9 0.25 10.8 0.5 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-C2HC_2 PF13913.1 ESA02029.1 - 0.25 11.0 5.3 2.4 7.9 0.3 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-HC5HC2H PF13771.1 ESA02029.1 - 0.65 10.1 10.6 2.2 8.5 3.2 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain PHD PF00628.24 ESA02029.1 - 0.81 9.4 5.5 16 5.2 3.7 2.3 1 1 1 2 2 2 0 PHD-finger zf-CCHC_6 PF15288.1 ESA02029.1 - 0.87 9.3 7.7 1 9.0 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle Crust_neurohorm PF01147.12 ESA02029.1 - 6 6.2 10.7 0.45 9.8 0.6 2.2 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family Zn_Tnp_IS91 PF14319.1 ESA02029.1 - 6.3 6.3 13.2 1.7 8.2 2.9 2.1 1 1 1 2 2 2 0 Transposase zinc-binding domain Abhydrolase_3 PF07859.8 ESA02030.1 - 4.3e-16 59.1 0.1 2e-08 34.0 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA02030.1 - 0.00065 19.4 0.0 0.00086 19.0 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA02030.1 - 0.0019 17.6 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.7 ESA02030.1 - 0.1 11.0 0.1 0.17 10.3 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) BTB PF00651.26 ESA02031.1 - 1.4e-18 66.8 0.2 2.9e-18 65.8 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02031.1 - 1.7e-11 44.2 1.4 3.2e-11 43.3 1.0 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02031.1 - 8.6e-07 28.7 1.4 0.0001 22.0 0.4 3.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch Snf7 PF03357.16 ESA02033.1 - 0.047 13.0 0.2 0.099 12.0 0.2 1.5 1 0 0 1 1 1 0 Snf7 DUF4508 PF14969.1 ESA02033.1 - 0.088 12.8 0.1 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF1312 PF07009.6 ESA02034.1 - 0.017 14.9 0.3 0.024 14.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1312) F-box-like PF12937.2 ESA02035.1 - 0.00015 21.4 5.4 0.00029 20.4 2.8 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA02035.1 - 0.33 10.6 6.0 0.33 10.6 2.1 2.8 2 0 0 2 2 2 0 F-box domain DUF1394 PF07159.7 ESA02036.1 - 4.6e-97 324.7 0.4 5.3e-97 324.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) NIF PF03031.13 ESA02037.1 - 4.1e-58 195.5 0.1 5.5e-58 195.1 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase T4-Gluco-transf PF09198.5 ESA02038.1 - 0.18 11.1 0.1 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase HATPase_c PF02518.21 ESA02039.1 - 1.1e-06 28.3 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 ESA02039.1 - 6.5e-06 26.1 0.1 0.00029 20.8 0.0 3.0 2 1 0 2 2 2 1 Response regulator receiver domain HTH_Tnp_Tc5 PF03221.11 ESA02039.1 - 0.0095 15.7 0.1 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CbiC PF02570.10 ESA02039.1 - 0.13 11.6 0.1 4.6 6.5 0.0 2.4 3 0 0 3 3 3 0 Precorrin-8X methylmutase ATP-synt_ab PF00006.20 ESA02041.1 - 2.2e-63 213.6 0.0 3.3e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESA02041.1 - 1.1e-25 90.3 0.6 1.8e-25 89.5 0.4 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESA02041.1 - 1.5e-23 82.7 3.1 3.3e-23 81.6 2.1 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Arch_ATPase PF01637.13 ESA02041.1 - 0.0013 18.4 0.0 0.0036 17.0 0.0 1.6 2 0 0 2 2 2 1 Archaeal ATPase NB-ARC PF00931.17 ESA02041.1 - 0.0043 15.9 1.8 0.022 13.6 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain MobB PF03205.9 ESA02041.1 - 0.0046 16.6 1.2 0.51 10.0 0.0 3.2 4 0 0 4 4 4 1 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 ESA02041.1 - 0.007 16.5 0.1 0.29 11.3 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA02041.1 - 0.0078 16.2 0.0 0.021 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 ESA02041.1 - 0.0083 15.8 0.1 0.027 14.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain KaiC PF06745.8 ESA02041.1 - 0.013 14.5 0.1 0.022 13.8 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.1 ESA02041.1 - 0.026 14.6 0.0 0.078 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESA02041.1 - 0.032 13.4 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 ESA02041.1 - 0.035 13.5 0.1 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESA02041.1 - 0.095 12.8 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase WD40 PF00400.27 ESA02042.1 - 3.4e-63 207.4 19.5 1.3e-09 37.6 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA02042.1 - 6e-15 54.3 6.2 0.0015 16.7 0.0 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA02042.1 - 8e-05 21.5 2.5 0.02 13.6 0.1 4.0 2 2 1 3 3 3 1 Nup133 N terminal like eIF2A PF08662.6 ESA02042.1 - 0.00049 19.8 0.1 0.26 10.9 0.1 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.1 ESA02042.1 - 0.0019 17.6 1.7 0.19 11.1 0.4 3.5 2 2 1 3 3 3 1 PQQ-like domain DUF1513 PF07433.6 ESA02042.1 - 0.0047 15.8 0.0 1.8 7.3 0.0 2.8 1 1 2 3 3 3 2 Protein of unknown function (DUF1513) STE PF02200.11 ESA02042.1 - 0.048 13.8 0.2 2.1 8.5 0.0 3.0 2 1 1 3 3 3 0 STE like transcription factor F-box-like PF12937.2 ESA02042.1 - 0.084 12.6 0.2 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 F-box-like NPCBM PF08305.6 ESA02043.1 - 0.0097 15.8 0.2 0.089 12.7 0.0 2.2 1 1 1 2 2 2 1 NPCBM/NEW2 domain DUF4094 PF13334.1 ESA02043.1 - 0.053 13.9 0.8 0.053 13.9 0.6 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4094) DUF2576 PF10845.3 ESA02043.1 - 0.089 11.9 1.3 0.55 9.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) Cast PF10174.4 ESA02043.1 - 0.095 10.7 44.5 0.03 12.4 27.6 1.9 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone Filament PF00038.16 ESA02043.1 - 0.4 10.1 39.7 0.99 8.8 0.8 3.5 1 1 1 3 3 3 0 Intermediate filament protein DDE_Tnp_1_2 PF13586.1 ESA02043.1 - 0.5 10.5 5.1 0.89 9.7 0.2 3.1 4 0 0 4 4 4 0 Transposase DDE domain Reo_sigmaC PF04582.7 ESA02043.1 - 0.74 8.9 15.5 0.78 8.8 0.4 3.0 1 1 1 3 3 3 0 Reovirus sigma C capsid protein Phage_lysis PF03245.8 ESA02043.1 - 3 7.8 17.8 0.12 12.3 1.4 3.6 1 1 2 3 3 3 0 Bacteriophage Rz lysis protein DUF4407 PF14362.1 ESA02043.1 - 3.9 6.3 19.3 18 4.1 4.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Vir_act_alpha_C PF10400.4 ESA02043.1 - 5.2 7.5 17.0 6.8 7.1 0.2 4.7 2 1 4 6 6 6 0 Virulence activator alpha C-term WEMBL PF05701.6 ESA02043.1 - 6.5 5.0 44.1 3.8 5.8 18.3 2.4 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Autophagy_N PF03986.8 ESA02044.1 - 8.4e-48 161.8 0.7 1.4e-47 161.1 0.5 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 ESA02044.1 - 5.8e-29 100.0 0.7 1.8e-28 98.5 0.5 1.9 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 ESA02044.1 - 3e-14 51.7 3.4 5.5e-14 50.9 2.3 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal ArdA PF07275.6 ESA02044.1 - 0.015 15.5 0.5 0.015 15.5 0.4 1.8 2 1 0 2 2 2 0 Antirestriction protein (ArdA) Dynamin_N PF00350.18 ESA02044.1 - 0.048 13.4 0.3 0.048 13.4 0.2 1.5 2 0 0 2 2 2 0 Dynamin family DUF1772 PF08592.6 ESA02044.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) HATPase_c PF02518.21 ESA02045.1 - 1.3e-24 86.0 0.1 2.8e-24 84.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 ESA02045.1 - 3.5e-16 58.9 0.1 1.1e-15 57.3 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.19 ESA02045.1 - 1.3e-09 38.0 0.0 3.2e-05 23.8 0.0 3.3 3 0 0 3 3 3 2 Response regulator receiver domain Methyltransf_11 PF08241.7 ESA02046.1 - 5.1e-17 62.1 0.0 7.7e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA02046.1 - 7.8e-11 41.7 0.0 1e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA02046.1 - 3.2e-10 39.9 0.0 4e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA02046.1 - 4.8e-10 39.6 0.0 9.1e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA02046.1 - 1.7e-09 37.1 0.0 4e-09 35.9 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA02046.1 - 5.9e-08 33.1 0.0 9e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA02046.1 - 9.4e-07 29.4 0.0 1.8e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 ESA02046.1 - 6.8e-05 21.8 0.0 7.2e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_26 PF13659.1 ESA02046.1 - 0.00082 19.3 0.0 0.0039 17.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA02046.1 - 0.0011 18.3 0.0 0.0039 16.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.5 ESA02046.1 - 0.0016 17.9 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.10 ESA02046.1 - 0.012 15.0 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_8 PF05148.10 ESA02046.1 - 0.014 15.0 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase RrnaAD PF00398.15 ESA02046.1 - 0.051 12.6 0.0 0.088 11.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF2247 PF10004.4 ESA02046.1 - 0.056 13.1 0.2 0.088 12.5 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) NodS PF05401.6 ESA02046.1 - 0.061 12.7 0.0 0.078 12.3 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF1604 PF07713.8 ESA02047.1 - 3.7e-37 125.9 2.2 3.7e-37 125.9 1.5 4.1 3 1 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.18 ESA02047.1 - 9.8e-07 28.4 0.1 3.7e-06 26.6 0.1 2.0 1 0 0 1 1 1 1 G-patch domain DUF4519 PF15012.1 ESA02047.1 - 5.9 6.8 6.8 2.4 8.1 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Utp14 PF04615.8 ESA02048.1 - 7.3e-183 609.6 66.8 1.3e-182 608.8 46.3 1.3 1 1 0 1 1 1 1 Utp14 protein Cytadhesin_P30 PF07271.6 ESA02048.1 - 0.12 11.6 3.4 0.2 10.8 0.3 2.5 2 0 0 2 2 2 0 Cytadhesin P30/P32 GCR1_C PF12550.3 ESA02049.1 - 0.037 13.8 2.4 0.096 12.5 1.7 1.8 1 1 0 1 1 1 0 Transcriptional activator of glycolytic enzymes Orthopox_B11R PF07033.6 ESA02053.1 - 6.5 6.3 8.2 2.4 7.6 2.5 2.2 2 0 0 2 2 2 0 Orthopoxvirus B11R protein Herpes_ori_bp PF02399.10 ESA02055.1 - 2.4e-15 55.6 0.2 4.5e-15 54.7 0.0 1.4 2 0 0 2 2 2 1 Origin of replication binding protein Pkinase PF00069.20 ESA02056.1 - 6.6e-24 84.4 0.9 6.7e-13 48.3 0.5 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02056.1 - 9.9e-20 70.6 0.3 2.4e-10 39.9 0.1 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Plug PF07715.10 ESA02056.1 - 0.08 13.2 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 TonB-dependent Receptor Plug Domain WD40 PF00400.27 ESA02057.1 - 2.8e-16 58.6 0.8 7.1e-08 32.0 0.1 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESA02057.1 - 0.022 14.5 0.0 0.53 10.0 0.0 2.9 2 2 2 4 4 4 0 Ciliary BBSome complex subunit 2, middle region DC_STAMP PF07782.8 ESA02057.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 DC-STAMP-like protein Chloroplast_duf PF14476.1 ESA02059.1 - 0.11 11.2 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 Petal formation-expressed Sel1 PF08238.7 ESA02064.1 - 1.1e-18 67.2 8.1 9.5e-09 35.6 0.0 3.5 3 0 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ESA02064.1 - 0.013 15.9 4.4 2.3 8.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA02064.1 - 0.013 16.1 0.0 0.32 11.7 0.0 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA02064.1 - 0.19 11.5 8.8 5.6 6.9 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA02064.1 - 1.2 8.8 5.5 3.3 7.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA02064.1 - 1.3 9.0 9.2 1.7 8.7 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA02064.1 - 2.5 7.8 5.6 2.6 7.7 1.5 2.6 2 1 0 2 2 2 0 TPR repeat Tub PF01167.13 ESA02066.1 - 3.9e-20 71.8 0.0 2.7e-14 52.7 0.0 2.2 1 1 1 2 2 2 2 Tub family GCOM2 PF15328.1 ESA02066.1 - 0.03 14.0 0.1 0.036 13.8 0.1 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 CALCOCO1 PF07888.6 ESA02066.1 - 0.099 10.9 0.4 0.13 10.5 0.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Peptidase_S9 PF00326.16 ESA02067.1 - 3.3e-07 29.7 0.0 7.2e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 ESA02067.1 - 4.2e-06 26.5 0.0 8.3e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 ESA02067.1 - 0.079 12.3 0.0 1.8 7.9 0.0 2.1 2 0 0 2 2 2 0 Putative esterase Tannase PF07519.6 ESA02067.1 - 0.2 10.3 0.0 0.32 9.6 0.0 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase Abhydrolase_6 PF12697.2 ESA02067.1 - 0.27 11.0 0.0 1.2 8.9 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family HMG_box PF00505.14 ESA02068.1 - 0.00026 21.1 1.8 0.00063 19.9 1.2 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA02068.1 - 0.0021 18.3 1.1 0.0038 17.5 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain DUF1074 PF06382.6 ESA02068.1 - 0.018 15.0 0.3 0.022 14.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1074) PRANC PF09372.5 ESA02068.1 - 0.066 13.1 0.4 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 PRANC domain RestrictionSfiI PF11487.3 ESA02068.1 - 0.11 11.6 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Type II restriction enzyme SfiI MAT_Alpha1 PF04769.7 ESA02068.1 - 0.17 11.1 2.1 0.2 10.9 1.1 1.4 1 1 0 1 1 1 0 Mating-type protein MAT alpha 1 Sel1 PF08238.7 ESA02069.1 - 1.1e-222 715.6 121.0 7.9e-11 42.2 0.3 25.0 24 1 1 25 25 25 25 Sel1 repeat TPR_16 PF13432.1 ESA02069.1 - 5e-07 30.2 1.8 3.8 8.3 0.0 9.3 10 3 3 13 13 13 1 Tetratricopeptide repeat DUF2530 PF10745.4 ESA02069.1 - 0.0017 18.2 0.0 1.3e+02 2.6 0.0 6.6 9 0 0 9 9 9 0 Protein of unknown function (DUF2530) TPR_6 PF13174.1 ESA02069.1 - 0.031 14.7 9.2 26 5.5 0.1 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat Dabb PF07876.7 ESA02069.1 - 0.1 13.0 6.8 1.2e+02 3.1 0.0 6.6 7 1 0 8 8 8 0 Stress responsive A/B Barrel Domain Ytp1 PF10355.4 ESA02072.1 - 8.8e-35 120.2 4.0 8.8e-35 120.2 2.8 2.2 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 ESA02072.1 - 2.3e-21 75.3 7.2 2.3e-21 75.3 5.0 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.11 ESA02072.1 - 2.9e-05 23.9 3.1 2.9e-05 23.9 2.1 3.0 3 1 1 4 4 4 1 Eukaryotic cytochrome b561 Tetraspannin PF00335.15 ESA02072.1 - 0.0018 17.6 4.1 0.0018 17.6 2.8 3.1 3 0 0 3 3 3 1 Tetraspanin family DUF3902 PF13042.1 ESA02072.1 - 0.0093 15.2 10.4 0.0093 15.2 7.2 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3902) DUF4131 PF13567.1 ESA02072.1 - 0.095 12.1 3.7 0.31 10.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Bap31 PF05529.7 ESA02072.1 - 2.1 7.7 6.6 14 5.1 0.0 2.7 3 0 0 3 3 3 0 B-cell receptor-associated protein 31-like Epiglycanin_TR PF05647.6 ESA02073.1 - 0.71 9.7 12.1 2.5 7.9 8.4 1.8 1 1 0 1 1 1 0 Tandem-repeating region of mucin, epiglycanin-like HTH_45 PF14947.1 ESA02076.1 - 0.00073 19.2 0.1 0.001 18.8 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1870 PF08965.5 ESA02078.1 - 0.086 12.5 0.2 0.097 12.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) ubiquitin PF00240.18 ESA02086.1 - 9.1e-07 28.1 0.1 1.3e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family ubiquitin PF00240.18 ESA02087.1 - 2.4e-16 58.8 0.1 4.9e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA02087.1 - 3e-06 26.8 0.1 4.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA02087.1 - 0.0052 16.9 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 ESA02088.1 - 2.4e-25 87.7 0.4 4.3e-25 86.9 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA02088.1 - 2e-09 37.0 0.3 3.7e-09 36.1 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA02088.1 - 0.0042 17.3 0.2 0.012 15.8 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain DUF3990 PF13151.1 ESA02088.1 - 0.061 12.7 0.0 0.21 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3990) Telomere_Sde2 PF13019.1 ESA02088.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Telomere stability and silencing CMV_1a PF12467.3 ESA02089.1 - 0.0036 17.7 6.0 0.0036 17.7 4.2 2.4 2 0 0 2 2 2 1 Cucumber mosaic virus 1a protein family DUF1861 PF08950.5 ESA02094.1 - 0.0037 16.1 0.0 0.0068 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) DUF3684 PF12449.3 ESA02095.1 - 8.6e-23 79.9 0.1 1.4e-20 72.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3684) zf-rbx1 PF12678.2 ESA02095.1 - 0.06 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger ABC2_membrane_3 PF12698.2 ESA02095.1 - 0.32 9.9 2.0 0.52 9.2 1.3 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein p450 PF00067.17 ESA02096.1 - 6.1e-56 189.8 0.6 8.2e-56 189.4 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 NIF PF03031.13 ESA02097.1 - 1.5e-22 79.9 3.7 2.8e-22 79.0 2.5 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Dimer_Tnp_hAT PF05699.9 ESA02100.1 - 3.2e-19 68.3 0.7 3.4e-19 68.2 0.5 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2670 PF10875.3 ESA02101.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) FAR1 PF03101.10 ESA02103.1 - 0.00014 22.3 3.4 0.00028 21.3 2.4 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain CMS1 PF14617.1 ESA02103.1 - 0.044 12.8 0.1 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit OGG_N PF07934.7 ESA02104.1 - 7.8e-35 119.3 0.7 1.5e-34 118.4 0.5 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 ESA02104.1 - 4.1e-18 65.6 0.0 1.1e-17 64.2 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESA02104.1 - 0.0063 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif 7kD_DNA_binding PF02294.13 ESA02105.1 - 0.037 13.7 0.3 0.059 13.0 0.2 1.3 1 0 0 1 1 1 0 7kD DNA-binding domain BTB PF00651.26 ESA02107.1 - 8.2e-18 64.4 0.2 8.2e-18 64.4 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA02107.1 - 2.5e-16 59.9 3.6 4.1e-16 59.2 2.1 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02107.1 - 1.5e-06 27.9 0.4 5.9e-06 26.0 0.1 2.2 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA02107.1 - 0.0022 17.2 0.5 0.0038 16.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.26 ESA02108.1 - 1.8e-17 63.2 0.9 2.6e-17 62.7 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA02108.1 - 3.8e-16 59.3 4.2 3.8e-16 59.3 2.9 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02108.1 - 0.00018 21.3 0.5 0.0006 19.6 0.1 2.1 1 1 0 1 1 1 1 BTB And C-terminal Kelch FYRC PF05965.9 ESA02110.1 - 0.0026 17.5 0.1 0.062 13.1 0.0 2.4 2 0 0 2 2 2 1 F/Y rich C-terminus RRM_1 PF00076.17 ESA02111.1 - 0.0032 17.0 0.0 0.0055 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3521 PF12035.3 ESA02111.1 - 0.084 12.7 0.2 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3521) SAM_2 PF07647.12 ESA02112.1 - 0.0016 18.2 0.1 0.0026 17.5 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA02112.1 - 0.004 17.2 0.0 0.0054 16.8 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DDE_3 PF13358.1 ESA02113.1 - 1.4e-09 37.8 0.0 1.7e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 ESA02113.1 - 0.0088 14.8 0.0 0.009 14.7 0.0 1.1 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain DUF4248 PF14053.1 ESA02113.1 - 0.012 15.1 0.0 0.018 14.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4248) Cu-oxidase_3 PF07732.10 ESA02114.1 - 1.4e-42 144.1 10.6 6.7e-42 141.9 0.5 4.6 4 1 1 5 5 5 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA02114.1 - 3.7e-37 126.9 6.2 1.2e-33 115.4 0.5 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 ESA02114.1 - 9.9e-37 126.2 0.2 2.5e-36 124.9 0.0 1.9 2 0 0 2 2 2 1 Multicopper oxidase DUF1722 PF08349.6 ESA02115.1 - 1.9e-05 24.5 0.5 4.8e-05 23.2 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1722) PRANC PF09372.5 ESA02115.1 - 0.01 15.7 2.4 0.01 15.7 1.6 2.3 2 1 0 2 2 2 0 PRANC domain RelB_N PF12910.2 ESA02115.1 - 0.015 14.6 0.0 0.07 12.4 0.0 2.1 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin stability system N-terminal HTH_29 PF13551.1 ESA02117.1 - 5.3e-08 32.9 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.1 ESA02117.1 - 5.1e-05 22.7 0.0 0.00011 21.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.1 ESA02117.1 - 0.00011 22.1 0.0 0.00022 21.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA02117.1 - 0.00025 20.5 0.0 0.00038 20.0 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.7 ESA02117.1 - 0.0055 16.2 0.0 0.0078 15.7 0.0 1.2 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) KorB PF08535.5 ESA02117.1 - 0.013 15.6 0.0 0.032 14.3 0.0 1.6 1 1 1 2 2 2 0 KorB domain HTH_40 PF14493.1 ESA02117.1 - 0.019 15.1 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_32 PF13565.1 ESA02117.1 - 0.024 15.4 0.0 0.047 14.5 0.0 1.5 2 0 0 2 2 2 0 Homeodomain-like domain MarR PF01047.17 ESA02117.1 - 0.079 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 MarR family Wbp11 PF09429.5 ESA02117.1 - 0.33 10.9 1.9 22 5.1 1.5 2.6 1 1 0 1 1 1 0 WW domain binding protein 11 Rhodanese PF00581.15 ESA02120.1 - 2.5e-11 43.9 0.0 3e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain LMWPc PF01451.16 ESA02120.1 - 0.013 15.8 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase DUF1542 PF07564.6 ESA02121.1 - 0.054 13.5 1.9 0.054 13.5 1.3 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA02121.1 - 0.067 12.9 0.2 0.086 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 Scaffolding_pro PF11418.3 ESA02121.1 - 0.094 13.0 0.3 0.27 11.5 0.2 1.7 1 1 1 2 2 2 0 Phi29 scaffolding protein Methyltransf_11 PF08241.7 ESA02122.1 - 1.8e-05 25.1 0.0 3.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA02122.1 - 3.7e-05 23.3 0.1 4.8e-05 22.9 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA02122.1 - 0.00051 19.7 0.0 0.00072 19.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA02122.1 - 0.0011 18.1 0.0 0.0022 17.1 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.10 ESA02122.1 - 0.0016 18.0 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_25 PF13649.1 ESA02122.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain M20_dimer PF07687.9 ESA02124.1 - 6.3e-08 32.3 0.0 1.4e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESA02124.1 - 2.4e-07 30.4 0.0 3.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 HSP70 PF00012.15 ESA02126.1 - 4.7e-261 866.9 15.3 5.3e-261 866.7 10.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA02126.1 - 1.8e-11 43.2 8.2 3.1e-11 42.4 1.4 2.7 3 0 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.11 ESA02126.1 - 0.012 15.2 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 ESA02126.1 - 0.096 12.5 13.7 1 9.1 0.0 4.7 4 1 0 4 4 4 0 Cell division protein FtsA MscL PF01741.13 ESA02127.1 - 0.059 13.5 0.8 0.067 13.3 0.6 1.2 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL PHD PF00628.24 ESA02128.1 - 6.4e-08 32.1 12.0 1.6e-07 30.8 8.3 1.7 1 0 0 1 1 1 1 PHD-finger SET PF00856.23 ESA02128.1 - 4.3e-06 27.1 0.0 4.3e-06 27.1 0.0 3.9 3 2 0 3 3 3 1 SET domain zf-CW PF07496.10 ESA02128.1 - 0.065 12.9 4.0 0.16 11.6 2.8 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger PHD_2 PF13831.1 ESA02128.1 - 2.6 7.4 8.8 2.1 7.7 4.5 2.0 2 0 0 2 2 2 0 PHD-finger Prefoldin_2 PF01920.15 ESA02130.1 - 0.002 17.8 0.9 0.002 17.8 0.6 1.4 2 0 0 2 2 2 1 Prefoldin subunit DUF2046 PF09755.4 ESA02130.1 - 0.0028 16.5 1.0 0.0034 16.3 0.7 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) NTR2 PF15458.1 ESA02130.1 - 0.01 15.0 1.1 0.011 14.9 0.8 1.1 1 0 0 1 1 1 0 Nineteen complex-related protein 2 DUF1202 PF06717.6 ESA02130.1 - 0.013 14.8 0.4 0.014 14.7 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) DUF972 PF06156.8 ESA02130.1 - 0.021 15.1 1.5 0.027 14.7 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CASP_C PF08172.7 ESA02130.1 - 0.024 13.6 3.0 0.034 13.1 2.0 1.3 1 1 0 1 1 1 0 CASP C terminal Cortex-I_coil PF09304.5 ESA02130.1 - 0.028 14.4 1.8 0.035 14.1 1.2 1.1 1 0 0 1 1 1 0 Cortexillin I, coiled coil DMPK_coil PF08826.5 ESA02130.1 - 0.038 13.8 2.9 0.057 13.3 1.9 1.5 1 1 0 1 1 1 0 DMPK coiled coil domain like UPF0020 PF01170.13 ESA02130.1 - 0.04 13.5 0.0 0.042 13.4 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DivIC PF04977.10 ESA02130.1 - 0.16 11.4 1.4 0.25 10.8 0.8 1.5 1 1 0 1 1 1 0 Septum formation initiator Uma2 PF05685.7 ESA02131.1 - 1.8e-13 50.1 0.0 2.1e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 Putative restriction endonuclease HTH_17 PF12728.2 ESA02134.1 - 0.029 14.6 0.8 0.071 13.3 0.6 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain YopE_N PF09020.5 ESA02135.1 - 0.068 13.2 0.3 0.4 10.7 0.0 2.3 2 0 0 2 2 2 0 YopE, N terminal Secretin_N_2 PF07655.8 ESA02137.1 - 1.6 9.1 11.7 0.11 12.9 4.7 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain zf-RING_2 PF13639.1 ESA02139.1 - 4.7e-08 32.7 4.6 8.1e-08 31.9 3.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA02139.1 - 3.9e-05 23.2 2.1 6.7e-05 22.4 1.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA02139.1 - 4.5e-05 23.3 4.6 4.5e-05 23.3 3.2 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA02139.1 - 0.00024 21.1 1.1 0.00054 20.0 0.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA02139.1 - 0.00055 19.5 3.9 0.0011 18.5 2.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA02139.1 - 0.0033 17.1 2.1 0.02 14.5 0.3 3.0 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA02139.1 - 0.0046 16.6 4.0 0.0092 15.6 2.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING-like PF08746.6 ESA02139.1 - 0.023 14.6 1.5 0.057 13.4 1.0 1.7 1 1 0 1 1 1 0 RING-like domain PHD PF00628.24 ESA02139.1 - 0.039 13.6 1.5 0.076 12.7 1.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_6 PF14835.1 ESA02139.1 - 0.041 13.6 1.4 0.087 12.6 1.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 ESA02139.1 - 0.055 13.2 1.1 0.12 12.1 0.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger NOA36 PF06524.7 ESA02139.1 - 0.075 12.2 9.5 0.079 12.2 5.5 1.9 1 1 0 1 1 1 0 NOA36 protein Baculo_RING PF05883.6 ESA02139.1 - 0.076 12.8 0.3 0.19 11.5 0.2 1.6 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-C3HC4_4 PF15227.1 ESA02139.1 - 0.11 12.3 2.9 0.26 11.1 2.0 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING DAP3 PF10236.4 ESA02140.1 - 0.04 12.8 0.0 0.067 12.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Corona_nucleoca PF00937.13 ESA02141.1 - 0.019 13.9 4.3 0.021 13.7 3.0 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein VirionAssem_T7 PF11653.3 ESA02141.1 - 0.3 11.8 1.4 0.85 10.4 0.1 1.9 1 1 1 2 2 2 0 Bacteriophage T7 virion assembly protein CTNNB1_binding PF08347.6 ESA02141.1 - 0.32 11.2 2.7 0.37 11.0 1.9 1.1 1 0 0 1 1 1 0 N-terminal CTNNB1 binding CDC45 PF02724.9 ESA02141.1 - 1.2 7.1 5.2 1.1 7.1 3.6 1.2 1 0 0 1 1 1 0 CDC45-like protein AIG1 PF04548.11 ESA02142.1 - 1.6e-11 43.6 4.9 1.6e-11 43.6 3.4 3.0 3 1 1 4 4 4 1 AIG1 family MMR_HSR1 PF01926.18 ESA02142.1 - 1.1e-06 28.6 2.0 4.5e-06 26.5 0.1 2.7 2 1 0 3 3 3 1 50S ribosome-binding GTPase Septin PF00735.13 ESA02142.1 - 0.00025 20.1 0.4 0.00025 20.1 0.3 2.8 3 1 0 3 3 3 1 Septin Enterotoxin_b PF01376.13 ESA02142.1 - 0.022 14.6 4.8 0.03 14.1 0.3 2.9 2 1 1 3 3 3 0 Heat-labile enterotoxin beta chain DUF258 PF03193.11 ESA02142.1 - 0.11 11.6 0.1 0.11 11.6 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function, DUF258 DUF1515 PF07439.6 ESA02142.1 - 0.46 10.3 2.5 5.3 6.8 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF1664 PF07889.7 ESA02142.1 - 3.3 7.5 12.8 0.053 13.3 1.7 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Peptidase_S46 PF10459.4 ESA02143.1 - 0.079 11.3 2.9 0.088 11.2 2.0 1.0 1 0 0 1 1 1 0 Peptidase S46 PSCyt3 PF07627.6 ESA02143.1 - 0.34 10.7 2.2 0.49 10.2 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) Cytochrom_c3_2 PF14537.1 ESA02143.1 - 7.2 7.0 8.7 8.4 6.8 3.6 2.3 2 1 0 2 2 2 0 Cytochrome c3 DNA_pol_lambd_f PF10391.4 ESA02144.1 - 0.088 12.3 0.0 2.9 7.5 0.0 2.7 1 1 1 2 2 2 0 Fingers domain of DNA polymerase lambda Pkinase PF00069.20 ESA02145.1 - 3.8e-40 137.6 0.0 6.1e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02145.1 - 6.7e-40 136.7 0.0 8.3e-40 136.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ICE2 PF08426.5 ESA02146.1 - 0.068 11.7 0.0 0.096 11.2 0.0 1.1 1 0 0 1 1 1 0 ICE2 BTB PF00651.26 ESA02153.1 - 2.3e-16 59.7 0.0 4.6e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02153.1 - 5.5e-12 45.8 1.1 1.4e-11 44.5 0.1 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02153.1 - 0.0012 18.6 2.9 0.039 13.8 0.2 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch FANCI_S2 PF14676.1 ESA02153.1 - 0.097 12.5 1.4 0.17 11.7 1.0 1.4 1 0 0 1 1 1 0 FANCI solenoid 2 p450 PF00067.17 ESA02156.1 - 1.9e-49 168.4 0.1 2.5e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SPRY PF00622.23 ESA02159.1 - 5.8e-22 78.0 0.2 6.5e-22 77.9 0.2 1.0 1 0 0 1 1 1 1 SPRY domain Kelch_3 PF13415.1 ESA02161.1 - 2.1e-13 49.9 2.2 0.00026 21.0 0.1 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA02161.1 - 3.1e-12 46.0 1.3 7.6e-07 28.8 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA02161.1 - 5.8e-12 45.2 0.0 5.5e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA02161.1 - 0.00061 19.4 0.2 0.076 12.8 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.1 ESA02161.1 - 0.00081 19.4 2.5 0.14 12.4 0.0 3.3 2 1 1 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESA02161.1 - 0.00083 18.8 4.3 0.9 9.1 0.0 3.3 3 0 0 3 3 3 2 Kelch motif LVIVD PF08309.6 ESA02161.1 - 0.18 10.8 0.9 14 4.7 0.0 2.7 3 0 0 3 3 3 0 LVIVD repeat zf-C2H2 PF00096.21 ESA02162.1 - 9.6e-05 22.5 0.8 0.00025 21.2 0.5 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA02162.1 - 0.0081 16.4 0.2 0.019 15.2 0.2 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger DUF4659 PF15558.1 ESA02162.1 - 0.082 11.5 18.9 0.088 11.4 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4659) Nucleo_P87 PF07267.6 ESA02162.1 - 0.35 9.5 10.9 0.4 9.3 7.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Med5 PF08689.5 ESA02162.1 - 0.53 7.8 8.8 0.54 7.8 6.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit Med5 MIP-T3 PF10243.4 ESA02162.1 - 1.9 6.8 22.7 2 6.7 15.7 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Lin-8 PF03353.10 ESA02162.1 - 2.1 7.5 15.1 2.4 7.3 10.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4175 PF13779.1 ESA02162.1 - 4.4 4.8 16.1 4.7 4.7 11.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF2146 PF10220.4 ESA02162.1 - 6 4.7 11.2 6.4 4.6 7.8 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2146) Asp-B-Hydro_N PF05279.6 ESA02162.1 - 8.3 6.1 7.8 10 5.9 5.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RRM_2 PF04059.7 ESA02163.1 - 0.055 13.4 0.1 0.11 12.4 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif 2 zf-H2C2 PF09337.5 ESA02163.1 - 0.071 12.5 0.8 0.071 12.5 0.5 1.8 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger NPV_P10 PF05531.7 ESA02164.1 - 0.00098 19.3 1.1 0.00098 19.3 0.8 2.0 3 0 0 3 3 2 1 Nucleopolyhedrovirus P10 protein Atg14 PF10186.4 ESA02164.1 - 0.0029 16.6 3.8 0.0047 15.9 2.6 1.3 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 RPW8 PF05659.6 ESA02164.1 - 0.0089 15.5 0.7 0.0089 15.5 0.5 2.3 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4404 PF14357.1 ESA02164.1 - 0.058 13.8 1.8 0.21 12.0 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) WEMBL PF05701.6 ESA02164.1 - 0.09 11.2 8.0 0.042 12.3 1.3 2.1 1 1 0 2 2 2 0 Weak chloroplast movement under blue light DUF4094 PF13334.1 ESA02164.1 - 0.16 12.3 1.0 0.5 10.7 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF641 PF04859.7 ESA02164.1 - 0.21 11.3 3.6 0.13 11.9 0.8 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) IncA PF04156.9 ESA02164.1 - 0.43 10.1 4.1 0.27 10.8 1.3 1.6 1 1 0 1 1 1 0 IncA protein DUF3573 PF12097.3 ESA02164.1 - 0.52 8.8 4.8 2.2 6.7 3.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) DUF2408 PF10303.4 ESA02164.1 - 0.71 9.9 9.6 0.27 11.3 4.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Spc24 PF08286.6 ESA02164.1 - 1.3 8.7 12.9 0.57 9.9 5.9 2.6 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 FlxA PF14282.1 ESA02164.1 - 1.5 8.8 8.6 0.17 11.8 2.1 2.2 2 0 0 2 2 2 0 FlxA-like protein Nsp1_C PF05064.8 ESA02164.1 - 1.5 8.4 8.6 0.066 12.8 0.8 2.4 3 0 0 3 3 3 0 Nsp1-like C-terminal region DUF2175 PF09943.4 ESA02164.1 - 3.1 7.9 5.6 4.7 7.3 0.9 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) BLOC1_2 PF10046.4 ESA02164.1 - 4.1 7.6 13.6 0.15 12.2 2.9 3.1 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 ESA02164.1 - 4.1 7.7 12.4 0.059 13.7 2.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Pkinase PF00069.20 ESA02166.1 - 1e-71 241.1 1.6 2e-36 125.4 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02166.1 - 5.6e-69 232.1 0.1 3e-33 115.0 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Kdo PF06293.9 ESA02166.1 - 8.5e-06 24.9 0.1 0.0024 16.9 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA02166.1 - 0.0081 15.9 0.7 0.65 9.6 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA02166.1 - 0.021 14.4 6.3 0.7 9.4 0.6 3.0 2 2 1 3 3 3 0 Choline/ethanolamine kinase RIO1 PF01163.17 ESA02166.1 - 0.12 11.7 0.6 3.7 6.8 0.0 2.5 2 0 0 2 2 2 0 RIO1 family Pkinase_Tyr PF07714.12 ESA02167.1 - 1.2e-80 270.3 0.1 5.1e-50 169.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA02167.1 - 1.3e-75 253.9 3.3 1.4e-44 152.2 0.3 2.2 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.9 ESA02167.1 - 7.9e-07 28.3 0.2 0.022 13.8 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA02167.1 - 0.0013 18.5 0.5 0.72 9.5 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family PolC_DP2 PF03833.8 ESA02167.1 - 0.78 7.3 3.5 0.64 7.6 0.1 2.2 2 1 0 3 3 3 0 DNA polymerase II large subunit DP2 DUF2457 PF10446.4 ESA02168.1 - 0.11 11.1 0.1 0.15 10.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pkinase PF00069.20 ESA02169.1 - 4.6e-43 147.2 0.8 5.6e-43 146.9 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02169.1 - 1.5e-38 132.3 0.1 1.8e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA02169.1 - 1e-06 27.9 0.0 6.2e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA02169.1 - 3.6e-05 23.2 0.9 0.0011 18.3 0.1 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA02169.1 - 0.0019 17.2 0.0 0.0031 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SWIM PF04434.12 ESA02169.1 - 0.0051 16.2 0.7 0.01 15.2 0.5 1.5 1 0 0 1 1 1 1 SWIM zinc finger APH PF01636.18 ESA02169.1 - 0.05 13.3 0.4 0.42 10.2 0.6 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA02170.1 - 2.3e-11 43.2 0.6 8e-11 41.4 0.4 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA02170.1 - 0.00011 21.7 0.2 0.00051 19.6 0.1 2.2 1 0 0 1 1 1 1 F-box domain DUF747 PF05346.6 ESA02171.1 - 1.8e-114 382.2 8.7 2.6e-114 381.7 6.0 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family ATP-synt_E PF05680.7 ESA02171.1 - 0.049 13.5 0.3 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 ATP synthase E chain DUF2951 PF11166.3 ESA02171.1 - 0.92 9.4 0.0 0.92 9.4 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2951) Pex24p PF06398.6 ESA02171.1 - 1.7 7.3 6.5 0.94 8.2 0.0 2.7 2 1 1 3 3 3 0 Integral peroxisomal membrane peroxin BTB PF00651.26 ESA02172.1 - 7.4e-32 109.6 1.2 6.7e-17 61.4 0.0 3.5 3 1 1 4 4 4 2 BTB/POZ domain Ank_2 PF12796.2 ESA02172.1 - 2.9e-09 37.1 0.0 1.6e-08 34.7 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA02172.1 - 2.4e-08 33.4 0.1 8e-06 25.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.25 ESA02172.1 - 5.9e-08 32.1 0.0 1.5e-06 27.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 ESA02172.1 - 5.7e-06 26.7 0.0 3.2e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA02172.1 - 1.2e-05 25.3 0.0 0.00049 20.2 0.0 2.9 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Cache_2 PF08269.6 ESA02172.1 - 0.025 14.5 0.5 0.056 13.4 0.3 1.5 1 0 0 1 1 1 0 Cache domain PCI PF01399.22 ESA02172.1 - 0.099 12.9 2.3 1.3 9.3 0.0 3.4 3 1 1 4 4 4 0 PCI domain Glyco_hydro_20 PF00728.17 ESA02173.1 - 2e-97 326.5 0.3 2.8e-97 326.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 ESA02173.1 - 3.1e-17 63.4 0.1 3.1e-17 63.4 0.1 2.7 3 1 1 4 4 4 1 beta-acetyl hexosaminidase like WD40 PF00400.27 ESA02174.1 - 1.9e-35 119.4 4.2 2.3e-07 30.4 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Prp19 PF08606.6 ESA02174.1 - 2.5e-35 119.9 2.8 4.5e-35 119.1 1.9 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like zf-Nse PF11789.3 ESA02174.1 - 0.036 13.6 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Pkinase PF00069.20 ESA02175.1 - 1.1e-49 168.9 2.5 1.6e-49 168.3 1.7 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02175.1 - 2e-28 99.1 0.1 2.8e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA02175.1 - 6.6e-05 22.7 0.0 8.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA02175.1 - 0.00036 19.6 0.2 0.00054 19.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA02175.1 - 0.00049 19.1 0.0 0.00088 18.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA02175.1 - 0.0012 18.1 0.4 0.0035 16.6 0.0 1.9 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL FHA PF00498.21 ESA02175.1 - 0.0033 17.4 0.1 0.012 15.7 0.0 2.0 2 0 0 2 2 2 1 FHA domain UNC-93 PF05978.11 ESA02176.1 - 7e-15 54.8 3.9 7e-15 54.8 2.7 2.4 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.11 ESA02176.1 - 8.7e-15 54.2 27.3 1.4e-14 53.6 18.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Pox_D5 PF03288.11 ESA02177.1 - 0.0042 17.3 0.1 0.032 14.5 0.0 2.6 2 0 0 2 2 2 1 Poxvirus D5 protein-like AAA_14 PF13173.1 ESA02181.1 - 0.13 12.1 0.1 0.73 9.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain F-box-like_2 PF13013.1 ESA02183.1 - 0.0097 15.6 1.1 0.29 10.8 0.0 2.1 1 1 1 2 2 2 2 F-box-like domain RTP801_C PF07809.6 ESA02183.1 - 0.087 12.4 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 RTP801 C-terminal region Folate_carrier PF01770.13 ESA02187.1 - 0.0084 14.6 0.8 0.0094 14.5 0.6 1.1 1 0 0 1 1 1 1 Reduced folate carrier AAA_15 PF13175.1 ESA02187.1 - 0.024 13.7 2.0 0.027 13.5 1.4 1.0 1 0 0 1 1 1 0 AAA ATPase domain NUDIX PF00293.23 ESA02189.1 - 1.2e-26 93.0 0.0 1.5e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain GLE1 PF07817.8 ESA02190.1 - 3.4e-46 157.2 1.4 4e-46 157.0 0.9 1.1 1 0 0 1 1 1 1 GLE1-like protein Pox_A3L PF05288.6 ESA02190.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A3L Protein ABC_tran PF00005.22 ESA02191.1 - 4.5e-36 124.1 0.0 7.7e-36 123.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 ESA02191.1 - 8.1e-23 81.2 13.8 1.2e-22 80.6 9.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 ESA02191.1 - 7.9e-07 28.5 0.6 5.1e-05 22.6 0.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA02191.1 - 2.9e-06 27.4 0.0 0.0011 18.9 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA02191.1 - 0.0015 18.5 0.0 0.021 14.8 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 ESA02191.1 - 0.0063 16.0 0.4 0.017 14.6 0.3 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESA02191.1 - 0.0069 15.5 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SbcCD_C PF13558.1 ESA02191.1 - 0.012 15.4 0.1 0.12 12.3 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.15 ESA02191.1 - 0.039 13.6 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_22 PF13401.1 ESA02191.1 - 0.044 13.9 0.2 0.29 11.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain NAPRTase PF04095.11 ESA02191.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family AAA_17 PF13207.1 ESA02191.1 - 0.073 13.8 0.0 0.18 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESA02191.1 - 0.082 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA PF00004.24 ESA02191.1 - 0.085 13.0 0.0 1.8 8.7 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-CSL PF05207.8 ESA02192.1 - 1.8e-26 91.3 1.7 2.6e-26 90.8 1.2 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.5 ESA02192.1 - 0.0089 15.9 0.6 0.017 15.0 0.4 1.5 1 0 0 1 1 1 1 Zinc ribbon domain zf-RING_4 PF14570.1 ESA02192.1 - 0.29 10.7 3.0 0.69 9.5 2.1 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain MbeD_MobD PF04899.7 ESA02193.1 - 0.092 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 MbeD/MobD like FAD_binding_1 PF00667.15 ESA02196.1 - 2.9e-59 200.1 0.0 4.2e-59 199.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 ESA02196.1 - 7.4e-33 113.5 0.3 1.7e-32 112.4 0.1 1.7 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.16 ESA02196.1 - 3.8e-18 66.0 0.1 1.3e-16 61.1 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAGLU PF05089.7 ESA02196.1 - 0.0092 14.7 0.1 0.016 13.9 0.0 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain APS_kinase PF01583.15 ESA02197.1 - 7.3e-72 240.1 0.0 8.8e-72 239.8 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 ESA02197.1 - 9.2e-10 38.5 0.0 1.3e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA02197.1 - 1e-05 26.2 0.0 1.5e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA02197.1 - 2.8e-05 24.4 0.1 7.8e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESA02197.1 - 0.0074 15.5 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.1 ESA02197.1 - 0.044 13.3 0.1 0.079 12.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Torsin PF06309.6 ESA02197.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Torsin Lipase_GDSL_2 PF13472.1 ESA02198.1 - 0.00047 20.3 0.0 0.00055 20.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESA02198.1 - 0.095 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Vps51 PF08700.6 ESA02200.1 - 0.052 13.3 0.7 0.083 12.7 0.2 1.5 1 1 1 2 2 2 0 Vps51/Vps67 M_domain PF12938.2 ESA02200.1 - 0.063 13.0 0.3 0.063 13.0 0.2 1.0 1 0 0 1 1 1 0 M domain of GW182 Ded_cyto PF06920.8 ESA02200.1 - 0.063 12.5 1.0 0.08 12.2 0.6 1.3 1 1 0 1 1 1 0 Dedicator of cytokinesis YgaB PF14182.1 ESA02200.1 - 0.074 13.3 1.8 0.082 13.1 1.2 1.2 1 0 0 1 1 1 0 YgaB-like protein Gon7 PF08738.5 ESA02200.1 - 0.087 12.8 0.5 0.1 12.6 0.4 1.1 1 0 0 1 1 1 0 Gon7 family K-box PF01486.12 ESA02200.1 - 0.15 11.8 4.3 0.16 11.7 3.0 1.0 1 0 0 1 1 1 0 K-box region ALMT PF11744.3 ESA02200.1 - 0.19 10.3 2.2 0.18 10.4 1.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Fib_alpha PF08702.5 ESA02200.1 - 0.28 11.3 2.3 0.29 11.2 1.6 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1049 PF06305.6 ESA02200.1 - 0.33 10.4 1.4 0.4 10.1 1.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1049) ACCA PF03255.9 ESA02200.1 - 0.36 10.3 2.1 0.34 10.4 1.4 1.0 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TMF_DNA_bd PF12329.3 ESA02200.1 - 0.44 10.3 6.6 0.99 9.2 4.6 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Filament PF00038.16 ESA02201.1 - 7.2e-05 22.4 14.7 0.0001 21.9 10.2 1.2 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.6 ESA02201.1 - 0.00034 20.4 7.3 0.00034 20.4 5.1 2.0 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) EzrA PF06160.7 ESA02201.1 - 0.00035 18.9 15.3 0.00095 17.4 10.6 1.6 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4164 PF13747.1 ESA02201.1 - 0.00076 19.5 7.2 0.0012 18.9 0.9 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4164) Reo_sigmaC PF04582.7 ESA02201.1 - 0.0011 18.2 0.3 0.0012 18.0 0.2 1.0 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF3584 PF12128.3 ESA02201.1 - 0.0028 15.0 12.7 0.0031 14.9 8.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Syntaxin PF00804.20 ESA02201.1 - 0.0053 16.9 8.0 0.0053 16.9 5.5 2.0 1 1 1 2 2 2 1 Syntaxin Phage_GP20 PF06810.6 ESA02201.1 - 0.0061 16.0 17.0 0.016 14.6 11.8 1.7 1 1 0 1 1 1 1 Phage minor structural protein GP20 Myosin_tail_1 PF01576.14 ESA02201.1 - 0.008 13.9 14.3 0.0092 13.7 9.9 1.0 1 0 0 1 1 1 1 Myosin tail Laminin_II PF06009.7 ESA02201.1 - 0.01 15.6 11.8 0.02 14.6 3.2 2.0 1 1 1 2 2 2 1 Laminin Domain II DUF869 PF05911.6 ESA02201.1 - 0.01 14.1 11.7 0.011 13.9 8.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) CENP-F_leu_zip PF10473.4 ESA02201.1 - 0.012 15.5 13.4 0.026 14.4 5.9 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CCDC155 PF14662.1 ESA02201.1 - 0.012 15.2 10.9 0.017 14.7 7.6 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Baculo_PEP_C PF04513.7 ESA02201.1 - 0.017 14.9 4.5 0.028 14.2 3.1 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.8 ESA02201.1 - 0.019 14.0 12.9 0.022 13.8 8.9 1.0 1 0 0 1 1 1 0 TMPIT-like protein PilJ PF13675.1 ESA02201.1 - 0.02 15.1 2.6 0.026 14.8 1.8 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF848 PF05852.6 ESA02201.1 - 0.022 14.5 8.7 0.029 14.2 6.0 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Spc7 PF08317.6 ESA02201.1 - 0.028 13.0 15.6 0.032 12.9 10.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein RHSP PF07999.6 ESA02201.1 - 0.031 12.8 7.0 0.037 12.6 4.8 1.0 1 0 0 1 1 1 0 Retrotransposon hot spot protein DUF885 PF05960.6 ESA02201.1 - 0.033 13.3 6.6 0.034 13.3 4.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) RrnaAD PF00398.15 ESA02201.1 - 0.042 12.8 0.7 0.055 12.5 0.4 1.2 1 1 0 1 1 1 0 Ribosomal RNA adenine dimethylase Laminin_I PF06008.9 ESA02201.1 - 0.045 13.0 11.3 0.059 12.6 7.8 1.1 1 0 0 1 1 1 0 Laminin Domain I PhaP_Bmeg PF09602.5 ESA02201.1 - 0.051 13.3 8.3 0.067 13.0 5.7 1.2 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF2408 PF10303.4 ESA02201.1 - 0.056 13.5 10.1 0.082 13.0 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Tropomyosin_1 PF12718.2 ESA02201.1 - 0.058 13.2 15.4 0.1 12.4 10.7 1.3 1 1 0 1 1 1 0 Tropomyosin like Phage_Mu_Gam PF07352.7 ESA02201.1 - 0.061 12.8 13.0 0.37 10.3 9.0 1.9 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF3847 PF12958.2 ESA02201.1 - 0.075 12.7 16.3 0.72 9.6 5.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) TBPIP PF07106.8 ESA02201.1 - 0.076 12.5 17.0 0.092 12.2 11.8 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF724 PF05266.9 ESA02201.1 - 0.085 12.4 12.8 0.022 14.4 6.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) LdpA_C PF12617.3 ESA02201.1 - 0.094 11.9 1.1 0.13 11.5 0.3 1.4 1 1 0 1 1 1 0 Iron-Sulfur binding protein C terminal Tropomyosin PF00261.15 ESA02201.1 - 0.096 11.7 11.5 0.15 11.1 8.0 1.3 1 0 0 1 1 1 0 Tropomyosin RPW8 PF05659.6 ESA02201.1 - 0.1 12.1 3.5 0.13 11.8 2.4 1.2 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 HCR PF07111.7 ESA02201.1 - 0.11 10.5 5.7 0.13 10.2 3.9 1.0 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) Gp58 PF07902.6 ESA02201.1 - 0.11 10.6 6.3 0.12 10.6 4.3 1.0 1 0 0 1 1 1 0 gp58-like protein ISG65-75 PF11727.3 ESA02201.1 - 0.11 11.4 10.4 0.17 10.9 7.2 1.3 1 1 0 1 1 1 0 Invariant surface glycoprotein DUF4200 PF13863.1 ESA02201.1 - 0.12 12.3 20.3 0.028 14.3 6.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.7 ESA02201.1 - 0.12 12.1 9.4 0.052 13.3 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DASH_Spc34 PF08657.5 ESA02201.1 - 0.13 11.9 18.1 0.2 11.3 10.8 1.8 1 1 1 2 2 2 0 DASH complex subunit Spc34 Apolipoprotein PF01442.13 ESA02201.1 - 0.14 11.6 8.5 0.31 10.5 5.9 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain WEMBL PF05701.6 ESA02201.1 - 0.15 10.4 8.4 0.17 10.3 5.8 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Tet_JBP PF12851.2 ESA02201.1 - 0.15 11.3 2.4 0.18 11.0 1.4 1.3 1 1 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily YlqD PF11068.3 ESA02201.1 - 0.15 12.0 16.8 1 9.3 6.0 2.1 1 1 1 2 2 2 0 YlqD protein Prominin PF05478.6 ESA02201.1 - 0.18 9.3 6.2 0.24 8.9 4.3 1.2 1 0 0 1 1 1 0 Prominin HSCB_C PF07743.8 ESA02201.1 - 0.18 12.2 8.5 0.2 12.1 4.0 2.1 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain LUC7 PF03194.10 ESA02201.1 - 0.21 11.0 9.5 0.24 10.9 6.6 1.0 1 0 0 1 1 1 0 LUC7 N_terminus Prefoldin_2 PF01920.15 ESA02201.1 - 0.22 11.3 20.4 0.49 10.1 2.4 3.0 1 1 2 3 3 3 0 Prefoldin subunit DUF1823 PF08853.6 ESA02201.1 - 0.23 11.1 2.2 0.27 10.9 1.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1823) CHASE3 PF05227.8 ESA02201.1 - 0.23 11.1 5.4 0.33 10.6 3.6 1.3 1 1 0 1 1 1 0 CHASE3 domain Ax_dynein_light PF10211.4 ESA02201.1 - 0.24 11.2 16.0 0.34 10.7 11.1 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain DUF972 PF06156.8 ESA02201.1 - 0.24 11.7 13.7 2.2 8.6 9.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 ESA02201.1 - 0.24 11.2 16.7 0.37 10.6 5.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding V-SNARE PF05008.10 ESA02201.1 - 0.25 11.5 16.1 0.67 10.1 7.1 2.1 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus APG6 PF04111.7 ESA02201.1 - 0.26 10.3 14.4 0.32 10.0 10.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 MCPsignal PF00015.16 ESA02201.1 - 0.28 10.7 3.8 0.67 9.4 2.6 1.6 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlgN PF05130.7 ESA02201.1 - 0.28 11.4 8.2 0.13 12.5 3.2 1.8 1 1 1 2 2 2 0 FlgN protein DUF4527 PF15030.1 ESA02201.1 - 0.32 10.2 3.9 0.38 10.0 2.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4527) Atg14 PF10186.4 ESA02201.1 - 0.36 9.7 18.3 0.63 8.9 10.7 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_13 PF13166.1 ESA02201.1 - 0.41 9.0 16.9 0.55 8.6 11.7 1.2 1 0 0 1 1 1 0 AAA domain PspA_IM30 PF04012.7 ESA02201.1 - 0.41 9.9 9.7 1.7 7.9 5.4 2.1 1 1 1 2 2 2 0 PspA/IM30 family TMF_TATA_bd PF12325.3 ESA02201.1 - 0.42 10.3 12.6 2.1 8.1 8.8 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HOOK PF05622.7 ESA02201.1 - 0.42 8.3 14.3 0.47 8.2 9.9 1.0 1 0 0 1 1 1 0 HOOK protein DUF3552 PF12072.3 ESA02201.1 - 0.44 9.7 17.9 0.34 10.1 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF4201 PF13870.1 ESA02201.1 - 0.45 9.9 16.4 0.15 11.5 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) IncA PF04156.9 ESA02201.1 - 0.46 10.0 14.2 0.79 9.2 9.9 1.4 1 1 0 1 1 1 0 IncA protein DUF573 PF04504.9 ESA02201.1 - 0.46 10.7 10.4 2.2 8.5 1.3 2.4 1 1 2 3 3 3 0 Protein of unknown function, DUF573 MbeD_MobD PF04899.7 ESA02201.1 - 0.46 10.4 8.9 6.6 6.7 6.2 2.6 1 1 0 1 1 1 0 MbeD/MobD like ING PF12998.2 ESA02201.1 - 0.47 10.7 16.8 0.055 13.7 6.3 2.0 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding APG17 PF04108.7 ESA02201.1 - 0.48 9.1 12.3 0.71 8.5 3.1 1.9 1 1 1 2 2 2 0 Autophagy protein Apg17 DUF2317 PF10079.4 ESA02201.1 - 0.51 8.8 10.4 0.67 8.4 7.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) Exonuc_VII_L PF02601.10 ESA02201.1 - 0.55 9.3 12.5 0.67 9.0 8.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3276 PF11680.3 ESA02201.1 - 0.56 10.0 9.2 0.73 9.6 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) V_ATPase_I PF01496.14 ESA02201.1 - 0.6 7.9 10.5 0.81 7.4 7.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Orbi_VP5 PF00901.12 ESA02201.1 - 0.61 8.2 12.9 0.7 8.0 8.9 1.0 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Methyltransf_29 PF03141.11 ESA02201.1 - 0.63 8.3 4.8 0.62 8.3 3.3 1.0 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase IFT57 PF10498.4 ESA02201.1 - 0.66 8.6 17.9 1.6 7.3 12.4 1.5 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 DUF2779 PF11074.3 ESA02201.1 - 0.68 9.9 7.6 0.86 9.6 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) FliJ PF02050.11 ESA02201.1 - 0.77 9.8 19.7 4.3 7.4 13.7 1.9 1 1 0 1 1 1 0 Flagellar FliJ protein CCDC-167 PF15188.1 ESA02201.1 - 0.78 9.7 9.1 4.7 7.2 6.2 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF812 PF05667.6 ESA02201.1 - 0.78 8.1 14.8 1.8 6.9 10.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) SlyX PF04102.7 ESA02201.1 - 0.81 10.1 11.7 1.6 9.1 2.9 2.5 1 1 1 2 2 2 0 SlyX PG_binding_4 PF12229.3 ESA02201.1 - 0.81 9.9 8.6 5.4 7.2 5.5 2.0 1 1 1 2 2 2 0 Putative peptidoglycan binding domain Spectrin PF00435.16 ESA02201.1 - 0.82 9.9 11.6 1.9 8.7 5.5 2.2 1 1 1 2 2 2 0 Spectrin repeat COG2 PF06148.6 ESA02201.1 - 0.84 9.5 8.1 0.59 9.9 1.8 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Nsp1_C PF05064.8 ESA02201.1 - 0.84 9.2 13.9 1.1 8.9 9.6 1.2 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF745 PF05335.8 ESA02201.1 - 0.85 9.1 7.0 1.1 8.8 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF1342 PF07072.6 ESA02201.1 - 0.85 9.2 8.9 2 7.9 6.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1342) NPV_P10 PF05531.7 ESA02201.1 - 0.86 9.8 7.2 15 5.9 5.0 2.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein COG5 PF10392.4 ESA02201.1 - 0.89 9.5 7.3 2.7 7.9 0.4 2.2 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Sipho_Gp157 PF05565.6 ESA02201.1 - 0.91 9.0 13.9 0.63 9.6 1.2 2.1 1 1 1 2 2 2 0 Siphovirus Gp157 TPR_MLP1_2 PF07926.7 ESA02201.1 - 0.92 9.2 19.9 7.4 6.3 13.8 2.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 ESA02201.1 - 0.96 9.0 14.5 2.6 7.6 10.0 1.6 1 1 0 1 1 1 0 Mnd1 family DUF3585 PF12130.3 ESA02201.1 - 0.98 9.2 10.6 0.39 10.5 3.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3585) Cep57_MT_bd PF06657.8 ESA02201.1 - 0.98 9.4 8.2 0.66 9.9 3.5 2.2 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SseC PF04888.7 ESA02201.1 - 0.98 8.6 16.4 0.83 8.9 2.4 2.0 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF3810 PF12725.2 ESA02201.1 - 1 8.1 8.6 1.2 8.0 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Phasin PF05597.6 ESA02201.1 - 1 9.1 6.4 2.2 8.0 1.2 2.6 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FlaC_arch PF05377.6 ESA02201.1 - 1 9.2 12.8 1.1e+02 2.7 0.3 3.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF2852 PF11014.3 ESA02201.1 - 1 9.2 4.1 1.3 8.9 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Fmp27_WPPW PF10359.4 ESA02201.1 - 1.1 7.6 12.7 1.3 7.3 8.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4140 PF13600.1 ESA02201.1 - 1.1 9.7 7.9 3.3 8.2 0.3 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIVA PF05103.8 ESA02201.1 - 1.2 9.2 16.8 2.7 8.0 11.7 1.6 1 1 0 1 1 1 0 DivIVA protein Fib_alpha PF08702.5 ESA02201.1 - 1.2 9.2 16.7 4.8 7.2 11.6 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family ADIP PF11559.3 ESA02201.1 - 1.2 9.0 17.4 0.75 9.6 9.6 1.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ERp29 PF07749.7 ESA02201.1 - 1.4 9.6 6.1 0.46 11.1 1.9 1.8 1 1 1 2 2 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF2130 PF09903.4 ESA02201.1 - 1.4 7.5 15.4 0.22 10.2 5.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF3150 PF11348.3 ESA02201.1 - 1.5 7.8 8.8 2 7.4 5.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3150) LXG PF04740.7 ESA02201.1 - 1.5 8.5 13.7 4.4 7.0 9.3 1.8 1 1 0 1 1 1 0 LXG domain of WXG superfamily Med9 PF07544.8 ESA02201.1 - 1.6 8.5 13.6 83 3.0 9.4 2.8 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Syntaxin-6_N PF09177.6 ESA02201.1 - 1.6 9.1 10.8 2.7 8.4 7.5 1.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF4407 PF14362.1 ESA02201.1 - 1.7 7.5 9.3 15 4.4 2.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Bul1_C PF04426.7 ESA02201.1 - 1.7 7.7 13.2 6.3 5.9 9.3 1.7 1 1 0 1 1 1 0 Bul1 C terminus Mt_ATP-synt_D PF05873.7 ESA02201.1 - 1.7 8.2 9.0 2.6 7.6 6.3 1.3 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) K-box PF01486.12 ESA02201.1 - 1.8 8.4 16.5 10 6.0 4.8 2.8 1 1 2 3 3 3 0 K-box region FadA PF09403.5 ESA02201.1 - 1.8 8.5 13.4 3.4 7.6 2.9 2.2 1 1 1 2 2 2 0 Adhesion protein FadA MbeB_N PF04837.7 ESA02201.1 - 1.8 8.7 7.8 3.9 7.6 0.2 3.0 3 0 0 3 3 2 0 MbeB-like, N-term conserved region ALMT PF11744.3 ESA02201.1 - 1.8 7.1 5.4 2.1 6.8 3.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3508 PF12018.3 ESA02201.1 - 1.9 7.4 11.6 2.2 7.1 8.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) Lipoprotein_6 PF01441.14 ESA02201.1 - 2 8.2 5.9 3 7.6 4.1 1.3 1 0 0 1 1 1 0 Lipoprotein USP8_interact PF08941.5 ESA02201.1 - 2.1 7.6 9.0 5 6.3 6.3 1.7 1 1 0 1 1 1 0 USP8 interacting DUF3450 PF11932.3 ESA02201.1 - 2.2 7.5 16.8 7.6 5.7 11.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) YhdB PF14148.1 ESA02201.1 - 2.3 8.0 7.0 3.1 7.6 2.5 2.6 1 1 1 2 2 2 0 YhdB-like protein PRKCSH-like PF12999.2 ESA02201.1 - 2.4 7.7 8.7 2.6 7.6 4.1 2.1 1 1 1 2 2 2 0 Glucosidase II beta subunit-like ApoO PF09769.4 ESA02201.1 - 2.4 7.8 5.6 6.5 6.4 3.7 1.6 1 1 1 2 2 2 0 Apolipoprotein O IFT46_B_C PF12317.3 ESA02201.1 - 2.5 7.4 9.4 2 7.7 5.0 1.7 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal GrpE PF01025.14 ESA02201.1 - 2.7 7.5 14.7 4.9e+02 0.1 10.2 2.1 1 1 0 1 1 1 0 GrpE THOC7 PF05615.8 ESA02201.1 - 2.7 8.2 18.1 2.3 8.5 4.6 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 Uds1 PF15456.1 ESA02201.1 - 2.7 7.9 9.3 4.5 7.2 6.5 1.4 1 1 0 1 1 1 0 Up-regulated During Septation DivIC PF04977.10 ESA02201.1 - 2.9 7.4 21.3 2 7.9 2.3 3.0 1 1 2 3 3 3 0 Septum formation initiator DUF2203 PF09969.4 ESA02201.1 - 3.1 8.0 9.6 23 5.2 6.7 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) RE_HindIII PF09518.5 ESA02201.1 - 3.1 6.6 15.1 3.5 6.4 10.5 1.0 1 0 0 1 1 1 0 HindIII restriction endonuclease FlxA PF14282.1 ESA02201.1 - 3.3 7.7 21.0 3.9e+02 1.0 14.6 2.7 1 1 0 1 1 1 0 FlxA-like protein DUF948 PF06103.6 ESA02201.1 - 3.3 7.6 6.3 36 4.2 4.3 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) zf-C4H2 PF10146.4 ESA02201.1 - 3.3 7.6 13.5 4.5 7.2 9.3 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein DUF3135 PF11333.3 ESA02201.1 - 3.6 7.8 8.1 1.7 8.8 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) Cluap1 PF10234.4 ESA02201.1 - 3.7 6.6 13.6 5.6 6.0 9.4 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF4250 PF14056.1 ESA02201.1 - 3.7 7.3 7.8 0.68 9.6 1.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4250) DUF4404 PF14357.1 ESA02201.1 - 4.1 7.8 9.9 1.7 9.1 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Med4 PF10018.4 ESA02201.1 - 4.7 6.5 16.3 1.2 8.4 1.8 2.0 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF342 PF03961.8 ESA02201.1 - 4.7 5.5 15.9 7.8 4.7 11.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) BLOC1_2 PF10046.4 ESA02201.1 - 6.1 7.0 16.1 79 3.4 11.2 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_GPO PF05929.6 ESA02201.1 - 6.4 5.9 8.5 20 4.2 5.6 1.7 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF904 PF06005.7 ESA02201.1 - 8.3 6.7 20.1 1.2e+02 3.0 13.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF904) HemX PF04375.9 ESA02201.1 - 8.4 4.8 9.0 10 4.6 6.2 1.2 1 0 0 1 1 1 0 HemX DUF4337 PF14235.1 ESA02201.1 - 8.8 6.1 13.0 7.6 6.3 3.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Spore_III_AF PF09581.5 ESA02201.1 - 9.2 6.0 12.7 1.2e+02 2.3 8.8 2.1 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF4446 PF14584.1 ESA02201.1 - 9.2 6.0 10.2 82 2.9 7.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) YkyA PF10368.4 ESA02201.1 - 9.8 5.4 18.8 0.36 10.1 3.0 2.2 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein Abhydrolase_5 PF12695.2 ESA02202.1 - 1.1e-20 73.8 0.0 1.5e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA02202.1 - 2e-15 57.2 0.0 2.1e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA02202.1 - 1.7e-06 27.7 0.0 1e-05 25.1 0.0 1.7 1 1 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.6 ESA02202.1 - 5.1e-05 23.0 0.0 0.00059 19.5 0.0 2.0 1 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.13 ESA02202.1 - 0.00011 21.5 0.0 0.00055 19.2 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 ESA02202.1 - 0.00014 21.3 0.0 0.00039 19.9 0.0 1.6 1 1 1 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.7 ESA02202.1 - 0.00037 19.0 0.0 0.0072 14.8 0.0 2.1 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.11 ESA02202.1 - 0.00049 19.6 0.0 0.23 10.9 0.0 2.4 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DUF818 PF05677.7 ESA02202.1 - 0.0012 17.6 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) PGAP1 PF07819.8 ESA02202.1 - 0.047 13.2 0.0 1.2 8.6 0.0 2.4 1 1 0 1 1 1 0 PGAP1-like protein Peptidase_S15 PF02129.13 ESA02202.1 - 0.05 13.0 0.0 0.35 10.2 0.0 1.9 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1057 PF06342.7 ESA02202.1 - 0.055 12.2 0.0 0.1 11.4 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.8 ESA02202.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESA02202.1 - 0.13 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Abhydrolase_5 PF12695.2 ESA02203.1 - 4.2e-25 88.1 0.0 6e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA02203.1 - 3e-20 73.1 0.0 5.3e-19 69.0 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA02203.1 - 1.8e-09 37.3 0.1 0.0057 16.1 0.0 3.1 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase AXE1 PF05448.7 ESA02203.1 - 6e-06 24.9 0.0 0.0053 15.2 0.0 2.3 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.15 ESA02203.1 - 3.3e-05 23.5 0.0 0.0005 19.6 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESA02203.1 - 5.3e-05 22.5 0.0 0.00028 20.1 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.6 ESA02203.1 - 0.00018 21.2 0.0 0.009 15.7 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.8 ESA02203.1 - 0.00019 20.9 0.1 0.00044 19.7 0.0 1.6 2 0 0 2 2 2 1 Serine hydrolase (FSH1) DLH PF01738.13 ESA02203.1 - 0.00036 19.8 0.0 0.91 8.7 0.0 2.5 3 0 0 3 3 3 2 Dienelactone hydrolase family Peptidase_S15 PF02129.13 ESA02203.1 - 0.00045 19.7 0.0 0.018 14.4 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PGAP1 PF07819.8 ESA02203.1 - 0.0014 18.3 0.1 0.0041 16.7 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.3 ESA02203.1 - 0.0039 16.9 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase DUF818 PF05677.7 ESA02203.1 - 0.025 13.3 0.0 0.037 12.7 0.0 1.3 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Lipase_3 PF01764.20 ESA02203.1 - 0.094 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.15 ESA02203.1 - 0.13 11.6 0.0 0.34 10.2 0.0 1.8 2 1 0 2 2 2 0 Putative esterase Abhydrolase_5 PF12695.2 ESA02204.1 - 8.8e-19 67.6 0.0 1.2e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA02204.1 - 4.4e-15 56.1 0.0 7.6e-08 32.5 0.0 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA02204.1 - 4.4e-05 23.0 0.0 0.0013 18.1 0.0 2.0 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 ESA02204.1 - 7.7e-05 22.3 0.0 0.0028 17.2 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.13 ESA02204.1 - 0.0033 16.7 0.0 0.042 13.1 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family DUF818 PF05677.7 ESA02204.1 - 0.0043 15.8 0.0 0.0079 14.9 0.0 1.4 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.8 ESA02204.1 - 0.053 12.9 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PMT PF02366.13 ESA02205.1 - 4.7e-81 271.7 24.3 6.1e-81 271.3 16.8 1.1 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 ESA02205.1 - 1.5e-18 66.9 0.7 2.1e-18 66.5 0.5 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.1 ESA02205.1 - 0.00035 20.5 14.4 0.00035 20.5 10.0 1.9 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF1840 PF08895.6 ESA02206.1 - 0.0025 17.7 0.1 0.0038 17.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1840) Pas_Saposin PF09016.5 ESA02206.1 - 0.048 13.6 0.7 0.39 10.7 0.5 2.0 1 1 0 1 1 1 0 Pas factor saposin fold FKBP_N PF01346.13 ESA02206.1 - 0.28 11.2 4.4 0.33 10.9 3.1 1.4 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase OAD_gamma PF04277.8 ESA02207.1 - 1.5 9.2 6.5 3.1 8.2 4.5 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.17 ESA02208.1 - 6.9e-22 76.8 0.1 9.1e-22 76.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02208.1 - 5.2e-15 55.1 0.0 6.7e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02208.1 - 2.5e-10 40.0 0.0 3.3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI3Ka PF00613.15 ESA02209.1 - 8.2e-63 210.9 0.7 8.2e-63 210.9 0.5 1.7 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 ESA02209.1 - 1.4e-47 162.1 0.0 2.1e-46 158.3 0.0 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 ESA02209.1 - 3e-42 143.7 0.0 6e-42 142.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 C2 PF00168.25 ESA02209.1 - 0.00022 20.9 0.6 0.00086 19.1 0.0 2.3 2 0 0 2 2 2 1 C2 domain DUF1433 PF07252.6 ESA02210.1 - 0.18 12.0 0.3 0.18 12.0 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1433) SVA PF05326.6 ESA02212.1 - 0.06 13.1 0.9 0.1 12.3 0.6 1.3 1 0 0 1 1 1 0 Seminal vesicle autoantigen (SVA) ASFV_L11L PF05293.6 ESA02214.1 - 0.02 14.9 0.2 4.1 7.5 0.1 2.4 2 1 0 2 2 2 0 African swine fever virus (ASFV) L11L protein Pox_D5 PF03288.11 ESA02215.1 - 0.061 13.5 0.1 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like LRR_6 PF13516.1 ESA02216.1 - 1.1e-05 25.0 5.4 0.0076 16.2 0.0 3.2 3 1 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.1 ESA02216.1 - 0.00025 20.7 2.5 0.00075 19.2 1.8 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.28 ESA02216.1 - 0.00057 19.5 6.3 0.25 11.5 0.0 3.0 2 1 0 2 2 2 2 Leucine Rich Repeat LRR_4 PF12799.2 ESA02216.1 - 0.0016 17.9 3.5 0.0043 16.6 2.4 1.7 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESA02216.1 - 0.037 14.1 3.2 6.7 7.3 0.0 3.1 2 1 0 2 2 2 0 Leucine rich repeat F-box-like PF12937.2 ESA02219.1 - 6.2e-07 29.0 3.7 6.2e-07 29.0 2.6 2.0 2 0 0 2 2 2 1 F-box-like Herpes_IE68 PF02479.11 ESA02219.1 - 0.042 13.0 0.1 0.49 9.5 0.0 2.0 2 0 0 2 2 2 0 Herpesvirus immediate early protein Pox_A3L PF05288.6 ESA02219.1 - 0.13 12.0 1.2 0.4 10.4 0.1 2.2 2 0 0 2 2 2 0 Poxvirus A3L Protein tRNA-synt_1 PF00133.17 ESA02221.1 - 2.9e-55 187.4 0.0 3.5e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESA02221.1 - 1.3e-17 63.5 0.0 3.2e-17 62.2 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESA02221.1 - 0.0011 18.1 0.3 0.0031 16.6 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Peptidase_C39 PF03412.10 ESA02221.1 - 0.0027 17.5 0.0 0.94 9.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase C39 family tRNA-synt_1 PF00133.17 ESA02222.1 - 1.7e-11 42.8 0.3 2.2e-11 42.4 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1 PF00133.17 ESA02223.1 - 4.9e-09 34.7 0.0 5.1e-09 34.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1 PF00133.17 ESA02224.1 - 1.7e-19 69.2 0.3 6.2e-09 34.4 0.0 3.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) HCV_capsid PF01543.12 ESA02224.1 - 0.011 15.7 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus capsid protein ANT PF03374.9 ESA02224.1 - 0.065 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain DUF751 PF05421.6 ESA02224.1 - 0.14 12.4 1.6 2.6 8.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF751) Pkinase PF00069.20 ESA02226.1 - 7.1e-16 58.1 0.2 8.9e-16 57.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02226.1 - 2.1e-15 56.5 0.0 2.7e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EntA_Immun PF08951.5 ESA02226.1 - 0.0085 16.2 0.5 0.025 14.7 0.1 1.9 2 1 0 2 2 2 1 Enterocin A Immunity APH PF01636.18 ESA02226.1 - 0.018 14.8 0.0 0.022 14.5 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA02226.1 - 0.029 13.7 0.1 0.043 13.1 0.1 1.2 1 0 0 1 1 1 0 RIO1 family YceG PF02618.11 ESA02229.1 - 0.0039 16.2 0.1 0.0057 15.7 0.0 1.2 1 0 0 1 1 1 1 YceG-like family Myosin_tail_1 PF01576.14 ESA02230.1 - 1.1e-05 23.3 3.6 1.4e-05 23.0 2.5 1.0 1 0 0 1 1 1 1 Myosin tail CCDC155 PF14662.1 ESA02230.1 - 2.4e-05 24.0 0.9 2.6e-05 23.9 0.6 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 IncA PF04156.9 ESA02230.1 - 0.00016 21.3 4.6 0.0002 20.9 3.2 1.2 1 0 0 1 1 1 1 IncA protein ADIP PF11559.3 ESA02230.1 - 0.00043 20.2 1.8 0.00058 19.7 1.3 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CENP-Q PF13094.1 ESA02230.1 - 0.00053 20.0 2.7 0.0008 19.4 1.9 1.3 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Laminin_I PF06008.9 ESA02230.1 - 0.00066 19.0 1.9 0.00084 18.7 1.3 1.1 1 0 0 1 1 1 1 Laminin Domain I DASH_Spc34 PF08657.5 ESA02230.1 - 0.00098 18.8 1.0 0.0011 18.7 0.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Spc34 Reo_sigmaC PF04582.7 ESA02230.1 - 0.001 18.3 0.7 0.0011 18.2 0.5 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein EcoR124_C PF12008.3 ESA02230.1 - 0.0011 18.2 0.6 0.0015 17.7 0.4 1.2 1 0 0 1 1 1 1 Type I restriction and modification enzyme - subunit R C terminal AAA_13 PF13166.1 ESA02230.1 - 0.0012 17.3 1.2 0.0014 17.2 0.8 1.0 1 0 0 1 1 1 1 AAA domain DUF4618 PF15397.1 ESA02230.1 - 0.0014 18.0 0.4 0.0018 17.6 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Tropomyosin PF00261.15 ESA02230.1 - 0.0015 17.7 1.3 0.0022 17.1 0.9 1.3 1 0 0 1 1 1 1 Tropomyosin Tropomyosin_1 PF12718.2 ESA02230.1 - 0.0017 18.2 2.8 0.0025 17.6 1.9 1.2 1 0 0 1 1 1 1 Tropomyosin like Spc7 PF08317.6 ESA02230.1 - 0.0018 16.9 2.2 0.0022 16.7 1.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein bZIP_1 PF00170.16 ESA02230.1 - 0.0024 17.7 5.7 0.083 12.8 0.3 2.3 1 1 1 2 2 2 2 bZIP transcription factor Dynamitin PF04912.9 ESA02230.1 - 0.0026 16.6 1.5 0.0051 15.6 0.7 1.5 1 1 0 1 1 1 1 Dynamitin BLOC1_2 PF10046.4 ESA02230.1 - 0.0031 17.6 0.9 0.0044 17.1 0.6 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 HALZ PF02183.13 ESA02230.1 - 0.0032 17.1 7.0 0.26 11.0 1.3 2.4 1 1 1 2 2 2 2 Homeobox associated leucine zipper TBPIP PF07106.8 ESA02230.1 - 0.0036 16.8 1.1 0.0045 16.5 0.8 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Occludin_ELL PF07303.8 ESA02230.1 - 0.0042 17.7 1.2 0.0062 17.2 0.7 1.4 1 1 0 1 1 1 1 Occludin homology domain CENP-F_leu_zip PF10473.4 ESA02230.1 - 0.005 16.7 2.9 0.0081 16.0 2.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.3 ESA02230.1 - 0.0053 16.0 0.5 0.0063 15.8 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) CCDC144C PF14915.1 ESA02230.1 - 0.0055 15.6 0.8 0.0072 15.2 0.6 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region DUF4515 PF14988.1 ESA02230.1 - 0.0058 16.3 2.6 0.0077 15.9 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) DivIC PF04977.10 ESA02230.1 - 0.0061 16.0 4.7 0.027 13.9 0.8 2.2 1 1 1 2 2 2 2 Septum formation initiator Lebercilin PF15619.1 ESA02230.1 - 0.0078 15.6 1.4 0.03 13.7 1.6 1.5 2 0 0 2 2 1 1 Ciliary protein causing Leber congenital amaurosis disease TMF_DNA_bd PF12329.3 ESA02230.1 - 0.0082 15.9 4.2 0.014 15.1 2.9 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding FbpA PF05833.6 ESA02230.1 - 0.0088 14.6 0.6 0.01 14.4 0.4 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Fmp27_WPPW PF10359.4 ESA02230.1 - 0.0094 14.4 0.8 0.0089 14.4 0.5 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DivIVA PF05103.8 ESA02230.1 - 0.0098 15.9 3.1 0.19 11.7 2.1 2.2 1 1 0 1 1 1 1 DivIVA protein ATG16 PF08614.6 ESA02230.1 - 0.0099 15.7 3.3 0.015 15.1 2.3 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) GAS PF13851.1 ESA02230.1 - 0.011 14.9 3.2 0.015 14.4 2.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Prefoldin_2 PF01920.15 ESA02230.1 - 0.012 15.3 3.9 0.047 13.4 2.5 1.8 1 1 1 2 2 2 0 Prefoldin subunit DUF1664 PF07889.7 ESA02230.1 - 0.014 15.2 0.8 0.02 14.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 ESA02230.1 - 0.014 15.8 2.3 0.041 14.2 1.6 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal EzrA PF06160.7 ESA02230.1 - 0.014 13.6 2.1 0.018 13.2 1.5 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA APG6 PF04111.7 ESA02230.1 - 0.015 14.3 2.3 0.018 14.1 1.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 PspA_IM30 PF04012.7 ESA02230.1 - 0.015 14.6 0.8 0.02 14.2 0.5 1.2 1 0 0 1 1 1 0 PspA/IM30 family Toxin_trans PF07952.7 ESA02230.1 - 0.015 14.1 0.3 0.019 13.9 0.2 1.2 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain FliD_C PF07195.7 ESA02230.1 - 0.019 14.2 0.8 0.019 14.2 0.6 1.4 2 0 0 2 2 1 0 Flagellar hook-associated protein 2 C-terminus DUF342 PF03961.8 ESA02230.1 - 0.022 13.1 1.2 0.022 13.1 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF641 PF04859.7 ESA02230.1 - 0.023 14.4 0.9 0.031 14.0 0.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) THOC7 PF05615.8 ESA02230.1 - 0.024 14.8 0.9 0.033 14.4 0.6 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 DASH_Hsk3 PF08227.6 ESA02230.1 - 0.025 14.7 1.4 5.7 7.2 0.0 2.3 1 1 1 2 2 2 0 DASH complex subunit Hsk3 like Med4 PF10018.4 ESA02230.1 - 0.026 13.9 0.4 0.029 13.7 0.2 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Rootletin PF15035.1 ESA02230.1 - 0.027 14.4 1.3 0.036 14.0 0.9 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Tektin PF03148.9 ESA02230.1 - 0.027 13.0 1.4 0.034 12.7 1.0 1.1 1 0 0 1 1 1 0 Tektin family TPR_MLP1_2 PF07926.7 ESA02230.1 - 0.03 14.0 3.1 0.046 13.4 2.2 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.14 ESA02230.1 - 0.03 12.1 0.9 0.027 12.3 0.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Uso1_p115_C PF04871.8 ESA02230.1 - 0.03 14.2 4.0 0.043 13.7 2.8 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.6 ESA02230.1 - 0.031 14.1 3.2 0.096 12.5 0.8 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF3987 PF13148.1 ESA02230.1 - 0.032 12.8 0.2 0.035 12.6 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Vac_Fusion PF02346.11 ESA02230.1 - 0.035 13.5 0.7 0.064 12.6 0.5 1.6 1 0 0 1 1 1 0 Chordopoxvirus fusion protein Rop-like PF05082.8 ESA02230.1 - 0.038 13.4 1.0 0.084 12.3 0.1 1.8 2 0 0 2 2 2 0 Rop-like TTKRSYEDQ PF10212.4 ESA02230.1 - 0.039 12.8 1.9 0.048 12.5 1.3 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Cor1 PF04803.7 ESA02230.1 - 0.041 13.6 0.6 0.055 13.2 0.4 1.2 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region TMPIT PF07851.8 ESA02230.1 - 0.045 12.8 0.7 0.051 12.6 0.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein Mnd1 PF03962.10 ESA02230.1 - 0.048 13.3 0.6 0.075 12.6 0.4 1.3 1 0 0 1 1 1 0 Mnd1 family FemAB PF02388.11 ESA02230.1 - 0.05 12.2 0.9 0.057 12.0 0.6 1.1 1 0 0 1 1 1 0 FemAB family DUF2935 PF11155.3 ESA02230.1 - 0.052 13.6 0.1 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Nsp1_C PF05064.8 ESA02230.1 - 0.052 13.1 1.6 0.078 12.6 1.1 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region UCR_hinge PF02320.11 ESA02230.1 - 0.053 13.4 0.2 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein V-ATPase_C PF03223.10 ESA02230.1 - 0.054 12.4 1.0 0.07 12.0 0.7 1.1 1 0 0 1 1 1 0 V-ATPase subunit C Paralemmin PF03285.10 ESA02230.1 - 0.06 12.8 1.6 0.076 12.4 1.1 1.4 1 1 0 1 1 1 0 Paralemmin DUF4407 PF14362.1 ESA02230.1 - 0.062 12.2 0.1 0.071 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.6 ESA02230.1 - 0.063 12.7 2.1 0.11 11.9 1.5 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF3287 PF11690.3 ESA02230.1 - 0.065 13.3 0.7 0.1 12.6 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) Cep57_MT_bd PF06657.8 ESA02230.1 - 0.066 13.1 3.9 0.14 12.1 2.7 1.5 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 PilJ PF13675.1 ESA02230.1 - 0.068 13.4 0.1 0.097 12.9 0.1 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term HalX PF08663.5 ESA02230.1 - 0.069 13.1 3.1 0.27 11.2 2.0 1.9 1 1 1 2 2 2 0 HalX domain Fungal_trans_2 PF11951.3 ESA02230.1 - 0.07 11.7 0.1 0.075 11.6 0.1 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4200 PF13863.1 ESA02230.1 - 0.071 13.0 2.8 0.14 12.0 1.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Seryl_tRNA_N PF02403.17 ESA02230.1 - 0.084 12.8 2.0 0.22 11.5 1.4 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DASH_Dad3 PF08656.5 ESA02230.1 - 0.084 12.5 2.3 0.25 11.0 0.3 2.2 1 1 1 2 2 2 0 DASH complex subunit Dad3 Syntaxin PF00804.20 ESA02230.1 - 0.084 13.0 1.8 0.12 12.5 1.3 1.3 1 0 0 1 1 1 0 Syntaxin DUF465 PF04325.8 ESA02230.1 - 0.086 12.5 0.8 0.21 11.3 0.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF465) bZIP_2 PF07716.10 ESA02230.1 - 0.096 12.5 4.7 0.86 9.4 0.9 2.2 1 1 1 2 2 2 0 Basic region leucine zipper MbeD_MobD PF04899.7 ESA02230.1 - 0.098 12.5 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 MbeD/MobD like Prefoldin PF02996.12 ESA02230.1 - 0.1 12.2 2.0 0.25 11.0 0.5 1.8 1 1 0 1 1 1 0 Prefoldin subunit Spc24 PF08286.6 ESA02230.1 - 0.1 12.2 3.7 0.6 9.8 2.5 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 KLRAQ PF10205.4 ESA02230.1 - 0.12 12.4 4.0 0.16 12.0 2.7 1.4 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Snapin_Pallidin PF14712.1 ESA02230.1 - 0.12 12.7 2.8 0.41 10.9 1.1 1.9 1 1 1 2 2 2 0 Snapin/Pallidin DUF4140 PF13600.1 ESA02230.1 - 0.12 12.8 1.4 0.26 11.7 1.0 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Baculo_PEP_C PF04513.7 ESA02230.1 - 0.12 12.1 0.2 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 ESA02230.1 - 0.12 12.4 1.6 0.18 11.9 1.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF972 PF06156.8 ESA02230.1 - 0.13 12.6 2.1 0.27 11.6 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) CorA PF01544.13 ESA02230.1 - 0.14 11.1 1.2 0.2 10.6 0.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Lge1 PF11488.3 ESA02230.1 - 0.14 12.3 2.5 0.29 11.3 1.8 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 MCC-bdg_PDZ PF10506.4 ESA02230.1 - 0.15 11.8 1.7 0.31 10.9 1.2 1.6 1 1 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Herpes_BLRF2 PF05812.7 ESA02230.1 - 0.18 11.6 2.7 0.57 9.9 1.0 2.2 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein DUF2951 PF11166.3 ESA02230.1 - 0.19 11.5 1.4 0.38 10.6 0.4 1.8 1 1 1 2 2 1 0 Protein of unknown function (DUF2951) XhlA PF10779.4 ESA02230.1 - 0.2 11.5 1.9 0.38 10.6 1.3 1.6 1 1 0 1 1 1 0 Haemolysin XhlA EMP24_GP25L PF01105.19 ESA02230.1 - 0.24 11.0 2.4 0.19 11.4 0.7 1.5 2 0 0 2 2 1 0 emp24/gp25L/p24 family/GOLD DUF1049 PF06305.6 ESA02230.1 - 0.28 10.7 2.9 5.8 6.4 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1049) Pox_A_type_inc PF04508.7 ESA02230.1 - 0.29 11.0 5.5 3.5 7.6 2.1 2.7 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat Tnp_P_element PF12017.3 ESA02230.1 - 0.32 10.2 1.7 2.3 7.4 1.1 2.2 1 1 0 1 1 1 0 Transposase protein DUF4446 PF14584.1 ESA02230.1 - 0.45 10.3 2.6 0.2 11.4 0.4 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF4446) Cep57_CLD_2 PF14197.1 ESA02230.1 - 0.61 10.0 6.2 2.5 8.0 0.8 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Val_tRNA-synt_C PF10458.4 ESA02230.1 - 0.97 9.5 3.5 2.2 8.4 0.9 2.2 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm HR1 PF02185.11 ESA02230.1 - 1.1 9.0 5.7 3 7.6 4.0 1.8 1 1 0 1 1 1 0 Hr1 repeat DUF904 PF06005.7 ESA02230.1 - 1.3 9.4 5.4 1.8 8.9 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) FlxA PF14282.1 ESA02230.1 - 1.4 8.9 5.0 0.43 10.5 1.1 2.0 2 1 0 2 2 1 0 FlxA-like protein V-SNARE PF05008.10 ESA02230.1 - 1.7 8.8 5.8 3.1 8.0 0.9 2.3 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Asp_protease_2 PF13650.1 ESA02231.1 - 0.027 14.9 0.0 0.037 14.5 0.0 1.4 1 1 0 1 1 1 0 Aspartyl protease DUF1907 PF08925.6 ESA02232.1 - 0.062 12.3 0.1 0.076 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) DUF4130 PF13566.1 ESA02235.1 - 0.11 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 zf-BED PF02892.10 ESA02236.1 - 3.4e-10 39.5 3.1 5.7e-10 38.8 2.1 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA02236.1 - 0.015 15.5 0.1 0.045 14.0 0.1 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger SWIRM PF04433.12 ESA02238.1 - 8.4e-16 57.8 0.0 2.6e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain JAB PF01398.16 ESA02238.1 - 1.5e-13 50.4 0.0 3.9e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESA02238.1 - 3.1e-09 36.3 0.0 6.3e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF16 PF01519.11 ESA02239.1 - 0.1 12.8 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 Carboxyl_trans PF01039.17 ESA02240.1 - 2.9e-149 497.5 0.1 3.5e-149 497.3 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 ESA02240.1 - 0.0091 15.2 0.4 1.4 8.0 0.0 2.8 3 0 0 3 3 3 2 Malonate decarboxylase gamma subunit (MdcE) BTB PF00651.26 ESA02242.1 - 3.6e-15 55.9 0.0 6.3e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA02242.1 - 0.033 14.0 0.1 2.6 7.9 0.0 2.4 1 1 1 2 2 2 0 BTB And C-terminal Kelch IBD PF10416.4 ESA02245.1 - 0.16 11.7 1.0 1.5 8.6 0.1 2.2 2 0 0 2 2 2 0 Transcription-initiator DNA-binding domain IBD Sel1 PF08238.7 ESA02248.1 - 5.7e-14 52.2 0.9 7.5e-14 51.8 0.6 1.2 1 0 0 1 1 1 1 Sel1 repeat TPR_20 PF14561.1 ESA02248.1 - 0.046 13.8 0.1 0.054 13.6 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA02248.1 - 0.055 13.9 0.4 0.16 12.4 0.2 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat GRAM PF02893.15 ESA02249.1 - 5.9e-19 67.3 0.4 2.4e-18 65.3 0.2 2.1 2 0 0 2 2 2 1 GRAM domain DUF912 PF06024.7 ESA02249.1 - 0.0078 16.2 0.6 0.0078 16.2 0.4 2.4 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) EMP24_GP25L PF01105.19 ESA02249.1 - 0.023 14.4 4.6 0.019 14.6 1.7 2.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4519 PF15012.1 ESA02249.1 - 0.73 9.7 4.2 2.2 8.2 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) F-box-like PF12937.2 ESA02250.1 - 1.5e-08 34.2 4.1 4.5e-08 32.6 2.8 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA02250.1 - 0.00026 20.5 1.8 0.0009 18.8 1.3 2.0 1 0 0 1 1 1 1 F-box domain DUF4538 PF15061.1 ESA02250.1 - 0.097 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) HSP70 PF00012.15 ESA02251.1 - 8.3e-06 23.9 3.5 8.8e-06 23.9 0.1 2.4 3 1 0 3 3 3 1 Hsp70 protein MreB_Mbl PF06723.8 ESA02251.1 - 3.1e-05 22.7 0.0 0.033 12.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein ACC_central PF08326.7 ESA02254.1 - 6.1e-234 778.3 0.1 8.2e-234 777.8 0.1 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 ESA02254.1 - 8.3e-174 578.5 0.0 1.2e-173 578.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 ESA02254.1 - 1.7e-54 184.2 0.0 5.4e-54 182.6 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESA02254.1 - 4.5e-25 87.8 0.3 1.3e-24 86.3 0.1 2.0 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESA02254.1 - 4.9e-21 74.7 0.0 4.7e-20 71.5 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 ESA02254.1 - 2.4e-15 55.9 0.0 4.9e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 ESA02254.1 - 9e-13 48.3 0.3 2.2e-11 43.8 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESA02254.1 - 7.9e-07 28.1 0.0 9.7e-05 21.2 0.0 3.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 ESA02254.1 - 9.9e-05 21.8 0.0 0.00022 20.6 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 ESA02254.1 - 0.00019 21.3 0.0 0.00098 19.0 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 ESA02254.1 - 0.00026 20.5 0.1 0.0026 17.3 0.0 2.7 3 0 0 3 3 3 1 Biotin-lipoyl like ATP-grasp PF02222.17 ESA02254.1 - 0.0019 17.5 0.1 0.0051 16.1 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.1 ESA02254.1 - 0.081 12.6 0.0 0.62 9.8 0.0 2.3 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain RabGAP-TBC PF00566.13 ESA02256.1 - 6.1e-41 140.2 7.2 1e-40 139.5 5.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Kelch_5 PF13854.1 ESA02257.1 - 1.3e-19 69.7 2.2 3.6e-08 33.1 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA02257.1 - 7.7e-17 60.9 9.2 0.00047 20.2 0.0 5.8 5 2 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA02257.1 - 3e-16 58.8 2.2 6e-05 22.7 0.0 5.1 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA02257.1 - 8.6e-12 44.7 2.9 0.00029 20.8 0.0 4.3 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA02257.1 - 1.1e-11 44.1 0.8 3.8e-06 26.3 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA02257.1 - 1.7e-09 37.0 0.2 0.0071 16.0 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Exo_endo_phos PF03372.18 ESA02258.1 - 6.4e-14 52.4 0.0 8.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DDE_3 PF13358.1 ESA02259.1 - 1.6e-05 24.6 0.9 2.4e-05 24.1 0.2 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA02260.1 - 0.036 13.8 0.0 0.037 13.7 0.0 1.0 1 0 0 1 1 1 0 DDE superfamily endonuclease Pkinase PF00069.20 ESA02261.1 - 1.4e-16 60.4 0.5 2.1e-16 59.8 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02261.1 - 4.6e-11 42.2 0.2 7e-11 41.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PHB_acc_N PF07879.6 ESA02262.1 - 0.13 11.9 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain BTB PF00651.26 ESA02263.1 - 1.3e-13 50.9 0.3 2.7e-13 49.8 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02263.1 - 9.4e-12 45.1 1.2 2.7e-11 43.6 0.1 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02263.1 - 9.3e-07 28.6 0.5 3.2e-06 26.9 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Corona_nucleoca PF00937.13 ESA02263.1 - 0.29 10.0 5.5 0.42 9.4 3.8 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein BTB PF00651.26 ESA02264.1 - 5.9e-19 68.1 0.0 1.1e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02264.1 - 3.7e-17 62.6 0.6 9.2e-17 61.3 0.4 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02264.1 - 3.5e-09 36.4 8.3 1.7e-08 34.2 0.5 4.2 1 1 3 4 4 4 1 BTB And C-terminal Kelch Sec61_beta PF03911.11 ESA02265.1 - 3e-19 68.5 0.4 4.1e-19 68.0 0.3 1.2 1 0 0 1 1 1 1 Sec61beta family Calcyon PF06387.6 ESA02265.1 - 0.04 13.2 0.0 0.042 13.2 0.0 1.1 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Nramp PF01566.13 ESA02266.1 - 1.5e-112 375.9 23.2 2.1e-112 375.5 16.1 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Peptidase_C54 PF03416.14 ESA02267.1 - 1.6e-96 322.7 0.0 2.2e-96 322.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 DUF2045 PF09741.4 ESA02268.1 - 5.9e-45 153.2 0.0 8.8e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) DUF3955 PF13127.1 ESA02269.1 - 1.6 8.3 8.7 1.5 8.4 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3955) V-set_CD47 PF08204.6 ESA02271.1 - 0.11 12.2 0.2 0.11 12.3 0.2 1.1 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Herpes_Helicase PF02689.9 ESA02272.1 - 0.0083 13.9 0.0 0.011 13.5 0.0 1.3 1 1 0 1 1 1 1 Helicase CBM49 PF09478.5 ESA02272.1 - 0.047 13.7 1.5 0.048 13.7 0.5 1.6 1 1 1 2 2 2 0 Carbohydrate binding domain CBM49 ubiquitin PF00240.18 ESA02273.1 - 6.5e-12 44.6 0.0 1.2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA02273.1 - 2.7e-07 30.1 0.1 4.1e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ESA02273.1 - 5.5e-05 22.6 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ubiquitin_2 PF14560.1 ESA02273.1 - 0.053 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain DUF3990 PF13151.1 ESA02273.1 - 0.29 10.5 1.6 0.64 9.3 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3990) NPV_P10 PF05531.7 ESA02277.1 - 0.074 13.3 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Dimer_Tnp_hAT PF05699.9 ESA02278.1 - 2.1e-23 81.7 0.2 2.2e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2291 PF10054.4 ESA02280.1 - 0.068 12.4 0.0 0.068 12.4 0.0 1.0 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) PX PF00787.19 ESA02281.1 - 1.6e-16 60.0 0.1 1.8e-16 59.9 0.1 1.0 1 0 0 1 1 1 1 PX domain Fumble PF03630.9 ESA02283.1 - 1.3e-133 445.1 4.9 4.4e-132 440.0 2.4 2.4 2 1 0 2 2 2 1 Fumble DUF89 PF01937.14 ESA02283.1 - 2.5e-46 158.1 1.2 3.5e-46 157.6 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF89 Ribosomal_L18_c PF14204.1 ESA02284.1 - 0.008 16.7 2.9 0.012 16.2 2.0 1.3 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region SPT2 PF08243.6 ESA02284.1 - 0.041 14.1 0.8 0.056 13.7 0.6 1.3 1 1 0 1 1 1 0 SPT2 chromatin protein DUF4628 PF15429.1 ESA02284.1 - 0.14 11.5 1.8 0.16 11.3 1.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4628) YtxH PF12732.2 ESA02284.1 - 0.64 10.4 3.7 3.7 7.9 0.6 2.2 2 0 0 2 2 2 0 YtxH-like protein 7tm_1 PF00001.16 ESA02285.1 - 3.4e-05 23.1 3.7 4.5e-05 22.7 2.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.6 ESA02285.1 - 4.4e-05 22.5 3.9 7e-05 21.8 2.7 1.4 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor STE3 PF02076.10 ESA02286.1 - 0.00047 19.3 14.9 0.11 11.5 6.1 3.1 2 2 0 2 2 2 2 Pheromone A receptor RRM_1 PF00076.17 ESA02289.1 - 1.6e-12 46.8 0.0 2.2e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02289.1 - 2.2e-09 37.0 0.0 2.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02289.1 - 2.1e-08 33.9 0.0 3.1e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA02289.1 - 0.081 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Kinesin PF00225.18 ESA02295.1 - 4.8e-49 166.8 4.2 3.9e-48 163.8 2.9 2.1 1 1 0 1 1 1 1 Kinesin motor domain AAA_10 PF12846.2 ESA02295.1 - 0.11 11.9 0.7 0.16 11.3 0.5 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 ESA02295.1 - 0.13 12.4 0.5 0.32 11.1 0.3 1.8 1 1 0 1 1 1 0 AAA domain Kinesin PF00225.18 ESA02297.1 - 1.4e-14 53.5 0.2 1.8e-14 53.2 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Glyco_tran_28_C PF04101.11 ESA02297.1 - 0.062 12.9 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain PIF1 PF05970.9 ESA02298.1 - 0.11 11.4 0.0 0.11 11.4 0.0 1.0 1 0 0 1 1 1 0 PIF1-like helicase 7TM_GPCR_Str PF10326.4 ESA02300.1 - 0.0059 15.7 0.2 0.0093 15.1 0.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Str zf-FCS PF06467.9 ESA02300.1 - 0.11 12.1 5.8 0.22 11.1 0.6 2.5 2 1 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif IBR PF01485.16 ESA02300.1 - 1.9 8.4 13.6 2.4e+02 1.6 9.4 2.4 1 1 0 1 1 1 0 IBR domain DUF1242 PF06842.7 ESA02301.1 - 0.53 9.8 5.5 0.64 9.5 3.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1242) zf-FCS PF06467.9 ESA02301.1 - 2.4 7.8 10.6 0.37 10.4 0.6 3.2 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif FANCL_C PF11793.3 ESA02301.1 - 9 6.3 10.8 19 5.3 4.7 2.8 1 1 1 2 2 2 0 FANCL C-terminal domain EB1 PF03271.12 ESA02302.1 - 0.031 14.3 0.1 0.33 11.0 0.0 2.2 2 0 0 2 2 2 0 EB1-like C-terminal motif Haem_oxygenas_2 PF14518.1 ESA02303.1 - 5.3e-14 52.2 0.1 1.6e-13 50.7 0.0 1.9 2 0 0 2 2 2 1 Iron-containing redox enzyme PSCyt1 PF07635.6 ESA02303.1 - 0.0057 16.9 0.0 14 6.1 0.0 3.4 3 0 0 3 3 3 2 Planctomycete cytochrome C Antistasin PF02822.9 ESA02304.1 - 0.12 12.6 1.2 0.12 12.6 0.9 3.1 2 1 1 3 3 3 0 Antistasin family eIF3g PF12353.3 ESA02304.1 - 0.45 10.4 3.2 0.58 10.0 2.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Arc_trans_TRASH PF08394.5 ESA02304.1 - 1.1 9.4 17.0 0.1 12.7 2.7 2.8 1 1 2 3 3 3 0 Archaeal TRASH domain DUF329 PF03884.9 ESA02304.1 - 9.3 5.8 13.2 1.7 8.2 0.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF329) zf-FCS PF06467.9 ESA02304.1 - 9.7 5.9 19.1 0.39 10.4 2.1 3.2 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif F-box-like PF12937.2 ESA02306.1 - 0.04 13.6 0.7 0.13 12.0 0.5 1.9 1 0 0 1 1 1 0 F-box-like zf-RING_2 PF13639.1 ESA02307.1 - 5.2e-12 45.4 5.6 1.1e-11 44.3 3.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA02307.1 - 6.4e-07 28.9 3.7 1.5e-06 27.7 2.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA02307.1 - 1.5e-06 28.1 1.1 4.6e-06 26.6 0.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA02307.1 - 1.9e-06 27.8 5.3 4.9e-06 26.4 3.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA02307.1 - 1.3e-05 24.8 1.7 3e-05 23.6 1.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA02307.1 - 0.00015 21.3 0.6 0.00032 20.3 0.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA02307.1 - 0.0025 17.6 1.5 0.0063 16.3 1.1 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 ESA02307.1 - 0.0045 16.5 3.6 0.0099 15.4 2.5 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain adh_short_C2 PF13561.1 ESA02308.1 - 3.1e-32 112.2 0.5 3.6e-32 112.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 ESA02308.1 - 3.7e-23 82.2 0.2 4.8e-23 81.8 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA02308.1 - 3.4e-07 30.1 0.0 6.9e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 KR domain Spheroidin PF05541.7 ESA02308.1 - 0.012 13.3 0.2 0.015 12.9 0.1 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein Ribonuc_L-PSP PF01042.16 ESA02309.1 - 9.5e-47 157.7 0.3 1.1e-46 157.5 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Rab3-GTPase_cat PF13890.1 ESA02309.1 - 0.039 13.3 0.0 0.048 13.0 0.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit BPL_N PF09825.4 ESA02310.1 - 0.00018 20.4 0.0 0.0002 20.2 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_N PF09825.4 ESA02311.1 - 0.00075 18.3 0.4 0.00085 18.2 0.3 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal TctC PF03401.9 ESA02311.1 - 0.13 11.2 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor SPRY PF00622.23 ESA02312.1 - 1.8e-15 57.1 0.1 8.1e-14 51.7 0.1 2.8 2 0 0 2 2 2 1 SPRY domain PHD PF00628.24 ESA02312.1 - 1.5e-06 27.7 7.2 3.1e-06 26.7 5.0 1.5 1 0 0 1 1 1 1 PHD-finger RINGv PF12906.2 ESA02312.1 - 0.51 10.4 6.7 1.2 9.2 4.6 1.7 1 0 0 1 1 1 0 RING-variant domain Ribosomal_L36e PF01158.13 ESA02313.1 - 2.3e-42 142.9 6.7 2.6e-42 142.7 4.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e LemA PF04011.7 ESA02313.1 - 0.002 17.2 0.3 0.0023 17.0 0.2 1.2 1 0 0 1 1 1 1 LemA family 4HB_MCP_1 PF12729.2 ESA02313.1 - 0.0049 16.2 0.1 0.0064 15.8 0.1 1.1 1 0 0 1 1 1 1 Four helix bundle sensory module for signal transduction Ricin_B_lectin PF00652.17 ESA02314.1 - 2e-10 40.7 0.1 3.2e-06 27.1 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 ESA02314.1 - 4.1e-08 33.5 0.5 0.00058 20.2 0.1 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Reprolysin_2 PF13574.1 ESA02314.1 - 0.075 13.0 0.0 0.087 12.8 0.0 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF1672 PF07901.6 ESA02315.1 - 0.023 13.6 0.8 0.026 13.5 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Cse1 PF08506.5 ESA02315.1 - 0.024 13.1 0.3 0.027 13.0 0.2 1.2 1 0 0 1 1 1 0 Cse1 HATPase_c_3 PF13589.1 ESA02316.1 - 9.7e-06 25.2 0.4 0.0034 17.0 0.0 3.4 2 2 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glucosamine_iso PF01182.15 ESA02318.1 - 4e-39 134.4 0.0 4.3e-23 82.0 0.0 2.1 1 1 1 2 2 2 2 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Zip PF02535.17 ESA02319.1 - 2e-59 201.1 9.4 1.3e-57 195.1 6.5 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1705 PF08019.7 ESA02319.1 - 0.013 14.9 0.5 0.039 13.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1705) DMP1 PF07263.6 ESA02319.1 - 0.017 13.8 1.7 0.024 13.3 1.2 1.1 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) CCDC-167 PF15188.1 ESA02319.1 - 0.046 13.6 0.1 13 5.8 0.0 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 YABBY PF04690.8 ESA02320.1 - 3.3e-09 37.2 0.6 3.4e-09 37.1 0.4 1.1 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.14 ESA02320.1 - 6.6e-06 26.3 1.6 1e-05 25.6 1.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF1014 PF06244.7 ESA02320.1 - 1.5e-05 25.2 6.2 1.7e-05 24.9 4.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) HMG_box_2 PF09011.5 ESA02320.1 - 0.00081 19.7 1.3 0.00081 19.7 0.9 1.4 1 1 0 1 1 1 1 HMG-box domain Chitin_synth_2 PF03142.10 ESA02321.1 - 5.9e-255 846.6 0.0 1e-254 845.8 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA02321.1 - 1.2e-15 57.7 6.4 7.8e-15 55.0 4.5 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA02321.1 - 1.8e-15 57.4 0.0 1.4e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 ESA02321.1 - 1.2e-06 28.2 0.1 9.3e-05 22.1 0.0 2.6 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 ESA02321.1 - 0.0044 16.3 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_4 PF00953.16 ESA02322.1 - 2.1e-33 115.3 17.7 2.1e-33 115.3 12.3 2.4 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF3820 PF12843.2 ESA02322.1 - 0.091 12.3 0.4 3.2 7.4 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3820) DASH_Dad4 PF08650.5 ESA02323.1 - 4.6e-21 74.4 6.1 5.2e-21 74.3 4.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DUF2205 PF10224.4 ESA02323.1 - 0.0024 17.4 1.1 0.0027 17.2 0.8 1.2 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) ParB PF08775.5 ESA02323.1 - 0.019 15.2 0.0 0.02 15.1 0.0 1.0 1 0 0 1 1 1 0 ParB family MscS_porin PF12795.2 ESA02323.1 - 0.03 13.6 0.2 0.039 13.2 0.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain SusD-like_3 PF14322.1 ESA02323.1 - 0.035 14.1 0.9 0.034 14.2 0.6 1.0 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Laminin_I PF06008.9 ESA02323.1 - 0.036 13.3 0.9 0.041 13.1 0.6 1.1 1 0 0 1 1 1 0 Laminin Domain I COG6 PF06419.6 ESA02323.1 - 0.047 11.8 0.5 0.054 11.6 0.3 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 DUF3832 PF12909.2 ESA02323.1 - 0.053 13.5 0.3 0.066 13.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3832) SNARE PF05739.14 ESA02323.1 - 0.069 12.8 2.6 0.13 11.9 1.8 1.4 1 0 0 1 1 1 0 SNARE domain Syntaxin_2 PF14523.1 ESA02323.1 - 0.082 12.9 0.2 0.093 12.7 0.1 1.2 1 0 0 1 1 1 0 Syntaxin-like protein Snapin_Pallidin PF14712.1 ESA02323.1 - 0.093 13.0 0.9 0.1 12.8 0.6 1.3 1 1 0 1 1 1 0 Snapin/Pallidin DASH_Dad1 PF08649.5 ESA02323.1 - 0.13 11.9 5.3 0.14 11.9 3.2 1.4 1 1 0 1 1 1 0 DASH complex subunit Dad1 Matrilin_ccoil PF10393.4 ESA02323.1 - 0.14 11.5 0.3 0.29 10.5 0.1 1.6 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Hemagglutinin PF00509.13 ESA02323.1 - 0.16 10.1 2.0 0.17 9.9 1.4 1.0 1 0 0 1 1 1 0 Haemagglutinin TPR_MLP1_2 PF07926.7 ESA02323.1 - 0.93 9.2 4.8 3.8 7.2 2.9 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Costars PF14705.1 ESA02324.1 - 0.085 12.8 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Costars UBN2_2 PF14227.1 ESA02324.1 - 0.11 12.1 2.4 0.16 11.5 0.1 2.3 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type HEAT PF02985.17 ESA02325.1 - 2e-18 64.7 2.7 0.13 12.4 0.0 7.6 7 0 0 7 7 7 6 HEAT repeat HEAT_2 PF13646.1 ESA02325.1 - 3.3e-16 59.3 0.0 7.9e-06 26.0 0.0 4.5 2 2 3 5 5 5 4 HEAT repeats Cnd1 PF12717.2 ESA02325.1 - 1.4e-07 31.5 10.7 6.5e-06 26.1 0.1 4.0 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 ESA02325.1 - 0.00013 21.4 0.4 3.5 6.9 0.0 4.2 2 2 1 4 4 4 2 CLASP N terminal DUF3843 PF12954.2 ESA02325.1 - 0.0005 19.2 0.0 0.0011 18.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3843) Cohesin_HEAT PF12765.2 ESA02325.1 - 0.00095 19.0 1.3 8.4 6.4 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.1 ESA02325.1 - 0.0022 18.4 0.5 1.6 9.2 0.1 4.6 5 1 1 6 6 6 1 HEAT-like repeat Cnd3 PF12719.2 ESA02325.1 - 0.0061 15.5 4.0 0.76 8.7 0.2 3.0 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain UCH PF00443.24 ESA02326.1 - 1.8e-55 187.9 4.4 3.1e-55 187.1 1.9 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA02326.1 - 6.3e-25 88.2 2.3 6.3e-25 88.2 1.6 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ustilago_mating PF05722.7 ESA02326.1 - 0.019 14.2 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein TAN PF11640.3 ESA02326.1 - 0.02 14.6 1.4 0.46 10.2 0.1 3.4 4 0 0 4 4 4 0 Telomere-length maintenance and DNA damage repair Ribosomal_S17e PF00833.13 ESA02326.1 - 0.068 12.9 0.1 0.94 9.2 0.0 2.5 2 0 0 2 2 2 0 Ribosomal S17 Fis1_TPR_C PF14853.1 ESA02327.1 - 6.2e-24 83.6 1.7 8.8e-24 83.1 1.2 1.2 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 ESA02327.1 - 1.5e-12 46.6 0.0 2.5e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.12 ESA02327.1 - 0.0089 15.8 0.6 0.016 15.1 0.4 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA02327.1 - 0.026 14.8 0.4 0.045 14.0 0.3 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TMF_DNA_bd PF12329.3 ESA02329.1 - 0.1 12.4 7.7 0.14 12.0 1.0 3.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESA02329.1 - 0.15 11.5 6.4 0.5 9.8 1.1 3.1 2 0 0 2 2 2 0 Septum formation initiator Spectrin PF00435.16 ESA02329.1 - 1.7 8.9 9.2 8.4 6.7 0.4 3.6 2 1 1 3 3 3 0 Spectrin repeat FlxA PF14282.1 ESA02329.1 - 1.8 8.5 19.3 12 5.8 2.7 4.2 3 2 0 3 3 3 0 FlxA-like protein Shugoshin_N PF07558.6 ESA02329.1 - 3.9 7.2 13.6 5.8 6.7 1.0 4.1 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region DUF3650 PF12368.3 ESA02330.1 - 0.018 14.5 2.1 4.5 6.8 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3650) Phospholip_A2_2 PF05826.7 ESA02331.1 - 0.0098 15.8 0.5 0.014 15.3 0.4 1.4 1 0 0 1 1 1 1 Phospholipase A2 ATG16 PF08614.6 ESA02331.1 - 0.017 14.9 1.5 0.017 14.9 1.0 1.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF535 PF04393.8 ESA02331.1 - 0.044 12.6 0.2 0.054 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF535) bZIP_1 PF00170.16 ESA02331.1 - 0.054 13.4 3.3 1.9 8.5 1.3 2.5 1 1 1 2 2 2 0 bZIP transcription factor Striatin PF08232.7 ESA02331.1 - 0.092 13.0 1.6 0.11 12.8 0.5 1.5 1 1 0 1 1 1 0 Striatin family DUF2272 PF10030.4 ESA02331.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) Dict-STAT-coil PF09267.5 ESA02331.1 - 0.12 12.5 0.1 0.34 11.1 0.0 1.7 1 1 1 2 2 2 0 Dictyostelium STAT, coiled coil DUF3287 PF11690.3 ESA02331.1 - 0.48 10.5 3.2 0.39 10.8 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) Acylphosphatase PF00708.13 ESA02332.1 - 0.041 13.9 0.0 0.084 12.9 0.0 1.5 1 1 0 1 1 1 0 Acylphosphatase Cullin PF00888.17 ESA02332.1 - 0.11 10.9 0.0 0.15 10.5 0.0 1.1 1 0 0 1 1 1 0 Cullin family MutS_II PF05188.12 ESA02333.1 - 0.074 13.1 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 MutS domain II GP41 PF00517.12 ESA02334.1 - 0.0041 16.7 0.0 0.0055 16.2 0.0 1.1 1 0 0 1 1 1 1 Retroviral envelope protein Striatin PF08232.7 ESA02334.1 - 0.011 16.0 1.2 0.029 14.7 0.8 1.7 1 1 0 1 1 1 0 Striatin family Phospholip_A2_2 PF05826.7 ESA02334.1 - 0.022 14.6 0.5 0.032 14.1 0.3 1.3 1 0 0 1 1 1 0 Phospholipase A2 Fmp27_WPPW PF10359.4 ESA02334.1 - 0.024 13.0 2.3 0.027 12.8 1.6 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain EzrA PF06160.7 ESA02334.1 - 0.052 11.7 0.3 0.059 11.5 0.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA FliD_C PF07195.7 ESA02334.1 - 0.063 12.5 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CENP-Q PF13094.1 ESA02334.1 - 0.21 11.5 1.6 0.26 11.2 1.1 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_S8 PF00082.17 ESA02336.1 - 2.6e-54 184.3 1.6 3.4e-54 183.9 1.1 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA02336.1 - 2.9e-15 56.6 1.1 5.7e-15 55.6 0.8 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 XPG_I PF00867.13 ESA02337.1 - 9.7e-18 64.0 0.0 2.8e-17 62.5 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ESA02337.1 - 3.3e-16 59.3 0.1 4.7e-15 55.6 0.1 2.3 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.15 ESA02337.1 - 7.4e-07 29.3 0.2 8.1e-06 25.9 0.0 2.5 2 1 1 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.2 ESA02337.1 - 0.0014 18.4 0.0 0.0034 17.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif XAP5 PF04921.9 ESA02337.1 - 0.012 15.1 0.3 0.02 14.4 0.2 1.5 1 1 0 1 1 1 0 XAP5, circadian clock regulator Thioredoxin_6 PF13848.1 ESA02337.1 - 0.098 12.4 2.4 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain FTHFS PF01268.14 ESA02338.1 - 1.5e-255 848.4 0.0 2e-255 848.0 0.0 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 ESA02338.1 - 1e-67 226.2 1.4 1.2e-67 225.9 0.1 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 ESA02338.1 - 6.9e-41 138.9 1.0 7.2e-40 135.6 0.5 2.5 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Pkinase PF00069.20 ESA02339.1 - 4.2e-71 239.1 0.1 8.2e-71 238.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02339.1 - 3.1e-36 124.7 0.0 4.5e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA02339.1 - 0.012 14.6 0.0 0.022 13.7 0.0 1.6 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA02339.1 - 0.085 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PG_binding_2 PF08823.6 ESA02341.1 - 0.053 13.6 0.2 0.053 13.6 0.1 2.8 3 0 0 3 3 3 0 Putative peptidoglycan binding domain Neur_chan_memb PF02932.11 ESA02341.1 - 0.78 9.5 5.0 0.96 9.2 3.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDRGK PF09756.4 ESA02341.1 - 1.1 8.6 10.2 2.1 7.6 7.1 1.5 1 0 0 1 1 1 0 DDRGK domain Ndc1_Nup PF09531.5 ESA02341.1 - 3.6 5.8 7.0 4.8 5.4 4.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Nucleoplasmin PF03066.10 ESA02342.1 - 2.4 7.6 4.5 2.6 7.5 3.1 1.1 1 0 0 1 1 1 0 Nucleoplasmin NYN PF01936.13 ESA02343.1 - 2e-12 47.6 0.0 3.6e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 NYN domain Mg-por_mtran_C PF07109.6 ESA02345.1 - 0.054 13.5 0.0 0.24 11.4 0.0 2.0 2 1 0 2 2 2 0 Magnesium-protoporphyrin IX methyltransferase C-terminus GSG-1 PF07803.6 ESA02348.1 - 0.062 12.8 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 GSG1-like protein LTV PF04180.9 ESA02351.1 - 0.032 13.7 0.3 0.032 13.7 0.2 1.0 1 0 0 1 1 1 0 Low temperature viability protein LURAP PF14854.1 ESA02351.1 - 0.15 11.8 6.6 0.2 11.3 4.6 1.3 1 1 0 1 1 1 0 Leucine rich adaptor protein Dysbindin PF04440.11 ESA02351.1 - 0.37 10.5 2.6 0.85 9.3 1.8 1.6 1 1 0 1 1 1 0 Dysbindin (Dystrobrevin binding protein 1) GCV_T PF01571.16 ESA02352.1 - 8.4e-66 221.3 0.0 1.1e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESA02352.1 - 3.2e-25 87.9 0.1 6e-25 87.1 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.7 ESA02352.1 - 0.00027 20.7 0.0 0.039 13.8 0.0 2.2 2 0 0 2 2 2 2 Sarcosine oxidase, gamma subunit family DUF2401 PF10287.4 ESA02352.1 - 0.091 12.2 0.1 2.2 7.6 0.0 2.1 2 0 0 2 2 2 0 Putative TOS1-like glycosyl hydrolase (DUF2401) WD40 PF00400.27 ESA02353.1 - 6.1e-16 57.6 9.6 5.8e-05 22.8 0.3 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Dynein_IC2 PF11540.3 ESA02353.1 - 3.8e-05 22.9 0.1 8.4e-05 21.8 0.0 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 NPV_P10 PF05531.7 ESA02354.1 - 0.018 15.2 4.0 0.032 14.4 1.8 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein LOH1CR12 PF10158.4 ESA02354.1 - 0.044 13.5 0.8 0.06 13.1 0.5 1.3 1 0 0 1 1 1 0 Tumour suppressor protein BLOC1_2 PF10046.4 ESA02354.1 - 0.053 13.6 10.0 0.097 12.8 6.6 1.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Colicin PF01024.14 ESA02354.1 - 0.091 12.3 2.8 0.11 12.0 2.0 1.1 1 0 0 1 1 1 0 Colicin pore forming domain DASH_Dam1 PF08653.5 ESA02354.1 - 0.15 11.7 2.4 0.24 11.1 1.4 1.6 1 1 0 1 1 1 0 DASH complex subunit Dam1 FTA4 PF13093.1 ESA02354.1 - 0.23 10.8 9.4 0.28 10.5 6.5 1.0 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 PNK3P PF08645.6 ESA02354.1 - 0.25 10.7 1.9 0.31 10.4 1.3 1.1 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase tRNA-synt_His PF13393.1 ESA02354.1 - 0.28 10.2 2.9 0.29 10.1 2.0 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase Ead_Ea22 PF13935.1 ESA02354.1 - 0.28 11.4 5.3 0.33 11.2 3.7 1.1 1 0 0 1 1 1 0 Ead/Ea22-like protein FliD_N PF02465.13 ESA02354.1 - 0.35 11.2 1.9 0.49 10.7 1.1 1.5 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF3201 PF11447.3 ESA02354.1 - 0.39 10.1 5.8 0.63 9.4 4.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3201) AAA_23 PF13476.1 ESA02354.1 - 0.53 10.5 19.0 0.64 10.3 13.2 1.1 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.14 ESA02354.1 - 0.71 7.6 7.1 0.77 7.5 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AHH PF14412.1 ESA02354.1 - 0.87 9.6 3.6 1.8 8.5 2.5 1.5 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH CDC37_N PF03234.9 ESA02354.1 - 0.99 9.6 11.7 2.6 8.3 8.1 1.7 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding MerR-DNA-bind PF09278.6 ESA02354.1 - 1.2 9.5 6.6 1.1 9.6 3.0 2.2 2 1 0 2 2 2 0 MerR, DNA binding DUF607 PF04678.8 ESA02354.1 - 2.4 8.0 6.1 3.8 7.4 4.2 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF607 DUF4375 PF14300.1 ESA02354.1 - 2.6 8.0 10.3 3.1 7.8 5.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) RRF_GI PF12614.3 ESA02354.1 - 2.7 7.8 9.6 12 5.6 6.7 1.9 1 1 0 1 1 1 0 Ribosome recycling factor CK2S PF15011.1 ESA02354.1 - 2.8 7.7 8.6 8.8 6.0 5.9 1.8 1 1 1 2 2 2 0 Casein Kinase 2 substrate DUF4298 PF14131.1 ESA02354.1 - 3.1 7.7 10.6 0.6 10.0 2.8 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4298) DUF2361 PF10153.4 ESA02354.1 - 3.7 7.7 11.6 4.3 7.5 8.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2361) DUF4140 PF13600.1 ESA02354.1 - 4 7.9 5.4 5.3 7.5 3.3 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF3744 PF12558.3 ESA02354.1 - 4.8 7.7 10.1 2.7 8.5 5.4 1.7 1 1 0 1 1 1 0 ATP-binding cassette cobalt transporter DUF3571 PF12095.3 ESA02354.1 - 5.3 7.3 9.9 3.8 7.7 5.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3571) EMP24_GP25L PF01105.19 ESA02354.1 - 6 6.5 6.7 6.8 6.3 4.6 1.3 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fzo_mitofusin PF04799.8 ESA02354.1 - 6.1 6.1 7.5 8.9 5.6 4.8 1.5 1 1 0 1 1 1 0 fzo-like conserved region DUF870 PF05912.6 ESA02356.1 - 0.015 15.0 0.5 0.056 13.2 0.1 1.8 2 0 0 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF870) Ribosomal_L33 PF00471.15 ESA02356.1 - 0.3 11.3 1.8 0.71 10.1 0.2 2.1 2 0 0 2 2 2 0 Ribosomal protein L33 Pox_D5 PF03288.11 ESA02357.1 - 0.0054 16.9 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 Poxvirus D5 protein-like DUF4162 PF13732.1 ESA02358.1 - 0.08 13.4 0.0 0.091 13.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) Na_Ala_symp PF01235.12 ESA02359.1 - 0.0031 16.1 0.1 0.0031 16.1 0.1 1.1 1 0 0 1 1 1 1 Sodium:alanine symporter family DUF2660 PF10859.3 ESA02359.1 - 0.24 11.6 1.6 0.97 9.6 1.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2660) An_peroxidase PF03098.10 ESA02360.1 - 1.3e-33 116.2 0.1 1.3e-33 116.2 0.1 1.6 2 0 0 2 2 2 1 Animal haem peroxidase DOMON PF03351.12 ESA02360.1 - 7.9e-13 48.4 2.9 2.4e-12 46.8 2.0 1.9 1 0 0 1 1 1 1 DOMON domain NAD_binding_1 PF00175.16 ESA02360.1 - 6.3e-12 46.0 0.0 3.2e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESA02360.1 - 1.7e-11 44.1 0.0 4.7e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 ESA02360.1 - 1.2e-10 40.9 0.1 2.9e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.7 ESA02360.1 - 7.9e-07 29.1 1.7 0.018 14.9 0.0 3.4 3 0 0 3 3 3 2 Ferric reductase NAD binding domain Cytochrom_B561 PF03188.11 ESA02360.1 - 4e-05 23.4 12.1 9.8e-05 22.2 8.4 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.4 ESA02360.1 - 0.00047 19.7 5.1 0.00079 18.9 2.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) Myb_DNA-bind_6 PF13921.1 ESA02362.1 - 0.0017 18.3 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA02362.1 - 0.018 15.1 0.1 0.05 13.6 0.1 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain Y_phosphatase PF00102.22 ESA02363.1 - 3.9e-72 242.3 0.1 4.7e-72 242.1 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESA02363.1 - 0.00058 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 ESA02363.1 - 0.021 14.4 0.0 0.058 12.9 0.0 1.8 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain B2 PF11473.3 ESA02363.1 - 0.069 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA binding protein B2 PMI_typeI PF01238.16 ESA02364.1 - 0.12 11.3 0.1 0.13 11.1 0.0 1.0 1 0 0 1 1 1 0 Phosphomannose isomerase type I Cys_rich_VLP PF14194.1 ESA02366.1 - 0.022 14.4 0.3 0.044 13.5 0.2 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP ALS2CR8 PF15299.1 ESA02368.1 - 0.047 13.2 0.7 0.062 12.8 0.4 1.2 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 GAF PF01590.21 ESA02368.1 - 0.055 13.5 0.0 0.069 13.2 0.0 1.2 1 0 0 1 1 1 0 GAF domain CENP-B_dimeris PF09026.5 ESA02368.1 - 0.097 12.9 0.1 0.097 12.9 0.0 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3104 PF11302.3 ESA02368.1 - 0.14 11.5 0.3 0.27 10.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) DUF2706 PF10913.3 ESA02369.1 - 0.17 11.5 1.0 0.35 10.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) DUF3861 PF12977.2 ESA02369.1 - 0.52 10.4 4.2 0.99 9.5 0.8 2.2 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Pox_D5 PF03288.11 ESA02370.1 - 4.3e-05 23.7 0.0 0.00012 22.2 0.0 1.8 1 0 0 1 1 1 1 Poxvirus D5 protein-like RFX_DNA_binding PF02257.10 ESA02370.1 - 0.024 14.7 0.1 0.087 12.9 0.0 1.9 2 0 0 2 2 2 0 RFX DNA-binding domain DUF134 PF02001.11 ESA02371.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF134 Pox_D5 PF03288.11 ESA02372.1 - 1.9e-07 31.2 0.0 5.2e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Poxvirus D5 protein-like RFX_DNA_binding PF02257.10 ESA02372.1 - 0.032 14.3 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 RFX DNA-binding domain Pkinase_Tyr PF07714.12 ESA02373.1 - 1.3e-33 116.1 0.0 2e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02373.1 - 5.1e-28 97.9 2.4 6.3e-28 97.6 0.0 2.2 3 1 0 3 3 3 1 Protein kinase domain APH PF01636.18 ESA02373.1 - 0.0052 16.5 0.0 0.0084 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA02373.1 - 0.024 13.7 0.0 0.058 12.4 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HSP20 PF00011.16 ESA02374.1 - 1.4e-15 56.9 7.1 7.6e-10 38.5 0.2 3.1 3 0 0 3 3 3 2 Hsp20/alpha crystallin family PAT1 PF09770.4 ESA02374.1 - 0.00028 19.3 52.8 0.00034 19.0 36.6 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 GvpH PF05455.6 ESA02374.1 - 0.055 13.1 3.7 0.058 13.0 0.1 2.6 3 0 0 3 3 3 0 GvpH TFIIA PF03153.8 ESA02374.1 - 1.9 8.3 39.8 2.8 7.7 27.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Asp-B-Hydro_N PF05279.6 ESA02374.1 - 4.6 7.0 10.9 6.1 6.6 7.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3573 PF12097.3 ESA02375.1 - 0.0039 15.8 2.3 0.0039 15.8 1.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3573) Lzipper-MIP1 PF14389.1 ESA02375.1 - 0.15 12.1 14.1 0.18 11.9 2.3 3.5 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 LURAP PF14854.1 ESA02375.1 - 0.19 11.4 1.9 1.2 8.8 0.2 2.7 2 1 1 3 3 3 0 Leucine rich adaptor protein Osmo_CC PF08946.5 ESA02375.1 - 0.55 10.2 5.3 0.94 9.5 0.1 3.6 4 0 0 4 4 4 0 Osmosensory transporter coiled coil ARA70 PF12489.3 ESA02375.1 - 5 7.0 11.0 1.4 8.8 1.4 2.5 2 0 0 2 2 2 0 Nuclear coactivator NPV_P10 PF05531.7 ESA02375.1 - 7.5 6.8 9.9 0.42 10.9 1.3 2.9 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Ribosomal_S9 PF00380.14 ESA02377.1 - 6.1e-42 142.6 0.1 1.1e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 efb-c PF12199.3 ESA02377.1 - 0.18 11.6 1.2 0.99 9.3 0.0 2.7 2 0 0 2 2 2 0 Extracellular fibrinogen binding protein C terminal Ebp2 PF05890.7 ESA02378.1 - 1.8e-82 276.7 27.7 1.8e-82 276.7 19.2 1.7 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 Wzz PF02706.10 ESA02378.1 - 3.7 7.3 6.3 43 3.9 4.4 2.3 1 1 0 1 1 1 0 Chain length determinant protein Sre PF03125.13 ESA02379.1 - 0.015 14.2 1.0 0.017 14.0 0.7 1.0 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor Kelch_3 PF13415.1 ESA02380.1 - 6.4e-13 48.4 7.0 0.0003 20.8 0.0 6.0 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA02380.1 - 5.8e-12 45.2 0.2 0.035 14.0 0.1 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 ESA02380.1 - 1.2e-11 44.1 0.9 0.0039 17.2 0.1 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA02380.1 - 2e-11 43.4 2.8 8.9e-06 25.3 0.1 4.6 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA02380.1 - 3e-11 42.6 0.1 0.00017 21.2 0.0 4.0 3 0 0 3 3 3 2 Kelch motif BTB PF00651.26 ESA02380.1 - 3.2e-09 36.7 1.0 7.2e-09 35.6 0.1 2.0 2 1 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.20 ESA02380.1 - 5.1e-07 29.1 1.6 0.014 14.8 0.0 4.4 5 0 0 5 5 5 2 Kelch motif WD40 PF00400.27 ESA02381.1 - 1.6e-54 179.9 14.2 2.4e-09 36.6 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA02381.1 - 0.00026 19.2 4.0 0.1 10.7 0.6 4.3 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA02381.1 - 0.0023 16.7 0.0 0.3 9.7 0.0 2.5 1 1 1 2 2 2 2 Nup133 N terminal like KH_1 PF00013.24 ESA02382.1 - 0.0056 16.2 0.0 0.038 13.6 0.0 2.4 2 0 0 2 2 2 1 KH domain Ribonuclease_3 PF00636.21 ESA02383.1 - 5.5e-45 152.4 0.0 8e-22 77.8 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 ESA02383.1 - 1e-27 96.6 0.0 2.1e-14 53.5 0.0 3.5 2 2 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.9 ESA02383.1 - 3.2e-24 84.5 0.3 2.3e-23 81.7 0.2 2.4 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.26 ESA02383.1 - 2.5e-17 62.4 0.1 1e-16 60.5 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA02383.1 - 3.8e-15 55.7 0.0 2.3e-14 53.2 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase PAZ PF02170.17 ESA02383.1 - 1.2e-11 44.0 0.0 2.6e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 PAZ domain ResIII PF04851.10 ESA02383.1 - 9.5e-11 41.8 0.1 2.8e-10 40.3 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit dsrm PF00035.20 ESA02383.1 - 0.00021 21.8 0.2 0.085 13.4 0.1 3.0 2 0 0 2 2 2 1 Double-stranded RNA binding motif PhoH PF02562.11 ESA02383.1 - 0.12 11.6 0.0 0.32 10.1 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein ELFV_dehydrog_N PF02812.13 ESA02385.1 - 0.095 12.2 0.1 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain RCR PF12273.3 ESA02386.1 - 0.019 15.4 0.3 0.023 15.2 0.2 1.1 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red ubiquitin PF00240.18 ESA02387.1 - 0.0031 16.8 0.7 0.2 11.1 0.1 2.6 2 0 0 2 2 2 1 Ubiquitin family Chalcone PF02431.10 ESA02387.1 - 0.011 15.0 0.2 0.026 13.8 0.1 1.6 1 0 0 1 1 1 0 Chalcone-flavanone isomerase EF1G PF00647.14 ESA02387.1 - 0.044 13.4 0.3 0.11 12.2 0.2 1.7 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain zinc_ribbon_5 PF13719.1 ESA02387.1 - 0.088 12.4 6.3 0.11 12.0 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ESA02387.1 - 0.16 11.6 0.1 0.16 11.6 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_4 PF13894.1 ESA02387.1 - 0.46 10.9 10.6 0.24 11.8 2.4 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4451 PF14616.1 ESA02387.1 - 1.2 8.8 9.6 3.7 7.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4451) Zn_Tnp_IS1 PF03811.8 ESA02387.1 - 1.3 8.5 7.2 0.34 10.4 0.3 2.8 3 0 0 3 3 3 0 InsA N-terminal domain zinc-ribbons_6 PF07191.7 ESA02387.1 - 4.1 7.2 10.6 0.54 10.0 0.5 3.1 3 0 0 3 3 3 0 zinc-ribbons zf-BED PF02892.10 ESA02387.1 - 4.7 7.0 8.5 15 5.4 1.5 2.9 2 0 0 2 2 2 0 BED zinc finger zf-RING_4 PF14570.1 ESA02387.1 - 5.3 6.7 8.0 3.6 7.2 0.1 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.7 ESA02387.1 - 6.2 7.0 8.1 2.5 8.3 1.1 2.7 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_3 PF14369.1 ESA02387.1 - 8.4 6.4 8.0 1.3 9.0 0.1 3.2 4 0 0 4 4 3 0 zinc-finger Rubredoxin PF00301.15 ESA02387.1 - 8.9 6.2 9.4 15 5.5 0.1 3.8 4 0 0 4 4 4 0 Rubredoxin HypA PF01155.14 ESA02387.1 - 9.5 5.9 12.2 2.2 8.0 0.4 3.3 3 1 0 3 3 3 0 Hydrogenase expression/synthesis hypA family DUF1829 PF08862.5 ESA02388.1 - 0.045 14.0 1.7 2.4 8.5 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function DUF1829 Anoctamin PF04547.7 ESA02391.1 - 3e-111 372.2 14.9 3.7e-111 371.9 10.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel TraC_F_IV PF11130.3 ESA02391.1 - 0.025 14.0 0.2 0.066 12.6 0.0 1.7 2 0 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer TGT PF01702.13 ESA02391.1 - 0.027 13.7 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase NAD_binding_6 PF08030.7 ESA02392.1 - 2e-34 118.7 0.0 3.4e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 ESA02392.1 - 1.7e-24 85.7 0.0 4.9e-24 84.2 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.14 ESA02392.1 - 3.2e-16 59.5 6.0 3.2e-16 59.5 4.1 2.3 1 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 ESA02392.1 - 5.4e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESA02392.1 - 0.0034 17.9 0.0 0.14 12.7 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF2975 PF11188.3 ESA02392.1 - 0.63 9.7 7.0 1.3 8.6 3.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) DUF4131 PF13567.1 ESA02392.1 - 0.89 8.9 4.4 0.45 9.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) RRM_1 PF00076.17 ESA02393.1 - 1.5e-19 69.3 0.0 2.2e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02393.1 - 1e-11 44.6 0.0 1.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02393.1 - 4.8e-10 39.1 0.0 7.8e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Acyltransferase PF01553.16 ESA02395.1 - 2.3e-33 114.4 0.1 3.2e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase HMG_box PF00505.14 ESA02397.1 - 9e-22 77.1 3.2 1.3e-21 76.6 2.2 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA02397.1 - 3.1e-07 30.6 1.1 3.1e-07 30.6 0.8 1.6 2 0 0 2 2 2 1 HMG-box domain Choline_kinase PF01633.15 ESA02400.1 - 1.5e-58 197.8 0.2 2.9e-58 196.9 0.2 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA02400.1 - 1.7e-07 31.2 0.0 2.6e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ESA02400.1 - 7.3e-06 25.3 1.5 0.0016 17.6 0.5 3.0 2 1 0 2 2 2 2 Ecdysteroid kinase DUF1679 PF07914.6 ESA02400.1 - 0.013 14.1 0.0 0.018 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) CS PF04969.11 ESA02401.1 - 6e-22 77.9 1.6 1.4e-21 76.8 1.1 1.6 1 0 0 1 1 1 1 CS domain PET122 PF05476.6 ESA02401.1 - 0.017 14.3 0.1 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 PET122 DUF4404 PF14357.1 ESA02401.1 - 0.18 12.2 2.7 0.23 11.8 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) UPF0154 PF03672.8 ESA02401.1 - 0.18 11.4 3.8 6.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) ESSS PF10183.4 ESA02402.1 - 1.4e-25 89.6 0.0 1.6e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ribosomal_L6 PF00347.18 ESA02403.1 - 3.5e-34 117.1 10.4 1.6e-18 66.9 2.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF365 PF04033.7 ESA02403.1 - 0.017 15.0 0.1 0.041 13.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF365) BCDHK_Adom3 PF10436.4 ESA02403.1 - 0.037 13.5 0.5 4.3 6.8 0.1 2.1 1 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase WD40 PF00400.27 ESA02404.1 - 3.9e-16 58.2 5.0 7.2e-06 25.6 0.2 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Pkinase PF00069.20 ESA02405.1 - 1.4e-09 37.4 0.1 2.1e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02405.1 - 7.5e-07 28.4 0.0 9.8e-07 28.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ESA02405.1 - 0.046 13.7 0.0 0.099 12.6 0.0 1.7 1 1 0 1 1 1 0 ABC1 family T4_baseplate PF12322.3 ESA02405.1 - 0.06 12.5 0.1 0.069 12.4 0.1 1.1 1 0 0 1 1 1 0 T4 bacteriophage base plate protein DUF1796 PF08795.5 ESA02405.1 - 0.14 11.7 0.4 0.18 11.4 0.3 1.2 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) AntA PF08346.7 ESA02405.1 - 0.18 12.0 5.5 0.26 11.5 1.9 2.1 2 0 0 2 2 2 0 AntA/AntB antirepressor Sel1 PF08238.7 ESA02406.1 - 1.8e-72 238.1 25.8 8.6e-11 42.1 0.2 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA02406.1 - 1.3e-09 37.8 6.5 0.45 11.0 0.1 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TRI5 PF06330.6 ESA02406.1 - 0.12 10.9 3.8 0.31 9.6 0.1 2.8 2 1 2 4 4 4 0 Trichodiene synthase (TRI5) SmpB PF01668.13 ESA02406.1 - 0.16 11.7 2.5 3.1 7.6 0.1 2.6 2 0 0 2 2 2 0 SmpB protein Pkinase_Tyr PF07714.12 ESA02408.1 - 2.4e-40 138.2 0.0 2.6e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02408.1 - 4.6e-37 127.5 0.1 5.2e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA02408.1 - 0.0079 15.9 0.3 0.011 15.4 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family E_Pc_C PF06752.7 ESA02409.1 - 0.028 13.9 2.1 0.028 13.9 0.2 1.8 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus RNase_H PF00075.19 ESA02409.1 - 0.13 12.5 0.0 0.78 10.0 0.0 2.0 1 1 0 2 2 2 0 RNase H UQ_con PF00179.21 ESA02410.1 - 1.4e-36 125.0 0.0 1.5e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA02410.1 - 0.014 15.2 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain ROS_MUCR PF05443.6 ESA02413.1 - 0.056 13.2 0.3 0.061 13.0 0.2 1.0 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein Pkinase_Tyr PF07714.12 ESA02414.1 - 7e-44 149.8 0.2 4.9e-35 120.8 0.0 5.0 6 0 0 6 6 6 3 Protein tyrosine kinase Pkinase PF00069.20 ESA02414.1 - 9e-41 139.7 8.5 3.8e-37 127.8 0.0 3.9 4 0 0 4 4 4 2 Protein kinase domain BCS1_N PF08740.6 ESA02414.1 - 9.1e-11 41.7 0.3 0.1 12.1 0.0 5.4 5 0 0 5 5 5 4 BCS1 N terminal DUF4413 PF14372.1 ESA02414.1 - 9e-05 22.4 15.2 2 8.4 0.1 6.1 5 0 0 5 5 5 3 Domain of unknown function (DUF4413) PORR PF11955.3 ESA02416.1 - 0.01 14.5 0.1 0.012 14.3 0.1 1.0 1 0 0 1 1 1 0 Plant organelle RNA recognition domain PI-PLC-X PF00388.14 ESA02416.1 - 0.057 12.8 0.1 0.068 12.5 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Acyl_transf_3 PF01757.17 ESA02417.1 - 0.037 12.8 4.5 0.062 12.1 3.1 1.3 1 0 0 1 1 1 0 Acyltransferase family DUF4131 PF13567.1 ESA02417.1 - 0.27 10.6 4.6 0.45 9.9 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF4181 PF13789.1 ESA02417.1 - 1.2 9.0 4.7 0.63 9.9 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) DUF4356 PF14266.1 ESA02418.1 - 0.012 14.0 0.8 0.015 13.7 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4356) DUF2347 PF09804.4 ESA02418.1 - 0.054 12.7 2.6 0.062 12.5 1.8 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF3713 PF12506.3 ESA02418.1 - 0.45 10.5 5.5 1.8 8.6 3.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3713) DUF2012 PF09430.5 ESA02421.1 - 3.4e-25 88.2 0.0 5.3e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.1 ESA02421.1 - 0.00012 22.0 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 ESA02421.1 - 0.0039 17.2 0.1 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4480) DUF2404 PF10296.4 ESA02422.1 - 1.2e-27 95.9 0.0 3.3e-27 94.4 0.0 1.8 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) PH PF00169.24 ESA02422.1 - 1.2e-05 25.4 0.4 2.9e-05 24.1 0.3 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESA02422.1 - 0.0045 17.2 0.6 0.019 15.2 0.1 2.2 2 1 0 2 2 2 1 Pleckstrin homology domain Kelch_4 PF13418.1 ESA02424.1 - 4.5e-14 51.9 7.0 6.4e-05 22.6 0.0 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA02424.1 - 1.3e-10 40.9 10.8 0.0054 16.8 0.1 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 ESA02424.1 - 3.2e-10 39.7 14.7 2.1e-05 24.3 0.2 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA02424.1 - 1.5e-08 34.0 5.9 0.00069 19.2 0.0 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA02424.1 - 9.9e-08 31.9 15.2 0.063 13.4 0.1 5.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA02424.1 - 3e-07 29.8 9.9 0.074 12.6 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Glyco_transf_15 PF01793.11 ESA02425.1 - 0.038 12.9 0.1 0.047 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Sigma_reg_C PF13791.1 ESA02425.1 - 0.039 14.0 0.3 0.041 13.9 0.2 1.1 1 0 0 1 1 1 0 Sigma factor regulator C-terminal GH97_C PF14509.1 ESA02428.1 - 0.053 13.6 0.2 0.067 13.3 0.1 1.0 1 0 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation STE PF02200.11 ESA02429.1 - 1.2e-60 202.4 0.1 2.1e-60 201.6 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.21 ESA02429.1 - 1.4e-12 47.1 11.7 1.9e-06 27.8 1.0 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA02429.1 - 3.4e-09 36.3 12.5 0.00015 21.8 0.5 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA02429.1 - 1.7e-07 31.1 2.8 1.7e-07 31.1 1.9 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.1 ESA02429.1 - 0.00012 21.8 2.6 0.00022 21.0 0.4 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA02429.1 - 0.00032 20.7 1.3 0.013 15.5 0.2 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA02429.1 - 0.064 13.4 4.4 0.47 10.7 0.4 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type IDEAL PF08858.5 ESA02430.1 - 0.025 14.0 0.0 0.089 12.2 0.0 2.0 1 1 0 1 1 1 0 IDEAL domain phiKZ_IP PF12699.2 ESA02436.1 - 0.018 13.9 0.0 0.021 13.7 0.0 1.0 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins RSV_NS2 PF03113.9 ESA02439.1 - 0.13 12.1 3.7 0.31 11.0 0.0 2.8 3 0 0 3 3 3 0 Respiratory synctial virus non-structural protein NS2 DPCD PF14913.1 ESA02440.1 - 0.044 12.9 0.1 0.085 11.9 0.1 1.4 1 0 0 1 1 1 0 DPCD protein family Sel1 PF08238.7 ESA02443.1 - 6.7e-56 185.5 20.4 2e-13 50.5 0.8 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_7 PF13176.1 ESA02443.1 - 2.8e-05 23.5 0.6 0.7 9.8 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 ESA02443.1 - 0.0017 18.0 8.4 0.3 10.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA02443.1 - 0.01 15.8 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain TPR_11 PF13414.1 ESA02443.1 - 0.019 14.5 19.6 0.16 11.6 2.2 4.0 2 2 1 3 3 3 0 TPR repeat TPR_12 PF13424.1 ESA02443.1 - 0.02 14.8 13.7 0.3 11.0 0.6 4.7 3 3 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA02443.1 - 0.031 14.1 11.8 2.3 8.1 0.1 5.0 3 1 2 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 ESA02443.1 - 0.32 11.0 21.1 4.8 7.3 0.1 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA02443.1 - 6.1 6.9 7.1 6.7 6.7 1.1 3.4 2 2 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA02444.1 - 9.2e-46 156.0 0.0 1.1e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02444.1 - 9.3e-41 139.5 0.0 1e-40 139.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA02444.1 - 0.0087 15.2 0.1 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA02444.1 - 0.0096 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA02444.1 - 0.018 14.1 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA02444.1 - 0.037 13.7 0.1 0.56 9.8 0.2 2.4 1 1 2 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA02444.1 - 0.042 13.2 2.1 0.16 11.3 1.5 1.9 1 1 0 1 1 1 0 RIO1 family ABC1 PF03109.11 ESA02444.1 - 0.11 12.4 0.0 0.43 10.5 0.0 2.0 1 1 0 1 1 1 0 ABC1 family DUF3991 PF13154.1 ESA02445.1 - 0.015 15.4 0.6 0.095 12.9 0.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3991) DUF4274 PF14096.1 ESA02445.1 - 0.041 13.6 0.1 0.51 10.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4274) zf-DHHC PF01529.15 ESA02447.1 - 0.14 11.5 2.1 0.15 11.4 1.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase FAR1 PF03101.10 ESA02448.1 - 0.03 14.8 0.0 0.052 14.0 0.0 1.4 1 0 0 1 1 1 0 FAR1 DNA-binding domain P4Ha_N PF08336.6 ESA02449.1 - 0.048 13.4 0.1 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Baculo_PEP_C PF04513.7 ESA02449.1 - 0.058 13.2 0.0 0.073 12.8 0.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 ESA02449.1 - 0.067 12.7 0.1 0.075 12.5 0.1 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HSDR_N_2 PF13588.1 ESA02449.1 - 0.077 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Seryl_tRNA_N PF02403.17 ESA02449.1 - 0.079 12.9 0.3 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DASH_Duo1 PF08651.5 ESA02449.1 - 0.11 12.0 0.2 0.9 9.1 0.1 2.0 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF2183 PF09949.4 ESA02450.1 - 0.046 13.6 0.1 0.048 13.5 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) CagE_TrbE_VirB PF03135.9 ESA02450.1 - 0.052 13.3 0.3 0.052 13.3 0.2 1.0 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Bacillus_HBL PF05791.6 ESA02450.1 - 0.063 12.6 0.2 0.07 12.4 0.1 1.0 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) PPP5 PF08321.7 ESA02450.1 - 0.089 12.8 0.1 0.092 12.7 0.1 1.1 1 0 0 1 1 1 0 PPP5 TPR repeat region FAR1 PF03101.10 ESA02451.1 - 3.2e-10 40.3 0.3 4.8e-10 39.8 0.2 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain DUF3871 PF12987.2 ESA02454.1 - 0.077 11.6 0.0 0.078 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3871) HCV_NS5a_C PF12941.2 ESA02457.1 - 0.0011 18.5 1.1 0.035 13.6 0.3 2.1 2 0 0 2 2 2 2 HCV NS5a protein C-terminal region HNF-1_N PF04814.8 ESA02457.1 - 4.1 7.4 6.2 0.97 9.5 1.3 1.9 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Herpes_UL25 PF01499.11 ESA02458.1 - 0.0011 17.4 4.1 0.0015 16.9 2.8 1.3 1 0 0 1 1 1 1 Herpesvirus UL25 family DivIC PF04977.10 ESA02458.1 - 0.6 9.6 16.2 1.3 8.5 3.0 4.0 1 1 1 2 2 2 0 Septum formation initiator TSC22 PF01166.13 ESA02458.1 - 7.2 6.6 22.0 0.8 9.7 4.8 4.8 3 2 0 3 3 3 0 TSC-22/dip/bun family MtN3_slv PF03083.11 ESA02460.1 - 0.46 10.3 4.3 0.13 12.1 0.8 1.7 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Pkinase_Tyr PF07714.12 ESA02463.1 - 1.9e-31 109.0 0.0 2.3e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02463.1 - 1.1e-28 100.0 1.9 2.1e-28 99.1 1.3 1.4 1 1 0 1 1 1 1 Protein kinase domain Pox_J1 PF03338.10 ESA02463.1 - 0.062 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Poxvirus J1 protein RasGAP PF00616.14 ESA02464.1 - 1.1e-38 132.9 2.6 1.5e-38 132.4 0.3 2.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.1 ESA02464.1 - 4.2e-22 78.6 1.5 3.9e-21 75.4 0.0 3.4 4 0 0 4 4 4 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 ESA02464.1 - 3.5e-05 23.3 0.1 0.00028 20.4 0.0 2.6 2 0 0 2 2 2 1 CRAL/TRIO domain HEAT PF02985.17 ESA02464.1 - 0.0071 16.3 0.5 4.4 7.6 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat DUF4413 PF14372.1 ESA02465.1 - 0.0063 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Dimer_Tnp_hAT PF05699.9 ESA02466.1 - 7.2e-14 51.1 0.0 8.6e-14 50.9 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region BTB PF00651.26 ESA02467.1 - 1e-22 80.2 1.4 1.4e-19 70.1 0.1 2.9 3 0 0 3 3 3 2 BTB/POZ domain SPRY PF00622.23 ESA02467.1 - 2e-12 47.2 1.0 3.8e-12 46.3 0.7 1.4 1 0 0 1 1 1 1 SPRY domain HTH_Tnp_Mu_2 PF09039.6 ESA02467.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.6 1 1 0 1 1 1 0 Mu DNA binding, I gamma subdomain BTB PF00651.26 ESA02468.1 - 6.8e-20 71.1 0.3 5.3e-19 68.2 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA02469.1 - 7.8e-10 38.9 0.0 8.6e-10 38.7 0.0 1.0 1 0 0 1 1 1 1 SPRY domain ECR1_N PF14382.1 ESA02469.1 - 0.15 11.4 0.1 0.59 9.4 0.0 2.0 3 0 0 3 3 3 0 Exosome complex exonuclease RRP4 N-terminal region ABC_tran PF00005.22 ESA02470.1 - 1.9e-53 180.4 0.6 3.4e-31 108.3 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 ESA02470.1 - 1.5e-52 178.7 45.5 2.5e-33 115.6 7.7 4.5 4 1 0 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.14 ESA02470.1 - 3.3e-09 36.2 6.0 0.0032 16.7 0.6 4.4 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain T2SE PF00437.15 ESA02470.1 - 1.2e-05 24.3 0.0 0.024 13.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.1 ESA02470.1 - 2.7e-05 23.6 0.0 0.16 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESA02470.1 - 0.00015 21.8 0.2 0.086 12.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 ESA02470.1 - 0.00035 20.0 0.5 0.13 11.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 ESA02470.1 - 0.00039 19.9 0.1 0.55 9.6 0.0 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_17 PF13207.1 ESA02470.1 - 0.0004 21.1 0.3 0.35 11.7 0.0 3.5 3 0 0 3 3 2 1 AAA domain AAA_10 PF12846.2 ESA02470.1 - 0.00064 19.2 0.2 0.5 9.7 0.0 2.7 2 0 0 2 2 2 2 AAA-like domain AAA_23 PF13476.1 ESA02470.1 - 0.00073 19.9 10.5 0.016 15.5 0.1 3.8 4 1 0 4 4 4 2 AAA domain AAA_16 PF13191.1 ESA02470.1 - 0.0075 16.2 0.1 3.3 7.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 ESA02470.1 - 0.0091 15.1 0.1 1.8 7.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ResIII PF04851.10 ESA02470.1 - 0.014 15.2 0.5 9.4 6.0 0.0 3.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_18 PF13238.1 ESA02470.1 - 0.015 15.6 5.2 1.6 9.0 0.0 3.9 4 0 0 4 4 2 0 AAA domain DUF87 PF01935.12 ESA02470.1 - 0.02 14.7 2.1 0.22 11.3 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF87 MobB PF03205.9 ESA02470.1 - 0.027 14.1 0.6 5.1 6.8 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.24 ESA02470.1 - 0.028 13.9 0.0 5.5 6.4 0.0 2.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase MMR_HSR1 PF01926.18 ESA02470.1 - 0.033 14.1 0.4 1.2 9.1 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase Miro PF08477.8 ESA02470.1 - 0.035 14.5 2.1 9.8 6.7 0.0 3.3 3 0 0 3 3 3 0 Miro-like protein Mg_chelatase PF01078.16 ESA02470.1 - 0.044 12.9 0.0 1.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.20 ESA02470.1 - 0.056 12.9 0.3 3 7.2 0.0 2.5 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.1 ESA02470.1 - 0.08 12.8 2.0 2 8.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.9 ESA02470.1 - 0.085 12.5 0.2 15 5.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESA02470.1 - 0.097 12.3 1.0 2.3 7.8 0.1 2.5 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.12 ESA02470.1 - 0.11 11.8 1.1 6.3 6.1 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF2457 PF10446.4 ESA02470.1 - 2.4 6.7 12.5 4.4 5.9 8.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRM_1 PF00076.17 ESA02471.1 - 3.2e-10 39.4 0.0 0.0012 18.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02471.1 - 3.4e-06 26.9 0.0 0.03 14.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02471.1 - 0.00079 19.2 0.2 0.62 9.9 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAM2 PF07145.10 ESA02471.1 - 0.021 14.3 1.3 0.021 14.3 0.9 2.3 2 0 0 2 2 2 0 Ataxin-2 C-terminal region DUF3421 PF11901.3 ESA02472.1 - 2.8e-17 62.5 6.5 4.9e-14 52.0 0.7 2.8 1 1 2 3 3 3 2 Protein of unknown function (DUF3421) MtrF PF09472.5 ESA02473.1 - 0.14 11.3 0.4 0.25 10.6 0.3 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) zf-CCHC PF00098.18 ESA02474.1 - 0.031 14.1 6.2 0.031 14.1 4.3 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CpG_bind_C PF12269.3 ESA02475.1 - 0.072 12.5 0.3 0.086 12.2 0.2 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain UCH_1 PF13423.1 ESA02476.1 - 7.6e-63 212.6 2.8 1.3e-62 211.9 1.9 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 ESA02476.1 - 4.8e-26 92.0 0.0 9.4e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.24 ESA02476.1 - 2.2e-17 63.0 4.4 1.3e-16 60.5 3.1 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3139 PF11337.3 ESA02476.1 - 0.01 16.0 0.6 0.027 14.7 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) BRO1 PF03097.13 ESA02478.1 - 2e-18 66.2 0.1 2.5e-18 66.0 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain BAR_3_WASP_bdg PF10456.4 ESA02478.1 - 0.086 12.0 0.8 0.18 11.0 0.5 1.4 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein 3-HAO PF06052.7 ESA02479.1 - 6.2e-68 226.9 0.1 6.9e-68 226.7 0.1 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 ESA02479.1 - 3.4e-07 29.6 0.0 6.5e-07 28.7 0.0 1.4 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 ESA02479.1 - 5.3e-05 22.6 0.0 6.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.14 ESA02479.1 - 0.0033 17.1 0.0 0.005 16.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF1732 PF08340.6 ESA02479.1 - 0.033 14.0 0.0 0.084 12.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) DZR PF12773.2 ESA02479.1 - 0.046 13.5 1.5 0.074 12.8 1.0 1.3 1 0 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.1 ESA02479.1 - 0.24 11.1 3.7 0.24 11.1 0.4 2.2 2 0 0 2 2 2 0 Nudix N-terminal RecR PF02132.10 ESA02479.1 - 0.26 10.7 0.1 0.26 10.7 0.0 2.0 2 0 0 2 2 2 0 RecR protein Desulfoferrod_N PF06397.7 ESA02479.1 - 0.51 9.7 0.1 0.51 9.7 0.1 2.6 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf-RanBP PF00641.13 ESA02479.1 - 5.4 6.2 5.7 13 4.9 0.4 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Uma2 PF05685.7 ESA02482.1 - 0.0023 17.2 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 Putative restriction endonuclease Pkinase PF00069.20 ESA02483.1 - 2e-22 79.6 0.3 2.1e-22 79.5 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02483.1 - 7.6e-18 64.5 0.1 8.7e-18 64.3 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA02483.1 - 0.0044 16.0 0.0 0.0044 16.0 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA02483.1 - 0.0086 15.1 0.0 0.0092 15.0 0.0 1.0 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA02483.1 - 0.01 15.1 0.0 0.012 14.9 0.0 1.0 1 0 0 1 1 1 0 RIO1 family Pox_A8 PF04745.7 ESA02483.1 - 0.019 13.8 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 VITF-3 subunit protein APH PF01636.18 ESA02483.1 - 0.036 13.8 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family DNA_pol_B PF00136.16 ESA02484.1 - 4.4e-30 104.8 3.8 1.3e-26 93.4 0.1 2.1 2 0 0 2 2 2 2 DNA polymerase family B YchF-GTPase_C PF06071.8 ESA02484.1 - 0.13 12.0 0.6 0.31 10.8 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF933) zf-CCHC_2 PF13696.1 ESA02485.1 - 0.1 12.1 0.4 0.22 11.0 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 ESA02485.1 - 0.46 10.5 2.9 0.75 9.8 2.0 1.3 1 0 0 1 1 1 0 Zinc knuckle DUF4134 PF13572.1 ESA02486.1 - 0.00029 20.8 1.5 24 5.1 0.0 5.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4134) DUF2190 PF09956.4 ESA02486.1 - 0.00067 19.3 2.4 2.6 7.8 0.0 4.3 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2190) GPS PF01825.16 ESA02486.1 - 0.0021 18.1 20.0 0.051 13.7 0.1 4.5 5 0 0 5 5 5 3 Latrophilin/CL-1-like GPS domain GP46 PF07409.7 ESA02486.1 - 0.11 11.8 3.8 9.6 5.5 0.0 3.7 4 0 0 4 4 4 0 Phage protein GP46 DUF2789 PF10982.3 ESA02486.1 - 0.26 11.3 10.2 6 6.9 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF2789) Fn3-like PF14310.1 ESA02486.1 - 3.9 7.4 5.1 30 4.6 0.1 3.3 3 0 0 3 3 3 0 Fibronectin type III-like domain ACDC PF14733.1 ESA02486.1 - 7.3 6.7 13.5 57 3.9 0.1 5.2 5 0 0 5 5 5 0 AP2-coincident C-terminal DUF4355 PF14265.1 ESA02488.1 - 0.088 12.7 0.3 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Gal4_dimer PF03902.8 ESA02488.1 - 0.12 12.2 0.3 0.19 11.6 0.2 1.3 1 0 0 1 1 1 0 Gal4-like dimerisation domain Atg14 PF10186.4 ESA02489.1 - 0.00016 20.7 8.8 0.00017 20.6 6.1 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Laminin_I PF06008.9 ESA02489.1 - 0.00041 19.7 2.5 0.00045 19.6 1.7 1.1 1 0 0 1 1 1 1 Laminin Domain I CALCOCO1 PF07888.6 ESA02489.1 - 0.0032 15.8 6.0 0.0035 15.6 4.2 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.3 ESA02489.1 - 0.02 14.8 5.7 0.03 14.2 3.7 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding FliD_C PF07195.7 ESA02489.1 - 0.029 13.6 0.9 0.044 13.0 0.6 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus APG17 PF04108.7 ESA02489.1 - 0.044 12.5 2.5 0.051 12.3 1.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Spc7 PF08317.6 ESA02489.1 - 0.047 12.3 9.1 0.054 12.1 6.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.7 ESA02489.1 - 0.058 13.1 5.2 0.085 12.6 3.6 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 ESA02489.1 - 0.059 13.0 9.7 0.096 12.3 6.7 1.4 1 1 0 1 1 1 0 Mnd1 family YgbB PF02542.11 ESA02489.1 - 0.065 13.0 1.5 0.1 12.4 0.2 1.8 1 1 1 2 2 2 0 YgbB family HAUS5 PF14817.1 ESA02489.1 - 0.13 10.7 5.0 0.16 10.5 3.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 PID PF00640.18 ESA02489.1 - 0.15 12.0 1.1 0.21 11.5 0.8 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Cytochrom_B562 PF07361.6 ESA02489.1 - 0.17 12.2 5.1 3.2 8.2 3.5 2.2 1 1 0 1 1 1 0 Cytochrome b562 IFT57 PF10498.4 ESA02489.1 - 0.2 10.3 7.9 0.24 10.0 5.5 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DivIC PF04977.10 ESA02489.1 - 0.2 11.1 11.1 0.39 10.2 5.0 2.8 1 1 1 2 2 2 0 Septum formation initiator IncA PF04156.9 ESA02489.1 - 0.29 10.7 8.0 0.54 9.8 5.5 1.4 1 1 0 1 1 1 0 IncA protein GLE1 PF07817.8 ESA02489.1 - 0.3 9.9 1.9 0.39 9.6 1.3 1.3 1 0 0 1 1 1 0 GLE1-like protein Spc24 PF08286.6 ESA02489.1 - 0.94 9.1 8.7 56 3.4 6.0 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF2228 PF10228.4 ESA02489.1 - 1.1 8.7 5.1 1.2 8.6 3.5 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) DUF1664 PF07889.7 ESA02489.1 - 1.1 9.0 9.1 0.75 9.6 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.3 ESA02489.1 - 1.1 8.2 5.8 1.3 7.9 4.0 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein APG6 PF04111.7 ESA02489.1 - 1.3 8.0 6.7 1.5 7.7 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 FlxA PF14282.1 ESA02489.1 - 1.8 8.5 9.0 2.6 8.0 6.0 1.6 1 1 0 1 1 1 0 FlxA-like protein Prefoldin_2 PF01920.15 ESA02489.1 - 2.5 7.8 12.7 0.2 11.4 3.1 2.6 2 1 1 3 3 3 0 Prefoldin subunit Tup_N PF08581.5 ESA02489.1 - 3.9 7.7 12.5 0.69 10.1 0.6 2.7 1 1 1 2 2 2 0 Tup N-terminal Bap31 PF05529.7 ESA02489.1 - 4.6 6.6 7.1 5.9 6.3 4.7 1.4 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like COG2 PF06148.6 ESA02489.1 - 5.5 6.8 7.5 1.3 8.9 1.1 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4200 PF13863.1 ESA02489.1 - 5.8 6.8 16.8 14 5.6 9.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DP PF08781.5 ESA02489.1 - 7.7 6.1 9.2 0.3 10.7 1.3 2.0 1 1 1 2 2 2 0 Transcription factor DP PQQ PF01011.16 ESA02490.1 - 1.1e-09 37.3 0.8 0.0039 16.6 0.0 3.5 4 0 0 4 4 4 3 PQQ enzyme repeat PQQ_2 PF13360.1 ESA02490.1 - 1.9e-08 34.0 0.0 8e-08 32.0 0.0 1.6 1 1 0 1 1 1 1 PQQ-like domain Vps16_N PF04841.8 ESA02490.1 - 0.067 11.7 0.1 0.083 11.3 0.1 1.1 1 0 0 1 1 1 0 Vps16, N-terminal region Pkinase_Tyr PF07714.12 ESA02491.1 - 8.2e-35 120.1 0.1 5.2e-23 81.4 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA02491.1 - 6.4e-26 91.0 0.1 3.1e-22 78.9 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain BTB PF00651.26 ESA02492.1 - 5e-13 48.9 0.2 1.6e-12 47.4 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA02492.1 - 6.9e-13 48.7 1.1 6.9e-13 48.7 0.8 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02492.1 - 1.2e-07 31.5 2.9 2.9e-06 27.0 0.1 3.7 2 1 2 4 4 4 1 BTB And C-terminal Kelch DUF3942 PF13078.1 ESA02492.1 - 0.22 11.6 6.5 0.32 11.1 2.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3942) TusA PF01206.12 ESA02495.1 - 0.086 12.4 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Sulfurtransferase TusA Nucleos_tra2_C PF07662.8 ESA02497.1 - 0.062 12.7 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter C-terminus DUF1884 PF08967.5 ESA02497.1 - 0.13 12.3 0.1 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) Nop PF01798.13 ESA02498.1 - 1.3e-60 203.0 0.0 3.7e-60 201.5 0.0 1.9 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 ESA02498.1 - 6e-28 96.4 0.6 1.5e-27 95.1 0.4 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 ESA02498.1 - 5.3e-22 77.7 0.7 5.3e-22 77.7 0.5 3.3 3 1 1 4 4 4 1 NOP5NT (NUC127) domain Sel1 PF08238.7 ESA02500.1 - 7.3e-07 29.6 0.1 0.047 14.3 0.2 4.1 4 1 0 4 4 4 2 Sel1 repeat TPR_11 PF13414.1 ESA02500.1 - 0.0063 16.1 4.2 0.21 11.2 0.4 2.7 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.1 ESA02500.1 - 0.22 11.8 1.4 55 4.3 0.1 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat GalKase_gal_bdg PF10509.4 ESA02501.1 - 1.5e-21 75.4 0.0 3.3e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 ESA02501.1 - 3.1e-13 49.7 0.0 7.4e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 ESA02501.1 - 2.2e-12 46.8 0.2 7.3e-12 45.1 0.1 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain PhoU PF01895.14 ESA02501.1 - 0.12 12.8 0.7 0.36 11.3 0.1 2.2 2 0 0 2 2 2 0 PhoU domain ubiquitin PF00240.18 ESA02502.1 - 2e-13 49.5 0.2 3.7e-13 48.6 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA02502.1 - 5.7e-07 29.1 0.6 1.2e-06 28.1 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF3990 PF13151.1 ESA02502.1 - 0.0095 15.3 0.3 0.023 14.0 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) PARP PF00644.15 ESA02502.1 - 0.057 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain BTB PF00651.26 ESA02503.1 - 4.9e-28 97.3 1.9 1.3e-13 50.8 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain TLD PF07534.11 ESA02503.1 - 1.5e-09 37.9 1.2 1.5e-09 37.9 0.8 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02503.1 - 1.1e-06 28.3 5.2 2.1e-06 27.5 0.9 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF2036 PF09724.4 ESA02503.1 - 0.0026 16.9 0.6 1 8.4 0.0 2.2 1 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2036) Fer4_2 PF12797.2 ESA02504.1 - 1.5 8.9 4.1 9.2 6.4 1.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Sel1 PF08238.7 ESA02505.1 - 2.7e-100 326.6 16.5 2.5e-11 43.8 0.5 12.0 12 0 0 12 12 12 11 Sel1 repeat AnfG_VnfG PF03139.10 ESA02505.1 - 0.003 17.3 0.2 6.9 6.4 0.0 3.4 3 0 0 3 3 3 1 Vanadium/alternative nitrogenase delta subunit MKT1_C PF12246.3 ESA02505.1 - 0.0035 16.3 0.1 1.2 8.0 0.0 2.5 2 0 0 2 2 2 2 Temperature dependent protein affecting M2 dsRNA replication Flu_M1_C PF08289.6 ESA02505.1 - 0.0039 17.1 0.1 18 5.4 0.0 4.6 3 1 3 6 6 6 1 Influenza Matrix protein (M1) C-terminal domain RNase_H PF00075.19 ESA02508.1 - 5.9e-06 26.6 0.0 1.4e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 RNase H F-box-like PF12937.2 ESA02509.1 - 0.023 14.4 3.4 0.062 13.0 2.3 1.7 1 0 0 1 1 1 0 F-box-like CDC45 PF02724.9 ESA02509.1 - 1.7 6.6 13.2 1.4 6.8 8.0 1.6 2 0 0 2 2 2 0 CDC45-like protein ORC6 PF05460.8 ESA02511.1 - 1.5 7.8 5.7 2.1 7.3 4.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4250 PF14056.1 ESA02512.1 - 0.11 12.2 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) UDPGT PF00201.13 ESA02514.1 - 4.9e-08 31.9 0.1 7.1e-08 31.4 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA02514.1 - 0.044 13.4 5.0 0.072 12.7 1.4 2.5 2 1 1 3 3 3 0 Glycosyltransferase family 28 C-terminal domain Mit_KHE1 PF10173.4 ESA02514.1 - 2.4 7.9 6.9 3.7 7.3 0.5 2.3 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Peptidase_C97 PF05903.9 ESA02516.1 - 0.0075 16.0 0.2 0.0091 15.7 0.1 1.4 1 1 0 1 1 1 1 PPPDE putative peptidase domain Lipocalin_4 PF13648.1 ESA02516.1 - 0.04 14.5 1.5 0.064 13.8 1.0 1.3 1 0 0 1 1 1 0 Lipocalin-like domain MFS_1 PF07690.11 ESA02517.1 - 2.4e-43 148.2 25.6 3.7e-43 147.6 17.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_6 PF10746.4 ESA02517.1 - 0.083 12.6 0.0 0.34 10.6 0.0 2.1 1 0 0 1 1 1 0 Phage holin family 6 Peptidase_C97 PF05903.9 ESA02518.1 - 0.025 14.3 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 PPPDE putative peptidase domain Phage_mat-A PF03863.8 ESA02520.1 - 0.019 14.0 0.1 0.024 13.7 0.1 1.1 1 0 0 1 1 1 0 Phage maturation protein DUF3213 PF11491.3 ESA02520.1 - 0.026 14.4 0.5 0.074 12.9 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) HTH_Tnp_IS1 PF12759.2 ESA02521.1 - 0.011 15.0 0.1 0.023 14.1 0.1 1.4 1 0 0 1 1 1 0 InsA C-terminal domain Helicase_C PF00271.26 ESA02522.1 - 1.2e-05 25.0 0.0 2.9e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Endonuc-MspI PF09208.5 ESA02522.1 - 0.0024 17.0 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease MspI DUF4551 PF15087.1 ESA02522.1 - 0.028 12.7 0.1 0.047 12.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1542 PF07564.6 ESA02523.1 - 0.0062 16.5 4.8 0.015 15.3 1.4 2.1 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA02523.1 - 0.032 14.0 2.3 0.052 13.3 0.4 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF148 Peptidase_C97 PF05903.9 ESA02523.1 - 0.098 12.4 0.1 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 PPPDE putative peptidase domain Helicase_C PF00271.26 ESA02524.1 - 0.0026 17.5 0.0 0.0062 16.3 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Citrate_ly_lig PF08218.6 ESA02524.1 - 0.02 14.3 0.8 0.045 13.2 0.6 1.6 1 1 0 1 1 1 0 Citrate lyase ligase C-terminal domain Endonuc-MspI PF09208.5 ESA02524.1 - 0.036 13.1 1.8 0.04 12.9 1.1 1.2 1 1 0 1 1 1 0 Restriction endonuclease MspI zf-FCS PF06467.9 ESA02525.1 - 6.6e-07 28.8 8.4 0.0032 17.0 1.1 2.4 2 0 0 2 2 2 2 MYM-type Zinc finger with FCS sequence motif DUF329 PF03884.9 ESA02525.1 - 0.00018 20.9 5.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF329) zf-CGNR PF11706.3 ESA02525.1 - 0.016 14.7 0.4 0.016 14.7 0.3 2.3 2 1 0 2 2 2 0 CGNR zinc finger Metallothio_Pro PF02069.11 ESA02525.1 - 9.5 6.1 10.0 27 4.6 1.7 2.6 1 1 1 2 2 2 0 Prokaryotic metallothionein PARP PF00644.15 ESA02526.1 - 0.083 12.3 0.1 11 5.3 0.0 2.1 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain TLD PF07534.11 ESA02527.1 - 1.6e-21 76.7 0.7 5e-21 75.1 0.5 1.8 1 1 0 1 1 1 1 TLD DUF4297 PF14130.1 ESA02527.1 - 3.2 7.6 9.0 2.4 8.0 1.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4297) Abhydrolase_6 PF12697.2 ESA02528.1 - 1.7e-14 54.2 0.0 2.2e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA02528.1 - 7.9e-10 38.6 0.0 2.5e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Cutinase PF01083.17 ESA02528.1 - 0.038 13.7 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 Cutinase Pyr_redox_2 PF07992.9 ESA02530.1 - 2.9e-28 99.1 0.0 1e-27 97.3 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.17 ESA02530.1 - 5.9e-25 87.4 0.2 1.2e-24 86.5 0.1 1.5 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rieske_2 PF13806.1 ESA02530.1 - 1.3e-23 82.6 0.0 3.5e-23 81.3 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Fer2_BFD PF04324.10 ESA02530.1 - 1.3e-18 66.7 6.7 1.1e-13 50.9 4.0 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Pyr_redox PF00070.22 ESA02530.1 - 2e-18 66.5 1.0 1.6e-17 63.6 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 ESA02530.1 - 1.1e-14 53.7 0.2 2.8e-14 52.4 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.12 ESA02530.1 - 7.4e-13 47.9 0.0 1.8e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain DAO PF01266.19 ESA02530.1 - 2.5e-07 29.9 0.4 0.0039 16.1 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESA02530.1 - 5.8e-07 29.7 0.0 5.4e-06 26.6 0.0 2.4 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 ESA02530.1 - 4.9e-05 23.5 0.1 0.41 10.9 0.0 2.7 2 0 0 2 2 2 2 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 ESA02530.1 - 0.00059 19.4 0.0 0.0025 17.4 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.1 ESA02530.1 - 0.0031 17.3 0.9 16 5.2 0.0 3.5 2 1 1 3 3 3 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA02530.1 - 0.0099 15.8 0.3 0.04 13.9 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESA02530.1 - 0.012 14.5 0.3 0.11 11.3 0.2 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.19 ESA02530.1 - 0.019 13.8 4.1 0.24 10.2 0.4 2.6 2 1 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.13 ESA02530.1 - 0.03 13.9 0.1 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.9 ESA02530.1 - 0.05 12.0 0.7 11 4.3 0.7 3.0 2 1 1 3 3 3 0 HI0933-like protein FAD_binding_3 PF01494.14 ESA02530.1 - 0.68 8.9 1.7 1.1 8.2 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain RTC4 PF14474.1 ESA02531.1 - 0.12 12.2 0.0 0.14 12.1 0.0 1.3 1 1 0 1 1 1 0 RTC4-like domain RRM_1 PF00076.17 ESA02532.1 - 2.1e-11 43.2 0.1 1.4e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02532.1 - 3.3e-10 39.6 0.1 5.1e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02532.1 - 2.1e-08 34.0 0.0 8.8e-08 32.0 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GTP_CH_N PF12471.3 ESA02533.1 - 4.9e-89 297.1 0.0 1.1e-88 296.0 0.0 1.5 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 ESA02533.1 - 8.3e-19 67.4 0.0 2e-18 66.2 0.0 1.6 2 0 0 2 2 2 1 GTP cyclohydrolase II Matrilin_ccoil PF10393.4 ESA02533.1 - 0.04 13.2 0.9 0.097 12.0 0.6 1.6 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Apolipoprotein PF01442.13 ESA02533.1 - 0.045 13.2 0.9 0.073 12.5 0.6 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain UPRTase PF14681.1 ESA02534.1 - 8.7e-71 237.4 0.0 9.9e-71 237.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 ESA02534.1 - 2.8e-07 30.3 0.0 6.8e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRP19 PF01922.12 ESA02535.1 - 4.5e-27 94.4 0.0 6.9e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein AAA PF00004.24 ESA02536.1 - 3.6e-42 143.6 0.0 6.3e-42 142.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA02536.1 - 2e-06 27.9 0.1 0.00037 20.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESA02536.1 - 3.6e-06 26.9 0.0 7.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 ESA02536.1 - 3e-05 23.0 0.0 6.1e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 ESA02536.1 - 0.00024 20.8 0.3 0.0018 18.0 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA02536.1 - 0.00025 21.0 0.0 0.0016 18.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 ESA02536.1 - 0.00051 19.1 0.0 0.001 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 ESA02536.1 - 0.0043 16.9 0.0 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESA02536.1 - 0.0051 15.9 0.3 0.21 10.6 0.1 2.5 2 1 1 3 3 3 1 KaiC AAA_19 PF13245.1 ESA02536.1 - 0.0064 16.2 0.3 0.015 15.0 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_18 PF13238.1 ESA02536.1 - 0.0066 16.7 0.0 0.019 15.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 ESA02536.1 - 0.0066 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESA02536.1 - 0.0068 16.2 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA02536.1 - 0.0072 17.1 1.0 0.016 16.0 0.1 2.1 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 ESA02536.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 ESA02536.1 - 0.017 14.5 1.3 2 7.7 0.2 2.6 2 1 1 3 3 2 0 AAA domain AAA_28 PF13521.1 ESA02536.1 - 0.02 14.8 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain CtIP_N PF10482.4 ESA02536.1 - 0.021 14.6 0.5 0.049 13.4 0.3 1.5 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain NACHT PF05729.7 ESA02536.1 - 0.028 14.0 0.1 0.43 10.2 0.1 2.3 1 1 0 2 2 2 0 NACHT domain NB-ARC PF00931.17 ESA02536.1 - 0.028 13.2 0.1 0.067 12.0 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.7 ESA02536.1 - 0.044 12.8 0.0 0.073 12.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF2075 PF09848.4 ESA02536.1 - 0.069 12.1 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.8 ESA02536.1 - 0.069 11.8 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus RNA_helicase PF00910.17 ESA02536.1 - 0.081 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.13 ESA02536.1 - 0.082 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.16 ESA02536.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 ESA02536.1 - 0.15 11.6 0.2 0.38 10.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain PPTA PF01239.17 ESA02537.1 - 1.7e-47 156.8 21.4 1.3e-12 46.4 0.1 6.2 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat PSCyt2 PF07583.6 ESA02537.1 - 0.069 12.6 6.8 0.099 12.1 1.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1549) TPR_16 PF13432.1 ESA02537.1 - 0.089 13.4 0.0 0.22 12.2 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Arf PF00025.16 ESA02538.1 - 8.8e-46 155.3 0.1 1.1e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESA02538.1 - 3.6e-22 78.4 0.0 4.4e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA02538.1 - 1.2e-12 48.3 0.0 2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 ESA02538.1 - 1.6e-10 40.5 0.0 1.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESA02538.1 - 1.4e-09 37.4 0.0 1.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ESA02538.1 - 3.8e-08 32.4 0.8 2.1e-06 26.6 0.0 2.3 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.18 ESA02538.1 - 4.8e-08 32.9 0.1 1.2e-07 31.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA02538.1 - 1e-05 25.1 0.0 0.00032 20.2 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESA02538.1 - 0.0015 18.3 0.2 0.5 10.1 0.2 2.2 1 1 1 2 2 2 2 Dynamin family AAA_22 PF13401.1 ESA02538.1 - 0.0039 17.3 0.1 0.017 15.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain cobW PF02492.14 ESA02538.1 - 0.016 14.6 0.2 3.9 6.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 ESA02538.1 - 0.054 13.7 0.0 0.1 12.8 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESA02538.1 - 0.061 13.6 0.7 0.19 12.0 0.5 1.7 1 1 0 1 1 1 0 ABC transporter MobB PF03205.9 ESA02538.1 - 0.072 12.7 0.3 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.13 ESA02538.1 - 0.095 11.9 1.3 0.18 11.0 0.0 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B ACT PF01842.20 ESA02538.1 - 0.11 12.0 0.0 0.3 10.6 0.0 1.8 1 0 0 1 1 1 0 ACT domain Sod_Cu PF00080.15 ESA02539.1 - 2.7e-50 170.1 3.1 3.1e-50 170.0 2.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) zf-CCCH PF00642.19 ESA02540.1 - 9e-05 22.0 1.6 0.0021 17.6 0.8 3.3 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Viral_cys_rich PF08008.7 ESA02540.1 - 0.46 10.0 5.7 0.57 9.7 3.9 1.3 1 0 0 1 1 1 0 Viral cysteine rich Crisp PF08562.5 ESA02540.1 - 2.1 8.6 7.7 1.8 8.9 2.8 2.3 1 1 1 2 2 2 0 Crisp Histone PF00125.19 ESA02542.1 - 3.8e-19 68.5 0.0 5.1e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA02542.1 - 0.0041 17.1 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone E1_DerP2_DerF2 PF02221.10 ESA02543.1 - 4.9e-10 39.7 0.2 6.1e-10 39.4 0.1 1.1 1 0 0 1 1 1 1 ML domain PdxJ PF03740.8 ESA02544.1 - 0.094 11.8 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ ATP-cone PF03477.11 ESA02544.1 - 0.26 11.7 0.0 0.26 11.7 0.0 2.1 3 0 0 3 3 3 0 ATP cone domain AAA_35 PF14516.1 ESA02548.1 - 4.3e-08 32.1 0.3 6e-08 31.6 0.2 1.2 1 0 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 ESA02548.1 - 2.8e-06 27.4 0.0 5.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA02548.1 - 1.8e-05 24.5 0.7 3.6e-05 23.6 0.1 1.7 2 0 0 2 2 2 1 Archaeal ATPase AAA_14 PF13173.1 ESA02548.1 - 0.00083 19.2 2.8 0.0031 17.3 0.4 2.8 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESA02548.1 - 0.0016 17.8 0.1 0.25 10.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESA02548.1 - 0.004 17.3 0.0 0.01 16.0 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA02548.1 - 0.02 14.9 0.0 0.043 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain SieB PF14163.1 ESA02548.1 - 0.066 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Superinfection exclusion protein B NOD PF06816.8 ESA02549.1 - 0.0093 15.0 0.0 0.02 13.9 0.0 1.6 1 0 0 1 1 1 1 NOTCH protein NOD PF06816.8 ESA02550.1 - 0.014 14.4 0.0 0.043 12.8 0.0 1.9 2 0 0 2 2 2 0 NOTCH protein GerE PF00196.14 ESA02551.1 - 0.02 14.1 0.1 0.045 13.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family MADF_DNA_bdg PF10545.4 ESA02551.1 - 0.24 11.6 3.5 22 5.3 0.0 3.9 4 0 0 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF543 PF04418.7 ESA02552.1 - 4.6e-26 90.5 0.2 1e-25 89.4 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF543) SGT1 PF07093.6 ESA02552.1 - 0.0076 14.6 0.1 0.0079 14.6 0.1 1.0 1 0 0 1 1 1 1 SGT1 protein Enhancin PF03272.8 ESA02552.1 - 0.017 13.1 2.0 0.019 12.9 1.4 1.0 1 0 0 1 1 1 0 Viral enhancin protein DUF2407_C PF13373.1 ESA02552.1 - 0.086 12.7 0.4 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Rhomboid PF01694.17 ESA02553.1 - 5.4e-11 42.7 9.4 9.4e-11 41.9 6.5 1.4 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.5 ESA02553.1 - 4.8 7.5 7.9 0.31 11.3 1.6 1.9 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) Alba PF01918.16 ESA02554.1 - 2e-13 49.7 0.6 3.6e-13 48.8 0.4 1.5 1 0 0 1 1 1 1 Alba AAA_12 PF13087.1 ESA02555.1 - 2.5e-23 82.5 0.0 5.7e-23 81.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA02555.1 - 1.9e-08 34.1 0.0 1.9e-08 34.1 0.0 3.3 3 1 0 3 3 3 1 AAA domain SpoVIF PF14069.1 ESA02555.1 - 0.012 15.3 1.9 0.064 12.9 0.1 2.8 2 0 0 2 2 2 0 Stage VI sporulation protein F DUF445 PF04286.7 ESA02557.1 - 0.2 11.1 3.2 2.1 7.8 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF445) SpoU_sub_bind PF08032.7 ESA02557.1 - 0.31 11.2 1.9 1.2 9.3 0.2 2.4 2 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Pkinase PF00069.20 ESA02559.1 - 6.5e-10 38.6 0.0 9.1e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02559.1 - 2.2e-08 33.4 0.0 2.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RicinB_lectin_2 PF14200.1 ESA02560.1 - 0.0037 17.5 4.8 0.0052 17.1 0.9 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_72 PF03198.9 ESA02560.1 - 0.19 10.7 1.0 1.9 7.4 0.2 2.1 1 1 1 2 2 2 0 Glucanosyltransferase U79_P34 PF03064.11 ESA02561.1 - 0.76 9.2 9.5 1.4 8.3 6.6 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Sel1 PF08238.7 ESA02562.1 - 6e-33 112.5 0.0 4.4e-11 43.0 0.0 3.1 3 0 0 3 3 3 3 Sel1 repeat Prenyltrans_1 PF13243.1 ESA02562.1 - 0.0026 17.7 0.1 0.29 11.1 0.1 2.1 1 1 0 1 1 1 1 Prenyltransferase-like Antig_Caf1 PF09255.5 ESA02562.1 - 0.046 13.6 0.2 0.37 10.6 0.0 1.9 1 1 1 2 2 2 0 Caf1 Capsule antigen TPR_2 PF07719.12 ESA02562.1 - 0.13 12.2 0.3 5.2 7.2 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA02562.1 - 0.14 12.3 0.3 5.9 7.0 0.0 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat YvbH_ext PF11724.3 ESA02562.1 - 0.35 10.5 5.5 1.1 9.0 0.6 2.8 1 1 2 3 3 3 0 YvbH-like oligomerisation region AAA_17 PF13207.1 ESA02563.1 - 1.1e-05 26.2 1.2 0.00024 21.8 0.8 2.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA02563.1 - 1.2e-05 25.6 6.6 1.3e-05 25.5 1.2 2.7 2 1 0 2 2 2 1 AAA domain PRK PF00485.13 ESA02563.1 - 0.048 13.2 0.2 0.17 11.3 0.2 1.9 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 ESA02563.1 - 0.064 13.1 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain GIDA_assoc_3 PF13932.1 ESA02563.1 - 0.12 12.4 0.1 7.5 6.7 0.1 2.3 2 0 0 2 2 2 0 GidA associated domain 3 AAA_28 PF13521.1 ESA02563.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain CPT PF07931.7 ESA02563.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Pkinase PF00069.20 ESA02564.1 - 4.8e-33 114.3 0.0 7e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02564.1 - 1.6e-30 106.0 0.0 2.3e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA02564.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF202 PF02656.10 ESA02565.1 - 6.9e-10 39.0 0.8 6.9e-10 39.0 0.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Pkinase PF00069.20 ESA02566.1 - 8.2e-33 113.6 0.0 2.5e-25 89.1 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02566.1 - 4e-17 62.1 0.0 8.4e-07 28.3 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA02567.1 - 1.1e-25 90.3 0.0 1.2e-25 90.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02567.1 - 2.5e-24 85.7 0.0 3e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA02568.1 - 0.00021 20.4 0.0 0.00032 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02568.1 - 0.016 14.3 0.1 0.038 13.1 0.1 1.7 1 1 0 1 1 1 0 Protein kinase domain C1_2 PF03107.11 ESA02568.1 - 0.043 13.9 4.6 0.13 12.4 3.2 1.8 1 1 0 1 1 1 0 C1 domain Mvb12 PF09452.5 ESA02568.1 - 0.17 12.0 2.0 0.27 11.4 0.8 1.7 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 zf-C2H2_6 PF13912.1 ESA02568.1 - 6.3 6.8 6.2 3.6 7.6 1.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger IL6 PF00489.12 ESA02569.1 - 0.0072 15.9 0.0 0.0094 15.5 0.0 1.1 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family Ribonucleas_3_3 PF14622.1 ESA02570.1 - 4.3e-32 110.7 0.1 5.7e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 ESA02570.1 - 3.1e-21 75.9 0.0 6.2e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.20 ESA02570.1 - 5.8e-17 62.0 0.0 9.2e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ESA02570.1 - 5.8e-08 32.9 0.0 9.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 Dynamin_N PF00350.18 ESA02571.1 - 7.8e-16 58.3 0.1 7.8e-16 58.3 0.1 4.3 2 1 1 3 3 3 1 Dynamin family MMR_HSR1 PF01926.18 ESA02571.1 - 5.6e-07 29.5 4.8 0.00033 20.5 0.0 4.1 3 1 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA02571.1 - 8.7e-05 22.5 0.0 0.00032 20.7 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESA02571.1 - 0.00067 18.8 0.0 0.0028 16.8 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESA02571.1 - 0.001 19.1 0.3 0.41 10.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 ESA02571.1 - 0.0015 18.0 0.0 0.0033 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESA02571.1 - 0.0045 17.2 0.1 0.0045 17.2 0.1 4.1 4 1 1 5 5 5 1 ABC transporter Inhibitor_G39P PF11417.3 ESA02571.1 - 0.016 15.2 1.2 0.52 10.3 0.3 3.2 2 0 0 2 2 2 0 Loader and inhibitor of phage G40P Miro PF08477.8 ESA02571.1 - 0.016 15.6 0.0 0.016 15.6 0.0 4.2 4 1 0 4 4 4 0 Miro-like protein FtsK_SpoIIIE PF01580.13 ESA02571.1 - 0.023 14.1 0.2 0.079 12.4 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family IR1-M PF12185.3 ESA02571.1 - 0.047 13.3 2.4 0.58 9.9 0.3 3.0 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain NACHT PF05729.7 ESA02571.1 - 0.54 9.8 2.9 2.2 7.9 0.1 3.1 2 1 0 2 2 2 0 NACHT domain AAA_17 PF13207.1 ESA02571.1 - 0.57 11.0 0.0 0.57 11.0 0.0 4.6 3 1 0 4 4 3 0 AAA domain DUF883 PF05957.8 ESA02571.1 - 5 7.5 6.4 4.5 7.7 0.1 3.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) Piwi PF02171.12 ESA02572.1 - 8e-101 336.9 0.0 1.2e-100 336.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA02572.1 - 7.8e-23 80.2 0.1 1.8e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA02572.1 - 4.5e-18 64.3 0.0 1e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Tantalus PF15386.1 ESA02573.1 - 0.023 14.4 0.1 0.031 14.0 0.1 1.3 1 0 0 1 1 1 0 Drosophila Tantalus-like Pkinase PF00069.20 ESA02574.1 - 7.7e-47 159.6 0.3 7.7e-47 159.6 0.2 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02574.1 - 1.7e-46 158.3 0.0 2.9e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA02574.1 - 0.00033 19.7 0.1 0.00071 18.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA02574.1 - 0.02 14.2 2.7 0.086 12.1 1.9 2.0 1 1 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 ESA02574.1 - 0.029 13.6 0.2 0.084 12.2 0.1 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ESA02574.1 - 0.089 12.5 1.8 0.34 10.6 1.1 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA02575.1 - 8.8e-05 22.1 3.6 0.0008 19.0 2.5 2.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA02575.1 - 0.0043 16.6 5.6 0.026 14.1 3.9 2.5 1 0 0 1 1 1 1 F-box domain Pox_A3L PF05288.6 ESA02575.1 - 0.043 13.5 1.0 0.28 10.9 0.1 2.7 2 0 0 2 2 2 0 Poxvirus A3L Protein LRR_4 PF12799.2 ESA02578.1 - 0.063 12.9 0.3 0.21 11.2 0.2 2.0 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) Neuregulin PF02158.10 ESA02578.1 - 0.16 10.7 0.1 0.2 10.4 0.1 1.1 1 0 0 1 1 1 0 Neuregulin family LRR_8 PF13855.1 ESA02578.1 - 0.28 10.9 1.6 0.69 9.7 0.4 2.1 1 1 1 2 2 2 0 Leucine rich repeat LRR_6 PF13516.1 ESA02578.1 - 0.32 11.1 3.9 7.8 6.9 0.2 3.1 3 1 0 3 3 3 0 Leucine Rich repeat CRIC_ras_sig PF10534.4 ESA02579.1 - 0.036 14.1 0.1 0.051 13.6 0.1 1.2 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras Exo_endo_phos PF03372.18 ESA02580.1 - 1.9e-07 31.2 0.0 2.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SurA_N_2 PF13623.1 ESA02580.1 - 0.0073 16.2 0.2 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 SurA N-terminal domain Exo_endo_phos PF03372.18 ESA02581.1 - 0.00045 20.2 0.0 0.0014 18.6 0.0 1.7 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.22 ESA02581.1 - 0.00065 19.1 0.3 0.38 10.0 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.21 ESA02582.1 - 0.0095 16.2 4.6 0.017 15.4 1.9 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type PUF PF00806.14 ESA02582.1 - 0.012 15.0 0.1 0.032 13.7 0.0 1.7 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat DDE_3 PF13358.1 ESA02583.1 - 3e-07 30.3 0.1 3.9e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Myb_DNA-bind_5 PF13873.1 ESA02583.1 - 0.037 13.9 0.1 0.054 13.4 0.1 1.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Sel1 PF08238.7 ESA02585.1 - 1.6e-14 53.9 0.1 4.1e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Sel1 repeat TPR_5 PF12688.2 ESA02585.1 - 0.047 13.7 0.2 6.2 6.8 0.0 2.0 1 1 1 2 2 2 0 Tetratrico peptide repeat Pkinase PF00069.20 ESA02586.1 - 2.4e-21 76.0 3.1 4.6e-21 75.1 2.2 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02586.1 - 3.8e-15 55.6 0.0 7.4e-15 54.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase EcoEI_R_C PF08463.5 ESA02586.1 - 0.11 12.3 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 EcoEI R protein C-terminal Sel1 PF08238.7 ESA02587.1 - 1.8e-06 28.3 0.3 3.5e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Sel1 repeat TPR_2 PF07719.12 ESA02587.1 - 0.2 11.6 1.2 0.46 10.5 0.6 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat Dna2 PF08696.6 ESA02588.1 - 0.024 13.9 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 DNA replication factor Dna2 DUF3912 PF13051.1 ESA02590.1 - 0.09 12.5 0.1 0.25 11.1 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3912) DUF3604 PF12228.3 ESA02590.1 - 0.14 10.3 0.1 0.15 10.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) DUF2235 PF09994.4 ESA02592.1 - 2.6e-26 92.6 0.0 2.7e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ESA02592.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sel1 PF08238.7 ESA02596.1 - 2.5e-137 444.3 48.1 1.2e-10 41.6 0.0 14.0 14 0 0 14 14 14 14 Sel1 repeat TPR_16 PF13432.1 ESA02596.1 - 7.7e-10 39.1 1.0 0.067 13.8 0.0 7.9 6 2 2 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA02596.1 - 3.2e-07 30.3 9.1 0.68 10.5 0.0 8.2 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA02596.1 - 0.0013 18.2 5.6 0.0013 18.2 3.9 10.7 2 1 12 14 14 14 3 TPR repeat TPR_17 PF13431.1 ESA02596.1 - 0.011 15.8 48.5 1.6 9.1 0.2 12.8 12 2 1 13 13 13 0 Tetratricopeptide repeat DUF296 PF03479.10 ESA02596.1 - 0.031 13.8 0.0 65 3.1 0.0 4.5 5 1 0 5 5 5 0 Domain of unknown function (DUF296) MIT PF04212.13 ESA02596.1 - 0.34 10.8 14.7 3.7 7.5 0.0 6.8 8 2 0 8 8 8 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 ESA02596.1 - 7.3 6.6 22.6 43 4.2 0.1 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat Dynamin_M PF01031.15 ESA02598.1 - 0.096 11.4 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 Dynamin central region BTB PF00651.26 ESA02600.1 - 1.1e-20 73.7 0.6 1.8e-19 69.7 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA02600.1 - 7.1e-08 32.5 0.0 1.2e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 SPRY domain Chitin_synth_2 PF03142.10 ESA02603.1 - 4.4e-190 632.5 4.0 5.9e-190 632.1 2.8 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.1 ESA02603.1 - 1.2e-16 61.1 0.0 6.5e-15 55.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESA02603.1 - 9.4e-15 54.8 10.2 9.4e-15 54.8 7.1 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.23 ESA02603.1 - 4.1e-12 45.7 0.2 1.5e-06 27.8 0.0 2.5 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 ESA02603.1 - 3.5e-05 23.1 0.0 0.00051 19.3 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 ESA02603.1 - 0.00038 20.1 0.4 0.022 14.4 0.0 3.0 3 0 0 3 3 3 1 Glycosyl transferase family 2 Ank PF00023.25 ESA02604.1 - 2.9e-14 52.0 0.2 3.5e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 ESA02604.1 - 2.1e-12 46.8 0.9 7e-06 26.1 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESA02604.1 - 3.6e-12 46.4 0.2 4.2e-12 46.2 0.1 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA02604.1 - 7.9e-11 41.1 0.2 0.00023 21.1 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 ESA02604.1 - 1.2e-10 41.6 0.6 1.5e-07 31.6 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) UBA PF00627.26 ESA02604.1 - 0.07 13.0 0.0 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 UBA/TS-N domain RRM_1 PF00076.17 ESA02605.1 - 3.5e-25 87.4 0.0 6e-15 54.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02605.1 - 2.8e-24 84.8 0.0 1.1e-15 57.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02605.1 - 3.1e-14 52.5 0.0 3e-08 33.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA02605.1 - 0.037 13.8 0.0 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif RNA_pol_I_A49 PF06870.7 ESA02607.1 - 2.3e-64 217.3 4.4 3e-64 217.0 3.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor YolD PF08863.5 ESA02607.1 - 0.071 12.9 1.0 1.7 8.5 0.0 3.1 3 0 0 3 3 3 0 YolD-like protein Phage_antitermQ PF06530.7 ESA02607.1 - 0.095 12.2 0.1 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 Phage antitermination protein Q DUF1903 PF08991.5 ESA02608.1 - 7.8e-07 29.1 1.6 1e-06 28.7 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) CHCH PF06747.8 ESA02608.1 - 5.3e-06 26.2 5.6 9.3e-06 25.4 3.8 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ESA02608.1 - 0.025 14.6 4.0 0.029 14.4 2.8 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 tRNA_lig_kinase PF08303.6 ESA02608.1 - 0.086 12.7 0.5 0.1 12.4 0.4 1.0 1 0 0 1 1 1 0 tRNA ligase kinase domain UPF0203 PF05254.7 ESA02608.1 - 0.1 12.4 4.3 0.32 10.8 3.0 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) GCK PF07802.6 ESA02608.1 - 0.15 12.2 2.2 0.22 11.6 0.5 1.9 1 1 1 2 2 2 0 GCK domain Cmc1 PF08583.5 ESA02608.1 - 0.77 9.5 6.6 1.9 8.3 4.6 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like LUC7 PF03194.10 ESA02609.1 - 7.4e-60 202.6 6.4 9.1e-60 202.3 4.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF2225 PF09986.4 ESA02609.1 - 0.0044 16.5 1.3 0.8 9.1 0.5 2.2 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) KMP11 PF03037.11 ESA02609.1 - 0.0048 17.4 2.3 0.1 13.2 0.4 2.5 1 1 1 2 2 2 1 Kinetoplastid membrane protein 11 zf-C3HC PF07967.8 ESA02609.1 - 0.018 14.7 0.5 0.048 13.4 0.0 1.9 2 0 0 2 2 2 0 C3HC zinc finger-like zf-U1 PF06220.7 ESA02609.1 - 0.13 11.8 1.3 0.22 11.1 0.1 2.0 2 0 0 2 2 2 0 U1 zinc finger zf-met PF12874.2 ESA02609.1 - 0.5 10.6 3.2 1.5 9.1 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Wbp11 PF09429.5 ESA02609.1 - 5.2 7.1 7.7 0.33 10.9 0.3 2.5 2 1 1 3 3 3 0 WW domain binding protein 11 TPR_11 PF13414.1 ESA02611.1 - 3.6e-29 100.2 12.8 5.3e-12 45.2 0.0 4.3 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 ESA02611.1 - 3.1e-25 86.6 4.0 3.5e-08 32.7 0.0 5.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESA02611.1 - 1.2e-23 81.0 4.5 7.6e-07 28.5 0.0 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA02611.1 - 1.4e-17 63.8 5.0 2e-07 31.4 0.0 3.9 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESA02611.1 - 1.4e-16 59.2 3.7 0.0035 17.4 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA02611.1 - 1.4e-15 56.3 2.7 2.9e-05 24.3 0.0 5.2 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA02611.1 - 2.6e-13 49.6 4.9 1.2e-06 28.2 0.0 3.8 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA02611.1 - 6.6e-13 48.7 1.8 0.00087 19.5 0.0 3.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA02611.1 - 6.8e-12 44.2 0.7 0.00049 19.6 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA02611.1 - 1e-10 40.5 1.6 0.0045 16.6 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA02611.1 - 1.4e-09 37.9 0.0 0.034 14.2 0.0 4.2 2 2 1 4 4 4 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA02611.1 - 5.7e-09 35.9 3.4 0.00012 22.1 0.1 3.1 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESA02611.1 - 0.00012 21.8 2.0 0.083 12.7 0.1 3.7 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA02611.1 - 0.00014 21.0 0.1 0.093 11.7 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA02611.1 - 0.00023 21.3 5.2 1.4 9.5 0.0 5.9 6 2 0 6 6 6 1 Tetratricopeptide repeat MIT PF04212.13 ESA02611.1 - 0.00031 20.5 0.8 6.5 6.7 0.0 4.5 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 ESA02611.1 - 0.0015 18.3 0.0 4 7.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF1641 PF07849.6 ESA02611.1 - 0.12 11.9 0.2 0.23 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_10 PF13374.1 ESA02611.1 - 0.13 12.2 8.9 2.3 8.2 0.0 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat RRM_1 PF00076.17 ESA02612.1 - 1.2e-34 117.7 0.7 2.5e-14 52.6 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA02612.1 - 1.9e-25 88.6 0.0 1.7e-10 40.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA02612.1 - 2.4e-19 68.9 0.0 1.2e-05 25.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Birna_VP2 PF01766.12 ESA02613.1 - 0.28 10.0 2.2 0.32 9.8 1.5 1.1 1 0 0 1 1 1 0 Birnavirus VP2 protein Drc1-Sld2 PF11719.3 ESA02613.1 - 3.2 6.7 12.4 3.7 6.5 8.6 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein Mt_ATP-synt_B PF05405.9 ESA02615.1 - 2.2e-45 154.0 6.4 2.8e-45 153.7 4.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SapB_1 PF05184.10 ESA02615.1 - 0.022 14.5 0.3 0.055 13.3 0.2 1.7 1 0 0 1 1 1 0 Saposin-like type B, region 1 DUF4094 PF13334.1 ESA02615.1 - 0.1 13.0 1.5 0.38 11.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Uds1 PF15456.1 ESA02615.1 - 0.92 9.5 5.4 0.37 10.8 1.5 2.0 2 0 0 2 2 2 0 Up-regulated During Septation DivIC PF04977.10 ESA02615.1 - 0.95 8.9 5.2 1.1 8.8 0.1 2.6 2 0 0 2 2 2 0 Septum formation initiator TPR_MLP1_2 PF07926.7 ESA02615.1 - 1.8 8.3 7.9 6.5 6.5 5.5 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Methyltransf_31 PF13847.1 ESA02616.1 - 5e-10 39.1 0.5 1.3e-09 37.8 0.3 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA02616.1 - 2.5e-09 37.5 0.0 3.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA02616.1 - 5.3e-08 33.1 0.0 1.1e-07 32.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA02616.1 - 2e-07 30.5 0.0 2.5e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.1 ESA02616.1 - 2.7e-07 30.4 0.0 3.3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA02616.1 - 2.7e-07 31.1 0.2 2.1e-06 28.2 0.2 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA02616.1 - 1.9e-06 27.0 0.0 2.4e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 ESA02616.1 - 5.7e-05 23.1 0.0 6.1e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA02616.1 - 7.8e-05 22.6 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA02616.1 - 0.00017 22.0 0.1 0.00029 21.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESA02616.1 - 0.0002 20.6 0.0 0.00027 20.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.15 ESA02616.1 - 0.0016 17.6 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 ESA02616.1 - 0.016 14.3 0.0 0.051 12.6 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 ESA02616.1 - 0.045 13.1 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TehB PF03848.9 ESA02616.1 - 0.049 12.7 0.0 0.063 12.4 0.0 1.3 1 1 0 1 1 1 0 Tellurite resistance protein TehB Piwi PF02171.12 ESA02617.1 - 3.1e-98 328.4 0.0 4.5e-98 327.9 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA02617.1 - 3.2e-21 75.0 0.1 6.8e-21 73.9 0.1 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA02617.1 - 1.6e-17 62.5 0.0 3.2e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) DUF3245 PF11595.3 ESA02617.1 - 0.19 11.9 0.1 0.34 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Myb_DNA-bind_4 PF13837.1 ESA02619.1 - 2.9e-11 43.3 0.8 3.4e-11 43.1 0.5 1.0 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA02619.1 - 8.4e-09 35.9 0.9 9.4e-09 35.7 0.7 1.0 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA02619.1 - 0.00015 21.6 0.3 0.00022 21.0 0.2 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA02619.1 - 0.0039 17.3 0.3 0.0048 17.0 0.2 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_6 PF13921.1 ESA02619.1 - 0.055 13.5 1.1 0.081 13.0 0.8 1.4 1 1 0 1 1 1 0 Myb-like DNA-binding domain Retrotrans_gag PF03732.12 ESA02619.1 - 0.064 13.3 0.1 0.079 13.0 0.1 1.2 1 0 0 1 1 1 0 Retrotransposon gag protein SSPI PF14098.1 ESA02620.1 - 0.031 14.1 0.2 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Small, acid-soluble spore protein I DUF3482 PF11981.3 ESA02621.1 - 0.013 14.7 0.1 0.032 13.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) SM-ATX PF14438.1 ESA02621.1 - 0.053 13.4 0.4 3.3 7.6 0.0 2.8 2 1 0 2 2 2 0 Ataxin 2 SM domain BTB PF00651.26 ESA02624.1 - 1.7e-18 66.6 0.3 3.8e-18 65.4 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA02624.1 - 2e-11 44.0 0.1 4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA02625.1 - 7.3e-20 71.0 0.4 2.1e-19 69.5 0.2 1.9 1 1 1 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA02625.1 - 4.2e-15 55.9 0.1 8.3e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA02625.1 - 2e-06 27.8 0.1 2e-06 27.8 0.1 2.9 3 1 0 3 3 3 1 Skp1 family, tetramerisation domain BTB PF00651.26 ESA02626.1 - 3.2e-22 78.6 0.6 2.2e-21 75.8 0.1 2.2 1 1 1 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA02626.1 - 9.9e-14 51.4 0.1 2.1e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA02626.1 - 1.7e-05 24.7 0.3 0.00084 19.3 0.0 2.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain phiKZ_IP PF12699.2 ESA02627.1 - 0.0057 15.6 0.4 0.0059 15.5 0.3 1.0 1 0 0 1 1 1 1 phiKZ-like phage internal head proteins DUF4063 PF13272.1 ESA02627.1 - 0.071 12.9 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4063) DUF3201 PF11447.3 ESA02628.1 - 0.15 11.4 2.7 0.084 12.2 0.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3201) Cys_Met_Meta_PP PF01053.15 ESA02631.1 - 2.3e-17 62.3 0.2 2.4e-17 62.2 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ESA02631.1 - 0.003 16.6 0.1 0.0031 16.5 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 ESA02631.1 - 0.044 12.9 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Wzt_C PF14524.1 ESA02631.1 - 0.13 11.9 0.1 4.9 6.8 0.0 2.0 1 1 1 2 2 2 0 Wzt C-terminal domain Arf PF00025.16 ESA02632.1 - 2.1e-66 222.4 0.0 2.4e-66 222.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESA02632.1 - 4e-10 39.2 0.0 5.2e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 ESA02632.1 - 1.5e-09 37.0 0.1 3.7e-06 25.8 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 ESA02632.1 - 6.6e-08 32.0 0.0 7.6e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA02632.1 - 1.8e-06 28.4 0.0 2.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESA02632.1 - 2.4e-06 27.4 0.0 4.1e-06 26.7 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESA02632.1 - 9.3e-06 24.9 0.0 1e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 ESA02632.1 - 0.015 14.7 0.0 0.051 13.0 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF1691 PF07950.6 ESA02633.1 - 9.8e-12 44.7 0.9 3.5e-06 26.8 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF1691) G-gamma PF00631.17 ESA02634.1 - 3.1e-23 81.3 0.0 3.5e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 GGL domain SPT6_acidic PF14632.1 ESA02635.1 - 1.7 8.8 5.7 2.2 8.5 4.0 1.2 1 0 0 1 1 1 0 Acidic N-terminal SPT6 Zip PF02535.17 ESA02635.1 - 4.6 6.1 15.3 4.7 6.1 10.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter PDGF_N PF04692.8 ESA02635.1 - 4.8 7.7 7.0 5.2 7.6 4.9 1.3 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region MMgT PF10270.4 ESA02636.1 - 5.2e-20 71.8 0.1 6.3e-20 71.5 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter Adaptin_N PF01602.15 ESA02637.1 - 8.3e-129 430.2 6.9 1.2e-128 429.7 4.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 ESA02637.1 - 5.7e-12 45.8 1.6 1.6e-08 34.6 0.1 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESA02637.1 - 1.9e-07 31.2 0.2 0.23 11.7 0.0 5.0 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.17 ESA02637.1 - 1.9e-06 27.4 3.6 1.1 9.5 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat BLVR PF06375.6 ESA02637.1 - 6.5e-06 26.0 9.3 6.5e-06 26.0 6.4 4.9 2 1 2 4 4 4 1 Bovine leukaemia virus receptor (BLVR) Saccharop_dh PF03435.13 ESA02638.1 - 1e-78 265.0 0.0 3.3e-78 263.3 0.0 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase PRESAN PF09687.5 ESA02638.1 - 0.037 14.1 0.4 0.067 13.2 0.3 1.4 1 0 0 1 1 1 0 Plasmodium RESA N-terminal DnaJ_CXXCXGXG PF00684.14 ESA02639.1 - 0.0037 17.2 2.8 0.0079 16.2 1.9 1.4 1 0 0 1 1 1 1 DnaJ central domain zf-FPG_IleRS PF06827.9 ESA02639.1 - 0.16 11.6 0.9 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS DUF2360 PF10152.4 ESA02639.1 - 0.72 10.1 6.5 1.1 9.4 4.5 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) AHH PF14412.1 ESA02640.1 - 0.15 12.0 0.7 22 5.1 0.1 2.4 2 0 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Myb_DNA-binding PF00249.26 ESA02641.1 - 7.7e-05 22.6 0.1 0.00012 22.0 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA02641.1 - 0.0029 17.6 0.1 0.0056 16.7 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3337 PF11816.3 ESA02642.1 - 3.2e-73 247.0 19.2 3.9e-66 223.7 8.4 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF3337) WD40 PF00400.27 ESA02642.1 - 4.3e-35 118.3 24.2 3.2e-09 36.3 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat zf-C2H2 PF00096.21 ESA02643.1 - 1.4e-15 56.5 18.9 7.5e-06 25.9 1.9 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA02643.1 - 1.4e-12 47.2 17.4 5.1e-06 26.5 0.3 4.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA02643.1 - 1.4e-10 40.7 17.9 0.00015 21.8 2.1 3.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA02643.1 - 2.9e-05 23.8 8.3 0.034 14.0 0.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA02643.1 - 6.3e-05 22.9 9.4 0.09 12.9 0.4 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 ESA02643.1 - 0.051 13.5 7.4 0.34 10.9 1.4 3.2 1 1 2 3 3 3 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 ESA02643.1 - 0.056 13.2 7.9 0.059 13.1 1.6 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain C1_3 PF07649.7 ESA02643.1 - 0.087 12.8 3.5 2.9 8.0 0.0 3.1 3 0 0 3 3 3 0 C1-like domain zf-met PF12874.2 ESA02643.1 - 0.16 12.2 10.4 0.98 9.7 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF3280 PF11684.3 ESA02643.1 - 0.19 11.9 0.6 7.8 6.6 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2380) C1_4 PF07975.7 ESA02643.1 - 0.27 11.2 9.3 2.3 8.2 5.5 2.5 1 1 1 2 2 2 0 TFIIH C1-like domain zf-RING_3 PF14369.1 ESA02643.1 - 0.28 11.2 2.6 25 4.9 0.1 2.9 3 0 0 3 3 3 0 zinc-finger C1_1 PF00130.17 ESA02643.1 - 0.43 10.3 3.6 1.4 8.6 1.7 2.5 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-LYAR PF08790.6 ESA02643.1 - 0.54 9.9 4.9 36 4.1 0.1 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.2 ESA02643.1 - 0.56 10.3 8.9 3.4 7.8 0.4 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Myb_DNA-binding PF00249.26 ESA02644.1 - 0.0066 16.4 0.1 0.018 15.1 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Mak16 PF04874.9 ESA02644.1 - 0.012 15.6 0.6 0.018 15.1 0.4 1.4 1 0 0 1 1 1 0 Mak16 protein C-terminal region Myb_DNA-bind_6 PF13921.1 ESA02644.1 - 0.042 13.9 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF3192 PF11399.3 ESA02644.1 - 0.05 13.5 0.4 0.13 12.2 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3192) Eno-Rase_FAD_bd PF07055.7 ESA02644.1 - 0.1 12.5 0.3 0.29 11.1 0.2 1.7 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain DUF1922 PF09082.5 ESA02644.1 - 0.14 12.2 0.2 0.32 11.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) Pkinase PF00069.20 ESA02646.1 - 1.3e-61 208.0 0.3 5.3e-61 206.0 0.2 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02646.1 - 1e-22 80.4 0.0 3.6e-22 78.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.17 ESA02646.1 - 0.037 13.3 0.0 0.089 12.1 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA02646.1 - 0.07 12.1 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA02646.1 - 0.15 11.8 1.5 0.87 9.2 0.4 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Glyco_transf_21 PF13506.1 ESA02647.1 - 3e-36 124.3 0.0 6.1e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 ESA02647.1 - 2.9e-16 59.9 0.0 4.4e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESA02647.1 - 2.7e-10 40.3 0.9 2.7e-10 40.3 0.6 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 ESA02647.1 - 2.5e-06 27.3 0.0 4.8e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cys_rich_VLP PF14194.1 ESA02648.1 - 0.036 13.7 0.3 0.056 13.1 0.2 1.3 1 0 0 1 1 1 0 Cysteine-rich VLP DUF3702 PF12486.3 ESA02650.1 - 0.028 14.0 0.7 0.032 13.9 0.5 1.1 1 0 0 1 1 1 0 ImpA domain protein AKNA PF12443.3 ESA02650.1 - 0.055 13.4 0.2 0.071 13.1 0.2 1.1 1 0 0 1 1 1 0 AT-hook-containing transcription factor IFRD_C PF04836.7 ESA02650.1 - 0.081 13.1 2.9 0.13 12.4 2.0 1.4 1 1 0 1 1 1 0 Interferon-related protein conserved region GDA1_CD39 PF01150.12 ESA02651.1 - 0.061 11.8 0.9 0.065 11.7 0.6 1.0 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family SICA_alpha PF12887.2 ESA02651.1 - 0.061 13.0 0.0 0.07 12.8 0.0 1.1 1 0 0 1 1 1 0 SICA extracellular alpha domain Ureide_permease PF07168.6 ESA02651.1 - 0.089 11.4 0.0 0.099 11.2 0.0 1.0 1 0 0 1 1 1 0 Ureide permease DUF4199 PF13858.1 ESA02651.1 - 0.14 12.1 1.6 0.17 11.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Med31 PF05669.7 ESA02651.1 - 0.14 11.9 4.2 0.19 11.4 2.9 1.2 1 0 0 1 1 1 0 SOH1 Yip1 PF04893.12 ESA02652.1 - 1.5 8.3 11.2 0.93 8.9 0.5 3.1 2 1 0 3 3 3 0 Yip1 domain E1-E2_ATPase PF00122.15 ESA02652.1 - 3.2 6.7 8.6 3 6.8 1.2 2.9 2 1 0 2 2 2 0 E1-E2 ATPase Baculo_11_kDa PF06143.6 ESA02652.1 - 5.8 6.3 14.5 2.6 7.4 4.0 3.0 3 0 0 3 3 3 0 Baculovirus 11 kDa family TrbC PF04956.8 ESA02652.1 - 8.9 6.4 11.7 0.23 11.4 1.1 2.9 3 1 0 3 3 3 0 TrbC/VIRB2 family Pkinase_Tyr PF07714.12 ESA02653.1 - 0.0008 18.5 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02653.1 - 0.026 13.6 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DnaB_2 PF07261.6 ESA02653.1 - 0.035 13.7 0.1 0.072 12.6 0.0 1.6 1 1 0 1 1 1 0 Replication initiation and membrane attachment DUF4468 PF14730.1 ESA02653.1 - 0.22 11.2 3.2 0.48 10.1 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold Imm-NTF2 PF15655.1 ESA02654.1 - 0.047 14.1 4.1 0.072 13.5 2.9 1.2 1 0 0 1 1 1 0 NTF2 fold immunity protein Barwin PF00967.12 ESA02654.1 - 0.049 13.3 0.2 0.063 12.9 0.1 1.2 1 0 0 1 1 1 0 Barwin family DUF3889 PF13028.1 ESA02654.1 - 0.36 10.5 3.4 0.66 9.6 2.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3889) Coiled-coil_56 PF09813.4 ESA02654.1 - 0.49 10.4 4.6 0.82 9.6 3.2 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 KH_1 PF00013.24 ESA02656.1 - 0.028 14.0 0.7 0.071 12.7 0.5 1.7 1 0 0 1 1 1 0 KH domain Rad60-SLD_2 PF13881.1 ESA02660.1 - 0.055 13.3 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RNA_pol_Rpb1_4 PF05000.12 ESA02662.1 - 0.087 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Pkr1 PF08636.5 ESA02663.1 - 2.5e-07 30.6 5.9 4.3e-07 29.9 4.1 1.3 1 0 0 1 1 1 1 ER protein Pkr1 Pex26 PF07163.7 ESA02663.1 - 0.023 13.6 0.3 0.043 12.7 0.2 1.4 1 0 0 1 1 1 0 Pex26 protein DUF1814 PF08843.6 ESA02663.1 - 0.045 13.5 0.1 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF1814) Pkinase PF00069.20 ESA02664.1 - 2.6e-09 36.6 0.7 4.9e-09 35.7 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA02664.1 - 0.0028 17.0 0.0 0.0089 15.3 0.0 1.8 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL WaaY PF06176.6 ESA02664.1 - 0.0072 15.5 0.4 0.018 14.2 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA02664.1 - 0.057 13.1 0.0 1.4 8.5 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA02664.1 - 0.065 12.5 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.12 ESA02664.1 - 0.074 12.1 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.9 ESA02664.1 - 0.078 12.0 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4314 PF14192.1 ESA02665.1 - 0.13 12.5 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4314) Glu_synthase PF01645.12 ESA02667.1 - 8.3e-161 534.9 0.0 3.7e-160 532.8 0.0 1.9 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 ESA02667.1 - 1.3e-141 471.4 0.0 2e-141 470.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 ESA02667.1 - 3.5e-122 407.1 0.0 5.8e-122 406.4 0.0 1.4 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 ESA02667.1 - 5.6e-70 234.4 3.0 1e-69 233.5 2.1 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 ESA02667.1 - 3.4e-23 81.3 0.3 8.3e-23 80.1 0.2 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 ESA02667.1 - 8.8e-20 71.4 0.0 2.2e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESA02667.1 - 3.6e-11 43.5 0.1 0.00011 22.2 0.1 2.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA02667.1 - 8.3e-08 32.1 0.0 3.2e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 ESA02667.1 - 1.7e-07 31.5 0.3 0.00051 20.3 0.0 3.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESA02667.1 - 2.3e-05 23.4 4.5 0.0012 17.7 0.1 2.8 3 0 0 3 3 3 2 FAD binding domain HI0933_like PF03486.9 ESA02667.1 - 3.3e-05 22.5 4.2 3.7e-05 22.3 0.1 2.7 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.1 ESA02667.1 - 0.00012 22.2 0.7 0.26 11.5 0.1 3.2 3 0 0 3 3 2 1 Putative NAD(P)-binding GIDA PF01134.17 ESA02667.1 - 0.00032 19.6 0.5 0.019 13.8 0.1 2.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Amino_oxidase PF01593.19 ESA02667.1 - 0.00046 19.3 0.0 0.00084 18.5 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 ESA02667.1 - 0.001 18.0 0.1 0.001 18.0 0.0 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.18 ESA02667.1 - 0.0013 18.4 0.3 0.0064 16.2 0.0 2.3 3 0 0 3 3 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.16 ESA02667.1 - 0.0017 17.9 0.2 0.0065 16.0 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.2 ESA02667.1 - 0.0056 15.8 0.0 0.014 14.5 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 ESA02667.1 - 0.0066 15.5 0.1 0.018 14.1 0.0 1.7 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.14 ESA02667.1 - 0.0073 15.3 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DJ-1_PfpI PF01965.19 ESA02667.1 - 0.018 14.4 0.3 0.84 9.0 0.0 2.5 1 1 1 2 2 2 0 DJ-1/PfpI family FMN_dh PF01070.13 ESA02667.1 - 0.027 13.3 0.9 0.074 11.8 0.6 1.7 1 0 0 1 1 1 0 FMN-dependent dehydrogenase NAD_binding_2 PF03446.10 ESA02667.1 - 0.048 13.4 0.1 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 ESA02667.1 - 0.082 12.5 0.1 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 ESA02667.1 - 0.099 12.7 0.2 21 5.2 0.0 2.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PG_binding_2 PF08823.6 ESA02667.1 - 0.16 12.0 0.2 1.5 9.0 0.2 2.5 2 0 0 2 2 2 0 Putative peptidoglycan binding domain FMO-like PF00743.14 ESA02667.1 - 0.17 10.0 0.1 4.9 5.2 0.0 2.7 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like MULE PF10551.4 ESA02670.1 - 0.00012 22.1 0.1 0.0034 17.5 0.1 2.6 1 1 0 1 1 1 1 MULE transposase domain Spt4 PF06093.8 ESA02670.1 - 0.069 13.0 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger BTB PF00651.26 ESA02671.1 - 3.7e-14 52.6 0.4 6.3e-14 51.9 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02671.1 - 6.7e-10 39.0 0.0 1.7e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02671.1 - 1.1e-05 25.2 2.6 9e-05 22.2 0.1 3.2 3 1 1 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA02672.1 - 1.7e-17 63.4 0.0 2.8e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02672.1 - 3.7e-11 43.1 0.0 7.4e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02672.1 - 1.7e-08 34.2 0.5 8e-08 32.0 0.1 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch HIT PF01230.18 ESA02673.1 - 6.3e-25 87.5 0.3 7.9e-25 87.2 0.2 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESA02673.1 - 1.2e-13 51.2 0.1 1.9e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 ESA02673.1 - 2.8e-05 23.7 0.0 4.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 HSP70 PF00012.15 ESA02676.1 - 1.6e-15 56.0 7.7 1.7e-15 55.9 5.3 1.0 1 0 0 1 1 1 1 Hsp70 protein Ribosomal_S6 PF01250.12 ESA02676.1 - 0.099 12.5 1.0 0.18 11.6 0.7 1.4 1 0 0 1 1 1 0 Ribosomal protein S6 Herpes_UL92 PF03048.9 ESA02676.1 - 0.16 11.5 0.2 0.18 11.3 0.2 1.1 1 0 0 1 1 1 0 UL92 family SMK-1 PF04802.10 ESA02677.1 - 1.7e-68 229.9 9.2 1.7e-68 229.9 6.4 2.4 3 0 0 3 3 3 1 Component of IIS longevity pathway SMK-1 Ran_BP1 PF00638.13 ESA02677.1 - 0.00016 21.6 0.2 0.00084 19.3 0.0 2.4 3 0 0 3 3 3 1 RanBP1 domain Pkinase PF00069.20 ESA02679.1 - 9.5e-28 97.0 0.5 1.2e-27 96.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02679.1 - 2.8e-26 92.1 0.0 3.5e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA02679.1 - 0.00048 19.1 0.0 0.00062 18.8 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Sel1 PF08238.7 ESA02680.1 - 7.4e-41 137.6 8.8 1.4e-09 38.2 0.0 5.3 5 1 0 5 5 5 5 Sel1 repeat TPR_12 PF13424.1 ESA02680.1 - 1.2e-05 25.1 4.0 0.0028 17.5 0.3 4.2 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA02680.1 - 0.00088 18.8 2.5 0.00088 18.8 1.7 3.4 1 1 2 3 3 3 1 TPR repeat TPR_2 PF07719.12 ESA02680.1 - 0.0011 18.6 1.1 0.0011 18.6 0.8 6.2 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA02680.1 - 0.0027 17.2 3.1 0.0027 17.2 2.1 6.6 6 1 2 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA02680.1 - 0.0076 16.6 3.2 11 6.6 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RQC PF09382.5 ESA02680.1 - 0.0098 15.5 0.1 2.4 7.9 0.0 2.6 1 1 2 3 3 3 1 RQC domain TPR_10 PF13374.1 ESA02680.1 - 0.014 15.3 2.4 0.18 11.7 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA02680.1 - 0.085 12.6 0.3 3 7.6 0.0 2.5 2 1 0 2 2 2 0 Aurora-A binding PPR PF01535.15 ESA02680.1 - 0.13 12.2 0.7 2.8 8.1 0.1 2.9 3 0 0 3 3 3 0 PPR repeat MIT PF04212.13 ESA02680.1 - 0.14 12.0 8.4 3.1 7.7 0.4 3.4 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ESA02680.1 - 0.14 12.0 2.0 0.7 9.8 0.0 3.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA02680.1 - 0.33 11.2 7.3 4.3 7.7 0.2 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA02680.1 - 0.51 10.5 5.8 1.2 9.3 1.2 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MTBP_C PF14920.1 ESA02680.1 - 0.8 9.1 2.6 46 3.3 0.0 3.5 4 0 0 4 4 4 0 MDM2-binding SNAP PF14938.1 ESA02680.1 - 0.87 8.6 4.5 16 4.5 1.4 2.8 1 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP Sel1 PF08238.7 ESA02681.1 - 3.1e-50 167.4 16.9 2.3e-11 43.9 0.2 6.2 6 0 0 6 6 6 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA02681.1 - 1.4e-10 40.6 0.0 2.6e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02681.1 - 9.2e-06 24.9 0.0 2.6e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain MIT PF04212.13 ESA02681.1 - 0.17 11.7 21.3 1.5 8.7 1.2 5.5 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain HMG_box PF00505.14 ESA02683.1 - 1.3e-10 41.3 0.1 1.3e-10 41.3 0.1 1.9 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA02683.1 - 5.3e-06 26.7 0.1 5.3e-06 26.7 0.1 2.0 2 1 0 2 2 2 1 HMG-box domain FAM176 PF14851.1 ESA02683.1 - 0.54 9.9 3.1 0.99 9.0 2.2 1.4 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.7 ESA02683.1 - 1.5 8.6 7.4 1.9 8.3 5.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MAP65_ASE1 PF03999.7 ESA02683.1 - 3 6.3 14.8 4.1 5.8 10.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) GATase_4 PF13230.1 ESA02684.1 - 2e-19 69.3 0.1 4.9e-19 68.0 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 ESA02684.1 - 1.9e-11 44.0 0.0 3.7e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 ESA02684.1 - 1.7e-08 33.6 0.0 1e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_7 PF13537.1 ESA02684.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 Glutamine amidotransferase domain BTB PF00651.26 ESA02688.1 - 1.2e-15 57.3 1.0 3.2e-15 56.0 0.5 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA02688.1 - 1e-05 25.2 3.2 0.00048 19.9 0.1 3.6 3 2 1 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA02688.1 - 0.044 12.9 0.4 0.06 12.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Pkinase PF00069.20 ESA02689.1 - 2.7e-25 89.0 0.0 3e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02689.1 - 2.6e-21 75.8 0.0 3e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA02689.1 - 0.013 15.2 0.1 0.15 11.7 0.3 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DnaB_2 PF07261.6 ESA02690.1 - 0.047 13.2 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Replication initiation and membrane attachment UPF0231 PF06062.6 ESA02690.1 - 0.073 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) Pkinase PF00069.20 ESA02691.1 - 4.2e-13 49.0 1.2 2.1e-12 46.7 0.2 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02691.1 - 2.9e-06 26.5 0.1 1.2e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA02691.1 - 8.9e-06 25.6 0.2 2.2e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA02691.1 - 0.0011 18.6 0.4 0.0042 16.6 0.1 2.2 3 0 0 3 3 3 1 Choline/ethanolamine kinase Kdo PF06293.9 ESA02691.1 - 0.025 13.6 0.5 0.069 12.2 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIR PF02815.14 ESA02692.1 - 0.13 11.7 0.0 1.8 8.0 0.0 2.2 1 1 0 1 1 1 0 MIR domain TSGP1 PF07771.6 ESA02694.1 - 0.12 12.2 2.6 0.17 11.7 1.8 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 DUF3140 PF11338.3 ESA02695.1 - 0.098 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) DUF4179 PF13786.1 ESA02695.1 - 0.75 10.0 3.0 1.1 9.4 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) HTH_29 PF13551.1 ESA02698.1 - 0.00016 21.7 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 ESA02698.1 - 0.0002 21.3 0.2 0.00068 19.6 0.0 1.9 2 0 0 2 2 2 1 Transposase HTH_38 PF13936.1 ESA02698.1 - 0.0016 17.9 0.4 0.0055 16.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.1 ESA02698.1 - 0.0067 16.4 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA02698.1 - 0.014 15.0 0.1 0.041 13.5 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_27 PF13463.1 ESA02698.1 - 0.047 14.0 0.0 0.081 13.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_40 PF14493.1 ESA02698.1 - 0.052 13.7 0.1 0.076 13.2 0.1 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Peptidase_C1_2 PF03051.10 ESA02698.1 - 0.078 11.4 0.0 0.089 11.3 0.0 1.1 1 0 0 1 1 1 0 Peptidase C1-like family TrmB PF01978.14 ESA02698.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB AdoMet_MTase PF07757.8 ESA02704.1 - 9.9e-41 138.3 0.3 4.1e-40 136.3 0.1 1.9 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.1 ESA02704.1 - 0.00017 21.2 0.0 0.0011 18.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA02704.1 - 0.00075 20.0 0.0 0.0014 19.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA02704.1 - 0.0012 18.6 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA02704.1 - 0.0022 17.5 0.0 0.0046 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA02704.1 - 0.0027 17.1 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.9 ESA02704.1 - 0.037 13.4 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.7 ESA02704.1 - 0.052 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.17 ESA02705.1 - 0.0057 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) F-box-like PF12937.2 ESA02706.1 - 9.3e-06 25.2 1.1 9.3e-06 25.2 0.8 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA02706.1 - 0.006 16.2 1.1 0.023 14.3 0.2 2.4 2 0 0 2 2 2 1 F-box domain SRX PF09201.5 ESA02706.1 - 0.097 12.3 3.3 0.063 12.9 0.6 1.9 2 0 0 2 2 2 0 SRX AAA_35 PF14516.1 ESA02710.1 - 6.8e-12 44.6 0.0 1.4e-11 43.5 0.0 1.5 1 1 0 1 1 1 1 AAA-like domain AAA_14 PF13173.1 ESA02710.1 - 7.3e-06 25.9 0.2 7.3e-06 25.9 0.1 2.6 3 1 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 ESA02710.1 - 3.9e-05 23.4 0.2 0.00012 21.8 0.1 1.9 1 1 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA02710.1 - 5e-05 23.3 0.4 0.0046 16.9 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESA02710.1 - 0.00057 20.0 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESA02710.1 - 0.0021 18.2 0.0 0.005 17.0 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA02710.1 - 0.023 15.5 0.2 0.26 12.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESA02710.1 - 0.061 12.2 0.1 0.31 9.9 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 MobB PF03205.9 ESA02710.1 - 0.069 12.8 0.0 0.44 10.2 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 ESA02710.1 - 0.075 12.4 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RecA PF00154.16 ESA02710.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein DUF4488 PF14869.1 ESA02712.1 - 0.13 11.7 0.8 1.2 8.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4488) Pkinase_Tyr PF07714.12 ESA02713.1 - 1.2e-39 135.9 0.0 1.4e-39 135.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02713.1 - 4.3e-37 127.6 0.1 4.7e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain F-box-like PF12937.2 ESA02714.1 - 0.0016 18.1 1.3 0.0039 16.8 0.5 1.9 2 0 0 2 2 2 1 F-box-like Pkinase_Tyr PF07714.12 ESA02715.1 - 3.5e-32 111.5 0.0 4.1e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02715.1 - 3.2e-23 82.2 0.0 4.1e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain M11L PF11099.3 ESA02716.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.3 1 1 0 1 1 1 0 Apoptosis regulator M11L like AMP-binding PF00501.23 ESA02717.1 - 1.6e-61 207.9 0.0 1.3e-26 92.9 0.0 4.5 3 1 0 3 3 3 3 AMP-binding enzyme DMAP_binding PF06464.6 ESA02717.1 - 7.5e-11 42.6 0.4 2.1e-10 41.1 0.0 2.1 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.7 ESA02717.1 - 0.12 12.1 0.3 0.29 10.9 0.2 1.5 1 0 0 1 1 1 0 Gas vesicle protein G Clat_adaptor_s PF01217.15 ESA02718.1 - 2.1e-57 192.8 2.9 2.4e-57 192.6 2.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Sec3_C PF09763.4 ESA02719.1 - 1.1e-167 559.3 19.2 1.1e-167 559.3 13.3 1.6 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 ESA02719.1 - 4.2e-22 77.8 1.7 1.5e-21 76.0 0.9 2.2 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.7 ESA02719.1 - 2.2e-09 36.3 16.8 9.4e-08 31.0 5.6 2.4 2 0 0 2 2 2 2 Vps52 / Sac2 family HD PF01966.17 ESA02720.1 - 2.2e-15 56.7 0.6 3.8e-15 55.9 0.1 1.7 2 0 0 2 2 2 1 HD domain NPR2 PF06218.6 ESA02721.1 - 2.2e-139 464.8 9.1 5.9e-110 367.8 7.1 2.1 1 1 1 2 2 2 2 Nitrogen permease regulator 2 NPR3 PF03666.8 ESA02721.1 - 2.2e-08 33.0 0.6 0.00044 18.9 0.0 2.9 2 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 Sec5 PF15469.1 ESA02721.1 - 0.12 12.0 0.2 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Exocyst complex component Sec5 DUF489 PF04356.7 ESA02722.1 - 0.12 11.9 0.3 0.25 10.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF489) ApoLp-III PF07464.6 ESA02723.1 - 0.0087 16.0 1.5 0.0087 16.0 1.0 2.7 1 1 2 3 3 3 1 Apolipophorin-III precursor (apoLp-III) Fib_alpha PF08702.5 ESA02723.1 - 0.18 11.8 17.0 0.24 11.4 2.4 2.8 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family SlyX PF04102.7 ESA02723.1 - 0.31 11.4 8.7 1.9 8.9 1.8 2.8 1 1 1 2 2 2 0 SlyX PspB PF06667.7 ESA02723.1 - 1.5 8.8 8.0 9.6 6.2 0.4 2.7 2 0 0 2 2 2 0 Phage shock protein B YlqD PF11068.3 ESA02723.1 - 2.3 8.2 20.0 0.11 12.4 1.3 3.3 1 1 2 3 3 3 0 YlqD protein Spc24 PF08286.6 ESA02723.1 - 7.8 6.2 18.5 1.7 8.3 2.2 3.0 2 2 0 2 2 2 0 Spc24 subunit of Ndc80 Snapin_Pallidin PF14712.1 ESA02723.1 - 8 6.8 12.5 17 5.7 3.0 2.7 1 1 1 2 2 2 0 Snapin/Pallidin TPT PF03151.11 ESA02725.1 - 3.4e-33 114.4 13.0 3.4e-33 114.4 9.0 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 ESA02725.1 - 6.6e-08 31.8 25.4 1e-07 31.2 17.6 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESA02725.1 - 1.3e-07 31.7 32.3 0.00027 20.9 8.7 3.0 1 1 2 3 3 3 2 EamA-like transporter family RNase_H PF00075.19 ESA02726.1 - 5.6e-06 26.7 0.6 1.6e-05 25.2 0.1 1.8 2 0 0 2 2 2 1 RNase H DUF4249 PF14054.1 ESA02726.1 - 0.028 13.7 0.1 0.031 13.6 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) F-box-like PF12937.2 ESA02727.1 - 0.00018 21.1 2.9 0.00033 20.3 2.0 1.5 1 1 0 1 1 1 1 F-box-like BT1 PF03092.11 ESA02727.1 - 0.068 11.8 0.0 0.07 11.8 0.0 1.0 1 0 0 1 1 1 0 BT1 family IF2_N PF04760.10 ESA02728.1 - 0.15 11.7 1.1 0.43 10.2 0.7 1.8 1 1 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Pkinase_Tyr PF07714.12 ESA02729.1 - 1.7e-27 96.1 0.0 1.6e-26 92.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02729.1 - 1.9e-24 86.2 0.2 3.9e-24 85.2 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA02729.1 - 0.036 13.7 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YchF-GTPase_C PF06071.8 ESA02729.1 - 0.054 13.2 0.3 0.32 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF933) SAM_1 PF00536.25 ESA02730.1 - 0.095 12.8 2.3 1.2 9.4 0.1 2.9 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) EF-hand_4 PF12763.2 ESA02731.1 - 4.2e-44 148.5 0.5 4e-16 58.6 0.0 4.4 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 ESA02731.1 - 3.2e-10 38.5 0.0 0.00086 18.4 0.0 5.8 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 ESA02731.1 - 5.8e-10 39.1 0.1 0.00016 21.7 0.1 4.4 2 1 0 2 2 2 2 EF-hand domain pair UBA PF00627.26 ESA02731.1 - 1.4e-06 27.9 0.0 3.5e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_8 PF13833.1 ESA02731.1 - 1.6e-05 24.4 0.1 0.027 14.0 0.0 4.7 5 0 0 5 5 5 1 EF-hand domain pair EF-hand_6 PF13405.1 ESA02731.1 - 7e-05 22.3 0.1 1.5 8.8 0.0 5.5 5 0 0 5 5 5 1 EF-hand domain TPR_MLP1_2 PF07926.7 ESA02731.1 - 1.4 8.6 30.0 0.013 15.2 14.3 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Telomere_reg-2 PF10193.4 ESA02732.1 - 4e-35 120.5 0.0 1.3e-34 118.9 0.0 1.9 1 0 0 1 1 1 1 Telomere length regulation protein CAML PF14963.1 ESA02733.1 - 0.0008 18.8 0.5 0.0013 18.2 0.3 1.3 1 0 0 1 1 1 1 Calcium signal-modulating cyclophilin ligand FrpC PF06901.7 ESA02733.1 - 0.021 14.3 1.8 0.032 13.7 1.3 1.2 1 0 0 1 1 1 0 RTX iron-regulated protein FrpC Paramyxo_PCT PF14320.1 ESA02734.1 - 0.0035 16.3 2.9 0.0045 15.9 2.0 1.1 1 0 0 1 1 1 1 Phosphoprotein P region PCT disordered Rotamase_3 PF13616.1 ESA02735.1 - 5.9e-17 61.9 0.4 1.3e-16 60.8 0.3 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 ESA02735.1 - 1e-16 61.4 0.2 1.9e-16 60.5 0.0 1.5 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 ESA02735.1 - 5.8e-05 23.7 0.1 0.00012 22.6 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain F-box-like PF12937.2 ESA02737.1 - 0.0025 17.5 1.2 0.0025 17.5 0.8 3.2 4 0 0 4 4 4 1 F-box-like Lipoprotein_11 PF03260.8 ESA02737.1 - 0.012 14.5 0.2 0.026 13.5 0.1 1.5 1 0 0 1 1 1 0 Lepidopteran low molecular weight (30 kD) lipoprotein Spuma_A9PTase PF03539.9 ESA02744.1 - 2.6e-05 24.2 0.4 5.8e-05 23.0 0.3 1.7 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) Phage_Gp23 PF10669.4 ESA02744.1 - 2.5 8.2 6.8 0.43 10.7 0.1 2.5 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) Glycos_transf_N PF04413.11 ESA02745.1 - 0.059 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) DNA_ligase_A_M PF01068.16 ESA02746.1 - 0.016 14.5 0.2 0.02 14.2 0.1 1.1 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Sec2p PF06428.6 ESA02747.1 - 3.7e-08 33.1 3.2 3.7e-08 33.1 2.2 2.8 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Lig_chan PF00060.21 ESA02749.1 - 0.092 12.4 0.0 0.097 12.3 0.0 1.1 1 0 0 1 1 1 0 Ligand-gated ion channel Maff2 PF12750.2 ESA02751.1 - 0.15 11.6 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Maff2 family HMG_box PF00505.14 ESA02752.1 - 0.00069 19.8 0.0 0.0034 17.5 0.1 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box DUF2373 PF10180.4 ESA02753.1 - 0.021 14.3 3.9 0.025 14.0 0.6 2.5 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) BACK PF07707.10 ESA02753.1 - 0.055 13.3 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 BTB And C-terminal Kelch DUF3319 PF11782.3 ESA02754.1 - 0.082 12.7 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3319) Pkinase PF00069.20 ESA02756.1 - 3.7e-64 216.3 0.6 1.5e-63 214.3 0.0 2.2 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02756.1 - 1.3e-30 106.3 0.0 1.9e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA02756.1 - 7.9e-09 34.8 0.0 3.2e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 ESA02756.1 - 0.0061 15.4 0.4 0.011 14.5 0.3 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 LVIVD PF08309.6 ESA02756.1 - 0.024 13.6 0.0 0.06 12.3 0.0 1.6 1 0 0 1 1 1 0 LVIVD repeat APH PF01636.18 ESA02756.1 - 0.12 12.0 0.0 0.74 9.4 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Mod_r PF07200.8 ESA02757.1 - 0.017 15.0 5.7 0.019 14.8 3.9 1.0 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.4 ESA02757.1 - 0.017 15.0 7.4 0.02 14.7 5.1 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1779 PF08680.5 ESA02757.1 - 0.03 14.1 1.4 0.031 14.1 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1779) Golgin_A5 PF09787.4 ESA02757.1 - 0.072 11.6 3.4 0.075 11.5 2.3 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 WEMBL PF05701.6 ESA02757.1 - 0.076 11.4 5.6 0.15 10.5 3.9 1.5 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF4638 PF15472.1 ESA02757.1 - 0.081 12.5 0.3 0.088 12.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Filament PF00038.16 ESA02757.1 - 0.12 11.7 4.5 0.26 10.7 3.1 1.6 1 1 0 1 1 1 0 Intermediate filament protein MADF_DNA_bdg PF10545.4 ESA02757.1 - 0.13 12.4 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF745 PF05335.8 ESA02757.1 - 0.15 11.6 3.1 0.17 11.3 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Complex1_LYR_2 PF13233.1 ESA02757.1 - 0.17 12.4 0.8 0.19 12.2 0.5 1.2 1 0 0 1 1 1 0 Complex1_LYR-like TPR_MLP1_2 PF07926.7 ESA02757.1 - 0.17 11.6 4.5 0.18 11.5 3.1 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Med21 PF11221.3 ESA02757.1 - 0.18 11.7 3.5 0.14 12.0 0.6 1.8 1 1 1 2 2 2 0 Subunit 21 of Mediator complex Kinesin PF00225.18 ESA02758.1 - 1.3e-105 352.8 1.5 5.6e-105 350.7 1.0 1.8 1 1 0 1 1 1 1 Kinesin motor domain F-box-like PF12937.2 ESA02759.1 - 9.3e-07 28.4 0.9 2.5e-06 27.0 0.6 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA02759.1 - 0.068 12.8 0.1 0.068 12.8 0.1 5.4 3 3 1 4 4 4 0 Leucine Rich repeats (2 copies) BTB PF00651.26 ESA02761.1 - 1.6e-18 66.6 0.1 3.6e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02761.1 - 2.9e-10 40.3 2.3 2.9e-10 40.3 1.6 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02761.1 - 0.00074 19.3 0.7 0.0022 17.7 0.2 2.1 1 1 0 1 1 1 1 BTB And C-terminal Kelch GHMP_kinases_N PF00288.21 ESA02764.1 - 2.6e-10 40.1 0.4 5.5e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain Cullin_binding PF03556.10 ESA02765.1 - 0.037 14.1 0.2 0.051 13.7 0.1 1.2 1 0 0 1 1 1 0 Cullin binding Thioredoxin_6 PF13848.1 ESA02765.1 - 0.043 13.6 0.2 0.043 13.6 0.1 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain TLD PF07534.11 ESA02766.1 - 2e-12 47.2 0.2 2e-12 47.2 0.2 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02766.1 - 0.00021 21.0 0.3 0.00078 19.2 0.1 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch K1 PF02960.9 ESA02770.1 - 0.029 14.3 1.9 0.76 9.8 0.1 2.4 2 0 0 2 2 2 0 K1 glycoprotein RVP_2 PF08284.6 ESA02771.1 - 5.7e-07 29.5 0.0 1.8e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 ESA02771.1 - 1.7e-06 28.4 0.0 4.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.18 ESA02771.1 - 7.1e-06 25.7 0.6 1.2e-05 25.0 0.4 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease PF09668.5 ESA02771.1 - 1.2e-05 24.8 0.1 5.7e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA02771.1 - 0.0002 21.1 0.0 0.00054 19.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 ESA02771.1 - 0.038 13.9 0.6 0.24 11.3 0.1 2.4 2 0 0 2 2 2 0 Retroviral aspartyl protease CDC45 PF02724.9 ESA02771.1 - 0.54 8.2 11.0 0.91 7.4 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein F-box-like PF12937.2 ESA02774.1 - 0.0023 17.5 0.4 0.0068 16.1 0.3 1.8 1 0 0 1 1 1 1 F-box-like Chromo PF00385.19 ESA02775.1 - 7.9e-08 31.8 0.1 1.3e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain F-box-like PF12937.2 ESA02776.1 - 0.0008 19.0 0.2 0.0027 17.4 0.2 1.9 1 0 0 1 1 1 1 F-box-like SporV_AA PF12164.3 ESA02776.1 - 0.069 13.1 4.9 0.095 12.6 0.4 2.8 2 0 0 2 2 2 0 Stage V sporulation protein AA EF-hand_1 PF00036.27 ESA02777.1 - 6.1e-22 75.2 24.6 6.1e-06 25.1 0.3 6.7 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.1 ESA02777.1 - 2.6e-20 72.3 15.3 6.4e-08 32.6 0.4 4.0 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 ESA02777.1 - 3.7e-20 69.9 18.4 0.00026 20.5 0.0 7.3 8 0 0 8 8 8 5 EF-hand domain EF-hand_8 PF13833.1 ESA02777.1 - 1.2e-15 56.8 11.2 2.3e-05 23.9 0.1 5.4 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA02777.1 - 1.4e-15 55.7 19.6 0.00012 21.2 0.0 5.9 6 0 0 6 6 6 4 EF hand EF-hand_4 PF12763.2 ESA02777.1 - 1.8e-09 37.2 8.9 0.47 10.2 0.0 5.5 2 2 4 6 6 6 4 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA02777.1 - 0.00048 20.1 0.3 0.035 14.1 0.0 3.0 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Fork_head PF00250.13 ESA02777.1 - 0.016 15.2 0.0 17 5.5 0.0 3.6 3 1 0 3 3 3 0 Fork head domain DUF3069 PF11269.3 ESA02777.1 - 0.057 13.4 0.1 1.6 8.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3069) DUF3909 PF13077.1 ESA02777.1 - 1.2 9.0 8.3 0.36 10.6 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3909) p25-alpha PF05517.7 ESA02777.1 - 7.6 6.7 9.4 3.9 7.7 0.0 3.7 4 0 0 4 4 4 0 p25-alpha AAA_5 PF07728.9 ESA02779.1 - 3.2e-130 428.6 0.2 2.7e-21 75.7 0.0 9.4 7 2 2 9 9 9 9 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESA02779.1 - 1.1e-32 112.3 0.0 4.8e-08 32.6 0.0 8.1 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 ESA02779.1 - 3.4e-28 98.4 0.1 0.00013 22.1 0.0 7.4 7 0 0 7 7 6 6 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA02779.1 - 3.3e-25 89.2 0.1 0.00044 21.0 0.0 7.1 6 0 0 6 6 6 5 AAA domain AAA_14 PF13173.1 ESA02779.1 - 9.5e-24 83.7 4.5 0.0003 20.7 0.0 8.8 7 1 1 8 8 7 5 AAA domain Sigma54_activat PF00158.21 ESA02779.1 - 4.3e-22 78.3 0.3 0.00099 18.6 0.0 7.5 6 1 1 7 7 7 4 Sigma-54 interaction domain AAA_22 PF13401.1 ESA02779.1 - 3.7e-21 75.6 8.8 0.0015 18.6 0.0 8.8 9 1 0 9 9 7 4 AAA domain AAA_16 PF13191.1 ESA02779.1 - 4.5e-21 75.6 7.6 0.0028 17.6 0.3 7.7 6 2 0 6 6 6 4 AAA ATPase domain AAA_18 PF13238.1 ESA02779.1 - 4.9e-21 75.3 4.1 0.0043 17.3 0.0 7.9 6 1 0 6 6 6 4 AAA domain Sigma54_activ_2 PF14532.1 ESA02779.1 - 1.5e-19 70.4 0.2 5.2e-05 23.3 0.0 7.0 7 0 0 7 7 6 2 Sigma-54 interaction domain AAA_33 PF13671.1 ESA02779.1 - 1.9e-17 63.5 0.1 0.2 11.5 0.0 7.5 6 1 0 6 6 6 4 AAA domain UPF0079 PF02367.12 ESA02779.1 - 4.6e-15 55.3 8.0 0.12 12.0 0.0 6.9 7 0 0 7 7 6 4 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 ESA02779.1 - 2.5e-14 53.5 2.4 0.23 11.3 0.0 6.2 6 0 0 6 6 6 4 AAA domain ABC_tran PF00005.22 ESA02779.1 - 9.4e-14 51.8 10.2 0.0083 16.4 0.0 7.8 6 1 0 6 6 6 2 ABC transporter Zeta_toxin PF06414.7 ESA02779.1 - 1.2e-13 50.6 0.2 0.16 11.0 0.0 6.3 6 0 0 6 6 6 3 Zeta toxin AAA_19 PF13245.1 ESA02779.1 - 3.6e-13 49.0 3.4 0.11 12.3 0.1 5.9 6 0 0 6 6 5 3 Part of AAA domain Miro PF08477.8 ESA02779.1 - 3.9e-13 49.9 3.8 0.56 10.7 0.0 6.7 6 0 0 6 6 6 3 Miro-like protein MobB PF03205.9 ESA02779.1 - 7.4e-12 45.1 3.3 0.034 13.8 0.0 6.4 6 0 0 6 6 6 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 ESA02779.1 - 2.9e-11 43.3 0.0 0.14 11.6 0.0 7.7 8 1 0 8 8 6 1 AAA domain DUF815 PF05673.8 ESA02779.1 - 6.1e-11 41.7 2.9 0.18 10.6 0.0 6.3 6 0 0 6 6 6 3 Protein of unknown function (DUF815) DUF258 PF03193.11 ESA02779.1 - 6.1e-11 41.7 1.8 0.54 9.4 0.0 6.0 6 0 0 6 6 6 2 Protein of unknown function, DUF258 PduV-EutP PF10662.4 ESA02779.1 - 7e-11 41.7 3.5 0.0043 16.5 0.0 6.3 6 0 0 6 6 6 2 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 ESA02779.1 - 1.2e-10 40.7 4.2 0.022 13.6 0.0 5.9 6 0 0 6 6 6 2 Type II/IV secretion system protein AAA_29 PF13555.1 ESA02779.1 - 3.9e-10 39.1 0.7 0.85 9.1 0.0 6.5 6 0 0 6 6 6 1 P-loop containing region of AAA domain NACHT PF05729.7 ESA02779.1 - 7.8e-10 38.6 3.9 0.28 10.8 0.0 6.2 6 0 0 6 6 6 2 NACHT domain RNA_helicase PF00910.17 ESA02779.1 - 1.4e-09 38.0 1.6 0.69 10.1 0.0 6.2 6 1 0 6 6 5 2 RNA helicase SRP54 PF00448.17 ESA02779.1 - 4.5e-08 32.7 1.8 0.067 12.6 0.0 5.3 6 0 0 6 6 5 2 SRP54-type protein, GTPase domain AAA_25 PF13481.1 ESA02779.1 - 3.3e-07 29.9 1.0 1.1 8.6 0.0 5.2 6 0 0 6 6 4 2 AAA domain RuvB_N PF05496.7 ESA02779.1 - 4e-07 29.3 6.6 3 6.8 0.0 6.9 9 0 0 9 9 8 0 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESA02779.1 - 8.3e-07 28.3 8.8 3 6.9 0.0 8.6 8 2 1 9 9 9 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.20 ESA02779.1 - 1.4e-06 27.9 0.0 0.63 9.5 0.0 5.0 5 0 0 5 5 5 2 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.18 ESA02779.1 - 1.8e-06 27.8 0.2 7.8 6.4 0.0 5.5 5 0 0 5 5 5 0 50S ribosome-binding GTPase AAA_11 PF13086.1 ESA02779.1 - 2.5e-06 27.2 0.5 2.1 7.8 0.0 5.3 6 0 0 6 6 4 1 AAA domain AAA_2 PF07724.9 ESA02779.1 - 5.7e-06 26.3 2.6 6.7 6.5 0.0 6.1 7 0 0 7 7 5 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 ESA02779.1 - 1e-05 25.0 1.4 0.19 11.1 0.0 4.9 5 0 0 5 5 5 1 IstB-like ATP binding protein cobW PF02492.14 ESA02779.1 - 8e-05 22.1 11.6 1.1 8.6 0.0 6.1 7 0 0 7 7 5 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 ESA02779.1 - 0.00016 21.3 5.4 0.34 10.4 0.1 4.5 5 0 0 5 5 4 2 Conserved hypothetical ATP binding protein NTPase_1 PF03266.10 ESA02779.1 - 0.00032 20.4 6.2 5 6.7 0.1 5.7 6 0 0 6 6 5 0 NTPase AAA_24 PF13479.1 ESA02779.1 - 0.00056 19.5 0.4 17 4.9 0.0 5.1 5 0 0 5 5 5 0 AAA domain CbiA PF01656.18 ESA02779.1 - 0.00067 19.1 1.4 1.1 8.6 0.0 4.9 5 0 0 5 5 5 1 CobQ/CobB/MinD/ParA nucleotide binding domain CPT PF07931.7 ESA02779.1 - 0.0019 17.8 7.1 15 5.1 0.0 7.3 7 2 0 7 7 7 0 Chloramphenicol phosphotransferase-like protein MCM PF00493.18 ESA02779.1 - 0.0021 16.9 3.3 2.6 6.7 0.0 4.6 4 1 1 5 5 5 1 MCM2/3/5 family PhoH PF02562.11 ESA02779.1 - 0.0028 16.9 0.0 9.6 5.3 0.0 4.3 4 0 0 4 4 4 0 PhoH-like protein DEAD PF00270.24 ESA02779.1 - 0.0055 16.2 4.0 10 5.5 0.0 4.9 6 0 0 6 6 4 0 DEAD/DEAH box helicase ResIII PF04851.10 ESA02779.1 - 0.0082 15.9 8.9 0.4 10.4 0.8 4.5 4 1 0 4 4 3 1 Type III restriction enzyme, res subunit AAA_23 PF13476.1 ESA02779.1 - 0.01 16.1 30.6 0.81 9.9 0.0 7.2 7 1 0 7 7 6 0 AAA domain KaiC PF06745.8 ESA02779.1 - 0.013 14.6 3.5 10 5.1 0.0 5.0 6 1 0 6 6 6 0 KaiC TrwB_AAD_bind PF10412.4 ESA02779.1 - 0.016 13.8 3.0 3 6.3 0.0 4.3 5 0 0 5 5 4 0 Type IV secretion-system coupling protein DNA-binding domain AAA_6 PF12774.2 ESA02779.1 - 0.049 13.1 0.1 29 4.0 0.0 4.5 6 0 0 6 6 4 0 Hydrolytic ATP binding site of dynein motor region D1 PRK PF00485.13 ESA02779.1 - 0.052 13.1 0.4 15 5.0 0.0 3.8 4 0 0 4 4 3 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.18 ESA02779.1 - 0.082 12.7 3.6 8.4 6.1 0.0 4.5 5 0 0 5 5 4 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESA02779.1 - 0.18 11.2 1.9 12 5.3 0.0 3.7 4 0 0 4 4 4 0 FtsK/SpoIIIE family Dimer_Tnp_hAT PF05699.9 ESA02780.1 - 0.00018 21.0 0.2 0.00033 20.2 0.1 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region RIX1 PF08167.7 ESA02780.1 - 0.13 11.9 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis DUF956 PF06115.6 ESA02783.1 - 0.011 15.3 0.4 0.23 11.0 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF956) ADH_zinc_N PF00107.21 ESA02784.1 - 2.2e-22 78.9 0.0 4.1e-22 78.1 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PhoH PF02562.11 ESA02784.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ADH_zinc_N PF00107.21 ESA02785.1 - 7.7e-19 67.5 0.0 1.3e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA02785.1 - 0.013 16.4 0.0 0.028 15.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FAINT PF04385.10 ESA02786.1 - 0.11 12.3 1.1 0.33 10.8 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function, DUF529 TLD PF07534.11 ESA02787.1 - 3.2e-12 46.6 4.1 3.2e-12 46.6 2.8 2.2 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA02787.1 - 3.4e-11 43.1 0.1 7.1e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA02787.1 - 1.8e-05 24.4 2.7 5.3e-05 22.9 0.8 2.6 1 1 2 3 3 3 1 BTB And C-terminal Kelch RasGEF_N PF00618.15 ESA02787.1 - 0.02 14.9 0.6 0.02 14.9 0.4 2.6 2 1 0 2 2 2 0 RasGEF N-terminal motif BTB PF00651.26 ESA02788.1 - 6.9e-18 64.6 0.0 3e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA02788.1 - 7.6e-12 45.4 3.4 7.6e-12 45.4 2.4 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA02788.1 - 1.3e-07 31.3 3.6 8.7e-07 28.7 0.8 3.5 3 1 0 3 3 3 1 BTB And C-terminal Kelch COX16 PF14138.1 ESA02789.1 - 0.071 13.2 1.7 0.17 12.0 0.6 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein COX16 CBM_20 PF00686.14 ESA02790.1 - 0.0058 16.2 0.1 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain 2OG-FeII_Oxy_2 PF13532.1 ESA02791.1 - 2.2e-18 66.8 0.0 4.2e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SAD_SRA PF02182.12 ESA02791.1 - 0.044 13.0 0.1 0.044 13.0 0.1 1.7 2 0 0 2 2 2 0 SAD/SRA domain zf-C2HC5 PF06221.8 ESA02791.1 - 0.61 9.8 7.2 0.17 11.6 2.4 1.9 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type RTC4 PF14474.1 ESA02792.1 - 2.1e-17 63.2 0.1 4e-17 62.3 0.0 1.5 2 0 0 2 2 2 1 RTC4-like domain RP-C_C PF11800.3 ESA02793.1 - 0.11 12.2 1.0 0.13 11.9 0.7 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CDC45 PF02724.9 ESA02793.1 - 0.11 10.4 10.1 0.12 10.3 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.6 ESA02793.1 - 0.12 12.1 3.6 0.15 11.8 2.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RRN3 PF05327.6 ESA02793.1 - 0.19 9.7 6.9 0.21 9.6 4.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.7 ESA02793.1 - 0.48 9.4 18.6 0.58 9.2 12.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Hid1 PF12722.2 ESA02793.1 - 0.58 7.7 3.0 0.62 7.6 2.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pox_Ag35 PF03286.9 ESA02793.1 - 1.1 8.6 11.4 1.5 8.3 7.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.5 ESA02793.1 - 1.2 9.1 6.3 1.4 8.8 4.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TFIIA PF03153.8 ESA02793.1 - 1.4 8.7 9.4 1.5 8.6 6.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sporozoite_P67 PF05642.6 ESA02793.1 - 2.3 5.9 7.2 2.6 5.8 5.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF1510 PF07423.6 ESA02793.1 - 6.4 6.0 14.4 7.8 5.7 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Paf1 PF03985.8 ESA02793.1 - 7.4 5.1 15.7 8.8 4.9 10.9 1.1 1 0 0 1 1 1 0 Paf1 Hist_deacetyl PF00850.14 ESA02794.1 - 5.1e-29 101.5 0.1 6.4e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Pkinase_Tyr PF07714.12 ESA02795.1 - 3e-14 52.7 0.0 5.1e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02795.1 - 9.5e-08 31.4 0.5 2.6e-07 30.0 0.4 1.7 1 1 0 1 1 1 1 Protein kinase domain DUF2318 PF10080.4 ESA02795.1 - 0.049 13.4 0.2 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) SUR7 PF06687.7 ESA02795.1 - 0.31 10.5 1.9 0.36 10.3 1.4 1.3 1 0 0 1 1 1 0 SUR7/PalI family VWA_2 PF13519.1 ESA02796.1 - 9.7e-10 38.8 0.0 2.3e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA02796.1 - 8.3e-06 25.6 0.1 5.8e-05 22.8 0.1 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.4 ESA02796.1 - 8.9e-05 22.5 0.2 0.0028 17.6 0.0 3.2 2 1 0 2 2 2 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.9 ESA02796.1 - 0.042 12.9 0.0 0.17 10.9 0.0 2.0 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein NYD-SP28 PF14772.1 ESA02796.1 - 4.6 7.3 18.8 0.72 9.9 2.9 3.1 2 1 1 3 3 3 0 Sperm tail WGG PF10273.4 ESA02797.1 - 0.13 12.3 0.4 0.38 10.8 0.3 1.8 1 1 0 1 1 1 0 Pre-rRNA-processing protein TSR2 DUF2428 PF10350.4 ESA02798.1 - 1.9e-71 240.0 0.0 3.9e-71 239.0 0.0 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.17 ESA02798.1 - 7.2e-05 22.5 0.0 2.8 8.2 0.0 5.1 4 0 0 4 4 4 2 HEAT repeat ApoO PF09769.4 ESA02798.1 - 0.027 14.1 0.1 0.32 10.6 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein O Fib_alpha PF08702.5 ESA02799.1 - 0.017 15.2 0.2 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FCH PF00611.18 ESA02801.1 - 0.00033 20.7 8.6 0.0016 18.6 0.1 2.5 1 1 1 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4393 PF14337.1 ESA02801.1 - 0.0043 16.4 0.8 0.0091 15.4 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4393) DUF922 PF06037.6 ESA02801.1 - 0.0044 16.3 2.6 0.017 14.4 0.5 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF922) TerB-N PF13208.1 ESA02801.1 - 0.013 14.9 1.8 1.4 8.2 0.3 2.1 1 1 1 2 2 2 0 TerB-N Rsd_AlgQ PF04353.8 ESA02801.1 - 0.026 14.2 3.8 0.035 13.7 2.6 1.2 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Seryl_tRNA_N PF02403.17 ESA02801.1 - 0.039 13.9 9.0 0.76 9.8 3.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Lectin_N PF03954.9 ESA02801.1 - 0.05 12.9 0.6 0.092 12.1 0.4 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF3810 PF12725.2 ESA02801.1 - 0.099 11.5 3.8 0.066 12.1 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) PilJ PF13675.1 ESA02801.1 - 0.11 12.8 0.2 0.26 11.6 0.1 1.8 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2347 PF09804.4 ESA02801.1 - 0.12 11.6 6.0 0.13 11.5 3.4 1.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2347) BAR PF03114.13 ESA02801.1 - 0.15 11.5 9.7 0.48 9.8 6.7 1.6 1 1 1 2 2 2 0 BAR domain ABC_tran_2 PF12848.2 ESA02801.1 - 0.37 10.6 5.9 0.93 9.3 4.1 1.7 1 0 0 1 1 1 0 ABC transporter DUF2935 PF11155.3 ESA02801.1 - 0.42 10.7 7.3 3.4 7.7 2.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) TMPIT PF07851.8 ESA02801.1 - 0.72 8.8 8.3 0.59 9.1 2.8 2.0 1 1 1 2 2 2 0 TMPIT-like protein OmpH PF03938.9 ESA02801.1 - 1 9.2 7.6 4.6 7.1 5.3 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) IncA PF04156.9 ESA02801.1 - 1.5 8.4 5.3 3.5 7.1 3.6 1.8 1 1 0 1 1 1 0 IncA protein Elongin_A PF06881.6 ESA02801.1 - 2.8 8.3 8.4 3.9 7.9 5.5 1.5 1 1 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Syntaxin_2 PF14523.1 ESA02801.1 - 3.6 7.6 10.1 0.52 10.3 0.1 2.8 1 1 1 3 3 3 0 Syntaxin-like protein Sod_Fe_N PF00081.17 ESA02801.1 - 4.6 7.5 6.4 7.4 6.9 0.4 2.8 1 1 2 3 3 3 0 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF3997 PF13162.1 ESA02802.1 - 0.014 15.1 0.0 0.018 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3997) W_rich_C PF07483.6 ESA02802.1 - 0.055 13.1 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain Pkinase PF00069.20 ESA02803.1 - 4.6e-44 150.5 0.0 5.9e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02803.1 - 3.7e-39 134.3 0.0 4.7e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA02803.1 - 0.0066 15.5 0.0 0.0097 14.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA02803.1 - 0.0086 15.0 0.0 0.088 11.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA02803.1 - 0.0091 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA02803.1 - 0.017 14.4 0.2 0.054 12.8 0.0 1.9 1 1 0 2 2 2 0 RIO1 family WaaY PF06176.6 ESA02803.1 - 0.031 13.5 0.3 0.054 12.6 0.2 1.4 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) p450 PF00067.17 ESA02804.1 - 0.00014 20.5 0.0 0.00015 20.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rad4 PF03835.10 ESA02807.1 - 1.1e-34 118.9 2.4 3.7e-34 117.1 1.7 2.0 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 ESA02807.1 - 2.7e-27 94.2 0.2 5.9e-27 93.1 0.2 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 ESA02807.1 - 1.6e-19 69.1 0.3 3.6e-19 68.0 0.2 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 ESA02807.1 - 1.3e-16 60.6 0.4 5.8e-16 58.5 0.1 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 ESA02807.1 - 6.5e-06 26.3 0.4 7.6e-05 22.8 0.3 2.6 1 1 0 1 1 1 1 Transglutaminase-like superfamily Papo_T_antigen PF02380.10 ESA02807.1 - 0.054 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 T-antigen specific domain Fumerase PF05681.9 ESA02807.1 - 0.098 11.7 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) ArgK PF03308.11 ESA02807.1 - 0.16 10.7 0.0 0.33 9.6 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Arf PF00025.16 ESA02808.1 - 1.1e-70 236.3 0.5 1.3e-70 236.1 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESA02808.1 - 2.2e-12 46.4 1.9 1.2e-07 30.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESA02808.1 - 2.2e-11 43.3 0.0 2.8e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 ESA02808.1 - 9.4e-09 35.2 0.1 1.9e-08 34.2 0.0 1.5 1 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 ESA02808.1 - 2.4e-08 34.5 0.0 3.2e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 ESA02808.1 - 2.7e-08 33.3 0.0 3.1e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 ESA02808.1 - 1.4e-06 27.6 0.0 1.7e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA02808.1 - 5.5e-06 25.9 0.0 0.0004 19.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.14 ESA02808.1 - 0.012 15.0 0.0 0.24 10.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 ESA02808.1 - 0.016 15.5 0.2 0.038 14.3 0.1 1.6 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA02808.1 - 0.044 13.2 0.0 0.096 12.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 ESA02808.1 - 0.05 12.8 0.2 0.19 11.0 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Arch_ATPase PF01637.13 ESA02808.1 - 0.052 13.2 0.1 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase DUF3010 PF11215.3 ESA02809.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3010) MreB_Mbl PF06723.8 ESA02810.1 - 0.00029 19.5 0.1 0.078 11.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA02810.1 - 0.00051 18.0 0.6 0.77 7.5 0.3 2.8 2 1 0 2 2 2 2 Hsp70 protein StbA PF06406.6 ESA02810.1 - 0.056 12.3 0.0 2.4 7.0 0.0 2.2 2 0 0 2 2 2 0 StbA protein tRNA-synt_1 PF00133.17 ESA02810.1 - 0.12 10.2 0.0 0.2 9.5 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) MAGUK_N_PEST PF10608.4 ESA02811.1 - 0.086 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK Luciferase_N PF05295.6 ESA02811.1 - 0.093 12.5 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain UDPGT PF00201.13 ESA02814.1 - 8.3e-25 87.2 0.0 3.8e-24 85.1 0.0 1.8 1 1 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 ESA02814.1 - 6.9e-08 32.0 0.0 0.00041 19.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 ESA02814.1 - 1.7e-07 31.0 0.0 2.9e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.15 ESA02815.1 - 0.00055 19.7 0.0 0.00082 19.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_28 PF03033.15 ESA02816.1 - 0.00073 19.3 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_28 PF03033.15 ESA02817.1 - 0.00069 19.3 0.0 0.0009 19.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain TatD_DNase PF01026.16 ESA02818.1 - 1.3e-41 142.5 0.0 1.5e-41 142.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Microcephalin PF12258.3 ESA02818.1 - 0.17 10.8 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Microcephalin protein TP_methylase PF00590.15 ESA02819.1 - 3.8e-16 59.4 0.1 6.7e-16 58.6 0.0 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases MAGE PF01454.14 ESA02819.1 - 0.064 12.5 0.0 0.098 11.9 0.0 1.5 1 1 0 1 1 1 0 MAGE family Alg6_Alg8 PF03155.10 ESA02820.1 - 5.6e-145 483.7 36.7 8.4e-145 483.1 25.4 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF2029 PF09594.5 ESA02820.1 - 1.5 8.2 12.2 0.055 12.9 1.9 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2029) zf-C2H2 PF00096.21 ESA02822.1 - 2.2e-09 37.1 25.3 3.9e-05 23.7 1.7 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA02822.1 - 4.6e-08 32.8 21.4 0.00028 21.0 0.9 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA02822.1 - 1.9e-06 27.8 13.0 1.2e-05 25.3 0.2 2.7 3 0 0 3 3 2 2 Zinc-finger double domain IBR PF01485.16 ESA02822.1 - 0.059 13.2 4.0 0.085 12.7 2.8 1.4 1 1 0 1 1 1 0 IBR domain PHD_2 PF13831.1 ESA02822.1 - 0.12 11.6 0.1 0.12 11.6 0.0 2.4 3 0 0 3 3 3 0 PHD-finger zf-C2H2_6 PF13912.1 ESA02822.1 - 0.24 11.3 0.5 0.24 11.3 0.3 2.8 4 0 0 4 4 3 0 C2H2-type zinc finger zinc_ribbon_4 PF13717.1 ESA02822.1 - 0.32 10.7 0.1 0.32 10.7 0.1 2.7 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESA02822.1 - 0.38 10.3 0.1 0.38 10.3 0.1 2.7 3 0 0 3 3 3 0 zinc-ribbon domain RRN7 PF11781.3 ESA02822.1 - 0.63 9.5 0.2 0.63 9.5 0.1 2.2 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 FANCL_C PF11793.3 ESA02822.1 - 0.72 9.8 3.9 2 8.4 2.4 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Ogr_Delta PF04606.7 ESA02822.1 - 0.99 9.1 6.9 1.7 8.4 1.4 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger TFIIS_C PF01096.13 ESA02822.1 - 3.2 7.4 6.7 5.4 6.7 0.1 2.8 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-Di19 PF05605.7 ESA02822.1 - 3.7 7.7 9.3 0.59 10.2 3.6 1.8 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.5 ESA02822.1 - 4.7 7.2 8.7 2.5 8.1 0.8 2.9 3 0 0 3 3 3 0 Zinc ribbon domain zf-H2C2_5 PF13909.1 ESA02822.1 - 5.7 7.3 14.5 0.76 10.1 0.8 3.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain DUF629 PF04780.7 ESA02822.1 - 6.3 5.1 8.2 1.6 7.1 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2HC_2 PF13913.1 ESA02822.1 - 6.3 6.5 10.6 0.18 11.4 1.6 2.6 2 1 0 2 2 2 0 zinc-finger of a C2HC-type DEAD PF00270.24 ESA02823.1 - 2.6e-16 59.5 0.5 5.2e-16 58.6 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA02823.1 - 6.9e-07 29.0 0.0 5.1e-06 26.2 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.1 ESA02823.1 - 0.0027 16.8 0.2 0.0052 15.8 0.1 1.5 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DRTGG PF07085.7 ESA02823.1 - 0.059 12.9 0.1 2 8.0 0.0 3.0 3 1 0 3 3 3 0 DRTGG domain Myb_DNA-bind_6 PF13921.1 ESA02824.1 - 0.00023 21.2 2.0 0.00023 21.2 1.4 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA02824.1 - 0.00069 19.6 0.3 0.002 18.1 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain PEN-2 PF10251.4 ESA02825.1 - 7.6e-22 77.3 5.0 9.5e-22 77.0 3.5 1.1 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase PTPS PF01242.14 ESA02826.1 - 3.4e-35 120.3 0.2 3.9e-35 120.2 0.2 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase YolD PF08863.5 ESA02826.1 - 0.06 13.2 0.9 0.36 10.7 0.0 2.0 2 0 0 2 2 2 0 YolD-like protein DnaJ PF00226.26 ESA02828.1 - 9.3e-26 89.3 2.6 1.9e-25 88.3 1.8 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESA02828.1 - 2.7e-20 72.0 0.2 1.3e-16 60.2 0.0 2.7 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESA02828.1 - 7.1e-15 54.8 17.3 1.1e-14 54.1 12.0 1.3 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESA02828.1 - 0.033 13.8 10.2 0.51 10.0 1.4 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family A2L_zn_ribbon PF08792.5 ESA02828.1 - 1.9 8.0 21.4 1.7 8.1 0.3 4.3 3 1 1 4 4 4 0 A2L zinc ribbon domain Met_10 PF02475.11 ESA02829.1 - 1.3e-72 243.5 0.3 2.2e-72 242.8 0.2 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.5 ESA02829.1 - 0.0019 17.8 0.1 0.0053 16.3 0.0 1.9 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.8 ESA02829.1 - 0.0036 16.4 0.0 0.0087 15.2 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) EHN PF06441.7 ESA02829.1 - 0.0057 16.5 0.2 0.15 11.9 0.0 2.5 1 1 0 2 2 2 1 Epoxide hydrolase N terminus Methyltransf_18 PF12847.2 ESA02829.1 - 0.0079 16.7 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.10 ESA02829.1 - 0.0085 15.5 0.6 0.015 14.7 0.4 1.5 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_26 PF13659.1 ESA02829.1 - 0.062 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Helicase_C_2 PF13307.1 ESA02830.1 - 2.2e-55 187.1 0.1 7.1e-55 185.4 0.1 2.0 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 ESA02830.1 - 2.1e-52 177.0 5.5 5.2e-52 175.7 3.8 1.7 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 ESA02830.1 - 1.9e-05 24.2 0.1 0.035 13.6 0.1 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESA02830.1 - 0.0018 18.1 1.2 1.3 8.8 0.2 3.2 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.11 ESA02830.1 - 0.0099 15.1 0.0 5 6.3 0.0 2.7 2 0 0 2 2 2 2 PhoH-like protein RNA_polI_A14 PF08203.6 ESA02830.1 - 0.076 13.2 0.3 0.29 11.3 0.2 2.0 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 SNF2_N PF00176.18 ESA02830.1 - 0.079 11.7 5.7 0.2 10.4 3.9 1.8 1 1 0 1 1 1 0 SNF2 family N-terminal domain Histone_HNS PF00816.16 ESA02830.1 - 9.3 6.8 8.2 0.72 10.4 0.4 3.0 2 1 1 3 3 3 0 H-NS histone family Molybdopterin PF00384.17 ESA02831.1 - 1.9e-74 250.9 0.0 1.3e-73 248.1 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin oxidoreductase NADH-G_4Fe-4S_3 PF10588.4 ESA02831.1 - 3.7e-19 67.6 0.1 1e-18 66.2 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2_4 PF13510.1 ESA02831.1 - 2.5e-17 62.4 0.1 6e-17 61.2 0.1 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1982 PF09326.6 ESA02831.1 - 2.3e-13 50.0 0.0 5.9e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1982) Fer2 PF00111.22 ESA02831.1 - 2.4e-07 30.4 2.2 3.6e-07 29.8 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.22 ESA02831.1 - 0.1 12.2 1.0 3 7.6 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.2 ESA02831.1 - 0.15 12.0 2.4 0.23 11.4 0.6 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.6 ESA02831.1 - 0.47 10.3 4.3 2.7 7.9 1.7 2.9 2 1 0 2 2 2 0 Divergent 4Fe-4S mono-cluster DUF553 PF04473.7 ESA02840.1 - 0.069 12.4 0.1 0.64 9.2 0.0 2.2 1 1 1 2 2 2 0 Transglutaminase-like domain DUF553 PF04473.7 ESA02841.1 - 0.046 12.9 0.1 0.11 11.7 0.0 1.6 1 1 0 1 1 1 0 Transglutaminase-like domain Glyco_transf_28 PF03033.15 ESA02843.1 - 0.00019 21.1 0.0 0.00029 20.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_4 PF13439.1 ESA02843.1 - 0.03 14.0 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_transf_28 PF03033.15 ESA02844.1 - 3.3e-05 23.6 0.0 4.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 ESA02845.1 - 3.9e-33 114.7 0.0 5.6e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA02845.1 - 1.3e-09 37.8 0.1 1.9e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA02845.1 - 2.1e-06 27.1 0.0 4.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 1 Pico_P2B PF01552.12 ESA02845.1 - 0.13 12.4 0.3 1.1 9.4 0.0 2.5 3 0 0 3 3 3 0 Picornavirus 2B protein BTB PF00651.26 ESA02846.1 - 3.9e-17 62.2 0.0 9.1e-17 61.0 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA02846.1 - 6.5e-08 32.6 0.0 1.5e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02846.1 - 2.1e-07 30.7 0.5 0.00093 19.0 0.1 2.6 2 0 0 2 2 2 2 BTB And C-terminal Kelch ECH PF00378.15 ESA02847.1 - 3.9e-82 275.0 0.1 4.4e-82 274.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 ESA02847.1 - 0.00011 22.0 0.0 0.062 13.0 0.0 2.3 2 0 0 2 2 2 2 Peptidase family S49 ECH_C PF13766.1 ESA02847.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 2-enoyl-CoA Hydratase C-terminal region UDPGT PF00201.13 ESA02848.1 - 4.1e-28 98.1 0.0 5.8e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA02848.1 - 1.5e-08 34.4 0.0 2.1e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA02848.1 - 4.6e-05 22.7 0.0 8.2e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 1 CAP_GLY PF01302.20 ESA02850.1 - 2e-19 69.0 0.1 3.8e-19 68.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 ESA02850.1 - 5.3e-15 54.6 35.2 0.00012 21.5 0.2 6.9 4 1 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA02850.1 - 2.6e-10 39.9 18.7 0.0025 17.5 0.7 4.8 2 1 2 4 4 4 4 Leucine rich repeat LRR_9 PF14580.1 ESA02850.1 - 2.8e-06 26.9 1.0 0.00017 21.2 0.1 2.3 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.1 ESA02850.1 - 2.7e-05 23.7 15.9 2.1 8.6 0.0 7.9 8 0 0 8 8 8 2 Leucine Rich repeat LRR_7 PF13504.1 ESA02850.1 - 0.0011 18.7 6.5 67 4.3 0.0 7.1 7 0 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 ESA02850.1 - 4 7.8 27.6 1.5 9.1 0.1 7.4 5 3 2 7 7 7 0 Leucine Rich Repeat Syja_N PF02383.13 ESA02852.1 - 6.3e-94 314.3 1.4 9.1e-94 313.7 0.9 1.2 1 0 0 1 1 1 1 SacI homology domain zf-HIT PF04438.11 ESA02853.1 - 7.5e-06 25.4 15.8 7.5e-06 25.4 10.9 2.1 1 1 1 2 2 2 1 HIT zinc finger DSX_dimer PF08828.5 ESA02853.1 - 0.038 13.5 0.2 0.092 12.3 0.1 1.6 1 0 0 1 1 1 0 Doublesex dimerisation domain PSI_PsaH PF03244.9 ESA02853.1 - 0.06 12.5 0.1 0.086 12.0 0.1 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI PolC_DP2 PF03833.8 ESA02853.1 - 0.11 10.1 3.0 0.1 10.2 2.1 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Pkinase_Tyr PF07714.12 ESA02854.1 - 9.3e-22 77.3 0.0 1.1e-21 77.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02854.1 - 5.6e-20 71.5 0.4 1.1e-19 70.6 0.3 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF4512 PF14975.1 ESA02855.1 - 0.094 13.5 1.9 0.14 13.0 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) YgbB PF02542.11 ESA02855.1 - 0.16 11.7 0.5 0.17 11.6 0.3 1.1 1 0 0 1 1 1 0 YgbB family DUF1441 PF07278.6 ESA02855.1 - 0.24 11.0 2.8 0.31 10.6 1.3 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1441) Pkinase PF00069.20 ESA02856.1 - 1.5e-29 102.9 0.2 2e-29 102.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02856.1 - 1e-27 96.8 0.0 1.5e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RicinB_lectin_2 PF14200.1 ESA02857.1 - 0.054 13.8 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like YycC PF14174.1 ESA02857.1 - 0.064 12.9 0.5 42 3.9 0.0 3.4 3 0 0 3 3 3 0 YycC-like protein Ins145_P3_rec PF08709.6 ESA02858.1 - 0.00031 19.8 0.1 0.017 14.1 0.0 2.2 1 1 1 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA02858.1 - 0.019 14.4 0.0 0.074 12.5 0.0 2.2 1 1 0 1 1 1 0 MIR domain TRCF PF03461.10 ESA02858.1 - 0.053 13.4 0.0 1.8 8.5 0.0 2.6 2 1 1 3 3 3 0 TRCF domain MIR PF02815.14 ESA02859.1 - 0.022 14.2 0.0 0.066 12.7 0.0 1.8 1 1 0 1 1 1 0 MIR domain GSH_synth_ATP PF03917.12 ESA02860.1 - 5.7e-56 189.6 0.0 7.3e-56 189.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain G-gamma PF00631.17 ESA02863.1 - 5.1e-17 61.3 0.0 5.8e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 GGL domain ELFV_dehydrog PF00208.16 ESA02864.1 - 8.5e-53 179.4 1.0 2.2e-50 171.5 0.0 2.3 1 1 1 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 ESA02864.1 - 3.6e-47 159.2 0.0 5.7e-47 158.5 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.14 ESA02864.1 - 0.0059 15.7 0.1 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 ESA02864.1 - 0.023 14.5 0.1 0.049 13.4 0.1 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.1 ESA02864.1 - 0.024 14.9 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding F-box-like PF12937.2 ESA02865.1 - 0.0033 17.1 1.5 0.0033 17.1 1.0 2.3 2 0 0 2 2 2 1 F-box-like DUF624 PF04854.9 ESA02866.1 - 0.32 10.8 1.3 5.7 6.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF624 PB1 PF00564.19 ESA02867.1 - 0.1 12.2 0.5 0.19 11.3 0.4 1.5 1 0 0 1 1 1 0 PB1 domain His_Phos_1 PF00300.17 ESA02868.1 - 5.8e-09 36.2 0.0 0.00018 21.6 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Xpo1 PF08389.7 ESA02869.1 - 2.9e-25 88.9 3.2 2.2e-24 86.0 0.3 3.2 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.14 ESA02869.1 - 9.2e-05 22.2 0.8 0.025 14.5 0.3 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_EZ PF13513.1 ESA02869.1 - 0.0013 19.1 0.1 8.4 7.0 0.0 4.7 3 0 0 3 3 3 1 HEAT-like repeat zf-DHHC PF01529.15 ESA02870.1 - 5.9e-34 116.9 12.6 5.9e-34 116.9 8.7 2.8 1 1 1 2 2 2 1 DHHC palmitoyltransferase DUF3333 PF11812.3 ESA02870.1 - 0.059 13.3 0.1 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) UQ_con PF00179.21 ESA02871.1 - 3.1e-47 159.5 0.0 3.5e-47 159.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA02871.1 - 5.4e-05 22.9 0.0 6.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA02871.1 - 0.011 15.6 0.1 0.015 15.1 0.0 1.6 1 1 0 1 1 1 0 RWD domain Pkip-1 PF06878.6 ESA02871.1 - 0.051 13.4 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 Pkip-1 protein Glyco_transf_28 PF03033.15 ESA02872.1 - 0.00024 20.8 0.0 0.00037 20.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_transf_28 PF03033.15 ESA02873.1 - 1.6e-05 24.7 0.0 2.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.13 ESA02874.1 - 4.6e-30 104.6 0.0 6.5e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA02874.1 - 1.9e-10 40.6 0.0 6.2e-10 38.9 0.0 1.7 1 1 1 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA02874.1 - 4.3e-07 29.4 0.0 6.9e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 1 DUF3635 PF12330.3 ESA02876.1 - 0.028 14.4 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3635) RNA_pol_L_2 PF13656.1 ESA02876.1 - 0.031 13.7 0.2 0.11 11.9 0.0 2.0 3 0 0 3 3 3 0 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-C2H2_4 PF13894.1 ESA02877.1 - 0.00019 21.5 0.3 0.00043 20.4 0.2 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.7 ESA02877.1 - 0.00047 20.2 0.9 0.0038 17.3 0.5 2.1 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESA02877.1 - 0.0025 18.0 0.1 0.0063 16.8 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type Metalloenzyme PF01676.13 ESA02879.1 - 2e-83 279.6 0.0 2.3e-83 279.4 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.8 ESA02879.1 - 5.1e-73 245.1 0.0 6.9e-73 244.6 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.17 ESA02879.1 - 4.8e-08 32.7 0.0 1.8e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 ESA02879.1 - 0.00035 19.8 0.0 0.002 17.3 0.0 2.3 2 1 0 2 2 2 1 Sulfatase DUF2292 PF10055.4 ESA02879.1 - 0.094 12.0 0.0 0.23 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2292) DEAD PF00270.24 ESA02880.1 - 8.6e-23 80.6 0.2 9e-22 77.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA02880.1 - 2e-11 43.5 0.0 7e-11 41.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OapA PF04225.7 ESA02880.1 - 0.11 12.4 0.2 28 4.6 0.0 3.2 4 0 0 4 4 4 0 Opacity-associated protein A LysM-like domain Sel1 PF08238.7 ESA02881.1 - 2.5e-38 129.6 24.0 3.9e-08 33.6 1.8 7.3 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.1 ESA02881.1 - 8.5e-05 22.7 4.6 0.046 14.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF1730 PF08331.5 ESA02881.1 - 0.053 13.2 0.6 0.13 11.9 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1730) TPR_11 PF13414.1 ESA02881.1 - 4 7.1 14.6 2.2 7.9 1.0 3.8 3 3 1 4 4 4 0 TPR repeat Pkinase PF00069.20 ESA02882.1 - 2.8e-12 46.3 4.9 9.8e-12 44.5 3.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA02882.1 - 1.7e-06 27.2 1.8 1.1e-05 24.6 1.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA02882.1 - 0.00023 20.6 1.3 0.0004 19.7 0.1 2.1 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA02882.1 - 0.0016 18.2 0.1 0.0051 16.5 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA02882.1 - 0.077 12.0 0.5 0.14 11.2 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RecX PF02631.11 ESA02884.1 - 0.0033 17.6 0.1 3.5 7.8 0.1 2.8 2 0 0 2 2 2 2 RecX family Speriolin_N PF15058.1 ESA02884.1 - 0.048 13.5 0.6 0.094 12.6 0.4 1.5 1 0 0 1 1 1 0 Speriolin N terminus Arrestin_C PF02752.17 ESA02885.1 - 3.2e-11 43.4 2.2 9.7e-10 38.6 0.6 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ESA02885.1 - 8.4e-07 28.9 0.3 5.3e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.5 ESA02885.1 - 0.0015 17.6 1.9 0.19 10.8 0.2 2.1 2 0 0 2 2 2 2 Rgp1 DUF3883 PF13020.1 ESA02885.1 - 0.058 13.1 3.5 0.26 11.0 0.2 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF3883) LDB19 PF13002.2 ESA02885.1 - 0.075 12.5 0.0 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Arrestin_N terminal like DUF2256 PF10013.4 ESA02887.1 - 0.24 11.1 1.9 3 7.6 0.6 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Peptidase_S24 PF00717.18 ESA02889.1 - 3.3e-05 23.4 0.4 7.3e-05 22.3 0.1 1.7 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.4 ESA02889.1 - 0.0055 16.2 0.0 0.12 11.9 0.0 2.2 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 CALCOCO1 PF07888.6 ESA02891.1 - 3.2e-05 22.4 6.0 4e-05 22.1 4.2 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF869 PF05911.6 ESA02891.1 - 0.011 14.0 2.9 0.014 13.7 2.0 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) GAS PF13851.1 ESA02891.1 - 0.027 13.6 8.1 0.035 13.2 5.6 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Phlebovirus_NSM PF07246.6 ESA02891.1 - 0.06 12.4 0.8 0.072 12.2 0.6 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF1664 PF07889.7 ESA02891.1 - 0.16 11.7 2.2 0.23 11.2 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ERM PF00769.14 ESA02891.1 - 0.29 10.6 7.5 1.8 8.0 5.4 1.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family CASP_C PF08172.7 ESA02891.1 - 0.46 9.4 9.1 1.4 7.9 1.4 2.1 1 1 1 2 2 2 0 CASP C terminal BRE1 PF08647.6 ESA02891.1 - 0.8 9.7 7.4 0.62 10.0 0.3 2.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase IncA PF04156.9 ESA02891.1 - 1.1 8.8 9.3 1.6 8.3 6.4 1.1 1 0 0 1 1 1 0 IncA protein Spc24 PF08286.6 ESA02891.1 - 1.9 8.1 7.0 5.8 6.6 1.8 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.15 ESA02891.1 - 2 8.2 9.3 2.9 7.6 0.2 2.2 1 1 1 2 2 2 0 Prefoldin subunit Cep57_CLD_2 PF14197.1 ESA02891.1 - 8.2 6.4 10.5 16 5.5 7.2 1.5 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 ATP_bind_4 PF01902.12 ESA02892.1 - 1.3e-43 148.9 0.0 4.1e-43 147.2 0.0 1.8 1 1 0 1 1 1 1 ATP-binding region Dimer_Tnp_hAT PF05699.9 ESA02893.1 - 0.022 14.3 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region BAH PF01426.13 ESA02895.1 - 0.0004 20.1 1.7 0.00094 18.9 0.1 2.2 2 0 0 2 2 2 1 BAH domain DUF2098 PF09871.4 ESA02895.1 - 0.44 10.5 2.8 21 5.1 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) BTB PF00651.26 ESA02896.1 - 3.3e-13 49.5 0.1 1.6e-12 47.3 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA02896.1 - 8.5e-13 48.4 0.2 1.9e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA02896.1 - 8.5e-07 28.7 2.0 2.9e-05 23.8 0.3 3.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA02896.1 - 0.039 13.0 0.1 0.091 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF4309 PF14172.1 ESA02899.1 - 0.034 14.1 0.7 0.04 13.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4309) MatP PF06303.7 ESA02901.1 - 0.035 14.0 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 Organiser of macrodomain of Terminus of chromosome TEBP_beta PF07404.6 ESA02901.1 - 0.065 12.3 0.3 0.079 12.0 0.2 1.1 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Sel1 PF08238.7 ESA02902.1 - 1.3e-51 171.9 5.1 1.4e-09 38.2 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_11 PF13414.1 ESA02902.1 - 7.3e-05 22.3 15.5 0.39 10.3 2.2 4.9 3 1 4 7 7 7 3 TPR repeat PG_binding_2 PF08823.6 ESA02902.1 - 0.0043 17.1 0.8 0.1 12.7 0.1 2.4 2 0 0 2 2 2 1 Putative peptidoglycan binding domain MIT PF04212.13 ESA02902.1 - 0.0059 16.4 14.6 0.56 10.1 1.3 4.6 2 1 3 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA02902.1 - 0.023 15.1 6.7 5.8 7.5 0.1 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF2666 PF10869.3 ESA02902.1 - 0.044 13.8 4.1 0.13 12.2 2.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) TPR_17 PF13431.1 ESA02902.1 - 0.58 10.5 10.8 8.8 6.8 0.0 5.3 4 2 0 5 5 5 0 Tetratricopeptide repeat FtsK_SpoIIIE PF01580.13 ESA02904.1 - 0.037 13.5 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Pox_A32 PF04665.7 ESA02905.1 - 3.6e-06 26.4 0.0 0.00028 20.2 0.0 2.3 2 0 0 2 2 2 2 Poxvirus A32 protein DUF2726 PF10881.3 ESA02905.1 - 0.041 13.4 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) Zot PF05707.7 ESA02905.1 - 0.1 12.0 0.0 3.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Exo_endo_phos PF03372.18 ESA02906.1 - 1.2e-14 54.8 0.9 1.9e-14 54.2 0.6 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA02906.1 - 8.7e-13 47.9 7.7 8.7e-13 47.9 5.3 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Dimer_Tnp_hAT PF05699.9 ESA02907.1 - 0.0031 17.0 0.0 0.0091 15.5 0.0 1.8 1 1 1 2 2 2 1 hAT family C-terminal dimerisation region Gemini_AC4_5 PF04807.7 ESA02907.1 - 0.038 13.4 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region DUF3085 PF11284.3 ESA02907.1 - 0.24 11.6 1.5 1.5 9.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3085) Glyco_transf_11 PF01531.11 ESA02911.1 - 0.04 12.9 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 11 Sec62 PF03839.11 ESA02911.1 - 7.8 5.8 15.4 11 5.3 10.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 LacAB_rpiB PF02502.13 ESA02914.1 - 1.4e-14 53.9 0.1 1.9e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Cupin_2 PF07883.6 ESA02914.1 - 3.2e-05 23.3 2.8 5.3e-05 22.6 1.9 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_8 PF13621.1 ESA02914.1 - 0.06 12.8 1.5 0.13 11.7 0.4 1.6 1 1 1 2 2 2 0 Cupin-like domain Ectoine_synth PF06339.7 ESA02914.1 - 0.082 12.8 0.3 0.097 12.5 0.2 1.2 1 0 0 1 1 1 0 Ectoine synthase Cupin_4 PF08007.7 ESA02914.1 - 0.1 11.8 0.4 2.9 7.0 0.0 2.0 1 1 1 2 2 2 0 Cupin superfamily protein Kelch_4 PF13418.1 ESA02915.1 - 3e-23 81.3 14.9 1e-06 28.3 0.0 6.5 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA02915.1 - 9.2e-22 76.6 6.1 8.2e-06 25.8 0.1 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA02915.1 - 5.4e-17 61.3 1.3 0.0054 16.6 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESA02915.1 - 1.8e-09 36.9 9.0 0.098 12.2 0.1 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESA02915.1 - 3.1e-09 36.6 9.1 0.018 15.1 0.0 6.0 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA02915.1 - 2.6e-06 26.9 5.3 0.028 14.1 0.0 5.4 6 2 0 6 6 6 2 Kelch motif YajC PF02699.10 ESA02915.1 - 0.054 13.1 0.0 0.15 11.7 0.0 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit RCC1_2 PF13540.1 ESA02915.1 - 0.056 13.0 0.4 4.4 7.0 0.1 2.8 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat LVIVD PF08309.6 ESA02915.1 - 0.89 8.6 4.4 9.7 5.2 0.0 3.4 3 0 0 3 3 3 0 LVIVD repeat DUF4582 PF15189.1 ESA02916.1 - 0.028 13.6 0.5 0.033 13.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4582) DUF2452 PF10504.4 ESA02916.1 - 0.029 13.6 0.3 0.031 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) SWIM PF04434.12 ESA02917.1 - 0.046 13.2 0.1 0.071 12.6 0.1 1.3 1 0 0 1 1 1 0 SWIM zinc finger DUF3094 PF11293.3 ESA02917.1 - 0.33 10.4 1.3 0.46 9.9 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) Phage_integrase PF00589.17 ESA02920.1 - 7.3e-07 29.0 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family DUF3504 PF12012.3 ESA02920.1 - 0.00028 20.6 0.2 0.0014 18.4 0.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3504) DUF3436 PF11918.3 ESA02920.1 - 0.03 14.5 0.0 0.087 13.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3436) Lipase_3 PF01764.20 ESA02926.1 - 1.4e-13 50.6 0.0 2.5e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Spore_III_AF PF09581.5 ESA02926.1 - 0.1 12.4 2.6 0.15 11.8 0.2 2.2 3 0 0 3 3 3 0 Stage III sporulation protein AF (Spore_III_AF) V-SNARE_C PF12352.3 ESA02927.1 - 5.5e-16 58.3 0.6 5.5e-16 58.3 0.4 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 ESA02927.1 - 3.2e-06 26.7 2.9 1.2e-05 24.8 0.0 2.4 3 0 0 3 3 3 1 Sec20 Rad21_Rec8 PF04824.11 ESA02927.1 - 0.011 14.8 0.0 0.025 13.7 0.0 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein ATLF PF07737.6 ESA02927.1 - 0.023 14.1 3.5 1.8 7.9 0.0 2.4 2 1 1 3 3 3 0 Anthrax toxin lethal factor, N- and C-terminal domain TPR_MLP1_2 PF07926.7 ESA02927.1 - 2.2 8.0 10.8 7 6.4 7.4 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Ribosomal_S3_C PF00189.15 ESA02928.1 - 7.8e-16 58.0 0.1 1.6e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 ESA02928.1 - 1.3e-14 53.4 0.2 2.4e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.3 ESA02928.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Metallophos PF00149.23 ESA02929.1 - 2.2e-13 50.0 2.8 4.6e-13 49.0 2.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA02929.1 - 7.3e-09 35.6 0.0 1.2e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.1 ESA02929.1 - 0.05 12.7 0.0 0.092 11.8 0.0 1.4 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Sel1 PF08238.7 ESA02930.1 - 2.3e-31 107.5 22.8 2.7e-11 43.7 0.7 4.3 4 1 0 4 4 4 4 Sel1 repeat TPR_7 PF13176.1 ESA02930.1 - 0.15 11.9 0.6 0.89 9.5 0.1 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA02930.1 - 0.58 9.8 11.3 0.16 11.6 1.8 2.8 1 1 2 3 3 3 0 TPR repeat TPR_6 PF13174.1 ESA02930.1 - 0.84 10.2 8.6 4.4 7.9 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA02930.1 - 1 9.0 0.1 1 9.0 0.1 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat GST_C PF00043.20 ESA02931.1 - 6.3e-14 51.7 0.0 1.9e-13 50.2 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA02931.1 - 6e-13 48.8 0.0 9.9e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA02931.1 - 2.3e-12 46.8 0.0 4.4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA02931.1 - 9.1e-12 44.8 0.0 1.9e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA02931.1 - 4.2e-09 36.1 0.0 8.2e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA02931.1 - 5.5e-09 36.4 0.0 2.2e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain PARP PF00644.15 ESA02932.1 - 0.0011 18.4 0.1 0.0014 18.1 0.1 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Sel1 PF08238.7 ESA02933.1 - 4.8e-56 185.9 32.2 4.4e-11 43.0 1.2 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_16 PF13432.1 ESA02933.1 - 0.0051 17.4 1.9 6.7 7.5 0.0 3.9 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA02933.1 - 0.013 15.9 12.7 7.7 7.2 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA02933.1 - 0.43 10.2 24.1 0.98 9.1 0.5 4.1 2 2 1 3 3 3 0 TPR repeat PFO_beta_C PF12367.3 ESA02933.1 - 0.77 9.7 0.1 0.77 9.7 0.0 3.8 3 1 1 4 4 4 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal TPR_7 PF13176.1 ESA02933.1 - 3.3 7.7 5.0 3.4 7.6 0.1 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF4298 PF14131.1 ESA02933.1 - 4.3 7.2 12.2 0.42 10.5 1.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) AIG1 PF04548.11 ESA02934.1 - 1.3e-05 24.4 0.0 2.1e-05 23.7 0.0 1.3 1 1 0 1 1 1 1 AIG1 family DUF258 PF03193.11 ESA02934.1 - 5.1e-05 22.5 0.1 7.6e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 ESA02934.1 - 0.0018 18.1 0.1 0.0024 17.8 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase IstB_IS21 PF01695.12 ESA02934.1 - 0.0075 15.7 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Dynamin_N PF00350.18 ESA02934.1 - 0.06 13.1 0.1 0.24 11.2 0.0 1.8 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.1 ESA02934.1 - 0.087 12.9 0.1 0.11 12.6 0.1 1.4 1 1 0 1 1 1 0 AAA domain BTK PF00779.14 ESA02935.1 - 0.0078 15.8 4.0 0.0078 15.8 2.8 3.7 3 1 1 4 4 4 1 BTK motif PALP PF00291.20 ESA02936.1 - 2.9e-07 30.0 0.0 6.9e-07 28.7 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TPT PF03151.11 ESA02937.1 - 4.4e-14 52.4 31.8 5.5e-14 52.0 8.6 2.9 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 ESA02937.1 - 1.8e-08 34.4 36.4 2.5e-05 24.3 9.6 2.5 2 1 0 2 2 2 2 EamA-like transporter family Gelsolin PF00626.17 ESA02937.1 - 0.0052 16.4 0.3 0.016 14.8 0.1 1.8 2 0 0 2 2 2 1 Gelsolin repeat Atracotoxin PF05353.6 ESA02937.1 - 0.067 13.0 0.2 0.14 11.9 0.2 1.5 1 0 0 1 1 1 0 Delta Atracotoxin EmrE PF13536.1 ESA02937.1 - 3.5 7.8 28.8 0.91 9.7 4.5 3.2 2 1 1 3 3 3 0 Multidrug resistance efflux transporter UCH PF00443.24 ESA02938.1 - 1.9e-76 256.6 0.2 1.9e-76 256.6 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA02938.1 - 2.2e-27 96.2 0.0 4.7e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 ESA02938.1 - 0.0069 16.7 0.0 0.036 14.4 0.0 2.2 1 1 0 1 1 1 1 Rhodanese-like domain KH_1 PF00013.24 ESA02939.1 - 1.5e-05 24.5 1.9 2.3e-05 23.9 0.4 1.9 2 0 0 2 2 2 1 KH domain AP_endonuc_2 PF01261.19 ESA02939.1 - 0.0089 15.3 0.3 1.9 7.7 0.1 2.3 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel NUC153 PF08159.7 ESA02940.1 - 7.8e-07 28.5 0.4 2.2e-06 27.1 0.3 1.8 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.27 ESA02941.1 - 1.6e-28 97.5 17.7 3.7e-08 32.9 0.2 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ESA02941.1 - 0.0021 17.7 0.0 0.2 11.3 0.0 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A BBS2_N PF14781.1 ESA02941.1 - 0.027 14.1 0.1 7.1 6.2 0.0 2.8 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal PRCC PF10253.4 ESA02942.1 - 2e-20 74.2 5.5 2e-20 74.2 3.8 2.6 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting PCI PF01399.22 ESA02943.1 - 5e-19 68.5 0.3 4.8e-18 65.3 0.0 2.8 3 1 0 3 3 3 1 PCI domain Vps39_1 PF10366.4 ESA02943.1 - 0.028 14.4 0.3 0.16 11.9 0.3 2.2 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_7 PF13176.1 ESA02943.1 - 1.6 8.7 9.4 2.9 7.9 0.0 5.3 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA02943.1 - 1.7 8.6 17.4 4.5 7.2 0.2 5.1 5 2 0 5 5 5 0 Tetratricopeptide repeat Rax2 PF12768.2 ESA02944.1 - 4.5e-54 183.5 20.2 8.7e-47 159.6 0.1 7.1 5 3 1 7 7 7 6 Cortical protein marker for cell polarity PolyA_pol PF01743.15 ESA02945.1 - 2.5e-27 95.5 0.0 5.7e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 ESA02945.1 - 3.3e-06 26.5 0.0 7e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 ESA02945.1 - 0.00019 21.2 0.3 0.00075 19.3 0.2 1.9 1 1 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative WGG PF10273.4 ESA02946.1 - 1.9e-28 98.3 1.4 3.6e-28 97.4 1.0 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 CDC27 PF09507.5 ESA02946.1 - 0.0095 15.2 5.1 0.0099 15.1 3.6 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 HlyU PF10115.4 ESA02946.1 - 0.044 13.6 0.7 3.1 7.6 0.1 2.2 2 0 0 2 2 2 0 Transcriptional activator HlyU RXT2_N PF08595.6 ESA02946.1 - 0.18 11.5 6.6 0.28 10.9 4.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.1 ESA02946.1 - 1.4 8.6 4.9 2.2 7.9 3.4 1.3 1 0 0 1 1 1 0 FAM176 family UPF0449 PF15136.1 ESA02947.1 - 0.0065 16.6 0.0 0.42 10.8 0.0 2.1 1 1 0 1 1 1 1 Uncharacterised protein family UPF0449 MRP-L47 PF06984.8 ESA02949.1 - 0.007 16.2 0.0 0.0087 15.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) TORC_M PF12885.2 ESA02949.1 - 0.069 12.9 1.7 0.076 12.7 0.5 1.4 1 1 0 1 1 1 0 Transducer of regulated CREB activity middle domain Cid2 PF09774.4 ESA02951.1 - 8.4e-23 81.1 4.4 2.2e-22 79.8 3.0 1.6 1 1 0 1 1 1 1 Caffeine-induced death protein 2 GatB_Yqey PF02637.13 ESA02951.1 - 0.04 13.6 0.3 0.059 13.0 0.2 1.2 1 0 0 1 1 1 0 GatB domain zf-U11-48K PF05253.7 ESA02952.1 - 2.6e-06 27.0 0.4 4.9e-06 26.1 0.3 1.5 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Phage_GPO PF05929.6 ESA02952.1 - 0.56 9.3 8.7 0.24 10.6 2.6 2.3 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.7 ESA02952.1 - 0.67 9.7 4.3 20 4.9 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.4 ESA02952.1 - 0.73 9.8 9.9 1.5 8.7 0.1 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein DUF3284 PF11687.3 ESA02952.1 - 1.5 8.5 8.2 1 9.0 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3284) Mnd1 PF03962.10 ESA02952.1 - 5.9 6.5 18.6 0.83 9.2 6.9 2.3 2 1 0 2 2 2 0 Mnd1 family MreB_Mbl PF06723.8 ESA02953.1 - 0.00029 19.5 0.0 0.0081 14.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Enolase_C PF00113.17 ESA02955.1 - 1.5e-161 536.2 0.1 2e-161 535.8 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 ESA02955.1 - 9.2e-59 197.1 0.2 1.5e-58 196.4 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 ESA02955.1 - 0.0092 15.9 0.0 0.025 14.5 0.0 1.8 2 0 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.6 ESA02955.1 - 0.01 14.7 0.5 0.029 13.3 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus FYVE PF01363.16 ESA02956.1 - 1.1e-27 95.6 32.0 3.1e-19 68.6 5.8 3.1 3 0 0 3 3 3 2 FYVE zinc finger FYVE_2 PF02318.11 ESA02956.1 - 0.0017 18.2 7.5 0.0017 18.2 5.2 4.2 4 1 0 4 4 4 1 FYVE-type zinc finger DUF4428 PF14471.1 ESA02956.1 - 0.56 10.0 10.0 0.48 10.2 1.9 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) TB2_DP1_HVA22 PF03134.14 ESA02957.1 - 5.2e-35 119.0 7.9 7.4e-35 118.5 5.5 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Asp_protease_2 PF13650.1 ESA02958.1 - 0.0027 18.1 0.1 0.0044 17.4 0.0 1.5 1 1 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA02958.1 - 0.0098 15.7 0.3 0.023 14.5 0.2 1.9 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp PF00026.18 ESA02958.1 - 0.11 11.7 0.0 0.21 10.7 0.0 1.3 1 1 0 1 1 1 0 Eukaryotic aspartyl protease LRR_4 PF12799.2 ESA02960.1 - 2e-08 33.6 1.9 5e-06 26.0 0.9 2.5 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA02960.1 - 3.3e-08 32.7 6.6 0.028 14.4 0.1 4.3 4 0 0 4 4 4 3 Leucine Rich repeat LRR_8 PF13855.1 ESA02960.1 - 2.6e-07 30.3 5.4 0.00027 20.6 0.1 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 ESA02960.1 - 2.2e-05 23.8 9.8 0.53 10.5 0.1 4.2 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_7 PF13504.1 ESA02960.1 - 0.00043 20.0 3.9 2.9 8.4 0.1 4.0 4 0 0 4 4 4 2 Leucine rich repeat PDE8 PF08629.5 ESA02960.1 - 0.058 13.2 0.3 0.095 12.5 0.2 1.3 1 0 0 1 1 1 0 PDE8 phosphodiesterase LRR_2 PF07723.8 ESA02960.1 - 6.2 7.4 10.0 0.96 10.0 2.3 2.8 3 0 0 3 3 3 0 Leucine Rich Repeat Laminin_G_3 PF13385.1 ESA02961.1 - 3e-16 60.0 0.0 3.8e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.12 ESA02961.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Pentaxin family MIR PF02815.14 ESA02962.1 - 7.1e-08 32.2 0.2 0.00021 20.9 0.0 3.2 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA02962.1 - 0.026 13.5 0.0 0.09 11.7 0.0 1.8 1 1 1 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Pkinase_Tyr PF07714.12 ESA02964.1 - 3.5e-29 101.6 0.0 5.9e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02964.1 - 3.8e-29 101.6 0.0 1.1e-28 100.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Eaf7 PF07904.8 ESA02965.1 - 0.057 13.3 12.1 0.45 10.5 4.3 2.1 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 DUF3804 PF12707.2 ESA02965.1 - 0.061 12.9 1.6 0.11 12.1 0.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3804) DUF2935 PF11155.3 ESA02966.1 - 0.036 14.1 5.4 0.05 13.6 2.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF972 PF06156.8 ESA02966.1 - 2.3 8.6 5.3 1.7 9.0 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Pkinase_Tyr PF07714.12 ESA02967.1 - 0.01 14.9 0.3 0.039 13.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase SUR7 PF06687.7 ESA02968.1 - 0.076 12.5 0.1 0.1 12.1 0.0 1.3 1 1 0 1 1 1 0 SUR7/PalI family Sel1 PF08238.7 ESA02969.1 - 2.2e-23 82.1 1.1 6.3e-14 52.0 0.5 2.2 2 0 0 2 2 2 2 Sel1 repeat GntP_permease PF02447.11 ESA02971.1 - 0.15 10.5 0.1 0.17 10.3 0.1 1.0 1 0 0 1 1 1 0 GntP family permease DnaJ_CXXCXGXG PF00684.14 ESA02971.1 - 0.46 10.5 20.2 9.5 6.3 14.0 2.4 1 1 0 1 1 1 0 DnaJ central domain Pkinase_Tyr PF07714.12 ESA02972.1 - 4.1e-38 130.9 0.2 1e-37 129.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA02972.1 - 9.9e-35 119.9 0.2 1.9e-34 118.9 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA02972.1 - 0.062 12.4 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA02972.1 - 0.29 10.8 0.5 0.53 9.9 0.4 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Trypan_PARP PF05887.6 ESA02973.1 - 0.12 12.2 6.1 0.13 12.0 4.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TRAP_alpha PF03896.11 ESA02973.1 - 0.14 11.1 1.5 0.14 11.1 1.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4637 PF15470.1 ESA02973.1 - 6.8 6.2 7.4 8.8 5.9 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) ABC_membrane PF00664.18 ESA02974.1 - 1.1e-114 382.5 35.5 1.5e-57 195.1 8.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA02974.1 - 1.9e-72 241.9 0.1 1.7e-38 132.0 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA02974.1 - 4.4e-15 55.5 7.5 4.3e-06 26.1 0.3 4.2 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 ESA02974.1 - 5.2e-10 38.5 5.2 0.00019 20.1 0.1 3.0 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_21 PF13304.1 ESA02974.1 - 5.7e-10 39.6 3.9 0.19 11.6 0.0 4.8 4 1 1 5 5 4 4 AAA domain AAA_17 PF13207.1 ESA02974.1 - 4.3e-08 34.0 0.0 0.012 16.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESA02974.1 - 4.3e-08 32.5 3.4 0.005 16.3 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 ESA02974.1 - 4e-07 30.2 3.1 0.018 15.0 0.2 3.3 2 2 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 ESA02974.1 - 8.3e-06 25.0 0.1 0.098 11.8 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SbcCD_C PF13558.1 ESA02974.1 - 9.4e-06 25.4 2.9 0.05 13.5 0.1 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 ESA02974.1 - 2.1e-05 24.6 3.5 0.16 12.1 0.1 3.7 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESA02974.1 - 0.0002 21.6 1.9 0.16 12.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 ESA02974.1 - 0.00076 18.9 0.8 3.4 7.0 0.0 3.9 5 0 0 5 5 5 2 AAA domain AAA_30 PF13604.1 ESA02974.1 - 0.0013 18.2 0.5 4.7 6.7 0.0 4.1 4 0 0 4 4 4 1 AAA domain DUF87 PF01935.12 ESA02974.1 - 0.0014 18.5 7.0 0.42 10.3 0.0 3.7 3 1 1 4 4 4 2 Domain of unknown function DUF87 AAA_19 PF13245.1 ESA02974.1 - 0.0021 17.7 0.6 2.5 7.8 0.0 3.5 3 0 0 3 3 3 1 Part of AAA domain AAA_5 PF07728.9 ESA02974.1 - 0.0032 17.2 0.1 4 7.1 0.0 3.6 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 ESA02974.1 - 0.0035 17.0 0.3 0.32 10.6 0.0 2.8 2 0 0 2 2 2 1 Adenylylsulphate kinase G-alpha PF00503.15 ESA02974.1 - 0.0052 15.5 0.7 1.5 7.4 0.6 2.7 2 1 0 2 2 2 1 G-protein alpha subunit Zeta_toxin PF06414.7 ESA02974.1 - 0.0065 15.5 0.8 4.4 6.3 0.0 3.4 3 0 0 3 3 3 1 Zeta toxin FtsK_SpoIIIE PF01580.13 ESA02974.1 - 0.0076 15.7 0.0 1.9 7.9 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family MobB PF03205.9 ESA02974.1 - 0.0084 15.8 1.8 4.1 7.1 0.1 3.2 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 ESA02974.1 - 0.0086 15.5 3.9 2.7 7.3 0.0 3.7 4 0 0 4 4 4 2 AAA-like domain AAA_28 PF13521.1 ESA02974.1 - 0.011 15.7 3.3 3.9 7.4 0.1 3.2 2 1 0 3 3 3 0 AAA domain AAA_33 PF13671.1 ESA02974.1 - 0.011 15.6 0.3 5.5 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.12 ESA02974.1 - 0.015 14.8 0.1 5.8 6.3 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_23 PF13476.1 ESA02974.1 - 0.017 15.4 7.8 3.2 8.0 0.0 3.5 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.18 ESA02974.1 - 0.066 13.1 1.1 16 5.5 0.0 3.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.7 ESA02974.1 - 0.53 9.9 2.3 17 5.0 0.1 2.6 2 0 0 2 2 2 0 NACHT domain F-box-like PF12937.2 ESA02975.1 - 0.00034 20.2 4.7 0.0004 20.0 1.7 2.3 2 0 0 2 2 2 1 F-box-like Peptidase_M1 PF01433.15 ESA02976.1 - 5.2e-84 282.5 0.0 7.2e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 ESA02976.1 - 5.4e-46 155.7 1.1 1.3e-45 154.5 0.3 2.0 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 ESA02976.1 - 1.2e-14 54.4 0.0 1.9e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 ESA02976.1 - 0.05 13.5 1.1 0.41 10.6 0.9 2.4 2 1 0 2 2 2 0 M61 glycyl aminopeptidase Nol1_Nop2_Fmu PF01189.12 ESA02977.1 - 9.8e-17 61.2 0.0 2e-16 60.2 0.0 1.4 1 1 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 ESA02977.1 - 0.0018 17.8 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA02977.1 - 0.0019 18.1 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Dimer_Tnp_hAT PF05699.9 ESA02978.1 - 9.6e-13 47.5 0.1 1e-12 47.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RNA_pol_L_2 PF13656.1 ESA02979.1 - 0.1 12.0 0.0 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain LRR_8 PF13855.1 ESA02981.1 - 0.023 14.4 3.6 3.4 7.4 0.0 3.5 2 1 2 4 4 4 0 Leucine rich repeat WEMBL PF05701.6 ESA02982.1 - 0.0014 17.1 0.1 0.0014 17.1 0.0 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DivIC PF04977.10 ESA02982.1 - 0.0032 16.9 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Septum formation initiator FlaC_arch PF05377.6 ESA02982.1 - 0.0072 16.1 0.6 0.016 15.0 0.4 1.6 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) DUF948 PF06103.6 ESA02982.1 - 0.0073 16.1 0.1 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 ESA02982.1 - 0.018 14.2 0.0 0.021 14.0 0.0 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein LPP PF04728.8 ESA02982.1 - 0.029 14.1 0.1 0.059 13.1 0.1 1.6 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF4618 PF15397.1 ESA02982.1 - 0.034 13.4 0.1 0.048 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) NPV_P10 PF05531.7 ESA02982.1 - 0.034 14.3 0.2 0.086 13.1 0.1 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.7 ESA02982.1 - 0.041 13.6 1.1 0.051 13.3 0.3 1.5 2 0 0 2 2 2 0 Laminin Domain II DUF3373 PF11853.3 ESA02982.1 - 0.056 11.9 0.0 0.067 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) EMP24_GP25L PF01105.19 ESA02982.1 - 0.068 12.8 0.2 0.089 12.4 0.1 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Fib_alpha PF08702.5 ESA02982.1 - 0.085 12.9 0.5 0.15 12.1 0.4 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Syntaxin PF00804.20 ESA02982.1 - 0.13 12.3 1.0 0.64 10.2 0.1 2.2 2 1 0 2 2 2 0 Syntaxin LRR_6 PF13516.1 ESA02983.1 - 0.00091 19.0 6.8 4.9 7.5 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.1 ESA02983.1 - 0.00092 18.9 1.0 0.72 9.6 0.2 3.1 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.2 ESA02983.1 - 0.081 12.5 1.3 2.7 7.7 0.2 3.1 1 1 2 4 4 4 0 Leucine Rich repeats (2 copies) gag-asp_proteas PF13975.1 ESA02984.1 - 0.00051 19.7 0.0 0.00076 19.2 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA02984.1 - 0.014 15.8 0.0 0.096 13.2 0.0 2.0 1 1 1 2 2 2 0 Aspartyl protease RVP_2 PF08284.6 ESA02984.1 - 0.09 12.7 0.0 0.43 10.5 0.0 1.8 1 1 1 2 2 2 0 Retroviral aspartyl protease Peptidase_A2B PF12384.3 ESA02984.1 - 0.095 12.0 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Ty3 transposon peptidase XPG_I PF00867.13 ESA02985.1 - 0.019 15.0 0.1 0.038 14.0 0.1 1.5 1 0 0 1 1 1 0 XPG I-region Acyl-thio_N PF12590.3 ESA02985.1 - 0.044 14.2 0.7 0.073 13.5 0.4 1.5 2 0 0 2 2 2 0 Acyl-ATP thioesterase DARPP-32 PF05395.7 ESA02985.1 - 0.12 12.4 3.4 0.19 11.8 2.3 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 KTSC PF13619.1 ESA02988.1 - 0.0062 16.1 0.0 0.019 14.6 0.0 1.8 1 0 0 1 1 1 1 KTSC domain DUF4441 PF14536.1 ESA02988.1 - 0.018 14.9 6.1 2.4 8.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) AAA_22 PF13401.1 ESA02988.1 - 0.037 14.1 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2781 PF10914.3 ESA02988.1 - 0.09 12.5 1.6 0.65 9.7 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) ASFV_J13L PF05568.6 ESA02988.1 - 0.24 10.9 3.1 0.44 10.0 2.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein YukC PF10140.4 ESA02989.1 - 0.0077 14.8 0.6 0.013 14.0 0.4 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Imm45 PF15603.1 ESA02989.1 - 0.029 14.5 0.9 1.1 9.4 0.1 2.3 2 0 0 2 2 2 0 Immunity protein 45 DUF1002 PF06207.6 ESA02989.1 - 1 8.6 8.6 1.3 8.2 5.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1002) Spc24 PF08286.6 ESA02990.1 - 0.014 15.0 10.5 0.017 14.8 7.3 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 APG6 PF04111.7 ESA02990.1 - 0.23 10.4 14.6 0.23 10.4 10.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 GH97_N PF14508.1 ESA02990.1 - 0.28 10.1 5.9 0.16 10.9 2.3 1.7 1 1 1 2 2 2 0 Glycosyl-hydrolase 97 N-terminal CEP19 PF14933.1 ESA02990.1 - 0.7 10.1 11.2 0.95 9.7 7.8 1.2 1 0 0 1 1 1 0 CEP19-like protein Cas_Csy4 PF09618.5 ESA02990.1 - 0.83 9.4 5.3 0.93 9.2 3.7 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) Cupredoxin_1 PF13473.1 ESA02990.1 - 0.86 9.5 3.5 10 6.0 0.0 2.0 1 1 1 2 2 2 0 Cupredoxin-like domain Z1 PF10593.4 ESA02990.1 - 0.88 8.7 8.5 0.98 8.5 5.9 1.0 1 0 0 1 1 1 0 Z1 domain Ax_dynein_light PF10211.4 ESA02990.1 - 0.96 9.2 15.5 1.2 8.9 10.8 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain V_ATPase_I PF01496.14 ESA02990.1 - 1.5 6.5 10.6 1.6 6.5 7.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.7 ESA02990.1 - 2 8.6 11.7 2.5 8.3 8.1 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF3450 PF11932.3 ESA02990.1 - 2.2 7.4 9.3 2.7 7.1 6.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF3332 PF11810.3 ESA02990.1 - 3.6 7.2 5.6 4.3 6.9 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Fib_alpha PF08702.5 ESA02990.1 - 3.6 7.7 9.6 4.5 7.3 6.6 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.1 ESA02990.1 - 4.3 6.2 6.9 4.7 6.0 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec62 PF03839.11 ESA02990.1 - 5.9 6.2 14.8 6.8 6.0 10.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Atg14 PF10186.4 ESA02990.1 - 6.1 5.6 13.1 6.7 5.5 9.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 ESA02990.1 - 8.1 5.9 11.2 9.8 5.7 7.8 1.2 1 0 0 1 1 1 0 IncA protein DUF724 PF05266.9 ESA02990.1 - 9.2 5.8 13.9 12 5.4 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1408 PF07193.6 ESA02991.1 - 0.15 11.5 0.2 0.29 10.6 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1408) HSDR_N_2 PF13588.1 ESA02992.1 - 0.025 14.3 0.0 0.11 12.3 0.0 2.1 2 1 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Zot PF05707.7 ESA02993.1 - 0.03 13.8 0.0 0.058 12.8 0.0 1.5 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) PRP1_N PF06424.7 ESA02998.1 - 4.6 7.5 8.0 13 6.0 5.5 1.8 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Fasciclin PF02469.17 ESA03000.1 - 0.007 16.3 5.6 0.11 12.5 0.6 2.5 2 0 0 2 2 2 2 Fasciclin domain RNaseH_C PF09293.5 ESA03000.1 - 0.23 11.3 4.0 5.6 6.9 0.1 2.7 1 1 0 2 2 2 0 T4 RNase H, C terminal F-box-like PF12937.2 ESA03001.1 - 0.00016 21.3 0.0 0.00076 19.1 0.0 2.3 2 0 0 2 2 2 1 F-box-like Sel1 PF08238.7 ESA03003.1 - 5.1e-63 208.1 35.6 4.5e-12 46.1 0.5 6.7 7 0 0 7 7 7 6 Sel1 repeat DUF3674 PF12426.3 ESA03003.1 - 0.00082 18.7 3.9 24 4.4 0.0 5.4 5 0 0 5 5 5 0 RNA dependent RNA polymerase TPR_20 PF14561.1 ESA03003.1 - 0.0022 18.0 1.2 9.7 6.3 0.0 3.9 2 2 2 4 4 4 1 Tetratricopeptide repeat DUF4041 PF13250.1 ESA03003.1 - 0.058 12.9 3.9 22 4.7 0.0 4.6 4 1 0 5 5 5 0 Domain of unknown function (DUF4041) MIT PF04212.13 ESA03003.1 - 0.08 12.8 22.6 0.42 10.5 2.3 5.1 4 2 0 4 4 4 0 MIT (microtubule interacting and transport) domain Proteasom_Rpn13 PF04683.8 ESA03003.1 - 0.15 12.1 8.5 48 4.1 0.0 5.3 6 0 0 6 6 6 0 Proteasome complex subunit Rpn13 ubiquitin receptor NUMOD1 PF07453.8 ESA03003.1 - 0.21 11.4 7.9 71 3.4 0.0 5.2 6 0 0 6 6 6 0 NUMOD1 domain DUF1389 PF07146.6 ESA03003.1 - 0.26 10.3 3.6 5.8 5.8 0.0 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1389) PNPase PF03726.9 ESA03003.1 - 0.66 10.2 3.0 1.7 8.9 0.1 2.8 3 2 1 4 4 4 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DCP1 PF06058.8 ESA03003.1 - 0.68 9.9 5.0 1.2 9.2 0.3 3.3 2 2 2 4 4 4 0 Dcp1-like decapping family LAGLIDADG_1 PF00961.14 ESA03003.1 - 1.3 9.5 7.0 3.5 8.2 0.2 2.5 2 1 0 2 2 2 0 LAGLIDADG endonuclease DUF3069 PF11269.3 ESA03004.1 - 0.0074 16.3 0.0 0.0092 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3069) DUF4364 PF14277.1 ESA03005.1 - 0.048 13.2 0.7 0.085 12.4 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) MFS_1 PF07690.11 ESA03006.1 - 1e-40 139.5 21.5 1e-40 139.5 14.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA03006.1 - 6.1e-10 38.2 9.1 6.1e-10 38.2 6.3 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.8 ESA03006.1 - 0.00015 20.0 0.8 0.00025 19.2 0.5 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector PRiA4_ORF3 PF07929.6 ESA03007.1 - 1.8e-54 183.9 0.7 2.5e-54 183.3 0.5 1.1 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein ABC2_membrane_4 PF12730.2 ESA03008.1 - 0.094 11.8 6.0 0.11 11.6 4.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Ninjurin PF04923.7 ESA03008.1 - 1.5 8.5 5.8 1.9 8.2 4.0 1.3 1 1 0 1 1 1 0 Ninjurin CBS PF00571.23 ESA03009.1 - 2.7e-24 84.6 7.8 1.7e-10 40.5 0.1 4.3 4 0 0 4 4 4 4 CBS domain Cys_Met_Meta_PP PF01053.15 ESA03010.1 - 9.8e-38 129.4 0.0 1.3e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 ESA03010.1 - 5.9e-05 22.1 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Kelch_3 PF13415.1 ESA03011.1 - 8.1e-06 25.8 4.7 0.029 14.5 0.7 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA03011.1 - 0.0014 18.7 3.9 0.33 11.2 0.3 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESA03011.1 - 0.0025 17.5 0.6 0.0025 17.5 0.4 3.1 2 1 0 2 2 2 1 Galactose oxidase, central domain Adeno_E3_CR2 PF02439.10 ESA03011.1 - 0.0031 17.0 1.5 0.0057 16.1 1.0 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Kelch_5 PF13854.1 ESA03011.1 - 0.0037 17.1 9.6 0.015 15.2 0.8 3.3 3 1 0 3 3 2 2 Kelch motif Mid2 PF04478.7 ESA03011.1 - 0.0068 15.8 1.0 0.011 15.0 0.6 1.4 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor Kelch_1 PF01344.20 ESA03011.1 - 0.013 15.0 5.9 0.07 12.6 0.4 3.1 3 0 0 3 3 3 0 Kelch motif Rax2 PF12768.2 ESA03011.1 - 0.015 14.4 0.0 0.14 11.3 0.0 1.9 2 0 0 2 2 2 0 Cortical protein marker for cell polarity EphA2_TM PF14575.1 ESA03011.1 - 0.018 15.3 0.2 0.033 14.5 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3827 PF12877.2 ESA03011.1 - 0.019 13.0 0.5 0.025 12.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Kelch_2 PF07646.10 ESA03011.1 - 0.031 14.0 0.8 0.62 9.9 0.1 2.8 3 0 0 3 3 3 0 Kelch motif Rab5ip PF07019.7 ESA03011.1 - 0.045 13.8 0.9 0.084 13.0 0.6 1.4 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) Syndecan PF01034.15 ESA03011.1 - 0.048 13.3 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 Syndecan domain DUF2569 PF10754.4 ESA03011.1 - 0.087 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Glycophorin_A PF01102.13 ESA03011.1 - 0.092 12.5 0.1 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A E1-E2_ATPase PF00122.15 ESA03012.1 - 3.4e-53 180.0 0.3 3.4e-53 180.0 0.2 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA03012.1 - 1e-41 142.4 9.6 1e-41 142.4 6.7 3.4 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA03012.1 - 7.8e-23 82.0 0.0 4.1e-22 79.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA03012.1 - 2.6e-17 62.5 0.1 5.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESA03012.1 - 3.1e-13 50.3 0.0 9.6e-13 48.7 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA03012.1 - 4.7e-06 25.9 0.6 3.4e-05 23.2 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESA03012.1 - 0.00074 19.1 2.1 0.088 12.3 0.0 3.1 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cyt_c_ox_IV PF12270.3 ESA03012.1 - 0.0053 16.4 0.1 0.029 14.1 0.0 2.3 2 0 0 2 2 2 1 Cytochrome c oxidase subunit IV Kelch_4 PF13418.1 ESA03013.1 - 4.9e-10 39.0 0.1 1e-06 28.4 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA03013.1 - 0.0038 17.3 0.3 3 8.1 0.1 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA03013.1 - 0.033 14.3 0.0 0.42 10.8 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.1 ESA03013.1 - 0.052 13.5 0.1 2 8.4 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.20 ESA03013.1 - 0.057 12.9 0.3 2.9 7.5 0.0 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.10 ESA03013.1 - 0.062 13.0 0.0 0.76 9.6 0.0 2.6 3 1 0 3 3 3 0 Kelch motif DUF3051 PF11252.3 ESA03013.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) TMF_DNA_bd PF12329.3 ESA03013.1 - 0.38 10.5 4.9 0.52 10.1 1.9 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Ammonium_transp PF00909.16 ESA03014.1 - 2.3e-119 398.4 27.0 2.7e-119 398.2 18.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family NinE PF05322.6 ESA03015.1 - 0.034 13.9 1.8 0.045 13.4 0.0 2.1 2 0 0 2 2 2 0 NINE Protein Cytochrome_C7 PF14522.1 ESA03015.1 - 0.11 12.1 2.5 0.082 12.5 0.4 1.7 2 0 0 2 2 2 0 Cytochrome c7 Evr1_Alr PF04777.8 ESA03015.1 - 0.18 11.7 1.0 3.4 7.6 0.7 2.5 1 1 0 1 1 1 0 Erv1 / Alr family zf-RING_5 PF14634.1 ESA03015.1 - 5.3 6.8 8.0 0.52 10.0 1.1 2.2 2 0 0 2 2 2 0 zinc-RING finger domain F-box-like PF12937.2 ESA03016.1 - 0.0046 16.6 1.0 0.0046 16.6 0.7 2.3 2 0 0 2 2 2 1 F-box-like Hydantoinase_A PF01968.13 ESA03018.1 - 0.039 13.0 0.0 0.055 12.5 0.0 1.5 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase PTE PF02126.13 ESA03018.1 - 0.051 12.5 0.2 0.11 11.4 0.2 1.5 1 1 0 1 1 1 0 Phosphotriesterase family HALZ PF02183.13 ESA03018.1 - 0.11 12.2 10.5 3.4 7.4 0.3 4.1 3 1 0 3 3 3 0 Homeobox associated leucine zipper THEG PF14912.1 ESA03018.1 - 0.11 13.0 3.5 0.18 12.3 0.6 2.3 2 0 0 2 2 2 0 Testicular haploid expressed repeat ADIP PF11559.3 ESA03018.1 - 0.32 10.8 16.8 0.037 13.9 6.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF904 PF06005.7 ESA03018.1 - 3.3 8.0 22.0 5.5 7.3 2.8 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF904) FlaC_arch PF05377.6 ESA03018.1 - 9.2 6.2 8.0 2.2 8.2 1.2 3.1 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Pkinase_Tyr PF07714.12 ESA03019.1 - 5.3e-96 320.6 0.1 3.6e-47 160.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA03019.1 - 9.2e-88 293.7 6.5 6.9e-44 149.9 0.2 3.1 3 0 0 3 3 3 2 Protein kinase domain APH PF01636.18 ESA03019.1 - 0.00061 19.5 4.7 0.33 10.6 0.3 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family UPF0122 PF04297.9 ESA03020.1 - 0.012 15.6 1.3 0.019 14.9 0.9 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like RRP7 PF12923.2 ESA03020.1 - 0.064 13.2 1.0 0.095 12.7 0.7 1.2 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) WbqC PF08889.6 ESA03020.1 - 0.085 12.3 0.3 0.12 11.8 0.2 1.1 1 0 0 1 1 1 0 WbqC-like protein family MerR_2 PF13591.1 ESA03020.1 - 0.16 11.5 0.9 0.61 9.7 0.3 2.0 2 0 0 2 2 2 0 MerR HTH family regulatory protein Snapin_Pallidin PF14712.1 ESA03020.1 - 0.88 9.9 4.7 1.5 9.1 3.3 1.3 1 0 0 1 1 1 0 Snapin/Pallidin Mob_synth_C PF06463.8 ESA03021.1 - 0.00056 19.6 0.5 1 9.0 0.0 2.3 2 0 0 2 2 2 2 Molybdenum Cofactor Synthesis C BCS1_N PF08740.6 ESA03021.1 - 0.0064 16.1 0.1 0.03 13.9 0.0 1.9 2 0 0 2 2 2 1 BCS1 N terminal DUF4047 PF13256.1 ESA03021.1 - 0.0084 16.0 2.1 1.2 9.0 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4047) DUF4411 PF14367.1 ESA03021.1 - 0.015 15.0 0.8 1.9 8.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4411) DUF4413 PF14372.1 ESA03021.1 - 0.025 14.5 0.3 7.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) DUF3548 PF12068.3 ESA03021.1 - 0.027 13.7 0.3 0.44 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3548) zf-ribbon_3 PF13248.1 ESA03021.1 - 0.03 13.5 1.6 0.28 10.4 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Bin3 PF06859.7 ESA03021.1 - 0.072 13.0 0.4 0.94 9.4 0.0 2.2 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) DZR PF12773.2 ESA03021.1 - 0.08 12.7 3.5 1.1 9.1 0.2 2.3 2 0 0 2 2 2 0 Double zinc ribbon Rpr2 PF04032.11 ESA03021.1 - 0.22 11.4 3.0 0.73 9.7 0.1 2.7 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ly49 PF08391.5 ESA03022.1 - 0.016 15.3 2.0 0.042 13.9 1.2 1.8 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Egg_lysin PF01303.12 ESA03022.1 - 0.047 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) zf-BED PF02892.10 ESA03024.1 - 1.7e-07 30.8 4.5 2.3e-07 30.4 3.1 1.2 1 0 0 1 1 1 1 BED zinc finger Lipase_2 PF01674.13 ESA03024.1 - 0.013 14.7 0.3 0.014 14.6 0.2 1.1 1 0 0 1 1 1 0 Lipase (class 2) zf-CCHC PF00098.18 ESA03024.1 - 0.098 12.6 0.4 5.4 7.1 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_4 PF13894.1 ESA03024.1 - 0.39 11.1 2.9 5.5 7.5 0.6 2.4 2 1 0 2 2 2 0 C2H2-type zinc finger Bromodomain PF00439.20 ESA03025.1 - 1.9e-17 62.9 0.5 2e-17 62.8 0.3 1.0 1 0 0 1 1 1 1 Bromodomain Pkinase PF00069.20 ESA03026.1 - 4.7e-33 114.4 0.1 1.2e-30 106.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03026.1 - 1.5e-32 112.6 0.0 6.5e-29 100.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase F-box-like PF12937.2 ESA03028.1 - 0.0023 17.5 1.2 0.0057 16.3 0.8 1.6 1 0 0 1 1 1 1 F-box-like DUF4557 PF15101.1 ESA03031.1 - 0.019 14.7 0.1 0.021 14.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) F-box-like PF12937.2 ESA03032.1 - 0.00011 21.8 1.9 0.00011 21.8 1.3 2.2 2 0 0 2 2 2 1 F-box-like BTB PF00651.26 ESA03033.1 - 5e-20 71.5 0.8 7.9e-20 70.9 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA03033.1 - 8e-06 25.6 3.1 0.00017 21.3 0.2 3.5 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA03033.1 - 0.028 13.5 0.4 0.037 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB_2 PF02214.17 ESA03033.1 - 0.11 12.6 0.6 0.61 10.3 0.0 2.3 2 1 1 3 3 3 0 BTB/POZ domain Ribosomal_L35Ae PF01247.13 ESA03035.1 - 0.091 12.5 0.3 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L35Ae Nitrate_red_gam PF02665.9 ESA03036.1 - 0.051 12.9 0.6 0.065 12.5 0.4 1.0 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Sel1 PF08238.7 ESA03041.1 - 1.6e-70 231.9 5.3 1.7e-08 34.8 0.7 8.2 8 0 0 8 8 8 8 Sel1 repeat Pkinase_Tyr PF07714.12 ESA03041.1 - 3.5e-19 68.9 0.0 5.1e-18 65.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03041.1 - 3.9e-11 42.5 0.1 3.9e-09 36.0 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain MIT PF04212.13 ESA03041.1 - 8.4e-05 22.3 12.7 0.36 10.7 0.0 5.8 5 2 0 5 5 5 2 MIT (microtubule interacting and transport) domain DUF3731 PF12531.3 ESA03041.1 - 0.03 13.8 0.0 19 4.6 0.0 3.3 4 0 0 4 4 4 0 DNA-K related protein TPR_11 PF13414.1 ESA03041.1 - 0.079 12.6 21.4 0.63 9.7 0.4 5.5 1 1 6 7 7 7 0 TPR repeat EF-hand_10 PF14788.1 ESA03041.1 - 0.86 9.3 7.0 25 4.6 0.0 5.1 8 0 0 8 8 8 0 EF hand CBM_X2 PF03442.9 ESA03042.1 - 0.033 14.0 0.4 0.042 13.6 0.3 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain X2 F-box-like PF12937.2 ESA03043.1 - 2.3e-07 30.4 2.0 5.3e-07 29.2 1.4 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA03043.1 - 0.28 10.9 25.0 1 9.2 1.5 4.8 3 2 2 5 5 5 0 Leucine rich repeat Pkinase_Tyr PF07714.12 ESA03044.1 - 3.1e-41 141.1 0.0 3.5e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03044.1 - 2.9e-39 134.7 0.0 3.3e-39 134.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA03044.1 - 0.00038 19.5 0.2 0.00053 19.1 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA03044.1 - 0.0076 15.6 0.4 0.012 14.9 0.3 1.3 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA03044.1 - 0.013 14.8 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL WaaY PF06176.6 ESA03044.1 - 0.018 14.2 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA03044.1 - 0.023 14.4 0.3 0.031 14.0 0.2 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family YjcQ PF09639.5 ESA03044.1 - 0.036 14.1 0.7 0.083 12.9 0.5 1.5 1 0 0 1 1 1 0 YjcQ protein HAT PF02184.11 ESA03045.1 - 0.073 12.8 0.1 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 HAT (Half-A-TPR) repeat VirB3 PF05101.8 ESA03048.1 - 0.13 12.2 0.3 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein MCM PF00493.18 ESA03049.1 - 5.1e-140 465.9 0.7 7.3e-140 465.4 0.5 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 ESA03049.1 - 3.2e-07 29.7 0.0 6.7e-05 22.1 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESA03049.1 - 6.5e-05 22.5 0.0 0.00084 18.9 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA03049.1 - 0.00012 21.8 0.0 0.00031 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 ESA03049.1 - 0.0017 18.6 0.5 0.005 17.1 0.1 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESA03049.1 - 0.007 15.8 0.0 0.42 10.0 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.24 ESA03049.1 - 0.063 13.4 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) adh_short PF00106.20 ESA03056.1 - 0.00045 20.1 0.0 0.00061 19.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase PRA1 PF03208.14 ESA03057.1 - 1e-25 89.8 0.2 1.2e-25 89.6 0.1 1.1 1 0 0 1 1 1 1 PRA1 family protein DUF4401 PF14351.1 ESA03057.1 - 0.037 13.0 0.7 0.045 12.7 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) Baculo_LEF-2 PF03041.9 ESA03058.1 - 0.11 12.1 0.1 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 lef-2 GILT PF03227.11 ESA03060.1 - 1e-08 34.9 2.7 1e-08 34.9 1.9 1.9 2 0 0 2 2 2 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Thioredoxin_4 PF13462.1 ESA03060.1 - 0.037 14.0 1.1 0.063 13.2 0.7 1.4 1 1 0 1 1 1 0 Thioredoxin DUF953 PF06110.6 ESA03060.1 - 0.051 13.0 0.5 0.25 10.7 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) MCM PF00493.18 ESA03061.1 - 3.7e-135 449.9 0.9 5.7e-135 449.3 0.2 1.5 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 ESA03061.1 - 7e-26 91.0 2.0 5.3e-25 88.2 0.5 3.1 2 1 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESA03061.1 - 1.3e-07 30.9 0.1 1.3e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESA03061.1 - 1.5e-07 31.2 0.0 2.7e-06 27.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 ESA03061.1 - 4.3e-05 23.8 2.4 0.00013 22.2 1.7 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESA03061.1 - 0.02 14.4 0.0 0.13 11.9 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Complex1_LYR PF05347.10 ESA03062.1 - 8.8e-10 38.2 0.0 1.8e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA03062.1 - 1.6e-07 31.4 0.0 3.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 ESA03062.1 - 8.8e-06 26.1 0.1 2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Nup88 PF10168.4 ESA03063.1 - 2.9e-23 81.6 10.3 8.1e-16 57.0 4.0 2.8 2 1 0 2 2 2 2 Nuclear pore component DUF489 PF04356.7 ESA03063.1 - 0.051 13.1 1.3 0.11 12.0 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF489) UQ_con PF00179.21 ESA03064.1 - 4.3e-48 162.2 0.0 5e-48 162.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA03064.1 - 2.1e-05 24.2 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 ESA03064.1 - 0.0091 15.6 0.1 0.018 14.7 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 ESA03064.1 - 0.033 14.0 0.3 0.045 13.6 0.2 1.5 1 1 0 1 1 1 0 RWD domain PS_Dcarbxylase PF02666.10 ESA03065.1 - 3.3e-71 238.7 0.0 3e-53 180.1 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylserine decarboxylase Peptidase_M23 PF01551.17 ESA03065.1 - 0.12 12.4 0.0 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 Peptidase family M23 Peptidase_M16 PF00675.15 ESA03066.1 - 1.2e-30 106.1 0.2 2.1e-30 105.4 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESA03066.1 - 1e-18 67.7 0.0 4.3e-18 65.6 0.0 2.1 3 0 0 3 3 3 1 Peptidase M16 inactive domain UCH_1 PF13423.1 ESA03067.1 - 7.8e-24 84.6 0.0 3.6e-23 82.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.24 ESA03067.1 - 2.1e-14 53.3 0.4 3.7e-13 49.2 0.3 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Hist_deacetyl PF00850.14 ESA03068.1 - 3.2e-80 269.7 0.0 4.1e-80 269.3 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain RRS1 PF04939.7 ESA03069.1 - 7.3e-61 204.4 2.2 1.1e-60 203.9 1.5 1.2 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Radial_spoke_3 PF06098.6 ESA03069.1 - 0.16 10.9 3.7 0.28 10.1 2.6 1.3 1 0 0 1 1 1 0 Radial spoke protein 3 Slx4 PF09494.5 ESA03070.1 - 0.011 15.4 1.3 0.023 14.4 0.9 1.5 1 0 0 1 1 1 0 Slx4 endonuclease Methyltransf_15 PF09445.5 ESA03070.1 - 0.031 13.8 0.3 0.046 13.2 0.2 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Ras PF00071.17 ESA03072.1 - 3.2e-34 117.6 0.2 3.8e-34 117.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA03072.1 - 2.7e-22 79.4 0.1 1e-21 77.6 0.0 1.8 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESA03072.1 - 2.3e-08 33.4 0.1 2.8e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA03072.1 - 4.4e-08 32.5 0.2 5.3e-08 32.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA03072.1 - 0.00039 19.9 0.0 0.0028 17.0 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA03072.1 - 0.0043 16.9 0.0 0.0061 16.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 ESA03072.1 - 0.0096 14.6 0.9 0.028 13.1 0.6 1.9 1 1 0 1 1 1 1 G-protein alpha subunit DLIC PF05783.6 ESA03072.1 - 0.01 14.5 0.3 2.1 6.9 0.0 2.0 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) SRPRB PF09439.5 ESA03072.1 - 0.069 12.3 0.0 0.083 12.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit F-box-like PF12937.2 ESA03073.1 - 2.5e-06 27.0 0.4 7.9e-06 25.5 0.3 1.8 1 0 0 1 1 1 1 F-box-like DUF1132 PF06575.7 ESA03074.1 - 0.1 12.8 0.4 0.19 12.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1132) Mit_proteolip PF08039.6 ESA03075.1 - 0.14 12.1 1.4 17 5.4 0.0 2.6 2 1 0 2 2 2 0 Mitochondrial proteolipid VGCC_alpha2 PF08473.6 ESA03076.1 - 0.052 13.3 0.2 0.074 12.8 0.1 1.5 1 1 0 1 1 1 0 Neuronal voltage-dependent calcium channel alpha 2acd SAP PF02037.22 ESA03077.1 - 0.054 13.0 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 SAP domain GDPD PF03009.12 ESA03081.1 - 1.6e-65 221.1 0.0 2.1e-65 220.7 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family BLVR PF06375.6 ESA03081.1 - 0.011 15.5 0.3 0.017 14.9 0.2 1.3 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) PI-PLC-X PF00388.14 ESA03081.1 - 0.057 12.8 0.0 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain F-box-like PF12937.2 ESA03082.1 - 0.0019 17.8 0.8 0.0063 16.2 0.5 1.9 1 0 0 1 1 1 1 F-box-like Bowman-Birk_leg PF00228.15 ESA03082.1 - 2.7 7.9 5.7 0.31 10.8 0.5 2.0 2 0 0 2 2 2 0 Bowman-Birk serine protease inhibitor family Abhydrolase_6 PF12697.2 ESA03084.1 - 0.0039 17.0 0.0 0.0084 16.0 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA03084.1 - 0.0074 16.0 0.0 0.028 14.1 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family WAC_Acf1_DNA_bd PF10537.4 ESA03084.1 - 0.2 11.8 1.9 0.4 10.8 0.4 2.1 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal Beta-Casp PF10996.3 ESA03085.1 - 2.8e-34 117.7 0.0 5.1e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 ESA03085.1 - 2.6e-17 63.1 0.5 3.9e-17 62.5 0.3 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESA03085.1 - 4.1e-11 42.8 0.3 7e-11 42.0 0.2 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 ESA03085.1 - 6.5e-09 35.7 0.2 1.4e-08 34.5 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 ESA03085.1 - 0.00018 21.2 0.0 0.00038 20.2 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase CPSF73-100_C PF11718.3 ESA03086.1 - 1.6e-50 171.4 6.0 2e-50 171.1 4.2 1.1 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term TRAPPC10 PF12584.3 ESA03086.1 - 0.015 14.8 0.2 0.027 13.9 0.2 1.4 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 tRNA_m1G_MT PF01746.16 ESA03087.1 - 9.7e-32 110.0 0.1 1.1e-31 109.9 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Trm112p PF03966.11 ESA03088.1 - 4.9e-06 26.7 0.1 6.6e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Trm112p-like protein SinI PF08671.5 ESA03088.1 - 0.17 11.3 1.0 0.24 10.8 0.1 1.7 2 0 0 2 2 2 0 Anti-repressor SinI NCA2 PF08637.5 ESA03091.1 - 5.1e-79 265.1 0.5 9.1e-79 264.3 0.3 1.4 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Symplekin_C PF12295.3 ESA03091.1 - 0.021 14.7 1.0 0.11 12.3 0.7 2.2 1 1 0 1 1 1 0 Symplekin tight junction protein C terminal CK_II_beta PF01214.13 ESA03092.1 - 4.5e-83 277.2 0.0 5.2e-83 277.0 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RNA_pol_Rpc34 PF05158.7 ESA03093.1 - 1.3e-55 188.8 3.6 1.8e-55 188.3 2.3 1.3 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.14 ESA03093.1 - 0.00024 20.7 3.5 0.11 12.2 0.3 2.9 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.7 ESA03093.1 - 0.013 15.3 2.7 0.11 12.4 0.2 2.9 3 0 0 3 3 3 0 B-block binding subunit of TFIIIC HTH_45 PF14947.1 ESA03093.1 - 0.022 14.5 5.0 0.21 11.4 1.1 2.7 1 1 1 2 2 2 0 Winged helix-turn-helix HTH_24 PF13412.1 ESA03093.1 - 0.024 14.0 1.0 0.06 12.7 0.7 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Ribosomal_S25 PF03297.10 ESA03093.1 - 0.046 13.7 2.1 0.11 12.5 1.3 1.7 1 1 0 1 1 1 0 S25 ribosomal protein RPA_C PF08784.6 ESA03093.1 - 0.099 13.0 1.9 2.9 8.3 0.2 2.6 2 0 0 2 2 2 0 Replication protein A C terminal Penicillinase_R PF03965.11 ESA03093.1 - 1.4 8.9 6.0 0.23 11.5 0.6 2.3 2 1 1 3 3 3 0 Penicillinase repressor Lipoprotein_20 PF13942.1 ESA03093.1 - 1.5 8.3 6.5 3.5 7.1 3.3 2.1 1 1 1 2 2 2 0 YfhG lipoprotein Asparaginase_2 PF01112.13 ESA03094.1 - 6.9e-72 241.8 0.1 8.2e-72 241.6 0.1 1.1 1 0 0 1 1 1 1 Asparaginase 2-Hacid_dh_C PF02826.14 ESA03095.1 - 4.4e-52 175.8 0.0 7.7e-52 175.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 ESA03095.1 - 7.5e-35 119.2 0.0 9.7e-35 118.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 ESA03095.1 - 5.8e-05 22.9 0.5 0.00018 21.4 0.1 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.20 ESA03095.1 - 0.0044 16.4 0.0 0.013 14.9 0.0 1.9 1 0 0 1 1 1 1 ACT domain AdoHcyase_NAD PF00670.16 ESA03095.1 - 0.034 13.9 0.1 0.089 12.6 0.0 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_10 PF13460.1 ESA03096.1 - 1.1e-21 77.6 0.0 1.6e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESA03096.1 - 2.4e-13 50.0 0.1 1.3e-11 44.3 0.1 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA03096.1 - 3.8e-12 45.4 0.0 1.6e-10 40.1 0.0 2.2 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 ESA03096.1 - 1.2e-11 44.0 0.0 6.4e-10 38.3 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 ESA03096.1 - 5e-11 42.3 0.0 1.7e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 ESA03096.1 - 3e-09 36.1 0.0 0.00027 19.9 0.1 3.2 1 1 1 2 2 2 2 Male sterility protein Saccharop_dh PF03435.13 ESA03096.1 - 0.0024 16.9 0.0 0.0049 15.9 0.0 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase adh_short PF00106.20 ESA03096.1 - 0.016 15.1 0.0 0.035 14.0 0.0 1.5 2 0 0 2 2 2 0 short chain dehydrogenase Polysacc_synt_2 PF02719.10 ESA03096.1 - 0.068 12.0 0.0 0.13 11.0 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Pex24p PF06398.6 ESA03097.1 - 2.4e-10 39.7 11.2 3.4e-10 39.2 5.7 2.0 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin DUF4476 PF14771.1 ESA03097.1 - 0.019 14.9 0.7 0.33 11.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) Glyco_transf_5 PF08323.6 ESA03098.1 - 4e-18 65.7 0.1 1e-17 64.4 0.1 1.7 1 1 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 ESA03098.1 - 3.3e-17 62.4 0.0 1.4e-16 60.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESA03098.1 - 9.7e-07 29.0 0.0 1.9e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Gln-synt_C PF00120.19 ESA03099.1 - 2.5e-62 210.3 0.0 8e-62 208.7 0.0 1.7 2 0 0 2 2 2 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.9 ESA03099.1 - 2e-29 102.9 0.0 3.1e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.16 ESA03099.1 - 0.0021 17.2 0.0 0.0054 15.9 0.0 1.7 1 0 0 1 1 1 1 TatD related DNase Matrilin_ccoil PF10393.4 ESA03100.1 - 0.013 14.8 0.6 0.045 13.1 0.0 2.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Laminin_II PF06009.7 ESA03100.1 - 0.072 12.8 0.2 0.072 12.8 0.1 2.6 3 0 0 3 3 3 0 Laminin Domain II SlyX PF04102.7 ESA03100.1 - 0.14 12.5 0.1 0.14 12.5 0.1 2.6 3 0 0 3 3 3 0 SlyX NPV_P10 PF05531.7 ESA03100.1 - 0.16 12.2 2.2 0.79 10.0 0.1 2.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Bromodomain PF00439.20 ESA03102.1 - 5.1e-13 48.7 2.8 5.2e-13 48.7 2.0 1.0 1 0 0 1 1 1 1 Bromodomain DsrH PF04077.7 ESA03104.1 - 0.088 12.4 0.0 4.6 6.9 0.0 2.4 2 0 0 2 2 2 0 DsrH like protein SBDS PF01172.13 ESA03106.1 - 0.074 12.8 0.8 0.083 12.6 0.1 1.6 2 0 0 2 2 2 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein TcdA_TcdB_pore PF12920.2 ESA03106.1 - 0.098 10.5 7.0 0.1 10.5 4.8 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain DUF261 PF03196.8 ESA03106.1 - 0.13 12.1 1.8 0.17 11.8 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF261 MerB PF03243.10 ESA03107.1 - 0.00045 20.0 2.7 0.071 12.9 0.3 2.2 2 0 0 2 2 2 2 Alkylmercury lyase Fer4_8 PF13183.1 ESA03107.1 - 0.02 14.9 1.9 2.7 8.0 0.5 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF2408 PF10303.4 ESA03107.1 - 0.049 13.7 1.0 5.7 7.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) TetR_C_2 PF08361.6 ESA03107.1 - 0.058 13.3 1.3 0.71 9.7 0.1 2.2 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region ACDC PF14733.1 ESA03107.1 - 0.11 12.6 4.9 5.3 7.2 0.2 2.4 2 0 0 2 2 2 0 AP2-coincident C-terminal Hyccin PF09790.4 ESA03107.1 - 0.12 11.2 1.7 4.4 6.0 0.1 2.1 2 0 0 2 2 2 0 Hyccin DUF4134 PF13572.1 ESA03107.1 - 0.12 12.4 0.5 4.2 7.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4134) DUF2296 PF10058.4 ESA03107.1 - 0.3 10.8 4.4 4.1 7.2 0.2 2.5 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) DUF326 PF03860.11 ESA03107.1 - 3.3 7.6 8.1 11 6.0 0.7 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) Glycos_transf_2 PF00535.21 ESA03108.1 - 8.5e-11 41.8 0.1 2.6e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 ESA03108.1 - 1.4e-06 27.6 0.1 3.4e-06 26.3 0.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.1 ESA03108.1 - 0.001 18.9 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 ROK PF00480.15 ESA03110.1 - 0.00025 20.9 0.0 0.00032 20.5 0.0 1.1 1 0 0 1 1 1 1 ROK family Amidase PF01425.16 ESA03111.1 - 4.1e-105 352.1 0.0 6.3e-105 351.5 0.0 1.2 1 0 0 1 1 1 1 Amidase PGAP1 PF07819.8 ESA03111.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein PB1 PF00564.19 ESA03112.1 - 5.8e-09 35.5 0.0 1.2e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 PB1 domain CUE PF02845.11 ESA03112.1 - 0.038 13.4 1.0 0.06 12.8 0.1 1.8 2 0 0 2 2 2 0 CUE domain OAD_gamma PF04277.8 ESA03112.1 - 0.051 13.9 1.2 0.15 12.4 0.8 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PB1 PF00564.19 ESA03113.1 - 3.9e-10 39.2 0.0 7.7e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Pex14_N PF04695.8 ESA03113.1 - 2.4 8.2 7.5 0.78 9.7 1.6 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GAGA_bind PF06217.7 ESA03113.1 - 2.5 8.0 8.6 0.76 9.6 2.2 2.0 2 0 0 2 2 2 0 GAGA binding protein-like family Pkinase_Tyr PF07714.12 ESA03115.1 - 4.8e-33 114.3 0.6 4.4e-31 107.8 0.1 3.7 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03115.1 - 2.3e-29 102.3 2.3 5.9e-29 100.9 1.6 1.8 1 0 0 1 1 1 1 Protein kinase domain HlyD_3 PF13437.1 ESA03115.1 - 9.2e-05 22.7 0.0 37 4.7 0.0 5.9 6 0 0 6 6 6 0 HlyD family secretion protein DUF2373 PF10180.4 ESA03115.1 - 0.003 17.0 33.4 2 7.9 0.1 8.5 8 0 0 8 8 8 4 Uncharacterised conserved protein (DUF2373) DUF4134 PF13572.1 ESA03115.1 - 0.016 15.2 3.2 33 4.6 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4134) BACK PF07707.10 ESA03115.1 - 0.075 12.8 7.7 25 4.7 0.0 5.4 5 0 0 5 5 5 0 BTB And C-terminal Kelch APH PF01636.18 ESA03115.1 - 0.24 11.1 0.0 0.45 10.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Frag1 PF10277.4 ESA03116.1 - 2.8e-38 131.5 15.0 3.2e-38 131.3 10.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF998 PF06197.8 ESA03116.1 - 0.0012 18.1 1.2 0.0012 18.1 0.8 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF998) DUF606 PF04657.8 ESA03116.1 - 0.22 11.5 0.2 0.22 11.5 0.1 1.9 3 0 0 3 3 3 0 Protein of unknown function, DUF606 PEPCK_ATP PF01293.15 ESA03117.1 - 1.5e-222 739.1 0.0 1.8e-222 738.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase Epimerase PF01370.16 ESA03119.1 - 3.5e-22 78.9 0.1 8.9e-22 77.6 0.1 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESA03119.1 - 1.5e-12 47.0 0.1 2.5e-12 46.3 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 ESA03119.1 - 7.8e-10 37.9 0.0 1.3e-09 37.1 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESA03119.1 - 7.9e-07 28.2 0.2 1.5e-06 27.3 0.1 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 ESA03119.1 - 2.5e-06 27.6 0.0 5.2e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ESA03119.1 - 0.0013 18.6 0.0 0.0025 17.7 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 ESA03119.1 - 0.019 13.9 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase KR PF08659.5 ESA03119.1 - 0.04 13.5 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 KR domain DUF4288 PF14119.1 ESA03119.1 - 0.042 13.9 0.9 0.11 12.6 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) Calreticulin PF00262.13 ESA03120.1 - 1.6e-162 540.3 18.3 2.6e-162 539.6 12.7 1.3 1 0 0 1 1 1 1 Calreticulin family GTP_EFTU PF00009.22 ESA03121.1 - 1.1e-44 152.1 0.0 1.6e-44 151.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESA03121.1 - 2.3e-29 101.3 0.0 5.7e-29 100.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 ESA03121.1 - 2.6e-22 78.5 0.0 7.6e-22 76.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 ESA03121.1 - 7e-13 48.4 0.2 1.7e-12 47.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 ESA03121.1 - 6.3e-08 32.3 0.0 1.8e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 ESA03121.1 - 2.9e-06 27.7 0.2 7.8e-06 26.3 0.1 1.8 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESA03121.1 - 3e-06 27.1 0.1 5.7e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA03121.1 - 0.0013 18.5 0.4 1.3 8.7 0.0 2.6 1 1 0 2 2 2 2 Dynamin family Septin PF00735.13 ESA03121.1 - 0.019 14.0 0.0 0.031 13.2 0.0 1.3 1 0 0 1 1 1 0 Septin Ras PF00071.17 ESA03121.1 - 0.031 13.6 0.3 0.1 11.9 0.2 1.8 1 1 0 1 1 1 0 Ras family DUF2638 PF10937.3 ESA03122.1 - 5.9e-06 27.2 0.8 2.5e-05 25.2 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2638) Spectrin PF00435.16 ESA03125.1 - 0.13 12.5 6.7 0.31 11.3 4.6 1.6 1 0 0 1 1 1 0 Spectrin repeat Med15_fungi PF05397.7 ESA03125.1 - 0.15 12.0 1.0 0.28 11.1 0.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 15 Dsh_C PF12316.3 ESA03125.1 - 7.9 6.5 13.8 9.5 6.2 9.5 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal MFS_2 PF13347.1 ESA03126.1 - 4.6e-07 28.6 20.9 1.7e-05 23.4 14.4 2.3 1 1 0 1 1 1 1 MFS/sugar transport protein PUCC PF03209.10 ESA03126.1 - 8.9e-05 21.3 1.0 0.00017 20.4 0.7 1.4 1 0 0 1 1 1 1 PUCC protein DUF1228 PF06779.9 ESA03126.1 - 0.0054 16.7 0.4 0.27 11.3 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1228) MFS_1_like PF12832.2 ESA03126.1 - 0.0091 15.7 0.0 0.0091 15.7 0.0 3.8 3 1 0 3 3 3 1 MFS_1 like family DUF3671 PF12420.3 ESA03126.1 - 2.1 8.3 10.7 0.25 11.3 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function Urm1 PF09138.6 ESA03127.1 - 1.5e-37 127.6 0.0 1.6e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 ESA03127.1 - 1.6e-06 28.4 0.0 1.9e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 ThiS family Helicase_Sgs1 PF11408.3 ESA03127.1 - 0.003 17.3 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 Sgs1 RecQ helicase Mso1_Sec1_bdg PF14475.1 ESA03128.1 - 1.3e-07 30.9 0.1 2.8e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Sec1-binding region of Mso1 zinc_ribbon_6 PF14599.1 ESA03128.1 - 0.059 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Zinc-ribbon COX17 PF05051.8 ESA03129.1 - 4.9e-22 77.6 6.2 6.3e-22 77.3 4.3 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Mucin PF01456.12 ESA03129.1 - 7.3 6.3 20.5 8.8 6.0 14.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein PDCD2_C PF04194.8 ESA03130.1 - 6.8e-35 120.0 1.0 6.8e-35 120.0 0.7 1.9 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.13 ESA03130.1 - 4.7e-08 32.7 8.3 4.7e-08 32.7 5.8 3.0 3 1 0 3 3 3 1 MYND finger Cys_rich_CPXG PF14255.1 ESA03130.1 - 0.001 18.8 3.7 0.53 10.1 0.4 3.6 3 0 0 3 3 3 2 Cysteine-rich CPXCG Lar_restr_allev PF14354.1 ESA03130.1 - 0.023 14.9 0.0 0.023 14.9 0.0 3.4 3 1 0 3 3 3 0 Restriction alleviation protein Lar zf-tcix PF14952.1 ESA03130.1 - 0.37 10.1 0.0 0.37 10.1 0.0 3.5 3 1 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding UPF0029 PF01205.14 ESA03131.1 - 1.3e-28 98.8 0.0 2.4e-28 97.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 ESA03131.1 - 4.7e-16 58.6 1.1 8.9e-16 57.7 0.8 1.5 1 0 0 1 1 1 1 RWD domain 7TM_GPCR_Srsx PF10320.4 ESA03131.1 - 0.094 11.8 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx DEAD PF00270.24 ESA03132.1 - 7.4e-48 162.2 0.1 9.3e-47 158.6 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA03132.1 - 5.2e-23 80.6 0.0 1.3e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESA03132.1 - 0.00065 18.5 0.0 0.0011 17.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 ESA03132.1 - 0.0058 16.4 0.1 0.074 12.8 0.0 2.8 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit MIF4G PF02854.14 ESA03133.1 - 0.00015 21.2 0.8 0.00015 21.2 0.6 2.2 2 1 1 3 3 3 1 MIF4G domain Lin-8 PF03353.10 ESA03133.1 - 0.37 10.0 16.6 0.38 10.0 6.1 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Aminotran_4 PF01063.14 ESA03134.1 - 1.2e-27 96.9 0.0 2.8e-27 95.7 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class IV DUF3504 PF12012.3 ESA03135.1 - 3.4e-07 30.2 0.0 1e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3504) Phage_integrase PF00589.17 ESA03135.1 - 0.0025 17.4 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family DUF3504 PF12012.3 ESA03136.1 - 0.0058 16.4 0.0 0.016 14.9 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3504) Carb_bind PF10645.4 ESA03136.1 - 0.045 13.5 1.7 0.097 12.4 1.2 1.6 1 0 0 1 1 1 0 Carbohydrate binding Phage_int_SAM_1 PF02899.12 ESA03136.1 - 0.082 13.0 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain EnY2 PF10163.4 ESA03139.1 - 1.7e-21 75.8 2.7 2.5e-21 75.4 1.9 1.3 1 0 0 1 1 1 1 Transcription factor e(y)2 CAAP1 PF15335.1 ESA03139.1 - 0.004 17.3 2.2 0.069 13.3 0.5 2.4 2 1 0 2 2 2 1 Caspase activity and apoptosis inhibitor 1 Ribosomal_L31e PF01198.14 ESA03139.1 - 0.025 14.2 0.1 0.039 13.6 0.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L31e DUF2443 PF10398.4 ESA03139.1 - 0.12 12.2 1.7 0.12 12.1 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2443) ENTH PF01417.15 ESA03139.1 - 0.16 11.7 2.4 0.26 11.1 1.7 1.4 1 1 0 1 1 1 0 ENTH domain DUF1539 PF07560.6 ESA03139.1 - 0.2 11.5 1.6 0.35 10.7 1.1 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) RPA_interact_N PF14766.1 ESA03139.1 - 0.33 10.4 5.9 0.79 9.2 3.7 1.9 1 1 1 2 2 2 0 Replication protein A interacting N-terminal DUF445 PF04286.7 ESA03139.1 - 0.56 9.6 3.7 0.68 9.4 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ING PF12998.2 ESA03139.1 - 0.79 10.0 5.9 2.8 8.2 4.1 2.0 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding TBCA PF02970.11 ESA03139.1 - 1 9.5 5.8 0.16 12.0 0.9 1.9 2 0 0 2 2 2 0 Tubulin binding cofactor A SCA7 PF08313.7 ESA03140.1 - 1.2e-27 95.2 1.6 1.2e-27 95.2 1.1 2.3 3 0 0 3 3 3 1 SCA7, zinc-binding domain Dicty_REP PF05086.7 ESA03140.1 - 0.96 7.1 8.6 1.1 6.9 5.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF334 PF03904.8 ESA03140.1 - 7.3 5.8 7.0 15 4.8 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF334) PapD-like PF14874.1 ESA03141.1 - 7.5e-12 45.1 0.5 0.041 13.8 0.0 6.3 7 0 0 7 7 7 4 Flagellar-associated PapD-like Bestrophin PF01062.16 ESA03142.1 - 8e-58 195.6 2.8 2e-56 191.0 1.9 2.1 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DAGK_prokar PF01219.14 ESA03142.1 - 0.21 11.2 1.5 0.39 10.3 0.1 2.0 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase Ribosomal_L3 PF00297.17 ESA03143.1 - 5.9e-121 402.8 10.3 7.2e-121 402.5 7.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 ABC_tran_2 PF12848.2 ESA03143.1 - 0.41 10.5 8.5 0.15 11.9 3.8 1.8 2 0 0 2 2 2 0 ABC transporter DUF1649 PF07855.7 ESA03144.1 - 9.2e-50 168.4 2.4 1.1e-49 168.2 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1649) HD_assoc PF13286.1 ESA03148.1 - 0.039 14.2 0.5 18 5.6 0.0 2.9 3 0 0 3 3 3 0 Phosphohydrolase-associated domain YdjO PF14169.1 ESA03148.1 - 0.086 12.2 0.1 0.26 10.7 0.1 1.9 1 0 0 1 1 1 0 Cold-inducible protein YdjO IstB_IS21 PF01695.12 ESA03149.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2737 PF10930.3 ESA03150.1 - 0.00059 19.3 0.2 0.00099 18.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2737) Thymidylat_synt PF00303.14 ESA03153.1 - 0.017 14.1 0.3 0.024 13.6 0.2 1.3 1 0 0 1 1 1 0 Thymidylate synthase Peptidase_C3 PF00548.15 ESA03153.1 - 0.13 12.1 3.0 0.35 10.6 1.6 1.8 1 1 1 2 2 2 0 3C cysteine protease (picornain 3C) CBP4 PF07960.6 ESA03154.1 - 2.2e-12 46.7 0.1 2.4e-12 46.5 0.1 1.1 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.1 ESA03154.1 - 4.4e-09 35.9 0.0 6.9e-09 35.3 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4574) IPP-2 PF04979.9 ESA03154.1 - 0.0026 18.0 0.2 0.0031 17.7 0.2 1.1 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Sucrose_synth PF00862.14 ESA03154.1 - 0.12 10.2 0.0 0.15 9.9 0.0 1.0 1 0 0 1 1 1 0 Sucrose synthase E1-E2_ATPase PF00122.15 ESA03155.1 - 1.2e-23 83.3 0.8 2.1e-22 79.2 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 ESA03155.1 - 2.4e-16 60.4 0.0 1.4e-15 57.9 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA03155.1 - 1.5e-14 54.9 3.4 8.7e-11 42.6 2.7 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA03155.1 - 1.4e-10 40.9 0.0 5.4e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Fasciclin PF02469.17 ESA03156.1 - 6.6e-18 64.9 0.9 8.5e-18 64.5 0.2 1.4 2 0 0 2 2 2 1 Fasciclin domain SPX PF03105.14 ESA03157.1 - 2.8e-49 168.3 8.0 3.7e-49 167.9 5.5 1.2 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 ESA03157.1 - 8e-29 100.8 37.8 1.1e-28 100.4 26.2 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 ESA03157.1 - 4.4e-23 81.4 35.4 1.1e-17 63.6 11.8 2.3 1 1 1 2 2 2 2 Citrate transporter Methyltransf_3 PF01596.12 ESA03158.1 - 4.5e-38 130.3 0.0 5.3e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.14 ESA03158.1 - 2.3e-09 37.1 0.0 3.4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.1 ESA03158.1 - 4.5e-08 33.8 0.0 7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA03158.1 - 5.4e-05 23.7 0.0 7.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA03158.1 - 0.00011 21.8 0.7 0.00015 21.4 0.5 1.3 1 1 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 ESA03158.1 - 0.00051 19.4 0.0 0.0007 18.9 0.0 1.1 1 0 0 1 1 1 1 Cephalosporin hydroxylase MTS PF05175.9 ESA03158.1 - 0.00062 19.1 0.0 0.0009 18.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESA03158.1 - 0.0021 18.0 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESA03158.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF938 PF06080.7 ESA03158.1 - 0.037 13.5 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) AKAP7_NLS PF10469.4 ESA03159.1 - 0.098 12.3 0.1 0.099 12.3 0.1 1.0 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain 2-oxoacid_dh PF00198.18 ESA03162.1 - 8.5e-79 264.0 0.1 9.5e-79 263.9 0.1 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) DASH_Hsk3 PF08227.6 ESA03163.1 - 7e-09 35.7 3.3 8.9e-09 35.4 2.0 1.4 1 1 0 1 1 1 1 DASH complex subunit Hsk3 like Med4 PF10018.4 ESA03163.1 - 0.0001 21.7 0.8 0.00013 21.4 0.5 1.1 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 SlyX PF04102.7 ESA03163.1 - 0.00037 20.8 2.7 0.00058 20.1 1.9 1.3 1 0 0 1 1 1 1 SlyX ORF6C PF10552.4 ESA03163.1 - 0.0023 17.6 0.4 0.0026 17.4 0.3 1.1 1 0 0 1 1 1 1 ORF6C domain DUF3702 PF12486.3 ESA03163.1 - 0.0051 16.4 0.6 0.0068 16.0 0.4 1.1 1 0 0 1 1 1 1 ImpA domain protein DASH_Dad3 PF08656.5 ESA03163.1 - 0.006 16.2 0.7 0.0072 16.0 0.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad3 FlxA PF14282.1 ESA03163.1 - 0.014 15.3 1.8 0.017 15.0 1.2 1.3 1 0 0 1 1 1 0 FlxA-like protein Baculo_PEP_C PF04513.7 ESA03163.1 - 0.027 14.2 0.7 0.028 14.2 0.5 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 ESA03163.1 - 0.03 13.9 0.8 0.035 13.6 0.6 1.1 1 0 0 1 1 1 0 IncA protein Cob_adeno_trans PF01923.13 ESA03163.1 - 0.054 13.2 0.1 0.059 13.1 0.1 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase DASH_Spc34 PF08657.5 ESA03163.1 - 0.055 13.1 1.6 0.07 12.7 1.1 1.1 1 0 0 1 1 1 0 DASH complex subunit Spc34 UPF0449 PF15136.1 ESA03163.1 - 0.13 12.4 0.8 0.16 12.1 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 NTR2 PF15458.1 ESA03163.1 - 0.23 10.6 2.2 0.29 10.3 1.5 1.2 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Prefoldin_2 PF01920.15 ESA03163.1 - 0.39 10.4 4.4 0.52 10.1 3.1 1.2 1 0 0 1 1 1 0 Prefoldin subunit DivIC PF04977.10 ESA03163.1 - 0.88 9.1 4.4 1.2 8.6 3.0 1.2 1 0 0 1 1 1 0 Septum formation initiator Mg_trans_NIPA PF05653.9 ESA03164.1 - 3.2e-23 82.1 9.7 1.1e-11 44.2 1.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA03164.1 - 8.2e-06 26.0 1.4 8.2e-06 26.0 1.0 3.2 2 1 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA03164.1 - 0.0041 17.1 4.9 0.0041 17.1 3.4 3.8 3 1 1 4 4 4 1 EamA-like transporter family Mur_ligase_M PF08245.7 ESA03165.1 - 2e-08 34.5 0.1 2.7e-07 30.8 0.0 2.5 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 ESA03165.1 - 0.05 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Pkinase PF00069.20 ESA03169.1 - 1.1e-19 70.6 0.0 1.3e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03169.1 - 2.3e-18 66.2 0.0 2.9e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4286 PF14114.1 ESA03169.1 - 0.47 10.7 3.7 2.2 8.6 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) Apis_Csd PF11671.3 ESA03171.1 - 1.6 8.4 9.3 1.6 8.5 6.5 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein Tubulin PF00091.20 ESA03173.1 - 4.1e-70 235.9 0.0 5.4e-70 235.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESA03173.1 - 1.5e-51 173.6 0.0 2.4e-51 173.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 ESA03173.1 - 0.00081 18.8 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain tRNA-synt_2b PF00587.20 ESA03174.1 - 4.6e-37 127.2 1.3 8.5e-37 126.3 0.9 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 ESA03174.1 - 1e-23 83.3 3.5 1e-23 83.3 2.4 2.0 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DcpS PF05652.7 ESA03174.1 - 0.025 14.9 1.1 0.058 13.7 0.8 1.6 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal Hexapep PF00132.19 ESA03175.1 - 5e-10 38.4 13.2 2.5e-07 29.8 0.5 4.2 4 1 1 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESA03175.1 - 0.004 16.6 3.2 0.004 16.6 2.2 3.8 1 1 4 5 5 5 3 Hexapeptide repeat of succinyl-transferase GCV_H PF01597.14 ESA03176.1 - 1.6e-47 160.1 0.6 1.9e-47 159.9 0.4 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.17 ESA03176.1 - 0.029 14.0 0.1 0.049 13.2 0.1 1.4 1 0 0 1 1 1 0 Biotin-requiring enzyme RnfC_N PF13375.1 ESA03176.1 - 0.081 12.6 0.1 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain DUF3128 PF11326.3 ESA03177.1 - 2.2e-20 72.5 2.8 2.8e-20 72.2 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) IPK PF03770.11 ESA03178.1 - 4.4e-58 196.1 0.0 8.2e-58 195.2 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Ribosomal_L34e PF01199.13 ESA03178.1 - 0.057 13.6 0.1 0.23 11.6 0.1 2.0 1 0 0 1 1 1 0 Ribosomal protein L34e CAF1A PF12253.3 ESA03178.1 - 0.16 12.0 5.4 0.046 13.8 0.9 2.2 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A PCI PF01399.22 ESA03179.1 - 3.2e-11 43.4 1.6 7.7e-11 42.2 0.1 2.4 3 0 0 3 3 3 1 PCI domain tRNA_anti-codon PF01336.20 ESA03180.1 - 2e-11 43.5 0.1 3.4e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2 PF00152.15 ESA03180.1 - 4e-06 25.8 0.8 4e-06 25.8 0.5 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-like PF12869.2 ESA03180.1 - 0.0098 15.3 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 tRNA_anti-like Peptidase_S49_N PF08496.5 ESA03180.1 - 3.2 7.5 6.6 5 6.8 4.6 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal POX PF07526.6 ESA03180.1 - 4.6 7.4 7.1 5.2 7.2 4.2 1.6 2 0 0 2 2 2 0 Associated with HOX Pkinase_Tyr PF07714.12 ESA03182.1 - 2.3e-38 131.7 0.1 1.9e-35 122.2 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA03182.1 - 2.5e-33 115.3 1.0 6.7e-31 107.3 0.7 2.5 2 0 0 2 2 2 2 Protein kinase domain Sel1 PF08238.7 ESA03182.1 - 2.6e-09 37.4 6.4 1e-07 32.3 0.0 3.8 3 0 0 3 3 3 2 Sel1 repeat DUF2973 PF11189.3 ESA03183.1 - 0.048 13.4 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) SQS_PSY PF00494.14 ESA03184.1 - 5.3e-39 134.1 0.0 6.4e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase TPT PF03151.11 ESA03185.1 - 0.00011 21.9 7.0 0.00011 21.9 4.9 3.4 3 1 0 3 3 3 2 Triose-phosphate Transporter family EamA PF00892.15 ESA03185.1 - 0.00011 22.1 12.2 0.00011 22.1 8.4 2.9 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 ESA03185.1 - 0.006 16.7 7.6 0.006 16.7 5.3 3.2 3 1 0 3 3 3 1 Multidrug resistance efflux transporter MULE PF10551.4 ESA03186.1 - 1.3e-14 54.1 0.1 1.3e-14 54.1 0.1 2.8 3 1 0 4 4 4 1 MULE transposase domain FAR1 PF03101.10 ESA03186.1 - 6.3e-09 36.2 2.4 1.5e-08 35.0 1.7 1.6 1 0 0 1 1 1 1 FAR1 DNA-binding domain Merozoite_SPAM PF07133.6 ESA03189.1 - 0.018 14.9 10.1 0.02 14.8 7.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nucleo_P87 PF07267.6 ESA03189.1 - 0.082 11.5 10.9 0.092 11.4 7.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TMEM51 PF15345.1 ESA03189.1 - 2.2 7.9 6.6 2.5 7.7 4.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Mst1_SARAH PF11629.3 ESA03190.1 - 0.077 12.8 1.3 0.077 12.8 0.9 1.7 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 zf-C2H2 PF00096.21 ESA03193.1 - 1.5e-05 25.0 1.1 4.3e-05 23.6 0.8 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA03193.1 - 0.00088 19.4 0.4 0.004 17.3 0.2 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA03193.1 - 0.029 14.5 0.7 0.085 13.0 0.5 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.5 ESA03193.1 - 0.053 14.1 1.6 0.1 13.1 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DDE_Tnp_ISAZ013 PF07592.6 ESA03194.1 - 0.0023 16.7 0.0 0.0031 16.3 0.0 1.1 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain PQQ_2 PF13360.1 ESA03195.1 - 0.001 18.5 2.3 0.0013 18.2 0.5 1.8 2 0 0 2 2 2 1 PQQ-like domain PQQ_3 PF13570.1 ESA03195.1 - 0.0021 18.2 0.2 0.2 11.9 0.0 3.7 4 0 0 4 4 4 1 PQQ-like domain Glyco_transf_34 PF05637.7 ESA03197.1 - 1.5e-23 83.5 0.2 3.4e-22 79.1 0.2 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 ESA03197.1 - 6e-07 28.9 0.0 1.3e-06 27.8 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_8 PF01501.15 ESA03197.1 - 0.0012 18.2 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 ESA03197.1 - 0.0079 15.9 0.2 0.022 14.5 0.1 1.7 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Totivirus_coat PF05518.6 ESA03200.1 - 0.012 13.5 3.4 0.013 13.3 2.4 1.0 1 0 0 1 1 1 0 Totivirus coat protein ORC6 PF05460.8 ESA03200.1 - 6.9 5.6 9.2 7.7 5.5 6.4 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) WW PF00397.21 ESA03201.1 - 1e-06 28.4 2.3 2.3e-06 27.3 1.6 1.6 1 0 0 1 1 1 1 WW domain Arb1 PF09692.5 ESA03202.1 - 3.3e-59 200.7 0.3 3.3e-59 200.7 0.2 1.9 2 1 0 2 2 2 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Rieske PF00355.21 ESA03203.1 - 2e-08 33.7 0.0 2.4e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF4203 PF13886.1 ESA03204.1 - 1.7e-30 106.0 36.3 2.6e-30 105.4 25.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF3040 PF11239.3 ESA03204.1 - 0.16 11.9 0.2 0.16 11.9 0.2 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) zf-C2H2 PF00096.21 ESA03205.1 - 0.00034 20.7 22.9 0.056 13.8 1.0 4.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA03205.1 - 0.008 16.4 25.8 0.19 12.1 1.2 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger PHD PF00628.24 ESA03205.1 - 0.018 14.7 10.7 2.1 8.0 4.9 2.9 2 0 0 2 2 2 0 PHD-finger zinc_ribbon_5 PF13719.1 ESA03205.1 - 0.1 12.2 3.7 0.59 9.7 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ESA03205.1 - 0.27 10.9 4.8 0.77 9.5 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2HC_2 PF13913.1 ESA03205.1 - 2.8 7.7 11.2 0.84 9.3 1.6 3.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Tnp_P_element_C PF12596.3 ESA03207.1 - 2.3 8.6 6.6 5.7 7.3 3.8 2.0 1 1 1 2 2 2 0 87kDa Transposase RNase_T PF00929.19 ESA03208.1 - 1.5e-21 77.4 0.0 2.9e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DUF4391 PF14335.1 ESA03208.1 - 0.0099 15.2 0.1 0.0099 15.2 0.1 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4391) ScpA_ScpB PF02616.9 ESA03208.1 - 0.37 10.3 4.9 0.54 9.7 2.6 1.8 2 0 0 2 2 2 0 ScpA/B protein DUF791 PF05631.9 ESA03209.1 - 4.9e-99 331.3 13.7 8.2e-99 330.6 9.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 ESA03209.1 - 7.3e-29 100.5 28.1 3.1e-28 98.5 18.5 2.4 2 1 1 3 3 3 1 Major Facilitator Superfamily Vpu PF00558.14 ESA03209.1 - 0.1 12.1 0.0 0.81 9.2 0.0 2.3 2 0 0 2 2 2 0 Vpu protein DUF3285 PF11688.3 ESA03209.1 - 9.8 5.8 11.7 5.8 6.6 2.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3285) Pyridoxal_deC PF00282.14 ESA03212.1 - 5.6e-134 446.2 0.0 6.6e-134 446.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DUF1767 PF08585.7 ESA03213.1 - 0.00043 20.5 0.0 0.0012 19.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1767) Pkinase_Tyr PF07714.12 ESA03215.1 - 7.5e-14 51.4 0.1 1.4e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03215.1 - 5.5e-10 38.8 0.7 2.1e-09 36.9 0.1 2.1 2 0 0 2 2 2 1 Protein kinase domain FrhB_FdhB_C PF04432.8 ESA03215.1 - 0.00073 18.9 2.3 0.026 13.9 0.1 2.6 2 0 0 2 2 2 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus BCS1_N PF08740.6 ESA03215.1 - 0.058 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 BCS1 N terminal INCENP_ARK-bind PF03941.10 ESA03215.1 - 0.085 12.7 0.4 1.5 8.7 0.1 2.5 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region CENP-X PF09415.5 ESA03215.1 - 0.096 12.5 0.0 0.25 11.1 0.0 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X SprT-like PF10263.4 ESA03215.1 - 0.22 11.1 2.3 0.41 10.3 0.2 2.1 2 0 0 2 2 2 0 SprT-like family Zn_Tnp_IS91 PF14319.1 ESA03215.1 - 0.68 9.4 11.3 0.036 13.5 0.9 2.9 2 1 1 3 3 3 0 Transposase zinc-binding domain ADK_lid PF05191.9 ESA03215.1 - 1.5 8.5 7.9 7.7 6.2 2.4 2.6 2 0 0 2 2 2 0 Adenylate kinase, active site lid Ribosomal_L37e PF01907.14 ESA03215.1 - 3.6 7.4 8.0 12 5.7 0.6 2.6 2 0 0 2 2 2 0 Ribosomal protein L37e zf-ribbon_3 PF13248.1 ESA03215.1 - 4 6.7 11.9 6.6 6.0 1.7 2.6 2 0 0 2 2 2 0 zinc-ribbon domain cwf21 PF08312.7 ESA03216.1 - 1.9e-13 50.0 6.6 1.9e-13 50.0 4.6 3.2 3 0 0 3 3 3 1 cwf21 domain RRM_1 PF00076.17 ESA03217.1 - 2.5e-23 81.4 0.2 3e-10 39.5 0.1 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03217.1 - 1.3e-16 60.1 0.1 2.3e-08 33.7 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03217.1 - 2.6e-12 46.5 0.0 8.4e-05 22.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pyr_redox_3 PF13738.1 ESA03218.1 - 0.00013 22.0 0.0 0.58 10.1 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESA03218.1 - 0.00082 19.2 0.1 0.015 15.1 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA03218.1 - 0.0096 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA03218.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.9 ESA03218.1 - 0.093 11.1 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein CCDC155 PF14662.1 ESA03220.1 - 0.0016 18.0 1.6 0.002 17.7 1.1 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 Ribosomal_S2 PF00318.15 ESA03220.1 - 0.032 13.4 0.4 0.036 13.2 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 Pedibin PF08182.6 ESA03220.1 - 0.36 10.3 3.5 5.4 6.5 0.1 2.8 2 0 0 2 2 2 0 Pedibin/Hym-346 family DNA_pol_A PF00476.15 ESA03221.1 - 3e-93 312.4 0.0 4.3e-93 311.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 ESA03221.1 - 0.0032 16.9 0.3 0.036 13.5 0.2 2.5 1 1 0 1 1 1 1 3'-5' exonuclease DUF3791 PF12668.2 ESA03221.1 - 0.006 16.1 0.0 0.017 14.7 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3791) DUF2146 PF10220.4 ESA03222.1 - 1.4e-33 116.0 2.6 1.1e-31 109.7 1.8 2.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2146) Ribosomal_L21e PF01157.13 ESA03223.1 - 2.2e-42 142.8 5.5 2.2e-42 142.8 3.8 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e DUF1989 PF09347.5 ESA03223.1 - 0.092 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) Ribosomal_S4 PF00163.14 ESA03224.1 - 5.4e-30 103.6 1.1 1e-29 102.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 ESA03224.1 - 1.4e-14 53.2 1.2 1.4e-14 53.2 0.8 2.2 3 0 0 3 3 3 1 S4 domain TIP49 PF06068.8 ESA03225.1 - 1.3e-184 613.5 7.0 1.5e-184 613.3 4.9 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 ESA03225.1 - 4.3e-10 39.0 1.4 5.4e-06 25.6 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 ESA03225.1 - 7.4e-10 39.1 1.8 1.9e-06 28.0 0.0 3.1 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA03225.1 - 2.2e-07 30.6 0.1 0.0012 18.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) DnaB_C PF03796.10 ESA03225.1 - 4.9e-06 25.6 0.3 9.1e-06 24.7 0.2 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.16 ESA03225.1 - 5.7e-06 25.6 1.4 0.00048 19.3 0.4 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 ESA03225.1 - 8.9e-06 25.8 0.4 0.18 11.9 0.0 2.9 2 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 ESA03225.1 - 8.2e-05 22.6 0.0 0.00033 20.7 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.21 ESA03225.1 - 0.00035 20.0 0.5 0.93 8.9 0.1 3.0 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_14 PF13173.1 ESA03225.1 - 0.00044 20.1 0.1 0.77 9.6 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.1 ESA03225.1 - 0.0015 18.2 0.0 0.0042 16.7 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 ESA03225.1 - 0.0015 17.9 0.0 0.0033 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESA03225.1 - 0.0052 16.6 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA03225.1 - 0.0075 15.3 0.6 0.016 14.3 0.4 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_30 PF13604.1 ESA03225.1 - 0.0086 15.6 0.2 0.39 10.2 0.1 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 ESA03225.1 - 0.0091 15.4 0.1 0.019 14.4 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_11 PF13086.1 ESA03225.1 - 0.012 15.1 0.1 0.022 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.9 ESA03225.1 - 0.025 14.5 0.7 0.16 11.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) UPF0079 PF02367.12 ESA03225.1 - 0.025 14.1 0.1 0.072 12.7 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 ESA03225.1 - 0.026 15.3 0.0 0.06 14.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA03225.1 - 0.038 14.1 0.0 0.13 12.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 ESA03225.1 - 0.052 13.2 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.1 ESA03225.1 - 0.053 13.8 0.1 0.092 13.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 ESA03225.1 - 0.054 12.3 0.1 0.11 11.3 0.0 1.5 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_18 PF13238.1 ESA03225.1 - 0.065 13.5 0.3 0.32 11.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 ESA03225.1 - 0.079 12.7 1.0 0.43 10.3 0.1 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TPR_14 PF13428.1 ESA03226.1 - 1.3e-15 56.4 10.6 1.2 10.0 0.0 11.6 9 4 4 13 13 12 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA03226.1 - 2e-13 50.4 3.9 0.19 12.0 0.1 8.3 9 1 1 10 10 8 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03226.1 - 2.7e-10 40.0 13.0 0.022 14.6 0.3 8.4 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA03226.1 - 4.6e-10 38.6 27.1 0.0072 16.1 0.0 10.4 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03226.1 - 1.2e-09 37.6 17.1 0.0079 15.8 0.0 8.8 9 2 1 10 10 10 2 TPR repeat TPR_16 PF13432.1 ESA03226.1 - 2.8e-09 37.3 20.4 0.047 14.3 0.2 7.7 9 1 0 9 9 7 3 Tetratricopeptide repeat Suf PF05843.9 ESA03226.1 - 4.8e-09 36.3 22.8 0.0092 15.7 0.2 6.0 2 1 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_7 PF13176.1 ESA03226.1 - 6.7e-08 31.7 12.7 0.92 9.4 0.0 9.2 12 0 0 12 12 10 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 ESA03226.1 - 0.00013 21.7 9.7 3.3 7.5 0.1 6.4 6 1 0 6 6 6 1 Mad3/BUB1 homology region 1 TPR_8 PF13181.1 ESA03226.1 - 0.00019 20.9 15.4 0.2 11.5 0.0 7.5 9 0 0 9 9 7 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA03226.1 - 0.00024 21.1 8.4 2.4 8.3 0.0 6.1 8 0 0 8 8 6 2 Anaphase-promoting complex, cyclosome, subunit 3 NRDE-2 PF08424.5 ESA03226.1 - 0.0016 17.4 4.2 0.0016 17.4 2.9 5.8 4 2 1 5 5 5 1 NRDE-2, necessary for RNA interference TPR_1 PF00515.23 ESA03226.1 - 0.002 17.6 15.1 0.6 9.8 0.0 8.4 10 0 0 10 10 10 1 Tetratricopeptide repeat PPR_3 PF13812.1 ESA03226.1 - 0.0053 16.9 0.1 0.32 11.3 0.0 3.9 4 0 0 4 4 3 1 Pentatricopeptide repeat domain HAT PF02184.11 ESA03226.1 - 0.0076 15.9 10.9 22 4.8 0.1 7.5 7 0 0 7 7 7 0 HAT (Half-A-TPR) repeat RPN7 PF10602.4 ESA03226.1 - 0.017 14.4 0.0 0.78 9.1 0.0 3.2 3 0 0 3 3 3 0 26S proteasome subunit RPN7 PPR PF01535.15 ESA03226.1 - 0.049 13.6 7.6 0.35 10.9 0.0 5.1 6 0 0 6 6 4 0 PPR repeat SNAP PF14938.1 ESA03226.1 - 0.063 12.4 8.3 0.57 9.2 0.1 4.3 5 0 0 5 5 5 0 Soluble NSF attachment protein, SNAP TPR_10 PF13374.1 ESA03226.1 - 0.1 12.5 7.0 6.1 6.9 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 ESA03226.1 - 0.18 12.3 1.7 43 4.9 0.0 4.1 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA03226.1 - 0.25 11.8 15.2 27 5.5 0.0 7.6 8 1 0 8 8 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA03226.1 - 0.3 11.3 17.5 35 4.9 0.0 8.2 9 1 0 9 9 7 0 Tetratricopeptide repeat PUF PF00806.14 ESA03227.1 - 9.4e-69 223.2 17.7 1.4e-09 36.9 0.3 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF260 PF03195.9 ESA03227.1 - 0.0076 16.5 0.1 0.78 10.0 0.0 3.4 1 1 3 4 4 4 1 Protein of unknown function DUF260 Plasmod_dom_1 PF09715.5 ESA03227.1 - 0.26 11.2 1.7 2.4 8.1 0.0 2.8 3 0 0 3 3 3 0 Plasmodium protein of unknown function (Plasmod_dom_1) tRNA-synt_1g PF09334.6 ESA03228.1 - 0.052 12.2 0.1 0.052 12.2 0.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (M) DUF2225 PF09986.4 ESA03229.1 - 0.028 13.8 1.0 0.03 13.7 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF755 PF05501.6 ESA03229.1 - 1 9.3 9.8 0.25 11.3 4.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF4646 PF15496.1 ESA03230.1 - 0.0079 16.2 0.2 0.047 13.7 0.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4646) DivIC PF04977.10 ESA03231.1 - 0.56 9.7 5.4 0.25 10.8 1.2 2.1 1 1 1 2 2 2 0 Septum formation initiator ADIP PF11559.3 ESA03233.1 - 0.0039 17.1 3.3 0.0039 17.1 2.3 2.1 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding DivIC PF04977.10 ESA03233.1 - 0.017 14.6 1.2 0.017 14.6 0.8 2.6 2 1 1 3 3 3 0 Septum formation initiator HeLo PF14479.1 ESA03233.1 - 0.017 14.8 2.4 0.017 14.8 1.7 1.5 1 1 0 2 2 2 0 Prion-inhibition and propagation Ribosomal_L29 PF00831.18 ESA03233.1 - 0.1 12.3 0.4 0.1 12.3 0.3 2.0 3 0 0 3 3 3 0 Ribosomal L29 protein DUF342 PF03961.8 ESA03233.1 - 0.2 10.0 4.7 0.27 9.5 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) NAM-associated PF14303.1 ESA03233.1 - 0.51 10.6 8.3 0.099 12.9 2.8 1.8 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain DUF972 PF06156.8 ESA03233.1 - 0.73 10.2 7.6 0.6 10.4 3.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF972) CENP-Q PF13094.1 ESA03233.1 - 1.7 8.6 10.1 3.3 7.7 7.0 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit V_ATPase_I PF01496.14 ESA03233.1 - 2.7 5.7 6.9 3.2 5.5 4.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF465 PF04325.8 ESA03233.1 - 2.9 7.6 7.2 1.5 8.5 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF465) ATHILA PF03078.10 ESA03234.1 - 0.013 14.1 0.5 0.015 13.9 0.3 1.2 1 0 0 1 1 1 0 ATHILA ORF-1 family Gon7 PF08738.5 ESA03234.1 - 0.037 14.0 0.0 5.6 7.0 0.0 2.2 2 0 0 2 2 2 0 Gon7 family PhdYeFM_antitox PF02604.14 ESA03234.1 - 0.061 12.9 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system DnaB_bind PF10410.4 ESA03234.1 - 0.088 12.8 0.0 9.2 6.3 0.0 2.3 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase SpoIIID PF12116.3 ESA03234.1 - 0.12 12.3 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Stage III sporulation protein D bZIP_1 PF00170.16 ESA03235.1 - 3.4e-06 26.9 13.6 0.0056 16.6 1.2 3.1 2 1 1 3 3 3 2 bZIP transcription factor GAS PF13851.1 ESA03235.1 - 7.8e-06 25.2 15.7 9.5e-06 24.9 10.9 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding TSC22 PF01166.13 ESA03235.1 - 3.3e-05 23.7 14.8 0.11 12.5 2.2 3.4 1 1 2 3 3 3 2 TSC-22/dip/bun family DivIC PF04977.10 ESA03235.1 - 4.9e-05 22.7 19.1 0.037 13.4 3.0 3.3 1 1 2 3 3 3 3 Septum formation initiator bZIP_2 PF07716.10 ESA03235.1 - 0.00084 19.1 16.9 0.01 15.6 2.4 3.4 2 1 2 4 4 4 2 Basic region leucine zipper CENP-F_leu_zip PF10473.4 ESA03235.1 - 0.0014 18.5 15.3 0.0015 18.4 6.8 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Striatin PF08232.7 ESA03235.1 - 0.0015 18.8 15.4 0.0024 18.1 2.9 3.1 1 1 1 2 2 2 1 Striatin family Tup_N PF08581.5 ESA03235.1 - 0.0023 18.1 9.2 0.27 11.4 1.2 3.1 1 1 1 2 2 2 1 Tup N-terminal DLD PF14878.1 ESA03235.1 - 0.0051 16.9 7.4 0.0058 16.7 4.4 1.5 1 1 1 2 2 2 1 Death-like domain of SPT6 DUF1875 PF08961.5 ESA03235.1 - 0.0056 16.0 6.2 0.007 15.7 4.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1875) DUF972 PF06156.8 ESA03235.1 - 0.0091 16.3 14.6 0.97 9.8 1.9 2.9 1 1 1 2 2 2 1 Protein of unknown function (DUF972) Shugoshin_N PF07558.6 ESA03235.1 - 0.014 15.0 5.8 0.054 13.2 0.1 3.3 2 2 1 3 3 3 0 Shugoshin N-terminal coiled-coil region Atg14 PF10186.4 ESA03235.1 - 0.015 14.2 9.5 0.023 13.6 6.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF724 PF05266.9 ESA03235.1 - 0.018 14.6 11.9 0.026 14.1 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Phage_GP20 PF06810.6 ESA03235.1 - 0.019 14.4 12.8 0.15 11.4 4.9 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 MamL-1 PF09596.5 ESA03235.1 - 0.025 14.3 2.3 0.071 12.9 0.0 2.4 1 1 1 2 2 2 0 MamL-1 domain DUF904 PF06005.7 ESA03235.1 - 0.029 14.6 18.8 0.81 10.0 2.7 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Packaging_FI PF14000.1 ESA03235.1 - 0.035 14.3 9.5 0.17 12.1 1.7 2.2 1 1 1 2 2 2 0 DNA packaging protein FI IncA PF04156.9 ESA03235.1 - 0.035 13.6 12.4 0.052 13.1 8.6 1.3 1 0 0 1 1 1 0 IncA protein CCDC155 PF14662.1 ESA03235.1 - 0.041 13.4 13.0 0.058 12.9 9.0 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Mod_r PF07200.8 ESA03235.1 - 0.073 12.9 12.2 0.22 11.4 3.7 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CALCOCO1 PF07888.6 ESA03235.1 - 0.084 11.1 12.9 0.18 10.0 8.9 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6 PF04111.7 ESA03235.1 - 0.084 11.9 13.6 0.11 11.5 9.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF342 PF03961.8 ESA03235.1 - 0.086 11.2 8.7 0.1 10.9 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Nup54 PF13874.1 ESA03235.1 - 0.11 12.1 12.2 6 6.5 8.3 2.1 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 BBP1_C PF15272.1 ESA03235.1 - 0.15 11.5 10.5 0.33 10.4 7.3 1.5 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Fib_alpha PF08702.5 ESA03235.1 - 0.16 12.0 5.9 0.22 11.6 4.0 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Leu_zip PF15294.1 ESA03235.1 - 0.17 10.9 11.0 0.2 10.7 7.6 1.2 1 0 0 1 1 1 0 Leucine zipper TMF_DNA_bd PF12329.3 ESA03235.1 - 0.18 11.5 19.6 0.93 9.3 5.3 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding NPV_P10 PF05531.7 ESA03235.1 - 0.2 11.9 2.4 1.6 9.0 0.2 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.4 ESA03235.1 - 0.28 11.3 10.1 0.42 10.7 2.5 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.6 ESA03235.1 - 0.29 11.0 11.9 0.34 10.8 1.5 3.2 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) K-box PF01486.12 ESA03235.1 - 0.29 10.9 11.0 0.69 9.7 1.8 2.6 2 1 0 2 2 2 0 K-box region Spc7 PF08317.6 ESA03235.1 - 0.33 9.5 13.3 0.43 9.1 9.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein HlyD PF00529.15 ESA03235.1 - 0.34 10.1 6.9 0.38 9.9 4.8 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Nnf1 PF03980.9 ESA03235.1 - 0.38 10.7 12.3 3.7 7.5 1.8 3.0 2 1 1 3 3 3 0 Nnf1 DUF1465 PF07323.7 ESA03235.1 - 0.59 9.6 7.5 0.45 10.0 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) HAUS-augmin3 PF14932.1 ESA03235.1 - 0.61 9.2 10.6 0.74 8.9 7.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.3 ESA03235.1 - 0.63 9.9 14.8 0.96 9.3 4.3 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Acyl-CoA_dh_2 PF08028.6 ESA03235.1 - 0.65 10.2 4.3 0.81 9.9 3.0 1.2 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain DUF4140 PF13600.1 ESA03235.1 - 0.65 10.4 13.0 3.3 8.2 1.2 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2216 PF10226.4 ESA03235.1 - 0.71 9.3 9.0 0.19 11.2 0.6 2.4 1 1 2 3 3 3 0 Uncharacterized conserved proteins (DUF2216) DUF3373 PF11853.3 ESA03235.1 - 0.78 8.1 12.9 0.4 9.1 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3373) Seryl_tRNA_N PF02403.17 ESA03235.1 - 0.8 9.7 16.5 7.9 6.5 11.2 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TraC PF07820.7 ESA03235.1 - 0.8 9.9 11.2 1.5 9.0 7.4 1.8 1 1 1 2 2 2 0 TraC-like protein Mnd1 PF03962.10 ESA03235.1 - 1 8.9 15.1 2.5 7.7 2.8 2.0 1 1 1 2 2 2 0 Mnd1 family DUF2407_C PF13373.1 ESA03235.1 - 1 9.2 7.5 8.7 6.2 5.2 2.0 1 1 0 1 1 1 0 DUF2407 C-terminal domain BCAS2 PF05700.6 ESA03235.1 - 1.1 8.7 11.6 0.98 8.8 4.9 2.0 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Spc24 PF08286.6 ESA03235.1 - 1.2 8.8 13.8 2.8 7.6 3.3 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 HAUS6_N PF14661.1 ESA03235.1 - 1.2 8.3 9.4 1.9 7.8 6.5 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus NYD-SP28 PF14772.1 ESA03235.1 - 1.4 9.0 15.3 0.33 11.0 5.3 2.2 1 1 1 2 2 2 0 Sperm tail Cortex-I_coil PF09304.5 ESA03235.1 - 1.5 8.9 15.1 4.5 7.3 8.1 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil ATG16 PF08614.6 ESA03235.1 - 1.6 8.5 15.6 16 5.2 7.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4200 PF13863.1 ESA03235.1 - 1.7 8.6 20.4 24 4.8 14.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4201 PF13870.1 ESA03235.1 - 1.7 8.0 14.6 3 7.2 9.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF3251 PF11622.3 ESA03235.1 - 1.8 7.9 4.1 8.1 5.8 0.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3251) Prefoldin PF02996.12 ESA03235.1 - 1.9 8.1 12.4 0.74 9.4 1.8 2.8 1 1 1 2 2 2 0 Prefoldin subunit TMF_TATA_bd PF12325.3 ESA03235.1 - 2 8.1 15.2 9.1 6.0 6.7 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Snapin_Pallidin PF14712.1 ESA03235.1 - 2.1 8.7 7.0 0.97 9.7 2.3 2.0 1 1 1 2 2 2 0 Snapin/Pallidin CENP-Q PF13094.1 ESA03235.1 - 2.1 8.3 21.0 0.31 11.0 6.2 2.3 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit HALZ PF02183.13 ESA03235.1 - 2.6 7.8 12.4 2.4 7.9 0.8 3.4 1 1 3 4 4 3 0 Homeobox associated leucine zipper TMCO5 PF14992.1 ESA03235.1 - 3.1 6.8 11.5 3.8 6.5 7.9 1.2 1 0 0 1 1 1 0 TMCO5 family CASP_C PF08172.7 ESA03235.1 - 4 6.3 12.5 1.5 7.7 1.6 2.8 1 1 0 1 1 1 0 CASP C terminal Prefoldin_2 PF01920.15 ESA03235.1 - 4.4 7.1 13.8 28 4.5 9.6 2.2 1 1 0 1 1 1 0 Prefoldin subunit NYD-SP28_assoc PF14775.1 ESA03235.1 - 4.5 7.0 6.5 7.5 6.3 1.0 3.3 2 2 0 2 2 2 0 Sperm tail C-terminal domain DOG1 PF14144.1 ESA03235.1 - 4.6 7.3 5.1 4.3 7.4 0.5 2.6 1 1 2 3 3 3 0 Seed dormancy control DUF4398 PF14346.1 ESA03235.1 - 4.9 7.2 17.4 1.3 9.0 6.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) AAA_13 PF13166.1 ESA03235.1 - 5.2 5.3 16.1 8.1 4.7 11.2 1.3 1 1 0 1 1 1 0 AAA domain DUF244 PF03112.9 ESA03235.1 - 5.3 6.5 8.5 13 5.3 5.8 1.6 1 1 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF Ax_dynein_light PF10211.4 ESA03235.1 - 5.4 6.8 18.1 7 6.4 4.8 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain WD40_alt PF14077.1 ESA03235.1 - 5.4 6.7 8.3 7.6 6.2 0.2 3.2 2 1 1 3 3 3 0 Alternative WD40 repeat motif V_ATPase_I PF01496.14 ESA03235.1 - 5.6 4.6 8.3 6.5 4.4 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.1 ESA03235.1 - 6.5 6.5 18.1 11 5.7 5.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF641 PF04859.7 ESA03235.1 - 7.3 6.3 11.9 0.33 10.7 1.6 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) IFP_35_N PF07334.8 ESA03235.1 - 7.6 6.5 11.3 0.54 10.2 0.2 3.1 1 1 2 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus TMPIT PF07851.8 ESA03235.1 - 7.6 5.4 7.4 9.3 5.2 5.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein TSKS PF15358.1 ESA03237.1 - 0.0044 15.2 0.2 0.0052 15.0 0.1 1.1 1 0 0 1 1 1 1 Testis-specific serine kinase substrate Striatin PF08232.7 ESA03238.1 - 0.038 14.2 10.3 0.023 15.0 5.3 2.0 2 0 0 2 2 2 0 Striatin family DUF1465 PF07323.7 ESA03238.1 - 0.1 12.1 3.2 0.26 10.8 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) ETRAMP PF09716.5 ESA03238.1 - 0.33 10.9 1.8 0.59 10.1 0.2 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) bZIP_1 PF00170.16 ESA03238.1 - 0.49 10.3 9.2 0.047 13.6 1.5 2.9 3 0 0 3 3 3 0 bZIP transcription factor FAM219A PF15260.1 ESA03239.1 - 4.4 7.6 8.3 1.6 9.0 1.2 2.2 2 0 0 2 2 2 0 Protein family FAM219A Microtub_assoc PF07989.6 ESA03241.1 - 0.077 12.8 2.3 0.29 10.9 0.0 2.7 2 2 1 3 3 3 0 Microtubule associated DivIC PF04977.10 ESA03241.1 - 1.3 8.5 4.1 1 8.9 0.1 2.3 2 1 0 2 2 2 0 Septum formation initiator DUF2127 PF09900.4 ESA03244.1 - 0.055 13.5 0.0 0.069 13.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2127) DUF4351 PF14261.1 ESA03244.1 - 0.14 12.0 0.2 0.86 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4351) ORF6N PF10543.4 ESA03247.1 - 0.064 13.2 0.2 0.09 12.8 0.1 1.3 1 0 0 1 1 1 0 ORF6N domain ELO PF01151.13 ESA03248.1 - 4e-56 190.1 30.3 4.7e-56 189.8 21.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Mhr1 PF12829.2 ESA03249.1 - 3e-09 36.5 0.5 3.6e-07 29.9 0.0 2.4 1 1 1 2 2 2 2 Transcriptional regulation of mitochondrial recombination Dynamin_M PF01031.15 ESA03250.1 - 4.2e-13 48.7 0.3 9.4e-10 37.7 0.0 2.8 3 0 0 3 3 3 2 Dynamin central region Dynamin_N PF00350.18 ESA03250.1 - 1.6e-07 31.3 2.7 5.8e-07 29.4 0.0 2.7 2 1 0 2 2 2 1 Dynamin family GED PF02212.13 ESA03250.1 - 0.00066 19.5 4.3 0.0011 18.8 0.1 3.3 3 1 0 3 3 3 1 Dynamin GTPase effector domain DUF2856 PF11043.3 ESA03250.1 - 0.067 13.3 0.1 0.48 10.5 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2856) SRI PF08236.6 ESA03250.1 - 0.31 11.0 4.8 0.38 10.7 0.3 3.0 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain VanW PF04294.8 ESA03251.1 - 0.065 12.4 0.0 0.073 12.2 0.0 1.1 1 0 0 1 1 1 0 VanW like protein Biotin_lipoyl PF00364.17 ESA03252.1 - 0.016 14.8 0.0 0.84 9.3 0.0 2.3 2 0 0 2 2 2 0 Biotin-requiring enzyme TPK_catalytic PF04263.11 ESA03252.1 - 0.094 12.3 0.1 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain SRP_SPB PF02978.14 ESA03254.1 - 1.1 9.5 7.0 0.8 9.9 1.9 2.3 2 1 1 3 3 3 0 Signal peptide binding domain Chitin_synth_1 PF01644.12 ESA03258.1 - 2.1e-88 294.2 0.2 3.2e-88 293.6 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 ESA03258.1 - 1.5e-33 114.3 0.4 2.9e-33 113.3 0.3 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 ESA03258.1 - 1.3e-22 79.9 0.0 9.5e-19 67.1 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA03258.1 - 2.5e-07 30.5 6.6 2.5e-07 30.5 4.6 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA03258.1 - 1.3e-05 25.1 0.0 3.4e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 XPG_I PF00867.13 ESA03259.1 - 1.3e-27 95.7 0.0 4.7e-27 93.8 0.0 2.1 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 ESA03259.1 - 5e-15 55.5 0.1 3.5e-14 52.8 0.0 2.6 2 0 0 2 2 2 1 XPG N-terminal domain DBD_Tnp_Mut PF03108.10 ESA03260.1 - 6e-06 25.7 0.0 9e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 MuDR family transposase Spatacsin_C PF14649.1 ESA03261.1 - 0.063 12.1 0.3 0.095 11.5 0.2 1.2 1 0 0 1 1 1 0 Spatacsin C-terminus GAS PF13851.1 ESA03262.1 - 0.00055 19.1 12.7 0.00055 19.1 8.8 2.2 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.17 ESA03262.1 - 0.0029 17.6 9.1 0.0029 17.6 6.3 2.1 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain ADIP PF11559.3 ESA03262.1 - 0.0098 15.7 6.9 0.02 14.8 4.8 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DivIC PF04977.10 ESA03262.1 - 0.027 13.9 6.7 0.091 12.2 4.6 2.0 1 0 0 1 1 1 0 Septum formation initiator Fib_alpha PF08702.5 ESA03262.1 - 0.044 13.9 10.3 0.036 14.1 5.3 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family 5_nucleotid_C PF02872.13 ESA03262.1 - 0.046 13.6 1.1 2.3 8.1 0.1 2.5 2 1 0 2 2 2 0 5'-nucleotidase, C-terminal domain XhlA PF10779.4 ESA03262.1 - 0.063 13.1 10.1 0.18 11.7 6.6 2.2 1 1 0 1 1 1 0 Haemolysin XhlA DUF4140 PF13600.1 ESA03262.1 - 0.069 13.5 1.2 0.14 12.5 0.8 1.6 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF342 PF03961.8 ESA03262.1 - 0.14 10.5 9.2 0.06 11.7 3.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) SSFA2_C PF14723.1 ESA03262.1 - 0.21 11.2 1.5 0.89 9.2 0.3 2.3 2 1 0 2 2 2 0 Sperm-specific antigen 2 C-terminus IncA PF04156.9 ESA03262.1 - 0.32 10.5 6.7 0.69 9.4 4.6 1.5 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 ESA03262.1 - 0.37 10.7 7.5 0.67 9.8 5.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Lge1 PF11488.3 ESA03262.1 - 0.51 10.5 7.4 0.32 11.2 3.3 2.1 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 APG6 PF04111.7 ESA03262.1 - 0.57 9.1 13.8 0.04 12.9 6.0 1.6 2 0 0 2 2 2 0 Autophagy protein Apg6 Spc24 PF08286.6 ESA03262.1 - 0.68 9.6 9.4 1.9 8.1 6.5 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 HCaRG PF07258.9 ESA03262.1 - 0.75 9.3 7.1 8 5.9 0.0 2.6 2 1 0 2 2 2 0 HCaRG protein Atg14 PF10186.4 ESA03262.1 - 0.92 8.3 5.9 1.4 7.8 4.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TBPIP PF07106.8 ESA03262.1 - 1 8.8 14.5 0.24 10.9 7.1 2.1 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4337 PF14235.1 ESA03262.1 - 2 8.2 6.0 4.2 7.1 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4375 PF14300.1 ESA03262.1 - 9.8 6.1 11.5 0.13 12.2 2.4 2.0 3 0 0 3 3 2 0 Domain of unknown function (DUF4375) WD40 PF00400.27 ESA03263.1 - 1.6e-41 138.7 9.5 7.1e-07 28.8 0.3 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESA03263.1 - 3.8e-05 22.6 1.3 0.021 13.5 0.2 3.4 1 1 2 3 3 3 2 Nup133 N terminal like Nup160 PF11715.3 ESA03263.1 - 3.9e-05 21.9 1.1 0.063 11.4 0.0 3.7 3 2 1 4 4 4 2 Nucleoporin Nup120/160 PQQ_2 PF13360.1 ESA03263.1 - 0.0066 15.9 0.0 0.021 14.3 0.0 1.9 1 1 0 1 1 1 1 PQQ-like domain BBS2_Mid PF14783.1 ESA03263.1 - 0.036 13.8 0.2 2.5 7.9 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Sigma70_r1_2 PF00140.15 ESA03263.1 - 0.052 13.2 2.2 0.13 11.9 1.5 1.7 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 Amidase PF01425.16 ESA03264.1 - 5.3e-115 384.7 0.0 9.1e-115 383.9 0.0 1.4 1 1 0 1 1 1 1 Amidase DUF1372 PF07116.6 ESA03264.1 - 0.076 12.9 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1372) Prp18 PF02840.10 ESA03265.1 - 6.3e-53 178.5 0.5 6.3e-53 178.5 0.3 2.1 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.6 ESA03265.1 - 6.9e-12 44.4 1.6 1.5e-11 43.3 1.1 1.6 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Peptidase_C80 PF11713.3 ESA03265.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase C80 family ERAP1_C PF11838.3 ESA03265.1 - 0.073 12.3 1.4 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 ERAP1-like C-terminal domain DUF763 PF05559.6 ESA03265.1 - 1 8.2 7.9 1.3 7.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF763) DUF1542 PF07564.6 ESA03266.1 - 0.002 18.1 1.9 0.0036 17.2 1.3 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1542) Baculo_VP91_N PF08475.5 ESA03266.1 - 0.022 14.1 0.6 0.022 14.1 0.4 1.1 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal Pox_D3 PF04580.8 ESA03266.1 - 0.045 12.9 1.1 0.051 12.7 0.7 1.1 1 0 0 1 1 1 0 Chordopoxvirinae D3 protein adh_short PF00106.20 ESA03267.1 - 1.7e-14 54.1 0.0 2.6e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA03267.1 - 4.8e-09 36.3 0.0 5.9e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA03267.1 - 0.0004 20.0 0.0 0.00082 19.0 0.0 1.6 1 1 0 1 1 1 1 KR domain F-box-like PF12937.2 ESA03268.1 - 0.0016 18.1 1.4 0.0044 16.6 1.0 1.7 1 0 0 1 1 1 1 F-box-like adh_short PF00106.20 ESA03269.1 - 5.2e-21 75.2 0.0 7.1e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA03269.1 - 1.9e-07 30.9 0.0 4.2e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 ESA03269.1 - 6.7e-06 26.2 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 ESA03269.1 - 0.00092 18.2 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Eno-Rase_NADH_b PF12242.3 ESA03269.1 - 0.011 15.5 0.1 0.022 14.5 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.8 ESA03269.1 - 0.013 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.10 ESA03269.1 - 0.063 12.1 0.0 0.14 11.0 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Epimerase PF01370.16 ESA03269.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family HALZ PF02183.13 ESA03270.1 - 0.017 14.8 3.0 1.8 8.3 0.9 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF904 PF06005.7 ESA03270.1 - 0.019 15.2 11.2 0.41 10.9 7.8 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ESA03270.1 - 0.032 14.1 8.0 0.15 12.0 3.1 2.6 2 0 0 2 2 2 0 bZIP transcription factor DUF1548 PF07579.6 ESA03270.1 - 0.076 13.1 1.1 0.59 10.2 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) Ant_C PF05586.6 ESA03270.1 - 0.14 12.6 0.6 0.38 11.2 0.1 1.9 2 0 0 2 2 2 0 Anthrax receptor C-terminus region DivIC PF04977.10 ESA03270.1 - 0.19 11.2 10.1 2 7.9 2.5 2.9 2 1 1 3 3 3 0 Septum formation initiator DUF724 PF05266.9 ESA03270.1 - 1.4 8.5 10.2 0.22 11.1 3.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF972 PF06156.8 ESA03270.1 - 4.3 7.7 12.9 1.5 9.1 4.0 3.1 3 2 2 5 5 5 0 Protein of unknown function (DUF972) Mto2_bdg PF12808.2 ESA03270.1 - 5 7.3 7.7 4.9 7.3 0.0 3.1 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region M PF02370.11 ESA03270.1 - 9.4 6.9 12.1 8.9 7.0 0.2 4.2 2 1 1 3 3 3 0 M protein repeat DUF904 PF06005.7 ESA03271.1 - 1.9e-05 24.8 18.4 0.0096 16.1 7.2 3.0 1 1 1 2 2 2 2 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ESA03271.1 - 0.00018 21.3 21.5 0.0018 18.1 4.7 2.9 3 0 0 3 3 2 2 bZIP transcription factor DivIC PF04977.10 ESA03271.1 - 0.00041 19.7 21.5 0.017 14.6 1.0 3.1 2 1 1 3 3 3 2 Septum formation initiator DUF3166 PF11365.3 ESA03271.1 - 0.0062 16.9 6.4 0.16 12.4 0.1 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3166) CCDC155 PF14662.1 ESA03271.1 - 0.012 15.2 11.8 0.012 15.2 8.2 2.4 4 0 0 4 4 4 0 Coiled-coil region of CCDC155 HALZ PF02183.13 ESA03271.1 - 0.02 14.6 10.0 0.29 10.8 2.6 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 ESA03271.1 - 0.041 14.2 23.4 0.21 11.9 5.5 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF972) WXG100 PF06013.7 ESA03271.1 - 0.046 13.7 2.0 6 6.9 0.0 2.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG FlaC_arch PF05377.6 ESA03271.1 - 0.1 12.4 9.9 3.7 7.4 0.2 3.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) bZIP_2 PF07716.10 ESA03271.1 - 0.14 12.0 19.4 0.78 9.6 0.9 3.7 3 0 0 3 3 3 0 Basic region leucine zipper Ribosomal_L29 PF00831.18 ESA03271.1 - 0.15 11.7 0.2 0.15 11.7 0.1 2.9 2 0 0 2 2 2 0 Ribosomal L29 protein M PF02370.11 ESA03271.1 - 0.21 12.0 14.9 5.4 7.7 0.2 4.6 2 1 1 3 3 3 0 M protein repeat TSC22 PF01166.13 ESA03271.1 - 1.7 8.6 14.2 9.4 6.2 0.6 3.5 2 1 1 3 3 3 0 TSC-22/dip/bun family NYD-SP28_assoc PF14775.1 ESA03271.1 - 2.9 7.6 9.1 4.3 7.1 2.5 3.0 2 1 0 2 2 2 0 Sperm tail C-terminal domain DUF3186 PF11382.3 ESA03271.1 - 4.5 6.3 8.1 4.4 6.3 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3186) APG6 PF04111.7 ESA03271.1 - 5.9 5.8 21.3 0.2 10.6 8.5 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 Uds1 PF15456.1 ESA03272.1 - 0.13 12.2 4.5 0.19 11.6 3.1 1.3 1 0 0 1 1 1 0 Up-regulated During Septation DUF1957 PF09210.6 ESA03272.1 - 0.18 11.8 1.7 0.32 11.0 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) IncA PF04156.9 ESA03272.1 - 8.6 5.9 7.0 13 5.3 4.9 1.2 1 0 0 1 1 1 0 IncA protein Helicase_C PF00271.26 ESA03278.1 - 4.2e-09 36.1 0.0 6.1e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_4 PF13871.1 ESA03278.1 - 0.047 13.1 0.1 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Helicase_C-like P5CR_dimer PF14748.1 ESA03279.1 - 6.8e-36 122.5 1.4 1.2e-35 121.6 0.7 1.6 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 ESA03279.1 - 8.1e-14 51.8 1.0 2.3e-13 50.3 0.2 2.1 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.12 ESA03279.1 - 0.0018 17.1 0.1 0.003 16.4 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase NAC PF01849.13 ESA03280.1 - 1.1e-20 72.9 0.3 2.1e-20 71.9 0.2 1.6 1 0 0 1 1 1 1 NAC domain Ribosomal_60s PF00428.14 ESA03280.1 - 0.18 12.2 6.3 0.077 13.4 2.5 1.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Prenyltrans PF00432.16 ESA03281.1 - 5.8e-12 44.9 0.5 7.5e-06 25.4 0.0 2.4 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESA03281.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.6 1 1 0 1 1 1 0 Prenyltransferase-like FBA PF04300.8 ESA03282.1 - 0.71 9.8 6.2 10 6.0 0.0 2.9 1 1 1 3 3 3 0 F-box associated region DUF4419 PF14388.1 ESA03283.1 - 0.048 12.8 0.2 0.048 12.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4419) DUF4441 PF14536.1 ESA03283.1 - 0.16 11.9 2.9 0.17 11.8 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) TetR_C_4 PF08359.6 ESA03283.1 - 0.27 11.1 2.5 1.4 8.8 0.5 2.0 1 1 1 2 2 2 0 YsiA-like protein, C-terminal region Peptidase_C1_2 PF03051.10 ESA03286.1 - 9.7e-172 571.3 0.3 1.1e-171 571.1 0.2 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 ESA03286.1 - 1.2e-07 31.9 0.1 0.00026 20.9 0.1 2.3 2 0 0 2 2 2 2 Papain family cysteine protease CHORD PF04968.7 ESA03287.1 - 5e-54 180.4 16.2 7.6e-29 99.7 2.5 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.11 ESA03287.1 - 7.3e-18 64.9 2.3 1.4e-17 63.9 1.6 1.5 1 0 0 1 1 1 1 CS domain Y_phosphatase2 PF03162.8 ESA03288.1 - 9.1e-46 155.2 0.0 1.3e-45 154.7 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 ESA03288.1 - 5.8e-05 22.6 0.0 9.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA03288.1 - 0.00019 20.8 0.0 0.00028 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESA03288.1 - 0.022 15.0 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Phage_glycop_gL PF11108.3 ESA03288.1 - 0.035 14.0 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 Viral glycoprotein L RNase_T PF00929.19 ESA03289.1 - 6e-31 107.9 0.1 9.2e-31 107.3 0.1 1.2 1 0 0 1 1 1 1 Exonuclease DUF2757 PF10955.3 ESA03289.1 - 0.035 14.3 0.1 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) 2OG-FeII_Oxy_3 PF13640.1 ESA03290.1 - 4.8e-09 36.6 0.0 7.9e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 ESA03290.1 - 2.9e-06 26.7 0.0 5.6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.8 ESA03290.1 - 0.00032 19.5 0.0 0.00046 19.0 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein 2OG-FeII_Oxy PF03171.15 ESA03290.1 - 0.014 15.6 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily MMR_HSR1 PF01926.18 ESA03291.1 - 1.8e-09 37.5 0.1 1.8e-09 37.5 0.1 3.2 4 0 0 4 4 4 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA03291.1 - 3.6e-06 26.2 1.3 0.071 12.2 0.0 3.4 3 0 0 3 3 3 2 AIG1 family Septin PF00735.13 ESA03291.1 - 1.7e-05 23.9 2.7 5.8e-05 22.2 0.8 2.7 2 1 0 2 2 2 1 Septin DUF258 PF03193.11 ESA03291.1 - 4.7e-05 22.6 0.1 0.0002 20.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 ESA03291.1 - 0.00084 19.1 6.2 0.018 14.8 0.8 3.6 2 1 0 2 2 2 1 Dynamin family AAA_29 PF13555.1 ESA03291.1 - 0.00093 18.6 0.0 0.0028 17.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ESA03291.1 - 0.0063 15.9 0.1 0.02 14.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain T2SE PF00437.15 ESA03291.1 - 0.0094 14.8 0.0 0.019 13.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 ESA03291.1 - 0.015 15.2 0.1 0.12 12.3 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 ESA03291.1 - 0.018 14.5 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESA03291.1 - 0.056 13.5 0.1 0.36 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 ESA03291.1 - 0.079 12.1 1.6 0.35 10.0 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain HR1 PF02185.11 ESA03291.1 - 0.099 12.4 6.1 0.38 10.5 1.0 3.3 2 0 0 2 2 2 0 Hr1 repeat ABC_tran PF00005.22 ESA03291.1 - 0.11 12.8 0.0 0.11 12.8 0.0 3.3 4 0 0 4 4 4 0 ABC transporter eIF3_subunit PF08597.5 ESA03292.1 - 1.2 8.6 7.0 6.5 6.2 4.8 2.1 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit Pkinase PF00069.20 ESA03294.1 - 6.1e-35 120.6 0.0 7.6e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03294.1 - 3.1e-31 108.3 0.0 3.7e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA03294.1 - 3.9e-05 23.5 0.0 8.5e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA03294.1 - 0.0015 17.6 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA03294.1 - 0.0018 17.6 0.0 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA03294.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) LRR_4 PF12799.2 ESA03296.1 - 0.14 11.8 1.6 1.2 8.8 0.1 3.0 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.12 ESA03297.1 - 6e-06 25.5 0.3 9.7e-06 24.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03297.1 - 0.0032 16.6 0.1 0.015 14.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain DUF2252 PF10009.4 ESA03299.1 - 0.19 10.5 1.0 0.35 9.7 0.7 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Rep_4 PF05797.6 ESA03300.1 - 0.1 11.2 0.1 0.12 11.0 0.1 1.1 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) Pertus-S5-tox PF09276.5 ESA03300.1 - 0.12 12.3 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Pertussis toxin S5 subunit MAD PF05557.8 ESA03301.1 - 0.03 12.4 38.2 0.037 12.1 26.5 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Seryl_tRNA_N PF02403.17 ESA03301.1 - 0.041 13.9 49.1 1.6 8.7 13.6 3.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Reo_sigmaC PF04582.7 ESA03301.1 - 0.058 12.5 7.4 1.3 8.1 0.2 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF1664 PF07889.7 ESA03301.1 - 0.086 12.6 30.4 0.3 10.9 6.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF3053 PF11254.3 ESA03301.1 - 0.32 10.2 8.8 3.1 7.0 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3053) DUF1325 PF07039.6 ESA03301.1 - 0.7 9.5 7.1 0.13 11.8 2.3 1.7 1 1 1 2 2 2 0 SGF29 tudor-like domain Prefoldin_2 PF01920.15 ESA03301.1 - 1.1 9.0 50.1 0.095 12.4 5.3 4.0 2 1 1 3 3 2 0 Prefoldin subunit IncA PF04156.9 ESA03301.1 - 1.8 8.1 41.7 5.1e+03 -3.2 28.9 2.4 1 1 0 1 1 1 0 IncA protein KfrA_N PF11740.3 ESA03301.1 - 2.4 8.6 6.6 5.4 7.4 1.7 2.5 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term WXG100 PF06013.7 ESA03301.1 - 4.9 7.2 10.9 17 5.4 0.2 3.8 3 1 0 3 3 3 0 Proteins of 100 residues with WXG ATG16 PF08614.6 ESA03301.1 - 6 6.6 41.2 7.6 6.3 13.3 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) GAGA_bind PF06217.7 ESA03301.1 - 6 6.7 16.4 7.4 6.4 11.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4618 PF15397.1 ESA03301.1 - 6.1 6.1 42.9 3 7.1 18.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) SHOCT PF09851.4 ESA03303.1 - 0.17 11.4 1.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 Short C-terminal domain Pkinase_Tyr PF07714.12 ESA03305.1 - 1.8e-26 92.7 0.2 2.3e-26 92.4 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03305.1 - 4.3e-26 91.6 0.7 5e-26 91.4 0.5 1.0 1 0 0 1 1 1 1 Protein kinase domain ABC1 PF03109.11 ESA03305.1 - 0.018 15.0 0.1 0.053 13.5 0.1 1.9 1 1 0 1 1 1 0 ABC1 family F420_oxidored PF03807.12 ESA03305.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Docking PF08990.6 ESA03305.1 - 0.14 11.3 0.1 0.32 10.2 0.1 1.5 1 0 0 1 1 1 0 Erythronolide synthase docking Tetraspannin PF00335.15 ESA03306.1 - 0.061 12.5 1.8 0.072 12.3 1.2 1.0 1 0 0 1 1 1 0 Tetraspanin family Enterotoxin_b PF01376.13 ESA03306.1 - 0.088 12.6 0.2 0.11 12.4 0.1 1.3 1 1 0 1 1 1 0 Heat-labile enterotoxin beta chain Ag332 PF04671.7 ESA03307.1 - 0.16 11.7 13.0 1.7 8.5 0.9 3.2 1 1 1 3 3 3 0 Erythrocyte membrane-associated giant protein antigen 332 Ndc1_Nup PF09531.5 ESA03308.1 - 0.07 11.5 7.0 0.088 11.2 4.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Prefoldin_2 PF01920.15 ESA03308.1 - 5 6.9 7.9 10 5.9 1.9 2.7 2 1 0 2 2 2 0 Prefoldin subunit CTK3 PF12243.3 ESA03309.1 - 1.3e-26 92.8 0.3 2.9e-26 91.7 0.2 1.6 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.3 ESA03309.1 - 3.5e-12 46.1 2.5 3.5e-12 46.1 1.7 2.5 3 0 0 3 3 3 1 CTD kinase subunit gamma CTK3 C-terminus zf-H2C2_2 PF13465.1 ESA03310.1 - 1.6e-29 100.6 39.2 1.7e-09 37.4 1.4 6.5 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.21 ESA03310.1 - 2.2e-17 62.2 42.7 7.5e-05 22.8 1.0 8.1 8 0 0 8 8 8 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA03310.1 - 7.7e-12 44.6 47.1 0.00025 21.1 0.7 8.3 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA03310.1 - 5.8e-05 22.8 16.8 0.0067 16.2 0.2 6.3 6 0 0 6 6 6 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA03310.1 - 0.00013 21.9 10.0 0.0069 16.5 0.3 4.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA03310.1 - 0.0029 17.7 6.2 0.087 13.0 0.5 3.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type RRM_1 PF00076.17 ESA03311.1 - 2.1e-14 52.8 0.0 4.2e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03311.1 - 1.2e-08 34.8 0.0 2.5e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03311.1 - 4e-08 32.9 0.0 7.4e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF913 PF06025.7 ESA03312.1 - 0.16 10.7 3.5 0.16 10.6 2.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ribosomal_L35Ae PF01247.13 ESA03312.1 - 0.68 9.7 0.1 0.68 9.7 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L35Ae DUF1510 PF07423.6 ESA03312.1 - 0.81 9.0 21.4 0.7 9.2 14.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) RNase_H2-Ydr279 PF09468.5 ESA03312.1 - 0.82 8.7 16.6 0.9 8.6 11.5 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF1266 PF06889.6 ESA03312.1 - 3.4 7.4 5.9 16 5.2 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1266) DUF4557 PF15101.1 ESA03312.1 - 3.7 7.3 12.7 3.1 7.5 7.7 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4557) RVT_1 PF00078.22 ESA03313.1 - 0.00034 20.0 0.0 0.00053 19.4 0.0 1.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SpoVG PF04026.7 ESA03313.1 - 0.11 12.4 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 SpoVG DUF2417 PF10329.4 ESA03315.1 - 0.0084 15.5 0.5 0.0085 15.5 0.4 1.0 1 0 0 1 1 1 1 Region of unknown function (DUF2417) TcpE PF12648.2 ESA03315.1 - 0.041 14.0 0.9 0.052 13.7 0.6 1.1 1 0 0 1 1 1 0 TcpE family F-box-like PF12937.2 ESA03317.1 - 0.0024 17.5 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA03318.1 - 0.1 12.2 7.7 0.041 13.5 3.2 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA03318.1 - 2 8.7 6.0 4.2 7.7 0.3 3.3 3 0 0 3 3 3 0 Leucine Rich Repeat Cyclin PF08613.6 ESA03320.1 - 1.5e-11 44.9 0.0 6.2e-10 39.6 0.0 2.3 2 0 0 2 2 2 2 Cyclin Radical_SAM PF04055.16 ESA03321.1 - 6.7e-15 55.6 0.0 1.2e-14 54.8 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 ESA03321.1 - 0.00019 21.5 0.1 0.00038 20.5 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 ESA03321.1 - 0.0014 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain HemN_C PF06969.11 ESA03321.1 - 0.077 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 HemN C-terminal domain G-patch PF01585.18 ESA03322.1 - 6.5e-15 54.6 0.9 2e-14 53.1 0.6 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA03322.1 - 1.8e-08 34.1 0.2 1.8e-08 34.1 0.2 2.5 2 1 0 2 2 2 1 DExH-box splicing factor binding site DUF3860 PF12976.2 ESA03322.1 - 0.018 14.8 0.2 0.045 13.5 0.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) DUF4289 PF14121.1 ESA03322.1 - 0.11 10.9 3.2 0.14 10.5 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4289) Vfa1 PF08432.5 ESA03322.1 - 1.7 8.6 11.8 2.5 8.1 8.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ubiquitin PF00240.18 ESA03323.1 - 0.015 14.6 0.1 0.071 12.5 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin family AAA_17 PF13207.1 ESA03323.1 - 0.016 16.0 0.1 0.071 13.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.4 ESA03323.1 - 0.029 13.3 0.0 0.36 9.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 ESA03323.1 - 0.031 14.4 0.0 0.084 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA03323.1 - 0.067 13.3 0.2 0.48 10.6 0.0 2.6 3 1 0 3 3 3 0 RNA helicase AAA_25 PF13481.1 ESA03323.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain Pmp3 PF01679.12 ESA03324.1 - 5.7e-22 77.1 4.3 7.5e-22 76.7 3.0 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Collagen PF01391.13 ESA03324.1 - 0.017 14.6 4.2 0.028 13.9 2.9 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Pex14_N PF04695.8 ESA03324.1 - 2.7 8.0 8.0 3.9 7.5 5.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Alg6_Alg8 PF03155.10 ESA03325.1 - 4.3e-42 144.5 5.9 5.1e-42 144.3 4.1 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Acyltransferase PF01553.16 ESA03326.1 - 1.8e-10 40.3 0.1 4.5e-09 35.8 0.1 2.4 1 1 0 1 1 1 1 Acyltransferase DPPIV_N PF00930.16 ESA03327.1 - 6.1e-26 90.8 0.0 4e-24 84.8 0.0 2.2 2 0 0 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region YfaZ PF07437.6 ESA03327.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 YfaZ precursor Sel1 PF08238.7 ESA03329.1 - 3.2e-16 59.3 6.9 3.2e-08 33.9 0.1 3.0 3 0 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ESA03329.1 - 3.2e-06 27.2 4.1 0.034 14.6 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA03329.1 - 0.0042 17.7 0.5 0.027 15.1 0.1 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03329.1 - 0.019 14.6 5.2 0.067 12.8 3.4 2.2 1 1 1 2 2 2 0 TPR repeat TPR_19 PF14559.1 ESA03329.1 - 0.026 14.8 2.3 3.5 8.0 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat Phage_RpbA PF10789.4 ESA03329.1 - 0.13 12.1 0.7 0.28 11.0 0.5 1.6 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA TPR_2 PF07719.12 ESA03329.1 - 0.58 10.2 6.9 2.8 8.0 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat CTP_transf_2 PF01467.21 ESA03330.1 - 0.094 12.7 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase Pkinase PF00069.20 ESA03331.1 - 2.2e-22 79.4 0.0 2.4e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03331.1 - 1.3e-18 67.0 0.0 1.4e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA03331.1 - 0.0025 17.5 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA03332.1 - 3.7e-40 137.6 0.2 7.1e-40 136.7 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03332.1 - 5e-33 114.3 0.4 5e-33 114.3 0.3 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA03332.1 - 4.3e-14 52.6 7.3 7.5e-07 29.5 0.3 2.7 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.1 ESA03332.1 - 0.00064 20.0 5.3 0.23 12.0 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA03332.1 - 0.0052 17.4 0.2 0.018 15.6 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TRA-1_regulated PF02343.11 ESA03332.1 - 0.043 13.3 0.0 0.099 12.1 0.0 1.6 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 TPR_19 PF14559.1 ESA03332.1 - 0.24 11.7 2.0 11 6.4 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF1218 PF06749.7 ESA03333.1 - 0.16 12.4 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) Pkinase PF00069.20 ESA03337.1 - 1.9e-41 141.9 1.2 1.9e-41 141.9 0.8 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03337.1 - 2e-41 141.7 0.0 2.8e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-CCHC PF00098.18 ESA03338.1 - 4.5e-07 29.4 0.5 6.8e-07 28.9 0.3 1.3 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 ESA03338.1 - 0.0018 18.3 0.7 0.025 14.6 0.0 2.8 3 1 0 3 3 3 1 Retrotransposon gag protein zf-CCHC_6 PF15288.1 ESA03338.1 - 0.0051 16.4 0.2 0.011 15.4 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle ROS_MUCR PF05443.6 ESA03338.1 - 0.017 14.9 0.4 0.046 13.5 0.0 1.9 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Nic96 PF04097.9 ESA03338.1 - 0.026 12.6 0.5 0.035 12.2 0.3 1.1 1 0 0 1 1 1 0 Nup93/Nic96 eIF3g PF12353.3 ESA03338.1 - 0.063 13.1 0.6 0.16 11.8 0.4 1.7 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G UBN2 PF14223.1 ESA03338.1 - 0.11 12.2 0.0 0.39 10.5 0.0 1.9 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type Syntaxin_2 PF14523.1 ESA03338.1 - 0.56 10.2 4.8 0.45 10.5 0.3 2.6 3 0 0 3 3 3 0 Syntaxin-like protein RVP_2 PF08284.6 ESA03339.1 - 8.9e-11 41.8 0.0 1.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA03339.1 - 3e-06 26.7 0.0 5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESA03339.1 - 1.1e-05 25.7 0.0 1.9e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA03339.1 - 0.00012 21.8 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease PMBR PF09373.5 ESA03342.1 - 0.14 12.1 0.0 29 4.8 0.0 2.6 2 0 0 2 2 2 0 Pseudomurein-binding repeat DUF3385 PF11865.3 ESA03345.1 - 0.0087 16.0 0.0 5.2 6.9 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3385) DUF3800 PF12686.2 ESA03346.1 - 0.011 15.3 0.2 0.016 14.8 0.0 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3800) CPSase_L_D3 PF02787.14 ESA03349.1 - 0.041 13.6 0.1 0.043 13.5 0.0 1.0 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain PLU-1 PF08429.6 ESA03349.1 - 0.099 11.5 0.0 0.1 11.4 0.0 1.0 1 0 0 1 1 1 0 PLU-1-like protein HMG_box PF00505.14 ESA03351.1 - 1.5e-05 25.1 1.0 2.3e-05 24.5 0.7 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA03351.1 - 0.014 15.7 0.7 0.02 15.2 0.5 1.2 1 0 0 1 1 1 0 HMG-box domain MAT_Alpha1 PF04769.7 ESA03351.1 - 0.067 12.5 0.9 0.075 12.3 0.6 1.1 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 Yopt PF09467.5 ESA03354.1 - 0.00046 19.9 0.2 0.00072 19.3 0.1 1.2 1 0 0 1 1 1 1 Hypothetical protein Yopt HK97-gp10_like PF04883.7 ESA03354.1 - 0.022 15.6 1.0 0.37 11.7 0.7 2.0 1 1 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component Exonuc_VII_L PF02601.10 ESA03354.1 - 0.049 12.8 0.4 0.054 12.6 0.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ribosomal_L32e PF01655.13 ESA03354.1 - 0.081 12.9 0.3 0.092 12.8 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein L32 LSM PF01423.17 ESA03355.1 - 1.5e-20 72.4 0.0 2e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESA03355.1 - 0.0033 17.3 0.0 0.0037 17.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain PH PF00169.24 ESA03356.1 - 9.3e-38 128.6 14.1 7.2e-22 77.5 2.1 2.7 3 0 0 3 3 3 2 PH domain PH_11 PF15413.1 ESA03356.1 - 4.2e-20 72.0 20.4 5.3e-11 42.7 1.2 3.9 3 2 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.1 ESA03356.1 - 9.6e-13 47.9 12.1 2.8e-08 33.5 3.0 2.4 2 0 0 2 2 2 2 PH domain PH_8 PF15409.1 ESA03356.1 - 1e-10 41.5 7.0 1.3e-07 31.5 2.7 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.1 ESA03356.1 - 5.4e-07 29.7 12.1 3.1e-05 24.0 3.4 3.5 2 2 0 2 2 2 2 Pleckstrin homology domain PH_4 PF15404.1 ESA03356.1 - 2.6e-05 23.8 3.5 0.64 9.5 0.1 3.5 2 1 1 3 3 3 3 Pleckstrin homology domain Mcp5_PH PF12814.2 ESA03356.1 - 0.00059 19.7 8.1 0.25 11.2 1.6 2.7 2 1 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_6 PF15406.1 ESA03356.1 - 0.0047 16.9 0.0 1.6 8.8 0.0 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4054 PF13262.1 ESA03356.1 - 0.04 14.1 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) PBP1_TM PF14812.1 ESA03356.1 - 0.074 13.3 9.6 0.76 10.1 0.5 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PH_7 PF15408.1 ESA03356.1 - 0.11 12.3 1.6 0.31 10.9 0.2 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain SRR1 PF07985.7 ESA03357.1 - 6.8e-16 57.9 0.1 1.2e-15 57.1 0.1 1.4 1 0 0 1 1 1 1 SRR1 DUF2372 PF10178.4 ESA03358.1 - 2.1e-10 40.5 0.4 2e-09 37.4 0.1 2.0 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2372) Vps55 PF04133.9 ESA03360.1 - 0.0092 15.7 3.6 0.8 9.4 0.1 2.9 2 1 0 2 2 2 2 Vacuolar protein sorting 55 DUF3611 PF12263.3 ESA03360.1 - 0.2 11.0 0.1 0.2 11.0 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3611) DUF4117 PF13491.1 ESA03360.1 - 0.73 9.2 11.2 4.4 6.7 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4117) DUF1301 PF06979.7 ESA03361.1 - 0.034 14.3 0.4 0.053 13.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1301) DUF2207 PF09972.4 ESA03361.1 - 0.081 11.4 2.1 0.1 11.1 1.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Zip PF02535.17 ESA03362.1 - 3.9e-60 203.5 15.5 5e-60 203.1 10.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DDE_Tnp_IS1595 PF12762.2 ESA03367.1 - 0.025 14.4 0.1 0.041 13.7 0.1 1.4 1 0 0 1 1 1 0 ISXO2-like transposase domain DUF1688 PF07958.6 ESA03367.1 - 0.036 12.6 0.3 0.04 12.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) Prominin PF05478.6 ESA03367.1 - 0.15 9.5 7.6 0.16 9.4 5.3 1.0 1 0 0 1 1 1 0 Prominin DUF1635 PF07795.6 ESA03367.1 - 0.38 10.1 6.0 0.1 11.9 2.2 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) DUF2454 PF10521.4 ESA03368.1 - 0.0042 16.1 0.2 0.0061 15.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) DivIC PF04977.10 ESA03368.1 - 0.0049 16.3 2.3 0.013 15.0 1.6 1.7 1 0 0 1 1 1 1 Septum formation initiator DUF904 PF06005.7 ESA03368.1 - 0.026 14.7 1.9 0.026 14.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Anti-adapt_IraP PF10796.4 ESA03368.1 - 0.063 13.6 3.2 0.13 12.6 2.2 1.5 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein ADIP PF11559.3 ESA03368.1 - 0.13 12.1 7.2 0.042 13.7 1.9 2.2 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 ESA03368.1 - 0.45 10.0 8.2 0.26 10.8 2.0 2.1 2 1 0 2 2 2 0 IncA protein Striatin PF08232.7 ESA03368.1 - 1.3 9.3 9.1 13 6.1 6.4 2.6 1 1 1 2 2 2 0 Striatin family RESP18 PF14948.1 ESA03369.1 - 0.1 12.6 0.1 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 RESP18 domain Diphthamide_syn PF01866.12 ESA03370.1 - 8.7e-74 248.5 0.8 1.2e-73 248.0 0.6 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Ribosomal_L23eN PF03939.8 ESA03371.1 - 2.5e-20 72.2 14.0 2.5e-20 72.2 9.7 2.2 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.15 ESA03371.1 - 5.4e-20 71.1 4.0 1.2e-19 70.0 2.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 SRPRB PF09439.5 ESA03371.1 - 0.03 13.5 0.7 0.038 13.1 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Pex14_N PF04695.8 ESA03372.1 - 2e-19 70.0 0.0 2e-19 70.0 0.0 3.5 3 1 1 4 4 4 1 Peroxisomal membrane anchor protein (Pex14p) conserved region LepA_C PF06421.7 ESA03372.1 - 0.018 14.9 1.2 0.036 13.9 0.9 1.4 1 0 0 1 1 1 0 GTP-binding protein LepA C-terminus eIF3_N PF09440.5 ESA03372.1 - 0.3 11.2 4.6 1.8 8.7 2.2 2.3 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain T4-Gluco-transf PF09198.5 ESA03373.1 - 0.32 10.3 3.4 0.78 9.1 2.3 1.8 1 0 0 1 1 1 0 Bacteriophage T4 beta-glucosyltransferase GDI PF00996.13 ESA03374.1 - 7.8e-84 281.5 3.7 2.7e-83 279.7 2.6 1.7 1 1 0 1 1 1 1 GDP dissociation inhibitor Ribosomal_L22e PF01776.12 ESA03374.1 - 0.018 15.0 0.1 0.047 13.7 0.1 1.7 1 0 0 1 1 1 0 Ribosomal L22e protein family NUDIX_2 PF13869.1 ESA03375.1 - 4.9e-84 280.3 0.1 5.6e-84 280.1 0.1 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase Fcf1 PF04900.7 ESA03376.1 - 5.9e-22 77.6 0.3 1.7e-21 76.1 0.0 1.8 2 0 0 2 2 2 1 Fcf1 TFIID_30kDa PF03540.8 ESA03377.1 - 4.9e-26 90.2 0.1 6.8e-26 89.8 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.8 ESA03377.1 - 0.021 14.5 0.1 5.1 6.9 0.0 2.2 1 1 1 2 2 2 0 Bromodomain associated RRM_1 PF00076.17 ESA03378.1 - 3.3e-07 29.8 0.0 2.9e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03378.1 - 7e-06 25.9 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03378.1 - 0.0045 16.8 0.0 0.0082 15.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exo_endo_phos PF03372.18 ESA03380.1 - 2.9e-09 37.2 0.1 4.6e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA03380.1 - 0.00013 21.5 2.3 0.0002 20.9 0.5 2.3 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase MHCassoc_trimer PF08831.5 ESA03382.1 - 0.069 13.0 0.7 0.14 12.0 0.2 1.8 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain DUF1156 PF06634.7 ESA03383.1 - 0.099 12.4 0.3 0.14 11.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) ABC_membrane PF00664.18 ESA03384.1 - 2.4e-105 351.8 41.6 1.3e-59 201.8 11.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA03384.1 - 3.7e-68 228.0 3.5 1.6e-34 119.1 0.0 3.0 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.14 ESA03384.1 - 2.8e-17 62.7 9.8 6.7e-08 32.0 0.0 4.9 4 1 1 5 5 5 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 ESA03384.1 - 2e-10 39.8 2.6 7.3e-05 21.5 0.1 3.6 3 1 0 3 3 3 2 Predicted ATPase of the ABC class AAA_21 PF13304.1 ESA03384.1 - 3.2e-10 40.4 19.5 0.0013 18.7 0.0 6.3 4 2 0 4 4 4 2 AAA domain AAA_16 PF13191.1 ESA03384.1 - 2.4e-09 37.4 0.1 0.0029 17.6 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 ESA03384.1 - 3.3e-09 36.1 2.4 0.0015 18.0 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ESA03384.1 - 4.3e-09 35.7 0.4 0.00076 18.6 0.0 2.9 3 0 0 3 3 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA03384.1 - 2.5e-07 31.5 2.1 0.024 15.4 0.0 3.2 3 0 0 3 3 2 2 AAA domain SbcCD_C PF13558.1 ESA03384.1 - 4.2e-05 23.3 3.4 0.092 12.6 0.1 4.1 3 2 0 3 3 2 2 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.1 ESA03384.1 - 6.1e-05 22.6 0.1 0.22 11.2 0.0 3.2 3 0 0 3 3 3 2 Part of AAA domain MobB PF03205.9 ESA03384.1 - 0.00012 21.7 0.3 0.087 12.5 0.0 3.0 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 ESA03384.1 - 0.00013 21.1 0.3 1.5 7.8 0.0 3.5 3 0 0 3 3 3 1 Zeta toxin AAA_30 PF13604.1 ESA03384.1 - 0.00017 21.2 1.7 0.39 10.2 0.6 3.7 3 1 0 3 3 3 1 AAA domain DUF815 PF05673.8 ESA03384.1 - 0.00026 20.0 0.0 0.16 10.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_33 PF13671.1 ESA03384.1 - 0.00068 19.5 0.2 0.84 9.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.12 ESA03384.1 - 0.00089 19.1 0.2 0.01 15.6 0.0 3.8 5 0 0 5 5 4 2 Domain of unknown function DUF87 AAA_10 PF12846.2 ESA03384.1 - 0.001 18.6 2.2 1.2 8.4 0.0 4.3 5 0 0 5 5 5 1 AAA-like domain AAA_5 PF07728.9 ESA03384.1 - 0.0012 18.6 0.1 1.9 8.2 0.0 2.9 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESA03384.1 - 0.0014 18.8 6.4 0.58 10.3 0.5 4.0 2 2 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 ESA03384.1 - 0.0026 17.2 0.1 1.5 8.2 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family SRP54 PF00448.17 ESA03384.1 - 0.0029 17.0 0.0 0.54 9.6 0.0 2.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_18 PF13238.1 ESA03384.1 - 0.0057 16.9 8.8 0.64 10.3 0.0 4.0 4 0 0 4 4 4 2 AAA domain AAA_25 PF13481.1 ESA03384.1 - 0.009 15.4 0.4 4 6.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain CbiA PF01656.18 ESA03384.1 - 0.011 15.1 1.1 0.13 11.6 0.0 2.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.18 ESA03384.1 - 0.021 14.8 5.2 0.39 10.6 0.1 3.3 3 1 0 3 3 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 ESA03384.1 - 0.026 14.6 0.0 4.6 7.4 0.0 3.0 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.15 ESA03384.1 - 0.029 14.0 0.0 9.4 5.8 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_28 PF13521.1 ESA03384.1 - 0.055 13.4 0.1 13 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESA03384.1 - 0.12 12.2 7.2 3 7.7 0.0 4.7 3 2 1 5 5 5 0 AAA domain DUF3987 PF13148.1 ESA03384.1 - 2.4 6.6 0.0 2.4 6.6 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3987) DUF4339 PF14237.1 ESA03385.1 - 0.039 13.5 0.0 5.6 6.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4339) FYVE PF01363.16 ESA03385.1 - 0.082 12.8 2.8 0.14 12.0 0.3 2.3 2 0 0 2 2 2 0 FYVE zinc finger Invas_SpaK PF03519.9 ESA03386.1 - 0.11 12.3 0.3 0.42 10.4 0.0 2.0 2 0 0 2 2 2 0 Invasion protein B family LRAT PF04970.8 ESA03387.1 - 6e-14 52.0 0.1 1.5e-13 50.8 0.0 1.7 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.9 ESA03387.1 - 7.3e-06 25.8 0.2 2e-05 24.4 0.1 1.8 1 1 0 1 1 1 1 PPPDE putative peptidase domain Cyc-maltodext_C PF10438.4 ESA03391.1 - 0.017 15.1 1.2 0.024 14.6 0.1 1.8 2 0 0 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain WG_beta_rep PF14903.1 ESA03391.1 - 0.084 13.1 2.6 0.58 10.4 0.1 2.5 2 0 0 2 2 2 0 WG containing repeat HMG_box PF00505.14 ESA03392.1 - 0.0053 17.0 0.7 0.0081 16.4 0.5 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box AKAP95 PF04988.7 ESA03393.1 - 0.011 15.4 0.6 0.017 14.8 0.4 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) zf-U1 PF06220.7 ESA03393.1 - 0.14 11.7 1.7 0.34 10.4 1.2 1.7 1 0 0 1 1 1 0 U1 zinc finger Sel1 PF08238.7 ESA03394.1 - 2.8e-141 456.8 64.7 5.7e-12 45.8 0.5 13.1 13 0 0 13 13 13 13 Sel1 repeat Aurora-A_bind PF09041.5 ESA03394.1 - 2.6e-06 27.0 1.7 1.3 8.8 0.0 6.0 6 0 0 6 6 6 2 Aurora-A binding TPR_6 PF13174.1 ESA03394.1 - 0.092 13.2 27.6 3.7 8.2 0.0 9.0 11 1 0 11 11 11 0 Tetratricopeptide repeat MIT PF04212.13 ESA03394.1 - 2.8 7.9 42.4 7.3 6.5 0.1 10.8 9 2 4 13 13 13 0 MIT (microtubule interacting and transport) domain VSG_B PF13206.1 ESA03395.1 - 0.033 13.3 6.0 0.038 13.1 4.1 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain MCD PF05292.6 ESA03395.1 - 0.088 11.4 1.8 0.12 11.0 1.3 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase (MCD) OmpH PF03938.9 ESA03395.1 - 0.13 12.1 5.2 0.16 11.8 3.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Spt5_N PF11942.3 ESA03395.1 - 0.17 12.4 6.9 0.092 13.3 3.4 1.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal TPR_1 PF00515.23 ESA03395.1 - 0.2 11.3 4.3 0.5 10.0 0.2 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat BSMAP PF12280.3 ESA03395.1 - 0.26 11.1 3.8 0.3 10.9 2.6 1.2 1 0 0 1 1 1 0 Brain specific membrane anchored protein ATP-synt_B PF00430.13 ESA03395.1 - 0.29 10.9 6.0 0.41 10.4 4.2 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF3465 PF11948.3 ESA03395.1 - 0.38 10.5 2.6 0.57 9.9 1.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3465) ATP-synt_DE PF00401.15 ESA03395.1 - 0.45 10.4 6.7 0.11 12.4 2.1 1.9 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Fib_alpha PF08702.5 ESA03395.1 - 1.2 9.3 6.4 1.5 8.9 4.4 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family IncA PF04156.9 ESA03395.1 - 1.4 8.4 5.9 1.9 8.0 4.1 1.2 1 0 0 1 1 1 0 IncA protein Pkinase_Tyr PF07714.12 ESA03396.1 - 2e-48 164.7 0.0 3e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03396.1 - 1.6e-46 158.6 0.2 3.8e-46 157.3 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA03396.1 - 0.15 11.7 2.6 0.26 10.9 1.8 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA03397.1 - 1.2e-43 149.1 1.6 1.2e-43 149.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03397.1 - 1.7e-41 141.9 0.0 3.6e-41 140.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA03397.1 - 7.4e-17 61.3 8.1 8.4e-08 32.6 1.3 4.5 3 1 0 3 3 3 3 Sel1 repeat RIO1 PF01163.17 ESA03397.1 - 0.00079 18.8 0.2 0.0025 17.1 0.0 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA03397.1 - 0.0061 15.6 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA03397.1 - 0.13 11.9 0.1 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA03398.1 - 1.3e-16 60.4 0.0 1.8e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03398.1 - 9.7e-16 57.6 0.8 1.6e-15 56.9 0.1 1.7 2 1 0 2 2 2 1 Protein kinase domain Cript PF10235.4 ESA03398.1 - 0.37 11.1 4.4 0.9 9.9 3.1 1.6 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Ima1_N PF09779.4 ESA03401.1 - 0.017 15.6 0.1 0.022 15.2 0.1 1.2 1 0 0 1 1 1 0 Ima1 N-terminal domain DCR PF14047.1 ESA03401.1 - 0.044 14.0 1.5 0.052 13.8 0.2 1.7 2 0 0 2 2 2 0 Dppa2/4 conserved region Cys_rich_CPCC PF14206.1 ESA03401.1 - 0.069 12.7 0.1 0.08 12.5 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich CPCC DUF1542 PF07564.6 ESA03406.1 - 0.00046 20.1 3.9 0.00083 19.3 2.7 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA03406.1 - 0.026 14.3 0.4 0.037 13.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 HAUS4 PF14735.1 ESA03406.1 - 0.094 12.0 0.6 0.14 11.4 0.4 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 4 MoaC PF01967.16 ESA03407.1 - 0.0075 15.9 0.3 0.0094 15.6 0.2 1.1 1 0 0 1 1 1 1 MoaC family ComGG PF14173.1 ESA03407.1 - 0.061 13.5 1.7 0.084 13.0 1.0 1.3 1 1 0 1 1 1 0 ComG operon protein 7 Tox-REase-2 PF15646.1 ESA03407.1 - 0.33 10.8 3.7 0.36 10.7 2.6 1.0 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 Med9 PF07544.8 ESA03407.1 - 0.49 10.1 4.5 1.5 8.6 3.1 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Bud13 PF09736.4 ESA03407.1 - 0.54 10.5 8.5 0.62 10.3 5.9 1.0 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Lipocalin_6 PF13944.1 ESA03407.1 - 0.59 10.2 3.0 0.66 10.1 2.1 1.1 1 0 0 1 1 1 0 Lipocalin-like domain DUF241 PF03087.9 ESA03407.1 - 1.1 8.6 8.9 1.4 8.3 6.2 1.0 1 0 0 1 1 1 0 Arabidopsis protein of unknown function HMG14_17 PF01101.13 ESA03407.1 - 1.8 9.2 6.1 2.1 9.0 4.3 1.2 1 0 0 1 1 1 0 HMG14 and HMG17 WD40 PF00400.27 ESA03408.1 - 1.3e-37 126.2 8.4 1.2e-09 37.6 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 ESA03408.1 - 7e-08 32.4 0.1 0.23 11.1 0.0 3.5 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PCI PF01399.22 ESA03409.1 - 3e-10 40.3 0.8 3e-10 40.3 0.6 2.1 3 0 0 3 3 3 1 PCI domain DUF3336 PF11815.3 ESA03409.1 - 0.029 13.8 1.6 0.39 10.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3336) DUF745 PF05335.8 ESA03409.1 - 0.069 12.6 3.1 0.12 11.9 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Actin PF00022.14 ESA03410.1 - 1.2e-36 126.0 0.0 2.2e-20 72.4 0.0 2.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.8 ESA03410.1 - 2.1e-05 23.2 0.0 0.023 13.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein PPP5 PF08321.7 ESA03411.1 - 0.028 14.4 0.9 0.052 13.5 0.5 1.5 1 1 0 1 1 1 0 PPP5 TPR repeat region RsbU_N PF08673.5 ESA03411.1 - 0.06 13.3 0.2 0.55 10.2 0.0 2.4 2 1 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain SHS2_FTSA PF02491.15 ESA03411.1 - 0.068 13.0 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 SHS2 domain inserted in FTSA ASL_C PF08328.6 ESA03411.1 - 0.11 12.3 0.3 0.28 11.0 0.1 1.7 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminal zf-CCCH_2 PF14608.1 ESA03412.1 - 2.3e-10 40.0 76.4 0.003 17.4 2.8 7.5 7 1 0 7 7 7 6 Zinc finger C-x8-C-x5-C-x3-H type Metallophos_3 PF14582.1 ESA03413.1 - 0.00068 18.8 0.0 0.0008 18.6 0.0 1.2 1 0 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily Metallophos PF00149.23 ESA03414.1 - 5.8e-12 45.4 0.1 5.8e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA03414.1 - 2.4e-11 43.6 0.0 2.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.1 ESA03414.1 - 0.03 13.4 0.8 1.2 8.1 0.1 2.6 2 1 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Gp_dh_C PF02800.15 ESA03415.1 - 5.9e-74 246.7 0.1 7.7e-74 246.3 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESA03415.1 - 2e-59 199.9 0.0 3.8e-59 198.9 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 ESA03415.1 - 0.0013 18.6 0.1 0.032 14.1 0.0 2.7 3 0 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus Iso_dh PF00180.15 ESA03417.1 - 6.3e-98 327.9 0.0 7.3e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF2587 PF10759.4 ESA03417.1 - 0.18 11.2 0.0 0.37 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) SHQ1 PF04925.10 ESA03418.1 - 0.098 12.0 0.9 0.12 11.8 0.6 1.1 1 0 0 1 1 1 0 SHQ1 protein PIGA PF08288.7 ESA03418.1 - 0.27 11.5 3.1 0.28 11.5 1.1 1.7 2 0 0 2 2 2 0 PIGA (GPI anchor biosynthesis) CD34_antigen PF06365.7 ESA03419.1 - 0.033 13.8 0.2 0.041 13.5 0.1 1.3 1 1 0 1 1 1 0 CD34/Podocalyxin family EpsG PF14897.1 ESA03419.1 - 0.05 12.5 0.3 0.052 12.4 0.2 1.0 1 0 0 1 1 1 0 EpsG family Herpes_gE PF02480.11 ESA03419.1 - 0.056 11.7 0.0 0.064 11.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Protocadherin PF08374.6 ESA03419.1 - 0.071 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protocadherin Shisa PF13908.1 ESA03419.1 - 0.072 13.2 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator FAM163 PF15069.1 ESA03419.1 - 1.2 9.6 3.9 2 8.9 2.7 1.3 1 0 0 1 1 1 0 FAM163 family p450 PF00067.17 ESA03420.1 - 2.9e-37 128.2 0.0 3.2e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 RE_SinI PF09570.5 ESA03420.1 - 0.077 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 SinI restriction endonuclease Pkinase_Tyr PF07714.12 ESA03421.1 - 8.3e-32 110.2 0.0 1.2e-31 109.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03421.1 - 1.6e-30 106.1 0.0 2.5e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA03421.1 - 0.0063 16.2 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Stc1 PF12898.2 ESA03421.1 - 0.034 14.2 2.6 0.069 13.2 1.8 1.5 1 0 0 1 1 1 0 Stc1 domain TMEM219 PF14940.1 ESA03421.1 - 0.039 13.0 0.0 0.065 12.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane 219 PsbU PF06514.6 ESA03421.1 - 0.13 12.1 0.1 0.49 10.2 0.0 1.9 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) Cation_efflux PF01545.16 ESA03423.1 - 7.9e-29 100.6 4.1 1.2e-28 100.0 2.8 1.3 1 0 0 1 1 1 1 Cation efflux family APC10 PF03256.11 ESA03424.1 - 1.2e-59 201.2 0.1 1.4e-59 200.9 0.1 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.8 ESA03424.1 - 0.042 13.6 0.1 0.097 12.4 0.0 1.6 1 1 0 1 1 1 0 PITH domain TRAM_LAG1_CLN8 PF03798.11 ESA03425.1 - 5e-18 65.3 32.4 5e-18 65.3 22.4 1.4 2 0 0 2 2 2 1 TLC domain Xpo1 PF08389.7 ESA03425.1 - 0.093 12.6 0.6 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Exportin 1-like protein gpUL132 PF11359.3 ESA03430.1 - 0.053 12.8 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein UL132 F-box-like PF12937.2 ESA03431.1 - 0.00012 21.7 0.8 0.00047 19.8 0.5 2.1 2 0 0 2 2 2 1 F-box-like NRDD PF13597.1 ESA03431.1 - 0.004 15.2 1.0 0.0052 14.9 0.7 1.3 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase F-box PF00646.28 ESA03431.1 - 0.053 13.2 0.9 0.39 10.4 0.1 2.6 2 0 0 2 2 2 0 F-box domain Pentapeptide_4 PF13599.1 ESA03433.1 - 0.0062 16.3 0.8 0.0062 16.3 0.6 2.3 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) LRR_8 PF13855.1 ESA03433.1 - 1.5 8.5 18.4 0.098 12.4 2.3 4.2 2 1 2 4 4 4 0 Leucine rich repeat WD40 PF00400.27 ESA03435.1 - 6.8e-40 133.5 17.2 4.9e-10 38.9 0.1 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Mss4 PF04421.8 ESA03435.1 - 0.015 15.0 0.0 0.066 13.0 0.0 2.1 3 0 0 3 3 3 0 Mss4 protein RhoGAP PF00620.22 ESA03436.1 - 4.5e-37 126.9 0.2 1.3e-36 125.5 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.17 ESA03436.1 - 6.6e-28 96.5 35.9 4.6e-14 52.2 3.6 4.8 5 0 0 5 5 5 4 LIM domain TF_Zn_Ribbon PF08271.7 ESA03436.1 - 1 8.7 5.8 13 5.1 0.1 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding F-box-like PF12937.2 ESA03437.1 - 7.2e-06 25.6 0.8 1.4e-05 24.6 0.5 1.5 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.23 ESA03437.1 - 8.8e-06 25.1 0.2 3e-05 23.4 0.1 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.13 ESA03437.1 - 1.2e-05 25.0 0.5 2.6e-05 24.0 0.4 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 ESA03437.1 - 1.5e-05 24.5 0.1 4.2e-05 23.1 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03437.1 - 0.00017 21.1 0.3 0.00038 20.0 0.2 1.6 1 0 0 1 1 1 1 TPR repeat TPR_8 PF13181.1 ESA03437.1 - 0.00038 20.0 0.1 0.0018 17.8 0.1 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03437.1 - 0.004 17.0 0.3 0.014 15.3 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA03437.1 - 0.0096 15.6 0.1 0.029 14.1 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat F-box PF00646.28 ESA03437.1 - 0.012 15.2 0.9 0.031 13.9 0.6 1.7 1 0 0 1 1 1 0 F-box domain TPR_14 PF13428.1 ESA03437.1 - 0.056 14.0 0.0 0.15 12.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Spore_GerAC PF05504.6 ESA03437.1 - 0.46 10.2 4.1 0.47 10.2 1.1 2.1 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal YqeY PF09424.5 ESA03438.1 - 0.027 14.3 0.4 0.031 14.1 0.3 1.1 1 0 0 1 1 1 0 Yqey-like protein YqeY PF09424.5 ESA03439.1 - 9.5e-11 41.7 0.2 1.1e-10 41.4 0.1 1.1 1 0 0 1 1 1 1 Yqey-like protein LRR_8 PF13855.1 ESA03442.1 - 0.89 9.3 10.9 0.61 9.8 0.5 4.1 4 0 0 4 4 4 0 Leucine rich repeat 7TM_GPCR_Srh PF10318.4 ESA03444.1 - 0.011 14.5 0.1 0.019 13.8 0.0 1.4 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF1955 PF09205.5 ESA03445.1 - 0.077 12.5 0.2 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) TPX2 PF06886.6 ESA03446.1 - 1.3e-07 31.5 11.4 1.3e-07 31.5 7.9 4.2 4 0 0 4 4 4 2 Targeting protein for Xklp2 (TPX2) Pmp3 PF01679.12 ESA03447.1 - 1.4e-05 24.6 18.7 0.00047 19.8 2.0 2.6 3 0 0 3 3 3 2 Proteolipid membrane potential modulator DUF3817 PF12823.2 ESA03447.1 - 0.058 13.8 1.3 0.1 13.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) 7TM_GPCR_Srt PF10321.4 ESA03447.1 - 0.073 11.8 8.7 0.11 11.2 2.0 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt TcpE PF12648.2 ESA03447.1 - 2.8 8.1 8.5 1.1 9.4 2.9 2.0 1 1 1 2 2 2 0 TcpE family NdhL PF10716.4 ESA03448.1 - 0.4 10.4 2.2 0.6 9.9 1.0 1.7 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit DUF2326 PF10088.4 ESA03450.1 - 0.095 12.3 1.0 0.11 12.1 0.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2326) Spore_YhaL PF14147.1 ESA03450.1 - 0.12 11.7 1.1 0.17 11.3 0.8 1.3 1 0 0 1 1 1 0 Sporulation protein YhaL DUF4110 PF13422.1 ESA03450.1 - 0.15 11.9 0.6 0.23 11.3 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4110) Patatin PF01734.17 ESA03451.1 - 5.2e-15 55.9 0.1 4.7e-14 52.7 0.0 2.4 2 0 0 2 2 2 1 Patatin-like phospholipase TPR_19 PF14559.1 ESA03451.1 - 1.7e-05 25.0 0.0 1.7e-05 25.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA03451.1 - 0.00099 19.7 0.1 0.0048 17.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA03451.1 - 0.0043 17.1 2.2 0.0043 17.1 1.5 5.4 5 1 1 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ESA03451.1 - 0.028 14.0 23.4 0.057 13.0 0.4 5.5 4 1 1 6 6 6 0 TPR repeat Fis1_TPR_C PF14853.1 ESA03451.1 - 0.13 12.2 6.3 0.042 13.7 1.2 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.12 ESA03451.1 - 0.42 10.6 18.2 0.18 11.7 0.9 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA03451.1 - 0.61 10.4 4.3 4.4 7.7 0.1 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat Patatin PF01734.17 ESA03452.1 - 1.5e-13 51.1 0.0 3.7e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase TPR_19 PF14559.1 ESA03452.1 - 0.00034 20.8 0.1 0.014 15.7 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03452.1 - 0.33 10.6 0.0 0.33 10.6 0.0 5.4 4 1 2 6 6 6 0 TPR repeat TPR_2 PF07719.12 ESA03452.1 - 1.4 9.0 10.4 11 6.2 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Asp PF00026.18 ESA03454.1 - 1.7e-65 221.3 3.7 2.4e-65 220.8 2.6 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 ESA03454.1 - 3e-08 34.0 3.6 6.6e-05 23.3 0.4 3.4 3 2 1 4 4 4 2 Aspartyl protease gag-asp_proteas PF13975.1 ESA03454.1 - 0.00021 21.0 0.0 0.041 13.6 0.0 2.3 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_N PF14543.1 ESA03454.1 - 0.017 15.0 0.0 0.076 12.9 0.0 2.0 1 1 0 1 1 1 0 Xylanase inhibitor N-terminal RVP PF00077.15 ESA03454.1 - 0.024 14.5 0.1 0.79 9.6 0.0 2.7 2 1 0 2 2 2 0 Retroviral aspartyl protease TAXi_C PF14541.1 ESA03454.1 - 0.096 12.2 0.0 0.28 10.7 0.0 1.8 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Ribonuclease_3 PF00636.21 ESA03455.1 - 5.9e-07 29.9 1.7 1e-05 25.9 1.2 2.1 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 ESA03455.1 - 6.6e-06 26.0 0.1 3.3e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease-III-like Gaa1 PF04114.9 ESA03456.1 - 9.7e-106 354.4 5.5 1.3e-105 354.0 3.8 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component MMS19_N PF14500.1 ESA03457.1 - 9.2e-99 329.9 5.7 2.4e-98 328.5 0.1 3.7 4 0 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.3 ESA03457.1 - 1.9e-92 310.1 31.9 1.4e-90 304.0 13.8 3.9 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal HEAT_2 PF13646.1 ESA03457.1 - 8.8e-07 29.1 0.5 0.099 12.9 0.0 5.4 4 2 1 5 5 5 1 HEAT repeats HEAT_EZ PF13513.1 ESA03457.1 - 4.2e-05 23.9 1.2 0.096 13.2 0.0 6.0 4 2 2 6 6 6 2 HEAT-like repeat HEAT PF02985.17 ESA03457.1 - 0.022 14.7 0.3 6 7.2 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat ParcG PF10274.4 ESA03457.1 - 1.1 9.1 7.4 7.1 6.4 0.1 4.3 5 0 0 5 5 5 0 Parkin co-regulated protein ABC_membrane PF00664.18 ESA03458.1 - 1.5e-84 283.6 42.5 8.4e-49 166.4 10.2 3.5 3 1 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA03458.1 - 6.9e-50 168.9 0.0 1.2e-27 96.8 0.0 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA03458.1 - 7.3e-09 35.1 0.0 0.0031 16.7 0.0 4.0 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.18 ESA03458.1 - 4.1e-06 26.7 0.4 0.042 13.7 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.1 ESA03458.1 - 2.4e-05 24.4 1.0 0.83 9.5 0.1 4.4 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.1 ESA03458.1 - 3.8e-05 23.7 0.5 0.083 12.8 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain Miro PF08477.8 ESA03458.1 - 4e-05 24.0 1.1 0.045 14.2 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_25 PF13481.1 ESA03458.1 - 7.8e-05 22.1 0.2 0.28 10.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 ESA03458.1 - 9.7e-05 21.6 1.7 0.014 14.6 0.4 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA03458.1 - 0.00032 20.1 1.4 0.43 10.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.12 ESA03458.1 - 0.00044 20.1 2.7 0.52 10.0 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function DUF87 AAA_23 PF13476.1 ESA03458.1 - 0.00045 20.6 7.0 0.7 10.1 0.0 4.1 4 0 0 4 4 4 1 AAA domain Zeta_toxin PF06414.7 ESA03458.1 - 0.0024 16.9 0.5 0.12 11.4 0.1 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.1 ESA03458.1 - 0.0057 16.7 1.8 2.3 8.3 0.2 3.2 2 1 0 2 2 2 1 AAA domain MobB PF03205.9 ESA03458.1 - 0.0089 15.7 1.6 0.63 9.7 0.2 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 ESA03458.1 - 0.009 14.9 0.0 0.4 9.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_10 PF12846.2 ESA03458.1 - 0.019 14.4 0.3 3.1 7.1 0.2 2.5 2 0 0 2 2 2 0 AAA-like domain TrwB_AAD_bind PF10412.4 ESA03458.1 - 0.023 13.3 0.7 0.55 8.7 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 ESA03458.1 - 0.03 13.8 0.3 2.4 7.6 0.1 3.0 3 0 0 3 3 3 0 AAA domain GTP_EFTU PF00009.22 ESA03458.1 - 0.036 13.5 0.1 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.1 ESA03458.1 - 0.046 14.0 0.1 12 6.2 0.0 2.9 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 ESA03458.1 - 0.17 10.6 2.2 1.5 7.5 0.3 2.3 2 0 0 2 2 2 0 ArgK protein AAA_17 PF13207.1 ESA03458.1 - 0.33 11.7 7.6 1.4 9.7 0.0 3.3 3 1 0 3 3 2 0 AAA domain cobW PF02492.14 ESA03458.1 - 0.81 9.1 2.7 1.7 8.0 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 ESA03458.1 - 2.5 7.9 10.8 0.1 12.4 0.6 2.9 3 0 0 3 3 3 0 Dynamin family F-box-like PF12937.2 ESA03459.1 - 0.019 14.6 1.9 0.04 13.6 0.2 2.4 2 0 0 2 2 2 0 F-box-like LRR_4 PF12799.2 ESA03459.1 - 3.5 7.3 13.0 0.36 10.4 1.8 3.9 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) DDE_1 PF03184.14 ESA03460.1 - 6.7e-20 71.1 0.2 1e-19 70.5 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA03460.1 - 0.063 13.0 1.5 0.97 9.2 1.0 2.4 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain HNF-1_N PF04814.8 ESA03460.1 - 0.1 12.7 0.3 11 6.0 0.2 2.1 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Dimer_Tnp_hAT PF05699.9 ESA03462.1 - 6.9e-06 25.6 0.2 9.1e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-SNAP50_C PF12251.3 ESA03463.1 - 2.4e-05 23.8 3.4 0.035 13.4 0.3 2.2 1 1 1 2 2 2 2 snRNA-activating protein of 50kDa MW C terminal zf-C2H2_jaz PF12171.3 ESA03463.1 - 0.00043 20.3 2.8 0.66 10.1 0.1 2.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESA03463.1 - 0.00053 19.7 5.6 0.15 12.0 0.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 ESA03463.1 - 0.0013 18.8 1.0 1.4 9.2 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type Apc1 PF12859.2 ESA03463.1 - 0.014 15.6 0.4 0.7 10.1 0.2 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 1 Pep3_Vps18 PF05131.9 ESA03463.1 - 0.083 12.3 0.0 1.9 7.8 0.0 2.0 1 1 1 2 2 2 0 Pep3/Vps18/deep orange family C1_1 PF00130.17 ESA03463.1 - 0.09 12.5 0.6 11 5.7 0.0 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.24 ESA03463.1 - 0.17 11.6 1.1 14 5.4 0.1 2.4 2 1 0 2 2 2 0 PHD-finger zf-RING_5 PF14634.1 ESA03463.1 - 0.18 11.5 2.3 8.7 6.1 0.1 2.6 2 1 0 2 2 2 0 zinc-RING finger domain Ima1_N PF09779.4 ESA03463.1 - 0.21 12.0 1.4 0.8 10.2 1.0 1.8 1 1 1 2 2 2 0 Ima1 N-terminal domain zf-Dof PF02701.10 ESA03463.1 - 0.29 11.0 2.6 5.3 7.0 0.3 2.3 1 1 1 2 2 2 0 Dof domain, zinc finger zf-H2C2_2 PF13465.1 ESA03463.1 - 0.71 10.2 5.7 12 6.3 0.1 2.7 2 1 0 2 2 2 0 Zinc-finger double domain zf-B_box PF00643.19 ESA03463.1 - 0.87 9.5 5.4 11 5.9 0.3 2.4 2 0 0 2 2 2 0 B-box zinc finger zf-C2HC_2 PF13913.1 ESA03463.1 - 0.96 9.1 7.5 2.4 7.9 0.2 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type MT-A70 PF05063.9 ESA03464.1 - 9.1e-40 136.0 0.0 1.1e-39 135.8 0.0 1.0 1 0 0 1 1 1 1 MT-A70 APH PF01636.18 ESA03465.1 - 6e-09 35.9 0.0 8.6e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.9 ESA03465.1 - 0.0011 18.0 0.0 0.0013 17.7 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase Macoilin PF09726.4 ESA03465.1 - 0.07 11.4 0.4 0.079 11.2 0.3 1.0 1 0 0 1 1 1 0 Transmembrane protein SR-25 PF10500.4 ESA03465.1 - 0.86 9.0 8.8 1.1 8.6 6.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Toxin_11 PF07473.6 ESA03465.1 - 9.8 6.1 7.1 16 5.5 0.6 3.3 3 0 0 3 3 3 0 Spasmodic peptide gm9a PLU-1 PF08429.6 ESA03469.1 - 0.07 12.0 0.1 0.073 11.9 0.0 1.0 1 0 0 1 1 1 0 PLU-1-like protein CPSase_L_D3 PF02787.14 ESA03469.1 - 0.08 12.7 0.0 0.094 12.4 0.0 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Anillin PF08174.6 ESA03472.1 - 0.006 16.6 0.1 0.0065 16.5 0.1 1.1 1 0 0 1 1 1 1 Cell division protein anillin HTH_Tnp_IS630 PF01710.11 ESA03472.1 - 0.028 14.0 0.3 0.04 13.5 0.2 1.2 1 0 0 1 1 1 0 Transposase HTH_28 PF13518.1 ESA03472.1 - 0.036 14.0 0.4 0.071 13.1 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.15 ESA03472.1 - 0.14 12.0 0.3 0.39 10.6 0.1 1.8 2 0 0 2 2 2 0 Transposase PIF1 PF05970.9 ESA03473.1 - 8e-07 28.3 0.0 2.1e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 PIF1-like helicase Herpes_Helicase PF02689.9 ESA03473.1 - 0.0011 16.7 0.0 0.0016 16.2 0.0 1.3 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA03473.1 - 0.045 13.9 0.0 0.074 13.2 0.0 1.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain PIF1 PF05970.9 ESA03474.1 - 2.5e-17 62.8 1.0 2.9e-10 39.6 0.2 2.0 1 1 1 2 2 2 2 PIF1-like helicase Ish1 PF10281.4 ESA03475.1 - 0.05 13.6 0.1 0.11 12.5 0.1 1.6 1 1 0 1 1 1 0 Putative stress-responsive nuclear envelope protein PAH PF02671.16 ESA03477.1 - 1.8e-06 27.4 0.3 3.2e-06 26.6 0.2 1.4 1 0 0 1 1 1 1 Paired amphipathic helix repeat DsrD PF08679.6 ESA03477.1 - 0.19 11.7 0.8 24 5.0 0.2 2.6 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) DUF4414 PF14377.1 ESA03478.1 - 0.023 14.5 0.4 0.026 14.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4414) MCLC PF05934.6 ESA03478.1 - 0.037 12.3 4.5 0.036 12.3 3.1 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DUF3446 PF11928.3 ESA03478.1 - 0.091 12.9 1.5 0.1 12.7 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF3403 PF11883.3 ESA03478.1 - 0.15 12.3 4.4 0.13 12.5 1.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3403) ABC_membrane PF00664.18 ESA03479.1 - 4.3e-110 367.4 32.4 7.1e-61 206.0 6.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA03479.1 - 1.5e-73 245.5 0.2 3e-36 124.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA03479.1 - 4.4e-18 65.3 6.3 3.8e-08 32.8 0.0 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 ESA03479.1 - 1.7e-10 40.1 1.4 0.00011 20.9 0.1 3.4 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_21 PF13304.1 ESA03479.1 - 2e-08 34.5 14.8 0.0063 16.5 0.1 5.5 4 2 0 4 4 4 2 AAA domain AAA_29 PF13555.1 ESA03479.1 - 2.8e-08 33.1 3.7 0.0038 16.7 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ESA03479.1 - 6.8e-08 31.8 0.3 0.0067 15.6 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA03479.1 - 1.6e-07 32.1 0.5 0.019 15.7 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 ESA03479.1 - 3.1e-07 30.5 3.1 0.021 14.8 0.1 3.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 ESA03479.1 - 1.3e-06 28.5 4.1 0.0048 17.0 0.2 3.8 2 2 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 ESA03479.1 - 7.8e-05 22.5 3.4 0.053 13.4 0.2 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.7 ESA03479.1 - 9.5e-05 21.5 0.1 1.7 7.6 0.0 3.4 3 0 0 3 3 3 2 Zeta toxin AAA_18 PF13238.1 ESA03479.1 - 0.0002 21.6 1.0 1 9.7 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.1 ESA03479.1 - 0.00022 21.1 0.1 0.42 10.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 ESA03479.1 - 0.0003 20.4 2.4 0.094 12.4 0.1 3.5 4 0 0 4 4 2 1 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.15 ESA03479.1 - 0.00052 19.6 0.2 0.21 11.2 0.0 2.7 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_30 PF13604.1 ESA03479.1 - 0.0007 19.2 0.5 3.9 6.9 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.1 ESA03479.1 - 0.00073 18.9 0.3 1.7 8.0 0.0 3.1 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.18 ESA03479.1 - 0.00092 19.1 1.3 0.17 11.8 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase CbiA PF01656.18 ESA03479.1 - 0.0016 17.8 1.1 0.068 12.5 0.0 3.2 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF815 PF05673.8 ESA03479.1 - 0.0018 17.2 0.1 0.8 8.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) SRP54 PF00448.17 ESA03479.1 - 0.0022 17.4 0.1 0.45 9.9 0.0 2.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_5 PF07728.9 ESA03479.1 - 0.0057 16.3 0.4 2.8 7.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 ESA03479.1 - 0.0072 15.8 5.2 1.4 8.2 0.0 3.9 3 1 0 4 4 4 1 AAA-like domain Miro PF08477.8 ESA03479.1 - 0.021 15.3 0.2 8.5 6.9 0.0 2.9 2 0 0 2 2 2 0 Miro-like protein PRK PF00485.13 ESA03479.1 - 0.021 14.4 0.1 3.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.1 ESA03479.1 - 0.029 14.3 0.7 8.4 6.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESA03479.1 - 0.036 13.8 13.8 0.25 11.1 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function DUF87 AAA_23 PF13476.1 ESA03479.1 - 0.039 14.2 9.4 1.5 9.1 0.0 3.6 3 1 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.20 ESA03479.1 - 0.045 13.2 0.0 7.7 5.9 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.13 ESA03479.1 - 0.067 12.6 0.5 9.5 5.6 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.7 ESA03479.1 - 0.1 12.2 1.1 15 5.2 0.1 2.7 2 0 0 2 2 2 0 NACHT domain CDC45 PF02724.9 ESA03479.1 - 0.23 9.4 5.4 0.46 8.4 3.7 1.4 1 0 0 1 1 1 0 CDC45-like protein zf-MYND PF01753.13 ESA03480.1 - 8.9e-08 31.8 16.1 8.9e-08 31.8 11.2 2.8 3 0 0 3 3 3 1 MYND finger SET PF00856.23 ESA03480.1 - 1e-07 32.4 3.0 2.8e-07 30.9 2.1 1.9 1 1 0 1 1 1 1 SET domain Prp18 PF02840.10 ESA03480.1 - 0.015 15.1 1.0 0.015 15.1 0.7 2.4 2 0 0 2 2 2 0 Prp18 domain TFCD_C PF12612.3 ESA03480.1 - 0.036 13.4 0.3 0.036 13.4 0.2 2.1 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal F-box-like PF12937.2 ESA03481.1 - 0.021 14.5 0.2 0.065 12.9 0.2 1.8 1 0 0 1 1 1 0 F-box-like Pox_RNA_Pol_22 PF05273.8 ESA03481.1 - 0.47 10.0 8.8 0.14 11.8 0.4 3.0 3 0 0 3 3 3 0 Poxvirus RNA polymerase 22 kDa subunit rpo132 PF12415.3 ESA03482.1 - 0.00027 19.8 0.1 0.35 9.8 0.0 2.3 2 0 0 2 2 2 2 Poxvirus DNA dependent RNA polymerase DUF4595 PF15283.1 ESA03483.1 - 0.02 14.5 2.3 0.025 14.2 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold CHASE4 PF05228.8 ESA03483.1 - 0.23 11.0 2.9 0.28 10.7 2.0 1.1 1 0 0 1 1 1 0 CHASE4 domain Ku_N PF03731.10 ESA03484.1 - 0.055 12.8 2.3 0.16 11.4 0.2 2.1 2 0 0 2 2 2 0 Ku70/Ku80 N-terminal alpha/beta domain NCA2 PF08637.5 ESA03485.1 - 0.058 12.2 0.1 0.089 11.6 0.1 1.2 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 Phage_GP20 PF06810.6 ESA03487.1 - 0.0034 16.8 2.2 0.004 16.5 1.5 1.1 1 0 0 1 1 1 1 Phage minor structural protein GP20 DUF3552 PF12072.3 ESA03487.1 - 0.0066 15.6 1.0 0.0077 15.4 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) PSI_PsaF PF02507.10 ESA03487.1 - 0.012 15.2 0.2 0.013 15.0 0.2 1.1 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III ABC_tran_2 PF12848.2 ESA03487.1 - 0.016 15.0 2.1 0.016 15.0 1.4 1.3 1 1 0 1 1 1 0 ABC transporter Med9 PF07544.8 ESA03487.1 - 0.021 14.5 1.6 0.027 14.1 1.1 1.1 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 IFT57 PF10498.4 ESA03487.1 - 0.031 13.0 0.5 0.036 12.8 0.3 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 GAS PF13851.1 ESA03487.1 - 0.033 13.3 1.2 0.04 13.0 0.8 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIVA PF05103.8 ESA03487.1 - 0.039 14.0 0.4 0.047 13.7 0.3 1.1 1 0 0 1 1 1 0 DivIVA protein HR1 PF02185.11 ESA03487.1 - 0.049 13.3 0.5 0.049 13.3 0.3 1.9 1 1 1 2 2 2 0 Hr1 repeat BLOC1_2 PF10046.4 ESA03487.1 - 0.051 13.7 0.9 0.065 13.3 0.6 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.7 ESA03487.1 - 0.054 13.7 0.1 0.075 13.2 0.1 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FliD_N PF02465.13 ESA03487.1 - 0.074 13.4 1.2 0.092 13.1 0.8 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF2951 PF11166.3 ESA03487.1 - 0.17 11.7 1.2 0.2 11.5 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Prefoldin_2 PF01920.15 ESA03487.1 - 0.91 9.3 5.2 0.85 9.4 0.7 2.0 1 1 1 2 2 2 0 Prefoldin subunit TMF_DNA_bd PF12329.3 ESA03487.1 - 1.6 8.5 5.9 2.7 7.8 4.1 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding p450 PF00067.17 ESA03488.1 - 3.5e-48 164.2 0.2 4.3e-48 164.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ag332 PF04671.7 ESA03492.1 - 0.64 9.8 12.7 1.9 8.3 0.9 3.3 2 1 1 3 3 3 0 Erythrocyte membrane-associated giant protein antigen 332 DUF3236 PF11576.3 ESA03493.1 - 0.021 14.2 1.2 1.8 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3236) UvrD-helicase PF00580.16 ESA03494.1 - 3.3e-07 29.9 0.4 4.7e-07 29.3 0.3 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 ESA03494.1 - 0.028 13.9 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TOM_sub5 PF15178.1 ESA03496.1 - 0.0066 16.1 0.0 0.0075 15.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM5 homolog Glyoxalase PF00903.20 ESA03497.1 - 7e-24 84.2 0.1 8e-24 84.0 0.1 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 ESA03497.1 - 3.4e-17 63.0 0.0 6.1e-17 62.1 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 ESA03497.1 - 1.5e-07 31.3 0.0 7.2e-07 29.1 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MKT1_C PF12246.3 ESA03498.1 - 1e-63 214.6 0.9 1.1e-63 214.4 0.6 1.0 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication Exonuc_V_gamma PF04257.9 ESA03498.1 - 0.071 11.0 0.2 0.1 10.5 0.1 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit MKT1_N PF12247.3 ESA03499.1 - 7.9e-11 42.1 0.2 2.2e-10 40.7 0.1 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_I PF00867.13 ESA03499.1 - 0.03 14.3 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 XPG I-region XPG_N PF00752.12 ESA03500.1 - 0.0015 18.7 0.0 0.0015 18.7 0.0 1.1 1 0 0 1 1 1 1 XPG N-terminal domain Yip1 PF04893.12 ESA03501.1 - 1.2e-17 63.8 17.2 2.3e-17 63.0 11.9 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.7 ESA03501.1 - 0.00066 19.3 7.5 0.00096 18.8 5.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) TLD PF07534.11 ESA03504.1 - 1.1e-15 57.8 7.9 1.9e-14 53.8 0.1 4.2 3 1 0 3 3 3 1 TLD BACK PF07707.10 ESA03504.1 - 0.00033 20.4 1.0 0.016 15.0 0.1 2.4 1 1 1 2 2 2 2 BTB And C-terminal Kelch CCDC32 PF14989.1 ESA03505.1 - 0.078 12.8 0.4 0.078 12.8 0.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing 32 Ribosomal_S16 PF00886.14 ESA03506.1 - 6e-25 86.7 0.1 6.9e-25 86.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 TLD PF07534.11 ESA03507.1 - 1.5e-12 47.6 2.3 1.8e-12 47.4 0.2 2.0 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA03507.1 - 0.0002 21.3 0.0 0.00038 20.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA03507.1 - 0.00036 20.3 0.0 0.011 15.5 0.0 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch Period_C PF12114.3 ESA03508.1 - 0.012 15.1 0.3 0.012 15.1 0.2 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Phospholip_A2_3 PF09056.6 ESA03508.1 - 0.65 10.2 3.9 0.88 9.7 1.6 1.7 1 1 1 2 2 2 0 Prokaryotic phospholipase A2 TRAP_alpha PF03896.11 ESA03508.1 - 1.7 7.5 5.3 1.8 7.4 3.7 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Calici_MSP PF05752.6 ESA03509.1 - 0.16 11.5 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 Calicivirus minor structural protein POTRA_1 PF08478.5 ESA03510.1 - 0.086 12.8 0.0 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 POTRA domain, FtsQ-type LRR_1 PF00560.28 ESA03510.1 - 0.36 11.0 6.5 1.9 8.8 0.0 4.2 5 0 0 5 5 5 0 Leucine Rich Repeat FBA_2 PF07735.12 ESA03510.1 - 2.1 8.2 12.0 3.5 7.5 2.3 4.4 4 2 1 5 5 5 0 F-box associated PDZ_1 PF12812.2 ESA03516.1 - 2.6e-31 107.3 0.0 1.3e-24 85.8 0.0 2.9 3 0 0 3 3 3 2 PDZ-like domain PDZ_2 PF13180.1 ESA03516.1 - 8.4e-20 70.4 3.3 3.4e-06 26.8 0.0 5.0 5 0 0 5 5 5 4 PDZ domain Trypsin_2 PF13365.1 ESA03516.1 - 1.7e-09 37.7 0.0 5.7e-08 32.7 0.0 2.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ PF00595.19 ESA03516.1 - 9.3e-07 28.9 0.3 0.1 12.8 0.0 3.4 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) Peptidase_S3 PF00944.14 ESA03516.1 - 0.07 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S7 PF00949.16 ESA03516.1 - 0.1 12.0 1.1 0.24 10.8 0.8 1.6 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.4 ESA03516.1 - 0.21 9.9 0.2 0.34 9.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase S46 RdRP PF05183.7 ESA03517.1 - 8.8e-175 582.6 0.3 1.9e-174 581.6 0.2 1.5 1 1 0 1 1 1 1 RNA dependent RNA polymerase RRM_6 PF14259.1 ESA03517.1 - 1.4e-09 37.7 0.0 4.8e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA03517.1 - 9.9e-09 34.7 0.1 2.9e-08 33.2 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03517.1 - 0.042 13.7 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) dsrm PF00035.20 ESA03518.1 - 0.00085 19.8 2.3 0.0059 17.1 0.1 3.4 4 0 0 4 4 4 1 Double-stranded RNA binding motif DUF3867 PF12983.2 ESA03519.1 - 0.0083 16.1 0.3 0.0096 15.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3867) DUF3783 PF12646.2 ESA03519.1 - 0.11 12.2 0.1 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) HSDR_N_2 PF13588.1 ESA03521.1 - 0.04 13.7 0.0 0.075 12.8 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) SAM_1 PF00536.25 ESA03523.1 - 0.04 14.0 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) WhiA_N PF10298.4 ESA03524.1 - 0.068 13.0 2.1 2.4 8.0 0.1 2.2 1 1 1 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain Med8 PF10232.4 ESA03525.1 - 0.14 11.6 7.2 0.17 11.4 5.0 1.0 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF3994 PF13159.1 ESA03525.1 - 0.43 10.8 5.5 0.8 9.9 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) Cep57_MT_bd PF06657.8 ESA03525.1 - 0.48 10.4 6.2 0.17 11.8 2.4 1.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.1 ESA03525.1 - 1.3 7.9 4.4 1.4 7.8 3.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Asp-B-Hydro_N PF05279.6 ESA03525.1 - 1.7 8.4 11.6 2 8.2 8.1 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region zf-CpG_bind_C PF12269.3 ESA03525.1 - 3.5 7.0 6.8 3.8 6.9 4.7 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain V_ATPase_I PF01496.14 ESA03525.1 - 7.3 4.3 7.0 7 4.3 4.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-U1 PF06220.7 ESA03526.1 - 0.026 14.0 1.4 0.047 13.2 1.0 1.4 1 0 0 1 1 1 0 U1 zinc finger IFNGR1 PF07140.6 ESA03526.1 - 0.1 12.2 1.6 0.17 11.6 1.1 1.5 1 1 0 1 1 1 0 Interferon gamma receptor (IFNGR1) HTH_32 PF13565.1 ESA03527.1 - 5.2e-10 39.9 1.6 1.9e-08 34.9 0.8 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.1 ESA03527.1 - 8.3e-08 32.3 0.1 9.2e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA03527.1 - 1.8e-05 24.2 0.0 3.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 ESA03527.1 - 2.7e-05 24.0 0.3 5.9e-05 22.9 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 ESA03527.1 - 0.015 15.3 0.3 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 Transposase PAX PF00292.13 ESA03527.1 - 0.021 14.5 0.3 0.025 14.3 0.2 1.0 1 0 0 1 1 1 0 'Paired box' domain Terminase_5 PF06056.7 ESA03527.1 - 0.028 13.9 1.3 0.039 13.5 0.9 1.4 1 1 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) PP_kinase_N PF13089.1 ESA03527.1 - 0.034 14.2 0.3 0.038 14.0 0.2 1.1 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain HTH_40 PF14493.1 ESA03527.1 - 0.05 13.8 0.6 0.069 13.3 0.4 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.10 ESA03527.1 - 0.11 12.4 0.0 20 5.1 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.7 ESA03527.1 - 0.11 11.9 0.1 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 Sigma-70, region 4 Arg_repressor PF01316.16 ESA03527.1 - 0.13 11.8 0.7 0.21 11.1 0.5 1.3 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HD PF01966.17 ESA03528.1 - 1.1e-12 48.0 0.1 3e-12 46.6 0.1 1.8 1 0 0 1 1 1 1 HD domain DUF4391 PF14335.1 ESA03530.1 - 0.014 14.8 0.1 0.015 14.6 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) MULE PF10551.4 ESA03531.1 - 1.8e-06 28.0 0.6 2.7e-06 27.4 0.4 1.3 1 1 0 1 1 1 1 MULE transposase domain Vip3A_N PF12495.3 ESA03532.1 - 0.068 12.8 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal SMN PF06003.7 ESA03536.1 - 0.11 11.6 2.5 0.12 11.4 1.7 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) SURF2 PF05477.6 ESA03536.1 - 1 8.4 3.6 1.2 8.2 2.5 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) zf-Paramyx-P PF13008.2 ESA03537.1 - 0.0047 16.0 0.2 0.0074 15.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding domain of Paramyxoviridae V protein DUF1725 PF08333.6 ESA03537.1 - 0.45 9.9 3.1 0.7 9.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) TPR_MLP1_2 PF07926.7 ESA03538.1 - 0.56 9.9 3.6 1.5 8.5 0.1 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.20 ESA03539.1 - 2.4e-12 46.5 0.1 4.7e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03539.1 - 2.5e-09 36.6 0.0 3.8e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase zf-C2H2 PF00096.21 ESA03540.1 - 0.00041 20.5 1.1 0.0012 19.0 0.7 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 ESA03540.1 - 0.031 14.4 1.0 0.07 13.3 0.7 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA03540.1 - 0.057 13.3 1.4 0.12 12.3 0.9 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA03540.1 - 0.088 12.9 0.5 0.21 11.7 0.3 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding RNase_H PF00075.19 ESA03542.1 - 0.00011 22.4 0.0 0.087 13.1 0.0 2.3 1 1 1 2 2 2 2 RNase H Cyanate_lyase PF02560.9 ESA03543.1 - 0.098 12.2 0.0 0.36 10.3 0.0 2.1 1 1 0 1 1 1 0 Cyanate lyase C-terminal domain Pkinase_Tyr PF07714.12 ESA03545.1 - 6.7e-11 41.7 0.0 7.3e-11 41.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03545.1 - 2.4e-07 30.1 0.0 3e-07 29.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF4264 PF14084.1 ESA03545.1 - 0.032 13.6 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) SLBP_RNA_bind PF15247.1 ESA03545.1 - 0.067 12.9 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Histone RNA hairpin-binding protein RNA-binding domain Pkinase_Tyr PF07714.12 ESA03546.1 - 6.4e-39 133.5 0.0 1.3e-38 132.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03546.1 - 1.7e-34 119.1 1.2 7.7e-34 117.0 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA03546.1 - 3e-27 94.4 10.4 2.6e-09 37.3 1.4 4.5 4 0 0 4 4 4 4 Sel1 repeat Kdo PF06293.9 ESA03546.1 - 1.8e-05 23.9 0.0 3.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA03546.1 - 0.0016 17.7 0.4 0.0046 16.3 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA03546.1 - 0.0081 15.1 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like MIT PF04212.13 ESA03546.1 - 0.69 9.8 3.6 41 4.1 0.1 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.12 ESA03547.1 - 7.7e-38 130.0 0.0 1.2e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA03547.1 - 6.9e-31 105.9 11.9 4e-10 40.0 0.1 4.5 4 0 0 4 4 4 4 Sel1 repeat Pkinase PF00069.20 ESA03547.1 - 8.3e-30 103.7 0.3 2.2e-29 102.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ESA03547.1 - 0.0024 16.8 0.0 0.011 14.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA03547.1 - 0.0031 16.5 0.0 0.0071 15.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA03547.1 - 0.0059 16.3 0.0 0.0099 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family T2SM_b PF10741.4 ESA03547.1 - 0.2 11.2 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b Pkinase PF00069.20 ESA03548.1 - 2.2e-39 135.2 0.2 2.6e-39 134.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03548.1 - 6e-35 120.5 0.0 7.9e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA03548.1 - 0.00066 19.4 0.0 0.0014 18.4 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA03548.1 - 0.0019 17.2 0.0 0.0028 16.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA03548.1 - 0.0042 16.4 0.2 0.0058 16.0 0.1 1.3 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA03548.1 - 0.0057 15.9 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.15 ESA03548.1 - 0.027 14.0 0.3 0.064 12.8 0.1 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 ESA03548.1 - 0.06 12.4 0.0 0.086 11.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA03549.1 - 4.8e-35 119.2 9.3 1.8e-09 37.8 0.1 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA03549.1 - 0.016 15.6 7.3 15 6.3 0.0 5.4 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA03549.1 - 0.11 12.8 0.3 11 6.4 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat Ufm1 PF03671.9 ESA03549.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 2 0 0 2 2 2 0 Ubiquitin fold modifier 1 protein B-block_TFIIIC PF04182.7 ESA03550.1 - 0.016 14.9 0.1 0.023 14.5 0.1 1.3 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC TMEM141 PF15110.1 ESA03551.1 - 0.018 15.3 1.1 0.018 15.3 0.7 1.0 1 0 0 1 1 1 0 TMEM141 protein family DUF3149 PF11346.3 ESA03551.1 - 1.6 8.3 4.2 16 5.1 2.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3149) LsmAD PF06741.8 ESA03554.1 - 0.064 13.3 0.1 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 LsmAD domain Ribosomal_S6 PF01250.12 ESA03554.1 - 0.16 11.8 0.4 0.64 9.8 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein S6 Transposase_24 PF03004.9 ESA03555.1 - 1.1 9.1 8.2 8.1 6.3 5.7 2.3 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) Pox_D5 PF03288.11 ESA03558.1 - 0.0016 18.6 0.0 0.0027 17.9 0.0 1.4 1 0 0 1 1 1 1 Poxvirus D5 protein-like NAD_binding_9 PF13454.1 ESA03560.1 - 0.013 15.3 0.0 0.013 15.2 0.0 1.0 1 0 0 1 1 1 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA03560.1 - 0.025 14.5 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF4606 PF15379.1 ESA03561.1 - 0.033 14.2 0.3 0.042 13.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) SH2 PF00017.19 ESA03563.1 - 0.08 12.7 0.2 0.2 11.4 0.0 1.7 1 1 1 2 2 2 0 SH2 domain SPK PF04435.13 ESA03563.1 - 0.11 12.4 0.8 0.27 11.2 0.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF545) DivIC PF04977.10 ESA03565.1 - 0.00064 19.1 9.0 0.053 13.0 0.2 3.2 1 1 1 2 2 2 2 Septum formation initiator Lge1 PF11488.3 ESA03565.1 - 0.12 12.6 0.3 0.12 12.6 0.2 2.9 1 1 2 3 3 3 0 Transcriptional regulatory protein LGE1 Shugoshin_N PF07558.6 ESA03565.1 - 0.41 10.4 7.1 5.6 6.7 0.8 3.6 2 2 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF972 PF06156.8 ESA03565.1 - 0.43 10.9 11.2 0.73 10.1 1.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 ESA03565.1 - 2.1 8.2 16.9 9.4 6.1 5.1 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 ESA03565.1 - 2.6 8.5 5.3 1e+02 3.3 0.0 3.4 3 0 0 3 3 3 0 SlyX DivIVA PF05103.8 ESA03565.1 - 3.7 7.5 10.8 2.6 8.1 0.4 3.1 2 1 1 3 3 3 0 DivIVA protein bZIP_2 PF07716.10 ESA03565.1 - 9 6.2 21.1 3.4 7.5 0.4 4.2 3 1 1 4 4 4 0 Basic region leucine zipper DUF3990 PF13151.1 ESA03566.1 - 0.0077 15.6 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) DNA_pol_B PF00136.16 ESA03574.1 - 6.7e-50 170.2 1.5 1e-49 169.6 1.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B PF00136.16 ESA03576.1 - 1.4e-49 169.1 0.3 2.6e-49 168.2 0.2 1.4 1 1 0 1 1 1 1 DNA polymerase family B TT_ORF2 PF02957.10 ESA03576.1 - 0.54 10.9 3.2 0.99 10.1 2.2 1.4 1 0 0 1 1 1 0 TT viral ORF2 zf-3CxxC PF13695.1 ESA03577.1 - 4.9e-05 23.4 4.5 4.9e-05 23.4 3.1 5.6 3 2 1 4 4 4 2 Zinc-binding domain Saccharop_dh PF03435.13 ESA03580.1 - 7.3e-25 87.7 0.0 8.6e-22 77.6 0.0 2.1 2 0 0 2 2 2 2 Saccharopine dehydrogenase NAD_binding_4 PF07993.7 ESA03580.1 - 0.0007 18.6 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 ESA03580.1 - 0.0011 19.0 0.1 0.013 15.5 0.1 2.1 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESA03580.1 - 0.0091 15.4 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA03580.1 - 0.016 13.8 0.0 0.024 13.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 ESA03580.1 - 0.03 13.5 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.10 ESA03580.1 - 0.13 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DBR1 PF05011.8 ESA03581.1 - 6.5e-38 129.8 2.3 1.3e-37 128.9 1.6 1.5 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.23 ESA03581.1 - 4e-10 39.4 2.2 7.7e-10 38.4 1.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA03581.1 - 0.0002 21.2 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MMR_HSR1 PF01926.18 ESA03582.1 - 0.00014 21.7 0.0 0.00034 20.5 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA03582.1 - 0.0021 18.3 0.1 0.003 17.8 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AIG1 PF04548.11 ESA03582.1 - 0.0045 16.1 1.1 0.3 10.1 0.8 2.2 1 1 0 1 1 1 1 AIG1 family IIGP PF05049.8 ESA03582.1 - 0.022 13.5 0.8 0.099 11.4 0.2 2.1 2 1 0 2 2 2 0 Interferon-inducible GTPase (IIGP) DUF258 PF03193.11 ESA03582.1 - 0.049 12.8 0.1 0.077 12.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 ESA03582.1 - 0.28 11.4 2.9 0.54 10.5 2.0 1.5 1 1 0 1 1 1 0 AAA domain bcl-2I13 PF12201.3 ESA03583.1 - 0.12 11.7 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 Bcl2-interacting killer, BH3-domain containing RXT2_N PF08595.6 ESA03585.1 - 0.081 12.7 6.7 0.15 11.8 1.9 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.5 ESA03585.1 - 0.34 11.1 9.4 0.19 11.9 4.6 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AAA_18 PF13238.1 ESA03585.1 - 0.93 9.8 4.4 2.8 8.2 3.0 1.9 1 1 0 1 1 1 0 AAA domain Med10 PF09748.4 ESA03586.1 - 0.00039 20.2 3.9 0.003 17.3 2.7 2.1 1 1 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Filament PF00038.16 ESA03586.1 - 0.0057 16.1 16.0 0.1 12.0 3.8 2.1 1 1 1 2 2 2 2 Intermediate filament protein LIME1 PF15332.1 ESA03586.1 - 0.057 12.6 2.0 0.56 9.3 0.4 2.1 2 0 0 2 2 2 0 Lck-interacting transmembrane adapter 1 DUF3637 PF12337.3 ESA03586.1 - 0.071 13.1 1.6 0.51 10.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3637) Lebercilin PF15619.1 ESA03586.1 - 0.076 12.4 18.8 0.13 11.6 1.6 3.2 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.7 ESA03586.1 - 0.079 12.6 21.4 0.099 12.3 1.5 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.7 ESA03586.1 - 0.097 12.4 7.7 1.3 8.8 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MecA_N PF05223.6 ESA03586.1 - 0.13 12.3 1.6 0.2 11.7 0.6 1.7 1 1 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain Peptidase_S46 PF10459.4 ESA03586.1 - 0.2 10.0 6.4 0.25 9.7 4.4 1.0 1 0 0 1 1 1 0 Peptidase S46 Phlebovirus_NSM PF07246.6 ESA03586.1 - 0.3 10.2 9.5 0.34 10.0 0.9 2.1 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M XhlA PF10779.4 ESA03586.1 - 0.49 10.3 8.1 0.22 11.4 1.9 2.4 2 1 0 2 2 2 0 Haemolysin XhlA AAA_13 PF13166.1 ESA03586.1 - 0.69 8.3 18.2 0.45 8.8 5.3 2.0 2 0 0 2 2 2 0 AAA domain DUF730 PF05325.6 ESA03586.1 - 0.94 9.2 3.6 1.2 8.8 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF730) Mnd1 PF03962.10 ESA03586.1 - 1.3 8.6 16.0 2.8 7.5 1.2 2.3 2 0 0 2 2 2 0 Mnd1 family DUF4407 PF14362.1 ESA03586.1 - 2 7.2 6.6 4.7 6.0 4.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.3 ESA03586.1 - 3.4 4.8 15.5 11 3.2 10.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.6 ESA03586.1 - 4 7.2 19.7 4.3 7.1 6.9 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4094 PF13334.1 ESA03586.1 - 6.6 7.1 11.0 6.4 7.2 3.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4094) SlyX PF04102.7 ESA03586.1 - 6.9 7.1 8.2 64 4.0 0.0 3.9 2 1 0 3 3 3 0 SlyX DUF904 PF06005.7 ESA03586.1 - 8.1 6.8 20.3 29 5.0 2.9 4.0 1 1 2 3 3 3 0 Protein of unknown function (DUF904) V_ATPase_I PF01496.14 ESA03586.1 - 9.5 3.9 10.6 16 3.1 7.3 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DNA_pol_B PF00136.16 ESA03587.1 - 4.2e-25 88.4 9.1 3.7e-15 55.6 0.1 2.7 3 0 0 3 3 3 2 DNA polymerase family B DNA_pol_B PF00136.16 ESA03588.1 - 2e-21 76.3 2.1 2.5e-21 76.0 1.5 1.0 1 0 0 1 1 1 1 DNA polymerase family B Baculo_E56 PF04639.7 ESA03588.1 - 0.13 10.8 0.7 0.19 10.3 0.5 1.1 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope MscS_porin PF12795.2 ESA03589.1 - 4e-06 26.3 8.8 5.1e-06 25.9 6.1 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain BicD PF09730.4 ESA03589.1 - 7.7e-05 21.2 2.5 8.6e-05 21.1 1.8 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D FH2 PF02181.18 ESA03589.1 - 0.00021 20.3 5.9 0.00028 19.9 4.1 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain NPV_P10 PF05531.7 ESA03589.1 - 0.00021 21.4 3.3 0.016 15.4 0.1 2.8 1 1 2 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.3 ESA03589.1 - 0.00023 18.7 5.6 0.00026 18.5 3.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) GAS PF13851.1 ESA03589.1 - 0.00034 19.8 13.0 0.00093 18.4 3.1 2.3 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding CENP-Q PF13094.1 ESA03589.1 - 0.00048 20.1 12.3 0.038 14.0 0.6 2.1 1 1 1 2 2 2 2 CENP-Q, a CENPA-CAD centromere complex subunit TBPIP PF07106.8 ESA03589.1 - 0.00059 19.4 12.2 0.00075 19.0 4.5 2.1 1 1 1 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF812 PF05667.6 ESA03589.1 - 0.00097 17.7 7.0 0.0011 17.5 4.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Spc7 PF08317.6 ESA03589.1 - 0.0011 17.6 11.0 0.0014 17.3 7.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ATG16 PF08614.6 ESA03589.1 - 0.0044 16.8 13.7 0.26 11.0 3.5 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) IncA PF04156.9 ESA03589.1 - 0.0046 16.5 17.9 0.023 14.3 12.4 1.8 1 1 0 1 1 1 1 IncA protein CENP-F_leu_zip PF10473.4 ESA03589.1 - 0.0049 16.7 14.1 0.0081 16.0 9.7 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 ESA03589.1 - 0.0058 16.3 11.4 0.037 13.7 7.1 2.0 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein EzrA PF06160.7 ESA03589.1 - 0.0063 14.7 9.7 0.0085 14.3 6.7 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA HR1 PF02185.11 ESA03589.1 - 0.0066 16.1 15.1 1.1 8.9 1.0 3.3 1 1 2 3 3 3 1 Hr1 repeat DivIC PF04977.10 ESA03589.1 - 0.0067 15.8 12.3 0.013 14.9 1.5 3.0 1 1 1 2 2 2 1 Septum formation initiator LRS4 PF10422.4 ESA03589.1 - 0.0072 15.7 5.9 0.0096 15.2 4.1 1.2 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 V_ATPase_I PF01496.14 ESA03589.1 - 0.0082 14.0 4.2 0.0099 13.7 2.9 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Phasin PF05597.6 ESA03589.1 - 0.01 15.6 3.6 0.055 13.2 0.6 2.3 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) APG6 PF04111.7 ESA03589.1 - 0.011 14.8 7.9 0.014 14.4 5.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_13 PF13166.1 ESA03589.1 - 0.013 14.0 10.9 0.06 11.8 7.0 1.7 1 1 1 2 2 2 0 AAA domain SlyX PF04102.7 ESA03589.1 - 0.014 15.7 7.3 0.1 12.9 3.3 2.4 1 1 1 2 2 2 0 SlyX Vps51 PF08700.6 ESA03589.1 - 0.016 15.0 2.2 0.95 9.3 1.1 2.8 1 1 0 1 1 1 0 Vps51/Vps67 TMF_DNA_bd PF12329.3 ESA03589.1 - 0.016 14.9 13.9 0.29 10.9 5.6 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding NAP PF00956.13 ESA03589.1 - 0.016 14.3 0.8 0.021 13.9 0.5 1.3 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) Lebercilin PF15619.1 ESA03589.1 - 0.018 14.4 11.1 0.033 13.6 3.6 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Bacillus_HBL PF05791.6 ESA03589.1 - 0.022 14.1 3.4 0.041 13.2 2.3 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.3 ESA03589.1 - 0.022 14.6 12.6 0.36 10.7 8.3 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3972 PF13118.1 ESA03589.1 - 0.022 14.8 3.9 0.037 14.1 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Atg14 PF10186.4 ESA03589.1 - 0.023 13.6 12.1 0.031 13.2 8.4 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_I PF06008.9 ESA03589.1 - 0.026 13.8 6.8 0.027 13.7 2.4 1.8 1 1 1 2 2 2 0 Laminin Domain I ACCA PF03255.9 ESA03589.1 - 0.027 14.0 4.9 0.038 13.5 2.1 2.1 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Tropomyosin_1 PF12718.2 ESA03589.1 - 0.028 14.2 13.2 0.13 12.1 9.2 1.9 1 1 0 1 1 1 0 Tropomyosin like zf-C4H2 PF10146.4 ESA03589.1 - 0.043 13.8 6.1 0.052 13.5 4.2 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein FlxA PF14282.1 ESA03589.1 - 0.045 13.7 10.1 0.18 11.7 7.0 1.9 1 1 1 2 2 2 0 FlxA-like protein Nsp1_C PF05064.8 ESA03589.1 - 0.046 13.3 5.6 1.5 8.4 0.5 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region PEP-utilisers_N PF05524.8 ESA03589.1 - 0.046 13.5 2.0 0.091 12.5 1.4 1.6 2 0 0 2 2 1 0 PEP-utilising enzyme, N-terminal Laminin_II PF06009.7 ESA03589.1 - 0.051 13.3 7.2 0.067 12.9 1.8 2.1 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.3 ESA03589.1 - 0.053 13.2 12.2 0.098 12.3 8.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Pox_A_type_inc PF04508.7 ESA03589.1 - 0.062 13.1 0.6 0.062 13.1 0.4 4.0 3 2 2 5 5 2 0 Viral A-type inclusion protein repeat CCDC155 PF14662.1 ESA03589.1 - 0.062 12.8 11.0 0.1 12.1 7.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 ALMT PF11744.3 ESA03589.1 - 0.072 11.7 2.4 0.088 11.4 1.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter End3 PF12761.2 ESA03589.1 - 0.072 12.7 7.5 1.5 8.4 5.2 2.1 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 KaiC PF06745.8 ESA03589.1 - 0.075 12.1 2.3 0.11 11.6 1.6 1.2 1 0 0 1 1 1 0 KaiC DUF4140 PF13600.1 ESA03589.1 - 0.081 13.3 9.1 2.2 8.7 0.3 3.1 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2664 PF10867.3 ESA03589.1 - 0.084 13.5 1.0 0.18 12.4 0.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2664) DUF2968 PF11180.3 ESA03589.1 - 0.087 12.1 5.7 0.12 11.7 3.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) AKNA PF12443.3 ESA03589.1 - 0.091 12.7 8.4 0.16 12.0 1.2 2.5 1 1 1 2 2 2 0 AT-hook-containing transcription factor Seryl_tRNA_N PF02403.17 ESA03589.1 - 0.094 12.7 11.7 0.17 11.9 7.6 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1192 PF06698.6 ESA03589.1 - 0.098 12.4 9.8 2.9 7.7 0.6 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) Microtub_assoc PF07989.6 ESA03589.1 - 0.1 12.4 10.3 0.08 12.7 4.8 2.4 2 1 1 3 3 2 0 Microtubule associated Mnd1 PF03962.10 ESA03589.1 - 0.1 12.2 11.2 0.4 10.3 7.7 1.7 1 1 1 2 2 2 0 Mnd1 family ApoO PF09769.4 ESA03589.1 - 0.1 12.2 0.1 0.23 11.1 0.0 1.5 1 1 0 1 1 1 0 Apolipoprotein O Prefoldin_2 PF01920.15 ESA03589.1 - 0.11 12.3 11.9 1.3 8.8 2.5 2.6 1 1 1 2 2 2 0 Prefoldin subunit Reo_sigmaC PF04582.7 ESA03589.1 - 0.11 11.6 0.5 0.14 11.3 0.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF3573 PF12097.3 ESA03589.1 - 0.12 10.9 4.9 0.2 10.2 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Med9 PF07544.8 ESA03589.1 - 0.13 12.0 12.6 0.13 12.0 4.1 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4200 PF13863.1 ESA03589.1 - 0.13 12.2 14.2 0.87 9.5 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) AAA_32 PF13654.1 ESA03589.1 - 0.13 10.8 3.3 0.14 10.7 2.3 1.1 1 0 0 1 1 1 0 AAA domain DUF1049 PF06305.6 ESA03589.1 - 0.13 11.7 2.2 3.3 7.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF3450 PF11932.3 ESA03589.1 - 0.13 11.4 7.1 0.37 10.0 4.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) TSC22 PF01166.13 ESA03589.1 - 0.13 12.2 8.7 1.8 8.5 0.4 3.4 1 1 2 3 3 3 0 TSC-22/dip/bun family Phage_Mu_Gam PF07352.7 ESA03589.1 - 0.13 11.7 6.3 0.25 10.8 4.3 1.7 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein COG5 PF10392.4 ESA03589.1 - 0.15 12.0 7.2 0.22 11.4 5.0 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 FliJ PF02050.11 ESA03589.1 - 0.15 12.0 8.6 0.48 10.4 6.0 1.8 1 1 0 1 1 1 0 Flagellar FliJ protein Med21 PF11221.3 ESA03589.1 - 0.16 11.9 9.5 0.27 11.2 6.1 1.7 2 0 0 2 2 1 0 Subunit 21 of Mediator complex DUF342 PF03961.8 ESA03589.1 - 0.16 10.3 7.6 0.22 9.9 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Striatin PF08232.7 ESA03589.1 - 0.17 12.2 9.7 0.42 10.9 3.9 2.1 1 1 1 2 2 2 0 Striatin family DUF2730 PF10805.3 ESA03589.1 - 0.19 11.5 4.4 0.92 9.2 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) LMSTEN PF07988.7 ESA03589.1 - 0.19 11.0 3.8 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 LMSTEN motif Phage_GP20 PF06810.6 ESA03589.1 - 0.19 11.1 9.3 0.8 9.1 6.6 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 V-SNARE PF05008.10 ESA03589.1 - 0.21 11.7 14.9 0.47 10.6 3.9 2.5 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF972 PF06156.8 ESA03589.1 - 0.21 11.9 8.2 0.52 10.6 0.9 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF2203 PF09969.4 ESA03589.1 - 0.21 11.7 3.2 0.35 11.1 2.1 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) HAUS6_N PF14661.1 ESA03589.1 - 0.23 10.7 4.8 0.29 10.4 3.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF724 PF05266.9 ESA03589.1 - 0.24 11.0 10.9 0.58 9.7 7.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TMPIT PF07851.8 ESA03589.1 - 0.24 10.4 4.6 0.29 10.1 3.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein bZIP_2 PF07716.10 ESA03589.1 - 0.24 11.2 10.5 8 6.3 0.5 3.4 2 1 1 3 3 3 0 Basic region leucine zipper Effector_1 PF04518.7 ESA03589.1 - 0.3 10.0 4.4 0.38 9.6 3.0 1.2 1 0 0 1 1 1 0 Effector from type III secretion system ScpA_ScpB PF02616.9 ESA03589.1 - 0.3 10.6 7.2 0.39 10.2 5.0 1.1 1 0 0 1 1 1 0 ScpA/B protein YlqD PF11068.3 ESA03589.1 - 0.32 11.0 9.0 0.61 10.1 6.2 1.5 1 1 0 1 1 1 0 YlqD protein FlaC_arch PF05377.6 ESA03589.1 - 0.32 10.9 8.3 3.5 7.5 0.3 3.3 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Spc24 PF08286.6 ESA03589.1 - 0.32 10.6 8.4 7.8 6.2 5.8 2.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CCDC-167 PF15188.1 ESA03589.1 - 0.38 10.7 14.4 0.73 9.8 6.2 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Tropomyosin PF00261.15 ESA03589.1 - 0.4 9.7 14.9 0.79 8.7 10.3 1.4 1 1 0 1 1 1 0 Tropomyosin Paralemmin PF03285.10 ESA03589.1 - 0.46 9.9 9.9 2.8 7.3 3.8 2.0 1 1 1 2 2 2 0 Paralemmin DUF3375 PF11855.3 ESA03589.1 - 0.48 9.1 5.2 0.75 8.4 3.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3375) DUF904 PF06005.7 ESA03589.1 - 0.51 10.6 12.0 2.7 8.3 8.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF1664 PF07889.7 ESA03589.1 - 0.51 10.1 5.5 4 7.2 3.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Rop-like PF05082.8 ESA03589.1 - 0.55 9.7 4.8 0.31 10.5 0.5 2.5 3 0 0 3 3 2 0 Rop-like Fib_alpha PF08702.5 ESA03589.1 - 0.61 10.2 10.4 2.1 8.4 6.7 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Macoilin PF09726.4 ESA03589.1 - 0.7 8.1 9.3 0.87 7.7 6.4 1.1 1 0 0 1 1 1 0 Transmembrane protein Cob_adeno_trans PF01923.13 ESA03589.1 - 0.72 9.6 5.6 2.4 7.9 1.0 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Val_tRNA-synt_C PF10458.4 ESA03589.1 - 0.73 9.9 7.1 5.3 7.1 0.2 3.2 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm Lzipper-MIP1 PF14389.1 ESA03589.1 - 0.77 9.9 9.3 0.9 9.6 0.6 3.0 1 1 2 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF3373 PF11853.3 ESA03589.1 - 0.81 8.1 7.6 1.8 6.9 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3373) DUF3251 PF11622.3 ESA03589.1 - 0.81 9.0 3.7 2.7 7.3 0.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3251) GrpE PF01025.14 ESA03589.1 - 0.88 9.1 8.5 1.8 8.1 2.6 2.2 1 1 1 2 2 2 0 GrpE Prefoldin PF02996.12 ESA03589.1 - 0.88 9.2 9.0 11 5.6 2.1 2.9 1 1 3 4 4 4 0 Prefoldin subunit CALCOCO1 PF07888.6 ESA03589.1 - 0.89 7.7 12.3 0.23 9.7 2.5 1.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like IFT46_B_C PF12317.3 ESA03589.1 - 0.9 8.8 3.5 1.6 8.0 2.1 1.6 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal TMCO5 PF14992.1 ESA03589.1 - 1 8.4 10.9 1.6 7.7 7.6 1.3 1 0 0 1 1 1 0 TMCO5 family GLE1 PF07817.8 ESA03589.1 - 1.1 8.1 4.3 0.69 8.8 1.6 1.6 1 1 1 2 2 2 0 GLE1-like protein Ax_dynein_light PF10211.4 ESA03589.1 - 1.2 8.9 12.4 0.9 9.3 6.6 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain Kinetocho_Slk19 PF12709.2 ESA03589.1 - 1.3 9.1 8.0 82 3.3 4.4 2.7 1 1 1 2 2 2 0 Central kinetochore-associated DUF2407_C PF13373.1 ESA03589.1 - 1.4 8.8 7.3 1.6 8.6 1.2 2.7 1 1 2 3 3 3 0 DUF2407 C-terminal domain Med4 PF10018.4 ESA03589.1 - 1.4 8.2 9.0 3.2 7.1 6.2 1.7 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 FemAB PF02388.11 ESA03589.1 - 1.5 7.4 5.3 2 7.0 3.7 1.2 1 0 0 1 1 1 0 FemAB family DUF4404 PF14357.1 ESA03589.1 - 2 8.8 10.7 0.26 11.7 4.0 2.1 2 1 1 3 3 2 0 Domain of unknown function (DUF4404) DUF496 PF04363.7 ESA03589.1 - 2.1 8.2 7.0 0.51 10.1 0.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF496) bZIP_1 PF00170.16 ESA03589.1 - 2.2 8.2 11.9 0.7 9.9 3.2 2.7 2 1 1 3 3 2 0 bZIP transcription factor DUF1640 PF07798.6 ESA03589.1 - 2.2 8.2 8.1 3.8 7.5 5.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Bap31 PF05529.7 ESA03589.1 - 2.3 7.6 7.9 8.1 5.8 5.4 2.0 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like Tnp_P_element PF12017.3 ESA03589.1 - 2.6 7.2 5.0 2.1 7.5 2.2 1.8 1 1 1 2 2 2 0 Transposase protein Syntaxin-6_N PF09177.6 ESA03589.1 - 3.1 8.2 10.0 41 4.6 7.0 2.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal XhlA PF10779.4 ESA03589.1 - 3.3 7.6 12.1 6.9 6.6 1.2 2.7 1 1 1 2 2 2 0 Haemolysin XhlA Syntaxin PF00804.20 ESA03589.1 - 4.3 7.5 13.7 9.7 6.4 0.8 2.7 1 1 1 2 2 2 0 Syntaxin DUF4164 PF13747.1 ESA03589.1 - 4.5 7.4 10.7 1.8 8.7 3.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF947 PF06102.7 ESA03589.1 - 4.7 7.0 9.6 1.6 8.5 3.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF947) DUF641 PF04859.7 ESA03589.1 - 5 6.8 8.6 22 4.8 1.8 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Uds1 PF15456.1 ESA03589.1 - 5.7 6.9 12.2 11 6.0 4.1 2.7 1 1 2 3 3 3 0 Up-regulated During Septation DUF465 PF04325.8 ESA03589.1 - 6.1 6.6 7.9 43 3.9 4.7 2.7 1 1 1 2 2 1 0 Protein of unknown function (DUF465) Clusterin PF01093.12 ESA03592.1 - 0.057 12.2 0.4 0.07 11.9 0.3 1.1 1 0 0 1 1 1 0 Clusterin DUF669 PF05037.8 ESA03595.1 - 0.0022 17.8 0.3 0.0029 17.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF669) RabGAP-TBC PF00566.13 ESA03595.1 - 0.051 13.0 2.6 0.065 12.7 1.8 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain ORC4_C PF14629.1 ESA03596.1 - 0.073 12.4 0.8 0.12 11.7 0.3 1.5 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 4 C-terminus Sel1 PF08238.7 ESA03597.1 - 8e-25 86.7 4.8 1.4e-12 47.8 0.3 4.2 4 0 0 4 4 4 2 Sel1 repeat Pkinase_Tyr PF07714.12 ESA03597.1 - 0.001 18.2 0.3 0.0083 15.2 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase TPR_12 PF13424.1 ESA03597.1 - 0.18 11.7 0.4 23 5.0 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03597.1 - 1.9 8.2 6.6 7.3 6.3 0.8 3.1 2 1 1 3 3 3 0 TPR repeat HSF_DNA-bind PF00447.12 ESA03601.1 - 2.3e-35 120.8 1.7 2.3e-35 120.8 1.2 2.1 2 1 0 2 2 2 1 HSF-type DNA-binding DEAD PF00270.24 ESA03602.1 - 2.1e-39 134.6 1.8 7.6e-39 132.8 0.5 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA03602.1 - 1.7e-17 63.0 0.0 4.5e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESA03602.1 - 3.1e-06 26.1 0.7 1.1e-05 24.4 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.10 ESA03602.1 - 3.3e-06 27.0 0.1 1.2e-05 25.1 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESA03602.1 - 0.0083 16.2 0.6 0.21 11.7 0.3 2.8 2 1 0 2 2 2 1 AAA domain Tub PF01167.13 ESA03603.1 - 0.082 11.8 0.2 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 Tub family Alginate_lyase PF05426.7 ESA03604.1 - 3.8e-08 33.0 0.0 6.9e-07 28.8 0.0 2.5 2 0 0 2 2 2 1 Alginate lyase PRMT5 PF05185.11 ESA03605.1 - 8.6e-09 34.8 0.3 1.3e-08 34.2 0.2 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.1 ESA03605.1 - 1e-06 28.4 0.7 2.2e-06 27.3 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 ESA03605.1 - 1.2e-06 27.8 0.1 2.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 ESA03605.1 - 7.9e-06 26.4 0.0 2.7e-05 24.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain zf-C2H2_2 PF12756.2 ESA03605.1 - 1.1e-05 25.4 2.2 8.3e-05 22.6 1.3 2.4 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Methyltransf_11 PF08241.7 ESA03605.1 - 0.00071 20.0 0.0 0.0027 18.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA03605.1 - 0.0036 17.3 0.0 0.0079 16.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain zf-Di19 PF05605.7 ESA03605.1 - 0.39 10.8 3.3 0.69 10.0 2.3 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PGM_PMM_I PF02878.11 ESA03606.1 - 2e-35 121.3 0.0 3.2e-35 120.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 ESA03606.1 - 4.3e-27 94.3 0.0 7.3e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 ESA03606.1 - 1.3e-15 57.5 0.1 6.6e-15 55.3 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 ESA03606.1 - 2.6e-11 43.3 0.0 7.1e-11 41.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain SMC_N PF02463.14 ESA03607.1 - 1.8e-60 203.9 32.1 2e-59 200.4 22.3 2.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 ESA03607.1 - 2.5e-22 79.1 1.0 1.9e-21 76.2 0.1 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 ESA03607.1 - 2e-18 67.4 3.8 2e-18 67.4 2.6 7.2 1 1 2 4 4 4 1 AAA domain AAA_21 PF13304.1 ESA03607.1 - 1.1e-09 38.7 29.1 2.7e-05 24.2 0.1 4.9 3 1 1 4 4 4 2 AAA domain AAA_29 PF13555.1 ESA03607.1 - 3.4e-05 23.2 0.0 9.1e-05 21.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain WEMBL PF05701.6 ESA03607.1 - 0.00031 19.3 45.9 0.00031 19.3 31.8 4.9 3 2 1 4 4 4 1 Weak chloroplast movement under blue light Reo_sigmaC PF04582.7 ESA03607.1 - 0.00039 19.6 7.5 0.00039 19.6 5.2 5.0 4 1 1 5 5 5 3 Reovirus sigma C capsid protein ABC_tran PF00005.22 ESA03607.1 - 0.36 11.1 0.0 0.36 11.1 0.0 6.4 3 2 0 3 3 3 0 ABC transporter Pilin_PilA PF14245.1 ESA03607.1 - 0.48 10.9 6.6 6.1 7.3 0.6 3.9 2 1 1 3 3 3 0 Type IV pilin PilA TPR_11 PF13414.1 ESA03608.1 - 4e-10 39.1 5.3 0.0037 16.8 0.0 3.4 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 ESA03608.1 - 3.7e-09 35.7 0.8 0.023 14.3 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA03608.1 - 4.9e-09 35.4 4.2 0.042 13.7 0.2 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA03608.1 - 3.5e-07 29.9 1.1 0.56 10.5 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA03608.1 - 1.5e-06 28.4 1.7 0.011 16.0 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA03608.1 - 4.7e-06 25.9 1.0 4.9 7.1 0.1 5.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03608.1 - 8e-06 25.7 6.8 0.0041 17.0 0.6 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA03608.1 - 1.3e-05 25.7 7.7 0.0013 19.3 0.0 4.0 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA03608.1 - 2.4e-05 24.5 4.2 1.4 9.7 0.1 4.6 2 1 3 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA03608.1 - 0.00066 19.7 2.7 0.48 10.5 0.1 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESA03608.1 - 0.00093 18.8 6.1 0.34 10.8 0.1 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat DUF3366 PF11846.3 ESA03608.1 - 0.0016 18.3 1.4 0.013 15.3 0.2 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF3366) zf-C2H2 PF00096.21 ESA03610.1 - 0.026 14.8 0.1 0.081 13.3 0.1 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA03610.1 - 0.061 13.6 0.1 0.22 11.9 0.1 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA03613.1 - 0.0027 17.9 1.4 0.0084 16.3 1.0 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 ESA03613.1 - 0.043 14.0 0.6 0.093 12.9 0.4 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA03613.1 - 0.16 11.9 1.3 0.29 11.0 0.9 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger OTU PF02338.14 ESA03614.1 - 0.00052 20.5 0.0 0.0013 19.2 0.0 1.7 1 1 1 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESA03614.1 - 0.0037 16.6 0.2 0.0061 15.9 0.1 1.4 1 1 0 1 1 1 1 Peptidase C65 Otubain Herpes_ori_bp PF02399.10 ESA03615.1 - 9.7e-07 27.1 0.1 0.0018 16.3 0.0 2.1 1 1 1 2 2 2 2 Origin of replication binding protein DUF4327 PF14217.1 ESA03618.1 - 0.0022 17.7 0.2 0.12 12.2 0.0 2.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4327) DUF3557 PF12078.3 ESA03619.1 - 0.019 14.7 0.0 0.044 13.5 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3557) LRR_4 PF12799.2 ESA03619.1 - 0.73 9.5 8.8 0.94 9.1 2.4 3.3 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) PB1 PF00564.19 ESA03621.1 - 9.2e-14 50.8 0.0 1.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 PB1 domain TPR_11 PF13414.1 ESA03621.1 - 1.4e-10 40.6 0.0 5.4e-07 29.1 0.0 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA03621.1 - 8.6e-08 31.4 1.4 0.0063 16.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA03621.1 - 2.8e-06 26.8 1.1 0.039 13.8 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA03621.1 - 0.00012 22.0 0.0 0.021 14.9 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03621.1 - 0.022 14.6 0.2 0.054 13.4 0.1 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA03621.1 - 0.06 13.8 0.0 24 5.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA03621.1 - 0.26 11.1 7.5 4.1 7.4 0.0 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF1682 PF07946.9 ESA03622.1 - 0.0088 14.9 0.7 0.011 14.6 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF1863 PF08937.6 ESA03624.1 - 2.7 8.0 7.6 3 7.8 0.4 2.7 2 1 1 3 3 3 0 MTH538 TIR-like domain (DUF1863) DNA_pol_B PF00136.16 ESA03625.1 - 1.5e-20 73.4 0.8 4.9e-20 71.7 0.6 1.7 1 1 0 1 1 1 1 DNA polymerase family B PolyA_pol_RNAbd PF12627.2 ESA03625.1 - 0.098 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A DNA_pol_B PF00136.16 ESA03626.1 - 5.6e-35 121.0 2.3 1.5e-32 112.9 1.6 2.1 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B PF00136.16 ESA03627.1 - 3.5e-05 22.7 1.0 8.5e-05 21.5 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase family B CENP-B_dimeris PF09026.5 ESA03627.1 - 0.14 12.4 5.8 0.093 12.9 1.8 2.3 2 1 0 2 2 2 0 Centromere protein B dimerisation domain DUF4611 PF15387.1 ESA03627.1 - 0.45 10.6 7.2 1.6 8.9 4.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) SPRY PF00622.23 ESA03628.1 - 2.3e-12 47.0 0.3 2.6e-12 46.9 0.2 1.0 1 0 0 1 1 1 1 SPRY domain DUF4275 PF14101.1 ESA03629.1 - 0.013 15.5 5.8 0.26 11.3 1.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4275) SPRY PF00622.23 ESA03630.1 - 9.8e-11 41.8 0.3 1.1e-10 41.6 0.2 1.0 1 0 0 1 1 1 1 SPRY domain TLD PF07534.11 ESA03631.1 - 0.0019 18.2 1.6 0.0023 17.9 1.1 1.1 1 0 0 1 1 1 1 TLD Eno-Rase_FAD_bd PF07055.7 ESA03631.1 - 0.3 11.0 3.2 0.2 11.6 1.0 1.7 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Bromo_MP PF01573.11 ESA03632.1 - 0.06 12.3 2.8 0.075 12.0 1.9 1.1 1 0 0 1 1 1 0 Bromovirus movement protein TIMELESS_C PF05029.8 ESA03632.1 - 0.1 11.5 6.3 0.11 11.4 4.4 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region SRP-alpha_N PF04086.8 ESA03632.1 - 4.9 6.4 14.6 5.6 6.2 10.2 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal HMG_box PF00505.14 ESA03633.1 - 1.8e-21 76.1 2.6 2.1e-21 75.9 1.8 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA03633.1 - 7.6e-15 55.0 2.5 8.5e-15 54.8 1.7 1.0 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 ESA03633.1 - 0.0032 17.2 0.5 0.0037 17.0 0.4 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box 5 CHDNT PF08073.7 ESA03633.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 CHDNT (NUC034) domain RE_HindIII PF09518.5 ESA03633.1 - 0.075 11.9 0.5 0.083 11.7 0.4 1.0 1 0 0 1 1 1 0 HindIII restriction endonuclease MutS_V PF00488.16 ESA03634.1 - 2e-58 197.5 0.1 1.2e-57 195.0 0.1 2.2 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESA03634.1 - 1.2e-31 110.1 0.4 2.9e-31 108.8 0.3 1.6 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.13 ESA03634.1 - 7.4e-07 29.2 0.0 4.2e-06 26.8 0.0 2.5 1 0 0 1 1 1 1 MutS family domain IV SPRY PF00622.23 ESA03635.1 - 1.4e-11 44.5 0.1 1.5e-11 44.4 0.1 1.0 1 0 0 1 1 1 1 SPRY domain SPRY PF00622.23 ESA03637.1 - 1e-15 57.8 0.5 1.2e-15 57.7 0.3 1.0 1 0 0 1 1 1 1 SPRY domain UQ_con PF00179.21 ESA03642.1 - 8.8e-26 90.0 0.0 9.9e-26 89.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA03642.1 - 0.094 12.6 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain Cu-oxidase PF00394.17 ESA03643.1 - 3e-38 131.2 0.0 2.2e-37 128.3 0.0 2.3 2 1 1 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA03643.1 - 1.3e-33 115.4 1.6 3.8e-33 113.9 1.2 1.6 2 0 0 2 2 2 1 Multicopper oxidase WD40 PF00400.27 ESA03647.1 - 1.4e-69 227.7 38.2 4.5e-13 48.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 ESA03647.1 - 1.5e-07 31.3 0.7 0.00065 19.4 0.0 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 ESA03647.1 - 0.0003 20.2 0.0 2.2 7.8 0.0 3.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 ESA03647.1 - 0.00095 17.1 5.2 0.015 13.1 2.1 2.4 1 1 1 2 2 2 2 IKI3 family Ig_2 PF13895.1 ESA03647.1 - 0.0074 16.3 0.1 0.058 13.5 0.0 2.4 2 1 1 3 3 3 1 Immunoglobulin domain Nucleoporin_N PF08801.6 ESA03647.1 - 0.012 14.3 2.7 0.1 11.2 0.0 3.1 2 1 1 3 3 3 0 Nup133 N terminal like SUKH_6 PF14568.1 ESA03647.1 - 0.026 15.0 1.0 0.069 13.6 0.6 1.9 1 1 0 1 1 1 0 SMI1-KNR4 cell-wall Coatomer_WDAD PF04053.9 ESA03647.1 - 0.19 10.5 1.3 2.1 7.0 0.1 2.6 2 1 1 3 3 3 0 Coatomer WD associated region Ribosomal_S30 PF04758.9 ESA03648.1 - 2.5e-28 97.5 9.7 2.7e-28 97.4 6.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 DUF3746 PF12562.3 ESA03648.1 - 0.12 12.2 0.6 0.17 11.7 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) TFIIB PF00382.14 ESA03649.1 - 9.1e-43 143.9 4.7 5e-24 83.9 0.6 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 ESA03649.1 - 1.3e-15 56.3 1.3 2.1e-15 55.7 0.9 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.14 ESA03649.1 - 2.3e-05 24.2 0.3 0.0045 16.9 0.1 2.3 1 1 1 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.18 ESA03649.1 - 0.0001 21.8 2.7 0.00071 19.1 0.1 2.4 1 1 1 2 2 2 1 Cyclin, N-terminal domain Rrf2 PF02082.15 ESA03649.1 - 0.085 12.9 0.0 23 5.2 0.0 2.5 2 0 0 2 2 2 0 Transcriptional regulator Sigma70_r4_2 PF08281.7 ESA03649.1 - 0.1 12.1 0.9 0.31 10.5 0.0 2.3 3 0 0 3 3 3 0 Sigma-70, region 4 Nudix_N_2 PF14803.1 ESA03649.1 - 0.15 11.7 0.6 4.2 7.1 0.0 2.6 2 0 0 2 2 2 0 Nudix N-terminal A2L_zn_ribbon PF08792.5 ESA03649.1 - 0.27 10.7 1.8 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 A2L zinc ribbon domain Vps26 PF03643.10 ESA03650.1 - 1.1e-128 427.8 3.3 1.3e-128 427.6 2.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 ESA03650.1 - 0.0024 17.6 1.8 0.69 9.7 0.0 3.4 3 1 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain FAD_binding_1 PF00667.15 ESA03651.1 - 1.7e-54 184.5 0.1 2.5e-54 184.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 ESA03651.1 - 5.9e-33 113.8 0.0 1.1e-32 112.9 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 ESA03651.1 - 1.7e-15 57.5 0.0 3.5e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.2 ESA03651.1 - 8e-05 22.6 0.0 0.0088 16.0 0.0 2.8 1 1 1 2 2 2 2 Flavodoxin domain Flavodoxin_3 PF12641.2 ESA03651.1 - 0.00015 21.2 0.0 0.0058 16.0 0.0 2.4 2 0 0 2 2 2 1 Flavodoxin domain Ribosomal_L13e PF01294.13 ESA03652.1 - 2.4e-77 258.4 7.9 3.3e-77 258.0 5.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e DUF3959 PF13105.1 ESA03652.1 - 0.092 12.0 0.5 0.13 11.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) DUF2817 PF10994.3 ESA03653.1 - 1.8 7.5 3.8 2.1 7.3 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) WD40 PF00400.27 ESA03654.1 - 1.1e-09 37.7 0.2 4.2e-09 35.9 0.1 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat TPR_11 PF13414.1 ESA03656.1 - 3.3e-23 81.1 1.4 1.1e-15 56.9 0.1 2.2 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA03656.1 - 2.2e-14 52.3 1.1 1.7e-05 24.2 0.0 3.4 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA03656.1 - 2.5e-10 39.4 0.6 0.0012 18.5 0.0 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03656.1 - 3.9e-08 33.1 0.0 7.4e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA03656.1 - 3.2e-06 26.5 0.0 0.047 13.4 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA03656.1 - 6.3e-06 26.3 0.0 0.074 13.7 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA03656.1 - 1.4e-05 24.4 0.4 0.027 14.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF1351 PF07083.6 ESA03656.1 - 0.00083 19.0 0.3 0.00083 19.0 0.2 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1351) TPR_16 PF13432.1 ESA03656.1 - 0.001 19.6 0.3 0.018 15.7 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA03656.1 - 0.0034 17.4 3.6 0.075 13.1 0.3 1.8 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA03656.1 - 0.0045 17.2 0.1 0.025 14.8 0.1 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat HHH_8 PF14716.1 ESA03656.1 - 0.013 15.6 0.9 0.22 11.7 0.1 2.7 2 1 0 2 2 2 0 Helix-hairpin-helix domain TPR_17 PF13431.1 ESA03656.1 - 0.016 15.3 0.2 2.1 8.7 0.0 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF2225 PF09986.4 ESA03656.1 - 0.053 12.9 1.7 0.089 12.2 1.2 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) DASH_Dad3 PF08656.5 ESA03656.1 - 0.066 12.9 0.1 0.39 10.4 0.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad3 TPR_9 PF13371.1 ESA03656.1 - 0.16 11.8 0.0 8.2 6.3 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 ESA03656.1 - 0.17 11.8 0.9 4.8 7.1 0.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain HTH_32 PF13565.1 ESA03656.1 - 0.31 11.8 1.4 0.62 10.8 0.1 2.2 2 1 1 3 3 2 0 Homeodomain-like domain RPN7 PF10602.4 ESA03656.1 - 0.68 9.2 3.7 3.1 7.1 1.6 2.5 1 1 1 2 2 2 0 26S proteasome subunit RPN7 Enkurin PF13864.1 ESA03656.1 - 0.75 10.0 6.7 7.4 6.8 0.0 2.8 3 0 0 3 3 3 0 Calmodulin-binding E1_dh PF00676.15 ESA03657.1 - 7.8e-116 385.9 0.4 9.3e-116 385.7 0.2 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 ESA03657.1 - 0.0017 17.3 0.0 0.003 16.5 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_N PF00456.16 ESA03657.1 - 0.1 11.3 0.1 0.14 10.9 0.0 1.3 1 1 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain F-box PF00646.28 ESA03658.1 - 5e-09 35.5 0.8 1.4e-08 34.1 0.6 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA03658.1 - 2e-08 33.8 2.6 5.1e-08 32.5 1.8 1.7 1 0 0 1 1 1 1 F-box-like YccV-like PF08755.6 ESA03658.1 - 0.0022 17.8 0.0 0.0062 16.4 0.0 1.8 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Elongin_A PF06881.6 ESA03658.1 - 0.025 14.9 1.2 0.025 14.9 0.9 2.3 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Transglut_core2 PF13369.1 ESA03658.1 - 0.094 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily Ras PF00071.17 ESA03659.1 - 1e-52 177.7 0.0 1.2e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA03659.1 - 3.5e-16 59.7 0.0 4.8e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA03659.1 - 3.7e-08 32.7 0.0 4.8e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3927 PF13064.1 ESA03662.1 - 0.31 10.5 1.9 0.49 9.9 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) BTB PF00651.26 ESA03665.1 - 8.9e-19 67.5 0.1 8.9e-17 61.0 0.0 2.6 1 1 1 2 2 2 1 BTB/POZ domain DUF4358 PF14270.1 ESA03665.1 - 0.021 14.7 0.8 0.13 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) DUF4468 PF14730.1 ESA03665.1 - 0.081 12.6 0.4 0.39 10.4 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4468) with TBP-like fold HATPase_c_3 PF13589.1 ESA03666.1 - 0.039 13.6 0.1 0.2 11.3 0.0 1.9 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BTB PF00651.26 ESA03667.1 - 4.3e-17 62.1 0.2 5.5e-14 52.0 0.0 2.6 1 1 1 2 2 2 2 BTB/POZ domain Ribosomal_S25 PF03297.10 ESA03668.1 - 1.5 8.8 5.5 8.2 6.5 3.8 1.8 1 1 0 1 1 1 0 S25 ribosomal protein DUF2704 PF10866.3 ESA03669.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2704) Dimer_Tnp_hAT PF05699.9 ESA03670.1 - 6.9e-16 57.6 0.3 7.8e-16 57.4 0.2 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ctr PF04145.10 ESA03673.1 - 5.1e-08 33.0 14.4 1.2e-06 28.6 2.8 2.0 1 1 1 2 2 2 2 Ctr copper transporter family DUF1295 PF06966.7 ESA03673.1 - 0.063 12.5 1.5 0.074 12.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) DUF1724 PF08350.5 ESA03673.1 - 0.088 12.3 1.4 0.11 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) Cation_ATPase_C PF00689.16 ESA03673.1 - 1.7 8.1 6.6 2.6 7.5 4.6 1.4 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Clat_adaptor_s PF01217.15 ESA03674.1 - 1.6e-56 189.9 4.5 1.9e-56 189.7 3.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Adap_comp_sub PF00928.16 ESA03675.1 - 1.4e-52 178.3 0.8 1.8e-52 178.0 0.6 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESA03675.1 - 0.0018 17.9 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Porin_3 PF01459.17 ESA03676.1 - 1.4e-60 204.9 0.1 1.6e-60 204.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Histone PF00125.19 ESA03678.1 - 9.4e-32 108.9 0.4 1.4e-31 108.3 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA03678.1 - 7.3e-06 26.0 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA03678.1 - 0.0015 18.5 0.1 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESA03678.1 - 0.0038 16.9 0.1 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated CENP-T PF15511.1 ESA03678.1 - 0.14 11.3 1.1 0.22 10.7 0.8 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T DEAD PF00270.24 ESA03679.1 - 3.4e-46 156.8 0.0 9e-46 155.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA03679.1 - 1.5e-27 95.2 0.1 1e-26 92.5 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PP2C PF00481.16 ESA03680.1 - 7.4e-11 41.9 0.1 0.00011 21.7 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 ESA03680.1 - 1e-10 41.6 0.0 1.3e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 ESA03680.1 - 1.8e-07 30.7 0.0 2.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Elf1 PF05129.8 ESA03681.1 - 8.3e-26 89.5 1.7 1e-25 89.2 1.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-CHY PF05495.7 ESA03681.1 - 0.015 15.4 0.5 0.022 14.9 0.4 1.2 1 0 0 1 1 1 0 CHY zinc finger Cytochrome_C7 PF14522.1 ESA03681.1 - 0.032 13.8 1.3 0.051 13.2 0.9 1.3 1 0 0 1 1 1 0 Cytochrome c7 DUF678 PF05077.7 ESA03681.1 - 0.96 9.4 4.5 16 5.6 3.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF678) Syntaxin PF00804.20 ESA03682.1 - 1.2e-17 63.9 5.9 1.2e-17 63.9 4.1 2.7 3 0 0 3 3 2 1 Syntaxin SNARE PF05739.14 ESA03682.1 - 2.1e-17 62.5 0.7 2.1e-17 62.5 0.5 2.2 2 0 0 2 2 2 1 SNARE domain SlyX PF04102.7 ESA03682.1 - 0.0021 18.3 6.2 0.44 10.9 0.4 2.9 2 0 0 2 2 2 2 SlyX Sed5p PF11416.3 ESA03682.1 - 0.074 12.4 2.6 0.15 11.5 0.0 2.7 2 0 0 2 2 2 0 Integral membrane protein Sed5p DUF2421 PF10334.4 ESA03682.1 - 0.082 12.5 1.6 0.16 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2421) DUF241 PF03087.9 ESA03682.1 - 0.091 12.2 11.4 1.3 8.5 6.9 2.5 1 1 0 1 1 1 0 Arabidopsis protein of unknown function FlaC_arch PF05377.6 ESA03682.1 - 0.23 11.3 0.2 0.23 11.3 0.1 2.6 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) AKNA PF12443.3 ESA03682.1 - 0.24 11.4 6.4 6 6.9 0.1 3.1 3 1 1 4 4 3 0 AT-hook-containing transcription factor DUF1664 PF07889.7 ESA03682.1 - 0.31 10.8 9.1 0.95 9.2 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.4 ESA03682.1 - 0.31 11.0 12.3 3.2 7.7 4.4 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein NPV_P10 PF05531.7 ESA03682.1 - 0.33 11.2 14.3 0.19 12.0 1.8 4.0 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Glutaredoxin2_C PF04399.8 ESA03682.1 - 0.33 10.5 7.1 0.077 12.5 0.6 2.7 2 2 0 2 2 2 0 Glutaredoxin 2, C terminal domain Syntaxin-6_N PF09177.6 ESA03682.1 - 0.76 10.2 9.1 3.3 8.1 0.4 3.1 1 1 0 2 2 2 0 Syntaxin 6, N-terminal HrpB7 PF09486.5 ESA03682.1 - 0.86 9.5 8.4 0.17 11.7 2.7 2.1 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) IncA PF04156.9 ESA03682.1 - 1.3 8.6 13.9 0.29 10.6 2.0 2.4 1 1 1 2 2 2 0 IncA protein Spectrin PF00435.16 ESA03682.1 - 1.3 9.3 8.8 0.24 11.6 0.3 3.0 2 2 1 3 3 3 0 Spectrin repeat Adaptin_binding PF10199.4 ESA03682.1 - 1.4 9.2 7.6 2.5 8.3 5.3 1.6 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Reo_sigmaC PF04582.7 ESA03682.1 - 2.9 6.9 9.1 0.56 9.3 0.4 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein Atg14 PF10186.4 ESA03682.1 - 7.1 5.4 16.1 2.9 6.7 1.2 2.2 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1484 PF07363.6 ESA03682.1 - 9.7 6.5 9.2 2.2 8.6 0.1 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1484) Mito_carr PF00153.22 ESA03683.1 - 2.8e-74 244.9 4.9 2.7e-26 91.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 ESA03683.1 - 0.25 11.3 2.2 8.6 6.4 0.0 3.7 2 1 2 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family CHB_HEX_C_1 PF13290.1 ESA03684.1 - 0.096 12.4 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain eIF3g PF12353.3 ESA03684.1 - 0.23 11.3 6.5 0.11 12.3 1.2 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G DUF1422 PF07226.6 ESA03685.1 - 0.027 14.2 0.6 0.027 14.2 0.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1422) FixH PF05751.6 ESA03685.1 - 0.59 9.9 3.6 0.54 10.0 0.2 2.4 2 0 0 2 2 2 0 FixH Exo_endo_phos_2 PF14529.1 ESA03687.1 - 0.0011 18.5 0.2 0.0026 17.3 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA03687.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Methyltransf_28 PF02636.12 ESA03688.1 - 2.9e-70 236.5 0.0 3.5e-70 236.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase GCIP PF13324.1 ESA03690.1 - 1.4e-27 96.6 0.1 2e-27 96.0 0.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting SF-assemblin PF06705.6 ESA03690.1 - 0.038 13.1 0.3 0.062 12.4 0.2 1.4 1 0 0 1 1 1 0 SF-assemblin/beta giardin DUF2963 PF11178.3 ESA03691.1 - 0.026 13.9 3.4 1.7 8.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) TSC22 PF01166.13 ESA03691.1 - 0.031 14.2 1.6 0.031 14.2 1.1 3.4 1 1 2 3 3 3 0 TSC-22/dip/bun family TMF_DNA_bd PF12329.3 ESA03691.1 - 0.85 9.4 14.8 0.22 11.3 6.1 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Ribosomal_S13 PF00416.17 ESA03691.1 - 7.8 7.0 8.3 0.81 10.1 0.2 2.7 2 1 0 2 2 2 0 Ribosomal protein S13/S18 Mto2_bdg PF12808.2 ESA03693.1 - 0.0005 20.1 15.3 0.037 14.1 2.0 2.9 1 1 2 3 3 3 2 Micro-tubular organiser Mto1 C-term Mto2-binding region Ax_dynein_light PF10211.4 ESA03693.1 - 0.0028 17.5 11.5 0.0041 16.9 8.0 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain Zein-binding PF04576.10 ESA03693.1 - 0.0032 17.5 4.0 0.0069 16.4 2.7 1.7 1 0 0 1 1 1 1 Zein-binding DUF964 PF06133.6 ESA03693.1 - 0.019 14.9 2.2 0.019 14.9 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF964) TBPIP PF07106.8 ESA03693.1 - 0.021 14.3 7.6 0.03 13.8 5.2 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.9 ESA03693.1 - 0.053 13.1 11.8 0.074 12.6 8.2 1.1 1 0 0 1 1 1 0 IncA protein Fmp27_WPPW PF10359.4 ESA03693.1 - 0.066 11.6 3.9 0.074 11.4 2.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3373 PF11853.3 ESA03693.1 - 0.16 10.4 1.1 0.18 10.3 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF2630 PF10944.3 ESA03693.1 - 0.2 11.7 6.8 1.5 9.0 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2630) CASP_C PF08172.7 ESA03693.1 - 0.29 10.1 9.8 0.091 11.7 2.9 2.1 1 1 1 2 2 2 0 CASP C terminal KID PF02524.9 ESA03693.1 - 0.33 11.2 7.0 3.3 8.2 0.1 3.9 3 0 0 3 3 3 0 KID repeat Lipoprotein_20 PF13942.1 ESA03693.1 - 0.59 9.6 7.9 0.73 9.3 4.2 1.9 1 1 1 2 2 2 0 YfhG lipoprotein CCDC92 PF14916.1 ESA03693.1 - 0.66 9.6 6.0 2.3 7.8 0.9 2.4 2 0 0 2 2 2 0 Coiled-coil domain of unknown function COX16 PF14138.1 ESA03693.1 - 0.75 10.0 4.5 1.3 9.2 2.8 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Atg14 PF10186.4 ESA03693.1 - 0.9 8.4 7.2 1.2 8.0 5.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 ESA03693.1 - 3 6.8 11.5 3.8 6.4 8.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CENP-Q PF13094.1 ESA03693.1 - 4.7 7.2 12.5 7 6.6 8.6 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit WD40_alt PF14077.1 ESA03693.1 - 6.9 6.3 9.1 7.3 6.3 2.0 2.9 1 1 1 2 2 2 0 Alternative WD40 repeat motif HTH_Tnp_Tc3_2 PF01498.13 ESA03696.1 - 7.2e-14 51.6 2.4 1e-13 51.1 0.9 1.9 1 1 1 2 2 2 1 Transposase HTH_23 PF13384.1 ESA03696.1 - 6.4e-08 31.9 0.0 6.8e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.13 ESA03696.1 - 5e-06 26.2 0.0 6.5e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_29 PF13551.1 ESA03696.1 - 0.00037 20.6 0.1 0.013 15.6 0.0 2.5 1 1 2 3 3 3 1 Winged helix-turn helix Sigma70_r4_2 PF08281.7 ESA03696.1 - 0.0034 16.8 0.2 0.014 14.8 0.0 2.0 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_28 PF13518.1 ESA03696.1 - 0.0041 17.1 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain DUF4529 PF15032.1 ESA03696.1 - 0.0069 15.0 0.9 0.008 14.8 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4529) Terminase_5 PF06056.7 ESA03696.1 - 0.025 14.1 0.0 0.064 12.8 0.0 1.7 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_38 PF13936.1 ESA03696.1 - 0.032 13.7 0.1 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Fe_dep_repress PF01325.14 ESA03696.1 - 0.059 13.3 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.14 ESA03696.1 - 0.078 12.6 0.0 0.2 11.4 0.0 1.7 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.1 ESA03696.1 - 0.12 12.5 0.1 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain zf-C2H2_4 PF13894.1 ESA03698.1 - 0.0051 17.0 3.2 0.012 15.9 2.2 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA03698.1 - 0.14 12.5 4.0 0.31 11.4 2.8 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type SWI-SNF_Ssr4 PF08549.5 ESA03698.1 - 0.16 10.2 2.3 0.2 9.9 1.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) zf-C2H2 PF00096.21 ESA03699.1 - 0.0027 17.9 3.1 0.0027 17.9 2.1 1.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA03699.1 - 0.0076 16.5 2.2 0.016 15.5 0.9 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger DUF4567 PF15131.1 ESA03700.1 - 0.05 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4567) RecR PF02132.10 ESA03701.1 - 0.054 12.9 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 RecR protein Colicin_D PF11429.3 ESA03704.1 - 7.7e-10 38.7 2.9 1.2e-09 38.1 2.0 1.3 1 0 0 1 1 1 1 Colicin D DUF4381 PF14316.1 ESA03705.1 - 0.09 12.8 0.3 0.099 12.7 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) UPF0081 PF03652.10 ESA03705.1 - 0.12 12.5 0.0 0.12 12.4 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0081) DUF4193 PF13834.1 ESA03706.1 - 0.045 13.9 2.4 0.053 13.7 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) Herpes_UL14 PF03580.9 ESA03706.1 - 0.075 12.8 0.5 0.092 12.5 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL14-like protein Kri1 PF05178.7 ESA03706.1 - 0.51 10.6 7.2 1.2 9.4 3.7 1.9 1 1 1 2 2 2 0 KRI1-like family DUF3294 PF07957.6 ESA03708.1 - 0.00071 19.1 0.0 0.0013 18.3 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3294) IFT57 PF10498.4 ESA03708.1 - 0.013 14.2 0.7 0.022 13.5 0.3 1.4 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 MscS_porin PF12795.2 ESA03708.1 - 0.015 14.6 4.7 0.025 13.8 3.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Phage_GPO PF05929.6 ESA03708.1 - 0.022 14.0 0.1 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Baculo_PEP_C PF04513.7 ESA03708.1 - 0.038 13.8 5.6 0.054 13.3 3.9 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.1 ESA03708.1 - 0.039 14.2 4.3 0.082 13.2 3.0 1.6 1 1 0 1 1 1 0 Snapin/Pallidin EzrA PF06160.7 ESA03708.1 - 0.089 10.9 1.5 0.29 9.2 1.0 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Prominin PF05478.6 ESA03708.1 - 0.1 10.1 0.5 0.11 10.0 0.3 1.1 1 0 0 1 1 1 0 Prominin POLO_box PF00659.13 ESA03709.1 - 0.13 12.2 0.4 0.26 11.2 0.1 1.7 2 0 0 2 2 2 0 POLO box duplicated region TLD PF07534.11 ESA03710.1 - 1.1e-16 61.0 1.1 1.3e-16 60.8 0.7 1.1 1 0 0 1 1 1 1 TLD zf-BED PF02892.10 ESA03711.1 - 6.8e-06 25.7 5.4 1.3e-05 24.8 3.7 1.5 1 0 0 1 1 1 1 BED zinc finger PAP2_C PF14360.1 ESA03712.1 - 0.28 11.4 2.1 0.62 10.3 0.4 2.1 2 0 0 2 2 2 0 PAP2 superfamily C-terminal IBR PF01485.16 ESA03713.1 - 2.8e-12 46.3 21.9 4.2e-08 32.9 7.7 2.4 2 0 0 2 2 2 2 IBR domain DUF2072 PF09845.4 ESA03714.1 - 0.13 12.1 3.7 0.21 11.5 2.6 1.4 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Suf PF05843.9 ESA03714.1 - 0.63 9.7 5.3 0.69 9.5 3.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Paramyxo_NS_C PF02725.9 ESA03714.1 - 0.84 9.2 6.5 1.1 8.8 4.5 1.3 1 1 0 1 1 1 0 Non-structural protein C ERO1 PF04137.10 ESA03716.1 - 0.0049 15.9 1.1 0.0057 15.7 0.7 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) BsuPI PF12690.2 ESA03719.1 - 0.031 13.9 0.2 0.076 12.7 0.1 1.6 1 0 0 1 1 1 0 Intracellular proteinase inhibitor SF3a60_bindingd PF12108.3 ESA03719.1 - 0.033 13.7 0.9 0.082 12.4 0.6 1.8 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain RP-C_C PF11800.3 ESA03719.1 - 1.6 8.3 3.7 6.6 6.3 0.0 2.0 1 1 1 2 2 2 0 Replication protein C C-terminal region Anoctamin PF04547.7 ESA03720.1 - 1.2e-120 403.1 20.9 1.4e-120 402.9 14.5 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Med6 PF04934.9 ESA03721.1 - 2.4e-41 140.5 0.3 4.7e-41 139.6 0.2 1.5 1 0 0 1 1 1 1 MED6 mediator sub complex component Homez PF11569.3 ESA03721.1 - 0.021 13.8 0.3 9.9 5.3 0.0 3.5 3 1 1 4 4 4 0 Homeodomain leucine-zipper encoding, Homez Peptidase_S49_N PF08496.5 ESA03721.1 - 7.7 6.2 11.3 11 5.7 7.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pkinase_Tyr PF07714.12 ESA03722.1 - 7.6e-32 110.3 0.0 1.2e-31 109.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03722.1 - 1.8e-27 96.1 0.3 2.6e-27 95.6 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain YjcQ PF09639.5 ESA03722.1 - 0.057 13.5 1.8 2.6 8.2 0.1 2.4 2 1 0 2 2 2 0 YjcQ protein CHIPS PF11434.3 ESA03723.1 - 0.045 13.3 0.2 2.3 7.8 0.1 2.1 2 0 0 2 2 2 0 Chemotaxis-inhibiting protein CHIPS Cation_efflux PF01545.16 ESA03724.1 - 1.4e-28 99.8 1.0 1.6e-28 99.5 0.7 1.1 1 0 0 1 1 1 1 Cation efflux family Pkinase_Tyr PF07714.12 ESA03725.1 - 4.7e-38 130.7 0.0 6.5e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03725.1 - 1.5e-34 119.3 0.0 5.2e-34 117.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA03725.1 - 0.013 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA03725.1 - 0.048 12.7 0.1 0.26 10.3 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cyto_heme_lyase PF01265.12 ESA03726.1 - 3.5e-33 115.2 0.1 4.3e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase DUF1798 PF08807.5 ESA03726.1 - 0.058 13.1 0.1 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) UPF0184 PF03670.8 ESA03726.1 - 0.13 12.5 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF4603 PF15376.1 ESA03727.1 - 0.021 12.0 8.3 0.028 11.6 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF605 PF04652.11 ESA03727.1 - 0.043 13.2 17.1 0.056 12.8 11.8 1.1 1 0 0 1 1 1 0 Vta1 like SlyX PF04102.7 ESA03727.1 - 0.17 12.2 2.1 2.3 8.6 0.1 2.9 2 1 0 2 2 2 0 SlyX Macoilin PF09726.4 ESA03727.1 - 0.27 9.4 14.2 0.33 9.1 9.8 1.1 1 0 0 1 1 1 0 Transmembrane protein DNA_pol_viral_N PF00242.12 ESA03727.1 - 0.42 9.5 17.5 0.64 8.9 12.1 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain CDC45 PF02724.9 ESA03727.1 - 0.72 7.8 7.2 0.89 7.5 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.6 ESA03727.1 - 8.5 4.5 13.0 12 4.1 9.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF4551 PF15087.1 ESA03727.1 - 9.7 4.4 14.5 13 4.0 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Zip PF02535.17 ESA03730.1 - 9.3e-27 93.8 10.7 1.1e-26 93.6 6.9 1.5 2 0 0 2 2 2 1 ZIP Zinc transporter SID-1_RNA_chan PF13965.1 ESA03730.1 - 0.02 13.0 0.4 0.02 13.0 0.3 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 E1-E2_ATPase PF00122.15 ESA03730.1 - 2.1 7.2 6.6 0.31 10.0 0.1 2.8 3 1 0 3 3 3 0 E1-E2 ATPase VHS PF00790.14 ESA03736.1 - 0.016 14.8 0.1 0.021 14.4 0.0 1.1 1 0 0 1 1 1 0 VHS domain Ribosomal_S3Ae PF01015.13 ESA03736.1 - 0.023 14.0 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 Ribosomal S3Ae family Cluap1 PF10234.4 ESA03736.1 - 0.033 13.3 0.0 0.035 13.3 0.0 1.0 1 0 0 1 1 1 0 Clusterin-associated protein-1 Med26 PF08711.6 ESA03736.1 - 0.22 11.0 0.9 13 5.4 0.0 2.7 3 0 0 3 3 3 0 TFIIS helical bundle-like domain DivIC PF04977.10 ESA03737.1 - 0.99 8.9 11.3 1.7 8.1 2.2 2.8 2 0 0 2 2 2 0 Septum formation initiator V_ATPase_I PF01496.14 ESA03737.1 - 2.8 5.6 6.1 3.6 5.3 4.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TIP120 PF08623.5 ESA03739.1 - 1.2e-57 194.1 0.2 1.2e-57 194.1 0.2 4.9 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 ESA03739.1 - 9.4e-18 64.2 7.5 0.053 13.8 0.0 8.7 6 2 2 8 8 8 4 HEAT repeats HEAT_EZ PF13513.1 ESA03739.1 - 6.9e-14 51.8 16.6 1.7 9.2 0.0 12.3 11 4 2 13 13 13 2 HEAT-like repeat HEAT PF02985.17 ESA03739.1 - 6.4e-10 38.2 21.5 1 9.6 0.0 13.7 15 0 0 15 15 15 1 HEAT repeat DUF1546 PF07571.8 ESA03739.1 - 1.3e-05 25.2 0.7 3.2 7.9 0.0 5.0 5 0 0 5 5 5 2 Protein of unknown function (DUF1546) UME PF08064.8 ESA03739.1 - 0.00036 20.4 9.1 1.7 8.6 0.0 6.7 6 2 2 8 8 8 1 UME (NUC010) domain Vac14_Fab1_bd PF12755.2 ESA03739.1 - 0.0007 19.9 4.8 15 6.0 0.1 7.4 7 3 2 9 9 9 0 Vacuolar 14 Fab1-binding region CDC45 PF02724.9 ESA03739.1 - 0.005 14.9 2.7 0.0083 14.2 1.9 1.2 1 0 0 1 1 1 1 CDC45-like protein RRN3 PF05327.6 ESA03739.1 - 0.0099 14.0 1.1 0.028 12.5 0.8 1.8 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 ESA03739.1 - 0.019 12.9 3.9 0.045 11.6 2.7 1.7 1 0 0 1 1 1 0 Nop14-like family CinA PF02464.12 ESA03740.1 - 5.1e-52 175.4 0.1 5.7e-52 175.2 0.1 1.0 1 0 0 1 1 1 1 Competence-damaged protein Osmo_MPGsynth PF09488.5 ESA03740.1 - 0.059 12.0 0.0 0.066 11.8 0.0 1.1 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) AAA_14 PF13173.1 ESA03741.1 - 0.007 16.2 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Methyltransf_7 PF03492.10 ESA03741.1 - 0.014 14.1 0.1 0.023 13.4 0.1 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase AAA_18 PF13238.1 ESA03741.1 - 0.021 15.1 0.2 4.6 7.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 ESA03741.1 - 0.056 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FANCI_S4 PF14678.1 ESA03742.1 - 0.042 12.9 0.1 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 FANCI solenoid 4 MRG PF05712.8 ESA03742.1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.3 1 1 0 1 1 1 0 MRG DUF4041 PF13250.1 ESA03743.1 - 0.0019 17.7 0.3 0.0024 17.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4041) DUF2312 PF10073.4 ESA03743.1 - 0.13 11.6 0.2 0.24 10.7 0.1 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Ribosomal_L22 PF00237.14 ESA03744.1 - 4.9e-21 74.6 0.1 7.2e-21 74.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Aconitase PF00330.15 ESA03745.1 - 6.9e-162 539.1 0.1 3.1e-161 536.9 0.0 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 ESA03745.1 - 9.1e-42 142.2 0.0 1.7e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 ESA03745.1 - 0.11 11.0 0.0 0.31 9.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF521) TSC22 PF01166.13 ESA03746.1 - 0.00057 19.7 8.8 0.0012 18.7 4.7 2.5 2 1 0 2 2 2 1 TSC-22/dip/bun family TPR_MLP1_2 PF07926.7 ESA03746.1 - 0.005 16.5 5.3 0.005 16.5 3.7 2.0 3 0 0 3 3 3 1 TPR/MLP1/MLP2-like protein DivIC PF04977.10 ESA03746.1 - 0.0054 16.2 3.3 0.013 14.9 2.3 1.7 1 0 0 1 1 1 1 Septum formation initiator DUF4472 PF14739.1 ESA03746.1 - 0.13 12.6 8.5 1.9 8.9 4.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Ndc1_Nup PF09531.5 ESA03746.1 - 0.39 9.0 8.4 0.43 8.9 5.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PA26 PF04636.8 ESA03746.1 - 3.4 6.2 7.1 4.4 5.8 4.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PRP1_N PF06424.7 ESA03746.1 - 3.4 7.9 13.5 1.6 9.0 3.8 2.3 1 1 1 2 2 2 0 PRP1 splicing factor, N-terminal IncA PF04156.9 ESA03746.1 - 4.1 6.9 10.7 5.6 6.5 7.4 1.4 1 1 0 1 1 1 0 IncA protein bZIP_2 PF07716.10 ESA03746.1 - 6.5 6.6 14.3 7.4 6.4 6.1 3.2 2 1 0 2 2 2 0 Basic region leucine zipper Pox_A_type_inc PF04508.7 ESA03746.1 - 6.9 6.7 8.6 0.33 10.8 1.0 2.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF972 PF06156.8 ESA03746.1 - 8.5 6.7 10.3 14 6.0 6.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ESA03746.1 - 9.8 6.5 11.8 0.7 10.2 4.2 2.2 3 1 0 3 3 3 0 Protein of unknown function (DUF904) PIF1 PF05970.9 ESA03750.1 - 4.4e-15 55.5 0.1 7.2e-15 54.7 0.1 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 ESA03750.1 - 3.4e-08 33.2 0.0 5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA03750.1 - 3.7e-06 26.5 0.0 7.4e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 ESA03750.1 - 0.011 15.6 0.4 0.017 14.9 0.3 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 ESA03750.1 - 0.012 14.8 0.6 0.23 10.7 0.0 2.6 2 2 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 ESA03750.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.1 ESA03750.1 - 0.068 11.7 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Gemini_AL1_M PF08283.6 ESA03750.1 - 0.31 10.8 4.3 2.9 7.7 0.2 2.5 2 0 0 2 2 2 0 Geminivirus rep protein central domain DUF4116 PF13475.1 ESA03751.1 - 0.16 11.4 2.5 3.4 7.2 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4116) E2F_TDP PF02319.15 ESA03752.1 - 0.066 12.7 1.2 2.3 7.8 0.1 2.8 2 1 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain FBA_2 PF07735.12 ESA03754.1 - 0.12 12.1 0.5 0.15 11.9 0.3 1.2 1 0 0 1 1 1 0 F-box associated Pkinase_Tyr PF07714.12 ESA03756.1 - 8.4e-05 21.7 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03756.1 - 0.011 14.9 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Baculo_gp41 PF04700.7 ESA03756.1 - 0.073 12.5 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region HTH_Tnp_Tc5 PF03221.11 ESA03757.1 - 0.0022 17.7 0.1 0.0041 16.9 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA03757.1 - 0.017 14.2 0.0 0.054 12.6 0.0 1.7 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_1 PF03184.14 ESA03758.1 - 1.8e-47 161.2 0.0 1.9e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease FAM196 PF15265.1 ESA03759.1 - 0.0075 15.5 1.6 0.0098 15.1 1.1 1.1 1 0 0 1 1 1 1 FAM196 family RRM_1 PF00076.17 ESA03759.1 - 0.04 13.5 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIID-31kDa PF02291.10 ESA03760.1 - 5e-50 168.6 0.2 6.7e-50 168.1 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.1 ESA03760.1 - 1.1e-05 25.5 0.1 1.7e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 ESA03760.1 - 1.4e-05 24.7 0.0 2.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.19 ESA03760.1 - 0.00071 19.6 0.1 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_30kDa PF03540.8 ESA03760.1 - 0.0026 17.5 0.1 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit TFIID_20kDa PF03847.8 ESA03760.1 - 0.025 14.8 0.2 0.073 13.3 0.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A TAF PF02969.12 ESA03760.1 - 0.082 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF4565 PF15127.1 ESA03760.1 - 0.1 12.9 0.1 0.22 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4565) CKS PF01111.14 ESA03761.1 - 1.3e-30 104.9 1.2 1.3e-30 104.9 0.8 2.3 3 1 0 3 3 3 1 Cyclin-dependent kinase regulatory subunit TFIIA PF03153.8 ESA03761.1 - 2 8.2 35.6 3.5 7.4 24.7 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.11 ESA03761.1 - 8.6 6.1 18.8 12 5.6 13.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA PF00004.24 ESA03762.1 - 6.8e-16 58.6 0.1 1.9e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 ESA03762.1 - 6.2e-13 48.5 0.1 1.9e-12 46.9 0.0 1.9 1 1 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 ESA03762.1 - 4.5e-12 45.9 1.0 1.1e-10 41.3 0.0 2.8 2 1 0 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 ESA03762.1 - 1.5e-08 34.8 0.1 3.6e-06 27.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.10 ESA03762.1 - 3.2e-07 29.4 0.2 0.011 14.5 0.0 2.3 1 1 1 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 ESA03762.1 - 5e-06 26.1 0.0 1.3e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 ESA03762.1 - 8e-06 25.6 0.0 2.3e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA03762.1 - 2.8e-05 24.1 0.1 0.0002 21.3 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 ESA03762.1 - 9.3e-05 21.5 0.0 0.00037 19.6 0.0 2.0 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESA03762.1 - 0.00011 21.7 0.3 0.026 13.9 0.0 2.9 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.8 ESA03762.1 - 0.00014 20.8 0.0 0.00024 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DNA_pol3_delta PF06144.8 ESA03762.1 - 0.00017 21.1 0.0 0.00033 20.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 ESA03762.1 - 0.0002 21.2 0.0 0.00053 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESA03762.1 - 0.00027 20.6 1.2 0.0039 16.8 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA03762.1 - 0.00043 20.0 0.1 0.0016 18.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESA03762.1 - 0.00052 20.3 0.2 0.014 15.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.16 ESA03762.1 - 0.0018 17.4 0.0 0.034 13.2 0.1 2.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 ESA03762.1 - 0.0022 18.8 0.1 0.0068 17.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESA03762.1 - 0.0051 16.7 0.1 0.063 13.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESA03762.1 - 0.0061 16.1 0.0 0.023 14.2 0.0 1.8 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESA03762.1 - 0.011 14.4 0.0 0.89 8.1 0.0 2.2 2 0 0 2 2 2 0 TIP49 C-terminus AAA_33 PF13671.1 ESA03762.1 - 0.013 15.4 0.0 0.062 13.1 0.0 2.2 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 ESA03762.1 - 0.013 14.7 0.0 2.5 7.2 0.0 3.1 3 0 0 3 3 3 0 PhoH-like protein FtsK_SpoIIIE PF01580.13 ESA03762.1 - 0.014 14.8 0.0 0.044 13.2 0.0 1.8 1 1 1 2 2 2 0 FtsK/SpoIIIE family ResIII PF04851.10 ESA03762.1 - 0.016 15.0 0.2 0.18 11.6 0.0 2.5 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_10 PF12846.2 ESA03762.1 - 0.021 14.2 0.6 0.59 9.5 0.0 2.6 2 1 1 3 3 3 0 AAA-like domain DUF2075 PF09848.4 ESA03762.1 - 0.024 13.6 0.0 0.065 12.2 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.24 ESA03762.1 - 0.026 13.9 0.1 0.3 10.5 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_23 PF13476.1 ESA03762.1 - 0.044 14.1 1.6 0.085 13.1 1.1 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA03762.1 - 0.053 13.6 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 ESA03762.1 - 0.054 12.8 0.0 0.42 10.0 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_2 PF07724.9 ESA03762.1 - 0.064 13.1 0.0 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Helitron_like_N PF14214.1 ESA03763.1 - 4.2e-08 33.1 0.2 6.7e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus TLD PF07534.11 ESA03765.1 - 1.1e-14 54.5 1.8 1.5e-14 54.2 1.2 1.1 1 0 0 1 1 1 1 TLD CENP-F_leu_zip PF10473.4 ESA03769.1 - 0.00075 19.3 1.5 0.00093 19.0 1.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.1 ESA03769.1 - 0.022 15.2 0.9 0.027 14.9 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) Microtub_assoc PF07989.6 ESA03769.1 - 0.034 13.9 0.4 0.052 13.3 0.3 1.4 1 0 0 1 1 1 0 Microtubule associated DUF4200 PF13863.1 ESA03769.1 - 0.036 13.9 1.1 0.048 13.6 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Seryl_tRNA_N PF02403.17 ESA03769.1 - 0.054 13.5 0.5 0.061 13.3 0.3 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TBPIP PF07106.8 ESA03769.1 - 0.06 12.8 0.6 0.064 12.7 0.4 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Mnd1 PF03962.10 ESA03769.1 - 0.08 12.5 0.6 0.093 12.3 0.4 1.0 1 0 0 1 1 1 0 Mnd1 family TMF_DNA_bd PF12329.3 ESA03769.1 - 0.14 11.9 3.2 0.22 11.3 1.8 1.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF148 PF02520.12 ESA03769.1 - 0.15 11.8 0.9 0.18 11.5 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF972 PF06156.8 ESA03769.1 - 0.41 11.0 2.9 0.69 10.2 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF2457 PF10446.4 ESA03770.1 - 0.17 10.5 4.6 0.21 10.2 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3295 PF11702.3 ESA03770.1 - 0.44 9.4 2.2 0.51 9.2 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DivIC PF04977.10 ESA03771.1 - 0.12 11.9 0.1 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Septum formation initiator ATP-synt_C PF00137.16 ESA03773.1 - 9e-23 79.9 23.6 2.8e-13 49.5 7.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2592 PF10766.4 ESA03773.1 - 0.22 10.8 5.7 0.54 9.6 4.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2592) Glycophorin_A PF01102.13 ESA03773.1 - 0.26 11.0 1.3 0.4 10.4 0.9 1.2 1 0 0 1 1 1 0 Glycophorin A WD40 PF00400.27 ESA03774.1 - 2.1e-42 141.5 28.6 3e-07 30.0 0.0 11.9 12 0 0 12 12 12 8 WD domain, G-beta repeat Nup160 PF11715.3 ESA03774.1 - 7.3e-05 21.0 2.5 0.0022 16.1 0.0 2.9 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.9 ESA03774.1 - 0.00099 18.0 0.1 0.15 10.8 0.0 3.1 4 0 0 4 4 4 2 Coatomer WD associated region LST1 PF05083.8 ESA03774.1 - 0.051 13.5 0.1 0.2 11.6 0.1 2.0 2 0 0 2 2 2 0 LST-1 protein CutA1 PF03091.10 ESA03775.1 - 3.6e-39 132.5 1.3 4.1e-39 132.3 0.9 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Suppressor_APC PF11414.3 ESA03775.1 - 0.0098 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein DnaJ PF00226.26 ESA03776.1 - 1.3e-23 82.5 1.1 1.4e-23 82.4 0.7 1.0 1 0 0 1 1 1 1 DnaJ domain DUF872 PF05915.7 ESA03777.1 - 5.1e-23 81.1 0.1 5.5e-23 81.0 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) YrhK PF14145.1 ESA03777.1 - 0.021 14.5 4.3 0.48 10.1 0.2 2.2 2 0 0 2 2 2 0 YrhK-like protein PEMT PF04191.8 ESA03779.1 - 1.2e-12 47.8 0.6 1.4e-12 47.6 0.4 1.1 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.9 ESA03779.1 - 7.3e-11 42.1 0.3 9.3e-11 41.7 0.2 1.1 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.7 ESA03779.1 - 5e-07 29.2 0.2 5.5e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.11 ESA03779.1 - 0.00017 21.3 0.3 0.0002 21.1 0.2 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ERG4_ERG24 PF01222.12 ESA03779.1 - 0.00025 19.7 1.0 0.00027 19.5 0.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF2178 PF09946.4 ESA03779.1 - 0.0041 16.8 0.3 0.0064 16.2 0.2 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2178) Pkinase PF00069.20 ESA03781.1 - 2.1e-44 151.6 0.1 2.9e-44 151.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03781.1 - 2.5e-42 144.7 0.0 3.3e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA03781.1 - 0.0014 18.4 0.1 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA03781.1 - 0.0093 15.3 0.9 0.035 13.4 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA03781.1 - 0.03 13.3 0.0 0.055 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BEN PF10523.4 ESA03783.1 - 0.0069 16.4 0.3 0.028 14.4 0.1 2.0 1 1 1 2 2 2 1 BEN domain SopE_GEF PF07487.8 ESA03783.1 - 0.011 15.6 0.1 0.019 14.9 0.1 1.6 1 1 0 1 1 1 0 SopE GEF domain TFCD_C PF12612.3 ESA03784.1 - 0.1 11.9 0.1 0.23 10.8 0.1 1.5 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal DUF3829 PF12889.2 ESA03785.1 - 0.022 13.9 0.9 0.026 13.7 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DUF4375 PF14300.1 ESA03785.1 - 0.044 13.7 0.6 0.058 13.3 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) DUF2458 PF10454.4 ESA03785.1 - 0.053 13.4 4.0 0.076 12.8 2.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) Adap_comp_sub PF00928.16 ESA03787.1 - 1e-64 218.1 0.2 2.2e-64 217.1 0.0 1.6 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESA03787.1 - 2.3e-06 27.3 2.3 3e-06 26.9 1.1 1.6 1 1 1 2 2 2 1 Clathrin adaptor complex small chain Sec15 PF04091.7 ESA03788.1 - 7.1e-107 357.3 3.6 1.3e-106 356.4 2.5 1.4 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like CCDC92 PF14916.1 ESA03789.1 - 0.00049 19.6 0.7 0.022 14.3 0.4 2.3 2 0 0 2 2 2 1 Coiled-coil domain of unknown function Microtub_assoc PF07989.6 ESA03789.1 - 0.0061 16.3 6.3 0.39 10.5 0.9 2.7 1 1 2 3 3 3 2 Microtubule associated DivIC PF04977.10 ESA03789.1 - 0.0074 15.7 10.5 0.097 12.1 0.7 2.6 1 1 1 2 2 2 2 Septum formation initiator TMF_DNA_bd PF12329.3 ESA03789.1 - 0.008 15.9 11.5 0.1 12.3 4.0 2.4 1 1 2 3 3 3 3 TATA element modulatory factor 1 DNA binding DUF972 PF06156.8 ESA03789.1 - 0.011 16.1 7.2 0.31 11.3 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Pox_I3 PF04661.7 ESA03789.1 - 0.011 14.5 0.4 0.012 14.3 0.3 1.2 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein ATG16 PF08614.6 ESA03789.1 - 0.019 14.7 3.9 0.029 14.2 2.7 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) APG6 PF04111.7 ESA03789.1 - 0.026 13.5 1.8 0.029 13.4 1.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 NYD-SP28_assoc PF14775.1 ESA03789.1 - 0.029 14.0 1.9 0.029 14.0 1.3 2.5 2 2 1 3 3 3 0 Sperm tail C-terminal domain Plant_NMP1 PF06694.6 ESA03789.1 - 0.053 12.4 0.3 0.058 12.3 0.2 1.0 1 0 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) DUF1843 PF08898.5 ESA03789.1 - 0.093 12.7 3.7 6.7 6.8 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1843) HALZ PF02183.13 ESA03789.1 - 0.12 12.1 8.9 0.57 9.9 3.2 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF904 PF06005.7 ESA03789.1 - 0.13 12.5 11.6 1.4 9.2 2.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF1640 PF07798.6 ESA03789.1 - 0.15 12.0 3.7 0.31 11.0 0.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF724 PF05266.9 ESA03789.1 - 0.17 11.4 5.3 0.49 9.9 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.6 ESA03789.1 - 0.2 11.5 4.9 9.4 6.2 0.1 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Nup54 PF13874.1 ESA03789.1 - 0.22 11.1 3.6 1.3 8.7 0.6 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF2680 PF10925.3 ESA03789.1 - 0.23 11.3 1.0 1.9 8.3 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2680) Shugoshin_N PF07558.6 ESA03789.1 - 0.31 10.7 8.3 0.12 12.0 1.0 3.3 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region TBPIP PF07106.8 ESA03789.1 - 0.56 9.7 7.4 0.45 10.0 0.7 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) bZIP_2 PF07716.10 ESA03789.1 - 0.6 9.9 7.8 5.2 6.9 1.5 3.3 2 2 0 3 3 3 0 Basic region leucine zipper bZIP_1 PF00170.16 ESA03789.1 - 0.67 9.9 9.7 3.8 7.5 1.6 3.0 1 1 2 3 3 3 0 bZIP transcription factor Herpes_BLRF2 PF05812.7 ESA03789.1 - 0.87 9.4 5.7 3.9 7.3 4.0 2.0 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein Mto2_bdg PF12808.2 ESA03789.1 - 1.1 9.4 8.9 2.2 8.4 2.2 2.7 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TSC22 PF01166.13 ESA03789.1 - 6.8 6.7 9.0 14 5.6 2.1 2.7 1 1 1 2 2 2 0 TSC-22/dip/bun family BID PF06393.6 ESA03791.1 - 0.053 12.8 0.5 0.11 11.8 0.1 1.6 2 0 0 2 2 2 0 BH3 interacting domain (BID) Proteasome_A_N PF10584.4 ESA03792.1 - 0.026 13.8 0.2 5 6.5 0.0 2.7 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Ifi-6-16 PF06140.8 ESA03793.1 - 1.2e-11 44.2 22.7 1.9e-11 43.6 15.3 1.6 1 1 0 1 1 1 1 Interferon-induced 6-16 family DUF3392 PF11872.3 ESA03793.1 - 0.12 12.3 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3392) DUF287 PF03384.9 ESA03794.1 - 0.02 15.0 1.5 0.089 12.9 0.2 2.4 2 0 0 2 2 2 0 Drosophila protein of unknown function, DUF287 Pkinase_Tyr PF07714.12 ESA03795.1 - 1.9e-39 135.2 0.0 2.2e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03795.1 - 8.5e-38 129.9 0.1 1e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA03795.1 - 0.0018 17.5 0.3 0.003 16.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA03796.1 - 1.2e-39 135.9 0.0 1.5e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03796.1 - 3.3e-38 131.3 0.0 3.8e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA03796.1 - 0.00021 21.0 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA03796.1 - 0.0024 17.2 0.1 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA03796.1 - 0.0059 15.8 0.1 0.0093 15.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA03796.1 - 0.061 12.3 0.1 0.09 11.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF806 PF05657.6 ESA03796.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF806) BTB PF00651.26 ESA03798.1 - 3.9e-16 59.0 0.1 5.1e-16 58.6 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Baculo_LEF-11 PF06385.7 ESA03798.1 - 0.11 12.5 0.3 0.28 11.2 0.1 1.8 2 0 0 2 2 2 0 Baculovirus LEF-11 protein Corona_nucleoca PF00937.13 ESA03800.1 - 0.32 9.9 16.9 0.35 9.7 11.7 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Transformer PF06495.6 ESA03800.1 - 4.2 7.2 17.6 5.2 6.8 12.2 1.1 1 0 0 1 1 1 0 Fruit fly transformer protein BTB PF00651.26 ESA03801.1 - 2e-18 66.3 0.1 5.7e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA03801.1 - 2e-05 24.3 5.5 3.4e-05 23.6 0.7 3.3 3 1 0 3 3 3 1 BTB And C-terminal Kelch Xpo1 PF08389.7 ESA03801.1 - 0.021 14.7 0.9 0.29 11.0 0.2 3.0 3 1 0 3 3 3 0 Exportin 1-like protein TLD PF07534.11 ESA03801.1 - 0.035 14.1 5.8 1.8 8.5 2.8 2.7 2 1 0 2 2 2 0 TLD BTB PF00651.26 ESA03802.1 - 9.5e-17 60.9 0.1 1.1e-15 57.5 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA03802.1 - 1.6e-09 37.5 3.2 5.1e-08 32.6 0.1 3.4 3 1 1 4 4 4 1 BTB And C-terminal Kelch PolyA_pol PF01743.15 ESA03802.1 - 0.0039 17.3 0.1 0.022 14.9 0.0 2.1 2 0 0 2 2 2 1 Poly A polymerase head domain BTB PF00651.26 ESA03804.1 - 2.4e-16 59.7 0.3 7.8e-16 58.0 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA03804.1 - 2.3e-08 33.7 0.4 5.5e-06 26.1 0.1 3.2 3 1 1 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA03804.1 - 0.0052 15.9 0.6 0.0073 15.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) DUF3447 PF11929.3 ESA03805.1 - 0.31 10.8 2.2 0.49 10.2 1.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3447) SNF2_N PF00176.18 ESA03810.1 - 6.1e-46 156.5 0.0 1.5e-45 155.2 0.0 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain SAM_2 PF07647.12 ESA03810.1 - 1.4e-11 44.0 0.3 4.1e-11 42.5 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Helicase_C PF00271.26 ESA03810.1 - 2e-11 43.6 0.0 5.6e-11 42.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SAM_1 PF00536.25 ESA03810.1 - 6.9e-06 26.1 0.3 3.3e-05 23.9 0.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) CPL PF08144.6 ESA03811.1 - 1.6e-24 86.4 0.1 6.8e-24 84.3 0.0 2.2 1 0 0 1 1 1 1 CPL (NUC119) domain PUF PF00806.14 ESA03811.1 - 0.39 10.2 2.8 2.4 7.8 0.1 3.7 5 0 0 5 5 5 0 Pumilio-family RNA binding repeat Reprolysin_5 PF13688.1 ESA03812.1 - 5.1e-42 144.0 1.0 5.1e-42 144.0 0.7 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.1 ESA03812.1 - 1.1e-39 136.0 0.1 2.5e-39 134.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 ESA03812.1 - 3.2e-37 128.2 2.0 4.5e-37 127.7 0.1 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.18 ESA03812.1 - 3.6e-19 68.7 31.8 3.6e-19 68.7 22.0 4.7 3 1 1 4 4 4 1 Disintegrin Reprolysin_3 PF13582.1 ESA03812.1 - 6.8e-19 68.6 0.0 6.8e-19 68.6 0.0 2.6 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.14 ESA03812.1 - 1.6e-07 31.2 0.0 1.1e-06 28.4 0.0 2.3 2 0 0 2 2 2 1 Reprolysin family propeptide GP41 PF00517.12 ESA03812.1 - 0.26 10.8 0.0 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 Retroviral envelope protein Pex14_N PF04695.8 ESA03813.1 - 0.0073 16.3 1.6 0.009 16.0 1.1 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4175 PF13779.1 ESA03813.1 - 0.035 11.8 4.4 0.042 11.5 3.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RR_TM4-6 PF06459.7 ESA03813.1 - 0.038 13.8 9.8 0.044 13.6 6.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.5 ESA03813.1 - 0.45 10.5 12.8 0.51 10.3 8.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Raftlin PF15250.1 ESA03813.1 - 0.61 8.5 6.2 0.66 8.4 4.3 1.0 1 0 0 1 1 1 0 Raftlin DUF3807 PF12720.2 ESA03813.1 - 0.64 10.1 14.2 0.74 9.9 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) FAM60A PF15396.1 ESA03813.1 - 0.77 9.4 4.2 0.88 9.2 2.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A MIP-T3 PF10243.4 ESA03813.1 - 0.88 7.9 16.6 0.98 7.8 11.5 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF913 PF06025.7 ESA03813.1 - 1.5 7.5 4.2 1.6 7.3 2.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Adaptin_binding PF10199.4 ESA03813.1 - 2.1 8.6 14.4 2.7 8.2 10.0 1.1 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF3530 PF12048.3 ESA03813.1 - 3.3 6.6 8.2 3.7 6.4 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) HSP90 PF00183.13 ESA03813.1 - 3.6 5.8 12.3 3.9 5.7 8.5 1.1 1 0 0 1 1 1 0 Hsp90 protein Hid1 PF12722.2 ESA03813.1 - 3.7 5.1 11.1 3.9 5.0 7.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dicty_REP PF05086.7 ESA03813.1 - 3.8 5.1 9.6 4.1 5.0 6.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RP-C_C PF11800.3 ESA03813.1 - 4 7.0 6.5 4.4 6.9 4.5 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Herpes_LMP1 PF05297.6 ESA03813.1 - 5.7 5.7 7.6 6.6 5.5 5.3 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Spore_coat_CotO PF14153.1 ESA03813.1 - 6.3 6.1 12.6 7 6.0 8.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO CDC45 PF02724.9 ESA03813.1 - 6.5 4.6 12.9 6.8 4.5 8.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2201_N PF13203.1 ESA03813.1 - 6.7 5.7 8.1 7.4 5.6 5.6 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Presenilin PF01080.12 ESA03813.1 - 7.5 5.2 9.4 7.9 5.1 6.5 1.0 1 0 0 1 1 1 0 Presenilin Lzipper-MIP1 PF14389.1 ESA03814.1 - 0.0042 17.1 11.6 0.0042 17.1 8.1 3.6 2 2 1 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 ADIP PF11559.3 ESA03814.1 - 0.0087 15.9 5.1 0.0087 15.9 3.5 4.3 2 2 2 4 4 4 2 Afadin- and alpha -actinin-Binding KH_5 PF13184.1 ESA03814.1 - 0.032 14.0 0.2 0.11 12.2 0.2 1.9 1 0 0 1 1 1 0 NusA-like KH domain Tet_JBP PF12851.2 ESA03814.1 - 0.051 12.8 4.3 0.11 11.7 0.3 2.4 2 0 0 2 2 2 0 Oxygenase domain of the 2OGFeDO superfamily DUF1479 PF07350.7 ESA03814.1 - 4.8 5.5 15.1 0.54 8.6 3.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1479) Reo_sigmaC PF04582.7 ESA03814.1 - 5.8 5.9 14.6 0.37 9.9 3.6 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein GrpB PF04229.9 ESA03815.1 - 0.014 15.0 4.3 0.023 14.4 0.1 2.9 3 0 0 3 3 3 0 GrpB protein Sox_N PF12444.3 ESA03815.1 - 0.75 10.9 5.3 3 9.0 0.1 3.0 2 2 0 2 2 2 0 Sox developmental protein N terminal DZR PF12773.2 ESA03816.1 - 2.9 7.7 8.2 0.5 10.2 2.5 2.0 2 0 0 2 2 2 0 Double zinc ribbon HTH_Tnp_Tc5 PF03221.11 ESA03817.1 - 0.1 12.4 0.6 0.16 11.7 0.4 1.3 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF2716 PF10898.3 ESA03818.1 - 2.6 8.0 7.9 0.71 9.8 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2716) DUF605 PF04652.11 ESA03818.1 - 8.2 5.7 23.0 12 5.1 15.9 1.3 1 1 0 1 1 1 0 Vta1 like Myb_DNA-bind_6 PF13921.1 ESA03819.1 - 0.00095 19.2 2.1 0.0022 18.0 0.0 2.6 2 1 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA03819.1 - 0.0051 16.8 1.0 1.2 9.2 0.0 3.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain Sulfotransfer_1 PF00685.22 ESA03819.1 - 0.019 14.2 0.4 4.8 6.3 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase domain Kelch_4 PF13418.1 ESA03820.1 - 3.2e-20 71.6 7.5 0.0046 16.6 0.5 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA03820.1 - 7.3e-19 67.4 7.5 0.00011 22.2 0.0 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA03820.1 - 3.5e-15 55.5 5.7 0.016 15.1 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESA03820.1 - 9e-15 54.1 18.1 0.0031 17.6 0.0 6.4 6 1 1 7 7 7 4 Kelch motif Kelch_1 PF01344.20 ESA03820.1 - 1.7e-07 30.6 2.4 0.81 9.2 0.0 5.0 5 0 0 5 5 5 3 Kelch motif TctA PF01970.11 ESA03820.1 - 0.12 10.7 0.0 0.18 10.1 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family Podoplanin PF05808.6 ESA03820.1 - 0.14 11.7 0.2 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 Podoplanin Kelch_2 PF07646.10 ESA03820.1 - 0.19 11.5 9.4 2.2 8.2 0.0 4.7 6 2 0 6 6 6 0 Kelch motif Cdc6_C PF09079.6 ESA03821.1 - 0.04 13.6 0.3 0.061 13.0 0.2 1.4 1 1 0 1 1 1 0 CDC6, C terminal LptE PF04390.7 ESA03822.1 - 0.25 11.0 1.2 0.4 10.4 0.8 1.4 1 0 0 1 1 1 0 Lipopolysaccharide-assembly MreB_Mbl PF06723.8 ESA03823.1 - 0.00059 18.5 0.0 0.046 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein MreB_Mbl PF06723.8 ESA03825.1 - 2.6e-08 32.8 0.0 0.0041 15.7 0.0 2.1 1 1 1 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA03825.1 - 6e-06 24.4 0.1 0.00059 17.8 0.1 2.6 2 1 0 2 2 2 2 Hsp70 protein BcrAD_BadFG PF01869.15 ESA03825.1 - 0.068 12.4 0.0 0.14 11.4 0.0 1.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family MreB_Mbl PF06723.8 ESA03826.1 - 0.0035 15.9 0.0 0.19 10.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Toxin_trans PF07952.7 ESA03833.1 - 0.039 12.8 0.4 0.05 12.5 0.3 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain Svf1 PF08622.5 ESA03833.1 - 0.054 12.4 0.1 0.075 12.0 0.1 1.2 1 0 0 1 1 1 0 Svf1-like RNase_H PF00075.19 ESA03834.1 - 1e-09 38.8 0.0 1.4e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 RNase H BTB PF00651.26 ESA03836.1 - 1.5e-10 41.0 0.4 2.2e-10 40.5 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain F-box PF00646.28 ESA03836.1 - 0.13 11.9 0.4 0.28 10.9 0.3 1.6 1 0 0 1 1 1 0 F-box domain Uma2 PF05685.7 ESA03838.1 - 1.2e-05 24.7 0.0 1.5e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-RING_5 PF14634.1 ESA03840.1 - 0.0027 17.3 7.8 0.0059 16.3 5.4 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA03840.1 - 0.0034 17.0 1.2 0.0034 17.0 0.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA03840.1 - 0.0047 17.0 2.1 0.0099 15.9 1.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA03840.1 - 0.0082 16.1 2.1 0.0082 16.1 1.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Peptidase_S64 PF08192.6 ESA03840.1 - 0.014 13.8 1.6 0.016 13.5 1.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4662 PF15578.1 ESA03840.1 - 0.043 13.4 0.7 0.057 12.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) zf-RING_2 PF13639.1 ESA03840.1 - 0.054 13.3 8.7 0.21 11.4 6.0 2.0 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.20 ESA03840.1 - 3.3 7.4 8.9 17 5.1 6.2 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pox_A32 PF04665.7 ESA03845.1 - 6.9e-08 32.0 0.1 8.1e-08 31.8 0.0 1.0 1 0 0 1 1 1 1 Poxvirus A32 protein Zot PF05707.7 ESA03845.1 - 0.017 14.5 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) Kelch_3 PF13415.1 ESA03847.1 - 2.3e-07 30.7 0.2 0.034 14.3 0.0 3.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA03847.1 - 0.003 17.6 10.9 0.78 10.0 0.0 5.2 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESA03847.1 - 0.039 13.5 0.5 0.039 13.5 0.3 4.3 6 0 0 6 6 6 0 Kelch motif Kelch_5 PF13854.1 ESA03847.1 - 0.076 12.9 7.1 0.39 10.7 0.0 3.9 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.10 ESA03847.1 - 0.49 10.2 5.7 18 5.2 0.0 4.8 6 0 0 6 6 6 0 Kelch motif Kelch_4 PF13418.1 ESA03847.1 - 2.3 8.0 6.5 0.93 9.3 0.1 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain MPC PF03650.8 ESA03848.1 - 3.9e-31 107.4 0.0 6.5e-31 106.7 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0041) DUF4441 PF14536.1 ESA03849.1 - 0.14 12.0 3.1 7.1 6.6 0.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) ubiquitin PF00240.18 ESA03850.1 - 0.12 11.7 0.2 0.21 11.0 0.2 1.5 1 1 0 1 1 1 0 Ubiquitin family Pkinase PF00069.20 ESA03853.1 - 0.01 15.0 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03853.1 - 0.042 12.9 0.0 0.052 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase AIG1 PF04548.11 ESA03855.1 - 1.6e-10 40.4 1.0 2.5e-10 39.8 0.7 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA03855.1 - 2.4e-07 30.7 0.3 4.5e-07 29.8 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA03855.1 - 0.00069 20.4 1.8 0.001 19.8 0.5 1.9 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.1 ESA03855.1 - 0.00083 19.6 0.9 0.0021 18.3 0.6 2.0 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.12 ESA03855.1 - 0.0017 18.2 0.2 0.016 15.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 T2SE PF00437.15 ESA03855.1 - 0.0028 16.6 0.1 0.0055 15.6 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 ESA03855.1 - 0.004 16.6 0.1 0.0086 15.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MobB PF03205.9 ESA03855.1 - 0.0051 16.5 0.7 0.0091 15.7 0.5 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B G-alpha PF00503.15 ESA03855.1 - 0.0058 15.3 1.2 0.074 11.7 0.3 2.1 1 1 1 2 2 2 1 G-protein alpha subunit ABC_tran PF00005.22 ESA03855.1 - 0.0075 16.5 2.3 0.025 14.8 1.6 2.0 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 ESA03855.1 - 0.0096 15.1 0.3 0.018 14.2 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESA03855.1 - 0.01 15.9 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESA03855.1 - 0.03 14.2 0.3 0.054 13.4 0.2 1.4 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 ESA03855.1 - 0.032 13.5 0.2 0.06 12.6 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.13 ESA03855.1 - 0.042 13.3 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family GTP_EFTU PF00009.22 ESA03855.1 - 0.056 12.8 0.2 0.22 10.9 0.2 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Sigma54_activat PF00158.21 ESA03855.1 - 0.086 12.3 0.1 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 ESA03855.1 - 0.086 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.1 ESA03855.1 - 0.13 12.1 0.2 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF2057 PF09829.4 ESA03855.1 - 0.15 11.7 0.2 4.3 6.9 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Methyltransf_11 PF08241.7 ESA03856.1 - 2.2e-13 50.4 0.0 3.8e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA03856.1 - 1.1e-10 41.3 0.0 4.9e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA03856.1 - 3.5e-10 40.1 0.0 7.2e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA03856.1 - 2.3e-09 37.1 0.0 3.1e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA03856.1 - 1.2e-07 31.3 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA03856.1 - 5.1e-06 27.0 0.0 6.1e-05 23.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA03856.1 - 3e-05 23.2 0.0 6.5e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_26 PF13659.1 ESA03856.1 - 0.00025 21.0 0.0 0.00055 19.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA03856.1 - 0.00062 20.1 0.1 0.0033 17.8 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA03856.1 - 0.00086 18.4 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 ESA03856.1 - 0.0012 18.0 0.0 0.0051 15.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 ESA03856.1 - 0.0024 17.9 0.0 0.0031 17.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ESA03856.1 - 0.012 14.8 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase CMAS PF02353.15 ESA03856.1 - 0.027 13.5 0.0 0.067 12.2 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase BTB PF00651.26 ESA03857.1 - 2.2e-08 34.0 0.9 4.3e-08 33.1 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA03857.1 - 6.6e-07 29.4 2.5 6.6e-07 29.4 1.7 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA03857.1 - 3.1e-06 26.9 3.3 1.7e-05 24.6 0.3 3.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch GMC_oxred_C PF05199.8 ESA03858.1 - 1.8e-36 125.5 0.0 2.2e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase zf-C2H2 PF00096.21 ESA03859.1 - 0.0017 18.5 1.0 0.0017 18.5 0.7 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type DDE_Tnp_ISAZ013 PF07592.6 ESA03859.1 - 0.0092 14.7 0.1 0.17 10.6 0.0 2.2 2 0 0 2 2 2 1 Rhodopirellula transposase DDE domain DUF2951 PF11166.3 ESA03860.1 - 3.4 7.5 6.2 4.6 7.1 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) MUG2_C PF08593.5 ESA03861.1 - 0.059 13.6 0.4 0.077 13.2 0.2 1.2 1 0 0 1 1 1 0 Meiotically up-regulated glycoproteins C-terminal MitMem_reg PF13012.1 ESA03862.1 - 1.1e-21 77.0 0.0 2.1e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 ESA03862.1 - 5.1e-20 71.3 0.2 9.2e-20 70.4 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.8 ESA03862.1 - 0.0051 16.3 0.0 0.0087 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) WD40 PF00400.27 ESA03863.1 - 3e-24 83.9 15.5 6.9e-10 38.4 0.1 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 ESA03863.1 - 3.8e-20 71.5 0.0 1.1e-19 70.0 0.0 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ABC_tran PF00005.22 ESA03864.1 - 3.6e-15 56.4 0.8 2.3e-14 53.8 0.1 2.4 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 ESA03864.1 - 3.8e-11 43.4 2.3 2.7e-05 24.2 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.1 ESA03864.1 - 2.8e-08 33.2 0.0 0.0033 16.5 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 ESA03864.1 - 4.8e-05 22.8 0.0 0.0001 21.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.14 ESA03864.1 - 0.00014 21.1 0.1 0.15 11.2 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 ESA03864.1 - 0.00042 19.7 0.0 0.00086 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 ESA03864.1 - 0.00066 20.0 2.0 0.022 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA03864.1 - 0.00089 18.4 0.1 0.0018 17.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Arf PF00025.16 ESA03864.1 - 0.0018 17.5 0.1 0.005 16.1 0.1 1.8 1 0 0 1 1 1 1 ADP-ribosylation factor family FtsK_SpoIIIE PF01580.13 ESA03864.1 - 0.0028 17.1 0.0 0.006 16.0 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family SRP54 PF00448.17 ESA03864.1 - 0.0087 15.5 0.2 0.015 14.7 0.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 ESA03864.1 - 0.0099 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Septin PF00735.13 ESA03864.1 - 0.014 14.4 0.2 5.4 5.9 0.0 2.7 3 0 0 3 3 3 0 Septin Miro PF08477.8 ESA03864.1 - 0.046 14.2 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 ESA03864.1 - 0.061 13.3 1.1 0.21 11.5 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 ESA03864.1 - 0.07 13.9 1.0 0.26 12.1 0.7 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESA03864.1 - 0.088 12.7 0.6 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain MutS_V PF00488.16 ESA03864.1 - 0.11 11.8 0.1 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 MutS domain V PQ-loop PF04193.9 ESA03865.1 - 7.6e-23 79.8 22.3 5e-13 48.3 2.1 3.7 2 1 1 3 3 3 2 PQ loop repeat CcmH PF03918.9 ESA03865.1 - 1.6 7.7 4.4 2.4 7.1 0.1 2.4 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Syndecan PF01034.15 ESA03865.1 - 3.3 7.4 5.0 17 5.1 0.2 3.2 3 0 0 3 3 3 0 Syndecan domain WD40 PF00400.27 ESA03866.1 - 7.4e-65 212.6 25.9 3.4e-12 45.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA03866.1 - 5.6e-06 24.7 9.7 0.016 13.4 0.2 4.7 2 2 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.7 ESA03866.1 - 0.0095 15.5 1.1 4.7 6.9 0.0 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 ESA03866.1 - 0.063 11.5 0.0 1 7.5 0.0 2.4 2 0 0 2 2 2 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.6 ESA03866.1 - 0.09 11.5 1.5 20 3.7 0.0 3.3 2 1 1 3 3 3 0 Nup133 N terminal like HTH_Tnp_Tc3_1 PF11427.3 ESA03867.1 - 0.081 12.5 0.4 0.12 12.0 0.3 1.2 1 0 0 1 1 1 0 Tc3 transposase Diacid_rec PF05651.8 ESA03867.1 - 0.14 11.6 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative sugar diacid recognition HD_4 PF13328.1 ESA03869.1 - 2.4e-21 76.0 0.2 3.1e-21 75.6 0.1 1.2 1 0 0 1 1 1 1 HD domain HD PF01966.17 ESA03869.1 - 0.053 13.5 0.2 0.45 10.5 0.1 2.1 1 1 1 2 2 2 0 HD domain COX16 PF14138.1 ESA03869.1 - 0.29 11.3 1.6 0.56 10.4 1.1 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 IF-2B PF01008.12 ESA03870.1 - 1e-71 241.2 0.8 1.9e-71 240.3 0.6 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family E2_bind PF08825.5 ESA03870.1 - 0.065 13.0 0.1 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 E2 binding domain CR6_interact PF10147.4 ESA03871.1 - 0.00044 19.6 3.0 0.0005 19.4 2.1 1.2 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Sel1 PF08238.7 ESA03873.1 - 8.1e-86 280.5 43.5 6.5e-13 48.8 0.5 8.0 8 0 0 8 8 8 8 Sel1 repeat TPR_17 PF13431.1 ESA03873.1 - 2.4e-06 27.3 19.5 2.1 8.7 0.1 8.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA03873.1 - 3.1e-06 27.2 17.6 2 9.0 0.0 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat MIT PF04212.13 ESA03873.1 - 5.1e-05 23.0 25.7 2.1 8.3 0.1 6.3 6 1 0 6 6 6 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA03873.1 - 0.13 11.9 11.4 29 4.4 0.0 5.3 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation ApbA PF02558.11 ESA03873.1 - 0.15 11.5 2.1 17 4.8 0.0 4.4 2 2 2 5 5 5 0 Ketopantoate reductase PanE/ApbA 23S_rRNA_IVP PF05635.6 ESA03873.1 - 0.15 11.9 4.0 0.44 10.4 0.1 2.7 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein AnfG_VnfG PF03139.10 ESA03873.1 - 1.6 8.5 4.7 11 5.9 0.0 3.6 3 2 2 5 5 5 0 Vanadium/alternative nitrogenase delta subunit STE PF02200.11 ESA03873.1 - 1.8 8.7 16.5 15 5.7 0.0 6.2 3 1 4 7 7 7 0 STE like transcription factor HTH_16 PF12645.2 ESA03873.1 - 1.9 8.4 5.1 16 5.4 0.1 3.9 5 0 0 5 5 5 0 Helix-turn-helix domain Toxin_51 PF15531.1 ESA03873.1 - 2.6 7.8 8.9 0.43 10.3 1.4 2.9 1 1 1 2 2 2 0 Putative toxin 51 DUF2207 PF09972.4 ESA03874.1 - 3.4 6.1 6.6 3.9 5.9 4.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-DHHC PF01529.15 ESA03874.1 - 4.5 6.6 6.3 5.9 6.2 4.4 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase Pkinase_Tyr PF07714.12 ESA03875.1 - 2.7e-33 115.1 0.0 5e-33 114.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03875.1 - 5.9e-30 104.2 0.0 9.9e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SR-25 PF10500.4 ESA03876.1 - 0.46 9.9 7.7 0.53 9.7 5.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 ESA03876.1 - 0.49 10.4 8.1 0.58 10.2 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Vps52 PF04129.7 ESA03877.1 - 0.13 10.7 1.3 0.15 10.5 0.9 1.0 1 0 0 1 1 1 0 Vps52 / Sac2 family 4HBT_2 PF13279.1 ESA03878.1 - 6e-12 46.0 0.0 8.2e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.12 ESA03878.1 - 2.8e-05 23.1 0.3 4.4e-05 22.5 0.2 1.2 1 0 0 1 1 1 1 Acyl-ACP thioesterase LtrA PF06772.6 ESA03879.1 - 1.1e-35 123.2 24.0 3.6e-22 78.7 9.5 2.9 3 0 0 3 3 3 2 Bacterial low temperature requirement A protein (LtrA) Auxin_repressed PF05564.7 ESA03879.1 - 0.097 13.2 2.5 0.15 12.6 0.8 2.0 2 0 0 2 2 2 0 Dormancy/auxin associated protein LtrA PF06772.6 ESA03880.1 - 2.2e-33 115.6 26.8 1.4e-20 73.5 10.9 2.7 3 0 0 3 3 3 2 Bacterial low temperature requirement A protein (LtrA) Pex14_N PF04695.8 ESA03880.1 - 0.24 11.4 1.1 0.87 9.6 0.5 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF904 PF06005.7 ESA03880.1 - 0.47 10.7 5.0 0.41 10.9 2.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Med21 PF11221.3 ESA03880.1 - 2.4 8.1 8.0 0.23 11.4 1.4 2.1 2 0 0 2 2 2 0 Subunit 21 of Mediator complex DUF2457 PF10446.4 ESA03883.1 - 0.67 8.6 7.9 0.94 8.1 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 ESA03883.1 - 0.76 9.2 3.7 1.6 8.2 2.5 1.4 1 0 0 1 1 1 0 Nucleoplasmin DUF4611 PF15387.1 ESA03883.1 - 2.6 8.2 6.3 1.1 9.4 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) RNA_POL_M_15KD PF02150.11 ESA03884.1 - 6.3e-10 38.5 1.6 9.4e-10 38.0 1.1 1.3 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit RecR PF02132.10 ESA03884.1 - 0.0031 16.9 1.9 0.22 11.0 1.8 2.2 1 1 1 2 2 2 1 RecR protein DZR PF12773.2 ESA03884.1 - 0.013 15.3 0.3 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon DUF2387 PF09526.5 ESA03884.1 - 0.017 15.0 0.7 0.021 14.7 0.5 1.1 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) DUF2082 PF09855.4 ESA03884.1 - 0.062 13.1 0.4 0.08 12.7 0.3 1.4 1 0 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-PHD-like PF15446.1 ESA03884.1 - 0.081 12.2 0.2 0.088 12.0 0.1 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Rubredoxin PF00301.15 ESA03884.1 - 0.19 11.6 1.1 1.7 8.5 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin NOB1_Zn_bind PF08772.6 ESA03884.1 - 0.25 11.2 3.6 3.4 7.5 0.3 2.2 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like RRM_1 PF00076.17 ESA03885.1 - 3.7e-58 193.0 0.0 3.2e-20 71.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03885.1 - 2.1e-42 142.9 0.0 1.4e-13 50.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03885.1 - 1.6e-20 72.7 0.0 5.3e-06 26.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA03885.1 - 0.00031 20.5 0.0 2.4 8.0 0.0 3.3 3 0 0 3 3 3 2 RNA binding motif FAD_binding_3 PF01494.14 ESA03886.1 - 2.3e-14 53.2 0.0 1.7e-09 37.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.5 ESA03886.1 - 0.00024 20.0 0.0 0.0031 16.3 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Phage_portal PF04860.7 ESA03886.1 - 0.071 11.7 0.1 0.098 11.3 0.1 1.1 1 0 0 1 1 1 0 Phage portal protein DUF1313 PF07011.6 ESA03887.1 - 0.072 12.7 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1313) Baculo_PEP_C PF04513.7 ESA03889.1 - 5.3e-06 26.3 12.0 5.9e-05 22.9 1.7 1.8 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.6 ESA03889.1 - 0.0005 20.1 0.6 0.00072 19.6 0.4 1.3 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) APG17 PF04108.7 ESA03889.1 - 0.00063 18.6 1.3 0.00072 18.4 0.9 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Prominin PF05478.6 ESA03889.1 - 0.0011 16.5 1.0 0.0015 16.1 0.7 1.2 1 0 0 1 1 1 1 Prominin Phage_Mu_Gam PF07352.7 ESA03889.1 - 0.0022 17.5 1.3 0.21 11.1 0.0 2.4 1 1 1 2 2 2 1 Bacteriophage Mu Gam like protein GCN5L1 PF06320.8 ESA03889.1 - 0.0024 17.7 1.1 0.006 16.4 0.7 1.9 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Mer2 PF09074.5 ESA03889.1 - 0.0059 16.5 3.4 0.24 11.3 2.7 2.0 1 1 0 1 1 1 1 Mer2 DUF148 PF02520.12 ESA03889.1 - 0.0059 16.3 3.0 0.008 15.9 1.6 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF148 SF-assemblin PF06705.6 ESA03889.1 - 0.0062 15.7 5.0 0.087 11.9 3.3 1.9 1 1 0 1 1 1 1 SF-assemblin/beta giardin Syntaxin PF00804.20 ESA03889.1 - 0.007 16.5 3.4 0.78 9.9 0.7 2.7 1 1 1 2 2 2 2 Syntaxin RE_MjaI PF09568.5 ESA03889.1 - 0.011 15.2 0.3 0.023 14.2 0.1 1.6 1 1 1 2 2 2 0 MjaI restriction endonuclease Filament PF00038.16 ESA03889.1 - 0.013 15.0 1.1 0.017 14.6 0.8 1.2 1 0 0 1 1 1 0 Intermediate filament protein Vip3A_N PF12495.3 ESA03889.1 - 0.013 15.1 2.2 0.017 14.7 1.2 1.5 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal DUF2884 PF11101.3 ESA03889.1 - 0.017 14.4 0.7 0.03 13.6 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) LXG PF04740.7 ESA03889.1 - 0.025 14.3 1.6 0.19 11.5 0.3 2.0 1 1 1 2 2 2 0 LXG domain of WXG superfamily Transcrip_act PF04949.8 ESA03889.1 - 0.034 13.7 0.3 0.26 10.9 0.2 1.9 1 1 0 1 1 1 0 Transcriptional activator Bacillus_HBL PF05791.6 ESA03889.1 - 0.042 13.2 2.5 0.07 12.4 1.8 1.5 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF2450 PF10475.4 ESA03889.1 - 0.043 12.7 0.7 0.47 9.3 0.1 2.4 1 1 2 3 3 3 0 Protein of unknown function N-terminal domain (DUF2450) DUF1664 PF07889.7 ESA03889.1 - 0.05 13.3 2.1 0.33 10.7 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-18_N PF10496.4 ESA03889.1 - 0.058 13.2 1.4 0.27 11.1 0.9 2.2 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Apolipoprotein PF01442.13 ESA03889.1 - 0.059 12.8 0.0 0.098 12.1 0.0 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1640 PF07798.6 ESA03889.1 - 0.059 13.4 0.4 0.075 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Tektin PF03148.9 ESA03889.1 - 0.064 11.8 1.0 0.29 9.6 0.2 1.8 1 1 1 2 2 2 0 Tektin family Fib_alpha PF08702.5 ESA03889.1 - 0.12 12.5 2.4 0.15 12.1 1.7 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family COG2 PF06148.6 ESA03889.1 - 0.12 12.2 0.5 0.71 9.7 0.3 2.1 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 NPV_P10 PF05531.7 ESA03889.1 - 0.13 12.5 3.6 18 5.6 2.5 3.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Borrelia_lipo_2 PF06238.6 ESA03889.1 - 0.19 11.7 6.4 1.3 9.0 1.5 2.6 1 1 2 3 3 3 0 Borrelia burgdorferi BBR25 lipoprotein Seryl_tRNA_N PF02403.17 ESA03889.1 - 0.19 11.7 4.3 3.6 7.6 0.5 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF2935 PF11155.3 ESA03889.1 - 0.26 11.3 2.3 2.3 8.2 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Pkinase_Tyr PF07714.12 ESA03892.1 - 1.3e-16 60.4 0.0 1.9e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03892.1 - 2.5e-16 59.5 0.0 4.9e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF3131 PF11329.3 ESA03892.1 - 0.0076 14.9 0.1 0.011 14.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3131) DZR PF12773.2 ESA03892.1 - 0.14 11.9 2.8 0.27 11.0 1.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon Clathrin_H_link PF13838.1 ESA03893.1 - 0.017 15.0 0.1 0.038 13.8 0.1 1.6 1 0 0 1 1 1 0 Clathrin-H-link F-box-like PF12937.2 ESA03893.1 - 0.02 14.6 1.7 0.044 13.5 1.2 1.5 1 0 0 1 1 1 0 F-box-like NinE PF05322.6 ESA03893.1 - 0.23 11.2 5.8 4.7 7.0 0.3 3.1 2 1 0 2 2 2 0 NINE Protein Sel1 PF08238.7 ESA03895.1 - 6e-186 598.8 32.2 3.3e-10 40.2 0.1 20.2 20 0 0 20 20 20 20 Sel1 repeat zf-BED PF02892.10 ESA03895.1 - 4.4e-11 42.3 4.9 1.6e-06 27.7 0.3 3.0 2 0 0 2 2 2 2 BED zinc finger TPR_6 PF13174.1 ESA03895.1 - 4.1e-09 36.2 18.5 1.1 9.8 0.0 12.6 16 0 0 16 16 16 1 Tetratricopeptide repeat PyrI_C PF02748.10 ESA03895.1 - 2.2e-05 23.7 0.9 0.16 11.4 0.1 2.9 2 0 0 2 2 2 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.1 ESA03895.1 - 0.019 15.2 6.6 0.83 10.1 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-TRAF PF02176.13 ESA03895.1 - 0.97 9.8 8.3 0.21 11.9 1.0 2.6 2 0 0 2 2 2 0 TRAF-type zinc finger DUF4064 PF13273.1 ESA03896.1 - 0.042 13.9 2.4 0.074 13.1 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Kelch_5 PF13854.1 ESA03897.1 - 0.048 13.6 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Kelch motif TBSV_P22 PF03558.8 ESA03897.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 TBSV core protein P21/P22 DUF4375 PF14300.1 ESA03898.1 - 0.0016 18.3 0.7 0.002 18.1 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4375) Imm22 PF15592.1 ESA03898.1 - 0.0034 17.6 0.2 0.0059 16.9 0.1 1.3 1 1 0 1 1 1 1 Immunity protein 22 DUF4093 PF13331.1 ESA03898.1 - 0.018 15.2 0.5 0.022 14.9 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) DUF3829 PF12889.2 ESA03898.1 - 0.045 12.9 1.6 0.045 12.9 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Chordopox_L2 PF05803.7 ESA03898.1 - 0.15 11.7 0.7 0.23 11.0 0.5 1.3 1 0 0 1 1 1 0 Chordopoxvirus L2 protein NYD-SP28_assoc PF14775.1 ESA03898.1 - 0.23 11.1 2.6 0.27 10.9 1.4 1.5 1 1 0 1 1 1 0 Sperm tail C-terminal domain GvpG PF05120.7 ESA03898.1 - 0.28 11.0 5.0 0.36 10.6 0.3 2.1 1 1 1 2 2 2 0 Gas vesicle protein G NUMOD1 PF07453.8 ESA03899.1 - 0.15 11.9 0.6 4.2 7.3 0.1 2.9 2 1 1 3 3 3 0 NUMOD1 domain DUF1664 PF07889.7 ESA03900.1 - 0.011 15.5 0.2 0.014 15.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Mod_r PF07200.8 ESA03900.1 - 0.025 14.5 2.9 0.034 14.0 2.0 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF3544 PF12064.3 ESA03900.1 - 0.052 13.3 0.1 0.06 13.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3544) TMF_TATA_bd PF12325.3 ESA03900.1 - 0.062 13.0 3.1 0.079 12.6 2.2 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding VanW PF04294.8 ESA03900.1 - 0.07 12.3 0.0 3.8 6.7 0.0 2.1 2 0 0 2 2 2 0 VanW like protein Leu_zip PF15294.1 ESA03900.1 - 0.27 10.2 8.9 0.36 9.8 6.1 1.0 1 0 0 1 1 1 0 Leucine zipper NPV_P10 PF05531.7 ESA03900.1 - 0.46 10.7 2.7 1.7 8.9 1.9 1.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Trypan_glycop PF00913.14 ESA03900.1 - 3.5 6.4 6.2 4.4 6.1 4.3 1.0 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Asp_protease_2 PF13650.1 ESA03903.1 - 0.0042 17.5 0.0 0.0064 16.9 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA03903.1 - 0.0073 16.2 0.2 0.014 15.2 0.1 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA03903.1 - 0.11 12.3 0.0 0.35 10.7 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease TSC22 PF01166.13 ESA03904.1 - 0.091 12.7 0.6 1.8 8.6 0.1 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Piwi PF02171.12 ESA03907.1 - 1.5e-99 332.7 0.0 2.4e-99 332.1 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA03907.1 - 1.2e-27 95.8 0.1 3.1e-27 94.5 0.1 1.6 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA03907.1 - 5.2e-16 57.7 0.0 1.5e-15 56.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) tRNA_anti-codon PF01336.20 ESA03908.1 - 0.077 12.8 0.1 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF4367 PF14285.1 ESA03909.1 - 0.0012 18.1 1.9 0.0035 16.6 1.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) DDE_3 PF13358.1 ESA03909.1 - 0.035 13.8 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 DDE superfamily endonuclease PCNP PF15473.1 ESA03909.1 - 0.066 13.5 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family Sporozoite_P67 PF05642.6 ESA03910.1 - 2.8 5.7 5.2 4 5.1 3.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.4 ESA03910.1 - 5 5.7 11.6 7.4 5.1 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRM_1 PF00076.17 ESA03911.1 - 0.00034 20.1 0.0 0.001 18.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03911.1 - 0.0069 16.3 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Herpes_UL73 PF03554.8 ESA03912.1 - 0.037 13.8 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein MARVEL PF01284.18 ESA03913.1 - 0.86 9.4 8.3 2.1 8.1 5.8 1.7 1 1 0 1 1 1 0 Membrane-associating domain DUF4234 PF14018.1 ESA03913.1 - 1.7 8.4 6.3 0.19 11.4 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) PX PF00787.19 ESA03914.1 - 1.7e-05 24.5 0.2 3.7e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 PX domain NTP_transf_2 PF01909.18 ESA03915.1 - 0.013 15.7 0.1 0.029 14.6 0.0 1.7 2 0 0 2 2 2 0 Nucleotidyltransferase domain RRM_1 PF00076.17 ESA03917.1 - 4.4e-05 23.0 0.0 0.00014 21.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA03917.1 - 4.5e-05 23.1 0.0 8.7e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA03917.1 - 0.0034 17.3 0.0 0.01 15.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA03917.1 - 0.0038 17.0 0.0 0.015 15.1 0.0 2.1 1 1 0 1 1 1 1 RNA binding motif WD40 PF00400.27 ESA03918.1 - 4e-61 200.8 16.4 5.3e-10 38.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA03918.1 - 0.001 17.3 5.9 0.27 9.3 3.8 3.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 PD40 PF07676.7 ESA03918.1 - 0.024 14.2 0.1 3.8 7.2 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 ESA03918.1 - 0.046 12.0 0.2 0.28 9.4 0.1 1.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain Nucleoporin_N PF08801.6 ESA03918.1 - 0.075 11.7 1.9 1.4 7.6 1.3 2.8 1 1 0 1 1 1 0 Nup133 N terminal like PPR_2 PF13041.1 ESA03920.1 - 4.9e-13 48.8 0.0 3.5e-12 46.0 0.0 2.0 1 1 1 2 2 2 1 PPR repeat family PPR PF01535.15 ESA03920.1 - 4e-06 26.4 0.2 0.00047 19.9 0.0 3.0 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.1 ESA03920.1 - 6.1e-05 22.9 0.0 0.0057 16.8 0.0 2.4 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA03920.1 - 0.00014 21.2 0.1 0.47 9.9 0.0 2.6 3 0 0 3 3 3 2 PPR repeat ECSIT PF06239.6 ESA03920.1 - 0.0028 16.5 0.1 0.0089 14.9 0.0 1.7 1 1 1 2 2 2 1 Evolutionarily conserved signalling intermediate in Toll pathway Pox_VLTF3 PF04947.9 ESA03920.1 - 0.0085 15.6 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Poxvirus Late Transcription Factor VLTF3 like CBFD_NFYB_HMF PF00808.18 ESA03921.1 - 1.4e-29 101.9 0.7 2e-29 101.4 0.5 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESA03921.1 - 1.2e-06 28.5 0.1 1.6e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 ESA03921.1 - 0.0013 18.4 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIID_20kDa PF03847.8 ESA03921.1 - 0.022 15.0 0.2 0.67 10.2 0.0 2.3 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Bromo_TP PF07524.8 ESA03921.1 - 0.027 14.2 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated CAML PF14963.1 ESA03921.1 - 0.095 12.0 0.7 0.12 11.6 0.5 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand CENP-X PF09415.5 ESA03921.1 - 0.24 11.2 1.2 0.32 10.8 0.1 1.8 2 0 0 2 2 2 0 CENP-S associating Centromere protein X PARP PF00644.15 ESA03922.1 - 5.8e-09 35.6 1.7 1.7e-08 34.1 0.4 2.1 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PTS_2-RNA PF01885.11 ESA03922.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family LRAT PF04970.8 ESA03923.1 - 6.4e-12 45.5 0.0 1.4e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Fib_alpha PF08702.5 ESA03924.1 - 0.82 9.7 7.2 1.2 9.3 0.9 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family LRR_6 PF13516.1 ESA03924.1 - 2 8.7 9.9 2.2 8.5 0.6 4.5 4 1 0 4 4 4 0 Leucine Rich repeat Pkinase PF00069.20 ESA03926.1 - 5e-29 101.2 0.0 5.5e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03926.1 - 1.5e-27 96.2 0.0 1.6e-27 96.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA03926.1 - 0.017 14.8 0.1 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA03927.1 - 0.001 18.2 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PipA PF07108.6 ESA03928.1 - 0.11 11.8 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 PipA protein Prosystemin PF07376.6 ESA03928.1 - 0.12 11.7 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Prosystemin TFIIF_alpha PF05793.7 ESA03929.1 - 0.089 11.1 10.3 0.12 10.7 7.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Secretin_N_2 PF07655.8 ESA03929.1 - 0.6 10.5 8.8 0.15 12.4 2.9 1.9 1 1 1 2 2 2 0 Secretin N-terminal domain MULE PF10551.4 ESA03932.1 - 5e-08 32.9 0.1 2.7e-07 30.6 0.1 2.2 2 0 0 2 2 2 1 MULE transposase domain P22_AR_C PF10548.4 ESA03932.1 - 0.045 13.6 0.6 6.2 6.7 0.0 3.4 3 0 0 3 3 3 0 P22AR C-terminal domain ALIX_LYPXL_bnd PF13949.1 ESA03932.1 - 0.046 12.6 0.3 0.25 10.2 0.1 2.2 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Myb_DNA-bind_3 PF12776.2 ESA03932.1 - 0.27 11.8 3.3 0.42 11.2 0.8 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Kelch_5 PF13854.1 ESA03935.1 - 1e-13 50.8 6.8 3.5e-08 33.2 0.4 2.7 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESA03935.1 - 4.6e-11 42.2 3.7 8.3e-10 38.2 0.3 2.6 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA03935.1 - 7.6e-09 34.9 0.1 3.6e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 ESA03935.1 - 5.7e-08 32.7 5.3 1.8e-05 24.7 0.3 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA03935.1 - 4.2e-05 23.5 2.1 0.0011 19.0 0.4 2.4 1 1 1 2 2 2 1 Kelch motif Kelch_1 PF01344.20 ESA03935.1 - 0.0083 15.6 6.0 0.019 14.4 1.1 2.6 2 1 0 2 2 2 1 Kelch motif Glycophorin_A PF01102.13 ESA03935.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycophorin A Hrs_helical PF12210.3 ESA03938.1 - 0.042 14.1 0.0 0.059 13.6 0.0 1.2 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Phage_GP20 PF06810.6 ESA03938.1 - 0.042 13.2 2.8 0.055 12.9 1.9 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF244 PF03112.9 ESA03938.1 - 0.11 12.0 2.9 0.1 12.1 0.6 1.9 2 0 0 2 2 2 0 Uncharacterized protein family (ORF7) DUF HSBP1 PF06825.7 ESA03938.1 - 0.29 10.7 3.6 0.29 10.7 1.7 1.6 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Uds1 PF15456.1 ESA03939.1 - 2.5e-07 30.7 0.1 2.5e-07 30.7 0.1 1.7 2 0 0 2 2 2 1 Up-regulated During Septation NP1-WLL PF11733.3 ESA03939.1 - 0.092 13.0 0.4 0.092 13.0 0.3 2.2 2 1 0 2 2 2 0 Non-capsid protein NP1 TRAPPC10 PF12584.3 ESA03940.1 - 9.7e-22 77.0 0.1 2.3e-21 75.8 0.1 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.3 ESA03940.1 - 5.8e-06 25.9 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.2 ESA03940.1 - 0.029 14.1 0.0 0.23 11.3 0.0 2.6 3 0 0 3 3 3 0 Gryzun, putative Golgi trafficking Thioredoxin_8 PF13905.1 ESA03940.1 - 0.058 13.5 1.5 1 9.5 0.1 3.3 3 0 0 3 3 3 0 Thioredoxin-like Hydantoinase_B PF02538.9 ESA03941.1 - 3.7e-196 652.4 0.0 5.1e-196 651.9 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 ESA03941.1 - 7.8e-95 317.3 0.1 2.4e-94 315.7 0.0 1.9 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 ESA03941.1 - 1.1e-57 194.3 0.1 3.1e-55 186.3 0.0 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region SCAMP PF04144.8 ESA03943.1 - 0.067 13.0 0.7 0.13 12.1 0.5 1.4 1 0 0 1 1 1 0 SCAMP family FAD_binding_3 PF01494.14 ESA03944.1 - 1.5e-05 24.2 0.1 0.00053 19.1 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Myb_DNA-binding PF00249.26 ESA03946.1 - 1.1e-10 41.3 0.0 2.1e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA03946.1 - 5.8e-07 29.5 0.0 8.8e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Birna_VP3 PF01767.11 ESA03946.1 - 0.11 12.1 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Birnavirus VP3 protein Sel1 PF08238.7 ESA03948.1 - 3.4e-131 424.8 52.5 1.1e-12 48.0 0.6 13.0 13 0 0 13 13 13 12 Sel1 repeat TPR_17 PF13431.1 ESA03948.1 - 1.7e-25 87.0 32.2 0.012 15.7 0.1 13.6 10 3 2 13 13 13 9 Tetratricopeptide repeat TPR_6 PF13174.1 ESA03948.1 - 6.3e-17 60.7 46.1 0.27 11.7 0.1 12.5 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_11 PF13414.1 ESA03948.1 - 8.3e-17 60.5 55.0 0.0011 18.5 0.8 9.1 1 1 8 10 10 10 7 TPR repeat TPR_16 PF13432.1 ESA03948.1 - 8.2e-11 42.2 13.2 0.046 14.4 0.1 8.1 2 2 8 10 10 10 4 Tetratricopeptide repeat TPR_20 PF14561.1 ESA03948.1 - 2.3e-10 40.4 4.6 6.4 6.9 0.0 8.6 2 2 8 10 10 10 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA03948.1 - 2.2e-09 37.1 32.2 0.053 13.4 0.5 8.7 1 1 10 11 11 11 7 Tetratricopeptide repeat MIT PF04212.13 ESA03948.1 - 6.3e-08 32.3 34.9 0.65 9.9 0.5 9.7 9 1 1 10 10 10 4 MIT (microtubule interacting and transport) domain TPR_19 PF14559.1 ESA03948.1 - 1.4e-06 28.4 16.1 11 6.5 0.0 9.1 8 2 3 11 11 10 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA03948.1 - 0.014 14.9 73.0 0.24 11.0 0.1 16.5 17 2 2 19 19 18 0 Tetratricopeptide repeat CitT PF12431.3 ESA03948.1 - 0.042 13.9 5.9 36 4.5 0.0 6.4 6 0 0 6 6 6 0 Transcriptional regulator TPR_2 PF07719.12 ESA03948.1 - 0.08 12.8 90.0 0.48 10.4 0.1 17.3 17 4 1 18 18 17 0 Tetratricopeptide repeat PocR PF10114.4 ESA03948.1 - 0.39 9.8 6.2 20 4.2 0.0 4.1 2 1 1 4 4 4 0 Sensory domain found in PocR DUF3674 PF12426.3 ESA03948.1 - 0.53 9.7 23.2 2.6 7.5 0.0 8.1 9 0 0 9 9 9 0 RNA dependent RNA polymerase Ank_2 PF12796.2 ESA03948.1 - 1 9.7 8.3 1.4e+02 2.9 5.7 3.6 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) DUF577 PF04510.7 ESA03948.1 - 1.1 8.8 8.7 18 4.9 0.0 5.8 4 2 4 8 8 8 0 Family of unknown function (DUF577) RAI16-like PF10257.4 ESA03951.1 - 3.5e-41 141.3 2.3 3.5e-41 141.3 1.6 1.6 2 0 0 2 2 2 1 Retinoic acid induced 16-like protein Pkinase_Tyr PF07714.12 ESA03952.1 - 1.6e-13 50.3 0.0 2.6e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA03952.1 - 1.8e-11 43.6 0.0 3.2e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 ESA03952.1 - 9.1e-09 34.6 0.0 0.13 12.4 0.0 5.7 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.15 ESA03952.1 - 4.3e-05 22.0 1.2 6.1e-05 21.5 0.4 1.5 2 0 0 2 2 2 1 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 ESA03952.1 - 0.0023 18.2 0.3 9.2 6.7 0.0 3.3 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region Kinase-like PF14531.1 ESA03952.1 - 0.025 13.5 0.0 0.047 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Cnd1 PF12717.2 ESA03952.1 - 0.038 13.8 0.3 0.37 10.6 0.0 2.5 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.2 ESA03952.1 - 0.055 13.4 0.0 0.57 10.2 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.1 ESA03952.1 - 0.059 13.8 0.0 1.1 9.8 0.0 3.0 3 1 0 3 3 3 0 HEAT-like repeat OmdA PF13376.1 ESA03952.1 - 0.094 12.3 0.3 0.23 11.1 0.1 1.7 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated RRP7 PF12923.2 ESA03953.1 - 0.054 13.5 5.3 0.13 12.3 1.7 2.2 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) FliG_N PF14842.1 ESA03954.1 - 0.019 15.0 0.3 0.041 14.0 0.2 1.5 1 0 0 1 1 1 0 FliG N-terminal domain TFIIA_gamma_N PF02268.11 ESA03954.1 - 0.072 12.6 0.1 16 5.1 0.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF3328 PF11807.3 ESA03960.1 - 0.066 12.8 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Epsilon_antitox PF08998.6 ESA03960.1 - 0.072 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial epsilon antitoxin Calici_coat PF00915.15 ESA03961.1 - 0.13 11.1 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein DUF2591 PF10765.4 ESA03962.1 - 0.31 11.2 2.0 0.39 10.9 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2591) E2F_TDP PF02319.15 ESA03962.1 - 2.6 7.6 6.1 12 5.5 0.0 3.4 2 1 1 3 3 3 0 E2F/DP family winged-helix DNA-binding domain DUF2963 PF11178.3 ESA03962.1 - 7.5 6.0 12.0 25 4.3 3.5 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) SRP_SPB PF02978.14 ESA03963.1 - 0.067 13.4 6.0 0.11 12.8 2.3 2.6 1 1 1 2 2 2 0 Signal peptide binding domain CDC37_C PF08564.5 ESA03963.1 - 0.29 10.9 5.2 0.54 10.1 2.0 2.5 2 0 0 2 2 2 0 Cdc37 C terminal domain OTT_1508_deam PF14441.1 ESA03964.1 - 8.1e-13 48.3 0.2 1.8e-12 47.2 0.1 1.7 1 0 0 1 1 1 1 OTT_1508-like deaminase dCMP_cyt_deam_1 PF00383.17 ESA03964.1 - 0.0054 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.1 ESA03964.1 - 0.0066 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase TLD PF07534.11 ESA03966.1 - 7.2e-11 42.2 2.8 7.2e-11 42.2 1.9 1.5 2 0 0 2 2 2 1 TLD Sulfate_transp PF00916.15 ESA03967.1 - 8.4e-58 195.5 12.0 2.1e-46 158.2 3.0 2.6 2 1 1 3 3 3 2 Sulfate transporter family Sulfate_tra_GLY PF13792.1 ESA03967.1 - 6.5e-30 102.6 3.1 6.5e-30 102.6 2.1 2.5 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 ESA03967.1 - 5.1e-15 54.9 0.1 1e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain Tom22 PF04281.8 ESA03968.1 - 3.9 7.0 16.1 16 5.0 11.2 2.2 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Pkinase PF00069.20 ESA03969.1 - 9.3e-38 129.8 1.5 1.3e-37 129.3 1.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA03969.1 - 8.5e-25 87.2 0.3 1.2e-24 86.8 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA03969.1 - 1.6e-05 24.0 0.1 0.00015 20.7 0.0 2.3 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 ESA03969.1 - 0.00049 19.2 0.0 0.00081 18.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA03969.1 - 0.015 15.0 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Syja_N PF02383.13 ESA03969.1 - 0.023 13.4 0.1 0.038 12.7 0.1 1.4 1 0 0 1 1 1 0 SacI homology domain RIO1 PF01163.17 ESA03969.1 - 0.028 13.7 0.1 0.081 12.2 0.0 1.7 1 0 0 1 1 1 0 RIO1 family CTD_bind PF04818.8 ESA03971.1 - 3.1e-09 36.9 0.8 1.3e-08 34.9 0.0 2.4 2 1 0 2 2 2 1 RNA polymerase II-binding domain. VitD-bind_III PF09164.5 ESA03971.1 - 0.033 13.7 0.3 0.1 12.2 0.0 2.0 2 1 0 2 2 2 0 Vitamin D binding protein, domain III DUF913 PF06025.7 ESA03971.1 - 0.12 11.1 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Mlp PF03304.8 ESA03971.1 - 0.12 12.3 0.5 6.1 6.8 0.0 2.4 2 1 1 3 3 3 0 Mlp lipoprotein family TIP41 PF04176.8 ESA03972.1 - 0.039 13.2 0.1 0.04 13.1 0.1 1.0 1 0 0 1 1 1 0 TIP41-like family COX6B PF02297.12 ESA03973.1 - 8.8e-17 60.8 3.8 1.2e-16 60.5 2.7 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.8 ESA03973.1 - 0.013 15.3 1.8 0.043 13.7 1.2 1.9 1 1 0 1 1 1 0 CHCH domain APOBEC_C PF05240.9 ESA03973.1 - 0.047 13.1 2.8 0.054 12.8 1.3 1.7 1 1 1 2 2 2 0 APOBEC-like C-terminal domain UCR_hinge PF02320.11 ESA03973.1 - 0.12 12.3 0.2 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein UPF0203 PF05254.7 ESA03973.1 - 2.8 7.8 5.7 11 5.9 0.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) MOZ_SAS PF01853.13 ESA03974.1 - 9.8e-70 233.6 2.4 9.8e-70 233.6 1.7 1.7 2 0 0 2 2 2 1 MOZ/SAS family Tudor-knot PF11717.3 ESA03974.1 - 1.5e-11 43.8 1.6 2.8e-11 42.9 1.1 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.1 ESA03974.1 - 0.018 15.1 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Chromo PF00385.19 ESA03974.1 - 0.031 13.9 0.1 0.078 12.6 0.1 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain FR47 PF08445.5 ESA03974.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein FbpA PF05833.6 ESA03975.1 - 9.5e-51 172.7 20.4 9.5e-51 172.7 14.1 2.5 4 0 0 4 4 4 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.3 ESA03975.1 - 1.5e-31 108.3 0.4 8.3e-31 105.9 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 ESA03975.1 - 4.3e-23 81.0 0.0 1.1e-22 79.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Aldedh PF00171.17 ESA03976.1 - 3.7e-87 292.6 0.0 4.3e-87 292.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TrkA_C PF02080.16 ESA03978.1 - 0.073 12.6 0.8 16 5.1 0.0 3.3 1 1 3 4 4 4 0 TrkA-C domain DUF336 PF03928.9 ESA03978.1 - 0.82 9.4 8.5 6.9 6.4 0.0 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF336) F-box-like PF12937.2 ESA03979.1 - 0.0013 18.3 0.4 0.0052 16.4 0.2 2.1 1 0 0 1 1 1 1 F-box-like ATP-synt_ab_C PF00306.22 ESA03979.1 - 0.011 16.2 0.2 0.033 14.6 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain LRR_4 PF12799.2 ESA03979.1 - 0.04 13.5 17.9 2.9 7.6 0.1 6.7 4 2 4 8 8 8 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA03979.1 - 0.78 9.9 18.5 27 5.2 0.0 7.3 7 1 0 7 7 7 0 Leucine Rich repeat AAA_22 PF13401.1 ESA03980.1 - 0.00054 20.1 0.0 0.0024 18.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA03980.1 - 0.00073 19.4 3.5 0.0018 18.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain Birna_VP2 PF01766.12 ESA03980.1 - 0.002 17.1 2.1 0.0083 15.0 0.0 2.1 2 0 0 2 2 2 1 Birnavirus VP2 protein AAA PF00004.24 ESA03980.1 - 0.017 15.3 0.0 0.11 12.6 0.0 2.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) VIT1 PF01988.14 ESA03981.1 - 0.035 13.5 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 VIT family MAT1 PF06391.8 ESA03981.1 - 1.7 8.1 15.6 2.5 7.6 10.8 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 CPSF73-100_C PF11718.3 ESA03981.1 - 2.1 7.6 6.5 3.2 7.0 4.5 1.4 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term YesK PF14150.1 ESA03982.1 - 1.6 8.9 4.4 3.4 7.8 1.9 1.9 1 1 1 2 2 2 0 YesK-like protein LMBR1 PF04791.11 ESA03983.1 - 1.2e-16 60.3 30.4 1e-13 50.7 9.3 2.2 1 1 1 2 2 2 2 LMBR1-like membrane protein DUF3290 PF11694.3 ESA03983.1 - 8.6 6.0 9.0 0.36 10.5 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) WD40 PF00400.27 ESA03984.1 - 3e-26 90.2 16.9 2.8e-05 23.8 0.7 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA03984.1 - 2.1e-07 30.8 2.3 7.7e-06 25.7 0.5 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A MT-A70 PF05063.9 ESA03985.1 - 4.9e-17 62.0 0.0 7.5e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Prp19_bind PF06991.6 ESA03986.1 - 2.1e-85 286.3 39.4 2.1e-85 286.3 27.3 2.1 1 1 1 2 2 2 1 Splicing factor, Prp19-binding domain Cylicin_N PF15241.1 ESA03986.1 - 0.71 9.7 7.3 2.4 8.0 0.4 2.9 2 1 0 2 2 2 0 Cylicin N-terminus MFS_1_like PF12832.2 ESA03987.1 - 4.4e-11 42.4 0.1 4.4e-11 42.4 0.1 3.7 3 1 1 4 4 4 1 MFS_1 like family SURF4 PF02077.10 ESA03988.1 - 3.2e-95 318.5 8.4 3.7e-95 318.3 5.8 1.0 1 0 0 1 1 1 1 SURF4 family HR_lesion PF05514.6 ESA03988.1 - 0.024 14.4 2.6 0.024 14.4 1.8 2.8 3 1 0 3 3 3 0 HR-like lesion-inducing DUF1206 PF06724.6 ESA03988.1 - 2.4 7.9 11.3 0.64 9.8 0.8 3.3 2 2 1 3 3 3 0 Domain of Unknown Function (DUF1206) TRAP_alpha PF03896.11 ESA03989.1 - 1.6e-18 66.7 2.9 1.9e-18 66.4 2.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit zf-CCHC_4 PF14392.1 ESA03991.1 - 0.001 18.6 1.0 0.002 17.7 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 ESA03991.1 - 0.0027 17.5 3.3 0.004 17.0 2.3 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.1 ESA03991.1 - 0.024 14.3 9.4 0.041 13.5 6.5 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-MYND PF01753.13 ESA03992.1 - 4e-08 33.0 16.3 1.1e-07 31.6 11.3 1.8 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.11 ESA03992.1 - 0.09 12.4 13.0 0.25 11.0 9.0 1.8 1 0 0 1 1 1 0 HIT zinc finger DUF3844 PF12955.2 ESA03992.1 - 0.95 9.5 7.4 0.19 11.8 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3844) DUF3439 PF11921.3 ESA03993.1 - 0.11 12.2 13.0 0.15 11.7 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4512 PF14975.1 ESA03993.1 - 0.17 12.7 4.0 0.29 11.9 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) Med3 PF11593.3 ESA03993.1 - 3.7 6.6 8.3 4.9 6.2 5.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MaoC_dehydrat_N PF13452.1 ESA03994.1 - 0.00053 19.7 0.0 0.0013 18.5 0.0 1.7 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase CBF PF03914.12 ESA03995.1 - 5.2e-47 159.3 0.2 1.6e-46 157.7 0.1 1.9 1 0 0 1 1 1 1 CBF/Mak21 family Adaptin_N PF01602.15 ESA03995.1 - 0.0071 14.7 0.6 3.1 6.0 0.1 2.8 2 1 0 2 2 2 2 Adaptin N terminal region ECH PF00378.15 ESA03996.1 - 1.2e-31 109.7 0.2 1.9e-31 109.1 0.1 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Sec5 PF15469.1 ESA03997.1 - 4.2e-62 209.1 2.0 4.2e-62 209.1 1.4 2.4 3 0 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.6 ESA03997.1 - 2.5e-06 27.2 0.6 1.3e-05 24.9 0.1 2.6 2 0 0 2 2 2 1 Vps51/Vps67 Sds3 PF08598.6 ESA03997.1 - 0.029 13.9 2.5 0.065 12.7 1.7 1.6 1 1 0 1 1 1 0 Sds3-like MCM_N PF14551.1 ESA03997.1 - 1.6 9.2 10.3 0.27 11.7 0.7 3.8 4 1 1 5 5 5 0 MCM N-terminal domain Mito_carr PF00153.22 ESA03998.1 - 3.4e-61 202.9 3.1 3e-21 74.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Patatin PF01734.17 ESA03998.1 - 2 8.3 5.1 51 3.6 3.5 2.2 1 1 0 1 1 1 0 Patatin-like phospholipase DUF663 PF04950.7 ESA03999.1 - 3.1e-111 371.0 0.0 6.4e-111 370.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 ESA03999.1 - 4e-21 74.3 0.0 1e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain BCDHK_Adom3 PF10436.4 ESA04000.1 - 6.7e-44 149.2 0.0 4.6e-43 146.5 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESA04000.1 - 6.3e-09 35.5 0.0 5.2e-08 32.5 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESA04000.1 - 0.064 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF947 PF06102.7 ESA04002.1 - 3.6e-47 160.3 33.2 3.6e-47 160.3 23.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF947) DUF2890 PF11081.3 ESA04002.1 - 0.99 9.4 20.7 2 8.4 14.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2890) ADH_zinc_N PF00107.21 ESA04003.1 - 1.7e-16 59.9 0.0 3.6e-16 58.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA04003.1 - 0.0034 17.1 0.0 0.0082 15.8 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Kelch_5 PF13854.1 ESA04005.1 - 3.1e-19 68.4 10.1 0.01 15.7 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA04005.1 - 3e-18 65.3 19.0 0.0015 18.2 0.1 6.4 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA04005.1 - 4.3e-17 61.7 6.4 0.015 15.4 0.2 7.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA04005.1 - 1.1e-14 53.6 29.2 0.00045 19.7 0.9 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESA04005.1 - 1.5e-14 53.4 19.2 0.006 16.7 0.3 6.6 5 2 1 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESA04005.1 - 2.9e-10 39.4 7.1 0.22 11.3 0.0 6.3 5 1 1 6 6 6 3 Kelch motif HHH_3 PF12836.2 ESA04006.1 - 1.6e-06 27.9 0.8 2.3e-06 27.4 0.2 1.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_6 PF14579.1 ESA04006.1 - 0.00026 20.9 0.0 0.00034 20.6 0.0 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF655 PF04919.7 ESA04006.1 - 0.00093 18.9 0.1 0.0011 18.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF655) WD40 PF00400.27 ESA04007.1 - 4.8e-30 102.3 10.5 6.6e-11 41.6 1.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat BTB PF00651.26 ESA04010.1 - 6.3e-11 42.2 0.5 1.2e-10 41.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA04010.1 - 9.6e-05 22.4 0.2 0.00021 21.3 0.1 1.6 1 0 0 1 1 1 1 SPRY domain FIST PF08495.5 ESA04011.1 - 5e-05 22.5 0.0 0.00015 21.0 0.0 1.7 2 0 0 2 2 2 1 FIST N domain Tub_2 PF04525.7 ESA04011.1 - 0.027 13.8 0.6 0.42 9.9 0.0 2.2 1 1 1 2 2 2 0 Tubby C 2 Pro_isomerase PF00160.16 ESA04011.1 - 0.3 11.2 2.2 20 5.3 1.6 2.4 1 1 0 1 1 1 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BTB PF00651.26 ESA04012.1 - 4.2e-07 29.9 0.1 6.9e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Tantalus PF15386.1 ESA04012.1 - 0.033 13.9 0.6 0.12 12.1 0.4 1.9 1 0 0 1 1 1 0 Drosophila Tantalus-like PX PF00787.19 ESA04012.1 - 0.23 11.2 2.7 0.28 10.9 0.9 1.8 1 1 1 2 2 2 0 PX domain KGK PF08872.5 ESA04012.1 - 0.47 10.6 3.7 1.1 9.3 2.5 1.7 1 1 0 1 1 1 0 KGK domain DUF4463 PF14703.1 ESA04012.1 - 0.97 9.9 5.1 0.5 10.9 1.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4463) BTB PF00651.26 ESA04013.1 - 7.1e-16 58.1 0.8 1.4e-15 57.2 0.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04013.1 - 6.1e-11 42.4 1.1 2.4e-10 40.5 0.7 2.0 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA04013.1 - 0.0094 15.7 0.1 0.029 14.1 0.1 1.9 1 1 0 1 1 1 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA04014.1 - 3.2e-08 32.9 0.0 6.4e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APP_N PF02177.11 ESA04014.1 - 0.0018 18.1 1.6 0.028 14.3 0.0 2.4 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding Adaptin_N PF01602.15 ESA04016.1 - 1.2e-112 376.9 7.0 2.8e-112 375.7 4.8 1.6 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESA04016.1 - 2.4e-16 59.7 1.0 5.2e-05 23.4 0.1 5.4 2 2 3 5 5 5 3 HEAT repeats HEAT_EZ PF13513.1 ESA04016.1 - 1.9e-06 28.1 0.7 0.0042 17.5 0.1 4.1 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.17 ESA04016.1 - 0.00035 20.4 11.9 1.7 8.9 0.1 6.6 7 0 0 7 7 7 2 HEAT repeat DUF3730 PF12530.3 ESA04016.1 - 0.0047 16.8 1.4 0.39 10.6 0.1 3.3 3 1 0 3 3 3 1 Protein of unknown function (DUF3730) HEAT_PBS PF03130.11 ESA04016.1 - 0.0058 16.9 1.0 3.4 8.4 0.0 4.8 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat CLASP_N PF12348.3 ESA04016.1 - 0.023 14.0 2.1 0.76 9.0 0.2 2.9 3 0 0 3 3 3 0 CLASP N terminal Cnd1 PF12717.2 ESA04016.1 - 0.2 11.4 9.8 2.1 8.1 0.2 4.5 2 2 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Vps51 PF08700.6 ESA04021.1 - 8e-17 60.8 0.3 8e-17 60.8 0.2 3.2 3 0 0 3 3 3 1 Vps51/Vps67 SUV3_C PF12513.3 ESA04022.1 - 5.1e-13 48.2 1.8 1.2e-12 47.0 1.2 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 ESA04022.1 - 6.1e-08 32.4 0.0 1.8e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain p450 PF00067.17 ESA04023.1 - 1.9e-36 125.5 0.1 2.2e-36 125.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MMS19_N PF14500.1 ESA04023.1 - 0.054 12.7 0.1 0.064 12.5 0.1 1.1 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Skp1_POZ PF03931.10 ESA04024.1 - 4e-18 65.2 0.0 5.8e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.26 ESA04024.1 - 0.0044 17.0 0.2 0.006 16.5 0.1 1.3 1 1 0 1 1 1 1 BTB/POZ domain DcpS_C PF11969.3 ESA04025.1 - 1.6e-28 99.2 1.0 2.8e-28 98.4 0.7 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.7 ESA04025.1 - 3.1e-25 88.7 0.0 5.6e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal E1-E2_ATPase PF00122.15 ESA04026.1 - 1.1e-37 129.2 6.4 2e-37 128.4 4.5 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESA04026.1 - 4.8e-36 125.1 0.0 8.3e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA04026.1 - 1.2e-08 35.3 0.0 2.6e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Sel1 PF08238.7 ESA04028.1 - 1.1e-34 118.1 6.6 8.7e-08 32.5 0.0 5.2 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA04028.1 - 0.012 15.4 8.5 2.8 7.8 1.0 4.0 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2097 PF09870.4 ESA04028.1 - 0.037 14.0 0.7 8.7 6.5 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2097) TPR_6 PF13174.1 ESA04028.1 - 0.081 13.4 1.0 0.99 10.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA04028.1 - 4.9 6.9 13.5 88 2.9 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA04028.1 - 8.1 6.6 13.9 34 4.6 0.2 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA04029.1 - 1.7e-74 244.5 27.9 6.1e-12 45.7 0.5 10.5 11 0 0 11 11 11 9 Sel1 repeat DUF2666 PF10869.3 ESA04029.1 - 4.9 7.1 13.9 0.28 11.2 2.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2666) PA28_beta PF02252.13 ESA04030.1 - 0.068 12.6 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit DUF2969 PF11184.3 ESA04030.1 - 0.087 12.9 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) Sel1 PF08238.7 ESA04031.1 - 7.2e-48 159.9 16.1 4.2e-12 46.2 0.9 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_20 PF14561.1 ESA04031.1 - 0.017 15.1 3.7 1.2 9.3 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA04031.1 - 0.096 12.3 21.8 1.4 8.5 1.0 4.4 1 1 3 4 4 4 0 TPR repeat MIT PF04212.13 ESA04031.1 - 0.15 11.9 16.7 0.94 9.4 3.4 4.1 1 1 3 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA04031.1 - 0.39 11.0 12.3 1.1 9.6 0.2 4.4 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA04031.1 - 0.61 10.4 9.2 22 5.5 0.2 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA04031.1 - 1.7 9.2 11.0 2.3 8.8 0.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat IBR PF01485.16 ESA04032.1 - 2.3e-19 69.0 22.1 5.5e-12 45.3 1.8 3.9 3 2 1 4 4 4 2 IBR domain zf-C3HC4_2 PF13923.1 ESA04032.1 - 0.0016 18.4 9.2 0.0016 18.4 6.4 4.6 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.12 ESA04034.1 - 0.0087 15.1 0.0 0.0088 15.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04034.1 - 0.051 12.7 0.0 0.053 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain TLD PF07534.11 ESA04036.1 - 1.4e-11 44.5 0.4 3e-11 43.4 0.3 1.6 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA04036.1 - 5.9e-07 29.4 0.0 2.2e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04036.1 - 2.5e-05 24.0 0.4 0.0057 16.4 0.1 2.9 1 1 2 3 3 3 2 BTB And C-terminal Kelch TLD PF07534.11 ESA04037.1 - 3.6e-05 23.7 0.0 6.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA04037.1 - 5.5e-05 23.1 0.5 0.012 15.6 0.0 2.8 2 1 1 3 3 3 2 BTB/POZ domain BTB PF00651.26 ESA04038.1 - 1.3e-08 34.8 0.0 1.5e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DDE_3 PF13358.1 ESA04041.1 - 0.065 12.9 0.0 0.088 12.5 0.0 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease BTB PF00651.26 ESA04042.1 - 1.4e-15 57.1 0.1 3.1e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04042.1 - 1.7e-15 57.1 2.0 1.7e-15 57.1 1.4 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04042.1 - 0.33 10.7 3.8 0.61 9.9 1.1 2.4 1 1 1 2 2 2 0 BTB And C-terminal Kelch TLD PF07534.11 ESA04043.1 - 2.5e-14 53.4 1.2 7e-14 51.9 0.8 1.8 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA04043.1 - 9e-11 41.7 0.8 1.7e-10 40.8 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain DUF904 PF06005.7 ESA04043.1 - 0.059 13.6 0.8 0.18 12.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF904) TLD PF07534.11 ESA04044.1 - 4.1e-15 56.0 1.9 9.9e-15 54.7 1.3 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA04044.1 - 7.2e-14 51.7 0.5 2.7e-13 49.8 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain RasGEF_N PF00618.15 ESA04044.1 - 0.046 13.8 0.6 0.15 12.1 0.4 1.9 1 1 0 1 1 1 0 RasGEF N-terminal motif DUF2018 PF09442.5 ESA04045.1 - 0.14 12.7 2.2 6.3 7.4 1.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) Pkinase_Tyr PF07714.12 ESA04046.1 - 1.3e-05 24.4 0.0 2.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04046.1 - 0.013 14.6 0.0 0.026 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04047.1 - 2.3e-34 118.6 0.0 4.2e-34 117.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04047.1 - 6e-30 104.2 0.2 1.7e-29 102.7 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04048.1 - 0.00014 21.0 0.1 0.00024 20.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04048.1 - 0.026 13.6 0.2 0.063 12.4 0.0 1.7 1 1 0 1 1 1 0 Protein kinase domain SGL PF08450.7 ESA04048.1 - 0.058 12.7 0.2 0.069 12.5 0.1 1.1 1 0 0 1 1 1 0 SMP-30/Gluconolaconase/LRE-like region PHD PF00628.24 ESA04049.1 - 2.3e-10 40.0 6.2 4.3e-10 39.1 4.3 1.5 1 0 0 1 1 1 1 PHD-finger Bromo_TP PF07524.8 ESA04049.1 - 5.5e-09 35.6 0.1 9.7e-09 34.8 0.1 1.4 1 0 0 1 1 1 1 Bromodomain associated PHD_2 PF13831.1 ESA04049.1 - 0.00032 19.9 3.4 0.0006 19.0 2.3 1.4 1 0 0 1 1 1 1 PHD-finger TAF8_C PF10406.4 ESA04049.1 - 0.12 12.4 2.1 0.12 12.4 0.1 2.1 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term DnaJ PF00226.26 ESA04050.1 - 4.3e-29 100.0 2.1 8.5e-29 99.0 1.4 1.5 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESA04050.1 - 5.4e-24 83.9 1.7 7e-21 73.9 0.0 2.8 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESA04050.1 - 7.1e-14 51.6 18.6 1.5e-13 50.5 12.9 1.6 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.1 ESA04050.1 - 0.0054 17.0 4.2 0.012 15.8 2.9 1.7 1 0 0 1 1 1 1 Cytochrome c3 HypA PF01155.14 ESA04050.1 - 0.054 13.1 6.8 0.64 9.7 0.4 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_3 PF14369.1 ESA04050.1 - 1.3 9.1 4.0 2.2 8.3 0.0 3.0 3 0 0 3 3 3 0 zinc-finger Pkinase PF00069.20 ESA04051.1 - 2.3e-70 236.7 0.0 3.1e-70 236.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04051.1 - 2.2e-49 167.8 0.0 3.1e-49 167.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 ESA04051.1 - 1e-21 77.0 1.1 2.7e-21 75.7 0.1 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.1 ESA04051.1 - 2.6e-06 26.6 0.0 3.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DSHCT PF08148.7 ESA04051.1 - 0.034 13.3 0.0 0.057 12.6 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.18 ESA04051.1 - 0.049 13.3 0.1 0.26 10.9 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA04051.1 - 0.062 12.3 0.2 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA04052.1 - 0.00062 18.9 0.0 0.001 18.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04052.1 - 0.068 12.3 0.8 0.34 10.0 0.0 1.9 1 1 1 2 2 2 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04053.1 - 2.3e-42 144.8 0.1 6.8e-42 143.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04053.1 - 9.7e-36 123.2 0.1 3.5e-35 121.4 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04053.1 - 0.12 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TRF PF08558.5 ESA04054.1 - 6.1e-06 25.7 4.0 6.1e-06 25.7 2.8 2.5 2 1 0 2 2 2 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 ESA04054.1 - 0.00034 20.6 0.6 0.00074 19.5 0.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA04054.1 - 0.00095 19.2 0.9 0.00095 19.2 0.6 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain HMG_box PF00505.14 ESA04055.1 - 9.3e-12 45.0 0.5 2.1e-11 43.9 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA04055.1 - 0.0016 18.7 1.7 0.0017 18.6 0.1 1.8 2 0 0 2 2 2 1 HMG-box domain Aromatic_hydrox PF11723.3 ESA04057.1 - 0.028 13.7 0.5 0.036 13.3 0.3 1.1 1 0 0 1 1 1 0 Homotrimeric ring hydroxylase COX7C PF02935.11 ESA04059.1 - 0.77 9.6 3.2 0.41 10.4 0.8 1.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc DUF4417 PF14386.1 ESA04060.1 - 0.027 13.8 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) DUF3447 PF11929.3 ESA04060.1 - 0.081 12.7 3.8 0.59 9.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Prok-RING_4 PF14447.1 ESA04061.1 - 0.028 13.9 0.1 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1861 PF08950.5 ESA04062.1 - 0.029 13.1 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) LRR_4 PF12799.2 ESA04064.1 - 8.9 6.0 11.8 0.69 9.6 0.1 4.5 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) SPRY PF00622.23 ESA04066.1 - 1.9e-21 76.4 0.2 2.8e-21 75.8 0.1 1.2 1 0 0 1 1 1 1 SPRY domain KIAA1430 PF13879.1 ESA04067.1 - 0.1 13.0 0.7 0.13 12.7 0.5 1.1 1 0 0 1 1 1 0 KIAA1430 homologue PLRV_ORF5 PF01690.12 ESA04067.1 - 1.4 7.9 4.9 1.5 7.8 3.4 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF3519 PF12033.3 ESA04068.1 - 3.4 7.9 6.8 0.22 11.7 0.6 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3519) Sel1 PF08238.7 ESA04069.1 - 5.5e-92 300.2 62.4 3e-13 49.9 1.2 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA04069.1 - 3.3e-11 42.8 36.8 0.17 12.4 0.3 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat MIT PF04212.13 ESA04069.1 - 0.00021 21.0 31.9 3.3 7.6 0.3 7.9 7 1 1 8 8 8 5 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA04069.1 - 0.0013 18.7 22.8 20 5.7 0.2 9.1 8 0 0 8 8 8 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA04069.1 - 0.029 14.1 14.2 42 3.9 0.0 7.1 8 0 0 8 8 8 0 Lung surfactant protein D coiled-coil trimerisation Phage_T4_gp19 PF06841.7 ESA04069.1 - 0.14 11.7 1.3 26 4.4 0.0 3.9 2 1 2 5 5 5 0 T4-like virus tail tube protein gp19 STE PF02200.11 ESA04069.1 - 2.2 8.4 18.1 26 5.0 0.1 6.5 2 1 5 7 7 7 0 STE like transcription factor Glyco_transf_52 PF07922.6 ESA04069.1 - 2.7 6.9 8.2 1.6 7.6 2.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase family 52 Glu_syn_central PF04898.9 ESA04069.1 - 9.4 5.3 14.6 29 3.7 0.1 5.1 2 1 4 6 6 6 0 Glutamate synthase central domain Sel1 PF08238.7 ESA04070.1 - 3.3e-124 402.6 56.2 1.2e-12 47.9 0.2 12.1 12 0 0 12 12 12 12 Sel1 repeat Flu_M1_C PF08289.6 ESA04070.1 - 2.1e-11 43.7 0.3 1.3 9.1 0.0 7.6 1 1 4 7 7 7 3 Influenza Matrix protein (M1) C-terminal domain MIT PF04212.13 ESA04070.1 - 7.3e-11 41.7 47.4 0.27 11.1 0.1 11.1 10 1 1 11 11 11 5 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA04070.1 - 1.3e-10 40.5 38.5 0.19 12.0 0.1 12.1 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_6 PF13174.1 ESA04070.1 - 2.5e-08 33.8 25.0 0.89 10.1 0.1 9.1 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA04070.1 - 1.2e-06 28.3 53.9 0.053 13.4 3.1 9.1 1 1 10 11 11 11 6 Tetratricopeptide repeat HTH_16 PF12645.2 ESA04070.1 - 6e-06 26.0 13.4 0.096 12.6 0.1 5.6 5 0 0 5 5 5 2 Helix-turn-helix domain Surfac_D-trimer PF09006.6 ESA04070.1 - 0.00019 21.0 19.1 32 4.3 0.0 9.8 11 0 0 11 11 11 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA04070.1 - 0.0014 18.7 12.4 1.4 9.0 0.1 5.9 3 2 1 6 6 6 1 Tetratricopeptide repeat UPF0270 PF06794.7 ESA04070.1 - 0.0061 16.2 0.0 12 5.7 0.0 3.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0270) PPR PF01535.15 ESA04070.1 - 0.075 13.0 10.9 22 5.3 0.0 7.3 8 0 0 8 8 8 0 PPR repeat TPR_10 PF13374.1 ESA04070.1 - 0.67 9.9 0.1 0.67 9.9 0.0 10.7 10 3 0 10 10 10 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESA04070.1 - 0.94 9.5 16.7 4.8 7.2 0.2 7.0 6 3 3 9 9 9 0 PPR repeat family FTCD_N PF07837.7 ESA04070.1 - 1.2 8.6 3.7 26 4.2 0.0 3.9 2 2 0 3 3 3 0 Formiminotransferase domain, N-terminal subdomain DUF424 PF04242.8 ESA04070.1 - 7.4 6.7 7.1 12 5.9 0.1 4.1 3 2 1 4 4 4 0 Protein of unknown function (DUF424) Sel1 PF08238.7 ESA04071.1 - 4.5e-18 65.2 1.3 1.9e-10 41.0 0.1 2.7 3 0 0 3 3 3 2 Sel1 repeat MIT PF04212.13 ESA04071.1 - 0.013 15.3 0.3 0.16 11.8 0.1 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESA04071.1 - 0.019 14.5 3.8 0.93 9.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat zinc-ribbons_6 PF07191.7 ESA04071.1 - 0.02 14.6 3.1 0.037 13.8 2.1 1.5 1 1 0 1 1 1 0 zinc-ribbons TPR_11 PF13414.1 ESA04071.1 - 0.058 13.0 3.1 0.092 12.3 2.1 1.4 1 1 0 1 1 1 0 TPR repeat NADH_u_ox_C PF12853.2 ESA04071.1 - 0.11 12.2 0.4 0.15 11.7 0.3 1.4 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit ZipA_C PF04354.8 ESA04071.1 - 0.12 11.8 0.4 1.9 7.9 0.0 2.0 1 1 1 2 2 2 0 ZipA, C-terminal FtsZ-binding domain TPR_2 PF07719.12 ESA04071.1 - 0.26 11.3 5.7 0.68 9.9 0.2 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PocR PF10114.4 ESA04071.1 - 0.48 9.5 2.8 0.76 8.9 2.0 1.3 1 0 0 1 1 1 0 Sensory domain found in PocR Sel1 PF08238.7 ESA04073.1 - 3.2e-118 383.5 71.2 2.5e-12 46.9 0.8 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_17 PF13431.1 ESA04073.1 - 0.00014 21.7 34.5 5.7 7.4 0.1 11.4 11 1 0 11 11 11 1 Tetratricopeptide repeat IL22 PF14565.1 ESA04073.1 - 0.00085 19.4 0.6 3.6 7.6 0.0 4.6 4 1 1 5 5 5 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor V-set PF07686.12 ESA04073.1 - 0.0021 17.9 17.2 1.5 8.7 0.0 7.9 2 2 7 9 9 9 1 Immunoglobulin V-set domain MIT PF04212.13 ESA04073.1 - 0.0077 16.0 48.0 6 6.8 0.3 10.1 8 2 1 10 10 10 5 MIT (microtubule interacting and transport) domain zinc-ribbons_6 PF07191.7 ESA04073.1 - 0.0099 15.6 1.1 0.0099 15.6 0.8 3.4 4 0 0 4 4 4 1 zinc-ribbons Surfac_D-trimer PF09006.6 ESA04073.1 - 0.02 14.5 17.2 60 3.4 0.0 8.2 10 0 0 10 10 10 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA04073.1 - 0.023 14.7 9.0 5.1 7.2 0.2 5.4 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA04073.1 - 0.056 13.3 30.7 7.1 6.7 0.1 10.2 10 1 0 10 10 10 0 Tetratricopeptide repeat Erythrovirus_X PF06795.6 ESA04073.1 - 0.057 13.4 0.5 4.8 7.2 0.0 4.0 4 2 2 6 6 6 0 Erythrovirus X protein TPR_6 PF13174.1 ESA04073.1 - 0.54 10.8 33.0 8.8 7.0 0.4 9.2 9 1 1 10 10 10 0 Tetratricopeptide repeat MIR PF02815.14 ESA04074.1 - 2.2e-05 24.0 0.5 0.14 11.7 0.0 3.0 1 1 2 3 3 3 2 MIR domain Ins145_P3_rec PF08709.6 ESA04074.1 - 0.034 13.1 0.1 0.31 10.0 0.0 2.0 1 1 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF659 PF04937.10 ESA04076.1 - 1.4e-10 40.8 0.0 2e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF2164 PF09932.4 ESA04076.1 - 0.14 11.9 0.1 0.48 10.2 0.0 1.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2164) Pkinase_Tyr PF07714.12 ESA04078.1 - 1.9e-34 118.9 0.0 3e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04078.1 - 3.9e-31 108.1 1.2 1.8e-30 105.9 0.8 1.9 1 1 0 1 1 1 1 Protein kinase domain AAA_8 PF12780.2 ESA04078.1 - 0.068 12.1 1.7 0.94 8.4 0.1 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 MMS19_C PF12460.3 ESA04079.1 - 0.012 14.3 0.1 0.014 14.1 0.1 1.1 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal DUF2207 PF09972.4 ESA04079.1 - 0.057 12.0 0.0 0.057 12.0 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Herpes_ori_bp PF02399.10 ESA04082.1 - 4.1e-06 25.0 0.1 7e-06 24.3 0.1 1.3 1 1 0 1 1 1 1 Origin of replication binding protein AAA_11 PF13086.1 ESA04082.1 - 0.11 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.12 ESA04083.1 - 4.7e-17 61.9 0.7 1.5e-08 34.0 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA04083.1 - 3.1e-15 56.0 0.2 1.6e-06 27.4 0.3 2.1 1 1 1 2 2 2 2 Protein kinase domain Sel1 PF08238.7 ESA04083.1 - 0.01 16.4 0.0 0.02 15.5 0.0 1.4 1 0 0 1 1 1 0 Sel1 repeat DUF1211 PF06736.6 ESA04085.1 - 0.11 12.6 0.1 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1211) Pkinase PF00069.20 ESA04086.1 - 6.4e-15 55.0 0.2 1.3e-14 53.9 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04086.1 - 2.1e-14 53.2 0.0 4.7e-14 52.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04086.1 - 0.0021 17.8 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Nucleoporin_FG PF13634.1 ESA04087.1 - 0.4 10.9 63.3 0.65 10.2 34.1 2.4 1 1 1 2 2 2 0 Nucleoporin FG repeat region HTH_22 PF13309.1 ESA04088.1 - 0.29 10.9 1.8 0.46 10.2 0.4 2.0 2 0 0 2 2 2 0 HTH domain Pkinase PF00069.20 ESA04089.1 - 2.4e-28 98.9 0.3 3.8e-28 98.3 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04089.1 - 2.9e-27 95.3 0.0 4.1e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04089.1 - 0.028 14.1 0.1 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Y_phosphatase3 PF13350.1 ESA04094.1 - 0.11 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family MSA-2c PF12238.3 ESA04094.1 - 0.11 12.1 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c Cupin_5 PF06172.6 ESA04096.1 - 7.8e-41 139.2 0.0 9.7e-41 138.9 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) zf-RING_6 PF14835.1 ESA04097.1 - 0.4 10.5 2.1 0.54 10.0 1.1 1.6 1 1 1 2 2 2 0 zf-RING of BARD1-type protein TLD PF07534.11 ESA04098.1 - 2.1e-10 40.7 3.1 6e-10 39.2 2.2 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA04098.1 - 3.3e-07 30.2 0.1 9.5e-07 28.7 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04098.1 - 4e-06 26.6 0.1 2.3e-05 24.1 0.0 2.4 1 1 0 1 1 1 1 BTB And C-terminal Kelch DMP1 PF07263.6 ESA04098.1 - 2.1 7.0 38.3 2.8 6.5 26.5 1.1 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) E1-E2_ATPase PF00122.15 ESA04100.1 - 1.4e-23 83.1 0.0 3.1e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 ESA04100.1 - 5.3e-16 59.3 0.3 1.1e-14 54.9 0.2 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA04100.1 - 1.3e-13 51.9 2.8 1.9e-10 41.5 1.3 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA04100.1 - 8.8e-13 48.0 0.0 3.2e-12 46.2 0.0 2.0 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Sel1 PF08238.7 ESA04101.1 - 8.5e-123 398.1 63.8 2.9e-12 46.8 0.7 12.3 11 1 1 12 12 12 12 Sel1 repeat Pkinase_Tyr PF07714.12 ESA04101.1 - 2.3e-40 138.2 0.0 2.4e-33 115.3 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA04101.1 - 1.8e-37 128.9 0.1 2.5e-29 102.2 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain TPR_6 PF13174.1 ESA04101.1 - 0.00011 22.4 35.1 1 9.9 0.1 9.4 10 0 0 10 10 10 4 Tetratricopeptide repeat APH PF01636.18 ESA04101.1 - 0.032 13.9 0.2 0.055 13.1 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family AHS1 PF02682.11 ESA04101.1 - 0.17 11.3 0.0 15 5.0 0.0 2.9 3 0 0 3 3 3 0 Allophanate hydrolase subunit 1 TPR_17 PF13431.1 ESA04101.1 - 0.46 10.8 33.1 12 6.4 0.2 10.9 9 2 1 10 10 10 0 Tetratricopeptide repeat HTH_16 PF12645.2 ESA04101.1 - 1.8 8.5 8.0 60 3.6 0.1 4.6 5 0 0 5 5 5 0 Helix-turn-helix domain BTB PF00651.26 ESA04102.1 - 1.4e-15 57.2 0.2 2.8e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04102.1 - 3.8e-09 36.6 0.1 7.3e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA04102.1 - 9.2e-05 22.2 1.5 0.019 14.8 0.3 3.3 2 1 1 3 3 3 2 BTB And C-terminal Kelch Glycos_transf_1 PF00534.15 ESA04102.1 - 0.061 12.7 0.3 4 6.8 0.1 2.5 2 0 0 2 2 2 0 Glycosyl transferases group 1 Urm1 PF09138.6 ESA04102.1 - 0.092 12.8 0.6 0.52 10.4 0.2 2.5 2 1 0 2 2 2 0 Urm1 (Ubiquitin related modifier) BTB PF00651.26 ESA04103.1 - 1.2e-15 57.4 0.1 1.6e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA04104.1 - 8.2e-18 64.4 0.5 1.5e-17 63.5 0.4 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04104.1 - 1e-14 54.6 2.9 3.9e-14 52.8 0.7 2.5 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA04104.1 - 1.6e-07 31.0 2.9 5.2e-06 26.2 0.3 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA04104.1 - 0.069 13.3 0.5 0.44 10.7 0.1 2.3 1 1 1 2 2 2 0 BTB/POZ domain WT1 PF02165.10 ESA04104.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Wilm's tumour protein TLD PF07534.11 ESA04105.1 - 5.5e-14 52.3 4.0 2e-13 50.5 1.6 2.5 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA04105.1 - 3.6e-09 36.6 0.1 6.5e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04105.1 - 0.00026 20.7 0.9 0.0029 17.3 0.2 2.6 2 1 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA04106.1 - 2.1e-15 56.6 0.1 4.1e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04106.1 - 7.7e-13 48.6 2.2 1.6e-12 47.5 0.8 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04106.1 - 1.5e-06 28.0 1.5 0.00015 21.5 0.1 2.8 1 1 1 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.26 ESA04107.1 - 1.3e-15 57.3 0.2 2.7e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04107.1 - 8.9e-05 22.2 1.7 0.0004 20.1 0.5 2.5 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF2661 PF10860.3 ESA04107.1 - 0.33 11.1 5.0 0.69 10.1 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2661) Pkinase_Tyr PF07714.12 ESA04112.1 - 1.7e-16 60.0 0.1 2.5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04112.1 - 6.3e-16 58.3 3.6 1.7e-15 56.8 2.5 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04112.1 - 0.2 11.3 0.1 0.29 10.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_A32 PF04665.7 ESA04113.1 - 2.4e-09 36.8 0.1 4.8e-08 32.5 0.1 2.1 1 1 0 1 1 1 1 Poxvirus A32 protein Zot PF05707.7 ESA04113.1 - 0.013 14.9 0.1 0.034 13.6 0.1 1.7 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) MobB PF03205.9 ESA04113.1 - 0.018 14.7 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 ESA04113.1 - 0.04 14.4 0.0 0.078 13.4 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein FtsK_SpoIIIE PF01580.13 ESA04113.1 - 0.056 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ESA04113.1 - 0.071 12.6 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 ESA04113.1 - 0.11 11.8 0.0 19 4.5 0.0 3.0 2 1 2 4 4 4 0 AAA-like domain Retrotrans_gag PF03732.12 ESA04114.1 - 0.024 14.6 3.0 0.059 13.4 0.0 3.2 4 0 0 4 4 4 0 Retrotransposon gag protein DUF3641 PF12345.3 ESA04114.1 - 0.036 13.9 0.4 5.6 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) Herpes_ori_bp PF02399.10 ESA04118.1 - 9.5e-14 50.3 0.0 1.5e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Origin of replication binding protein Semialdhyde_dh PF01118.19 ESA04118.1 - 0.077 13.3 0.0 5.7 7.2 0.0 3.3 3 1 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain Uma2 PF05685.7 ESA04121.1 - 2.3e-06 27.0 0.0 3.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DUF2106 PF09879.4 ESA04122.1 - 0.05 12.9 0.0 0.058 12.7 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) Nup54 PF13874.1 ESA04124.1 - 9.9e-08 31.7 2.6 0.029 14.0 0.1 3.2 1 1 2 3 3 3 3 Nucleoporin complex subunit 54 Transferrin PF00405.12 ESA04124.1 - 0.00094 18.1 2.2 0.037 12.9 0.1 2.0 1 1 1 2 2 2 2 Transferrin Intein_splicing PF14890.1 ESA04124.1 - 0.0012 17.7 5.4 0.0049 15.8 0.6 2.0 1 1 1 2 2 2 2 Intein splicing domain polyprenyl_synt PF00348.12 ESA04124.1 - 0.071 11.9 0.9 0.097 11.5 0.6 1.3 1 0 0 1 1 1 0 Polyprenyl synthetase HVSL PF09749.4 ESA04124.1 - 0.14 11.1 6.3 0.15 11.1 4.0 1.3 1 1 0 1 1 1 0 Uncharacterised conserved protein DUF3576 PF12100.3 ESA04124.1 - 0.43 10.6 4.6 24 5.0 0.1 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3576) DUF4364 PF14277.1 ESA04124.1 - 0.59 9.7 6.8 4.7 6.8 1.0 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4364) Ribosomal_L33 PF00471.15 ESA04124.1 - 0.68 10.2 21.1 2.2 8.6 0.5 4.1 4 1 0 4 4 4 0 Ribosomal protein L33 Arrestin_C PF02752.17 ESA04124.1 - 3.4 7.7 8.6 2.1e+02 2.0 5.8 2.3 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain XPA_C PF05181.7 ESA04124.1 - 4.7 6.8 6.4 66 3.2 0.1 3.3 3 0 0 3 3 3 0 XPA protein C-terminus Amino_oxidase PF01593.19 ESA04126.1 - 1.4e-10 40.8 0.0 1.8e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 ESA04126.1 - 5.6e-08 32.7 0.0 8.5e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 ESA04126.1 - 0.00096 19.2 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESA04126.1 - 0.0016 17.6 0.1 0.0021 17.1 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 ESA04126.1 - 0.012 14.5 0.2 0.016 14.1 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESA04126.1 - 0.022 13.6 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.12 ESA04126.1 - 0.027 13.5 0.0 0.037 13.1 0.0 1.1 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 ESA04126.1 - 0.034 12.6 0.1 0.05 12.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Kunitz_BPTI PF00014.18 ESA04126.1 - 0.043 14.0 0.1 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Kunitz/Bovine pancreatic trypsin inhibitor domain ThiF PF00899.16 ESA04126.1 - 0.059 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.22 ESA04126.1 - 0.064 13.6 0.1 0.32 11.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 ESA04127.1 - 2.7e-11 43.2 0.1 6.2e-06 25.5 0.0 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase Phage_holin_T PF11031.3 ESA04127.1 - 0.042 13.0 0.1 0.067 12.3 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage T holin Methyltransf_31 PF13847.1 ESA04128.1 - 0.063 12.8 0.2 0.063 12.8 0.1 2.7 2 1 0 2 2 2 0 Methyltransferase domain TLD PF07534.11 ESA04130.1 - 8.9e-14 51.6 1.4 1.2e-13 51.2 0.4 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04130.1 - 2.7e-05 23.9 1.8 0.0011 18.7 0.3 2.6 2 1 1 3 3 3 2 BTB And C-terminal Kelch RPA_interact_M PF14767.1 ESA04131.1 - 0.036 14.8 0.8 0.036 14.8 0.5 3.0 2 1 1 3 3 3 0 Replication protein A interacting middle HSBP1 PF06825.7 ESA04131.1 - 0.092 12.3 0.0 0.73 9.4 0.0 2.3 2 1 0 2 2 2 0 Heat shock factor binding protein 1 MHC_II_beta PF00969.14 ESA04131.1 - 0.19 11.7 1.1 0.34 10.9 0.1 1.7 2 1 0 2 2 2 0 Class II histocompatibility antigen, beta domain DUF4618 PF15397.1 ESA04131.1 - 0.23 10.7 12.2 0.32 10.2 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) YgaB PF14182.1 ESA04131.1 - 0.43 10.8 9.4 1.2 9.4 1.5 2.6 1 1 0 2 2 2 0 YgaB-like protein Syntaxin-6_N PF09177.6 ESA04131.1 - 0.45 10.9 4.5 16 5.9 0.1 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF2205 PF10224.4 ESA04131.1 - 0.67 9.5 6.6 0.46 10.0 0.2 2.9 2 1 1 3 3 3 0 Predicted coiled-coil protein (DUF2205) CENP-H PF05837.7 ESA04131.1 - 0.72 10.0 8.5 0.78 9.9 2.4 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ACCA PF03255.9 ESA04131.1 - 2.8 7.4 8.8 1.1 8.7 1.2 2.6 1 1 3 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF310 PF03750.8 ESA04131.1 - 3.3 7.9 7.5 3.8 7.7 0.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF310) Lge1 PF11488.3 ESA04131.1 - 3.5 7.8 6.9 3.5 7.9 1.2 2.4 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF19 PF01579.13 ESA04132.1 - 0.16 11.9 0.2 9.2 6.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF19) Pox_A32 PF04665.7 ESA04133.1 - 8.6e-10 38.3 0.7 1.5e-07 31.0 0.5 2.3 1 1 0 1 1 1 1 Poxvirus A32 protein FtsK_SpoIIIE PF01580.13 ESA04133.1 - 0.017 14.6 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Miro PF08477.8 ESA04133.1 - 0.044 14.2 0.0 0.058 13.8 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein Toxin_R_bind_C PF07951.7 ESA04133.1 - 0.12 12.0 0.2 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding Kelch_4 PF13418.1 ESA04134.1 - 0.031 14.0 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain OST3_OST6 PF04756.8 ESA04134.1 - 0.077 12.5 0.3 0.099 12.1 0.2 1.2 1 0 0 1 1 1 0 OST3 / OST6 family Kelch_5 PF13854.1 ESA04134.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.1 ESA04135.1 - 0.0031 17.4 0.1 0.0057 16.5 0.1 1.5 1 1 0 1 1 1 1 Kelch motif Kelch_6 PF13964.1 ESA04135.1 - 0.0083 16.2 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.1 ESA04135.1 - 0.019 14.7 0.2 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA04135.1 - 0.02 14.4 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.10 ESA04135.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.1 ESA04136.1 - 2.2e-13 49.7 2.7 0.0069 16.1 0.0 4.3 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA04136.1 - 1.7e-07 31.0 0.1 0.0024 17.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 ESA04136.1 - 2.3e-06 27.1 0.3 0.79 9.5 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA04136.1 - 5e-05 23.3 4.4 0.49 10.6 0.0 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA04136.1 - 5.5e-05 23.1 4.3 0.023 14.8 0.0 4.1 3 1 1 4 4 4 1 Kelch motif Kelch_1 PF01344.20 ESA04136.1 - 0.00056 19.3 1.1 0.22 11.0 0.0 2.9 3 0 0 3 3 3 2 Kelch motif DUF4211 PF13926.1 ESA04137.1 - 0.028 13.8 0.1 0.047 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4211) Myb_DNA-binding PF00249.26 ESA04138.1 - 1.1e-05 25.3 1.2 0.00055 19.9 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA04138.1 - 0.00011 22.2 2.9 0.00013 22.0 0.3 2.0 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 ESA04138.1 - 0.12 12.1 0.2 0.12 12.1 0.1 2.2 2 1 0 2 2 2 0 Rap1 Myb domain Phage_int_SAM_4 PF13495.1 ESA04138.1 - 0.2 12.0 2.1 1.3 9.4 0.2 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Myb_DNA-bind_3 PF12776.2 ESA04138.1 - 0.77 10.4 6.5 0.96 10.1 1.3 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2683 PF10884.3 ESA04139.1 - 0.034 14.0 0.7 0.051 13.4 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) LRR_4 PF12799.2 ESA04140.1 - 0.019 14.5 5.0 0.36 10.4 1.2 3.2 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA04140.1 - 0.063 13.0 1.5 0.2 11.4 0.6 2.2 1 1 1 2 2 2 0 Leucine rich repeat Kelch_4 PF13418.1 ESA04141.1 - 6.6e-05 22.5 1.6 0.049 13.4 0.0 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA04141.1 - 0.11 12.3 0.3 2 8.3 0.0 2.8 3 0 0 3 3 3 0 Kelch motif AIG1 PF04548.11 ESA04142.1 - 4.7e-09 35.6 0.0 6.7e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA04142.1 - 9.8e-09 35.1 0.1 1.8e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA04142.1 - 0.0011 18.1 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Septin PF00735.13 ESA04142.1 - 0.0031 16.5 0.0 0.0039 16.2 0.0 1.1 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.18 ESA04142.1 - 0.0031 17.3 1.3 0.32 10.7 0.0 2.5 1 1 2 3 3 3 2 Dynamin family GBP PF02263.14 ESA04142.1 - 0.012 14.7 0.1 0.022 13.7 0.0 1.4 1 1 0 1 1 1 0 Guanylate-binding protein, N-terminal domain FeoB_N PF02421.13 ESA04142.1 - 0.015 14.5 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESA04142.1 - 0.12 11.8 0.4 0.96 8.8 0.1 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain MRP-L46 PF11788.3 ESA04142.1 - 0.4 11.3 3.0 0.8 10.3 1.3 1.8 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 BAF1_ABF1 PF04684.8 ESA04143.1 - 2.1e-05 23.6 19.7 2.3e-05 23.4 13.7 1.1 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor BTV_NS2 PF04514.7 ESA04143.1 - 0.0051 15.7 2.6 0.006 15.5 1.8 1.1 1 0 0 1 1 1 1 Bluetongue virus non-structural protein NS2 Zip PF02535.17 ESA04143.1 - 0.013 14.5 2.0 0.012 14.6 1.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.12 ESA04143.1 - 0.062 13.0 6.9 0.098 12.4 4.8 1.2 1 0 0 1 1 1 0 DDHD domain EIIBC-GUT_N PF03612.9 ESA04143.1 - 0.66 9.5 6.5 1.1 8.7 4.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4175 PF13779.1 ESA04143.1 - 1.1 6.8 21.6 1.4 6.5 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SelP_N PF04592.9 ESA04143.1 - 1.2 8.4 18.1 0.048 13.0 8.6 1.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF3464 PF11947.3 ESA04143.1 - 2.1 7.8 7.0 3.7 7.0 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Pex16 PF08610.5 ESA04143.1 - 3.9 6.3 9.6 5.8 5.7 6.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF4557 PF15101.1 ESA04143.1 - 5.8 6.6 15.4 2.4 7.9 8.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) IF2_N PF04760.10 ESA04144.1 - 0.0014 18.1 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region YkuD PF03734.9 ESA04144.1 - 0.058 13.6 0.2 0.068 13.4 0.1 1.2 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain Sel1 PF08238.7 ESA04145.1 - 0.0055 17.2 0.2 0.0081 16.7 0.1 1.2 1 0 0 1 1 1 1 Sel1 repeat DUF3684 PF12449.3 ESA04146.1 - 2.9e-12 45.1 2.5 3.5e-08 31.5 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA04146.1 - 0.00024 20.7 0.1 0.47 10.0 0.0 2.6 1 1 1 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase VacJ PF04333.8 ESA04146.1 - 0.023 14.1 0.2 0.045 13.2 0.1 1.4 1 0 0 1 1 1 0 VacJ like lipoprotein Asp_protease_2 PF13650.1 ESA04148.1 - 0.00011 22.5 0.0 0.0005 20.5 0.0 2.0 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.15 ESA04148.1 - 0.0049 16.7 0.0 0.53 10.2 0.0 2.8 1 1 1 2 2 2 2 Retroviral aspartyl protease Pkinase_Tyr PF07714.12 ESA04149.1 - 1.9e-46 158.2 0.0 2.2e-46 158.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04149.1 - 4.3e-46 157.1 0.0 5.3e-46 156.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04149.1 - 0.0015 18.3 0.0 0.041 13.5 0.3 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA04149.1 - 0.012 14.7 0.1 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA04149.1 - 0.094 12.0 0.0 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Nyv1_N PF09426.5 ESA04152.1 - 0.017 14.6 0.0 0.04 13.4 0.0 1.6 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal DUF707 PF05212.7 ESA04154.1 - 0.09 11.8 0.2 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF707) HNH_4 PF13395.1 ESA04154.1 - 0.11 12.2 0.4 0.24 11.0 0.3 1.6 1 0 0 1 1 1 0 HNH endonuclease Pkinase PF00069.20 ESA04155.1 - 2.7e-05 23.4 1.1 6.8e-05 22.1 0.2 1.7 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04155.1 - 0.021 13.8 0.4 0.048 12.7 0.2 1.6 1 1 1 2 2 2 0 Protein tyrosine kinase RIO1 PF01163.17 ESA04155.1 - 0.069 12.4 0.1 0.14 11.5 0.1 1.3 1 1 0 1 1 1 0 RIO1 family Ribosomal_L6e PF01159.14 ESA04155.1 - 0.082 13.1 0.0 0.18 12.0 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L6e Surface_Ag_2 PF01617.12 ESA04155.1 - 0.083 12.0 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Surface antigen Prion PF00377.13 ESA04155.1 - 0.17 11.6 1.2 3 7.5 0.4 2.1 1 1 1 2 2 2 0 Prion/Doppel alpha-helical domain IPP-2 PF04979.9 ESA04158.1 - 0.09 13.0 0.6 0.13 12.5 0.4 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 2 (IPP-2) FtsK_SpoIIIE PF01580.13 ESA04160.1 - 0.0056 16.1 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family Pox_A32 PF04665.7 ESA04162.1 - 2.2e-06 27.1 0.0 4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Poxvirus A32 protein Zot PF05707.7 ESA04162.1 - 0.085 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) ADIP PF11559.3 ESA04163.1 - 0.011 15.5 1.3 0.011 15.5 0.9 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.6 ESA04163.1 - 0.04 13.7 9.7 0.26 11.1 6.7 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.5 ESA04163.1 - 0.23 11.6 11.4 1.1 9.4 3.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PMC2NT PF08066.7 ESA04163.1 - 0.71 10.2 3.4 12 6.2 0.1 2.9 1 1 2 3 3 3 0 PMC2NT (NUC016) domain zf-C4pol PF14260.1 ESA04163.1 - 0.97 9.4 3.9 4.6 7.3 1.4 2.3 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Med2 PF11214.3 ESA04163.1 - 1.5 8.9 7.9 0.16 12.0 0.9 2.5 1 1 1 2 2 2 0 Mediator complex subunit 2 DUF848 PF05852.6 ESA04163.1 - 1.7 8.4 9.8 0.52 10.1 3.3 2.3 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4200 PF13863.1 ESA04163.1 - 3 7.8 14.8 0.23 11.4 4.9 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Lipoprotein_20 PF13942.1 ESA04163.1 - 3.9 6.9 9.6 0.61 9.6 1.8 2.6 3 0 0 3 3 3 0 YfhG lipoprotein TMF_DNA_bd PF12329.3 ESA04163.1 - 4.5 7.1 15.5 1.1 9.1 5.6 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Tet_JBP PF12851.2 ESA04164.1 - 1e-11 44.4 0.1 2.8e-11 42.9 0.1 1.8 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily DUF605 PF04652.11 ESA04167.1 - 3.7 6.8 13.8 3.9 6.7 9.6 1.0 1 0 0 1 1 1 0 Vta1 like T4_deiodinase PF00837.12 ESA04168.1 - 6.8e-27 93.9 0.0 8.5e-27 93.6 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF2847 PF11009.3 ESA04168.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) PI31_Prot_N PF11566.3 ESA04169.1 - 0.015 14.8 1.0 0.015 14.8 0.7 1.8 2 0 0 2 2 2 0 PI31 proteasome regulator N-terminal Trehalose_PPase PF02358.11 ESA04174.1 - 1.2e-17 63.5 0.0 1.7e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase DUF2281 PF10047.4 ESA04174.1 - 0.068 13.4 0.3 0.12 12.7 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2281) Glyco_transf_20 PF00982.16 ESA04174.1 - 0.098 11.1 0.1 0.13 10.6 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 20 SPRY PF00622.23 ESA04175.1 - 0.0001 22.3 0.2 0.00012 22.1 0.1 1.0 1 0 0 1 1 1 1 SPRY domain p450 PF00067.17 ESA04176.1 - 2.2e-44 151.7 0.0 2.5e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Beach PF02138.13 ESA04176.1 - 0.031 13.7 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 Beige/BEACH domain Sel1 PF08238.7 ESA04177.1 - 5.6e-72 236.6 6.0 4.4e-12 46.2 0.1 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA04177.1 - 7e-05 23.0 1.0 1.9 9.1 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat SLT PF01464.15 ESA04177.1 - 0.0025 17.3 17.3 0.22 11.0 0.0 4.5 1 1 2 4 4 4 4 Transglycosylase SLT domain TPR_17 PF13431.1 ESA04177.1 - 0.0038 17.3 4.4 5.2 7.5 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA04177.1 - 0.006 16.1 11.0 0.12 11.9 0.3 4.7 2 1 3 5 5 5 2 TPR repeat Phage_terminase PF10668.4 ESA04177.1 - 9.1 6.1 8.5 2.2 8.1 0.1 3.7 4 1 0 4 4 4 0 Phage terminase small subunit Polyketide_cyc2 PF10604.4 ESA04180.1 - 0.12 12.5 0.0 0.13 12.4 0.0 1.0 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Hamartin PF04388.7 ESA04181.1 - 3.2e-08 32.7 0.1 4.8e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 Hamartin protein DUF2935 PF11155.3 ESA04181.1 - 0.025 14.6 0.4 0.088 12.8 0.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) TAFH PF07531.9 ESA04181.1 - 0.035 13.7 0.4 0.51 10.0 0.1 2.4 2 0 0 2 2 2 0 NHR1 homology to TAF DAGK_cat PF00781.19 ESA04181.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain TcdB_N PF12918.2 ESA04181.1 - 0.071 13.2 1.1 0.14 12.2 0.7 1.4 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Swi5 PF07061.6 ESA04181.1 - 0.1 12.3 0.8 0.21 11.3 0.2 1.8 2 0 0 2 2 2 0 Swi5 GnHR_trans PF12369.3 ESA04182.1 - 0.066 13.6 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Gonadotropin hormone receptor transmembrane region Myb_DNA-bind_4 PF13837.1 ESA04183.1 - 6e-05 23.0 8.9 0.00031 20.8 0.2 2.9 1 1 0 2 2 2 2 Myb/SANT-like DNA-binding domain PBP1_TM PF14812.1 ESA04184.1 - 0.039 14.2 7.0 0.039 14.2 4.9 1.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YvbH_ext PF11724.3 ESA04185.1 - 0.0026 17.4 0.2 0.0073 15.9 0.0 1.8 2 0 0 2 2 2 1 YvbH-like oligomerisation region NAD_binding_6 PF08030.7 ESA04185.1 - 0.037 13.9 1.6 0.043 13.7 1.1 1.2 1 0 0 1 1 1 0 Ferric reductase NAD binding domain zf-FCS PF06467.9 ESA04185.1 - 0.23 11.1 1.5 0.31 10.7 0.2 1.8 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Ank PF00023.25 ESA04187.1 - 1.5e-19 68.7 1.5 1e-10 40.8 0.1 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 ESA04187.1 - 8.5e-18 64.4 0.2 9.7e-18 64.3 0.1 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA04187.1 - 8.1e-17 61.2 0.3 2.9e-13 49.9 0.1 1.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA04187.1 - 7.1e-16 56.7 0.2 6e-08 32.1 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 ESA04187.1 - 9.1e-16 57.5 1.3 4.2e-09 36.3 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Med11 PF10280.4 ESA04188.1 - 0.032 14.2 0.2 0.071 13.1 0.1 1.5 1 0 0 1 1 1 0 Mediator complex protein DUF4200 PF13863.1 ESA04189.1 - 0.026 14.4 0.3 0.026 14.4 0.2 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4200) Herpes_BLRF2 PF05812.7 ESA04189.1 - 0.043 13.6 6.6 0.25 11.1 0.4 2.7 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein bZIP_1 PF00170.16 ESA04189.1 - 0.14 12.1 7.4 0.19 11.7 0.2 3.2 3 0 0 3 3 3 0 bZIP transcription factor HALZ PF02183.13 ESA04189.1 - 0.32 10.7 1.7 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cep57_CLD_2 PF14197.1 ESA04189.1 - 0.56 10.1 4.9 11 6.0 0.0 3.4 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 DUF1192 PF06698.6 ESA04189.1 - 0.84 9.4 4.8 0.56 10.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) TSC22 PF01166.13 ESA04189.1 - 1 9.3 15.1 2.2 8.2 0.9 3.7 4 0 0 4 4 4 0 TSC-22/dip/bun family BLOC1_2 PF10046.4 ESA04189.1 - 1.5 8.9 7.6 10 6.3 0.0 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 bZIP_2 PF07716.10 ESA04189.1 - 1.6 8.6 12.4 2.1 8.2 1.1 3.1 3 0 0 3 3 3 0 Basic region leucine zipper MIF4G_like_2 PF09090.6 ESA04189.1 - 2 7.5 13.4 0.7 9.0 1.6 2.2 2 0 0 2 2 2 0 MIF4G like DUF3347 PF11827.3 ESA04189.1 - 3.2 7.7 5.8 0.36 10.8 0.8 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3347) TMF_TATA_bd PF12325.3 ESA04189.1 - 7.1 6.3 15.4 0.17 11.6 3.2 2.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding HR1 PF02185.11 ESA04189.1 - 9.4 6.0 9.6 0.79 9.5 0.2 3.0 3 1 0 3 3 3 0 Hr1 repeat Phage_int_SAM_1 PF02899.12 ESA04191.1 - 0.088 12.9 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Toxin-deaminase PF14424.1 ESA04192.1 - 0.11 12.5 0.1 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases F-box-like PF12937.2 ESA04193.1 - 0.0028 17.3 1.7 0.0075 15.9 1.2 1.6 1 0 0 1 1 1 1 F-box-like ComZ PF10815.3 ESA04193.1 - 0.031 14.0 0.2 3.7 7.3 0.0 3.0 2 1 0 2 2 2 0 ComZ BTB PF00651.26 ESA04195.1 - 1.7e-15 56.9 0.0 2.4e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04196.1 - 5.1e-11 42.7 1.4 1e-10 41.7 1.0 1.5 1 0 0 1 1 1 1 TLD Dimer_Tnp_hAT PF05699.9 ESA04197.1 - 1.9e-15 56.2 0.0 2.2e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA04198.1 - 1e-08 34.8 0.6 2e-08 33.8 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) TM_helix PF05552.7 ESA04198.1 - 0.14 11.8 0.2 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Conserved TM helix Helitron_like_N PF14214.1 ESA04199.1 - 6.9e-24 84.5 0.0 7.3e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus DUF4298 PF14131.1 ESA04200.1 - 0.059 13.2 1.8 0.12 12.3 1.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4298) DUF972 PF06156.8 ESA04200.1 - 0.068 13.5 6.6 0.12 12.6 4.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) CASP_C PF08172.7 ESA04200.1 - 0.18 10.7 6.1 0.36 9.8 4.2 1.6 1 1 0 1 1 1 0 CASP C terminal PBP1_TM PF14812.1 ESA04200.1 - 0.27 11.5 8.8 0.53 10.6 6.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Striatin PF08232.7 ESA04200.1 - 0.39 11.0 8.9 0.72 10.1 6.2 1.4 1 0 0 1 1 1 0 Striatin family Vfa1 PF08432.5 ESA04200.1 - 6.1 6.8 14.6 17 5.4 10.1 1.7 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PWI PF01480.12 ESA04201.1 - 0.0026 17.8 3.8 4.3 7.5 0.0 3.3 1 1 2 3 3 3 3 PWI domain Fibrinogen_BP PF08017.6 ESA04201.1 - 0.0073 14.5 0.1 0.0085 14.3 0.0 1.0 1 0 0 1 1 1 1 Fibrinogen binding protein HBS1_N PF08938.5 ESA04201.1 - 0.12 12.5 0.6 1.5 9.0 0.4 2.2 1 1 0 1 1 1 0 HBS1 N-terminus Phage_Gp14 PF10666.4 ESA04201.1 - 0.19 11.5 1.7 10 5.9 0.2 2.3 1 1 2 3 3 3 0 Phage protein Gp14 BTB PF00651.26 ESA04203.1 - 5.2e-19 68.2 0.1 6e-19 68.0 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA04203.1 - 0.088 11.9 0.1 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) XLF PF09302.6 ESA04204.1 - 0.082 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 XLF (XRCC4-like factor) HTH_21 PF13276.1 ESA04205.1 - 0.046 13.7 0.2 0.083 12.9 0.1 1.4 1 0 0 1 1 1 0 HTH-like domain DUF1878 PF08963.5 ESA04205.1 - 0.18 12.0 1.9 0.36 11.0 1.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1878) IMS_HHH PF11798.3 ESA04209.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 IMS family HHH motif GP41 PF00517.12 ESA04210.1 - 0.00073 19.1 0.0 0.00087 18.9 0.0 1.1 1 0 0 1 1 1 1 Retroviral envelope protein Leu_zip PF15294.1 ESA04210.1 - 0.0041 16.2 0.3 0.0046 16.0 0.2 1.0 1 0 0 1 1 1 1 Leucine zipper RBD PF02196.10 ESA04210.1 - 0.0042 16.7 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Raf-like Ras-binding domain IncA PF04156.9 ESA04210.1 - 0.024 14.2 0.3 0.027 14.0 0.2 1.1 1 0 0 1 1 1 0 IncA protein CCDC155 PF14662.1 ESA04210.1 - 0.032 13.8 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 BLOC1_2 PF10046.4 ESA04210.1 - 0.04 14.0 0.4 0.063 13.4 0.3 1.3 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Striatin PF08232.7 ESA04210.1 - 0.041 14.1 0.1 0.045 14.0 0.1 1.1 1 0 0 1 1 1 0 Striatin family Tmemb_cc2 PF10267.4 ESA04210.1 - 0.059 11.9 0.0 0.069 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Laminin_II PF06009.7 ESA04210.1 - 0.067 12.9 0.1 0.088 12.5 0.1 1.1 1 0 0 1 1 1 0 Laminin Domain II Oxidored_nitro PF00148.14 ESA04210.1 - 0.069 11.7 0.0 0.074 11.6 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Apolipoprotein PF01442.13 ESA04210.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain RESP18 PF14948.1 ESA04214.1 - 0.016 15.2 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 RESP18 domain DUF2481 PF10654.4 ESA04215.1 - 0.018 14.7 1.8 0.022 14.4 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) Ku_PK_bind PF08785.6 ESA04215.1 - 0.11 12.4 0.5 0.12 12.2 0.4 1.1 1 0 0 1 1 1 0 Ku C terminal domain like LINES_N PF14694.1 ESA04216.1 - 1.9e-11 43.8 8.9 1.9e-11 43.8 6.2 2.1 2 2 0 2 2 2 1 Lines N-terminus Bac_rhodopsin PF01036.13 ESA04218.1 - 0.045 13.0 0.4 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Bacteriorhodopsin-like protein Pkinase_Tyr PF07714.12 ESA04218.1 - 0.046 12.7 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase MreB_Mbl PF06723.8 ESA04219.1 - 0.0076 14.8 0.0 0.04 12.4 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein DUF3684 PF12449.3 ESA04220.1 - 5.7e-08 30.8 0.2 1.1e-05 23.2 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA04220.1 - 1.8e-05 24.3 0.0 3.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA04220.1 - 0.0057 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RecX PF02631.11 ESA04222.1 - 0.0027 17.8 0.0 0.0056 16.8 0.0 1.6 1 0 0 1 1 1 1 RecX family DUF1551 PF07585.6 ESA04222.1 - 0.16 10.7 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1551) AAA_17 PF13207.1 ESA04222.1 - 1.9 9.3 4.1 8.9 7.1 0.0 3.4 3 2 0 3 3 3 0 AAA domain Phage_integrase PF00589.17 ESA04225.1 - 1.8e-07 30.9 0.1 2.5e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family HMG_box_2 PF09011.5 ESA04227.1 - 0.026 14.8 1.3 0.051 13.9 0.9 1.4 1 0 0 1 1 1 0 HMG-box domain HMG_box PF00505.14 ESA04227.1 - 0.082 13.1 1.4 0.15 12.3 1.0 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box UL40 PF10682.4 ESA04228.1 - 0.046 13.2 0.0 0.052 13.0 0.0 1.1 1 0 0 1 1 1 0 Glycoprotein of human cytomegalovirus HHV-5 PAP_RNA-bind PF04926.10 ESA04229.1 - 0.22 11.0 2.1 0.36 10.3 1.5 1.3 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain TLD PF07534.11 ESA04230.1 - 2.9e-12 46.7 2.2 3.3e-12 46.5 0.7 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04230.1 - 7.3e-05 22.5 4.1 0.0045 16.7 0.5 2.6 1 1 1 2 2 2 2 BTB And C-terminal Kelch 120_Rick_ant PF12574.3 ESA04230.1 - 0.11 11.6 0.2 0.24 10.4 0.1 1.5 1 1 0 1 1 1 0 120 KDa Rickettsia surface antigen RasGEF_N PF00618.15 ESA04230.1 - 0.45 10.6 3.1 0.31 11.1 0.2 2.2 2 1 0 2 2 2 0 RasGEF N-terminal motif Pkinase_Tyr PF07714.12 ESA04232.1 - 9.1e-30 103.5 0.0 1.3e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04232.1 - 1.2e-29 103.3 0.0 1.7e-29 102.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA04232.1 - 0.016 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA04232.1 - 0.056 13.1 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA04233.1 - 5.7e-06 25.5 0.0 1.2e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Recep_L_domain PF01030.19 ESA04233.1 - 0.079 12.9 1.9 0.13 12.2 1.3 1.4 1 1 0 1 1 1 0 Receptor L domain DUF465 PF04325.8 ESA04236.1 - 0.07 12.8 0.3 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF465) Kinesin PF00225.18 ESA04237.1 - 2.2e-67 227.1 1.4 4.4e-67 226.1 0.9 1.5 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA04237.1 - 0.043 12.7 0.1 0.072 11.9 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein BTB PF00651.26 ESA04239.1 - 6.4e-11 42.2 0.0 1.3e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04239.1 - 1.7e-10 41.0 2.1 1.7e-10 41.0 1.5 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04239.1 - 6.7e-06 25.8 0.2 2.6e-05 24.0 0.1 2.1 1 1 0 1 1 1 1 BTB And C-terminal Kelch Myb_DNA-bind_4 PF13837.1 ESA04241.1 - 0.073 13.2 0.2 0.14 12.3 0.1 1.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain EVI2A PF05399.6 ESA04242.1 - 0.0067 15.7 0.1 0.0067 15.7 0.0 2.7 2 1 1 3 3 3 1 Ectropic viral integration site 2A protein (EVI2A) Phage_integrase PF00589.17 ESA04243.1 - 0.00036 20.2 0.0 0.00059 19.5 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family DUF3435 PF11917.3 ESA04243.1 - 0.04 12.6 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DUF3835 PF12927.2 ESA04243.1 - 0.22 12.4 3.4 0.3 12.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) PPR_2 PF13041.1 ESA04245.1 - 3.2e-53 177.4 11.1 8.9e-14 51.2 0.1 7.2 2 2 5 7 7 7 7 PPR repeat family PPR PF01535.15 ESA04245.1 - 1.8e-37 124.6 13.6 2.7e-07 30.1 0.1 7.6 8 0 0 8 8 8 6 PPR repeat PPR_3 PF13812.1 ESA04245.1 - 2.2e-37 124.1 0.1 1.9e-06 27.6 0.0 8.2 8 0 0 8 8 8 6 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA04245.1 - 1.6e-29 101.0 6.5 1.4e-08 34.0 0.0 7.4 8 0 0 8 8 8 4 PPR repeat RPM2 PF08579.6 ESA04245.1 - 5.3e-05 23.3 2.6 0.04 14.0 0.5 4.0 2 1 2 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ATP13 PF12921.2 ESA04245.1 - 0.0023 17.2 0.1 4.2 6.7 0.0 3.4 3 1 1 4 4 4 1 Mitochondrial ATPase expression TPR_1 PF00515.23 ESA04245.1 - 0.0055 16.2 0.4 0.6 9.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Rep_fac_C PF08542.6 ESA04245.1 - 0.0055 16.6 0.2 4.3 7.3 0.0 3.6 3 2 0 3 3 3 1 Replication factor C C-terminal domain TPR_14 PF13428.1 ESA04245.1 - 0.01 16.3 0.0 10 7.0 0.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA04245.1 - 0.015 15.2 0.3 25 5.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA04245.1 - 0.025 14.3 0.0 12 5.9 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TLD PF07534.11 ESA04246.1 - 0.0047 16.9 1.9 0.0098 15.8 1.3 1.6 1 1 0 1 1 1 1 TLD DUF3579 PF12112.3 ESA04247.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3579) Y_Y_Y PF07495.8 ESA04249.1 - 0.021 14.5 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain F-box-like PF12937.2 ESA04253.1 - 0.00062 19.4 0.6 0.0022 17.6 0.4 1.9 1 0 0 1 1 1 1 F-box-like DUF1132 PF06575.7 ESA04254.1 - 0.14 12.4 4.4 0.23 11.7 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1132) Gemin6 PF06372.7 ESA04255.1 - 0.017 14.4 0.0 0.019 14.2 0.0 1.0 1 0 0 1 1 1 0 Gemin6 protein LRR_4 PF12799.2 ESA04257.1 - 0.12 12.0 1.8 0.18 11.4 1.2 1.4 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Myb_DNA-bind_4 PF13837.1 ESA04261.1 - 2.7e-06 27.4 0.4 2.7e-06 27.4 0.3 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA04261.1 - 0.027 15.1 0.2 0.043 14.4 0.1 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain BTB PF00651.26 ESA04262.1 - 1.6e-18 66.7 0.0 2.7e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04262.1 - 2.5e-10 40.0 5.1 4.3e-06 26.4 0.3 4.2 3 1 1 4 4 4 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA04262.1 - 0.061 13.4 0.1 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain NUMOD1 PF07453.8 ESA04263.1 - 9.3e-05 22.1 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 NUMOD1 domain DUF2976 PF11190.3 ESA04264.1 - 6.2e-05 22.4 0.2 8.5e-05 22.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2976) COPI_assoc PF08507.5 ESA04264.1 - 0.069 12.8 0.1 0.085 12.5 0.1 1.1 1 0 0 1 1 1 0 COPI associated protein Chordopox_A15 PF05846.7 ESA04265.1 - 0.088 12.8 0.2 5 7.2 0.0 2.7 2 0 0 2 2 2 0 Chordopoxvirus A15 protein DUF1987 PF09345.5 ESA04268.1 - 0.84 9.4 4.8 0.37 10.6 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1987) Prenyltrans PF00432.16 ESA04269.1 - 1.4e-30 104.4 6.8 3.5e-10 39.2 0.1 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESA04269.1 - 7.3e-27 94.0 4.0 4.5e-14 52.8 0.3 5.0 3 2 2 5 5 5 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESA04269.1 - 3.1e-24 85.0 2.3 8.3e-15 54.7 0.1 5.6 3 3 3 6 6 6 6 Prenyltransferase-like Pec_lyase PF09492.5 ESA04269.1 - 5.6e-07 29.0 3.7 0.073 12.2 0.0 5.6 2 1 3 6 6 6 2 Pectic acid lyase A2M_comp PF07678.9 ESA04269.1 - 9e-05 21.8 0.4 0.047 12.9 0.0 3.6 2 1 1 3 3 3 1 A-macroglobulin complement component Mago-bind PF09282.5 ESA04269.1 - 0.0059 16.1 0.0 0.074 12.6 0.0 2.5 2 0 0 2 2 2 1 Mago binding Olfactory_mark PF06554.7 ESA04270.1 - 0.11 12.0 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 Olfactory marker protein Vma12 PF11712.3 ESA04270.1 - 0.12 12.0 3.5 0.12 12.1 1.3 1.6 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SPRY PF00622.23 ESA04271.1 - 3e-22 79.0 0.3 4e-22 78.6 0.2 1.2 1 0 0 1 1 1 1 SPRY domain PB1 PF00564.19 ESA04272.1 - 0.012 15.2 0.1 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 PB1 domain FAM60A PF15396.1 ESA04272.1 - 0.12 12.1 4.3 0.16 11.6 3.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Mid2 PF04478.7 ESA04275.1 - 0.071 12.5 1.2 0.11 11.9 0.1 1.8 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Hyd_WA PF06462.7 ESA04275.1 - 0.6 9.7 2.8 2.5 7.7 0.0 3.0 3 0 0 3 3 3 0 Propeller Drf_FH3 PF06367.11 ESA04278.1 - 3e-28 98.5 1.9 4.9e-28 97.8 1.3 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_GBD PF06371.8 ESA04278.1 - 5.4e-05 22.6 0.3 5.4e-05 22.6 0.2 2.3 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain DBR1 PF05011.8 ESA04278.1 - 0.015 15.1 0.2 0.038 13.8 0.2 1.7 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain DUF445 PF04286.7 ESA04278.1 - 0.042 13.3 2.4 0.061 12.8 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF605 PF04652.11 ESA04278.1 - 0.066 12.5 11.2 0.081 12.3 7.7 1.2 1 0 0 1 1 1 0 Vta1 like Ribosomal_S17 PF00366.15 ESA04279.1 - 0.034 14.2 0.1 0.087 12.8 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein S17 Sel1 PF08238.7 ESA04283.1 - 4.9e-23 81.0 3.5 2.3e-12 47.1 0.2 2.1 2 0 0 2 2 2 2 Sel1 repeat TPR_20 PF14561.1 ESA04283.1 - 0.0027 17.7 0.0 0.26 11.4 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat MIT PF04212.13 ESA04283.1 - 0.0046 16.7 0.3 0.13 12.1 0.0 2.4 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain DUF2989 PF11207.3 ESA04283.1 - 0.013 15.0 0.2 0.015 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) TPR_17 PF13431.1 ESA04283.1 - 0.017 15.2 2.8 2.1 8.7 0.4 3.1 1 1 3 4 4 4 0 Tetratricopeptide repeat NlpE PF04170.7 ESA04283.1 - 0.043 14.2 2.3 1.6 9.1 0.1 2.0 1 1 1 2 2 2 0 NlpE N-terminal domain TPR_2 PF07719.12 ESA04283.1 - 0.089 12.7 8.3 5.8 7.0 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3674 PF12426.3 ESA04283.1 - 0.16 11.4 0.4 0.94 8.9 0.0 2.2 2 1 0 2 2 2 0 RNA dependent RNA polymerase TPR_6 PF13174.1 ESA04283.1 - 0.17 12.4 0.5 11 6.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA04283.1 - 0.31 10.7 9.2 7.7 6.3 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA04284.1 - 1.7e-121 393.9 84.8 2.1e-11 44.0 1.6 12.8 12 1 1 13 13 13 12 Sel1 repeat MIT PF04212.13 ESA04284.1 - 6e-11 42.0 46.7 0.19 11.6 0.2 10.5 10 1 0 10 10 10 6 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA04284.1 - 6.1e-11 42.0 43.2 0.36 11.3 0.2 11.3 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESA04284.1 - 8.5e-06 25.6 56.1 0.037 13.9 4.2 9.2 2 2 8 10 10 10 6 Tetratricopeptide repeat TPR_20 PF14561.1 ESA04284.1 - 4.5e-05 23.4 14.0 2.1 8.5 0.4 6.7 3 3 5 8 8 8 2 Tetratricopeptide repeat Pneumovirus_M2 PF06436.6 ESA04284.1 - 0.0057 15.9 1.8 4.4 6.5 0.1 3.5 3 1 1 4 4 4 2 Pneumovirus matrix protein 2 (M2) Peptidase_C14 PF00656.17 ESA04284.1 - 0.0063 16.2 0.4 6.7 6.3 0.0 4.4 1 1 1 3 3 3 1 Caspase domain Flu_M1_C PF08289.6 ESA04284.1 - 0.0085 16.0 0.1 45 4.1 0.0 5.3 2 2 4 7 7 7 0 Influenza Matrix protein (M1) C-terminal domain TPR_17 PF13431.1 ESA04284.1 - 0.62 10.4 47.2 6.4 7.2 0.7 11.5 11 1 0 11 11 11 0 Tetratricopeptide repeat HTH_16 PF12645.2 ESA04284.1 - 1.2 9.1 10.7 52 3.8 0.1 6.1 6 1 1 7 7 7 0 Helix-turn-helix domain DUF3733 PF12534.3 ESA04284.1 - 3.3 7.0 18.3 15 4.9 0.1 6.4 6 1 1 7 7 7 0 Leucine-rich repeat containing protein 8 VirC1 PF07015.6 ESA04285.1 - 0.075 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein DUF1797 PF08796.5 ESA04286.1 - 0.019 14.8 0.3 0.025 14.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) DUF3810 PF12725.2 ESA04289.1 - 0.013 14.4 3.3 0.019 13.8 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Vfa1 PF08432.5 ESA04289.1 - 8 6.4 22.1 1.4 8.8 7.3 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF3391 PF11871.3 ESA04290.1 - 0.12 12.5 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Cactin_mid PF10312.4 ESA04293.1 - 0.0018 17.5 1.8 0.0018 17.5 1.2 1.6 1 1 0 1 1 1 1 Conserved mid region of cactin MbeB_N PF04837.7 ESA04293.1 - 0.099 12.7 0.4 0.099 12.7 0.3 2.1 2 0 0 2 2 2 0 MbeB-like, N-term conserved region ITI_HC_C PF06668.7 ESA04294.1 - 0.088 12.2 0.1 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Inter-alpha-trypsin inhibitor heavy chain C-terminus DUF1542 PF07564.6 ESA04295.1 - 0.04 13.9 1.2 0.095 12.7 0.2 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF1539 PF07560.6 ESA04295.1 - 0.064 13.1 0.0 0.1 12.4 0.0 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) Fib_alpha PF08702.5 ESA04296.1 - 0.079 13.0 0.2 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family YgbB PF02542.11 ESA04297.1 - 0.051 13.3 0.1 0.066 13.0 0.1 1.3 1 0 0 1 1 1 0 YgbB family E2_bind PF08825.5 ESA04297.1 - 0.077 12.7 0.1 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 E2 binding domain UDPGT PF00201.13 ESA04298.1 - 1.2e-21 76.9 0.0 1.9e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA04298.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA04298.1 - 8.9e-06 25.1 0.0 7.5e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 1 DUF4411 PF14367.1 ESA04299.1 - 0.042 13.5 0.3 0.074 12.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) DUF2829 PF11195.3 ESA04299.1 - 0.043 14.3 0.3 0.043 14.3 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2829) Oscp1 PF10188.4 ESA04299.1 - 0.11 12.3 0.5 0.25 11.1 0.3 1.6 1 0 0 1 1 1 0 Organic solute transport protein 1 DUF4468 PF14730.1 ESA04300.1 - 0.022 14.4 0.3 0.033 13.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold DUF1247 PF06851.6 ESA04300.1 - 0.09 12.4 0.1 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) HTH_28 PF13518.1 ESA04301.1 - 4.3e-08 33.0 0.0 6.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA04301.1 - 7.3e-07 28.6 0.0 1.2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA04301.1 - 1e-06 28.8 0.1 1e-06 28.8 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 ESA04301.1 - 1.1e-05 25.1 0.1 1.1e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.1 ESA04301.1 - 0.00016 22.4 1.0 0.00022 21.9 0.7 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 ESA04301.1 - 0.00052 19.3 0.1 0.002 17.4 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Tnp_4 PF13613.1 ESA04301.1 - 0.028 13.9 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease CENP-B_N PF04218.8 ESA04301.1 - 0.058 12.8 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain MerR_1 PF13411.1 ESA04301.1 - 0.095 12.4 0.4 0.14 11.9 0.2 1.4 1 1 0 1 1 1 0 MerR HTH family regulatory protein TrmB PF01978.14 ESA04301.1 - 0.12 12.0 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB zf-CCHC PF00098.18 ESA04302.1 - 5.3e-07 29.2 0.4 8.9e-07 28.5 0.3 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 ESA04302.1 - 0.00057 19.9 0.9 0.0035 17.3 0.0 2.7 2 0 0 2 2 2 1 Retrotransposon gag protein PAS PF00989.19 ESA04303.1 - 2e-05 24.3 0.0 5.5e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 ESA04303.1 - 0.0015 18.3 10.6 0.0015 18.3 7.4 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YtfJ_HI0045 PF09695.5 ESA04303.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) FNIP_C PF14638.1 ESA04304.1 - 9e-24 83.8 0.5 3.5e-23 81.9 0.0 2.2 2 0 0 2 2 2 1 Folliculin-interacting protein C-terminus FNIP_M PF14637.1 ESA04304.1 - 5.7e-16 58.8 6.5 1.9e-08 34.1 0.1 3.2 3 0 0 3 3 3 2 Folliculin-interacting protein middle domain FNIP_N PF14636.1 ESA04304.1 - 3.5e-15 56.6 0.6 3.5e-15 56.6 0.4 2.9 3 0 0 3 3 3 1 Folliculin-interacting protein N-terminus Homeobox PF00046.24 ESA04305.1 - 7.2e-18 63.9 4.9 1.5e-17 62.9 3.4 1.6 1 0 0 1 1 1 1 Homeobox domain MRP-L20 PF12824.2 ESA04305.1 - 0.011 15.7 0.4 0.017 15.1 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 HTH_11 PF08279.7 ESA04305.1 - 0.022 14.4 0.1 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 HTH domain RNA_lig_T4_1 PF09511.5 ESA04305.1 - 0.038 13.4 0.9 0.075 12.4 0.6 1.6 1 1 0 1 1 1 0 RNA ligase Homeobox_KN PF05920.6 ESA04305.1 - 0.11 12.2 0.5 0.11 12.2 0.4 2.4 3 0 0 3 3 3 0 Homeobox KN domain DEAD PF00270.24 ESA04306.1 - 7.1e-49 165.5 0.0 4e-47 159.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA04306.1 - 9.6e-11 41.3 0.0 2.4e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA04306.1 - 0.00014 21.7 0.0 0.00052 19.9 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESA04306.1 - 0.038 13.7 0.0 3.2 7.5 0.0 2.5 2 1 0 2 2 2 0 Part of AAA domain Glyoxalase_3 PF13468.1 ESA04306.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain Helicase_C_2 PF13307.1 ESA04306.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain DUF2443 PF10398.4 ESA04306.1 - 0.13 12.0 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) AAA_22 PF13401.1 ESA04306.1 - 0.15 12.2 1.9 2.7 8.1 0.5 2.9 1 1 1 2 2 2 0 AAA domain DUF2722 PF10846.3 ESA04308.1 - 0.1 11.6 5.8 0.14 11.1 3.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) SNF2_N PF00176.18 ESA04309.1 - 9.6e-74 247.8 0.1 1.7e-73 247.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 ESA04309.1 - 3.2e-24 84.3 1.7 3.4e-11 42.6 0.0 3.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 ESA04309.1 - 5.5e-18 64.5 0.0 1.9e-17 62.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Myb_DNA-binding PF00249.26 ESA04309.1 - 0.0011 18.9 0.0 0.0043 17.0 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Macoilin PF09726.4 ESA04309.1 - 0.29 9.3 20.3 0.46 8.6 14.0 1.2 1 0 0 1 1 1 0 Transmembrane protein Pkinase_Tyr PF07714.12 ESA04311.1 - 0.0034 16.4 0.0 0.0035 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA04315.1 - 2.3e-33 115.3 0.0 2.9e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04315.1 - 2.2e-27 95.8 0.1 2.8e-27 95.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA04315.1 - 4.6e-06 25.7 0.0 8.5e-06 24.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA04315.1 - 0.011 14.8 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Exo_endo_phos PF03372.18 ESA04317.1 - 0.0043 17.0 0.0 0.0053 16.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.20 ESA04319.1 - 3.9e-53 180.2 0.0 9.6e-53 178.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04319.1 - 7.7e-37 126.7 0.0 1.4e-36 125.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA04319.1 - 0.0074 15.2 0.0 0.023 13.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like HEAT PF02985.17 ESA04319.1 - 0.073 13.1 0.1 6.5 7.1 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat zf-CCHC PF00098.18 ESA04321.1 - 0.0017 18.1 2.4 0.0031 17.3 1.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.1 ESA04321.1 - 0.0045 16.6 2.6 0.0083 15.7 1.8 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 ESA04321.1 - 0.016 14.8 1.2 0.04 13.5 0.8 1.7 1 0 0 1 1 1 0 Zinc knuckle DUF2807 PF10988.3 ESA04321.1 - 0.03 13.8 0.4 0.048 13.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2807) Transket_pyr PF02779.19 ESA04323.1 - 1.1e-62 210.6 0.0 1.7e-62 210.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESA04323.1 - 1.3e-61 207.9 0.0 1.6e-61 207.6 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF485 PF04341.7 ESA04324.1 - 0.042 13.5 4.5 0.066 12.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF4191 PF13829.1 ESA04324.1 - 0.056 12.5 0.4 0.063 12.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) OppC_N PF12911.2 ESA04324.1 - 0.7 9.3 6.1 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Apq12 PF12716.2 ESA04324.1 - 2 8.2 16.6 2.8 7.7 11.5 1.2 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis Renin_r PF07850.9 ESA04324.1 - 3.6 7.9 5.1 15 6.0 3.5 1.9 1 1 0 1 1 1 0 Renin receptor-like protein MM_CoA_mutase PF01642.17 ESA04325.1 - 1e-250 832.2 0.1 1.2e-250 832.0 0.1 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.14 ESA04325.1 - 5.1e-15 55.4 0.1 1.3e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 B12 binding domain DUF3461 PF11944.3 ESA04325.1 - 0.031 14.1 0.0 0.081 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) AAT PF03417.11 ESA04325.1 - 0.059 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase PhnI PF05861.7 ESA04325.1 - 0.065 11.7 0.0 0.11 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnI) Transket_pyr PF02779.19 ESA04326.1 - 1e-63 214.0 0.0 1.7e-63 213.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESA04326.1 - 4.4e-56 189.8 0.0 8.3e-56 188.8 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component OTU PF02338.14 ESA04326.1 - 3.2e-18 66.4 1.1 1.3e-17 64.5 0.2 2.6 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 ESA04326.1 - 0.00049 19.5 2.1 0.54 9.5 0.1 2.8 1 1 0 2 2 2 2 Peptidase C65 Otubain Ras PF00071.17 ESA04327.1 - 1.9e-58 196.4 0.2 2.3e-58 196.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA04327.1 - 3.6e-19 69.4 0.0 5.1e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA04327.1 - 5.4e-09 35.5 0.0 6.7e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA04327.1 - 4.9e-07 29.3 0.1 9.9e-07 28.3 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA04327.1 - 0.0031 17.4 0.0 0.0037 17.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA04327.1 - 0.013 14.7 0.1 0.024 13.9 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.12 ESA04327.1 - 0.087 12.3 1.8 0.84 9.1 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.15 ESA04327.1 - 0.15 10.7 0.7 3.8 6.0 0.2 2.1 1 1 1 2 2 2 0 G-protein alpha subunit IstB_IS21 PF01695.12 ESA04327.1 - 0.23 10.8 0.7 1.5 8.2 0.1 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein Linker_histone PF00538.14 ESA04328.1 - 1.3e-24 86.1 0.1 2.7e-24 85.0 0.1 1.6 1 0 0 1 1 1 1 linker histone H1 and H5 family DUF126 PF01989.11 ESA04328.1 - 0.036 13.7 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF126 Endostatin PF06482.6 ESA04328.1 - 0.12 11.7 4.4 0.13 11.5 3.0 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Mucin PF01456.12 ESA04328.1 - 3.2 7.5 16.2 3.9 7.2 11.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MIP-T3 PF10243.4 ESA04328.1 - 3.8 5.8 30.7 5.7 5.2 21.3 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF4551 PF15087.1 ESA04328.1 - 6.9 4.8 9.6 6.8 4.9 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DnaG_DnaB_bind PF08278.6 ESA04329.1 - 0.03 14.5 0.9 1 9.6 0.0 2.9 2 1 1 3 3 3 0 DNA primase DnaG DnaB-binding Syntaxin_2 PF14523.1 ESA04329.1 - 0.28 11.2 7.7 0.6 10.1 1.0 2.6 2 0 0 2 2 2 0 Syntaxin-like protein Dak1 PF02733.12 ESA04330.1 - 1.1e-118 395.5 0.2 2e-118 394.6 0.1 1.4 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 ESA04330.1 - 2.9e-37 127.9 0.0 5.5e-37 127.1 0.0 1.5 1 0 0 1 1 1 1 DAK2 domain Cnl2_NKP2 PF09447.5 ESA04331.1 - 2.9e-14 52.5 1.7 3.8e-14 52.1 0.5 1.7 2 0 0 2 2 2 1 Cnl2/NKP2 family protein NTR2 PF15458.1 ESA04331.1 - 0.017 14.3 1.9 0.023 13.9 1.1 1.4 1 1 0 1 1 1 0 Nineteen complex-related protein 2 RNA_pol_Rpb1_6 PF04992.9 ESA04331.1 - 0.3 10.8 2.8 1 9.0 1.6 1.8 1 1 1 2 2 2 0 RNA polymerase Rpb1, domain 6 HsdM_N PF12161.3 ESA04331.1 - 0.61 10.5 4.7 3.7 7.9 2.9 2.2 1 1 0 1 1 1 0 HsdM N-terminal domain DUF3211 PF11485.3 ESA04333.1 - 0.0072 16.3 0.1 0.0075 16.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3211) Sel1 PF08238.7 ESA04334.1 - 7.6e-12 45.4 4.2 3.1e-07 30.8 0.0 3.0 2 1 1 3 3 3 2 Sel1 repeat TPR_19 PF14559.1 ESA04334.1 - 0.072 13.4 2.2 0.71 10.2 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA04334.1 - 0.22 12.2 2.4 1.3 9.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA04334.1 - 0.4 11.2 2.3 26 5.5 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA04334.1 - 2.6 7.7 7.1 67 3.2 0.4 2.9 2 1 0 2 2 2 0 TPR repeat Pkinase_Tyr PF07714.12 ESA04335.1 - 2.7e-20 72.5 0.1 2.9e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04335.1 - 2.9e-18 65.9 0.0 3.3e-18 65.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain AAA_14 PF13173.1 ESA04336.1 - 5e-06 26.4 3.4 1.1e-05 25.3 2.2 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA04336.1 - 4.6e-05 22.6 0.4 0.00099 18.2 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin ArgK PF03308.11 ESA04336.1 - 0.00035 19.4 0.9 0.002 16.9 0.0 2.1 2 0 0 2 2 2 1 ArgK protein KTI12 PF08433.5 ESA04336.1 - 0.001 18.3 0.2 0.0018 17.5 0.1 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 cobW PF02492.14 ESA04336.1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Thymidylate_kin PF02223.12 ESA04336.1 - 0.0013 18.0 3.1 0.014 14.7 2.1 2.7 1 1 0 1 1 1 1 Thymidylate kinase AAA_16 PF13191.1 ESA04336.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA04336.1 - 0.0016 18.6 0.1 0.017 15.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESA04336.1 - 0.0017 18.1 12.0 0.02 14.5 8.3 2.2 1 1 0 1 1 1 1 Archaeal ATPase AAA_17 PF13207.1 ESA04336.1 - 0.0021 18.8 0.4 0.0021 18.8 0.3 2.3 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA04336.1 - 0.0059 15.8 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 DUF815 PF05673.8 ESA04336.1 - 0.0081 15.1 0.3 0.65 8.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.10 ESA04336.1 - 0.012 15.3 0.2 0.051 13.2 0.1 2.2 1 1 0 1 1 1 0 NTPase TrwB_AAD_bind PF10412.4 ESA04336.1 - 0.013 14.1 0.0 0.026 13.1 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.1 ESA04336.1 - 0.014 15.3 0.0 0.026 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESA04336.1 - 0.017 15.4 0.2 0.017 15.4 0.1 3.0 1 1 1 3 3 3 0 AAA domain NACHT PF05729.7 ESA04336.1 - 0.026 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 ESA04336.1 - 0.031 14.4 0.7 0.29 11.3 0.0 2.4 1 1 0 2 2 2 0 RNA helicase MobB PF03205.9 ESA04336.1 - 0.036 13.7 1.6 0.047 13.4 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ESA04336.1 - 0.066 13.0 0.1 0.36 10.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESA04336.1 - 0.069 13.4 0.3 0.13 12.5 0.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA_19 PF13245.1 ESA04336.1 - 0.081 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 ESA04336.1 - 0.11 11.3 0.1 0.24 10.2 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Viral_helicase1 PF01443.13 ESA04336.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF87 PF01935.12 ESA04336.1 - 5.2 6.8 8.4 1.3 8.8 0.1 3.0 2 2 1 3 3 3 0 Domain of unknown function DUF87 PNPOx_C PF10590.4 ESA04337.1 - 0.043 13.3 0.0 0.08 12.4 0.0 1.5 2 0 0 2 2 2 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Cation_ATPase_C PF00689.16 ESA04339.1 - 2.6e-18 66.2 2.8 3.4e-18 65.7 2.0 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus BTB PF00651.26 ESA04340.1 - 1.3e-18 66.9 0.2 2.4e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04340.1 - 9.2e-07 28.6 10.0 1.5e-05 24.7 0.1 4.4 5 1 1 6 6 6 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA04340.1 - 0.0095 15.1 0.6 0.013 14.6 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Bcl-2 PF00452.14 ESA04340.1 - 0.032 14.3 0.0 0.085 12.9 0.0 1.8 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Urm1 PF09138.6 ESA04340.1 - 0.042 13.9 0.8 0.18 11.9 0.1 2.2 1 1 0 2 2 2 0 Urm1 (Ubiquitin related modifier) BTB PF00651.26 ESA04341.1 - 6.9e-17 61.4 0.1 1.4e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04341.1 - 9.8e-10 38.2 5.0 1.2e-06 28.3 0.9 3.4 1 1 2 3 3 3 2 BTB And C-terminal Kelch DUF3579 PF12112.3 ESA04341.1 - 0.11 12.4 0.1 0.88 9.5 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3579) Pkinase_Tyr PF07714.12 ESA04342.1 - 6.3e-26 90.9 0.1 7.7e-26 90.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04342.1 - 8.7e-23 80.7 0.3 1e-22 80.5 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA04342.1 - 1.3e-05 24.2 0.0 1.5e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA04342.1 - 0.0042 16.1 0.1 0.005 15.9 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA04342.1 - 0.077 12.3 0.3 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 RIO1 family Sel1 PF08238.7 ESA04343.1 - 6e-40 134.7 16.1 1.6e-09 38.0 0.1 5.0 5 0 0 5 5 5 4 Sel1 repeat MIT PF04212.13 ESA04343.1 - 0.0066 16.3 12.1 0.42 10.5 2.2 4.1 2 2 1 3 3 3 3 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA04343.1 - 0.0072 15.9 15.7 0.039 13.6 1.7 4.4 1 1 3 4 4 4 3 TPR repeat AdoMet_MTase PF07757.8 ESA04343.1 - 0.014 15.4 0.8 9.8 6.3 0.0 3.0 1 1 2 3 3 3 0 Predicted AdoMet-dependent methyltransferase DUF4500 PF14937.1 ESA04343.1 - 0.022 14.5 0.1 0.41 10.4 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4500) DUF1643 PF07799.7 ESA04344.1 - 0.01 15.5 0.1 1.3 8.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) GCFC PF07842.7 ESA04344.1 - 0.076 12.3 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein GCFC PF07842.7 ESA04345.1 - 0.0073 15.7 0.1 0.019 14.3 0.0 1.6 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein GalP_UDP_transf PF01087.17 ESA04346.1 - 0.054 13.5 0.4 0.2 11.7 0.1 1.8 2 0 0 2 2 2 0 Galactose-1-phosphate uridyl transferase, N-terminal domain Y_phosphatase3 PF13350.1 ESA04346.1 - 0.067 13.4 0.0 0.098 12.9 0.0 1.3 1 1 0 1 1 1 0 Tyrosine phosphatase family RNA_pol_A_CTD PF03118.10 ESA04346.1 - 0.087 12.2 0.5 5.5 6.4 0.1 2.7 2 1 1 3 3 3 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF3584 PF12128.3 ESA04346.1 - 0.23 8.7 1.7 0.28 8.4 1.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4618 PF15397.1 ESA04346.1 - 0.23 10.7 4.5 0.41 9.9 1.6 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) BCAS2 PF05700.6 ESA04346.1 - 0.25 10.7 2.6 1.4 8.3 0.4 2.1 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Syntaxin_2 PF14523.1 ESA04346.1 - 0.33 10.9 4.8 0.067 13.2 0.8 1.7 2 0 0 2 2 2 0 Syntaxin-like protein Prefoldin_2 PF01920.15 ESA04346.1 - 0.68 9.7 4.8 10 5.9 3.3 2.2 1 1 0 1 1 1 0 Prefoldin subunit PP2C PF00481.16 ESA04349.1 - 5.4e-37 127.5 0.1 6.1e-36 124.1 0.1 2.3 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESA04349.1 - 5e-09 35.8 0.0 1.9e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 ESA04349.1 - 0.0084 15.8 0.0 0.94 9.1 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) TFIID_90kDa PF04494.10 ESA04350.1 - 0.038 14.0 0.4 0.077 13.0 0.2 1.5 1 1 0 1 1 1 0 WD40 associated region in TFIID subunit HTH_Tnp_IS1 PF12759.2 ESA04351.1 - 0.051 13.0 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 InsA C-terminal domain DUF3040 PF11239.3 ESA04352.1 - 0.01 15.8 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) UDPGT PF00201.13 ESA04352.1 - 0.089 11.3 0.4 0.14 10.7 0.3 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase UDPGT PF00201.13 ESA04353.1 - 3.4e-07 29.1 0.0 2.4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.15 ESA04353.1 - 0.00077 19.2 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Thioredoxin_4 PF13462.1 ESA04354.1 - 0.05 13.6 0.1 0.063 13.2 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin FSIP1 PF15554.1 ESA04355.1 - 0.037 12.8 0.6 0.048 12.4 0.4 1.1 1 0 0 1 1 1 0 FSIP1 family SPRY PF00622.23 ESA04358.1 - 2.8e-07 30.6 0.2 4.4e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA04358.1 - 3.4e-05 23.7 1.7 0.00028 20.8 0.1 2.4 2 0 0 2 2 2 1 BTB/POZ domain CAGE1 PF15066.1 ESA04358.1 - 0.013 14.0 0.6 0.021 13.2 0.4 1.3 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family Enterotoxin_HS1 PF08090.6 ESA04358.1 - 0.033 13.9 0.5 0.033 13.9 0.4 1.9 2 0 0 2 2 2 0 Heat stable E.coli enterotoxin 1 Pkinase_Tyr PF07714.12 ESA04359.1 - 7.6e-32 110.3 0.0 8.9e-32 110.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04359.1 - 1.7e-24 86.3 0.0 2.1e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA04359.1 - 0.059 12.5 0.1 0.088 12.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA04361.1 - 6e-24 84.5 0.0 7.2e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04361.1 - 1.7e-21 76.5 0.0 2.2e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA04363.1 - 6.4e-25 87.7 0.0 1e-24 87.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04363.1 - 3.9e-14 52.3 0.0 7.1e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA04364.1 - 4.6e-87 284.5 29.6 1.1e-10 41.7 0.1 12.3 12 0 0 12 12 12 10 Sel1 repeat Pkinase_Tyr PF07714.12 ESA04364.1 - 3.8e-44 150.7 0.0 5.5e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04364.1 - 4.3e-43 147.3 0.0 7e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA04364.1 - 7.8e-06 25.3 0.1 1.8e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 RIO1 family TPR_6 PF13174.1 ESA04364.1 - 2.4e-05 24.4 12.9 3.2 8.4 0.0 8.6 9 0 0 9 9 9 1 Tetratricopeptide repeat APH PF01636.18 ESA04364.1 - 0.026 14.2 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Apc3 PF12895.2 ESA04364.1 - 0.03 14.4 0.8 0.03 14.4 0.5 5.4 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Kdo PF06293.9 ESA04364.1 - 0.036 13.1 0.1 0.096 11.7 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIT PF04212.13 ESA04364.1 - 0.06 13.2 13.9 1.3 8.9 0.3 5.7 5 2 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESA04364.1 - 1 10.1 4.4 19 6.1 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA04366.1 - 1e-242 779.3 117.1 2.9e-12 46.7 0.6 25.2 25 0 0 25 25 25 24 Sel1 repeat Pkinase PF00069.20 ESA04366.1 - 1.4e-44 152.2 0.1 2.4e-44 151.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04366.1 - 6.6e-44 149.9 0.0 1.1e-43 149.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_6 PF13174.1 ESA04366.1 - 5.2e-06 26.5 46.4 7.4 7.2 0.0 15.8 18 1 0 18 18 18 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA04366.1 - 0.0002 21.3 2.7 65 3.6 0.0 7.6 7 3 0 8 8 8 0 Influenza Matrix protein (M1) C-terminal domain RIO1 PF01163.17 ESA04366.1 - 0.0005 19.4 0.1 0.0014 18.0 0.1 1.7 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA04366.1 - 0.0092 15.0 0.1 0.021 13.8 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA04366.1 - 0.015 15.0 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family UPF0118 PF01594.11 ESA04366.1 - 0.98 8.3 2.1 1.5 7.7 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF20 Sel1 PF08238.7 ESA04367.1 - 2.4e-243 781.3 161.1 5.4e-12 45.9 1.3 29.1 29 0 0 29 29 29 29 Sel1 repeat Peptidase_C14 PF00656.17 ESA04367.1 - 8.1e-13 48.6 5.0 0.16 11.6 0.0 10.8 4 3 3 7 7 7 2 Caspase domain Flu_M1_C PF08289.6 ESA04367.1 - 1.3e-05 25.1 0.2 22 5.1 0.0 8.4 7 2 3 10 10 10 0 Influenza Matrix protein (M1) C-terminal domain TPR_20 PF14561.1 ESA04367.1 - 1.3e-05 25.2 28.8 3.2 7.9 0.1 12.3 9 2 4 14 14 14 1 Tetratricopeptide repeat HTH_16 PF12645.2 ESA04367.1 - 3.6e-05 23.6 59.9 3.2 7.7 0.1 18.0 21 0 0 21 21 21 3 Helix-turn-helix domain DUF1843 PF08898.5 ESA04367.1 - 0.00061 19.7 2.7 70 3.5 0.0 7.1 7 1 1 8 8 8 0 Domain of unknown function (DUF1843) DZR PF12773.2 ESA04367.1 - 0.019 14.7 2.3 0.055 13.3 1.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon DUF2530 PF10745.4 ESA04367.1 - 0.26 11.3 0.0 3.9e+02 1.1 0.0 6.3 11 0 0 11 11 11 0 Protein of unknown function (DUF2530) ESR1_C PF12743.2 ESA04367.1 - 0.64 9.5 11.5 11 5.7 0.0 7.2 7 0 0 7 7 7 0 Oestrogen-type nuclear receptor final C-terminal TPR_6 PF13174.1 ESA04367.1 - 1.2 9.7 51.8 0.24 11.9 0.2 13.5 14 0 0 14 14 14 0 Tetratricopeptide repeat hNIFK_binding PF12196.3 ESA04368.1 - 0.18 11.2 1.5 0.37 10.1 1.0 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK KIAA1430 PF13879.1 ESA04368.1 - 0.23 11.8 9.9 0.76 10.2 6.9 1.7 1 1 0 1 1 1 0 KIAA1430 homologue RNA_pol_Rpb2_6 PF00562.23 ESA04369.1 - 3e-123 411.3 0.3 6.8e-123 410.2 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESA04369.1 - 1.3e-51 174.3 1.0 1.3e-51 174.3 0.7 1.5 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 ESA04369.1 - 6.4e-31 106.4 0.4 1.8e-30 105.0 0.3 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.9 ESA04369.1 - 7e-29 100.5 4.0 1.7e-28 99.3 2.8 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.8 ESA04369.1 - 8.8e-24 83.1 0.3 2.2e-23 81.8 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 ESA04369.1 - 2.6e-20 71.9 0.1 7.4e-20 70.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESA04369.1 - 7.3e-13 48.2 0.3 1.9e-12 46.9 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ycf9 PF01737.12 ESA04371.1 - 0.0086 15.4 0.3 0.056 12.8 0.1 2.0 1 1 1 2 2 2 1 YCF9 DUF3815 PF12821.2 ESA04371.1 - 0.062 13.2 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3815) 7tm_1 PF00001.16 ESA04376.1 - 5.7e-10 38.7 13.9 5.7e-10 38.7 9.6 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Aldo_ket_red PF00248.16 ESA04377.1 - 0.00081 18.2 0.0 0.00084 18.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA04378.1 - 1.6e-47 161.6 0.0 1.9e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HAD_2 PF13419.1 ESA04378.1 - 0.0051 17.0 0.0 0.0071 16.5 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Aldo_ket_red PF00248.16 ESA04379.1 - 3.5e-84 281.9 0.0 4e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA04380.1 - 1.9e-35 122.0 0.0 2.1e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Na_Ca_ex PF01699.19 ESA04381.1 - 7.5e-25 87.1 20.1 3.2e-23 81.8 8.7 2.4 2 1 0 2 2 2 2 Sodium/calcium exchanger protein ATP-synt_8 PF00895.15 ESA04381.1 - 0.22 11.7 0.2 0.22 11.7 0.2 3.2 3 1 1 4 4 4 0 ATP synthase protein 8 Na_Ca_ex PF01699.19 ESA04383.1 - 9.6e-30 103.0 28.4 1.4e-20 73.3 5.4 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DUF2627 PF11118.3 ESA04383.1 - 0.14 12.2 0.1 0.14 12.2 0.1 3.7 4 1 1 5 5 5 0 Protein of unknown function (DUF2627) UBA PF00627.26 ESA04384.1 - 2.3e-10 39.9 0.3 4.4e-10 39.0 0.2 1.5 1 0 0 1 1 1 1 UBA/TS-N domain CUE PF02845.11 ESA04384.1 - 0.0024 17.3 0.1 0.0058 16.1 0.0 1.6 1 0 0 1 1 1 1 CUE domain DUF3530 PF12048.3 ESA04384.1 - 0.0056 15.7 1.6 0.0087 15.0 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) DnaG_DnaB_bind PF08278.6 ESA04384.1 - 0.049 13.8 0.2 6.5 6.9 0.1 2.2 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding Mucin PF01456.12 ESA04384.1 - 0.3 10.8 25.1 0.45 10.2 17.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Pox_A32 PF04665.7 ESA04386.1 - 2.2e-06 27.1 0.1 0.00066 19.0 0.0 2.1 2 0 0 2 2 2 2 Poxvirus A32 protein FtsK_SpoIIIE PF01580.13 ESA04386.1 - 0.0023 17.4 0.0 0.0042 16.5 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family DUF4379 PF14311.1 ESA04387.1 - 0.00079 19.1 30.2 0.11 12.3 0.8 4.0 4 0 0 4 4 4 3 Domain of unknown function (DUF4379) Thioredoxin_7 PF13899.1 ESA04387.1 - 1.1 9.3 12.1 2.9 7.9 0.0 4.9 5 0 0 5 5 5 0 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA04387.1 - 5.7 7.1 16.1 4.6 7.4 4.6 4.1 4 1 0 4 4 4 0 Thioredoxin-like domain Cys_rich_CPXG PF14255.1 ESA04387.1 - 8.6 6.2 7.8 28 4.6 0.1 4.1 4 0 0 4 4 4 0 Cysteine-rich CPXCG GRIM-19 PF06212.7 ESA04388.1 - 2.4e-35 121.0 0.0 3e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein DNA_pol_phi PF04931.8 ESA04389.1 - 8.2e-50 169.4 41.4 9.7e-32 109.6 18.2 3.0 2 1 0 2 2 2 2 DNA polymerase phi Zip PF02535.17 ESA04389.1 - 0.38 9.7 2.9 0.59 9.0 1.2 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Thioredoxin PF00085.15 ESA04390.1 - 1.2e-27 95.6 0.2 1.5e-27 95.3 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESA04390.1 - 1.1e-06 28.7 0.1 3.3e-05 23.9 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA04390.1 - 2.4e-06 27.6 0.1 2.6e-05 24.3 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESA04390.1 - 2.9e-06 27.2 0.0 5.1e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESA04390.1 - 4e-05 23.1 0.0 4.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 ESA04390.1 - 0.00082 19.0 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESA04390.1 - 0.01 15.3 0.1 0.013 15.0 0.0 1.3 1 0 0 1 1 1 0 Redoxin DIM1 PF02966.11 ESA04390.1 - 0.014 14.8 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin_6 PF13848.1 ESA04390.1 - 0.023 14.5 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain KaiB PF07689.7 ESA04390.1 - 0.033 13.6 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 KaiB domain DUF836 PF05768.9 ESA04390.1 - 0.081 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) ChAPs PF09295.5 ESA04391.1 - 3.5e-160 533.0 0.6 2.2e-158 527.1 0.0 2.2 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 ESA04391.1 - 1.1e-07 31.3 4.0 0.002 17.7 0.0 3.6 3 0 0 3 3 3 3 TPR repeat TPR_19 PF14559.1 ESA04391.1 - 6.1e-07 29.6 3.7 0.15 12.3 0.1 4.2 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA04391.1 - 5.2e-06 26.9 4.6 0.11 13.1 1.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA04391.1 - 6.5e-06 26.3 7.0 4.9 8.0 0.3 6.3 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA04391.1 - 5.5e-05 22.6 4.8 0.22 11.3 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA04391.1 - 0.00055 19.0 6.4 0.098 11.6 0.4 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA04391.1 - 0.0031 17.5 1.0 4.2 7.8 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA04391.1 - 0.004 17.0 7.6 0.53 10.2 0.1 4.8 3 2 2 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA04391.1 - 0.0076 16.3 6.9 0.47 10.6 0.6 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA04391.1 - 0.02 14.7 18.2 0.036 13.9 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA04391.1 - 0.77 9.4 4.4 2.2 8.0 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Mago-bind PF09282.5 ESA04392.1 - 7.8e-11 41.3 2.6 1.5e-10 40.4 1.8 1.5 1 0 0 1 1 1 1 Mago binding AAA_23 PF13476.1 ESA04392.1 - 0.038 14.2 10.9 0.047 14.0 7.5 1.1 1 0 0 1 1 1 0 AAA domain Matrilin_ccoil PF10393.4 ESA04392.1 - 0.36 10.2 6.8 0.42 10.0 0.5 3.0 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Nup54 PF13874.1 ESA04392.1 - 3.1 7.4 15.0 2.6 7.7 6.5 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Adeno_PIX PF03955.9 ESA04392.1 - 3.2 8.3 5.8 6.1 7.4 1.3 2.1 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) DUF3835 PF12927.2 ESA04393.1 - 1.5e-10 41.8 9.2 1.7e-10 41.6 1.3 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3835) ATP_bind_4 PF01902.12 ESA04393.1 - 0.065 12.5 0.2 0.086 12.1 0.1 1.2 1 0 0 1 1 1 0 ATP-binding region APO_RNA-bind PF05634.6 ESA04394.1 - 0.055 12.6 0.0 0.2 10.8 0.0 1.8 2 0 0 2 2 2 0 APO RNA-binding HMG_box PF00505.14 ESA04395.1 - 8.6e-05 22.7 0.0 0.00027 21.1 0.0 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box Rubella_E2 PF05749.6 ESA04395.1 - 1.8 7.7 4.1 4 6.6 0.0 2.1 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 Ribosomal_60s PF00428.14 ESA04397.1 - 0.088 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein LytTR PF04397.10 ESA04398.1 - 0.14 12.2 1.9 0.18 11.8 0.0 2.2 3 0 0 3 3 3 0 LytTr DNA-binding domain DUF2674 PF10879.3 ESA04399.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2674) DUF4051 PF13260.1 ESA04399.1 - 0.15 11.4 0.5 0.44 9.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) IceA2 PF05862.6 ESA04402.1 - 0.075 12.7 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein Dimer_Tnp_hAT PF05699.9 ESA04403.1 - 3.3e-05 23.4 0.0 3.3e-05 23.4 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF1580 PF07618.6 ESA04403.1 - 0.22 10.9 0.8 2.7 7.4 0.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1580) Dimer_Tnp_hAT PF05699.9 ESA04404.1 - 2.7e-05 23.6 1.1 3.9e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF2674 PF10879.3 ESA04405.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2674) BON PF04972.12 ESA04406.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 BON domain Herpes_ori_bp PF02399.10 ESA04407.1 - 1.5e-15 56.3 0.1 7.4e-15 53.9 0.1 1.8 2 0 0 2 2 2 1 Origin of replication binding protein Sel1 PF08238.7 ESA04410.1 - 2.4e-81 266.3 46.2 2.7e-13 50.0 0.6 8.1 7 1 1 8 8 8 7 Sel1 repeat TPR_6 PF13174.1 ESA04410.1 - 6.3e-12 45.1 22.1 0.71 10.4 0.2 8.0 7 1 0 7 7 7 5 Tetratricopeptide repeat MIT PF04212.13 ESA04410.1 - 6.3e-07 29.1 27.5 2.7 7.9 0.2 7.6 7 0 0 7 7 7 5 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESA04410.1 - 0.00021 21.8 6.2 0.6 10.8 0.1 4.3 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA04410.1 - 0.00088 19.2 16.6 4.6 7.6 0.0 8.3 7 1 0 7 7 7 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA04410.1 - 0.002 17.8 10.0 47 3.8 0.0 6.8 8 0 0 8 8 8 0 Lung surfactant protein D coiled-coil trimerisation zinc-ribbons_6 PF07191.7 ESA04410.1 - 0.0077 16.0 8.4 0.045 13.5 0.5 2.4 2 0 0 2 2 2 2 zinc-ribbons TPR_20 PF14561.1 ESA04410.1 - 0.046 13.8 5.3 10 6.2 0.0 4.2 2 2 3 5 5 5 0 Tetratricopeptide repeat ZipA_C PF04354.8 ESA04410.1 - 0.058 12.8 0.2 8.2 5.9 0.0 3.1 2 1 1 3 3 3 0 ZipA, C-terminal FtsZ-binding domain ApbA PF02558.11 ESA04410.1 - 0.17 11.2 0.8 38 3.7 0.0 3.3 3 1 0 4 4 4 0 Ketopantoate reductase PanE/ApbA PUL PF08324.6 ESA04410.1 - 0.34 9.6 2.3 21 3.7 0.0 3.2 1 1 3 4 4 4 0 PUL domain Foie-gras_1 PF11817.3 ESA04410.1 - 1.3 8.4 12.4 13 5.2 0.7 3.6 1 1 1 2 2 2 0 Foie gras liver health family 1 HTH_16 PF12645.2 ESA04410.1 - 2.9 7.8 12.5 75 3.3 0.0 5.7 7 1 1 8 8 8 0 Helix-turn-helix domain BTB PF00651.26 ESA04414.1 - 3.2e-19 68.9 0.5 4.4e-19 68.5 0.4 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA04414.1 - 0.043 12.9 0.6 0.05 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Urm1 PF09138.6 ESA04414.1 - 0.085 12.9 0.4 0.24 11.5 0.1 1.8 1 1 1 2 2 2 0 Urm1 (Ubiquitin related modifier) Grp1_Fun34_YaaH PF01184.14 ESA04415.1 - 1.5e-50 171.4 18.5 3.6e-50 170.1 12.8 1.6 1 1 0 1 1 1 1 GPR1/FUN34/yaaH family Pkinase_Tyr PF07714.12 ESA04418.1 - 3.1e-50 170.6 0.0 4.3e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04418.1 - 7.7e-48 162.8 0.2 1.6e-47 161.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA04418.1 - 2.3e-16 59.8 4.9 0.00039 20.9 0.0 4.0 4 0 0 4 4 4 3 Sel1 repeat TPR_11 PF13414.1 ESA04418.1 - 0.004 16.7 0.6 0.018 14.6 0.0 2.3 2 0 0 2 2 2 1 TPR repeat RIO1 PF01163.17 ESA04418.1 - 0.006 15.9 0.1 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA04418.1 - 0.01 14.9 0.1 0.02 13.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA04418.1 - 0.013 14.8 0.1 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TPR_12 PF13424.1 ESA04418.1 - 0.039 13.8 2.0 25 4.9 0.0 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat APH PF01636.18 ESA04418.1 - 0.11 12.1 0.1 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Apc3 PF12895.2 ESA04418.1 - 0.49 10.5 3.6 1.6 8.9 0.4 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.13 ESA04418.1 - 8.9 6.2 6.9 5.8 6.8 0.1 3.7 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Rhodanese PF00581.15 ESA04419.1 - 1.7e-26 92.7 0.0 1.9e-12 47.5 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain PGM_PMM_II PF02879.11 ESA04419.1 - 0.046 14.0 0.1 0.34 11.2 0.0 2.3 3 0 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF3704 PF12488.3 ESA04419.1 - 1.3 8.7 4.1 5.6 6.6 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3704) Phage_int_SAM_3 PF14659.1 ESA04422.1 - 0.014 15.6 0.9 0.014 15.6 0.6 3.5 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain UCR_UQCRX_QCR9 PF05365.7 ESA04423.1 - 0.024 14.2 2.6 0.85 9.2 0.0 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Frigida PF07899.6 ESA04423.1 - 0.089 11.5 0.0 0.089 11.5 0.0 1.1 1 0 0 1 1 1 0 Frigida-like protein PrmA PF06325.8 ESA04424.1 - 0.77 8.8 6.6 1 8.4 4.6 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2681 PF10883.3 ESA04424.1 - 3.6 7.8 15.1 0.94 9.7 8.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) MutS_III PF05192.13 ESA04425.1 - 0.76 9.5 17.9 1.6 8.4 5.0 3.1 1 1 2 3 3 3 0 MutS domain III Ifi-6-16 PF06140.8 ESA04426.1 - 1.8e-10 40.4 17.0 3e-10 39.7 11.8 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family Gly-zipper_Omp PF13488.1 ESA04426.1 - 2.4 7.8 14.6 0.14 11.7 3.8 2.5 2 0 0 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.10 ESA04426.1 - 2.8 7.6 17.5 0.13 11.9 6.5 2.4 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 ESA04426.1 - 4.6 6.9 8.2 0.21 11.2 0.8 2.1 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Ifi-6-16 PF06140.8 ESA04427.1 - 1.1e-11 44.2 12.5 1.8e-11 43.6 8.7 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family Gly-zipper_OmpA PF13436.1 ESA04427.1 - 0.13 11.8 1.6 0.36 10.5 1.1 1.7 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_Omp PF13488.1 ESA04427.1 - 2.5 7.7 15.2 0.034 13.7 4.3 2.1 2 0 0 2 2 2 0 Glycine zipper Rick_17kDa_Anti PF05433.10 ESA04427.1 - 9.3 6.0 22.9 0.038 13.6 6.9 2.2 2 0 0 2 2 2 0 Glycine zipper 2TM domain DUF1351 PF07083.6 ESA04429.1 - 0.00059 19.5 14.6 0.023 14.3 2.8 2.4 1 1 2 3 3 3 2 Protein of unknown function (DUF1351) Apolipoprotein PF01442.13 ESA04429.1 - 0.001 18.6 0.2 0.0054 16.2 0.1 1.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Syntaxin_2 PF14523.1 ESA04429.1 - 0.0045 16.9 17.7 0.2 11.6 1.1 3.0 1 1 3 4 4 4 4 Syntaxin-like protein DUF883 PF05957.8 ESA04429.1 - 0.005 17.1 0.4 3.4 8.1 0.1 2.8 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.7 ESA04429.1 - 0.0085 15.9 11.2 0.45 10.3 6.7 2.5 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.2 ESA04429.1 - 0.018 15.3 7.1 0.51 10.7 1.4 2.8 1 1 1 2 2 2 0 YtxH-like protein DNA_pack_N PF02500.10 ESA04429.1 - 0.061 12.8 3.2 0.078 12.5 2.2 1.3 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus YlqD PF11068.3 ESA04429.1 - 0.069 13.1 11.1 7.9 6.5 7.7 2.3 1 1 0 1 1 1 0 YlqD protein MKT1_N PF12247.3 ESA04429.1 - 0.11 12.8 0.4 14 6.0 0.0 2.7 1 1 1 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Phasin PF05597.6 ESA04429.1 - 0.12 12.1 3.1 4.8 6.9 0.1 2.6 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PSII_Pbs27 PF13326.1 ESA04429.1 - 0.13 12.2 1.6 12 5.8 0.1 2.6 1 1 2 3 3 3 0 Photosystem II Pbs27 Phe_tRNA-synt_N PF02912.13 ESA04429.1 - 0.13 11.9 7.1 9.3 6.0 0.5 3.8 2 2 1 4 4 4 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF4229 PF14012.1 ESA04429.1 - 0.16 11.8 0.2 44 4.0 0.0 3.3 2 2 0 3 3 3 0 Protein of unknown function (DUF4229) MADF_DNA_bdg PF10545.4 ESA04429.1 - 0.2 11.8 1.6 5.8 7.1 0.1 2.7 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like IATP PF04568.7 ESA04429.1 - 0.3 11.1 4.9 18 5.4 0.1 3.5 3 1 0 3 3 3 0 Mitochondrial ATPase inhibitor, IATP DinB PF05163.7 ESA04429.1 - 0.32 10.7 1.7 14 5.3 0.1 2.3 1 1 1 2 2 2 0 DinB family Troponin PF00992.15 ESA04429.1 - 0.35 10.9 3.6 0.51 10.3 2.4 1.5 1 1 0 1 1 1 0 Troponin HLH PF00010.21 ESA04429.1 - 0.48 10.1 13.0 4.2 7.1 0.2 4.3 3 1 0 3 3 3 0 Helix-loop-helix DNA-binding domain DUF4446 PF14584.1 ESA04429.1 - 0.64 9.8 5.3 4 7.2 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) FemAB PF02388.11 ESA04429.1 - 0.69 8.5 10.0 1.6 7.3 5.8 1.9 1 1 1 2 2 2 0 FemAB family DUF3810 PF12725.2 ESA04429.1 - 0.75 8.6 6.1 1.4 7.7 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF4404 PF14357.1 ESA04429.1 - 0.91 9.9 5.6 1.7 9.1 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) HSCB_C PF07743.8 ESA04429.1 - 0.92 10.0 5.4 13 6.3 0.9 2.9 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain Imm2 PF14426.1 ESA04429.1 - 0.99 9.4 7.5 11 6.0 0.3 3.5 2 1 2 4 4 4 0 Immunity protein Imm2 Flagellin_N PF00669.15 ESA04429.1 - 1.2 8.9 12.4 4.8 6.9 3.2 2.2 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region DUF1104 PF06518.6 ESA04429.1 - 1.5 8.9 5.4 3.4 7.8 0.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1104) FUN14 PF04930.10 ESA04429.1 - 1.8 8.9 5.8 1.3e+02 2.9 4.0 2.5 1 1 0 1 1 1 0 FUN14 family DUF4014 PF13198.1 ESA04429.1 - 2 8.8 5.2 1.2e+02 3.1 2.6 3.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4014) DEK_C PF08766.6 ESA04429.1 - 2.5 7.9 10.2 8.7 6.2 0.1 4.2 1 1 1 3 3 3 0 DEK C terminal domain ATP-synt_B PF00430.13 ESA04429.1 - 3 7.6 7.8 7.4 6.3 5.4 1.8 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Fib_alpha PF08702.5 ESA04429.1 - 3.8 7.6 15.9 11 6.0 11.1 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family NIT PF08376.5 ESA04429.1 - 4 6.8 7.5 50 3.3 5.2 2.1 1 1 0 1 1 1 0 Nitrate and nitrite sensing TMF_DNA_bd PF12329.3 ESA04429.1 - 5.7 6.8 6.0 9.2 6.1 0.9 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding ADPrib_exo_Tox PF03496.9 ESA04429.1 - 7 5.8 12.9 12 5.0 8.9 1.4 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme UPF0118 PF01594.11 ESA04429.1 - 7.6 5.4 7.5 7.6 5.4 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF20 CorA PF01544.13 ESA04429.1 - 8.1 5.3 15.1 5.8 5.8 5.3 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF3664 PF12406.3 ESA04429.1 - 8.6 7.0 18.7 3 8.4 4.0 2.8 1 1 1 2 2 2 0 Surface protein Ifi-6-16 PF06140.8 ESA04430.1 - 1.6e-08 34.1 12.7 2.6e-08 33.5 8.8 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family DUF896 PF05979.7 ESA04430.1 - 0.035 13.6 6.1 6.8 6.3 0.2 4.2 1 1 0 3 3 3 0 Bacterial protein of unknown function (DUF896) POTRA_2 PF08479.6 ESA04430.1 - 0.33 10.6 3.4 1.2 8.8 0.4 2.6 1 1 2 3 3 3 0 POTRA domain, ShlB-type HrcA PF01628.16 ESA04430.1 - 0.64 9.5 5.1 3.3 7.2 1.6 2.8 1 1 1 2 2 2 0 HrcA protein C terminal domain DUF445 PF04286.7 ESA04430.1 - 1.3 8.4 12.1 4.1 6.8 8.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF445) DUF2666 PF10869.3 ESA04430.1 - 3.8 7.5 11.6 0.17 11.9 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2666) Syntaxin_2 PF14523.1 ESA04430.1 - 5.5 7.0 15.5 1.8 8.6 4.6 2.8 1 1 1 2 2 2 0 Syntaxin-like protein Bromodomain PF00439.20 ESA04431.1 - 8.8e-20 70.4 0.2 9.9e-20 70.2 0.2 1.0 1 0 0 1 1 1 1 Bromodomain Kelch_4 PF13418.1 ESA04432.1 - 8.1e-23 79.9 17.6 0.00045 19.9 0.3 6.8 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA04432.1 - 3.4e-20 71.6 5.5 0.00021 21.3 0.1 6.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA04432.1 - 3.9e-14 52.2 21.9 0.011 15.6 0.3 6.9 6 1 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 ESA04432.1 - 4.2e-13 48.8 24.5 0.015 15.4 0.1 7.2 4 2 2 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA04432.1 - 1.3e-09 37.4 8.7 0.22 11.3 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA04432.1 - 1.4e-09 37.3 20.4 0.0017 17.8 0.0 5.4 6 0 0 6 6 6 3 Kelch motif DUF4446 PF14584.1 ESA04432.1 - 0.088 12.6 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) VASP_tetra PF08776.6 ESA04432.1 - 0.9 8.9 5.2 1 8.7 1.0 2.4 1 1 1 2 2 2 0 VASP tetramerisation domain ORC6 PF05460.8 ESA04432.1 - 0.95 8.4 7.6 1.8 7.5 5.3 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) YjgP_YjgQ PF03739.9 ESA04432.1 - 1.4 7.5 6.4 15 4.1 2.6 2.2 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family PIF1 PF05970.9 ESA04436.1 - 0.00011 21.3 0.4 0.0023 16.9 0.2 2.1 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 ESA04436.1 - 0.013 15.1 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain RGS PF00615.14 ESA04436.1 - 0.015 15.3 0.2 0.026 14.6 0.1 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain F-box-like PF12937.2 ESA04437.1 - 0.00011 21.9 2.0 0.00022 20.8 1.4 1.6 1 1 0 1 1 1 1 F-box-like SpoIISA_toxin PF14171.1 ESA04440.1 - 0.077 12.2 2.8 0.1 11.8 1.9 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system PALP PF00291.20 ESA04441.1 - 8.2e-61 205.8 0.0 1.1e-60 205.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 ESA04441.1 - 4.2e-12 45.6 0.1 2.8e-07 30.1 0.0 2.8 2 1 0 2 2 2 2 CBS domain Dexa_ind PF15198.1 ESA04441.1 - 0.13 12.1 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Dexamethasone-induced DUF1708 PF08101.6 ESA04442.1 - 7e-06 25.1 1.0 9.2e-06 24.7 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) Sld5 PF05916.6 ESA04442.1 - 0.028 14.7 0.4 0.055 13.7 0.3 1.6 1 0 0 1 1 1 0 GINS complex protein PDZ_assoc PF10600.4 ESA04443.1 - 0.0091 16.2 0.3 0.022 15.0 0.2 1.7 1 0 0 1 1 1 1 PDZ-associated domain of NMDA receptors F-box-like PF12937.2 ESA04444.1 - 2.9e-06 26.8 1.9 2.9e-06 26.8 1.3 2.2 2 0 0 2 2 2 1 F-box-like LRR_7 PF13504.1 ESA04444.1 - 0.075 13.2 3.7 59 4.5 0.0 5.3 3 1 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 ESA04444.1 - 0.48 10.6 11.2 1.8 8.8 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich repeat FMN_red PF03358.10 ESA04445.1 - 3.9e-35 120.5 0.0 4.7e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 ESA04445.1 - 6.7e-08 32.2 0.0 8.1e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.10 ESA04446.1 - 3.7e-37 127.1 0.0 4.6e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 ESA04446.1 - 1.8e-07 30.8 0.0 1.9e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold UTP15_C PF09384.5 ESA04447.1 - 0.00011 21.8 0.0 0.036 13.7 0.0 2.6 1 1 1 2 2 2 2 UTP15 C terminal Phage_DsbA PF11126.3 ESA04447.1 - 0.0062 16.5 2.3 0.042 13.9 0.2 2.7 2 0 0 2 2 2 1 Transcriptional regulator DsbA EF_TS PF00889.14 ESA04448.1 - 8.5e-29 100.4 0.0 6.6e-24 84.4 0.0 2.6 1 1 1 2 2 2 2 Elongation factor TS HBS1_N PF08938.5 ESA04448.1 - 0.049 13.7 0.2 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 HBS1 N-terminus UBA PF00627.26 ESA04448.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain DUF3989 PF13150.1 ESA04448.1 - 0.11 12.0 0.5 0.24 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) DUF647 PF04884.9 ESA04449.1 - 3.4e-58 196.7 0.3 4.8e-58 196.3 0.2 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DUF1673 PF07895.6 ESA04450.1 - 0.26 10.7 4.9 0.47 9.9 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF2873 PF11395.3 ESA04450.1 - 9.8 5.8 8.0 74 3.0 4.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2873) Transposase_mut PF00872.13 ESA04451.1 - 0.014 13.9 0.3 0.026 13.0 0.2 1.3 1 0 0 1 1 1 0 Transposase, Mutator family Hpr_kinase_C PF07475.7 ESA04452.1 - 0.096 11.9 0.0 0.098 11.9 0.0 1.0 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Borrelia_lipo_2 PF06238.6 ESA04454.1 - 0.0029 17.6 5.8 0.22 11.6 0.4 2.1 1 1 1 2 2 2 2 Borrelia burgdorferi BBR25 lipoprotein RLI PF04068.10 ESA04455.1 - 0.079 12.5 0.5 0.17 11.5 0.3 1.5 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI SNF2_N PF00176.18 ESA04456.1 - 8.5e-81 271.0 0.2 8.5e-81 271.0 0.1 2.6 3 0 0 3 3 3 1 SNF2 family N-terminal domain Bromodomain PF00439.20 ESA04456.1 - 8e-22 76.9 0.8 8e-22 76.9 0.5 2.3 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.26 ESA04456.1 - 1.9e-17 62.8 0.0 7.4e-16 57.7 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 ESA04456.1 - 2.9e-16 59.3 3.1 2.9e-16 59.3 2.2 4.1 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.8 ESA04456.1 - 8.2e-06 25.5 2.5 8.2e-06 25.5 1.7 4.3 4 1 1 5 5 5 1 HSA Pro_isomerase PF00160.16 ESA04457.1 - 1.4e-49 168.2 0.4 1.6e-49 168.1 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 ESA04458.1 - 1.1e-19 69.5 4.3 1.3e-10 40.7 0.6 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat DUF1299 PF06975.6 ESA04459.1 - 0.93 9.3 3.4 3.6 7.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1299) SET PF00856.23 ESA04460.1 - 2.1e-28 99.6 0.2 6.3e-28 98.1 0.2 1.7 1 1 0 1 1 1 1 SET domain zf-C4pol PF14260.1 ESA04461.1 - 0.019 14.9 2.9 0.021 14.8 1.0 1.8 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta ubiquitin PF00240.18 ESA04461.1 - 0.029 13.7 0.3 0.061 12.7 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin family NPV_P10 PF05531.7 ESA04461.1 - 0.083 13.1 1.3 7.4 6.8 0.1 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 ESA04461.1 - 0.12 12.2 1.9 0.2 11.5 0.1 2.3 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Sec62 PF03839.11 ESA04462.1 - 0.011 15.1 1.6 0.011 15.1 1.1 1.4 1 1 0 1 1 1 0 Translocation protein Sec62 Myb_DNA-bind_4 PF13837.1 ESA04463.1 - 8.8e-07 28.9 4.1 1.3e-06 28.4 2.9 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA04463.1 - 0.005 16.9 2.9 0.0088 16.2 2.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.1 ESA04463.1 - 0.014 15.3 0.7 0.029 14.2 0.5 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA04463.1 - 0.049 14.2 4.4 0.08 13.5 3.1 1.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA04463.1 - 0.23 11.6 1.9 0.49 10.5 1.3 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain Pkinase PF00069.20 ESA04464.1 - 8.2e-28 97.2 0.0 1.4e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04464.1 - 2.7e-26 92.2 0.0 3.4e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04464.1 - 0.024 14.3 0.1 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Baculo_VP1054 PF05789.6 ESA04465.1 - 0.0034 16.6 0.3 0.0041 16.3 0.2 1.0 1 0 0 1 1 1 1 Baculovirus VP1054 protein SAPS PF04499.10 ESA04465.1 - 0.057 12.0 0.1 0.07 11.7 0.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CX PF01705.14 ESA04465.1 - 0.068 13.1 0.6 0.1 12.5 0.1 1.6 2 0 0 2 2 2 0 CX module Scaffolding_pro PF11418.3 ESA04468.1 - 0.12 12.7 0.2 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 Phi29 scaffolding protein DDE_1 PF03184.14 ESA04472.1 - 5.7e-16 58.3 0.3 7.9e-16 57.8 0.1 1.2 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA04472.1 - 0.0033 17.1 0.1 0.0068 16.1 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF1798 PF08807.5 ESA04472.1 - 0.0097 15.6 1.3 0.015 15.0 0.9 1.3 1 0 0 1 1 1 1 Bacterial domain of unknown function (DUF1798) UPF0697 PF15117.1 ESA04472.1 - 0.061 13.0 1.0 0.11 12.2 0.7 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0697 Dimer_Tnp_hAT PF05699.9 ESA04473.1 - 3.7e-13 48.9 0.7 1.2e-12 47.2 0.1 2.1 2 1 0 2 2 2 1 hAT family C-terminal dimerisation region Phage_gp49_66 PF13876.1 ESA04474.1 - 0.12 12.4 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family Uma2 PF05685.7 ESA04476.1 - 1.4e-05 24.5 0.0 1.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease Beta-Casp PF10996.3 ESA04478.1 - 2e-12 47.1 0.0 4e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain ALO PF04030.9 ESA04480.1 - 8e-16 58.4 1.0 1.2e-15 57.8 0.7 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESA04480.1 - 3.8e-14 52.3 2.4 4.8e-13 48.7 1.7 2.1 1 1 0 1 1 1 1 FAD binding domain Synaptobrevin PF00957.16 ESA04482.1 - 3.1e-25 87.5 4.0 3.6e-25 87.3 2.8 1.0 1 0 0 1 1 1 1 Synaptobrevin Vps5 PF09325.5 ESA04482.1 - 0.037 13.2 0.3 0.042 13.0 0.2 1.0 1 0 0 1 1 1 0 Vps5 C terminal like Fzo_mitofusin PF04799.8 ESA04482.1 - 0.098 12.0 2.5 0.057 12.8 0.6 1.5 1 1 0 1 1 1 0 fzo-like conserved region DUF1664 PF07889.7 ESA04482.1 - 6.1 6.6 6.7 1.6 8.5 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APH PF01636.18 ESA04483.1 - 8.9e-13 48.5 0.0 2.1e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ESA04483.1 - 0.00051 19.2 0.8 0.0013 17.9 0.0 1.8 1 1 1 2 2 2 1 Ecdysteroid kinase Ferritin-like PF12902.2 ESA04484.1 - 0.00051 19.7 0.0 0.00095 18.8 0.0 1.4 1 1 0 1 1 1 1 Ferritin-like Occludin_ELL PF07303.8 ESA04484.1 - 0.016 15.9 0.8 2.1 9.1 0.1 2.2 1 1 1 2 2 2 0 Occludin homology domain VGCC_beta4Aa_N PF12052.3 ESA04484.1 - 0.061 13.2 1.0 0.094 12.5 0.7 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Spectrin PF00435.16 ESA04484.1 - 0.12 12.6 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 Spectrin repeat Tox-ART-HYE1 PF15634.1 ESA04485.1 - 0.098 11.6 4.6 0.45 9.4 0.2 2.1 2 0 0 2 2 2 0 HYE1 signature containing ADP-ribosyltransferase GAD PF02938.9 ESA04489.1 - 0.081 13.0 0.1 0.094 12.8 0.1 1.1 1 0 0 1 1 1 0 GAD domain DUF4325 PF14213.1 ESA04489.1 - 0.1 12.2 0.1 6.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4325) LRR_4 PF12799.2 ESA04490.1 - 9.3e-05 21.9 17.6 0.03 13.9 4.1 4.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA04490.1 - 0.002 17.8 11.2 0.21 11.3 6.7 3.2 1 1 1 2 2 2 1 Leucine rich repeat LRR_7 PF13504.1 ESA04490.1 - 0.004 17.1 12.3 11 6.6 0.5 5.8 4 2 1 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 ESA04490.1 - 0.016 15.2 13.7 0.37 11.0 1.8 5.0 3 1 2 5 5 5 0 Leucine Rich repeat Cytochrom_C_2 PF01322.15 ESA04490.1 - 0.12 12.8 0.1 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C' ELH PF02323.10 ESA04490.1 - 0.17 11.0 2.2 0.62 9.1 0.6 2.0 1 1 1 2 2 2 0 Egg-laying hormone precursor LRR_5 PF13306.1 ESA04490.1 - 1.5 8.5 6.7 0.47 10.1 1.2 2.4 2 1 0 2 2 2 0 Leucine rich repeats (6 copies) LRR_1 PF00560.28 ESA04490.1 - 4.1 7.7 13.8 68 4.1 0.0 5.1 2 1 1 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.1 ESA04491.1 - 0.013 15.4 9.7 0.28 11.3 0.9 4.6 3 1 1 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 ESA04491.1 - 0.034 14.3 5.9 29 5.4 0.3 5.1 4 1 1 5 5 5 0 Leucine rich repeat Cas_Cas4 PF01930.12 ESA04491.1 - 0.32 10.9 3.5 0.64 9.9 2.4 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF83 PIN_2 PF10130.4 ESA04491.1 - 0.83 9.6 7.2 0.77 9.7 1.3 2.6 1 1 2 3 3 3 0 PIN domain LRR_4 PF12799.2 ESA04491.1 - 0.87 9.2 20.2 0.27 10.9 3.9 4.3 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA04491.1 - 2.6 8.4 6.2 1.8e+02 2.7 2.2 4.6 2 1 0 3 3 3 0 Leucine Rich Repeat DUF342 PF03961.8 ESA04491.1 - 6.4 5.0 20.9 7.1 4.9 12.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF342) LRR_8 PF13855.1 ESA04492.1 - 0.14 11.9 8.1 3.1 7.6 5.6 2.8 1 1 1 2 2 2 0 Leucine rich repeat LRR_7 PF13504.1 ESA04492.1 - 0.15 12.3 4.3 42 4.9 0.3 4.7 2 1 1 3 3 3 0 Leucine rich repeat LRR_4 PF12799.2 ESA04492.1 - 0.15 11.6 13.9 2 8.1 5.9 3.2 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) TAP_C PF03943.8 ESA04494.1 - 0.06 12.7 0.3 0.3 10.5 0.1 2.0 2 0 0 2 2 2 0 TAP C-terminal domain GxDLY PF14607.1 ESA04495.1 - 0.072 12.5 0.4 0.15 11.5 0.3 1.5 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type RecX PF02631.11 ESA04498.1 - 0.0073 16.5 3.0 0.02 15.1 2.1 1.8 1 0 0 1 1 1 1 RecX family PAH PF02671.16 ESA04498.1 - 0.059 12.9 0.1 6.5 6.4 0.0 2.7 2 0 0 2 2 2 0 Paired amphipathic helix repeat YpjP PF14005.1 ESA04498.1 - 0.084 12.6 7.0 0.022 14.5 1.6 2.4 1 1 1 2 2 2 0 YpjP-like protein DUF883 PF05957.8 ESA04498.1 - 0.095 13.1 0.3 0.6 10.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF2315 PF10231.4 ESA04498.1 - 3 7.7 17.0 0.29 10.9 0.1 3.5 3 1 1 4 4 4 0 Uncharacterised conserved protein (DUF2315) LSM PF01423.17 ESA04499.1 - 3.5e-16 58.5 0.2 5.6e-16 57.8 0.1 1.3 1 0 0 1 1 1 1 LSM domain Pkinase PF00069.20 ESA04500.1 - 3.2e-14 52.7 0.0 3.4e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04500.1 - 4.6e-12 45.5 0.0 4.9e-12 45.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04500.1 - 0.00026 20.8 0.1 0.00036 20.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA04501.1 - 2.8e-08 33.1 0.7 0.0086 15.1 0.1 3.3 1 1 2 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA04501.1 - 7.7e-08 31.7 3.5 0.00022 20.4 0.6 3.2 1 1 2 3 3 3 2 Protein kinase domain Mononeg_RNA_pol PF00946.14 ESA04501.1 - 0.0083 13.5 0.1 0.14 9.4 0.0 2.0 2 0 0 2 2 2 1 Mononegavirales RNA dependent RNA polymerase APH PF01636.18 ESA04501.1 - 0.075 12.7 0.2 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Calici_PP_N PF08405.6 ESA04501.1 - 0.08 11.7 0.0 0.18 10.5 0.0 1.6 2 0 0 2 2 2 0 Viral polyprotein N-terminal WaaY PF06176.6 ESA04501.1 - 0.08 12.1 0.1 0.15 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ESA04505.1 - 7e-45 150.4 21.3 9.7e-07 29.2 0.1 8.7 8 1 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA04505.1 - 0.00033 20.9 7.2 2.2 8.9 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat Sel1 PF08238.7 ESA04506.1 - 5.1e-27 93.6 23.5 5.1e-07 30.1 0.0 6.6 7 0 0 7 7 7 5 Sel1 repeat TPR_6 PF13174.1 ESA04506.1 - 0.00016 21.8 6.4 0.2 12.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA04506.1 - 0.91 9.6 13.5 0.078 13.1 2.4 3.5 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.7 ESA04507.1 - 2e-29 101.3 21.0 5.5e-08 33.2 0.3 6.2 6 0 0 6 6 6 5 Sel1 repeat DUF977 PF06163.6 ESA04507.1 - 0.074 12.7 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) FAD_binding_6 PF00970.19 ESA04507.1 - 0.097 12.8 0.0 19 5.4 0.0 2.9 3 0 0 3 3 3 0 Oxidoreductase FAD-binding domain TPR_6 PF13174.1 ESA04507.1 - 1 9.9 5.0 37 5.0 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA04508.1 - 1.4e-43 146.3 18.4 9.1e-10 38.8 0.1 7.3 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA04508.1 - 0.0028 18.0 4.2 24 5.6 0.5 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Msg2_C PF12373.3 ESA04508.1 - 0.34 10.1 1.0 1.5 8.0 0.0 2.3 3 0 0 3 3 3 0 Major surface glycoprotein 2 C terminal Sel1 PF08238.7 ESA04509.1 - 1.4e-30 105.0 0.5 2.8e-07 30.9 0.0 4.4 4 0 0 4 4 4 4 Sel1 repeat Pkinase PF00069.20 ESA04509.1 - 5.7e-28 97.7 1.5 1.8e-27 96.1 1.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04509.1 - 2.6e-25 88.9 0.2 2e-23 82.8 0.1 3.0 1 1 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.13 ESA04509.1 - 0.19 11.6 9.6 1.6 8.6 0.5 3.5 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain Pkinase PF00069.20 ESA04511.1 - 8.5e-73 244.6 0.0 1.1e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04511.1 - 9.3e-44 149.4 0.0 1.2e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA04511.1 - 2.2e-08 33.4 0.0 4e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA04511.1 - 0.0073 16.0 0.4 0.18 11.4 0.2 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA04511.1 - 0.044 12.8 0.1 0.072 12.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family p450 PF00067.17 ESA04513.1 - 1.3e-34 119.5 0.0 4.7e-34 117.6 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Clat_adaptor_s PF01217.15 ESA04515.1 - 2.5e-43 147.1 2.6 3e-43 146.9 1.8 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4218 PF13960.1 ESA04517.1 - 0.0053 16.1 0.1 0.0058 16.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DASH_Duo1 PF08651.5 ESA04518.1 - 0.0035 16.8 0.3 1.1 8.8 0.0 3.1 3 0 0 3 3 3 2 DASH complex subunit Duo1 Sugar_tr PF00083.19 ESA04518.1 - 0.065 11.7 0.0 0.099 11.1 0.0 1.2 1 0 0 1 1 1 0 Sugar (and other) transporter B_lectin PF01453.19 ESA04519.1 - 0.0079 16.0 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 D-mannose binding lectin GBP_C PF02841.9 ESA04519.1 - 0.045 12.9 0.3 0.054 12.6 0.2 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain BACON PF13004.2 ESA04519.1 - 0.046 13.9 0.4 0.089 13.0 0.1 1.5 2 0 0 2 2 2 0 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal Lipocalin PF00061.18 ESA04519.1 - 0.053 13.5 1.5 0.088 12.7 0.9 1.5 1 1 1 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family Methuselah_N PF06652.7 ESA04519.1 - 0.066 12.7 0.3 0.078 12.5 0.2 1.1 1 0 0 1 1 1 0 Methuselah N-terminus FixG_C PF11614.3 ESA04519.1 - 0.11 12.6 1.0 0.2 11.7 0.7 1.5 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase PI31_Prot_N PF11566.3 ESA04519.1 - 0.21 11.1 2.8 0.35 10.4 2.0 1.6 1 1 0 1 1 1 0 PI31 proteasome regulator N-terminal UvrD_C PF13361.1 ESA04522.1 - 4.7e-16 59.1 5.7 5.6e-09 35.9 0.0 4.3 3 1 1 4 4 4 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 ESA04522.1 - 9.1e-08 32.1 0.8 2.5e-06 27.5 0.6 3.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ESA04522.1 - 3e-05 23.4 5.2 3e-05 23.4 3.6 4.4 3 2 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 ESA04522.1 - 0.0021 18.2 0.0 0.017 15.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain TPR_2 PF07719.12 ESA04522.1 - 0.007 16.1 11.6 0.014 15.2 0.1 4.3 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA04522.1 - 0.019 14.6 0.6 0.019 14.6 0.4 3.8 3 1 1 4 4 4 0 TPR repeat AAA_16 PF13191.1 ESA04522.1 - 0.15 12.0 0.0 0.45 10.4 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain TPR_12 PF13424.1 ESA04522.1 - 0.37 10.7 7.4 7.6 6.5 0.2 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA04522.1 - 5.7 6.7 14.3 0.15 11.7 0.1 4.5 3 1 0 4 4 4 0 Tetratricopeptide repeat DUF3336 PF11815.3 ESA04524.1 - 2.6e-44 150.2 2.2 2.6e-44 150.2 1.5 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3336) Patatin PF01734.17 ESA04524.1 - 1.7e-27 96.7 0.0 3.8e-27 95.5 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase MRL1 PF13003.2 ESA04524.1 - 0.02 14.7 0.1 0.046 13.5 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L1 Glyco_transf_8 PF01501.15 ESA04525.1 - 1.3e-16 60.6 0.2 6.5e-16 58.4 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 PIG-U PF06728.8 ESA04527.1 - 5.2e-81 272.4 23.2 5.2e-81 272.4 16.1 1.5 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U Sel1 PF08238.7 ESA04530.1 - 9.7e-27 92.8 3.1 1.2e-12 48.0 0.4 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_11 PF13414.1 ESA04530.1 - 0.37 10.4 5.1 2.4 7.8 3.1 2.5 1 1 2 3 3 3 0 TPR repeat MIT PF04212.13 ESA04530.1 - 0.37 10.6 7.5 0.41 10.5 2.1 3.0 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA04530.1 - 0.48 10.3 3.9 14 5.7 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.2 ESA04531.1 - 2.5e-60 200.8 12.4 8.8e-16 58.0 0.1 11.1 3 2 4 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 ESA04531.1 - 7.7e-50 164.3 6.8 2.2e-05 23.9 0.0 15.2 15 0 0 15 15 15 10 Ankyrin repeat Ank_3 PF13606.1 ESA04531.1 - 4.8e-35 116.0 14.7 0.0005 20.0 0.0 17.1 18 0 0 18 18 18 6 Ankyrin repeat Ank_5 PF13857.1 ESA04531.1 - 2.3e-34 116.6 4.1 4.3e-07 29.9 0.0 12.9 12 2 2 14 14 14 6 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESA04531.1 - 1.7e-33 114.3 7.1 7.5e-06 26.3 0.1 11.7 9 3 3 12 12 12 7 Ankyrin repeats (many copies) F-box-like PF12937.2 ESA04533.1 - 0.01 15.5 0.4 0.04 13.6 0.3 2.1 1 0 0 1 1 1 0 F-box-like Eaf7 PF07904.8 ESA04534.1 - 0.029 14.3 0.3 0.28 11.1 0.0 2.4 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Pkinase PF00069.20 ESA04536.1 - 8.4e-34 116.8 0.1 1.9e-33 115.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04536.1 - 6.2e-33 113.9 0.0 8.8e-33 113.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04536.1 - 0.11 12.1 0.1 0.25 11.0 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4211 PF13926.1 ESA04536.1 - 0.58 9.5 4.4 0.78 9.1 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4211) DUF3883 PF13020.1 ESA04537.1 - 0.028 14.1 0.4 0.055 13.2 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3883) DUF2839 PF10999.3 ESA04537.1 - 0.14 12.1 0.2 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) YL1 PF05764.8 ESA04537.1 - 0.41 10.2 3.0 0.49 9.9 2.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein PI3_PI4_kinase PF00454.22 ESA04538.1 - 2.8e-36 125.1 0.0 1.8e-35 122.5 0.0 2.3 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 ESA04538.1 - 1.7e-25 89.2 0.1 4e-25 88.0 0.1 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) zf-B_box PF00643.19 ESA04542.1 - 0.71 9.8 6.0 1.3 8.9 4.1 1.4 1 0 0 1 1 1 0 B-box zinc finger GP41 PF00517.12 ESA04543.1 - 0.096 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Retroviral envelope protein ORC6 PF05460.8 ESA04544.1 - 0.37 9.8 11.4 0.57 9.2 7.9 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SlyX PF04102.7 ESA04544.1 - 0.6 10.5 4.4 1.5 9.2 0.1 2.8 2 1 0 2 2 2 0 SlyX DUF3474 PF11960.3 ESA04544.1 - 0.63 10.0 5.1 1.3 9.0 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) Macoilin PF09726.4 ESA04544.1 - 1.3 7.2 15.4 1.7 6.8 10.7 1.2 1 0 0 1 1 1 0 Transmembrane protein Ndc1_Nup PF09531.5 ESA04544.1 - 2.9 6.2 12.2 3.6 5.9 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.17 ESA04544.1 - 8.1 5.3 5.7 13 4.6 4.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Dynamin_M PF01031.15 ESA04547.1 - 6.2e-111 369.8 0.0 1.7e-110 368.4 0.0 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 ESA04547.1 - 3.3e-55 186.4 2.4 3.4e-55 186.3 0.2 2.1 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 ESA04547.1 - 2.5e-32 110.6 5.6 2.9e-32 110.4 2.9 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 ESA04547.1 - 0.00017 21.5 0.2 0.00061 19.7 0.2 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase Baculo_p74 PF04583.7 ESA04547.1 - 0.0053 15.9 0.6 3.4 6.7 0.0 2.6 2 1 0 3 3 3 2 Baculoviridae p74 conserved region Miro PF08477.8 ESA04547.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Pkinase_Tyr PF07714.12 ESA04548.1 - 1.1e-43 149.2 0.0 1.6e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04548.1 - 2.2e-38 131.8 0.1 4.1e-38 131.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA04548.1 - 0.053 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.24 ESA04554.1 - 1.7e-16 60.6 0.0 4.5e-16 59.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA04554.1 - 0.00011 22.3 0.1 0.0009 19.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA04554.1 - 0.00013 21.9 0.0 0.00028 20.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Zot PF05707.7 ESA04554.1 - 0.00017 21.0 0.1 0.0021 17.5 0.1 2.5 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_5 PF07728.9 ESA04554.1 - 0.00087 19.0 0.0 0.0024 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESA04554.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain DUF3543 PF12063.3 ESA04554.1 - 0.014 14.5 0.1 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) AAA_24 PF13479.1 ESA04554.1 - 0.024 14.1 0.0 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESA04554.1 - 0.025 14.1 0.1 0.2 11.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.1 ESA04554.1 - 0.038 13.5 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESA04554.1 - 0.056 14.2 1.2 0.18 12.6 0.1 2.5 2 2 0 2 2 2 0 AAA domain Mg_chelatase PF01078.16 ESA04554.1 - 0.079 12.1 0.0 0.2 10.8 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Nup35_RRM_2 PF14605.1 ESA04555.1 - 0.029 14.1 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif p450 PF00067.17 ESA04558.1 - 9.2e-16 57.3 0.0 7.3e-11 41.2 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Spy1 PF11357.3 ESA04561.1 - 0.075 13.1 0.1 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Cell cycle regulatory protein NIL PF09383.5 ESA04563.1 - 0.12 11.9 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 NIL domain Nop14 PF04147.7 ESA04564.1 - 0.4 8.5 36.8 0.48 8.2 25.5 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 ESA04564.1 - 7.4 5.7 30.8 9.4 5.4 21.4 1.2 1 0 0 1 1 1 0 SDA1 Clathrin PF00637.15 ESA04566.1 - 1.8e-69 231.8 21.5 1.2e-35 122.2 3.8 3.5 4 0 0 4 4 4 2 Region in Clathrin and VPS DUF3294 PF07957.6 ESA04566.1 - 0.026 14.0 4.9 2.8 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3294) DUF1626 PF07788.6 ESA04566.1 - 0.045 13.5 0.2 5.7 6.8 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1626) CTNNBL PF08216.6 ESA04567.1 - 0.066 12.8 3.6 1.4 8.5 0.1 2.8 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear TLD PF07534.11 ESA04568.1 - 8.3e-16 58.2 3.2 1.1e-15 57.8 0.3 2.4 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA04568.1 - 1.5e-14 53.8 0.0 3.2e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04568.1 - 0.00047 19.9 2.0 0.0018 18.0 0.9 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3511 PF12023.3 ESA04568.1 - 0.12 11.7 1.3 0.29 10.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3511) DUF3458 PF11940.3 ESA04570.1 - 0.027 13.3 0.7 0.053 12.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3458) DUF2116 PF09889.4 ESA04571.1 - 0.13 12.0 3.4 0.22 11.3 2.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) RRM_6 PF14259.1 ESA04573.1 - 0.00026 20.9 0.0 0.0097 15.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA04573.1 - 0.00078 19.0 0.0 0.015 14.8 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA04573.1 - 0.015 15.1 0.1 0.046 13.5 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MENTAL PF10457.4 ESA04574.1 - 0.23 11.0 2.4 0.45 10.1 1.6 1.5 1 0 0 1 1 1 0 Cholesterol-capturing domain MBOAT_2 PF13813.1 ESA04575.1 - 3.8e-12 46.1 0.5 1.2e-11 44.5 0.4 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF3256 PF11644.3 ESA04576.1 - 0.081 12.4 0.1 0.081 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3256) Pkinase_Tyr PF07714.12 ESA04577.1 - 5.3e-50 169.9 0.0 6.7e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04577.1 - 2.7e-43 147.9 0.3 3.7e-43 147.5 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain HMG_box PF00505.14 ESA04578.1 - 7.9e-05 22.8 0.1 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box Kelch_5 PF13854.1 ESA04580.1 - 2.4e-24 84.8 0.1 4.1e-05 23.4 0.0 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA04580.1 - 1.2e-23 82.6 17.8 1.2e-05 25.3 0.1 8.0 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA04580.1 - 1.3e-23 82.5 10.6 7.2e-05 22.4 0.1 7.0 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA04580.1 - 2.7e-13 49.1 0.4 0.052 13.3 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA04580.1 - 4.9e-13 48.6 9.4 0.021 14.9 0.0 6.5 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESA04580.1 - 0.0016 17.9 14.7 0.12 11.9 0.0 5.6 6 1 0 6 6 6 2 Kelch motif Rax2 PF12768.2 ESA04580.1 - 0.0018 17.5 0.2 0.0061 15.8 0.0 2.1 2 1 0 2 2 2 1 Cortical protein marker for cell polarity SKG6 PF08693.5 ESA04580.1 - 0.003 16.8 0.2 0.0074 15.5 0.2 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF912 PF06024.7 ESA04580.1 - 0.0075 16.2 0.2 0.026 14.5 0.0 2.0 2 0 0 2 2 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 ESA04580.1 - 0.015 13.6 0.0 0.034 12.4 0.0 1.5 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Mid2 PF04478.7 ESA04580.1 - 0.055 12.8 0.0 0.18 11.1 0.0 1.9 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Glyoxal_oxid_N PF07250.6 ESA04580.1 - 0.066 12.2 0.0 0.23 10.4 0.0 1.9 2 0 0 2 2 2 0 Glyoxal oxidase N-terminus MAS20 PF02064.10 ESA04580.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor DUF1049 PF06305.6 ESA04580.1 - 0.097 12.1 0.0 0.36 10.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) TMEM154 PF15102.1 ESA04580.1 - 0.14 11.8 5.7 0.17 11.6 0.0 2.8 2 1 0 2 2 2 0 TMEM154 protein family Methyltransf_31 PF13847.1 ESA04581.1 - 0.57 9.7 4.8 0.41 10.2 0.7 2.0 2 0 0 2 2 2 0 Methyltransferase domain HMG_box PF00505.14 ESA04582.1 - 1.1e-06 28.8 0.1 1.1e-06 28.8 0.1 2.3 2 0 0 2 2 1 1 HMG (high mobility group) box UPF0564 PF10595.4 ESA04582.1 - 0.00039 19.4 20.4 0.00043 19.3 14.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 RR_TM4-6 PF06459.7 ESA04582.1 - 0.00062 19.7 11.3 0.00084 19.3 7.8 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 TFIIA PF03153.8 ESA04582.1 - 0.0012 18.7 17.4 0.0014 18.6 12.1 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 ESA04582.1 - 0.021 13.0 29.0 0.024 12.8 20.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SelP_N PF04592.9 ESA04582.1 - 0.031 13.6 16.0 0.054 12.8 11.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.17 ESA04582.1 - 0.052 12.5 9.7 0.077 11.9 6.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF605 PF04652.11 ESA04582.1 - 0.068 12.5 19.3 0.091 12.1 13.4 1.2 1 0 0 1 1 1 0 Vta1 like DUF4557 PF15101.1 ESA04582.1 - 0.072 12.9 17.5 0.18 11.5 12.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) RIC3 PF15361.1 ESA04582.1 - 0.082 13.1 12.2 0.19 11.9 8.4 1.7 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Suf PF05843.9 ESA04582.1 - 0.12 12.0 19.9 0.21 11.2 13.8 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FixO PF02433.10 ESA04582.1 - 0.12 11.7 6.2 0.21 10.9 4.3 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO Ndc1_Nup PF09531.5 ESA04582.1 - 0.21 9.9 10.0 0.24 9.7 6.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BAF1_ABF1 PF04684.8 ESA04582.1 - 0.23 10.2 36.6 0.48 9.2 25.4 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor UPF0560 PF10577.4 ESA04582.1 - 0.46 8.6 17.3 0.63 8.2 12.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MMR1 PF08505.5 ESA04582.1 - 0.48 10.4 20.7 0.13 12.2 11.9 1.8 2 1 1 3 3 2 0 Mitochondrial Myo2 receptor-related protein DUF3984 PF13136.1 ESA04582.1 - 0.86 8.7 19.4 1.3 8.1 13.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) FAM60A PF15396.1 ESA04582.1 - 1.3 8.7 13.9 2.3 7.8 9.6 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Spore_YhcN_YlaJ PF09580.5 ESA04582.1 - 1.5 8.9 13.7 2.8 8.0 9.5 1.6 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Neur_chan_memb PF02932.11 ESA04582.1 - 1.5 8.6 13.9 2.5 7.9 9.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paramyxo_ncap PF00973.14 ESA04582.1 - 1.8 7.1 11.3 0.51 8.9 6.0 1.4 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein CDC45 PF02724.9 ESA04582.1 - 2 6.3 15.2 2.6 5.9 10.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.1 ESA04582.1 - 2.5 7.2 17.8 0.57 9.4 10.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) FliP PF00813.15 ESA04582.1 - 2.9 7.5 6.2 8 6.1 4.3 1.8 1 0 0 1 1 1 0 FliP family Activator_LAG-3 PF11498.3 ESA04582.1 - 3 6.4 49.7 4.6 5.8 34.4 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CPSF100_C PF13299.1 ESA04582.1 - 3 7.9 14.1 5.8 7.0 9.8 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spore_coat_CotO PF14153.1 ESA04582.1 - 3 7.2 27.4 1.6 8.1 17.3 1.6 2 0 0 2 2 2 0 Spore coat protein CotO DUF3810 PF12725.2 ESA04582.1 - 3.2 6.5 11.0 5.2 5.8 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Lin-8 PF03353.10 ESA04582.1 - 4 6.6 22.2 7.3 5.7 15.4 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.4 ESA04582.1 - 6.4 4.9 19.1 1.8 6.7 11.1 1.6 2 0 0 2 2 2 0 Transmembrane protein RP-C_C PF11800.3 ESA04582.1 - 7.3 6.2 15.2 13 5.3 10.5 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region AUX_IAA PF02309.11 ESA04582.1 - 7.3 6.2 16.4 13 5.4 11.4 1.3 1 0 0 1 1 1 0 AUX/IAA family Rtf2 PF04641.7 ESA04582.1 - 7.6 5.6 19.0 13 4.8 13.2 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger SID-1_RNA_chan PF13965.1 ESA04582.1 - 9.9 4.1 10.7 14 3.7 7.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MFS_1 PF07690.11 ESA04583.1 - 3.3e-34 118.1 20.2 6.9e-30 103.9 11.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA04583.1 - 3.4e-10 39.1 16.0 1.3e-09 37.2 8.6 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter DUF4605 PF15378.1 ESA04583.1 - 0.47 10.1 4.3 2.7 7.7 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4605) Motile_Sperm PF00635.21 ESA04584.1 - 0.001 18.7 6.0 0.048 13.2 0.1 4.5 4 1 0 4 4 4 2 MSP (Major sperm protein) domain Exo_endo_phos PF03372.18 ESA04585.1 - 2.1e-11 44.2 2.2 3e-11 43.7 1.5 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA04585.1 - 5.4e-09 35.6 0.3 1e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Bap31 PF05529.7 ESA04587.1 - 3.8 6.9 6.3 7.3 5.9 4.3 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF693 PF05113.8 ESA04588.1 - 0.033 13.1 0.0 0.038 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF693) Vps39_2 PF10367.4 ESA04589.1 - 1.6e-33 115.1 2.0 5.2e-32 110.2 0.5 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 ESA04589.1 - 1.3e-09 37.8 10.9 3.4e-09 36.4 4.3 2.6 2 1 0 2 2 2 2 Region in Clathrin and VPS ABC_membrane_2 PF06472.10 ESA04590.1 - 1.1e-25 90.3 0.1 1.4e-25 89.9 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESA04590.1 - 1.1e-15 58.1 0.0 2.5e-15 56.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESA04590.1 - 0.00051 19.3 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESA04590.1 - 0.0021 18.3 0.7 0.0045 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESA04590.1 - 0.003 17.0 0.0 0.0074 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 ESA04590.1 - 0.0044 17.0 0.0 0.017 15.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA04590.1 - 0.015 15.2 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 ESA04590.1 - 0.06 13.0 0.0 13 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF761 PF05553.6 ESA04591.1 - 0.0062 15.8 0.3 15 5.0 0.0 4.0 4 0 0 4 4 4 2 Cotton fibre expressed protein DUF1122 PF06557.6 ESA04591.1 - 0.087 11.9 0.1 0.087 11.9 0.1 2.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1122) GDPD PF03009.12 ESA04592.1 - 6.4e-14 52.0 0.1 2.4e-13 50.1 0.1 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_4 PF13637.1 ESA04594.1 - 8.2e-05 23.0 0.1 0.022 15.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESA04594.1 - 0.00064 20.0 0.0 0.00093 19.4 0.0 1.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA04594.1 - 0.0009 19.2 0.0 0.43 10.9 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.25 ESA04594.1 - 0.041 13.6 0.0 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeat SPX PF03105.14 ESA04595.1 - 4.3e-19 69.3 5.6 7.7e-19 68.5 3.9 1.4 1 1 0 1 1 1 1 SPX domain F-box-like PF12937.2 ESA04596.1 - 0.042 13.5 0.2 0.12 12.1 0.1 1.9 1 0 0 1 1 1 0 F-box-like DNA_pol3_a_NI PF14480.1 ESA04597.1 - 0.026 14.1 1.3 0.034 13.7 0.3 1.5 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus I UDPGT PF00201.13 ESA04599.1 - 4.5e-19 68.3 0.0 1.4e-18 66.7 0.0 1.6 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA04599.1 - 3.7e-08 33.2 0.0 5.6e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA04599.1 - 7.7e-07 28.6 0.0 1.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 1 F-box-like PF12937.2 ESA04601.1 - 7.4e-08 31.9 1.0 2.7e-07 30.1 0.7 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA04601.1 - 0.063 12.9 4.8 0.25 11.0 0.6 3.8 3 1 0 3 3 3 0 F-box domain BTB PF00651.26 ESA04602.1 - 2.2e-12 46.9 1.3 1.3e-11 44.4 0.1 2.6 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA04602.1 - 4.1e-08 32.9 0.1 8.1e-06 25.6 0.0 2.9 1 1 1 2 2 2 2 BTB And C-terminal Kelch TLD PF07534.11 ESA04602.1 - 0.00074 19.5 0.1 0.0052 16.7 0.0 2.4 3 0 0 3 3 3 1 TLD Pkinase PF00069.20 ESA04603.1 - 1.4e-33 116.1 0.2 2.5e-33 115.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04603.1 - 4.1e-33 114.5 0.0 6.8e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04603.1 - 8.7e-06 25.6 0.1 1.9e-05 24.5 0.1 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA04603.1 - 0.0068 15.4 0.1 0.013 14.4 0.1 1.5 1 1 0 1 1 1 1 Kinase-like zinc-ribbons_6 PF07191.7 ESA04603.1 - 0.05 13.3 5.5 0.68 9.7 2.3 2.4 2 0 0 2 2 2 0 zinc-ribbons Kdo PF06293.9 ESA04603.1 - 0.054 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DYW_deaminase PF14432.1 ESA04603.1 - 0.083 12.8 0.6 0.2 11.6 0.5 1.6 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases TMEM240 PF15207.1 ESA04605.1 - 0.024 14.2 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 TMEM240 family AzlC PF03591.9 ESA04605.1 - 0.13 12.2 0.1 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 AzlC protein Prosystemin PF07376.6 ESA04606.1 - 0.081 12.2 1.3 0.097 12.0 0.9 1.1 1 0 0 1 1 1 0 Prosystemin AAA_23 PF13476.1 ESA04606.1 - 0.26 11.5 4.2 0.36 11.1 2.9 1.2 1 0 0 1 1 1 0 AAA domain TALPID3 PF15324.1 ESA04606.1 - 0.37 8.0 6.6 0.4 7.9 4.5 1.0 1 0 0 1 1 1 0 Hedgehog signalling target F-box-like PF12937.2 ESA04607.1 - 0.0051 16.5 0.8 0.012 15.3 0.1 2.0 2 0 0 2 2 2 1 F-box-like WSC PF01822.14 ESA04609.1 - 1.7e-06 27.8 10.5 2.7e-05 23.9 1.3 2.8 2 2 0 2 2 2 2 WSC domain TMEM154 PF15102.1 ESA04609.1 - 0.0023 17.6 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family EphA2_TM PF14575.1 ESA04609.1 - 0.0025 18.1 0.1 0.0061 16.9 0.1 1.7 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.1 ESA04609.1 - 0.029 14.0 0.1 0.053 13.1 0.1 1.4 1 0 0 1 1 1 0 FAM176 family SKG6 PF08693.5 ESA04609.1 - 0.031 13.6 6.3 0.055 12.7 4.4 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Chordopox_A13L PF05961.6 ESA04609.1 - 0.041 13.8 0.7 0.078 12.9 0.5 1.4 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Protocadherin PF08374.6 ESA04609.1 - 0.051 13.2 0.1 0.08 12.5 0.1 1.3 1 0 0 1 1 1 0 Protocadherin DUF3827 PF12877.2 ESA04609.1 - 0.097 10.7 0.9 0.13 10.3 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF1191 PF06697.7 ESA04609.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Neur_chan_memb PF02932.11 ESA04609.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region stn_TNFRSF12A PF12191.3 ESA04609.1 - 0.31 11.0 1.8 1.1 9.3 1.3 1.9 1 1 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PAN_3 PF08277.7 ESA04609.1 - 7.4 6.2 8.5 1.4 8.5 0.5 3.2 3 1 1 4 4 4 0 PAN-like domain SWIRM PF04433.12 ESA04610.1 - 1e-08 35.1 0.0 2.2e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain DUF1370 PF07114.6 ESA04610.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1370) DUF3585 PF12130.3 ESA04611.1 - 0.0026 17.6 6.8 0.35 10.7 1.5 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3585) NBP1 PF08537.5 ESA04611.1 - 0.13 11.4 3.8 0.12 11.6 2.1 1.4 1 1 0 1 1 1 0 Fungal Nap binding protein NBP1 NYD-SP28_assoc PF14775.1 ESA04611.1 - 0.32 10.7 4.8 1.2 8.8 0.1 3.2 2 2 0 3 3 3 0 Sperm tail C-terminal domain DUF3958 PF13125.1 ESA04611.1 - 0.95 9.3 4.1 6 6.8 0.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3958) ToxN_toxin PF13958.1 ESA04611.1 - 2.2 7.9 7.6 2.4 7.8 0.5 2.1 1 1 1 2 2 2 0 Toxin ToxN, type III toxin-antitoxin system GAGA_bind PF06217.7 ESA04611.1 - 4.5 7.1 6.7 13 5.6 4.2 1.8 1 1 1 2 2 2 0 GAGA binding protein-like family DUF2204 PF09970.4 ESA04611.1 - 6 6.2 11.0 28 4.1 7.6 1.8 1 1 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) GAGA_bind PF06217.7 ESA04612.1 - 0.0038 17.2 12.9 0.0071 16.3 1.7 2.6 1 1 1 2 2 2 2 GAGA binding protein-like family CALCOCO1 PF07888.6 ESA04612.1 - 0.1 10.8 13.7 0.033 12.5 7.7 1.3 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Zwint PF15556.1 ESA04612.1 - 0.37 10.0 7.0 0.75 9.0 4.6 1.7 1 1 0 1 1 1 0 ZW10 interactor CCDC155 PF14662.1 ESA04612.1 - 1.3 8.5 18.6 5.8 6.4 3.6 3.1 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 GAGA_bind PF06217.7 ESA04614.1 - 0.16 11.9 0.8 0.15 11.9 0.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family GAGA_bind PF06217.7 ESA04615.1 - 0.0034 17.4 3.2 0.0039 17.2 2.2 1.1 1 0 0 1 1 1 1 GAGA binding protein-like family DUF3552 PF12072.3 ESA04615.1 - 0.017 14.3 2.2 0.021 14.0 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF536 PF04394.9 ESA04615.1 - 0.05 13.3 5.6 3.6 7.4 0.4 3.1 1 1 2 3 3 3 0 Protein of unknown function, DUF536 PTEN_C2 PF10409.4 ESA04615.1 - 1.4 8.6 5.9 2.1 8.0 4.1 1.4 1 1 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein DUF4218 PF13960.1 ESA04616.1 - 5.3e-05 22.6 0.1 7.1e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) KRTDAP PF15200.1 ESA04616.1 - 0.0076 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Keratinocyte differentiation-associated DUF2236 PF09995.4 ESA04616.1 - 0.049 12.9 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2236) RAMP4 PF06624.7 ESA04618.1 - 0.052 13.0 0.2 1 8.9 0.0 2.2 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 zf-CW PF07496.10 ESA04620.1 - 0.023 14.4 1.3 0.74 9.5 0.2 3.0 2 1 0 2 2 2 0 CW-type Zinc Finger DUF1510 PF07423.6 ESA04620.1 - 0.36 10.1 3.6 0.5 9.7 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SDA1 PF05285.7 ESA04620.1 - 3.3 6.9 8.8 4.3 6.5 6.1 1.1 1 0 0 1 1 1 0 SDA1 Pkinase_Tyr PF07714.12 ESA04627.1 - 4.2e-21 75.2 0.0 6.6e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04627.1 - 4.6e-17 62.0 1.7 4.6e-17 62.0 1.2 2.1 2 1 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA04627.1 - 0.055 13.1 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA04628.1 - 2.1e-22 79.4 0.0 3.1e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04628.1 - 1.3e-20 73.6 1.6 2.6e-20 72.6 0.1 2.1 2 1 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA04628.1 - 0.0047 16.0 0.0 0.0079 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA04628.1 - 0.015 15.0 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RE_HindVP PF09519.5 ESA04628.1 - 0.02 13.8 0.1 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 HindVP restriction endonuclease DUF2977 PF11192.3 ESA04630.1 - 0.11 12.3 1.3 4.3 7.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2977) DUF2816 PF10992.3 ESA04630.1 - 0.22 11.1 5.9 3.6 7.2 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2816) Pkinase_Tyr PF07714.12 ESA04634.1 - 1.1e-44 152.5 0.0 1.4e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04634.1 - 1.3e-37 129.3 0.0 2e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Dimer_Tnp_hAT PF05699.9 ESA04635.1 - 0.044 13.4 0.1 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA04636.1 - 3.4e-06 26.6 0.0 7.6e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF659 PF04937.10 ESA04637.1 - 5.9e-05 22.6 0.1 8.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) PIF1 PF05970.9 ESA04638.1 - 1.4e-11 43.9 0.0 8e-06 25.0 0.0 2.1 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 ESA04638.1 - 1.2e-06 28.2 0.0 0.00013 21.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA04638.1 - 4e-06 26.4 0.0 6.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 ESA04638.1 - 0.00093 18.8 0.0 0.087 12.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain IIGP PF05049.8 ESA04638.1 - 0.0066 15.3 0.0 0.0089 14.8 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) DUF258 PF03193.11 ESA04638.1 - 0.0079 15.3 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA04638.1 - 0.029 14.6 0.0 0.045 14.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 ESA04638.1 - 0.033 15.0 0.0 0.046 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESA04638.1 - 0.04 13.7 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF2075 PF09848.4 ESA04638.1 - 0.053 12.4 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Torsin PF06309.6 ESA04638.1 - 0.088 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Torsin PhoH PF02562.11 ESA04638.1 - 0.088 12.0 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.16 ESA04638.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 ESA04638.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESA04638.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Borrelia_REV PF03978.8 ESA04643.1 - 2.4 7.8 4.9 38 3.9 0.2 2.9 2 1 1 3 3 3 0 Borrelia burgdorferi REV protein gp32 PF08804.5 ESA04646.1 - 0.11 12.6 0.3 16 5.7 0.0 2.4 2 0 0 2 2 2 0 gp32 DNA binding protein like RRM_1 PF00076.17 ESA04647.1 - 1.6e-05 24.4 0.0 3.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA04647.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA04647.1 - 0.071 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Lum_binding PF00677.12 ESA04647.1 - 0.097 12.5 0.0 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 Lumazine binding domain DUF2431 PF10354.4 ESA04648.1 - 5.3e-49 166.3 0.5 8.5e-49 165.7 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Actin PF00022.14 ESA04649.1 - 3.4e-63 213.4 0.0 3.2e-33 114.7 0.0 2.2 2 0 0 2 2 2 2 Actin UPF0172 PF03665.8 ESA04649.1 - 2.6 7.5 6.0 1.8 8.0 1.8 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) CIMR PF00878.13 ESA04650.1 - 4.6e-19 68.6 1.6 1.4e-08 34.6 0.2 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Man-6-P_recep PF02157.10 ESA04650.1 - 2.1e-10 40.1 0.0 3.2e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.5 ESA04650.1 - 1.7e-09 37.3 1.3 1.7e-09 37.3 0.9 2.0 2 1 0 2 2 2 1 Autophagy-related protein 27 PRKCSH_1 PF13015.1 ESA04650.1 - 0.02 14.3 0.1 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein YqzM PF14141.1 ESA04650.1 - 0.061 13.1 3.8 0.16 11.7 2.7 1.7 1 0 0 1 1 1 0 YqzM-like protein zf-DHHC PF01529.15 ESA04650.1 - 0.062 12.7 0.1 0.14 11.5 0.1 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase Sigma_reg_N PF13800.1 ESA04650.1 - 0.14 12.2 0.3 6.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Pox_A14 PF05767.7 ESA04650.1 - 0.15 12.0 1.5 12 5.9 0.0 3.1 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Mnd1 PF03962.10 ESA04651.1 - 7.4e-59 198.5 2.9 8.2e-59 198.4 2.0 1.0 1 0 0 1 1 1 1 Mnd1 family GMP_PDE_delta PF05351.6 ESA04651.1 - 0.0042 16.9 0.4 0.0072 16.1 0.1 1.5 2 0 0 2 2 2 1 GMP-PDE, delta subunit Takusan PF04822.8 ESA04651.1 - 0.0072 16.0 1.2 0.011 15.4 0.8 1.4 1 0 0 1 1 1 1 Takusan TBPIP PF07106.8 ESA04651.1 - 0.011 15.2 1.6 0.016 14.7 1.1 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TFIIE_alpha PF02002.12 ESA04651.1 - 0.017 14.6 0.3 0.034 13.6 0.2 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit DivIC PF04977.10 ESA04651.1 - 0.022 14.2 7.9 0.033 13.6 1.9 2.3 1 1 1 2 2 2 0 Septum formation initiator bZIP_2 PF07716.10 ESA04651.1 - 0.023 14.5 3.7 0.023 14.5 2.6 2.3 2 0 0 2 2 2 0 Basic region leucine zipper DUF773 PF05600.7 ESA04651.1 - 0.034 12.9 1.3 0.045 12.5 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Atg14 PF10186.4 ESA04651.1 - 0.05 12.5 0.8 0.061 12.2 0.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 ESA04651.1 - 0.058 11.8 0.7 0.065 11.6 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TMF_TATA_bd PF12325.3 ESA04651.1 - 0.15 11.7 3.9 0.23 11.2 0.8 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Viral_P18 PF04521.8 ESA04651.1 - 0.41 10.1 6.2 0.12 11.8 1.9 2.0 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein DUF904 PF06005.7 ESA04651.1 - 0.79 10.0 8.5 3.2 8.0 5.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF904) CENP-Q PF13094.1 ESA04651.1 - 1 9.3 7.1 0.56 10.2 3.7 1.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ADIP PF11559.3 ESA04651.1 - 1.3 8.9 7.3 0.66 9.8 3.4 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TSC22 PF01166.13 ESA04651.1 - 2.4 8.1 8.0 6.3 6.8 0.8 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family NYD-SP28_assoc PF14775.1 ESA04651.1 - 4.2 7.1 7.6 3.4 7.4 1.3 2.4 2 0 0 2 2 2 0 Sperm tail C-terminal domain Cullin PF00888.17 ESA04652.1 - 4.7e-168 560.3 14.4 6.5e-168 559.9 10.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESA04652.1 - 4e-28 97.0 3.3 8.1e-27 92.8 1.4 2.9 2 0 0 2 2 2 1 Cullin protein neddylation domain HbrB PF08539.6 ESA04652.1 - 3.5e-06 26.9 0.2 1.1e-05 25.3 0.2 1.9 1 0 0 1 1 1 1 HbrB-like Ribonucleas_3_3 PF14622.1 ESA04653.1 - 8.8e-21 74.1 0.1 1.3e-19 70.4 0.0 2.4 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 ESA04653.1 - 1.4e-10 41.5 0.2 5.7e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.20 ESA04653.1 - 2.8e-07 31.0 0.0 5.4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif RabGAP-TBC PF00566.13 ESA04654.1 - 2.8e-30 105.3 2.0 3.7e-30 105.0 0.3 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TFIIS_C PF01096.13 ESA04657.1 - 2.7e-17 62.1 1.1 2.7e-17 62.1 0.7 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.2 ESA04657.1 - 2.7e-05 23.8 7.7 0.017 14.9 0.1 2.9 2 1 0 2 2 2 2 Double zinc ribbon zf-ribbon_3 PF13248.1 ESA04657.1 - 8.5e-05 21.6 14.9 0.21 10.8 0.2 4.1 3 1 0 3 3 3 2 zinc-ribbon domain RNA_POL_M_15KD PF02150.11 ESA04657.1 - 0.0002 20.9 10.9 0.00029 20.4 0.3 3.1 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit zf-RING_3 PF14369.1 ESA04657.1 - 0.00028 20.8 4.7 0.85 9.6 0.1 3.3 3 0 0 3 3 3 1 zinc-finger Lar_restr_allev PF14354.1 ESA04657.1 - 0.00045 20.4 7.7 0.0049 17.1 0.4 2.9 2 1 0 2 2 2 1 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.5 ESA04657.1 - 0.002 18.0 10.4 1.2 9.1 0.3 3.9 3 1 1 4 4 4 1 Zinc ribbon domain Terminase_GpA PF05876.7 ESA04657.1 - 0.0025 16.2 0.7 0.0027 16.1 0.5 1.2 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) zf-H2C2_2 PF13465.1 ESA04657.1 - 0.0042 17.3 1.8 0.37 11.1 0.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain HypA PF01155.14 ESA04657.1 - 0.0042 16.7 5.6 0.59 9.8 0.1 2.8 2 1 0 2 2 2 1 Hydrogenase expression/synthesis hypA family DUF2387 PF09526.5 ESA04657.1 - 0.0049 16.7 2.9 1.2 9.1 0.3 2.4 2 0 0 2 2 2 2 Probable metal-binding protein (DUF2387) zf-TFIIB PF13453.1 ESA04657.1 - 0.0088 15.2 1.5 0.0088 15.2 1.0 2.4 3 0 0 3 3 2 1 Transcription factor zinc-finger zinc_ribbon_5 PF13719.1 ESA04657.1 - 0.015 14.8 8.6 0.93 9.1 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-ISL3 PF14690.1 ESA04657.1 - 0.018 15.0 9.1 3.2 7.8 0.1 3.6 4 0 0 4 4 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 OrfB_Zn_ribbon PF07282.6 ESA04657.1 - 0.019 14.6 8.7 0.6 9.8 0.2 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-DNA_Pol PF08996.5 ESA04657.1 - 0.019 14.3 1.1 0.019 14.3 0.8 1.9 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Zn_Tnp_IS1595 PF12760.2 ESA04657.1 - 0.02 14.7 9.2 0.55 10.0 3.1 3.1 2 2 0 2 2 2 0 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.1 ESA04657.1 - 0.023 14.9 8.1 0.91 9.8 0.9 2.6 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_4 PF13717.1 ESA04657.1 - 0.025 14.2 9.3 1.2 8.9 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain TerY-C PF15616.1 ESA04657.1 - 0.037 13.9 6.2 0.27 11.1 1.2 2.3 2 1 0 2 2 2 0 TerY-C metal binding domain RRN7 PF11781.3 ESA04657.1 - 0.052 13.0 9.0 5.1 6.6 0.1 3.4 2 1 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Prok-RING_1 PF14446.1 ESA04657.1 - 0.055 13.2 8.3 1.1 9.0 0.9 3.4 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 PhnA_Zn_Ribbon PF08274.7 ESA04657.1 - 0.057 13.2 0.8 0.057 13.2 0.6 2.4 2 1 0 2 2 1 0 PhnA Zinc-Ribbon TF_Zn_Ribbon PF08271.7 ESA04657.1 - 0.061 12.6 12.6 0.35 10.2 4.2 3.6 3 1 0 3 3 3 0 TFIIB zinc-binding zf-CSL PF05207.8 ESA04657.1 - 0.066 12.7 0.1 0.066 12.7 0.1 3.2 2 2 1 3 3 3 0 CSL zinc finger zinc_ribbon_2 PF13240.1 ESA04657.1 - 0.069 12.6 17.5 0.67 9.5 0.2 3.6 3 1 0 3 3 3 0 zinc-ribbon domain Rad50_zn_hook PF04423.9 ESA04657.1 - 0.075 12.5 2.1 0.81 9.2 0.3 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif NOB1_Zn_bind PF08772.6 ESA04657.1 - 0.076 12.8 9.5 0.97 9.3 0.1 4.0 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like DUF2072 PF09845.4 ESA04657.1 - 0.089 12.7 6.6 0.11 12.3 0.1 2.9 2 1 1 3 3 3 0 Zn-ribbon containing protein (DUF2072) zf-FPG_IleRS PF06827.9 ESA04657.1 - 0.17 11.5 6.7 3.3 7.4 0.6 3.3 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS Baculo_LEF5_C PF11792.3 ESA04657.1 - 0.2 11.0 2.5 0.39 10.1 0.1 2.6 2 1 1 3 3 2 0 Baculoviridae late expression factor 5 C-terminal domain C1_2 PF03107.11 ESA04657.1 - 0.22 11.6 2.0 0.82 9.8 0.1 2.5 2 0 0 2 2 2 0 C1 domain UPF0547 PF10571.4 ESA04657.1 - 0.23 11.1 15.2 0.32 10.7 0.9 3.3 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-C3HC4_4 PF15227.1 ESA04657.1 - 0.35 10.7 6.3 1.3 8.9 0.2 3.1 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING DUF2321 PF10083.4 ESA04657.1 - 0.35 10.3 4.2 5.4 6.4 0.3 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Mu-like_Com PF10122.4 ESA04657.1 - 0.41 9.7 2.9 11 5.1 0.1 2.9 3 0 0 3 3 3 0 Mu-like prophage protein Com Cys_rich_CPCC PF14206.1 ESA04657.1 - 0.53 9.8 5.5 14 5.2 0.1 3.1 3 0 0 3 3 3 0 Cysteine-rich CPCC GFA PF04828.9 ESA04657.1 - 0.56 10.1 9.1 7.6 6.5 0.3 3.2 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme DUF35_N PF12172.3 ESA04657.1 - 0.69 9.8 5.6 14 5.7 0.0 3.0 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-IS66 PF13005.2 ESA04657.1 - 0.76 9.7 8.7 9.4 6.2 0.1 3.3 3 0 0 3 3 3 0 zinc-finger binding domain of transposase IS66 Trm112p PF03966.11 ESA04657.1 - 0.77 10.1 4.7 5.2 7.5 1.7 3.0 2 1 0 2 2 2 0 Trm112p-like protein CpXC PF14353.1 ESA04657.1 - 0.79 9.6 10.1 1.9 8.4 2.3 3.4 3 1 0 3 3 2 0 CpXC protein Cys_rich_KTR PF14205.1 ESA04657.1 - 0.93 8.9 8.0 13 5.3 0.0 3.6 3 1 1 4 4 3 0 Cysteine-rich KTR C1_1 PF00130.17 ESA04657.1 - 1 9.1 5.7 0.71 9.6 0.2 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rpr2 PF04032.11 ESA04657.1 - 1.1 9.2 9.2 1.8e+02 2.0 6.4 2.7 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Elf1 PF05129.8 ESA04657.1 - 1.1 9.0 11.0 0.86 9.3 2.0 3.3 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like IBR PF01485.16 ESA04657.1 - 1.6 8.6 9.1 2.9 7.8 2.4 2.7 2 1 0 2 2 2 0 IBR domain Nudix_N_2 PF14803.1 ESA04657.1 - 1.7 8.4 11.4 4.7 6.9 0.3 3.6 4 0 0 4 4 3 0 Nudix N-terminal DUF2296 PF10058.4 ESA04657.1 - 2 8.1 9.7 2.2 8.0 0.0 3.2 4 0 0 4 4 3 0 Predicted integral membrane metal-binding protein (DUF2296) DNA_RNApol_7kD PF03604.8 ESA04657.1 - 2.1 7.8 11.9 6.4 6.3 0.1 3.8 3 1 1 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit Cys_rich_CPXG PF14255.1 ESA04657.1 - 3.6 7.4 6.0 73 3.3 4.2 2.6 1 1 0 1 1 1 0 Cysteine-rich CPXCG GATA PF00320.22 ESA04657.1 - 3.8 6.9 9.0 0.78 9.1 0.1 3.1 2 2 1 3 3 2 0 GATA zinc finger DUF3797 PF12677.2 ESA04657.1 - 4.4 7.0 12.3 0.9 9.2 1.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) zf-C2H2_4 PF13894.1 ESA04657.1 - 4.4 7.8 8.9 6.4 7.3 0.5 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger DUF2318 PF10080.4 ESA04657.1 - 4.5 7.1 5.8 4.6 7.0 0.4 2.6 1 1 2 3 3 3 0 Predicted membrane protein (DUF2318) Auto_anti-p27 PF06677.7 ESA04657.1 - 5.1 6.9 12.6 12 5.7 0.7 3.2 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) A2L_zn_ribbon PF08792.5 ESA04657.1 - 5.4 6.5 9.6 4.1 6.9 0.4 3.1 3 0 0 3 3 3 0 A2L zinc ribbon domain RNHCP PF12647.2 ESA04657.1 - 6.3 6.7 10.2 13 5.6 1.6 3.4 2 2 1 3 3 3 0 RNHCP domain zf-RING_4 PF14570.1 ESA04657.1 - 6.8 6.3 7.5 25 4.5 0.1 3.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-tcix PF14952.1 ESA04657.1 - 7.3 6.0 9.8 5.8 6.3 0.1 3.3 3 0 0 3 3 3 0 Putative treble-clef, zinc-finger, Zn-binding zf-Sec23_Sec24 PF04810.10 ESA04657.1 - 7.9 6.1 8.4 3.8 7.1 0.1 3.3 4 0 0 4 4 3 0 Sec23/Sec24 zinc finger DnaJ_CXXCXGXG PF00684.14 ESA04657.1 - 8.2 6.5 7.8 28 4.8 0.2 2.6 2 1 0 2 2 2 0 DnaJ central domain zf-NADH-PPase PF09297.6 ESA04657.1 - 9.5 5.8 13.9 1.9 8.0 0.3 3.5 4 0 0 4 4 3 0 NADH pyrophosphatase zinc ribbon domain His_Phos_1 PF00300.17 ESA04658.1 - 1.2e-30 106.6 0.1 2e-30 105.9 0.1 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Toxin_R_bind_N PF07953.7 ESA04659.1 - 0.085 12.3 0.4 0.11 11.9 0.3 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, N-terminal receptor binding DUF4611 PF15387.1 ESA04660.1 - 4.7 7.4 9.5 8.2 6.6 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) MIS13 PF08202.6 ESA04661.1 - 0.0082 15.2 6.9 0.0094 15.0 4.8 1.1 1 0 0 1 1 1 1 Mis12-Mtw1 protein family COG2 PF06148.6 ESA04661.1 - 0.021 14.6 0.5 0.037 13.8 0.3 1.4 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 bZIP_1 PF00170.16 ESA04661.1 - 0.027 14.4 0.4 0.057 13.3 0.2 1.6 1 0 0 1 1 1 0 bZIP transcription factor DUF3166 PF11365.3 ESA04661.1 - 0.036 14.5 0.1 0.071 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3166) DUF3643 PF12356.3 ESA04661.1 - 0.14 11.4 2.3 0.26 10.6 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3643) ATG16 PF08614.6 ESA04661.1 - 0.42 10.4 8.7 0.63 9.8 6.0 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF506 PF04720.7 ESA04661.1 - 1.8 8.1 9.4 2.4 7.7 6.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF506) Pox_A32 PF04665.7 ESA04662.1 - 1e-08 34.8 0.1 1.7e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein Lipoprotein_21 PF14041.1 ESA04662.1 - 0.15 11.9 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 LppP/LprE lipoprotein DUF953 PF06110.6 ESA04662.1 - 0.28 10.6 5.8 4.3 6.8 0.4 2.5 1 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) DUF3799 PF12684.2 ESA04665.1 - 0.079 12.2 1.1 8.2 5.7 0.1 2.2 2 0 0 2 2 2 0 PDDEXK-like domain of unknown function (DUF3799) DUF3590 PF12148.3 ESA04665.1 - 0.1 12.2 1.0 12 5.5 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3590) DUF4414 PF14377.1 ESA04665.1 - 0.55 10.1 10.1 3.2 7.6 2.2 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4414) LRR_7 PF13504.1 ESA04667.1 - 0.027 14.6 1.5 13 6.4 0.1 5.3 4 1 0 4 4 4 0 Leucine rich repeat RIO1 PF01163.17 ESA04668.1 - 5.9e-11 42.0 0.2 6.3e-11 41.9 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Sel1 PF08238.7 ESA04670.1 - 7.4e-199 639.8 110.9 1.9e-13 50.5 0.4 18.3 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA04670.1 - 1.5e-10 40.8 57.3 0.12 12.8 0.1 15.2 15 1 0 15 15 15 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA04670.1 - 4e-08 32.8 53.7 4.1 7.8 0.1 17.9 15 2 3 18 18 18 3 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA04670.1 - 7.6e-05 22.5 0.0 14 5.2 0.0 6.1 2 1 3 5 5 5 1 Caspase domain MIT PF04212.13 ESA04670.1 - 0.016 15.0 91.2 3.2 7.6 0.5 16.8 14 3 3 17 17 17 0 MIT (microtubule interacting and transport) domain Glu_syn_central PF04898.9 ESA04670.1 - 0.085 12.1 16.5 2.5 7.2 0.1 7.6 5 3 2 8 8 8 0 Glutamate synthase central domain DUF424 PF04242.8 ESA04670.1 - 0.46 10.5 10.9 5.7 7.0 0.1 6.6 6 4 1 7 7 7 0 Protein of unknown function (DUF424) Pkinase_Tyr PF07714.12 ESA04671.1 - 5.1e-07 29.0 0.0 7.8e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04671.1 - 0.033 13.3 0.0 0.068 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.20 ESA04672.1 - 7.1e-25 87.6 4.8 1e-23 83.8 0.2 2.8 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04672.1 - 3.4e-24 85.3 0.2 1.5e-19 70.0 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase APH PF01636.18 ESA04672.1 - 0.00034 20.4 0.0 0.00054 19.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4634 PF15465.1 ESA04673.1 - 0.062 13.5 0.9 0.11 12.7 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) DUF547 PF04784.9 ESA04673.1 - 0.081 12.8 0.1 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF547 Pkinase_Tyr PF07714.12 ESA04674.1 - 4.8e-15 55.3 0.1 3.2e-14 52.6 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04674.1 - 2.2e-08 33.5 0.1 9.9e-08 31.4 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain IMCp PF12314.3 ESA04674.1 - 0.0019 18.3 0.4 0.004 17.2 0.3 1.5 1 0 0 1 1 1 1 Inner membrane complex protein Histone PF00125.19 ESA04675.1 - 5.3e-24 84.1 0.0 7.2e-24 83.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA04675.1 - 0.00039 20.4 0.0 0.0006 19.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Peptidase_C12 PF01088.16 ESA04676.1 - 4.7e-52 176.2 0.0 1e-51 175.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 ALIX_LYPXL_bnd PF13949.1 ESA04676.1 - 0.022 13.7 7.4 0.036 13.0 5.1 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV ANTH PF07651.11 ESA04676.1 - 0.035 12.8 0.0 0.058 12.0 0.0 1.3 1 0 0 1 1 1 0 ANTH domain V_ATPase_I PF01496.14 ESA04676.1 - 2.5 5.8 5.7 3.3 5.4 3.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BTB PF00651.26 ESA04677.1 - 1.3e-17 63.7 0.1 1.3e-17 63.7 0.1 2.1 2 1 1 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA04677.1 - 9e-14 51.6 1.3 3.3e-13 49.8 0.9 2.0 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA04677.1 - 3.3e-08 33.2 3.0 7.4e-08 32.1 0.4 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA04677.1 - 0.021 13.9 0.4 0.05 12.7 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3342) DUF3405 PF11885.3 ESA04678.1 - 0.038 12.2 0.2 0.045 11.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) DUF677 PF05055.7 ESA04678.1 - 0.056 12.1 4.1 0.066 11.8 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF677) SNF2_N PF00176.18 ESA04680.1 - 1.3e-70 237.5 0.7 1.3e-70 237.5 0.5 3.2 3 1 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESA04680.1 - 2.7e-16 59.2 0.1 1e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 ESA04680.1 - 2.5e-09 36.3 0.7 2.5e-09 36.3 0.5 3.5 2 2 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 ESA04680.1 - 3.7e-06 26.5 0.1 3.5e-05 23.3 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_14 PF13173.1 ESA04680.1 - 0.031 14.1 2.6 2.8 7.8 0.1 3.6 4 0 0 4 4 4 0 AAA domain Fra10Ac1 PF09725.4 ESA04681.1 - 6.6e-50 168.1 8.0 6.6e-50 168.1 5.6 1.9 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 Prog_receptor PF02161.10 ESA04681.1 - 0.17 10.6 0.6 0.22 10.3 0.4 1.1 1 0 0 1 1 1 0 Progesterone receptor zf-3CxxC PF13695.1 ESA04681.1 - 0.2 11.9 9.6 0.036 14.2 4.0 1.7 2 0 0 2 2 2 0 Zinc-binding domain TIM21 PF08294.6 ESA04682.1 - 1.3e-32 112.4 0.1 1.8e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.5 ESA04682.1 - 0.00016 21.1 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 ABC2_membrane_3 PF12698.2 ESA04683.1 - 0.67 8.9 3.4 0.71 8.8 2.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein FBD PF08387.5 ESA04684.1 - 0.0081 15.5 0.4 0.024 14.1 0.3 1.7 1 0 0 1 1 1 1 FBD TPR_11 PF13414.1 ESA04684.1 - 0.11 12.1 0.1 0.33 10.6 0.1 1.8 1 0 0 1 1 1 0 TPR repeat Cation_efflux PF01545.16 ESA04685.1 - 1.6e-34 119.3 8.3 2e-34 118.9 5.7 1.1 1 0 0 1 1 1 1 Cation efflux family Suf PF05843.9 ESA04686.1 - 4.5e-06 26.5 16.1 4.8e-05 23.2 0.1 4.1 1 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_16 PF13432.1 ESA04686.1 - 7.8e-05 23.2 0.0 0.27 11.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA04686.1 - 0.00028 21.2 0.0 46 5.0 0.0 6.2 5 2 2 7 7 7 0 Tetratricopeptide repeat FAT PF02259.18 ESA04686.1 - 0.0018 17.2 0.1 0.014 14.4 0.0 2.1 2 0 0 2 2 2 1 FAT domain TPR_19 PF14559.1 ESA04686.1 - 0.12 12.7 0.0 38 4.7 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 ESA04686.1 - 0.95 9.2 6.5 0.47 10.2 0.4 3.4 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 PP2C PF00481.16 ESA04687.1 - 8.3e-71 238.3 0.0 9.3e-71 238.2 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESA04687.1 - 4.4e-05 22.9 0.0 6.7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C zf-DHHC PF01529.15 ESA04688.1 - 5.5e-43 146.3 5.1 5.5e-43 146.3 3.6 1.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase PSI PF01437.20 ESA04688.1 - 0.012 15.7 8.8 0.026 14.6 6.1 1.5 1 0 0 1 1 1 0 Plexin repeat DUF4131 PF13567.1 ESA04688.1 - 0.22 10.9 4.3 10 5.4 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF2339 PF10101.4 ESA04688.1 - 0.58 8.3 8.8 0.048 11.9 1.3 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) Colicin_V PF02674.11 ESA04688.1 - 0.61 9.9 9.2 0.45 10.3 2.5 2.2 2 0 0 2 2 2 0 Colicin V production protein DUF202 PF02656.10 ESA04688.1 - 9.9 6.4 8.1 0.64 10.2 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF202) CBFD_NFYB_HMF PF00808.18 ESA04689.1 - 1.9e-18 66.2 1.5 3e-18 65.6 1.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF3510 PF12022.3 ESA04689.1 - 0.024 14.7 1.1 0.035 14.2 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) Bromo_TP PF07524.8 ESA04689.1 - 0.027 14.1 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 ESA04689.1 - 0.059 13.4 0.3 0.11 12.6 0.2 1.6 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF3753 PF12575.3 ESA04689.1 - 0.11 12.3 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Pkinase PF00069.20 ESA04691.1 - 1e-30 106.7 0.0 1.2e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04691.1 - 2.2e-27 95.7 0.0 2.4e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04691.1 - 0.025 14.2 0.2 0.039 13.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDE_1 PF03184.14 ESA04692.1 - 8.4e-12 44.6 0.0 9e-12 44.5 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Phage_Mu_Gam PF07352.7 ESA04693.1 - 0.0099 15.4 0.3 0.013 15.0 0.2 1.2 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF2315 PF10231.4 ESA04693.1 - 0.046 13.5 0.4 0.079 12.8 0.2 1.6 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) FAR1 PF03101.10 ESA04694.1 - 5.2e-09 36.5 3.9 7.9e-09 35.9 2.7 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain MULE PF10551.4 ESA04695.1 - 3.7e-07 30.2 0.1 1.3e-05 25.2 0.0 2.3 2 0 0 2 2 2 1 MULE transposase domain Scm3 PF10384.4 ESA04695.1 - 0.062 12.8 1.0 0.25 10.8 0.2 2.1 2 0 0 2 2 2 0 Centromere protein Scm3 AAA_15 PF13175.1 ESA04695.1 - 0.27 10.2 1.8 0.38 9.7 1.3 1.1 1 0 0 1 1 1 0 AAA ATPase domain Kelch_6 PF13964.1 ESA04696.1 - 0.0028 17.7 6.5 0.35 11.1 0.2 4.1 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.1 ESA04696.1 - 0.021 14.5 1.2 8.9 6.1 0.1 3.3 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA04696.1 - 0.19 11.9 8.1 5 7.4 0.7 3.9 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA04696.1 - 1.8 8.1 8.6 0.45 10.0 0.5 3.1 2 1 1 3 3 3 0 Kelch motif Herpes_UL87 PF03043.9 ESA04699.1 - 0.027 12.8 0.0 0.037 12.4 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family DUF1877 PF08974.5 ESA04699.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Sel1 PF08238.7 ESA04702.1 - 0 1179.7 221.0 1.3e-13 51.0 1.0 38.2 37 1 1 38 38 38 37 Sel1 repeat TPR_6 PF13174.1 ESA04702.1 - 5.8e-30 101.6 108.8 0.22 12.0 0.1 29.9 30 1 1 31 31 31 16 Tetratricopeptide repeat TPR_16 PF13432.1 ESA04702.1 - 1.6e-08 34.9 61.4 1.8 9.3 0.3 20.0 15 6 8 23 23 23 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA04702.1 - 0.063 13.2 0.2 1.3e+02 2.6 0.0 6.4 8 1 1 9 9 9 0 Influenza Matrix protein (M1) C-terminal domain IDO PF01231.13 ESA04703.1 - 9.4e-55 185.7 0.0 1.3e-54 185.3 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Sel1 PF08238.7 ESA04704.1 - 0 1541.2 258.4 2.7e-12 46.8 0.7 48.4 47 2 2 49 49 49 47 Sel1 repeat TPR_6 PF13174.1 ESA04704.1 - 6.2e-22 76.5 141.6 0.26 11.8 0.0 37.0 40 0 0 40 40 40 14 Tetratricopeptide repeat DUF2530 PF10745.4 ESA04704.1 - 0.0042 17.0 0.0 77 3.3 0.0 6.7 10 0 0 10 10 10 0 Protein of unknown function (DUF2530) NPL4 PF05021.10 ESA04706.1 - 1e-118 396.0 0.0 1.3e-118 395.6 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 ESA04706.1 - 1.5e-67 225.8 0.1 2.6e-67 225.0 0.1 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 ESA04706.1 - 2e-09 37.5 0.0 5.3e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 zf-RanBP PF00641.13 ESA04706.1 - 0.0038 16.2 1.8 0.0038 16.2 1.2 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Statherin PF03875.8 ESA04706.1 - 4.9 7.1 7.6 0.64 9.9 0.9 2.4 2 0 0 2 2 2 0 Statherin UNC-50 PF05216.8 ESA04707.1 - 3.1e-89 298.1 26.3 3.5e-89 297.9 18.2 1.0 1 0 0 1 1 1 1 UNC-50 family zf-C2H2_jaz PF12171.3 ESA04708.1 - 3.6e-07 30.1 1.7 5.7e-07 29.4 1.2 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA04708.1 - 6.3e-07 29.3 1.8 1e-06 28.7 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.7 ESA04708.1 - 7e-05 22.2 1.0 0.00012 21.5 0.7 1.4 1 0 0 1 1 1 1 U1 zinc finger Viral_P18 PF04521.8 ESA04708.1 - 0.037 13.4 7.1 0.069 12.5 4.6 1.8 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF1777 PF08648.7 ESA04708.1 - 0.087 12.5 33.6 12 5.6 23.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1777) Med14 PF08638.6 ESA04709.1 - 7e-25 87.4 0.0 1.4e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 Med8 PF10232.4 ESA04711.1 - 6.4e-11 42.1 7.1 8.8e-11 41.7 4.9 1.3 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 DUF4200 PF13863.1 ESA04711.1 - 0.022 14.6 0.7 0.022 14.6 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.7 ESA04711.1 - 2.3 8.0 4.7 6.7 6.5 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Yae1_N PF09811.4 ESA04712.1 - 8.9e-07 28.3 2.2 1.2e-06 27.9 1.5 1.2 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Cnl2_NKP2 PF09447.5 ESA04712.1 - 0.069 12.8 0.1 0.099 12.3 0.1 1.3 1 0 0 1 1 1 0 Cnl2/NKP2 family protein ASF1_hist_chap PF04729.8 ESA04713.1 - 1.7e-69 232.3 1.3 2.1e-69 232.0 0.9 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0172 PF03665.8 ESA04713.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) DHO_dh PF01180.16 ESA04714.1 - 1e-75 254.4 0.0 2.5e-48 164.5 0.0 2.1 1 1 1 2 2 2 2 Dihydroorotate dehydrogenase E2F_TDP PF02319.15 ESA04715.1 - 9.6e-25 85.9 0.1 2.1e-24 84.8 0.1 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.14 ESA04715.1 - 0.012 15.3 0.1 0.028 14.1 0.0 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF4200 PF13863.1 ESA04715.1 - 0.024 14.5 2.9 0.046 13.6 2.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) B-block_TFIIIC PF04182.7 ESA04715.1 - 0.035 13.9 0.0 0.091 12.6 0.0 1.7 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC IncA PF04156.9 ESA04715.1 - 0.12 11.9 3.0 0.15 11.6 2.1 1.2 1 0 0 1 1 1 0 IncA protein ODV-E18 PF10717.4 ESA04715.1 - 2.3 7.7 4.5 3.9 6.9 3.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Cnd1_N PF12922.2 ESA04716.1 - 0.01 15.4 1.6 0.014 15.0 1.1 1.2 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term Peptidase_M49 PF03571.10 ESA04717.1 - 1.8e-08 32.9 2.0 1.3e-07 30.0 0.8 2.0 1 1 1 2 2 2 2 Peptidase family M49 HSP70 PF00012.15 ESA04718.1 - 5.3e-274 909.7 8.5 6e-274 909.5 5.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA04718.1 - 3.3e-16 58.8 0.3 4.3e-15 55.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA04718.1 - 0.0013 17.9 0.1 0.021 13.9 0.0 2.5 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.15 ESA04718.1 - 0.0036 16.6 0.0 1.5 8.0 0.0 2.5 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.11 ESA04718.1 - 0.007 15.9 0.0 0.016 14.8 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 ESA04718.1 - 0.037 12.8 0.4 0.46 9.2 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Spc97_Spc98 PF04130.8 ESA04719.1 - 1.3e-103 347.1 4.8 1.5e-103 346.9 3.3 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family UbiA PF01040.13 ESA04720.1 - 1.2e-34 119.7 16.1 1.5e-34 119.4 11.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4265 PF14085.1 ESA04723.1 - 0.043 13.5 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) Vpu PF00558.14 ESA04724.1 - 0.052 13.1 0.6 0.1 12.1 0.4 1.5 1 0 0 1 1 1 0 Vpu protein DUF2535 PF10751.4 ESA04728.1 - 0.0029 17.7 4.0 0.69 10.0 0.0 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2535) DUF4134 PF13572.1 ESA04728.1 - 0.0067 16.5 0.1 1.6 8.9 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4134) HyaE PF07449.6 ESA04728.1 - 0.037 13.9 0.0 12 5.8 0.0 2.9 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE DUF2789 PF10982.3 ESA04728.1 - 0.048 13.6 6.7 7.3 6.6 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2789) Toxin_15 PF07906.8 ESA04729.1 - 0.00053 19.5 2.1 0.0006 19.3 1.5 1.0 1 0 0 1 1 1 1 ShET2 enterotoxin, N-terminal region Tape_meas_lam_C PF09718.5 ESA04730.1 - 0.054 13.4 0.2 10 6.1 0.0 2.7 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) PsbY PF06298.6 ESA04730.1 - 0.11 12.0 0.0 19 4.8 0.0 2.5 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) DUF1912 PF08930.5 ESA04730.1 - 0.2 11.7 3.5 4.5 7.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) Kelch_4 PF13418.1 ESA04731.1 - 7.5e-11 41.6 8.4 0.001 18.8 0.1 5.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA04731.1 - 1.1e-08 34.4 0.6 0.031 14.0 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 ESA04731.1 - 4.4e-08 32.9 8.5 0.26 11.5 0.1 5.4 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESA04731.1 - 5.8e-08 32.1 6.8 0.21 11.1 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.1 ESA04731.1 - 2.8e-06 27.1 1.2 3.8 7.5 0.1 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA04731.1 - 5e-05 23.3 3.8 0.81 9.9 0.0 5.5 6 0 0 6 6 6 2 Galactose oxidase, central domain DEAD PF00270.24 ESA04732.1 - 2e-20 72.9 0.0 1.2e-19 70.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA04732.1 - 4.3e-15 55.3 0.4 5.3e-14 51.8 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA04732.1 - 3.8e-07 30.1 0.9 8.5e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DivIC PF04977.10 ESA04732.1 - 0.0058 16.0 1.3 0.0058 16.0 0.9 2.6 3 0 0 3 3 3 1 Septum formation initiator HALZ PF02183.13 ESA04733.1 - 0.059 13.0 0.6 0.1 12.3 0.4 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper p450 PF00067.17 ESA04734.1 - 7.1e-67 225.9 0.0 1.2e-66 225.2 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 SNAPc_SNAP43 PF09808.4 ESA04734.1 - 0.024 14.2 0.2 0.039 13.6 0.1 1.3 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 DUF2408 PF10303.4 ESA04735.1 - 0.055 13.5 0.4 0.18 11.9 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Phage-A118_gp45 PF10653.4 ESA04736.1 - 0.0053 16.5 0.2 63 3.5 0.0 4.5 5 0 0 5 5 5 0 Protein gp45 of Bacteriophage A118 TRAP_alpha PF03896.11 ESA04736.1 - 0.013 14.4 4.7 2.5 7.0 0.0 4.0 5 0 0 5 5 5 0 Translocon-associated protein (TRAP), alpha subunit BCS1_N PF08740.6 ESA04736.1 - 0.019 14.5 0.1 8.7 5.9 0.0 3.1 3 0 0 3 3 3 0 BCS1 N terminal DUF3991 PF13154.1 ESA04736.1 - 1.7 8.8 10.6 1 9.5 0.0 4.5 6 0 0 6 6 6 0 Protein of unknown function (DUF3991) Glyco_hydro_11 PF00457.12 ESA04736.1 - 3.4 6.9 16.1 1.2 8.3 0.4 3.7 3 0 0 3 3 3 0 Glycosyl hydrolases family 11 Transformer PF06495.6 ESA04737.1 - 0.0019 18.0 17.4 0.0033 17.3 12.0 1.3 1 0 0 1 1 1 1 Fruit fly transformer protein SlyX PF04102.7 ESA04737.1 - 0.081 13.3 0.5 2.3 8.6 0.1 2.7 1 1 0 1 1 1 0 SlyX RRM_1 PF00076.17 ESA04737.1 - 0.1 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tmemb_cc2 PF10267.4 ESA04737.1 - 0.17 10.4 4.7 0.23 10.0 3.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF1664 PF07889.7 ESA04737.1 - 0.22 11.3 0.9 0.37 10.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Macoilin PF09726.4 ESA04737.1 - 1.6 6.8 13.4 2.4 6.3 9.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Phasin PF05597.6 ESA04738.1 - 0.031 14.0 0.8 0.045 13.5 0.4 1.4 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Glyco_hydro_42 PF02449.10 ESA04738.1 - 0.035 13.2 4.0 0.039 13.0 2.8 1.0 1 0 0 1 1 1 0 Beta-galactosidase DUF3235 PF11574.3 ESA04738.1 - 0.18 12.0 0.8 0.52 10.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3235) DUF1987 PF09345.5 ESA04738.1 - 0.53 10.1 4.4 0.27 11.0 1.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1987) YbjN PF10722.4 ESA04740.1 - 0.058 13.4 0.1 0.18 11.8 0.1 1.7 2 0 0 2 2 2 0 Putative bacterial sensory transduction regulator Phage_integrase PF00589.17 ESA04741.1 - 7.8e-08 32.1 0.0 1.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Cyclin PF08613.6 ESA04742.1 - 2e-16 60.7 0.1 2.4e-16 60.4 0.1 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESA04742.1 - 5.1e-16 58.3 0.0 6.1e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF815 PF05673.8 ESA04744.1 - 0.032 13.1 0.0 0.051 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Polysacc_synt_2 PF02719.10 ESA04744.1 - 0.086 11.7 0.1 0.17 10.7 0.1 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 ESA04744.1 - 0.092 12.7 0.0 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 NADH(P)-binding RmlD_sub_bind PF04321.12 ESA04744.1 - 0.13 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short PF00106.20 ESA04745.1 - 2.1e-14 53.7 0.0 3.5e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA04745.1 - 1.5e-10 41.0 0.0 2.1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESA04745.1 - 4.3e-10 39.7 0.0 5.9e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 ESA04745.1 - 7.1e-09 35.9 0.1 2e-08 34.4 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 ESA04745.1 - 1.9e-05 23.7 0.1 3.4e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 ESA04745.1 - 3e-05 23.5 0.1 6.2e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ELFV_dehydrog PF00208.16 ESA04745.1 - 9.6e-05 22.0 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_4 PF07993.7 ESA04745.1 - 0.00038 19.4 0.0 0.00057 18.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.8 ESA04745.1 - 0.00056 19.2 0.1 0.00079 18.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 ESA04745.1 - 0.0021 17.0 0.0 0.0031 16.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain F420_oxidored PF03807.12 ESA04745.1 - 0.0038 17.6 0.2 0.01 16.2 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.1 ESA04745.1 - 0.0068 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.15 ESA04745.1 - 0.0072 16.4 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.16 ESA04745.1 - 0.031 13.8 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3Beta_HSD PF01073.14 ESA04745.1 - 0.036 12.7 0.0 0.049 12.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 2-Hacid_dh_C PF02826.14 ESA04745.1 - 0.086 11.9 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Yqai PF09466.5 ESA04747.1 - 0.099 12.6 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Hypothetical protein Yqai Alba PF01918.16 ESA04748.1 - 0.064 12.8 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Alba Beta_protein PF14350.1 ESA04749.1 - 2e-32 112.7 0.0 7.4e-32 110.8 0.0 1.7 2 0 0 2 2 2 1 Beta protein DUF955 PF06114.8 ESA04749.1 - 1.1e-07 31.6 0.0 2e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF955) HTH_18 PF12833.2 ESA04750.1 - 1.7e-14 53.6 0.2 2e-14 53.4 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.18 ESA04750.1 - 8.2e-08 31.8 0.0 0.0019 18.0 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family SurA_N PF09312.6 ESA04750.1 - 0.066 13.0 0.1 0.08 12.8 0.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain HTH_36 PF13730.1 ESA04752.1 - 0.14 12.3 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Propeptide_C25 PF08126.6 ESA04754.1 - 0.028 13.4 0.0 0.038 12.9 0.0 1.3 1 0 0 1 1 1 0 Propeptide_C25 F-box-like PF12937.2 ESA04755.1 - 0.00081 19.0 2.2 0.0025 17.5 1.1 2.2 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.2 ESA04755.1 - 0.21 11.2 9.3 1.3 8.7 0.2 3.8 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA04755.1 - 1.6 8.5 9.2 12 5.6 0.8 4.3 3 3 2 5 5 5 0 Leucine rich repeat SIR2_2 PF13289.1 ESA04756.1 - 1.6e-21 76.6 0.0 3.9e-21 75.4 0.0 1.7 2 0 0 2 2 2 1 SIR2-like domain F-box-like_2 PF13013.1 ESA04757.1 - 0.006 16.2 0.3 0.0085 15.7 0.2 1.3 1 0 0 1 1 1 1 F-box-like domain ACCA PF03255.9 ESA04758.1 - 0.015 14.8 1.6 0.03 13.8 1.1 1.4 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit HiaBD2 PF15403.1 ESA04758.1 - 0.018 15.1 0.0 0.053 13.6 0.0 1.8 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) RNA_pol_Rpb1_2 PF00623.15 ESA04758.1 - 0.3 11.0 2.1 0.59 10.0 1.5 1.7 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 2 AAA_22 PF13401.1 ESA04760.1 - 2.2e-05 24.6 0.0 4.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 ESA04760.1 - 0.016 14.2 0.0 0.2 10.5 0.0 1.9 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) zf-C4_Topoisom PF01396.14 ESA04761.1 - 1.9e-08 33.6 0.9 3.3e-08 32.8 0.6 1.3 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger Mrr_cat PF04471.7 ESA04761.1 - 8e-05 22.4 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease zf-GRF PF06839.7 ESA04761.1 - 0.0052 16.6 0.8 0.0084 16.0 0.5 1.3 1 0 0 1 1 1 1 GRF zinc finger zf-TFIIB PF13453.1 ESA04761.1 - 0.0061 15.7 0.4 0.015 14.4 0.2 1.8 2 0 0 2 2 2 1 Transcription factor zinc-finger YdjO PF14169.1 ESA04761.1 - 0.11 11.9 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 Cold-inducible protein YdjO Phage_integrase PF00589.17 ESA04763.1 - 7.1e-09 35.5 0.0 1.7e-08 34.3 0.0 1.6 2 0 0 2 2 2 1 Phage integrase family Rad17 PF03215.10 ESA04763.1 - 0.03 13.0 0.0 0.046 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF2586 PF10758.4 ESA04763.1 - 0.084 11.9 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) F-box-like PF12937.2 ESA04764.1 - 0.00019 21.0 1.2 0.0005 19.7 0.8 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA04764.1 - 0.001 18.6 0.5 0.0059 16.2 0.3 2.4 1 0 0 1 1 1 1 F-box domain Dimer_Tnp_hAT PF05699.9 ESA04765.1 - 0.056 13.0 0.7 0.075 12.6 0.5 1.2 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region MVIN PF03023.9 ESA04766.1 - 0.012 14.0 0.5 0.015 13.7 0.4 1.1 1 0 0 1 1 1 0 MviN-like protein ATPgrasp_TupA PF14305.1 ESA04767.1 - 0.037 13.3 0.1 0.037 13.3 0.1 1.0 1 0 0 1 1 1 0 TupA-like ATPgrasp FA_desaturase PF00487.19 ESA04768.1 - 1.3e-30 106.7 5.2 1.6e-30 106.4 3.6 1.1 1 0 0 1 1 1 1 Fatty acid desaturase RHD3 PF05879.7 ESA04769.1 - 0.00085 17.3 2.5 0.00095 17.2 1.8 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Apolipoprotein PF01442.13 ESA04769.1 - 0.0029 17.1 3.7 0.0073 15.8 2.6 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain OmpH PF03938.9 ESA04769.1 - 0.0084 16.0 4.7 0.012 15.5 3.3 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) Tup_N PF08581.5 ESA04769.1 - 0.01 16.0 2.6 0.01 16.0 1.8 3.0 1 1 0 2 2 2 0 Tup N-terminal DUF445 PF04286.7 ESA04769.1 - 0.012 15.1 1.8 0.014 14.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ApoLp-III PF07464.6 ESA04769.1 - 0.013 15.5 3.5 0.14 12.1 0.2 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) BMFP PF04380.8 ESA04769.1 - 0.025 14.7 2.2 0.97 9.6 0.1 2.3 1 1 1 2 2 2 0 Membrane fusogenic activity DUF4085 PF13315.1 ESA04769.1 - 0.028 13.7 3.2 0.041 13.2 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Mitofilin PF09731.4 ESA04769.1 - 0.043 12.4 8.3 0.069 11.8 5.7 1.3 1 1 0 1 1 1 0 Mitochondrial inner membrane protein Prominin PF05478.6 ESA04769.1 - 0.049 11.1 5.8 0.063 10.8 4.1 1.1 1 0 0 1 1 1 0 Prominin DUF883 PF05957.8 ESA04769.1 - 0.06 13.7 0.9 4.6 7.7 0.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Taeniidae_ag PF05596.6 ESA04769.1 - 0.07 12.9 2.1 4.2 7.2 0.1 2.7 1 1 2 3 3 3 0 Taeniidae antigen Baculo_PEP_C PF04513.7 ESA04769.1 - 0.078 12.7 7.8 0.64 9.8 5.4 2.0 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TIP120 PF08623.5 ESA04769.1 - 0.15 11.6 4.0 0.32 10.5 2.8 1.5 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) YtxH PF12732.2 ESA04769.1 - 0.23 11.8 2.6 9.4 6.6 1.8 2.2 1 1 0 1 1 1 0 YtxH-like protein DUF2862 PF11061.3 ESA04769.1 - 0.29 10.8 5.2 2.3 7.9 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2862) Band_7 PF01145.20 ESA04769.1 - 0.34 10.7 3.7 0.9 9.4 2.5 1.6 1 1 0 1 1 1 0 SPFH domain / Band 7 family RRF PF01765.14 ESA04769.1 - 0.39 10.1 8.1 0.81 9.1 5.6 1.5 1 1 0 1 1 1 0 Ribosome recycling factor AKNA PF12443.3 ESA04769.1 - 0.48 10.4 2.6 3 7.8 0.1 2.2 1 1 1 2 2 2 0 AT-hook-containing transcription factor CorA PF01544.13 ESA04769.1 - 0.52 9.2 6.4 0.67 8.9 0.1 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Polysacc_deac_1 PF01522.16 ESA04769.1 - 0.58 9.7 3.1 26 4.4 0.1 2.9 1 1 2 3 3 3 0 Polysaccharide deacetylase DUF1317 PF07026.6 ESA04769.1 - 0.67 9.8 7.1 19 5.2 0.3 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1317) PRESAN PF09687.5 ESA04769.1 - 0.69 9.9 11.0 83 3.2 7.6 2.2 1 1 0 1 1 1 0 Plasmodium RESA N-terminal DUF1664 PF07889.7 ESA04769.1 - 1.3 8.8 6.2 3.6 7.3 3.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Phe_tRNA-synt_N PF02912.13 ESA04769.1 - 1.6 8.5 10.2 2.9 7.6 2.4 2.8 1 1 1 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain COG2 PF06148.6 ESA04769.1 - 2.1 8.2 8.1 13 5.6 0.5 2.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlxA PF14282.1 ESA04769.1 - 2.5 8.0 6.5 5.6 6.9 4.5 1.6 1 1 0 1 1 1 0 FlxA-like protein K-box PF01486.12 ESA04769.1 - 3 7.7 13.9 8.4 6.2 9.6 1.7 1 1 0 1 1 1 0 K-box region MazG PF03819.12 ESA04769.1 - 3.1 7.8 5.7 22 5.1 2.0 2.8 1 1 1 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain ATP-synt_B PF00430.13 ESA04769.1 - 3.2 7.5 9.4 14 5.4 0.4 2.1 1 1 0 2 2 2 0 ATP synthase B/B' CF(0) DUF749 PF05370.6 ESA04769.1 - 3.6 7.5 12.3 14 5.7 0.5 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF749) Syntaxin_2 PF14523.1 ESA04769.1 - 6.2 6.9 10.2 6.6e+02 0.4 7.0 2.7 1 1 0 1 1 1 0 Syntaxin-like protein AAA PF00004.24 ESA04770.1 - 2.1e-05 24.7 0.8 0.11 12.7 0.0 5.0 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA04770.1 - 2.7e-05 23.9 0.0 0.0031 17.2 0.0 3.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESA04770.1 - 0.0016 18.5 0.0 0.16 12.1 0.0 3.6 2 1 1 3 3 3 1 AAA domain Miro PF08477.8 ESA04770.1 - 0.0021 18.5 0.2 0.033 14.7 0.0 2.9 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 ESA04770.1 - 0.36 10.7 0.0 4.8 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.1 ESA04770.1 - 0.89 9.3 0.0 27 4.6 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain DUF4284 PF14112.1 ESA04772.1 - 7.4e-26 91.0 0.0 1.7e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4284) Imm-NTF2 PF15655.1 ESA04772.1 - 8.8e-10 39.1 0.0 1.3e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 NTF2 fold immunity protein Nudix_N PF12535.3 ESA04772.1 - 0.098 12.1 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal Neuregulin PF02158.10 ESA04774.1 - 0.081 11.6 0.2 0.084 11.6 0.2 1.1 1 0 0 1 1 1 0 Neuregulin family SHOCT PF09851.4 ESA04775.1 - 4.9e-06 25.8 0.2 9.8e-06 24.8 0.2 1.6 1 0 0 1 1 1 1 Short C-terminal domain DUF456 PF04306.8 ESA04775.1 - 0.031 14.3 1.7 0.12 12.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF456) EF-hand_8 PF13833.1 ESA04775.1 - 0.056 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Gly-zipper_Omp PF13488.1 ESA04775.1 - 3.7 7.2 14.3 0.15 11.6 4.8 2.2 2 0 0 2 2 2 0 Glycine zipper Pkinase_Tyr PF07714.12 ESA04777.1 - 4.1e-22 78.5 0.1 5.2e-22 78.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04777.1 - 9.2e-22 77.4 0.6 1.2e-21 77.0 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Methyltransf_11 PF08241.7 ESA04779.1 - 1e-16 61.2 0.0 4.9e-16 58.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA04779.1 - 8.1e-14 51.6 0.0 1.8e-13 50.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA04779.1 - 1.6e-12 47.2 0.0 7.2e-12 45.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA04779.1 - 2.5e-11 43.8 0.0 6.5e-11 42.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA04779.1 - 8.6e-11 42.1 0.0 1.6e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA04779.1 - 2.4e-09 36.6 0.0 5.4e-09 35.5 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA04779.1 - 1e-07 32.5 0.0 1.2e-06 29.1 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA04779.1 - 2.1e-06 26.9 0.0 3.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA04779.1 - 0.00015 21.7 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESA04779.1 - 0.00018 20.8 0.0 0.00018 20.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase FtsJ PF01728.14 ESA04779.1 - 0.00072 19.5 0.0 0.00083 19.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 ESA04779.1 - 0.0055 16.3 0.0 0.0076 15.9 0.0 1.3 1 1 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.7 ESA04779.1 - 0.012 15.0 0.0 0.024 13.9 0.0 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.9 ESA04779.1 - 0.022 14.1 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 ESA04779.1 - 0.036 13.1 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Sulfakinin PF08257.6 ESA04779.1 - 3.3 7.8 4.8 3 8.0 1.2 2.5 2 0 0 2 2 2 0 Sulfakinin family AHH PF14412.1 ESA04780.1 - 2e-23 82.4 0.3 2.3e-23 82.2 0.2 1.0 1 0 0 1 1 1 1 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF2951 PF11166.3 ESA04781.1 - 0.46 10.3 3.4 0.59 10.0 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) SET PF00856.23 ESA04782.1 - 7.9e-07 29.5 0.0 1.2e-06 28.9 0.0 1.3 1 1 0 1 1 1 1 SET domain Glyco_hydro_32N PF00251.15 ESA04782.1 - 0.038 13.3 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain TraT PF05818.7 ESA04783.1 - 5.9e-05 22.5 1.7 0.27 10.6 0.0 3.3 3 0 0 3 3 3 2 Enterobacterial TraT complement resistance protein DUF4134 PF13572.1 ESA04783.1 - 0.0084 16.2 1.6 12 6.0 0.0 4.4 5 0 0 5 5 5 1 Domain of unknown function (DUF4134) DUF2789 PF10982.3 ESA04783.1 - 0.038 13.9 6.4 79 3.3 0.0 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2789) DUF2190 PF09956.4 ESA04783.1 - 3.7 7.3 5.3 21 4.9 0.0 3.8 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2190) Glutaredoxin PF00462.19 ESA04784.1 - 1.6e-21 76.0 0.1 2.1e-21 75.6 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 ESA04784.1 - 0.00011 22.3 0.0 0.00015 21.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.9 ESA04784.1 - 0.0011 19.2 0.2 0.0015 18.7 0.1 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.1 ESA04784.1 - 0.0021 18.2 0.5 0.0056 16.8 0.4 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.1 ESA04784.1 - 0.0034 17.1 0.1 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.1 ESA04784.1 - 0.0049 16.3 0.0 0.0053 16.2 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein GST_N_2 PF13409.1 ESA04784.1 - 0.027 14.4 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DSBA PF01323.15 ESA04784.1 - 0.11 12.0 0.1 0.38 10.2 0.0 1.8 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF258 PF03193.11 ESA04785.1 - 0.00046 19.3 0.0 0.00046 19.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 ESA04785.1 - 0.00084 19.1 0.0 0.0009 19.0 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase ABC_tran PF00005.22 ESA04785.1 - 0.001 19.3 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_14 PF13173.1 ESA04785.1 - 0.0014 18.5 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA04785.1 - 0.0019 18.1 0.0 0.0019 18.1 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.2 ESA04785.1 - 0.0025 17.2 0.0 0.0028 17.1 0.0 1.1 1 0 0 1 1 1 1 AAA-like domain MMR_HSR1 PF01926.18 ESA04785.1 - 0.003 17.4 0.0 0.0037 17.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Guanylate_kin PF00625.16 ESA04785.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Guanylate kinase AAA_17 PF13207.1 ESA04785.1 - 0.014 16.2 0.2 0.017 15.9 0.1 1.3 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 ESA04785.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 ESA04785.1 - 0.017 15.4 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESA04785.1 - 0.017 14.6 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.1 ESA04785.1 - 0.04 13.8 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA04785.1 - 0.048 13.8 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Miro PF08477.8 ESA04785.1 - 0.054 13.9 0.0 0.063 13.7 0.0 1.2 1 0 0 1 1 1 0 Miro-like protein AAA_33 PF13671.1 ESA04785.1 - 0.057 13.3 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA04785.1 - 0.066 13.3 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 ESA04785.1 - 0.069 11.9 0.0 0.077 11.8 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain FtsK_SpoIIIE PF01580.13 ESA04785.1 - 0.087 12.2 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.8 ESA04785.1 - 0.09 11.6 0.0 0.09 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 ESA04785.1 - 0.094 11.8 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin Translin PF01997.11 ESA04788.1 - 1.9e-48 164.7 2.0 2.1e-48 164.5 1.4 1.0 1 0 0 1 1 1 1 Translin family BLOC1_2 PF10046.4 ESA04788.1 - 0.031 14.4 0.3 0.43 10.7 0.0 2.4 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2645 PF10840.3 ESA04788.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2645) GMP_synt_C PF00958.17 ESA04788.1 - 0.082 12.6 0.0 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 GMP synthase C terminal domain DUF4557 PF15101.1 ESA04789.1 - 1.8e-11 44.2 0.8 1.8e-11 44.2 0.6 2.3 2 2 0 2 2 2 1 Domain of unknown function (DUF4557) WD40 PF00400.27 ESA04790.1 - 6.9e-30 101.8 7.6 3e-07 30.0 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat SSrecog PF03531.9 ESA04791.1 - 2.6e-79 265.6 4.4 9.3e-78 260.5 3.1 2.3 1 1 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 ESA04791.1 - 1.6e-27 95.3 0.0 8.9e-25 86.5 0.0 2.7 2 0 0 2 2 2 2 Histone chaperone Rttp106-like RNA_pol_Rpb8 PF03870.10 ESA04792.1 - 1.1e-39 135.7 4.6 9.7e-38 129.4 3.2 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb8 WG_beta_rep PF14903.1 ESA04793.1 - 0.3 11.3 1.3 0.86 9.9 0.1 2.2 2 0 0 2 2 2 0 WG containing repeat DUF4624 PF15417.1 ESA04794.1 - 0.052 13.1 0.0 0.071 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) Phage-scaffold PF09306.5 ESA04795.1 - 0.044 12.9 0.3 0.052 12.6 0.2 1.1 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein Med16 PF11635.3 ESA04795.1 - 0.089 10.7 0.3 0.094 10.6 0.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 16 DUF3633 PF12315.3 ESA04795.1 - 0.13 11.5 0.8 0.15 11.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) Casc1 PF12366.3 ESA04795.1 - 0.26 10.7 3.5 0.29 10.5 2.5 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Kin17_mid PF10357.4 ESA04795.1 - 0.77 9.4 5.6 0.99 9.0 3.9 1.2 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein DUF3373 PF11853.3 ESA04795.1 - 2.3 6.6 5.3 2.5 6.5 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Ctf8 PF09696.5 ESA04795.1 - 3 7.6 6.6 13 5.5 4.6 1.9 1 1 0 1 1 1 0 Ctf8 SAPS PF04499.10 ESA04796.1 - 5e-90 302.4 5.7 5.9e-90 302.1 4.0 1.0 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein VirDNA-topo-I_N PF09266.5 ESA04797.1 - 0.12 12.2 0.4 0.16 11.9 0.3 1.2 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal Pkinase_Tyr PF07714.12 ESA04798.1 - 1.3e-34 119.4 0.1 3.6e-33 114.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04798.1 - 7.6e-31 107.2 0.2 1.3e-26 93.3 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ESA04798.1 - 0.0002 20.7 0.5 0.00034 20.0 0.3 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA04798.1 - 0.0034 16.4 0.0 0.0051 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA04798.1 - 0.0089 15.2 0.3 0.019 14.1 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA04798.1 - 0.031 13.5 0.3 0.087 12.1 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA04798.1 - 0.055 12.4 0.0 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Aldo_ket_red PF00248.16 ESA04802.1 - 1e-10 40.9 0.0 1.1e-10 40.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3068 PF11271.3 ESA04803.1 - 0.0095 15.0 1.8 0.013 14.6 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3068) Cu_bind_like PF02298.12 ESA04804.1 - 9.9e-05 22.0 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 Plastocyanin-like domain Plasmodium_Vir PF05795.6 ESA04804.1 - 0.0056 15.9 0.2 0.0071 15.5 0.1 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein EIIC-GAT PF03611.9 ESA04804.1 - 0.053 12.2 0.0 0.092 11.5 0.0 1.3 1 0 0 1 1 1 0 PTS system sugar-specific permease component Gly-zipper_Omp PF13488.1 ESA04804.1 - 0.057 13.0 0.3 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Glycine zipper DUF4064 PF13273.1 ESA04804.1 - 0.059 13.4 0.6 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF872 PF05915.7 ESA04804.1 - 0.099 12.5 0.0 0.62 9.9 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF3169 PF11368.3 ESA04804.1 - 0.16 11.1 0.2 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Myb_DNA-bind_6 PF13921.1 ESA04805.1 - 0.00038 20.5 0.6 0.00072 19.6 0.1 1.8 2 1 0 2 2 2 1 Myb-like DNA-binding domain Homeobox PF00046.24 ESA04806.1 - 5.5e-21 73.9 2.1 1e-20 73.0 1.5 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 ESA04806.1 - 0.0021 17.7 0.3 0.0041 16.7 0.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain GerE PF00196.14 ESA04806.1 - 0.018 14.3 0.4 0.036 13.3 0.3 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 ESA04806.1 - 0.12 12.0 0.1 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Cu-oxidase_2 PF07731.9 ESA04809.1 - 2.4e-19 69.1 0.9 1.6e-17 63.2 0.5 2.5 2 1 0 2 2 2 1 Multicopper oxidase CN_hydrolase PF00795.17 ESA04810.1 - 4.8e-08 32.5 0.0 6.3e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pkinase PF00069.20 ESA04812.1 - 6.3e-11 41.9 0.0 6.7e-11 41.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04812.1 - 3.5e-09 36.1 0.0 3.6e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Aldo_ket_red PF00248.16 ESA04813.1 - 6.7e-44 149.8 0.1 8.1e-44 149.5 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3160 PF11369.3 ESA04814.1 - 0.24 9.7 1.9 0.3 9.3 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) DUF3764 PF12594.3 ESA04815.1 - 0.018 14.7 0.4 0.031 14.0 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3764) RNA_pol_Rpb6 PF01192.17 ESA04815.1 - 0.024 14.3 0.3 4.7 7.0 0.0 2.2 2 1 0 2 2 2 0 RNA polymerase Rpb6 PQ-loop PF04193.9 ESA04816.1 - 8.6e-21 73.2 9.1 3.1e-11 42.6 0.7 3.3 3 1 1 4 4 4 2 PQ loop repeat DUF3159 PF11361.3 ESA04816.1 - 1.3 8.4 3.8 1 8.7 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3159) DUF4615 PF15393.1 ESA04817.1 - 0.39 10.9 5.1 0.087 13.0 0.6 2.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4615) SAS4 PF15460.1 ESA04817.1 - 5.8 6.8 7.4 6 6.7 0.2 2.8 3 0 0 3 3 3 0 Something about silencing, SAS, complex subunit 4 PIF1 PF05970.9 ESA04818.1 - 1.6e-05 24.0 0.0 1.6e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase Spore_YhaL PF14147.1 ESA04819.1 - 0.008 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Sporulation protein YhaL Methyltransf_27 PF13708.1 ESA04820.1 - 0.021 14.3 0.2 0.023 14.2 0.1 1.1 1 0 0 1 1 1 0 Methyltransferase domain RNA_pol_I_A49 PF06870.7 ESA04820.1 - 0.13 10.8 0.6 0.13 10.8 0.4 1.0 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor CN_hydrolase PF00795.17 ESA04821.1 - 1.1e-08 34.6 0.0 1.4e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Methyltransf_23 PF13489.1 ESA04822.1 - 1.2e-06 28.3 0.0 1.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA04822.1 - 4.8e-06 26.9 0.0 7.9e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA04822.1 - 0.00027 20.0 0.0 0.00073 18.6 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESA04822.1 - 0.0061 17.1 0.0 0.058 13.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain DUF2009 PF09418.5 ESA04823.1 - 1.6e-116 389.8 0.5 1.7e-116 389.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) GIDA PF01134.17 ESA04824.1 - 5.8e-157 522.5 0.0 7.4e-157 522.2 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 ESA04824.1 - 2.2e-22 78.8 0.0 2.5e-21 75.5 0.0 2.7 2 0 0 2 2 2 1 GidA associated domain 3 FAD_oxidored PF12831.2 ESA04824.1 - 1.1e-05 24.6 0.0 1.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESA04824.1 - 3.3e-05 23.8 0.2 0.00013 21.9 0.2 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESA04824.1 - 0.00033 19.6 1.8 0.00051 19.0 0.4 1.9 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 ESA04824.1 - 0.00092 18.2 0.6 0.44 9.3 0.4 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.9 ESA04824.1 - 0.0077 14.7 1.7 0.062 11.7 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein AlaDh_PNT_C PF01262.16 ESA04824.1 - 0.032 13.7 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 ESA04824.1 - 0.1 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Clr2 PF10383.4 ESA04825.1 - 1.8e-08 34.4 0.0 1.2e-07 31.7 0.0 2.2 1 1 0 1 1 1 1 Transcription-silencing protein Clr2 Trigger_N PF05697.8 ESA04825.1 - 0.019 14.7 1.7 0.37 10.5 0.3 2.7 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) SYF2 PF08231.7 ESA04826.1 - 1.9e-38 132.0 19.9 1.9e-38 132.0 13.8 2.5 1 1 0 2 2 2 1 SYF2 splicing factor BTB PF00651.26 ESA04827.1 - 2.2e-12 46.9 0.5 2.5e-11 43.5 0.4 2.3 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04827.1 - 0.05 13.4 0.0 0.27 11.0 0.0 2.1 1 1 1 2 2 2 0 BTB And C-terminal Kelch BTB PF00651.26 ESA04828.1 - 3e-16 59.4 0.0 5.6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA04828.1 - 3.3e-07 30.0 1.0 0.00087 19.1 0.1 2.9 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF2063 PF09836.4 ESA04828.1 - 0.0039 17.1 0.1 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2063) TPR_11 PF13414.1 ESA04829.1 - 0.14 11.8 3.1 0.19 11.4 0.1 2.7 3 1 0 3 3 3 0 TPR repeat MspA PF09203.6 ESA04833.1 - 0.12 11.7 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 MspA Staphostatin_A PF09022.5 ESA04834.1 - 0.016 14.9 0.1 0.016 14.9 0.0 2.3 2 1 0 2 2 2 0 Staphostatin A MFS_1 PF07690.11 ESA04838.1 - 7.2e-41 140.0 36.7 1.5e-29 102.7 7.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA04838.1 - 3.8e-21 75.1 32.1 1.3e-19 70.0 22.0 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 ESA04838.1 - 0.28 9.2 10.8 0.59 8.1 3.2 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector SWIM PF04434.12 ESA04839.1 - 0.036 13.5 3.4 0.052 13.0 0.5 2.3 2 0 0 2 2 2 0 SWIM zinc finger PROL5-SMR PF15621.1 ESA04840.1 - 1.2 9.6 4.3 2.3 8.7 3.0 1.5 1 1 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family Rib_recp_KP_reg PF05104.7 ESA04840.1 - 9.4 6.7 8.2 11 6.5 5.7 1.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Nup54 PF13874.1 ESA04843.1 - 0.00057 19.5 2.8 0.00057 19.5 2.0 3.3 3 1 1 4 4 4 1 Nucleoporin complex subunit 54 MADF_DNA_bdg PF10545.4 ESA04843.1 - 0.00073 19.6 4.6 0.0068 16.5 0.2 3.0 1 1 1 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like TPR_MLP1_2 PF07926.7 ESA04843.1 - 0.056 13.1 17.3 0.12 12.1 8.7 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Apolipoprotein PF01442.13 ESA04843.1 - 0.064 12.7 5.0 0.4 10.1 0.6 2.4 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain Uds1 PF15456.1 ESA04843.1 - 0.17 11.9 6.1 0.66 9.9 2.2 2.8 1 1 0 2 2 2 0 Up-regulated During Septation Prefoldin_2 PF01920.15 ESA04843.1 - 0.52 10.1 19.2 3.9 7.2 0.2 4.2 3 1 1 4 4 4 0 Prefoldin subunit OmpH PF03938.9 ESA04843.1 - 0.54 10.1 13.1 1.9 8.4 7.0 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) PAP_fibrillin PF04755.7 ESA04843.1 - 0.65 9.6 6.7 0.86 9.2 4.6 1.2 1 0 0 1 1 1 0 PAP_fibrillin CAT PF00302.13 ESA04843.1 - 0.67 9.5 11.8 0.24 10.9 0.9 2.1 1 1 1 2 2 2 0 Chloramphenicol acetyltransferase DUF342 PF03961.8 ESA04843.1 - 0.68 8.2 20.1 0.065 11.6 8.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF342) HALZ PF02183.13 ESA04843.1 - 1.6 8.5 10.8 16 5.2 0.9 4.0 3 1 1 4 4 4 0 Homeobox associated leucine zipper TBPIP PF07106.8 ESA04843.1 - 1.6 8.2 22.8 0.11 12.0 8.1 2.9 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SlyX PF04102.7 ESA04843.1 - 3.3 8.1 12.7 7.3 7.0 2.2 3.5 3 1 0 3 3 3 0 SlyX FlaC_arch PF05377.6 ESA04843.1 - 4.4 7.2 18.7 0.44 10.4 1.5 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) FadA PF09403.5 ESA04843.1 - 5.4 7.0 14.9 0.45 10.5 4.9 2.6 2 1 1 3 3 3 0 Adhesion protein FadA Sugarporin_N PF11471.3 ESA04843.1 - 5.8 6.6 7.5 8.9 6.0 1.3 2.7 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Pkinase_Tyr PF07714.12 ESA04844.1 - 1.6e-43 148.6 0.0 2.2e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04844.1 - 6.5e-38 130.3 0.0 9e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA04844.1 - 0.0025 17.1 0.1 0.0044 16.3 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA04844.1 - 0.0049 16.6 0.0 0.0094 15.7 0.0 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA04844.1 - 0.011 14.7 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA04844.1 - 0.041 13.0 0.2 0.062 12.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Docking PF08990.6 ESA04844.1 - 0.2 10.8 0.2 0.2 10.8 0.2 2.0 2 0 0 2 2 2 0 Erythronolide synthase docking DUF3439 PF11921.3 ESA04845.1 - 0.12 12.1 3.0 0.17 11.6 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SEA PF01390.15 ESA04847.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 SEA domain Pkinase PF00069.20 ESA04848.1 - 1.1e-30 106.6 0.1 1.3e-30 106.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04848.1 - 6e-30 104.1 0.0 7e-30 103.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA04848.1 - 0.0027 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA04848.1 - 0.02 13.9 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA04848.1 - 0.025 13.9 0.0 0.05 12.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESA04848.1 - 0.042 12.8 0.0 0.05 12.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.20 ESA04849.1 - 3.5e-28 98.4 0.2 1.4e-26 93.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA04849.1 - 6.2e-28 97.5 0.0 2.3e-26 92.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA04849.1 - 0.092 12.4 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA04850.1 - 3.8e-50 170.3 0.1 1.4e-49 168.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04850.1 - 3.6e-48 163.9 0.2 8.6e-48 162.7 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04850.1 - 0.0047 16.6 0.1 0.0086 15.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family WASH_WAHD PF11945.3 ESA04850.1 - 0.81 8.9 11.1 0.17 11.1 1.0 2.9 3 1 1 4 4 4 0 WAHD domain of WASH complex Imm22 PF15592.1 ESA04850.1 - 0.99 9.7 16.2 1.3 9.3 0.3 4.2 2 2 3 5 5 5 0 Immunity protein 22 FlgN PF05130.7 ESA04851.1 - 0.094 12.9 0.0 0.097 12.9 0.0 1.1 1 0 0 1 1 1 0 FlgN protein DUF629 PF04780.7 ESA04854.1 - 0.013 14.0 0.7 0.013 14.0 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) DUF4325 PF14213.1 ESA04854.1 - 0.082 12.5 0.2 0.18 11.4 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4325) LRR_6 PF13516.1 ESA04858.1 - 3.6 7.9 10.5 0.83 9.9 0.4 4.5 3 1 1 4 4 4 0 Leucine Rich repeat Arrestin_N PF00339.24 ESA04859.1 - 2.5e-06 27.3 0.6 9.6e-06 25.4 0.4 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Folate_rec PF03024.9 ESA04861.1 - 0.0031 17.1 0.5 0.0033 17.0 0.3 1.1 1 0 0 1 1 1 1 Folate receptor family TraT PF05818.7 ESA04861.1 - 0.052 12.9 0.1 0.055 12.8 0.1 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF3568 PF12092.3 ESA04861.1 - 0.064 12.9 0.4 0.099 12.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3568) Abi PF02517.11 ESA04862.1 - 4.3e-15 55.6 7.4 4.3e-15 55.6 5.2 2.4 2 1 0 2 2 2 1 CAAX protease self-immunity HMG_box PF00505.14 ESA04865.1 - 6.3e-06 26.3 0.9 1.4e-05 25.3 0.3 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA04865.1 - 0.00036 20.8 1.0 0.0011 19.3 0.7 1.8 1 1 0 1 1 1 1 HMG-box domain Tet_JBP PF12851.2 ESA04865.1 - 0.046 13.0 0.7 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Oxygenase domain of the 2OGFeDO superfamily Epimerase PF01370.16 ESA04866.1 - 3.4e-52 177.2 0.0 4.3e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA04866.1 - 2.2e-18 65.9 0.0 9.8e-16 57.2 0.0 2.0 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 ESA04866.1 - 4.7e-16 58.5 0.0 7.2e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase_Csub PF13950.1 ESA04866.1 - 1.8e-15 56.5 0.1 1.4e-14 53.7 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose 4-epimerase C-term subunit Polysacc_synt_2 PF02719.10 ESA04866.1 - 6.4e-15 54.8 0.0 5.5e-14 51.7 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 ESA04866.1 - 1.7e-07 30.7 0.0 5.1e-05 22.6 0.0 2.3 2 1 0 2 2 2 2 NmrA-like family NAD_binding_4 PF07993.7 ESA04866.1 - 5.1e-07 28.8 0.0 1.1e-05 24.5 0.0 2.2 1 1 0 2 2 2 1 Male sterility protein adh_short PF00106.20 ESA04866.1 - 2e-06 27.8 0.0 6.4e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 ESA04866.1 - 3.2e-06 27.2 0.0 8.5e-06 25.8 0.0 1.8 1 1 0 1 1 1 1 NADH(P)-binding KR PF08659.5 ESA04866.1 - 0.00042 20.0 0.0 0.0084 15.7 0.0 2.3 1 1 0 1 1 1 1 KR domain DapB_N PF01113.15 ESA04866.1 - 0.034 14.0 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF1800 PF08811.6 ESA04866.1 - 0.2 10.5 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) Alpha-amylase PF00128.19 ESA04867.1 - 2e-30 106.2 0.1 2.7e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.6 ESA04867.1 - 1.7e-11 44.0 0.0 4.5e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) DUF3267 PF11667.3 ESA04868.1 - 0.0017 18.5 2.7 0.0017 18.5 1.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3267) DUF2789 PF10982.3 ESA04869.1 - 0.0063 16.5 4.2 30 4.7 0.0 4.8 5 0 0 5 5 5 1 Protein of unknown function (DUF2789) Salp15 PF12115.3 ESA04869.1 - 0.026 14.7 20.4 0.29 11.3 1.7 3.9 4 0 0 4 4 4 0 Salivary protein of 15kDa inhibits CD4+ T cell activation DUF2190 PF09956.4 ESA04869.1 - 0.07 12.9 3.0 13 5.5 0.0 4.1 5 0 0 5 5 5 0 Uncharacterized conserved protein (DUF2190) TraT PF05818.7 ESA04869.1 - 0.13 11.6 5.3 68 2.7 0.0 4.3 5 0 0 5 5 5 0 Enterobacterial TraT complement resistance protein DUF2971 PF11185.3 ESA04870.1 - 1.8e-13 50.9 0.4 4.7e-13 49.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2971) Spt20 PF12090.3 ESA04873.1 - 1.3e-09 37.6 0.8 5.8e-07 29.0 0.0 2.5 1 1 1 2 2 2 2 Spt20 family AIP3 PF03915.8 ESA04874.1 - 0.12 11.3 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Pkinase_Tyr PF07714.12 ESA04875.1 - 1.3e-41 142.4 0.0 1.6e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04875.1 - 2e-40 138.6 0.2 2.5e-40 138.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04875.1 - 0.055 13.2 0.3 0.085 12.5 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FF PF01846.14 ESA04877.1 - 1.6e-21 76.0 1.0 1.3e-11 44.2 0.0 3.3 3 0 0 3 3 3 3 FF domain NYD-SP28 PF14772.1 ESA04877.1 - 0.24 11.5 0.0 0.24 11.5 0.0 3.1 3 1 0 3 3 3 0 Sperm tail DUF349 PF03993.7 ESA04877.1 - 0.39 10.8 7.2 10 6.3 2.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) PBP_dimer PF03717.10 ESA04877.1 - 2.9 7.9 7.6 11 6.0 3.6 2.2 1 1 1 2 2 2 0 Penicillin-binding Protein dimerisation domain tRNA-synt_1 PF00133.17 ESA04878.1 - 2.8e-53 180.8 0.9 6.4e-53 179.6 0.6 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESA04878.1 - 0.00055 18.7 0.1 0.0018 17.0 0.0 1.9 2 1 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESA04878.1 - 0.0072 15.4 0.0 0.0093 15.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain CaMKII_AD PF08332.5 ESA04879.1 - 0.052 13.4 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association DUF1892 PF08987.5 ESA04879.1 - 0.089 12.8 0.4 0.16 11.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1892) Caps_synth PF05704.7 ESA04879.1 - 0.099 11.7 2.4 0.15 11.1 1.7 1.3 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein RTP PF02334.11 ESA04879.1 - 0.38 10.7 2.9 0.88 9.5 1.6 1.9 1 1 1 2 2 2 0 Replication terminator protein Pkinase_Tyr PF07714.12 ESA04880.1 - 5.2e-16 58.4 0.0 1e-15 57.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04880.1 - 1.1e-14 54.2 0.0 2.3e-14 53.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Mnd1 PF03962.10 ESA04880.1 - 0.0064 16.1 3.4 0.0097 15.5 2.3 1.2 1 0 0 1 1 1 1 Mnd1 family DUF4446 PF14584.1 ESA04880.1 - 0.016 15.0 1.2 0.024 14.4 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Elongin_A PF06881.6 ESA04880.1 - 7.6 6.9 10.4 0.89 9.9 0.3 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF4252 PF14060.1 ESA04881.1 - 0.053 13.0 1.2 0.059 12.9 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) Tubulin_C PF03953.12 ESA04881.1 - 0.079 13.0 0.2 0.085 12.8 0.1 1.1 1 0 0 1 1 1 0 Tubulin C-terminal domain HTH_WhiA PF02650.9 ESA04883.1 - 0.078 13.3 0.3 0.078 13.3 0.2 2.5 3 0 0 3 3 3 0 WhiA C-terminal HTH domain DUF3910 PF13049.1 ESA04884.1 - 0.066 13.3 0.2 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3910) DUF3420 PF11900.3 ESA04887.1 - 0.12 12.4 0.2 0.16 12.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) FAM177 PF14774.1 ESA04889.1 - 1.6 8.6 4.9 1.8 8.4 2.1 2.0 1 1 1 2 2 2 0 FAM177 family WW PF00397.21 ESA04892.1 - 1.1e-19 69.9 6.6 4.9e-10 39.0 0.7 2.6 2 0 0 2 2 2 2 WW domain FF PF01846.14 ESA04892.1 - 3e-11 43.0 0.1 3e-11 43.0 0.1 2.7 3 0 0 3 3 3 1 FF domain YHS PF04945.8 ESA04892.1 - 0.04 13.7 0.1 12 5.8 0.0 2.4 2 0 0 2 2 2 0 YHS domain Integrase_AP2 PF14657.1 ESA04892.1 - 0.92 9.3 3.7 0.32 10.7 0.3 2.0 2 0 0 2 2 2 0 AP2-like DNA-binding integrase domain Mit_KHE1 PF10173.4 ESA04894.1 - 0.0018 18.1 9.4 0.0057 16.5 2.6 2.3 1 1 1 2 2 2 2 Mitochondrial K+-H+ exchange-related Catalase-rel PF06628.7 ESA04894.1 - 0.039 13.7 0.1 8.6 6.3 0.0 2.9 2 0 0 2 2 2 0 Catalase-related immune-responsive Dev_Cell_Death PF10539.4 ESA04894.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Development and cell death domain CdhC PF03598.10 ESA04894.1 - 0.13 10.7 1.0 0.21 10.0 0.7 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit bZIP_2 PF07716.10 ESA04894.1 - 0.43 10.4 13.0 0.068 12.9 4.0 2.8 3 0 0 3 3 3 0 Basic region leucine zipper CENP-Q PF13094.1 ESA04894.1 - 1.3 9.0 11.3 0.1 12.5 2.7 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit KxDL PF10241.4 ESA04894.1 - 3.9 7.4 7.9 1.5 8.7 0.8 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein RasGEF_N PF00618.15 ESA04894.1 - 4.7 7.3 6.2 0.64 10.1 0.2 2.5 2 1 0 2 2 2 0 RasGEF N-terminal motif Glutaredoxin PF00462.19 ESA04895.1 - 4.3e-14 52.2 0.0 6.6e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 ESA04895.1 - 5.3e-05 23.3 0.0 0.0002 21.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Put_Phosphatase PF06888.7 ESA04897.1 - 0.029 13.5 0.6 0.035 13.2 0.4 1.1 1 0 0 1 1 1 0 Putative Phosphatase Lipoprotein_18 PF06804.6 ESA04897.1 - 0.094 11.4 1.0 0.1 11.3 0.7 1.1 1 0 0 1 1 1 0 NlpB/DapX lipoprotein DUF3916 PF13079.1 ESA04897.1 - 0.76 9.4 4.4 3.4 7.3 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3916) HMG_box PF00505.14 ESA04898.1 - 6.7e-14 51.9 2.5 8.7e-14 51.5 1.7 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA04898.1 - 0.0094 16.2 1.1 0.0094 16.2 0.8 1.3 1 1 0 1 1 1 1 HMG-box domain MRP_L53 PF10780.4 ESA04898.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 BTB PF00651.26 ESA04900.1 - 1.2e-14 54.2 0.2 2e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA04900.1 - 3.8e-14 52.8 0.5 2.1e-13 50.4 0.1 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA04900.1 - 4.1e-06 26.5 2.4 6.6e-05 22.7 0.3 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA04900.1 - 0.0024 18.0 0.2 0.36 11.0 0.0 2.7 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA04901.1 - 6.1e-13 48.9 0.2 1.1e-12 48.1 0.1 1.4 1 1 0 1 1 1 1 TLD Arch_ATPase PF01637.13 ESA04902.1 - 2.5e-15 56.8 2.2 3.4e-15 56.3 1.5 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESA04902.1 - 4.2e-07 30.1 0.0 9.7e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA04902.1 - 3.7e-06 27.1 0.1 4.1e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESA04902.1 - 0.00037 20.3 0.7 0.0053 16.6 0.5 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA04902.1 - 0.0004 20.4 0.0 0.0056 16.6 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 ESA04902.1 - 0.0056 15.5 0.0 0.016 14.0 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain ABC_tran PF00005.22 ESA04902.1 - 0.006 16.8 0.0 0.012 15.8 0.0 1.6 1 1 0 1 1 1 1 ABC transporter VirE PF05272.6 ESA04902.1 - 0.0078 15.7 0.1 0.041 13.3 0.0 2.0 2 0 0 2 2 2 1 Virulence-associated protein E AAA_17 PF13207.1 ESA04902.1 - 0.011 16.5 0.0 0.025 15.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESA04902.1 - 0.012 15.2 0.3 0.027 14.0 0.2 1.9 2 1 0 2 2 2 0 AAA domain RhoGEF PF00621.15 ESA04902.1 - 0.03 14.2 4.2 0.12 12.2 0.5 2.8 1 1 2 3 3 3 0 RhoGEF domain DUF815 PF05673.8 ESA04902.1 - 0.034 13.0 0.0 0.063 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF258 PF03193.11 ESA04902.1 - 0.088 11.9 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF1981 PF09324.5 ESA04902.1 - 0.097 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) Myb_DNA-binding PF00249.26 ESA04904.1 - 4.4e-05 23.4 1.2 0.28 11.2 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA04904.1 - 0.00043 20.3 0.5 0.00043 20.3 0.3 2.3 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA04904.1 - 0.032 14.8 5.7 0.04 14.5 1.6 2.2 1 1 2 3 3 3 0 Myb/SANT-like DNA-binding domain Fer2 PF00111.22 ESA04906.1 - 1.6e-12 46.9 0.4 2.6e-12 46.3 0.3 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain CTDII PF01556.13 ESA04906.1 - 0.093 12.6 0.1 5.8 6.8 0.0 2.4 2 0 0 2 2 2 0 DnaJ C terminal domain Zn_ribbon_2 PF12674.2 ESA04907.1 - 0.0041 17.4 0.3 0.0069 16.7 0.2 1.4 1 0 0 1 1 1 1 Putative zinc ribbon domain Ion_trans PF00520.26 ESA04908.1 - 7.6e-07 28.5 3.8 7.9e-07 28.5 2.7 1.2 1 0 0 1 1 1 1 Ion transport protein DUF4271 PF14093.1 ESA04908.1 - 0.016 14.9 2.3 0.024 14.3 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) DDE_Tnp_ISAZ013 PF07592.6 ESA04909.1 - 0.015 14.0 0.0 0.28 9.8 0.0 2.1 1 1 1 2 2 2 0 Rhodopirellula transposase DDE domain Fib_alpha PF08702.5 ESA04909.1 - 0.034 14.2 1.5 0.055 13.5 1.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family GcpE PF04551.9 ESA04909.1 - 0.13 10.9 0.2 0.18 10.5 0.2 1.1 1 0 0 1 1 1 0 GcpE protein SNARE_assoc PF09335.6 ESA04910.1 - 4e-21 75.4 8.0 4e-21 75.4 5.5 2.2 2 1 0 2 2 2 1 SNARE associated Golgi protein UDPGT PF00201.13 ESA04912.1 - 7e-05 21.5 0.0 0.00097 17.8 0.0 2.0 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.15 ESA04912.1 - 0.0082 15.9 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain DUF2572 PF10833.3 ESA04913.1 - 0.079 12.3 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Sel1 PF08238.7 ESA04914.1 - 4.9e-61 201.8 17.2 2.3e-10 40.7 0.3 6.9 7 0 0 7 7 7 6 Sel1 repeat TPR_17 PF13431.1 ESA04914.1 - 0.00051 20.0 21.4 9.6 6.6 0.0 6.5 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA04914.1 - 1.2 8.8 28.0 2.3 7.9 2.5 5.7 1 1 4 5 5 5 0 TPR repeat TPR_10 PF13374.1 ESA04914.1 - 1.7 8.6 19.2 25 4.9 0.1 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat Beta_helix PF13229.1 ESA04914.1 - 3.5 7.3 21.1 2.1 8.0 6.1 2.5 1 1 1 2 2 2 0 Right handed beta helix region Lectin_C PF00059.16 ESA04914.1 - 4 8.1 8.9 2.4 8.8 0.5 3.3 1 1 1 2 2 2 0 Lectin C-type domain TAN PF11640.3 ESA04915.1 - 0.19 11.4 2.0 4.4 7.0 0.0 2.0 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair zf-RanBP PF00641.13 ESA04916.1 - 0.1 11.7 1.7 0.26 10.4 1.2 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF4419 PF14388.1 ESA04917.1 - 1.9e-66 224.2 0.0 8.9e-65 218.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4419) CD99L2 PF12301.3 ESA04918.1 - 0.043 13.5 0.3 0.057 13.1 0.2 1.1 1 0 0 1 1 1 0 CD99 antigen like protein 2 MGC-24 PF05283.6 ESA04918.1 - 0.24 11.1 1.1 0.27 10.9 0.7 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) WD40 PF00400.27 ESA04919.1 - 0.00045 20.0 0.4 0.36 10.7 0.0 3.5 3 0 0 3 3 3 1 WD domain, G-beta repeat Serglycin PF04360.7 ESA04919.1 - 0.056 13.1 0.0 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 Serglycin PAP_PilO PF06864.7 ESA04919.1 - 0.084 11.2 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Zn_ribbon_recom PF13408.1 ESA04921.1 - 5.1e-11 42.6 0.9 1e-10 41.6 0.6 1.5 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain Recombinase PF07508.8 ESA04921.1 - 3.9e-05 23.8 0.3 0.00014 22.0 0.0 2.0 2 0 0 2 2 2 1 Recombinase HSF_DNA-bind PF00447.12 ESA04922.1 - 2.8e-19 69.2 0.1 3.3e-19 68.9 0.1 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding Translin PF01997.11 ESA04923.1 - 6.7e-53 179.2 0.7 7.9e-53 179.0 0.5 1.0 1 0 0 1 1 1 1 Translin family NMD3 PF04981.8 ESA04923.1 - 0.037 13.1 0.1 0.054 12.5 0.1 1.2 1 0 0 1 1 1 0 NMD3 family Iron_traffic PF04362.9 ESA04923.1 - 0.076 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking Bac_GDH PF05088.7 ESA04923.1 - 0.096 10.0 0.0 0.11 9.8 0.0 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DUF4265 PF14085.1 ESA04923.1 - 0.096 12.4 0.1 2.4 7.9 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4265) PKK PF12474.3 ESA04926.1 - 1.3 8.7 9.8 2.5 7.8 6.8 1.4 1 0 0 1 1 1 0 Polo kinase kinase HMG_box PF00505.14 ESA04927.1 - 5.6e-06 26.5 0.1 2.1e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA04927.1 - 0.00022 21.5 0.9 0.006 16.9 0.0 2.2 2 0 0 2 2 2 1 HMG-box domain C2 PF00168.25 ESA04928.1 - 4.1e-22 77.8 0.2 6.4e-22 77.2 0.2 1.3 1 0 0 1 1 1 1 C2 domain Mpp10 PF04006.7 ESA04929.1 - 7.1e-106 354.9 59.4 9.9e-106 354.4 41.2 1.2 1 0 0 1 1 1 1 Mpp10 protein WIYLD PF10440.4 ESA04929.1 - 0.0073 16.2 2.3 0.029 14.2 0.0 2.9 2 1 0 2 2 2 1 Ubiquitin-binding WIYLD domain NAAA-beta PF15508.1 ESA04929.1 - 0.033 14.5 0.3 0.2 12.0 0.0 2.4 2 1 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Acyl-CoA_dh_C PF12806.2 ESA04931.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.0 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like tRNA_m1G_MT PF01746.16 ESA04933.1 - 0.056 13.0 1.1 0.07 12.7 0.8 1.2 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase LCD1 PF09798.4 ESA04933.1 - 0.088 10.7 3.7 0.11 10.5 2.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein GRIN_C PF15235.1 ESA04933.1 - 5.5 7.0 6.9 0.92 9.5 0.7 1.9 1 1 1 2 2 2 0 G protein-regulated inducer of neurite outgrowth C-terminus Sigma70_r1_1 PF03979.9 ESA04935.1 - 0.028 14.3 0.7 0.061 13.2 0.3 1.9 1 1 1 2 2 2 0 Sigma-70 factor, region 1.1 DUF1985 PF09331.6 ESA04935.1 - 0.67 9.7 3.7 0.66 9.7 1.7 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF1985) DUF964 PF06133.6 ESA04936.1 - 0.084 12.8 2.6 0.088 12.8 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF964) DNA_repr_REX1B PF14966.1 ESA04936.1 - 0.1 12.9 1.9 0.14 12.5 0.9 1.5 1 1 0 1 1 1 0 DNA repair REX1-B Cep57_CLD_2 PF14197.1 ESA04936.1 - 0.15 11.9 3.6 0.086 12.7 1.1 1.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF3373 PF11853.3 ESA04936.1 - 0.17 10.3 1.8 0.24 9.8 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) UvrD-helicase PF00580.16 ESA04936.1 - 0.51 9.5 3.9 0.56 9.4 2.7 1.0 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain COG2 PF06148.6 ESA04936.1 - 1.4 8.7 5.4 3.3 7.6 3.6 1.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc42p PF11544.3 ESA04936.1 - 3.3 7.6 8.7 0.17 11.8 1.8 2.1 3 0 0 3 3 3 0 Spindle pole body component Spc42p TMF_DNA_bd PF12329.3 ESA04936.1 - 4 7.2 10.5 0.31 10.8 3.4 2.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF3847 PF12958.2 ESA04936.1 - 8.3 6.2 11.3 0.76 9.5 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) zf-Tim10_DDP PF02953.10 ESA04937.1 - 3.8e-25 86.9 2.1 5e-25 86.5 1.5 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3398 PF11878.3 ESA04937.1 - 0.0019 17.9 0.1 0.0022 17.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) DUF842 PF05811.8 ESA04937.1 - 0.11 11.9 3.9 0.2 11.1 2.7 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) ATP_bind_1 PF03029.12 ESA04938.1 - 2.7e-86 289.0 0.2 3.4e-86 288.6 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 ESA04938.1 - 9e-07 28.5 0.0 4.3e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.18 ESA04938.1 - 7.9e-05 22.1 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.1 ESA04938.1 - 9.7e-05 22.5 0.0 0.00052 20.1 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 ESA04938.1 - 0.00012 21.6 0.0 0.00016 21.1 0.0 1.3 1 1 0 1 1 1 1 AAA-like domain AAA_33 PF13671.1 ESA04938.1 - 0.00025 20.9 0.0 0.00052 19.8 0.0 1.7 2 1 0 2 2 1 1 AAA domain G-alpha PF00503.15 ESA04938.1 - 0.00055 18.7 0.2 0.048 12.3 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit SRP54 PF00448.17 ESA04938.1 - 0.00066 19.1 0.1 0.015 14.7 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain cobW PF02492.14 ESA04938.1 - 0.00093 18.6 0.0 1.2 8.5 0.0 2.5 2 1 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 ESA04938.1 - 0.0017 18.3 0.0 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 ESA04938.1 - 0.0017 19.1 0.0 0.0039 17.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain ArgK PF03308.11 ESA04938.1 - 0.0022 16.8 0.0 1.1 7.9 0.0 2.2 2 0 0 2 2 2 2 ArgK protein FeoB_N PF02421.13 ESA04938.1 - 0.0022 17.2 0.1 0.029 13.6 0.0 2.5 3 0 0 3 3 3 1 Ferrous iron transport protein B MMR_HSR1 PF01926.18 ESA04938.1 - 0.0022 17.9 0.1 0.0066 16.3 0.0 1.9 2 0 0 2 2 1 1 50S ribosome-binding GTPase NB-ARC PF00931.17 ESA04938.1 - 0.0043 15.9 0.0 0.027 13.3 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.1 ESA04938.1 - 0.0073 15.9 0.0 0.11 12.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Arf PF00025.16 ESA04938.1 - 0.0082 15.4 0.1 0.67 9.1 0.0 3.0 3 1 0 3 3 3 1 ADP-ribosylation factor family NACHT PF05729.7 ESA04938.1 - 0.015 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.7 ESA04938.1 - 0.018 14.1 0.0 0.036 13.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin PduV-EutP PF10662.4 ESA04938.1 - 0.032 13.7 0.0 0.29 10.6 0.0 2.5 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 ESA04938.1 - 0.038 13.6 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.9 ESA04938.1 - 0.049 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) UPF0079 PF02367.12 ESA04938.1 - 0.054 13.1 0.0 0.17 11.5 0.0 1.8 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_18 PF13238.1 ESA04938.1 - 0.058 13.7 0.0 0.18 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.1 ESA04938.1 - 0.063 12.8 0.0 0.17 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 ESA04938.1 - 0.11 11.4 0.0 0.58 9.0 0.0 2.2 1 1 0 1 1 1 0 KAP family P-loop domain FtsK_SpoIIIE PF01580.13 ESA04938.1 - 0.14 11.5 0.2 0.95 8.8 0.0 2.2 2 1 0 2 2 2 0 FtsK/SpoIIIE family SRF-TF PF00319.13 ESA04942.1 - 4.2e-23 80.3 0.2 6.5e-23 79.7 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDC45 PF02724.9 ESA04942.1 - 0.0069 14.4 2.1 0.0085 14.1 1.4 1.0 1 0 0 1 1 1 1 CDC45-like protein TFIIE-A_C-term PF11521.3 ESA04942.1 - 0.44 10.5 3.0 0.71 9.8 2.1 1.4 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha RPA_interact_M PF14767.1 ESA04943.1 - 0.0046 17.6 5.8 0.0066 17.1 1.4 2.2 2 0 0 2 2 2 1 Replication protein A interacting middle Fijivirus_P9-2 PF06837.6 ESA04944.1 - 5.7 6.0 9.5 6.1 5.9 6.6 1.2 1 0 0 1 1 1 0 Fijivirus P9-2 protein Pox_A9 PF04835.7 ESA04944.1 - 9.6 6.1 8.7 0.38 10.6 2.2 1.4 2 0 0 2 2 2 0 A9 protein conserved region RCC1_2 PF13540.1 ESA04945.1 - 5.9e-06 25.7 0.6 0.0047 16.5 0.1 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 ESA04945.1 - 7.1e-05 22.9 0.0 0.003 17.7 0.0 2.5 2 1 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat HMG_box PF00505.14 ESA04946.1 - 0.0085 16.3 1.0 0.02 15.1 0.7 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box DUF1473 PF07341.6 ESA04947.1 - 0.37 10.3 7.3 0.52 9.8 4.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1473) LicD PF04991.8 ESA04947.1 - 0.43 10.6 0.1 0.43 10.6 0.1 2.1 1 1 1 2 2 2 0 LicD family DUF3294 PF07957.6 ESA04949.1 - 5.9e-05 22.6 0.1 7.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) Got1 PF04178.7 ESA04953.1 - 0.0007 19.6 2.3 0.0012 18.9 1.6 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family FAD_binding_4 PF01565.18 ESA04955.1 - 0.02 14.3 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DDE_Tnp_ISAZ013 PF07592.6 ESA04956.1 - 2.4e-05 23.2 0.2 0.018 13.8 0.1 2.4 2 1 0 2 2 2 2 Rhodopirellula transposase DDE domain Dev_Cell_Death PF10539.4 ESA04956.1 - 0.078 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Development and cell death domain DDE_1 PF03184.14 ESA04959.1 - 5.3e-11 42.0 0.2 5.7e-11 41.9 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA04959.1 - 0.0036 17.0 0.1 0.0036 17.0 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF762 PF05555.6 ESA04960.1 - 0.027 13.6 0.0 0.029 13.6 0.0 1.1 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF762) bZIP_1 PF00170.16 ESA04961.1 - 2.3e-08 33.8 18.3 1.1e-07 31.7 9.5 2.3 1 1 1 2 2 2 1 bZIP transcription factor Ist1 PF03398.9 ESA04961.1 - 0.026 13.9 1.3 0.042 13.2 0.9 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway Glutaredoxin2_C PF04399.8 ESA04961.1 - 0.1 12.1 3.1 0.16 11.5 2.2 1.2 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain bZIP_2 PF07716.10 ESA04961.1 - 0.15 11.9 17.2 0.26 11.1 8.7 2.3 1 1 1 2 2 2 0 Basic region leucine zipper V_ATPase_I PF01496.14 ESA04961.1 - 0.58 7.9 3.3 0.72 7.6 2.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESA04961.1 - 0.62 9.0 6.8 0.82 8.6 4.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Bap31 PF05529.7 ESA04961.1 - 0.78 9.1 4.0 1.4 8.3 2.8 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like bZIP_Maf PF03131.12 ESA04961.1 - 1.4 9.2 10.3 2.9 8.2 7.2 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.10 ESA04961.1 - 4.7 6.7 8.9 5.6 6.5 5.2 1.8 1 1 0 1 1 1 0 Septum formation initiator Tmemb_40 PF10160.4 ESA04963.1 - 0.036 13.2 0.2 0.039 13.1 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein RSD-2 PF07547.8 ESA04964.1 - 1.8 8.7 7.5 0.79 9.9 2.2 2.6 2 0 0 2 2 2 0 RSD-2 N-terminal domain FKBP_C PF00254.23 ESA04965.1 - 3e-32 110.5 0.0 3.9e-32 110.1 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase IFN-gamma PF00714.12 ESA04967.1 - 0.064 13.0 0.6 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 Interferon gamma HMG_box PF00505.14 ESA04969.1 - 1.2e-05 25.5 2.5 2.5e-05 24.4 1.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA04969.1 - 0.0036 16.6 0.1 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 LicD PF04991.8 ESA04969.1 - 0.012 15.7 4.2 0.017 15.2 2.8 1.3 1 1 0 1 1 1 0 LicD family Baculo_PEP_C PF04513.7 ESA04969.1 - 0.042 13.6 0.5 0.076 12.8 0.1 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran PF00005.22 ESA04971.1 - 1.4e-14 54.5 0.0 2.1e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_ATPase PF09818.4 ESA04971.1 - 3.3e-06 25.9 0.0 3.9e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SMC_N PF02463.14 ESA04971.1 - 2.2e-05 23.8 0.0 2.7e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 ESA04971.1 - 0.0011 18.8 0.6 0.011 15.6 0.4 2.1 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Dala_Dala_lig_N PF01820.16 ESA04971.1 - 0.0039 17.4 0.0 0.0055 17.0 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase N-terminus AAA_21 PF13304.1 ESA04971.1 - 0.019 14.9 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain HLH PF00010.21 ESA04972.1 - 1.9e-14 53.0 1.4 4.1e-14 51.9 1.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HR1 PF02185.11 ESA04972.1 - 0.16 11.7 4.4 0.068 12.9 0.9 1.9 2 0 0 2 2 2 0 Hr1 repeat Arf PF00025.16 ESA04973.1 - 1.3e-47 161.3 0.0 1.7e-47 160.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESA04973.1 - 4.4e-13 48.9 0.0 7e-13 48.2 0.0 1.3 1 1 0 1 1 1 1 Ras family Miro PF08477.8 ESA04973.1 - 9.5e-12 45.4 0.0 1.7e-11 44.6 0.0 1.4 1 1 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 ESA04973.1 - 1.4e-11 43.7 0.1 6e-09 35.0 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESA04973.1 - 7.8e-11 41.5 0.0 1.1e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESA04973.1 - 5.9e-10 38.6 0.0 7.2e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA04973.1 - 1.3e-08 34.5 0.0 6.7e-07 28.9 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA04973.1 - 1.9e-07 31.0 0.0 3.2e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.1 ESA04973.1 - 0.00039 20.8 0.1 0.00053 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA04973.1 - 0.011 15.3 0.6 0.026 14.2 0.1 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 ESA04973.1 - 0.028 14.7 0.1 0.047 14.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.13 ESA04973.1 - 0.032 13.5 0.1 0.11 11.7 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B Imm31 PF15595.1 ESA04973.1 - 0.045 13.5 0.2 0.088 12.5 0.0 1.6 2 0 0 2 2 2 0 Immunity protein 31 cobW PF02492.14 ESA04973.1 - 0.058 12.8 0.6 7.9 5.8 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.4 ESA04973.1 - 0.12 11.8 0.3 4.1 6.8 0.0 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 ESA04973.1 - 0.16 11.8 0.4 1.8 8.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain TLD PF07534.11 ESA04974.1 - 0.00036 20.5 2.7 0.0012 18.8 1.9 1.7 1 1 0 1 1 1 1 TLD DUF2296 PF10058.4 ESA04975.1 - 0.074 12.8 0.4 0.17 11.6 0.3 1.6 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) Glyco_hydro_47 PF01532.15 ESA04976.1 - 1.4e-163 544.8 0.5 1.7e-163 544.4 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 KRTAP PF11759.3 ESA04978.1 - 0.0048 17.1 4.8 0.0048 17.1 3.3 1.8 2 0 0 2 2 2 1 Keratin-associated matrix DUF4134 PF13572.1 ESA04979.1 - 0.00039 20.4 0.6 1.7 8.8 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4134) Fer4_8 PF13183.1 ESA04979.1 - 0.0044 17.0 1.7 15 5.7 0.1 3.3 3 0 0 3 3 3 1 4Fe-4S dicluster domain DUF359 PF04019.7 ESA04979.1 - 0.007 15.7 0.5 35 3.8 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF359) Fer4_7 PF12838.2 ESA04979.1 - 0.0076 16.6 1.1 6.4 7.2 0.1 3.3 3 0 0 3 3 3 1 4Fe-4S dicluster domain TraT PF05818.7 ESA04979.1 - 0.044 13.1 0.4 4 6.7 0.0 2.6 3 0 0 3 3 3 0 Enterobacterial TraT complement resistance protein HBS1_N PF08938.5 ESA04979.1 - 0.39 10.8 2.0 22 5.2 0.1 2.9 3 0 0 3 3 3 0 HBS1 N-terminus CBM_5_12 PF02839.9 ESA04979.1 - 4.8 6.8 10.5 63 3.2 0.0 5.2 5 0 0 5 5 5 0 Carbohydrate binding domain SapB_2 PF03489.12 ESA04981.1 - 0.2 11.7 0.7 3.7 7.6 0.1 2.5 3 0 0 3 3 3 0 Saposin-like type B, region 2 Imm7 PF15588.1 ESA04982.1 - 0.013 15.5 0.6 0.014 15.4 0.4 1.2 1 0 0 1 1 1 0 Immunity protein 7 LRR_8 PF13855.1 ESA04983.1 - 1.4 8.7 7.4 4.1 7.2 0.1 3.5 3 1 0 3 3 3 0 Leucine rich repeat Cyclin_N PF00134.18 ESA04986.1 - 9.7e-50 167.3 1.0 5e-44 148.9 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESA04986.1 - 3.2e-34 117.3 2.6 6e-34 116.5 1.8 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Peroxin-3 PF04882.7 ESA04987.1 - 2.5e-63 214.3 7.4 3.7e-63 213.7 5.1 1.3 1 0 0 1 1 1 1 Peroxin-3 THRAP3_BCLAF1 PF15440.1 ESA04987.1 - 0.18 10.4 6.8 0.22 10.1 4.7 1.2 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Na_trans_assoc PF06512.8 ESA04987.1 - 0.21 11.5 9.4 0.35 10.8 6.5 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated PAP1 PF08601.5 ESA04987.1 - 0.42 10.2 18.0 0.58 9.7 12.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 DUF2201_N PF13203.1 ESA04987.1 - 0.82 8.7 4.2 1.7 7.7 2.5 1.7 1 1 1 2 2 2 0 Putative metallopeptidase domain POX PF07526.6 ESA04987.1 - 1.8 8.7 5.2 3.4 7.8 0.9 2.3 2 0 0 2 2 2 0 Associated with HOX Pkinase_Tyr PF07714.12 ESA04988.1 - 4.1e-42 144.0 0.0 5.7e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04988.1 - 3.9e-41 140.9 0.0 6.1e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA04988.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YyzF PF14116.1 ESA04988.1 - 0.42 10.5 3.0 16 5.5 0.5 3.1 3 0 0 3 3 3 0 YyzF-like protein TetM_leader PF08076.6 ESA04989.1 - 2.3 7.8 6.7 0.27 10.8 0.9 2.1 1 1 1 2 2 2 0 Tetracycline resistance determinant leader peptide DUF1785 PF08699.5 ESA04990.1 - 9.9e-06 24.8 0.1 1.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Peptidase_C14 PF00656.17 ESA04991.1 - 7.3e-25 88.0 0.1 8e-25 87.9 0.0 1.0 1 0 0 1 1 1 1 Caspase domain NAP PF00956.13 ESA04991.1 - 0.0043 16.2 0.1 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Pkinase_Tyr PF07714.12 ESA04992.1 - 5.9e-32 110.7 0.0 1e-31 110.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA04992.1 - 1.7e-29 102.7 0.0 2.7e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA04992.1 - 0.0007 18.6 0.0 0.00096 18.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA04992.1 - 0.0019 17.5 0.0 0.0036 16.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA04992.1 - 0.0023 17.0 0.1 0.0038 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA04992.1 - 0.0074 15.5 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA04992.1 - 0.01 15.6 0.5 0.021 14.5 0.3 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family PROCT PF08084.6 ESA04994.1 - 0.048 13.3 0.0 0.059 13.0 0.0 1.1 1 0 0 1 1 1 0 PROCT (NUC072) domain DUF2205 PF10224.4 ESA04996.1 - 0.029 13.9 0.1 0.052 13.1 0.1 1.4 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) Baculo_PEP_C PF04513.7 ESA04996.1 - 0.11 12.3 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sod_Cu PF00080.15 ESA04997.1 - 6.3e-35 120.3 1.2 2.5e-33 115.1 0.8 2.0 1 1 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) p450 PF00067.17 ESA04998.1 - 6.6e-15 54.5 0.0 7.9e-15 54.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.20 ESA05002.1 - 1e-37 129.7 0.3 5.9e-37 127.2 0.1 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05002.1 - 3.3e-37 127.9 0.0 4.8e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DZR PF12773.2 ESA05002.1 - 0.094 12.5 9.6 0.31 10.8 2.0 2.4 2 0 0 2 2 2 0 Double zinc ribbon NOB1_Zn_bind PF08772.6 ESA05002.1 - 0.11 12.2 6.7 0.93 9.3 1.0 2.6 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Cript PF10235.4 ESA05002.1 - 1.3 9.4 9.8 6.1 7.2 0.4 2.7 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT TMEM192 PF14802.1 ESA05004.1 - 0.069 12.0 0.5 0.098 11.4 0.4 1.2 1 0 0 1 1 1 0 TMEM192 family DUF4375 PF14300.1 ESA05004.1 - 0.093 12.7 4.0 0.12 12.3 0.1 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4375) Leu_Phe_trans PF03588.9 ESA05004.1 - 0.12 11.4 1.2 0.36 9.9 0.0 2.1 2 1 0 2 2 2 0 Leucyl/phenylalanyl-tRNA protein transferase Ret_tiss PF10044.4 ESA05004.1 - 0.85 10.1 4.3 3.5 8.2 0.0 2.8 2 2 1 3 3 3 0 Retinal tissue protein DNA_pol3_theta PF06440.6 ESA05005.1 - 0.045 13.3 0.3 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase III, theta subunit HEAT_2 PF13646.1 ESA05007.1 - 4.3e-14 52.5 0.1 0.00016 21.8 0.1 5.3 2 2 3 5 5 5 4 HEAT repeats Arm PF00514.18 ESA05007.1 - 1.7e-13 49.8 10.3 0.0083 15.9 0.0 7.0 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat UNC45-central PF11701.3 ESA05007.1 - 1.5e-11 44.2 17.2 2.8e-08 33.5 2.3 4.4 5 0 0 5 5 5 2 Myosin-binding striated muscle assembly central HEAT PF02985.17 ESA05007.1 - 6.1e-08 32.1 7.7 0.17 12.0 0.0 7.6 9 0 0 9 9 9 2 HEAT repeat DUF908 PF06012.7 ESA05007.1 - 0.00051 19.4 3.6 0.0035 16.7 0.1 3.4 4 0 0 4 4 4 1 Domain of Unknown Function (DUF908) HEAT_EZ PF13513.1 ESA05007.1 - 0.00088 19.6 0.8 56 4.3 0.0 5.8 7 1 0 7 7 7 0 HEAT-like repeat HEAT_PBS PF03130.11 ESA05007.1 - 0.21 12.1 1.4 2.2e+02 2.7 0.0 4.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.3 ESA05007.1 - 1.1 9.1 10.2 6.6 6.6 0.4 4.4 4 1 0 4 4 4 0 V-ATPase subunit H Polysacc_synt_4 PF04669.8 ESA05009.1 - 7.6e-15 54.7 1.3 5.4e-14 52.0 0.9 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis Na_K-ATPase PF00287.13 ESA05010.1 - 0.16 10.7 0.3 0.2 10.3 0.2 1.1 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain ABC_tran PF00005.22 ESA05011.1 - 0.00045 20.5 0.0 0.00068 19.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter YukC PF10140.4 ESA05011.1 - 0.0016 17.1 0.3 0.0019 16.8 0.2 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC AAA_29 PF13555.1 ESA05011.1 - 0.0032 16.9 0.2 0.0056 16.1 0.2 1.5 1 1 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESA05011.1 - 0.0037 16.4 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA05011.1 - 0.0055 15.8 0.0 0.007 15.4 0.0 1.1 1 0 0 1 1 1 1 AIG1 family AAA_16 PF13191.1 ESA05011.1 - 0.017 15.0 0.0 0.021 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 ESA05011.1 - 0.026 14.8 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA05011.1 - 0.035 14.2 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESA05011.1 - 0.04 13.8 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.8 ESA05011.1 - 0.052 12.4 0.0 0.079 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 ESA05011.1 - 0.056 12.5 0.1 0.09 11.8 0.0 1.4 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 ESA05011.1 - 0.067 14.0 0.0 0.096 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain HATPase_c_3 PF13589.1 ESA05012.1 - 1.8e-11 43.8 0.0 4.1e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA05012.1 - 9.4e-06 25.3 0.0 2.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSDR_N_2 PF13588.1 ESA05012.1 - 0.00051 19.8 0.1 0.0014 18.3 0.1 1.7 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) HTH_44 PF14641.1 ESA05012.1 - 0.0024 17.8 0.1 0.0075 16.2 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 MACPF PF01823.14 ESA05014.1 - 2e-06 27.6 0.0 2.7e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 MAC/Perforin domain CDC37_C PF08564.5 ESA05014.1 - 0.12 12.2 0.2 1 9.2 0.0 2.2 2 0 0 2 2 2 0 Cdc37 C terminal domain TLD PF07534.11 ESA05015.1 - 2.1e-11 43.9 4.8 3.4e-11 43.2 3.3 1.4 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA05015.1 - 2.5e-11 43.5 0.1 2.1e-10 40.5 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA05015.1 - 3.7e-07 29.9 0.0 6.9e-06 25.8 0.0 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Big_5 PF13205.1 ESA05016.1 - 0.0013 19.2 0.2 0.0032 18.0 0.1 1.6 1 0 0 1 1 1 1 Bacterial Ig-like domain AAA_assoc_C PF09821.4 ESA05016.1 - 0.16 12.2 0.0 0.36 11.1 0.0 1.5 2 0 0 2 2 2 0 C-terminal AAA-associated domain ICAT PF06384.6 ESA05019.1 - 0.16 11.7 0.5 0.24 11.1 0.4 1.5 1 1 0 1 1 1 0 Beta-catenin-interacting protein ICAT DUF883 PF05957.8 ESA05021.1 - 4.9 7.6 5.7 9.2 6.7 3.3 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Spc7 PF08317.6 ESA05022.1 - 0.085 11.5 3.5 0.13 10.9 2.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FLYWCH PF04500.11 ESA05022.1 - 0.34 10.8 1.7 0.62 10.0 0.4 2.0 2 0 0 2 2 2 0 FLYWCH zinc finger domain IncA PF04156.9 ESA05022.1 - 1.1 8.8 2.8 1.7 8.2 1.9 1.2 1 0 0 1 1 1 0 IncA protein Sterile PF03015.14 ESA05024.1 - 0.0047 17.1 0.2 0.0061 16.8 0.2 1.3 1 0 0 1 1 1 1 Male sterility protein DUF1548 PF07579.6 ESA05024.1 - 0.011 15.8 0.9 0.014 15.4 0.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) FHIPEP PF00771.15 ESA05024.1 - 0.016 13.5 0.2 0.019 13.3 0.1 1.0 1 0 0 1 1 1 0 FHIPEP family DUF3546 PF12066.3 ESA05024.1 - 0.049 13.6 1.8 0.082 12.9 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3546) DUF1642 PF07852.6 ESA05024.1 - 0.089 13.1 1.4 0.1 12.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1642) Peptidase_S41 PF03572.13 ESA05024.1 - 0.096 12.0 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase family S41 S4 PF01479.20 ESA05025.1 - 0.01 15.2 0.1 0.02 14.3 0.1 1.5 1 0 0 1 1 1 0 S4 domain DUF3990 PF13151.1 ESA05026.1 - 1.3e-05 24.6 0.0 2.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) RB_A PF01858.12 ESA05027.1 - 0.093 12.3 0.2 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain Pkinase_Tyr PF07714.12 ESA05029.1 - 0.013 14.5 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Sec7 PF01369.15 ESA05029.1 - 0.047 13.3 0.7 0.09 12.4 0.4 1.5 1 1 0 1 1 1 0 Sec7 domain Pkinase PF00069.20 ESA05029.1 - 0.097 11.8 0.0 0.18 10.9 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain MACPF PF01823.14 ESA05030.1 - 9.1e-07 28.7 2.9 1.7e-05 24.6 2.0 2.3 1 1 0 1 1 1 1 MAC/Perforin domain CtIP_N PF10482.4 ESA05032.1 - 0.0076 16.0 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain DUF506 PF04720.7 ESA05033.1 - 0.41 10.2 8.3 0.6 9.7 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF506) Pkinase_Tyr PF07714.12 ESA05034.1 - 1.8e-43 148.5 0.1 4.2e-43 147.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05034.1 - 1.7e-42 145.3 0.2 3e-42 144.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain YchF-GTPase_C PF06071.8 ESA05034.1 - 0.065 13.0 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF933) DUF3741 PF12552.3 ESA05036.1 - 0.067 12.9 2.0 16 5.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3741) DUF3952 PF13130.1 ESA05039.1 - 0.018 14.9 0.3 0.028 14.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3952) Trypan_PARP PF05887.6 ESA05039.1 - 0.55 10.0 19.2 0.86 9.4 13.3 1.4 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.7 ESA05039.1 - 6.1 6.1 10.1 8.8 5.6 7.0 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) vATP-synt_E PF01991.13 ESA05040.1 - 0.15 11.3 2.0 1.7 7.9 0.4 2.3 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit MFS_1 PF07690.11 ESA05041.1 - 1.3e-33 116.2 4.9 1.6e-33 115.9 3.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.2 ESA05041.1 - 0.011 15.5 0.3 0.046 13.5 0.2 2.1 1 0 0 1 1 1 0 MFS_1 like family CsbD PF05532.7 ESA05042.1 - 1.6e-26 91.7 17.6 4.2e-10 39.1 0.3 3.0 2 1 1 3 3 3 3 CsbD-like MT0933_antitox PF14013.1 ESA05042.1 - 0.16 12.1 2.0 14 5.8 0.1 2.5 2 0 0 2 2 2 0 MT0933-like antitoxin protein HAUS4 PF14735.1 ESA05044.1 - 0.051 12.8 0.1 2.3 7.4 0.0 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 MRAP PF15183.1 ESA05047.1 - 0.16 11.5 0.8 0.3 10.6 0.3 1.6 1 1 1 2 2 2 0 Melanocortin-2 receptor accessory protein family PDDEXK_2 PF12784.2 ESA05048.1 - 0.45 9.6 6.4 4.8 6.2 0.5 2.4 2 1 0 2 2 2 0 PD-(D/E)XK nuclease family transposase Myb_DNA-bind_6 PF13921.1 ESA05049.1 - 2.4e-06 27.5 2.1 2.4e-06 27.5 1.5 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA05049.1 - 2.1e-05 24.4 0.0 5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF1399 PF07173.7 ESA05050.1 - 1.4e-19 70.7 0.4 3.1e-19 69.6 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1399) DUF1870 PF08965.5 ESA05051.1 - 0.023 14.3 0.1 0.027 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) IstB_IS21 PF01695.12 ESA05053.1 - 0.014 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 ESA05053.1 - 0.049 12.7 0.1 0.093 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC Metallothio PF00131.15 ESA05053.1 - 0.36 10.7 18.3 0.66 9.8 12.7 1.4 1 0 0 1 1 1 0 Metallothionein Dna2 PF08696.6 ESA05054.1 - 0.087 12.1 0.4 0.11 11.7 0.3 1.2 1 0 0 1 1 1 0 DNA replication factor Dna2 YaaC PF14175.1 ESA05054.1 - 0.098 11.6 5.9 0.12 11.3 3.5 1.5 1 1 1 2 2 2 0 YaaC-like Protein MSP7_C PF12948.2 ESA05054.1 - 1.3 9.2 10.2 1.2 9.3 6.0 1.7 1 1 1 2 2 2 0 MSP7-like protein C-terminal domain Aldo_ket_red PF00248.16 ESA05055.1 - 1e-78 264.0 0.0 1.1e-78 263.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AAA_28 PF13521.1 ESA05055.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain FBPase PF00316.15 ESA05057.1 - 1.1e-123 412.2 0.1 1.2e-123 412.0 0.1 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 ESA05057.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family Med22 PF06179.7 ESA05059.1 - 3.3e-17 62.4 4.6 4.5e-17 62.0 3.2 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Kelch_5 PF13854.1 ESA05061.1 - 0.01 15.8 0.1 0.027 14.4 0.0 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.1 ESA05061.1 - 0.027 14.6 0.2 0.36 11.0 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain GST_N_3 PF13417.1 ESA05062.1 - 8.7e-18 64.3 0.0 9.6e-18 64.1 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA05062.1 - 1.2e-14 54.1 0.0 1.4e-14 53.9 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA05062.1 - 4.9e-12 45.6 0.0 5.5e-12 45.5 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.4 ESA05062.1 - 0.098 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Pkinase_Tyr PF07714.12 ESA05063.1 - 0.0004 19.5 0.0 0.00094 18.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05063.1 - 0.048 12.7 0.1 0.13 11.3 0.0 1.7 1 1 0 2 2 2 0 Protein kinase domain DUF2791 PF10923.3 ESA05063.1 - 0.1 11.1 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) NTS PF15447.1 ESA05064.1 - 0.03 14.6 0.1 0.03 14.6 0.1 2.6 2 0 0 2 2 2 0 N-terminal segments of PfEMP1 DUF4611 PF15387.1 ESA05064.1 - 2.1 8.5 8.2 6.1 7.0 3.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3452 PF11934.3 ESA05064.1 - 6.1 6.1 11.2 25 4.1 5.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3452) ALMT PF11744.3 ESA05064.1 - 8.5 4.9 11.1 0.85 8.2 0.7 2.2 1 1 0 2 2 2 0 Aluminium activated malate transporter ApoLp-III PF07464.6 ESA05065.1 - 1 9.3 3.7 21 5.0 0.2 2.7 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) BNIP2 PF12496.3 ESA05066.1 - 0.018 15.2 0.9 0.023 14.8 0.6 1.1 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 P2_Phage_GpR PF06891.6 ESA05066.1 - 0.12 12.2 0.2 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 P2 phage tail completion protein R (GpR) DUF4119 PF13494.1 ESA05068.1 - 0.047 13.6 0.5 0.2 11.6 0.4 2.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF4119) Peptidase_C97 PF05903.9 ESA05068.1 - 0.083 12.6 2.1 0.82 9.4 0.4 2.3 2 0 0 2 2 2 0 PPPDE putative peptidase domain Pkinase_Tyr PF07714.12 ESA05069.1 - 1.7e-06 27.3 0.0 2.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05069.1 - 0.00013 21.2 0.1 0.00043 19.5 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain DUF1870 PF08965.5 ESA05069.1 - 0.4 10.3 2.2 0.53 9.9 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1870) BTB PF00651.26 ESA05073.1 - 2.8e-05 24.0 0.0 4.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Nucleoplasmin PF03066.10 ESA05073.1 - 0.43 10.0 3.7 0.63 9.5 2.5 1.2 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 ESA05073.1 - 5.5 7.3 12.8 8.9 6.7 8.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.20 ESA05074.1 - 8.3e-22 77.5 0.3 1.1e-21 77.1 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05074.1 - 9.6e-18 64.1 0.0 1.1e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_S2 PF00318.15 ESA05074.1 - 0.0068 15.6 0.3 0.0094 15.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S2 USP7_C2 PF14533.1 ESA05078.1 - 7.2e-56 188.9 18.3 3.7e-53 180.1 6.6 2.4 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.3 ESA05078.1 - 3.9e-51 173.7 8.1 1.2e-26 93.5 0.2 3.3 2 1 1 3 3 3 3 ICP0-binding domain of Ubiquitin-specific protease 7 UN_NPL4 PF11543.3 ESA05078.1 - 0.0052 17.0 0.6 0.22 11.8 0.0 3.7 3 0 0 3 3 3 1 Nuclear pore localisation protein NPL4 p450 PF00067.17 ESA05079.1 - 1.5e-50 172.0 0.0 2e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FATC PF02260.15 ESA05081.1 - 9.6e-15 53.7 0.1 1.9e-14 52.8 0.1 1.5 1 0 0 1 1 1 1 FATC domain Hist_deacetyl PF00850.14 ESA05082.1 - 5.9e-79 265.5 0.0 8e-79 265.1 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Proteasome PF00227.21 ESA05083.1 - 6.5e-52 175.5 0.0 7.8e-52 175.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA05083.1 - 4.3e-12 45.1 0.0 8.2e-12 44.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TRM PF02005.11 ESA05084.1 - 5.7e-131 436.8 1.7 6.9e-131 436.6 1.2 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_31 PF13847.1 ESA05084.1 - 4.1e-05 23.1 0.1 0.0001 21.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.11 ESA05084.1 - 8.9e-05 22.1 0.1 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.9 ESA05084.1 - 0.0016 17.8 0.1 0.0043 16.4 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.10 ESA05084.1 - 0.0034 16.8 0.0 0.009 15.4 0.0 1.5 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_26 PF13659.1 ESA05084.1 - 0.007 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESA05084.1 - 0.082 12.0 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AF1Q PF15017.1 ESA05086.1 - 0.24 11.3 3.9 0.28 11.0 2.7 1.1 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator Spore_GerQ PF09671.5 ESA05088.1 - 0.088 12.4 0.3 16 5.2 0.0 2.4 2 0 0 2 2 2 0 Spore coat protein (Spore_GerQ) RelA_SpoT PF04607.12 ESA05088.1 - 9.2 6.3 7.7 8.1 6.4 0.1 2.8 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins DUF3371 PF11851.3 ESA05089.1 - 0.024 15.3 2.4 0.027 15.1 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) ACDC PF14733.1 ESA05090.1 - 0.066 13.3 0.1 0.097 12.8 0.1 1.2 1 0 0 1 1 1 0 AP2-coincident C-terminal BTB PF00651.26 ESA05092.1 - 6.3e-14 51.8 0.9 8.3e-13 48.2 0.0 2.6 2 1 1 3 3 3 1 BTB/POZ domain Helicase_C PF00271.26 ESA05093.1 - 5.7e-21 74.1 0.5 1.3e-16 60.2 0.0 2.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain SpoU_sub_bind PF08032.7 ESA05093.1 - 0.00065 19.8 0.0 0.026 14.6 0.0 2.6 3 0 0 3 3 3 1 RNA 2'-O ribose methyltransferase substrate binding DEAD PF00270.24 ESA05093.1 - 0.02 14.3 0.1 0.049 13.1 0.0 1.6 1 1 1 2 2 2 0 DEAD/DEAH box helicase PS_Dcarbxylase PF02666.10 ESA05093.1 - 0.11 11.8 0.1 7.7 5.7 0.0 2.1 1 1 1 2 2 2 0 Phosphatidylserine decarboxylase MazG-like PF12643.2 ESA05093.1 - 0.12 12.2 0.2 0.28 11.1 0.1 1.6 2 0 0 2 2 2 0 MazG-like family Ion_trans PF00520.26 ESA05095.1 - 0.066 12.4 2.2 0.075 12.2 1.5 1.1 1 0 0 1 1 1 0 Ion transport protein UbiA PF01040.13 ESA05095.1 - 0.074 12.2 0.3 0.073 12.2 0.2 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family Lipase_GDSL_3 PF14606.1 ESA05096.1 - 8.9 6.0 8.8 17 5.0 0.5 2.5 2 1 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family F-box-like PF12937.2 ESA05101.1 - 0.00043 19.9 0.5 0.00075 19.1 0.2 1.5 2 0 0 2 2 2 1 F-box-like ComX PF05952.7 ESA05102.1 - 0.0058 16.1 2.6 0.013 14.9 0.3 2.2 1 1 1 2 2 2 1 Bacillus competence pheromone ComX TetR_C_8 PF14278.1 ESA05102.1 - 3.5 8.0 9.8 2.6 8.4 0.9 3.2 1 1 3 4 4 4 0 Transcriptional regulator C-terminal region WIYLD PF10440.4 ESA05103.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain ABC_tran PF00005.22 ESA05105.1 - 5.1e-36 123.9 0.0 1e-35 122.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESA05105.1 - 5.8e-09 35.5 0.3 7.6e-07 28.5 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA05105.1 - 2.9e-07 30.7 0.5 0.0013 18.7 0.4 2.2 1 1 1 2 2 2 2 AAA domain AAA_29 PF13555.1 ESA05105.1 - 0.0002 20.7 0.2 0.00054 19.4 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 ESA05105.1 - 0.00037 19.7 0.0 0.00063 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESA05105.1 - 0.0014 18.6 0.3 0.0051 16.8 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA05105.1 - 0.0023 18.0 0.1 0.017 15.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA05105.1 - 0.0036 17.4 0.0 0.051 13.7 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA05105.1 - 0.0041 17.9 0.1 0.0077 17.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA05105.1 - 0.0079 16.4 0.0 0.024 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 ESA05105.1 - 0.013 14.9 0.2 0.1 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain AAA_5 PF07728.9 ESA05105.1 - 0.017 14.8 0.1 0.16 11.6 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA05105.1 - 0.021 14.6 0.1 0.12 12.2 0.0 2.2 1 1 0 1 1 1 0 AAA domain Guanylate_kin PF00625.16 ESA05105.1 - 0.026 13.9 2.1 0.089 12.2 0.2 2.4 2 1 0 2 2 2 0 Guanylate kinase AAA_28 PF13521.1 ESA05105.1 - 0.028 14.4 0.1 0.22 11.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 ESA05105.1 - 0.031 14.1 3.3 0.19 11.6 0.2 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.4 ESA05105.1 - 0.053 12.0 0.1 0.98 7.9 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class APS_kinase PF01583.15 ESA05105.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF3808 PF10300.4 ESA05106.1 - 7.8e-41 140.1 0.2 1.4e-40 139.3 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) SOBP PF15279.1 ESA05108.1 - 2.9 8.1 13.7 0.57 10.5 5.4 2.0 2 0 0 2 2 2 0 Sine oculis-binding protein Tir_receptor_N PF07490.6 ESA05108.1 - 4 6.9 10.2 0.39 10.2 3.0 2.0 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) N-terminus ATP-synt_8 PF00895.15 ESA05109.1 - 0.23 11.7 7.5 3.7 7.8 0.0 3.2 3 0 0 3 3 3 0 ATP synthase protein 8 EBP PF05241.7 ESA05109.1 - 0.78 8.7 5.4 0.2 10.6 1.1 1.8 2 0 0 2 2 2 0 Emopamil binding protein DUF328 PF03883.9 ESA05111.1 - 0.0066 15.7 0.1 0.0083 15.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF328) HGTP_anticodon2 PF12745.2 ESA05111.1 - 0.11 11.6 1.4 0.13 11.4 1.0 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs ARL2_Bind_BART PF11527.3 ESA05111.1 - 0.14 11.9 1.7 0.21 11.4 1.1 1.3 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART PMI_typeI PF01238.16 ESA05112.1 - 2.4e-132 441.4 0.0 2.8e-132 441.2 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.6 ESA05112.1 - 0.0057 16.1 0.0 0.5 9.9 0.0 2.2 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.14 ESA05112.1 - 0.01 15.5 0.0 0.86 9.2 0.0 2.8 3 0 0 3 3 3 1 AraC-like ligand binding domain FATC PF02260.15 ESA05112.1 - 0.028 13.8 0.1 0.054 12.9 0.1 1.5 1 0 0 1 1 1 0 FATC domain Carn_acyltransf PF00755.15 ESA05113.1 - 5.4e-63 213.0 0.0 6e-63 212.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase SMN PF06003.7 ESA05115.1 - 0.083 11.9 0.1 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Big_5 PF13205.1 ESA05116.1 - 0.0059 17.1 0.4 0.013 16.1 0.3 1.5 1 0 0 1 1 1 1 Bacterial Ig-like domain CsbD PF05532.7 ESA05117.1 - 1.5e-22 79.0 21.8 6.9e-11 41.6 3.3 3.1 2 1 1 3 3 3 3 CsbD-like Pneumo_att_G PF05539.6 ESA05117.1 - 7.4 5.8 8.0 8.4 5.6 5.6 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Alpha_E3_glycop PF01563.11 ESA05119.1 - 0.067 13.0 0.1 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 Alphavirus E3 glycoprotein Bestrophin PF01062.16 ESA05120.1 - 9.5e-13 47.7 0.0 1e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Pkinase_Tyr PF07714.12 ESA05121.1 - 6.5e-23 81.1 0.1 1.1e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05121.1 - 1.5e-22 79.9 1.0 2.3e-22 79.3 0.7 1.3 1 0 0 1 1 1 1 Protein kinase domain Imm46 PF15585.1 ESA05121.1 - 0.0096 15.9 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 1 Immunity protein 46 zf-CHCC PF10276.4 ESA05121.1 - 0.029 14.2 0.4 0.029 14.2 0.3 3.3 3 0 0 3 3 3 0 Zinc-finger domain YchF-GTPase_C PF06071.8 ESA05121.1 - 0.04 13.6 0.5 0.36 10.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF933) Kdo PF06293.9 ESA05121.1 - 0.097 11.7 1.2 0.13 11.3 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA05121.1 - 0.14 11.8 0.3 1 9.0 0.4 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Methyltransf_31 PF13847.1 ESA05127.1 - 3.1e-10 39.8 0.0 1.5e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA05127.1 - 7.2e-10 39.2 0.0 1e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA05127.1 - 3.5e-08 33.7 0.0 5.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA05127.1 - 8.3e-07 28.8 0.0 1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA05127.1 - 2.8e-06 26.8 0.0 3.6e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA05127.1 - 3.2e-06 27.1 0.0 9.1e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA05127.1 - 2.2e-05 23.6 0.0 0.00039 19.6 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA05127.1 - 2.3e-05 24.9 0.0 8.3e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA05127.1 - 0.00079 19.8 0.0 0.002 18.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA05127.1 - 0.033 13.2 0.0 0.047 12.7 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase TehB PF03848.9 ESA05127.1 - 0.044 12.9 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.9 ESA05127.1 - 0.091 12.1 0.0 0.22 10.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Peptidase_S8 PF00082.17 ESA05128.1 - 1e-46 159.3 5.4 1.2e-46 159.1 3.7 1.0 1 0 0 1 1 1 1 Subtilase family Peptidase_S10 PF00450.17 ESA05128.1 - 0.032 13.4 0.1 0.038 13.1 0.1 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase LAMTOR PF15454.1 ESA05130.1 - 0.29 11.4 4.6 0.92 9.8 3.2 1.8 1 1 0 1 1 1 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator LRR_4 PF12799.2 ESA05131.1 - 0.46 10.1 12.4 0.49 10.0 2.1 4.8 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) TFIIE_beta PF02186.10 ESA05132.1 - 0.47 10.4 2.6 0.73 9.8 0.1 2.3 2 0 0 2 2 2 0 TFIIE beta subunit core domain HMG_box PF00505.14 ESA05134.1 - 5.2e-05 23.4 1.4 8.4e-05 22.7 0.9 1.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA05134.1 - 0.00057 20.2 0.1 0.00074 19.8 0.1 1.2 1 0 0 1 1 1 1 HMG-box domain TCTP PF00838.12 ESA05136.1 - 2e-55 187.2 4.5 2.3e-55 187.0 3.1 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF3630 PF12305.3 ESA05136.1 - 0.02 14.7 0.1 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3630) Tho2 PF11262.3 ESA05136.1 - 0.044 12.8 1.1 0.053 12.5 0.8 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Yippee-Mis18 PF03226.9 ESA05137.1 - 3.4e-11 43.0 0.1 1.2e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PspB PF06667.7 ESA05137.1 - 0.12 12.3 0.1 0.19 11.7 0.1 1.2 1 0 0 1 1 1 0 Phage shock protein B TPR_2 PF07719.12 ESA05138.1 - 2.5e-12 45.7 0.8 7.6e-05 22.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA05138.1 - 4.3e-12 45.5 2.3 6.9e-12 44.8 0.5 2.1 2 1 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 ESA05138.1 - 1.6e-10 40.0 0.8 1.5e-05 24.3 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA05138.1 - 1e-09 38.1 0.3 0.00012 22.3 0.1 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA05138.1 - 1.2e-09 37.9 0.2 5.1e-05 23.5 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA05138.1 - 2.9e-09 37.3 3.1 6.4e-06 26.6 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA05138.1 - 1.3e-08 35.0 0.4 2.2e-08 34.3 0.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA05138.1 - 3.3e-07 29.9 1.0 2.2e-05 24.3 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA05138.1 - 9.7e-06 25.0 0.3 0.063 13.0 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA05138.1 - 9.9e-06 25.3 0.1 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA05138.1 - 3.6e-05 23.8 0.7 0.0039 17.2 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 ESA05138.1 - 8.3e-05 22.4 0.4 0.00085 19.2 0.3 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA05138.1 - 0.0012 18.5 0.8 2.3 8.2 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA05138.1 - 0.0038 17.2 4.1 0.033 14.2 2.8 2.2 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA05138.1 - 0.01 14.8 3.1 0.012 14.6 1.1 1.7 1 1 1 2 2 2 0 Tetratricopeptide repeat I_LWEQ PF01608.12 ESA05138.1 - 0.052 13.4 2.8 0.041 13.8 0.6 1.7 1 1 1 2 2 2 0 I/LWEQ domain Fis1_TPR_C PF14853.1 ESA05138.1 - 0.079 12.8 1.8 3.1 7.7 0.0 3.0 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF4629 PF15442.1 ESA05138.1 - 4.3 7.4 12.3 10 6.2 8.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4629) F-112 PF09645.5 ESA05138.1 - 5.1 7.0 7.0 5.1 7.0 0.4 2.4 2 1 0 2 2 2 0 F-112 protein DUF4451 PF14616.1 ESA05141.1 - 0.045 13.5 0.2 0.075 12.7 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) zf-BED PF02892.10 ESA05141.1 - 0.12 12.1 2.5 0.18 11.5 0.1 2.1 2 0 0 2 2 2 0 BED zinc finger DUF4475 PF14753.1 ESA05142.1 - 0.05 13.0 0.4 0.05 13.0 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4475) MARVEL PF01284.18 ESA05144.1 - 0.0069 16.2 0.0 0.0091 15.8 0.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF3955 PF13127.1 ESA05144.1 - 3.1 7.4 5.4 0.5 9.9 0.8 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3955) RNA_pol_Rpb4 PF03874.11 ESA05145.1 - 0.056 13.4 0.8 0.14 12.2 0.5 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb4 HSP70 PF00012.15 ESA05147.1 - 0.063 11.1 0.0 0.2 9.5 0.0 1.8 2 0 0 2 2 2 0 Hsp70 protein DUF2805 PF10985.3 ESA05149.1 - 0.033 14.1 0.3 11 6.1 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2805) DUF4422 PF14393.1 ESA05150.1 - 0.014 15.0 0.9 0.016 14.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) LMSTEN PF07988.7 ESA05150.1 - 0.02 14.1 1.6 1.7 8.0 0.0 2.4 2 0 0 2 2 2 0 LMSTEN motif DUF3829 PF12889.2 ESA05150.1 - 0.034 13.3 3.2 1.1 8.3 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) Monellin PF09200.5 ESA05150.1 - 0.04 13.5 0.3 8.8 6.0 0.0 2.6 2 0 0 2 2 2 0 Monellin EFP PF01132.15 ESA05150.1 - 0.065 12.9 2.6 1.8 8.2 0.3 2.5 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain PRP38 PF03371.10 ESA05150.1 - 0.085 12.4 1.3 5.3 6.6 0.1 2.0 1 1 1 2 2 2 0 PRP38 family Casc1 PF12366.3 ESA05150.1 - 0.14 11.6 3.6 2.8 7.3 0.3 2.0 1 1 1 2 2 2 0 Cancer susceptibility candidate 1 TcpQ PF10671.4 ESA05151.1 - 0.055 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Toxin co-regulated pilus biosynthesis protein Q Pkinase PF00069.20 ESA05152.1 - 3.2e-71 239.5 0.0 3.9e-71 239.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05152.1 - 1.8e-36 125.5 0.0 2.4e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA05152.1 - 2.4e-07 30.0 0.0 6.1e-07 28.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like T6SS-SciN PF12790.2 ESA05153.1 - 0.029 13.9 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 Type VI secretion lipoprotein Polyketide_cyc2 PF10604.4 ESA05156.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport WD40 PF00400.27 ESA05159.1 - 3.3e-40 134.5 15.1 1.3e-10 40.7 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 ESA05159.1 - 9.7e-06 23.9 0.1 0.098 10.7 0.1 3.4 1 1 3 4 4 4 2 Nucleoporin Nup120/160 LisH PF08513.6 ESA05159.1 - 0.01 15.5 0.1 0.039 13.7 0.0 2.0 2 0 0 2 2 2 0 LisH eIF2A PF08662.6 ESA05159.1 - 0.01 15.5 0.1 1 9.0 0.0 3.1 2 1 2 4 4 4 0 Eukaryotic translation initiation factor eIF2A Hira PF07569.6 ESA05159.1 - 0.014 14.6 0.0 0.67 9.1 0.0 3.2 4 0 0 4 4 4 0 TUP1-like enhancer of split PQQ_2 PF13360.1 ESA05159.1 - 0.06 12.8 0.0 0.84 9.0 0.0 2.4 1 1 1 2 2 2 0 PQQ-like domain PQQ_3 PF13570.1 ESA05159.1 - 0.068 13.4 0.0 0.36 11.1 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain PD40 PF07676.7 ESA05159.1 - 0.12 12.0 0.0 2.7 7.7 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Pkinase PF00069.20 ESA05167.1 - 7.2e-27 94.1 0.0 8e-27 94.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05167.1 - 2.5e-25 89.0 0.0 2.8e-25 88.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA05167.1 - 0.00072 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA05167.1 - 0.012 14.8 0.3 0.016 14.4 0.2 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA05167.1 - 0.028 13.7 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Dynein_heavy PF03028.10 ESA05170.1 - 0.02 12.9 0.3 0.023 12.7 0.2 1.1 1 0 0 1 1 1 0 Dynein heavy chain and region D6 of dynein motor F-box-like PF12937.2 ESA05171.1 - 0.0018 17.9 1.5 0.0037 16.9 1.0 1.5 1 0 0 1 1 1 1 F-box-like D5_N PF08706.6 ESA05173.1 - 0.087 12.9 0.9 2 8.5 0.1 2.1 2 0 0 2 2 2 0 D5 N terminal like DUF708 PF05341.6 ESA05174.1 - 0.054 13.2 0.3 0.17 11.6 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF708) Cullin PF00888.17 ESA05175.1 - 6.9e-92 308.8 9.9 9.1e-92 308.4 6.8 1.0 1 0 0 1 1 1 1 Cullin family BLOC1_2 PF10046.4 ESA05176.1 - 0.038 14.1 3.2 0.043 13.9 1.3 1.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.3 ESA05176.1 - 0.069 12.9 3.2 0.15 11.9 0.7 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding CCDC-167 PF15188.1 ESA05176.1 - 0.099 12.5 2.3 0.2 11.6 1.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF848 PF05852.6 ESA05176.1 - 0.19 11.5 4.7 0.047 13.5 1.1 1.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch PF05377.6 ESA05176.1 - 0.27 11.1 1.6 15 5.5 0.2 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.7 ESA05176.1 - 0.57 10.4 2.6 0.85 9.9 0.4 2.1 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein HR1 PF02185.11 ESA05176.1 - 7.2 6.4 8.0 8.1 6.2 1.3 2.7 2 1 1 3 3 3 0 Hr1 repeat Sel1 PF08238.7 ESA05178.1 - 1.4e-09 38.2 3.7 2.4e-07 31.1 1.1 2.6 2 0 0 2 2 2 2 Sel1 repeat Menin PF05053.8 ESA05178.1 - 1.2 7.2 7.3 2 6.4 5.1 1.4 1 0 0 1 1 1 0 Menin RRM_1 PF00076.17 ESA05181.1 - 5.4e-14 51.5 0.0 1e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA05181.1 - 5.1e-07 29.5 0.0 9.2e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA05181.1 - 0.0005 19.8 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4611 PF15387.1 ESA05182.1 - 0.063 13.4 0.5 0.071 13.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.1 ESA05182.1 - 0.072 13.3 0.6 0.085 13.1 0.4 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ebola_NP PF05505.7 ESA05182.1 - 0.34 8.9 2.3 0.38 8.7 1.6 1.0 1 0 0 1 1 1 0 Ebola nucleoprotein DUF3245 PF11595.3 ESA05182.1 - 0.42 10.8 2.0 0.52 10.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Kelch_3 PF13415.1 ESA05183.1 - 4e-11 42.7 7.6 0.0003 20.8 0.1 4.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA05183.1 - 2.4e-09 36.9 1.8 0.012 15.5 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA05183.1 - 2.2e-08 33.7 8.5 0.00023 20.8 0.0 4.8 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA05183.1 - 2.9e-05 24.0 12.7 0.096 12.9 0.0 5.1 3 1 2 5 5 5 2 Kelch motif Kelch_2 PF07646.10 ESA05183.1 - 9.7e-05 21.9 1.4 4.2 7.3 0.0 4.1 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA05183.1 - 0.17 11.4 8.0 9 5.9 0.0 4.6 5 0 0 5 5 5 0 Kelch motif Sel1 PF08238.7 ESA05184.1 - 5e-10 39.6 1.1 7.6e-06 26.3 0.0 3.5 3 1 0 3 3 3 3 Sel1 repeat N6_Mtase PF02384.11 ESA05187.1 - 0.016 14.3 1.0 0.019 14.0 0.7 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase RPA_interact_M PF14767.1 ESA05187.1 - 9.9 6.9 10.4 49 4.7 7.2 2.0 1 1 0 1 1 1 0 Replication protein A interacting middle HAD_2 PF13419.1 ESA05188.1 - 0.0057 16.9 0.0 0.38 10.9 0.0 2.3 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Fork_head PF00250.13 ESA05189.1 - 1.2e-36 124.6 0.7 1.6e-36 124.2 0.5 1.2 1 0 0 1 1 1 1 Fork head domain PMAIP1 PF15150.1 ESA05189.1 - 0.13 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Phorbol-12-myristate-13-acetate-induced Na_H_Exchanger PF00999.16 ESA05191.1 - 2.8e-08 32.6 3.1 3.3e-08 32.4 2.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Tetraspannin PF00335.15 ESA05191.1 - 2.9 7.1 6.2 12 5.1 4.3 2.0 1 1 0 1 1 1 0 Tetraspanin family Cg6151-P PF10233.4 ESA05192.1 - 7.7e-20 70.9 11.7 9.9e-20 70.6 8.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P EcsB PF05975.7 ESA05192.1 - 0.12 10.8 9.7 0.13 10.6 6.7 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB MpPF26 PF07666.6 ESA05192.1 - 0.16 11.8 9.4 0.25 11.2 6.5 1.4 1 0 0 1 1 1 0 M penetrans paralogue family 26 DUF95 PF01944.12 ESA05192.1 - 0.22 11.1 16.6 1 9.0 9.0 2.3 1 1 1 2 2 2 0 Integral membrane protein DUF95 PRA1 PF03208.14 ESA05192.1 - 0.9 8.8 12.4 2.1 7.6 3.5 2.0 1 1 1 2 2 2 0 PRA1 family protein DUF1430 PF07242.6 ESA05192.1 - 1.2 9.2 7.9 0.66 10.0 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) zf-DHHC PF01529.15 ESA05192.1 - 7.2 5.9 8.5 8.1 5.8 5.9 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Tic20 PF09685.5 ESA05192.1 - 9.2 6.2 16.8 4 7.4 5.5 2.2 2 0 0 2 2 2 0 Tic20-like protein DEAD PF00270.24 ESA05193.1 - 4.4e-39 133.6 0.6 7.4e-39 132.9 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA05193.1 - 9.9e-21 73.4 0.0 9.9e-11 41.3 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 ESA05193.1 - 0.018 14.8 2.5 0.069 12.9 0.0 2.8 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit HhH-GPD PF00730.20 ESA05194.1 - 2.8e-20 72.6 0.0 5.3e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 ESA05194.1 - 3.2e-07 29.6 0.5 1e-06 28.0 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 ESA05194.1 - 0.024 14.8 3.5 0.05 13.7 2.4 1.6 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Peptidase_M41 PF01434.13 ESA05195.1 - 5.7e-77 257.9 0.0 1e-76 257.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESA05195.1 - 6.4e-43 146.1 0.0 1.4e-42 145.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 ESA05195.1 - 3.6e-11 43.2 0.0 1e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.1 ESA05195.1 - 0.00096 19.9 0.0 0.0031 18.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA05195.1 - 0.00098 19.2 0.0 0.15 12.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 ESA05195.1 - 0.0016 17.2 0.1 0.0026 16.5 0.1 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 ESA05195.1 - 0.003 17.2 0.5 0.0099 15.6 0.3 1.9 1 0 0 1 1 1 1 Part of AAA domain RuvB_N PF05496.7 ESA05195.1 - 0.0051 15.8 0.0 0.0089 15.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 ESA05195.1 - 0.0087 15.7 0.4 0.053 13.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA05195.1 - 0.009 16.0 0.2 0.074 13.0 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.7 ESA05195.1 - 0.01 14.9 0.2 0.032 13.3 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.12 ESA05195.1 - 0.015 14.7 0.0 0.036 13.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 ESA05195.1 - 0.082 12.3 0.8 0.25 10.7 0.5 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA05195.1 - 0.089 12.6 0.1 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESA05195.1 - 0.12 12.7 0.0 0.46 10.7 0.0 2.0 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.16 ESA05195.1 - 0.14 11.2 0.3 0.36 9.9 0.2 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 ESA05195.1 - 0.21 11.5 0.5 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain RVT_1 PF00078.22 ESA05196.1 - 0.0004 19.8 0.2 0.00072 18.9 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF903 PF06004.7 ESA05198.1 - 0.2 11.2 2.2 0.31 10.5 1.5 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF903) Ubie_methyltran PF01209.13 ESA05199.1 - 3e-07 29.7 0.0 4.5e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 ESA05199.1 - 7.3e-07 29.0 0.0 1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA05199.1 - 8.8e-07 28.1 0.1 1e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.1 ESA05199.1 - 5.7e-06 25.9 0.0 8.8e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA05199.1 - 7e-06 26.4 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA05199.1 - 1.1e-05 25.9 0.0 2.3e-05 24.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA05199.1 - 0.0022 18.4 0.0 0.0047 17.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA05199.1 - 0.0033 17.7 0.0 0.0057 16.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA05199.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.7 ESA05199.1 - 0.041 13.2 0.1 0.11 11.9 0.0 1.7 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW DOT1 PF08123.8 ESA05199.1 - 0.061 12.6 0.0 0.16 11.2 0.0 1.7 2 0 0 2 2 2 0 Histone methylation protein DOT1 FtsJ PF01728.14 ESA05199.1 - 0.099 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 ESA05199.1 - 0.1 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.7 ESA05199.1 - 0.12 11.9 0.0 0.96 8.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF938) DUF3455 PF11937.3 ESA05202.1 - 1.2e-17 64.3 0.2 6.6e-17 62.0 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) JSRP PF15312.1 ESA05202.1 - 0.1 12.5 0.9 0.26 11.2 0.6 1.7 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Cyt-b5 PF00173.23 ESA05203.1 - 3.4e-25 87.6 0.0 4.8e-25 87.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_15 PF01793.11 ESA05204.1 - 3e-134 447.1 15.6 3.7e-134 446.8 10.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Cation_efflux PF01545.16 ESA05204.1 - 0.027 13.5 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 Cation efflux family Myosin_TH1 PF06017.8 ESA05205.1 - 0.021 14.1 1.0 0.026 13.8 0.7 1.1 1 0 0 1 1 1 0 Myosin tail AAA_13 PF13166.1 ESA05205.1 - 0.12 10.8 11.2 0.13 10.6 7.8 1.0 1 0 0 1 1 1 0 AAA domain HD_3 PF13023.1 ESA05205.1 - 0.22 11.2 2.7 0.28 10.8 1.9 1.1 1 0 0 1 1 1 0 HD domain DUF1168 PF06658.7 ESA05205.1 - 1.4 8.3 5.5 1.8 8.0 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) IncA PF04156.9 ESA05205.1 - 4.4 6.8 5.9 4.8 6.7 4.1 1.1 1 0 0 1 1 1 0 IncA protein Rhodanese PF00581.15 ESA05206.1 - 7.2e-08 32.7 0.0 1.4e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain ZZ PF00569.12 ESA05211.1 - 2.7e-15 55.6 29.7 3.5e-09 36.0 7.7 2.8 3 0 0 3 3 3 2 Zinc finger, ZZ type CCDC155 PF14662.1 ESA05211.1 - 0.016 14.8 5.2 0.022 14.3 3.6 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 DivIC PF04977.10 ESA05211.1 - 0.041 13.3 5.6 0.46 9.9 0.3 2.4 1 1 1 2 2 2 0 Septum formation initiator HALZ PF02183.13 ESA05211.1 - 0.057 13.1 1.5 0.057 13.1 1.0 2.3 2 2 0 2 2 2 0 Homeobox associated leucine zipper TLE_N PF03920.10 ESA05211.1 - 0.072 12.9 1.0 0.13 12.1 0.7 1.5 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain Tropomyosin_1 PF12718.2 ESA05211.1 - 0.22 11.3 5.5 0.37 10.6 3.8 1.4 1 0 0 1 1 1 0 Tropomyosin like ATG16 PF08614.6 ESA05211.1 - 0.27 11.0 5.2 0.42 10.4 3.6 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) SLAC1 PF03595.12 ESA05212.1 - 0.011 14.3 0.3 0.014 14.0 0.2 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel FUSC-like PF12805.2 ESA05213.1 - 0.077 11.9 0.1 0.08 11.8 0.1 1.0 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF842 PF05811.8 ESA05215.1 - 0.0079 15.6 0.1 0.01 15.2 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Baculo_PEP_C PF04513.7 ESA05215.1 - 0.05 13.4 0.0 0.062 13.1 0.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLYB PF05289.6 ESA05215.1 - 0.067 12.9 0.0 3 7.7 0.0 2.0 1 1 1 2 2 2 0 Borrelia hemolysin accessory protein STN1_2 PF09170.5 ESA05216.1 - 0.048 13.4 0.1 0.054 13.2 0.1 1.1 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 DUF1947 PF09183.5 ESA05216.1 - 2.7 7.8 5.2 0.69 9.7 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) DUF2969 PF11184.3 ESA05216.1 - 3.7 7.6 5.8 37 4.5 3.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2969) RrnaAD PF00398.15 ESA05217.1 - 1.1e-12 47.5 0.0 1.4e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Vmethyltransf PF01660.12 ESA05218.1 - 0.011 14.3 0.1 0.013 14.1 0.1 1.1 1 0 0 1 1 1 0 Viral methyltransferase LEA_4 PF02987.11 ESA05218.1 - 0.071 12.9 3.4 0.45 10.4 0.1 2.4 2 0 0 2 2 2 0 Late embryogenesis abundant protein LsmAD PF06741.8 ESA05218.1 - 0.13 12.3 4.4 5.5 7.1 0.1 2.4 2 1 0 2 2 2 0 LsmAD domain Pkinase PF00069.20 ESA05219.1 - 1.3e-05 24.4 0.4 0.0011 18.1 0.1 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05219.1 - 0.0047 16.0 0.2 0.09 11.8 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Lipase_3 PF01764.20 ESA05221.1 - 1.1e-26 93.0 0.0 2e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2305 PF10230.4 ESA05221.1 - 0.052 12.9 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 ESA05221.1 - 0.19 11.5 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Exo_endo_phos PF03372.18 ESA05222.1 - 4.8e-12 46.3 0.1 6.4e-12 45.9 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Mlp PF03304.8 ESA05222.1 - 1.8 8.5 5.5 1 9.3 0.7 2.5 3 0 0 3 3 3 0 Mlp lipoprotein family Pkinase PF00069.20 ESA05223.1 - 0.00011 21.4 0.0 0.00025 20.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05223.1 - 0.0013 17.8 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Transposase_mut PF00872.13 ESA05224.1 - 0.087 11.3 0.1 0.22 10.0 0.0 1.5 1 1 0 1 1 1 0 Transposase, Mutator family DUF1912 PF08930.5 ESA05226.1 - 0.053 13.6 1.0 0.083 12.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) Pkinase PF00069.20 ESA05227.1 - 1.1e-05 24.7 0.0 1.2e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05227.1 - 0.00019 20.6 0.0 0.00022 20.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2829 PF11195.3 ESA05227.1 - 0.1 13.0 0.4 0.21 12.1 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2829) UBN2_2 PF14227.1 ESA05227.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type cNMP_binding PF00027.24 ESA05230.1 - 2.3e-46 155.5 0.1 9e-24 83.1 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Borrelia_lipo_2 PF06238.6 ESA05231.1 - 0.027 14.5 0.6 0.033 14.2 0.4 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi BBR25 lipoprotein Retinal PF15449.1 ESA05233.1 - 0.17 9.5 3.2 0.19 9.3 2.2 1.0 1 0 0 1 1 1 0 Retinal protein CAP_N PF01213.14 ESA05236.1 - 2.1e-69 234.1 0.0 2.4e-69 234.0 0.0 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal NIF PF03031.13 ESA05236.1 - 0.026 14.2 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase BTG PF07742.7 ESA05237.1 - 0.11 12.0 0.4 0.19 11.2 0.2 1.4 1 0 0 1 1 1 0 BTG family LRR_7 PF13504.1 ESA05239.1 - 0.64 10.4 6.2 30 5.4 0.1 4.7 5 0 0 5 5 5 0 Leucine rich repeat Apc4 PF12896.2 ESA05240.1 - 0.0016 17.7 2.1 0.29 10.4 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 4 IncA PF04156.9 ESA05240.1 - 0.013 15.1 3.2 0.12 11.9 0.2 2.1 2 0 0 2 2 2 0 IncA protein CALCOCO1 PF07888.6 ESA05240.1 - 0.017 13.4 7.0 0.06 11.6 0.1 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Fib_alpha PF08702.5 ESA05240.1 - 0.033 14.3 17.2 0.24 11.5 4.0 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family SMAP PF15477.1 ESA05240.1 - 0.045 14.0 0.8 1.5 9.1 0.0 2.6 2 0 0 2 2 2 0 Small acidic protein family Laminin_I PF06008.9 ESA05240.1 - 0.065 12.5 12.5 0.4 9.9 1.4 2.2 2 0 0 2 2 2 0 Laminin Domain I Baculo_PEP_C PF04513.7 ESA05240.1 - 0.089 12.6 9.6 1.2 8.9 0.7 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 ESA05240.1 - 0.12 11.5 4.1 1.6 7.8 0.2 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF883 PF05957.8 ESA05240.1 - 0.23 11.8 5.7 3.5 8.0 0.1 3.0 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) SseC PF04888.7 ESA05240.1 - 0.27 10.5 5.9 0.54 9.5 0.0 2.5 3 0 0 3 3 3 0 Secretion system effector C (SseC) like family TBCA PF02970.11 ESA05240.1 - 0.35 10.9 7.6 3.1 7.9 0.3 3.0 3 0 0 3 3 3 0 Tubulin binding cofactor A BLOC1_2 PF10046.4 ESA05240.1 - 0.59 10.2 18.1 0.053 13.6 2.3 3.3 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.7 ESA05240.1 - 0.6 9.9 7.6 6 6.6 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF2265 PF10023.4 ESA05240.1 - 1 8.3 7.5 0.15 11.2 1.0 2.1 2 0 0 2 2 2 0 Predicted aminopeptidase (DUF2265) Spectrin PF00435.16 ESA05240.1 - 1.1 9.5 8.0 1.4 9.2 0.3 2.7 3 0 0 3 3 3 0 Spectrin repeat GCN5L1 PF06320.8 ESA05240.1 - 1.1 9.0 11.3 2.4 7.9 1.2 3.0 2 2 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) APG17 PF04108.7 ESA05240.1 - 1.8 7.3 18.1 0.24 10.1 2.2 2.5 2 1 0 2 2 2 0 Autophagy protein Apg17 CENP-Q PF13094.1 ESA05240.1 - 1.8 8.5 9.2 0.99 9.4 0.4 2.7 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit WXG100 PF06013.7 ESA05240.1 - 1.8 8.6 13.6 4.1 7.4 0.6 4.0 3 2 2 5 5 4 0 Proteins of 100 residues with WXG Laminin_II PF06009.7 ESA05240.1 - 2.3 7.9 13.0 1 9.0 0.8 3.1 2 2 1 3 3 3 0 Laminin Domain II V-SNARE PF05008.10 ESA05240.1 - 2.3 8.4 10.2 2.1 8.5 0.7 3.2 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus RasGAP PF00616.14 ESA05241.1 - 1.2e-53 181.7 4.0 1.6e-53 181.3 0.0 2.9 3 1 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 ESA05241.1 - 2.9e-34 117.7 1.6 9.7e-34 116.0 1.1 2.0 1 0 0 1 1 1 1 RasGAP C-terminus DUF972 PF06156.8 ESA05241.1 - 0.02 15.2 3.2 3.3 8.0 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF972) SSFA2_C PF14723.1 ESA05241.1 - 0.18 11.5 2.8 1 9.0 0.3 2.8 3 0 0 3 3 3 0 Sperm-specific antigen 2 C-terminus LigB PF02900.13 ESA05242.1 - 4.3e-52 176.7 0.0 4.9e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase SNF2_N PF00176.18 ESA05244.1 - 3e-37 128.0 0.0 4.3e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESA05244.1 - 6.1e-11 42.0 0.2 2.2e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA05244.1 - 5.6e-07 29.5 0.3 0.00016 21.5 0.0 3.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESA05244.1 - 0.00054 20.1 0.1 0.0091 16.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESA05244.1 - 0.0049 16.4 0.1 0.0081 15.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 ESA05244.1 - 0.015 14.2 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NOD PF06816.8 ESA05245.1 - 0.041 12.9 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 NOTCH protein UMPH-1 PF05822.7 ESA05246.1 - 4.1e-75 252.2 4.3 4.6e-75 252.1 3.0 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.2 ESA05246.1 - 0.00025 21.2 0.0 0.00039 20.6 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 ESA05246.1 - 0.0066 15.6 1.0 0.035 13.2 0.7 1.9 1 1 0 1 1 1 1 Putative Phosphatase NIF PF03031.13 ESA05246.1 - 0.037 13.6 0.0 0.63 9.6 0.0 2.4 2 1 0 2 2 2 0 NLI interacting factor-like phosphatase Imm24 PF15570.1 ESA05246.1 - 0.087 12.5 1.4 0.099 12.3 0.1 1.7 2 0 0 2 2 2 0 Immunity protein 24 PmrD PF11183.3 ESA05246.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Polymyxin resistance protein PmrD Myelin-PO_C PF10570.4 ESA05247.1 - 0.11 12.5 0.1 0.11 12.5 0.0 2.6 3 0 0 3 3 3 0 Myelin-PO cytoplasmic C-term p65 binding region UQ_con PF00179.21 ESA05248.1 - 2.5e-52 176.0 0.0 2.9e-52 175.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA05248.1 - 1.8e-07 30.9 0.0 2.2e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA05248.1 - 0.014 15.3 0.2 0.022 14.6 0.1 1.6 1 1 0 1 1 1 0 RWD domain Metal_CEHH PF14455.1 ESA05248.1 - 0.11 11.8 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Predicted metal binding domain DUF3116 PF11313.3 ESA05249.1 - 0.092 12.3 1.3 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3116) Piwi PF02171.12 ESA05250.1 - 2e-84 283.1 0.0 2.5e-84 282.8 0.0 1.0 1 0 0 1 1 1 1 Piwi domain XFP_C PF09363.5 ESA05251.1 - 0.073 12.4 0.2 0.076 12.4 0.1 1.1 1 0 0 1 1 1 0 XFP C-terminal domain Sel1 PF08238.7 ESA05252.1 - 2.8e-09 37.2 0.1 2.4e-08 34.3 0.1 2.1 2 1 0 2 2 2 1 Sel1 repeat Borrelia_orfA PF02414.10 ESA05252.1 - 0.039 13.0 0.6 0.037 13.1 0.4 1.1 1 0 0 1 1 1 0 Borrelia ORF-A TPR_6 PF13174.1 ESA05252.1 - 0.094 13.2 0.1 0.28 11.7 0.0 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA05253.1 - 1.7e-40 138.8 1.3 1.8e-40 138.7 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05253.1 - 1.7e-36 125.6 0.2 1.8e-36 125.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2004 PF09406.5 ESA05253.1 - 0.00088 19.3 0.2 0.0016 18.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2004) APH PF01636.18 ESA05253.1 - 0.032 13.9 0.1 0.05 13.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF928 PF06051.7 ESA05255.1 - 0.017 14.7 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) DUF1903 PF08991.5 ESA05256.1 - 0.1 12.7 0.2 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) DUF4206 PF13901.1 ESA05256.1 - 6.5 6.2 8.5 0.36 10.3 0.7 2.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4206) Pkinase_Tyr PF07714.12 ESA05257.1 - 4e-43 147.3 0.0 3.9e-40 137.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA05257.1 - 2.6e-38 131.6 1.1 9.6e-37 126.5 0.1 2.5 2 1 0 2 2 2 1 Protein kinase domain BCS1_N PF08740.6 ESA05257.1 - 2.6e-05 23.9 0.1 0.038 13.6 0.0 2.6 2 0 0 2 2 2 2 BCS1 N terminal APH PF01636.18 ESA05257.1 - 0.18 11.5 0.3 0.33 10.6 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family p450 PF00067.17 ESA05258.1 - 0.031 12.7 0.1 0.035 12.6 0.1 1.0 1 0 0 1 1 1 0 Cytochrome P450 DUF4254 PF14063.1 ESA05261.1 - 0.04 13.5 0.1 0.066 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4254) PAC2 PF09754.4 ESA05261.1 - 0.074 12.8 0.0 0.074 12.8 0.0 1.1 1 0 0 1 1 1 0 PAC2 family DUF972 PF06156.8 ESA05261.1 - 0.43 10.9 5.1 0.6 10.4 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) FlxA PF14282.1 ESA05261.1 - 1.6 8.7 5.6 3.3 7.7 3.9 1.6 1 1 0 1 1 1 0 FlxA-like protein ELO PF01151.13 ESA05263.1 - 3.8e-59 200.0 27.3 4.6e-59 199.7 18.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family TLD PF07534.11 ESA05264.1 - 1.6e-06 28.1 0.1 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 TLD K-box PF01486.12 ESA05264.1 - 0.045 13.5 0.0 0.071 12.9 0.0 1.3 1 0 0 1 1 1 0 K-box region Sigma_reg_N PF13800.1 ESA05265.1 - 0.091 12.7 7.2 0.56 10.2 0.0 3.1 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Glyco_transf_22 PF03901.12 ESA05267.1 - 4e-65 220.4 28.6 4.8e-65 220.1 19.8 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Cid2 PF09774.4 ESA05267.1 - 0.024 14.7 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Caffeine-induced death protein 2 F-box-like PF12937.2 ESA05269.1 - 0.00019 21.1 0.3 0.00046 19.8 0.2 1.7 1 0 0 1 1 1 1 F-box-like L-fibroin PF05849.6 ESA05270.1 - 0.039 13.2 0.0 0.048 12.9 0.0 1.1 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) NUC194 PF08163.7 ESA05270.1 - 0.062 12.1 0.3 0.067 12.0 0.2 1.0 1 0 0 1 1 1 0 NUC194 domain MCR_beta_N PF02783.10 ESA05270.1 - 0.064 12.7 0.0 0.069 12.5 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain 7tm_1 PF00001.16 ESA05271.1 - 0.0018 17.5 3.8 0.0024 17.0 2.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Str PF10326.4 ESA05271.1 - 0.084 11.9 7.9 0.13 11.3 5.5 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str TRP PF06011.7 ESA05271.1 - 0.3 9.6 6.7 0.32 9.5 4.4 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel VIT1 PF01988.14 ESA05271.1 - 0.51 9.7 4.0 0.25 10.7 1.5 1.4 1 1 0 1 1 1 0 VIT family DUF3112 PF11309.3 ESA05271.1 - 0.83 9.4 4.7 1.5 8.6 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) AA_permease_2 PF13520.1 ESA05272.1 - 2.8e-26 92.0 17.5 3.5e-26 91.7 12.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA05272.1 - 1.7e-17 62.9 14.9 2.2e-17 62.6 10.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.1 ESA05272.1 - 1.6e-09 37.4 0.9 1.6e-09 37.4 0.6 2.3 3 0 0 3 3 3 1 C-terminus of AA_permease DUF4131 PF13567.1 ESA05272.1 - 0.0081 15.5 3.5 0.024 14.0 0.0 2.6 1 1 1 3 3 3 1 Domain of unknown function (DUF4131) Chordopox_A13L PF05961.6 ESA05272.1 - 1 9.3 7.4 5.4 7.0 1.0 2.8 3 0 0 3 3 3 0 Chordopoxvirus A13L protein DZR PF12773.2 ESA05273.1 - 0.014 15.2 0.2 0.02 14.7 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon Cript PF10235.4 ESA05273.1 - 0.087 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT Zn-ribbon_8 PF09723.5 ESA05273.1 - 0.25 11.3 2.3 3.3 7.7 0.1 2.3 2 0 0 2 2 2 0 Zinc ribbon domain zf-AD PF07776.10 ESA05275.1 - 0.032 14.2 1.3 0.14 12.1 0.9 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) SAP PF02037.22 ESA05275.1 - 0.07 12.6 0.1 0.16 11.5 0.1 1.7 1 0 0 1 1 1 0 SAP domain Methyltransf_32 PF13679.1 ESA05275.1 - 0.085 12.5 0.1 0.25 11.0 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Transformer PF06495.6 ESA05277.1 - 0.59 9.9 14.9 0.042 13.7 1.7 2.2 2 0 0 2 2 2 0 Fruit fly transformer protein Secretin_N_2 PF07655.8 ESA05277.1 - 0.65 10.4 10.9 5.3 7.4 0.3 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain His_Phos_1 PF00300.17 ESA05278.1 - 1.2e-05 25.4 0.0 1.6e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PGAP1 PF07819.8 ESA05278.1 - 0.1 12.1 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein DUF4583 PF15190.1 ESA05279.1 - 0.14 11.8 2.2 0.18 11.4 1.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4583) TLD PF07534.11 ESA05280.1 - 2.6e-08 33.9 3.2 4.7e-08 33.1 2.2 1.5 1 0 0 1 1 1 1 TLD TNV_CP PF03898.8 ESA05280.1 - 0.1 11.6 0.3 0.2 10.6 0.0 1.5 2 0 0 2 2 2 0 Satellite tobacco necrosis virus coat protein SMN PF06003.7 ESA05281.1 - 5e-09 35.6 0.1 1.9e-08 33.7 0.0 1.6 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) TUDOR PF00567.19 ESA05281.1 - 0.00011 22.0 0.0 0.00022 21.0 0.0 1.4 1 1 0 1 1 1 1 Tudor domain LBR_tudor PF09465.5 ESA05281.1 - 0.00091 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Lamin-B receptor of TUDOR domain DUF4537 PF15057.1 ESA05281.1 - 0.0082 15.9 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.5 ESA05281.1 - 0.097 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor 7TMR-HDED PF07697.6 ESA05281.1 - 0.17 11.6 1.5 0.22 11.2 1.0 1.1 1 0 0 1 1 1 0 7TM-HD extracellular YwhD PF08741.5 ESA05282.1 - 0.012 15.0 1.8 0.016 14.6 1.3 1.2 1 0 0 1 1 1 0 YwhD family LON PF02190.11 ESA05282.1 - 1.5 8.4 7.0 4.8 6.8 4.9 1.8 1 1 0 1 1 1 0 ATP-dependent protease La (LON) domain Fib_alpha PF08702.5 ESA05282.1 - 3.8 7.6 8.2 1.5 8.9 3.2 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family RVT_1 PF00078.22 ESA05284.1 - 0.00073 18.9 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AAA_11 PF13086.1 ESA05285.1 - 3.3e-15 56.3 2.5 3.7e-15 56.1 0.2 2.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 ESA05285.1 - 1.5e-07 31.0 0.0 3.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA05285.1 - 2.6e-05 23.3 0.0 5.7e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) CobT PF06213.7 ESA05285.1 - 0.00065 18.9 4.0 0.00065 18.9 2.8 2.0 2 0 0 2 2 2 1 Cobalamin biosynthesis protein CobT AAA_30 PF13604.1 ESA05285.1 - 0.0013 18.3 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA05285.1 - 0.018 15.0 0.0 0.044 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ResIII PF04851.10 ESA05285.1 - 0.024 14.4 9.8 0.023 14.5 3.9 2.8 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit YL1 PF05764.8 ESA05285.1 - 0.03 13.9 15.0 0.07 12.7 10.4 1.5 1 0 0 1 1 1 0 YL1 nuclear protein AAA_22 PF13401.1 ESA05285.1 - 0.085 13.0 0.0 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESA05285.1 - 0.43 10.7 3.3 1.8 8.8 0.5 2.9 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) CDC45 PF02724.9 ESA05285.1 - 2.3 6.1 12.7 4.1 5.3 8.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Pkinase_Tyr PF07714.12 ESA05288.1 - 9.9e-31 106.7 0.0 1.2e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05288.1 - 2e-30 105.8 0.0 2.6e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Nucleoporin_N PF08801.6 ESA05290.1 - 1.8e-29 102.7 0.2 2.2e-29 102.4 0.2 1.1 1 0 0 1 1 1 1 Nup133 N terminal like IncA PF04156.9 ESA05292.1 - 0.0074 15.8 15.0 0.0074 15.8 10.4 2.6 1 1 1 2 2 2 2 IncA protein DUF4206 PF13901.1 ESA05292.1 - 0.19 11.2 6.5 0.098 12.1 1.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) LOH1CR12 PF10158.4 ESA05292.1 - 0.55 10.0 15.6 0.27 11.0 0.7 3.5 2 1 2 4 4 4 0 Tumour suppressor protein tRNA-synt_His PF13393.1 ESA05292.1 - 0.88 8.5 11.3 1.4 7.8 3.0 2.2 1 1 1 2 2 2 0 Histidyl-tRNA synthetase NPV_P10 PF05531.7 ESA05292.1 - 1.2 9.4 23.4 0.39 10.9 1.4 3.9 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Flagellin_N PF00669.15 ESA05292.1 - 1.2 8.8 8.0 0.75 9.5 0.1 2.7 2 1 1 3 3 3 0 Bacterial flagellin N-terminal helical region MutS_III PF05192.13 ESA05292.1 - 1.4 8.6 15.7 0.29 10.8 6.6 2.5 1 1 1 2 2 2 0 MutS domain III DUF4349 PF14257.1 ESA05292.1 - 1.8 7.7 14.8 0.043 13.0 0.7 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) DNA_repr_REX1B PF14966.1 ESA05292.1 - 1.8 8.9 11.8 2.6 8.5 0.4 3.4 2 1 2 4 4 4 0 DNA repair REX1-B Glutaredoxin2_C PF04399.8 ESA05292.1 - 3 7.4 14.7 7.6 6.1 0.3 3.4 1 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain CorA PF01544.13 ESA05292.1 - 3.3 6.6 17.9 0.058 12.4 4.9 2.7 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein DUF4208 PF13907.1 ESA05292.1 - 4.3 7.6 22.7 0.83 9.9 3.0 4.1 2 1 3 5 5 5 0 Domain of unknown function (DUF4208) Tweety PF04906.8 ESA05292.1 - 4.4 5.6 6.6 2.4 6.4 2.9 1.8 1 1 0 1 1 1 0 Tweety Spectrin PF00435.16 ESA05292.1 - 4.6 7.5 28.9 8.7 6.6 1.5 4.1 2 1 2 4 4 4 0 Spectrin repeat DUF4140 PF13600.1 ESA05292.1 - 5.4 7.5 12.2 1.8 9.0 1.3 3.5 1 1 3 4 4 4 0 N-terminal domain of unknown function (DUF4140) PH_3 PF14593.1 ESA05293.1 - 0.085 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 PH domain CH PF00307.26 ESA05293.1 - 0.11 12.4 0.2 0.33 11.0 0.1 1.9 2 1 0 2 2 2 0 Calponin homology (CH) domain Ribosomal_L33 PF00471.15 ESA05294.1 - 0.016 15.4 0.3 0.058 13.6 0.1 2.0 1 1 1 2 2 2 0 Ribosomal protein L33 FrhB_FdhB_C PF04432.8 ESA05295.1 - 0.0035 16.7 1.6 0.0052 16.2 1.1 1.3 1 0 0 1 1 1 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus SurA_N_2 PF13623.1 ESA05295.1 - 0.046 13.7 3.3 0.08 12.9 2.3 1.4 1 0 0 1 1 1 0 SurA N-terminal domain L71 PF02448.10 ESA05295.1 - 3 7.7 7.3 23 4.9 2.8 2.5 2 0 0 2 2 2 0 L71 family Helicase_C PF00271.26 ESA05296.1 - 4.9e-12 45.5 0.2 3.6e-11 42.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA05296.1 - 5.8e-05 22.6 0.7 0.1 12.0 0.0 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase SNF2_N PF00176.18 ESA05296.1 - 0.016 13.9 0.1 0.038 12.8 0.1 1.5 1 1 0 1 1 1 0 SNF2 family N-terminal domain ResIII PF04851.10 ESA05296.1 - 0.02 14.6 1.0 0.18 11.6 0.0 2.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 ESA05296.1 - 0.076 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Helicase C-terminal domain BTB_2 PF02214.17 ESA05298.1 - 1e-20 73.6 0.3 2.3e-20 72.5 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain HMG_box PF00505.14 ESA05299.1 - 6.5e-08 32.7 0.7 1.4e-07 31.7 0.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA05299.1 - 9.5e-06 25.8 0.2 2.2e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain Rsm22 PF09243.5 ESA05301.1 - 5.4e-68 228.9 0.0 2.5e-67 226.8 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_31 PF13847.1 ESA05301.1 - 1.1e-05 25.0 0.0 0.00017 21.1 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA05301.1 - 3.3e-05 24.2 0.3 0.00029 21.2 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA05301.1 - 9e-05 23.0 0.0 0.00017 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA05301.1 - 0.00012 22.3 0.0 0.00037 20.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA05301.1 - 0.0004 20.1 0.0 0.00094 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA05301.1 - 0.0028 18.1 0.0 0.017 15.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain ADK PF00406.17 ESA05302.1 - 5.6e-47 159.3 0.0 6.8e-47 159.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 ESA05302.1 - 1.7e-13 50.9 0.0 2.7e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA05302.1 - 6e-08 33.5 0.0 8.9e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESA05302.1 - 9.9e-08 31.9 0.0 4e-07 30.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 ESA05302.1 - 4.9e-07 29.2 0.2 0.0042 16.4 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase dNK PF01712.14 ESA05302.1 - 0.001 18.9 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Deoxynucleoside kinase Zeta_toxin PF06414.7 ESA05302.1 - 0.053 12.6 0.0 0.13 11.3 0.0 1.8 1 1 0 1 1 1 0 Zeta toxin QCR10 PF09796.4 ESA05303.1 - 1.4e-17 63.1 0.0 1.7e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.5 ESA05303.1 - 0.035 13.8 0.0 0.056 13.1 0.0 1.3 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein FAR1 PF03101.10 ESA05304.1 - 9.9e-07 29.2 2.8 9.9e-07 29.2 1.9 2.5 3 0 0 3 3 3 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA05304.1 - 0.51 9.9 7.1 28 4.3 4.9 2.6 1 1 0 1 1 1 0 MuDR family transposase Ribosomal_L17 PF01196.14 ESA05305.1 - 2.3e-32 111.4 1.7 3e-32 111.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L17 ATP_transf PF09830.4 ESA05306.1 - 1.8e-24 85.2 0.1 3.7e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 ESA05306.1 - 2.1e-05 24.9 0.1 8.8e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 HIT domain Transglut_core PF01841.14 ESA05307.1 - 4.3e-07 30.1 0.0 1.2e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Transglutaminase-like superfamily DUF553 PF04473.7 ESA05307.1 - 0.0018 17.6 0.6 0.2 10.9 0.4 2.6 1 1 0 1 1 1 1 Transglutaminase-like domain DUF4247 PF14042.1 ESA05307.1 - 0.37 10.7 3.3 0.81 9.6 1.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4247) DsrD PF08679.6 ESA05309.1 - 0.047 13.6 1.4 0.069 13.1 0.9 1.4 1 1 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) zf-CCHC PF00098.18 ESA05310.1 - 0.032 14.1 3.6 0.071 13.0 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF2746 PF10874.3 ESA05311.1 - 0.018 15.1 0.1 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) TAP42 PF04177.7 ESA05311.1 - 0.032 13.1 1.4 0.031 13.2 0.9 1.1 1 0 0 1 1 1 0 TAP42-like family Ribosomal_S2 PF00318.15 ESA05311.1 - 0.064 12.4 0.3 0.07 12.3 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 Fer4_4 PF12800.2 ESA05312.1 - 0.69 10.4 2.8 7.6 7.1 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain WWE PF02825.15 ESA05313.1 - 0.00034 19.9 0.2 0.67 9.4 0.0 2.9 1 1 1 2 2 2 2 WWE domain 7TM_GPCR_Srb PF02175.11 ESA05316.1 - 0.08 12.4 0.5 0.075 12.5 0.4 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srb LVIVD PF08309.6 ESA05316.1 - 0.86 8.6 2.8 1.4 7.9 1.9 1.3 1 0 0 1 1 1 0 LVIVD repeat DUF4422 PF14393.1 ESA05318.1 - 0.27 10.8 4.7 1.4 8.4 0.4 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4422) Z1 PF10593.4 ESA05318.1 - 1.1 8.4 5.8 1.7 7.8 0.1 2.5 3 0 0 3 3 3 0 Z1 domain Tox-REase-5 PF15648.1 ESA05319.1 - 0.12 12.6 1.4 0.25 11.6 1.0 1.7 1 1 0 1 1 1 0 Restriction endonuclease fold toxin 5 UPF0231 PF06062.6 ESA05319.1 - 0.37 10.6 4.1 0.46 10.3 2.3 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) DUF3519 PF12033.3 ESA05319.1 - 1.3 9.2 6.2 1.1 9.5 2.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3519) Dimer_Tnp_hAT PF05699.9 ESA05321.1 - 5.1e-12 45.2 0.7 1.2e-11 44.0 0.5 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Cortex-I_coil PF09304.5 ESA05322.1 - 0.023 14.7 2.2 0.037 14.0 1.5 1.3 1 0 0 1 1 1 0 Cortexillin I, coiled coil EKR PF10371.4 ESA05323.1 - 0.041 13.4 0.0 0.05 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function ubiquitin PF00240.18 ESA05325.1 - 1e-12 47.2 1.1 1.9e-12 46.3 0.2 1.7 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 ESA05325.1 - 1.6e-06 27.7 0.0 2.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Lipocalin_5 PF13924.1 ESA05325.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipocalin-like domain DUF3990 PF13151.1 ESA05325.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) HMG_box_2 PF09011.5 ESA05326.1 - 3.7e-07 30.3 0.5 7.1e-07 29.5 0.4 1.5 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA05326.1 - 2.7e-06 27.5 1.4 6.6e-06 26.3 1.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box DUF3284 PF11687.3 ESA05326.1 - 0.00068 19.3 1.1 0.0014 18.3 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3284) DUF2829 PF11195.3 ESA05326.1 - 0.2 12.1 1.8 0.54 10.7 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2829) DUF778 PF05608.7 ESA05326.1 - 0.23 11.3 3.9 1.1 9.1 2.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF778) DUF3883 PF13020.1 ESA05326.1 - 0.23 11.2 2.6 0.44 10.3 0.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3883) Pkinase_Tyr PF07714.12 ESA05327.1 - 0.048 12.7 0.0 0.088 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Dimer_Tnp_hAT PF05699.9 ESA05328.1 - 1.4e-05 24.5 1.9 2.1e-05 24.0 1.3 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region UNC45-central PF11701.3 ESA05328.1 - 0.068 12.8 0.2 0.13 11.8 0.1 1.5 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central DUF4216 PF13952.1 ESA05329.1 - 0.014 14.8 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) TPR_11 PF13414.1 ESA05330.1 - 0.00048 19.7 0.0 0.00054 19.5 0.0 1.1 1 0 0 1 1 1 1 TPR repeat TPR_8 PF13181.1 ESA05330.1 - 0.0009 18.8 0.2 0.93 9.4 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA05330.1 - 0.0053 16.8 0.0 0.0062 16.6 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA05330.1 - 0.0091 16.3 0.0 0.01 16.1 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA05330.1 - 0.015 15.2 0.1 52 3.8 0.0 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA05330.1 - 0.016 15.0 0.0 4.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA05330.1 - 0.045 13.6 0.2 0.068 13.0 0.1 1.4 1 1 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 ESA05330.1 - 0.047 13.3 0.1 5.6 6.7 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HAD_2 PF13419.1 ESA05331.1 - 3.4e-25 89.2 0.0 4.1e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA05331.1 - 6.8e-14 52.7 0.0 1.9e-12 48.0 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA05331.1 - 2.4e-07 30.3 0.0 4.9e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 ESA05331.1 - 0.0063 16.3 0.1 2.6 7.9 0.0 2.7 3 1 0 3 3 3 2 Haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA05331.1 - 0.012 15.7 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3684 PF12449.3 ESA05332.1 - 4.4e-72 243.1 0.0 2.6e-65 220.7 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) PYC_OADA PF02436.13 ESA05334.1 - 2.3e-67 226.2 0.0 4e-67 225.4 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain HMGL-like PF00682.14 ESA05334.1 - 1.2e-25 90.5 0.0 2.2e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.17 ESA05334.1 - 1e-17 63.5 3.1 8.1e-17 60.6 0.9 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 ESA05334.1 - 1.7e-12 46.8 0.5 6.3e-05 22.5 0.2 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD PF00529.15 ESA05334.1 - 6.6e-08 32.2 0.4 0.0067 15.7 0.0 2.6 2 1 1 3 3 3 2 HlyD family secretion protein HlyD_3 PF13437.1 ESA05334.1 - 0.00031 21.0 0.3 1 9.7 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein DUF2118 PF09891.4 ESA05334.1 - 0.051 13.2 0.3 0.18 11.5 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) Spermine_synth PF01564.12 ESA05335.1 - 7.4e-19 67.6 0.0 1.5e-18 66.6 0.0 1.5 2 0 0 2 2 2 1 Spermine/spermidine synthase DUF2346 PF09803.4 ESA05337.1 - 1.7e-07 30.9 0.9 2.2e-07 30.6 0.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2346) Cyclin PF08613.6 ESA05338.1 - 4.6e-20 72.5 1.9 4.6e-20 72.5 1.3 2.7 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 ESA05338.1 - 3.5e-09 36.2 4.8 8.2e-09 35.1 0.0 3.1 3 0 0 3 3 3 1 Cyclin, N-terminal domain FB_lectin PF07367.6 ESA05338.1 - 0.048 13.2 0.3 0.048 13.2 0.2 3.0 3 0 0 3 3 3 0 Fungal fruit body lectin TRI5 PF06330.6 ESA05343.1 - 0.00017 20.3 0.3 0.00028 19.6 0.2 1.4 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) BLOC1_2 PF10046.4 ESA05343.1 - 0.014 15.4 2.2 0.014 15.4 1.5 3.3 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ING PF12998.2 ESA05343.1 - 0.016 15.4 5.9 2.1 8.6 1.4 3.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Laminin_I PF06008.9 ESA05343.1 - 0.027 13.7 12.5 0.34 10.2 1.8 2.2 2 0 0 2 2 2 0 Laminin Domain I Erp_C PF06780.6 ESA05343.1 - 0.028 14.2 6.7 0.029 14.2 1.1 2.5 2 1 0 2 2 2 0 Erp protein C-terminus Apolipoprotein PF01442.13 ESA05343.1 - 0.039 13.4 1.1 0.36 10.2 0.1 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Spc7 PF08317.6 ESA05343.1 - 0.083 11.5 15.1 0.052 12.2 3.1 2.3 2 1 0 2 2 2 0 Spc7 kinetochore protein V-SNARE PF05008.10 ESA05343.1 - 0.094 12.8 7.3 0.18 11.9 0.3 3.0 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF484 PF04340.7 ESA05343.1 - 0.16 11.4 3.3 0.39 10.1 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF484 TMF_TATA_bd PF12325.3 ESA05343.1 - 0.17 11.6 4.3 8.4 6.1 0.3 3.2 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESA05343.1 - 0.24 10.9 1.8 5.3 6.5 0.0 2.1 2 0 0 2 2 2 0 IncA protein ArsR PF09824.4 ESA05343.1 - 0.27 10.5 4.5 0.09 12.0 0.4 2.1 2 1 0 2 2 2 0 ArsR transcriptional regulator Fib_alpha PF08702.5 ESA05343.1 - 0.31 11.1 17.2 2 8.5 2.5 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.6 ESA05343.1 - 0.33 11.3 11.3 5.9 7.3 1.5 3.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal FlgN PF05130.7 ESA05343.1 - 0.34 11.1 5.2 6.9 6.9 0.2 2.4 2 1 0 2 2 2 0 FlgN protein Z1 PF10593.4 ESA05343.1 - 0.42 9.7 8.7 3.3 6.8 2.4 2.2 2 0 0 2 2 2 0 Z1 domain Vps51 PF08700.6 ESA05343.1 - 0.89 9.4 7.1 1.9 8.3 0.3 3.2 3 2 1 4 4 3 0 Vps51/Vps67 RmuC PF02646.11 ESA05343.1 - 1.1 8.0 8.9 1.5 7.6 1.6 2.5 2 1 0 2 2 2 0 RmuC family DUF1759 PF03564.10 ESA05343.1 - 1.5 8.6 10.0 1.2 8.9 0.7 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF1759) DUF4200 PF13863.1 ESA05343.1 - 1.8 8.5 11.3 0.65 9.9 0.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Flagellin_N PF00669.15 ESA05343.1 - 2.1 8.1 11.4 0.54 10.0 0.6 3.0 3 0 0 3 3 3 0 Bacterial flagellin N-terminal helical region DUF755 PF05501.6 ESA05343.1 - 2.6 8.0 11.6 0.27 11.2 2.5 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF755) Streptin-Immun PF11083.3 ESA05343.1 - 2.8 8.0 9.1 2.3 8.2 0.4 3.4 2 1 0 3 3 3 0 Lantibiotic streptin immunity protein WXG100 PF06013.7 ESA05343.1 - 2.8 8.0 13.0 23 5.0 0.3 4.5 3 2 2 5 5 5 0 Proteins of 100 residues with WXG DUF3810 PF12725.2 ESA05343.1 - 5.4 5.8 7.2 7.5 5.3 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) GCN5L1 PF06320.8 ESA05343.1 - 6 6.7 9.9 8 6.3 1.0 2.9 2 2 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) OSCP PF00213.13 ESA05343.1 - 6 6.6 10.1 1.4 8.7 1.3 2.4 2 1 1 3 3 3 0 ATP synthase delta (OSCP) subunit HTH_38 PF13936.1 ESA05344.1 - 0.00014 21.2 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA05344.1 - 0.0011 18.5 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA05344.1 - 0.0039 17.3 0.0 0.0043 17.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix Imm25 PF15571.1 ESA05345.1 - 0.16 12.0 1.6 2.6 8.1 0.0 2.4 2 1 0 2 2 2 0 Immunity protein 25 YL1 PF05764.8 ESA05346.1 - 2.9e-05 23.8 19.0 4e-05 23.3 13.2 1.2 1 0 0 1 1 1 1 YL1 nuclear protein Borrelia_P83 PF05262.6 ESA05346.1 - 0.0075 14.5 12.7 0.0077 14.5 8.8 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein RR_TM4-6 PF06459.7 ESA05346.1 - 0.042 13.7 15.7 0.057 13.3 10.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.1 ESA05346.1 - 0.17 10.9 8.1 0.23 10.5 5.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain SRP-alpha_N PF04086.8 ESA05346.1 - 0.2 10.9 23.8 0.32 10.3 16.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PT PF04886.7 ESA05346.1 - 0.62 9.4 11.8 1.6e+02 1.6 8.2 2.5 1 1 0 1 1 1 0 PT repeat DUF936 PF06075.7 ESA05346.1 - 0.9 8.3 24.4 4.3 6.1 14.5 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) DUF1510 PF07423.6 ESA05346.1 - 1.2 8.4 24.3 3.8 6.8 16.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) DUF4106 PF13388.1 ESA05346.1 - 1.2 7.9 16.3 1.9 7.3 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Pkinase PF00069.20 ESA05347.1 - 3.2e-43 147.7 0.5 4e-43 147.4 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05347.1 - 5.2e-43 146.9 0.1 6.4e-43 146.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ESA05347.1 - 2.9e-05 23.5 0.1 4.6e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA05347.1 - 0.00036 19.5 0.0 0.0063 15.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like WaaY PF06176.6 ESA05347.1 - 0.0013 18.0 0.1 0.0025 17.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA05347.1 - 0.002 17.2 0.1 0.0032 16.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA05347.1 - 0.0028 17.4 0.1 0.0043 16.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA05347.1 - 0.0043 16.4 1.8 0.02 14.2 0.1 2.2 2 1 0 2 2 2 1 RIO1 family XPA_N PF01286.13 ESA05349.1 - 0.097 12.3 1.1 0.17 11.5 0.8 1.4 1 0 0 1 1 1 0 XPA protein N-terminal DUF1053 PF06327.9 ESA05349.1 - 5.5 7.3 8.3 2.6 8.4 2.1 2.8 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1053) NOGCT PF08155.6 ESA05352.1 - 4.8e-29 99.8 3.8 9.9e-29 98.8 0.7 2.5 2 0 0 2 2 2 1 NOGCT (NUC087) domain NOG1 PF06858.9 ESA05352.1 - 1.1e-27 95.6 0.3 2.8e-27 94.3 0.2 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 ESA05352.1 - 1.7e-17 63.4 0.1 1e-16 60.9 0.0 2.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA05352.1 - 4.1e-10 39.1 0.2 1.3e-09 37.5 0.0 2.0 2 1 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 ESA05352.1 - 0.00018 21.9 0.0 0.00093 19.6 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein Dynamin_N PF00350.18 ESA05352.1 - 0.0016 18.3 1.7 1.4 8.7 0.0 3.3 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.11 ESA05352.1 - 0.003 16.6 0.0 0.0093 15.0 0.0 1.9 1 0 0 1 1 1 1 AIG1 family DUF258 PF03193.11 ESA05352.1 - 0.012 14.8 0.0 0.11 11.7 0.0 2.3 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA05352.1 - 0.52 11.1 3.1 8.4 7.2 0.0 3.4 3 1 0 3 3 3 0 AAA domain Pam17 PF08566.5 ESA05353.1 - 2.3e-55 186.9 0.0 2.7e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Mga PF05043.8 ESA05355.1 - 0.0083 16.3 0.4 0.012 15.8 0.3 1.5 1 1 0 1 1 1 1 Mga helix-turn-helix domain CYTH PF01928.16 ESA05357.1 - 4.1e-12 46.1 0.4 6.5e-12 45.5 0.3 1.3 1 0 0 1 1 1 1 CYTH domain Radical_SAM PF04055.16 ESA05358.1 - 2.4e-18 66.8 0.2 3.7e-18 66.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 ESA05358.1 - 3.9e-08 33.5 0.9 8.9e-08 32.3 0.2 2.0 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 ESA05358.1 - 1.8e-06 27.9 0.7 3.4e-06 27.0 0.1 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Chordopox_A13L PF05961.6 ESA05358.1 - 0.0096 15.8 0.2 0.032 14.1 0.1 1.9 1 0 0 1 1 1 1 Chordopoxvirus A13L protein Tafi-CsgC PF10610.4 ESA05361.1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Thin aggregative fimbriae synthesis protein TRAPPC10 PF12584.3 ESA05361.1 - 0.086 12.3 0.3 0.1 12.1 0.2 1.3 1 1 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 CYTL1 PF15153.1 ESA05361.1 - 0.088 12.5 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Cytokine-like protein 1 SAP PF02037.22 ESA05362.1 - 0.046 13.2 0.1 0.087 12.3 0.1 1.5 1 0 0 1 1 1 0 SAP domain ThiF PF00899.16 ESA05364.1 - 3.5e-38 130.4 0.2 2.5e-37 127.7 0.1 2.0 2 0 0 2 2 2 1 ThiF family E2_bind PF08825.5 ESA05364.1 - 5.3e-26 90.1 1.9 9.4e-26 89.4 1.3 1.4 1 0 0 1 1 1 1 E2 binding domain UBACT PF02134.16 ESA05364.1 - 1.3e-24 85.4 2.2 2.9e-24 84.4 0.5 2.1 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 ESA05364.1 - 7.2e-18 63.6 2.9 1.7e-17 62.4 2.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site MoeZ_MoeB PF05237.8 ESA05364.1 - 9.9e-05 21.8 0.3 0.00049 19.6 0.0 2.1 2 0 0 2 2 2 1 MoeZ/MoeB domain Shikimate_DH PF01488.15 ESA05364.1 - 0.00076 19.5 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UBA_e1_C PF09358.5 ESA05364.1 - 0.0023 18.1 0.9 0.0051 16.9 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UAE_UbL PF14732.1 ESA05364.1 - 0.0083 16.1 0.3 0.018 15.1 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Ecm33 PF12454.3 ESA05364.1 - 0.069 13.0 2.9 0.14 12.0 2.0 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein HypA PF01155.14 ESA05364.1 - 0.14 11.8 0.4 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family F-box-like PF12937.2 ESA05366.1 - 3.6e-07 29.7 0.1 9.1e-07 28.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA05366.1 - 0.005 16.4 0.1 0.018 14.6 0.1 2.0 1 0 0 1 1 1 1 F-box domain Ribosomal_L22e PF01776.12 ESA05366.1 - 0.012 15.5 2.2 0.3 11.1 0.2 2.7 2 0 0 2 2 2 0 Ribosomal L22e protein family Ras PF00071.17 ESA05367.1 - 6.1e-14 51.7 0.0 1.3e-10 40.9 0.0 2.1 1 1 1 2 2 2 2 Ras family Miro PF08477.8 ESA05367.1 - 2.4e-06 28.0 0.0 0.024 15.1 0.0 2.3 1 1 1 2 2 2 2 Miro-like protein MobB PF03205.9 ESA05367.1 - 0.0098 15.5 0.0 0.023 14.4 0.0 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NAF PF03822.9 ESA05367.1 - 0.075 12.7 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 NAF domain PduV-EutP PF10662.4 ESA05367.1 - 0.091 12.2 0.0 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 ESA05367.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 ESA05367.1 - 0.12 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain IZUMO PF15005.1 ESA05369.1 - 0.15 12.0 5.7 0.29 11.1 4.0 1.4 1 0 0 1 1 1 0 Izumo sperm-egg fusion mRNA_cap_C PF03919.10 ESA05370.1 - 2.5e-17 63.1 1.1 3.5e-17 62.6 0.7 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain mRNA_cap_enzyme PF01331.14 ESA05370.1 - 1.6e-07 31.1 0.1 3.2e-07 30.2 0.0 1.5 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain RPA_interact_N PF14766.1 ESA05371.1 - 0.018 14.4 7.6 0.037 13.4 5.3 1.6 1 0 0 1 1 1 0 Replication protein A interacting N-terminal DUF4343 PF14243.1 ESA05371.1 - 0.091 12.6 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4343) LcrG PF07216.7 ESA05371.1 - 0.69 9.9 3.8 0.7 9.9 0.2 2.4 1 1 1 2 2 2 0 LcrG protein RhoGEF PF00621.15 ESA05373.1 - 1.3e-06 28.4 0.0 1.4e-06 28.3 0.0 1.0 1 0 0 1 1 1 1 RhoGEF domain DUF4477 PF14780.1 ESA05374.1 - 0.049 13.0 0.4 0.086 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) DUF3741 PF12552.3 ESA05374.1 - 0.069 12.8 0.7 10 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) Phage_hub_GP28 PF11110.3 ESA05374.1 - 0.07 12.8 0.3 5.9 6.5 0.0 2.1 2 0 0 2 2 2 0 Baseplate hub distal subunit iPGM_N PF06415.8 ESA05376.1 - 0.12 11.6 1.4 0.14 11.5 1.0 1.1 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) Cas_NE0113 PF09623.5 ESA05376.1 - 0.14 11.6 0.1 0.21 10.9 0.1 1.3 1 1 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) HIGH_NTase1 PF05636.6 ESA05379.1 - 0.064 12.2 2.8 0.077 12.0 1.9 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase HTH_12 PF08461.5 ESA05379.1 - 0.36 10.5 4.5 29 4.4 0.1 4.6 4 1 1 5 5 5 0 Ribonuclease R winged-helix domain PA_decarbox PF05870.6 ESA05379.1 - 0.93 8.9 3.6 16 4.9 0.1 2.7 2 1 1 3 3 3 0 Phenolic acid decarboxylase (PAD) Laminin_G_3 PF13385.1 ESA05381.1 - 0.00036 20.8 0.1 0.0004 20.6 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA05382.1 - 0.0031 17.0 0.1 0.017 14.6 0.1 2.0 1 1 0 1 1 1 1 MIR domain DUF2373 PF10180.4 ESA05383.1 - 0.034 13.6 5.5 0.077 12.5 0.5 2.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) BACK PF07707.10 ESA05384.1 - 0.0005 19.8 0.1 0.0018 18.0 0.1 2.1 1 1 0 1 1 1 1 BTB And C-terminal Kelch SRC-1 PF08832.5 ESA05385.1 - 4.8 7.9 7.6 0.48 11.2 2.0 1.7 2 0 0 2 2 2 0 Steroid receptor coactivator NUFIP1 PF10453.4 ESA05386.1 - 2.6e-15 55.6 2.7 6.2e-15 54.4 1.8 1.7 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) LRV_FeS PF05484.6 ESA05386.1 - 0.055 13.0 1.7 0.089 12.3 0.3 2.0 2 0 0 2 2 2 0 LRV protein FeS4 cluster DUF1981 PF09324.5 ESA05386.1 - 0.19 11.2 0.8 1.8 8.1 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) MIF4G PF02854.14 ESA05388.1 - 2.8e-41 141.2 4.8 3.6e-41 140.8 3.3 1.1 1 0 0 1 1 1 1 MIF4G domain DUF4041 PF13250.1 ESA05388.1 - 0.075 12.5 0.1 0.21 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) Aldo_ket_red PF00248.16 ESA05389.1 - 9.8e-06 24.5 0.0 1.1e-05 24.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3791 PF12668.2 ESA05392.1 - 0.0045 16.5 2.5 0.063 12.8 0.6 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3791) DUF1894 PF08979.6 ESA05392.1 - 0.1 12.6 1.1 1.4 9.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1894) Elongin_A PF06881.6 ESA05392.1 - 0.1 12.9 2.5 0.097 13.0 0.7 1.6 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A GHL15 PF14885.1 ESA05394.1 - 0.16 12.1 13.0 0.83 9.9 0.2 3.3 3 0 0 3 3 3 0 Hypothetical glycosyl hydrolase family 15 DUF2373 PF10180.4 ESA05394.1 - 1.7 8.2 10.6 1.2 8.7 0.2 3.6 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2373) SOCS PF12610.3 ESA05398.1 - 0.026 14.8 2.2 0.036 14.3 1.5 1.2 1 0 0 1 1 1 0 Suppressor of cytokine signalling Arrestin_N PF00339.24 ESA05399.1 - 2.1e-15 56.8 0.8 7.6e-15 55.0 0.1 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA05399.1 - 2.2e-15 56.9 1.7 2e-11 44.1 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 ESA05399.1 - 2.2e-05 24.0 0.1 2.2e-05 24.0 0.1 2.2 2 1 0 3 3 3 1 Arrestin_N terminal like LRR_6 PF13516.1 ESA05401.1 - 0.071 13.2 7.3 0.56 10.4 0.1 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Pkinase_Tyr PF07714.12 ESA05402.1 - 1.6e-30 106.0 0.3 8.2e-29 100.4 0.1 3.1 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05402.1 - 2.7e-26 92.2 2.4 2.7e-26 92.2 1.6 2.7 3 0 0 3 3 3 1 Protein kinase domain FAM72 PF14976.1 ESA05402.1 - 0.00013 21.8 8.0 0.59 9.9 0.1 3.3 3 0 0 3 3 3 3 FAM72 protein DUF2296 PF10058.4 ESA05402.1 - 0.0002 21.0 6.2 0.8 9.5 0.1 3.5 3 0 0 3 3 3 3 Predicted integral membrane metal-binding protein (DUF2296) UPF0149 PF03695.8 ESA05402.1 - 0.018 14.8 0.0 7.2 6.4 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0149) Fer4_9 PF13187.1 ESA05402.1 - 0.065 13.5 3.8 36 4.7 0.0 3.5 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.1 ESA05402.1 - 0.098 13.4 4.7 43 4.9 0.1 3.8 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain PNPase PF03726.9 ESA05404.1 - 0.099 12.9 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Claudin_2 PF13903.1 ESA05406.1 - 0.0033 17.1 0.4 0.004 16.8 0.3 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction ABC2_membrane_5 PF13346.1 ESA05406.1 - 0.039 13.2 3.7 0.29 10.3 0.1 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF4282 PF14110.1 ESA05406.1 - 0.19 11.9 4.0 0.29 11.3 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) DUF202 PF02656.10 ESA05406.1 - 0.31 11.3 8.1 4.4 7.5 5.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Peptidase_M50B PF13398.1 ESA05406.1 - 0.39 10.0 4.9 0.44 9.9 1.9 1.8 1 1 1 2 2 2 0 Peptidase M50B-like DUF3397 PF11877.3 ESA05406.1 - 0.56 10.2 5.2 2.1 8.3 3.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3397) DUF217 PF02697.9 ESA05409.1 - 0.27 11.4 4.1 1.3 9.3 0.9 2.5 2 0 0 2 2 2 0 Uncharacterized ACR, COG1753 DUF4116 PF13475.1 ESA05414.1 - 0.028 13.8 2.3 1.5 8.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) Plasmod_Pvs28 PF06247.6 ESA05414.1 - 0.47 10.0 6.1 2.1 7.8 0.9 2.4 2 1 0 2 2 2 0 Plasmodium ookinete surface protein Pvs28 Ins_beta PF03488.9 ESA05414.1 - 1.2 9.0 3.7 8.4 6.2 0.1 2.7 3 0 0 3 3 3 0 Nematode insulin-related peptide beta type DUF1600 PF07667.6 ESA05415.1 - 0.036 14.1 1.3 0.038 14.0 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) RNaseH_C PF09293.5 ESA05416.1 - 0.037 13.9 0.7 0.065 13.1 0.3 1.5 1 1 0 1 1 1 0 T4 RNase H, C terminal HGD-D PF06050.8 ESA05416.1 - 0.06 12.1 0.1 0.076 11.8 0.1 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Methyltrn_RNA_4 PF09936.4 ESA05416.1 - 0.077 12.4 0.5 0.14 11.6 0.2 1.5 1 1 1 2 2 2 0 SAM-dependent RNA methyltransferase JmjC PF02373.17 ESA05418.1 - 7.8e-13 48.6 0.0 2.5e-12 47.0 0.0 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 ESA05418.1 - 8.7e-06 25.4 0.1 0.0011 18.5 0.1 2.3 1 1 0 1 1 1 1 Cupin-like domain Ole-e-6 PF09253.5 ESA05418.1 - 0.056 13.1 0.2 0.17 11.5 0.1 1.7 1 0 0 1 1 1 0 Pollen allergen ole e 6 DUF4459 PF14673.1 ESA05418.1 - 0.056 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) Cupin_2 PF07883.6 ESA05418.1 - 0.069 12.6 0.1 0.18 11.2 0.1 1.7 1 1 0 1 1 1 0 Cupin domain Cupin_4 PF08007.7 ESA05418.1 - 0.095 11.9 0.0 0.26 10.4 0.0 1.7 2 0 0 2 2 2 0 Cupin superfamily protein HAD_2 PF13419.1 ESA05419.1 - 1.7e-23 83.7 0.0 2.4e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA05419.1 - 0.0039 17.6 0.1 0.0076 16.6 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2608 PF11019.3 ESA05419.1 - 0.014 14.4 4.7 0.72 8.7 0.2 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF2608) HAD PF12710.2 ESA05419.1 - 0.03 14.5 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ribosomal_S21 PF01165.15 ESA05420.1 - 3.6e-11 42.3 2.4 5.7e-11 41.7 1.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 SRP19 PF01922.12 ESA05420.1 - 0.048 14.2 0.5 0.048 14.2 0.4 1.1 1 0 0 1 1 1 0 SRP19 protein Clat_adaptor_s PF01217.15 ESA05421.1 - 5.8e-25 87.6 0.5 7.4e-25 87.3 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1219 PF06755.7 ESA05421.1 - 0.063 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1219) Steroid_dh PF02544.11 ESA05422.1 - 4.4e-38 130.4 5.9 9.1e-38 129.3 4.1 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.18 ESA05422.1 - 1.5e-07 30.6 0.3 2.7e-07 29.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA05422.1 - 0.00029 20.4 0.2 0.00045 19.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA05422.1 - 0.16 12.2 0.1 1.9 8.7 0.1 2.2 1 1 0 1 1 1 0 Ubiquitin-like domain Brix PF04427.13 ESA05423.1 - 4.6e-42 143.8 2.0 8.2e-42 143.0 1.4 1.4 1 0 0 1 1 1 1 Brix domain DUF3140 PF11338.3 ESA05423.1 - 0.026 14.6 0.9 0.065 13.3 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3140) SlyX PF04102.7 ESA05424.1 - 0.014 15.7 0.4 0.014 15.7 0.2 3.1 2 1 1 3 3 3 0 SlyX VIT1 PF01988.14 ESA05424.1 - 0.24 10.8 0.1 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 VIT family DUF1117 PF06547.7 ESA05424.1 - 0.59 10.2 9.7 0.76 9.8 1.1 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1117) Vac_Fusion PF02346.11 ESA05424.1 - 1.2 8.6 6.9 14 5.1 1.3 3.0 2 0 0 2 2 2 0 Chordopoxvirus fusion protein DUF1664 PF07889.7 ESA05424.1 - 3.5 7.4 10.2 15 5.4 4.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Synaptobrevin PF00957.16 ESA05424.1 - 6.3 6.4 17.6 0.1 12.1 3.8 3.0 2 1 1 3 3 3 0 Synaptobrevin Fzo_mitofusin PF04799.8 ESA05424.1 - 8.2 5.7 11.0 2.1 7.7 0.4 2.7 1 1 1 2 2 2 0 fzo-like conserved region SLBP_RNA_bind PF15247.1 ESA05427.1 - 0.14 11.9 3.0 0.4 10.4 2.1 1.8 1 0 0 1 1 1 0 Histone RNA hairpin-binding protein RNA-binding domain RPA_C PF08784.6 ESA05428.1 - 2.3e-08 34.3 0.9 4.5e-08 33.4 0.6 1.5 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 ESA05428.1 - 0.00046 19.9 0.2 0.00086 19.1 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain NAD_binding_6 PF08030.7 ESA05428.1 - 0.027 14.3 0.3 0.043 13.7 0.2 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain PRP3 PF08572.5 ESA05428.1 - 0.056 12.8 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Sec2p PF06428.6 ESA05429.1 - 9.9e-06 25.3 2.2 1.2e-05 25.1 1.6 1.1 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p WEMBL PF05701.6 ESA05429.1 - 0.00085 17.9 1.2 0.00089 17.8 0.8 1.0 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF1664 PF07889.7 ESA05429.1 - 0.00096 18.9 1.1 0.0012 18.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Filament PF00038.16 ESA05429.1 - 0.0012 18.3 0.7 0.0014 18.1 0.5 1.0 1 0 0 1 1 1 1 Intermediate filament protein Apolipoprotein PF01442.13 ESA05429.1 - 0.0016 17.9 0.5 0.0019 17.7 0.3 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain MscS_porin PF12795.2 ESA05429.1 - 0.0017 17.7 5.0 0.0023 17.3 3.4 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain AAA_13 PF13166.1 ESA05429.1 - 0.0018 16.8 1.4 0.002 16.6 1.0 1.0 1 0 0 1 1 1 1 AAA domain COG2 PF06148.6 ESA05429.1 - 0.0069 16.2 2.9 0.009 15.8 2.0 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 FliJ PF02050.11 ESA05429.1 - 0.0095 15.9 0.7 0.012 15.6 0.5 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein DUF3847 PF12958.2 ESA05429.1 - 0.0099 15.6 2.0 0.18 11.5 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3847) Sec20 PF03908.8 ESA05429.1 - 0.011 15.3 2.8 0.016 14.9 1.9 1.3 1 0 0 1 1 1 0 Sec20 BLOC1_2 PF10046.4 ESA05429.1 - 0.012 15.7 1.8 0.012 15.7 1.2 1.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.1 ESA05429.1 - 0.013 14.8 1.7 0.015 14.6 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Syntaxin_2 PF14523.1 ESA05429.1 - 0.017 15.1 7.3 0.052 13.5 5.0 1.8 1 1 0 1 1 1 0 Syntaxin-like protein Laminin_II PF06009.7 ESA05429.1 - 0.018 14.8 3.6 0.019 14.7 1.1 1.7 1 1 1 2 2 2 0 Laminin Domain II DUF342 PF03961.8 ESA05429.1 - 0.02 13.3 2.5 0.022 13.1 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spore_III_AB PF09548.5 ESA05429.1 - 0.029 14.1 0.7 0.034 13.8 0.5 1.0 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Latarcin PF10279.4 ESA05429.1 - 0.038 14.1 0.5 0.051 13.7 0.3 1.1 1 0 0 1 1 1 0 Latarcin precursor Poty_PP PF08440.5 ESA05429.1 - 0.039 13.0 2.2 0.043 12.8 1.5 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein Spc7 PF08317.6 ESA05429.1 - 0.044 12.4 3.3 0.049 12.2 2.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TBPIP PF07106.8 ESA05429.1 - 0.058 12.9 6.0 0.092 12.2 4.1 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fzo_mitofusin PF04799.8 ESA05429.1 - 0.061 12.7 2.4 0.075 12.4 1.7 1.1 1 0 0 1 1 1 0 fzo-like conserved region Muted PF14942.1 ESA05429.1 - 0.062 13.1 2.3 0.13 12.1 1.7 1.4 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein TMPIT PF07851.8 ESA05429.1 - 0.067 12.2 1.5 0.075 12.0 1.1 1.0 1 0 0 1 1 1 0 TMPIT-like protein Reo_sigmaC PF04582.7 ESA05429.1 - 0.069 12.3 1.7 0.074 12.2 1.2 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4446 PF14584.1 ESA05429.1 - 0.076 12.8 0.8 0.095 12.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Corona_S2 PF01601.11 ESA05429.1 - 0.081 11.0 0.7 0.085 10.9 0.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Prominin PF05478.6 ESA05429.1 - 0.12 9.9 2.3 0.13 9.8 1.6 1.1 1 0 0 1 1 1 0 Prominin ATG16 PF08614.6 ESA05429.1 - 0.12 12.2 4.5 0.15 11.8 3.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Filo_VP35 PF02097.10 ESA05429.1 - 0.12 11.5 0.7 0.13 11.4 0.5 1.1 1 0 0 1 1 1 0 Filoviridae VP35 IncA PF04156.9 ESA05429.1 - 0.15 11.6 3.5 0.17 11.4 2.4 1.2 1 0 0 1 1 1 0 IncA protein TPR_MLP1_2 PF07926.7 ESA05429.1 - 0.16 11.7 3.5 0.31 10.8 2.4 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF1098 PF06497.6 ESA05429.1 - 0.16 12.0 3.3 0.21 11.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1098) Glutaredoxin2_C PF04399.8 ESA05429.1 - 0.17 11.4 1.1 0.37 10.3 0.3 1.7 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain DUF948 PF06103.6 ESA05429.1 - 0.24 11.2 2.1 0.42 10.5 0.8 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2730 PF10805.3 ESA05429.1 - 0.28 10.9 1.9 0.48 10.1 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.7 ESA05429.1 - 0.32 10.8 4.6 0.53 10.1 2.0 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sec8_exocyst PF04048.9 ESA05429.1 - 0.36 10.4 5.2 2.7 7.6 3.9 1.8 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain YgaB PF14182.1 ESA05429.1 - 0.36 11.0 3.5 0.82 9.9 1.7 1.9 1 1 1 2 2 2 0 YgaB-like protein Snapin_Pallidin PF14712.1 ESA05429.1 - 0.49 10.7 5.6 1.1 9.5 3.9 1.6 1 1 0 1 1 1 0 Snapin/Pallidin DegQ PF08181.6 ESA05429.1 - 0.55 9.9 6.1 0.77 9.5 1.1 2.9 1 1 0 2 2 2 0 DegQ (SacQ) family DUF972 PF06156.8 ESA05429.1 - 0.55 10.5 3.0 0.43 10.9 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Prefoldin PF02996.12 ESA05429.1 - 0.79 9.3 4.0 0.77 9.4 0.6 2.1 1 1 1 2 2 2 0 Prefoldin subunit HR1 PF02185.11 ESA05429.1 - 1 9.1 5.7 3 7.6 0.8 2.2 2 0 0 2 2 2 0 Hr1 repeat Syntaxin-6_N PF09177.6 ESA05429.1 - 1 9.7 4.2 2 8.8 2.9 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal NPV_P10 PF05531.7 ESA05429.1 - 1.2 9.4 4.9 15 5.9 3.4 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 ESA05429.1 - 2 8.3 5.3 0.6 10.0 1.1 2.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Sec1 PF00995.18 ESA05430.1 - 1.4e-151 505.9 3.9 1.6e-151 505.7 2.7 1.0 1 0 0 1 1 1 1 Sec1 family Img2 PF05046.9 ESA05431.1 - 7.5e-23 80.5 0.3 1.4e-22 79.6 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial large subunit ribosomal protein (Img2) WD40 PF00400.27 ESA05432.1 - 0.0019 17.9 0.0 0.88 9.5 0.0 3.8 4 0 0 4 4 4 1 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESA05432.1 - 0.0034 17.1 2.0 1.1 9.0 0.0 3.4 4 1 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.1 ESA05432.1 - 0.042 13.3 0.0 8.4 5.7 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain DUF2419 PF10343.4 ESA05433.1 - 1.1e-25 90.4 0.1 1.4e-25 90.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2419) DnaJ PF00226.26 ESA05434.1 - 7.3e-20 70.4 0.1 1.3e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Cupin_8 PF13621.1 ESA05435.1 - 9e-18 64.6 0.5 1.5e-17 63.9 0.3 1.3 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 ESA05435.1 - 3.6e-15 56.2 0.1 3.9e-14 52.8 0.0 2.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.2 ESA05435.1 - 4.6e-06 26.2 0.6 4.6e-06 26.2 0.4 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA05435.1 - 0.00011 21.7 0.6 0.00038 20.0 0.4 2.0 1 0 0 1 1 1 1 F-box domain zf-CCCH PF00642.19 ESA05436.1 - 4.4e-08 32.6 34.8 6.5e-05 22.5 2.3 4.8 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) LRV_FeS PF05484.6 ESA05436.1 - 2.2 7.8 7.2 11 5.6 0.0 3.4 2 1 1 3 3 3 0 LRV protein FeS4 cluster DUF2156 PF09924.4 ESA05437.1 - 0.019 13.7 0.0 0.029 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2156) DUF2087 PF09860.4 ESA05437.1 - 0.028 14.1 0.4 0.2 11.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) PPR_2 PF13041.1 ESA05440.1 - 9.8e-22 76.6 4.5 2.3e-12 46.6 0.4 2.0 1 1 1 2 2 2 2 PPR repeat family PPR PF01535.15 ESA05440.1 - 3.8e-10 39.0 0.2 0.00024 20.8 0.1 2.1 2 0 0 2 2 2 2 PPR repeat PPR_1 PF12854.2 ESA05440.1 - 3e-08 32.9 8.0 0.00049 19.5 0.3 3.2 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.1 ESA05440.1 - 1e-07 31.6 0.0 0.027 14.7 0.0 2.5 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR_2 PF13041.1 ESA05441.1 - 5e-27 93.6 5.0 2.2e-14 53.1 0.1 4.4 1 1 3 5 5 5 5 PPR repeat family PPR PF01535.15 ESA05441.1 - 7.6e-24 81.9 3.5 1.7e-08 33.8 0.0 5.0 4 1 0 4 4 4 4 PPR repeat PPR_1 PF12854.2 ESA05441.1 - 3.6e-20 71.1 0.8 9.2e-07 28.2 0.0 5.1 4 1 0 4 4 4 4 PPR repeat PPR_3 PF13812.1 ESA05441.1 - 7.1e-19 66.4 0.0 3.5e-05 23.7 0.0 4.3 4 0 0 4 4 4 4 Pentatricopeptide repeat domain SPOB_a PF14689.1 ESA05441.1 - 0.0068 15.9 1.4 1.3 8.6 0.0 3.5 4 0 0 4 4 4 1 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_14 PF13428.1 ESA05441.1 - 0.013 16.1 0.0 5 8.0 0.0 3.3 1 1 3 4 4 4 0 Tetratricopeptide repeat YozD PF14162.1 ESA05441.1 - 0.072 13.1 0.1 9.7 6.3 0.0 2.9 2 1 1 3 3 3 0 YozD-like protein TPR_1 PF00515.23 ESA05441.1 - 0.077 12.6 4.8 0.35 10.5 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA05441.1 - 0.094 12.6 1.0 0.57 10.2 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA05441.1 - 0.1 12.5 0.9 1.3 9.0 0.4 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA05441.1 - 0.21 11.2 1.1 1 9.0 0.1 2.3 1 1 2 3 3 3 0 TPR repeat TPR_8 PF13181.1 ESA05441.1 - 0.99 9.3 5.7 1.1 9.2 0.7 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Rad51 PF08423.6 ESA05444.1 - 0.11 11.4 0.1 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad51 FtsK_SpoIIIE_N PF12538.3 ESA05445.1 - 0.13 12.3 1.0 0.46 10.6 0.0 2.4 3 0 0 3 3 3 0 DNA transporter Aminotran_3 PF00202.16 ESA05446.1 - 5.4e-05 22.2 0.0 6.2e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III COBRA1 PF06209.8 ESA05447.1 - 0.00011 21.0 0.1 0.00021 20.0 0.0 1.4 2 0 0 2 2 2 1 Cofactor of BRCA1 (COBRA1) Peptidase_M73 PF12389.3 ESA05448.1 - 0.13 11.7 1.3 0.15 11.5 0.9 1.2 1 0 0 1 1 1 0 Camelysin metallo-endopeptidase NAF PF03822.9 ESA05449.1 - 1.9 8.2 4.8 2.2 8.0 0.4 2.4 2 1 1 3 3 3 0 NAF domain Frizzled PF01534.12 ESA05450.1 - 0.034 12.9 0.5 0.052 12.3 0.4 1.2 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region LON PF02190.11 ESA05451.1 - 2.4e-26 92.6 0.0 4.2e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain zf-C3HC4_2 PF13923.1 ESA05451.1 - 1.2e-15 57.2 28.1 9.2e-12 44.7 8.2 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA05451.1 - 2.1e-12 46.7 24.2 1.6e-06 27.8 6.4 3.2 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 ESA05451.1 - 6.9e-12 44.8 19.6 1.8e-10 40.3 4.7 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA05451.1 - 8.2e-12 44.5 24.9 6.2e-09 35.3 7.8 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA05451.1 - 3.3e-10 39.6 24.1 4.6e-09 35.9 7.0 2.8 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.1 ESA05451.1 - 7.7e-10 38.3 27.8 5e-08 32.5 6.5 2.9 3 0 0 3 3 3 2 zinc-RING finger domain U-box PF04564.10 ESA05451.1 - 2e-06 27.6 0.0 9.5e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-rbx1 PF12678.2 ESA05451.1 - 0.00081 19.4 2.7 0.00081 19.4 1.9 2.5 2 1 0 2 2 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESA05451.1 - 0.0012 18.5 22.6 0.0062 16.2 2.9 4.3 4 0 0 4 4 4 2 RING-type zinc-finger zf-RING_4 PF14570.1 ESA05451.1 - 0.086 12.4 18.9 0.053 13.1 4.0 3.7 3 1 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 ESA05451.1 - 0.58 9.7 20.7 0.23 10.9 4.5 3.5 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.1 ESA05451.1 - 1.3 8.5 19.7 0.029 13.9 4.2 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 UPF0547 PF10571.4 ESA05451.1 - 2 8.1 8.0 23 4.7 0.0 3.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-Apc11 PF12861.2 ESA05451.1 - 6.6 6.6 9.9 0.4 10.5 1.5 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger VPS9 PF02204.13 ESA05452.1 - 0.035 14.1 0.2 0.043 13.8 0.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain Kri1_C PF12936.2 ESA05453.1 - 0.014 15.2 1.2 0.022 14.7 0.9 1.4 1 0 0 1 1 1 0 KRI1-like family C-terminal SAM_1 PF00536.25 ESA05453.1 - 0.071 13.2 0.0 0.21 11.8 0.0 1.9 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) Cas6 PF09559.5 ESA05453.1 - 0.093 12.4 0.1 0.14 11.8 0.0 1.3 1 1 0 1 1 1 0 Cas6 Crispr OmpH PF03938.9 ESA05455.1 - 0.059 13.2 7.7 0.087 12.7 5.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PIH1 PF08190.7 ESA05455.1 - 0.092 12.1 11.2 0.097 12.0 7.8 1.0 1 0 0 1 1 1 0 pre-RNA processing PIH1/Nop17 Radial_spoke_3 PF06098.6 ESA05455.1 - 0.17 10.8 10.8 0.22 10.5 7.5 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 Dynamin_N PF00350.18 ESA05455.1 - 0.28 10.9 4.7 0.35 10.6 3.2 1.1 1 0 0 1 1 1 0 Dynamin family eIF-3_zeta PF05091.7 ESA05455.1 - 0.45 9.0 12.1 0.49 8.9 8.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ctr PF04145.10 ESA05455.1 - 1.2 9.1 4.9 1.7 8.7 3.4 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Mob_Pre PF01076.14 ESA05455.1 - 5.2 6.6 13.1 8.3 5.9 9.1 1.3 1 0 0 1 1 1 0 Plasmid recombination enzyme Ndc1_Nup PF09531.5 ESA05455.1 - 5.5 5.2 10.6 5.8 5.2 7.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.8 ESA05455.1 - 7.7 6.3 17.1 8.7 6.1 11.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UPF0223 PF05256.7 ESA05457.1 - 0.051 13.6 0.9 0.056 13.5 0.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0223) Linker_histone PF00538.14 ESA05457.1 - 0.099 12.7 1.9 0.13 12.3 1.2 1.4 1 1 0 1 1 1 0 linker histone H1 and H5 family EcoR124_C PF12008.3 ESA05457.1 - 0.13 11.3 9.8 0.15 11.2 6.8 1.0 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal Atg14 PF10186.4 ESA05457.1 - 0.15 10.9 11.6 0.17 10.8 8.0 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CDC37_N PF03234.9 ESA05457.1 - 0.46 10.7 7.1 0.47 10.7 4.9 1.0 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF4285 PF14113.1 ESA05457.1 - 0.92 9.5 3.2 0.96 9.4 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4285) Tho2 PF11262.3 ESA05457.1 - 1.1 8.1 8.2 1.3 8.0 5.7 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 RhoGEF PF00621.15 ESA05458.1 - 3.4e-30 105.2 2.8 5.1e-30 104.6 1.9 1.3 1 0 0 1 1 1 1 RhoGEF domain Sec5 PF15469.1 ESA05458.1 - 0.036 13.7 0.1 17 5.0 0.1 2.8 2 1 0 3 3 3 0 Exocyst complex component Sec5 AMP-binding_C_2 PF14535.1 ESA05458.1 - 0.096 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain O-FucT PF10250.4 ESA05459.1 - 0.00029 20.0 0.0 0.00062 18.9 0.0 1.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peptidase_C26 PF07722.8 ESA05459.1 - 0.031 13.7 0.0 0.038 13.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase C26 O-FucT PF10250.4 ESA05461.1 - 0.00019 20.6 0.1 0.00036 19.7 0.1 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peptidase_C26 PF07722.8 ESA05461.1 - 0.03 13.7 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase C26 Laminin_G_3 PF13385.1 ESA05462.1 - 1.4e-08 35.1 0.0 1.7e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Multi_ubiq PF14452.1 ESA05464.1 - 0.08 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Multiubiquitin Aldo_ket_red PF00248.16 ESA05467.1 - 1.3e-45 155.4 0.0 7.4e-31 107.0 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family IDEAL PF08858.5 ESA05468.1 - 0.042 13.3 0.5 0.23 10.9 0.0 2.2 2 0 0 2 2 2 0 IDEAL domain LCD1 PF09798.4 ESA05468.1 - 0.53 8.2 2.4 0.52 8.2 1.6 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein VHS PF00790.14 ESA05469.1 - 8.2e-34 116.2 0.0 9.3e-34 116.0 0.0 1.0 1 0 0 1 1 1 1 VHS domain Pkinase_Tyr PF07714.12 ESA05471.1 - 3.7e-15 55.6 0.0 4.9e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05471.1 - 3.3e-12 46.0 0.0 4.2e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA05474.1 - 1.5e-104 340.0 54.1 5.2e-11 42.8 0.5 16.0 14 2 2 16 16 16 14 Sel1 repeat TPR_6 PF13174.1 ESA05474.1 - 1.2e-06 28.6 20.4 6.6 7.4 0.0 10.2 10 1 0 10 10 10 1 Tetratricopeptide repeat GSH-S_N PF02951.9 ESA05474.1 - 0.00082 19.1 0.0 3.7 7.3 0.0 3.7 3 0 0 3 3 3 2 Prokaryotic glutathione synthetase, N-terminal domain DUF1327 PF07041.6 ESA05474.1 - 0.054 13.3 2.5 3.5 7.5 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1327) UPF0054 PF02130.12 ESA05474.1 - 0.088 12.0 0.9 0.75 9.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein family UPF0054 BTB PF00651.26 ESA05475.1 - 1.2e-06 28.4 0.0 1.4e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Myb_DNA-bind_6 PF13921.1 ESA05476.1 - 9e-05 22.5 4.0 0.0013 18.7 2.8 2.1 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA05476.1 - 0.0031 17.5 1.1 0.72 9.9 0.2 2.6 2 2 0 2 2 2 2 Myb-like DNA-binding domain DUF4485 PF14846.1 ESA05476.1 - 0.031 13.9 0.7 1.4 8.6 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4485) SPASM PF13186.1 ESA05476.1 - 0.036 14.4 2.3 0.04 14.2 0.6 1.8 2 0 0 2 2 2 0 Iron-sulfur cluster-binding domain Myb_DNA-bind_3 PF12776.2 ESA05476.1 - 0.042 14.4 3.7 0.18 12.4 0.9 2.2 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain HTH_29 PF13551.1 ESA05476.1 - 0.059 13.5 0.1 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn helix MbeB_N PF04837.7 ESA05479.1 - 0.026 14.6 28.5 1.8 8.7 1.6 7.0 2 1 5 7 7 7 0 MbeB-like, N-term conserved region HTH_22 PF13309.1 ESA05479.1 - 0.029 14.1 8.7 6.1 6.6 0.0 3.8 3 1 0 3 3 3 0 HTH domain Baculo_PEP_C PF04513.7 ESA05479.1 - 0.039 13.7 11.9 0.12 12.2 0.5 3.0 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cas_Csa5 PF09702.5 ESA05479.1 - 0.039 14.0 10.8 1.5 8.9 0.2 3.5 1 1 3 4 4 4 0 CRISPR-associated protein (Cas_Csa5) GTP_EFTU_D4 PF14578.1 ESA05479.1 - 0.047 13.3 0.1 15 5.3 0.0 2.8 3 0 0 3 3 3 0 Elongation factor Tu domain 4 UPF0227 PF05728.7 ESA05479.1 - 0.048 13.3 9.9 0.021 14.5 2.0 2.7 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0227) Topo-VIb_trans PF09239.6 ESA05479.1 - 0.065 12.7 9.9 1.3 8.5 0.6 3.3 1 1 2 3 3 3 0 Topoisomerase VI B subunit, transducer C-term_anchor PF13461.1 ESA05479.1 - 0.076 13.4 6.6 17 5.9 1.5 4.0 3 2 0 3 3 3 0 Cell-wall surface anchor repeat Nop10p PF04135.7 ESA05479.1 - 0.18 11.5 3.4 36 4.1 0.0 4.5 5 1 1 6 6 6 0 Nucleolar RNA-binding protein, Nop10p family Nup54 PF13874.1 ESA05479.1 - 0.86 9.2 11.5 0.51 10.0 0.9 2.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 nsp9 PF08710.5 ESA05479.1 - 1.2 9.3 9.7 21 5.3 0.2 3.6 1 1 3 4 4 4 0 nsp9 replicase DUF3019 PF11456.3 ESA05479.1 - 1.6 9.0 17.9 2.5 8.4 1.7 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3019) Cation_efflux PF01545.16 ESA05480.1 - 2.6e-26 92.3 0.1 3.1e-26 92.0 0.1 1.0 1 0 0 1 1 1 1 Cation efflux family DUF456 PF04306.8 ESA05480.1 - 0.038 14.0 0.2 0.053 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF456) ACR_tran PF00873.14 ESA05480.1 - 0.076 10.4 0.1 0.092 10.1 0.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family ESCRT-II PF05871.7 ESA05481.1 - 1.6e-47 160.9 0.4 2e-47 160.6 0.3 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit GntR PF00392.16 ESA05481.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family PipA PF07108.6 ESA05482.1 - 0.0044 16.4 1.9 0.06 12.7 0.4 2.5 2 0 0 2 2 2 2 PipA protein Acyl-CoA_dh_M PF02770.14 ESA05484.1 - 2.9e-10 39.4 0.1 5.3e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 ESA05484.1 - 4.3e-07 30.2 0.0 7.4e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_N PF02771.11 ESA05484.1 - 0.073 13.6 0.0 0.41 11.2 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Pkinase_Tyr PF07714.12 ESA05487.1 - 2.8e-25 88.8 0.2 3.5e-25 88.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05487.1 - 3.8e-25 88.5 0.4 4.7e-25 88.2 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA05487.1 - 0.00046 19.3 0.3 0.00068 18.7 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA05487.1 - 0.0023 17.6 0.0 0.0028 17.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA05487.1 - 0.0064 15.7 0.3 0.0097 15.1 0.2 1.3 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA05487.1 - 0.03 13.6 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Docking PF08990.6 ESA05487.1 - 0.093 11.9 0.1 0.21 10.8 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase docking Pkinase_Tyr PF07714.12 ESA05489.1 - 3.9e-46 157.2 0.0 4.8e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05489.1 - 4.2e-43 147.3 0.2 5.4e-43 147.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA05489.1 - 0.016 14.5 0.1 0.033 13.5 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA05489.1 - 0.022 13.8 0.1 0.033 13.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA05489.1 - 0.031 13.5 1.5 0.039 13.1 0.3 1.7 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ESA05489.1 - 0.073 13.7 0.1 0.15 12.7 0.1 1.5 1 0 0 1 1 1 0 Sel1 repeat APH PF01636.18 ESA05489.1 - 0.086 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family O-FucT PF10250.4 ESA05491.1 - 0.0022 17.1 0.1 0.051 12.6 0.1 2.2 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Chlam_vir PF05475.6 ESA05493.1 - 0.29 10.1 4.7 0.56 9.2 1.0 2.3 1 1 1 2 2 2 0 Chlamydia virulence protein PGP3-D SseC PF04888.7 ESA05493.1 - 0.47 9.7 4.7 1 8.6 3.3 1.5 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Lipase_3 PF01764.20 ESA05494.1 - 6.1e-24 84.2 0.0 1.2e-23 83.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA05494.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA05494.1 - 0.19 11.6 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family HemX PF04375.9 ESA05494.1 - 0.25 9.8 0.0 0.35 9.3 0.0 1.1 1 0 0 1 1 1 0 HemX Pol_alpha_B_N PF08418.5 ESA05494.1 - 1.4 8.3 5.2 2.4 7.6 3.4 1.5 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal DUF605 PF04652.11 ESA05494.1 - 2.8 7.2 5.7 4 6.7 3.9 1.2 1 0 0 1 1 1 0 Vta1 like Spectrin PF00435.16 ESA05496.1 - 0.14 12.4 3.6 0.15 12.3 1.0 2.1 1 1 0 1 1 1 0 Spectrin repeat DUF4164 PF13747.1 ESA05496.1 - 0.75 9.9 7.1 4.5 7.4 0.9 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) COG5 PF10392.4 ESA05496.1 - 1 9.3 9.1 0.7 9.8 4.6 2.0 1 1 0 1 1 1 0 Golgi transport complex subunit 5 STAG PF08514.6 ESA05496.1 - 1.4 8.6 12.6 0.68 9.6 0.4 3.7 2 2 1 3 3 3 0 STAG domain DUF3349 PF11829.3 ESA05496.1 - 1.4 9.3 3.3 29 5.1 0.1 3.0 1 1 3 4 4 4 0 Protein of unknown function (DUF3349) IncA PF04156.9 ESA05496.1 - 1.5 8.3 3.6 2.6 7.5 1.7 2.0 1 1 1 2 2 2 0 IncA protein PhoU PF01895.14 ESA05496.1 - 4.8 7.7 21.5 4.5 7.7 8.4 2.8 2 1 0 2 2 2 0 PhoU domain DUF1461 PF07314.6 ESA05496.1 - 5.6 6.6 15.8 0.29 10.8 0.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1461) UXS1_N PF11803.3 ESA05496.1 - 6.8 6.5 7.5 1.2 9.0 0.6 2.8 3 0 0 3 3 3 0 UDP-glucuronate decarboxylase N-terminal NAD_binding_6 PF08030.7 ESA05496.1 - 9 6.1 7.5 43 3.9 5.0 2.0 1 1 1 2 2 2 0 Ferric reductase NAD binding domain DUF745 PF05335.8 ESA05497.1 - 0.019 14.5 0.6 0.029 13.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) ComK PF06338.6 ESA05497.1 - 0.038 13.4 0.2 0.066 12.6 0.2 1.4 1 1 0 1 1 1 0 ComK protein P4Ha_N PF08336.6 ESA05497.1 - 1.8 8.3 6.3 0.54 10.0 2.2 1.7 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Syntaxin-6_N PF09177.6 ESA05497.1 - 5.1 7.5 7.5 16 5.9 4.3 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Ubie_methyltran PF01209.13 ESA05500.1 - 0.018 14.1 0.3 0.024 13.7 0.2 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF3855 PF12967.2 ESA05500.1 - 0.061 12.8 0.3 0.083 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) DUF3287 PF11690.3 ESA05503.1 - 3.5 7.7 14.1 1.7 8.7 1.2 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF3287) BcrAD_BadFG PF01869.15 ESA05504.1 - 8.5e-06 25.2 0.0 0.00012 21.4 0.0 2.1 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family MreB_Mbl PF06723.8 ESA05504.1 - 0.00029 19.5 0.0 0.27 9.7 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein zf-RING_5 PF14634.1 ESA05505.1 - 1.5e-08 34.2 6.7 1.5e-08 34.2 4.6 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA05505.1 - 6.3e-08 32.1 5.9 6.3e-08 32.1 4.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA05505.1 - 1.8e-07 30.8 6.5 1.8e-07 30.8 4.5 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.20 ESA05505.1 - 3e-07 29.9 6.3 3e-07 29.9 4.3 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 ESA05505.1 - 1.3e-05 24.7 5.1 1.3e-05 24.7 3.5 2.6 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 ESA05505.1 - 1.3e-05 24.9 3.4 1.3e-05 24.9 2.3 2.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 ESA05505.1 - 2.4e-05 24.2 4.1 2.4e-05 24.2 2.8 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.19 ESA05505.1 - 9.8e-05 21.9 16.5 0.0017 17.9 1.8 2.9 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESA05505.1 - 0.00043 20.1 12.0 0.016 15.1 1.1 3.5 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type zf-RING_6 PF14835.1 ESA05505.1 - 0.0023 17.6 1.2 0.0023 17.6 0.9 2.0 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESA05505.1 - 0.0048 16.5 3.8 0.0061 16.2 1.2 2.4 1 1 1 2 2 2 1 RING-type zinc-finger Baculo_RING PF05883.6 ESA05505.1 - 0.013 15.3 4.5 0.071 12.9 3.1 2.2 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-MIZ PF02891.15 ESA05505.1 - 0.021 14.3 4.0 0.021 14.3 2.8 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.2 ESA05505.1 - 0.047 13.7 9.8 0.19 11.8 6.8 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger zf-CCHH PF10283.4 ESA05505.1 - 0.78 9.6 7.8 3.5 7.5 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger (CX5CX6HX5H) motif DUF3072 PF11272.3 ESA05506.1 - 0.00025 20.6 0.0 9.5 5.9 0.0 4.6 5 0 0 5 5 5 3 Protein of unknown function (DUF3072) HypA PF01155.14 ESA05506.1 - 0.00056 19.5 29.5 2.3 7.9 0.1 8.2 8 0 0 8 8 8 6 Hydrogenase expression/synthesis hypA family Hist_deacetyl PF00850.14 ESA05508.1 - 7e-47 160.2 0.0 8.5e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain EST1 PF10374.4 ESA05509.1 - 0.1 12.5 0.7 0.12 12.3 0.5 1.1 1 0 0 1 1 1 0 Telomerase activating protein Est1 WRKY PF03106.10 ESA05511.1 - 0.0004 20.1 4.1 0.00092 19.0 2.9 1.6 1 0 0 1 1 1 1 WRKY DNA -binding domain DUF1294 PF06961.8 ESA05511.1 - 0.14 12.1 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Salp15 PF12115.3 ESA05512.1 - 0.13 12.5 7.7 0.28 11.4 1.1 2.6 3 0 0 3 3 3 0 Salivary protein of 15kDa inhibits CD4+ T cell activation TLD PF07534.11 ESA05515.1 - 9.1e-14 51.6 0.7 1.9e-13 50.6 0.5 1.5 1 0 0 1 1 1 1 TLD DUF1108 PF06531.6 ESA05516.1 - 0.47 10.6 4.2 0.15 12.2 0.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1108) CD36 PF01130.16 ESA05517.1 - 0.016 13.5 0.9 0.021 13.1 0.6 1.2 1 0 0 1 1 1 0 CD36 family ASXH PF13919.1 ESA05517.1 - 0.23 11.2 0.2 0.23 11.2 0.1 2.3 1 1 1 2 2 2 0 Asx homology domain DUF4618 PF15397.1 ESA05518.1 - 0.0002 20.8 0.0 6.5 6.0 0.0 3.2 3 0 0 3 3 3 3 Domain of unknown function (DUF4618) DUF2789 PF10982.3 ESA05518.1 - 0.0026 17.7 8.5 3.4 7.7 0.2 3.6 3 0 0 3 3 3 3 Protein of unknown function (DUF2789) Methyltransf_15 PF09445.5 ESA05518.1 - 0.036 13.6 12.0 0.75 9.3 0.7 3.1 2 1 1 3 3 3 0 RNA cap guanine-N2 methyltransferase TraT PF05818.7 ESA05518.1 - 0.075 12.4 2.3 7.2 5.9 0.1 2.8 3 0 0 3 3 3 0 Enterobacterial TraT complement resistance protein DUF2408 PF10303.4 ESA05518.1 - 0.24 11.4 7.9 2.8 8.0 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) UDG PF03167.14 ESA05520.1 - 1.1e-10 41.1 0.0 1.4e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DNA_pol_B_exo2 PF10108.4 ESA05520.1 - 0.011 15.2 0.1 0.017 14.6 0.1 1.3 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DUF4284 PF14112.1 ESA05520.1 - 0.85 10.1 7.9 0.12 12.8 2.3 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4284) DUF940 PF06082.6 ESA05521.1 - 0.034 12.6 0.0 0.039 12.5 0.0 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Arb2 PF09757.4 ESA05522.1 - 3e-18 65.8 0.0 4e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Arb2 domain HAD_2 PF13419.1 ESA05523.1 - 1.9e-16 60.8 0.0 2.6e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA05523.1 - 5.3e-05 22.8 0.0 8.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESA05523.1 - 0.093 13.1 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Glycos_transf_1 PF00534.15 ESA05524.1 - 7.5e-13 48.2 0.0 1.9e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 eIF3g PF12353.3 ESA05525.1 - 2.4e-43 147.0 3.8 3.6e-43 146.5 2.6 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 ESA05525.1 - 2.6e-17 62.2 0.2 1.2e-16 60.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA05525.1 - 2e-11 43.7 0.0 4.1e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA05525.1 - 1.2e-08 34.6 0.0 4.3e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 ESA05526.1 - 1.4e-35 122.6 5.2 5.8e-25 87.9 0.2 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05526.1 - 1.2e-13 50.7 0.7 1.2e-11 44.1 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 ESA05526.1 - 0.1 11.9 1.3 0.2 10.9 0.1 2.1 2 0 0 2 2 2 0 RIO1 family NARP1 PF12569.3 ESA05526.1 - 0.69 8.6 6.0 1.2 7.8 4.2 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Isochorismatase PF00857.15 ESA05527.1 - 7.8e-33 113.8 0.0 1.1e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family DUF2761 PF10959.3 ESA05527.1 - 0.016 14.7 0.1 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2761) DUF2730 PF10805.3 ESA05528.1 - 0.033 13.9 0.1 10 5.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) NPHI_C PF08469.5 ESA05529.1 - 0.12 12.3 1.3 0.23 11.3 0.9 1.5 1 1 0 1 1 1 0 Nucleoside triphosphatase I C-terminal CobD_Cbib PF03186.8 ESA05531.1 - 0.054 12.5 0.2 0.064 12.3 0.1 1.1 1 0 0 1 1 1 0 CobD/Cbib protein CRPA PF05745.6 ESA05531.1 - 1.4 8.7 8.5 1.8 8.3 5.9 1.2 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Chitin_synth_1 PF01644.12 ESA05533.1 - 1.7e-80 268.5 0.5 2.4e-80 268.0 0.4 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.10 ESA05533.1 - 6.9e-27 94.0 0.6 1.1e-22 80.1 0.0 2.5 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA05533.1 - 3.2e-11 43.2 0.3 3.2e-11 43.2 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA05533.1 - 3.5e-06 26.9 0.0 5.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Trigger_N PF05697.8 ESA05533.1 - 0.24 11.2 5.1 1.3 8.7 0.9 2.2 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) Glycos_transf_2 PF00535.21 ESA05535.1 - 4.7e-08 32.8 0.3 7.6e-05 22.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferase family 2 DUF1829 PF08862.5 ESA05536.1 - 0.041 14.1 0.3 0.26 11.5 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function DUF1829 DNA_methylase PF00145.12 ESA05537.1 - 1.2e-29 103.5 0.1 1.9e-29 102.8 0.1 1.3 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.13 ESA05537.1 - 6.9e-13 48.4 3.0 2.5e-07 30.4 0.1 2.5 2 0 0 2 2 2 2 BAH domain DNMT1-RFD PF12047.3 ESA05537.1 - 4e-05 23.3 1.4 9e-05 22.1 1.0 1.6 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain CUE PF02845.11 ESA05538.1 - 1.2e-13 50.2 0.1 2.4e-13 49.2 0.1 1.6 1 0 0 1 1 1 1 CUE domain DUF573 PF04504.9 ESA05538.1 - 0.024 14.9 1.4 0.075 13.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF573 Evr1_Alr PF04777.8 ESA05539.1 - 4.6e-30 103.3 0.4 5.3e-30 103.1 0.3 1.0 1 0 0 1 1 1 1 Erv1 / Alr family DUF3567 PF12091.3 ESA05539.1 - 0.037 14.0 0.0 0.18 11.8 0.0 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3567) Herpes_UL69 PF05459.7 ESA05539.1 - 0.038 13.1 0.1 0.36 9.9 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus transcriptional regulator family NUDIX PF00293.23 ESA05540.1 - 9.5e-19 67.3 0.0 1.5e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Amidase PF01425.16 ESA05541.1 - 6e-106 354.9 0.0 7.7e-106 354.5 0.0 1.1 1 0 0 1 1 1 1 Amidase GYF PF02213.11 ESA05542.1 - 6.4e-12 44.8 0.2 1.6e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 GYF domain Conotoxin PF02950.12 ESA05544.1 - 0.0054 17.5 0.1 0.0065 17.2 0.1 1.2 1 0 0 1 1 1 1 Conotoxin Tetraspannin PF00335.15 ESA05544.1 - 0.013 14.7 0.0 0.015 14.6 0.0 1.0 1 0 0 1 1 1 0 Tetraspanin family DUF4179 PF13786.1 ESA05544.1 - 0.062 13.5 0.4 0.067 13.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) GRP PF07172.6 ESA05544.1 - 0.066 13.7 0.0 0.079 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family DUF2673 PF10880.3 ESA05544.1 - 0.12 12.4 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) Sugarporin_N PF11471.3 ESA05544.1 - 0.2 11.3 0.6 0.28 10.8 0.4 1.3 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension DUF1003 PF06210.6 ESA05544.1 - 0.24 11.3 2.5 0.33 10.8 1.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1003) GST_C PF00043.20 ESA05546.1 - 1.5e-15 56.9 0.0 2.7e-15 56.1 0.0 1.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA05546.1 - 5.2e-08 32.6 0.0 7.7e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA05546.1 - 5.3e-07 30.0 0.0 8e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase PF00069.20 ESA05547.1 - 5.7e-31 107.6 0.1 5.9e-31 107.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05547.1 - 5.6e-30 104.2 0.0 6.3e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA05547.1 - 0.0012 18.6 0.1 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA05547.1 - 0.016 14.5 0.0 0.02 14.2 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA05547.1 - 0.028 13.4 0.8 0.11 11.4 0.2 1.8 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA05549.1 - 1.9e-34 118.8 0.4 5.7e-33 114.0 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA05549.1 - 2.8e-30 105.3 11.1 2e-28 99.2 4.5 2.9 2 1 0 2 2 2 2 Protein kinase domain B PF02216.11 ESA05549.1 - 0.47 10.2 4.0 0.35 10.6 1.2 2.1 2 0 0 2 2 2 0 B domain SWIRM PF04433.12 ESA05550.1 - 1.3e-12 47.6 0.0 2.8e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Thr_dehydrat_C PF00585.13 ESA05551.1 - 0.041 13.4 0.2 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase VIT1 PF01988.14 ESA05552.1 - 2.3e-32 112.2 0.3 2.5e-32 112.0 0.2 1.0 1 0 0 1 1 1 1 VIT family Toxin_53 PF15532.1 ESA05553.1 - 0.078 13.1 0.1 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative toxin 53 Gly_transf_sug PF04488.10 ESA05555.1 - 6.9e-09 36.0 1.3 1.5e-08 34.9 0.2 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 ESA05555.1 - 3.6e-08 32.8 0.8 6.6e-08 32.0 0.1 1.7 1 1 1 2 2 2 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 ESA05555.1 - 8.6e-05 21.2 0.0 0.00014 20.5 0.0 1.3 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain CDRN PF05174.7 ESA05555.1 - 0.42 10.1 1.6 1.5 8.3 0.1 2.4 2 0 0 2 2 2 0 Cysteine-rich D. radiodurans N terminus Prothymosin PF03247.9 ESA05556.1 - 1.4 9.1 16.4 1.5 8.9 11.4 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family ARID PF01388.16 ESA05557.1 - 1.6e-25 88.7 0.0 4.6e-25 87.2 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain TerD PF02342.13 ESA05557.1 - 0.2 10.9 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 TerD domain Dimer_Tnp_hAT PF05699.9 ESA05559.1 - 6.1e-09 35.3 0.2 1.4e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region RasGEF PF00617.14 ESA05560.1 - 4.1e-48 163.6 0.8 8.6e-48 162.5 0.5 1.6 1 1 0 1 1 1 1 RasGEF domain DUF4417 PF14386.1 ESA05560.1 - 0.015 14.6 0.3 0.038 13.3 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4417) RasGEF_N PF00618.15 ESA05560.1 - 0.015 15.3 2.7 0.032 14.3 0.3 2.6 2 0 0 2 2 2 0 RasGEF N-terminal motif MatP PF06303.7 ESA05560.1 - 0.23 11.3 3.3 6.7 6.6 0.1 2.5 2 0 0 2 2 2 0 Organiser of macrodomain of Terminus of chromosome Med12-LCEWAV PF12145.3 ESA05561.1 - 0.42 9.0 3.6 0.53 8.7 2.5 1.1 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain YfhO PF09586.5 ESA05561.1 - 0.8 7.6 7.0 0.99 7.3 4.8 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO FAD_binding_4 PF01565.18 ESA05562.1 - 6.6e-29 100.1 4.2 1e-28 99.5 2.9 1.3 1 0 0 1 1 1 1 FAD binding domain ER_lumen_recept PF00810.13 ESA05563.1 - 3.6e-58 196.2 12.4 6.3e-58 195.4 8.6 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.9 ESA05563.1 - 0.024 14.1 14.0 0.14 11.7 0.1 3.9 4 1 1 5 5 5 0 PQ loop repeat Herpes_U15 PF05613.6 ESA05563.1 - 1.1 9.6 6.9 0.48 10.7 1.9 2.3 1 1 0 2 2 2 0 Human herpesvirus U15 protein LRR_4 PF12799.2 ESA05564.1 - 1e-18 66.4 24.4 5.9e-08 32.1 1.1 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 ESA05564.1 - 2.6e-13 49.9 0.6 4.5e-13 49.1 0.4 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 ESA05564.1 - 6.9e-08 32.1 13.3 3.8e-07 29.7 4.2 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 ESA05564.1 - 2e-07 30.0 5.2 1.1 9.7 0.0 4.9 4 0 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.1 ESA05564.1 - 7.8e-07 28.5 8.4 0.045 13.8 0.4 4.4 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.28 ESA05564.1 - 1.1e-06 27.7 7.5 0.036 14.0 0.5 4.6 4 0 0 4 4 4 3 Leucine Rich Repeat COG4 PF08318.7 ESA05565.1 - 1.8e-81 273.5 7.7 1.8e-81 273.5 5.4 2.0 2 0 0 2 2 2 1 COG4 transport protein PhoU_div PF01865.11 ESA05565.1 - 0.0094 15.1 10.0 0.12 11.4 0.1 4.0 4 0 0 4 4 4 2 Protein of unknown function DUF47 rve_3 PF13683.1 ESA05565.1 - 0.034 13.6 0.0 0.098 12.1 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain FlxA PF14282.1 ESA05566.1 - 0.037 13.9 0.3 0.043 13.7 0.2 1.2 1 0 0 1 1 1 0 FlxA-like protein Tox-ART-HYE1 PF15634.1 ESA05566.1 - 0.08 11.9 1.3 0.091 11.7 0.9 1.1 1 0 0 1 1 1 0 HYE1 signature containing ADP-ribosyltransferase Antimicrobial_7 PF08102.6 ESA05566.1 - 0.21 11.6 0.9 0.54 10.3 0.3 2.0 1 1 1 2 2 2 0 Scorpion antimicrobial peptide Vac14_Fig4_bd PF11916.3 ESA05568.1 - 0.025 13.7 0.6 0.13 11.4 0.1 2.0 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding MFS_2 PF13347.1 ESA05570.1 - 1.6e-08 33.3 24.8 1.2e-07 30.5 17.1 2.3 2 1 0 2 2 2 1 MFS/sugar transport protein PUCC PF03209.10 ESA05570.1 - 2.4e-05 23.2 4.0 4e-05 22.5 2.8 1.3 1 0 0 1 1 1 1 PUCC protein DUF3169 PF11368.3 ESA05570.1 - 0.23 10.6 8.6 3.2 6.8 0.0 3.6 2 1 1 4 4 4 0 Protein of unknown function (DUF3169) MFS_1_like PF12832.2 ESA05570.1 - 1 9.2 0.0 1 9.2 0.0 4.4 6 0 0 6 6 6 0 MFS_1 like family Mob_Pre PF01076.14 ESA05571.1 - 2.2e-29 102.5 4.5 1.1e-14 54.5 0.0 3.0 2 2 1 3 3 3 2 Plasmid recombination enzyme DDE_Tnp_IS1 PF03400.8 ESA05571.1 - 0.013 15.6 0.1 0.027 14.6 0.1 1.5 1 0 0 1 1 1 0 IS1 transposase Rep_1 PF01446.12 ESA05572.1 - 7.1e-50 169.5 1.9 8.1e-50 169.3 1.3 1.0 1 0 0 1 1 1 1 Replication protein DUF3296 PF11726.3 ESA05572.1 - 0.058 12.9 0.3 0.095 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3296) ubiquitin PF00240.18 ESA05574.1 - 3.3e-21 74.4 0.3 6e-21 73.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA05574.1 - 1.4e-09 37.4 0.1 2.9e-09 36.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA05574.1 - 0.00036 20.7 0.0 0.00076 19.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain PARP PF00644.15 ESA05574.1 - 0.0018 17.7 0.1 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain NIF PF03031.13 ESA05575.1 - 1.3e-26 93.1 0.1 1.1e-21 77.1 0.0 2.4 1 1 1 2 2 2 2 NLI interacting factor-like phosphatase eIF-5_eIF-2B PF01873.12 ESA05576.1 - 0.025 14.2 0.3 0.034 13.8 0.2 1.3 1 1 0 1 1 1 0 Domain found in IF2B/IF5 DUF3797 PF12677.2 ESA05576.1 - 0.11 12.0 0.5 0.2 11.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) HEAT PF02985.17 ESA05577.1 - 1.2e-14 52.9 11.7 0.036 14.1 0.0 9.1 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.1 ESA05577.1 - 4.1e-08 33.3 8.8 0.015 15.5 0.0 6.8 4 2 2 7 7 7 2 HEAT repeats HEAT_EZ PF13513.1 ESA05577.1 - 0.0036 17.7 9.8 0.65 10.5 0.1 5.8 5 1 1 6 6 6 1 HEAT-like repeat Cnd1 PF12717.2 ESA05577.1 - 0.025 14.4 0.0 17 5.1 0.0 3.8 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 ESA05577.1 - 0.03 12.6 1.5 0.51 8.6 0.0 2.7 3 0 0 3 3 3 0 Adaptin N terminal region 7TM-7TMR_HD PF07698.6 ESA05577.1 - 0.041 13.3 0.1 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase PAT1 PF09770.4 ESA05577.1 - 2.3 6.3 8.8 3.1 5.9 6.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SPRY PF00622.23 ESA05578.1 - 1.1e-09 38.3 0.4 1.8e-09 37.7 0.2 1.2 1 0 0 1 1 1 1 SPRY domain MRF_C2 PF13888.1 ESA05578.1 - 0.082 12.7 0.1 0.25 11.1 0.0 1.8 1 1 1 2 2 2 0 Myelin gene regulatory factor C-terminal domain 2 CENP-L PF13092.1 ESA05579.1 - 1e-12 48.1 0.2 1.5e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 F-box-like PF12937.2 ESA05580.1 - 0.0016 18.0 0.4 0.005 16.5 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA05580.1 - 0.054 13.1 0.5 0.58 9.8 0.2 2.9 2 1 0 2 2 2 0 F-box domain QueF PF14489.1 ESA05580.1 - 0.22 11.4 2.4 2.3 8.2 0.7 2.9 2 1 0 2 2 2 0 QueF-like protein Zn_clus PF00172.13 ESA05582.1 - 4.6e-08 32.8 12.1 9.7e-08 31.7 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.20 ESA05583.1 - 3.7e-05 23.0 0.0 4.3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05583.1 - 0.00072 18.7 0.0 0.00088 18.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase F-box-like PF12937.2 ESA05584.1 - 0.026 14.2 0.1 0.068 12.8 0.1 1.7 1 0 0 1 1 1 0 F-box-like SR-25 PF10500.4 ESA05584.1 - 6.5 6.1 7.3 11 5.3 5.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MaoC_dehydratas PF01575.14 ESA05585.1 - 7.2e-15 54.4 0.0 1.5e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 ESA05585.1 - 1.8e-08 34.2 0.0 1.8e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase MRJP PF03022.11 ESA05586.1 - 0.02 14.0 0.2 0.021 14.0 0.1 1.0 1 0 0 1 1 1 0 Major royal jelly protein Sel1 PF08238.7 ESA05587.1 - 1.4e-159 515.0 66.0 8.4e-12 45.3 0.1 15.1 15 0 0 15 15 15 15 Sel1 repeat TPR_6 PF13174.1 ESA05587.1 - 2.2e-05 24.6 36.7 6.8 7.3 0.1 12.7 13 1 0 13 13 13 3 Tetratricopeptide repeat MIF PF01187.13 ESA05587.1 - 0.00074 19.5 3.0 1.3e+02 2.6 0.0 6.7 7 1 0 7 7 7 0 Macrophage migration inhibitory factor (MIF) Shikimate_dh_N PF08501.6 ESA05587.1 - 0.047 13.7 1.2 26 4.9 0.0 4.5 4 1 1 5 5 5 0 Shikimate dehydrogenase substrate binding domain Curlin_rpt PF07012.7 ESA05587.1 - 1 9.1 5.4 15 5.3 0.1 3.1 3 0 0 3 3 3 0 Curlin associated repeat TLE_N PF03920.10 ESA05587.1 - 5.3 6.8 7.9 16 5.3 0.1 4.2 2 1 1 4 4 4 0 Groucho/TLE N-terminal Q-rich domain Sel1 PF08238.7 ESA05590.1 - 1.1e-172 556.6 91.5 2.6e-11 43.7 0.1 21.6 22 0 0 22 22 22 21 Sel1 repeat Pkinase_Tyr PF07714.12 ESA05590.1 - 3.8e-49 167.0 0.1 5.7e-49 166.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05590.1 - 5.2e-47 160.1 1.0 5.2e-47 160.1 0.7 1.7 1 1 1 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA05590.1 - 3.9e-07 30.0 39.3 0.56 10.7 0.0 14.0 15 2 0 15 15 15 2 Tetratricopeptide repeat RIO1 PF01163.17 ESA05590.1 - 2.2e-05 23.8 0.2 6.6e-05 22.3 0.2 1.8 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA05590.1 - 0.00031 19.8 0.1 0.00058 18.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA05590.1 - 0.00058 18.9 0.0 0.0012 17.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA05590.1 - 0.013 15.1 0.1 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family SLBB PF10531.4 ESA05590.1 - 0.039 13.8 1.7 60 3.6 0.0 4.5 5 0 0 5 5 5 0 SLBB domain Shugoshin_N PF07558.6 ESA05591.1 - 0.099 12.3 0.4 2.9 7.6 0.1 2.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TMEM95 PF15203.1 ESA05592.1 - 0.082 12.3 0.3 0.1 12.0 0.2 1.3 1 1 0 1 1 1 0 TMEM95 family DUF87 PF01935.12 ESA05596.1 - 0.00087 19.1 1.0 0.00097 19.0 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF87 Syntaxin-6_N PF09177.6 ESA05596.1 - 0.18 12.2 1.3 0.3 11.5 0.4 1.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HMG_box PF00505.14 ESA05597.1 - 0.0053 17.0 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA05597.1 - 0.096 12.0 0.2 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 Transformer PF06495.6 ESA05598.1 - 1.6 8.5 14.8 2.2 8.1 10.3 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein Corona_nucleoca PF00937.13 ESA05598.1 - 4 6.3 20.6 4.8 6.0 14.3 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein PigN PF04987.9 ESA05599.1 - 3e-24 85.4 6.6 4e-24 85.0 4.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Baculo_helicase PF04735.7 ESA05602.1 - 0.035 11.4 0.3 0.07 10.4 0.1 1.5 1 1 1 2 2 2 0 Baculovirus DNA helicase Rubredoxin PF00301.15 ESA05602.1 - 0.13 12.1 1.9 0.22 11.4 1.3 1.3 1 0 0 1 1 1 0 Rubredoxin Ndc1_Nup PF09531.5 ESA05603.1 - 0.54 8.6 6.7 0.6 8.4 4.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NST1 PF13945.1 ESA05603.1 - 1.1 9.2 5.8 1.2 9.1 4.0 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.4 ESA05603.1 - 2 6.5 7.4 2.3 6.3 5.1 1.1 1 0 0 1 1 1 0 Transmembrane protein Presenilin PF01080.12 ESA05603.1 - 3 6.5 5.6 3.2 6.4 3.9 1.0 1 0 0 1 1 1 0 Presenilin Ribosomal_L28e PF01778.12 ESA05604.1 - 0.1 12.9 0.1 0.11 12.8 0.1 1.1 1 0 0 1 1 1 0 Ribosomal L28e protein family Cu_bind_like PF02298.12 ESA05607.1 - 3.7e-05 23.4 0.1 0.00012 21.8 0.0 1.8 2 0 0 2 2 2 1 Plastocyanin-like domain Gram_pos_anchor PF00746.16 ESA05607.1 - 0.18 11.6 1.1 0.49 10.2 0.8 1.8 1 0 0 1 1 1 0 Gram positive anchor Arch_ATPase PF01637.13 ESA05608.1 - 1.7e-08 34.4 10.2 2.5e-08 33.9 7.1 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESA05608.1 - 3.1e-05 24.1 0.8 0.00039 20.5 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 ESA05608.1 - 6.8e-05 23.0 1.5 0.00014 22.0 0.2 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA05608.1 - 0.00084 19.3 0.0 0.0048 16.8 0.0 1.9 1 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 ESA05608.1 - 0.0014 18.9 0.3 0.002 18.3 0.2 1.6 1 1 0 1 1 1 1 ABC transporter DUF258 PF03193.11 ESA05608.1 - 0.0016 17.6 0.0 0.0035 16.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 ESA05608.1 - 0.0019 17.8 0.0 0.0038 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 ESA05608.1 - 0.0025 18.2 0.6 0.023 15.1 0.4 2.3 1 1 0 1 1 1 1 Miro-like protein Peptidase_C71 PF12386.3 ESA05608.1 - 0.008 15.6 1.8 0.046 13.1 0.6 2.4 2 0 0 2 2 2 1 Pseudomurein endo-isopeptidase Pei NACHT PF05729.7 ESA05608.1 - 0.0091 15.6 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.1 ESA05608.1 - 0.018 14.9 8.4 0.38 10.6 5.8 2.7 1 1 0 1 1 1 0 AAA domain rve_2 PF13333.1 ESA05608.1 - 0.019 15.0 0.6 0.019 15.0 0.4 2.8 4 0 0 4 4 2 0 Integrase core domain RNA_helicase PF00910.17 ESA05608.1 - 0.027 14.6 1.0 0.16 12.1 0.5 2.3 1 1 0 1 1 1 0 RNA helicase UPF0079 PF02367.12 ESA05608.1 - 0.028 14.0 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NB-ARC PF00931.17 ESA05608.1 - 0.039 12.8 0.5 0.078 11.8 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.10 ESA05608.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 NTPase T2SE PF00437.15 ESA05608.1 - 0.056 12.3 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.14 ESA05608.1 - 0.064 12.7 0.2 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DAP3 PF10236.4 ESA05608.1 - 0.11 11.4 2.5 0.22 10.4 0.0 2.0 1 1 1 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_11 PF13086.1 ESA05608.1 - 0.11 11.9 0.1 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 ESA05608.1 - 0.12 11.8 0.6 0.21 11.0 0.4 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.1 ESA05608.1 - 0.47 10.7 4.1 2 8.7 2.8 2.1 1 1 0 1 1 1 0 AAA domain RloB PF13707.1 ESA05609.1 - 0.12 11.9 0.6 0.15 11.7 0.4 1.4 1 1 0 1 1 1 0 RloB-like protein UDPGT PF00201.13 ESA05610.1 - 7.6e-33 113.8 0.0 1.2e-32 113.1 0.0 1.3 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA05610.1 - 2.2e-07 30.7 0.1 4.2e-07 29.7 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA05610.1 - 0.00026 20.3 0.0 0.00055 19.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 1 LUC7 PF03194.10 ESA05610.1 - 0.066 12.7 0.2 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 LUC7 N_terminus Lipase_GDSL_2 PF13472.1 ESA05611.1 - 1.8e-05 24.9 0.0 2e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESA05611.1 - 0.00014 21.7 0.1 0.0003 20.6 0.1 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Mpv17_PMP22 PF04117.7 ESA05612.1 - 5.8e-11 41.8 0.3 1.9e-10 40.2 0.3 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family Pkinase PF00069.20 ESA05616.1 - 8.8e-20 70.9 1.4 5.1e-18 65.1 0.2 3.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05616.1 - 7e-19 67.8 0.0 3.7e-16 58.9 0.0 3.0 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA05616.1 - 0.041 13.6 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1785 PF08699.5 ESA05617.1 - 8e-05 21.9 0.0 0.00015 21.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Pkinase_Tyr PF07714.12 ESA05622.1 - 1.4e-14 53.7 0.8 1.6e-14 53.5 0.5 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05622.1 - 9.4e-10 38.0 2.4 1.1e-09 37.8 1.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA05622.1 - 0.0079 15.2 0.4 0.01 14.9 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3091 PF11291.3 ESA05623.1 - 0.016 15.1 0.9 0.033 14.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) RRM_1 PF00076.17 ESA05623.1 - 0.07 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.12 ESA05625.1 - 0.00093 18.3 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05625.1 - 0.026 13.7 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Toxin_21 PF08091.6 ESA05625.1 - 0.11 12.2 0.3 0.19 11.4 0.2 1.4 1 0 0 1 1 1 0 Spider insecticidal peptide TMEM223 PF14640.1 ESA05631.1 - 1e-08 35.3 0.1 1.3e-08 34.9 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 223 AAA PF00004.24 ESA05633.1 - 1e-97 323.4 0.0 8.4e-48 161.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA05633.1 - 8.7e-14 51.1 0.0 1.2e-05 24.4 0.0 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ESA05633.1 - 2.5e-13 50.2 0.0 2.5e-07 30.7 0.0 3.6 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 ESA05633.1 - 5.9e-13 49.7 0.2 4e-05 24.4 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESA05633.1 - 9e-13 48.1 0.1 5e-06 26.2 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESA05633.1 - 2.1e-12 47.1 0.0 6.1e-06 26.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.12 ESA05633.1 - 1.3e-11 43.9 0.0 2.9e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.1 ESA05633.1 - 1.6e-11 44.4 0.1 0.0015 18.6 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESA05633.1 - 3.9e-11 43.2 0.0 0.00048 20.1 0.0 3.2 2 2 0 2 2 2 2 AAA ATPase domain TIP49 PF06068.8 ESA05633.1 - 6.1e-09 35.0 0.1 0.00044 19.0 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 ESA05633.1 - 9.8e-09 35.1 0.0 0.003 17.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 ESA05633.1 - 1.5e-08 33.9 0.0 0.0047 16.0 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 ESA05633.1 - 1.2e-07 31.3 1.6 0.041 13.2 0.0 3.5 2 2 1 3 3 3 2 AAA domain IstB_IS21 PF01695.12 ESA05633.1 - 1.2e-07 31.3 0.0 0.01 15.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESA05633.1 - 1.4e-07 30.8 0.2 0.014 14.5 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 ESA05633.1 - 1.5e-07 31.5 0.0 0.004 17.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 ESA05633.1 - 4.7e-07 29.4 0.9 0.03 14.0 0.3 2.8 2 0 0 2 2 2 2 Part of AAA domain ABC_tran PF00005.22 ESA05633.1 - 5.6e-07 29.9 0.0 0.0052 17.0 0.0 3.3 2 1 0 2 2 2 2 ABC transporter AAA_18 PF13238.1 ESA05633.1 - 5.6e-07 29.9 0.1 0.051 13.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.1 ESA05633.1 - 1.8e-06 28.0 0.1 0.095 12.6 0.0 3.0 3 0 0 3 3 3 2 AAA domain Vps4_C PF09336.5 ESA05633.1 - 2.4e-06 27.3 0.1 3e-05 23.8 0.0 2.7 2 1 0 2 2 2 1 Vps4 C terminal oligomerisation domain Arch_ATPase PF01637.13 ESA05633.1 - 2.4e-06 27.4 0.1 0.29 10.8 0.0 3.4 2 1 1 3 3 3 1 Archaeal ATPase KaiC PF06745.8 ESA05633.1 - 3.3e-06 26.4 0.4 0.43 9.6 0.0 3.3 2 1 1 3 3 3 2 KaiC Parvo_NS1 PF01057.12 ESA05633.1 - 3.3e-06 26.1 0.1 0.025 13.4 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ResIII PF04851.10 ESA05633.1 - 1.7e-05 24.7 0.0 0.0037 17.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.21 ESA05633.1 - 2.9e-05 23.5 0.0 0.23 10.8 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 ESA05633.1 - 3.2e-05 23.9 0.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.13 ESA05633.1 - 4e-05 23.3 0.0 0.24 11.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein NACHT PF05729.7 ESA05633.1 - 4.1e-05 23.2 0.0 0.13 11.9 0.0 3.6 4 0 0 4 4 4 1 NACHT domain AAA_24 PF13479.1 ESA05633.1 - 4.4e-05 23.1 0.0 0.26 10.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.8 ESA05633.1 - 5.8e-05 22.1 0.0 0.05 12.5 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF815) NB-ARC PF00931.17 ESA05633.1 - 6.1e-05 22.0 0.1 0.073 11.9 0.0 2.8 3 0 0 3 3 3 2 NB-ARC domain Viral_helicase1 PF01443.13 ESA05633.1 - 0.0001 21.9 0.0 0.0052 16.3 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 ESA05633.1 - 0.00023 20.4 0.2 0.64 9.2 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.4 ESA05633.1 - 0.00027 20.0 0.8 0.29 10.0 0.0 3.0 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.6 ESA05633.1 - 0.0003 20.4 0.0 0.93 9.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.1 ESA05633.1 - 0.00092 18.8 0.0 0.27 10.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 ESA05633.1 - 0.0022 17.7 0.2 1.3 8.6 0.0 3.5 3 0 0 3 3 3 1 NTPase SKI PF01202.17 ESA05633.1 - 0.004 17.0 0.3 1.8 8.4 0.0 2.8 3 0 0 3 3 2 1 Shikimate kinase Cytidylate_kin2 PF13189.1 ESA05633.1 - 0.0042 17.0 0.0 0.7 9.7 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family ATP-synt_ab PF00006.20 ESA05633.1 - 0.013 14.9 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_30 PF13604.1 ESA05633.1 - 0.022 14.3 0.0 7.1 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 ESA05633.1 - 0.025 13.4 0.0 1.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_10 PF12846.2 ESA05633.1 - 0.026 13.9 0.8 2.2 7.6 0.0 3.6 3 1 0 4 4 4 0 AAA-like domain AAA_23 PF13476.1 ESA05633.1 - 0.028 14.7 0.1 2.9 8.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.10 ESA05633.1 - 0.034 12.8 0.0 2.9 6.4 0.0 2.9 3 0 0 3 3 3 0 Rad17 cell cycle checkpoint protein CDC48_N PF02359.13 ESA05633.1 - 0.05 13.5 0.1 0.25 11.3 0.0 2.3 2 0 0 2 2 1 0 Cell division protein 48 (CDC48), N-terminal domain UPF0079 PF02367.12 ESA05633.1 - 0.054 13.1 0.1 4.3 6.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Zot PF05707.7 ESA05633.1 - 0.088 12.2 0.1 8.4 5.8 0.1 3.2 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) DEAD PF00270.24 ESA05633.1 - 0.11 11.9 0.1 44 3.5 0.0 3.4 3 1 1 4 4 3 0 DEAD/DEAH box helicase KAP_NTPase PF07693.9 ESA05633.1 - 0.18 10.7 0.0 6.6 5.6 0.0 2.6 2 2 0 2 2 2 0 KAP family P-loop domain PDH PF02153.12 ESA05634.1 - 3.4e-15 55.6 0.2 4.8e-15 55.1 0.2 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.12 ESA05634.1 - 1.1e-09 38.5 0.0 2.1e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 ESA05634.1 - 3.9e-08 33.3 0.0 6.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 ESA05634.1 - 0.00082 18.5 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 ESA05634.1 - 0.0028 17.7 0.0 0.0056 16.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 ESA05634.1 - 0.021 14.5 0.1 0.064 12.9 0.0 1.7 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 ESA05634.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Uma2 PF05685.7 ESA05636.1 - 0.00011 21.6 0.0 0.00018 20.8 0.0 1.4 1 0 0 1 1 1 1 Putative restriction endonuclease RabGAP-TBC PF00566.13 ESA05638.1 - 0.031 13.7 0.1 0.034 13.6 0.0 1.0 1 0 0 1 1 1 0 Rab-GTPase-TBC domain GBP_repeat PF02526.9 ESA05638.1 - 0.091 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycophorin-binding protein Sel1 PF08238.7 ESA05639.1 - 3.6e-08 33.7 0.3 2.9e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Sel1 repeat TPR_12 PF13424.1 ESA05639.1 - 0.058 13.3 0.1 0.1 12.5 0.0 1.4 1 1 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA05640.1 - 2.1e-36 125.4 0.6 2.4e-36 125.2 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05640.1 - 1.6e-34 119.2 0.1 1.8e-34 118.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA05640.1 - 0.00051 19.3 0.8 0.00097 18.4 0.6 1.4 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA05640.1 - 0.00074 18.9 0.0 0.0018 17.6 0.0 1.6 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA05640.1 - 0.0031 17.2 0.1 0.029 14.1 0.2 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA05640.1 - 0.011 14.8 0.2 0.023 13.7 0.1 1.6 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA05640.1 - 0.092 12.3 1.5 0.13 11.7 1.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Glyco_hydro_52 PF03512.8 ESA05642.1 - 0.029 12.9 0.1 0.034 12.7 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 MacB_PCD PF12704.2 ESA05645.1 - 0.11 12.0 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 MacB-like periplasmic core domain DUF4258 PF14076.1 ESA05645.1 - 0.34 10.9 2.2 19 5.3 1.5 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4258) F-box-like PF12937.2 ESA05646.1 - 1.4e-06 27.9 0.1 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA05646.1 - 0.00079 19.0 0.1 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain Cyclin_N PF00134.18 ESA05647.1 - 8.7e-05 22.0 0.0 0.09 12.3 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin PF08613.6 ESA05647.1 - 0.00064 20.1 0.1 0.66 10.3 0.0 2.6 3 0 0 3 3 3 2 Cyclin BTB_2 PF02214.17 ESA05648.1 - 7e-17 61.4 0.6 1.7e-15 56.9 0.1 2.4 1 1 1 2 2 2 1 BTB/POZ domain F-112 PF09645.5 ESA05649.1 - 0.039 13.8 2.2 0.049 13.5 1.5 1.3 1 1 0 1 1 1 0 F-112 protein MIR PF02815.14 ESA05650.1 - 0.00015 21.3 0.4 0.038 13.5 0.0 2.1 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA05650.1 - 0.031 13.3 0.1 0.18 10.7 0.0 1.9 1 1 1 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Strabismus PF06638.6 ESA05652.1 - 0.12 10.6 0.0 0.14 10.4 0.0 1.0 1 0 0 1 1 1 0 Strabismus protein DUF1413 PF07205.6 ESA05653.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) Fungal_trans_2 PF11951.3 ESA05654.1 - 0.26 9.8 7.8 0.015 13.9 1.9 1.4 2 0 0 2 2 2 0 Fungal specific transcription factor domain MIF4G_like_2 PF09090.6 ESA05654.1 - 0.39 9.9 19.5 0.29 10.3 2.5 2.2 1 1 1 2 2 2 0 MIF4G like Hom_end_hint PF05203.11 ESA05654.1 - 0.44 10.2 8.1 0.53 9.9 5.6 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint SpecificRecomb PF10136.4 ESA05654.1 - 0.51 8.3 2.6 0.71 7.8 1.8 1.2 1 0 0 1 1 1 0 Site-specific recombinase DUF3450 PF11932.3 ESA05654.1 - 0.55 9.4 23.2 0.044 13.0 11.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4559 PF15112.1 ESA05654.1 - 0.63 9.1 24.6 0.076 12.1 12.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) AAA_13 PF13166.1 ESA05654.1 - 0.82 8.0 32.8 0.13 10.6 19.2 2.0 1 1 0 1 1 1 0 AAA domain CRISPR_Cas2 PF09827.4 ESA05654.1 - 1.2 9.2 0.0 1.2 9.2 0.0 3.1 3 1 0 3 3 3 0 CRISPR associated protein Cas2 Prominin PF05478.6 ESA05654.1 - 1.4 6.3 20.9 0.22 9.0 9.8 2.1 1 1 1 2 2 2 0 Prominin DUF4201 PF13870.1 ESA05654.1 - 2 7.8 34.9 1.3 8.3 19.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) GlnE PF03710.10 ESA05654.1 - 2 7.6 6.5 0.76 8.9 1.7 2.0 2 0 0 2 2 2 0 Glutamate-ammonia ligase adenylyltransferase Reo_sigmaC PF04582.7 ESA05654.1 - 2.6 7.1 7.6 0.7 9.0 1.9 2.1 2 1 0 2 2 2 0 Reovirus sigma C capsid protein HrpB7 PF09486.5 ESA05654.1 - 2.7 7.9 10.6 4.9 7.0 1.9 3.0 1 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Lectin_N PF03954.9 ESA05654.1 - 3.3 7.0 14.0 3 7.2 4.9 2.6 1 1 0 2 2 2 0 Hepatic lectin, N-terminal domain ApoO PF09769.4 ESA05654.1 - 5 6.8 8.3 34 4.1 3.1 2.9 2 1 0 2 2 2 0 Apolipoprotein O TMF_DNA_bd PF12329.3 ESA05654.1 - 5.3 6.9 51.3 0.37 10.6 2.4 3.7 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Tropomyosin PF00261.15 ESA05654.1 - 6.6 5.7 34.8 9.5 5.2 19.1 2.9 2 1 0 2 2 2 0 Tropomyosin Fib_alpha PF08702.5 ESA05654.1 - 7.5 6.6 32.9 2.8 8.0 12.5 3.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Mod_r PF07200.8 ESA05654.1 - 7.9 6.3 33.3 13 5.7 1.2 3.6 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Atx10homo_assoc PF09759.4 ESA05654.1 - 8.3 6.2 14.4 1.6 8.4 1.0 2.9 1 1 2 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Claudin_2 PF13903.1 ESA05655.1 - 0.038 13.6 4.2 0.14 11.8 2.9 1.9 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2985 PF11204.3 ESA05655.1 - 0.31 10.8 4.7 5 6.9 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2985) YwiC PF14256.1 ESA05655.1 - 1.5 8.9 6.2 2.4 8.2 3.5 1.9 1 1 1 2 2 2 0 YwiC-like protein Nop53 PF07767.6 ESA05657.1 - 1.8e-52 178.6 27.4 5.3e-51 173.8 18.3 2.2 1 1 1 2 2 2 2 Nop53 (60S ribosomal biogenesis) Init_tRNA_PT PF04179.7 ESA05657.1 - 0.049 12.4 11.8 0.071 11.9 8.2 1.2 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase GET2 PF08690.5 ESA05657.1 - 0.21 10.7 8.6 0.3 10.3 5.9 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF740 PF05340.7 ESA05657.1 - 5.4 5.2 19.0 7.6 4.7 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) NAD_kinase PF01513.16 ESA05658.1 - 2.1e-57 194.1 0.0 2.8e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase HMA PF00403.21 ESA05659.1 - 6e-08 32.7 0.0 8.7e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain AAA_PrkA PF08298.6 ESA05659.1 - 0.026 13.2 0.0 0.026 13.2 0.0 1.0 1 0 0 1 1 1 0 PrkA AAA domain Phage_hub_GP28 PF11110.3 ESA05663.1 - 0.047 13.3 0.3 0.088 12.4 0.1 1.5 1 1 0 1 1 1 0 Baseplate hub distal subunit NPL4 PF05021.10 ESA05664.1 - 0.061 12.4 0.0 0.07 12.2 0.0 1.0 1 0 0 1 1 1 0 NPL4 family TLD PF07534.11 ESA05665.1 - 9.6e-14 51.5 2.3 9.6e-14 51.5 1.6 2.1 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA05665.1 - 2.2e-08 34.0 0.2 9e-07 28.8 0.0 2.6 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA05665.1 - 3.4e-06 26.8 1.4 1.5e-05 24.8 0.1 2.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch Cyclin_N PF00134.18 ESA05666.1 - 2.2e-05 23.9 0.0 0.0028 17.2 0.0 2.1 1 1 1 2 2 2 2 Cyclin, N-terminal domain Asparaginase PF00710.15 ESA05667.1 - 1.6e-72 244.0 0.0 2.6e-72 243.3 0.0 1.3 1 0 0 1 1 1 1 Asparaginase Ank_2 PF12796.2 ESA05667.1 - 7.5e-30 103.1 0.8 2.2e-17 63.1 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA05667.1 - 2.5e-26 91.5 3.4 1.6e-10 41.2 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 ESA05667.1 - 9.8e-25 85.0 6.0 6.6e-12 44.6 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 ESA05667.1 - 2.2e-20 70.7 2.7 6.8e-06 25.8 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 ESA05667.1 - 2.3e-19 68.9 0.1 5.2e-09 36.0 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF3289 PF11692.3 ESA05667.1 - 0.047 12.9 0.0 4.2 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3289) Y_phosphatase2 PF03162.8 ESA05667.1 - 0.1 11.9 1.5 0.25 10.6 0.0 2.2 3 0 0 3 3 3 0 Tyrosine phosphatase family Pkinase PF00069.20 ESA05670.1 - 2.7e-42 144.7 0.1 4.4e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05670.1 - 7e-35 120.3 0.0 1.2e-34 119.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA05670.1 - 0.00056 19.3 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA05670.1 - 0.0017 18.1 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA05670.1 - 0.036 13.2 0.3 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA05670.1 - 0.075 12.0 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NUC129 PF08157.6 ESA05671.1 - 0.066 13.1 0.1 1 9.3 0.0 2.4 2 0 0 2 2 2 0 NUC129 domain Cu-oxidase_2 PF07731.9 ESA05672.1 - 6.3e-19 67.8 0.5 9e-19 67.3 0.3 1.1 1 0 0 1 1 1 1 Multicopper oxidase Pkinase_Tyr PF07714.12 ESA05673.1 - 1.1e-32 113.0 0.3 1.3e-32 112.9 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05673.1 - 2.1e-31 109.0 1.7 2.4e-31 108.8 1.2 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA05673.1 - 0.00012 21.9 0.1 0.00016 21.4 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA05673.1 - 0.0061 15.6 0.1 0.0088 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA05673.1 - 0.011 15.0 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA05673.1 - 0.016 14.5 0.9 0.03 13.6 0.6 1.6 1 1 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESA05673.1 - 0.22 11.0 2.8 0.42 10.1 1.9 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase NPH3 PF03000.9 ESA05675.1 - 0.05 13.1 0.4 0.086 12.3 0.2 1.3 1 0 0 1 1 1 0 NPH3 family AAA_13 PF13166.1 ESA05676.1 - 0.0017 16.9 38.8 0.0017 16.9 26.9 3.4 2 1 1 3 3 3 2 AAA domain zf-C2H2 PF00096.21 ESA05677.1 - 0.035 14.4 0.8 0.13 12.7 0.6 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type BRAP2 PF07576.7 ESA05678.1 - 0.061 12.9 6.2 0.27 10.8 0.5 2.9 2 0 0 2 2 2 0 BRCA1-associated protein 2 Svf1 PF08622.5 ESA05679.1 - 5e-92 308.3 4.0 5.6e-92 308.1 2.8 1.0 1 0 0 1 1 1 1 Svf1-like HAD_2 PF13419.1 ESA05681.1 - 1.1e-18 68.0 0.0 1.6e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA05681.1 - 6.3e-07 29.0 0.0 9.6e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESA05681.1 - 8.6e-05 23.0 0.0 0.00029 21.3 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Surf_Ag_VNR PF07244.10 ESA05681.1 - 0.17 12.3 2.5 0.31 11.5 0.1 2.6 3 0 0 3 3 3 0 Surface antigen variable number repeat SAC3 PF12209.3 ESA05681.1 - 0.65 10.1 4.7 18 5.5 0.1 3.2 3 1 0 3 3 3 0 Leucine permease transcriptional regulator helical domain PCMT PF01135.14 ESA05682.1 - 1.3e-78 263.3 0.0 1.6e-78 263.0 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 ESA05682.1 - 5.6e-13 48.7 0.0 7.9e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA05682.1 - 6.5e-11 42.8 0.0 9.3e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA05682.1 - 3.2e-07 30.2 0.0 4.6e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA05682.1 - 3.3e-07 30.3 0.0 7.2e-07 29.2 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA05682.1 - 1.8e-06 28.3 0.0 4e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 ESA05682.1 - 1.8e-06 27.1 0.0 2.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Ubie_methyltran PF01209.13 ESA05682.1 - 1.9e-06 27.1 0.0 2.5e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA05682.1 - 7.4e-06 26.2 0.0 1.7e-05 25.1 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 ESA05682.1 - 1.1e-05 25.1 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA05682.1 - 1.1e-05 24.8 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.6 ESA05682.1 - 1.6e-05 23.7 0.0 2.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.8 ESA05682.1 - 1.9e-05 23.9 0.0 2.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.12 ESA05682.1 - 4e-05 22.7 0.0 6.2e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_4 PF02390.12 ESA05682.1 - 5.1e-05 22.4 0.0 9.3e-05 21.5 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 ESA05682.1 - 0.00053 19.1 0.0 0.00088 18.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Fibrillarin PF01269.12 ESA05682.1 - 0.00068 18.6 0.0 0.0012 17.8 0.0 1.5 1 1 0 1 1 1 1 Fibrillarin MetW PF07021.7 ESA05682.1 - 0.0025 17.2 0.0 0.004 16.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW GCD14 PF08704.5 ESA05682.1 - 0.0033 16.9 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.14 ESA05682.1 - 0.0034 17.3 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_12 PF08242.7 ESA05682.1 - 0.0096 16.3 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESA05682.1 - 0.026 15.3 0.0 0.069 13.9 0.0 1.7 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 ESA05682.1 - 0.033 13.6 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase F-box-like PF12937.2 ESA05683.1 - 3.7e-06 26.5 0.9 5.4e-06 26.0 0.1 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA05683.1 - 0.29 10.8 4.5 1.3 8.7 0.4 2.6 2 0 0 2 2 2 0 F-box domain DNA_gyraseB PF00204.20 ESA05685.1 - 0.098 11.8 0.3 0.11 11.6 0.2 1.1 1 0 0 1 1 1 0 DNA gyrase B zf-BED PF02892.10 ESA05685.1 - 0.1 12.3 0.3 0.15 11.8 0.2 1.3 1 0 0 1 1 1 0 BED zinc finger TLD PF07534.11 ESA05686.1 - 4.2e-12 46.2 0.2 5.9e-12 45.7 0.1 1.3 1 0 0 1 1 1 1 TLD AAA PF00004.24 ESA05687.1 - 2e-19 70.1 0.0 2.9e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA05687.1 - 1.3e-05 26.0 0.1 2.8e-05 24.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESA05687.1 - 3.8e-05 23.7 0.2 0.00014 21.8 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESA05687.1 - 4.2e-05 23.7 0.5 0.0015 18.6 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA05687.1 - 0.00071 19.2 0.1 0.0019 17.9 0.0 1.7 2 0 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 ESA05687.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.6 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESA05687.1 - 0.0012 19.1 0.0 0.0024 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESA05687.1 - 0.0036 16.3 0.0 0.0052 15.8 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ESA05687.1 - 0.0053 16.6 0.0 0.019 14.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zot PF05707.7 ESA05687.1 - 0.0064 15.9 0.0 0.98 8.8 0.0 2.3 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) Vps36_ESCRT-II PF11605.3 ESA05687.1 - 0.0088 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Mg_chelatase PF01078.16 ESA05687.1 - 0.011 14.8 0.1 0.021 14.0 0.1 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESA05687.1 - 0.018 13.7 0.0 0.025 13.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus IstB_IS21 PF01695.12 ESA05687.1 - 0.026 13.9 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.1 ESA05687.1 - 0.03 14.2 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESA05687.1 - 0.035 14.0 0.0 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 ESA05687.1 - 0.035 13.6 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESA05687.1 - 0.036 13.7 0.1 1.4 8.5 0.0 2.2 1 1 1 2 2 2 0 NTPase KaiC PF06745.8 ESA05687.1 - 0.1 11.6 1.0 6.6 5.7 0.1 2.1 1 1 1 2 2 2 0 KaiC AAA_33 PF13671.1 ESA05687.1 - 0.12 12.3 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 ESA05687.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 RNA_helicase PF00910.17 ESA05687.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.1 ESA05687.1 - 0.15 11.6 0.0 0.27 10.7 0.0 1.4 1 1 0 1 1 1 0 AAA domain ChW PF07538.6 ESA05690.1 - 0.14 11.6 0.6 0.32 10.5 0.4 1.6 1 0 0 1 1 1 0 Clostridial hydrophobic W MFS_2 PF13347.1 ESA05690.1 - 0.76 8.1 6.9 1.5 7.1 4.8 1.5 1 1 0 1 1 1 0 MFS/sugar transport protein MVL PF12151.3 ESA05690.1 - 2.8 7.6 7.6 9.5 5.9 0.4 2.7 3 0 0 3 3 3 0 Mannan-binding protein LRR_4 PF12799.2 ESA05691.1 - 1.4e-21 75.6 13.3 1.6e-06 27.5 1.1 3.6 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA05691.1 - 3.7e-15 55.4 8.5 5.5e-07 29.2 0.3 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 ESA05691.1 - 1.3e-14 51.9 2.8 0.0071 16.2 0.0 5.0 5 0 0 5 5 5 4 Leucine Rich Repeat LRR_7 PF13504.1 ESA05691.1 - 1.9e-08 33.1 12.0 0.048 13.8 0.1 5.4 6 0 0 6 6 6 3 Leucine rich repeat LRR_6 PF13516.1 ESA05691.1 - 2.9e-07 29.8 3.8 0.06 13.4 0.0 4.0 3 1 1 4 4 4 3 Leucine Rich repeat LRR_9 PF14580.1 ESA05691.1 - 0.017 14.6 0.3 0.02 14.4 0.2 1.1 1 0 0 1 1 1 0 Leucine-rich repeat LRR_3 PF07725.7 ESA05691.1 - 0.037 13.7 6.1 7.6 6.5 0.1 3.9 5 0 0 5 5 5 0 Leucine Rich Repeat Glyoxal_oxid_N PF07250.6 ESA05692.1 - 1.6e-25 89.6 0.1 9.1e-25 87.1 0.0 2.0 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ESA05692.1 - 1.2e-13 50.9 0.1 3.3e-13 49.5 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.1 ESA05692.1 - 0.00026 21.0 3.7 1.2 9.4 0.0 4.6 3 1 1 4 4 4 1 Kelch motif Kelch_1 PF01344.20 ESA05692.1 - 0.0011 18.4 1.4 0.025 14.1 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESA05692.1 - 0.0025 17.5 0.1 2.4 7.9 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA05692.1 - 0.017 15.0 0.5 17 5.5 0.0 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.10 ESA05692.1 - 0.052 13.3 0.1 6.3 6.7 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Pkinase_Tyr PF07714.12 ESA05693.1 - 3.3e-26 91.9 0.1 6.6e-23 81.1 0.0 3.9 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05693.1 - 4.4e-19 68.6 4.9 4.7e-19 68.5 1.6 2.4 2 1 0 2 2 2 1 Protein kinase domain TraT PF05818.7 ESA05693.1 - 0.0004 19.8 1.2 2.5 7.4 0.0 3.9 4 0 0 4 4 4 2 Enterobacterial TraT complement resistance protein RIO1 PF01163.17 ESA05693.1 - 0.0045 16.3 0.5 0.011 15.1 0.3 1.6 1 0 0 1 1 1 1 RIO1 family Fer4_7 PF12838.2 ESA05693.1 - 0.0085 16.4 8.8 12 6.4 1.8 4.3 3 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESA05693.1 - 0.011 15.7 8.9 6.5 6.8 0.0 4.2 3 1 1 4 4 4 0 4Fe-4S dicluster domain APH PF01636.18 ESA05693.1 - 0.17 11.6 0.1 0.3 10.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fer4_9 PF13187.1 ESA05693.1 - 0.22 11.7 14.9 13 6.0 0.1 4.5 4 0 0 4 4 4 0 4Fe-4S dicluster domain DUF4373 PF14297.1 ESA05693.1 - 1.6 9.0 6.1 3.8 7.8 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4373) QRPTase_C PF01729.14 ESA05694.1 - 7.1e-57 191.6 0.0 8.9e-57 191.2 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 ESA05694.1 - 5.4e-24 83.8 0.0 1.2e-23 82.6 0.0 1.6 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Pkinase_Tyr PF07714.12 ESA05697.1 - 1.1e-13 50.8 0.0 1.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05697.1 - 1.1e-09 37.8 0.0 1.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Glyco_hydro_63 PF03200.11 ESA05698.1 - 9.9e-78 261.8 7.5 2.3e-76 257.3 5.2 2.0 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Bac_rhamnosid PF05592.6 ESA05698.1 - 0.0012 17.1 0.0 0.0016 16.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase Trehalase PF01204.13 ESA05698.1 - 0.011 14.4 0.1 0.015 13.9 0.1 1.2 1 0 0 1 1 1 0 Trehalase Pkinase_Tyr PF07714.12 ESA05699.1 - 2.7e-32 111.8 0.0 5.7e-30 104.2 0.1 4.2 6 0 0 6 6 6 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05699.1 - 6.2e-26 91.1 1.5 6.2e-26 91.1 1.1 3.4 3 0 0 3 3 3 1 Protein kinase domain TraT PF05818.7 ESA05699.1 - 6.9e-07 28.9 14.5 0.24 10.7 0.1 7.3 8 0 0 8 8 8 4 Enterobacterial TraT complement resistance protein DUF3488 PF11992.3 ESA05699.1 - 0.0083 14.7 5.6 4.8 5.7 0.1 5.3 6 0 0 6 6 6 1 Domain of unknown function (DUF3488) DUF2373 PF10180.4 ESA05699.1 - 0.016 14.7 0.1 0.016 14.7 0.0 5.6 6 0 0 6 6 6 0 Uncharacterised conserved protein (DUF2373) DUF4134 PF13572.1 ESA05699.1 - 3.5 7.7 11.3 1.2e+02 2.8 0.0 6.5 8 0 0 8 8 8 0 Domain of unknown function (DUF4134) mRNA_triPase PF02940.10 ESA05700.1 - 1.6e-48 165.3 3.0 2.2e-48 164.8 2.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain zf-AD PF07776.10 ESA05702.1 - 0.02 14.8 0.1 0.049 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Pkinase_Tyr PF07714.12 ESA05704.1 - 1.7e-06 27.3 0.0 2.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase K-box PF01486.12 ESA05705.1 - 0.065 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 K-box region Toxin_21 PF08091.6 ESA05706.1 - 0.026 14.2 4.6 0.026 14.2 3.2 2.3 2 0 0 2 2 2 0 Spider insecticidal peptide DUF1869 PF08956.5 ESA05707.1 - 0.034 13.7 0.2 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) DivIVA PF05103.8 ESA05708.1 - 0.0035 17.4 2.0 0.0059 16.6 1.4 1.4 1 0 0 1 1 1 1 DivIVA protein RasGAP_C PF03836.10 ESA05708.1 - 0.0038 16.9 1.3 0.005 16.5 0.9 1.2 1 0 0 1 1 1 1 RasGAP C-terminus Seryl_tRNA_N PF02403.17 ESA05708.1 - 0.0057 16.6 0.1 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.10 ESA05708.1 - 0.0064 15.9 2.8 0.012 15.0 1.9 1.5 1 0 0 1 1 1 1 Septum formation initiator DUF904 PF06005.7 ESA05708.1 - 0.0095 16.2 3.7 0.021 15.0 2.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF904) Syntaxin-6_N PF09177.6 ESA05708.1 - 0.011 16.1 1.7 0.025 14.9 1.2 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Utp12 PF04003.7 ESA05708.1 - 0.024 14.5 0.9 0.33 10.8 0.6 2.4 2 1 0 2 2 2 0 Dip2/Utp12 Family IncA PF04156.9 ESA05708.1 - 0.03 13.9 0.7 0.046 13.3 0.5 1.3 1 0 0 1 1 1 0 IncA protein Syntaxin PF00804.20 ESA05708.1 - 0.044 13.9 4.2 0.26 11.4 2.9 2.1 1 1 0 1 1 1 0 Syntaxin DUF972 PF06156.8 ESA05708.1 - 0.055 13.8 1.7 0.097 13.0 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) RPW8 PF05659.6 ESA05708.1 - 0.083 12.4 0.5 0.13 11.7 0.3 1.2 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2730 PF10805.3 ESA05708.1 - 0.086 12.5 0.3 0.18 11.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) AAA_23 PF13476.1 ESA05708.1 - 0.11 12.8 2.9 0.12 12.6 2.0 1.2 1 1 0 1 1 1 0 AAA domain WXG100 PF06013.7 ESA05708.1 - 0.11 12.4 0.4 0.42 10.6 0.4 1.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG IucA_IucC PF04183.7 ESA05709.1 - 4.4e-30 104.7 0.0 7.7e-30 103.9 0.0 1.4 1 1 0 1 1 1 1 IucA / IucC family FhuF PF06276.7 ESA05709.1 - 2.8e-09 37.1 0.1 3.9e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter DUF226 PF02890.9 ESA05710.1 - 0.0051 16.5 0.3 0.0079 15.9 0.2 1.4 1 0 0 1 1 1 1 Borrelia family of unknown function DUF226 MIR PF02815.14 ESA05710.1 - 0.0059 16.1 0.9 0.06 12.8 0.6 2.2 1 1 0 1 1 1 1 MIR domain BTD PF09270.5 ESA05710.1 - 0.046 13.4 0.6 1.1 9.0 0.2 2.1 1 1 1 2 2 2 0 Beta-trefoil DNA-binding domain HNOB PF07700.10 ESA05710.1 - 0.46 9.9 2.5 2.6 7.5 0.0 2.7 2 1 1 3 3 3 0 Heme NO binding DUF4318 PF14201.1 ESA05711.1 - 0.021 14.6 0.1 0.039 13.7 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4318) tRNA_lig_CPD PF08302.6 ESA05712.1 - 0.1 11.7 0.0 0.11 11.6 0.0 1.0 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain Herpes_UL69 PF05459.7 ESA05712.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family RNA_bind_2 PF10133.4 ESA05714.1 - 0.2 11.7 0.7 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 Predicted RNA-binding protein Hint PF01079.15 ESA05715.1 - 1.1e-19 70.4 0.0 1.7e-19 69.8 0.0 1.3 1 1 0 1 1 1 1 Hint module DUF2160 PF09928.4 ESA05716.1 - 0.021 14.9 0.1 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2160) DUF1443 PF07280.6 ESA05716.1 - 0.29 10.7 4.0 0.41 10.2 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1443) DUF3961 PF13106.1 ESA05716.1 - 4.5 6.9 6.3 7.8 6.1 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) Glyco_hydro_101 PF12905.2 ESA05717.1 - 0.029 12.9 0.0 0.043 12.4 0.0 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase FAM196 PF15265.1 ESA05721.1 - 0.011 14.9 7.1 0.013 14.8 4.9 1.1 1 0 0 1 1 1 0 FAM196 family TFIIA PF03153.8 ESA05721.1 - 0.2 11.4 13.4 0.22 11.3 9.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.7 ESA05721.1 - 0.38 10.2 8.2 0.87 9.0 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Fungal_trans PF04082.13 ESA05722.1 - 1.4e-15 56.8 0.1 1.7e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2974 PF11187.3 ESA05723.1 - 0.015 14.6 0.4 0.02 14.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Pkinase_Tyr PF07714.12 ESA05723.1 - 0.042 12.9 0.1 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Chordopox_A20R PF05941.8 ESA05726.1 - 0.044 12.5 0.0 0.044 12.5 0.0 1.1 1 0 0 1 1 1 0 Chordopoxvirus A20R protein LRR_6 PF13516.1 ESA05728.1 - 0.00011 21.9 10.4 6.3 7.1 0.0 6.4 7 0 0 7 7 7 2 Leucine Rich repeat GAT PF03127.9 ESA05728.1 - 0.0014 18.5 0.3 2.6 8.0 0.0 3.4 3 0 0 3 3 3 2 GAT domain IL3 PF02059.10 ESA05728.1 - 0.0036 17.2 0.5 0.052 13.5 0.0 2.5 2 0 0 2 2 2 1 Interleukin-3 F-box-like PF12937.2 ESA05728.1 - 0.0047 16.6 0.1 0.016 14.9 0.1 2.0 1 0 0 1 1 1 1 F-box-like LRR_7 PF13504.1 ESA05728.1 - 0.0049 16.8 5.9 1.5 9.3 0.0 5.1 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 ESA05728.1 - 0.0075 16.1 6.5 6.9 7.1 0.0 5.5 3 2 1 4 4 4 2 Leucine Rich Repeat LRR_4 PF12799.2 ESA05728.1 - 0.041 13.5 8.0 6.6 6.4 0.1 5.5 4 2 2 6 6 6 0 Leucine Rich repeats (2 copies) DUF4441 PF14536.1 ESA05728.1 - 0.18 11.8 2.9 0.5 10.3 0.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4441) F-box PF00646.28 ESA05728.1 - 0.25 11.0 4.6 1.6 8.4 0.1 2.9 2 0 0 2 2 2 0 F-box domain Pribosyltran PF00156.22 ESA05729.1 - 7.2e-11 41.9 0.1 1.2e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.1 ESA05729.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain DUF3452 PF11934.3 ESA05730.1 - 0.01 15.1 2.1 0.018 14.3 1.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) DUF2450 PF10475.4 ESA05732.1 - 0.0078 15.1 2.7 0.014 14.2 1.9 1.3 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Med4 PF10018.4 ESA05732.1 - 0.01 15.2 1.0 0.021 14.2 0.7 1.5 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Spectrin PF00435.16 ESA05732.1 - 0.022 15.0 0.9 0.047 13.9 0.6 1.6 1 0 0 1 1 1 0 Spectrin repeat Laminin_II PF06009.7 ESA05732.1 - 0.023 14.4 3.8 0.052 13.2 2.6 1.6 1 0 0 1 1 1 0 Laminin Domain II Arch_fla_DE PF04659.8 ESA05732.1 - 0.072 12.8 3.6 0.32 10.8 0.1 3.0 1 1 3 4 4 4 0 Archaeal flagella protein DUF1664 PF07889.7 ESA05732.1 - 0.075 12.8 1.2 0.16 11.7 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sel1 PF08238.7 ESA05733.1 - 8.4e-23 80.2 8.7 1.1e-11 45.0 0.6 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_7 PF13176.1 ESA05733.1 - 0.00018 21.0 2.8 0.36 10.7 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA05733.1 - 0.00069 19.5 4.7 0.027 14.3 1.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA05733.1 - 0.005 17.3 0.1 1.8 9.3 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA05733.1 - 0.0089 15.6 9.4 0.052 13.2 4.0 2.5 1 1 1 2 2 2 2 TPR repeat SNAP PF14938.1 ESA05733.1 - 0.041 13.0 2.7 0.15 11.1 1.9 1.7 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_6 PF13174.1 ESA05733.1 - 0.062 13.7 4.8 1.5 9.4 0.2 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA05733.1 - 0.074 12.9 6.0 0.7 9.8 0.3 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.1 ESA05733.1 - 0.075 13.3 1.2 4.7 7.6 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA05733.1 - 0.12 12.6 6.6 2.7 8.4 0.1 3.5 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA05733.1 - 0.3 11.0 12.9 3.1 7.9 0.1 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA05733.1 - 0.45 10.2 17.8 0.74 9.5 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA05733.1 - 6 6.8 13.1 3 7.8 0.3 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA05734.1 - 0.00032 19.8 0.1 0.00044 19.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05734.1 - 0.067 12.3 0.1 0.14 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain DUF4110 PF13422.1 ESA05735.1 - 0.02 14.7 1.6 0.038 13.8 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) FlbT PF07378.6 ESA05735.1 - 0.03 14.1 1.6 0.056 13.3 1.1 1.4 1 0 0 1 1 1 0 Flagellar protein FlbT SurA_N PF09312.6 ESA05735.1 - 0.036 13.9 2.4 0.057 13.2 1.7 1.3 1 0 0 1 1 1 0 SurA N-terminal domain DUF4497 PF14924.1 ESA05735.1 - 0.08 13.2 0.9 0.13 12.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) PRP1_N PF06424.7 ESA05735.1 - 3.2 8.0 7.2 0.89 9.8 2.6 1.7 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal F-box-like PF12937.2 ESA05736.1 - 0.0015 18.2 1.3 0.003 17.2 0.2 2.1 2 0 0 2 2 2 1 F-box-like Fungal_trans PF04082.13 ESA05737.1 - 2.9e-19 68.9 0.0 3.3e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box-like PF12937.2 ESA05738.1 - 0.0025 17.5 0.5 0.0069 16.0 0.3 1.7 1 0 0 1 1 1 1 F-box-like DUF3677 PF12432.3 ESA05738.1 - 0.14 12.6 2.2 0.31 11.5 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3677) p450 PF00067.17 ESA05741.1 - 3.8e-20 71.8 0.0 4.2e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB PF00651.26 ESA05742.1 - 1.7e-10 40.8 1.1 8.6e-10 38.5 0.8 2.1 1 1 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA05742.1 - 0.14 12.2 0.6 0.66 10.1 0.2 2.3 2 1 0 2 2 2 0 Skp1 family, tetramerisation domain Pkinase_Tyr PF07714.12 ESA05743.1 - 6.4e-11 41.8 0.2 7.3e-11 41.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05743.1 - 1.5e-09 37.3 0.8 1.6e-09 37.3 0.6 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF2324 PF10086.4 ESA05744.1 - 0.001 18.3 0.1 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Putative membrane peptidase family (DUF2324) Pkinase PF00069.20 ESA05745.1 - 5.1e-15 55.3 0.7 1.1e-08 34.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05745.1 - 8.3e-11 41.4 0.3 3.3e-08 32.9 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase AA_permease_2 PF13520.1 ESA05746.1 - 2e-53 181.4 42.4 2.6e-53 181.1 29.4 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA05746.1 - 1.6e-11 43.2 31.3 1.6e-11 43.2 21.7 1.4 2 0 0 2 2 2 1 Amino acid permease DUF4381 PF14316.1 ESA05746.1 - 0.037 14.1 0.8 0.037 14.1 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DUF1363 PF07101.6 ESA05747.1 - 0.022 14.8 0.6 0.031 14.3 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1363) PLATZ PF04640.9 ESA05747.1 - 0.053 13.7 0.1 0.13 12.4 0.1 1.6 2 0 0 2 2 2 0 PLATZ transcription factor ABC_tran_2 PF12848.2 ESA05747.1 - 0.12 12.2 0.4 0.26 11.1 0.3 1.5 1 0 0 1 1 1 0 ABC transporter Pkinase PF00069.20 ESA05748.1 - 7.8e-69 231.7 0.0 9.1e-69 231.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05748.1 - 4.8e-50 170.0 0.0 6.2e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA05748.1 - 2.5e-07 29.9 0.0 4.7e-07 29.0 0.0 1.4 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA05748.1 - 0.00031 20.1 0.0 0.00084 18.7 0.0 1.8 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.9 ESA05748.1 - 0.036 13.1 0.0 0.06 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Euplotes_phero PF05842.6 ESA05749.1 - 0.1 12.9 1.3 0.11 12.8 0.9 1.1 1 0 0 1 1 1 0 Euplotes octocarinatus mating pheromone protein Thioredoxin_9 PF14595.1 ESA05749.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Synaptonemal_3 PF15191.1 ESA05749.1 - 0.27 10.9 1.8 8.2 6.2 0.1 2.1 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 CHASE PF03924.8 ESA05750.1 - 1.2e-19 70.3 0.0 1.7e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 CHASE domain PAS PF00989.19 ESA05750.1 - 7.2e-07 28.9 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESA05750.1 - 7.8e-07 29.4 0.0 2.2e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.1 ESA05750.1 - 0.00062 19.5 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain DEAD PF00270.24 ESA05752.1 - 4.1e-17 62.2 0.0 1.3e-16 60.5 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA05752.1 - 1.2e-16 60.3 0.0 4e-16 58.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA05752.1 - 0.00036 20.3 0.0 0.00036 20.3 0.0 3.1 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DUF2620 PF10941.3 ESA05752.1 - 0.074 13.0 0.2 0.44 10.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF2620 Vpu PF00558.14 ESA05753.1 - 2.4 7.7 5.7 1.3 8.5 0.2 2.3 2 0 0 2 2 2 0 Vpu protein Ribonuc_L-PSP PF01042.16 ESA05754.1 - 1.5e-44 150.6 0.1 1.7e-44 150.4 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Rab3-GTPase_cat PF13890.1 ESA05754.1 - 0.036 13.4 0.0 0.042 13.2 0.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit Septin PF00735.13 ESA05755.1 - 1.1e-112 375.6 0.7 1.4e-112 375.2 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 ESA05755.1 - 3.8e-05 23.6 0.0 0.00011 22.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA05755.1 - 0.0021 17.8 4.6 0.38 10.5 0.1 2.9 2 1 0 3 3 3 2 Dynamin family AIG1 PF04548.11 ESA05755.1 - 0.0024 17.0 0.0 0.0048 16.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 ESA05755.1 - 0.006 16.0 0.7 0.18 11.2 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESA05755.1 - 0.0064 15.6 0.3 0.028 13.5 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 ESA05755.1 - 0.019 15.4 0.1 0.052 14.0 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein DUF3653 PF12375.3 ESA05755.1 - 0.027 14.6 1.9 0.99 9.6 0.7 2.5 2 0 0 2 2 2 0 Phage protein FtsK_SpoIIIE PF01580.13 ESA05755.1 - 0.11 11.9 0.2 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Gasdermin PF04598.7 ESA05755.1 - 0.34 9.5 7.2 0.77 8.4 5.0 1.5 1 1 1 2 2 2 0 Gasdermin family AAA_17 PF13207.1 ESA05755.1 - 3.7 8.3 5.5 23 5.8 3.8 2.6 1 1 0 1 1 1 0 AAA domain Kelch_5 PF13854.1 ESA05758.1 - 8.9e-22 76.6 15.1 2.5e-06 27.2 0.0 5.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA05758.1 - 1.1e-21 76.3 4.4 0.00042 20.0 0.2 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA05758.1 - 3.5e-19 68.0 13.3 8.5e-05 22.5 0.2 5.6 3 1 2 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA05758.1 - 2.2e-16 59.1 14.6 9.6e-06 25.0 0.5 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA05758.1 - 9e-16 57.5 3.9 4e-05 23.6 0.0 5.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA05758.1 - 9.6e-16 56.8 6.6 0.00072 19.2 0.1 5.5 5 1 0 5 5 5 3 Kelch motif RAG2 PF03089.9 ESA05758.1 - 0.0043 15.8 0.3 1.2 7.7 0.0 2.8 2 1 0 3 3 3 2 Recombination activating protein 2 MULE PF10551.4 ESA05759.1 - 0.012 15.7 0.2 0.023 14.8 0.2 1.5 1 0 0 1 1 1 0 MULE transposase domain Phytoreo_Pns PF05451.6 ESA05759.1 - 0.088 11.4 2.5 0.63 8.6 0.2 2.3 2 1 0 2 2 2 0 Phytoreovirus nonstructural protein Pns10/11 TraT PF05818.7 ESA05760.1 - 0.047 13.1 0.2 0.075 12.4 0.1 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Cyclin PF08613.6 ESA05762.1 - 2.2e-35 122.2 0.2 2.9e-35 121.8 0.2 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESA05762.1 - 8.3e-05 22.1 0.2 0.00012 21.6 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Auxin_repressed PF05564.7 ESA05763.1 - 1.4 9.5 12.0 2.8 8.5 8.3 1.6 1 1 0 1 1 1 0 Dormancy/auxin associated protein Kdo_hydroxy PF11004.3 ESA05764.1 - 0.14 11.1 0.0 0.15 11.0 0.0 1.0 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase Cu-oxidase_3 PF07732.10 ESA05765.1 - 4.9e-40 135.9 1.7 6.5e-38 129.0 0.8 2.9 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 ESA05765.1 - 9e-34 116.6 0.0 2e-33 115.5 0.0 1.6 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA05765.1 - 0.0086 15.5 0.6 0.71 9.3 1.0 2.8 2 1 0 2 2 2 1 Multicopper oxidase PUF PF00806.14 ESA05767.1 - 0.04 13.4 0.2 0.067 12.6 0.1 1.4 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat TraT PF05818.7 ESA05769.1 - 0.027 13.8 0.2 6.2 6.1 0.0 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF2296 PF10058.4 ESA05769.1 - 0.03 14.0 3.0 3.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Fer4_17 PF13534.1 ESA05769.1 - 0.03 14.6 3.0 1.1 9.6 0.7 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESA05769.1 - 0.046 13.7 1.1 10 6.2 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Lar_restr_allev PF14354.1 ESA05769.1 - 0.051 13.8 0.5 0.58 10.5 0.2 2.3 2 0 0 2 2 2 0 Restriction alleviation protein Lar Fer4_10 PF13237.1 ESA05769.1 - 0.071 12.9 1.7 7.3 6.4 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_16 PF13484.1 ESA05769.1 - 0.2 12.4 5.0 6.5 7.5 0.0 2.8 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain zf-C4_ClpX PF06689.8 ESA05769.1 - 0.55 9.8 8.2 4.4 6.8 0.6 2.6 2 0 0 2 2 2 0 ClpX C4-type zinc finger zf-C2H2 PF00096.21 ESA05769.1 - 4.5 7.8 8.8 6.7 7.2 1.0 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF326 PF03860.11 ESA05769.1 - 7.5 6.5 8.0 12 5.9 0.7 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) DUF2431 PF10354.4 ESA05770.1 - 0.022 14.7 0.0 0.023 14.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) DUF2011 PF09428.5 ESA05770.1 - 0.071 12.9 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) Bax1-I PF01027.15 ESA05772.1 - 0.055 13.0 0.7 0.074 12.6 0.5 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF605 PF04652.11 ESA05772.1 - 6.2 6.1 20.1 7.8 5.7 13.9 1.1 1 0 0 1 1 1 0 Vta1 like TLD PF07534.11 ESA05773.1 - 3.3e-11 43.3 2.5 4.9e-11 42.7 1.7 1.3 1 0 0 1 1 1 1 TLD HdeA PF06411.6 ESA05775.1 - 0.036 14.0 0.1 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 HdeA/HdeB family DnaI_N PF07319.6 ESA05776.1 - 0.12 12.6 1.0 0.29 11.3 0.7 1.8 1 1 0 1 1 1 0 Primosomal protein DnaI N-terminus YABBY PF04690.8 ESA05776.1 - 0.16 12.1 3.7 0.23 11.6 2.5 1.4 1 1 0 1 1 1 0 YABBY protein Chitin_synth_2 PF03142.10 ESA05778.1 - 2.4e-172 574.0 1.6 2.4e-172 574.0 1.1 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA05778.1 - 4.1e-12 46.2 2.3 1.3e-11 44.5 1.6 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA05778.1 - 9.3e-10 38.6 0.0 1.3e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF726 PF05277.7 ESA05780.1 - 5e-54 183.4 0.1 5.4e-54 183.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.2 ESA05780.1 - 4.4e-05 23.4 0.0 4.5e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 ESA05780.1 - 0.0011 19.2 0.0 0.0015 18.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.2 ESA05780.1 - 0.0019 17.9 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.17 ESA05780.1 - 0.037 13.7 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 Cutinase Lipase_3 PF01764.20 ESA05780.1 - 0.039 13.5 0.0 0.057 13.0 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) VirJ PF06057.6 ESA05780.1 - 0.039 13.7 0.0 0.044 13.5 0.0 1.3 1 1 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF3089 PF11288.3 ESA05780.1 - 0.043 12.9 0.0 0.059 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Abhydrolase_9 PF10081.4 ESA05780.1 - 0.052 12.2 0.0 0.062 11.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family PE-PPE PF08237.6 ESA05780.1 - 0.057 12.8 0.0 0.098 12.0 0.0 1.4 1 1 0 1 1 1 0 PE-PPE domain DUF900 PF05990.7 ESA05780.1 - 0.073 12.3 0.0 0.087 12.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.8 ESA05780.1 - 0.1 12.1 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 PGAP1-like protein LCAT PF02450.10 ESA05780.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.15 ESA05780.1 - 0.13 11.8 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Y_phosphatase PF00102.22 ESA05781.1 - 3.8e-72 242.4 0.9 6.3e-72 241.7 0.6 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 ESA05781.1 - 4.1e-08 33.5 0.0 1.2e-07 32.0 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase3 PF13350.1 ESA05781.1 - 0.019 15.2 0.1 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family V4R PF02830.13 ESA05781.1 - 0.058 13.2 0.3 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 V4R domain DSPc PF00782.15 ESA05781.1 - 0.087 12.4 2.9 0.32 10.5 0.2 2.5 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain zf-BED PF02892.10 ESA05782.1 - 3.8e-05 23.3 1.1 6.7e-05 22.5 0.7 1.3 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_2 PF12756.2 ESA05782.1 - 0.0089 16.1 1.1 0.013 15.5 0.2 1.7 1 1 1 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 ESA05782.1 - 0.057 13.5 0.8 0.095 12.8 0.5 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Pec_lyase_N PF04431.8 ESA05782.1 - 0.14 12.2 0.1 0.26 11.4 0.1 1.6 1 1 0 1 1 1 0 Pectate lyase, N terminus DUF972 PF06156.8 ESA05783.1 - 0.0039 17.5 6.8 0.0061 16.8 4.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF972) Jnk-SapK_ap_N PF09744.4 ESA05783.1 - 0.0098 15.8 5.2 0.013 15.4 3.6 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 ATG16 PF08614.6 ESA05783.1 - 0.033 14.0 10.8 0.042 13.6 7.5 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2130 PF09903.4 ESA05783.1 - 0.074 11.7 12.4 0.097 11.3 8.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF3552 PF12072.3 ESA05783.1 - 0.094 11.9 8.0 0.12 11.6 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) LOH1CR12 PF10158.4 ESA05783.1 - 0.1 12.4 4.3 0.13 12.0 3.0 1.1 1 0 0 1 1 1 0 Tumour suppressor protein EF1G PF00647.14 ESA05783.1 - 0.14 11.8 4.1 0.18 11.4 2.6 1.4 1 1 0 1 1 1 0 Elongation factor 1 gamma, conserved domain GLE1 PF07817.8 ESA05783.1 - 0.25 10.2 5.3 0.3 9.9 3.7 1.1 1 0 0 1 1 1 0 GLE1-like protein BLOC1_2 PF10046.4 ESA05783.1 - 0.27 11.3 11.1 0.37 10.9 7.7 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.6 ESA05783.1 - 0.34 9.5 11.3 0.33 9.5 7.4 1.2 1 1 0 1 1 1 0 Spc7 kinetochore protein IncA PF04156.9 ESA05783.1 - 0.61 9.6 5.4 0.81 9.2 3.8 1.1 1 0 0 1 1 1 0 IncA protein HALZ PF02183.13 ESA05783.1 - 0.78 9.5 7.7 0.26 11.0 2.9 1.9 1 1 0 2 2 2 0 Homeobox associated leucine zipper DivIC PF04977.10 ESA05783.1 - 2.2 7.8 9.8 2.4 7.6 5.6 1.9 1 1 0 1 1 1 0 Septum formation initiator DUF3735 PF12537.3 ESA05783.1 - 2.6 8.1 5.0 8.9 6.4 3.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3735) BLOC1_2 PF10046.4 ESA05784.1 - 0.053 13.6 3.8 0.081 13.0 2.7 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_HK97_TLTM PF06120.6 ESA05784.1 - 0.067 12.5 0.4 0.1 11.9 0.2 1.3 1 1 0 1 1 1 0 Tail length tape measure protein GP41 PF00517.12 ESA05784.1 - 0.14 11.6 1.6 0.18 11.3 1.1 1.2 1 0 0 1 1 1 0 Retroviral envelope protein S-antigen PF05756.6 ESA05784.1 - 0.49 10.4 9.4 5.4 7.0 2.8 2.2 2 0 0 2 2 2 0 S-antigen protein MT0933_antitox PF14013.1 ESA05784.1 - 6.5 6.9 9.0 42 4.3 6.2 2.1 1 1 0 1 1 1 0 MT0933-like antitoxin protein DUF2407_C PF13373.1 ESA05786.1 - 0.55 10.1 3.1 1.5 8.7 0.4 2.4 2 1 0 2 2 2 0 DUF2407 C-terminal domain Fungal_trans PF04082.13 ESA05787.1 - 1.5e-34 119.0 2.2 2.6e-34 118.2 1.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ESA05787.1 - 3.5e-12 46.0 11.3 6e-12 45.2 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_1 PF00170.16 ESA05788.1 - 9.7e-07 28.6 12.7 1.3e-05 25.0 6.2 2.1 1 1 1 2 2 2 2 bZIP transcription factor Sec5 PF15469.1 ESA05788.1 - 0.0026 17.5 0.3 0.0029 17.3 0.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec5 ApoO PF09769.4 ESA05788.1 - 0.01 15.5 0.8 0.011 15.5 0.5 1.0 1 0 0 1 1 1 0 Apolipoprotein O Snapin_Pallidin PF14712.1 ESA05788.1 - 0.023 15.0 0.7 0.032 14.5 0.4 1.4 1 1 0 1 1 1 0 Snapin/Pallidin DUF1014 PF06244.7 ESA05788.1 - 0.07 13.3 0.5 0.089 13.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1014) Utp13 PF08625.6 ESA05788.1 - 0.072 12.7 0.1 0.081 12.5 0.1 1.2 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain bZIP_2 PF07716.10 ESA05788.1 - 0.098 12.4 12.5 0.19 11.5 5.6 2.1 1 1 1 2 2 2 0 Basic region leucine zipper PX PF00787.19 ESA05788.1 - 0.28 11.0 1.9 0.37 10.6 0.9 1.6 1 1 1 2 2 2 0 PX domain Myb_DNA-bind_6 PF13921.1 ESA05789.1 - 2e-05 24.6 3.5 2.5e-05 24.2 2.4 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA05789.1 - 0.011 15.7 0.5 0.035 14.1 0.1 1.9 1 1 1 2 2 2 0 Myb-like DNA-binding domain RhaT PF06379.7 ESA05790.1 - 0.027 13.4 0.8 0.3 10.0 0.6 2.0 1 1 0 1 1 1 0 L-rhamnose-proton symport protein (RhaT) PAP_central PF04928.12 ESA05794.1 - 1.3e-107 358.4 0.0 1.6e-107 358.0 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 ESA05794.1 - 1.2e-40 138.6 0.1 2e-40 137.8 0.1 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 ESA05794.1 - 1.3e-06 28.5 0.1 3.1e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain FBPase_2 PF06874.6 ESA05795.1 - 0.15 10.1 0.3 0.2 9.6 0.2 1.1 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Pkinase PF00069.20 ESA05799.1 - 1e-39 136.2 0.0 1.7e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05799.1 - 1.8e-36 125.5 0.0 2.4e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA05799.1 - 0.0084 15.1 0.0 0.023 13.7 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA05799.1 - 0.073 12.7 0.2 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pho88 PF10032.4 ESA05800.1 - 0.57 9.3 4.0 0.36 10.0 0.1 2.2 2 1 0 2 2 2 0 Phosphate transport (Pho88) ELMO_CED12 PF04727.8 ESA05800.1 - 0.65 9.5 3.8 0.95 8.9 0.2 2.0 2 0 0 2 2 2 0 ELMO/CED-12 family MerC PF03203.9 ESA05800.1 - 0.69 10.3 0.0 0.69 10.3 0.0 2.2 3 0 0 3 3 3 0 MerC mercury resistance protein BTB PF00651.26 ESA05802.1 - 1.3e-16 60.5 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Pkinase_Tyr PF07714.12 ESA05803.1 - 4.7e-20 71.7 0.0 8.5e-20 70.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05803.1 - 3.3e-15 55.9 0.0 7e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF605 PF04652.11 ESA05803.1 - 0.28 10.5 18.7 0.36 10.1 13.0 1.2 1 0 0 1 1 1 0 Vta1 like MoaE PF02391.12 ESA05804.1 - 1.2e-24 86.3 0.5 1.4e-24 86.1 0.4 1.1 1 0 0 1 1 1 1 MoaE protein Miro PF08477.8 ESA05804.1 - 0.05 14.0 0.0 0.058 13.8 0.0 1.2 1 0 0 1 1 1 0 Miro-like protein API5 PF05918.6 ESA05805.1 - 0.00027 19.5 0.2 0.0004 19.0 0.1 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) DUF884 PF05959.6 ESA05805.1 - 0.027 13.7 0.0 0.07 12.4 0.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF884) GTP_EFTU PF00009.22 ESA05806.1 - 2.1e-63 213.1 0.1 3.2e-63 212.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESA05806.1 - 1e-35 121.8 0.0 3.1e-35 120.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 ESA05806.1 - 1.7e-20 72.7 0.0 4.4e-20 71.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESA05806.1 - 4.6e-15 55.2 0.0 1.4e-14 53.6 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESA05806.1 - 1.9e-10 40.6 0.0 4.8e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 ESA05806.1 - 0.073 13.5 0.1 0.25 11.8 0.1 2.0 1 0 0 1 1 1 0 Miro-like protein Myb_DNA-binding PF00249.26 ESA05807.1 - 4.8e-19 68.1 2.6 3.9e-13 49.2 0.4 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA05807.1 - 2.2e-18 66.1 6.4 9.3e-13 48.0 0.3 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA05807.1 - 0.00065 19.8 3.7 0.095 12.9 0.4 2.2 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.1 ESA05807.1 - 0.00092 19.0 8.0 0.11 12.3 0.6 3.0 2 2 1 3 3 3 2 Myb/SANT-like DNA-binding domain MCRS_N PF13325.1 ESA05807.1 - 0.0038 16.7 0.6 0.0099 15.4 0.1 1.7 2 0 0 2 2 2 1 N-terminal region of micro-spherule protein Myb_DNA-bind_4 PF13837.1 ESA05807.1 - 0.015 15.4 8.2 1 9.5 1.7 2.6 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA05807.1 - 0.023 15.3 6.6 0.14 12.8 0.8 2.4 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF722 PF05263.6 ESA05807.1 - 0.027 14.6 3.2 1.1 9.4 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF722) Peptidase_M3_N PF08439.5 ESA05807.1 - 0.033 14.2 0.2 0.65 10.0 0.0 2.4 2 0 0 2 2 2 0 Oligopeptidase F Tox-REase-7 PF15649.1 ESA05807.1 - 0.079 13.0 1.2 0.11 12.6 0.3 1.6 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 7 Ssu72 PF04722.8 ESA05807.1 - 0.11 11.7 0.4 0.12 11.6 0.3 1.1 1 0 0 1 1 1 0 Ssu72-like protein DUF4375 PF14300.1 ESA05807.1 - 0.14 12.1 2.1 0.094 12.7 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) HMG_box PF00505.14 ESA05808.1 - 0.02 15.1 3.0 0.029 14.6 2.1 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA05808.1 - 0.079 13.3 3.0 0.13 12.6 2.1 1.5 1 0 0 1 1 1 0 HMG-box domain Cor1 PF04803.7 ESA05808.1 - 0.21 11.3 2.4 0.22 11.2 1.7 1.3 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region F-box-like PF12937.2 ESA05811.1 - 0.00086 18.9 3.7 0.00086 18.9 2.6 2.2 2 0 0 2 2 2 1 F-box-like DUF2178 PF09946.4 ESA05811.1 - 0.059 13.1 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) Phage-A118_gp45 PF10653.4 ESA05812.1 - 0.0011 18.8 1.2 17 5.3 0.0 5.4 6 0 0 6 6 6 1 Protein gp45 of Bacteriophage A118 ALS_ss_C PF10369.4 ESA05812.1 - 0.46 10.2 1.3 15 5.3 0.0 4.0 5 0 0 5 5 5 0 Small subunit of acetolactate synthase Pkinase_Tyr PF07714.12 ESA05813.1 - 5e-05 22.4 0.0 5.8e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05813.1 - 0.00014 21.1 0.0 0.00016 20.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DIRP PF06584.8 ESA05813.1 - 0.048 13.5 0.0 0.081 12.7 0.0 1.4 1 1 0 1 1 1 0 DIRP DNA_pol3_a_NII PF11490.3 ESA05813.1 - 0.073 12.6 1.0 0.078 12.5 0.1 1.5 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Pkinase PF00069.20 ESA05814.1 - 5.9e-08 32.1 0.2 6.5e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA05814.1 - 0.00012 21.1 0.2 0.00012 21.1 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.15 ESA05814.1 - 0.00094 18.4 0.1 0.0011 18.1 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase Pkinase_Tyr PF07714.12 ESA05814.1 - 0.0015 17.6 0.0 0.0017 17.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 ESA05814.1 - 0.0066 16.0 0.1 0.0078 15.8 0.1 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA05814.1 - 0.08 12.6 0.0 0.093 12.4 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.26 ESA05815.1 - 6.1e-07 29.4 0.0 7.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4098 PF13345.1 ESA05816.1 - 2.4e-11 43.4 25.2 4.6e-09 36.1 6.4 4.1 2 1 1 3 3 3 2 Domain of unknown function (DUF4098) DUF4097 PF13349.1 ESA05816.1 - 0.00019 20.9 4.4 0.0021 17.6 0.4 3.6 1 1 4 5 5 5 2 Domain of unknown function (DUF4097) FecR PF04773.8 ESA05816.1 - 0.00054 20.1 2.3 1 9.6 0.4 2.7 2 1 0 2 2 2 2 FecR protein Tail_tube PF10618.4 ESA05816.1 - 0.03 14.0 2.3 5.7 6.7 0.0 2.8 2 1 1 3 3 3 0 Phage tail tube protein JHBP PF06585.6 ESA05816.1 - 0.038 12.7 0.4 0.061 12.1 0.3 1.3 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) G8 PF10162.4 ESA05816.1 - 0.045 13.5 0.6 0.19 11.4 0.2 2.1 1 1 1 2 2 2 0 G8 domain META PF03724.11 ESA05816.1 - 0.15 11.9 0.1 0.7 9.7 0.0 2.0 1 1 1 2 2 2 0 META domain Fil_haemagg_2 PF13332.1 ESA05816.1 - 0.64 9.7 11.2 4.2 7.1 0.3 2.7 1 1 1 2 2 2 0 Haemagluttinin repeat DUF4048 PF13257.1 ESA05818.1 - 0.053 13.1 4.3 0.1 12.2 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) Gag_p17 PF00540.13 ESA05819.1 - 0.032 13.9 0.1 0.033 13.9 0.1 1.2 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) DUF4568 PF15132.1 ESA05819.1 - 0.04 13.1 0.0 0.041 13.0 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4568) HATPase_c PF02518.21 ESA05820.1 - 1.8e-26 92.0 0.0 3.3e-26 91.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 ESA05820.1 - 2.7e-23 82.0 0.1 8.7e-21 74.0 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain PRE_C2HC PF07530.6 ESA05820.1 - 0.076 12.9 0.0 10 6.1 0.0 2.5 2 0 0 2 2 2 0 Associated with zinc fingers ABC_membrane PF00664.18 ESA05821.1 - 9.6e-10 38.3 8.4 1.1e-09 38.1 5.8 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region Peptidase_A8 PF01252.13 ESA05821.1 - 0.16 11.6 3.3 0.14 11.7 0.2 2.2 2 1 0 2 2 2 0 Signal peptidase (SPase) II DUF2419 PF10343.4 ESA05822.1 - 2e-112 375.1 2.1 2.3e-112 374.9 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2419) CAP PF00188.21 ESA05823.1 - 4.7e-16 59.3 0.0 6.1e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Sel1 PF08238.7 ESA05825.1 - 1.5e-158 511.7 76.4 4.4e-11 43.0 0.4 16.7 17 0 0 17 17 17 15 Sel1 repeat TPR_6 PF13174.1 ESA05825.1 - 1.3e-08 34.7 35.7 7.2 7.3 0.1 13.6 14 0 0 14 14 14 4 Tetratricopeptide repeat Aldo_ket_red PF00248.16 ESA05825.1 - 0.0025 16.6 0.2 18 4.0 0.0 4.8 1 1 3 4 4 4 2 Aldo/keto reductase family TLE_N PF03920.10 ESA05825.1 - 1.2 8.9 16.9 13 5.5 0.1 6.3 3 3 3 7 7 7 0 Groucho/TLE N-terminal Q-rich domain SGT1 PF07093.6 ESA05826.1 - 2.7e-105 353.0 2.7 3.2e-105 352.7 1.9 1.0 1 0 0 1 1 1 1 SGT1 protein DOMON PF03351.12 ESA05827.1 - 3.8e-10 39.7 0.0 8.2e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.11 ESA05827.1 - 0.00023 20.9 14.6 0.00062 19.6 7.4 2.4 1 1 1 2 2 2 2 Eukaryotic cytochrome b561 DUF600 PF04634.7 ESA05828.1 - 0.024 14.6 1.1 0.049 13.6 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF600 NUP50 PF08911.6 ESA05828.1 - 0.097 13.0 0.4 0.097 13.0 0.3 2.5 3 0 0 3 3 3 0 NUP50 (Nucleoporin 50 kDa) Tau95 PF09734.4 ESA05829.1 - 0.0028 17.0 3.7 0.0035 16.7 2.6 1.1 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit hNIFK_binding PF12196.3 ESA05829.1 - 2.8 7.4 6.5 12 5.3 1.0 2.4 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK KH_1 PF00013.24 ESA05830.1 - 0.0001 21.8 0.7 0.0001 21.8 0.5 2.1 3 0 0 3 3 3 1 KH domain KH_3 PF13014.1 ESA05830.1 - 0.05 13.2 0.1 0.17 11.5 0.1 1.9 1 0 0 1 1 1 0 KH domain TPP_enzyme_N PF02776.13 ESA05832.1 - 1.5e-56 190.6 0.1 4e-56 189.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 ESA05832.1 - 5.9e-49 165.5 0.0 2.1e-47 160.5 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 ESA05832.1 - 3.8e-39 133.5 0.2 2.8e-38 130.7 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.11 ESA05832.1 - 0.028 13.9 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Sel1 PF08238.7 ESA05833.1 - 2.1e-183 590.7 83.9 2.8e-11 43.6 0.1 18.1 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA05833.1 - 2.2e-06 27.7 32.5 20 5.9 0.1 13.2 14 0 0 14 14 14 3 Tetratricopeptide repeat MscS_porin PF12795.2 ESA05833.1 - 1.6 8.0 9.0 5.8 6.1 0.2 4.3 5 0 0 5 5 5 0 Mechanosensitive ion channel porin domain Vps53_N PF04100.7 ESA05834.1 - 0.024 13.4 0.1 0.027 13.2 0.1 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal TCTP PF00838.12 ESA05836.1 - 0.22 11.5 2.6 0.26 11.2 0.1 2.0 2 0 0 2 2 2 0 Translationally controlled tumour protein FAR1 PF03101.10 ESA05837.1 - 6.2e-07 29.8 7.0 1.8e-06 28.4 4.8 1.7 1 1 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA05837.1 - 0.00037 20.0 1.1 0.025 14.1 0.1 2.5 2 0 0 2 2 2 2 MuDR family transposase IMD PF08397.6 ESA05837.1 - 0.014 14.7 2.4 0.018 14.3 0.8 1.7 2 0 0 2 2 2 0 IRSp53/MIM homology domain ATP-synt_8 PF00895.15 ESA05838.1 - 0.64 10.2 15.7 0.2 11.8 1.4 3.6 3 0 0 3 3 3 0 ATP synthase protein 8 Sel1 PF08238.7 ESA05839.1 - 1.8e-121 393.9 69.1 5e-10 39.6 0.2 15.0 15 0 0 15 15 15 15 Sel1 repeat TPR_6 PF13174.1 ESA05839.1 - 5.6e-09 35.8 27.5 2.8 8.6 0.1 10.6 10 1 0 10 10 10 5 Tetratricopeptide repeat DUF498 PF04430.9 ESA05839.1 - 0.11 12.0 0.0 8.5 5.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF498/DUF598) DUF3731 PF12531.3 ESA05839.1 - 0.19 11.2 0.0 18 4.7 0.0 3.2 4 0 0 4 4 4 0 DNA-K related protein EcsC PF12787.2 ESA05840.1 - 0.049 13.0 0.7 0.077 12.3 0.5 1.2 1 0 0 1 1 1 0 EcsC protein family AAA_19 PF13245.1 ESA05840.1 - 0.053 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESA05840.1 - 0.061 13.5 0.2 0.13 12.5 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 ESA05840.1 - 0.14 11.0 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Bromodomain PF00439.20 ESA05841.1 - 7e-16 57.9 2.7 1e-15 57.4 1.8 1.3 1 0 0 1 1 1 1 Bromodomain OB_RNB PF08206.6 ESA05841.1 - 0.092 12.2 0.2 0.2 11.1 0.1 1.6 2 0 0 2 2 2 0 Ribonuclease B OB domain Sad1_UNC PF07738.8 ESA05842.1 - 5.4e-32 110.4 0.0 1.1e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Prp19_bind PF06991.6 ESA05842.1 - 0.036 13.3 0.0 0.08 12.2 0.0 1.5 1 0 0 1 1 1 0 Splicing factor, Prp19-binding domain Seipin PF06775.9 ESA05843.1 - 4.7e-05 22.9 2.2 8.2e-05 22.2 1.5 1.4 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) NapE PF06796.6 ESA05843.1 - 0.037 13.3 0.4 0.064 12.5 0.3 1.5 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE SdpI PF13630.1 ESA05843.1 - 0.27 10.9 2.3 0.19 11.4 0.8 1.5 1 1 0 1 1 1 0 SdpI/YhfL protein family UPF0197 PF05251.7 ESA05843.1 - 0.61 10.4 4.9 0.91 9.8 3.4 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0197) GMC_oxred_C PF05199.8 ESA05844.1 - 4.2e-35 121.1 0.0 5.7e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 ESA05844.1 - 1.3e-06 27.8 0.0 2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pkinase_Tyr PF07714.12 ESA05845.1 - 5.3e-27 94.5 0.0 8e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05845.1 - 2.1e-26 92.6 1.7 6.4e-26 91.0 1.2 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA05845.1 - 0.0026 17.5 0.1 0.0035 17.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Stc1 PF12898.2 ESA05845.1 - 0.033 14.2 0.9 0.059 13.4 0.6 1.4 1 0 0 1 1 1 0 Stc1 domain Ribosomal_S2 PF00318.15 ESA05845.1 - 0.042 13.0 0.2 0.09 11.9 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S2 Nup35_RRM PF05172.8 ESA05845.1 - 0.1 12.3 0.5 2.3 8.0 0.1 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Pkinase PF00069.20 ESA05848.1 - 3.1e-19 69.1 0.7 3.8e-19 68.8 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05848.1 - 1.4e-18 66.9 0.1 1.7e-18 66.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA05849.1 - 2.5e-196 631.8 72.9 2.5e-08 34.2 0.1 28.9 29 0 0 29 29 29 27 Sel1 repeat TPR_6 PF13174.1 ESA05849.1 - 5.3e-12 45.3 51.9 1.1 9.8 0.0 18.9 23 0 0 23 23 23 5 Tetratricopeptide repeat RQC PF09382.5 ESA05849.1 - 0.00015 21.3 27.7 7.8 6.2 0.1 11.5 7 4 4 13 13 13 2 RQC domain Pkinase_Tyr PF07714.12 ESA05849.1 - 0.024 13.7 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2530 PF10745.4 ESA05849.1 - 0.22 11.5 0.4 2.1e+02 1.9 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2530) DUF2717 PF10911.3 ESA05849.1 - 2.6 7.6 17.5 10 5.6 0.3 5.8 6 0 0 6 6 6 0 Protein of unknown function (DUF2717) PAT1 PF09770.4 ESA05850.1 - 1.4 7.0 6.3 1.7 6.8 4.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Piwi PF02171.12 ESA05851.1 - 2e-79 266.7 0.5 4.7e-79 265.5 0.4 1.5 1 1 0 1 1 1 1 Piwi domain DUF4080 PF13311.1 ESA05851.1 - 0.1 12.6 1.3 0.57 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) DUF3895 PF13034.1 ESA05852.1 - 0.042 13.3 0.1 0.08 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3895) SET PF00856.23 ESA05853.1 - 3.3e-24 86.0 0.4 2.8e-23 83.0 0.3 2.2 1 1 0 1 1 1 1 SET domain Med26 PF08711.6 ESA05853.1 - 0.14 11.7 0.2 0.33 10.5 0.1 1.6 1 0 0 1 1 1 0 TFIIS helical bundle-like domain GvpK PF05121.7 ESA05856.1 - 0.13 12.0 0.1 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Gas vesicle protein K TetR_C_5 PF08360.6 ESA05856.1 - 0.14 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Sel1 PF08238.7 ESA05857.1 - 2.5e-112 364.8 55.4 9.6e-12 45.1 0.2 13.0 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA05857.1 - 4.7e-17 61.1 21.4 1.2 9.7 0.1 10.4 10 1 0 10 10 10 8 Tetratricopeptide repeat Siva PF05458.7 ESA05857.1 - 0.084 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) AraC_binding PF02311.14 ESA05858.1 - 0.065 12.9 0.0 0.066 12.8 0.0 1.0 1 0 0 1 1 1 0 AraC-like ligand binding domain YcxB PF14317.1 ESA05858.1 - 0.08 12.1 0.1 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 YcxB-like protein zf-C2H2 PF00096.21 ESA05859.1 - 3.3e-12 45.9 14.4 4.9e-07 29.7 0.8 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA05859.1 - 1.6e-08 34.2 19.3 9.2e-06 25.6 0.6 2.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA05859.1 - 1.1e-07 31.7 20.1 2.8e-05 24.1 5.6 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESA05859.1 - 0.0063 16.6 2.1 0.33 11.1 0.2 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 ESA05859.1 - 0.018 14.7 4.2 0.4 10.4 0.4 2.3 2 0 0 2 2 2 0 BED zinc finger zf-met PF12874.2 ESA05859.1 - 0.079 13.1 1.1 4.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ogr_Delta PF04606.7 ESA05859.1 - 0.15 11.6 2.4 7.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-C2H2_6 PF13912.1 ESA05859.1 - 0.59 10.1 3.8 0.81 9.6 0.1 3.0 3 1 0 3 3 3 0 C2H2-type zinc finger CHORD PF04968.7 ESA05859.1 - 0.66 10.2 5.0 5.2 7.3 0.2 2.5 1 1 1 2 2 2 0 CHORD zf-UBP PF02148.14 ESA05859.1 - 6.4 6.9 7.0 29 4.8 4.8 1.9 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein 4HBT PF03061.17 ESA05861.1 - 2.5e-09 37.1 0.0 0.0008 19.4 0.0 2.3 2 0 0 2 2 2 2 Thioesterase superfamily Helitron_like_N PF14214.1 ESA05862.1 - 1.1e-43 149.1 0.1 1.8e-43 148.3 0.1 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus SAM_1 PF00536.25 ESA05863.1 - 0.048 13.8 0.0 12 6.1 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF4098 PF13345.1 ESA05864.1 - 8.1e-06 25.7 20.4 0.00045 20.0 2.6 3.5 3 1 0 3 3 3 2 Domain of unknown function (DUF4098) Carn_acyltransf PF00755.15 ESA05865.1 - 2.8e-98 329.5 0.2 3.1e-98 329.3 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase BRAP2 PF07576.7 ESA05865.1 - 0.036 13.6 0.0 0.23 11.0 0.0 2.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 Cmc1 PF08583.5 ESA05866.1 - 2.4e-15 56.0 2.6 2.8e-15 55.8 1.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.8 ESA05866.1 - 0.051 12.9 0.8 0.063 12.7 0.6 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Dimer_Tnp_hAT PF05699.9 ESA05867.1 - 0.0012 18.4 0.0 0.0025 17.4 0.0 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TBX PF12598.3 ESA05868.1 - 0.082 13.2 2.4 0.13 12.6 1.7 1.4 1 1 0 1 1 1 0 T-box transcription factor YlbD_coat PF14071.1 ESA05869.1 - 0.041 13.9 0.6 0.28 11.2 0.3 1.9 1 1 1 2 2 2 0 Putative coat protein TLD PF07534.11 ESA05870.1 - 0.0015 18.5 0.2 0.0016 18.4 0.1 1.0 1 0 0 1 1 1 1 TLD LRR_4 PF12799.2 ESA05871.1 - 2.1 8.0 7.7 0.38 10.4 0.2 3.5 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Exo_endo_phos_2 PF14529.1 ESA05872.1 - 9e-06 25.2 0.1 6.3e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA05872.1 - 0.043 13.7 4.1 0.037 13.9 1.1 1.9 2 1 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family SprA-related PF12118.3 ESA05873.1 - 0.00012 21.5 14.0 0.00018 20.9 9.7 1.2 1 0 0 1 1 1 1 SprA-related family Spore_coat_CotO PF14153.1 ESA05873.1 - 0.00042 19.8 13.3 0.00069 19.1 9.2 1.3 1 0 0 1 1 1 1 Spore coat protein CotO SPX PF03105.14 ESA05873.1 - 0.0029 17.4 11.9 0.0038 17.0 8.3 1.2 1 0 0 1 1 1 1 SPX domain SDA1 PF05285.7 ESA05873.1 - 0.051 12.8 14.0 0.073 12.3 9.7 1.2 1 0 0 1 1 1 0 SDA1 ARGLU PF15346.1 ESA05873.1 - 0.23 11.2 24.5 0.39 10.4 17.0 1.2 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Zip PF02535.17 ESA05873.1 - 0.24 10.3 11.6 0.37 9.7 8.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FHIPEP PF00771.15 ESA05873.1 - 0.33 9.2 7.3 0.48 8.6 5.1 1.1 1 0 0 1 1 1 0 FHIPEP family Gti1_Pac2 PF09729.4 ESA05873.1 - 0.37 10.6 13.3 0.78 9.5 9.2 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.12 ESA05873.1 - 3.2 6.4 7.8 5.5 5.6 5.4 1.4 1 0 0 1 1 1 0 Presenilin MMR1 PF08505.5 ESA05873.1 - 3.5 7.6 24.0 0.49 10.3 12.2 2.0 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Daxx PF03344.10 ESA05873.1 - 3.6 5.9 22.2 5.1 5.4 15.4 1.1 1 0 0 1 1 1 0 Daxx Family PRP1_N PF06424.7 ESA05873.1 - 5.9 7.2 20.2 5 7.4 11.0 2.3 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal eIF3_subunit PF08597.5 ESA05873.1 - 6.7 6.2 18.7 11 5.4 13.0 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4407 PF14362.1 ESA05873.1 - 9.5 5.0 11.8 15 4.4 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MRC1 PF09444.5 ESA05874.1 - 0.25 11.6 6.7 2.1 8.6 0.2 2.2 2 0 0 2 2 2 0 MRC1-like domain Pkinase_Tyr PF07714.12 ESA05882.1 - 0.00018 20.6 0.0 0.00022 20.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase malic PF00390.14 ESA05884.1 - 0.025 14.1 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain DUF4283 PF14111.1 ESA05884.1 - 0.043 12.8 0.2 0.094 11.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4283) DUF1882 PF08966.6 ESA05884.1 - 0.062 13.2 0.3 0.11 12.4 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1882) DUF310 PF03750.8 ESA05884.1 - 0.28 11.3 2.7 0.48 10.6 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF310) Fungal_trans PF04082.13 ESA05887.1 - 9.4e-16 57.4 0.1 1.7e-15 56.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain OLF PF02191.11 ESA05888.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Olfactomedin-like domain Pkinase_Tyr PF07714.12 ESA05889.1 - 1.1e-34 119.7 0.0 1.3e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05889.1 - 2.5e-29 102.2 0.0 3.2e-29 101.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain PRESAN PF09687.5 ESA05890.1 - 0.1 12.6 0.5 0.13 12.3 0.4 1.2 1 0 0 1 1 1 0 Plasmodium RESA N-terminal zf-CCHC PF00098.18 ESA05891.1 - 0.0044 16.8 6.6 0.0044 16.8 4.5 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.1 ESA05891.1 - 0.056 13.1 3.8 0.12 12.0 2.7 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESA05891.1 - 0.075 12.7 1.4 0.19 11.4 0.9 1.7 1 0 0 1 1 1 0 Zinc knuckle NCU-G1 PF15065.1 ESA05892.1 - 0.066 11.8 0.1 0.063 11.9 0.1 1.0 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 p450 PF00067.17 ESA05896.1 - 3.3e-76 256.6 1.0 5.2e-76 256.0 0.7 1.2 1 0 0 1 1 1 1 Cytochrome P450 EVE PF01878.13 ESA05896.1 - 1.4e-06 28.3 0.0 3.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 EVE domain Med12 PF09497.5 ESA05897.1 - 1.3e-16 60.3 0.3 5.5e-16 58.3 0.0 2.2 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.3 ESA05897.1 - 4.4e-07 28.7 0.0 0.0001 20.9 0.0 3.1 1 1 1 2 2 2 1 Eukaryotic Mediator 12 subunit domain SPRY PF00622.23 ESA05899.1 - 2.7e-16 59.7 0.2 3e-16 59.6 0.1 1.0 1 0 0 1 1 1 1 SPRY domain Pox_P4B PF03292.9 ESA05900.1 - 0.017 13.0 0.7 0.02 12.8 0.5 1.0 1 0 0 1 1 1 0 Poxvirus P4B major core protein HSP20 PF00011.16 ESA05902.1 - 6.3e-24 83.7 0.1 7.7e-24 83.5 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF4097 PF13349.1 ESA05902.1 - 0.048 13.2 0.3 0.062 12.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4097) CS PF04969.11 ESA05902.1 - 0.12 12.9 0.1 0.3 11.6 0.1 1.7 1 1 0 1 1 1 0 CS domain DUF2435 PF10363.4 ESA05903.1 - 0.074 12.9 0.3 0.25 11.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) UCH PF00443.24 ESA05904.1 - 0.0038 16.3 0.5 0.0043 16.2 0.3 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Crystall_2 PF09076.5 ESA05904.1 - 0.086 12.6 0.1 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Beta/Gamma crystallin Sulfotransfer_3 PF13469.1 ESA05905.1 - 0.00048 21.0 0.0 0.00082 20.3 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase family UvrD-helicase PF00580.16 ESA05905.1 - 0.022 14.0 0.1 0.025 13.8 0.1 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Imm20 PF15568.1 ESA05905.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 20 Kelch_5 PF13854.1 ESA05907.1 - 2.3e-19 68.9 14.0 9.1e-05 22.3 0.2 5.9 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.1 ESA05907.1 - 2.6e-17 62.4 8.9 0.00032 20.7 0.0 6.3 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA05907.1 - 8.8e-16 57.3 14.4 0.0079 16.3 0.2 6.3 4 2 2 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA05907.1 - 2.9e-14 52.5 19.0 0.0045 16.7 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA05907.1 - 8.7e-11 41.1 14.6 0.00043 19.7 0.3 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA05907.1 - 5.3e-08 32.3 6.1 0.44 10.3 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Aconitase_2_N PF06434.8 ESA05907.1 - 0.14 11.5 2.2 6.9 6.0 0.1 2.4 2 0 0 2 2 2 0 Aconitate hydratase 2 N-terminus DUF2808 PF10989.3 ESA05910.1 - 0.038 13.6 0.8 0.048 13.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) DUF1505 PF07403.6 ESA05911.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1505) MreB_Mbl PF06723.8 ESA05913.1 - 0.00086 17.9 0.0 0.86 8.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA05913.1 - 0.00086 17.3 0.2 0.018 12.9 0.0 2.4 2 1 0 2 2 2 1 Hsp70 protein CTK3 PF12243.3 ESA05913.1 - 0.034 13.7 0.0 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 DUF843 PF05814.6 ESA05914.1 - 0.063 13.0 1.7 0.22 11.3 1.2 1.9 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) MIF PF01187.13 ESA05916.1 - 1.5e-17 63.7 0.0 1.7e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.16 ESA05916.1 - 0.0072 15.9 0.0 2.1 8.0 0.0 2.5 1 1 1 2 2 2 2 Tautomerase enzyme DEK_C PF08766.6 ESA05916.1 - 0.1 12.3 0.3 17 5.2 0.0 2.2 2 0 0 2 2 2 0 DEK C terminal domain Pho86 PF11124.3 ESA05917.1 - 1.2 8.0 4.1 1.4 7.8 2.8 1.0 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 DUF4448 PF14610.1 ESA05918.1 - 6.3e-05 22.5 0.1 7.5e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF2500 PF10694.4 ESA05918.1 - 0.00048 20.1 2.1 0.82 9.7 1.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2500) Adeno_E3_CR2 PF02439.10 ESA05918.1 - 0.0018 17.7 0.9 0.0018 17.7 0.6 1.6 2 0 0 2 2 2 1 Adenovirus E3 region protein CR2 DUF4293 PF14126.1 ESA05918.1 - 0.002 18.0 1.0 0.0029 17.5 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4293) EphA2_TM PF14575.1 ESA05918.1 - 0.0041 17.4 0.3 0.11 12.8 0.1 2.1 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain CoatB PF10389.4 ESA05918.1 - 0.013 15.3 1.5 0.03 14.1 1.1 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B OppC_N PF12911.2 ESA05918.1 - 0.023 14.0 1.4 0.48 9.8 0.3 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Rifin_STEVOR PF02009.11 ESA05918.1 - 0.028 14.0 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Rifin/stevor family YrhC PF14143.1 ESA05918.1 - 0.04 13.8 2.0 0.11 12.4 0.1 2.0 2 0 0 2 2 2 0 YrhC-like protein ABC2_membrane_4 PF12730.2 ESA05918.1 - 0.043 12.9 7.0 0.068 12.3 4.8 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein TrbC PF04956.8 ESA05918.1 - 0.044 13.7 7.0 0.062 13.3 1.0 2.0 1 1 1 2 2 2 0 TrbC/VIRB2 family 7TM_GPCR_Srd PF10317.4 ESA05918.1 - 0.055 12.4 1.4 0.067 12.1 1.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd DUF912 PF06024.7 ESA05918.1 - 0.059 13.4 2.8 0.066 13.2 1.1 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4064 PF13273.1 ESA05918.1 - 0.069 13.2 3.8 0.24 11.4 2.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF508 PF04370.7 ESA05918.1 - 0.1 12.1 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF508) OSTMP1 PF09777.4 ESA05918.1 - 0.16 11.1 0.1 0.26 10.4 0.0 1.4 2 0 0 2 2 2 0 Osteopetrosis-associated transmembrane protein 1 precursor TMEM154 PF15102.1 ESA05918.1 - 0.27 10.9 2.3 0.4 10.3 1.0 1.6 1 1 1 2 2 2 0 TMEM154 protein family Peptidase_S49_N PF08496.5 ESA05918.1 - 0.29 10.9 1.5 1.5 8.5 0.1 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Glucos_trans_II PF14264.1 ESA05918.1 - 0.37 9.7 3.9 1.3 7.9 1.0 1.9 1 1 1 2 2 2 0 Glucosyl transferase GtrII DUF3357 PF11837.3 ESA05918.1 - 0.38 10.6 3.7 2.2 8.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) ATP-synt_8 PF00895.15 ESA05918.1 - 0.4 10.9 4.0 2.6 8.2 0.2 2.4 2 1 0 2 2 2 0 ATP synthase protein 8 Baculo_11_kDa PF06143.6 ESA05918.1 - 0.5 9.7 4.0 1.1 8.7 0.8 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family ASFV_J13L PF05568.6 ESA05918.1 - 6.7 6.2 8.0 3.7 7.0 3.9 1.7 1 1 1 2 2 2 0 African swine fever virus J13L protein NDUF_B6 PF09782.4 ESA05919.1 - 0.026 14.3 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Shisa PF13908.1 ESA05920.1 - 0.03 14.5 0.6 0.069 13.3 0.4 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 ESA05920.1 - 0.054 13.2 0.3 0.054 13.2 0.2 2.1 1 1 1 2 2 2 0 TMEM154 protein family Baculo_11_kDa PF06143.6 ESA05920.1 - 0.15 11.4 1.0 0.52 9.7 0.3 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family Adeno_E3_CR2 PF02439.10 ESA05920.1 - 0.2 11.2 5.0 0.39 10.3 3.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 OppC_N PF12911.2 ESA05920.1 - 0.8 9.1 4.1 0.74 9.2 0.6 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MRP-L47 PF06984.8 ESA05921.1 - 2.2e-20 72.3 3.1 3.3e-20 71.7 2.1 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.18 ESA05921.1 - 0.043 13.5 0.4 3 7.5 0.0 2.5 2 0 0 2 2 2 0 Ribosomal L29 protein EF1G PF00647.14 ESA05922.1 - 1.2e-45 153.5 0.0 2.5e-45 152.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 ESA05922.1 - 7e-14 51.5 0.1 4.7e-13 48.9 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA05922.1 - 1.3e-12 47.6 0.1 4.3e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA05922.1 - 1e-07 31.7 0.0 3e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA05922.1 - 7.4e-07 29.5 0.1 3.6e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA05922.1 - 1.2e-05 25.3 0.0 3.4e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA05922.1 - 0.00016 21.6 0.0 0.00038 20.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain SHMT PF00464.14 ESA05923.1 - 2.4e-160 533.3 0.0 2.7e-160 533.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 ESA05923.1 - 4.7e-06 25.7 0.0 6.4e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESA05923.1 - 5.1e-05 22.5 0.0 0.0001 21.5 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase DUF4142 PF13628.1 ESA05923.1 - 0.088 12.8 0.6 0.18 11.7 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) FERM_N PF09379.5 ESA05924.1 - 0.078 13.0 0.8 4.8 7.3 0.1 2.5 2 1 0 2 2 2 0 FERM N-terminal domain Cep57_MT_bd PF06657.8 ESA05925.1 - 0.0029 17.5 0.5 0.1 12.5 0.0 2.5 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 Prefoldin PF02996.12 ESA05925.1 - 0.003 17.1 1.6 0.003 17.1 1.1 2.7 3 1 1 4 4 4 1 Prefoldin subunit DLD PF14878.1 ESA05925.1 - 0.38 10.8 5.9 0.11 12.6 1.6 2.0 2 1 0 2 2 2 0 Death-like domain of SPT6 HAUS2 PF15003.1 ESA05925.1 - 0.39 9.7 5.4 0.13 11.3 1.7 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 VWC PF00093.13 ESA05927.1 - 2.7 8.1 8.6 5 7.2 5.9 1.5 1 1 0 1 1 1 0 von Willebrand factor type C domain DUF3960 PF13142.1 ESA05929.1 - 0.086 12.6 0.2 0.091 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3960) Phospho_p8 PF10195.4 ESA05929.1 - 0.088 12.7 0.5 0.15 12.0 0.4 1.4 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 AA_permease_2 PF13520.1 ESA05930.1 - 2e-51 174.8 36.2 2e-51 174.8 25.1 1.2 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.16 ESA05930.1 - 1.1e-14 53.6 36.7 1.9e-14 52.8 25.4 1.4 1 1 0 1 1 1 1 Amino acid permease HMG_box PF00505.14 ESA05931.1 - 0.00035 20.7 0.0 0.0011 19.1 0.0 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box Pigment_DH PF06324.6 ESA05932.1 - 0.054 12.7 0.3 0.088 12.0 0.2 1.4 1 0 0 1 1 1 0 Pigment-dispersing hormone (PDH) HTH_28 PF13518.1 ESA05934.1 - 0.011 15.7 0.1 0.032 14.2 0.1 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.1 ESA05934.1 - 0.026 14.2 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain DUF4368 PF14287.1 ESA05934.1 - 0.062 13.1 0.9 0.11 12.3 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) CENP-B_N PF04218.8 ESA05934.1 - 0.16 11.3 1.2 0.32 10.4 0.6 1.8 1 1 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HMG_box PF00505.14 ESA05935.1 - 1.4e-06 28.5 0.2 5.4e-06 26.5 0.0 2.1 3 0 0 3 3 3 1 HMG (high mobility group) box Pox_polyA_pol_N PF12630.2 ESA05936.1 - 0.13 12.4 1.2 0.15 12.1 0.8 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain FTR1 PF03239.9 ESA05937.1 - 9.3e-43 146.3 12.1 1.8e-38 132.2 3.3 2.1 1 1 1 2 2 2 2 Iron permease FTR1 family DUF1129 PF06570.6 ESA05937.1 - 0.00079 18.7 5.1 0.00079 18.7 3.5 2.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1129) DUF4184 PF13803.1 ESA05937.1 - 0.02 14.2 3.9 0.041 13.1 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4184) Osmo_MPGsynth PF09488.5 ESA05937.1 - 0.021 13.4 0.0 0.029 13.0 0.0 1.2 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) TarH PF02203.10 ESA05937.1 - 0.024 14.4 1.2 0.19 11.5 0.2 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF418 PF04235.7 ESA05937.1 - 0.031 13.9 0.1 0.031 13.9 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF418) DUF4636 PF15468.1 ESA05937.1 - 0.091 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) EphA2_TM PF14575.1 ESA05937.1 - 0.89 9.9 4.7 3.5 8.0 0.0 3.1 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain DUF3671 PF12420.3 ESA05937.1 - 1.6 8.7 17.9 0.06 13.3 1.9 3.2 1 1 1 2 2 2 0 Protein of unknown function Orbi_NS3 PF01616.11 ESA05937.1 - 1.7 7.5 5.6 2.3 7.1 2.4 2.1 2 1 0 2 2 2 0 Orbivirus NS3 YrhC PF14143.1 ESA05937.1 - 2.6 8.0 6.2 5.2 7.0 1.3 2.7 2 0 0 2 2 2 0 YrhC-like protein 3HCDH PF00725.17 ESA05939.1 - 1.1e-17 64.1 0.0 1.3e-17 64.0 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain SWIM PF04434.12 ESA05940.1 - 5.3e-06 25.7 1.0 7.9e-06 25.2 0.7 1.3 1 0 0 1 1 1 1 SWIM zinc finger DUF1887 PF09002.6 ESA05940.1 - 0.18 10.1 0.3 0.23 9.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) Glycoprotein_B PF00606.13 ESA05942.1 - 0.067 11.2 0.0 0.067 11.2 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B FAD_binding_6 PF00970.19 ESA05947.1 - 1.9e-30 104.9 0.0 2.8e-30 104.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESA05947.1 - 7.4e-30 103.7 0.0 1.1e-29 103.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA05947.1 - 6.4e-06 26.1 0.0 1.6e-05 24.8 0.0 1.7 1 1 1 2 2 2 1 Ferric reductase NAD binding domain zf-BED PF02892.10 ESA05948.1 - 0.00068 19.3 3.8 0.0049 16.6 1.9 2.2 1 1 1 2 2 2 1 BED zinc finger TTL PF03133.10 ESA05948.1 - 0.045 12.6 0.5 0.069 12.0 0.0 1.5 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family DUF581 PF04570.9 ESA05948.1 - 0.11 11.8 1.0 1.8 7.9 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF581) YobH PF13996.1 ESA05949.1 - 0.081 12.8 0.1 0.19 11.6 0.0 1.7 1 1 0 1 1 1 0 YobH-like protein zf-C4_Topoisom PF01396.14 ESA05951.1 - 0.12 11.8 1.6 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Zn_ribbon_recom PF13408.1 ESA05951.1 - 0.16 12.2 2.4 0.23 11.7 1.6 1.6 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Pkinase PF00069.20 ESA05952.1 - 3.5e-28 98.4 0.0 6.5e-28 97.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05952.1 - 1e-25 90.3 0.0 1.2e-23 83.4 0.0 2.7 1 1 1 2 2 2 2 Protein tyrosine kinase WaaY PF06176.6 ESA05952.1 - 0.00053 19.2 0.5 0.001 18.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA05952.1 - 0.0011 18.7 0.1 0.0022 17.7 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA05952.1 - 0.0013 18.1 0.5 0.0028 17.0 0.1 1.7 2 0 0 2 2 2 1 RIO1 family TraT PF05818.7 ESA05955.1 - 0.00032 20.1 1.1 0.3 10.4 0.0 2.2 2 0 0 2 2 2 2 Enterobacterial TraT complement resistance protein Pkinase_Tyr PF07714.12 ESA05955.1 - 0.036 13.1 0.0 0.12 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase BACK PF07707.10 ESA05955.1 - 0.089 12.6 0.1 0.25 11.1 0.1 1.8 1 0 0 1 1 1 0 BTB And C-terminal Kelch Med27 PF11571.3 ESA05955.1 - 3.8 7.7 6.7 0.97 9.6 0.6 2.8 3 0 0 3 3 3 0 Mediator complex subunit 27 DUF1542 PF07564.6 ESA05956.1 - 0.0048 16.8 0.8 0.0094 15.9 0.6 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1542) DUF2206 PF09971.4 ESA05956.1 - 0.042 12.6 0.1 0.043 12.6 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) DUF3768 PF12599.3 ESA05956.1 - 0.049 13.5 0.2 0.055 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3768) RRM_1 PF00076.17 ESA05957.1 - 0.02 14.5 0.2 0.045 13.3 0.2 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA05957.1 - 0.048 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Acyltransferase PF01553.16 ESA05958.1 - 1.4e-15 56.9 0.0 2.4e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase FA_desaturase PF00487.19 ESA05958.1 - 0.043 13.2 5.9 0.07 12.5 4.1 1.3 1 0 0 1 1 1 0 Fatty acid desaturase CobD_Cbib PF03186.8 ESA05958.1 - 0.046 12.8 0.2 0.07 12.2 0.1 1.2 1 0 0 1 1 1 0 CobD/Cbib protein DUF3219 PF11514.3 ESA05958.1 - 0.11 12.4 0.2 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3219) Sel1 PF08238.7 ESA05959.1 - 4.3e-14 52.6 9.8 5.9e-08 33.1 0.1 3.3 3 1 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ESA05959.1 - 0.0083 16.5 2.2 0.77 10.3 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA05959.1 - 0.025 15.2 0.8 0.81 10.4 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA05959.1 - 0.071 13.4 0.5 6.2 7.2 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA05959.1 - 0.17 11.5 8.0 0.19 11.3 3.1 2.7 2 1 1 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESA05959.1 - 0.47 10.5 10.9 0.51 10.3 0.3 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat Mac-1 PF09028.5 ESA05960.1 - 0.0033 16.2 0.0 0.0041 15.9 0.0 1.1 1 0 0 1 1 1 1 Mac 1 TgMIC1 PF11476.3 ESA05961.1 - 0.054 13.0 0.1 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Chorion_2 PF03964.10 ESA05962.1 - 0.089 13.3 1.6 0.15 12.6 1.1 1.3 1 0 0 1 1 1 0 Chorion family 2 TraT PF05818.7 ESA05963.1 - 0.0018 17.7 2.0 2.3 7.5 0.0 3.3 3 0 0 3 3 3 2 Enterobacterial TraT complement resistance protein GATase_7 PF13537.1 ESA05963.1 - 0.014 15.1 0.0 1.1 9.0 0.0 3.4 4 0 0 4 4 4 0 Glutamine amidotransferase domain MerB PF03243.10 ESA05963.1 - 0.023 14.5 8.3 6.6 6.5 0.1 3.9 4 0 0 4 4 4 0 Alkylmercury lyase Fer4_9 PF13187.1 ESA05963.1 - 0.074 13.3 8.4 16 5.8 0.1 3.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain 7TM_transglut PF14402.1 ESA05963.1 - 0.42 9.5 3.0 25 3.6 0.0 3.0 3 0 0 3 3 3 0 7 transmembrane helices usually fused to an inactive transglutaminase Fer4_2 PF12797.2 ESA05963.1 - 3.3 7.8 11.3 10 6.2 0.3 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain HMG_box PF00505.14 ESA05965.1 - 9.4e-07 29.0 0.0 1.8e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA05965.1 - 0.00083 19.6 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain LRRC37AB_C PF14914.1 ESA05966.1 - 0.11 11.9 1.6 0.13 11.6 1.1 1.1 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DZR PF12773.2 ESA05967.1 - 0.00034 20.3 10.8 0.00087 19.0 7.5 1.7 1 1 0 1 1 1 1 Double zinc ribbon Pkinase_Tyr PF07714.12 ESA05967.1 - 0.021 13.9 0.0 0.038 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Phage_antiter_Q PF06323.6 ESA05967.1 - 0.055 12.8 0.1 0.098 12.0 0.1 1.4 1 0 0 1 1 1 0 Phage antitermination protein Q Prok-E2_E PF14462.1 ESA05967.1 - 0.22 11.0 0.8 0.32 10.5 0.0 1.6 2 0 0 2 2 2 0 Prokaryotic E2 family E Churchill PF06573.6 ESA05967.1 - 2.1 8.3 8.9 0.42 10.6 4.0 1.4 2 0 0 2 2 2 0 Churchill protein DUF3624 PF12292.3 ESA05967.1 - 3.7 8.0 8.9 0.58 10.5 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) PolC_DP2 PF03833.8 ESA05967.1 - 6.4 4.2 7.9 7.8 4.0 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 RecR PF02132.10 ESA05967.1 - 9.4 5.7 16.6 2.2 7.7 1.8 2.8 3 0 0 3 3 3 0 RecR protein APG6 PF04111.7 ESA05968.1 - 0.042 12.8 0.6 0.049 12.6 0.4 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 NuA4 PF09340.5 ESA05968.1 - 0.12 12.0 2.6 4.8 6.9 0.1 2.6 1 1 1 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF4472 PF14739.1 ESA05968.1 - 0.42 11.0 5.4 4.9 7.6 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Rad54_N PF08658.5 ESA05969.1 - 7.3e-10 38.9 10.6 1.4e-08 34.7 6.3 2.0 1 1 1 2 2 2 2 Rad54 N terminal PocR PF10114.4 ESA05970.1 - 0.009 15.1 0.1 3.6 6.7 0.0 2.9 2 1 0 2 2 2 2 Sensory domain found in PocR DUF2789 PF10982.3 ESA05970.1 - 0.011 15.6 0.8 12 6.0 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) Swi5 PF07061.6 ESA05970.1 - 0.044 13.5 2.2 4.4 7.1 0.1 2.8 2 0 0 2 2 2 0 Swi5 Med27 PF11571.3 ESA05970.1 - 0.14 12.3 4.2 0.47 10.5 0.2 2.7 2 0 0 2 2 2 0 Mediator complex subunit 27 F-box-like PF12937.2 ESA05971.1 - 9.5e-07 28.4 2.0 1.6e-06 27.6 0.3 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.2 ESA05971.1 - 0.00015 21.2 13.9 0.73 9.5 0.0 5.2 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA05971.1 - 0.0017 18.2 24.5 0.53 10.5 0.1 9.1 9 0 0 9 9 9 2 Leucine Rich repeat Thoc2 PF11732.3 ESA05971.1 - 0.048 13.4 0.0 0.75 9.6 0.0 2.6 2 0 0 2 2 2 0 Transcription- and export-related complex subunit F-box PF00646.28 ESA05971.1 - 0.14 11.8 2.1 0.68 9.6 0.0 3.1 3 0 0 3 3 3 0 F-box domain LRR_1 PF00560.28 ESA05971.1 - 0.15 12.1 18.1 0.9 9.8 0.1 6.8 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 ESA05971.1 - 3.8 8.1 21.8 2.1 8.9 0.3 6.7 6 1 2 8 8 8 0 Leucine rich repeat Cu-binding_MopE PF11617.3 ESA05972.1 - 0.015 15.1 1.3 0.029 14.1 0.0 2.2 2 0 0 2 2 2 0 Protein metal binding site F-box-like PF12937.2 ESA05973.1 - 0.003 17.2 0.7 0.01 15.5 0.5 1.9 1 0 0 1 1 1 1 F-box-like Phage_lysozyme PF00959.14 ESA05974.1 - 1.8e-20 73.2 0.0 2.1e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme Dimer_Tnp_hAT PF05699.9 ESA05976.1 - 8.2e-21 73.4 0.1 9.2e-21 73.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region MATH PF00917.21 ESA05977.1 - 0.052 13.7 0.3 0.066 13.4 0.2 1.3 1 1 0 1 1 1 0 MATH domain Pkinase_Tyr PF07714.12 ESA05978.1 - 1.9e-34 118.9 0.0 4.5e-34 117.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05978.1 - 1.2e-28 99.9 0.0 2e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05980.1 - 2.7e-39 134.8 0.0 6.3e-39 133.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05980.1 - 1.5e-34 119.3 0.0 2.6e-34 118.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MORN_2 PF07661.8 ESA05980.1 - 0.23 11.5 3.8 1.7 8.9 0.4 3.1 2 0 0 2 2 2 0 MORN repeat variant Dimer_Tnp_hAT PF05699.9 ESA05981.1 - 0.00014 21.4 0.3 0.00015 21.3 0.2 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2603 PF10788.4 ESA05982.1 - 0.017 14.8 0.7 0.027 14.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2603) LRR_4 PF12799.2 ESA05982.1 - 0.78 9.4 18.3 23 4.7 0.1 6.3 3 3 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA05982.1 - 0.95 9.7 0.0 0.95 9.7 0.0 5.0 5 2 1 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 ESA05982.1 - 7.8 7.1 11.3 3 8.4 0.1 5.7 8 0 0 8 8 8 0 Leucine rich repeat Sel1 PF08238.7 ESA05985.1 - 2.1e-12 47.2 4.2 0.00011 22.7 0.0 3.8 3 1 0 3 3 3 2 Sel1 repeat TPR_19 PF14559.1 ESA05985.1 - 0.0043 17.3 0.8 5.8 7.3 0.4 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat CHCH PF06747.8 ESA05985.1 - 0.0056 16.5 0.4 0.0094 15.8 0.3 1.4 1 0 0 1 1 1 1 CHCH domain TRL PF13146.1 ESA05985.1 - 0.025 14.5 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 TRL-like protein family TPR_6 PF13174.1 ESA05985.1 - 0.052 14.0 0.4 6.6 7.4 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Fer4_12 PF13353.1 ESA05985.1 - 0.094 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fis1_TPR_N PF14852.1 ESA05986.1 - 0.13 11.6 0.1 7.5 5.9 0.0 2.4 2 0 0 2 2 2 0 Fis1 N-terminal tetratricopeptide repeat BTB PF00651.26 ESA05987.1 - 2.2e-13 50.1 4.3 7.4e-13 48.4 0.2 2.6 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA05987.1 - 3e-07 30.2 0.8 3.7e-05 23.5 0.0 3.4 2 1 1 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA05988.1 - 3.5e-29 101.6 0.0 5.1e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05988.1 - 1.3e-28 99.8 0.0 2.2e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CRC_subunit PF08624.5 ESA05991.1 - 0.023 14.5 2.5 0.029 14.2 1.7 1.1 1 0 0 1 1 1 0 Chromatin remodelling complex Rsc7/Swp82 subunit Kinesin PF00225.18 ESA05992.1 - 1.3e-06 27.3 0.1 1.3e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain MHC_I PF00129.13 ESA05994.1 - 0.029 13.7 4.7 0.51 9.6 0.7 2.3 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Nucleotid_trans PF03407.11 ESA05994.1 - 0.045 13.5 1.7 1 9.0 0.5 2.3 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase Pkinase_Tyr PF07714.12 ESA05996.1 - 4.5e-34 117.6 0.0 5e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA05996.1 - 1.3e-32 112.9 0.0 1.5e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA05996.1 - 0.0043 16.8 0.3 0.0073 16.0 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA05996.1 - 0.044 12.8 0.2 0.068 12.2 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IGR PF09597.5 ESA05997.1 - 2.2e-20 72.3 0.0 3.3e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 IGR protein motif Pkinase PF00069.20 ESA05998.1 - 1.1e-64 218.1 0.0 1.2e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA05998.1 - 1.1e-44 152.4 0.0 1.5e-44 152.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA05998.1 - 4.3e-08 32.4 0.0 6.9e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA05998.1 - 0.0057 16.0 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA05998.1 - 0.0091 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESA05998.1 - 0.022 13.6 0.0 0.043 12.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.18 ESA05998.1 - 0.05 13.3 0.0 0.14 11.8 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Cas_Csa5 PF09702.5 ESA05999.1 - 0.082 13.0 0.1 0.39 10.8 0.0 2.1 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Csa5) MFS_1 PF07690.11 ESA06000.1 - 1.4e-41 142.4 31.8 1.4e-41 142.4 22.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA06000.1 - 4.5e-10 38.6 10.4 4.5e-10 38.6 7.2 2.6 3 1 0 3 3 3 1 Sugar (and other) transporter PUCC PF03209.10 ESA06000.1 - 0.00025 19.8 1.8 0.00055 18.7 1.2 1.6 1 0 0 1 1 1 1 PUCC protein YoqO PF14037.1 ESA06001.1 - 0.086 12.9 0.3 0.16 12.0 0.2 1.4 1 0 0 1 1 1 0 YoqO-like protein Phage_Treg PF04761.7 ESA06002.1 - 0.033 13.9 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator Cobl PF09469.5 ESA06002.1 - 0.048 13.6 1.3 0.056 13.4 0.9 1.2 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain DZR PF12773.2 ESA06003.1 - 0.047 13.5 12.4 1.3 8.9 0.7 3.3 3 0 0 3 3 3 0 Double zinc ribbon Zn-ribbon_8 PF09723.5 ESA06003.1 - 0.37 10.7 6.5 24 4.9 0.1 3.7 3 0 0 3 3 3 0 Zinc ribbon domain NOB1_Zn_bind PF08772.6 ESA06003.1 - 1 9.2 10.6 1.6 8.5 0.1 3.7 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like zf-HYPF PF07503.7 ESA06003.1 - 1.9 7.9 8.3 3.4 7.1 0.2 3.6 3 0 0 3 3 3 0 HypF finger DUF148 PF02520.12 ESA06003.1 - 2.1 8.1 9.0 26 4.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF2024 PF09630.5 ESA06003.1 - 4.2 7.1 7.0 19 5.0 0.5 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF2024) Snf7 PF03357.16 ESA06004.1 - 4.3e-22 78.3 8.9 4.8e-22 78.1 6.2 1.0 1 0 0 1 1 1 1 Snf7 SNAPc19 PF15497.1 ESA06004.1 - 1.8 8.8 5.9 3.1 8.0 4.1 1.5 1 1 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Sel1 PF08238.7 ESA06005.1 - 2.5e-162 523.8 93.1 2.3e-11 43.9 0.1 17.0 17 0 0 17 17 17 17 Sel1 repeat TPR_6 PF13174.1 ESA06005.1 - 1.3e-20 72.3 43.9 0.93 10.1 0.0 14.5 15 0 0 15 15 15 11 Tetratricopeptide repeat TPR_11 PF13414.1 ESA06005.1 - 0.00015 21.3 79.8 0.0013 18.3 1.2 11.3 5 3 5 11 11 11 8 TPR repeat TPR_16 PF13432.1 ESA06005.1 - 0.0007 20.2 29.8 0.21 12.3 0.0 10.5 7 4 7 14 14 14 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA06005.1 - 1.9 8.9 44.4 2.4 8.5 0.1 13.0 12 4 2 14 14 14 0 Tetratricopeptide repeat Gti1_Pac2 PF09729.4 ESA06006.1 - 2.8e-50 170.4 9.5 4.1e-41 140.6 2.0 2.0 1 1 1 2 2 2 2 Gti1/Pac2 family DUF91 PF01939.11 ESA06006.1 - 0.11 11.5 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF91 Cys_Met_Meta_PP PF01053.15 ESA06007.1 - 4.8e-155 515.6 0.2 5.5e-155 515.4 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 ESA06007.1 - 2.1e-06 26.9 0.1 2.9e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 ESA06007.1 - 0.00021 20.0 0.1 0.0003 19.5 0.1 1.1 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.14 ESA06007.1 - 0.00061 18.6 0.3 0.0022 16.8 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESA06007.1 - 0.0028 16.7 0.4 0.0062 15.6 0.2 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family TLD PF07534.11 ESA06008.1 - 7.6e-15 55.1 1.0 1e-14 54.6 0.7 1.2 1 0 0 1 1 1 1 TLD Pkinase PF00069.20 ESA06009.1 - 3.5e-66 223.0 0.0 4.3e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06009.1 - 1.4e-39 135.7 0.0 1.9e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA06009.1 - 3.7e-06 26.1 0.0 1.1e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 ESA06009.1 - 0.0004 20.2 0.0 0.0022 17.7 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA06009.1 - 0.067 12.5 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.6 ESA06009.1 - 0.12 11.2 0.0 0.21 10.3 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 BTB PF00651.26 ESA06010.1 - 1.1e-06 28.6 0.0 1.1e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA06011.1 - 1.7e-14 53.7 0.3 6.6e-14 51.8 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA06011.1 - 5.2e-06 26.2 3.3 3.5e-05 23.5 1.2 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch Tom22 PF04281.8 ESA06011.1 - 0.42 10.1 2.3 5.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 Cor1 PF04803.7 ESA06012.1 - 0.12 12.1 0.1 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region COX4 PF02936.9 ESA06013.1 - 0.13 11.9 0.0 0.14 11.8 0.0 1.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Band_7 PF01145.20 ESA06014.1 - 3.1e-14 53.2 1.0 4.4e-14 52.7 0.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 ESA06014.1 - 0.023 14.1 0.1 0.037 13.5 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family NSF PF02071.15 ESA06014.1 - 0.15 12.6 0.6 8.8 7.4 0.1 2.8 2 0 0 2 2 2 0 Aromatic-di-Alanine (AdAR) repeat Pkinase_Tyr PF07714.12 ESA06015.1 - 5e-54 183.1 0.0 5.6e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06015.1 - 2.3e-47 161.3 0.1 2.7e-47 161.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA06015.1 - 0.0034 17.1 0.0 0.0041 16.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA06015.1 - 0.0058 15.9 0.1 0.0086 15.4 0.1 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA06015.1 - 0.05 12.9 0.2 0.085 12.1 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA06015.1 - 0.052 12.6 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA06015.1 - 0.056 12.4 0.0 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kinesin-relat_1 PF12711.2 ESA06015.1 - 0.062 13.6 0.4 0.14 12.5 0.3 1.5 1 0 0 1 1 1 0 Kinesin motor Herpes_ori_bp PF02399.10 ESA06016.1 - 2.4e-08 32.4 0.0 3.4e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Origin of replication binding protein Radical_SAM PF04055.16 ESA06017.1 - 2.9e-09 37.3 0.3 7.9e-09 35.8 0.2 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Hepatitis_core PF00906.15 ESA06017.1 - 0.029 14.0 0.1 0.074 12.7 0.0 1.6 2 0 0 2 2 2 0 Hepatitis core antigen Mito_carr PF00153.22 ESA06018.1 - 5.7e-58 192.6 3.5 3.1e-19 68.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1647 PF07801.6 ESA06019.1 - 7e-07 28.8 0.0 1.1e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) LRR_6 PF13516.1 ESA06020.1 - 1.4 9.2 6.0 8.1 6.8 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.2 ESA06020.1 - 2.7 7.6 14.1 0.96 9.1 0.2 4.0 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) Herpes_ori_bp PF02399.10 ESA06021.1 - 5.7e-17 60.9 0.0 6.6e-15 54.1 0.0 2.1 2 0 0 2 2 2 2 Origin of replication binding protein Ribosomal_60s PF00428.14 ESA06022.1 - 0.095 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein BON PF04972.12 ESA06022.1 - 0.099 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 BON domain Striatin PF08232.7 ESA06024.1 - 0.0085 16.4 24.0 0.0085 16.4 16.6 6.0 3 1 3 6 6 6 1 Striatin family ERM PF00769.14 ESA06024.1 - 0.0086 15.6 41.4 0.0086 15.6 28.7 4.9 1 1 3 4 4 4 1 Ezrin/radixin/moesin family Herpes_ori_bp PF02399.10 ESA06026.1 - 5.1e-14 51.2 0.0 7.3e-14 50.7 0.0 1.1 1 0 0 1 1 1 1 Origin of replication binding protein DUF1428 PF07237.6 ESA06028.1 - 0.54 10.1 3.1 0.83 9.5 2.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1428) Pkinase PF00069.20 ESA06029.1 - 1.4e-46 158.7 0.2 1.6e-46 158.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06029.1 - 8.5e-10 38.1 0.0 1.1e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA06029.1 - 3.6e-06 26.9 0.3 1e-05 25.4 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA06029.1 - 0.0053 16.3 1.0 0.01 15.4 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.1 ESA06029.1 - 0.01 14.7 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 ESA06029.1 - 0.023 13.7 0.1 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA06029.1 - 0.058 12.7 0.1 0.086 12.1 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Methyltransf_FA PF12248.3 ESA06030.1 - 0.09 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Farnesoic acid 0-methyl transferase F-box-like PF12937.2 ESA06031.1 - 0.086 12.5 0.1 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 F-box-like GMC_oxred_N PF00732.14 ESA06032.1 - 1.4e-55 188.6 0.3 2.2e-55 187.8 0.2 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 ESA06032.1 - 4.3e-19 69.2 0.1 1.2e-17 64.5 0.0 2.4 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.19 ESA06032.1 - 3.7e-08 32.6 0.2 0.001 18.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 ESA06032.1 - 4.8e-07 28.9 1.6 5e-06 25.6 1.1 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA06032.1 - 0.00012 22.0 0.4 0.0024 17.8 0.1 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESA06032.1 - 0.00044 20.2 0.1 0.077 12.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase F-actin_cap_A PF01267.12 ESA06032.1 - 0.022 13.8 0.0 0.043 12.8 0.0 1.4 1 0 0 1 1 1 0 F-actin capping protein alpha subunit Thi4 PF01946.12 ESA06032.1 - 0.064 12.3 0.7 7.4 5.5 0.0 2.5 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.9 ESA06032.1 - 0.58 8.5 6.1 0.68 8.3 0.1 2.5 3 0 0 3 3 3 0 HI0933-like protein VPS11_C PF12451.3 ESA06033.1 - 0.88 9.4 0.1 0.88 9.4 0.1 2.4 3 1 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal EST1 PF10374.4 ESA06034.1 - 0.094 12.7 0.8 0.16 11.9 0.6 1.5 1 1 0 1 1 1 0 Telomerase activating protein Est1 INCENP_N PF12178.3 ESA06034.1 - 0.33 10.5 1.4 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal RNase_PH PF01138.16 ESA06036.1 - 6.6e-07 29.6 0.0 8e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 UQ_con PF00179.21 ESA06037.1 - 7.6e-39 132.3 0.0 8.4e-39 132.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESA06037.1 - 0.061 13.0 0.5 0.1 12.2 0.4 1.4 1 1 0 1 1 1 0 UEV domain RWD PF05773.17 ESA06037.1 - 0.076 12.9 0.1 0.096 12.5 0.1 1.4 1 0 0 1 1 1 0 RWD domain Herpes_ori_bp PF02399.10 ESA06040.1 - 1.5e-07 29.8 0.0 2.1e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Origin of replication binding protein DUF3624 PF12292.3 ESA06042.1 - 0.021 15.2 0.1 0.025 14.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) RNase_H PF00075.19 ESA06043.1 - 5.8e-15 55.7 0.0 1.1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 RNase H F-box-like PF12937.2 ESA06044.1 - 0.047 13.4 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 F-box-like HMG_box PF00505.14 ESA06046.1 - 2e-08 34.3 0.6 3.9e-08 33.4 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06046.1 - 5.3e-06 26.7 0.5 8.1e-06 26.1 0.3 1.3 1 0 0 1 1 1 1 HMG-box domain Paramyxo_PCT PF14320.1 ESA06047.1 - 0.065 12.1 0.2 0.087 11.6 0.1 1.1 1 0 0 1 1 1 0 Phosphoprotein P region PCT disordered DUF566 PF04484.7 ESA06047.1 - 4.5 6.7 9.9 4.9 6.5 6.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF4098 PF13345.1 ESA06048.1 - 3.2e-08 33.4 26.9 2.5e-07 30.5 6.9 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4098) DUF3980 PF13140.1 ESA06048.1 - 0.05 13.8 1.9 0.083 13.1 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3980) DUF4097 PF13349.1 ESA06048.1 - 1.9 8.0 27.8 0.51 9.8 2.8 4.7 2 2 2 4 4 4 0 Domain of unknown function (DUF4097) DUF1571 PF07608.6 ESA06049.1 - 0.035 13.2 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1571) RED_N PF07808.8 ESA06051.1 - 0.026 13.7 3.8 0.041 13.0 2.6 1.3 1 0 0 1 1 1 0 RED-like protein N-terminal region SPOB_ab PF14682.1 ESA06051.1 - 0.09 12.5 7.4 0.097 12.4 4.7 1.4 1 1 1 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal Bacillus_HBL PF05791.6 ESA06053.1 - 0.0085 15.4 0.4 0.012 14.9 0.3 1.2 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) Herpes_UL6 PF01763.11 ESA06053.1 - 0.013 13.7 0.1 0.013 13.7 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF972 PF06156.8 ESA06053.1 - 0.041 14.2 0.3 0.066 13.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Colicin-DNase PF12639.2 ESA06053.1 - 0.13 12.5 0.5 0.21 11.8 0.4 1.3 1 0 0 1 1 1 0 DNase/tRNase domain of colicin-like bacteriocin DUF3768 PF12599.3 ESA06055.1 - 1e-17 63.7 0.0 1.5e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3768) ROKNT PF08067.6 ESA06057.1 - 0.2 11.5 0.6 2.5 8.0 0.4 2.2 1 1 0 1 1 1 0 ROKNT (NUC014) domain KH_1 PF00013.24 ESA06058.1 - 2.2e-06 27.1 4.0 2.2e-06 27.1 2.8 1.8 2 1 0 2 2 2 1 KH domain KH_3 PF13014.1 ESA06058.1 - 1.1e-05 24.9 2.6 1.1e-05 24.9 1.8 1.9 2 0 0 2 2 2 1 KH domain KH_5 PF13184.1 ESA06058.1 - 0.014 15.1 0.5 0.031 14.0 0.4 1.6 1 0 0 1 1 1 0 NusA-like KH domain KH_4 PF13083.1 ESA06058.1 - 0.036 13.7 1.2 0.083 12.5 0.1 2.1 2 0 0 2 2 2 0 KH domain KH_2 PF07650.12 ESA06058.1 - 0.063 12.8 8.3 0.093 12.3 1.4 2.3 2 0 0 2 2 2 0 KH domain DUF1764 PF08576.5 ESA06058.1 - 2.5 8.9 7.9 4.1 8.2 5.4 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) KH_1 PF00013.24 ESA06059.1 - 1.9e-07 30.6 1.4 3.5e-07 29.7 1.0 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ESA06059.1 - 2.1e-05 24.0 0.4 5e-05 22.8 0.3 1.8 1 0 0 1 1 1 1 KH domain DUF929 PF06053.6 ESA06059.1 - 0.11 11.6 3.0 0.055 12.5 0.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF929) KH_4 PF13083.1 ESA06059.1 - 0.12 12.0 2.3 0.15 11.6 0.0 2.3 3 0 0 3 3 3 0 KH domain zf-CCCH PF00642.19 ESA06059.1 - 0.26 11.0 4.9 3.3 7.4 0.1 2.7 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3850 PF12961.2 ESA06059.1 - 2.7 8.0 6.1 0.27 11.2 0.4 2.2 2 1 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3850) zf-CCCH_2 PF14608.1 ESA06059.1 - 7.4 6.7 11.7 0.84 9.7 5.0 1.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type PAZ PF02170.17 ESA06060.1 - 3.5e-25 87.8 0.6 7.7e-25 86.7 0.1 1.7 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ESA06060.1 - 6.1e-16 57.5 0.0 1.3e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) DUF2183 PF09949.4 ESA06060.1 - 0.14 12.0 0.1 0.48 10.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) Chitin_synth_2 PF03142.10 ESA06061.1 - 3.9e-257 853.8 0.1 7.4e-257 852.9 0.0 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA06061.1 - 8e-16 58.3 3.9 3.5e-15 56.2 2.7 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA06061.1 - 3.6e-15 56.3 0.0 8.1e-14 51.9 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 ESA06061.1 - 0.00057 19.6 0.0 0.072 12.9 0.0 2.9 2 1 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 ESA06061.1 - 0.0058 15.9 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 21 BTB PF00651.26 ESA06062.1 - 2.9e-16 59.4 2.7 4.2e-16 58.9 1.5 1.6 1 1 0 1 1 1 1 BTB/POZ domain DUF1247 PF06851.6 ESA06062.1 - 0.00075 19.1 3.4 0.00075 19.1 2.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1247) F-box-like PF12937.2 ESA06063.1 - 5.9e-07 29.1 0.2 2.8e-06 26.9 0.2 2.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA06063.1 - 0.04 13.5 1.0 0.78 9.4 0.2 3.1 2 0 0 2 2 2 0 F-box domain Erf4 PF10256.4 ESA06064.1 - 0.0094 15.8 0.7 0.021 14.6 0.0 2.0 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family DUF3450 PF11932.3 ESA06064.1 - 0.67 9.1 3.6 0.16 11.2 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Autotransporter PF03797.14 ESA06066.1 - 0.034 13.4 0.0 0.037 13.3 0.0 1.0 1 0 0 1 1 1 0 Autotransporter beta-domain Methyltransf_11 PF08241.7 ESA06067.1 - 1.3e-15 57.6 0.0 3.2e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06067.1 - 1.4e-11 44.2 0.0 1.7e-10 40.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA06067.1 - 1.2e-10 41.6 0.0 3.5e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA06067.1 - 1.7e-10 40.8 0.0 2.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA06067.1 - 1.2e-08 35.5 0.0 1.1e-07 32.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA06067.1 - 3.4e-08 33.8 0.0 2.6e-07 31.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA06067.1 - 8.5e-07 28.3 0.1 6.3e-06 25.4 0.1 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 ESA06067.1 - 4.9e-06 26.5 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA06067.1 - 6.8e-06 25.2 0.0 6.8e-05 22.0 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.10 ESA06067.1 - 0.0003 20.4 0.0 0.0005 19.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_2 PF00891.13 ESA06067.1 - 0.00059 19.1 0.0 0.00085 18.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase MetW PF07021.7 ESA06067.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_29 PF03141.11 ESA06067.1 - 0.073 11.3 0.0 4.5 5.4 0.0 2.1 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF1493 PF07377.7 ESA06067.1 - 0.074 13.1 1.1 0.17 11.9 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) LRR_4 PF12799.2 ESA06068.1 - 1.2 8.7 9.3 0.48 10.1 1.7 2.5 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) KH_3 PF13014.1 ESA06069.1 - 3.1e-07 29.8 0.9 8.6e-07 28.4 0.7 1.7 1 0 0 1 1 1 1 KH domain KH_1 PF00013.24 ESA06069.1 - 9.1e-07 28.4 4.8 2.4e-06 27.0 3.3 1.7 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 ESA06069.1 - 0.0028 17.1 10.1 0.033 13.7 1.5 2.3 2 0 0 2 2 2 2 KH domain KH_5 PF13184.1 ESA06069.1 - 0.035 13.9 0.8 0.035 13.9 0.6 1.9 2 0 0 2 2 2 0 NusA-like KH domain KH_4 PF13083.1 ESA06069.1 - 0.092 12.4 0.6 0.092 12.4 0.4 2.2 2 1 1 3 3 3 0 KH domain GBP_C PF02841.9 ESA06069.1 - 0.32 10.1 6.0 0.42 9.7 4.1 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF1764 PF08576.5 ESA06069.1 - 6.8 7.5 10.2 11 6.8 7.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) bZIP_1 PF00170.16 ESA06070.1 - 1.5e-14 53.6 12.6 1.5e-14 53.6 8.7 2.9 2 1 1 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.10 ESA06070.1 - 2.1e-12 46.6 13.8 2.1e-12 46.6 9.6 3.2 3 0 0 3 3 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 ESA06070.1 - 3.3e-05 24.0 10.3 3.3e-05 24.0 7.1 3.6 2 2 1 3 3 3 1 bZIP Maf transcription factor DUF972 PF06156.8 ESA06070.1 - 0.0017 18.7 12.6 0.0017 18.7 8.7 3.0 2 2 1 3 3 3 2 Protein of unknown function (DUF972) HALZ PF02183.13 ESA06070.1 - 0.0047 16.6 8.9 0.45 10.2 1.3 2.7 2 0 0 2 2 2 2 Homeobox associated leucine zipper CCDC155 PF14662.1 ESA06070.1 - 0.0083 15.7 12.5 0.0083 15.7 8.6 2.8 2 1 1 3 3 3 2 Coiled-coil region of CCDC155 Kinetocho_Slk19 PF12709.2 ESA06070.1 - 0.013 15.6 1.7 0.013 15.6 1.2 3.7 2 1 1 3 3 3 0 Central kinetochore-associated Val_tRNA-synt_C PF10458.4 ESA06070.1 - 0.025 14.6 2.0 0.025 14.6 1.4 4.0 4 2 1 5 5 5 0 Valyl tRNA synthetase tRNA binding arm TBPIP PF07106.8 ESA06070.1 - 0.86 9.1 22.8 0.019 14.5 9.3 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) V_ATPase_I PF01496.14 ESA06070.1 - 1.6 6.4 18.0 2.1 6.0 12.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4140 PF13600.1 ESA06070.1 - 3.3 8.2 10.4 1.7 9.1 1.3 3.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) ubiquitin PF00240.18 ESA06070.1 - 3.6 7.0 7.7 0.47 9.8 1.1 2.4 2 1 0 2 2 2 0 Ubiquitin family Pkinase_Tyr PF07714.12 ESA06071.1 - 7.1e-08 31.8 0.0 1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06071.1 - 0.00025 20.2 0.1 0.00046 19.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain HMG_box PF00505.14 ESA06073.1 - 4.9e-12 45.9 2.6 4.9e-12 45.9 1.8 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06073.1 - 1.6e-06 28.3 3.1 2.5e-06 27.7 1.6 1.7 1 1 0 1 1 1 1 HMG-box domain N6_N4_Mtase PF01555.13 ESA06073.1 - 0.22 10.9 3.6 0.29 10.5 1.4 1.8 2 0 0 2 2 2 0 DNA methylase Inhibitor_I10 PF12559.3 ESA06074.1 - 0.0018 18.4 0.0 2.3 8.5 0.0 2.2 2 0 0 2 2 2 2 Serine endopeptidase inhibitors DUF538 PF04398.7 ESA06074.1 - 0.017 15.3 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF538 Arch_ATPase PF01637.13 ESA06074.1 - 0.057 13.1 0.6 8.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Archaeal ATPase PTS_EIIA_2 PF00359.17 ESA06074.1 - 0.068 12.8 2.0 8 6.1 0.0 2.5 3 0 0 3 3 3 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 DUF1888 PF08985.6 ESA06074.1 - 0.078 12.6 0.3 9.3 5.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1888) PAGK PF15284.1 ESA06074.1 - 0.22 11.3 2.6 13 5.5 0.1 2.7 2 0 0 2 2 2 0 Phage-encoded virulence factor MACPF PF01823.14 ESA06075.1 - 0.033 13.8 0.4 0.033 13.8 0.2 1.9 2 1 0 2 2 2 0 MAC/Perforin domain OTCace PF00185.19 ESA06075.1 - 0.078 12.8 0.8 0.11 12.3 0.1 1.7 2 0 0 2 2 2 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ARD PF03079.9 ESA06075.1 - 4.3 7.2 10.5 1.7 8.5 2.7 2.2 1 1 1 2 2 2 0 ARD/ARD' family Sec1 PF00995.18 ESA06076.1 - 1.4e-17 63.6 0.2 1.6e-17 63.4 0.1 1.0 1 0 0 1 1 1 1 Sec1 family Pribosyltran PF00156.22 ESA06076.1 - 0.036 13.8 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase domain DUF1673 PF07895.6 ESA06077.1 - 0.054 13.0 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Pkinase_Tyr PF07714.12 ESA06079.1 - 0.0054 15.8 0.0 0.0084 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MHC_I PF00129.13 ESA06081.1 - 0.083 12.2 0.6 0.14 11.5 0.4 1.5 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 zf-C4pol PF14260.1 ESA06083.1 - 0.072 13.1 0.6 0.11 12.4 0.4 1.5 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Fzo_mitofusin PF04799.8 ESA06083.1 - 0.1 11.9 1.2 0.54 9.6 0.3 1.9 2 0 0 2 2 2 0 fzo-like conserved region YhfH PF14149.1 ESA06083.1 - 0.86 9.4 4.2 17 5.3 0.6 2.7 3 0 0 3 3 3 0 YhfH-like protein BTB PF00651.26 ESA06084.1 - 2.4e-16 59.7 0.8 4.8e-16 58.7 0.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF3504 PF12012.3 ESA06085.1 - 0.049 13.4 0.0 0.13 11.9 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3504) RHH_1 PF01402.16 ESA06086.1 - 0.0015 18.2 1.6 0.0044 16.8 0.0 2.4 3 0 0 3 3 3 1 Ribbon-helix-helix protein, copG family RHH_3 PF12651.2 ESA06086.1 - 0.0029 17.3 0.3 0.0094 15.6 0.0 2.0 2 0 0 2 2 2 1 Ribbon-helix-helix domain DUF885 PF05960.6 ESA06086.1 - 0.0035 16.5 2.8 0.0043 16.2 2.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) NAAA-beta PF15508.1 ESA06086.1 - 0.008 16.5 1.5 0.35 11.2 0.1 2.7 3 1 1 4 4 4 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF4351 PF14261.1 ESA06086.1 - 0.025 14.4 0.0 0.066 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4351) Sec3_C_2 PF15278.1 ESA06086.1 - 0.025 14.6 0.6 0.054 13.6 0.4 1.6 1 0 0 1 1 1 0 Sec3 exocyst complex subunit IncA PF04156.9 ESA06086.1 - 0.031 13.8 3.3 0.039 13.5 2.3 1.3 1 0 0 1 1 1 0 IncA protein ApoLp-III PF07464.6 ESA06086.1 - 1.4 8.8 11.1 0.53 10.3 5.0 2.0 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Kelch_4 PF13418.1 ESA06089.1 - 1.6e-14 53.3 17.4 0.00075 19.2 0.0 8.6 6 3 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA06089.1 - 7.4e-14 51.3 0.5 0.00053 19.8 0.0 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA06089.1 - 1.2e-10 40.7 13.7 0.0029 17.1 0.0 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 ESA06089.1 - 1.2e-09 37.9 6.8 0.0065 16.5 0.0 6.5 6 2 0 6 6 6 2 Kelch motif Kelch_2 PF07646.10 ESA06089.1 - 5.1e-09 35.5 6.9 0.067 12.9 0.1 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA06089.1 - 7e-08 32.4 16.2 0.71 10.1 0.0 8.0 7 2 0 7 7 7 3 Galactose oxidase, central domain PQQ_3 PF13570.1 ESA06089.1 - 0.26 11.6 1.0 5.3 7.4 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain MHC_I_2 PF14586.1 ESA06091.1 - 0.21 11.1 2.5 0.41 10.2 1.2 1.7 1 1 1 2 2 2 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 Herpes_UL42 PF02282.11 ESA06094.1 - 0.079 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase processivity factor (UL42) DUF4561 PF15120.1 ESA06094.1 - 0.13 11.7 0.6 0.21 11.0 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4561) LRR_8 PF13855.1 ESA06096.1 - 0.053 13.2 0.5 20 5.0 0.0 3.5 2 1 2 4 4 4 0 Leucine rich repeat Pkinase PF00069.20 ESA06099.1 - 0.0001 21.5 0.0 0.00011 21.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF445 PF04286.7 ESA06101.1 - 0.0038 16.8 3.2 0.0055 16.2 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Phage_Integr_2 PF13009.1 ESA06101.1 - 0.017 14.0 0.1 0.019 13.9 0.1 1.0 1 0 0 1 1 1 0 Putative phage integrase DUF1104 PF06518.6 ESA06101.1 - 0.04 14.0 1.8 0.83 9.8 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) ApoLp-III PF07464.6 ESA06101.1 - 0.056 13.4 2.1 0.23 11.4 1.5 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) GlutR_dimer PF00745.15 ESA06101.1 - 0.071 13.0 0.6 0.45 10.4 0.2 1.9 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF883 PF05957.8 ESA06101.1 - 0.099 13.0 0.3 1.9 8.9 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) SecA_SW PF07516.8 ESA06101.1 - 0.1 12.3 2.1 0.12 12.1 1.5 1.1 1 0 0 1 1 1 0 SecA Wing and Scaffold domain DUF885 PF05960.6 ESA06101.1 - 0.12 11.5 0.2 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) ISG65-75 PF11727.3 ESA06101.1 - 0.33 9.9 3.0 0.4 9.6 2.1 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein ARGLU PF15346.1 ESA06101.1 - 0.55 9.9 3.8 1.8 8.3 2.3 1.9 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 YtxH PF12732.2 ESA06101.1 - 0.83 10.0 4.7 15 6.0 3.3 2.5 1 1 0 1 1 1 0 YtxH-like protein TA0956 PF11513.3 ESA06101.1 - 2.8 8.0 7.9 4 7.5 4.1 2.1 1 1 1 2 2 2 0 Thermoplasma acidophilum protein TA0956 Adeno_terminal PF02459.10 ESA06104.1 - 0.53 8.3 1.7 0.6 8.2 1.2 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF3661 PF12400.3 ESA06106.1 - 7.1e-38 129.6 14.6 1.2e-37 128.8 10.1 1.4 1 0 0 1 1 1 1 Vaculolar membrane protein Sec62 PF03839.11 ESA06106.1 - 1.8 7.9 9.7 1.1 8.5 1.0 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 HEAT PF02985.17 ESA06108.1 - 2.7e-20 70.5 9.5 0.0072 16.3 0.0 10.7 10 0 0 10 10 10 4 HEAT repeat HEAT_EZ PF13513.1 ESA06108.1 - 2.5e-19 69.1 5.8 6.1e-10 39.2 0.0 8.1 7 1 2 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.1 ESA06108.1 - 7.4e-17 61.4 9.4 4.4e-06 26.8 0.0 6.6 2 1 4 7 7 7 6 HEAT repeats IBN_N PF03810.14 ESA06108.1 - 2.8e-09 36.7 2.1 7.7e-09 35.3 0.4 2.7 2 1 1 3 3 3 1 Importin-beta N-terminal domain Arm PF00514.18 ESA06108.1 - 6.6e-06 25.7 9.6 0.041 13.7 0.0 6.5 7 0 0 7 7 5 2 Armadillo/beta-catenin-like repeat RIX1 PF08167.7 ESA06108.1 - 1.6e-05 24.6 8.8 0.039 13.6 0.0 5.6 4 2 2 6 6 6 1 rRNA processing/ribosome biogenesis CLASP_N PF12348.3 ESA06108.1 - 4.4e-05 22.9 6.7 0.011 15.0 0.3 5.2 3 2 2 5 5 5 1 CLASP N terminal Cnd1 PF12717.2 ESA06108.1 - 0.00026 20.8 0.2 0.02 14.7 0.0 3.7 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.5 ESA06108.1 - 0.00061 19.4 2.7 0.7 9.4 0.2 3.8 2 1 1 3 3 3 1 TATA-binding protein interacting (TIP20) FANCI_S3 PF14677.1 ESA06108.1 - 0.0092 15.3 3.3 3.6 6.9 0.2 4.0 3 1 0 4 4 4 1 FANCI solenoid 3 Proteasom_PSMB PF10508.4 ESA06108.1 - 0.0093 14.2 4.7 0.29 9.3 0.0 4.2 4 1 2 6 6 6 1 Proteasome non-ATPase 26S subunit Vac14_Fab1_bd PF12755.2 ESA06108.1 - 0.012 15.9 7.7 1.7 9.0 0.1 6.2 6 2 2 8 8 8 0 Vacuolar 14 Fab1-binding region DUF1546 PF07571.8 ESA06108.1 - 0.019 15.0 0.2 0.32 11.1 0.1 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF1546) Xpo1 PF08389.7 ESA06108.1 - 2.5 8.0 9.5 80 3.1 0.0 5.9 4 2 3 8 8 8 0 Exportin 1-like protein Yos1 PF08571.5 ESA06109.1 - 1.5e-29 101.9 5.4 1.7e-29 101.7 3.7 1.0 1 0 0 1 1 1 1 Yos1-like SET PF00856.23 ESA06110.1 - 1.8e-20 73.8 0.9 1.8e-20 73.8 0.6 2.4 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.11 ESA06110.1 - 2.4e-11 43.8 7.1 2.4e-11 43.8 4.9 2.1 2 0 0 2 2 2 1 Pre-SET motif UBA_4 PF14555.1 ESA06111.1 - 0.00055 19.4 1.1 0.0016 17.8 0.1 2.4 2 1 0 2 2 2 1 UBA-like domain Homeobox PF00046.24 ESA06111.1 - 0.0037 16.8 3.8 0.0037 16.8 2.6 2.6 2 0 0 2 2 2 1 Homeobox domain DASH_Duo1 PF08651.5 ESA06111.1 - 0.044 13.3 0.2 1.4 8.5 0.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 HBS1_N PF08938.5 ESA06111.1 - 0.11 12.6 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 HBS1 N-terminus DUF677 PF05055.7 ESA06111.1 - 0.13 10.8 0.3 0.22 10.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF677) Glyco_transf_15 PF01793.11 ESA06114.1 - 5.2e-134 446.3 23.8 5.9e-134 446.1 16.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Y_phosphatase2 PF03162.8 ESA06115.1 - 9.1e-40 135.7 0.1 9.4e-40 135.6 0.1 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESA06115.1 - 2.7e-06 27.7 0.0 3.4e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 ESA06115.1 - 0.001 18.6 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA06115.1 - 0.0059 15.9 0.0 0.0069 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.9 ESA06115.1 - 0.035 12.8 0.0 0.052 12.3 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DUF218 PF02698.12 ESA06120.1 - 0.0021 17.5 0.0 0.0037 16.7 0.0 1.5 1 1 0 1 1 1 1 DUF218 domain Pex14_N PF04695.8 ESA06120.1 - 0.0076 16.2 0.4 0.012 15.6 0.3 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Apis_Csd PF11671.3 ESA06120.1 - 0.096 12.4 12.8 0.17 11.6 8.9 1.5 1 0 0 1 1 1 0 Complementary sex determiner protein Pkinase PF00069.20 ESA06121.1 - 1.2e-08 34.4 0.0 2e-08 33.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06121.1 - 0.00072 18.7 0.0 0.00099 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase GAD-like PF08887.6 ESA06121.1 - 0.056 13.5 0.1 0.085 12.9 0.0 1.3 1 0 0 1 1 1 0 GAD-like domain ABC1 PF03109.11 ESA06121.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 ABC1 family Pkinase_Tyr PF07714.12 ESA06122.1 - 7.2e-15 54.7 0.2 5e-14 51.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06122.1 - 5.1e-08 32.3 0.1 2e-07 30.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain ECM11 PF15463.1 ESA06122.1 - 0.13 12.5 8.5 1.5 9.0 1.9 2.4 1 1 1 2 2 2 0 Extracellular mutant protein 11 RNA_bind PF08675.6 ESA06124.1 - 0.084 12.8 0.2 0.34 10.9 0.0 2.0 2 0 0 2 2 2 0 RNA binding domain DUF3540 PF12059.3 ESA06124.1 - 0.099 12.2 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) PI31_Prot_C PF08577.6 ESA06129.1 - 7e-07 29.8 1.4 7e-07 29.8 0.9 2.2 2 1 1 3 3 3 1 PI31 proteasome regulator TraQ PF09679.5 ESA06130.1 - 0.015 15.2 0.1 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) DUF464 PF04327.7 ESA06130.1 - 0.065 13.4 1.2 3.4 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF464) RRM_2 PF04059.7 ESA06130.1 - 0.072 13.1 0.4 0.15 12.1 0.3 1.7 1 1 0 1 1 1 0 RNA recognition motif 2 Imm22 PF15592.1 ESA06131.1 - 0.074 13.3 1.2 0.33 11.2 0.1 2.1 1 1 0 2 2 2 0 Immunity protein 22 APH PF01636.18 ESA06135.1 - 3.4e-16 59.6 0.0 1.4e-15 57.6 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA06135.1 - 0.00036 20.1 0.4 0.00075 19.1 0.3 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase YuiB PF14068.1 ESA06137.1 - 0.13 12.6 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Putative membrane protein UDPGT PF00201.13 ESA06139.1 - 1.8e-22 79.5 0.0 2.3e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA06139.1 - 1.8e-08 34.2 0.0 2.5e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA06139.1 - 0.00067 18.9 0.0 0.0014 17.8 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 1 SWIRM PF04433.12 ESA06140.1 - 4.2e-06 26.8 0.1 2e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 SWIRM domain zf-C2H2 PF00096.21 ESA06141.1 - 0.0014 18.8 0.3 0.003 17.8 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA06141.1 - 0.0023 18.0 0.1 0.0023 18.0 0.1 2.1 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding DUF842 PF05811.8 ESA06141.1 - 0.057 12.8 1.0 0.11 12.0 0.7 1.6 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) zf-C2H2_4 PF13894.1 ESA06141.1 - 0.057 13.7 0.1 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1661 PF07877.6 ESA06141.1 - 0.26 10.8 2.4 0.48 9.9 0.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1661) zf-C2H2_6 PF13912.1 ESA06141.1 - 0.74 9.8 3.8 0.81 9.6 1.6 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger F-112 PF09645.5 ESA06142.1 - 0.11 12.4 0.0 6.3 6.7 0.0 2.1 2 0 0 2 2 2 0 F-112 protein DUF2779 PF11074.3 ESA06144.1 - 8.9 6.3 10.1 4.8 7.2 0.6 3.1 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) CBM_21 PF03370.8 ESA06145.1 - 7.5e-32 109.6 4.2 2e-31 108.2 2.9 1.8 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit HGTP_anticodon PF03129.15 ESA06146.1 - 1.6e-19 69.6 0.0 4.5e-19 68.1 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.20 ESA06146.1 - 1.2e-15 57.5 0.0 2.3e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SieB PF14163.1 ESA06146.1 - 0.012 15.1 0.1 0.024 14.2 0.1 1.4 1 0 0 1 1 1 0 Superinfection exclusion protein B PYRIN PF02758.11 ESA06146.1 - 0.076 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain Rep_1 PF01446.12 ESA06148.1 - 0.005 16.2 0.1 0.0051 16.1 0.0 1.1 1 0 0 1 1 1 1 Replication protein LRR_4 PF12799.2 ESA06149.1 - 0.031 13.9 3.5 3.5 7.3 0.0 3.6 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) DUF3600 PF12207.3 ESA06149.1 - 0.074 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3600) Rad51 PF08423.6 ESA06154.1 - 0.022 13.6 0.0 0.023 13.6 0.0 1.0 1 0 0 1 1 1 0 Rad51 DUF1869 PF08956.5 ESA06154.1 - 0.038 13.5 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) Latrotoxin_C PF15658.1 ESA06154.1 - 0.059 13.1 0.4 0.071 12.9 0.3 1.0 1 0 0 1 1 1 0 Latrotoxin C-terminal domain SUFU PF05076.8 ESA06156.1 - 0.056 13.0 0.0 0.061 12.8 0.0 1.1 1 0 0 1 1 1 0 Suppressor of fused protein (SUFU) GIDA PF01134.17 ESA06156.1 - 0.063 12.1 0.8 0.074 11.8 0.6 1.0 1 0 0 1 1 1 0 Glucose inhibited division protein A AWPM-19 PF05512.6 ESA06156.1 - 0.096 12.6 0.1 0.16 11.9 0.0 1.4 1 1 0 1 1 1 0 AWPM-19-like family PTSIIB_sorb PF03830.10 ESA06157.1 - 0.089 12.6 0.3 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component MRAP PF15183.1 ESA06158.1 - 0.09 12.3 3.4 0.098 12.2 2.4 1.1 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family DUF3797 PF12677.2 ESA06161.1 - 0.7 9.5 3.0 1.7 8.3 1.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) F-box-like PF12937.2 ESA06162.1 - 6.2e-08 32.2 1.7 6.1e-07 29.0 0.6 2.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA06162.1 - 0.019 14.6 0.5 0.019 14.6 0.4 2.2 2 0 0 2 2 2 0 F-box domain DUF900 PF05990.7 ESA06163.1 - 0.0096 15.2 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Acetyltransf_4 PF13420.1 ESA06163.1 - 0.027 14.4 0.1 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Hjc PF01870.13 ESA06163.1 - 0.033 13.7 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) DUF676 PF05057.9 ESA06163.1 - 0.054 12.7 0.0 0.086 12.1 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Pkinase_Tyr PF07714.12 ESA06164.1 - 2e-20 72.9 0.1 2.5e-20 72.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06164.1 - 4.6e-19 68.5 0.1 5.5e-19 68.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain MIR PF02815.14 ESA06166.1 - 5.6e-10 39.0 0.6 5.9e-06 25.9 0.1 2.5 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA06166.1 - 8.5e-07 28.2 0.1 1.3e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor TRAPPC10 PF12584.3 ESA06166.1 - 0.026 14.0 0.1 0.042 13.3 0.1 1.3 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 FliG_N PF14842.1 ESA06166.1 - 0.16 12.0 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 FliG N-terminal domain Pkinase_Tyr PF07714.12 ESA06167.1 - 0.0091 15.0 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MHC_I PF00129.13 ESA06167.1 - 0.1 11.9 0.5 0.15 11.3 0.1 1.4 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 DIM PF08194.7 ESA06167.1 - 0.43 10.5 3.1 0.78 9.7 2.1 1.5 1 0 0 1 1 1 0 DIM protein Tet_res_leader PF08050.7 ESA06167.1 - 4 7.1 9.8 7.7 6.2 6.8 1.4 1 0 0 1 1 1 0 Tetracycline resistance leader peptide MACPF PF01823.14 ESA06170.1 - 3.2e-08 33.5 4.5 7.3e-08 32.3 3.1 1.6 1 0 0 1 1 1 1 MAC/Perforin domain DUSP PF06337.7 ESA06170.1 - 0.072 13.4 0.5 0.072 13.4 0.3 2.9 3 1 0 3 3 3 0 DUSP domain Cullin_binding PF03556.10 ESA06171.1 - 0.037 14.1 0.2 0.051 13.7 0.1 1.2 1 0 0 1 1 1 0 Cullin binding Thioredoxin_6 PF13848.1 ESA06171.1 - 0.043 13.6 0.2 0.043 13.6 0.1 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain DUF3684 PF12449.3 ESA06172.1 - 1.1e-09 36.5 0.0 1.8e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) Nucleotid_trans PF03407.11 ESA06172.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase CIA30 PF08547.7 ESA06175.1 - 2.5e-33 115.1 0.0 3.1e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CagX PF03524.10 ESA06177.1 - 0.017 14.3 1.5 0.022 14.0 1.0 1.1 1 0 0 1 1 1 0 Conjugal transfer protein AAA_23 PF13476.1 ESA06177.1 - 0.019 15.2 5.1 0.02 15.1 3.5 1.1 1 0 0 1 1 1 0 AAA domain BRF1 PF07741.8 ESA06177.1 - 0.026 14.7 6.5 0.034 14.3 4.5 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain PP_M1 PF03012.9 ESA06177.1 - 0.063 12.6 4.7 0.076 12.3 3.3 1.1 1 0 0 1 1 1 0 Phosphoprotein SGT1 PF07093.6 ESA06177.1 - 0.08 11.3 7.0 0.092 11.1 4.9 1.0 1 0 0 1 1 1 0 SGT1 protein FimP PF09766.4 ESA06177.1 - 0.2 10.6 8.9 0.24 10.4 6.2 1.1 1 0 0 1 1 1 0 Fms-interacting protein PBP_sp32 PF07222.7 ESA06177.1 - 0.48 9.5 5.8 0.53 9.4 4.0 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF3043 PF11241.3 ESA06177.1 - 3.1 7.3 5.4 3.9 7.0 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) RNA_pol_Rpo13 PF12136.3 ESA06177.1 - 3.9 7.2 6.8 8.3 6.1 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain DUF679 PF05078.7 ESA06181.1 - 0.076 12.6 0.1 0.077 12.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF679) Herpes_ori_bp PF02399.10 ESA06184.1 - 5.2e-16 57.8 1.2 1.3e-14 53.2 0.4 2.1 1 1 0 2 2 2 2 Origin of replication binding protein DUF3746 PF12562.3 ESA06186.1 - 0.065 13.0 3.4 1.8 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3746) DUF3246 PF11596.3 ESA06187.1 - 0.048 12.9 1.2 0.05 12.8 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) SNF2_N PF00176.18 ESA06189.1 - 9.6e-52 175.6 0.5 1.5e-51 175.0 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 ESA06189.1 - 6.6e-36 122.6 0.8 6.6e-36 122.6 0.6 2.1 2 0 0 2 2 2 1 SLIDE HAND PF09110.6 ESA06189.1 - 3e-29 101.6 5.2 1.3e-28 99.6 3.6 2.2 1 0 0 1 1 1 1 HAND Helicase_C PF00271.26 ESA06189.1 - 1e-15 57.3 0.0 3.1e-15 55.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA06189.1 - 0.00011 22.0 0.0 0.00058 19.7 0.0 2.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Myb_DNA-bind_6 PF13921.1 ESA06189.1 - 0.0056 16.7 0.4 0.042 13.9 0.1 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain DEAD PF00270.24 ESA06189.1 - 0.0066 15.9 0.0 0.016 14.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.1 ESA06189.1 - 0.023 14.6 0.0 0.094 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.26 ESA06189.1 - 0.023 14.7 0.0 0.56 10.3 0.0 2.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain AAA_22 PF13401.1 ESA06189.1 - 0.13 12.3 1.0 0.69 10.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESA06189.1 - 1 8.7 0.0 1 8.7 0.0 3.0 2 1 0 2 2 1 0 AAA-like domain DNA_pol_B_exo1 PF03104.14 ESA06191.1 - 1.5e-06 27.3 1.3 0.00062 18.7 0.4 2.1 1 1 1 2 2 2 2 DNA polymerase family B, exonuclease domain GATA PF00320.22 ESA06192.1 - 4.6e-07 29.0 2.2 8.9e-07 28.1 1.5 1.5 1 0 0 1 1 1 1 GATA zinc finger UPF0449 PF15136.1 ESA06193.1 - 0.063 13.4 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 LPAM_1 PF08139.7 ESA06195.1 - 0.057 13.6 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DUF4515 PF14988.1 ESA06197.1 - 0.00054 19.6 3.7 0.00054 19.6 2.6 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4515) IncA PF04156.9 ESA06197.1 - 0.0025 17.4 9.7 0.0055 16.3 6.7 1.5 1 0 0 1 1 1 1 IncA protein Med9 PF07544.8 ESA06197.1 - 0.026 14.2 1.1 0.026 14.2 0.7 3.4 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF1777 PF08648.7 ESA06197.1 - 0.034 13.8 3.1 0.057 13.1 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF4200 PF13863.1 ESA06197.1 - 0.035 14.0 0.7 0.035 14.0 0.5 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) BBP1_C PF15272.1 ESA06197.1 - 0.04 13.4 8.2 0.12 11.9 1.0 2.5 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal TMF_DNA_bd PF12329.3 ESA06197.1 - 0.12 12.1 17.6 0.14 11.9 0.4 2.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding CENP-Q PF13094.1 ESA06197.1 - 0.32 11.0 7.6 0.7 9.9 0.4 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.6 ESA06197.1 - 1.1 7.8 13.9 1.1 7.8 0.8 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2570 PF10828.3 ESA06197.1 - 2.9 7.5 12.9 1.6 8.4 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Spectrin PF00435.16 ESA06197.1 - 3.6 7.9 9.8 9.2 6.6 2.3 2.8 1 1 0 2 2 2 0 Spectrin repeat Fib_alpha PF08702.5 ESA06197.1 - 8 6.5 13.2 17 5.4 0.2 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ATG16 PF08614.6 ESA06197.1 - 8.2 6.1 20.2 4.7 6.9 1.6 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FRG1 PF06229.7 ESA06198.1 - 7.7e-31 107.0 0.8 7.7e-31 107.0 0.6 1.6 2 0 0 2 2 2 1 FRG1-like family Fascin PF06268.8 ESA06198.1 - 0.00037 20.5 0.0 0.00072 19.6 0.0 1.5 1 0 0 1 1 1 1 Fascin domain DUF1754 PF08555.5 ESA06198.1 - 0.041 14.4 5.6 0.041 14.4 3.9 2.6 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) PPI_Ypi1 PF07491.6 ESA06199.1 - 2.3e-23 81.5 1.2 5.2e-23 80.4 0.8 1.6 1 0 0 1 1 1 1 Protein phosphatase inhibitor Ribosomal_L3 PF00297.17 ESA06200.1 - 7.1e-35 120.6 0.1 9.5e-35 120.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L3 TLD PF07534.11 ESA06201.1 - 2.7e-11 43.6 1.7 2.2e-10 40.6 0.8 2.5 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA06201.1 - 5.5e-05 22.9 0.7 0.00071 19.3 0.1 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA06202.1 - 5.5e-11 42.0 0.0 2.6e-10 39.7 0.0 2.2 1 0 0 1 1 1 1 Protein tyrosine kinase Glutaredoxin PF00462.19 ESA06202.1 - 0.0034 17.3 2.0 14 5.7 0.0 5.5 6 0 0 6 6 6 1 Glutaredoxin DUF3488 PF11992.3 ESA06202.1 - 0.093 11.3 5.1 13 4.3 0.1 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF3488) CLU_N PF15044.1 ESA06202.1 - 0.22 11.6 8.6 4.4 7.5 0.1 4.9 4 0 0 4 4 4 0 Mitochondrial function, CLU-N-term NUMOD3 PF07460.6 ESA06202.1 - 0.32 10.9 3.9 80 3.2 0.0 5.2 6 0 0 6 6 6 0 NUMOD3 motif (2 copies) DUF2789 PF10982.3 ESA06202.1 - 0.36 10.8 18.2 3.1 7.8 0.1 6.2 6 0 0 6 6 6 0 Protein of unknown function (DUF2789) TraT PF05818.7 ESA06202.1 - 5.6 6.3 12.0 85 2.4 0.0 6.0 7 0 0 7 7 7 0 Enterobacterial TraT complement resistance protein Rtt102p PF09510.5 ESA06203.1 - 0.0052 16.7 0.6 0.0058 16.6 0.4 1.1 1 0 0 1 1 1 1 Rtt102p-like transcription regulator protein DUF4304 PF14137.1 ESA06203.1 - 0.043 13.9 0.1 0.061 13.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4304) YhdB PF14148.1 ESA06203.1 - 0.045 13.5 2.9 0.14 11.9 0.4 2.4 2 1 0 2 2 2 0 YhdB-like protein DUF1949 PF09186.6 ESA06203.1 - 0.047 13.3 0.2 11 5.7 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1949) Clathrin PF00637.15 ESA06203.1 - 0.097 12.2 4.2 7.2 6.1 2.9 2.7 1 1 0 1 1 1 0 Region in Clathrin and VPS DUF3450 PF11932.3 ESA06204.1 - 0.091 12.0 0.5 0.94 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Nucleoporin_C PF03177.9 ESA06207.1 - 0.00015 20.4 0.2 0.00015 20.4 0.1 1.0 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal DUF384 PF04064.8 ESA06207.1 - 0.055 13.0 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF384) Pkinase_Tyr PF07714.12 ESA06208.1 - 2.3e-07 30.1 0.0 0.005 15.9 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase BCS1_N PF08740.6 ESA06208.1 - 0.00042 19.9 0.1 1.2 8.6 0.0 3.0 2 0 0 2 2 2 2 BCS1 N terminal PPARgamma_N PF12577.3 ESA06208.1 - 0.018 15.3 2.1 0.66 10.3 0.1 3.2 3 0 0 3 3 3 0 PPAR gamma N-terminal region Laminin_EGF PF00053.19 ESA06208.1 - 0.1 12.5 1.2 0.22 11.4 0.9 1.4 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) DUF1187 PF06688.6 ESA06209.1 - 0.035 14.2 0.5 0.058 13.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1187) Pkinase_Tyr PF07714.12 ESA06212.1 - 7e-20 71.1 0.0 3.4e-19 68.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06212.1 - 2e-16 59.9 2.2 2e-16 59.9 1.6 2.4 2 1 0 2 2 2 1 Protein kinase domain EAF PF09816.4 ESA06212.1 - 0.038 13.9 0.9 2.6 8.0 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription elongation factor DUF2373 PF10180.4 ESA06212.1 - 1.2 8.7 10.1 9.4 5.8 0.1 3.5 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2373) pKID PF02173.12 ESA06213.1 - 0.31 10.2 4.0 5.6 6.2 0.1 3.2 2 1 1 3 3 3 0 pKID domain Big_5 PF13205.1 ESA06214.1 - 0.0081 16.7 1.9 0.0082 16.7 0.1 1.9 2 0 0 2 2 2 1 Bacterial Ig-like domain Sugar_tr PF00083.19 ESA06215.1 - 9e-128 426.6 21.3 1e-127 426.4 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESA06215.1 - 2.7e-25 88.8 34.3 3.3e-17 62.2 6.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF441 PF04284.8 ESA06215.1 - 0.024 14.5 0.4 0.024 14.5 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF441) TarH PF02203.10 ESA06216.1 - 0.025 14.4 0.8 0.79 9.5 0.4 2.1 1 1 0 1 1 1 0 Tar ligand binding domain homologue DUF3361 PF11841.3 ESA06218.1 - 0.0002 21.0 0.0 0.00023 20.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) DZR PF12773.2 ESA06219.1 - 0.0074 16.0 1.7 0.012 15.4 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF3279 PF11682.3 ESA06219.1 - 0.016 14.7 1.8 0.032 13.8 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) LAP2alpha PF11560.3 ESA06219.1 - 0.03 13.5 0.1 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha DUF3797 PF12677.2 ESA06219.1 - 1.6 8.4 7.6 7.4 6.2 0.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) GnsAB PF08178.6 ESA06221.1 - 1.3 8.7 3.7 4.8 6.9 0.4 2.6 2 1 0 3 3 3 0 GnsA/GnsB family Ras PF00071.17 ESA06223.1 - 4.6e-63 211.4 0.2 5.6e-63 211.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA06223.1 - 1.3e-21 77.2 0.1 2.2e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA06223.1 - 5e-13 48.6 0.1 7.8e-13 48.0 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA06223.1 - 3e-08 33.6 0.1 5.5e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESA06223.1 - 4.3e-06 26.9 0.1 1.2e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 ESA06223.1 - 1.8e-05 24.2 0.1 5.4e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_15 PF13175.1 ESA06223.1 - 0.00015 21.0 0.0 0.0002 20.5 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.7 ESA06223.1 - 0.00018 20.7 0.1 0.00032 19.8 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 ESA06223.1 - 0.0023 17.1 0.0 0.0051 16.0 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 ESA06223.1 - 0.0034 17.2 0.1 0.0084 16.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESA06223.1 - 0.0092 15.2 0.0 0.017 14.3 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 ESA06223.1 - 0.012 15.8 0.1 0.019 15.2 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 ESA06223.1 - 0.021 14.7 0.5 0.055 13.4 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.13 ESA06223.1 - 0.061 12.5 0.1 0.099 11.9 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.1 ESA06223.1 - 0.086 12.4 0.1 0.12 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESA06223.1 - 0.1 12.1 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 ESA06223.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) WD40 PF00400.27 ESA06224.1 - 7.4e-38 127.0 17.9 1.5e-08 34.1 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat Bromodomain PF00439.20 ESA06224.1 - 1e-11 44.5 0.7 2.2e-11 43.4 0.1 2.0 2 0 0 2 2 2 1 Bromodomain Gmad1 PF10647.4 ESA06224.1 - 0.015 14.7 0.2 0.43 9.9 0.1 2.4 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Auxin_resp PF06507.8 ESA06224.1 - 0.016 15.0 0.1 0.054 13.3 0.0 1.9 1 0 0 1 1 1 0 Auxin response factor DnaJ PF00226.26 ESA06225.1 - 1.6e-18 66.1 0.4 2.2e-18 65.7 0.3 1.2 1 0 0 1 1 1 1 DnaJ domain Yip1 PF04893.12 ESA06225.1 - 0.039 13.4 0.1 0.052 13.0 0.1 1.1 1 0 0 1 1 1 0 Yip1 domain zinc-ribbons_6 PF07191.7 ESA06226.1 - 0.00023 20.8 0.2 0.00025 20.7 0.2 1.1 1 0 0 1 1 1 1 zinc-ribbons Plasmodium_Vir PF05795.6 ESA06226.1 - 0.11 11.7 3.7 0.11 11.6 2.6 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein zf-C4_ClpX PF06689.8 ESA06226.1 - 0.26 10.8 2.4 6.4 6.3 0.1 2.3 2 0 0 2 2 2 0 ClpX C4-type zinc finger HMG_box PF00505.14 ESA06227.1 - 6.7e-14 51.9 0.0 7.5e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box Sox_C_TAD PF12067.3 ESA06231.1 - 0.042 14.0 0.1 0.045 13.9 0.0 1.0 1 0 0 1 1 1 0 Sox C-terminal transactivation domain MA3 PF02847.12 ESA06231.1 - 0.15 11.7 0.3 0.2 11.3 0.2 1.5 1 1 0 1 1 1 0 MA3 domain UPF0066 PF01980.11 ESA06233.1 - 0.06 13.3 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0066 Val_tRNA-synt_C PF10458.4 ESA06233.1 - 0.06 13.4 2.6 0.077 13.0 1.6 1.4 1 1 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Phage_1_1 PF08200.6 ESA06233.1 - 1.4 9.1 8.5 1.4 9.1 5.2 1.5 1 1 0 1 1 1 0 Bacteriophage 1.1 Protein HSP70 PF00012.15 ESA06234.1 - 0.0048 14.8 0.0 0.29 9.0 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein UPF0081 PF03652.10 ESA06234.1 - 0.067 13.3 0.0 0.76 9.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0081) MreB_Mbl PF06723.8 ESA06234.1 - 0.085 11.4 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein HSP70 PF00012.15 ESA06235.1 - 0.0018 16.3 0.1 0.35 8.7 0.0 2.4 2 1 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 ESA06235.1 - 0.0098 14.5 0.0 0.18 10.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein StbA PF06406.6 ESA06235.1 - 0.092 11.6 0.2 1.7 7.4 0.0 2.4 1 1 2 3 3 3 0 StbA protein Pkinase_Tyr PF07714.12 ESA06236.1 - 2.8e-05 23.2 2.9 0.079 12.0 0.0 3.5 1 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA06236.1 - 0.04 13.0 12.3 6.4 5.8 8.0 3.6 1 1 1 2 2 2 0 Protein kinase domain TPR_11 PF13414.1 ESA06238.1 - 1.3e-29 101.6 17.0 5e-12 45.3 0.8 3.3 1 1 3 4 4 4 4 TPR repeat TPR_2 PF07719.12 ESA06238.1 - 5.9e-25 85.1 6.2 4.2e-07 29.3 0.1 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESA06238.1 - 5.2e-23 79.6 8.5 6.5e-07 28.6 0.1 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA06238.1 - 1.9e-16 58.5 14.8 4.1e-06 26.1 0.1 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA06238.1 - 4.2e-14 52.2 6.5 2.1e-08 33.9 1.4 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA06238.1 - 2.4e-11 43.9 0.2 3.1e-07 30.8 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA06238.1 - 7.7e-11 41.6 0.0 3.4e-05 23.6 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA06238.1 - 2.3e-10 40.6 0.6 2.7e-06 27.6 0.2 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA06238.1 - 2.6e-10 39.6 5.5 0.0095 16.0 0.0 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA06238.1 - 2.8e-08 33.7 7.7 3.2e-05 23.9 0.2 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESA06238.1 - 4.8e-08 32.9 0.0 0.031 14.9 0.0 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA06238.1 - 5.3e-06 26.5 0.8 2.5 8.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA06238.1 - 7.9e-05 22.1 3.0 0.0088 15.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA06238.1 - 0.00043 19.4 0.6 0.047 12.9 0.1 3.4 4 0 0 4 4 4 1 SHNi-TPR Fis1_TPR_C PF14853.1 ESA06238.1 - 0.00076 19.3 5.1 0.2 11.5 0.0 4.0 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.1 ESA06238.1 - 0.00096 18.2 0.0 0.12 11.4 0.0 2.8 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESA06238.1 - 0.0033 17.4 0.3 0.064 13.3 0.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.5 ESA06238.1 - 0.0057 15.4 0.1 0.12 11.0 0.0 2.1 1 1 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) Glyco_hydro_65m PF03632.10 ESA06238.1 - 0.0064 15.2 0.0 0.016 13.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain TPR_3 PF07720.7 ESA06238.1 - 0.017 14.8 6.7 2.3 8.1 0.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Mrr_cat_2 PF13156.1 ESA06238.1 - 0.028 14.3 0.3 0.05 13.5 0.2 1.4 1 0 0 1 1 1 0 Restriction endonuclease ERG2_Sigma1R PF04622.7 ESA06238.1 - 0.036 13.3 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein TPR_10 PF13374.1 ESA06238.1 - 0.036 13.9 0.7 9.6 6.2 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat Apc5 PF12862.2 ESA06238.1 - 2.8 7.8 8.3 7.1 6.5 0.6 3.5 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF3922 PF13059.1 ESA06238.1 - 8.6 6.6 11.6 11 6.2 1.9 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF3992) TPR_2 PF07719.12 ESA06239.1 - 1.4e-17 62.0 9.5 7.6e-06 25.4 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESA06239.1 - 6.9e-17 60.2 12.5 8.7e-08 31.4 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA06239.1 - 9.9e-16 57.1 9.0 1.3e-11 43.9 2.2 2.9 2 1 1 3 3 3 3 TPR repeat TPR_16 PF13432.1 ESA06239.1 - 2.5e-08 34.3 0.2 1.8e-05 25.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA06239.1 - 5.9e-07 28.8 22.7 0.0018 17.8 0.2 5.7 5 1 1 6 6 6 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA06239.1 - 1.8e-06 27.9 10.8 0.00024 21.1 3.3 2.5 1 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA06239.1 - 1.4e-05 25.2 0.2 1.9 8.9 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA06239.1 - 1.5e-05 24.7 0.1 0.7 9.7 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA06239.1 - 4.3e-05 23.3 8.6 0.32 11.3 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA06239.1 - 6.8e-05 23.1 0.0 5.4 7.9 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA06239.1 - 0.00064 20.0 2.6 2.5 8.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA06239.1 - 0.0015 18.3 10.3 0.052 13.4 2.0 3.5 3 1 1 4 4 4 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA06239.1 - 0.13 12.1 6.7 1.5 8.7 0.2 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat COX4 PF02936.9 ESA06240.1 - 1.2e-33 115.8 0.2 1.4e-33 115.6 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV N1221 PF07923.8 ESA06240.1 - 0.059 12.2 0.1 0.093 11.5 0.0 1.3 1 1 0 1 1 1 0 N1221-like protein DUF3106 PF11304.3 ESA06240.1 - 0.064 13.6 2.6 0.096 13.1 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) Unstab_antitox PF09720.5 ESA06240.1 - 0.23 11.1 2.9 0.24 11.1 0.1 2.2 2 1 0 2 2 2 0 Putative addiction module component DUF1289 PF06945.8 ESA06240.1 - 3.9 7.0 6.3 1.2 8.6 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1289) SUR7 PF06687.7 ESA06241.1 - 0.022 14.3 0.1 0.033 13.7 0.1 1.3 1 0 0 1 1 1 0 SUR7/PalI family DUF1751 PF08551.5 ESA06241.1 - 0.059 13.7 5.9 0.085 13.1 4.1 1.3 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) DUF3054 PF11255.3 ESA06241.1 - 0.071 12.9 2.4 0.065 13.0 0.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) 7TMR-DISM_7TM PF07695.6 ESA06241.1 - 0.11 12.1 9.1 0.14 11.7 6.3 1.2 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF4293 PF14126.1 ESA06241.1 - 0.13 12.2 7.8 0.1 12.5 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) MacB_PCD PF12704.2 ESA06241.1 - 0.41 10.2 0.0 0.41 10.2 0.0 2.3 2 1 1 3 3 3 0 MacB-like periplasmic core domain Tetraspannin PF00335.15 ESA06241.1 - 0.5 9.6 5.4 0.98 8.6 3.7 1.6 1 1 0 1 1 1 0 Tetraspanin family CD47 PF04549.9 ESA06241.1 - 1.3 9.0 11.5 4.9 7.1 4.7 2.1 1 1 1 2 2 2 0 CD47 transmembrane region MFS_Mycoplasma PF07672.8 ESA06241.1 - 2.7 7.0 9.6 10 5.1 6.7 1.8 1 1 0 1 1 1 0 Mycoplasma MFS transporter DUF4064 PF13273.1 ESA06241.1 - 4.7 7.3 9.9 9.6 6.3 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Fer4_9 PF13187.1 ESA06242.1 - 0.011 15.9 1.3 5.5 7.3 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain BACK PF07707.10 ESA06242.1 - 0.071 12.9 0.1 1.5 8.6 0.0 2.6 2 0 0 2 2 2 0 BTB And C-terminal Kelch Thioredoxin_3 PF13192.1 ESA06242.1 - 0.097 12.4 0.8 8.6 6.2 0.1 2.7 2 0 0 2 2 2 0 Thioredoxin domain Tat PF00539.13 ESA06242.1 - 2.3 7.9 9.1 4.2 7.0 0.4 2.5 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) zf-H2C2_5 PF13909.1 ESA06242.1 - 9.5 6.6 15.8 13 6.2 3.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF3447 PF11929.3 ESA06243.1 - 0.072 12.9 0.9 0.17 11.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) NYD-SP28 PF14772.1 ESA06243.1 - 0.14 12.2 0.5 0.28 11.3 0.3 1.4 1 0 0 1 1 1 0 Sperm tail MFS_1 PF07690.11 ESA06245.1 - 1.2e-42 145.9 27.2 1.2e-42 145.9 18.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA06245.1 - 4.1e-09 35.5 9.9 4.1e-09 35.5 6.9 4.1 3 1 1 4 4 4 3 Sugar (and other) transporter MFS_3 PF05977.8 ESA06245.1 - 0.00014 20.1 1.4 0.00023 19.4 1.0 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector DUF2140 PF09911.4 ESA06245.1 - 0.25 10.5 2.0 12 4.9 0.4 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) Tricorn_C1 PF14684.1 ESA06246.1 - 0.029 14.2 2.0 0.044 13.6 0.8 1.8 1 1 1 2 2 2 0 Tricorn protease C1 domain DASH_Duo1 PF08651.5 ESA06246.1 - 0.039 13.5 0.2 0.13 11.8 0.1 2.0 2 1 0 2 2 2 0 DASH complex subunit Duo1 BNR PF02012.15 ESA06247.1 - 8.9e-07 27.8 16.5 0.67 10.0 0.1 5.9 6 0 0 6 6 6 4 BNR/Asp-box repeat BNR_2 PF13088.1 ESA06247.1 - 0.0037 16.5 0.2 9.2 5.4 0.0 3.9 2 1 1 3 3 3 2 BNR repeat-like domain CHB_HEX_C_1 PF13290.1 ESA06247.1 - 0.14 11.9 0.4 20 5.0 0.1 2.8 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain zf-FCS PF06467.9 ESA06248.1 - 0.11 12.1 2.6 0.22 11.1 1.8 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DBP10CT PF08147.7 ESA06250.1 - 0.046 13.5 0.1 0.063 13.1 0.1 1.2 1 0 0 1 1 1 0 DBP10CT (NUC160) domain SPA PF08616.5 ESA06251.1 - 0.042 13.5 0.2 0.07 12.8 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis DUF3603 PF12227.3 ESA06251.1 - 0.18 10.8 3.1 2.3 7.2 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3603) BACK PF07707.10 ESA06255.1 - 2.1e-05 24.2 1.8 0.00021 21.0 1.0 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch Med27 PF11571.3 ESA06255.1 - 0.16 12.0 0.7 5.4 7.2 0.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 27 MFS_1 PF07690.11 ESA06256.1 - 8.6e-23 80.6 5.8 8.6e-23 80.6 4.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA06256.1 - 0.005 15.4 8.6 0.0074 14.9 5.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_3 PF05977.8 ESA06256.1 - 0.0055 14.8 0.2 0.0068 14.5 0.1 1.1 1 0 0 1 1 1 1 Transmembrane secretion effector DUF1275 PF06912.6 ESA06256.1 - 0.015 14.5 2.5 0.021 14.0 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) Myco_arth_vir_N PF09610.5 ESA06256.1 - 0.072 13.0 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) ATG22 PF11700.3 ESA06256.1 - 0.099 11.0 4.4 0.13 10.7 3.1 1.2 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like TSC22 PF01166.13 ESA06257.1 - 0.0046 16.8 18.9 0.013 15.4 1.3 3.8 3 0 0 3 3 3 2 TSC-22/dip/bun family Cas_DxTHG PF09455.5 ESA06257.1 - 0.46 9.5 13.0 0.53 9.3 9.0 1.2 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Rootletin PF15035.1 ESA06257.1 - 0.49 10.3 40.2 0.24 11.3 6.6 3.2 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion NPV_P10 PF05531.7 ESA06257.1 - 0.94 9.7 13.7 13 6.1 0.8 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 ESA06257.1 - 1.3 8.5 41.6 0.28 10.7 18.4 2.5 1 1 1 2 2 2 0 IncA protein Sec2p PF06428.6 ESA06257.1 - 1.5 8.7 30.9 0.043 13.6 4.8 3.8 1 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF948 PF06103.6 ESA06257.1 - 1.6 8.6 13.2 0.46 10.3 1.5 3.2 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF904 PF06005.7 ESA06257.1 - 1.9 8.8 42.5 5.6 7.3 4.3 4.4 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Tropomyosin PF00261.15 ESA06257.1 - 2 7.4 42.3 13 4.7 18.9 2.3 1 1 1 2 2 2 0 Tropomyosin DUF3138 PF11336.3 ESA06257.1 - 2.6 6.1 6.2 1.8 6.6 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) V_ATPase_I PF01496.14 ESA06257.1 - 9.5 3.9 28.1 34 2.0 5.9 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Fungal_trans PF04082.13 ESA06259.1 - 1.6e-12 46.8 0.0 1.6e-12 46.8 0.0 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain LCD1 PF09798.4 ESA06259.1 - 0.002 16.2 10.7 0.002 16.2 7.4 1.8 2 0 0 2 2 2 1 DNA damage checkpoint protein PAT1 PF09770.4 ESA06259.1 - 0.3 9.2 33.1 0.43 8.7 22.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprT-like PF10263.4 ESA06260.1 - 0.15 11.6 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 SprT-like family HSBP1 PF06825.7 ESA06261.1 - 0.1 12.1 0.6 4.7 6.8 0.3 2.1 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF328 PF03883.9 ESA06266.1 - 0.0022 17.3 0.1 0.0033 16.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF328) zf-CCHC_6 PF15288.1 ESA06266.1 - 0.084 12.5 1.5 0.17 11.5 1.0 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF3837 PF12939.2 ESA06266.1 - 0.13 12.2 1.4 0.23 11.4 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) SMI1_KNR4 PF09346.5 ESA06266.1 - 0.21 11.6 1.9 0.41 10.6 1.3 1.4 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) PPR_2 PF13041.1 ESA06270.1 - 7.5e-11 41.8 0.1 0.0023 17.8 0.0 3.2 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.1 ESA06270.1 - 1.5e-07 31.1 0.0 0.0035 17.4 0.0 3.0 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.15 ESA06270.1 - 1.4e-06 27.8 0.2 0.067 13.2 0.1 2.9 3 0 0 3 3 3 2 PPR repeat PPR_1 PF12854.2 ESA06270.1 - 0.018 14.4 0.6 0.063 12.7 0.1 2.1 2 0 0 2 2 2 0 PPR repeat SRI PF08236.6 ESA06271.1 - 2.5e-09 36.9 0.8 2.9e-09 36.7 0.4 1.2 1 1 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain NodS PF05401.6 ESA06271.1 - 0.067 12.5 0.0 0.072 12.4 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) Neuromodulin_N PF10580.4 ESA06272.1 - 0.18 11.4 1.2 0.34 10.5 0.9 1.4 1 0 0 1 1 1 0 Gap junction protein N-terminal region TRAP_alpha PF03896.11 ESA06275.1 - 5.7 5.8 9.6 5.8 5.8 6.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ApoLp-III PF07464.6 ESA06281.1 - 0.0098 15.9 1.8 0.013 15.4 1.3 1.1 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) M PF02370.11 ESA06281.1 - 0.13 12.6 1.3 0.36 11.3 0.9 1.7 1 0 0 1 1 1 0 M protein repeat DUF4342 PF14242.1 ESA06281.1 - 0.16 11.7 2.7 0.17 11.7 1.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4342) Helitron_like_N PF14214.1 ESA06282.1 - 1e-42 145.9 0.4 2.2e-42 144.8 0.1 1.8 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus Pkinase_Tyr PF07714.12 ESA06284.1 - 8.2e-32 110.2 0.0 4.5e-28 98.0 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA06284.1 - 3.9e-28 98.3 0.0 2.8e-27 95.4 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain SLIDE PF09111.5 ESA06286.1 - 0.11 12.2 0.6 0.12 12.1 0.4 1.1 1 0 0 1 1 1 0 SLIDE ApoB100_C PF12491.3 ESA06286.1 - 0.13 11.9 0.3 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 Apolipoprotein B100 C terminal Methyltransf_25 PF13649.1 ESA06287.1 - 3.3e-13 49.8 0.0 6.7e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA06287.1 - 5.6e-13 49.1 0.0 1.2e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06287.1 - 5.6e-12 45.5 0.1 2.8e-11 43.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA06287.1 - 1.8e-09 37.5 0.0 2.5e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA06287.1 - 8.6e-08 32.7 0.0 2.3e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA06287.1 - 7e-07 29.6 0.0 1.4e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA06287.1 - 1.9e-06 27.0 0.0 3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 ESA06287.1 - 2.4e-05 23.5 0.0 9.8e-05 21.5 0.0 1.9 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ESA06287.1 - 3.3e-05 23.3 0.0 5.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA06287.1 - 9.3e-05 22.4 0.0 0.00016 21.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA06287.1 - 0.0023 17.9 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_9 PF08003.6 ESA06287.1 - 0.0049 15.6 0.0 0.0085 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.8 ESA06287.1 - 0.0051 15.9 0.0 0.0095 15.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 ESA06287.1 - 0.016 14.5 0.0 0.046 13.0 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase small domain Methyltransf_8 PF05148.10 ESA06287.1 - 0.025 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase TehB PF03848.9 ESA06287.1 - 0.025 13.7 0.2 0.09 11.9 0.1 1.8 1 1 0 1 1 1 0 Tellurite resistance protein TehB DnaB_2 PF07261.6 ESA06287.1 - 0.24 11.0 2.1 14 5.3 0.0 2.9 3 0 0 3 3 3 0 Replication initiation and membrane attachment BTB PF00651.26 ESA06288.1 - 3.4e-19 68.8 0.1 8.6e-19 67.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA06288.1 - 6.7e-15 55.3 1.7 6.7e-15 55.3 1.1 2.5 4 0 0 4 4 4 1 TLD BACK PF07707.10 ESA06288.1 - 4.3e-05 23.3 4.7 0.00017 21.3 0.5 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF976 PF06162.7 ESA06288.1 - 0.13 11.7 0.7 2.3 7.6 0.1 2.6 3 0 0 3 3 3 0 Caenorhabditis elegans protein of unknown function (DUF976) TLD PF07534.11 ESA06289.1 - 5.9e-14 52.2 1.6 1.4e-13 51.0 1.1 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA06289.1 - 1.6e-13 50.5 0.3 4.1e-13 49.2 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA06289.1 - 0.00055 19.7 5.6 0.0015 18.3 0.7 3.7 3 1 1 4 4 4 1 BTB And C-terminal Kelch HMG_box PF00505.14 ESA06290.1 - 2.7e-07 30.7 0.6 5.1e-07 29.8 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06290.1 - 0.00049 20.3 1.0 0.00081 19.7 0.5 1.5 1 1 0 1 1 1 1 HMG-box domain Atg14 PF10186.4 ESA06290.1 - 0.039 12.9 0.8 0.042 12.7 0.6 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Vpu PF00558.14 ESA06290.1 - 0.83 9.2 3.0 1.1 8.8 1.7 1.4 1 1 0 1 1 1 0 Vpu protein Pkinase PF00069.20 ESA06291.1 - 1.5e-29 102.9 0.6 3e-29 101.9 0.4 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06291.1 - 7.6e-29 100.5 0.1 1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PSD3 PF07626.6 ESA06292.1 - 0.18 11.8 1.2 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1587) bZIP_1 PF00170.16 ESA06292.1 - 9.5 6.2 8.8 1.7 8.6 1.0 2.8 3 0 0 3 3 3 0 bZIP transcription factor DUF496 PF04363.7 ESA06293.1 - 0.14 11.9 7.4 0.13 12.0 3.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF496) Rad60-SLD PF11976.3 ESA06294.1 - 3.1e-19 68.4 0.0 3.8e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESA06294.1 - 5.3e-08 32.1 0.0 6.3e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Pkinase_Tyr PF07714.12 ESA06295.1 - 2.4e-29 102.1 1.4 9.4e-20 70.7 0.1 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA06295.1 - 4e-25 88.4 0.9 4e-25 88.4 0.6 1.9 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA06295.1 - 7.7e-08 32.7 17.8 0.00013 22.4 0.1 4.0 5 0 0 5 5 5 2 Sel1 repeat TPR_19 PF14559.1 ESA06295.1 - 0.0024 18.1 5.0 0.03 14.6 0.2 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA06295.1 - 0.026 14.7 0.3 0.15 12.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Hrs_helical PF12210.3 ESA06295.1 - 0.037 14.2 0.1 0.17 12.1 0.1 2.2 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate TPR_11 PF13414.1 ESA06295.1 - 1 9.0 13.2 0.15 11.7 0.3 3.4 1 1 2 3 3 3 0 TPR repeat TPR_6 PF13174.1 ESA06295.1 - 1.4 9.5 8.9 7.2 7.3 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA06295.1 - 1.7 9.3 8.6 12 6.7 0.7 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat AAA PF00004.24 ESA06296.1 - 2.1e-45 154.1 0.2 1.1e-35 122.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA06296.1 - 5.4e-07 29.4 0.0 7.9e-05 22.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESA06296.1 - 1.7e-06 28.8 0.1 0.0039 18.0 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.9 ESA06296.1 - 1e-05 25.5 0.0 0.023 14.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESA06296.1 - 2.9e-05 24.2 0.3 0.27 11.4 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESA06296.1 - 6.9e-05 22.7 0.1 0.32 10.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 ESA06296.1 - 0.00013 21.7 1.6 0.023 14.4 0.0 3.4 2 1 0 3 3 3 1 Archaeal ATPase DUF815 PF05673.8 ESA06296.1 - 0.00026 20.0 0.0 0.56 9.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_16 PF13191.1 ESA06296.1 - 0.00028 20.9 0.0 0.047 13.6 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 ESA06296.1 - 0.00043 20.6 0.0 0.018 15.3 0.0 2.6 2 0 0 2 2 2 1 ABC transporter Miro PF08477.8 ESA06296.1 - 0.00081 19.8 1.8 0.4 11.1 0.0 4.1 3 2 2 5 5 5 1 Miro-like protein NACHT PF05729.7 ESA06296.1 - 0.0038 16.8 0.2 0.2 11.3 0.0 3.0 3 0 0 3 3 3 1 NACHT domain MobB PF03205.9 ESA06296.1 - 0.0051 16.5 0.3 0.07 12.8 0.0 2.8 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 ESA06296.1 - 0.0065 15.9 0.2 1.1 8.6 0.0 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 ESA06296.1 - 0.0073 16.1 0.0 0.31 10.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA06296.1 - 0.01 14.9 0.0 0.16 11.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.1 ESA06296.1 - 0.026 14.8 1.7 0.22 11.7 0.0 3.1 3 2 1 4 4 4 0 AAA domain ATP-synt_ab PF00006.20 ESA06296.1 - 0.027 13.9 0.1 0.7 9.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RuvB_N PF05496.7 ESA06296.1 - 0.032 13.2 0.0 5.6 5.9 0.0 2.7 3 0 0 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 ESA06296.1 - 0.035 14.2 0.5 2.9 8.1 0.1 2.8 2 1 0 2 2 2 0 RNA helicase Guanylate_kin PF00625.16 ESA06296.1 - 0.041 13.3 0.2 0.35 10.2 0.0 2.5 2 1 0 2 2 2 0 Guanylate kinase AAA_11 PF13086.1 ESA06296.1 - 0.068 12.7 0.8 0.16 11.5 0.5 2.0 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESA06296.1 - 0.11 11.7 0.7 0.46 9.6 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function, DUF258 SMC_N PF02463.14 ESA06296.1 - 0.15 11.2 0.0 0.44 9.7 0.0 1.9 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain OEP PF02321.13 ESA06297.1 - 0.028 14.0 0.2 0.04 13.5 0.1 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein TBP PF00352.16 ESA06297.1 - 0.048 13.0 0.2 0.11 11.9 0.1 1.7 1 1 0 1 1 1 0 Transcription factor TFIID (or TATA-binding protein, TBP) TAFII28 PF04719.9 ESA06297.1 - 0.073 12.8 5.0 5 6.9 0.1 3.7 3 1 1 4 4 4 0 hTAFII28-like protein conserved region Pkinase PF00069.20 ESA06298.1 - 2.3e-13 49.8 0.4 2.3e-13 49.8 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06298.1 - 3.3e-11 42.7 0.1 3.3e-11 42.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA06298.1 - 0.012 14.7 0.1 0.012 14.7 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA06299.1 - 6.9e-21 74.4 0.0 9.9e-21 73.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06299.1 - 5.8e-20 71.5 0.1 8.4e-20 71.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF896 PF05979.7 ESA06299.1 - 0.018 14.6 0.3 0.052 13.1 0.2 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) RecR PF02132.10 ESA06299.1 - 0.2 11.1 2.0 0.42 10.1 1.4 1.5 1 0 0 1 1 1 0 RecR protein Pkinase_Tyr PF07714.12 ESA06300.1 - 6.8e-11 41.7 0.0 7.7e-11 41.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06300.1 - 1.6e-08 34.0 0.0 1.9e-08 33.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain SLBP_RNA_bind PF15247.1 ESA06300.1 - 0.086 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Histone RNA hairpin-binding protein RNA-binding domain Rib PF08428.5 ESA06301.1 - 0.013 15.2 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Rib/alpha-like repeat Endonuc-dimeris PF09124.5 ESA06303.1 - 0.012 15.1 0.1 0.025 14.1 0.1 1.4 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation FCH PF00611.18 ESA06303.1 - 0.076 13.2 0.4 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Lipase_3 PF01764.20 ESA06304.1 - 7.1e-21 74.3 0.0 1.3e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA06304.1 - 0.0056 16.4 0.0 0.0095 15.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF659 PF04937.10 ESA06305.1 - 7.4e-08 32.0 0.5 1.4e-07 31.1 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Cauli_DNA-bind PF03310.8 ESA06305.1 - 0.12 12.2 0.4 0.21 11.4 0.3 1.3 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Pkinase PF00069.20 ESA06306.1 - 3.8e-30 104.9 0.3 1.1e-29 103.3 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06306.1 - 2.8e-15 56.1 0.0 2e-09 36.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESA06306.1 - 1.3e-05 24.3 0.0 2.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA06306.1 - 0.034 13.5 0.1 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Latarcin PF10279.4 ESA06306.1 - 0.052 13.7 0.7 0.41 10.8 0.0 2.7 3 0 0 3 3 3 0 Latarcin precursor PIN_4 PF13638.1 ESA06310.1 - 5.9e-29 100.8 0.3 5.9e-29 100.8 0.2 2.1 2 0 0 2 2 2 1 PIN domain OSTbeta PF15048.1 ESA06312.1 - 0.0092 16.0 0.8 0.0096 15.9 0.5 1.1 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein MIF4G PF02854.14 ESA06313.1 - 2.4e-39 134.9 14.1 4.6e-39 134.0 9.8 1.5 1 0 0 1 1 1 1 MIF4G domain DUF3592 PF12158.3 ESA06315.1 - 0.2 11.4 16.9 0.66 9.7 11.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3592) Imm22 PF15592.1 ESA06316.1 - 0.0076 16.5 1.2 0.011 16.0 0.5 1.6 1 1 0 1 1 1 1 Immunity protein 22 CDC37_N PF03234.9 ESA06316.1 - 0.013 15.8 7.2 0.014 15.7 5.0 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF964 PF06133.6 ESA06316.1 - 0.021 14.8 5.6 0.023 14.6 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF964) RRF_GI PF12614.3 ESA06316.1 - 0.027 14.2 3.5 0.032 14.0 2.4 1.0 1 0 0 1 1 1 0 Ribosome recycling factor DUF2450 PF10475.4 ESA06316.1 - 0.066 12.1 3.6 0.069 12.0 2.5 1.0 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) YopJ PF03421.11 ESA06316.1 - 0.11 12.3 1.9 0.13 12.0 1.3 1.1 1 0 0 1 1 1 0 YopJ Serine/Threonine acetyltransferase RIO1 PF01163.17 ESA06316.1 - 0.15 11.3 2.6 0.17 11.2 1.8 1.1 1 0 0 1 1 1 0 RIO1 family DUF2458 PF10454.4 ESA06316.1 - 0.29 10.9 7.7 0.64 9.9 5.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) GvpG PF05120.7 ESA06316.1 - 0.38 10.5 9.0 0.16 11.8 0.7 2.1 1 1 1 2 2 2 0 Gas vesicle protein G TBCA PF02970.11 ESA06316.1 - 0.46 10.5 8.9 3.3 7.8 6.1 2.0 1 1 0 1 1 1 0 Tubulin binding cofactor A NPV_P10 PF05531.7 ESA06316.1 - 0.56 10.4 3.7 1 9.6 2.3 1.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1002 PF06207.6 ESA06316.1 - 0.61 9.3 4.4 0.71 9.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) AHH PF14412.1 ESA06316.1 - 0.63 10.0 4.0 2.6 8.0 2.8 1.9 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF677 PF05055.7 ESA06316.1 - 0.72 8.4 9.2 0.72 8.4 6.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF677) EMP24_GP25L PF01105.19 ESA06316.1 - 0.74 9.5 3.7 0.79 9.4 2.5 1.2 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD HSBP1 PF06825.7 ESA06316.1 - 0.91 9.1 7.5 5.8 6.5 5.2 2.2 1 1 0 1 1 1 0 Heat shock factor binding protein 1 Cauli_AT PF03233.8 ESA06316.1 - 2.7 7.6 8.4 3 7.5 5.8 1.1 1 0 0 1 1 1 0 Aphid transmission protein DMPK_coil PF08826.5 ESA06316.1 - 4.6 7.2 12.2 5.5 6.9 0.4 2.4 2 1 0 2 2 2 0 DMPK coiled coil domain like AAA_23 PF13476.1 ESA06316.1 - 6.5 7.0 14.2 7.8 6.7 9.8 1.1 1 0 0 1 1 1 0 AAA domain DUF919 PF06034.6 ESA06316.1 - 7.8 6.2 13.0 0.41 10.2 3.4 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF3788 PF12663.2 ESA06317.1 - 0.049 13.3 1.0 0.07 12.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) Myb_DNA-bind_2 PF08914.6 ESA06318.1 - 3.3e-10 39.6 0.4 8.3e-09 35.1 0.0 2.7 2 0 0 2 2 2 1 Rap1 Myb domain Rap1_C PF11626.3 ESA06318.1 - 1.8e-06 27.7 0.1 7.1e-06 25.8 0.0 2.1 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Rap1-DNA-bind PF09197.5 ESA06318.1 - 3.8e-06 27.3 0.1 3.8e-06 27.3 0.1 2.9 3 1 0 3 3 3 1 Rap1, DNA-binding Cir_Bir_Yir PF06022.6 ESA06320.1 - 0.45 9.6 4.9 0.062 12.5 0.6 1.5 2 0 0 2 2 2 0 Plasmodium variant antigen protein Cir/Yir/Bir RRM_1 PF00076.17 ESA06322.1 - 1.3e-10 40.6 0.5 5.6e-10 38.7 0.1 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA06322.1 - 9.1e-10 38.2 0.0 2.2e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA06322.1 - 1.9e-05 24.5 0.1 5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA06322.1 - 0.00075 19.2 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif ImmE5 PF11480.3 ESA06323.1 - 6.5 6.6 6.5 24 4.8 0.0 2.3 1 1 1 2 2 2 0 Colicin-E5 Imm protein DKCLD PF08068.7 ESA06325.1 - 6.9e-31 105.9 1.2 5.8e-30 103.0 0.1 2.8 4 0 0 4 4 4 1 DKCLD (NUC011) domain TruB_N PF01509.13 ESA06325.1 - 1.8e-24 86.6 0.1 1.4e-21 77.2 0.1 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 ESA06325.1 - 3.2e-20 71.6 1.5 5.8e-20 70.8 1.0 1.4 1 0 0 1 1 1 1 PUA domain PPR_2 PF13041.1 ESA06326.1 - 1.4e-56 188.2 19.9 1.5e-15 56.9 0.4 7.4 5 1 4 9 9 9 6 PPR repeat family PPR PF01535.15 ESA06326.1 - 6.3e-41 135.5 11.4 3.4e-09 36.0 0.0 8.6 9 0 0 9 9 9 7 PPR repeat PPR_3 PF13812.1 ESA06326.1 - 8.6e-39 128.5 0.2 9.9e-09 34.8 0.0 8.0 9 0 0 9 9 7 7 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA06326.1 - 8.8e-38 127.4 0.7 1.2e-09 37.4 0.0 7.4 7 0 0 7 7 7 6 PPR repeat TPR_19 PF14559.1 ESA06326.1 - 4.6e-08 33.2 0.0 0.0041 17.4 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat MRP-S27 PF10037.4 ESA06326.1 - 6.6e-05 22.0 6.3 0.0066 15.4 0.1 3.2 2 1 1 3 3 3 2 Mitochondrial 28S ribosomal protein S27 TPR_7 PF13176.1 ESA06326.1 - 0.0072 16.0 0.0 1.5 8.8 0.0 4.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA06326.1 - 0.011 16.4 0.0 7.6 7.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA06326.1 - 0.012 15.2 0.2 3 7.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA06326.1 - 0.077 12.9 4.1 3.9 7.4 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.15 ESA06326.1 - 0.12 11.9 13.3 0.3 10.6 0.0 5.1 4 2 1 5 5 5 0 Region in Clathrin and VPS TPR_6 PF13174.1 ESA06326.1 - 0.2 12.2 7.9 44 4.8 0.0 5.4 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA06326.1 - 0.67 9.8 0.1 0.67 9.8 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DDE_1 PF03184.14 ESA06327.1 - 2e-10 40.2 0.1 2.4e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease NAGLU PF05089.7 ESA06327.1 - 0.039 12.7 0.0 0.045 12.5 0.0 1.0 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain LRR_8 PF13855.1 ESA06328.1 - 1.5e-16 59.8 14.5 6.7e-08 32.1 6.8 4.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.2 ESA06328.1 - 1.5e-14 53.2 23.0 3.7e-07 29.5 0.2 6.0 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA06328.1 - 3.3e-07 29.4 18.2 1.5 9.1 0.7 7.4 6 1 0 6 6 6 4 Leucine Rich Repeat LRR_7 PF13504.1 ESA06328.1 - 0.0042 17.0 12.2 5.1 7.7 0.1 6.2 6 0 0 6 6 6 2 Leucine rich repeat LRR_9 PF14580.1 ESA06328.1 - 0.0071 15.9 1.0 0.017 14.6 0.7 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.1 ESA06328.1 - 0.029 14.4 19.3 0.48 10.6 0.7 6.2 6 0 0 6 6 6 0 Leucine Rich repeat DUF3635 PF12330.3 ESA06329.1 - 1.1e-20 73.5 0.3 4.6e-20 71.5 0.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3635) DUF4112 PF13430.1 ESA06330.1 - 1.9e-26 92.0 1.3 2.3e-26 91.7 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Delta_lysin PF05372.6 ESA06330.1 - 0.012 14.9 0.3 0.025 13.9 0.2 1.5 1 0 0 1 1 1 0 Delta lysin family Metallophos PF00149.23 ESA06331.1 - 7e-11 41.8 4.9 1.6e-10 40.7 3.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FA_hydroxylase PF04116.8 ESA06332.1 - 1.4e-15 57.6 21.1 1.4e-15 57.6 14.6 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Ribosomal_L2_C PF03947.13 ESA06333.1 - 1.7e-42 144.2 3.4 2.5e-42 143.7 2.4 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESA06333.1 - 1.4e-16 60.1 0.0 3.3e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain BPL_LplA_LipB PF03099.14 ESA06334.1 - 4.4e-21 75.1 0.0 8.1e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Lip_prot_lig_C PF10437.4 ESA06334.1 - 2.2e-09 36.8 0.1 4.9e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus Tcf25 PF04910.9 ESA06334.1 - 0.055 12.4 0.1 5.9 5.7 0.0 2.1 2 0 0 2 2 2 0 Transcriptional repressor TCF25 PPR_2 PF13041.1 ESA06335.1 - 3e-34 116.7 14.1 9.2e-09 35.1 0.2 6.4 3 1 3 6 6 6 6 PPR repeat family PPR PF01535.15 ESA06335.1 - 9.3e-21 72.3 10.0 0.0005 19.8 0.0 8.3 8 1 0 8 8 8 5 PPR repeat PPR_3 PF13812.1 ESA06335.1 - 6.9e-18 63.3 0.1 0.005 17.0 0.0 6.6 6 0 0 6 6 6 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA06335.1 - 1.4e-14 53.2 2.8 0.0015 17.9 0.0 6.5 7 0 0 7 7 7 3 PPR repeat TPR_19 PF14559.1 ESA06335.1 - 2.8e-07 30.7 1.1 0.37 11.1 0.0 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat ECSIT PF06239.6 ESA06335.1 - 0.00012 21.0 0.2 0.0028 16.5 0.1 2.8 2 1 0 2 2 2 1 Evolutionarily conserved signalling intermediate in Toll pathway SPOB_a PF14689.1 ESA06335.1 - 0.00049 19.5 4.9 1.4 8.5 0.1 4.2 4 0 0 4 4 4 1 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_14 PF13428.1 ESA06335.1 - 0.0016 18.8 0.0 27 5.7 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA06335.1 - 0.0017 17.9 3.8 0.017 14.8 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.15 ESA06335.1 - 0.017 14.6 14.0 2.8 7.5 0.6 4.1 2 1 2 4 4 4 0 Region in Clathrin and VPS TPR_16 PF13432.1 ESA06335.1 - 0.037 14.7 0.1 7 7.4 0.1 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA06335.1 - 0.22 11.5 5.0 26 5.0 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat LUC7 PF03194.10 ESA06335.1 - 1.3 8.5 5.8 1.2 8.6 0.2 2.3 1 1 1 2 2 2 0 LUC7 N_terminus Pkinase PF00069.20 ESA06339.1 - 3.2e-05 23.2 0.1 0.00019 20.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06339.1 - 0.054 12.5 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Histone PF00125.19 ESA06340.1 - 2.6e-23 81.9 0.0 3.5e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA06340.1 - 0.00018 21.5 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DLIC PF05783.6 ESA06340.1 - 0.093 11.3 0.4 0.12 11.0 0.3 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Colicin PF01024.14 ESA06342.1 - 0.0041 16.7 0.0 0.0041 16.7 0.0 1.7 2 0 0 2 2 2 1 Colicin pore forming domain zf-CCHC PF00098.18 ESA06344.1 - 0.00057 19.6 3.0 0.00083 19.1 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA06344.1 - 0.0097 15.3 0.4 0.02 14.3 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF1031 PF06275.6 ESA06344.1 - 0.047 13.7 0.2 0.089 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1031) eIF3g PF12353.3 ESA06344.1 - 0.21 11.4 5.4 0.33 10.8 3.1 2.0 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_4 PF14392.1 ESA06344.1 - 0.51 10.0 2.2 1.2 8.8 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle DUF3883 PF13020.1 ESA06345.1 - 3.5 7.4 6.0 7.4 6.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3883) HAUS4 PF14735.1 ESA06346.1 - 7.4e-19 67.9 6.7 8.6e-19 67.7 4.7 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Poxvirus PF06227.7 ESA06346.1 - 0.019 14.5 2.8 0.028 13.9 2.0 1.3 1 0 0 1 1 1 0 dsDNA Poxvirus DUF234 PF03008.9 ESA06346.1 - 0.054 13.6 0.5 0.054 13.6 0.3 1.7 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function OGG_N PF07934.7 ESA06346.1 - 0.12 12.2 1.5 0.21 11.5 1.0 1.6 1 1 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain Corona_S2 PF01601.11 ESA06346.1 - 0.13 10.3 2.8 0.14 10.1 2.0 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF1664 PF07889.7 ESA06346.1 - 0.3 10.9 2.9 0.42 10.4 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.8 ESA06346.1 - 1.2 9.9 5.8 8.5 7.1 0.1 2.4 1 1 0 2 2 2 0 Occludin homology domain Tbf5 PF06331.7 ESA06347.1 - 2.7e-23 81.5 3.5 3e-23 81.3 2.4 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 DUF1436 PF07262.6 ESA06347.1 - 0.089 12.2 0.4 0.097 12.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) UCH PF00443.24 ESA06348.1 - 1.6e-18 66.7 0.1 2.1e-18 66.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA06348.1 - 3.4e-15 56.2 0.0 5.5e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase LRR_4 PF12799.2 ESA06349.1 - 0.073 12.7 13.0 0.26 10.9 0.6 4.3 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) ThiF PF00899.16 ESA06350.1 - 0.11 12.3 0.1 0.6 9.9 0.0 2.1 2 0 0 2 2 2 0 ThiF family HMG_box PF00505.14 ESA06352.1 - 0.00041 20.5 1.6 0.001 19.3 1.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box DUF2483 PF10656.4 ESA06352.1 - 0.013 15.5 0.0 0.013 15.5 0.0 2.3 3 0 0 3 3 3 0 Hypothetical protein of unknown function (DUF2483) ABC_membrane_2 PF06472.10 ESA06353.1 - 1.7e-85 286.5 0.4 2.4e-85 286.0 0.1 1.3 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 DUF1730 PF08331.5 ESA06353.1 - 0.033 13.8 0.4 0.097 12.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) GATA PF00320.22 ESA06354.1 - 1e-12 47.1 3.7 2e-12 46.2 2.5 1.4 1 0 0 1 1 1 1 GATA zinc finger DUF605 PF04652.11 ESA06354.1 - 10 5.4 12.2 13 5.0 8.5 1.1 1 0 0 1 1 1 0 Vta1 like TFIIA PF03153.8 ESA06355.1 - 2 8.2 18.9 2.4 7.9 13.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Homeobox_KN PF05920.6 ESA06356.1 - 6.8e-18 64.0 0.8 1.4e-17 63.1 0.6 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 ESA06356.1 - 2.2e-08 33.5 1.0 5.6e-08 32.2 0.2 2.0 2 0 0 2 2 2 1 Homeobox domain Homez PF11569.3 ESA06356.1 - 0.034 13.2 0.2 0.097 11.7 0.1 1.9 1 1 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Pkinase PF00069.20 ESA06357.1 - 0.043 12.9 0.0 0.047 12.8 0.0 1.0 1 0 0 1 1 1 0 Protein kinase domain UQ_con PF00179.21 ESA06359.1 - 6.5e-40 135.7 0.2 7.2e-40 135.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA06359.1 - 0.00062 19.6 0.1 0.00096 19.0 0.1 1.4 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 ESA06359.1 - 0.011 15.4 0.2 0.021 14.4 0.1 1.5 1 1 0 1 1 1 0 UEV domain Prok-E2_B PF14461.1 ESA06359.1 - 0.016 14.9 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B F-box-like PF12937.2 ESA06361.1 - 9.6e-06 25.2 0.0 2.9e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like Imm14 PF15428.1 ESA06362.1 - 0.004 17.5 2.2 0.22 11.9 0.1 2.1 1 1 1 2 2 2 2 Immunity protein 14 ATXN-1_C PF12547.3 ESA06362.1 - 3.5 7.6 11.8 2.9 7.9 0.2 3.2 2 1 1 3 3 3 0 Capicua transcriptional repressor modulator Pkinase PF00069.20 ESA06364.1 - 1.7e-25 89.6 0.1 1.8e-25 89.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06364.1 - 1.8e-24 86.2 0.0 2e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA06364.1 - 0.034 13.8 0.1 0.044 13.5 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA06364.1 - 0.11 11.4 0.1 0.13 11.3 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF434 PF04256.7 ESA06365.1 - 0.0096 15.2 0.0 0.011 15.1 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF434) GCN5L1 PF06320.8 ESA06366.1 - 0.089 12.6 0.2 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Sel1 PF08238.7 ESA06367.1 - 3.1e-06 27.6 0.4 6.9e-06 26.5 0.3 1.6 1 1 0 1 1 1 1 Sel1 repeat DUF2209 PF09974.4 ESA06367.1 - 0.032 14.3 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Phage_Nu1 PF07471.7 ESA06367.1 - 0.13 11.7 0.0 0.14 11.5 0.0 1.0 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 F-box-like PF12937.2 ESA06368.1 - 0.003 17.2 0.4 0.0084 15.8 0.3 1.7 1 0 0 1 1 1 1 F-box-like Herpes_U15 PF05613.6 ESA06368.1 - 0.028 14.7 0.5 0.028 14.7 0.3 2.4 3 1 0 3 3 3 0 Human herpesvirus U15 protein DUF87 PF01935.12 ESA06369.1 - 0.015 15.1 0.3 0.016 15.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 AKAP_110 PF05716.8 ESA06369.1 - 0.039 11.9 0.4 0.089 10.7 0.2 1.4 1 1 1 2 2 2 0 A-kinase anchor protein 110 kDa (AKAP 110) EST1_DNA_bind PF10373.4 ESA06369.1 - 0.17 11.0 1.0 1.4 8.0 0.5 1.9 1 1 1 2 2 2 0 Est1 DNA/RNA binding domain PigN PF04987.9 ESA06370.1 - 7.4e-112 374.2 33.9 7.4e-112 374.2 23.5 1.4 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) YbhQ PF11076.3 ESA06370.1 - 3 7.4 11.3 1.2 8.7 1.4 2.7 3 0 0 3 3 3 0 Putative inner membrane protein YbhQ PalH PF08733.5 ESA06371.1 - 0.25 10.1 2.8 0.3 9.8 2.0 1.0 1 0 0 1 1 1 0 PalH/RIM21 Peptidase_S32 PF05579.8 ESA06372.1 - 0.044 12.7 0.1 4.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 PD40 PF07676.7 ESA06372.1 - 0.07 12.8 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Gal_mutarotas_2 PF13802.1 ESA06373.1 - 0.073 12.9 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 Galactose mutarotase-like Smr PF01713.16 ESA06374.1 - 3.3e-08 33.5 0.0 3.7e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Smr domain CytochromB561_N PF09786.4 ESA06375.1 - 4.2 5.7 7.2 5 5.4 5.0 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal NDT80_PhoG PF05224.7 ESA06379.1 - 5.6e-39 134.0 0.5 1e-38 133.2 0.0 1.7 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family TLD PF07534.11 ESA06380.1 - 8e-12 45.3 1.8 2.3e-11 43.8 1.2 1.7 1 1 0 1 1 1 1 TLD Myb_DNA-binding PF00249.26 ESA06381.1 - 0.0049 16.8 0.0 0.0082 16.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Mis14 PF08641.7 ESA06381.1 - 0.045 13.8 0.0 0.067 13.2 0.0 1.4 1 1 0 1 1 1 0 Kinetochore protein Mis14 like Myb_DNA-bind_6 PF13921.1 ESA06381.1 - 0.14 12.2 0.8 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain TLD PF07534.11 ESA06383.1 - 5.4e-18 65.3 1.4 5.4e-18 65.3 1.0 1.5 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA06384.1 - 2.5e-07 30.6 0.0 2.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA06385.1 - 1.6e-10 41.0 0.2 2.3e-10 40.5 0.2 1.2 1 0 0 1 1 1 1 TLD cNMP_binding PF00027.24 ESA06388.1 - 1.1e-45 153.3 0.0 1.4e-22 79.2 0.0 2.1 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Integrase_1 PF12835.2 ESA06389.1 - 0.028 14.1 1.5 2.2 8.0 0.0 2.2 1 1 1 2 2 2 0 Integrase Sigma_1_2 PF03084.9 ESA06389.1 - 0.38 9.3 1.9 2.9 6.4 0.2 2.0 1 1 1 2 2 2 0 Reoviral Sigma1/Sigma2 family bZIP_1 PF00170.16 ESA06391.1 - 9.9e-10 38.2 10.2 9.9e-10 38.2 7.1 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 ESA06391.1 - 1.6e-09 37.4 14.1 1.6e-09 37.4 9.7 1.7 1 1 1 2 2 2 1 Basic region leucine zipper WD40_alt PF14077.1 ESA06391.1 - 0.014 15.0 0.3 0.029 14.0 0.2 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF1192 PF06698.6 ESA06391.1 - 0.049 13.4 0.6 0.049 13.4 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) SAGA-Tad1 PF12767.2 ESA06391.1 - 0.098 12.3 2.9 0.12 11.9 2.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit ApoO PF09769.4 ESA06391.1 - 0.13 11.9 1.5 0.19 11.4 1.0 1.3 1 0 0 1 1 1 0 Apolipoprotein O Macoilin PF09726.4 ESA06391.1 - 0.18 10.0 2.7 0.2 9.8 1.9 1.0 1 0 0 1 1 1 0 Transmembrane protein CDC45 PF02724.9 ESA06391.1 - 0.26 9.2 5.4 0.32 8.9 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein bZIP_Maf PF03131.12 ESA06391.1 - 0.99 9.7 13.0 1.5 9.1 8.9 1.4 1 1 0 1 1 1 0 bZIP Maf transcription factor ABC_membrane PF00664.18 ESA06392.1 - 3.6e-32 111.8 11.4 4.9e-32 111.4 7.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Lebercilin PF15619.1 ESA06393.1 - 0.00077 18.9 7.4 0.00091 18.6 5.1 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease LAP2alpha PF11560.3 ESA06393.1 - 0.11 11.6 0.7 0.17 11.0 0.4 1.3 1 1 0 1 1 1 0 Lamina-associated polypeptide 2 alpha DHquinase_II PF01220.14 ESA06393.1 - 0.55 9.5 3.2 0.39 10.0 1.0 1.5 1 1 0 1 1 1 0 Dehydroquinase class II DUF2616 PF11077.3 ESA06396.1 - 0.00052 19.5 0.3 0.00052 19.5 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2616) DUF4339 PF14237.1 ESA06396.1 - 0.099 12.2 0.0 46 3.7 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4339) STAG PF08514.6 ESA06396.1 - 0.74 9.5 4.6 4.4 7.0 0.2 2.7 2 0 0 2 2 2 0 STAG domain DUF2616 PF11077.3 ESA06397.1 - 0.0042 16.5 2.7 0.0048 16.3 0.2 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF2616) hGDE_N PF14699.1 ESA06397.1 - 0.46 10.3 3.5 3.6 7.5 0.1 2.5 2 0 0 2 2 2 0 N-terminal domain from the human glycogen debranching enzyme Carbpep_Y_N PF05388.6 ESA06398.1 - 0.054 13.6 0.2 0.071 13.2 0.2 1.1 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide Ecl1 PF12855.2 ESA06399.1 - 0.0079 15.4 0.7 0.015 14.5 0.5 1.4 1 0 0 1 1 1 1 Life-span regulatory factor F-box-like PF12937.2 ESA06401.1 - 0.00021 20.9 2.8 0.00058 19.5 1.9 1.7 1 0 0 1 1 1 1 F-box-like BTD PF09270.5 ESA06403.1 - 6.4e-24 84.4 0.0 4.2e-22 78.5 0.0 3.0 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.6 ESA06403.1 - 3.9e-20 72.7 0.0 6.8e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 LAG1, DNA binding PRP1_N PF06424.7 ESA06404.1 - 0.041 14.1 0.8 0.11 12.7 0.5 1.7 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal HisKA_2 PF07568.7 ESA06404.1 - 0.11 12.3 0.2 0.34 10.7 0.0 1.9 2 1 0 2 2 2 0 Histidine kinase Sel1 PF08238.7 ESA06408.1 - 1.5e-18 66.7 2.7 1.7e-13 50.7 0.1 2.3 3 0 0 3 3 3 2 Sel1 repeat MIT PF04212.13 ESA06408.1 - 0.12 12.3 2.4 4.8 7.1 1.4 2.5 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain AD PF09793.4 ESA06409.1 - 0.013 15.3 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Anticodon-binding domain CCDC92 PF14916.1 ESA06410.1 - 0.018 14.6 0.9 0.018 14.6 0.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain of unknown function DUF3656 PF12392.3 ESA06410.1 - 0.084 12.9 1.1 0.16 12.0 0.1 1.8 1 1 1 2 2 2 0 Collagenase FtsJ PF01728.14 ESA06411.1 - 2.4e-31 109.1 0.0 3.7e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3412 PF11892.3 ESA06411.1 - 0.012 15.4 0.4 2.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3412) UPF0228 PF05727.6 ESA06411.1 - 0.06 13.0 3.3 0.07 12.8 1.1 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0228) AflR PF08493.5 ESA06412.1 - 4.6 6.1 10.8 8.2 5.3 7.5 1.4 1 0 0 1 1 1 0 Aflatoxin regulatory protein DUF2207 PF09972.4 ESA06413.1 - 0.008 14.8 0.7 0.016 13.8 0.2 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) ASC PF00858.19 ESA06413.1 - 0.37 9.3 3.5 16 3.9 0.0 3.1 2 1 2 4 4 4 0 Amiloride-sensitive sodium channel DUSP PF06337.7 ESA06414.1 - 0.083 13.2 1.9 0.14 12.5 1.2 1.5 1 1 0 1 1 1 0 DUSP domain TFIID_90kDa PF04494.10 ESA06414.1 - 0.53 10.3 3.1 9.3 6.2 0.0 2.5 3 0 0 3 3 3 0 WD40 associated region in TFIID subunit UQ_con PF00179.21 ESA06415.1 - 5.9e-09 35.4 0.1 6.5e-09 35.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box-like PF12937.2 ESA06416.1 - 0.045 13.4 1.3 0.21 11.3 0.9 2.2 1 0 0 1 1 1 0 F-box-like Toxin_22 PF08092.6 ESA06417.1 - 0.0037 17.0 0.0 4.6 7.1 0.0 2.5 2 0 0 2 2 2 2 Magi peptide toxin family Ribosomal_L16 PF00252.13 ESA06417.1 - 0.13 12.0 0.3 10 5.9 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L16p/L10e DAP_epimerase PF01678.14 ESA06418.1 - 5.7e-09 35.9 0.0 0.0043 16.9 0.0 2.3 2 0 0 2 2 2 2 Diaminopimelate epimerase VPS9 PF02204.13 ESA06419.1 - 2.9e-32 110.7 0.0 5e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF848 PF05852.6 ESA06420.1 - 0.28 11.0 7.9 0.34 10.7 5.5 1.1 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Frataxin_Cyay PF01491.11 ESA06421.1 - 5.9e-34 116.1 0.0 7.7e-34 115.7 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain Exo_endo_phos PF03372.18 ESA06423.1 - 5.8e-05 23.1 0.2 6.9e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Myb_DNA-bind_6 PF13921.1 ESA06424.1 - 2.2e-38 130.1 4.7 1.5e-14 53.8 0.0 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA06424.1 - 2.1e-37 126.9 6.8 1.4e-12 47.4 0.1 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 ESA06424.1 - 3.6e-05 23.8 8.0 0.42 10.7 0.1 3.9 3 1 0 3 3 3 3 Myb/SANT-like DNA-binding domain Rap1_C PF11626.3 ESA06424.1 - 0.00028 20.7 2.2 1.4 8.8 0.0 3.3 1 1 2 3 3 3 3 TRF2-interacting telomeric protein/Rap1 - C terminal domain Sel1 PF08238.7 ESA06425.1 - 3.2e-18 65.7 12.6 1.2e-09 38.5 0.8 3.0 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ESA06425.1 - 0.057 13.8 1.1 1.3 9.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA06425.1 - 4.7 7.3 6.3 9.7 6.3 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Dimer_Tnp_hAT PF05699.9 ESA06426.1 - 2.2e-17 62.4 1.0 1e-16 60.3 0.1 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Folliculin PF11704.3 ESA06426.1 - 0.058 12.9 0.1 5.2 6.6 0.0 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Dimer_Tnp_hAT PF05699.9 ESA06427.1 - 3.7e-16 58.5 1.1 3.9e-16 58.4 0.1 1.5 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ESA06429.1 - 0.076 12.0 0.0 0.098 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DcpS_C PF11969.3 ESA06430.1 - 8.7e-29 100.1 0.7 1.1e-28 99.8 0.5 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 ESA06430.1 - 9.4e-16 58.1 2.0 1.9e-15 57.1 1.4 1.4 1 1 0 1 1 1 1 HIT domain CwfJ_C_1 PF04677.10 ESA06430.1 - 0.14 11.8 1.7 0.44 10.2 1.2 1.9 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 SRP9-21 PF05486.7 ESA06431.1 - 2.4e-15 55.9 1.1 2.9e-15 55.7 0.8 1.1 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Mito_carr PF00153.22 ESA06432.1 - 5.6e-30 102.8 6.8 1.9e-13 49.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Cauli_DNA-bind PF03310.8 ESA06433.1 - 0.22 11.3 2.1 0.45 10.3 1.5 1.5 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Glyoxal_oxid_N PF07250.6 ESA06434.1 - 2.4e-40 138.1 0.0 1.8e-39 135.2 0.0 2.1 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ESA06434.1 - 5.5e-15 55.2 0.0 1.6e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.1 ESA06434.1 - 1.2e-05 25.2 1.0 1.6 9.0 0.0 5.3 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.1 ESA06434.1 - 0.00034 20.2 3.7 0.21 11.3 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA06434.1 - 0.022 14.3 3.3 0.24 10.9 0.1 4.1 5 0 0 5 5 5 0 Kelch motif DEK_C PF08766.6 ESA06435.1 - 0.0059 16.3 0.4 7 6.5 0.0 3.8 3 1 0 3 3 3 1 DEK C terminal domain Myb_DNA-bind_3 PF12776.2 ESA06435.1 - 0.21 12.2 16.0 2.4 8.8 0.9 3.3 1 1 3 4 4 4 0 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA06435.1 - 0.22 11.6 2.3 19 5.3 0.1 3.0 3 0 0 3 3 3 0 Myb-like DNA-binding domain NAAA-beta PF15508.1 ESA06435.1 - 0.51 10.7 2.8 54 4.2 0.1 3.6 2 1 2 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Myb_DNA-bind_6 PF13921.1 ESA06435.1 - 2.8 8.0 8.3 0.9 9.6 0.7 3.2 2 2 1 3 3 3 0 Myb-like DNA-binding domain Ion_trans PF00520.26 ESA06436.1 - 0.00063 19.0 5.9 0.00092 18.5 4.1 1.2 1 0 0 1 1 1 1 Ion transport protein ubiquitin PF00240.18 ESA06437.1 - 5e-16 57.8 0.1 9.3e-16 56.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA06437.1 - 2.2e-09 36.8 0.1 4.3e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA06437.1 - 0.0011 19.1 0.5 0.0057 16.8 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain PARP PF00644.15 ESA06437.1 - 0.0036 16.7 0.0 0.0056 16.1 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ESA06437.1 - 0.012 15.0 0.1 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DUF2407 PF10302.4 ESA06437.1 - 0.024 14.8 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA06437.1 - 0.046 13.5 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4113 PF13438.1 ESA06437.1 - 0.13 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4113) UPF0257 PF06788.8 ESA06438.1 - 0.14 11.3 0.1 0.14 11.3 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) Toxin_9 PF02819.10 ESA06440.1 - 0.51 10.4 9.2 1.6 8.8 6.4 1.8 1 0 0 1 1 1 0 Spider toxin BTB PF00651.26 ESA06442.1 - 2.6e-13 49.9 0.1 5.1e-13 48.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA06442.1 - 0.0027 17.5 1.0 0.0093 15.7 0.3 2.2 1 1 0 1 1 1 1 BTB And C-terminal Kelch PAS_3 PF08447.6 ESA06444.1 - 3.6e-15 55.8 0.0 6.5e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 ESA06444.1 - 1.1e-11 44.5 0.0 8.2e-11 41.6 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.1 ESA06444.1 - 1.9e-11 44.2 0.0 5.3e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.1 ESA06444.1 - 1.3e-10 41.1 0.0 2.6e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 PAS domain GATA PF00320.22 ESA06444.1 - 6e-06 25.4 0.7 1.6e-05 24.1 0.5 1.7 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.5 ESA06444.1 - 7e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold TF_Zn_Ribbon PF08271.7 ESA06444.1 - 0.015 14.6 0.5 0.042 13.1 0.3 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding Cu-oxidase_3 PF07732.10 ESA06445.1 - 2.4e-34 117.6 1.4 2.7e-34 117.4 1.0 1.0 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA06445.1 - 0.022 14.2 0.2 0.025 14.0 0.2 1.3 1 1 0 1 1 1 0 Multicopper oxidase VHL PF01847.11 ESA06445.1 - 0.13 11.8 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 von Hippel-Lindau disease tumour suppressor protein DUF500 PF04366.7 ESA06446.1 - 2e-46 156.5 0.7 4.1e-46 155.5 0.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF500) SH3_1 PF00018.23 ESA06446.1 - 1.2e-17 63.0 0.3 2.8e-17 61.8 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA06446.1 - 1e-14 53.8 0.1 1.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA06446.1 - 9.7e-10 37.7 0.0 1.8e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Chloroplast_duf PF14476.1 ESA06446.1 - 0.15 10.8 0.0 0.37 9.5 0.0 1.6 2 0 0 2 2 2 0 Petal formation-expressed GH97_C PF14509.1 ESA06446.1 - 0.22 11.6 1.0 1.7 8.7 0.0 2.7 3 0 0 3 3 3 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation PMSI1 PF15322.1 ESA06446.1 - 0.66 9.0 4.0 0.96 8.4 2.8 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative gerPA PF10676.4 ESA06446.1 - 0.85 9.5 5.5 0.12 12.2 0.7 2.0 2 0 0 2 2 2 0 Spore germination protein gerPA/gerPF TLD PF07534.11 ESA06447.1 - 1.4e-10 41.3 0.9 2.6e-10 40.4 0.6 1.5 1 1 0 1 1 1 1 TLD TNV_CP PF03898.8 ESA06447.1 - 0.041 12.9 0.0 0.057 12.4 0.0 1.1 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein F-box-like PF12937.2 ESA06449.1 - 0.023 14.4 2.3 0.059 13.1 0.4 2.5 2 1 0 2 2 2 0 F-box-like Peptidase_M10 PF00413.19 ESA06454.1 - 0.067 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Matrixin MRP-L46 PF11788.3 ESA06460.1 - 0.99 10.0 4.8 0.74 10.5 0.7 2.1 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 CMAS PF02353.15 ESA06461.1 - 0.085 11.9 0.1 0.092 11.8 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pkinase PF00069.20 ESA06462.1 - 0.0087 15.2 1.3 0.023 13.8 0.9 1.7 1 1 0 1 1 1 1 Protein kinase domain Cas_Cas4 PF01930.12 ESA06462.1 - 0.073 12.9 0.6 0.18 11.6 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF83 IF-2B PF01008.12 ESA06463.1 - 8.6e-29 100.4 14.0 1.4e-27 96.4 9.7 2.2 1 1 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.23 ESA06463.1 - 2.3e-11 43.4 0.0 4.1e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain XendoU PF09412.5 ESA06464.1 - 0.04 12.9 4.6 0.041 12.9 3.2 1.1 1 0 0 1 1 1 0 Endoribonuclease XendoU TEX12 PF15219.1 ESA06464.1 - 0.29 11.1 2.5 0.37 10.7 1.7 1.4 1 1 0 1 1 1 0 Testis-expressed 12 DUF948 PF06103.6 ESA06464.1 - 0.5 10.2 2.1 0.68 9.8 1.5 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PIN_2 PF10130.4 ESA06464.1 - 0.52 10.3 2.7 0.36 10.8 0.8 1.5 1 1 1 2 2 2 0 PIN domain DUF2570 PF10828.3 ESA06464.1 - 1 8.9 10.0 1.2 8.7 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) ATP11 PF06644.6 ESA06466.1 - 1.6e-25 90.1 8.1 2.1e-25 89.7 5.6 1.1 1 0 0 1 1 1 1 ATP11 protein Peptidase_M29 PF02073.10 ESA06466.1 - 0.07 11.8 2.4 0.083 11.6 1.6 1.2 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) PocR PF10114.4 ESA06466.1 - 0.29 10.2 1.7 0.51 9.4 1.2 1.4 1 0 0 1 1 1 0 Sensory domain found in PocR DUF1436 PF07262.6 ESA06467.1 - 0.00062 19.2 1.4 0.0015 18.0 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1436) Pox_VLTF3 PF04947.9 ESA06467.1 - 0.0095 15.4 0.7 0.0095 15.4 0.5 1.6 2 0 0 2 2 2 1 Poxvirus Late Transcription Factor VLTF3 like Kdo PF06293.9 ESA06468.1 - 6.4e-06 25.3 0.2 7.3e-05 21.9 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA06468.1 - 0.00018 20.7 0.1 0.00019 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA06468.1 - 0.048 13.3 0.5 0.057 13.1 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family APH_6_hur PF04655.9 ESA06468.1 - 0.083 12.0 0.5 0.094 11.8 0.3 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Pkinase PF00069.20 ESA06469.1 - 2e-48 164.8 0.0 4.1e-24 85.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06469.1 - 5e-45 153.6 0.0 3e-25 88.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Chaperone_III PF07824.7 ESA06471.1 - 0.014 15.2 0.0 0.014 15.2 0.0 1.0 1 0 0 1 1 1 0 Type III secretion chaperone domain zf-CCCH PF00642.19 ESA06472.1 - 5.1e-21 73.8 15.2 4.7e-11 42.0 2.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESA06472.1 - 0.52 10.3 15.7 0.39 10.8 1.1 2.7 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type zf-CCHH PF10283.4 ESA06472.1 - 4.1 7.3 8.9 8.3 6.3 0.9 2.6 2 0 0 2 2 2 0 Zinc-finger (CX5CX6HX5H) motif DivIC PF04977.10 ESA06473.1 - 0.0011 18.3 4.4 0.0016 17.8 2.9 1.4 1 1 0 1 1 1 1 Septum formation initiator DUF948 PF06103.6 ESA06473.1 - 0.0014 18.4 0.3 0.0018 18.1 0.2 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) TLE_N PF03920.10 ESA06473.1 - 0.007 16.1 1.3 0.0088 15.8 0.9 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain GAS PF13851.1 ESA06473.1 - 0.0096 15.1 7.8 0.013 14.7 5.4 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF2216 PF10226.4 ESA06473.1 - 0.01 15.3 1.6 0.012 15.1 1.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) Lge1 PF11488.3 ESA06473.1 - 0.012 15.7 1.2 0.019 15.1 0.8 1.4 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF972 PF06156.8 ESA06473.1 - 0.02 15.2 5.0 0.02 15.2 3.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 ESA06473.1 - 0.02 14.6 4.5 0.024 14.3 3.1 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Crust_neurohorm PF01147.12 ESA06473.1 - 0.03 13.6 0.9 0.058 12.7 0.2 1.9 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family DUF904 PF06005.7 ESA06473.1 - 0.034 14.4 3.4 0.057 13.7 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) TSC22 PF01166.13 ESA06473.1 - 0.044 13.7 3.9 0.083 12.8 2.1 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family TMF_TATA_bd PF12325.3 ESA06473.1 - 0.055 13.2 3.8 0.071 12.8 2.7 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESA06473.1 - 0.13 11.8 3.3 0.15 11.6 2.3 1.1 1 0 0 1 1 1 0 IncA protein FYDLN_acid PF09538.5 ESA06473.1 - 0.2 12.2 6.1 0.095 13.2 2.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Prefoldin_2 PF01920.15 ESA06473.1 - 0.29 10.9 6.4 0.3 10.8 2.8 2.0 1 1 1 2 2 2 0 Prefoldin subunit bZIP_1 PF00170.16 ESA06473.1 - 0.3 11.0 4.5 0.35 10.8 2.1 1.9 1 1 1 2 2 2 0 bZIP transcription factor APG6 PF04111.7 ESA06473.1 - 0.36 9.8 7.9 0.41 9.6 5.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Prefoldin PF02996.12 ESA06473.1 - 0.39 10.3 7.2 4.1 7.0 0.9 2.8 1 1 2 3 3 3 0 Prefoldin subunit V_ATPase_I PF01496.14 ESA06473.1 - 1.1 7.0 4.2 1.1 7.0 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HALZ PF02183.13 ESA06473.1 - 1.5 8.6 7.0 2 8.1 1.8 2.6 2 1 1 3 3 3 0 Homeobox associated leucine zipper HSP70 PF00012.15 ESA06474.1 - 0.0045 14.9 0.0 0.0053 14.7 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein RGS PF00615.14 ESA06475.1 - 1e-22 80.4 5.4 2.3e-22 79.3 3.8 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain s48_45 PF07422.8 ESA06478.1 - 0.011 15.7 0.0 0.016 15.3 0.0 1.3 1 1 0 1 1 1 0 Sexual stage antigen s48/45 domain DUF2076 PF09849.4 ESA06478.1 - 0.2 11.6 1.2 0.29 11.1 0.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Prok-RING_1 PF14446.1 ESA06478.1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_5 PF14634.1 ESA06478.1 - 0.48 10.2 11.5 0.97 9.2 6.4 2.5 2 1 0 2 2 2 0 zinc-RING finger domain DZR PF12773.2 ESA06478.1 - 2.1 8.2 6.7 1.4 8.8 1.6 2.5 1 1 1 2 2 2 0 Double zinc ribbon DUF4475 PF14753.1 ESA06478.1 - 2.9 7.3 9.9 6.6 6.1 3.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4475) Pkinase_Tyr PF07714.12 ESA06479.1 - 4.5e-40 137.3 0.0 6.5e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06479.1 - 9.1e-34 116.7 0.0 1.8e-33 115.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain stn_TNFRSF12A PF12191.3 ESA06479.1 - 0.28 11.2 1.0 0.52 10.3 0.7 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Nup188 PF10487.4 ESA06480.1 - 0.018 12.9 0.5 0.02 12.8 0.4 1.0 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 MRP-S26 PF14943.1 ESA06480.1 - 0.023 14.2 0.5 0.038 13.5 0.4 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Carbpep_Y_N PF05388.6 ESA06480.1 - 0.12 12.4 0.8 0.72 10.0 0.1 2.1 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide TPR_12 PF13424.1 ESA06480.1 - 0.13 12.2 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat IncA PF04156.9 ESA06480.1 - 0.18 11.3 4.9 11 5.5 3.4 2.1 1 1 0 1 1 1 0 IncA protein Mod_r PF07200.8 ESA06480.1 - 0.27 11.1 4.7 0.92 9.4 2.9 2.0 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF904 PF06005.7 ESA06480.1 - 5.2 7.4 8.6 5.5 7.3 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF904) Trs65 PF12735.2 ESA06482.1 - 2.9e-24 85.9 13.6 9.9e-24 84.1 9.4 1.7 1 1 0 1 1 1 1 TRAPP trafficking subunit Trs65 DUF555 PF04475.7 ESA06482.1 - 0.002 18.1 0.0 0.0052 16.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF555) LAT PF15234.1 ESA06482.1 - 1.3 8.4 5.3 0.27 10.6 0.4 2.0 2 0 0 2 2 2 0 Linker for activation of T-cells TPR_1 PF00515.23 ESA06484.1 - 7e-91 294.4 32.0 1.1e-07 31.0 0.0 16.4 17 0 0 17 17 16 15 Tetratricopeptide repeat TPR_11 PF13414.1 ESA06484.1 - 1.3e-90 296.9 45.1 3.6e-14 52.1 0.1 9.4 5 3 6 11 11 11 11 TPR repeat TPR_2 PF07719.12 ESA06484.1 - 1.1e-75 243.5 31.4 1.2e-05 24.8 0.3 16.2 15 1 1 16 16 16 16 Tetratricopeptide repeat TPR_9 PF13371.1 ESA06484.1 - 3.8e-49 164.4 22.3 8.1e-08 32.0 0.1 11.2 4 3 6 12 12 12 10 Tetratricopeptide repeat TPR_8 PF13181.1 ESA06484.1 - 2e-43 142.9 33.6 0.00072 19.1 0.0 15.4 15 1 1 16 16 16 8 Tetratricopeptide repeat TPR_17 PF13431.1 ESA06484.1 - 6.8e-38 125.7 36.5 0.00055 19.9 0.0 16.3 15 2 2 17 17 17 9 Tetratricopeptide repeat TPR_12 PF13424.1 ESA06484.1 - 2.4e-35 120.3 35.3 9.3e-07 28.6 0.3 10.8 1 1 10 12 12 12 12 Tetratricopeptide repeat TPR_16 PF13432.1 ESA06484.1 - 1.4e-29 102.0 24.5 1.4e-06 28.8 0.1 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESA06484.1 - 2.4e-21 74.2 26.7 0.025 15.1 0.0 13.5 3 2 12 15 15 15 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA06484.1 - 2.5e-21 75.7 19.1 0.00017 21.8 0.0 9.4 8 2 1 9 9 9 4 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA06484.1 - 7e-16 57.1 29.0 0.051 12.8 0.0 12.7 13 0 0 13 13 13 4 SHNi-TPR TPR_15 PF13429.1 ESA06484.1 - 2.1e-15 56.5 7.3 0.17 10.9 0.1 8.9 3 2 4 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.1 ESA06484.1 - 1.4e-09 37.8 10.6 8.8 7.0 0.0 10.4 12 0 0 12 12 10 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA06484.1 - 2e-09 37.1 21.4 0.1 12.4 0.0 10.6 10 1 1 11 11 11 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 ESA06484.1 - 1.1e-08 34.1 20.6 2.3 8.2 0.0 10.5 12 0 0 12 12 11 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA06484.1 - 3.3e-08 33.5 22.9 0.00047 20.2 0.4 6.8 3 3 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.9 ESA06484.1 - 1.9e-05 24.0 3.7 0.87 8.7 0.0 5.6 4 1 2 6 6 6 1 Coatomer epsilon subunit Syntaxin-6_N PF09177.6 ESA06484.1 - 4.5e-05 23.7 0.3 5.8 7.3 0.0 6.0 5 2 1 6 6 6 0 Syntaxin 6, N-terminal DUF327 PF03885.8 ESA06484.1 - 8.2e-05 22.4 0.0 12 5.7 0.0 5.3 4 2 2 6 6 6 0 Protein of unknown function (DUF327) NARP1 PF12569.3 ESA06484.1 - 9.2e-05 21.3 4.9 0.42 9.3 0.0 4.6 3 2 0 5 5 5 1 NMDA receptor-regulated protein 1 MIT PF04212.13 ESA06484.1 - 0.00035 20.3 10.4 7.8 6.4 0.0 7.0 6 2 2 8 8 8 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.4 ESA06484.1 - 0.0045 16.9 3.2 11 5.9 0.1 5.3 2 2 5 7 7 7 0 Tetratricopeptide repeat BTAD PF03704.12 ESA06484.1 - 0.027 14.7 5.9 9.6 6.4 0.4 4.5 4 1 0 4 4 4 0 Bacterial transcriptional activator domain Mga PF05043.8 ESA06484.1 - 0.083 13.1 0.8 12 6.2 0.0 4.6 5 2 1 6 6 5 0 Mga helix-turn-helix domain DUF3908 PF13048.1 ESA06484.1 - 0.15 12.0 3.6 0.52 10.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3908) TPR_10 PF13374.1 ESA06484.1 - 0.21 11.5 34.8 4.1 7.4 0.2 9.4 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA06484.1 - 0.31 11.2 8.1 17 5.6 0.0 5.4 4 2 0 5 5 5 0 Tetratricopeptide repeat DUF3856 PF12968.2 ESA06484.1 - 0.87 9.4 10.5 33 4.2 0.0 5.9 5 2 1 7 7 7 0 Domain of Unknown Function (DUF3856) PPTA PF01239.17 ESA06484.1 - 3.1 7.3 0.0 3.1 7.3 0.0 4.4 5 0 0 5 5 5 0 Protein prenyltransferase alpha subunit repeat Helicase_Sgs1 PF11408.3 ESA06485.1 - 0.012 15.4 0.1 0.75 9.6 0.1 2.2 1 1 0 1 1 1 0 Sgs1 RecQ helicase DUF3905 PF13045.1 ESA06485.1 - 0.027 14.2 1.9 0.042 13.6 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3905) zf-C2H2 PF00096.21 ESA06486.1 - 3.5e-12 45.8 11.8 5.4e-06 26.4 2.7 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA06486.1 - 1.6e-10 40.5 10.0 2e-05 24.6 0.7 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA06486.1 - 1.7e-09 37.4 12.3 1.6e-07 31.2 1.0 2.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESA06486.1 - 1.4e-05 25.0 4.9 0.0019 18.2 0.2 2.1 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 ESA06486.1 - 3.8e-05 23.6 10.0 0.00062 19.8 1.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-BED PF02892.10 ESA06486.1 - 0.0033 17.1 3.3 0.034 13.8 0.1 2.2 2 0 0 2 2 2 1 BED zinc finger PyrI_C PF02748.10 ESA06486.1 - 0.0053 16.1 2.7 0.0078 15.6 0.3 2.0 1 1 1 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Prok-RING_1 PF14446.1 ESA06486.1 - 0.019 14.6 1.3 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-CHY PF05495.7 ESA06486.1 - 0.031 14.4 2.7 0.041 14.0 1.9 1.3 1 0 0 1 1 1 0 CHY zinc finger zf-C2H2_6 PF13912.1 ESA06486.1 - 0.032 14.1 9.0 0.57 10.1 0.1 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger Hepcidin PF06446.7 ESA06486.1 - 0.054 13.9 2.3 0.077 13.4 1.6 1.4 1 1 0 1 1 1 0 Hepcidin Zn-ribbon_8 PF09723.5 ESA06486.1 - 0.058 13.3 2.8 3.8 7.5 0.2 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zf-met PF12874.2 ESA06486.1 - 0.08 13.1 3.9 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type C1_1 PF00130.17 ESA06486.1 - 0.11 12.2 3.0 1.2 8.8 2.3 2.0 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CotJA PF11007.3 ESA06486.1 - 0.11 12.1 0.2 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Spore coat associated protein JA (CotJA) SprT-like PF10263.4 ESA06486.1 - 0.11 12.0 1.2 0.12 11.9 0.9 1.1 1 0 0 1 1 1 0 SprT-like family zf-C2H2_2 PF12756.2 ESA06486.1 - 0.16 12.0 4.7 0.42 10.7 0.2 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.1 ESA06486.1 - 0.22 11.2 0.4 0.22 11.2 0.3 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Laminin_EGF PF00053.19 ESA06486.1 - 0.26 11.2 2.8 1.7 8.6 0.3 2.0 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) zf-AN1 PF01428.11 ESA06486.1 - 0.28 11.0 8.3 2.1 8.2 1.5 2.1 1 1 1 2 2 2 0 AN1-like Zinc finger LIM PF00412.17 ESA06486.1 - 0.58 10.2 4.2 12 6.0 3.1 2.0 1 1 0 1 1 1 0 LIM domain Evr1_Alr PF04777.8 ESA06486.1 - 0.97 9.3 4.8 1.6 8.6 0.4 2.0 1 1 1 2 2 2 0 Erv1 / Alr family C1_4 PF07975.7 ESA06486.1 - 1.5 8.8 5.5 4.6 7.3 3.8 1.7 1 1 0 1 1 1 0 TFIIH C1-like domain TAFII55_N PF04658.8 ESA06489.1 - 0.0071 15.8 1.0 0.009 15.5 0.7 1.2 1 0 0 1 1 1 1 TAFII55 protein conserved region DUF2408 PF10303.4 ESA06489.1 - 0.032 14.3 3.7 0.044 13.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF999 PF06198.6 ESA06489.1 - 0.033 13.9 2.2 0.042 13.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF999) AAA_33 PF13671.1 ESA06489.1 - 0.083 12.7 0.3 0.1 12.4 0.2 1.1 1 0 0 1 1 1 0 AAA domain HpaB PF03241.8 ESA06490.1 - 0.14 10.9 0.0 0.15 10.8 0.0 1.0 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal VLPT PF07122.6 ESA06490.1 - 4.7 6.9 9.4 4.3 7.0 1.3 2.6 3 0 0 3 3 3 0 Variable length PCR target protein (VLPT) HEAT PF02985.17 ESA06492.1 - 0.0046 16.9 0.4 0.059 13.4 0.0 2.8 2 0 0 2 2 2 1 HEAT repeat Pkinase PF00069.20 ESA06493.1 - 2.9e-11 43.0 0.0 3.6e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06493.1 - 2.1e-09 36.8 0.0 2.5e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA06494.1 - 2.2e-24 85.3 6.8 7.7e-09 35.9 0.5 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_17 PF13431.1 ESA06494.1 - 0.045 13.9 1.2 3.6 8.0 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Trefoil PF00088.13 ESA06494.1 - 0.094 12.3 1.5 0.33 10.6 0.5 2.2 2 1 0 2 2 2 0 Trefoil (P-type) domain TPR_11 PF13414.1 ESA06494.1 - 0.73 9.5 4.0 19 5.0 2.7 2.7 1 1 0 1 1 1 0 TPR repeat Ribonuclease_T2 PF00445.13 ESA06497.1 - 0.031 13.8 0.1 0.031 13.8 0.0 1.0 1 0 0 1 1 1 0 Ribonuclease T2 family Sel1 PF08238.7 ESA06498.1 - 7.9e-87 283.8 29.6 1.5e-11 44.5 0.0 10.0 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA06498.1 - 3.1e-06 27.2 8.2 7 7.3 0.0 6.9 8 0 0 8 8 8 3 Tetratricopeptide repeat DUF512 PF04459.7 ESA06498.1 - 0.00026 20.1 0.3 0.73 8.8 0.0 3.1 3 1 1 4 4 4 2 Protein of unknown function (DUF512) DUF1508 PF07411.7 ESA06498.1 - 9.1 5.8 8.3 48 3.4 0.3 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF1508) Mid2 PF04478.7 ESA06499.1 - 0.082 12.3 0.5 0.14 11.5 0.3 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Sel1 PF08238.7 ESA06500.1 - 5.9e-13 48.9 10.4 2.2e-05 24.9 0.0 4.7 5 0 0 5 5 5 3 Sel1 repeat TPR_11 PF13414.1 ESA06500.1 - 0.29 10.8 7.7 6 6.5 0.6 3.4 2 1 1 3 3 3 0 TPR repeat TPR_8 PF13181.1 ESA06500.1 - 1.3 8.9 8.2 4.9 7.1 2.2 4.0 2 1 0 2 2 2 0 Tetratricopeptide repeat BPL_LplA_LipB PF03099.14 ESA06501.1 - 3.1e-15 56.2 0.1 6.2e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Eaf7 PF07904.8 ESA06501.1 - 0.062 13.2 0.1 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 TPP1 PF10341.4 ESA06502.1 - 0.024 14.6 1.3 0.03 14.3 0.6 1.4 1 1 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD DUF1910 PF08928.5 ESA06502.1 - 1.2 9.1 7.8 1.4 8.9 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) DUF1635 PF07795.6 ESA06502.1 - 1.9 7.8 6.6 1.9 7.7 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Kelch_5 PF13854.1 ESA06503.1 - 9.2e-06 25.4 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.1 ESA06503.1 - 0.0035 17.0 0.0 0.0083 15.8 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA06503.1 - 0.0078 15.9 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.20 ESA06503.1 - 0.01 15.3 0.3 0.024 14.1 0.0 1.8 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.1 ESA06503.1 - 0.016 15.3 0.0 0.04 14.1 0.0 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.1 ESA06504.1 - 1.4e-06 28.0 0.6 0.26 11.2 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESA06504.1 - 2.7e-06 26.8 9.3 0.06 12.8 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.1 ESA06504.1 - 1.2e-05 24.9 12.2 0.1 12.4 0.0 5.7 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA06504.1 - 1.2e-05 25.2 9.9 0.23 11.6 0.1 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA06504.1 - 4.1e-05 23.5 10.4 0.035 14.2 0.0 5.1 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.10 ESA06504.1 - 5.7e-05 22.7 5.8 0.026 14.2 0.0 4.6 5 1 0 5 5 5 2 Kelch motif Exo_endo_phos_2 PF14529.1 ESA06506.1 - 0.1 12.2 0.1 0.1 12.2 0.1 2.3 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Rad50_zn_hook PF04423.9 ESA06506.1 - 0.69 9.4 0.0 0.69 9.4 0.0 4.2 4 1 1 5 5 5 0 Rad50 zinc hook motif DUF413 PF04219.7 ESA06506.1 - 7.6 6.3 13.0 6.4 6.5 1.3 3.5 2 1 1 3 3 3 0 Protein of unknown function, DUF RNase_H PF00075.19 ESA06507.1 - 0.095 13.0 0.0 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 RNase H DPPIV_N PF00930.16 ESA06508.1 - 8.2e-101 337.1 4.6 1e-100 336.8 3.2 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF3543 PF12063.3 ESA06509.1 - 0.014 14.5 0.1 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) Wx5_PLAF3D7 PF09688.5 ESA06509.1 - 0.021 14.7 1.1 0.024 14.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) AlaDh_PNT_C PF01262.16 ESA06509.1 - 0.11 12.1 0.1 0.12 11.9 0.1 1.0 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thioredoxin_8 PF13905.1 ESA06510.1 - 0.053 13.6 0.3 3.2 7.9 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like Dimer_Tnp_hAT PF05699.9 ESA06511.1 - 5.1e-17 61.2 0.4 1.3e-16 59.9 0.1 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region 5_3_exonuc_N PF02739.11 ESA06511.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF4413 PF14372.1 ESA06511.1 - 0.049 13.6 0.3 0.78 9.7 0.0 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4413) p450 PF00067.17 ESA06513.1 - 1.1e-23 83.4 0.4 2.1e-23 82.5 0.2 1.4 1 1 0 1 1 1 1 Cytochrome P450 Virul_Fac PF10139.4 ESA06513.1 - 0.012 13.6 0.0 0.018 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor DUF4653 PF15546.1 ESA06513.1 - 0.06 12.6 0.0 0.088 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) HMG_box PF00505.14 ESA06514.1 - 5e-05 23.4 0.1 8.1e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06514.1 - 0.017 15.4 0.1 0.03 14.6 0.1 1.4 1 0 0 1 1 1 0 HMG-box domain G-alpha PF00503.15 ESA06515.1 - 6.4e-118 393.8 0.5 7.9e-118 393.5 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 ESA06515.1 - 3e-13 49.3 2.2 1.7e-08 33.8 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA06515.1 - 0.0045 16.1 3.1 0.21 10.7 0.1 2.4 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA06515.1 - 0.014 15.8 0.2 3.3 8.2 0.1 2.7 2 1 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 ESA06515.1 - 0.038 13.5 0.1 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 ESA06515.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family YL1_C PF08265.6 ESA06519.1 - 1.2e-14 53.5 0.2 2.4e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain YL1 PF05764.8 ESA06519.1 - 2.3e-13 50.3 5.8 2.3e-13 50.3 4.0 2.0 2 1 0 2 2 2 1 YL1 nuclear protein zf-HIT PF04438.11 ESA06519.1 - 0.079 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 HIT zinc finger YL1 PF05764.8 ESA06520.1 - 1.7e-09 37.6 0.4 2e-09 37.4 0.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Phosphodiest PF01663.17 ESA06521.1 - 3.3e-12 46.4 0.3 3.3e-12 46.4 0.2 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 ESA06521.1 - 0.00011 21.5 0.1 0.011 14.9 0.0 2.3 1 1 0 2 2 2 2 Sulfatase Metalloenzyme PF01676.13 ESA06521.1 - 0.00028 20.3 0.1 0.00051 19.5 0.1 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily VitK2_biosynth PF02621.9 ESA06521.1 - 0.095 11.8 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Menaquinone biosynthesis Kelch_5 PF13854.1 ESA06522.1 - 7.2e-17 60.9 9.4 0.0052 16.7 0.0 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA06522.1 - 1.2e-16 60.1 14.8 0.00072 19.2 0.1 6.4 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA06522.1 - 1.2e-10 40.7 1.9 0.014 15.0 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 ESA06522.1 - 8.1e-10 38.4 18.6 0.0056 16.8 0.5 5.9 4 1 2 6 6 6 3 Kelch motif Kelch_3 PF13415.1 ESA06522.1 - 5.6e-08 32.7 11.6 0.027 14.6 0.1 6.8 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA06522.1 - 4.8e-07 29.2 18.2 0.095 12.2 0.6 5.0 5 0 0 5 5 5 4 Kelch motif Tup_N PF08581.5 ESA06524.1 - 0.00073 19.6 33.9 0.0039 17.3 11.2 4.3 1 1 2 3 3 3 1 Tup N-terminal DUF3584 PF12128.3 ESA06524.1 - 0.0014 16.1 23.1 0.0018 15.7 16.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Phage_GP20 PF06810.6 ESA06524.1 - 0.011 15.2 14.8 0.011 15.2 10.2 3.6 1 1 3 4 4 4 0 Phage minor structural protein GP20 HALZ PF02183.13 ESA06524.1 - 0.2 11.4 27.1 0.14 11.9 1.9 5.0 3 2 1 4 4 4 0 Homeobox associated leucine zipper Apolipoprotein PF01442.13 ESA06524.1 - 0.2 11.1 25.5 0.48 9.8 15.6 2.5 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain YlqD PF11068.3 ESA06524.1 - 0.29 11.1 31.3 4.3 7.3 8.0 3.1 1 1 3 4 4 4 0 YlqD protein GA PF01468.12 ESA06524.1 - 0.34 11.1 8.6 3.8 7.7 0.6 3.9 2 1 0 3 3 3 0 GA module TPR_MLP1_2 PF07926.7 ESA06524.1 - 0.37 10.5 38.3 0.16 11.7 13.1 3.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein COG5 PF10392.4 ESA06524.1 - 0.42 10.5 21.3 0.6 10.0 6.6 2.5 1 1 1 2 2 2 0 Golgi transport complex subunit 5 ACCA PF03255.9 ESA06524.1 - 0.46 10.0 23.7 0.2 11.1 4.4 3.4 3 1 1 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Atg14 PF10186.4 ESA06524.1 - 0.86 8.4 28.0 11 4.7 19.3 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.4 ESA06524.1 - 0.95 9.4 35.6 20 5.1 7.4 3.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.1 ESA06524.1 - 1.8 7.4 23.2 0.72 8.7 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) AHS1 PF02682.11 ESA06524.1 - 2.6 7.4 4.6 2.4 7.5 2.0 1.7 1 1 0 1 1 1 0 Allophanate hydrolase subunit 1 NYD-SP28_assoc PF14775.1 ESA06524.1 - 7.2 6.3 22.5 0.08 12.6 1.0 4.7 3 2 2 5 5 5 0 Sperm tail C-terminal domain Cep57_CLD_2 PF14197.1 ESA06524.1 - 7.6 6.5 27.5 4.3 7.3 0.3 4.9 2 1 2 4 4 3 0 Centrosome localisation domain of PPC89 VPS11_C PF12451.3 ESA06524.1 - 8.5 6.3 7.1 1.9 8.4 0.8 3.0 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal bZIP_1 PF00170.16 ESA06524.1 - 9.2 6.3 31.2 3.8 7.5 3.5 5.0 2 1 3 5 5 5 0 bZIP transcription factor GvpL_GvpF PF06386.6 ESA06524.1 - 9.4 5.7 15.6 24 4.3 9.8 2.2 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF4515 PF14988.1 ESA06524.1 - 10 5.7 37.2 47 3.5 19.0 4.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) Pkinase PF00069.20 ESA06525.1 - 3.6e-18 65.6 0.0 4.6e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06525.1 - 2.7e-15 56.1 0.0 3.4e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1100 PF06500.6 ESA06525.1 - 0.12 10.8 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) ATP-cone PF03477.11 ESA06526.1 - 0.07 13.5 0.1 0.23 11.9 0.0 1.8 2 0 0 2 2 2 0 ATP cone domain DUF3371 PF11851.3 ESA06527.1 - 0.047 14.3 0.5 0.058 14.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Opi1 PF08618.5 ESA06528.1 - 9.2e-47 159.9 32.8 3.4e-46 158.0 8.3 4.2 2 2 1 3 3 3 2 Transcription factor Opi1 DUF3068 PF11271.3 ESA06529.1 - 0.11 11.5 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3068) GshA PF08886.6 ESA06530.1 - 0.029 12.7 1.7 0.033 12.5 1.2 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase BAF1_ABF1 PF04684.8 ESA06530.1 - 1 8.1 8.4 1.2 7.9 5.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor OMPdecase PF00215.19 ESA06534.1 - 9e-09 35.0 0.1 1.2e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MRP_L53 PF10780.4 ESA06534.1 - 0.087 12.8 0.2 0.61 10.1 0.1 2.0 1 1 1 2 2 2 0 39S ribosomal protein L53/MRP-L53 GreA_GreB_N PF03449.10 ESA06534.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal AMP-binding PF00501.23 ESA06535.1 - 1.5e-71 241.0 0.0 2.4e-71 240.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.7 ESA06535.1 - 2.8e-70 236.0 0.0 5.8e-70 235.0 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.20 ESA06535.1 - 8.2e-13 48.4 0.0 2.6e-12 46.8 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 ESA06535.1 - 3.2e-10 39.8 0.0 6.9e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 ESA06535.1 - 1.3e-09 38.8 0.0 3.9e-09 37.3 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 ESA06535.1 - 1.4e-07 30.5 0.0 5.2e-07 28.6 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Condensation PF00668.15 ESA06535.1 - 1.4e-05 24.1 0.0 4.4e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Condensation domain AF-4 PF05110.8 ESA06535.1 - 0.47 8.2 0.1 0.68 7.7 0.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein HMG_box PF00505.14 ESA06536.1 - 6.8e-05 23.0 0.9 0.00016 21.8 0.6 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06536.1 - 0.057 13.7 0.8 0.057 13.7 0.6 2.7 3 0 0 3 3 3 0 HMG-box domain Bacillus_PapR PF05968.6 ESA06536.1 - 0.95 9.5 5.3 4.6 7.3 0.3 2.8 2 0 0 2 2 2 0 Bacillus PapR protein Acetate_kinase PF00871.12 ESA06537.1 - 7.6e-94 314.4 4.2 1.6e-93 313.3 2.9 1.5 1 1 0 1 1 1 1 Acetokinase family TLD PF07534.11 ESA06538.1 - 4.2e-10 39.7 0.8 6.1e-10 39.2 0.6 1.2 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA06538.1 - 0.046 13.5 0.7 0.97 9.3 0.1 2.7 2 1 1 3 3 3 0 BTB And C-terminal Kelch Arginosuc_synth PF00764.14 ESA06539.1 - 1.9e-155 517.7 0.0 2.2e-155 517.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.8 ESA06539.1 - 0.00039 19.7 0.0 0.00059 19.1 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 ESA06539.1 - 0.0066 15.0 0.0 0.0097 14.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 ESA06539.1 - 0.019 14.4 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase DUF4602 PF15375.1 ESA06540.1 - 7.1e-16 58.4 13.0 7.1e-16 58.4 9.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4602) CPSase_L_D3 PF02787.14 ESA06540.1 - 0.48 10.2 2.8 2.3 8.0 0.1 2.4 2 1 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain BHD_2 PF10404.4 ESA06540.1 - 0.56 10.5 5.2 0.29 11.4 0.8 2.3 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 2 FimP PF09766.4 ESA06541.1 - 4.1e-22 78.7 21.0 5.7e-22 78.2 14.6 1.2 1 0 0 1 1 1 1 Fms-interacting protein Arch_ATPase PF01637.13 ESA06543.1 - 0.0015 18.2 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase OstA_2 PF13100.1 ESA06543.1 - 0.09 12.0 0.1 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 OstA-like protein F-box-like PF12937.2 ESA06544.1 - 2.2e-06 27.2 0.2 6.1e-06 25.8 0.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA06544.1 - 0.0044 16.6 10.3 0.24 11.0 0.4 5.8 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) FlgN PF05130.7 ESA06545.1 - 0.067 13.4 0.2 0.095 12.9 0.1 1.3 1 0 0 1 1 1 0 FlgN protein DUF2543 PF10820.3 ESA06546.1 - 0.031 14.2 0.2 0.046 13.7 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2543) Pneumo_att_G PF05539.6 ESA06547.1 - 0.023 14.0 1.4 0.03 13.7 1.0 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G CKAP2_C PF15297.1 ESA06547.1 - 0.32 9.7 5.9 0.42 9.3 4.1 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus FRG2 PF15315.1 ESA06547.1 - 0.53 10.2 6.6 0.73 9.7 4.6 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 TFIIF_alpha PF05793.7 ESA06547.1 - 4.4 5.5 19.5 5.4 5.2 13.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SseC PF04888.7 ESA06549.1 - 0.023 14.0 0.3 0.023 14.0 0.2 1.8 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF2252 PF10009.4 ESA06549.1 - 2.6 6.8 20.0 0.049 12.5 5.4 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2252) RsbU_N PF08673.5 ESA06549.1 - 3.1 7.8 7.3 1.7 8.7 0.3 3.0 2 1 1 3 3 3 0 Phosphoserine phosphatase RsbU, N-terminal domain DUF4407 PF14362.1 ESA06549.1 - 4.9 6.0 18.8 37 3.1 12.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prothymosin PF03247.9 ESA06549.1 - 7.3 6.7 38.6 1.2 9.3 11.8 3.0 3 0 0 3 3 3 0 Prothymosin/parathymosin family MCRS_N PF13325.1 ESA06550.1 - 0.12 11.9 0.1 0.25 10.8 0.0 1.5 1 1 0 1 1 1 0 N-terminal region of micro-spherule protein Aldedh PF00171.17 ESA06551.1 - 2.5e-145 484.3 0.1 2.8e-145 484.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESA06551.1 - 0.049 12.8 0.0 5.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Response_reg PF00072.19 ESA06552.1 - 1.5e-15 57.1 0.0 7.2e-14 51.7 0.0 2.7 1 1 0 1 1 1 1 Response regulator receiver domain KaiC PF06745.8 ESA06552.1 - 0.051 12.6 0.1 0.051 12.6 0.0 1.9 2 0 0 2 2 2 0 KaiC Anemone_cytotox PF06369.7 ESA06553.1 - 2.4e-25 88.9 0.4 2.9e-25 88.6 0.3 1.0 1 0 0 1 1 1 1 Sea anemone cytotoxic protein Dioxygenase_C PF00775.16 ESA06554.1 - 0.058 12.6 0.0 0.064 12.5 0.0 1.0 1 0 0 1 1 1 0 Dioxygenase Rep_fac-A_C PF08646.5 ESA06555.1 - 0.017 14.8 1.7 0.038 13.6 1.2 1.6 1 0 0 1 1 1 0 Replication factor-A C terminal domain Baculo_E66 PF04850.7 ESA06555.1 - 0.044 12.7 2.1 0.064 12.2 1.5 1.2 1 0 0 1 1 1 0 Baculovirus E66 occlusion-derived virus envelope protein rRNA_methylase PF06962.7 ESA06555.1 - 0.055 13.1 0.3 12 5.5 0.0 3.4 3 1 1 4 4 4 0 Putative rRNA methylase Thioredoxin_2 PF13098.1 ESA06555.1 - 3.4 7.9 5.0 83 3.4 2.0 2.8 2 1 0 2 2 2 0 Thioredoxin-like domain DUF1053 PF06327.9 ESA06556.1 - 0.059 13.7 0.2 0.091 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Phage_H_T_join PF05521.6 ESA06557.1 - 0.014 15.6 0.2 0.015 15.6 0.2 1.0 1 0 0 1 1 1 0 Phage head-tail joining protein Orthopox_B11R PF07033.6 ESA06557.1 - 0.03 13.8 0.8 0.032 13.6 0.6 1.1 1 0 0 1 1 1 0 Orthopoxvirus B11R protein DUF725 PF05267.7 ESA06558.1 - 0.02 14.8 0.1 0.02 14.8 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF725) Fer4_10 PF13237.1 ESA06559.1 - 0.069 12.9 0.2 0.081 12.7 0.1 1.2 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.2 ESA06559.1 - 0.23 12.0 2.4 0.33 11.6 1.6 1.2 1 0 0 1 1 1 0 4Fe-4S binding domain Flu_NS1 PF00600.14 ESA06560.1 - 0.11 11.6 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 Influenza non-structural protein (NS1) Aldo_ket_red PF00248.16 ESA06567.1 - 1.9e-31 108.9 0.0 2e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family THF_DHG_CYH PF00763.18 ESA06568.1 - 2.5e-19 69.4 0.0 4.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 ESA06568.1 - 1.6e-11 43.5 0.2 1.6e-09 37.0 0.1 2.9 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain UDPG_MGDP_dh_N PF03721.9 ESA06568.1 - 0.029 13.7 0.2 0.15 11.4 0.2 2.1 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ino80_Iec3 PF14612.1 ESA06570.1 - 0.02 14.9 0.2 0.025 14.6 0.1 1.2 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Spore_YhcN_YlaJ PF09580.5 ESA06570.1 - 0.051 13.6 0.1 0.076 13.1 0.1 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Pox_ATPase-GT PF10640.4 ESA06570.1 - 0.42 9.3 6.7 0.34 9.6 0.6 2.0 1 1 1 2 2 2 0 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase DUF659 PF04937.10 ESA06572.1 - 3.2e-09 36.4 0.0 5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) RE_SinI PF09570.5 ESA06572.1 - 0.00041 19.4 0.1 0.00073 18.5 0.0 1.4 1 0 0 1 1 1 1 SinI restriction endonuclease FAR1 PF03101.10 ESA06574.1 - 1.4e-07 31.9 5.7 1.8e-07 31.5 4.0 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA06574.1 - 0.0022 17.5 1.6 0.23 11.0 0.0 2.4 2 1 0 2 2 2 2 MuDR family transposase Pkinase_Tyr PF07714.12 ESA06578.1 - 0.07 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Peptidase_C97 PF05903.9 ESA06580.1 - 0.0076 16.0 0.1 0.0093 15.7 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF500 PF04366.7 ESA06582.1 - 5.5e-41 138.9 0.8 1.1e-40 137.9 0.4 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF500) MMR_HSR1 PF01926.18 ESA06583.1 - 1.3e-20 73.5 0.4 2.5e-20 72.5 0.1 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA06583.1 - 5.4e-08 32.2 0.1 1.1e-07 31.2 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESA06583.1 - 1.8e-07 31.1 0.1 0.0044 16.8 0.1 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 ESA06583.1 - 1.5e-06 27.8 0.7 0.0001 21.8 0.5 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESA06583.1 - 9.4e-06 24.9 0.0 0.00017 20.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Septin PF00735.13 ESA06583.1 - 0.00087 18.3 2.8 0.36 9.8 1.3 2.6 1 1 0 1 1 1 1 Septin Miro PF08477.8 ESA06583.1 - 0.0013 19.2 0.1 0.0033 17.9 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 ESA06583.1 - 0.0016 17.6 0.0 0.0016 17.6 0.0 2.1 3 1 0 3 3 3 1 Signal recognition particle receptor beta subunit AIG1 PF04548.11 ESA06583.1 - 0.0024 17.0 0.0 0.0045 16.1 0.0 1.6 1 1 0 1 1 1 1 AIG1 family AAA_21 PF13304.1 ESA06583.1 - 0.012 15.6 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 ESA06583.1 - 0.014 14.8 0.1 0.027 13.9 0.0 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 ESA06583.1 - 0.015 15.0 0.0 0.043 13.5 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 ESA06583.1 - 0.031 13.8 0.0 0.059 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 ESA06583.1 - 0.032 15.0 0.0 0.13 13.1 0.0 2.0 1 1 1 2 2 2 0 AAA domain Ras PF00071.17 ESA06583.1 - 0.043 13.1 0.2 3.1 7.1 0.0 2.2 2 0 0 2 2 2 0 Ras family MULE PF10551.4 ESA06583.1 - 0.053 13.6 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 MULE transposase domain ABC_tran PF00005.22 ESA06583.1 - 0.065 13.5 0.0 0.1 12.9 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 ESA06583.1 - 0.13 12.3 0.2 0.84 9.7 0.0 2.3 2 1 0 2 2 2 0 AAA domain 7tm_1 PF00001.16 ESA06584.1 - 0.00065 18.9 10.8 0.073 12.1 1.0 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) OPT PF03169.10 ESA06585.1 - 1.7e-63 215.0 14.8 1.9e-63 214.9 10.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein OPT PF03169.10 ESA06586.1 - 4.2e-73 246.8 21.5 7e-72 242.7 14.9 2.4 1 1 0 1 1 1 1 OPT oligopeptide transporter protein F-box-like PF12937.2 ESA06588.1 - 0.0094 15.6 0.1 0.031 14.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like KOW PF00467.24 ESA06589.1 - 1.5e-08 33.9 5.0 1.3 8.9 0.0 5.6 5 0 0 5 5 5 3 KOW motif CTD PF12815.2 ESA06589.1 - 2e-08 34.6 24.8 1e-07 32.4 15.1 2.9 1 1 1 2 2 2 2 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5-NGN PF03439.8 ESA06589.1 - 6.6e-05 22.5 0.1 0.00015 21.4 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section zinc-ribbons_6 PF07191.7 ESA06590.1 - 0.021 14.6 0.6 0.032 13.9 0.4 1.3 1 0 0 1 1 1 0 zinc-ribbons DDHD PF02862.12 ESA06591.1 - 0.015 15.1 4.2 0.028 14.2 2.9 1.4 1 0 0 1 1 1 0 DDHD domain RNA_polI_A34 PF08208.6 ESA06591.1 - 0.44 10.1 17.6 0.87 9.2 12.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Sec62 PF03839.11 ESA06591.1 - 1.8 7.9 8.7 3.3 7.0 6.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.17 ESA06591.1 - 2.9 6.8 4.4 3.2 6.6 3.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF968 PF06147.6 ESA06592.1 - 0.0057 16.5 1.2 0.0097 15.8 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF968) HNH PF01844.18 ESA06592.1 - 8.5 6.3 7.6 7.5 6.5 3.0 2.6 2 1 0 2 2 2 0 HNH endonuclease TMEM240 PF15207.1 ESA06594.1 - 0.064 12.8 0.3 0.066 12.7 0.2 1.0 1 0 0 1 1 1 0 TMEM240 family Granulin PF00396.13 ESA06596.1 - 0.00016 21.6 21.4 0.13 12.3 6.1 2.7 1 1 2 3 3 3 2 Granulin Kinesin PF00225.18 ESA06598.1 - 5.9e-35 120.5 0.0 6.3e-35 120.4 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Pkinase PF00069.20 ESA06599.1 - 2.1e-12 46.7 1.7 2.4e-10 40.0 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06599.1 - 4.9e-11 42.1 0.1 6.7e-09 35.2 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase SUR7 PF06687.7 ESA06600.1 - 1.7e-05 24.5 4.1 1.7e-05 24.5 2.9 2.0 1 1 1 2 2 2 1 SUR7/PalI family Claudin_2 PF13903.1 ESA06600.1 - 3.2e-05 23.6 0.1 4e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction AA_permease_2 PF13520.1 ESA06600.1 - 0.00082 18.0 2.3 0.00096 17.7 1.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF973 PF06157.6 ESA06600.1 - 0.004 16.1 2.7 0.0057 15.6 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF973) IncA PF04156.9 ESA06600.1 - 0.0071 15.9 0.3 0.0071 15.9 0.2 1.6 2 0 0 2 2 2 1 IncA protein Claudin_3 PF06653.6 ESA06600.1 - 0.01 15.5 1.0 0.014 15.1 0.7 1.2 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Amastin PF07344.6 ESA06600.1 - 0.014 14.9 0.9 0.032 13.8 0.6 1.7 1 1 0 1 1 1 0 Amastin surface glycoprotein AA_permease PF00324.16 ESA06600.1 - 0.019 13.3 1.7 0.022 13.1 1.2 1.1 1 0 0 1 1 1 0 Amino acid permease DUF4418 PF14387.1 ESA06600.1 - 0.023 14.4 0.5 0.023 14.4 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4418) MscS_TM PF12794.2 ESA06600.1 - 0.049 12.2 0.0 0.064 11.8 0.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4064 PF13273.1 ESA06600.1 - 0.4 10.8 9.0 1.9 8.6 2.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) EphA2_TM PF14575.1 ESA06600.1 - 0.87 10.0 2.6 6.2 7.2 0.0 2.5 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Phage_holin_1 PF04531.8 ESA06600.1 - 7.4 6.7 8.5 65 3.6 0.3 2.9 2 1 1 3 3 3 0 Bacteriophage holin Tetraspannin PF00335.15 ESA06600.1 - 9.2 5.4 12.4 0.95 8.6 4.6 1.9 1 1 1 2 2 2 0 Tetraspanin family DDE_3 PF13358.1 ESA06602.1 - 5.1e-09 36.0 0.3 5.1e-09 36.0 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Uteroglobin PF01099.12 ESA06603.1 - 0.013 15.3 0.0 0.048 13.4 0.0 2.0 1 0 0 1 1 1 0 Uteroglobin family zf-C2H2 PF00096.21 ESA06603.1 - 0.051 13.9 7.8 0.24 11.8 5.4 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.1 ESA06603.1 - 0.16 12.2 7.8 0.72 10.2 5.4 2.2 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.1 ESA06603.1 - 0.47 10.8 7.7 2 8.9 5.4 2.2 1 0 0 1 1 1 0 C2H2-type zinc finger Abhydrolase_3 PF07859.8 ESA06608.1 - 0.025 14.1 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Metallophos PF00149.23 ESA06608.1 - 0.08 12.3 0.2 0.099 12.0 0.1 1.3 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase F-box-like PF12937.2 ESA06609.1 - 0.0079 15.8 0.7 0.015 15.0 0.1 1.8 2 0 0 2 2 2 1 F-box-like Methyltransf_23 PF13489.1 ESA06610.1 - 1.4e-16 60.6 0.0 2.3e-16 59.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA06610.1 - 2e-15 57.0 0.0 4.1e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06610.1 - 9.6e-13 47.9 0.0 8.4e-12 44.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA06610.1 - 2.3e-10 40.7 0.0 5.3e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA06610.1 - 1.3e-09 37.5 0.0 3.7e-09 36.0 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA06610.1 - 5e-09 36.5 0.0 1.6e-08 34.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA06610.1 - 6.1e-09 36.4 0.0 5.6e-08 33.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA06610.1 - 2.8e-06 26.5 0.0 9e-06 24.8 0.0 1.9 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_29 PF03141.11 ESA06610.1 - 2.3e-05 22.9 0.1 0.00019 19.9 0.0 2.3 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_26 PF13659.1 ESA06610.1 - 2.7e-05 24.1 0.0 7.5e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA06610.1 - 0.00027 20.3 0.0 0.00058 19.2 0.0 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.6 ESA06610.1 - 0.0015 17.2 0.1 0.0031 16.2 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) MTS PF05175.9 ESA06610.1 - 0.0017 17.7 0.0 0.0033 16.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.13 ESA06610.1 - 0.0036 16.5 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.15 ESA06610.1 - 0.0091 15.1 0.0 0.02 13.9 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.10 ESA06610.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase FtsJ PF01728.14 ESA06610.1 - 0.031 14.2 0.0 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.8 ESA06610.1 - 0.11 11.6 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SR-25 PF10500.4 ESA06610.1 - 2.2 7.6 8.7 3.8 6.9 6.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase_Tyr PF07714.12 ESA06611.1 - 1.8e-05 23.9 0.1 2e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06611.1 - 0.00029 20.0 0.3 0.00039 19.6 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinesin PF00225.18 ESA06612.1 - 7.5e-78 261.5 0.8 1e-77 261.1 0.6 1.1 1 0 0 1 1 1 1 Kinesin motor domain CBFD_NFYB_HMF PF00808.18 ESA06613.1 - 3.7e-05 23.6 0.1 4.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.1 ESA06613.1 - 0.00016 21.6 1.2 0.00026 20.9 0.8 1.4 1 1 0 1 1 1 1 Centromere kinetochore component W Histone PF00125.19 ESA06613.1 - 0.031 14.3 1.1 0.07 13.2 0.8 1.6 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 AAA_32 PF13654.1 ESA06613.1 - 0.035 12.7 0.2 0.037 12.6 0.1 1.1 1 0 0 1 1 1 0 AAA domain DUF910 PF06014.6 ESA06615.1 - 0.081 12.8 0.6 0.085 12.7 0.4 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) AAA_35 PF14516.1 ESA06616.1 - 2e-13 49.7 0.2 1.4e-12 46.9 0.1 2.3 1 1 0 1 1 1 1 AAA-like domain Arch_ATPase PF01637.13 ESA06616.1 - 5.4e-06 26.2 0.2 1.7e-05 24.6 0.2 1.9 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ESA06616.1 - 6.1e-06 26.1 0.3 4.2e-05 23.4 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA06616.1 - 8.6e-05 22.7 0.0 0.00022 21.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA06616.1 - 0.00016 21.7 0.2 0.0071 16.3 0.2 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA06616.1 - 0.00019 21.5 0.0 0.00065 19.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.5 ESA06616.1 - 0.0024 17.1 0.0 0.0057 15.8 0.0 1.6 1 0 0 1 1 1 1 Chromatin associated protein KTI12 MobB PF03205.9 ESA06616.1 - 0.023 14.4 0.1 0.56 9.8 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF815 PF05673.8 ESA06616.1 - 0.034 13.0 1.2 0.058 12.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_17 PF13207.1 ESA06616.1 - 0.062 14.1 2.8 1 10.1 0.0 3.5 3 1 0 3 3 3 0 AAA domain AAA_29 PF13555.1 ESA06616.1 - 0.081 12.4 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DivIC PF04977.10 ESA06616.1 - 0.087 12.3 2.9 0.28 10.7 2.0 1.8 1 0 0 1 1 1 0 Septum formation initiator AAA_33 PF13671.1 ESA06616.1 - 0.1 12.4 0.1 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Cys_Met_Meta_PP PF01053.15 ESA06617.1 - 1.8e-25 89.0 0.1 2.2e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mid2 PF04478.7 ESA06620.1 - 0.00048 19.5 0.2 0.00053 19.4 0.1 1.1 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 ESA06620.1 - 0.00067 18.9 6.2 0.0031 16.7 3.3 2.3 2 1 0 2 2 2 1 Transmembrane alpha-helix domain Glycophorin_A PF01102.13 ESA06620.1 - 0.0048 16.6 0.0 0.0065 16.2 0.0 1.2 1 0 0 1 1 1 1 Glycophorin A DUF912 PF06024.7 ESA06620.1 - 0.011 15.7 0.1 0.012 15.6 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3827 PF12877.2 ESA06620.1 - 0.044 11.8 0.1 0.053 11.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Protocadherin PF08374.6 ESA06620.1 - 0.07 12.7 0.1 0.085 12.4 0.1 1.1 1 0 0 1 1 1 0 Protocadherin ATP1G1_PLM_MAT8 PF02038.11 ESA06620.1 - 0.075 12.0 3.5 0.13 11.2 2.4 1.3 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Adeno_E3_CR2 PF02439.10 ESA06620.1 - 0.43 10.1 7.6 0.75 9.3 5.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PsbJ PF01788.12 ESA06620.1 - 10 5.7 7.9 25 4.5 5.5 1.6 1 1 0 1 1 1 0 PsbJ Pkinase PF00069.20 ESA06621.1 - 2.2e-32 112.2 0.0 2.6e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06621.1 - 2.8e-27 95.4 0.0 3.3e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA06621.1 - 0.00024 20.9 0.0 0.00032 20.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA06621.1 - 0.00027 19.9 0.0 0.00037 19.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA06621.1 - 0.0016 17.8 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA06621.1 - 0.0043 16.1 0.0 0.0062 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA06621.1 - 0.0056 15.9 0.1 0.024 13.8 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.15 ESA06621.1 - 0.047 13.2 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.6 ESA06621.1 - 0.053 12.3 0.0 0.091 11.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 UBN_AB PF14075.1 ESA06623.1 - 2.7e-18 66.4 2.7 2.7e-18 66.4 1.9 3.1 3 1 0 3 3 3 1 Ubinuclein conserved middle domain HUN PF08729.5 ESA06623.1 - 1.8e-09 37.3 0.1 4.5e-09 36.0 0.1 1.8 1 0 0 1 1 1 1 HPC2 and ubinuclein domain KfrA_N PF11740.3 ESA06623.1 - 0.0081 16.5 0.9 0.026 14.9 0.1 2.2 2 0 0 2 2 2 1 Plasmid replication region DNA-binding N-term DUF1682 PF07946.9 ESA06623.1 - 1.4 7.6 9.7 3.1 6.5 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ndc1_Nup PF09531.5 ESA06623.1 - 2.4 6.4 10.5 0.24 9.7 3.2 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.7 ESA06623.1 - 5.7 6.7 13.9 0.093 12.6 1.9 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3370 PF11850.3 ESA06624.1 - 0.057 11.8 0.0 0.057 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3370) RRM_5 PF13893.1 ESA06625.1 - 0.0001 22.0 0.0 0.00019 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA06625.1 - 0.00084 18.9 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) R3H PF01424.17 ESA06625.1 - 0.0015 18.1 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 R3H domain SUZ-C PF12901.2 ESA06625.1 - 0.019 14.5 0.5 0.048 13.3 0.4 1.7 1 0 0 1 1 1 0 SUZ-C motif RRM_6 PF14259.1 ESA06625.1 - 0.045 13.7 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SAM_1 PF00536.25 ESA06626.1 - 0.041 14.0 0.5 0.11 12.7 0.1 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Sel1 PF08238.7 ESA06627.1 - 3.4e-140 453.4 58.3 1e-10 41.8 1.4 19.1 19 0 0 19 19 19 19 Sel1 repeat TPR_6 PF13174.1 ESA06627.1 - 1.4e-18 65.9 23.0 0.024 15.0 0.0 10.3 11 1 0 11 11 11 6 Tetratricopeptide repeat TrmB PF01978.14 ESA06627.1 - 5.3e-06 26.0 0.0 30 4.4 0.0 6.3 6 0 0 6 6 6 0 Sugar-specific transcriptional regulator TrmB S10_plectin PF03501.10 ESA06627.1 - 1.1e-05 25.1 0.0 21 5.0 0.0 5.8 5 1 1 6 6 6 0 Plectin/S10 domain RQC PF09382.5 ESA06627.1 - 0.0017 18.0 10.7 15 5.3 0.0 7.1 5 1 1 7 7 7 2 RQC domain Orthopox_F14 PF06076.7 ESA06627.1 - 0.0052 16.8 0.1 28 4.8 0.0 4.9 5 0 0 5 5 5 0 Orthopoxvirus F14 protein Glycos_trans_3N PF02885.12 ESA06627.1 - 0.058 12.9 0.3 74 3.0 0.0 4.2 5 0 0 5 5 5 0 Glycosyl transferase family, helical bundle domain Sel1 PF08238.7 ESA06628.1 - 5.6e-50 166.6 20.7 9.3e-09 35.6 0.1 7.1 7 0 0 7 7 7 7 Sel1 repeat B-block_TFIIIC PF04182.7 ESA06628.1 - 0.0003 20.5 0.6 10 6.0 0.0 3.4 3 1 0 3 3 3 3 B-block binding subunit of TFIIIC DEP PF00610.16 ESA06628.1 - 0.061 13.0 0.1 67 3.3 0.0 3.2 3 0 0 3 3 3 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TPR_20 PF14561.1 ESA06628.1 - 0.091 12.8 3.2 8.6 6.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat S10_plectin PF03501.10 ESA06628.1 - 0.13 12.1 0.5 40 4.1 0.0 3.0 3 0 0 3 3 3 0 Plectin/S10 domain DUF2717 PF10911.3 ESA06628.1 - 0.3 10.6 5.8 1.4 8.4 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2717) DUF2235 PF09994.4 ESA06628.1 - 0.78 9.0 2.8 53 3.0 0.0 3.1 1 1 1 3 3 3 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_6 PF13174.1 ESA06628.1 - 1.5 9.4 7.6 1.2 9.7 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat PBP1_TM PF14812.1 ESA06634.1 - 2.8 8.3 6.6 5.6 7.3 0.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IFT20 PF14931.1 ESA06634.1 - 2.9 7.8 9.1 8.1 6.3 2.5 2.4 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 N-SET PF11764.3 ESA06634.1 - 5.1 6.9 9.8 0.16 11.8 0.3 2.1 1 1 1 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component N DUF4611 PF15387.1 ESA06635.1 - 0.011 15.8 0.4 0.016 15.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CortBP2 PF09727.4 ESA06635.1 - 0.12 11.8 1.4 0.14 11.6 1.0 1.1 1 0 0 1 1 1 0 Cortactin-binding protein-2 F-box-like PF12937.2 ESA06636.1 - 1.1e-05 25.0 4.1 3.3e-05 23.5 2.8 1.8 1 0 0 1 1 1 1 F-box-like zf-C2H2 PF00096.21 ESA06637.1 - 2.3e-13 49.6 7.9 6.8e-07 29.2 1.3 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA06637.1 - 4.2e-12 45.7 9.0 1.4e-06 28.2 0.1 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA06637.1 - 6.8e-09 35.4 10.3 1.8e-05 24.7 1.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.7 ESA06637.1 - 5.3e-05 23.2 0.4 0.00012 22.0 0.3 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.1 ESA06637.1 - 7.7e-05 22.2 2.8 0.0084 15.7 0.3 2.5 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.3 ESA06637.1 - 0.00054 20.0 1.3 0.008 16.2 0.2 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 ESA06637.1 - 0.0015 18.2 1.4 0.54 10.0 0.0 2.6 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.1 ESA06637.1 - 0.024 14.5 3.7 0.73 9.8 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 ESA06637.1 - 0.24 11.6 5.5 0.25 11.5 0.3 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Pkinase_Tyr PF07714.12 ESA06638.1 - 0.058 12.4 0.0 0.058 12.4 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase BTB PF00651.26 ESA06639.1 - 5e-14 52.2 0.1 9.8e-14 51.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA06639.1 - 2.4e-06 27.3 2.9 2.4e-05 24.0 0.2 3.4 2 1 1 3 3 3 1 BTB And C-terminal Kelch Glyco_hydro_63 PF03200.11 ESA06640.1 - 1.1e-105 354.2 0.0 1.3e-105 354.0 0.0 1.0 1 0 0 1 1 1 1 Mannosyl oligosaccharide glucosidase YajC PF02699.10 ESA06642.1 - 0.11 12.1 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit RHD3 PF05879.7 ESA06643.1 - 0.13 10.2 1.4 0.13 10.1 1.0 1.0 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) E1_DerP2_DerF2 PF02221.10 ESA06644.1 - 1.5e-11 44.7 0.4 1.8e-11 44.4 0.3 1.0 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 ESA06644.1 - 1.4e-07 31.5 0.5 2.1e-07 31.0 0.3 1.2 1 0 0 1 1 1 1 ML-like domain Trichoplein PF13868.1 ESA06645.1 - 0.086 11.2 19.0 0.35 9.2 0.1 2.1 2 0 0 2 2 2 0 Tumour suppressor, Mitostatin Pro-NT_NN PF07421.6 ESA06645.1 - 0.089 12.2 0.8 0.17 11.3 0.5 1.5 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor Pkinase PF00069.20 ESA06646.1 - 1.9e-37 128.8 0.0 3.8e-37 127.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06646.1 - 2.2e-33 115.4 0.0 2.7e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA06646.1 - 0.097 12.0 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 RIO1 family APH PF01636.18 ESA06646.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MIR PF02815.14 ESA06647.1 - 0.0028 17.2 0.1 0.019 14.4 0.1 2.3 1 1 0 1 1 1 1 MIR domain HNOB PF07700.10 ESA06647.1 - 0.089 12.3 0.7 11 5.5 0.0 2.2 1 1 1 2 2 2 0 Heme NO binding Phosphodiest PF01663.17 ESA06651.1 - 1.1e-78 265.0 0.6 1.3e-78 264.8 0.4 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 ESA06651.1 - 3e-07 29.9 0.2 0.02 14.1 0.0 3.1 2 1 1 3 3 3 3 Sulfatase PglZ PF08665.7 ESA06651.1 - 0.0073 15.9 0.0 0.15 11.6 0.0 2.5 2 1 1 3 3 3 1 PglZ domain Vps35 PF03635.12 ESA06653.1 - 2.9e-152 508.5 0.1 3.3e-152 508.3 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 PP28 PF10252.4 ESA06654.1 - 1.6e-25 88.9 16.7 1.6e-25 88.9 11.6 2.0 2 0 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 AUX_IAA PF02309.11 ESA06654.1 - 0.13 11.9 8.3 0.19 11.4 5.8 1.3 1 0 0 1 1 1 0 AUX/IAA family F-box-like PF12937.2 ESA06656.1 - 8.3e-06 25.4 2.0 8.3e-06 25.4 1.4 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA06656.1 - 0.069 12.8 1.0 0.47 10.1 0.2 2.6 2 1 0 2 2 2 0 F-box domain Herpes_IE68 PF02479.11 ESA06656.1 - 0.077 12.2 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus immediate early protein PRESAN PF09687.5 ESA06656.1 - 0.53 10.3 4.2 1.2 9.1 2.3 2.2 1 1 0 1 1 1 0 Plasmodium RESA N-terminal WD40 PF00400.27 ESA06657.1 - 6.1e-18 63.9 4.5 4.9e-09 35.7 0.8 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat eIF2A PF08662.6 ESA06657.1 - 1.1e-05 25.1 0.1 2.1e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 ESA06657.1 - 0.00026 20.5 0.0 0.71 9.5 0.0 2.4 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.2 ESA06657.1 - 0.003 17.2 0.3 1.7 8.3 0.2 2.2 1 1 1 2 2 2 2 Transcription factor IIIC subunit delta N-term SGL PF08450.7 ESA06657.1 - 0.0039 16.6 0.1 0.032 13.6 0.0 1.9 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region DPPIV_N PF00930.16 ESA06657.1 - 0.0041 15.7 0.2 0.035 12.7 0.1 1.9 1 1 1 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Apc4_WD40 PF12894.2 ESA06657.1 - 0.0091 15.4 0.0 0.22 11.0 0.0 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.1 ESA06657.1 - 0.048 12.7 0.1 0.54 9.3 0.0 2.3 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal SdiA-regulated PF06977.6 ESA06657.1 - 0.053 12.4 0.0 0.063 12.2 0.0 1.1 1 0 0 1 1 1 0 SdiA-regulated DUF1513 PF07433.6 ESA06657.1 - 0.061 12.2 0.0 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) CPSF_A PF03178.10 ESA06657.1 - 0.12 11.4 0.0 0.25 10.3 0.0 1.5 1 1 0 1 1 1 0 CPSF A subunit region BTB PF00651.26 ESA06658.1 - 5.3e-19 68.2 0.1 9.1e-19 67.4 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA06658.1 - 1.1e-05 25.2 1.2 0.00056 19.7 0.1 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA06658.1 - 0.0033 16.6 0.2 0.0037 16.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Skp1_POZ PF03931.10 ESA06658.1 - 0.11 12.6 0.1 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Septin PF00735.13 ESA06660.1 - 8.1e-79 264.5 1.6 1e-78 264.2 1.1 1.0 1 0 0 1 1 1 1 Septin DRMBL PF07522.9 ESA06660.1 - 0.02 14.9 0.0 0.094 12.7 0.0 2.1 2 1 1 3 3 3 0 DNA repair metallo-beta-lactamase CST-I PF06002.7 ESA06662.1 - 0.021 14.1 0.1 0.025 13.8 0.1 1.1 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) zf-HC5HC2H_2 PF13832.1 ESA06664.1 - 0.056 13.4 2.8 0.21 11.5 0.2 2.4 2 0 0 2 2 2 0 PHD-zinc-finger like domain GDPD PF03009.12 ESA06664.1 - 0.43 10.0 4.5 3 7.2 0.5 2.4 2 1 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Inhibitor_I24 PF10465.4 ESA06667.1 - 0.033 13.9 0.8 0.04 13.6 0.5 1.2 1 0 0 1 1 1 0 PinA peptidase inhibitor Imm32 PF15579.1 ESA06667.1 - 0.093 12.3 0.2 0.2 11.2 0.1 1.7 1 1 1 2 2 2 0 Immunity protein 32 SYF2 PF08231.7 ESA06671.1 - 7.5e-49 165.7 20.2 7.5e-49 165.7 14.0 1.5 2 0 0 2 2 2 1 SYF2 splicing factor AAA_28 PF13521.1 ESA06671.1 - 0.12 12.3 3.3 0.13 12.1 1.3 1.7 1 1 0 2 2 2 0 AAA domain AT_hook PF02178.14 ESA06672.1 - 1.8 8.5 16.7 0.71 9.7 0.5 4.1 3 0 0 3 3 3 0 AT hook motif F-box-like PF12937.2 ESA06673.1 - 0.026 14.2 0.2 0.061 13.0 0.1 1.6 1 0 0 1 1 1 0 F-box-like FAM178 PF14816.1 ESA06674.1 - 0.12 11.1 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 Cys_rich_KTR PF14205.1 ESA06675.1 - 0.3 10.5 2.2 11 5.5 0.0 2.8 3 0 0 3 3 3 0 Cysteine-rich KTR SAM_PNT PF02198.11 ESA06678.1 - 0.0016 18.1 0.0 0.0035 17.0 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PepX_N PF09168.5 ESA06679.1 - 0.0087 16.3 0.5 0.063 13.5 0.0 2.1 2 0 0 2 2 2 1 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Sel1 PF08238.7 ESA06680.1 - 9e-22 77.0 7.5 8e-08 32.6 0.7 4.9 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA06680.1 - 0.052 14.0 0.3 7.7 7.2 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4285 PF14113.1 ESA06681.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4285) DUF771 PF05595.6 ESA06681.1 - 0.03 14.2 0.2 0.05 13.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF771) ApoB100_C PF12491.3 ESA06681.1 - 0.14 11.8 1.6 0.98 9.1 0.6 2.4 1 1 1 2 2 2 0 Apolipoprotein B100 C terminal DUF3317 PF11779.3 ESA06683.1 - 0.00036 19.8 0.3 0.00054 19.3 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3317) zf-met PF12874.2 ESA06684.1 - 1.5e-06 28.1 1.7 1.5e-06 28.1 1.2 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.4 ESA06684.1 - 0.0019 17.7 0.2 0.0029 17.1 0.2 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.6 ESA06684.1 - 0.018 14.3 0.6 0.032 13.4 0.4 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like HSP70 PF00012.15 ESA06686.1 - 0.00011 20.2 0.0 0.00067 17.7 0.0 2.0 1 1 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.15 ESA06686.1 - 0.00045 19.6 0.0 0.0078 15.5 0.0 2.6 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family MreB_Mbl PF06723.8 ESA06686.1 - 0.00051 18.7 0.0 0.05 12.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein TRAPPC-Trs85 PF12739.2 ESA06687.1 - 1e-108 363.7 7.3 6.3e-108 361.0 5.1 2.1 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_2 PF07719.12 ESA06687.1 - 0.031 14.1 0.6 1.2 9.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L35Ae PF01247.13 ESA06688.1 - 0.011 15.5 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L35Ae GATase_5 PF13507.1 ESA06690.1 - 1.7e-102 341.8 0.0 2.5e-102 341.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 ESA06690.1 - 3.9e-40 137.3 0.1 9.5e-23 80.8 0.0 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 ESA06690.1 - 2.4e-26 91.8 0.2 3e-25 88.2 0.0 2.4 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Band_7 PF01145.20 ESA06691.1 - 5.5e-25 88.3 1.2 8e-25 87.7 0.8 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF3399 PF11879.3 ESA06692.1 - 0.12 12.6 0.4 0.13 12.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) Dus PF01207.12 ESA06693.1 - 2.7e-55 187.3 0.0 6.4e-55 186.1 0.0 1.5 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 ESA06693.1 - 0.52 10.0 17.1 0.038 13.6 4.4 3.1 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Zn_clus PF00172.13 ESA06694.1 - 3.6e-07 29.9 13.9 6.4e-07 29.1 9.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIRM PF04433.12 ESA06695.1 - 4.3e-07 29.9 0.0 1.2e-06 28.4 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain U1snRNP70_N PF12220.3 ESA06696.1 - 0.017 15.4 0.5 1.5 9.2 0.0 2.9 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AAA PF00004.24 ESA06697.1 - 4.7e-14 52.7 0.0 8.1e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA06697.1 - 1.3e-05 25.9 0.8 0.00013 22.7 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESA06697.1 - 0.00027 20.9 0.0 0.00049 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA06697.1 - 0.0013 18.9 0.2 0.01 16.0 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA06697.1 - 0.0075 15.9 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA06697.1 - 0.022 14.6 2.9 0.052 13.4 0.0 2.8 3 1 0 3 3 3 0 AAA domain AAA_2 PF07724.9 ESA06697.1 - 0.025 14.4 0.0 0.068 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 ESA06697.1 - 0.031 14.6 3.8 0.032 14.5 0.0 2.7 3 1 0 3 3 3 0 AAA domain Bac_DnaA PF00308.13 ESA06697.1 - 0.032 13.8 0.2 0.094 12.3 0.2 1.7 1 1 0 1 1 1 0 Bacterial dnaA protein RNA_helicase PF00910.17 ESA06697.1 - 0.035 14.2 0.0 0.34 11.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.12 ESA06697.1 - 0.069 12.5 0.0 0.46 9.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.1 ESA06697.1 - 0.073 12.6 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 ESA06697.1 - 0.095 12.4 0.1 2.7 7.6 0.0 2.6 2 1 1 3 3 3 0 NTPase DUF258 PF03193.11 ESA06697.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 RuvB_N PF05496.7 ESA06697.1 - 0.13 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 ESA06697.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Methyltransf_11 PF08241.7 ESA06699.1 - 1.7e-14 54.0 0.0 2.5e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06699.1 - 4.9e-12 45.6 0.0 1.3e-11 44.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA06699.1 - 3.2e-09 36.6 0.0 4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA06699.1 - 1.1e-08 35.3 0.0 1.8e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA06699.1 - 3.9e-07 30.4 0.0 8.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA06699.1 - 6.1e-06 25.4 0.0 1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESA06699.1 - 1.5e-05 25.5 0.0 5.4e-05 23.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA06699.1 - 0.00073 18.7 0.0 0.0016 17.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.13 ESA06699.1 - 0.0011 18.2 0.0 0.0012 18.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 ESA06699.1 - 0.002 18.1 0.0 0.0036 17.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA06699.1 - 0.0036 16.6 0.0 0.0062 15.9 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.9 ESA06699.1 - 0.012 14.7 0.0 4 6.5 0.0 2.0 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_29 PF03141.11 ESA06699.1 - 0.015 13.6 0.0 0.08 11.2 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Sel1 PF08238.7 ESA06701.1 - 5.6e-54 179.3 4.0 2.9e-11 43.6 0.1 6.2 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA06701.1 - 0.00063 19.5 13.8 0.15 12.0 0.6 5.3 3 3 2 5 5 5 3 MIT (microtubule interacting and transport) domain MTBP_C PF14920.1 ESA06701.1 - 0.68 9.3 1.7 18 4.6 0.0 3.3 4 1 0 4 4 4 0 MDM2-binding ApoB100_C PF12491.3 ESA06703.1 - 0.041 13.5 1.5 0.041 13.5 1.0 2.1 1 1 1 2 2 2 0 Apolipoprotein B100 C terminal DDE_1 PF03184.14 ESA06703.1 - 0.075 12.1 0.0 0.11 11.6 0.0 1.3 1 1 0 1 1 1 0 DDE superfamily endonuclease BTB PF00651.26 ESA06706.1 - 1.2e-17 63.8 1.1 2.3e-17 62.9 0.8 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA06706.1 - 9.5e-15 54.8 4.2 6.4e-14 52.1 0.1 3.1 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA06706.1 - 0.013 15.3 6.6 0.7 9.7 0.3 3.5 1 1 1 3 3 3 0 BTB And C-terminal Kelch Urm1 PF09138.6 ESA06706.1 - 0.033 14.2 1.1 0.52 10.4 0.1 2.6 2 0 0 2 2 2 0 Urm1 (Ubiquitin related modifier) Pkinase_Tyr PF07714.12 ESA06707.1 - 0.0022 17.0 0.0 0.0069 15.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06707.1 - 0.031 13.4 0.1 0.42 9.7 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain GATA PF00320.22 ESA06708.1 - 5.2e-15 54.4 3.4 1.2e-14 53.3 2.3 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF2039 PF10217.4 ESA06708.1 - 0.014 15.3 1.5 0.26 11.3 0.1 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Auto_anti-p27 PF06677.7 ESA06710.1 - 5.5e-09 35.6 0.1 9.9e-09 34.8 0.0 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) UBN2 PF14223.1 ESA06710.1 - 0.0024 17.6 2.4 0.0038 16.9 1.6 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type SDH_alpha PF03313.10 ESA06710.1 - 0.052 12.5 0.2 0.085 11.8 0.1 1.3 1 0 0 1 1 1 0 Serine dehydratase alpha chain BRCT PF00533.21 ESA06710.1 - 0.13 12.4 1.2 0.76 9.9 0.4 2.4 2 1 1 3 3 3 0 BRCA1 C Terminus (BRCT) domain DUF1664 PF07889.7 ESA06710.1 - 0.26 11.0 6.1 0.52 10.1 3.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Baculo_LEF-11 PF06385.7 ESA06710.1 - 0.29 11.2 4.9 0.65 10.1 3.4 1.7 1 1 0 1 1 1 0 Baculovirus LEF-11 protein PH_11 PF15413.1 ESA06710.1 - 1.4 9.1 5.5 1.8 8.8 2.8 1.8 1 1 1 2 2 2 0 Pleckstrin homology domain ATG13 PF10033.4 ESA06711.1 - 9.6e-24 84.0 0.0 1.1e-23 83.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 13 Acetyltransf_1 PF00583.19 ESA06714.1 - 2.2e-13 50.0 0.0 2.9e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA06714.1 - 3.8e-12 46.1 0.0 5.7e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA06714.1 - 3.7e-09 36.7 0.0 4.5e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA06714.1 - 6.2e-09 35.7 0.0 7.8e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.1 ESA06714.1 - 3e-06 27.7 0.0 0.011 16.3 0.0 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA06714.1 - 0.0012 19.0 0.0 0.0014 18.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA06714.1 - 0.0064 16.4 0.1 0.0069 16.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 ESA06714.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Gag_p12 PF01141.13 ESA06716.1 - 0.39 10.8 2.9 0.7 10.0 0.1 2.2 2 0 0 2 2 2 0 Gag polyprotein, inner coat protein p12 Kelch_5 PF13854.1 ESA06717.1 - 1.3e-06 28.1 0.0 0.003 17.4 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA06717.1 - 0.00034 20.2 0.0 0.078 12.7 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESA06717.1 - 0.0087 15.8 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA06717.1 - 0.02 14.4 0.2 1 8.9 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.1 ESA06717.1 - 0.035 14.3 0.0 1.4 9.2 0.0 2.7 2 1 0 2 2 2 0 Kelch motif Kelch_3 PF13415.1 ESA06717.1 - 0.12 12.5 0.3 0.91 9.7 0.0 2.5 3 0 0 3 3 3 0 Galactose oxidase, central domain zf-RING_2 PF13639.1 ESA06718.1 - 8.5e-15 54.3 6.6 8.5e-15 54.3 4.6 2.0 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 ESA06718.1 - 6.7e-11 42.1 6.8 1.2e-10 41.2 4.7 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA06718.1 - 1.4e-08 34.5 11.1 3.2e-08 33.4 4.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA06718.1 - 5.4e-08 32.3 5.9 5.4e-08 32.3 4.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA06718.1 - 2.6e-07 30.2 4.3 2.6e-07 30.2 3.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA06718.1 - 1.8e-06 27.4 3.4 1.8e-06 27.4 2.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA06718.1 - 3.1e-05 23.7 5.2 8e-05 22.4 3.6 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.3 ESA06718.1 - 0.00076 18.9 1.6 0.0013 18.2 1.1 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 ESA06718.1 - 0.011 15.3 5.1 0.022 14.3 3.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 ESA06718.1 - 0.026 14.5 6.1 0.081 12.9 4.3 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_UBOX PF13445.1 ESA06718.1 - 0.039 13.6 4.5 0.11 12.2 3.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA06718.1 - 0.064 13.1 9.5 0.5 10.2 3.3 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING PHD PF00628.24 ESA06718.1 - 0.49 10.1 6.2 1.3 8.7 4.3 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.6 ESA06718.1 - 0.76 9.8 6.0 1.9 8.5 4.2 1.8 1 1 0 1 1 1 0 RING-like domain FANCL_C PF11793.3 ESA06718.1 - 1.2 9.1 10.4 5 7.1 7.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain tRNA_Me_trans PF03054.11 ESA06719.1 - 3.7e-97 325.0 0.1 4.4e-97 324.8 0.1 1.0 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.9 ESA06719.1 - 0.00041 19.8 0.0 0.00072 19.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.12 ESA06719.1 - 0.0014 17.6 0.0 0.02 13.7 0.0 2.3 2 0 0 2 2 2 1 NAD synthase Asn_synthase PF00733.16 ESA06719.1 - 0.0044 16.5 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.15 ESA06719.1 - 0.029 13.8 0.0 0.086 12.3 0.0 1.7 2 0 0 2 2 2 0 PP-loop family QueC PF06508.8 ESA06719.1 - 0.12 11.6 0.1 0.94 8.7 0.0 2.0 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC EspG PF06872.6 ESA06721.1 - 0.093 11.0 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 EspG protein DUF2191 PF09957.4 ESA06723.1 - 6e-06 25.9 0.1 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2191) Pkinase_Tyr PF07714.12 ESA06726.1 - 6.3e-22 77.8 0.0 9.8e-22 77.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06726.1 - 1.7e-19 69.9 0.1 3.6e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA06726.1 - 0.034 13.1 0.0 0.071 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA06727.1 - 4.1e-41 138.5 8.0 4.2e-08 33.5 0.1 6.3 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA06727.1 - 3.6e-06 27.0 8.7 3.4 8.3 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat GSH-S_N PF02951.9 ESA06727.1 - 0.0024 17.6 0.1 1.7 8.4 0.0 3.1 3 0 0 3 3 3 1 Prokaryotic glutathione synthetase, N-terminal domain TPR_7 PF13176.1 ESA06727.1 - 0.055 13.2 5.1 12 5.9 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat FATC PF02260.15 ESA06727.1 - 0.14 11.6 1.0 5.7 6.4 0.0 2.7 3 0 0 3 3 3 0 FATC domain Leuk-A4-hydro_C PF09127.6 ESA06727.1 - 0.15 11.6 0.9 14 5.2 0.1 3.3 3 0 0 3 3 3 0 Leukotriene A4 hydrolase, C-terminal MIT PF04212.13 ESA06727.1 - 0.17 11.8 10.4 2.2 8.2 0.1 3.9 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ESA06727.1 - 1.1 10.1 5.4 1.8e+02 3.4 0.1 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TMEM107 PF14995.1 ESA06728.1 - 0.18 11.9 2.5 0.36 10.9 1.7 1.5 1 0 0 1 1 1 0 Transmembrane protein Dispanin PF04505.7 ESA06730.1 - 0.14 11.7 0.9 0.37 10.3 0.3 1.7 2 0 0 2 2 2 0 Interferon-induced transmembrane protein RNase_H PF00075.19 ESA06732.1 - 1.6e-09 38.1 0.0 1.7e-08 34.8 0.0 2.7 3 1 0 3 3 3 1 RNase H Macoilin PF09726.4 ESA06733.1 - 0.00014 20.3 5.0 0.00016 20.1 3.5 1.1 1 0 0 1 1 1 1 Transmembrane protein YejG PF13989.1 ESA06733.1 - 0.27 11.3 3.5 0.47 10.5 0.1 2.5 1 1 0 2 2 2 0 YejG-like protein LRR_4 PF12799.2 ESA06733.1 - 0.57 9.8 8.6 1.7 8.3 0.2 3.0 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) V_ATPase_I PF01496.14 ESA06733.1 - 0.66 7.7 7.8 0.83 7.4 5.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.6 ESA06733.1 - 2 7.6 6.7 1.3 8.2 2.7 1.8 2 1 1 3 3 3 0 Allexivirus 40kDa protein KLRAQ PF10205.4 ESA06733.1 - 8.9 6.4 13.4 22 5.1 9.3 1.7 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Sel1 PF08238.7 ESA06735.1 - 5.5e-53 176.2 32.6 2.2e-12 47.2 2.0 7.0 7 0 0 7 7 7 6 Sel1 repeat STE PF02200.11 ESA06735.1 - 0.0039 17.3 7.5 0.16 12.1 0.1 3.3 3 0 0 3 3 3 2 STE like transcription factor TPR_17 PF13431.1 ESA06735.1 - 0.11 12.7 11.4 4.4 7.7 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA06735.1 - 0.13 12.2 0.0 20 5.3 0.0 2.8 2 1 1 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain DUF2971 PF11185.3 ESA06737.1 - 0.4 11.4 5.3 0.46 11.2 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2971) InvH PF04741.7 ESA06737.1 - 0.84 9.4 5.8 0.94 9.3 4.0 1.0 1 0 0 1 1 1 0 InvH outer membrane lipoprotein zf-TRAF PF02176.13 ESA06740.1 - 0.0016 18.7 2.2 0.003 17.8 1.5 1.6 1 0 0 1 1 1 1 TRAF-type zinc finger DUF668 PF05003.7 ESA06741.1 - 0.086 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF668) PIG-S PF10510.4 ESA06742.1 - 5e-131 437.9 13.6 2.5e-119 399.2 5.6 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-glycan biosynthesis class S protein UBA_4 PF14555.1 ESA06742.1 - 0.014 14.9 5.4 0.88 9.1 0.1 3.0 3 0 0 3 3 3 0 UBA-like domain WD40 PF00400.27 ESA06743.1 - 4.9e-48 159.3 18.0 1.9e-08 33.8 0.4 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat PFU PF09070.6 ESA06743.1 - 5.4e-44 148.9 0.3 1.2e-43 147.8 0.2 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.6 ESA06743.1 - 7.1e-44 149.6 8.7 1e-43 149.0 6.0 1.2 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.1 ESA06743.1 - 0.00068 19.3 0.0 1.4 8.7 0.0 4.0 1 1 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.1 ESA06743.1 - 0.0067 16.6 0.1 0.66 10.3 0.0 3.4 3 0 0 3 3 3 1 PQQ-like domain DUF633 PF04816.7 ESA06744.1 - 0.021 14.1 0.1 0.031 13.6 0.1 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF633) PX PF00787.19 ESA06745.1 - 0.085 12.6 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 PX domain DUF1764 PF08576.5 ESA06747.1 - 8 7.2 9.9 2.1 9.1 4.1 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) TLD PF07534.11 ESA06749.1 - 2.8e-12 46.7 1.3 6e-12 45.7 0.9 1.6 1 1 0 1 1 1 1 TLD Sel1 PF08238.7 ESA06750.1 - 4.6e-26 90.6 12.5 3.5e-08 33.8 0.2 6.2 6 0 0 6 6 6 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA06750.1 - 0.00026 20.1 0.0 0.00042 19.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Phage_int_SAM_3 PF14659.1 ESA06750.1 - 0.77 10.0 6.9 0.67 10.2 0.4 2.8 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Pkinase PF00069.20 ESA06753.1 - 0.016 14.3 0.0 0.026 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06753.1 - 0.078 12.0 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase MIR PF02815.14 ESA06756.1 - 0.00029 20.4 0.6 0.0043 16.6 0.1 2.1 1 1 1 2 2 2 2 MIR domain MSV199 PF10553.4 ESA06756.1 - 0.014 15.2 1.2 0.023 14.5 0.7 1.5 1 1 0 1 1 1 0 MSV199 domain RRM_1 PF00076.17 ESA06757.1 - 1.1e-10 40.9 0.2 3.3e-06 26.6 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA06757.1 - 9e-06 25.5 0.0 0.022 14.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PolyA_pol PF01743.15 ESA06757.1 - 0.036 14.2 0.9 0.036 14.2 0.7 2.0 2 0 0 2 2 2 0 Poly A polymerase head domain Collagen_bind_2 PF12904.2 ESA06757.1 - 0.084 12.6 0.9 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase zf-CCHC PF00098.18 ESA06757.1 - 0.18 11.7 1.6 0.33 10.9 1.1 1.5 1 0 0 1 1 1 0 Zinc knuckle KicB PF03882.9 ESA06758.1 - 0.064 11.8 0.1 2.9 6.3 0.0 2.0 1 1 1 2 2 2 0 KicB killing factor DUF2356 PF10189.4 ESA06759.1 - 7.9e-24 83.9 2.4 1.3e-23 83.3 1.7 1.3 1 0 0 1 1 1 1 Conserved protein (DUF2356) HMG_box PF00505.14 ESA06762.1 - 1.2e-05 25.5 0.3 1.9e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06762.1 - 0.00062 20.0 0.2 0.001 19.4 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain Herpes_Helicase PF02689.9 ESA06763.1 - 0.00026 18.9 0.0 0.00031 18.6 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA06763.1 - 0.0075 16.3 0.0 0.0078 16.3 0.0 1.2 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Kelch_4 PF13418.1 ESA06764.1 - 1.7e-10 40.4 5.0 0.00012 21.8 0.1 3.7 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA06764.1 - 1.6e-07 31.2 5.6 1.6e-06 28.1 0.1 3.6 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA06764.1 - 0.00012 21.8 1.4 0.062 13.2 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.1 ESA06764.1 - 0.0016 18.5 6.6 0.56 10.4 0.6 3.8 2 1 1 3 3 3 2 Kelch motif Prominin PF05478.6 ESA06764.1 - 0.1 10.0 0.1 0.13 9.7 0.0 1.1 1 0 0 1 1 1 0 Prominin Kelch_2 PF07646.10 ESA06764.1 - 0.12 12.1 2.8 1.8 8.4 0.0 3.7 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.20 ESA06764.1 - 0.3 10.6 7.1 5.4 6.6 1.5 3.6 3 1 0 3 3 3 0 Kelch motif NADase_NGA PF07461.6 ESA06766.1 - 0.05 12.2 0.0 0.053 12.2 0.0 1.0 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) FWWh PF14922.1 ESA06767.1 - 0.017 14.6 0.2 0.027 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function Spc7 PF08317.6 ESA06768.1 - 0.0045 15.7 12.1 0.0062 15.2 8.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein APG17 PF04108.7 ESA06768.1 - 0.012 14.4 0.1 0.012 14.4 0.0 2.4 2 1 0 2 2 2 0 Autophagy protein Apg17 Reo_sigmaC PF04582.7 ESA06768.1 - 0.086 12.0 0.4 0.4 9.8 0.1 1.6 1 1 0 1 1 1 0 Reovirus sigma C capsid protein SlyX PF04102.7 ESA06768.1 - 0.15 12.4 2.3 0.6 10.5 0.9 2.2 2 0 0 2 2 2 0 SlyX TMCO5 PF14992.1 ESA06768.1 - 0.29 10.2 13.6 0.75 8.8 9.4 1.6 1 1 0 1 1 1 0 TMCO5 family CENP-Q PF13094.1 ESA06768.1 - 3.9 7.4 10.5 0.19 11.7 1.7 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit IncA PF04156.9 ESA06768.1 - 4 6.9 6.5 7 6.1 4.5 1.4 1 0 0 1 1 1 0 IncA protein AAA PF00004.24 ESA06769.1 - 3.5e-17 62.8 0.0 5.3e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA06769.1 - 2.5e-05 24.4 0.7 0.00051 20.1 0.1 2.4 2 1 1 3 3 2 1 AAA domain AAA_16 PF13191.1 ESA06769.1 - 4.3e-05 23.5 0.0 6.8e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 ESA06769.1 - 8.1e-05 22.3 0.3 0.00021 21.0 0.0 1.9 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) Zot PF05707.7 ESA06769.1 - 0.00021 20.8 0.0 0.0039 16.6 0.0 2.1 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_19 PF13245.1 ESA06769.1 - 0.00068 19.3 0.0 0.0012 18.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain Mg_chelatase PF01078.16 ESA06769.1 - 0.0023 17.1 0.1 0.009 15.1 0.0 2.0 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 ESA06769.1 - 0.0049 16.4 0.0 0.0068 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESA06769.1 - 0.0087 15.6 0.1 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA06769.1 - 0.017 14.7 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESA06769.1 - 0.019 14.9 0.1 0.09 12.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain Kinesin PF00225.18 ESA06769.1 - 0.021 13.5 0.0 0.023 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain AAA_17 PF13207.1 ESA06769.1 - 0.024 15.4 0.1 0.043 14.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESA06769.1 - 0.025 14.8 0.1 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ESA06769.1 - 0.039 13.8 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 ESA06769.1 - 0.073 12.1 0.1 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 KaiC Peptidase_C98 PF15499.1 ESA06771.1 - 0.08 12.2 1.3 0.1 11.8 0.9 1.3 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase PPV_E2_N PF00508.12 ESA06771.1 - 0.11 11.6 1.4 0.23 10.6 0.9 1.5 1 0 0 1 1 1 0 E2 (early) protein, N terminal DUF29 PF01724.11 ESA06771.1 - 0.23 11.3 5.7 0.081 12.7 2.1 1.7 1 1 1 2 2 2 0 Domain of unknown function DUF29 Peptidase_C6 PF00851.13 ESA06772.1 - 0.033 12.8 0.5 0.039 12.5 0.4 1.1 1 0 0 1 1 1 0 Helper component proteinase Methyltransf_23 PF13489.1 ESA06774.1 - 0.0011 18.6 0.0 0.0014 18.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA06774.1 - 0.002 18.5 0.0 0.0033 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06774.1 - 0.024 14.2 0.1 0.038 13.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 ESA06774.1 - 0.052 12.9 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FRG1 PF06229.7 ESA06774.1 - 0.14 11.6 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 FRG1-like family PQ-loop PF04193.9 ESA06775.1 - 1.4e-30 104.6 16.5 5.3e-18 64.3 1.9 3.2 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.11 ESA06775.1 - 0.0008 19.2 3.3 0.0008 19.2 2.3 2.9 3 1 0 3 3 3 1 Sugar efflux transporter for intercellular exchange GPI2 PF06432.6 ESA06775.1 - 0.18 11.1 10.6 0.2 10.9 1.8 2.7 2 1 1 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF1422 PF07226.6 ESA06775.1 - 7.3 6.3 11.5 0.82 9.4 2.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1422) NOP5NT PF08156.8 ESA06776.1 - 0.76 9.9 4.3 0.49 10.5 0.7 2.1 2 0 0 2 2 2 0 NOP5NT (NUC127) domain Pkinase_Tyr PF07714.12 ESA06779.1 - 2.1e-14 53.2 0.0 2.6e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06779.1 - 8.2e-09 34.9 1.8 2e-08 33.7 1.2 1.5 1 1 0 1 1 1 1 Protein kinase domain Peptidase_M16 PF00675.15 ESA06780.1 - 2.9e-37 127.7 0.0 4.2e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESA06780.1 - 1.5e-08 34.5 0.0 4.3e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain Lipase_3 PF01764.20 ESA06781.1 - 1.1e-23 83.3 0.0 1.8e-22 79.5 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESA06781.1 - 0.011 15.1 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.15 ESA06781.1 - 0.014 14.9 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA06781.1 - 0.018 14.7 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.9 ESA06781.1 - 0.082 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) FAM86 PF14904.1 ESA06781.1 - 0.083 12.6 0.0 2.1 8.1 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function Abhydrolase_3 PF07859.8 ESA06781.1 - 0.15 11.5 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold RNase_H PF00075.19 ESA06783.1 - 1.1e-05 25.7 0.4 0.049 13.9 0.0 2.2 1 1 1 2 2 2 2 RNase H DUF108 PF01958.13 ESA06783.1 - 0.027 14.6 0.0 0.038 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF108 EF1_GNE PF00736.14 ESA06784.1 - 1.9e-34 117.2 0.7 3.2e-34 116.4 0.5 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 ESA06784.1 - 1.2e-12 47.6 11.4 1.2e-12 47.6 7.9 2.0 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C PF00043.20 ESA06784.1 - 0.0025 17.7 0.9 0.046 13.7 0.0 2.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA06784.1 - 0.0061 17.0 0.1 0.017 15.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain YL1 PF05764.8 ESA06784.1 - 0.025 14.1 4.1 0.027 14.1 2.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein GST_C_2 PF13410.1 ESA06784.1 - 0.034 14.0 0.1 0.32 10.9 0.1 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MinC_N PF05209.8 ESA06784.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain Kin17_mid PF10357.4 ESA06785.1 - 6.2e-49 164.8 0.3 6.2e-49 164.8 0.2 3.5 2 1 1 3 3 3 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 ESA06785.1 - 0.00023 21.1 5.9 0.00073 19.6 4.1 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA06785.1 - 0.00024 21.1 5.7 0.00052 20.1 4.0 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESA06785.1 - 0.003 17.6 2.7 0.013 15.5 1.9 2.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Pkinase PF00069.20 ESA06787.1 - 0.025 13.7 0.1 0.029 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06787.1 - 0.063 12.3 0.0 0.074 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Pox_I6 PF04595.8 ESA06787.1 - 0.092 11.4 0.3 0.096 11.4 0.2 1.1 1 0 0 1 1 1 0 Poxvirus I6-like family Proteasome PF00227.21 ESA06793.1 - 3.2e-50 170.0 0.1 4.1e-50 169.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 ESA06793.1 - 3.8e-13 48.4 0.1 3.8e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal adh_short PF00106.20 ESA06794.1 - 2.5e-17 63.2 0.0 4e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA06794.1 - 8.1e-13 48.7 0.0 1.3e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 ESA06794.1 - 4.3e-10 39.2 0.0 3e-06 26.5 0.0 2.0 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 ESA06794.1 - 0.046 13.7 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 NADH(P)-binding Epimerase PF01370.16 ESA06794.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Aldolase_2 PF10120.4 ESA06794.1 - 0.13 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative aldolase RNase_H PF00075.19 ESA06795.1 - 0.0066 16.7 0.0 0.0069 16.7 0.0 1.1 1 0 0 1 1 1 1 RNase H HMG_box PF00505.14 ESA06796.1 - 9.9e-12 44.9 1.3 1.4e-11 44.4 0.9 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06796.1 - 0.0007 19.9 0.5 0.001 19.3 0.4 1.3 1 0 0 1 1 1 1 HMG-box domain Colicin_Pyocin PF01320.13 ESA06796.1 - 0.0072 16.1 0.0 0.012 15.4 0.0 1.4 1 1 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein HPHLAWLY PF14925.1 ESA06798.1 - 5.4 4.8 7.6 6 4.7 5.3 1.0 1 0 0 1 1 1 0 Domain of unknown function Clathrin PF00637.15 ESA06799.1 - 0.055 13.0 0.4 0.066 12.8 0.3 1.2 1 0 0 1 1 1 0 Region in Clathrin and VPS HBS1_N PF08938.5 ESA06799.1 - 0.074 13.1 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 HBS1 N-terminus Pkinase_Tyr PF07714.12 ESA06800.1 - 1e-25 90.2 0.0 1.5e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06800.1 - 2.3e-23 82.6 0.2 7.3e-23 81.0 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA06800.1 - 0.0027 16.8 0.0 0.0042 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA06800.1 - 0.0038 17.0 1.2 0.0058 16.3 0.9 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Transket_pyr PF02779.19 ESA06802.1 - 2.3e-39 134.7 0.0 3.1e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 ESA06802.1 - 3.7e-34 117.3 0.0 6.5e-34 116.5 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain Methyltransf_11 PF08241.7 ESA06807.1 - 9e-16 58.1 0.0 1.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA06807.1 - 8.7e-14 51.3 0.1 7.8e-13 48.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA06807.1 - 2.7e-12 46.7 0.0 4.9e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA06807.1 - 1.5e-11 44.5 0.0 2.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA06807.1 - 1.9e-09 37.0 0.0 5.9e-09 35.3 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA06807.1 - 2e-09 37.8 0.0 6.5e-09 36.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA06807.1 - 2.4e-08 34.5 0.0 8.9e-07 29.4 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA06807.1 - 7.2e-05 22.5 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.11 ESA06807.1 - 0.00035 19.0 6.5 0.0086 14.4 4.5 2.6 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.12 ESA06807.1 - 0.0017 17.4 0.0 0.037 13.0 0.0 2.6 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA06807.1 - 0.002 18.1 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA06807.1 - 0.0033 16.8 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CheR PF01739.13 ESA06807.1 - 0.025 13.8 0.0 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TcdB_N PF12918.2 ESA06810.1 - 0.0022 18.0 1.2 0.0026 17.8 0.8 1.1 1 0 0 1 1 1 1 TcdB toxin N-terminal helical domain DUF717 PF05338.7 ESA06810.1 - 0.032 14.1 2.6 0.38 10.7 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF717) DUF2248 PF10005.4 ESA06811.1 - 0.014 14.3 2.7 0.017 14.0 1.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2248) Ndc80_HEC PF03801.8 ESA06812.1 - 0.002 17.5 0.1 0.0028 17.1 0.0 1.2 1 1 0 1 1 1 1 HEC/Ndc80p family DUF3641 PF12345.3 ESA06813.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) AAA_11 PF13086.1 ESA06814.1 - 7.4e-16 58.4 0.3 1e-15 58.0 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA06814.1 - 2.2e-07 30.5 0.0 3.8e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain UvrD-helicase PF00580.16 ESA06814.1 - 1.9e-06 27.4 4.1 3.6e-06 26.5 2.8 1.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.4 ESA06814.1 - 4.3e-06 25.9 0.2 4.3e-06 25.9 0.1 2.6 1 1 1 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 ESA06814.1 - 0.00053 20.2 0.4 0.002 18.3 0.3 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA06814.1 - 0.00058 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.1 ESA06814.1 - 0.00091 18.8 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESA06814.1 - 0.005 16.7 2.4 0.027 14.3 1.6 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit KaiC PF06745.8 ESA06814.1 - 0.012 14.7 0.4 0.14 11.2 0.0 2.4 3 0 0 3 3 3 0 KaiC AAA_22 PF13401.1 ESA06814.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 ESA06814.1 - 0.06 12.5 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.1 ESA06814.1 - 0.074 12.4 0.1 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESA06814.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 ESA06814.1 - 0.12 13.2 3.1 0.74 10.6 2.0 2.4 1 1 0 1 1 1 0 AAA domain DUF3640 PF12342.3 ESA06814.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3640) AAA_18 PF13238.1 ESA06814.1 - 0.14 12.4 3.3 0.42 10.9 2.0 2.3 1 1 0 1 1 1 0 AAA domain XdhC_C PF13478.1 ESA06814.1 - 0.16 12.3 0.0 0.5 10.6 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain FAR1 PF03101.10 ESA06816.1 - 6.9e-11 42.5 3.1 1.2e-10 41.6 2.2 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain MTHFR PF02219.12 ESA06817.1 - 3.8e-116 387.1 0.0 4.7e-116 386.8 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PASTA PF03793.14 ESA06817.1 - 0.17 11.5 0.0 6.5 6.4 0.0 2.5 2 0 0 2 2 2 0 PASTA domain WD40 PF00400.27 ESA06818.1 - 2e-11 43.3 13.3 1.6e-05 24.6 0.0 6.0 6 1 0 6 6 6 3 WD domain, G-beta repeat F-box-like PF12937.2 ESA06818.1 - 3.1e-11 42.7 0.5 5.9e-11 41.9 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA06818.1 - 1.2e-07 31.2 0.0 2.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain Coatomer_WDAD PF04053.9 ESA06818.1 - 0.078 11.7 0.2 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Coatomer WD associated region TLD PF07534.11 ESA06819.1 - 0.0061 16.5 3.0 0.013 15.4 2.1 1.5 1 1 0 1 1 1 1 TLD PROCT PF08084.6 ESA06819.1 - 0.036 13.7 0.2 0.04 13.6 0.1 1.1 1 0 0 1 1 1 0 PROCT (NUC072) domain zf-CGNR PF11706.3 ESA06819.1 - 0.13 11.8 1.0 0.38 10.2 0.1 1.9 2 0 0 2 2 2 0 CGNR zinc finger CDC45 PF02724.9 ESA06820.1 - 0.039 11.9 11.6 0.055 11.5 8.0 1.3 1 0 0 1 1 1 0 CDC45-like protein MIP-T3 PF10243.4 ESA06821.1 - 0.29 9.5 20.8 0.33 9.3 14.4 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 NPR3 PF03666.8 ESA06821.1 - 0.82 8.1 6.7 1 7.7 4.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CAF-1_p150 PF11600.3 ESA06821.1 - 1 8.6 20.6 1.3 8.3 14.2 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Daxx PF03344.10 ESA06821.1 - 1.5 7.2 17.1 1.6 7.1 11.9 1.0 1 0 0 1 1 1 0 Daxx Family NUMOD3 PF07460.6 ESA06822.1 - 0.76 9.7 3.8 0.34 10.8 0.6 2.0 2 0 0 2 2 2 0 NUMOD3 motif (2 copies) Pkinase PF00069.20 ESA06824.1 - 1.1e-27 96.8 0.1 1.2e-27 96.7 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06824.1 - 4.3e-27 94.8 0.0 4.6e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA06824.1 - 0.0015 17.6 0.0 0.0017 17.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA06824.1 - 0.0088 15.2 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA06824.1 - 0.017 14.4 0.1 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESA06824.1 - 0.028 13.3 0.0 0.033 13.1 0.0 1.0 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESA06824.1 - 0.069 12.4 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Sel1 PF08238.7 ESA06825.1 - 4.3e-18 65.3 2.7 8.4e-06 26.2 0.2 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_2 PF07719.12 ESA06825.1 - 2.1 8.4 0.0 2.1 8.4 0.0 4.0 5 1 0 5 5 5 0 Tetratricopeptide repeat Grp1_Fun34_YaaH PF01184.14 ESA06827.1 - 3.3e-44 150.7 21.9 3.6e-44 150.5 15.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4153 PF13687.1 ESA06827.1 - 6.4 6.2 19.5 0.2 11.1 8.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4153) ACBP PF00887.14 ESA06828.1 - 4.5e-11 42.2 1.0 7.8e-11 41.4 0.7 1.3 1 1 0 1 1 1 1 Acyl CoA binding protein Xan_ur_permease PF00860.15 ESA06829.1 - 2.2e-31 108.7 31.5 3.4e-30 104.8 21.8 2.3 2 1 0 2 2 2 1 Permease family Rad10 PF03834.9 ESA06830.1 - 0.071 12.8 0.0 0.073 12.7 0.0 1.1 1 0 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Mad3_BUB1_I PF08311.7 ESA06831.1 - 0.054 13.2 3.4 0.14 11.9 0.1 2.6 2 1 1 3 3 3 0 Mad3/BUB1 homology region 1 Ada3 PF10198.4 ESA06831.1 - 0.1 12.3 0.5 0.75 9.5 0.0 2.3 2 1 0 2 2 2 0 Histone acetyltransferases subunit 3 MULE PF10551.4 ESA06832.1 - 0.11 12.6 0.2 0.24 11.5 0.2 1.6 1 0 0 1 1 1 0 MULE transposase domain AAA PF00004.24 ESA06833.1 - 9.7e-06 25.8 0.5 0.00033 20.8 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA06833.1 - 5.7e-05 22.8 0.0 0.00019 21.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA06833.1 - 0.00062 19.6 0.2 0.0022 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 ESA06833.1 - 0.00076 19.9 0.0 0.0026 18.2 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 ESA06833.1 - 0.0011 19.1 0.0 0.0074 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 ESA06833.1 - 0.019 14.6 0.3 0.13 11.9 0.0 2.4 3 0 0 3 3 3 0 NACHT domain Sigma54_activ_2 PF14532.1 ESA06833.1 - 0.027 14.5 0.0 0.073 13.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SE PF00437.15 ESA06833.1 - 0.03 13.2 0.0 0.06 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Viral_helicase1 PF01443.13 ESA06833.1 - 0.047 13.1 0.0 0.093 12.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 ESA06833.1 - 0.077 13.1 0.0 0.22 11.7 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 ESA06833.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Eapp_C PF10238.4 ESA06834.1 - 0.32 10.9 5.9 0.63 9.9 4.1 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein NST1 PF13945.1 ESA06834.1 - 0.33 10.9 8.6 0.52 10.3 5.9 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator SAM_1 PF00536.25 ESA06835.1 - 1.3e-07 31.6 0.0 2.1e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA06835.1 - 0.00015 21.5 0.0 0.00029 20.6 0.0 1.5 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2779 PF11074.3 ESA06835.1 - 0.057 13.4 0.2 0.071 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) DUF3884 PF13024.1 ESA06835.1 - 0.085 12.2 0.1 0.19 11.1 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3884) DNA_pol_B_2 PF03175.8 ESA06837.1 - 5.7e-08 31.8 2.5 3.1e-07 29.4 1.7 1.9 1 1 0 1 1 1 1 DNA polymerase type B, organellar and viral Endonuclease_7 PF02945.10 ESA06837.1 - 7.1e-07 28.8 1.7 9.1e-07 28.5 0.3 1.8 2 0 0 2 2 2 1 Recombination endonuclease VII zf-C2H2 PF00096.21 ESA06837.1 - 2.3 8.7 7.4 0.61 10.5 2.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA06837.1 - 4 7.9 7.1 2.6 8.5 2.8 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger LRR19-TM PF15176.1 ESA06838.1 - 0.021 14.4 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DDE_3 PF13358.1 ESA06839.1 - 1.4e-11 44.3 0.1 2.2e-11 43.6 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HeH PF12949.2 ESA06839.1 - 0.00026 20.4 0.0 0.0007 19.0 0.0 1.7 1 1 0 1 1 1 1 HeH/LEM domain Hemagglutinin PF00509.13 ESA06839.1 - 0.0096 14.1 0.1 0.012 13.8 0.1 1.0 1 0 0 1 1 1 1 Haemagglutinin HECT PF00632.20 ESA06840.1 - 2.7e-87 292.8 0.2 5.5e-87 291.8 0.0 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) ITAM_Cys-rich PF10538.4 ESA06840.1 - 2.1 7.9 7.8 0.82 9.2 2.4 2.4 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif HMG_box PF00505.14 ESA06841.1 - 0.14 12.4 0.2 0.17 12.1 0.2 1.2 1 0 0 1 1 1 0 HMG (high mobility group) box DUF128 PF01995.11 ESA06842.1 - 5.2 5.9 7.2 25 3.7 0.1 2.9 1 1 2 3 3 3 0 Domain of unknown function DUF128 RRM_6 PF14259.1 ESA06843.1 - 0.0039 17.1 0.0 0.0069 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA06843.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RVT_1 PF00078.22 ESA06844.1 - 0.038 13.3 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) SAM_2 PF07647.12 ESA06845.1 - 0.012 15.4 0.2 0.033 14.0 0.1 1.7 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA06845.1 - 0.11 12.6 0.2 0.3 11.2 0.2 1.7 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Rota_Capsid_VP6 PF00980.12 ESA06846.1 - 0.089 11.4 1.1 0.17 10.4 0.6 1.5 1 1 1 2 2 2 0 Rotavirus major capsid protein VP6 Myb_DNA-bind_3 PF12776.2 ESA06846.1 - 0.85 10.2 5.7 2.6 8.7 0.7 2.9 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain PPR_2 PF13041.1 ESA06847.1 - 1.3e-50 169.1 7.9 4.9e-12 45.6 0.0 8.6 4 1 5 9 9 9 6 PPR repeat family PPR PF01535.15 ESA06847.1 - 1.2e-36 122.1 14.2 1.3e-08 34.2 0.0 9.3 10 1 0 10 10 10 6 PPR repeat PPR_3 PF13812.1 ESA06847.1 - 1.4e-35 118.5 0.1 1.4e-05 24.9 0.0 7.1 7 0 0 7 7 7 6 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA06847.1 - 6e-34 115.2 9.9 1.7e-06 27.3 0.0 7.4 7 1 0 7 7 7 6 PPR repeat Rep_fac_C PF08542.6 ESA06847.1 - 0.017 15.1 0.0 12 6.0 0.0 4.0 3 1 1 4 4 4 0 Replication factor C C-terminal domain TPR_7 PF13176.1 ESA06847.1 - 0.074 12.8 0.0 25 4.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA06847.1 - 0.11 12.4 0.9 13 5.8 0.1 3.6 3 2 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA06848.1 - 5.5e-62 204.8 36.3 8.3e-14 51.7 0.4 7.0 6 1 1 7 7 7 6 Sel1 repeat TPR_17 PF13431.1 ESA06848.1 - 5.2e-07 29.3 15.8 1.7 9.0 0.1 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA06848.1 - 8.6e-07 29.0 11.2 0.71 10.4 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat MIT PF04212.13 ESA06848.1 - 0.00045 20.0 13.1 0.25 11.2 0.1 4.2 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain Flu_M1_C PF08289.6 ESA06848.1 - 0.0042 17.0 0.0 12 6.0 0.0 4.1 2 1 1 4 4 4 1 Influenza Matrix protein (M1) C-terminal domain Surfac_D-trimer PF09006.6 ESA06848.1 - 0.0059 16.3 0.6 25 4.7 0.0 3.7 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation zf-GRF PF06839.7 ESA06848.1 - 0.04 13.8 11.3 0.45 10.4 0.1 4.5 6 0 0 6 6 6 0 GRF zinc finger DUF3674 PF12426.3 ESA06848.1 - 0.094 12.1 12.4 8.4 5.9 0.0 5.7 5 0 0 5 5 5 0 RNA dependent RNA polymerase TPR_12 PF13424.1 ESA06848.1 - 0.46 10.4 19.3 1.1 9.2 0.9 5.4 1 1 5 6 6 6 0 Tetratricopeptide repeat PixA PF12306.3 ESA06848.1 - 1.5 8.6 3.8 5.6 6.7 0.1 2.7 1 1 2 3 3 3 0 Inclusion body protein Arrestin_C PF02752.17 ESA06849.1 - 5.8e-10 39.4 0.1 5.8e-10 39.4 0.1 3.4 4 0 0 4 4 4 1 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.6 ESA06849.1 - 0.00014 21.3 0.1 0.0017 17.7 0.1 2.1 2 0 0 2 2 2 1 SpoOM protein Arrestin_N PF00339.24 ESA06849.1 - 0.00083 19.1 0.5 0.0077 16.0 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Ribosomal_L22e PF01776.12 ESA06850.1 - 1e-33 115.6 0.3 1.2e-33 115.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DNA_pol_A_exo1 PF01612.15 ESA06851.1 - 2.5e-47 160.5 1.9 3.3e-47 160.2 1.3 1.1 1 0 0 1 1 1 1 3'-5' exonuclease Spore_II_R PF09551.5 ESA06853.1 - 0.014 15.4 0.3 0.022 14.7 0.2 1.4 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) Pneumo_phosprot PF02478.11 ESA06853.1 - 0.033 13.7 3.2 0.037 13.5 2.2 1.1 1 0 0 1 1 1 0 Pneumovirus phosphoprotein GvpL_GvpF PF06386.6 ESA06853.1 - 0.051 13.1 0.2 0.059 12.9 0.1 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Myb_DNA-bind_4 PF13837.1 ESA06853.1 - 0.092 12.8 4.7 0.9 9.7 0.3 2.0 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF4446 PF14584.1 ESA06853.1 - 0.16 11.8 0.4 0.25 11.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ribosomal_S25 PF03297.10 ESA06853.1 - 0.22 11.5 2.5 0.31 11.0 1.7 1.3 1 0 0 1 1 1 0 S25 ribosomal protein DUF3279 PF11682.3 ESA06854.1 - 0.01 15.4 10.4 0.21 11.1 1.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3279) BCS1_N PF08740.6 ESA06854.1 - 0.025 14.2 0.7 1 8.9 0.0 3.2 3 1 1 4 4 4 0 BCS1 N terminal DZR PF12773.2 ESA06854.1 - 0.28 11.0 9.9 2.7 7.8 0.4 2.4 2 0 0 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.7 ESA06854.1 - 0.51 10.1 8.5 0.75 9.6 1.3 2.7 2 0 0 2 2 2 0 zinc-ribbons Zn_ribbon_recom PF13408.1 ESA06854.1 - 7.6 6.8 16.6 0.18 12.0 1.6 3.4 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain SAM_2 PF07647.12 ESA06856.1 - 0.012 15.4 0.2 0.072 12.9 0.1 2.1 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.12 ESA06857.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Astacin PF01400.19 ESA06859.1 - 1.1e-18 67.3 0.5 1.3e-18 67.0 0.3 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M91 PF14891.1 ESA06859.1 - 0.055 13.5 0.2 0.066 13.2 0.1 1.2 1 0 0 1 1 1 0 Effector protein Peptidase_M11 PF05548.6 ESA06859.1 - 0.12 11.3 0.2 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 Gametolysin peptidase M11 Cu-oxidase_3 PF07732.10 ESA06861.1 - 9.3e-37 125.3 2.1 1.3e-36 124.8 1.5 1.2 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA06861.1 - 0.0019 17.6 1.1 0.03 13.8 0.8 2.1 1 1 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.17 ESA06861.1 - 0.002 18.0 0.2 0.17 11.7 0.0 2.2 2 0 0 2 2 2 2 Multicopper oxidase IncA PF04156.9 ESA06862.1 - 0.014 14.9 24.4 0.033 13.7 7.1 2.1 1 1 1 2 2 2 0 IncA protein BicD PF09730.4 ESA06862.1 - 0.038 12.3 21.3 0.058 11.7 14.7 1.3 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D ApoC-I PF04691.7 ESA06862.1 - 0.056 13.1 1.0 0.25 11.0 0.7 2.1 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) Snapin_Pallidin PF14712.1 ESA06862.1 - 0.092 13.0 0.9 0.092 13.0 0.7 3.5 1 1 3 4 4 4 0 Snapin/Pallidin Atg14 PF10186.4 ESA06862.1 - 0.25 10.2 21.5 0.56 9.0 8.6 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Prefoldin PF02996.12 ESA06862.1 - 0.26 10.9 13.5 1.3 8.6 1.2 3.3 3 0 0 3 3 3 0 Prefoldin subunit Cep57_MT_bd PF06657.8 ESA06862.1 - 0.27 11.2 15.3 1.5 8.7 0.3 3.4 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ATG16 PF08614.6 ESA06862.1 - 0.31 10.8 25.1 0.19 11.5 6.5 2.6 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF883 PF05957.8 ESA06862.1 - 0.46 10.9 1.9 4.4 7.7 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DivIC PF04977.10 ESA06862.1 - 0.47 9.9 24.7 0.42 10.1 0.5 4.2 2 1 2 4 4 4 0 Septum formation initiator Vir_act_alpha_C PF10400.4 ESA06862.1 - 0.58 10.5 3.0 8.8 6.7 0.3 2.4 2 0 0 2 2 2 0 Virulence activator alpha C-term DUF948 PF06103.6 ESA06862.1 - 0.88 9.4 10.0 2.7 7.9 1.0 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) WXG100 PF06013.7 ESA06862.1 - 0.95 9.5 8.0 14 5.7 0.1 3.6 4 1 0 4 4 3 0 Proteins of 100 residues with WXG DUF3166 PF11365.3 ESA06862.1 - 0.98 9.9 12.8 2.3 8.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3166) Lebercilin PF15619.1 ESA06862.1 - 1.1 8.5 26.4 0.055 12.8 6.9 2.4 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CENP-F_leu_zip PF10473.4 ESA06862.1 - 1.2 8.9 26.5 2.8 7.7 3.0 3.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 ESA06862.1 - 1.5 8.6 26.1 7.4e+03 -3.4 18.1 2.6 1 1 0 1 1 0 0 TPR/MLP1/MLP2-like protein H-kinase_dim PF02895.9 ESA06862.1 - 1.6 9.1 7.7 3.1 8.1 1.5 2.8 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Seryl_tRNA_N PF02403.17 ESA06862.1 - 1.8 8.6 20.5 4.4 7.3 7.9 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Striatin PF08232.7 ESA06862.1 - 2.2 8.5 20.8 1.9 8.8 2.0 2.2 1 1 1 2 2 2 0 Striatin family Transcrip_act PF04949.8 ESA06862.1 - 3.5 7.2 15.7 2.9 7.4 4.3 2.8 2 1 0 2 2 2 0 Transcriptional activator DUF4140 PF13600.1 ESA06862.1 - 4 7.9 10.7 11 6.5 0.2 3.3 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DivIVA PF05103.8 ESA06862.1 - 6.1 6.9 23.6 5.7 7.0 2.5 4.0 1 1 3 4 4 4 0 DivIVA protein Rootletin PF15035.1 ESA06862.1 - 7.9 6.4 24.1 6.2e+02 0.2 16.7 2.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Reo_sigmaC PF04582.7 ESA06862.1 - 8.3 5.4 8.7 23 4.0 4.8 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Reo_sigmaC PF04582.7 ESA06863.1 - 0.016 14.3 6.2 0.02 14.0 4.3 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein WEMBL PF05701.6 ESA06863.1 - 0.056 11.8 21.9 0.063 11.7 15.2 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Cluap1 PF10234.4 ESA06863.1 - 0.073 12.2 21.2 0.066 12.4 11.5 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 APG6 PF04111.7 ESA06863.1 - 0.22 10.5 24.1 0.034 13.1 13.1 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF3584 PF12128.3 ESA06863.1 - 0.24 8.7 20.4 0.41 7.9 14.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.4 ESA06863.1 - 0.28 9.9 21.8 0.35 9.5 15.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 HrpB7 PF09486.5 ESA06863.1 - 0.37 10.7 3.4 2.7 7.8 0.6 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Snapin_Pallidin PF14712.1 ESA06863.1 - 0.37 11.1 21.7 0.14 12.5 4.4 3.1 1 1 2 3 3 3 0 Snapin/Pallidin YycI PF09648.5 ESA06863.1 - 0.55 9.6 18.5 0.63 9.4 12.8 1.1 1 0 0 1 1 1 0 YycH protein TMF_DNA_bd PF12329.3 ESA06863.1 - 0.93 9.3 31.6 3.4 7.5 7.1 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.7 ESA06863.1 - 1.9 8.2 23.5 5.5 6.7 16.3 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein IL6 PF00489.12 ESA06863.1 - 2.5 7.6 9.7 1.3 8.5 1.1 2.1 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family DUF4613 PF15390.1 ESA06863.1 - 3 5.9 15.0 3.6 5.6 10.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2203 PF09969.4 ESA06863.1 - 3.5 7.8 8.8 5.8 7.1 3.3 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ATG16 PF08614.6 ESA06863.1 - 4.3 7.0 25.2 12 5.6 15.6 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) IncA PF04156.9 ESA06863.1 - 4.5 6.8 23.1 1.3e+02 2.0 16.0 2.2 1 1 0 1 1 1 0 IncA protein Exonuc_VII_L PF02601.10 ESA06863.1 - 5 6.2 21.0 5.7 6.0 14.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Macoilin PF09726.4 ESA06863.1 - 6.9 4.8 20.0 9.9 4.2 13.9 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF2935 PF11155.3 ESA06863.1 - 8.6 6.4 12.0 21 5.1 7.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DASH_Dam1 PF08653.5 ESA06863.1 - 9 6.1 7.6 21 4.9 0.1 3.5 3 1 1 4 4 4 0 DASH complex subunit Dam1 DUF1664 PF07889.7 ESA06863.1 - 9.5 6.0 15.1 1.1 9.1 5.8 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Col_cuticle_N PF01484.12 ESA06864.1 - 0.027 14.1 1.0 0.068 12.8 0.7 1.7 1 1 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Rep_3 PF01051.16 ESA06865.1 - 0.003 17.1 3.5 0.003 17.1 2.4 2.0 2 1 0 2 2 2 1 Initiator Replication protein NDUFA12 PF05071.11 ESA06865.1 - 0.0057 17.0 1.1 0.0057 17.0 0.7 1.8 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Pkinase_Tyr PF07714.12 ESA06866.1 - 0.027 13.5 0.2 0.062 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Enoyl_reductase PF12241.3 ESA06866.1 - 0.073 12.0 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region zf-RING_4 PF14570.1 ESA06870.1 - 0.046 13.3 1.1 0.11 12.1 0.8 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF410 PF04190.8 ESA06871.1 - 3.3e-62 210.4 0.2 4e-62 210.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) UCR_14kD PF02271.11 ESA06872.1 - 4.8e-36 122.7 0.1 5.4e-36 122.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit MRP-L51 PF10244.4 ESA06872.1 - 0.065 13.2 0.4 0.15 12.1 0.1 1.7 1 1 0 2 2 2 0 Mitochondrial ribosomal subunit BTB PF00651.26 ESA06874.1 - 3.8e-17 62.2 0.2 6.2e-17 61.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA06874.1 - 9.5e-08 31.8 0.6 2.3e-07 30.5 0.2 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA06874.1 - 0.12 12.5 0.0 0.3 11.3 0.0 1.7 1 1 0 1 1 1 0 BTB/POZ domain Sec23_helical PF04815.10 ESA06879.1 - 1.7e-26 91.6 0.2 3.1e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 ESA06879.1 - 1.3e-09 37.5 0.0 2.2e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat Sec23_BS PF08033.7 ESA06879.1 - 3.7e-08 33.7 0.0 8.5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain DUF4320 PF14208.1 ESA06883.1 - 0.11 12.4 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) NAD_binding_6 PF08030.7 ESA06884.1 - 2.2e-20 73.1 0.0 6.7e-12 45.5 0.0 2.3 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 ESA06884.1 - 3.2e-17 62.7 12.1 3.2e-17 62.7 8.4 2.3 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 ESA06884.1 - 7.2e-14 51.5 0.0 1.6e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 ESA06884.1 - 4.3e-06 27.2 0.0 9.2e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF641 PF04859.7 ESA06887.1 - 0.13 12.0 3.7 0.27 11.0 2.6 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF573 PF04504.9 ESA06887.1 - 0.16 12.2 1.6 0.29 11.4 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF573 Atg14 PF10186.4 ESA06887.1 - 0.32 9.8 5.8 0.47 9.3 4.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FlaC_arch PF05377.6 ESA06887.1 - 1.6 8.7 6.6 0.82 9.6 1.7 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.15 ESA06888.1 - 2.8e-21 75.2 1.1 3.2e-21 75.0 0.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit DASH_Dad3 PF08656.5 ESA06888.1 - 0.0038 16.8 0.8 0.0071 16.0 0.1 1.7 2 0 0 2 2 2 1 DASH complex subunit Dad3 STAT_alpha PF01017.15 ESA06888.1 - 0.0083 15.8 0.5 0.011 15.4 0.4 1.2 1 0 0 1 1 1 1 STAT protein, all-alpha domain Syntaxin_2 PF14523.1 ESA06888.1 - 0.048 13.6 2.3 0.058 13.4 0.4 1.9 2 0 0 2 2 2 0 Syntaxin-like protein DUF2408 PF10303.4 ESA06888.1 - 0.051 13.6 0.9 0.078 13.0 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) SAC3 PF12209.3 ESA06888.1 - 0.059 13.5 1.1 0.44 10.7 0.1 2.1 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain TBPIP PF07106.8 ESA06888.1 - 0.078 12.5 3.0 0.085 12.4 0.3 1.9 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FKBP_N PF01346.13 ESA06888.1 - 0.092 12.7 3.1 0.37 10.8 1.4 1.9 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF148 PF02520.12 ESA06888.1 - 0.13 12.0 3.0 4.2 7.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF148 DASH_Dad2 PF08654.5 ESA06888.1 - 0.17 11.8 1.0 0.48 10.4 0.3 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad2 Peptidase_M75 PF09375.5 ESA06888.1 - 0.18 11.1 1.1 0.36 10.0 0.4 1.6 2 0 0 2 2 2 0 Imelysin Allexi_40kDa PF05549.6 ESA06888.1 - 0.18 11.0 1.8 0.32 10.2 0.4 1.7 1 1 1 2 2 2 0 Allexivirus 40kDa protein Takusan PF04822.8 ESA06888.1 - 0.22 11.3 3.1 0.21 11.3 1.1 1.7 2 0 0 2 2 2 0 Takusan Tho2 PF11262.3 ESA06888.1 - 0.26 10.2 5.3 1.6 7.6 1.0 2.0 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF2316 PF10078.4 ESA06888.1 - 0.37 10.8 1.9 1.4 8.9 0.5 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) zf-rbx1 PF12678.2 ESA06889.1 - 0.13 12.3 10.0 0.29 11.2 2.6 3.8 3 1 1 4 4 4 0 RING-H2 zinc finger Phage_C PF12025.3 ESA06889.1 - 0.47 10.4 2.3 0.85 9.6 0.7 2.0 2 0 0 2 2 2 0 Phage protein C zf-RING_2 PF13639.1 ESA06889.1 - 1 9.2 20.3 0.059 13.2 7.9 3.1 2 2 1 3 3 3 0 Ring finger domain RINGv PF12906.2 ESA06889.1 - 3.4 7.7 7.5 0.12 12.4 0.6 2.1 2 1 0 2 2 2 0 RING-variant domain zf-C3HC4_3 PF13920.1 ESA06889.1 - 3.5 7.3 6.9 27 4.5 4.8 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ABC_tran PF00005.22 ESA06890.1 - 1.8e-37 128.7 0.0 3.8e-37 127.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 ESA06890.1 - 9.1e-19 67.9 2.1 1.3e-18 67.4 1.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.1 ESA06890.1 - 1.9e-08 34.6 2.3 5.7e-06 26.5 0.2 3.1 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.14 ESA06890.1 - 9.6e-08 31.5 1.5 6.1e-07 28.8 0.1 2.4 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 ESA06890.1 - 1.4e-05 25.2 0.1 0.00016 21.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA06890.1 - 1.5e-05 25.0 0.0 4.6e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ESA06890.1 - 3.8e-05 23.5 0.5 0.0011 18.8 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA PF00004.24 ESA06890.1 - 0.00018 21.7 0.1 0.0062 16.7 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA06890.1 - 0.00027 21.7 0.0 0.00066 20.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESA06890.1 - 0.00029 20.8 0.0 0.35 10.8 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.1 ESA06890.1 - 0.00087 19.5 0.1 0.028 14.7 0.0 2.7 3 0 0 3 3 2 1 AAA domain Arch_ATPase PF01637.13 ESA06890.1 - 0.0021 17.8 0.6 0.08 12.6 0.0 2.8 2 1 0 2 2 2 1 Archaeal ATPase AAA_29 PF13555.1 ESA06890.1 - 0.0025 17.3 0.1 0.0064 15.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATP-synt_ab PF00006.20 ESA06890.1 - 0.0047 16.4 0.0 0.015 14.8 0.0 1.8 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF258 PF03193.11 ESA06890.1 - 0.0065 15.6 0.0 0.015 14.4 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 ESA06890.1 - 0.0074 15.7 0.1 0.026 13.9 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA06890.1 - 0.0081 15.8 0.0 0.052 13.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.1 ESA06890.1 - 0.015 15.6 0.2 0.3 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 ESA06890.1 - 0.023 15.1 0.0 0.075 13.5 0.0 2.0 2 0 0 2 2 1 0 Miro-like protein SbcCD_C PF13558.1 ESA06890.1 - 0.027 14.3 0.2 0.26 11.2 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.18 ESA06890.1 - 0.032 14.2 0.1 0.099 12.6 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.15 ESA06890.1 - 0.036 12.7 0.0 0.059 12.0 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Rad17 PF03215.10 ESA06890.1 - 0.038 12.6 0.0 0.067 11.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_10 PF12846.2 ESA06890.1 - 0.053 12.9 0.0 0.23 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain TPR_11 PF13414.1 ESA06890.1 - 0.082 12.5 0.3 0.25 11.0 0.2 1.8 1 0 0 1 1 1 0 TPR repeat MobB PF03205.9 ESA06890.1 - 0.09 12.4 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 ESA06890.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 ESA06890.1 - 0.35 10.4 1.9 1.6 8.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain Rer1 PF03248.8 ESA06891.1 - 1.2e-78 262.7 7.5 1.3e-78 262.5 5.2 1.0 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.4 ESA06891.1 - 0.0025 17.1 0.9 0.0025 17.1 0.7 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2208) HSP70 PF00012.15 ESA06892.1 - 1e-223 743.6 4.7 1.2e-223 743.4 3.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA06892.1 - 8.4e-13 47.6 0.2 1e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA06892.1 - 0.023 13.8 0.1 0.047 12.7 0.1 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase DUF1926 PF09095.6 ESA06894.1 - 0.011 14.9 0.8 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1926) DUF2457 PF10446.4 ESA06895.1 - 0.027 13.1 10.0 0.041 12.6 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Topoisom_I PF01028.15 ESA06895.1 - 0.049 12.7 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core DUF2076 PF09849.4 ESA06895.1 - 0.59 10.1 6.1 5.8 6.8 3.4 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) COPI_C PF06957.6 ESA06895.1 - 2.2 6.7 4.8 3.4 6.1 3.3 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus PBP1_TM PF14812.1 ESA06895.1 - 6.7 7.0 9.5 20 5.5 6.6 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR_4 PF12799.2 ESA06898.1 - 0.044 13.4 0.0 0.08 12.5 0.0 1.5 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESA06898.1 - 0.049 13.8 0.2 0.13 12.5 0.1 1.7 2 0 0 2 2 2 0 Leucine rich repeat Glyco_hydro_47 PF01532.15 ESA06899.1 - 1e-138 462.7 0.0 1.3e-138 462.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF3139 PF11337.3 ESA06899.1 - 1.3 9.3 4.5 0.98 9.7 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Nitr_red_assoc PF09655.5 ESA06900.1 - 3.9 7.7 8.2 22 5.3 0.2 3.8 2 1 2 4 4 4 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) Pkinase_Tyr PF07714.12 ESA06901.1 - 0.00072 18.7 0.0 0.00077 18.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Spb1_C PF07780.7 ESA06903.1 - 0.11 11.9 0.3 0.11 11.9 0.2 1.7 1 1 1 2 2 2 0 Spb1 C-terminal domain Peptidase_M22 PF00814.20 ESA06904.1 - 4.7e-56 190.2 0.1 5.5e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family HTH_13 PF11972.3 ESA06904.1 - 0.038 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 HTH DNA binding domain Pkinase PF00069.20 ESA06908.1 - 6.8e-15 54.9 0.1 1.3e-14 53.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA06908.1 - 2.8e-14 52.8 0.0 4.9e-14 52.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA06908.1 - 0.35 10.1 6.3 1.4 8.2 0.8 2.9 2 1 0 2 2 2 0 RIO1 family Fork_head PF00250.13 ESA06909.1 - 1.7e-39 133.7 0.4 3.8e-39 132.6 0.3 1.6 1 0 0 1 1 1 1 Fork head domain FHA PF00498.21 ESA06909.1 - 1.3e-10 41.2 0.7 2.4e-10 40.3 0.0 1.9 2 0 0 2 2 2 1 FHA domain Wzt_C PF14524.1 ESA06909.1 - 2.3e-05 24.1 0.6 3.9e-05 23.3 0.4 1.3 1 0 0 1 1 1 1 Wzt C-terminal domain SDH_beta PF03315.10 ESA06910.1 - 0.35 10.9 1.3 0.63 10.0 0.9 1.5 1 0 0 1 1 1 0 Serine dehydratase beta chain RRM_5 PF13893.1 ESA06912.1 - 6.5e-06 25.9 1.1 1.2e-05 25.0 0.2 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Collagen PF01391.13 ESA06912.1 - 1.2e-05 24.7 11.9 2e-05 24.0 8.3 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RRM_1 PF00076.17 ESA06912.1 - 6.1e-05 22.5 0.4 0.00014 21.4 0.2 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA06912.1 - 0.0017 18.2 0.0 0.0036 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF4175 PF13779.1 ESA06912.1 - 10 3.7 7.7 13 3.3 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) 7tm_1 PF00001.16 ESA06913.1 - 3.7e-09 36.1 5.6 1.1e-08 34.5 3.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Amastin PF07344.6 ESA06913.1 - 0.23 11.0 7.8 1.7 8.2 1.5 2.3 2 0 0 2 2 2 0 Amastin surface glycoprotein Cation_ATPase_C PF00689.16 ESA06913.1 - 0.4 10.1 10.7 1 8.8 2.1 2.5 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus DUF3671 PF12420.3 ESA06913.1 - 4.1 7.4 13.9 0.54 10.2 4.2 3.1 3 1 1 4 4 4 0 Protein of unknown function GST_C PF00043.20 ESA06914.1 - 1.8e-11 43.8 0.0 2.7e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA06914.1 - 3.9e-08 33.6 0.1 5.2e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA06914.1 - 4.2e-05 23.3 0.0 7.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA06914.1 - 9.3e-05 22.5 0.0 0.00099 19.2 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA06914.1 - 0.00024 21.0 0.0 0.00082 19.3 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA06914.1 - 0.00062 19.8 0.0 0.024 14.7 0.0 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain Abhydrolase_6 PF12697.2 ESA06915.1 - 4.5e-31 108.4 0.0 9.1e-31 107.4 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA06915.1 - 3.6e-26 92.1 0.0 4.7e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA06915.1 - 3.3e-14 52.8 0.0 9.5e-14 51.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESA06915.1 - 2.2e-08 33.8 0.0 6.4e-07 29.1 0.0 2.7 3 0 0 3 3 3 1 Putative lysophospholipase Ndr PF03096.9 ESA06915.1 - 5.4e-07 28.3 0.0 1.1e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 Ndr family Abhydrolase_2 PF02230.11 ESA06915.1 - 0.081 12.3 0.0 8.6 5.7 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase SPRY PF00622.23 ESA06917.1 - 5.2e-09 36.2 0.4 8.8e-09 35.5 0.3 1.3 1 0 0 1 1 1 1 SPRY domain RNA_pol_Rpb2_6 PF00562.23 ESA06918.1 - 1.1e-08 34.3 0.1 1.1e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 PB1 PF00564.19 ESA06919.1 - 2.6e-05 23.8 0.0 3.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 PB1 domain UN_NPL4 PF11543.3 ESA06919.1 - 0.02 15.1 0.1 0.026 14.7 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Inositol_P PF00459.20 ESA06920.1 - 3.7e-55 187.1 0.0 5.9e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family DUF2946 PF11162.3 ESA06920.1 - 0.00086 19.5 0.6 0.0014 18.8 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2946) TruD PF01142.13 ESA06921.1 - 1.4e-70 237.9 0.0 2.9e-69 233.5 0.0 2.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DUF4265 PF14085.1 ESA06922.1 - 0.043 13.5 0.1 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) TPR_8 PF13181.1 ESA06922.1 - 0.16 11.8 2.6 6.4 6.8 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ACCA PF03255.9 ESA06922.1 - 0.55 9.7 8.4 0.18 11.3 0.1 3.2 2 1 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ArsC PF03960.10 ESA06922.1 - 1.6 8.8 7.8 7.5 6.6 0.2 3.2 2 1 2 4 4 4 0 ArsC family DUF4208 PF13907.1 ESA06922.1 - 4.5 7.5 7.2 4.5 7.5 0.7 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF4208) Yae1_N PF09811.4 ESA06923.1 - 1.5e-11 43.6 2.6 2.3e-11 43.0 1.8 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal DUF4399 PF14347.1 ESA06924.1 - 0.013 15.4 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4399) CBM_48 PF02922.13 ESA06924.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) MgsA_C PF12002.3 ESA06925.1 - 7.5e-61 204.6 0.1 2.4e-60 203.0 0.0 2.0 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal RuvB_N PF05496.7 ESA06925.1 - 3e-15 55.8 0.0 7.4e-14 51.3 0.0 2.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 ESA06925.1 - 1.6e-13 51.0 1.2 1.6e-12 47.7 0.0 2.9 1 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESA06925.1 - 4.8e-09 36.1 0.2 1.7e-06 27.9 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA06925.1 - 5.5e-06 26.1 0.0 2.8e-05 23.8 0.0 2.2 1 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 ESA06925.1 - 1.9e-05 24.1 0.0 0.0052 16.2 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.1 ESA06925.1 - 8.9e-05 22.5 0.9 0.042 13.8 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.16 ESA06925.1 - 0.0002 20.5 0.5 0.14 11.3 0.1 3.1 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 ESA06925.1 - 0.00032 20.6 0.3 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESA06925.1 - 0.0009 19.3 6.6 0.0087 16.2 1.9 3.7 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.22 ESA06925.1 - 0.005 17.1 0.3 0.005 17.1 0.2 2.6 3 1 0 3 3 2 1 ABC transporter Guanylate_kin PF00625.16 ESA06925.1 - 0.0053 16.2 0.0 0.019 14.3 0.0 2.0 1 0 0 1 1 1 1 Guanylate kinase TIP49 PF06068.8 ESA06925.1 - 0.0057 15.4 0.5 0.22 10.1 0.0 2.8 2 1 0 2 2 2 1 TIP49 C-terminus AAA_18 PF13238.1 ESA06925.1 - 0.0081 16.4 0.0 0.028 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA06925.1 - 0.014 16.2 0.5 0.04 14.7 0.3 2.0 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESA06925.1 - 0.014 14.5 0.1 0.05 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 ESA06925.1 - 0.019 14.5 0.1 0.092 12.3 0.0 2.3 3 0 0 3 3 1 0 AAA domain AAA_10 PF12846.2 ESA06925.1 - 0.021 14.2 4.0 0.61 9.4 0.2 2.8 3 1 0 3 3 3 0 AAA-like domain Peptidase_C10 PF01640.12 ESA06925.1 - 0.024 14.4 0.0 0.061 13.0 0.0 1.8 1 0 0 1 1 1 0 Peptidase C10 family NB-ARC PF00931.17 ESA06925.1 - 0.033 13.0 0.3 0.19 10.5 0.1 2.1 1 1 1 2 2 2 0 NB-ARC domain AAA_33 PF13671.1 ESA06925.1 - 0.038 13.8 0.0 0.066 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESA06925.1 - 0.047 13.3 1.4 4.4 6.9 0.0 2.8 1 1 1 2 2 2 0 Archaeal ATPase IstB_IS21 PF01695.12 ESA06925.1 - 0.065 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 ESA06925.1 - 0.081 13.0 0.0 0.081 13.0 0.0 2.6 3 0 0 3 3 2 0 RNA helicase PRP21_like_P PF12230.3 ESA06925.1 - 0.72 9.3 10.7 0.24 10.8 2.4 2.6 1 1 1 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Got1 PF04178.7 ESA06926.1 - 7.6e-20 71.1 14.7 8.5e-20 71.0 10.2 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF3185 PF11381.3 ESA06926.1 - 3.2 7.5 10.4 4.7 7.0 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Chitin_bind_1 PF00187.14 ESA06927.1 - 1.3e-09 37.8 24.2 1.3e-09 37.8 16.8 2.5 2 1 1 3 3 3 1 Chitin recognition protein BDV_P24 PF06595.6 ESA06931.1 - 0.018 14.8 0.4 0.66 9.7 0.0 2.1 2 0 0 2 2 2 0 Borna disease virus P24 protein SAC3 PF12209.3 ESA06932.1 - 0.024 14.7 0.2 0.034 14.2 0.1 1.3 1 1 0 1 1 1 0 Leucine permease transcriptional regulator helical domain YARHG PF13308.1 ESA06933.1 - 0.037 13.5 0.1 0.061 12.8 0.1 1.4 1 1 0 1 1 1 0 YARHG domain PG_binding_4 PF12229.3 ESA06934.1 - 0.046 13.9 0.2 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DUF3684 PF12449.3 ESA06935.1 - 1.6e-162 542.6 1.0 2.2e-158 528.9 0.2 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA06935.1 - 0.00018 21.1 0.0 0.00048 19.7 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA06935.1 - 0.012 15.2 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BCS1_N PF08740.6 ESA06936.1 - 0.0001 22.0 0.1 1.2 8.7 0.0 3.8 4 0 0 4 4 4 2 BCS1 N terminal CaMKII_AD PF08332.5 ESA06936.1 - 0.0053 16.6 0.7 3 7.7 0.0 4.6 5 0 0 5 5 5 1 Calcium/calmodulin dependent protein kinase II Association CUT PF02376.10 ESA06936.1 - 0.053 13.3 0.0 7.2 6.4 0.0 3.1 2 0 0 2 2 2 0 CUT domain zinc_ribbon_2 PF13240.1 ESA06936.1 - 0.1 12.0 23.8 2 8.0 0.2 5.5 5 0 0 5 5 5 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESA06936.1 - 0.91 8.8 23.8 3 7.1 0.0 5.2 5 0 0 5 5 5 0 zinc-ribbon domain AAA PF00004.24 ESA06938.1 - 0.081 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RRM_1 PF00076.17 ESA06940.1 - 6.6e-08 32.0 0.3 1.2e-07 31.2 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA06940.1 - 1.6e-06 28.0 0.1 2.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA06940.1 - 0.0033 17.2 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA06940.1 - 0.0045 16.7 0.0 0.0076 15.9 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif PPR_1 PF12854.2 ESA06941.1 - 0.018 14.5 0.3 0.032 13.7 0.2 1.5 1 0 0 1 1 1 0 PPR repeat PPR_2 PF13041.1 ESA06941.1 - 0.13 12.2 0.7 0.26 11.2 0.5 1.4 1 0 0 1 1 1 0 PPR repeat family BCS1_N PF08740.6 ESA06943.1 - 3.1e-05 23.6 0.0 0.012 15.2 0.0 2.8 3 0 0 3 3 3 2 BCS1 N terminal THF_DHG_CYH PF00763.18 ESA06943.1 - 0.0082 16.1 7.0 1.5 8.8 0.1 4.6 3 1 0 4 4 4 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CUT PF02376.10 ESA06943.1 - 0.013 15.2 0.0 0.12 12.1 0.0 2.4 2 0 0 2 2 2 0 CUT domain DUF4413 PF14372.1 ESA06943.1 - 0.014 15.3 4.9 0.32 11.0 0.2 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) zf-dskA_traR PF01258.12 ESA06943.1 - 0.065 12.9 13.6 3.5 7.4 1.0 4.1 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger bPH_4 PF06713.6 ESA06943.1 - 0.14 12.0 6.1 6.1 6.7 0.0 4.0 4 0 0 4 4 4 0 Bacterial PH domain Soyouz_module PF14313.1 ESA06943.1 - 0.42 10.1 4.5 2.6 7.6 0.0 4.1 4 0 0 4 4 4 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Pkinase PF00069.20 ESA06945.1 - 0.002 17.3 0.3 0.0029 16.8 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Med6 PF04934.9 ESA06945.1 - 0.076 12.5 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 MED6 mediator sub complex component Peptidase_S10 PF00450.17 ESA06946.1 - 4.5e-98 329.1 0.8 5.1e-98 328.9 0.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase dDENN PF03455.14 ESA06946.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 dDENN domain Pkinase_Tyr PF07714.12 ESA06949.1 - 3e-17 62.5 0.0 4.7e-16 58.6 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase BCS1_N PF08740.6 ESA06949.1 - 0.00012 21.7 0.1 3.3 7.2 0.0 5.2 5 0 0 5 5 5 2 BCS1 N terminal DUF3299 PF11736.3 ESA06949.1 - 0.0055 16.6 13.2 14 5.5 0.0 6.6 8 0 0 8 8 8 3 Protein of unknown function (DUF3299) APH PF01636.18 ESA06949.1 - 0.25 11.0 0.1 0.37 10.4 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA06950.1 - 5.2e-39 133.8 0.0 1.2e-38 132.7 0.0 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA06950.1 - 2.7e-36 125.0 0.1 2.7e-36 125.0 0.0 1.7 3 0 0 3 3 3 1 Protein kinase domain YchF-GTPase_C PF06071.8 ESA06950.1 - 0.013 15.2 0.0 0.036 13.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF933) Ku_PK_bind PF08785.6 ESA06951.1 - 6.3 6.7 9.8 8.2 6.3 0.1 3.2 2 2 0 2 2 2 0 Ku C terminal domain like HSCB_C PF07743.8 ESA06952.1 - 1.8e-16 60.3 4.1 1.8e-16 60.3 2.9 2.1 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 ESA06952.1 - 4.5e-11 42.3 0.1 1e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain D5_N PF08706.6 ESA06952.1 - 0.0034 17.4 1.0 0.0057 16.7 0.7 1.6 1 1 0 1 1 1 1 D5 N terminal like CemA PF03040.9 ESA06952.1 - 0.39 10.2 4.8 0.34 10.4 2.3 1.6 2 0 0 2 2 2 0 CemA family zf-C3HC4_2 PF13923.1 ESA06953.1 - 4.1e-05 23.5 5.9 7.1e-05 22.7 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA06953.1 - 0.066 13.0 6.0 0.1 12.4 4.2 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.20 ESA06953.1 - 0.095 12.3 6.9 0.19 11.3 4.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA06953.1 - 0.19 11.4 7.9 0.29 10.8 5.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 ESA06953.1 - 0.21 11.4 3.2 0.36 10.6 2.2 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Neur_chan_memb PF02932.11 ESA06953.1 - 9.5 6.0 6.0 12 5.6 4.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spo0A_C PF08769.6 ESA06954.1 - 0.097 12.5 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal MogR_DNAbind PF12181.3 ESA06956.1 - 0.044 13.5 0.0 0.044 13.5 0.0 1.0 1 0 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) LAMTOR PF15454.1 ESA06958.1 - 0.075 13.3 0.7 0.19 12.0 0.2 2.0 1 1 1 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF4098 PF13345.1 ESA06959.1 - 0.025 14.5 4.0 0.29 11.0 2.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4098) Pentapeptide_2 PF01469.13 ESA06959.1 - 1.4 8.6 8.9 3.7 7.2 0.7 2.7 2 1 0 2 2 2 0 Pentapeptide repeats (8 copies) MOSC PF03473.12 ESA06965.1 - 0.15 11.4 0.2 5.2 6.5 0.0 2.6 1 1 1 2 2 2 0 MOSC domain Surp PF01805.15 ESA06967.1 - 2.7e-19 68.5 0.1 8.3e-19 67.0 0.1 1.9 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.17 ESA06967.1 - 4e-16 58.4 0.0 8.9e-16 57.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA06967.1 - 7.7e-12 45.0 0.0 1.7e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA06967.1 - 6.1e-07 29.1 0.0 1.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.3 ESA06967.1 - 0.00017 21.2 0.0 0.00041 20.0 0.0 1.7 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTD_bind PF04818.8 ESA06967.1 - 0.0019 18.4 0.8 0.0064 16.7 0.1 2.4 2 1 0 2 2 2 1 RNA polymerase II-binding domain. DUF4187 PF13821.1 ESA06968.1 - 1.1e-18 66.5 7.2 1.1e-18 66.5 5.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.18 ESA06968.1 - 9.5e-10 38.1 2.1 1.7e-09 37.2 1.4 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA06968.1 - 2.1e-06 27.5 0.4 7.5e-06 25.7 0.3 2.1 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF2572 PF10833.3 ESA06968.1 - 0.052 12.9 0.3 0.078 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) 3HCDH_N PF02737.13 ESA06970.1 - 3.6e-38 130.9 0.5 4.7e-38 130.6 0.4 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 ESA06970.1 - 4.3e-05 23.4 0.1 9.3e-05 22.3 0.1 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 ESA06970.1 - 0.0002 21.1 0.1 0.00028 20.6 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 ESA06970.1 - 0.0014 18.9 0.5 0.0064 16.9 0.1 2.2 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 ESA06970.1 - 0.018 15.1 0.1 0.026 14.6 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CoA_binding PF02629.14 ESA06970.1 - 0.063 13.7 0.1 0.22 12.0 0.1 2.0 1 1 0 1 1 1 0 CoA binding domain DUF1328 PF07043.8 ESA06970.1 - 2.7 8.0 4.7 19 5.3 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1328) Abhydrolase_6 PF12697.2 ESA06971.1 - 3.7e-15 56.4 0.0 4e-15 56.3 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA06971.1 - 1.4e-09 37.8 0.0 1.6e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESA06971.1 - 3.7e-06 26.7 0.0 4.3e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 ESA06971.1 - 1e-05 25.2 0.0 1.3e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.15 ESA06971.1 - 0.003 17.8 0.0 0.0032 17.7 0.0 1.0 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.8 ESA06971.1 - 0.0062 16.1 0.1 0.0068 16.0 0.0 1.0 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 ESA06971.1 - 0.0084 15.4 0.1 0.0099 15.1 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF3242 PF11586.3 ESA06971.1 - 0.056 12.9 0.0 0.07 12.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3242) FA_hydroxylase PF04116.8 ESA06972.1 - 1.1e-16 61.1 7.7 1.5e-16 60.7 5.3 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Corona_3 PF04694.7 ESA06973.1 - 0.11 12.3 0.9 0.18 11.7 0.6 1.3 1 0 0 1 1 1 0 Coronavirus ORF3 protein SAM_2 PF07647.12 ESA06976.1 - 0.0017 18.1 0.1 0.0028 17.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA06976.1 - 0.0057 16.8 0.0 0.0076 16.3 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DDE_3 PF13358.1 ESA06977.1 - 1.8e-09 37.4 0.0 2.2e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 ESA06977.1 - 0.014 14.1 0.0 0.016 13.9 0.0 1.1 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF4248 PF14053.1 ESA06977.1 - 0.021 14.4 0.0 0.033 13.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4248) rve PF00665.21 ESA06977.1 - 0.048 13.7 0.0 0.07 13.2 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Zw10 PF06248.8 ESA06978.1 - 5.8e-49 166.7 8.5 8.7e-49 166.1 5.9 1.3 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.3 ESA06978.1 - 5.3e-16 58.6 5.6 5.3e-16 58.6 3.9 2.4 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal GATase PF00117.23 ESA06979.1 - 3.1e-37 127.8 0.0 4.3e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESA06979.1 - 6.4e-08 32.3 0.0 1.8e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 Self-incomp_S1 PF05938.6 ESA06980.1 - 9.1e-14 51.5 0.2 1.1e-13 51.2 0.1 1.1 1 0 0 1 1 1 1 Plant self-incompatibility protein S1 Pex14_N PF04695.8 ESA06981.1 - 0.076 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HMG_box PF00505.14 ESA06982.1 - 0.00013 22.1 1.5 0.00025 21.2 0.9 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA06982.1 - 0.0035 17.6 0.2 0.0064 16.8 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain DASH_Dad1 PF08649.5 ESA06983.1 - 0.058 13.0 1.3 0.085 12.5 0.1 1.9 2 0 0 2 2 2 0 DASH complex subunit Dad1 MU117 PF15474.1 ESA06983.1 - 0.16 12.4 1.3 0.39 11.2 0.9 1.6 1 0 0 1 1 1 0 Meiotically up-regulated gene family FliJ PF02050.11 ESA06983.1 - 0.17 11.9 3.9 0.09 12.8 0.8 1.8 2 0 0 2 2 2 0 Flagellar FliJ protein DUF1664 PF07889.7 ESA06983.1 - 0.3 10.8 5.0 0.27 11.0 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3734 PF12536.3 ESA06983.1 - 0.31 11.1 2.2 0.97 9.5 0.8 2.0 2 0 0 2 2 2 0 Patatin phospholipase DUF641 PF04859.7 ESA06983.1 - 0.41 10.3 3.0 0.75 9.5 0.7 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) GIIM PF08388.6 ESA06983.1 - 0.63 9.8 3.4 0.81 9.5 0.1 2.2 2 0 0 2 2 2 0 Group II intron, maturase-specific domain DUF1759 PF03564.10 ESA06983.1 - 0.66 9.7 6.4 0.66 9.7 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1759) DUF948 PF06103.6 ESA06983.1 - 1.2 9.0 3.8 1.1 9.2 1.3 1.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.6 ESA06983.1 - 3.9 7.2 13.0 0.17 11.7 4.1 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Myb_DNA-bind_4 PF13837.1 ESA06983.1 - 7.3 6.7 7.8 1.9 8.6 0.8 3.0 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain SNase PF00565.12 ESA06984.1 - 2.4e-09 37.4 0.4 3e-09 37.0 0.3 1.1 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Mog1 PF04603.7 ESA06984.1 - 0.063 13.2 0.2 5.9 6.8 0.1 2.1 2 0 0 2 2 2 0 Ran-interacting Mog1 protein RRF PF01765.14 ESA06984.1 - 0.087 12.2 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Ribosome recycling factor bPH_4 PF06713.6 ESA06985.1 - 0.016 15.0 1.0 0.32 10.9 0.1 2.2 2 0 0 2 2 2 0 Bacterial PH domain Chlorophyllase2 PF12740.2 ESA06985.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Arrestin_N PF00339.24 ESA06986.1 - 6.9e-10 38.9 0.0 1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA06986.1 - 0.0011 19.0 0.0 0.58 10.2 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 ESA06986.1 - 0.0017 17.8 0.0 0.0028 17.1 0.0 1.4 1 1 0 1 1 1 1 Arrestin_N terminal like Synaptobrevin PF00957.16 ESA06987.1 - 0.093 12.3 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Synaptobrevin HTH_23 PF13384.1 ESA06988.1 - 5.8e-06 25.7 0.1 3e-05 23.5 0.0 2.2 3 1 0 3 3 3 1 Homeodomain-like domain HTH_29 PF13551.1 ESA06988.1 - 0.00082 19.5 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix PAX PF00292.13 ESA06988.1 - 0.0022 17.6 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 ESA06988.1 - 0.0039 16.8 0.0 0.005 16.5 0.0 1.3 1 1 0 1 1 1 1 Transposase Terminase_5 PF06056.7 ESA06988.1 - 0.062 12.8 0.1 0.16 11.5 0.0 1.7 1 1 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DivIVA PF05103.8 ESA06988.1 - 0.094 12.7 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 DivIVA protein Chromo PF00385.19 ESA06993.1 - 0.0001 21.9 0.4 0.0002 20.9 0.3 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain GNAT_acetyltran PF12746.2 ESA06993.1 - 0.017 13.9 0.1 0.017 13.9 0.1 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase RraB PF06877.6 ESA06993.1 - 0.13 12.9 0.1 0.15 12.7 0.1 1.1 1 0 0 1 1 1 0 Regulator of ribonuclease activity B Podoplanin PF05808.6 ESA06994.1 - 0.95 9.0 6.4 1.8 8.0 4.5 1.4 1 0 0 1 1 1 0 Podoplanin U3_assoc_6 PF08640.6 ESA06995.1 - 0.011 15.4 0.6 0.017 14.8 0.4 1.4 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 PB1 PF00564.19 ESA06998.1 - 0.0061 16.1 0.1 0.015 14.9 0.1 1.7 1 0 0 1 1 1 1 PB1 domain HSDR_N PF04313.9 ESA06998.1 - 0.032 13.9 2.6 0.05 13.3 1.8 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Herpes_LMP1 PF05297.6 ESA06999.1 - 0.4 9.5 6.9 0.53 9.1 4.8 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) NOSIC PF08060.8 ESA07000.1 - 0.025 14.3 2.7 0.15 11.9 0.1 2.9 3 0 0 3 3 3 0 NOSIC (NUC001) domain DUF3452 PF11934.3 ESA07000.1 - 0.36 10.1 2.5 0.88 8.8 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3452) BTB PF00651.26 ESA07001.1 - 6.9e-19 67.8 0.3 1.5e-18 66.7 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA07001.1 - 0.021 14.9 3.0 0.75 9.9 0.0 3.2 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain Synaptobrevin PF00957.16 ESA07002.1 - 5.9e-32 109.1 1.0 8.9e-32 108.5 0.7 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 ESA07002.1 - 7.2e-30 102.3 0.1 1.1e-29 101.8 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Rad60-SLD_2 PF13881.1 ESA07003.1 - 2.4e-20 72.4 1.2 2.7e-20 72.3 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESA07003.1 - 2.9e-10 39.3 0.0 2.5e-09 36.4 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 ESA07003.1 - 0.026 14.6 0.2 0.081 13.1 0.0 1.8 1 1 0 2 2 2 0 DUF2407 ubiquitin-like domain Apt1 PF10351.4 ESA07003.1 - 3.4 6.3 8.2 4.3 6.0 5.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain eIF3_subunit PF08597.5 ESA07004.1 - 1.8e-42 145.6 21.8 2.2e-42 145.2 15.1 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Milton PF12448.3 ESA07004.1 - 0.15 12.2 1.1 0.25 11.5 0.6 1.4 1 1 0 1 1 1 0 Kinesin associated protein SR-25 PF10500.4 ESA07004.1 - 0.41 10.0 9.8 0.81 9.1 6.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FNIP_N PF14636.1 ESA07004.1 - 5.1 7.5 7.6 1.1 9.6 2.1 2.0 2 1 0 2 2 2 0 Folliculin-interacting protein N-terminus V_ATPase_I PF01496.14 ESA07004.1 - 5.6 4.6 6.6 6.1 4.5 4.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YhdB PF14148.1 ESA07008.1 - 0.007 16.0 0.1 0.0076 15.9 0.0 1.1 1 0 0 1 1 1 1 YhdB-like protein DUF2344 PF10105.4 ESA07008.1 - 0.048 13.1 0.0 0.049 13.1 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Anoctamin PF04547.7 ESA07009.1 - 3.5e-102 342.3 6.4 1.6e-82 277.5 1.4 2.0 1 1 1 2 2 2 2 Calcium-activated chloride channel DUF4077 PF13295.1 ESA07009.1 - 0.24 11.1 5.4 0.28 10.9 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4077) TLD PF07534.11 ESA07010.1 - 9.8e-13 48.2 0.4 4.2e-11 43.0 0.1 2.2 2 0 0 2 2 2 2 TLD BACK PF07707.10 ESA07010.1 - 8.3e-09 35.2 0.3 1.2e-07 31.4 0.1 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch PLA2_B PF01735.13 ESA07012.1 - 7.8e-31 106.7 0.0 1.6e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Pox_E8 PF03394.8 ESA07012.1 - 0.09 12.1 0.1 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Poxvirus E8 protein Dynamin_N PF00350.18 ESA07013.1 - 4.5e-19 68.8 0.0 1.7e-09 37.7 0.0 2.3 2 0 0 2 2 2 2 Dynamin family Miro PF08477.8 ESA07013.1 - 0.00044 20.7 0.0 0.0014 19.0 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 ESA07013.1 - 0.013 15.4 0.0 0.041 13.8 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase SRPRB PF09439.5 ESA07013.1 - 0.032 13.4 0.0 0.38 9.9 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit FtsK_SpoIIIE PF01580.13 ESA07013.1 - 0.088 12.2 0.0 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family GTP_EFTU PF00009.22 ESA07013.1 - 0.1 11.9 0.0 8.6 5.7 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PTR2 PF00854.16 ESA07014.1 - 0.064 12.0 0.1 0.064 12.0 0.1 1.5 2 0 0 2 2 2 0 POT family DUF4120 PF13496.1 ESA07014.1 - 0.094 12.7 1.1 0.17 11.9 0.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4120) Lys PF00062.15 ESA07014.1 - 0.32 11.0 4.0 0.58 10.1 2.8 1.4 1 0 0 1 1 1 0 C-type lysozyme/alpha-lactalbumin family Polyketide_cyc2 PF10604.4 ESA07016.1 - 0.00019 21.6 0.0 0.00022 21.4 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport TLD PF07534.11 ESA07018.1 - 1.2e-12 48.0 3.2 1.2e-12 48.0 2.3 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA07018.1 - 1.1e-07 31.6 0.1 2.9e-07 30.2 0.1 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Aha1_N PF09229.6 ESA07019.1 - 4.8e-37 126.8 0.6 7.4e-37 126.2 0.4 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 ESA07019.1 - 0.016 15.3 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Activator of Hsp90 ATPase homolog 1-like protein FTZ PF03867.9 ESA07019.1 - 0.18 10.9 3.5 0.24 10.5 2.4 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Pkinase PF00069.20 ESA07021.1 - 2e-17 63.2 0.0 2.2e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07021.1 - 7.8e-16 57.9 0.0 8.5e-16 57.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase cwf21 PF08312.7 ESA07022.1 - 0.69 9.8 3.8 0.26 11.1 0.2 2.1 2 0 0 2 2 2 0 cwf21 domain Myb_DNA-binding PF00249.26 ESA07024.1 - 2.4e-05 24.2 0.1 4.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain FERM_C PF09380.5 ESA07024.1 - 0.046 13.9 0.1 0.076 13.2 0.1 1.4 1 0 0 1 1 1 0 FERM C-terminal PH-like domain Myb_DNA-bind_6 PF13921.1 ESA07024.1 - 0.065 13.3 2.6 0.29 11.2 0.1 2.8 3 0 0 3 3 3 0 Myb-like DNA-binding domain IBN_N PF03810.14 ESA07025.1 - 1.5e-13 50.4 1.8 9.6e-10 38.2 0.0 5.3 6 0 0 6 6 6 2 Importin-beta N-terminal domain Xpo1 PF08389.7 ESA07025.1 - 5.4e-06 26.3 2.5 0.0023 17.8 0.1 4.1 4 1 0 4 4 4 2 Exportin 1-like protein Cse1 PF08506.5 ESA07025.1 - 2.1e-05 23.2 1.1 2.1e-05 23.2 0.8 2.9 2 1 1 3 3 3 1 Cse1 HEAT PF02985.17 ESA07025.1 - 8e-05 22.4 3.0 1.9 8.7 0.0 6.9 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.1 ESA07025.1 - 0.00023 21.3 4.7 0.6 10.4 0.0 6.0 6 1 0 7 7 7 1 HEAT repeats Cnd1 PF12717.2 ESA07025.1 - 0.033 14.0 1.0 1.1 9.0 0.0 3.7 5 1 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 DUF3295 PF11702.3 ESA07025.1 - 0.94 8.3 4.7 1.6 7.6 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Transaldolase PF00923.14 ESA07026.1 - 2.5e-106 355.0 0.3 2.8e-106 354.8 0.2 1.0 1 0 0 1 1 1 1 Transaldolase Ino80_Iec3 PF14612.1 ESA07027.1 - 9.2e-09 35.6 2.8 9.7e-09 35.6 2.0 1.1 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling GAS PF13851.1 ESA07027.1 - 0.002 17.3 2.5 0.0023 17.1 1.7 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.16 ESA07027.1 - 0.0067 16.3 2.4 0.0099 15.8 1.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor DUF972 PF06156.8 ESA07027.1 - 0.0085 16.4 1.2 0.0097 16.2 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF972) DivIVA PF05103.8 ESA07027.1 - 0.012 15.6 0.8 0.015 15.3 0.5 1.2 1 0 0 1 1 1 0 DivIVA protein DUF4600 PF15372.1 ESA07027.1 - 0.025 14.7 0.9 0.028 14.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) Glu_syn_central PF04898.9 ESA07027.1 - 0.074 12.2 0.2 0.083 12.1 0.1 1.1 1 0 0 1 1 1 0 Glutamate synthase central domain DUF2205 PF10224.4 ESA07027.1 - 0.082 12.4 1.4 0.1 12.1 1.0 1.2 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) DUF342 PF03961.8 ESA07027.1 - 0.12 10.8 0.6 0.12 10.7 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Kinesin-related PF06548.6 ESA07027.1 - 0.13 10.7 2.5 0.14 10.6 1.7 1.0 1 0 0 1 1 1 0 Kinesin-related HALZ PF02183.13 ESA07027.1 - 0.17 11.6 10.1 1.8 8.3 3.0 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper IncA PF04156.9 ESA07027.1 - 0.24 10.9 0.8 0.28 10.7 0.6 1.1 1 0 0 1 1 1 0 IncA protein Chibby PF14645.1 ESA07027.1 - 0.27 11.1 3.2 0.41 10.5 2.2 1.5 1 1 0 1 1 1 0 Chibby family RTP801_C PF07809.6 ESA07028.1 - 0.046 13.3 0.2 0.19 11.3 0.0 2.0 1 1 0 2 2 2 0 RTP801 C-terminal region DUF1828 PF08861.5 ESA07028.1 - 0.79 9.4 5.2 2.7 7.6 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF1828 Basic PF01586.11 ESA07029.1 - 0.24 12.1 2.3 0.28 11.9 1.6 1.1 1 0 0 1 1 1 0 Myogenic Basic domain UDG PF03167.14 ESA07030.1 - 7.8e-13 48.1 0.0 1e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF3116 PF11313.3 ESA07030.1 - 0.11 12.0 0.4 0.28 10.8 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3116) DDE_1 PF03184.14 ESA07033.1 - 6.3e-21 74.5 5.3 8.5e-11 41.4 0.4 3.8 1 1 2 3 3 3 3 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA07033.1 - 1.2e-15 57.0 0.0 2.3e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA07033.1 - 0.019 14.7 0.4 0.045 13.4 0.3 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease RNA_pol_Rpb1_1 PF04997.7 ESA07033.1 - 0.12 11.6 0.1 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 DUF4206 PF13901.1 ESA07033.1 - 0.13 11.8 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) DDE_1 PF03184.14 ESA07035.1 - 8.4e-25 87.1 1.3 1.8e-23 82.8 0.2 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA07035.1 - 2e-12 46.6 0.1 3.6e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF3882 PF07066.6 ESA07035.1 - 0.067 13.0 0.2 0.22 11.3 0.0 1.8 1 1 1 2 2 2 0 Lactococcus phage M3 protein Pkinase_Tyr PF07714.12 ESA07037.1 - 0.0087 15.1 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ubiquitin PF00240.18 ESA07038.1 - 4.6e-19 67.5 0.0 9.8e-19 66.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA07038.1 - 3e-13 49.2 0.0 4.9e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ESA07038.1 - 0.01 15.9 0.0 0.019 15.1 0.0 1.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.1 ESA07038.1 - 0.045 14.0 0.0 0.13 12.5 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain DUF3990 PF13151.1 ESA07038.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) PARP PF00644.15 ESA07038.1 - 0.076 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain Rad60-SLD_2 PF13881.1 ESA07038.1 - 0.082 12.7 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like WD40 PF00400.27 ESA07039.1 - 1e-26 91.7 0.4 9.8e-09 34.7 0.0 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESA07039.1 - 0.00066 18.5 1.4 0.45 9.2 0.0 2.5 1 1 2 3 3 3 2 Nup133 N terminal like Nup160 PF11715.3 ESA07039.1 - 0.00098 17.3 0.1 0.22 9.6 0.0 2.4 2 1 1 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 ESA07039.1 - 0.15 11.8 0.1 1.9 8.2 0.0 2.5 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DPBB_1 PF03330.13 ESA07040.1 - 6.1e-09 35.7 0.0 1.2e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 ESA07040.1 - 0.015 14.9 0.2 0.018 14.7 0.2 1.2 1 0 0 1 1 1 0 Barwin family Cas_CXXC_CXXC PF09706.5 ESA07040.1 - 0.46 10.6 2.3 7.5 6.8 0.0 2.7 2 1 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) Pkinase_Tyr PF07714.12 ESA07041.1 - 0.00041 19.5 0.1 0.00048 19.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3414 PF11894.3 ESA07041.1 - 0.049 10.5 0.0 0.053 10.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3414) SUV3_C PF12513.3 ESA07041.1 - 0.12 11.8 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal CCDC66 PF15236.1 ESA07041.1 - 0.15 11.6 0.3 0.2 11.2 0.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Ground-like PF04155.13 ESA07042.1 - 0.12 12.7 0.5 0.12 12.7 0.3 4.9 3 1 1 4 4 4 0 Ground-like domain Cation_efflux PF01545.16 ESA07042.1 - 0.82 8.6 7.8 3.6 6.5 5.4 2.0 1 1 0 1 1 1 0 Cation efflux family DUF4551 PF15087.1 ESA07042.1 - 2.8 6.2 10.8 3.8 5.7 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ribosomal_L18p PF00861.17 ESA07043.1 - 3.3e-41 140.2 0.0 3.3e-41 140.2 0.0 1.9 3 0 0 3 3 3 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 ESA07043.1 - 5.5e-33 113.3 5.7 5.5e-33 113.3 4.0 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Abhydrolase_1 PF00561.15 ESA07045.1 - 2.1e-20 73.2 0.0 1.9e-18 66.8 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESA07045.1 - 2.2e-08 34.2 0.0 7.5e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 ESA07045.1 - 0.00048 19.6 0.0 0.00088 18.7 0.0 1.4 1 0 0 1 1 1 1 Putative esterase RRM_1 PF00076.17 ESA07046.1 - 1.7e-16 59.6 0.8 2.1e-16 59.2 0.1 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA07046.1 - 2.1e-10 40.4 0.0 3.3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA07046.1 - 3.8e-07 29.8 0.0 6.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA07046.1 - 0.0097 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Sel1 PF08238.7 ESA07047.1 - 9.6e-34 115.0 9.2 5e-08 33.3 0.1 4.8 5 0 0 5 5 5 4 Sel1 repeat Pkinase_Tyr PF07714.12 ESA07047.1 - 4.6e-05 22.6 0.0 8e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07047.1 - 0.0011 18.2 0.0 0.0025 17.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Xpo1 PF08389.7 ESA07047.1 - 0.032 14.1 0.4 0.054 13.4 0.3 1.3 1 0 0 1 1 1 0 Exportin 1-like protein DUF2990 PF11693.3 ESA07047.1 - 0.086 12.7 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) LBP_BPI_CETP_C PF02886.12 ESA07048.1 - 0.15 11.2 4.9 0.17 11.0 3.4 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain BRAP2 PF07576.7 ESA07048.1 - 2.6 7.6 6.2 6.4 6.3 3.8 2.0 1 1 0 1 1 1 0 BRCA1-associated protein 2 Streptin-Immun PF11083.3 ESA07050.1 - 0.045 13.7 0.1 0.06 13.3 0.1 1.2 1 0 0 1 1 1 0 Lantibiotic streptin immunity protein Pkinase_Tyr PF07714.12 ESA07052.1 - 1.9e-05 23.8 0.0 2.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FadA PF09403.5 ESA07052.1 - 0.65 10.0 5.6 1 9.3 3.9 1.3 1 0 0 1 1 1 0 Adhesion protein FadA DUF2962 PF11176.3 ESA07053.1 - 0.015 14.9 0.7 0.018 14.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2962) Mago_nashi PF02792.9 ESA07053.1 - 0.11 12.1 1.0 0.13 11.9 0.7 1.1 1 0 0 1 1 1 0 Mago nashi protein Methyltransf_23 PF13489.1 ESA07054.1 - 1.2e-15 57.6 0.0 1.9e-15 56.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA07054.1 - 4.7e-14 52.6 0.0 9e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA07054.1 - 3.4e-11 43.4 0.0 1.2e-10 41.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA07054.1 - 5.8e-11 42.2 0.0 4.4e-10 39.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA07054.1 - 1.1e-08 35.4 0.0 3e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA07054.1 - 1.3e-08 34.2 0.0 3.9e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA07054.1 - 4.4e-08 33.6 0.0 3.3e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA07054.1 - 8.6e-05 21.6 0.0 0.00029 19.9 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase MetW PF07021.7 ESA07054.1 - 0.00011 21.5 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA07054.1 - 0.0013 18.7 0.0 0.0039 17.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA07054.1 - 0.0036 17.3 0.1 0.01 15.8 0.0 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ESA07054.1 - 0.036 13.2 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase UCH PF00443.24 ESA07057.1 - 1.2e-20 73.7 0.2 2e-20 73.0 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA07057.1 - 1.2e-15 57.7 0.0 1.9e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 ESA07057.1 - 8.8e-09 35.6 0.7 2e-08 34.4 0.1 1.8 2 0 0 2 2 2 1 MATH domain DUF4413 PF14372.1 ESA07058.1 - 1.2e-08 34.8 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Eaf7 PF07904.8 ESA07058.1 - 0.17 11.8 1.7 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Dimer_Tnp_hAT PF05699.9 ESA07059.1 - 1.2e-22 79.3 0.1 1.4e-22 79.1 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RALF PF05498.6 ESA07060.1 - 0.074 13.8 0.1 0.11 13.3 0.1 1.4 1 0 0 1 1 1 0 Rapid ALkalinization Factor (RALF) Ras PF00071.17 ESA07062.1 - 1.8e-51 173.7 0.0 2.1e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA07062.1 - 3.7e-18 66.1 0.0 5.6e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA07062.1 - 2.7e-05 23.4 0.0 3.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA07062.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Exo_endo_phos PF03372.18 ESA07063.1 - 0.00015 21.7 0.2 0.00022 21.2 0.2 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TGT PF01702.13 ESA07063.1 - 0.081 12.1 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase Abhydrolase_6 PF12697.2 ESA07064.1 - 3.9e-12 46.5 0.0 7e-12 45.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA07064.1 - 1.6e-07 31.2 0.0 4.8e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA07064.1 - 0.00044 19.8 0.0 0.0016 18.0 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold ATXN-1_C PF12547.3 ESA07064.1 - 0.15 12.0 2.9 4.7 7.2 0.9 2.5 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator UBX PF00789.15 ESA07065.1 - 3.1e-16 59.1 0.7 1.1e-15 57.4 0.1 2.2 2 0 0 2 2 2 1 UBX domain UBA PF00627.26 ESA07065.1 - 2.1e-06 27.3 0.0 4.7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2_2 PF12756.2 ESA07065.1 - 0.042 13.9 2.8 0.061 13.4 0.8 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) SOBP PF15279.1 ESA07065.1 - 0.3 11.4 4.2 0.37 11.1 2.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein UQ_con PF00179.21 ESA07066.1 - 1.6e-31 108.6 0.1 1.9e-31 108.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA07066.1 - 4.7e-06 26.3 0.0 5.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA07066.1 - 0.0011 18.8 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.6 ESA07066.1 - 0.066 12.6 0.0 0.14 11.5 0.0 1.5 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Amidohydro_1 PF01979.15 ESA07067.1 - 3.4e-13 49.9 0.0 5.9e-08 32.7 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 ESA07067.1 - 4.4e-12 46.6 0.0 4.7e-05 23.5 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_5 PF13594.1 ESA07067.1 - 5.1e-05 22.9 0.0 0.00017 21.2 0.0 1.9 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ESA07067.1 - 0.00014 21.1 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family Aldo_ket_red PF00248.16 ESA07067.1 - 0.12 11.1 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Aldo/keto reductase family Pex24p PF06398.6 ESA07068.1 - 2.6e-25 89.0 0.2 2.6e-25 89.0 0.1 1.5 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin C1_1 PF00130.17 ESA07068.1 - 1e-09 37.9 12.5 1.7e-09 37.2 8.7 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SecE PF00584.15 ESA07068.1 - 0.028 14.0 1.4 0.068 12.7 0.9 1.7 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DUF639 PF04842.7 ESA07068.1 - 0.042 12.0 0.3 0.071 11.2 0.2 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) DUF2649 PF10854.3 ESA07068.1 - 1.2 9.2 9.0 0.081 13.0 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) Sel1 PF08238.7 ESA07069.1 - 1.5e-43 146.2 19.4 1.5e-07 31.8 0.0 8.1 8 0 0 8 8 8 6 Sel1 repeat TPR_16 PF13432.1 ESA07069.1 - 0.00075 20.0 4.8 0.38 11.5 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESA07069.1 - 0.0024 18.2 4.3 1.4 9.4 0.0 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat DUF3531 PF12049.3 ESA07069.1 - 0.029 14.0 0.0 0.24 11.0 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3531) TPR_12 PF13424.1 ESA07069.1 - 0.063 13.2 4.9 1.2 9.0 0.0 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat Glyco_hydro_9 PF00759.14 ESA07070.1 - 5.4e-117 391.4 8.0 6.2e-117 391.2 5.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 DUF1481 PF07356.7 ESA07070.1 - 0.057 12.8 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1481) DUF3684 PF12449.3 ESA07071.1 - 2.1e-236 787.2 21.9 4.5e-221 736.5 13.0 4.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA07071.1 - 0.00045 19.8 0.1 0.00045 19.8 0.1 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA07071.1 - 0.032 13.9 0.1 0.08 12.6 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aldo_ket_red PF00248.16 ESA07073.1 - 2.7e-48 164.2 0.0 3.1e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4218 PF13960.1 ESA07075.1 - 3.8e-05 23.1 0.1 5.6e-05 22.5 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4218) C-C_Bond_Lyase PF15617.1 ESA07075.1 - 0.02 13.7 0.0 0.023 13.4 0.0 1.0 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold Sel1 PF08238.7 ESA07076.1 - 5.2e-42 141.3 8.4 2e-10 40.9 0.3 5.1 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA07076.1 - 1.1 9.1 3.9 46 3.9 0.0 3.4 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA07076.1 - 1.2 8.8 7.0 2.2 7.9 0.8 3.3 3 1 0 3 3 3 0 TPR repeat DUF3965 PF13112.1 ESA07077.1 - 0.037 13.2 1.0 0.043 12.9 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) BTB PF00651.26 ESA07078.1 - 5.5e-08 32.7 0.2 3.4e-07 30.2 0.0 2.1 1 1 1 2 2 2 1 BTB/POZ domain DUF2682 PF10909.3 ESA07078.1 - 0.02 15.1 0.4 0.02 15.1 0.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2682) DUF1247 PF06851.6 ESA07078.1 - 0.13 11.9 1.1 0.26 10.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) VTC PF09359.5 ESA07079.1 - 1.3e-87 293.4 4.1 2.2e-87 292.6 2.8 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 ESA07079.1 - 1.7e-21 77.2 11.8 8e-14 52.0 4.1 4.6 2 2 1 3 3 3 2 SPX domain DUF202 PF02656.10 ESA07079.1 - 1.4e-12 47.6 0.5 2.5e-12 46.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF202) DUF2533 PF10752.4 ESA07079.1 - 0.084 13.1 1.4 1.6 9.0 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2533) DUF1664 PF07889.7 ESA07079.1 - 0.15 11.8 3.4 1.4 8.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.1 ESA07079.1 - 0.16 12.0 2.1 6.6 6.8 0.2 2.7 2 0 0 2 2 2 0 Syntaxin-like protein CBFB_NFYA PF02045.10 ESA07080.1 - 1.2e-30 105.8 8.8 1.2e-30 105.8 6.1 1.7 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B SIT PF15330.1 ESA07080.1 - 7.6 6.7 7.2 2.3 8.4 0.6 2.7 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF3774 PF12609.3 ESA07080.1 - 8.3 7.3 6.8 3.7 8.4 2.4 2.2 2 0 0 2 2 2 0 Wound-induced protein Ammonium_transp PF00909.16 ESA07081.1 - 3.8e-115 384.5 20.2 4.4e-115 384.3 14.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Herpes_UL74 PF07982.7 ESA07084.1 - 0.015 13.9 1.0 0.016 13.8 0.7 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins DDA1 PF10172.4 ESA07085.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Det1 complexing ubiquitin ligase Transpos_assoc PF13963.1 ESA07085.1 - 0.15 12.0 1.0 0.18 11.7 0.7 1.1 1 0 0 1 1 1 0 Transposase-associated domain zf-C2H2_4 PF13894.1 ESA07085.1 - 0.21 11.9 0.5 0.21 11.9 0.3 2.7 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA07085.1 - 1.6 9.2 8.3 5 7.6 0.5 3.2 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA07085.1 - 4.5 7.7 8.6 2.1 8.8 0.8 2.7 2 2 0 2 2 2 0 Zinc-finger double domain DBD_Tnp_Mut PF03108.10 ESA07085.1 - 8.2 6.0 7.9 4.9 6.8 1.9 2.3 2 1 0 2 2 2 0 MuDR family transposase Tol_Tol_Ttg2 PF05494.7 ESA07086.1 - 0.065 12.7 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 CAF1A PF12253.3 ESA07086.1 - 0.28 11.2 4.7 11 6.1 1.3 2.5 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A SEP PF08059.8 ESA07089.1 - 3.3e-29 100.9 0.0 1.1e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 SEP domain UBX PF00789.15 ESA07089.1 - 1.6e-17 63.2 0.1 2.7e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 UBX domain Sld5 PF05916.6 ESA07090.1 - 0.024 14.9 1.3 0.051 13.8 0.8 1.8 1 1 0 1 1 1 0 GINS complex protein DUF3347 PF11827.3 ESA07090.1 - 0.026 14.5 0.2 0.26 11.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) RsbU_N PF08673.5 ESA07090.1 - 0.035 14.1 1.1 2.3 8.2 0.1 2.5 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain MetJ PF01340.15 ESA07090.1 - 0.063 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Met Apo-repressor, MetJ p450 PF00067.17 ESA07091.1 - 6.5e-08 31.5 0.0 6.6e-08 31.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 E1-E2_ATPase PF00122.15 ESA07092.1 - 9.2e-54 181.9 2.9 2.4e-53 180.5 2.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESA07092.1 - 8e-51 173.4 0.7 1.7e-50 172.3 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 ESA07092.1 - 5.1e-32 109.8 5.0 2.6e-12 46.6 1.1 3.8 3 0 0 3 3 3 3 Heavy-metal-associated domain HAD PF12710.2 ESA07092.1 - 1.9e-17 64.0 0.0 3.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA07092.1 - 3.8e-05 23.3 2.7 0.00088 18.9 0.9 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Pex14_N PF04695.8 ESA07092.1 - 0.011 15.8 1.9 0.026 14.5 1.3 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_assoc_C PF09821.4 ESA07093.1 - 0.016 15.4 0.0 0.02 15.1 0.0 1.0 1 0 0 1 1 1 0 C-terminal AAA-associated domain DUF3635 PF12330.3 ESA07094.1 - 0.032 14.2 3.4 0.039 14.0 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3635) Prefoldin PF02996.12 ESA07094.1 - 0.1 12.2 6.4 0.17 11.5 0.3 2.5 1 1 1 2 2 2 0 Prefoldin subunit DUF1599 PF07659.6 ESA07094.1 - 0.18 11.9 0.2 0.18 11.9 0.2 3.2 3 1 1 4 4 4 0 Domain of Unknown Function (DUF1599) DNA_pol_alpha_N PF12254.3 ESA07094.1 - 0.35 10.7 4.1 0.35 10.7 0.9 2.4 1 1 1 2 2 2 0 DNA polymerase alpha subunit p180 N terminal PKD_channel PF08016.7 ESA07096.1 - 0.0053 15.2 6.1 0.0084 14.5 4.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel HMG_box_2 PF09011.5 ESA07097.1 - 4.5e-07 30.1 2.1 0.00058 20.1 0.0 3.9 4 0 0 4 4 4 2 HMG-box domain HMG_box PF00505.14 ESA07097.1 - 3.1e-05 24.1 7.0 0.5 10.6 0.1 4.2 4 0 0 4 4 4 2 HMG (high mobility group) box Glycoamylase PF10091.4 ESA07097.1 - 0.0018 17.4 0.1 1.6 7.7 0.0 2.2 2 0 0 2 2 2 2 Putative glucoamylase Inhibitor_G39P PF11417.3 ESA07097.1 - 0.047 13.6 0.5 10 6.1 0.0 3.3 3 0 0 3 3 3 0 Loader and inhibitor of phage G40P DUF3893 PF13032.1 ESA07097.1 - 0.48 10.5 7.1 9.1 6.4 1.0 3.3 3 1 2 5 5 5 0 Domain of unknown function (DUF3893) PP2C PF00481.16 ESA07098.1 - 0.0012 18.3 0.1 0.0022 17.4 0.0 1.5 1 1 1 2 2 2 1 Protein phosphatase 2C OST3_OST6 PF04756.8 ESA07099.1 - 1.1e-19 70.6 6.1 1.1e-18 67.3 5.7 1.6 2 0 0 2 2 2 1 OST3 / OST6 family Thioredoxin PF00085.15 ESA07099.1 - 0.01 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF1113 PF06541.6 ESA07099.1 - 0.044 13.5 6.0 0.083 12.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1113) DUF4131 PF13567.1 ESA07099.1 - 0.11 11.9 5.1 0.37 10.1 0.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF4149 PF13664.1 ESA07099.1 - 3 7.9 10.6 4.2 7.5 0.9 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4149) Use1 PF09753.4 ESA07101.1 - 1.4e-34 119.7 11.7 1.6e-34 119.5 8.1 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF3596 PF12167.3 ESA07101.1 - 0.068 12.7 0.1 0.21 11.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3596) DUF2269 PF10027.4 ESA07101.1 - 0.073 12.8 1.5 0.16 11.7 1.0 1.5 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) DUF2252 PF10009.4 ESA07101.1 - 0.19 10.6 3.4 0.23 10.3 2.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) ZYG-11_interact PF05884.7 ESA07101.1 - 0.37 9.8 2.2 6.4 5.7 0.2 2.1 2 0 0 2 2 2 0 Interactor of ZYG-11 DUF3020 PF11223.3 ESA07101.1 - 0.41 11.0 3.4 4 7.9 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3020) DUF2649 PF10854.3 ESA07101.1 - 2.6 8.2 7.8 8.4 6.5 4.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) zf-CCHC_2 PF13696.1 ESA07103.1 - 0.0039 16.6 1.2 0.0078 15.6 0.9 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.3 ESA07103.1 - 0.021 14.7 0.6 0.021 14.7 0.4 2.3 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 ESA07103.1 - 7.1 6.7 9.3 1.1 9.2 3.6 1.9 2 0 0 2 2 2 0 Zinc knuckle Git3_C PF11970.3 ESA07104.1 - 0.0019 17.9 0.9 0.0019 17.9 0.6 3.4 4 1 0 4 4 4 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF3566 PF12089.3 ESA07104.1 - 1.3 9.0 7.7 0.55 10.2 1.0 2.7 2 0 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) DUF3754 PF12576.3 ESA07104.1 - 1.8 8.2 9.7 0.031 13.9 1.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3754) DctQ PF04290.7 ESA07104.1 - 2.1 8.0 11.2 1.5 8.5 6.0 2.0 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component RNA_pol_Rbc25 PF08292.7 ESA07104.1 - 2.6 8.2 7.5 0.51 10.5 1.5 2.3 1 1 1 2 2 2 0 RNA polymerase III subunit Rpc25 zf-C2H2_4 PF13894.1 ESA07106.1 - 0.0035 17.5 0.3 0.011 16.0 0.0 2.0 2 1 0 2 2 2 1 C2H2-type zinc finger TerY-C PF15616.1 ESA07106.1 - 0.025 14.5 0.8 0.027 14.3 0.5 1.2 1 1 0 1 1 1 0 TerY-C metal binding domain zf-C2HC_2 PF13913.1 ESA07106.1 - 0.069 12.8 0.7 0.12 12.0 0.5 1.5 1 1 0 1 1 1 0 zinc-finger of a C2HC-type zf-ribbon_3 PF13248.1 ESA07106.1 - 1.2 8.4 4.1 0.38 10.0 0.9 1.7 2 0 0 2 2 2 0 zinc-ribbon domain DUF3545 PF12065.3 ESA07107.1 - 0.11 12.2 0.6 0.13 12.0 0.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3545) Histone PF00125.19 ESA07109.1 - 2.5e-31 107.6 0.5 3.8e-31 107.0 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA07109.1 - 1.2e-05 25.3 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA07109.1 - 0.0024 17.8 0.1 0.0049 16.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESA07109.1 - 0.0099 15.5 0.1 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated DUF900 PF05990.7 ESA07110.1 - 9.8e-18 64.3 0.0 1.7e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.2 ESA07110.1 - 0.00071 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA07110.1 - 0.0017 18.1 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA07110.1 - 0.015 14.8 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold YjgP_YjgQ PF03739.9 ESA07110.1 - 0.018 13.8 4.3 0.069 11.8 0.8 2.2 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family DUF4239 PF14023.1 ESA07110.1 - 0.02 14.2 0.3 0.57 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF2207 PF09972.4 ESA07110.1 - 0.69 8.4 7.6 1.5 7.3 5.3 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) LRR_6 PF13516.1 ESA07111.1 - 0.00079 19.2 10.0 0.029 14.4 0.1 5.5 6 0 0 6 6 6 2 Leucine Rich repeat zf-CCHC_4 PF14392.1 ESA07111.1 - 0.023 14.3 1.5 0.049 13.3 0.4 2.0 2 0 0 2 2 2 0 Zinc knuckle LRR_4 PF12799.2 ESA07111.1 - 0.24 11.0 0.1 0.24 11.0 0.1 3.3 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) GBP PF02263.14 ESA07112.1 - 1.3e-41 142.4 0.6 6.6e-41 140.0 0.0 2.5 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain DNA_pol_B_palm PF14792.1 ESA07112.1 - 0.0074 16.3 0.6 6.8 6.7 0.0 3.7 3 0 0 3 3 3 1 DNA polymerase beta palm MMR_HSR1 PF01926.18 ESA07112.1 - 0.058 13.3 0.5 0.42 10.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase PhrC_PhrF PF11131.3 ESA07112.1 - 0.084 12.4 0.6 0.17 11.4 0.4 1.5 1 0 0 1 1 1 0 Rap-phr extracellular signalling Dynamin_N PF00350.18 ESA07112.1 - 2 8.2 0.0 2 8.2 0.0 3.4 3 1 0 3 3 3 0 Dynamin family MutH PF02976.10 ESA07115.1 - 0.031 14.1 0.0 0.066 13.0 0.0 1.6 1 0 0 1 1 1 0 DNA mismatch repair enzyme MutH Sel1 PF08238.7 ESA07117.1 - 4.8e-41 138.2 19.2 8.1e-12 45.3 0.3 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA07117.1 - 0.14 12.7 2.4 0.69 10.5 0.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA07117.1 - 4.1 7.3 11.3 2.5 8.0 1.3 4.1 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain LRR_8 PF13855.1 ESA07118.1 - 0.012 15.2 13.3 0.32 10.7 0.1 4.4 4 0 0 4 4 4 0 Leucine rich repeat DKNYY PF13644.1 ESA07118.1 - 0.13 12.5 2.0 0.37 11.0 0.1 2.0 2 1 0 2 2 2 0 DKNYY family Pkinase_Tyr PF07714.12 ESA07119.1 - 9.2e-37 126.5 0.0 1.2e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07119.1 - 1.1e-33 116.5 0.0 1.7e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07119.1 - 0.0013 17.8 0.1 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA07119.1 - 0.0049 15.8 0.0 0.0069 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA07119.1 - 0.027 13.8 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family WaaY PF06176.6 ESA07119.1 - 0.048 12.8 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA07119.1 - 0.11 12.2 0.3 0.16 11.7 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Galactosyl_T PF01762.16 ESA07121.1 - 6e-10 39.0 0.1 2.3e-08 33.8 0.2 2.1 1 1 1 2 2 2 2 Galactosyltransferase Pkinase_Tyr PF07714.12 ESA07122.1 - 8.6e-22 77.4 0.0 9.5e-22 77.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07122.1 - 8.9e-18 64.3 0.0 1.2e-17 63.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF4468 PF14730.1 ESA07122.1 - 0.076 12.7 0.3 0.15 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold AAA_17 PF13207.1 ESA07123.1 - 0.016 16.0 2.8 0.047 14.5 0.1 3.0 2 2 0 2 2 2 0 AAA domain PTPS PF01242.14 ESA07123.1 - 0.04 13.5 0.6 2.3 7.8 0.0 2.5 2 1 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase RNA_helicase PF00910.17 ESA07123.1 - 0.059 13.5 0.1 0.31 11.2 0.0 2.3 2 1 0 2 2 2 0 RNA helicase AAA_14 PF13173.1 ESA07123.1 - 0.087 12.7 1.5 0.3 11.0 0.1 2.5 2 1 0 3 3 3 0 AAA domain AAA_18 PF13238.1 ESA07123.1 - 0.19 12.0 0.0 0.19 12.0 0.0 2.9 3 1 0 3 3 3 0 AAA domain Pkinase_Tyr PF07714.12 ESA07124.1 - 1e-29 103.3 0.0 1.2e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07124.1 - 5.4e-25 88.0 0.0 7.2e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain HMG_box PF00505.14 ESA07125.1 - 6.8e-08 32.6 0.9 1.8e-07 31.3 0.7 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07125.1 - 2.5e-05 24.5 0.7 5.8e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 HMG-box domain Myb_DNA-bind_3 PF12776.2 ESA07128.1 - 0.03 14.9 3.7 0.057 14.0 2.2 1.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Retrotrans_gag PF03732.12 ESA07128.1 - 0.22 11.6 2.2 0.22 11.6 0.7 1.6 2 0 0 2 2 2 0 Retrotransposon gag protein Gti1_Pac2 PF09729.4 ESA07129.1 - 6.2e-60 201.8 0.4 1.1e-59 201.0 0.3 1.4 1 1 0 1 1 1 1 Gti1/Pac2 family Flu_PB2 PF00604.12 ESA07130.1 - 0.1 10.4 0.0 0.12 10.1 0.0 1.0 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 Vezatin PF12632.2 ESA07131.1 - 0.017 14.2 0.1 0.037 13.0 0.0 1.6 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes GIDE PF12483.3 ESA07131.1 - 0.027 13.8 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 E3 Ubiquitin ligase DEAD PF00270.24 ESA07132.1 - 1.1e-18 67.2 0.0 6.6e-18 64.7 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA07132.1 - 7.8e-09 35.6 0.0 3.9e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESA07132.1 - 1e-06 28.5 0.0 2.8e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Glyco_hydro_66 PF13199.1 ESA07132.1 - 0.12 10.7 0.0 0.2 10.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 DUF4613 PF15390.1 ESA07133.1 - 0.12 10.5 8.1 0.15 10.2 5.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) p450 PF00067.17 ESA07134.1 - 8.5e-33 113.5 0.5 9.4e-33 113.4 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 PqiA PF04403.8 ESA07134.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Paraquat-inducible protein A Arrestin_C PF02752.17 ESA07134.1 - 0.094 12.8 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain BCCT PF02028.12 ESA07136.1 - 0.022 13.0 0.3 0.034 12.3 0.2 1.3 1 0 0 1 1 1 0 BCCT family transporter DUF3684 PF12449.3 ESA07138.1 - 7.4e-23 80.1 0.1 9.8e-21 73.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3684) DUF4483 PF14825.1 ESA07139.1 - 0.0018 17.9 0.1 0.048 13.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4483) Pkinase_Tyr PF07714.12 ESA07139.1 - 0.0038 16.3 0.0 0.88 8.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PA14_2 PF10528.4 ESA07139.1 - 0.064 13.2 1.4 2.4 8.1 0.1 2.6 2 0 0 2 2 2 0 GLEYA domain Rota_NSP3 PF01665.11 ESA07139.1 - 0.55 9.1 11.7 0.084 11.8 1.0 2.2 1 1 0 2 2 2 0 Rotavirus non-structural protein NSP3 Baculo_p47 PF05112.7 ESA07143.1 - 0.049 13.0 6.2 0.062 12.6 4.3 1.2 1 1 0 1 1 1 0 Baculovirus P47 protein Hema_stalk PF08720.5 ESA07143.1 - 0.12 11.8 1.1 0.19 11.2 0.7 1.4 1 1 0 1 1 1 0 Influenza C hemagglutinin stalk LAGLIDADG_1 PF00961.14 ESA07143.1 - 0.12 12.8 8.1 3 8.4 1.7 2.1 2 0 0 2 2 2 0 LAGLIDADG endonuclease ubiquitin PF00240.18 ESA07144.1 - 2.5e-33 113.2 4.5 2.8e-17 61.8 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA07144.1 - 6.3e-22 77.0 4.8 2.1e-10 40.1 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA07144.1 - 1.9e-07 31.2 5.6 0.00034 20.7 0.6 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain APG12 PF04110.8 ESA07144.1 - 0.025 14.7 1.2 1.1 9.5 0.1 2.4 2 1 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 UN_NPL4 PF11543.3 ESA07144.1 - 0.065 13.5 2.3 0.22 11.8 0.2 2.2 1 1 1 2 2 2 0 Nuclear pore localisation protein NPL4 YfmQ PF10787.4 ESA07144.1 - 0.14 11.4 1.4 0.26 10.6 0.7 1.6 1 1 1 2 2 2 0 Uncharacterised protein from bacillus cereus group ThiS-like PF14453.1 ESA07144.1 - 0.28 11.0 3.5 1.4 8.7 0.2 3.0 3 1 0 3 3 3 0 ThiS-like ubiquitin IBR PF01485.16 ESA07145.1 - 4.3e-14 52.1 38.5 3.3e-07 30.0 8.6 3.9 3 1 1 4 4 4 3 IBR domain ubiquitin PF00240.18 ESA07146.1 - 1.1e-34 117.6 5.6 1.6e-17 62.6 1.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA07146.1 - 1.3e-19 69.6 5.4 8.4e-11 41.4 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA07146.1 - 1.2e-06 28.6 3.3 4.4e-05 23.6 1.2 2.3 1 1 1 2 2 2 1 Ubiquitin-like domain TUG-UBL1 PF11470.3 ESA07146.1 - 0.00051 19.9 0.6 0.00086 19.1 0.1 1.6 2 1 0 2 2 2 1 GLUT4 regulating protein TUG Rad60-SLD_2 PF13881.1 ESA07146.1 - 0.0034 17.2 0.2 0.27 11.1 0.1 2.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like GABP-alpha PF11620.3 ESA07146.1 - 0.01 15.8 3.8 0.35 10.9 2.4 2.2 1 1 1 2 2 2 0 GA-binding protein alpha chain DUF2407 PF10302.4 ESA07146.1 - 0.012 15.7 0.5 0.69 10.1 0.3 2.2 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain YfmQ PF10787.4 ESA07146.1 - 0.014 14.7 1.2 0.11 11.8 0.9 1.9 1 1 1 2 2 2 0 Uncharacterised protein from bacillus cereus group DUF2870 PF11069.3 ESA07146.1 - 0.036 14.1 1.4 1.9 8.5 0.4 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2870) UN_NPL4 PF11543.3 ESA07146.1 - 0.08 13.2 1.3 0.14 12.4 0.1 1.9 2 1 0 2 2 2 0 Nuclear pore localisation protein NPL4 IBR PF01485.16 ESA07147.1 - 7e-10 38.6 4.2 7e-10 38.6 2.9 4.1 3 1 1 4 4 4 3 IBR domain RNaseH_C PF09293.5 ESA07147.1 - 0.0034 17.2 0.1 0.007 16.2 0.0 1.4 1 0 0 1 1 1 1 T4 RNase H, C terminal zf-C3HC4_2 PF13923.1 ESA07147.1 - 0.0089 16.0 10.6 0.0089 16.0 7.3 3.7 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.1 ESA07147.1 - 0.94 8.7 0.0 0.94 8.7 0.0 5.2 6 0 0 6 6 6 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA07147.1 - 2.9 7.4 14.1 27 4.4 0.2 5.3 5 1 0 5 5 5 0 zinc-ribbon domain CTK3 PF12243.3 ESA07150.1 - 0.071 12.7 2.1 0.39 10.3 0.6 2.0 1 1 1 2 2 2 0 CTD kinase subunit gamma CTK3 DUF2935 PF11155.3 ESA07150.1 - 0.18 11.8 1.3 0.36 10.9 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) DUF4078 PF13300.1 ESA07151.1 - 0.089 12.9 5.3 1.2 9.2 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4078) CAP_N PF01213.14 ESA07152.1 - 0.00027 20.3 9.2 0.00027 20.3 6.4 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 ESA07152.1 - 0.32 10.3 11.9 0.3 10.4 8.3 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Pap_E4 PF02711.9 ESA07152.1 - 1.7 9.5 5.8 1.7 9.5 4.0 1.1 1 0 0 1 1 1 0 E4 protein DUF2985 PF11204.3 ESA07153.1 - 2e-06 27.4 1.5 2e-06 27.4 1.0 2.1 3 1 1 4 4 4 1 Protein of unknown function (DUF2985) Sec20 PF03908.8 ESA07154.1 - 0.087 12.5 2.6 0.17 11.6 1.8 1.4 1 0 0 1 1 1 0 Sec20 Securin PF04856.8 ESA07157.1 - 0.031 13.9 0.1 0.043 13.5 0.1 1.3 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor Sel1 PF08238.7 ESA07158.1 - 3.3e-69 227.7 17.7 4.7e-12 46.1 0.5 7.0 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA07158.1 - 0.00066 19.9 5.4 2.1 8.9 0.1 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA07158.1 - 0.0052 17.4 0.0 5.5 7.7 0.0 4.0 3 2 3 6 6 6 1 Tetratricopeptide repeat SLT PF01464.15 ESA07158.1 - 0.018 14.5 12.9 0.49 9.8 0.5 4.5 1 1 5 6 6 6 0 Transglycosylase SLT domain TPR_11 PF13414.1 ESA07158.1 - 0.02 14.5 11.4 0.51 10.0 0.3 4.8 2 1 4 6 6 6 0 TPR repeat MIT PF04212.13 ESA07158.1 - 0.36 10.7 4.4 5.8 6.8 0.2 4.4 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA07158.1 - 0.46 10.8 6.9 16 5.9 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat P35 PF02331.10 ESA07158.1 - 1 8.4 6.3 0.75 8.8 0.2 2.2 2 1 0 2 2 2 0 Apoptosis preventing protein zf-B_box PF00643.19 ESA07159.1 - 0.035 13.9 0.7 0.071 13.0 0.5 1.5 1 0 0 1 1 1 0 B-box zinc finger BTB PF00651.26 ESA07160.1 - 3.8e-20 71.9 0.1 4.6e-20 71.6 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA07160.1 - 0.0081 15.3 0.2 0.0081 15.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Glyco_trans_2_3 PF13632.1 ESA07161.1 - 4.1e-15 56.0 2.9 4.1e-15 56.0 2.0 3.0 4 1 0 4 4 4 1 Glycosyl transferase family group 2 Sel1 PF08238.7 ESA07162.1 - 2.4e-25 88.4 1.7 4.3e-07 30.3 0.0 4.3 4 0 0 4 4 4 4 Sel1 repeat Pkinase_Tyr PF07714.12 ESA07162.1 - 9e-14 51.1 0.0 1.4e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07162.1 - 2.8e-09 36.5 0.0 7.4e-09 35.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA07162.1 - 0.00088 19.5 0.3 0.92 10.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA07162.1 - 0.0085 16.2 0.6 3.5 8.0 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Nbl1_Borealin_N PF10444.4 ESA07162.1 - 0.019 14.3 0.2 0.041 13.2 0.1 1.5 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal DUF4004 PF13171.1 ESA07162.1 - 0.033 14.3 1.7 0.079 13.1 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4004) GRAB PF10375.4 ESA07163.1 - 0.098 12.3 11.5 11 5.9 0.0 5.2 5 0 0 5 5 5 0 GRIP-related Arf-binding domain zf-MYND PF01753.13 ESA07164.1 - 1.8e-09 37.2 23.5 2.9e-09 36.6 16.3 1.3 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.1 ESA07164.1 - 0.017 14.9 12.4 0.031 14.1 8.6 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-HIT PF04438.11 ESA07164.1 - 0.33 10.6 16.3 0.52 9.9 11.3 1.3 1 0 0 1 1 1 0 HIT zinc finger DUF2203 PF09969.4 ESA07166.1 - 0.0028 17.8 1.4 0.019 15.2 0.0 2.3 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2203) Erp_C PF06780.6 ESA07166.1 - 0.0039 17.0 2.6 0.0063 16.3 1.8 1.4 1 0 0 1 1 1 1 Erp protein C-terminus Ashwin PF15323.1 ESA07166.1 - 0.072 13.0 10.6 0.093 12.7 7.4 1.1 1 0 0 1 1 1 0 Developmental protein FlaG PF03646.10 ESA07166.1 - 0.091 12.9 11.0 0.26 11.4 4.7 2.3 2 0 0 2 2 2 0 FlaG protein Activator-TraM PF11657.3 ESA07166.1 - 0.24 10.8 3.0 8.7 5.8 1.2 2.2 1 1 1 2 2 2 0 Transcriptional activator TraM Neur_chan_memb PF02932.11 ESA07166.1 - 0.5 10.2 7.8 0.64 9.8 5.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mif2_N PF15624.1 ESA07166.1 - 1.8 9.1 14.2 2.7 8.5 9.9 1.3 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Presenilin PF01080.12 ESA07166.1 - 2.5 6.8 8.5 3.1 6.5 5.9 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.5 ESA07166.1 - 3.4 5.9 7.8 3.8 5.8 5.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDHD PF02862.12 ESA07166.1 - 5.4 6.7 10.2 7 6.3 7.1 1.2 1 0 0 1 1 1 0 DDHD domain Pkinase_Tyr PF07714.12 ESA07169.1 - 1.4e-52 178.3 0.0 1.6e-52 178.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07169.1 - 3.3e-47 160.8 0.0 3.9e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA07169.1 - 0.002 17.5 0.2 0.003 16.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA07169.1 - 0.0023 17.0 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA07169.1 - 0.014 15.1 0.1 0.024 14.3 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family ABC1 PF03109.11 ESA07169.1 - 0.035 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC1 family Sel1 PF08238.7 ESA07170.1 - 1.2e-07 32.1 0.1 2.2e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Sel1 repeat PAS_3 PF08447.6 ESA07171.1 - 1.8e-10 40.7 0.0 3.3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.1 ESA07171.1 - 1.5e-07 31.6 0.0 2.8e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 ESA07171.1 - 8e-06 25.6 0.0 1.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.1 ESA07171.1 - 0.0024 17.8 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 PAS domain TFIIA_gamma_C PF02751.9 ESA07172.1 - 1e-26 92.4 0.2 1.6e-26 91.8 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 ESA07172.1 - 2.9e-26 90.7 0.1 3.8e-26 90.4 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain GLTP PF08718.6 ESA07173.1 - 6.9e-39 133.2 0.0 8.7e-39 132.9 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF576 PF04507.7 ESA07173.1 - 0.031 13.2 1.1 3.5 6.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF576 DUF1798 PF08807.5 ESA07173.1 - 0.15 11.7 0.6 0.28 10.9 0.1 1.6 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) RBFA PF02033.13 ESA07177.1 - 5.8e-08 32.7 0.0 2.4e-07 30.7 0.0 2.0 1 1 1 2 2 2 1 Ribosome-binding factor A Peptidase_M73 PF12389.3 ESA07177.1 - 0.016 14.6 0.3 0.024 14.1 0.2 1.3 1 0 0 1 1 1 0 Camelysin metallo-endopeptidase CorA PF01544.13 ESA07177.1 - 0.36 9.7 4.0 2.4 7.1 0.1 2.4 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Sugar_tr PF00083.19 ESA07178.1 - 0.0005 18.7 0.2 0.00058 18.5 0.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DEAD PF00270.24 ESA07180.1 - 2.2e-42 144.4 0.1 2.3e-41 141.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA07180.1 - 2e-22 78.8 0.0 6e-22 77.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-HIT PF04438.11 ESA07180.1 - 2e-08 33.7 2.2 4.2e-08 32.6 1.5 1.6 1 0 0 1 1 1 1 HIT zinc finger ResIII PF04851.10 ESA07180.1 - 0.00068 19.5 0.0 0.0018 18.1 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF329 PF03884.9 ESA07180.1 - 0.11 12.0 0.4 0.24 10.9 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF329) Amidohydro_4 PF13147.1 ESA07181.1 - 9.7e-20 71.7 0.6 6.7e-17 62.4 0.0 3.6 3 1 0 3 3 3 2 Amidohydrolase Amidohydro_5 PF13594.1 ESA07181.1 - 7.7e-14 51.2 3.4 1e-09 38.0 0.1 2.8 2 0 0 2 2 2 2 Amidohydrolase Amidohydro_1 PF01979.15 ESA07181.1 - 1.7e-12 47.6 0.7 4.7e-09 36.3 0.0 2.9 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_3 PF07969.6 ESA07181.1 - 1.2e-08 34.6 0.7 1.7e-05 24.1 0.0 2.5 2 1 0 2 2 2 2 Amidohydrolase family BTB PF00651.26 ESA07185.1 - 0.0027 17.6 0.2 0.0045 16.9 0.2 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3040 PF11239.3 ESA07185.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) PIF1 PF05970.9 ESA07189.1 - 2.1e-07 30.2 0.0 2.3e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Pkinase PF00069.20 ESA07190.1 - 0.031 13.4 0.1 0.047 12.8 0.0 1.4 2 0 0 2 2 2 0 Protein kinase domain TRAM PF01938.15 ESA07191.1 - 0.1 12.3 0.1 5.6 6.8 0.0 2.4 2 0 0 2 2 2 0 TRAM domain ubiquitin PF00240.18 ESA07192.1 - 0.022 14.1 0.1 0.045 13.1 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin family Pkinase PF00069.20 ESA07194.1 - 4.9e-42 143.8 0.2 1.1e-41 142.7 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07194.1 - 1.5e-36 125.7 0.1 2.2e-36 125.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA07194.1 - 0.032 13.2 0.1 0.35 9.7 0.0 2.3 2 1 0 2 2 2 0 Kinase-like APH PF01636.18 ESA07194.1 - 0.033 13.9 0.2 0.058 13.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kelch_6 PF13964.1 ESA07195.1 - 9e-20 69.9 11.1 0.0033 17.5 0.1 5.4 3 1 2 5 5 5 5 Kelch motif Kelch_5 PF13854.1 ESA07195.1 - 4.7e-17 61.5 11.0 0.0003 20.6 0.0 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA07195.1 - 6.5e-17 61.0 21.7 0.00064 19.4 2.9 5.6 4 2 1 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA07195.1 - 3.9e-15 55.5 11.8 0.00073 19.6 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA07195.1 - 5.8e-11 41.7 14.7 0.0022 17.4 0.1 5.5 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA07195.1 - 7.7e-09 34.9 4.5 0.02 14.6 0.0 5.4 5 0 0 5 5 5 3 Kelch motif SH3_1 PF00018.23 ESA07199.1 - 3e-07 29.6 0.1 4.7e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA07199.1 - 1.1e-06 28.0 0.0 2e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA07199.1 - 6.6e-06 25.5 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Zip PF02535.17 ESA07199.1 - 0.094 11.7 0.3 0.13 11.2 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF418 PF04235.7 ESA07199.1 - 1.1 8.8 6.8 1.2 8.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF418) Pkinase_Tyr PF07714.12 ESA07200.1 - 7e-19 67.8 0.0 1.2e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07200.1 - 3.1e-16 59.3 0.0 5e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TPR_12 PF13424.1 ESA07201.1 - 1.3e-05 25.0 0.1 0.00016 21.5 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA07201.1 - 0.00023 20.6 2.1 0.0004 19.9 0.7 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA07201.1 - 0.0019 18.0 1.8 0.0054 16.5 0.2 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA07201.1 - 0.0086 16.3 0.2 0.037 14.3 0.0 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07201.1 - 0.044 13.4 0.0 0.092 12.4 0.0 1.7 1 0 0 1 1 1 0 TPR repeat TPR_7 PF13176.1 ESA07201.1 - 0.059 13.1 0.1 0.21 11.4 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat ApoLp-III PF07464.6 ESA07201.1 - 0.06 13.3 0.4 2 8.4 0.0 2.6 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Syja_N PF02383.13 ESA07201.1 - 0.076 11.7 0.1 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 SacI homology domain TPR_6 PF13174.1 ESA07201.1 - 0.19 12.2 0.6 2 9.0 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA07202.1 - 6.6e-42 143.4 0.1 8.1e-42 143.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07202.1 - 1.3e-38 132.5 0.0 1.6e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA07202.1 - 0.00012 21.1 0.0 0.0031 16.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA07202.1 - 0.0022 17.4 0.0 0.0068 15.7 0.0 1.7 2 0 0 2 2 2 1 RIO1 family WaaY PF06176.6 ESA07202.1 - 0.0052 16.0 0.0 0.0098 15.1 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA07202.1 - 0.0078 15.9 0.2 0.033 13.9 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Poxvirus PF06227.7 ESA07202.1 - 0.064 12.8 3.0 1.1 8.7 0.0 2.3 1 1 1 2 2 2 0 dsDNA Poxvirus LHC PF00556.15 ESA07203.1 - 2.8 7.8 6.8 20 5.1 0.2 3.0 2 0 0 2 2 2 0 Antenna complex alpha/beta subunit FAD_binding_4 PF01565.18 ESA07206.1 - 6.8e-23 80.6 0.0 1e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 ESA07206.1 - 3.4e-14 53.0 2.7 1.3e-13 51.1 1.9 1.8 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Chol_subst-bind PF09129.6 ESA07206.1 - 2.1e-09 36.9 1.2 4.1e-08 32.7 0.8 2.2 1 1 0 1 1 1 1 Cholesterol oxidase, substrate-binding XendoU PF09412.5 ESA07210.1 - 0.047 12.7 2.4 0.052 12.5 1.7 1.2 1 0 0 1 1 1 0 Endoribonuclease XendoU Cytokin_check_N PF10407.4 ESA07210.1 - 0.1 12.2 3.1 0.25 10.9 1.9 1.9 1 1 1 2 2 2 0 Cdc14 phosphatase binding protein N-terminus F-box-like PF12937.2 ESA07212.1 - 2.6e-06 27.0 0.5 8.1e-06 25.4 0.4 1.8 1 0 0 1 1 1 1 F-box-like Bombolitin PF08096.6 ESA07212.1 - 0.062 13.3 0.7 0.17 11.9 0.5 1.7 1 0 0 1 1 1 0 Bombolitin family DUF3446 PF11928.3 ESA07212.1 - 0.24 11.6 18.0 0.6 10.3 12.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) Pkinase_Tyr PF07714.12 ESA07213.1 - 2.9e-40 137.9 0.0 3.7e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07213.1 - 2e-37 128.7 0.0 3.5e-37 127.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA07213.1 - 3.6e-05 23.1 0.0 7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA07213.1 - 0.0012 17.9 0.1 0.0022 17.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA07213.1 - 0.051 12.7 0.2 0.085 12.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ESA07214.1 - 1.4e-33 114.5 21.5 1.8e-07 31.5 0.2 5.3 5 0 0 5 5 5 5 Sel1 repeat TPR_12 PF13424.1 ESA07214.1 - 0.03 14.2 7.1 6.9 6.6 0.2 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07214.1 - 0.093 12.3 12.5 1.4 8.6 1.6 3.2 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.1 ESA07214.1 - 0.12 13.1 4.1 1.4 9.6 0.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat PLDc PF00614.17 ESA07215.1 - 1.1e-10 40.9 0.1 2.4e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 Phospholipase D Active site motif PLDc_2 PF13091.1 ESA07215.1 - 0.00078 19.1 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain DYW_deaminase PF14432.1 ESA07215.1 - 0.022 14.7 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases zf-CCHC PF00098.18 ESA07220.1 - 0.0014 18.4 0.6 0.0021 17.9 0.4 1.3 1 0 0 1 1 1 1 Zinc knuckle TFIIS_C PF01096.13 ESA07220.1 - 0.076 12.6 0.3 0.14 11.7 0.2 1.4 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) Ku_PK_bind PF08785.6 ESA07221.1 - 0.031 14.1 0.7 0.038 13.8 0.5 1.1 1 0 0 1 1 1 0 Ku C terminal domain like SSV1_ORF_D-335 PF07935.6 ESA07221.1 - 0.1 12.3 0.7 0.26 11.0 0.2 1.8 2 0 0 2 2 2 0 ORF D-335-like protein F-box-like PF12937.2 ESA07222.1 - 8.6e-06 25.3 1.0 2.1e-05 24.1 0.1 2.1 2 0 0 2 2 2 1 F-box-like WD40 PF00400.27 ESA07223.1 - 7.8e-36 120.6 21.3 9.2e-08 31.6 0.1 13.1 14 0 0 14 14 14 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESA07223.1 - 0.00013 20.8 4.8 0.18 10.5 0.1 4.2 3 2 0 4 4 4 3 Nup133 N terminal like GTP_EFTU PF00009.22 ESA07224.1 - 7.9e-51 172.1 0.1 1.4e-50 171.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 ESA07224.1 - 6.6e-47 157.8 2.1 1.4e-46 156.8 1.5 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 ESA07224.1 - 7.6e-22 76.9 0.0 1.7e-21 75.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus SRPRB PF09439.5 ESA07224.1 - 7.2e-06 25.3 0.1 1.8e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.20 ESA07224.1 - 8.9e-06 25.7 0.1 2e-05 24.5 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA07224.1 - 1.6e-05 24.8 0.1 3.8e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.1 ESA07224.1 - 0.0034 17.2 0.0 0.0083 15.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.17 ESA07224.1 - 0.0065 15.8 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA07224.1 - 0.032 14.7 0.0 0.072 13.5 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein F-box-like PF12937.2 ESA07225.1 - 4.1e-12 45.6 1.7 1.3e-11 44.0 0.9 2.1 2 1 0 2 2 2 1 F-box-like F-box PF00646.28 ESA07225.1 - 6.2e-09 35.2 0.6 2.2e-08 33.5 0.4 1.9 1 0 0 1 1 1 1 F-box domain DDE_3 PF13358.1 ESA07226.1 - 2.1e-09 37.2 0.2 2.5e-09 37.0 0.2 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Transcrip_reg PF01709.15 ESA07227.1 - 3.2e-74 248.9 0.8 3.7e-74 248.7 0.6 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF853 PF05872.7 ESA07228.1 - 1.2 7.3 5.0 1.2 7.4 3.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CPSase_sm_chain PF00988.17 ESA07229.1 - 0.011 15.2 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain VIT PF08487.5 ESA07231.1 - 3.5e-12 46.0 0.9 8.5e-12 44.8 0.4 1.8 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.1 ESA07231.1 - 0.031 13.7 0.0 0.087 12.2 0.0 1.8 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain Pkinase_Tyr PF07714.12 ESA07232.1 - 8.7e-06 24.9 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07232.1 - 1.2e-05 24.6 0.0 2.9e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF605 PF04652.11 ESA07232.1 - 4.5 6.5 20.1 5.4 6.2 14.0 1.3 1 0 0 1 1 1 0 Vta1 like Daxx PF03344.10 ESA07232.1 - 9 4.6 41.7 12 4.2 28.9 1.1 1 0 0 1 1 1 0 Daxx Family DUF708 PF05341.6 ESA07233.1 - 0.031 14.0 0.6 7 6.4 0.0 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF708) Gag_p12 PF01141.13 ESA07233.1 - 0.28 11.3 2.6 25 5.1 0.1 3.5 2 1 2 4 4 4 0 Gag polyprotein, inner coat protein p12 YpzI PF14140.1 ESA07233.1 - 2.1 7.8 9.2 3.8 7.0 0.8 2.6 2 0 0 2 2 2 0 YpzI-like protein DUF2854 PF11016.3 ESA07234.1 - 0.066 12.7 0.1 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) Proteasome PF00227.21 ESA07235.1 - 2.1e-50 170.6 0.1 3.4e-50 169.9 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA07235.1 - 7.9e-13 47.4 0.2 1.3e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature AIG1 PF04548.11 ESA07236.1 - 5.2e-20 71.4 0.0 5.2e-20 71.4 0.0 2.1 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ESA07236.1 - 0.0013 18.6 0.1 0.0036 17.2 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Imm5 PF14423.1 ESA07236.1 - 0.018 14.6 1.0 0.051 13.1 0.0 2.0 2 0 0 2 2 2 0 Immunity protein Imm5 Dynamin_N PF00350.18 ESA07236.1 - 0.17 11.6 0.0 0.17 11.6 0.0 3.6 2 2 0 2 2 2 0 Dynamin family ABC_tran PF00005.22 ESA07237.1 - 2.5e-31 108.8 0.0 4.5e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESA07237.1 - 1.1e-05 24.8 2.4 0.00053 19.2 0.3 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain T2SE PF00437.15 ESA07237.1 - 0.00011 21.2 0.1 0.00022 20.2 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_21 PF13304.1 ESA07237.1 - 0.00028 20.9 0.8 0.11 12.3 0.4 2.4 1 1 1 2 2 2 2 AAA domain MobB PF03205.9 ESA07237.1 - 0.003 17.2 0.3 0.0089 15.7 0.2 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DUF87 PF01935.12 ESA07237.1 - 0.0041 16.9 0.1 0.011 15.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_18 PF13238.1 ESA07237.1 - 0.0051 17.1 0.1 0.014 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.12 ESA07237.1 - 0.0056 16.2 0.2 0.04 13.4 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Pox_A32 PF04665.7 ESA07237.1 - 0.0078 15.5 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_29 PF13555.1 ESA07237.1 - 0.0084 15.6 0.2 0.03 13.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain Miro PF08477.8 ESA07237.1 - 0.011 16.1 0.6 0.03 14.8 0.1 2.0 2 0 0 2 2 1 0 Miro-like protein AAA_17 PF13207.1 ESA07237.1 - 0.024 15.4 1.1 0.057 14.2 0.8 1.8 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 ESA07237.1 - 0.027 13.9 1.1 0.041 13.3 0.2 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 ESA07237.1 - 0.028 14.7 0.2 0.08 13.2 0.1 1.7 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.4 ESA07237.1 - 0.028 13.0 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.7 ESA07237.1 - 0.044 13.4 0.5 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.1 ESA07237.1 - 0.053 13.0 0.0 0.14 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESA07237.1 - 0.063 12.8 0.2 0.73 9.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 ESA07237.1 - 0.067 12.5 0.2 0.14 11.5 0.1 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.1 ESA07237.1 - 0.074 12.4 0.0 0.23 10.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain MMR_HSR1 PF01926.18 ESA07237.1 - 0.083 12.8 1.4 0.21 11.5 0.9 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zot PF05707.7 ESA07237.1 - 0.096 12.1 0.0 0.46 9.9 0.0 2.1 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) FtsK_SpoIIIE PF01580.13 ESA07237.1 - 0.1 12.0 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 ESA07237.1 - 0.13 12.2 0.6 0.38 10.6 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain DEAD PF00270.24 ESA07237.1 - 0.16 11.4 0.8 1.3 8.4 0.6 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase ABC_ATPase PF09818.4 ESA07237.1 - 0.18 10.3 2.8 0.35 9.3 0.2 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class ResIII PF04851.10 ESA07237.1 - 0.19 11.5 2.9 0.091 12.5 0.1 1.9 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESA07237.1 - 0.28 11.3 2.0 2.3 8.3 1.3 2.3 1 1 0 1 1 1 0 AAA domain TRAM_LAG1_CLN8 PF03798.11 ESA07238.1 - 1.2e-39 135.9 25.7 1.2e-39 135.9 17.8 1.7 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.6 ESA07238.1 - 3.5e-20 71.2 0.9 3.5e-20 71.2 0.6 2.7 2 0 0 2 2 2 1 TRAM1-like protein INSIG PF07281.7 ESA07239.1 - 6.1e-33 113.7 4.4 6.9e-33 113.6 3.1 1.0 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) DUF4401 PF14351.1 ESA07239.1 - 4.4e-05 22.6 0.5 4.4e-05 22.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4401) TLD PF07534.11 ESA07240.1 - 4.2e-11 43.0 0.1 4.8e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 TLD ORF6N PF10543.4 ESA07242.1 - 0.37 10.8 2.2 0.8 9.7 1.5 1.5 1 0 0 1 1 1 0 ORF6N domain Occludin_ELL PF07303.8 ESA07243.1 - 0.076 13.7 9.6 0.051 14.2 4.6 2.1 1 1 1 2 2 2 0 Occludin homology domain CCDC-167 PF15188.1 ESA07243.1 - 0.23 11.4 10.1 0.2 11.5 5.6 2.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 AAA_23 PF13476.1 ESA07243.1 - 0.62 10.3 7.6 0.84 9.9 5.3 1.3 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 ESA07243.1 - 1.9 8.0 9.1 4.3 6.8 6.2 1.5 1 1 0 1 1 1 0 IncA protein CDC37_N PF03234.9 ESA07243.1 - 2.1 8.6 15.2 0.63 10.3 6.7 2.1 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Hydrolase_like PF13242.1 ESA07244.1 - 3.2e-21 74.8 0.0 9.3e-21 73.3 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 ESA07244.1 - 1.3e-14 53.8 0.0 5.2e-14 51.9 0.0 1.9 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA07244.1 - 1.7e-05 25.0 0.0 8.3e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Pkinase PF00069.20 ESA07245.1 - 5.5e-19 68.3 0.3 6.8e-17 61.4 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07245.1 - 1.6e-17 63.4 0.1 1e-15 57.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA07245.1 - 0.033 13.9 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TMEM173 PF15009.1 ESA07245.1 - 0.098 11.4 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 173 DZR PF12773.2 ESA07245.1 - 0.13 12.1 2.0 0.23 11.2 1.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon Kelch_5 PF13854.1 ESA07247.1 - 0.00033 20.5 0.5 0.00073 19.4 0.3 1.7 1 1 0 1 1 1 1 Kelch motif Kelch_6 PF13964.1 ESA07247.1 - 0.0005 20.1 4.0 0.47 10.7 0.1 3.0 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA07247.1 - 0.00056 19.9 2.1 0.018 15.1 0.0 2.9 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA07247.1 - 0.0014 18.3 3.4 0.74 9.6 0.1 3.3 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA07247.1 - 0.0076 15.7 0.4 3.1 7.4 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Plant_all_beta PF10532.4 ESA07247.1 - 0.11 12.5 0.2 0.15 12.1 0.2 1.2 1 0 0 1 1 1 0 Plant specific N-all beta domain Pkinase_Tyr PF07714.12 ESA07248.1 - 3.3e-06 26.3 0.0 5.5e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DNA_repr_REX1B PF14966.1 ESA07248.1 - 0.065 13.6 0.3 0.62 10.4 0.0 2.2 2 1 0 2 2 2 0 DNA repair REX1-B Tet_JBP PF12851.2 ESA07249.1 - 8.1e-12 44.7 0.0 1.2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily 2OG-FeII_Oxy_3 PF13640.1 ESA07249.1 - 0.061 13.8 0.0 0.15 12.5 0.0 1.7 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily DUF718 PF05336.8 ESA07249.1 - 0.092 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF718) Desulfoferrod_N PF06397.7 ESA07250.1 - 0.15 11.4 0.7 0.25 10.7 0.5 1.3 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain BTB PF00651.26 ESA07253.1 - 8e-08 32.2 0.0 9.4e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain TP53IP5 PF15331.1 ESA07256.1 - 0.046 13.6 2.4 0.045 13.6 1.7 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Exo_endo_phos_2 PF14529.1 ESA07257.1 - 9.4e-11 41.3 4.4 9.4e-11 41.3 3.1 1.7 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA07257.1 - 5e-06 26.6 0.1 7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MADF_DNA_bdg PF10545.4 ESA07257.1 - 0.3 11.2 1.7 0.97 9.6 1.1 1.9 1 1 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Mmp37 PF09139.6 ESA07259.1 - 1.1e-113 379.6 1.3 1.1e-113 379.6 0.9 1.4 2 0 0 2 2 2 1 Mitochondrial matrix Mmp37 Lipase_3 PF01764.20 ESA07260.1 - 9.1e-19 67.4 0.0 2.1e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA07260.1 - 0.003 17.3 0.0 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA07260.1 - 0.14 12.0 0.9 0.37 10.6 0.6 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Arginase PF00491.16 ESA07261.1 - 4.5e-73 245.9 0.0 5e-73 245.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family Pkinase_Tyr PF07714.12 ESA07262.1 - 1e-38 132.8 0.0 3.2e-38 131.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07262.1 - 2.2e-36 125.3 0.0 1.4e-35 122.6 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA07262.1 - 0.00022 20.6 0.0 0.00049 19.4 0.0 1.5 1 0 0 1 1 1 1 RIO1 family EcKinase PF02958.15 ESA07262.1 - 0.014 14.5 0.1 1 8.4 0.0 2.3 2 0 0 2 2 2 0 Ecdysteroid kinase APH PF01636.18 ESA07262.1 - 0.023 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_1 PF00515.23 ESA07263.1 - 9.4e-08 31.3 5.0 0.0085 15.6 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07263.1 - 7.4e-07 28.7 3.7 1.8e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 ESA07263.1 - 1.4e-06 27.7 0.3 0.084 12.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA07263.1 - 0.0029 17.2 14.7 0.54 10.1 1.4 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA07263.1 - 0.0092 16.1 4.8 0.42 10.9 0.1 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA07263.1 - 0.026 14.6 5.8 0.17 12.0 0.1 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA07263.1 - 0.03 14.6 0.1 0.28 11.5 0.1 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat H_lectin PF09458.5 ESA07264.1 - 0.014 15.0 7.2 0.12 12.0 0.0 3.1 2 1 1 3 3 3 0 H-type lectin domain Exo_endo_phos_2 PF14529.1 ESA07265.1 - 2.2e-06 27.2 2.0 2.2e-06 27.2 1.4 2.3 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA07265.1 - 0.022 14.7 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family tRNA-synt_1 PF00133.17 ESA07266.1 - 1.2e-80 271.3 0.1 3.1e-60 203.8 0.0 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESA07266.1 - 2.6e-10 39.5 0.0 5.6e-10 38.4 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 ESA07266.1 - 3.9e-05 23.0 0.0 9.3e-05 21.7 0.0 1.5 1 1 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Uma2 PF05685.7 ESA07267.1 - 3.2e-20 72.1 0.0 3.9e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease XPC-binding PF09280.6 ESA07268.1 - 4.1e-24 83.8 11.2 6.2e-24 83.2 7.7 1.3 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.26 ESA07268.1 - 1.7e-07 30.8 5.9 7.2e-07 28.8 1.3 3.1 3 0 0 3 3 3 1 UBA/TS-N domain DUF2999 PF11212.3 ESA07268.1 - 0.15 12.0 0.7 0.36 10.8 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2999) DUF3135 PF11333.3 ESA07268.1 - 0.21 11.7 2.7 1.7 8.8 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3135) Pkinase PF00069.20 ESA07269.1 - 2.8e-57 193.8 0.0 3.3e-57 193.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07269.1 - 4.3e-39 134.1 0.0 5.7e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA07269.1 - 8.4e-06 24.9 0.0 1.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DUF3121 PF11319.3 ESA07270.1 - 0.017 14.6 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3121) HMG_box PF00505.14 ESA07271.1 - 8.1e-05 22.8 1.0 0.00011 22.3 0.0 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07271.1 - 0.00095 19.4 0.8 0.0021 18.3 0.2 1.8 1 1 1 2 2 2 1 HMG-box domain DDHD PF02862.12 ESA07272.1 - 1.9e-54 184.8 0.0 2.5e-54 184.4 0.0 1.1 1 0 0 1 1 1 1 DDHD domain BSMAP PF12280.3 ESA07272.1 - 0.0096 15.8 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 Brain specific membrane anchored protein p450 PF00067.17 ESA07273.1 - 1.1e-52 179.1 0.1 1.2e-52 179.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kunitz_legume PF00197.13 ESA07276.1 - 0.014 14.9 0.6 0.014 14.9 0.4 1.1 1 0 0 1 1 1 0 Trypsin and protease inhibitor DUF1033 PF06279.6 ESA07276.1 - 0.037 13.8 1.1 0.043 13.6 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) DUF1741 PF08427.5 ESA07277.1 - 6.8e-41 140.2 0.1 7.8e-41 140.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Kinesin PF00225.18 ESA07278.1 - 0.00013 20.7 1.0 0.00021 20.1 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Macoilin PF09726.4 ESA07278.1 - 0.025 12.8 8.4 0.012 13.9 4.5 1.2 1 1 0 1 1 1 0 Transmembrane protein DnaI_N PF07319.6 ESA07278.1 - 0.033 14.4 1.2 1.2 9.4 0.0 2.8 2 1 0 2 2 2 0 Primosomal protein DnaI N-terminus FKBP_N PF01346.13 ESA07278.1 - 0.038 14.0 0.5 0.038 14.0 0.4 2.6 2 1 1 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase OmpH PF03938.9 ESA07278.1 - 0.24 11.3 5.7 1.8 8.4 1.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4559 PF15112.1 ESA07278.1 - 0.45 9.6 5.2 4.4 6.3 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) ATG16 PF08614.6 ESA07278.1 - 0.9 9.3 10.6 0.033 14.0 2.6 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) FadA PF09403.5 ESA07278.1 - 1.6 8.7 9.6 0.24 11.4 0.3 2.7 2 1 0 2 2 2 0 Adhesion protein FadA Abhydrolase_3 PF07859.8 ESA07279.1 - 9.3e-40 136.4 0.2 6.2e-39 133.7 0.0 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA07279.1 - 1.8e-13 49.9 0.0 6.3e-13 48.1 0.0 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA07279.1 - 4.2e-06 26.5 0.1 6.5e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 ESA07279.1 - 9.8e-05 21.2 1.1 0.26 9.9 0.0 2.5 3 0 0 3 3 3 2 Carboxylesterase family Abhydrolase_2 PF02230.11 ESA07279.1 - 0.086 12.2 0.0 0.22 10.9 0.0 1.7 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Macoilin PF09726.4 ESA07280.1 - 6 5.0 8.8 7.5 4.7 6.1 1.1 1 0 0 1 1 1 0 Transmembrane protein RasGEF PF00617.14 ESA07281.1 - 2.4e-16 60.0 2.9 4.8e-16 59.0 2.0 1.5 1 0 0 1 1 1 1 RasGEF domain PAM2 PF07145.10 ESA07281.1 - 4.3e-05 22.7 0.6 0.00011 21.4 0.4 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region CUE PF02845.11 ESA07282.1 - 1.6e-10 40.2 0.0 3.1e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 CUE domain Atg14 PF10186.4 ESA07282.1 - 2.9 6.7 10.4 4.3 6.2 7.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ATP-synt_E PF05680.7 ESA07282.1 - 7.3 6.6 7.8 11 6.1 4.6 1.9 2 0 0 2 2 2 0 ATP synthase E chain PRANC PF09372.5 ESA07285.1 - 0.12 12.3 5.2 0.14 12.1 3.6 1.1 1 0 0 1 1 1 0 PRANC domain vATP-synt_E PF01991.13 ESA07285.1 - 0.13 11.5 1.2 0.15 11.3 0.9 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Borrelia_lipo_2 PF06238.6 ESA07285.1 - 0.98 9.4 5.2 3.8 7.6 1.2 2.1 1 1 1 2 2 2 0 Borrelia burgdorferi BBR25 lipoprotein Asp-B-Hydro_N PF05279.6 ESA07286.1 - 0.4 10.5 3.3 0.46 10.2 2.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SRP72 PF08492.7 ESA07286.1 - 3 8.2 6.0 11 6.4 1.6 2.4 1 1 1 2 2 2 0 SRP72 RNA-binding domain SRP-alpha_N PF04086.8 ESA07286.1 - 3.7 6.8 9.0 4.6 6.5 6.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal NDUFA12 PF05071.11 ESA07287.1 - 1.2 9.6 5.4 0.55 10.7 0.5 2.2 2 0 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF3671 PF12420.3 ESA07288.1 - 0.23 11.4 2.0 0.22 11.5 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function Peptidase_S41 PF03572.13 ESA07289.1 - 2.4e-06 27.0 0.0 4.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 Phage_capsid PF05065.8 ESA07291.1 - 0.011 14.9 0.1 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Phage capsid family Imm32 PF15579.1 ESA07291.1 - 0.094 12.2 0.1 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Immunity protein 32 Inhibitor_I24 PF10465.4 ESA07291.1 - 0.14 11.8 1.5 0.19 11.4 1.1 1.3 1 1 0 1 1 1 0 PinA peptidase inhibitor ALG3 PF05208.8 ESA07292.1 - 0.034 13.3 0.2 0.034 13.3 0.1 1.0 1 0 0 1 1 1 0 ALG3 protein CobU PF02283.11 ESA07294.1 - 0.14 11.5 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase zf-RING_2 PF13639.1 ESA07296.1 - 0.032 14.0 3.7 0.052 13.3 2.5 1.5 1 1 0 1 1 1 0 Ring finger domain BACK PF07707.10 ESA07297.1 - 5.3e-06 26.2 0.3 3.8e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Dimer_Tnp_hAT PF05699.9 ESA07298.1 - 1.8e-11 43.4 0.0 1.9e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Mgm101p PF06420.7 ESA07301.1 - 4e-89 296.4 0.0 5.3e-89 296.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 IBR PF01485.16 ESA07302.1 - 1.2e-16 60.3 31.0 1.4e-08 34.4 1.3 4.1 3 1 1 4 4 4 3 IBR domain zf-RING_2 PF13639.1 ESA07302.1 - 0.0028 17.4 6.1 0.0028 17.4 4.2 3.4 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA07302.1 - 0.0066 16.4 8.1 0.0066 16.4 5.6 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.13 ESA07302.1 - 0.1 12.9 0.5 0.1 12.9 0.3 4.3 3 1 1 4 4 4 0 TRAF-type zinc finger STN1_2 PF09170.5 ESA07303.1 - 0.084 12.6 0.8 0.12 12.0 0.6 1.2 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Sex_peptide PF08138.6 ESA07303.1 - 0.21 11.4 1.4 0.57 10.0 0.0 2.3 2 0 0 2 2 2 0 Sex peptide (SP) family CBM49 PF09478.5 ESA07303.1 - 2.6 8.1 6.5 2.4 8.3 0.1 2.4 2 1 0 2 2 2 0 Carbohydrate binding domain CBM49 Striatin PF08232.7 ESA07306.1 - 0.013 15.8 9.6 0.027 14.7 6.7 1.5 1 0 0 1 1 1 0 Striatin family Imm46 PF15585.1 ESA07306.1 - 0.019 14.9 0.7 1.2 9.2 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 46 ELFV_dehydrog PF00208.16 ESA07306.1 - 0.033 13.7 4.0 0.042 13.4 0.5 2.2 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TSC22 PF01166.13 ESA07306.1 - 0.073 13.0 3.5 1.9 8.5 0.2 2.9 1 1 1 2 2 2 0 TSC-22/dip/bun family HALZ PF02183.13 ESA07306.1 - 0.33 10.6 6.5 4 7.2 1.0 2.7 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 ESA07306.1 - 0.58 10.5 14.4 15 5.9 8.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Microtub_assoc PF07989.6 ESA07306.1 - 0.66 9.8 8.2 0.23 11.2 0.4 2.7 2 1 1 3 3 3 0 Microtubule associated bZIP_1 PF00170.16 ESA07306.1 - 1.3 9.0 11.6 0.29 11.1 0.3 3.2 2 1 1 3 3 3 0 bZIP transcription factor DivIC PF04977.10 ESA07306.1 - 8 6.0 13.8 0.16 11.4 1.4 3.0 2 1 1 3 3 3 0 Septum formation initiator IFN-gamma PF00714.12 ESA07308.1 - 0.083 12.7 0.9 0.18 11.6 0.6 1.5 1 0 0 1 1 1 0 Interferon gamma Imm13 PF15564.1 ESA07309.1 - 0.0025 17.5 2.2 0.059 13.0 0.1 2.9 1 1 2 3 3 3 1 Immunity protein 13 DUF1127 PF06568.6 ESA07309.1 - 0.026 13.9 0.6 0.039 13.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) DUF3417 PF11897.3 ESA07309.1 - 0.058 13.3 3.2 2.9 7.8 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3417) DNA_topoisoIV PF00521.15 ESA07309.1 - 0.14 10.9 7.0 0.23 10.2 4.9 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DUF1904 PF08921.6 ESA07309.1 - 0.16 12.0 2.0 0.38 10.8 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1904) DUF4038 PF13204.1 ESA07309.1 - 0.34 10.1 3.2 0.51 9.6 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) Telomere_Sde2 PF13019.1 ESA07310.1 - 9.3e-40 135.9 0.1 9.3e-40 135.9 0.1 1.8 2 0 0 2 2 2 1 Telomere stability and silencing GTSE1_N PF15259.1 ESA07310.1 - 0.0019 18.1 2.7 0.0019 18.1 1.9 2.3 2 0 0 2 2 2 1 G-2 and S-phase expressed 1 SID-1_RNA_chan PF13965.1 ESA07310.1 - 0.13 10.3 0.1 0.13 10.3 0.1 1.9 2 1 1 3 3 3 0 dsRNA-gated channel SID-1 DUF2407 PF10302.4 ESA07310.1 - 7.8 6.7 13.8 1.5e+04 -3.8 9.6 3.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Glyco_trans_1_3 PF13528.1 ESA07311.1 - 0.045 12.9 0.1 0.3 10.2 0.0 2.0 1 1 1 2 2 2 0 Glycosyl transferase family 1 EF-hand_4 PF12763.2 ESA07312.1 - 0.057 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DEAD PF00270.24 ESA07313.1 - 3.1e-37 127.6 0.1 7.8e-37 126.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA07313.1 - 4.5e-24 84.1 0.0 9.7e-24 83.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA07313.1 - 0.00013 21.8 0.0 0.00029 20.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 ESA07313.1 - 0.0005 19.2 0.0 0.0015 17.6 0.0 1.8 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit PARP PF00644.15 ESA07314.1 - 1.2e-68 230.6 0.0 1.2e-68 230.6 0.0 2.6 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 ESA07314.1 - 1.1e-42 144.8 0.4 3.3e-42 143.3 0.3 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 ESA07314.1 - 9.8e-20 70.3 0.7 3.3e-19 68.6 0.5 1.9 1 0 0 1 1 1 1 WGR domain BRCT PF00533.21 ESA07314.1 - 8.5e-13 48.2 0.3 2.4e-12 46.8 0.2 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESA07314.1 - 0.00039 20.2 0.3 0.00076 19.2 0.2 1.6 1 0 0 1 1 1 1 twin BRCT domain Flp_Fap PF04964.9 ESA07315.1 - 0.14 11.8 1.4 0.83 9.3 0.2 2.2 2 0 0 2 2 2 0 Flp/Fap pilin component SET PF00856.23 ESA07316.1 - 3.5e-09 37.1 0.3 9.7e-09 35.7 0.1 1.7 2 0 0 2 2 2 1 SET domain TPR_12 PF13424.1 ESA07316.1 - 0.00025 20.9 0.0 0.0016 18.3 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA07316.1 - 0.015 14.4 0.1 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat KbaA PF14089.1 ESA07316.1 - 0.015 14.8 0.1 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 KinB-signalling pathway activation in sporulation TPR_2 PF07719.12 ESA07316.1 - 0.025 14.4 0.4 1.3 9.1 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA07316.1 - 0.027 14.7 0.2 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA07316.1 - 0.79 9.6 5.5 1.5 8.7 0.4 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat SAM_1 PF00536.25 ESA07319.1 - 0.00016 21.8 0.1 0.00032 20.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ribosomal_S11 PF00411.14 ESA07320.1 - 5.7e-16 58.6 3.6 7e-12 45.4 0.5 2.5 1 1 1 2 2 2 2 Ribosomal protein S11 FAM220 PF15487.1 ESA07320.1 - 0.0089 15.4 5.2 0.012 15.0 3.6 1.1 1 0 0 1 1 1 1 FAM220 family Macoilin PF09726.4 ESA07320.1 - 1.5 7.0 9.7 1.7 6.8 6.7 1.1 1 0 0 1 1 1 0 Transmembrane protein SR-25 PF10500.4 ESA07320.1 - 9.6 5.5 13.7 17 4.7 9.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.5 ESA07321.1 - 0.16 10.3 3.4 0.18 10.2 2.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PXA PF02194.10 ESA07323.1 - 0.0046 16.5 1.7 0.0062 16.1 1.2 1.2 1 0 0 1 1 1 1 PXA domain Serine_rich PF08824.5 ESA07323.1 - 0.0056 16.4 1.5 0.02 14.6 0.1 2.0 1 1 1 2 2 2 1 Serine rich protein interaction domain Adeno_52K PF03052.10 ESA07323.1 - 0.03 13.5 0.6 0.05 12.8 0.4 1.3 1 0 0 1 1 1 0 Adenoviral protein L1 52/55-kDa Scaffolding_pro PF11418.3 ESA07323.1 - 0.034 14.4 7.8 1.4 9.2 0.8 2.4 1 1 1 2 2 2 0 Phi29 scaffolding protein DUF643 PF04867.7 ESA07323.1 - 0.12 12.8 8.8 0.15 12.4 2.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF643) DUF948 PF06103.6 ESA07323.1 - 0.12 12.1 0.5 0.27 11.1 0.3 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Baculo_LEF-10 PF07206.6 ESA07323.1 - 0.39 10.3 2.2 1.1 8.9 0.7 2.3 2 1 1 3 3 3 0 Baculovirus late expression factor 10 (LEF-10) PRP1_N PF06424.7 ESA07323.1 - 1.8 8.9 5.5 1.4 9.2 0.1 2.7 2 1 0 3 3 3 0 PRP1 splicing factor, N-terminal DivIC PF04977.10 ESA07323.1 - 7.4 6.1 9.3 2.5 7.6 0.1 3.1 1 1 2 3 3 3 0 Septum formation initiator DivIVA PF05103.8 ESA07324.1 - 0.0012 18.9 3.3 0.0015 18.5 2.3 1.1 1 0 0 1 1 1 1 DivIVA protein FlxA PF14282.1 ESA07324.1 - 0.0017 18.2 15.8 0.016 15.1 6.6 2.1 2 0 0 2 2 2 1 FlxA-like protein Prominin PF05478.6 ESA07324.1 - 0.0019 15.8 3.2 0.0022 15.6 2.2 1.1 1 0 0 1 1 1 1 Prominin AATF-Che1 PF13339.1 ESA07324.1 - 0.0051 16.9 1.4 0.0058 16.7 1.0 1.1 1 0 0 1 1 1 1 Apoptosis antagonizing transcription factor Dzip-like_N PF13815.1 ESA07324.1 - 0.0083 15.9 0.8 0.0083 15.9 0.6 1.5 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF3573 PF12097.3 ESA07324.1 - 0.0085 14.7 4.3 0.0097 14.5 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3573) IncA PF04156.9 ESA07324.1 - 0.0095 15.5 8.9 0.013 15.0 6.2 1.2 1 0 0 1 1 1 1 IncA protein BLOC1_2 PF10046.4 ESA07324.1 - 0.014 15.5 2.8 0.059 13.5 0.5 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.8 ESA07324.1 - 0.014 14.4 2.5 0.016 14.3 1.7 1.0 1 0 0 1 1 1 0 TMPIT-like protein Tropomyosin PF00261.15 ESA07324.1 - 0.021 13.9 5.1 0.11 11.6 2.6 2.0 2 0 0 2 2 2 0 Tropomyosin TMF_DNA_bd PF12329.3 ESA07324.1 - 0.026 14.3 19.1 0.34 10.7 13.2 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Activator_LAG-3 PF11498.3 ESA07324.1 - 0.031 13.0 2.9 0.031 13.0 2.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Fib_alpha PF08702.5 ESA07324.1 - 0.031 14.3 2.9 0.11 12.6 0.8 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family IF-2B PF01008.12 ESA07324.1 - 0.033 13.1 0.2 0.035 13.1 0.2 1.1 1 0 0 1 1 1 0 Initiation factor 2 subunit family Jnk-SapK_ap_N PF09744.4 ESA07324.1 - 0.039 13.9 5.1 0.047 13.6 2.2 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Spectrin PF00435.16 ESA07324.1 - 0.052 13.8 2.8 0.26 11.6 0.9 2.0 2 0 0 2 2 2 0 Spectrin repeat DUF4407 PF14362.1 ESA07324.1 - 0.058 12.3 1.8 0.063 12.2 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YopH_N PF09013.5 ESA07324.1 - 0.06 13.0 1.4 0.072 12.7 0.9 1.1 1 0 0 1 1 1 0 YopH, N-terminal DUF496 PF04363.7 ESA07324.1 - 0.068 12.9 2.9 0.073 12.8 1.2 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF496) Atg14 PF10186.4 ESA07324.1 - 0.068 12.1 3.7 0.083 11.8 2.6 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 eIF-4B PF06273.6 ESA07324.1 - 0.071 11.8 1.1 0.081 11.6 0.8 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B V_ATPase_I PF01496.14 ESA07324.1 - 0.11 10.3 1.2 0.11 10.3 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NAP PF00956.13 ESA07324.1 - 0.11 11.5 1.8 0.12 11.4 1.3 1.2 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) ERp29 PF07749.7 ESA07324.1 - 0.11 13.0 4.0 0.18 12.4 2.8 1.4 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Prefoldin_2 PF01920.15 ESA07324.1 - 0.12 12.2 8.7 0.53 10.0 3.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit WXG100 PF06013.7 ESA07324.1 - 0.12 12.3 2.6 4.9 7.2 0.3 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG GP41 PF00517.12 ESA07324.1 - 0.19 11.2 7.8 0.15 11.6 3.8 1.7 2 0 0 2 2 2 0 Retroviral envelope protein DUF724 PF05266.9 ESA07324.1 - 0.2 11.2 3.7 0.26 10.9 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3186 PF11382.3 ESA07324.1 - 0.22 10.6 4.4 0.3 10.1 3.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3186) GBP_C PF02841.9 ESA07324.1 - 0.22 10.6 6.8 0.26 10.4 4.7 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain COG5 PF10392.4 ESA07324.1 - 0.23 11.3 5.5 2.6 7.9 1.3 2.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Tropomyosin_1 PF12718.2 ESA07324.1 - 0.26 11.1 11.5 0.98 9.2 8.0 1.7 1 1 0 1 1 1 0 Tropomyosin like FliD_C PF07195.7 ESA07324.1 - 0.27 10.5 6.5 0.099 11.9 2.6 1.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus DivIC PF04977.10 ESA07324.1 - 0.31 10.5 14.7 2.3 7.7 6.9 2.5 1 1 1 2 2 2 0 Septum formation initiator DUF4200 PF13863.1 ESA07324.1 - 0.37 10.7 8.4 1.3 8.9 3.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) ATG16 PF08614.6 ESA07324.1 - 0.37 10.5 10.3 0.083 12.7 4.6 1.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SseC PF04888.7 ESA07324.1 - 0.45 9.7 6.6 0.2 10.9 2.5 1.7 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Nup54 PF13874.1 ESA07324.1 - 0.49 10.0 6.8 0.64 9.6 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Laminin_II PF06009.7 ESA07324.1 - 0.57 9.9 7.3 1.8 8.3 5.0 1.7 1 1 0 1 1 1 0 Laminin Domain II Med11 PF10280.4 ESA07324.1 - 0.8 9.7 6.4 12 6.0 4.3 2.2 1 1 1 2 2 2 0 Mediator complex protein MbeD_MobD PF04899.7 ESA07324.1 - 1.4 8.8 5.5 1.1 9.1 1.2 2.2 2 1 0 2 2 2 0 MbeD/MobD like RasGAP_C PF03836.10 ESA07324.1 - 1.5 8.5 11.2 1.4 8.6 4.4 2.1 1 1 1 2 2 2 0 RasGAP C-terminus LRS4 PF10422.4 ESA07324.1 - 2.1 7.6 10.7 2.6 7.3 7.4 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF2680 PF10925.3 ESA07324.1 - 2.2 8.2 7.3 3.1 7.7 1.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2680) FemAB PF02388.11 ESA07324.1 - 2.7 6.5 6.1 1.8 7.1 3.5 1.3 1 1 0 1 1 1 0 FemAB family Ax_dynein_light PF10211.4 ESA07324.1 - 3.5 7.4 9.8 10 5.8 6.6 1.8 1 1 0 1 1 1 0 Axonemal dynein light chain DUF3735 PF12537.3 ESA07324.1 - 4.9 7.2 7.1 59 3.8 2.9 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3735) bZIP_1 PF00170.16 ESA07324.1 - 6.6 6.7 9.8 2.5 8.1 4.2 2.0 2 0 0 2 2 2 0 bZIP transcription factor AKNA PF12443.3 ESA07324.1 - 8.7 6.4 9.6 28 4.7 3.3 2.3 1 1 1 2 2 2 0 AT-hook-containing transcription factor CtIP_N PF10482.4 ESA07325.1 - 0.0085 15.8 1.6 0.015 15.0 1.1 1.4 1 0 0 1 1 1 1 Tumour-suppressor protein CtIP N-terminal domain CENP-F_leu_zip PF10473.4 ESA07325.1 - 0.019 14.8 13.2 0.078 12.8 0.9 3.0 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_C6 PF00851.13 ESA07325.1 - 0.13 10.8 5.1 0.18 10.3 3.5 1.1 1 0 0 1 1 1 0 Helper component proteinase IFP_35_N PF07334.8 ESA07325.1 - 2.4 8.2 7.7 0.22 11.5 0.9 2.4 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Cep57_CLD_2 PF14197.1 ESA07325.1 - 5.2 7.0 10.2 7.5 6.5 2.5 2.8 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 ParB PF08775.5 ESA07325.1 - 5.8 7.2 8.4 1.9 8.8 2.6 2.3 2 1 1 3 3 3 0 ParB family YqfD PF06898.6 ESA07326.1 - 0.012 14.3 0.3 0.012 14.3 0.2 1.4 1 1 0 1 1 1 0 Putative stage IV sporulation protein YqfD Zn_clus PF00172.13 ESA07328.1 - 3.8e-06 26.7 13.1 8.3e-06 25.6 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_C34 PF05413.6 ESA07330.1 - 0.0042 17.1 2.1 0.29 11.1 0.0 3.0 2 1 1 3 3 3 2 Putative closterovirus papain-like endopeptidase Bt_P21 PF05560.6 ESA07332.1 - 0.058 12.7 0.2 0.093 12.1 0.1 1.3 1 1 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein DUF1542 PF07564.6 ESA07332.1 - 0.26 11.3 0.3 0.26 11.3 0.2 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) CAML PF14963.1 ESA07338.1 - 0.022 14.1 1.9 0.025 13.9 0.4 1.9 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF4208 PF13907.1 ESA07338.1 - 0.059 13.5 0.6 0.059 13.5 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) DUF3221 PF11518.3 ESA07338.1 - 3.6 7.3 10.6 2.3 7.8 2.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3221) MNNL PF07657.8 ESA07339.1 - 0.11 12.4 1.4 0.12 12.2 0.9 1.1 1 0 0 1 1 1 0 N terminus of Notch ligand TehB PF03848.9 ESA07340.1 - 0.095 11.8 0.1 0.095 11.8 0.0 1.0 1 0 0 1 1 1 0 Tellurite resistance protein TehB LRR_8 PF13855.1 ESA07341.1 - 0.19 11.4 7.9 1.9 8.3 0.5 3.4 2 1 1 3 3 3 0 Leucine rich repeat DUF2410 PF10307.4 ESA07341.1 - 0.22 10.8 3.6 0.26 10.6 0.9 1.9 1 1 1 2 2 2 0 Hypothetical protein (DUF2410) LRR_4 PF12799.2 ESA07341.1 - 0.65 9.6 10.5 2.9 7.5 0.7 3.4 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) Pkinase PF00069.20 ESA07343.1 - 1.6e-43 148.7 0.1 2e-43 148.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07343.1 - 3.3e-40 137.7 0.0 4.2e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA07343.1 - 2.9e-05 23.2 0.0 7.7e-05 21.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA07343.1 - 0.0044 16.3 0.2 0.0074 15.6 0.2 1.4 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA07343.1 - 0.0058 16.3 0.1 0.032 13.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA07343.1 - 0.016 14.2 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA07343.1 - 0.025 13.9 0.1 0.04 13.2 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.12 ESA07344.1 - 5.1e-38 130.6 0.0 6e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07344.1 - 1.4e-32 112.9 0.0 1.8e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07344.1 - 0.022 13.8 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Na_H_Exchanger PF00999.16 ESA07345.1 - 4.9e-64 216.2 40.7 7.2e-64 215.6 28.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family XRCC4 PF06632.7 ESA07346.1 - 0.092 11.5 3.3 0.1 11.4 2.3 1.0 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF1168 PF06658.7 ESA07346.1 - 0.15 11.5 7.8 0.16 11.4 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DUF702 PF05142.7 ESA07346.1 - 0.39 10.8 5.1 0.41 10.8 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF702) PH_5 PF15405.1 ESA07346.1 - 0.59 10.0 5.1 0.76 9.7 3.5 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain Menin PF05053.8 ESA07346.1 - 0.89 7.6 7.1 0.87 7.6 4.9 1.1 1 0 0 1 1 1 0 Menin SID-1_RNA_chan PF13965.1 ESA07346.1 - 1.6 6.7 5.5 1.8 6.6 3.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Pex14_N PF04695.8 ESA07346.1 - 2.1 8.3 12.5 2.6 8.0 8.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3035 PF11233.3 ESA07346.1 - 3 7.8 7.9 3 7.8 5.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3035) ETRAMP PF09716.5 ESA07346.1 - 5 7.1 5.2 6 6.8 3.6 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Ctr PF04145.10 ESA07346.1 - 8.1 6.4 6.0 9.7 6.2 4.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family CRAL_TRIO PF00650.15 ESA07347.1 - 2e-37 128.1 0.0 2.9e-37 127.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 ESA07347.1 - 1.2e-08 34.9 0.0 2.1e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESA07347.1 - 1.4e-06 28.3 1.5 3.1e-06 27.2 1.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF2689 PF10894.3 ESA07347.1 - 0.029 14.1 0.0 0.092 12.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) DUF3579 PF12112.3 ESA07347.1 - 0.03 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3579) Pkinase PF00069.20 ESA07348.1 - 4.8e-67 225.8 0.0 8.1e-67 225.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07348.1 - 3.3e-33 114.8 0.0 5.2e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA07348.1 - 0.0075 16.0 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA07348.1 - 0.015 14.3 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like OSTMP1 PF09777.4 ESA07349.1 - 0.034 13.3 0.4 0.04 13.1 0.2 1.1 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Cytochrome_cB PF11783.3 ESA07349.1 - 0.037 13.5 0.1 0.049 13.1 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c bacterial DUF1180 PF06679.7 ESA07350.1 - 0.042 13.7 4.6 0.045 13.6 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4487 PF14868.1 ESA07351.1 - 0.0001 21.1 0.1 0.0002 20.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4487) AbiH PF14253.1 ESA07352.1 - 0.04 13.5 0.1 0.044 13.3 0.1 1.0 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH PPK2 PF03976.9 ESA07352.1 - 0.078 12.2 0.1 0.093 12.0 0.1 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) Cytidylate_kin PF02224.13 ESA07353.1 - 6.5e-46 155.6 3.0 1.3e-33 115.6 1.0 2.2 2 0 0 2 2 2 2 Cytidylate kinase AAA_17 PF13207.1 ESA07353.1 - 2.8e-09 37.8 0.0 6.4e-08 33.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA07353.1 - 0.0018 18.5 0.0 0.047 14.0 0.0 2.6 1 1 1 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.1 ESA07353.1 - 0.0092 15.9 0.5 0.67 9.8 0.4 2.3 1 1 0 1 1 1 1 Cytidylate kinase-like family RGCC PF15151.1 ESA07353.1 - 0.019 15.3 0.1 0.038 14.4 0.1 1.4 1 0 0 1 1 1 0 Response gene to complement 32 protein family SKI PF01202.17 ESA07353.1 - 0.025 14.4 0.6 0.095 12.5 0.0 2.0 2 0 0 2 2 2 0 Shikimate kinase KH_1 PF00013.24 ESA07354.1 - 8.3e-05 22.1 0.3 0.00052 19.6 0.0 2.2 1 1 1 2 2 2 1 KH domain KH_3 PF13014.1 ESA07354.1 - 0.00062 19.3 0.4 0.0016 18.0 0.0 2.0 2 0 0 2 2 2 1 KH domain KH_4 PF13083.1 ESA07354.1 - 0.0053 16.3 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 KH domain UQ_con PF00179.21 ESA07355.1 - 9.4e-08 31.5 0.0 1.6e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA07355.1 - 0.00048 20.0 0.0 0.00069 19.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 ESA07355.1 - 0.0065 16.2 0.0 0.0098 15.6 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B adh_short PF00106.20 ESA07356.1 - 1.9e-22 79.9 0.0 3e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA07356.1 - 7.8e-17 61.8 0.2 1e-16 61.4 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 ESA07356.1 - 0.00024 20.6 0.1 0.00094 18.6 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 ESA07356.1 - 0.00051 19.7 0.2 0.00099 18.8 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.5 ESA07356.1 - 0.00079 19.1 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Methyltransf_31 PF13847.1 ESA07356.1 - 0.015 14.8 0.1 0.027 14.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain DFP PF04127.10 ESA07356.1 - 0.037 13.6 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein YjeF_N PF03853.10 ESA07356.1 - 0.1 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus HSP70 PF00012.15 ESA07358.1 - 2.8e-239 795.0 4.8 3.2e-239 794.8 3.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA07358.1 - 2.3e-13 49.4 0.4 6.2e-12 44.7 0.0 2.4 3 0 0 3 3 3 2 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA07358.1 - 0.0011 18.1 0.7 0.0041 16.2 0.0 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Thr_dehydrat_C PF00585.13 ESA07359.1 - 0.034 13.7 0.1 0.069 12.7 0.0 1.5 2 0 0 2 2 2 0 C-terminal regulatory domain of Threonine dehydratase Autophagy_act_C PF03987.10 ESA07360.1 - 4e-10 39.7 5.2 2e-09 37.5 1.8 2.8 2 1 0 2 2 2 1 Autophagocytosis associated protein, active-site domain UCH PF00443.24 ESA07361.1 - 3.7e-61 206.5 3.2 3.7e-61 206.5 2.2 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA07361.1 - 6.7e-28 97.9 0.6 6.7e-28 97.9 0.4 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 ESA07361.1 - 4.7e-09 36.5 2.5 0.0067 16.8 0.1 4.1 3 1 0 3 3 3 2 DUSP domain zf-UBP PF02148.14 ESA07361.1 - 2.6e-08 33.8 9.7 2.6e-08 33.8 6.7 2.1 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein CP2 PF04516.10 ESA07362.1 - 5.3e-60 202.4 0.2 8.8e-60 201.6 0.1 1.3 1 0 0 1 1 1 1 CP2 transcription factor Pkinase_Tyr PF07714.12 ESA07364.1 - 2.3e-08 33.4 0.1 3.8e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07364.1 - 7.2e-05 22.0 0.6 0.0014 17.8 0.0 2.6 2 1 1 3 3 3 1 Protein kinase domain Sterile PF03015.14 ESA07364.1 - 0.24 11.6 1.6 0.39 11.0 0.7 1.6 1 1 0 1 1 1 0 Male sterility protein TPR_11 PF13414.1 ESA07365.1 - 3.3e-14 52.2 0.1 4.2e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 ESA07365.1 - 2.2e-06 27.0 0.0 0.036 13.6 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA07365.1 - 1.5e-05 24.5 0.1 0.21 11.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA07365.1 - 0.0002 21.9 0.1 0.00041 20.9 0.0 1.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA07365.1 - 0.00023 21.5 0.0 0.1 13.2 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA07365.1 - 0.0004 20.3 0.0 0.004 17.2 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA07365.1 - 0.00048 20.4 0.0 0.00077 19.7 0.0 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA07365.1 - 0.0025 17.6 0.0 0.0035 17.1 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA07365.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat SET PF00856.23 ESA07366.1 - 2.7e-07 31.0 0.1 5.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 SET domain TPR_19 PF14559.1 ESA07366.1 - 0.00026 21.2 0.0 0.024 14.9 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF3885 PF13021.1 ESA07368.1 - 0.1 12.3 3.7 0.13 11.9 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3885) Response_reg PF00072.19 ESA07369.1 - 8.8e-15 54.6 0.1 1.3e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain BTB PF00651.26 ESA07370.1 - 2.7e-13 49.8 0.2 2.8e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 BTB/POZ domain BACK PF07707.10 ESA07370.1 - 0.0034 17.1 0.1 0.27 11.0 0.0 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch Cu-oxidase_3 PF07732.10 ESA07371.1 - 4.1e-43 145.8 5.6 1.3e-41 141.0 0.2 3.9 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.17 ESA07371.1 - 1.3e-40 138.8 0.1 8.4e-39 133.0 0.0 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA07371.1 - 1e-38 131.9 3.4 1.8e-34 118.2 0.7 3.9 4 0 0 4 4 4 2 Multicopper oxidase Myb_DNA-bind_4 PF13837.1 ESA07373.1 - 1.1e-11 44.6 10.4 1.5e-05 25.0 1.4 2.2 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA07373.1 - 0.025 14.7 5.3 0.97 9.6 0.4 2.6 2 2 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_3 PF12776.2 ESA07373.1 - 0.029 14.9 5.4 0.66 10.6 0.7 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain MACPF PF01823.14 ESA07375.1 - 1.2e-05 25.1 2.2 2.7e-05 23.9 1.6 1.6 1 1 0 1 1 1 1 MAC/Perforin domain SNAP PF14938.1 ESA07375.1 - 0.022 13.8 0.0 0.04 13.0 0.0 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Gly_radical PF01228.16 ESA07375.1 - 0.06 13.7 0.7 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 Glycine radical Lipocalin_6 PF13944.1 ESA07375.1 - 0.47 10.5 3.1 0.48 10.5 0.2 2.5 3 1 0 3 3 3 0 Lipocalin-like domain Mob1_phocein PF03637.12 ESA07376.1 - 0.004 16.8 1.0 0.0064 16.1 0.7 1.3 1 0 0 1 1 1 1 Mob1/phocein family FANCI_S3 PF14677.1 ESA07377.1 - 0.017 14.5 1.4 0.094 12.0 0.7 1.9 2 0 0 2 2 2 0 FANCI solenoid 3 PurS PF02700.9 ESA07377.1 - 0.052 13.5 0.7 0.12 12.3 0.2 1.8 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase Maelstrom PF13017.1 ESA07378.1 - 0.0056 16.1 3.4 0.56 9.6 0.4 2.0 2 0 0 2 2 2 2 piRNA pathway germ-plasm component Phasin PF05597.6 ESA07378.1 - 3.4 7.4 10.3 1.8 8.3 3.0 2.3 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CDC37_N PF03234.9 ESA07378.1 - 3.4 7.9 12.0 1.1 9.4 2.5 2.1 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Ricin_B_lectin PF00652.17 ESA07379.1 - 4.3e-07 29.9 0.1 0.0065 16.5 0.0 2.3 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain C2 PF00168.25 ESA07379.1 - 5.8e-07 29.2 0.1 7.4e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 C2 domain DUF3221 PF11518.3 ESA07379.1 - 0.021 14.4 0.2 0.48 10.0 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3221) RicinB_lectin_2 PF14200.1 ESA07379.1 - 0.028 14.7 0.2 0.14 12.5 0.2 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Vac_Fusion PF02346.11 ESA07380.1 - 0.0062 15.9 0.2 0.0087 15.4 0.1 1.4 1 0 0 1 1 1 1 Chordopoxvirus fusion protein Semialdhyde_dhC PF02774.13 ESA07381.1 - 2.9e-44 151.1 0.0 4.2e-44 150.6 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 ESA07381.1 - 1.9e-30 105.6 0.0 2.9e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 ESA07381.1 - 0.076 13.5 0.0 0.3 11.6 0.0 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.15 ESA07381.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus zf-DBF PF07535.7 ESA07383.1 - 0.0021 17.6 0.6 0.0021 17.6 0.4 2.3 2 0 0 2 2 2 1 DBF zinc finger zf-C2H2_6 PF13912.1 ESA07383.1 - 2 8.4 7.4 0.23 11.4 1.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger DUF1474 PF07342.6 ESA07383.1 - 4.7 7.4 10.8 0.6 10.3 3.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1474) MULE PF10551.4 ESA07384.1 - 5.7e-05 23.2 2.7 0.00016 21.7 0.0 2.9 3 2 0 3 3 3 1 MULE transposase domain Cactin_mid PF10312.4 ESA07384.1 - 0.032 13.5 0.3 0.068 12.4 0.2 1.5 1 0 0 1 1 1 0 Conserved mid region of cactin Tox-MPTase2 PF15638.1 ESA07384.1 - 0.64 9.5 5.0 1 8.8 3.4 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 TypeIII_RM_meth PF12564.3 ESA07384.1 - 4.2 7.4 9.9 0.2 11.6 1.8 2.5 3 0 0 3 3 3 0 Type III restriction/modification enzyme methylation subunit zf-BED PF02892.10 ESA07387.1 - 0.12 12.2 1.4 0.14 11.9 1.0 1.3 1 0 0 1 1 1 0 BED zinc finger TLD PF07534.11 ESA07388.1 - 1.4e-15 57.5 1.3 2.6e-15 56.6 0.9 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA07388.1 - 4.5e-12 45.9 0.1 9.4e-12 44.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA07388.1 - 7.8e-08 32.0 0.5 5.9e-07 29.2 0.1 2.6 2 1 0 2 2 2 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA07390.1 - 8.3e-49 165.9 0.0 1e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07390.1 - 2.2e-44 151.5 0.1 2.8e-44 151.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kelch_6 PF13964.1 ESA07391.1 - 4.8e-24 83.4 4.2 0.00011 22.2 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA07391.1 - 3.4e-22 77.9 2.8 1.3e-05 24.9 0.0 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA07391.1 - 1e-21 76.4 7.0 1.8e-06 27.9 0.0 6.7 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA07391.1 - 5.2e-14 51.8 7.4 0.018 15.0 0.0 6.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA07391.1 - 2.3e-10 39.7 2.2 0.07 12.9 0.0 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESA07391.1 - 3.6e-09 36.0 1.3 0.055 13.0 0.0 5.4 5 0 0 5 5 5 3 Kelch motif SKG6 PF08693.5 ESA07391.1 - 0.0017 17.5 0.0 0.0044 16.2 0.0 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Piwi PF02171.12 ESA07392.1 - 8.3e-101 336.9 0.0 1.2e-100 336.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA07392.1 - 6.3e-24 83.8 0.1 1.4e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA07392.1 - 6.4e-17 60.6 0.0 1.8e-16 59.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Streptin-Immun PF11083.3 ESA07394.1 - 0.00027 20.8 0.1 0.00044 20.1 0.1 1.4 1 0 0 1 1 1 1 Lantibiotic streptin immunity protein DUF1192 PF06698.6 ESA07394.1 - 0.16 11.7 0.2 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) P2X_receptor PF00864.14 ESA07396.1 - 0.0068 15.1 0.8 0.0077 14.9 0.6 1.1 1 0 0 1 1 1 1 ATP P2X receptor zf-C2H2_7 PF15269.1 ESA07398.1 - 0.0061 16.4 0.5 2 8.3 0.0 3.0 2 0 0 2 2 2 2 Zinc-finger F-box-like PF12937.2 ESA07399.1 - 0.0022 17.6 1.1 0.014 15.1 0.4 2.6 2 1 0 2 2 2 1 F-box-like Josephin PF02099.12 ESA07399.1 - 0.015 14.9 0.0 0.04 13.5 0.0 1.7 1 0 0 1 1 1 0 Josephin DUF1296 PF06972.6 ESA07400.1 - 0.036 14.0 0.2 0.087 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) PAZ PF02170.17 ESA07402.1 - 2.2e-23 82.0 2.5 3.5e-23 81.3 1.7 1.3 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA07402.1 - 2.5e-15 55.5 0.0 6.6e-15 54.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Imm33 PF15580.1 ESA07403.1 - 0.0071 15.8 0.6 2.8 7.4 0.0 2.9 2 1 1 3 3 3 2 Immunity protein 33 Phenol_Hydrox PF02332.13 ESA07403.1 - 0.12 11.6 0.3 5.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Methane/Phenol/Toluene Hydroxylase DUF3914 PF13053.1 ESA07403.1 - 0.47 10.6 2.3 4.3 7.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3914) Kelch_5 PF13854.1 ESA07404.1 - 6.2e-08 32.4 7.2 0.0066 16.3 0.2 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESA07404.1 - 3.2e-07 29.8 3.5 0.12 12.2 0.0 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA07404.1 - 3.1e-05 23.6 4.4 0.17 11.6 0.1 3.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA07404.1 - 4.4e-05 23.4 3.1 2 8.7 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA07404.1 - 0.00062 19.2 4.1 0.061 12.8 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA07404.1 - 0.00076 19.5 1.0 0.12 12.6 0.1 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain zf-C2H2 PF00096.21 ESA07405.1 - 0.00044 20.4 3.9 0.001 19.2 0.3 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA07405.1 - 0.0042 17.1 1.4 0.025 14.7 0.1 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 ESA07405.1 - 0.0091 16.2 1.1 0.046 14.0 0.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger SASRP1 PF15160.1 ESA07405.1 - 0.021 14.0 0.1 0.027 13.6 0.1 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 zf-BED PF02892.10 ESA07405.1 - 0.043 13.5 0.2 0.043 13.5 0.1 2.9 3 0 0 3 3 3 0 BED zinc finger zf-met PF12874.2 ESA07405.1 - 0.061 13.5 3.1 0.071 13.3 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Imm8 PF15560.1 ESA07405.1 - 0.069 12.8 0.7 0.11 12.1 0.4 1.5 1 1 0 1 1 1 0 Immunity protein 8 Ribosomal_L44 PF00935.14 ESA07405.1 - 0.073 13.0 3.9 0.37 10.8 0.0 2.7 3 0 0 3 3 3 0 Ribosomal protein L44 zf-C2H2_2 PF12756.2 ESA07405.1 - 0.18 11.9 3.2 0.7 10.0 0.1 2.6 2 2 0 2 2 2 0 C2H2 type zinc-finger (2 copies) F-box-like PF12937.2 ESA07406.1 - 0.0025 17.5 2.2 0.0025 17.5 1.5 2.4 3 0 0 3 3 3 1 F-box-like Pox_A3L PF05288.6 ESA07406.1 - 1.3 8.8 6.6 0.33 10.7 0.1 3.2 4 0 0 4 4 4 0 Poxvirus A3L Protein F-box-like PF12937.2 ESA07407.1 - 0.026 14.2 3.8 0.029 14.1 1.3 2.0 2 0 0 2 2 2 0 F-box-like DUF29 PF01724.11 ESA07409.1 - 0.51 10.1 5.4 2.1 8.1 1.0 3.2 2 2 1 3 3 3 0 Domain of unknown function DUF29 bZIP_2 PF07716.10 ESA07410.1 - 0.0048 16.6 11.4 0.075 12.8 1.0 3.1 1 1 2 3 3 3 2 Basic region leucine zipper Matrilin_ccoil PF10393.4 ESA07410.1 - 0.0069 15.7 0.2 0.015 14.6 0.2 1.6 1 0 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin HSBP1 PF06825.7 ESA07410.1 - 0.017 14.6 4.3 0.021 14.3 0.5 2.5 2 1 0 2 2 2 0 Heat shock factor binding protein 1 ADIP PF11559.3 ESA07410.1 - 0.019 14.8 5.4 0.026 14.4 3.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.9 ESA07410.1 - 0.034 13.7 5.8 0.042 13.4 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FbpA PF05833.6 ESA07410.1 - 0.044 12.3 7.9 0.05 12.1 5.5 1.0 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DUF972 PF06156.8 ESA07410.1 - 0.058 13.7 9.3 0.46 10.8 6.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) TelA PF05816.6 ESA07410.1 - 0.083 11.5 7.3 0.092 11.4 5.1 1.0 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) CASP_C PF08172.7 ESA07410.1 - 0.1 11.6 4.9 0.11 11.4 3.0 1.4 1 1 0 1 1 1 0 CASP C terminal NICE-3 PF07406.6 ESA07410.1 - 0.16 11.4 1.3 0.2 11.1 0.9 1.1 1 0 0 1 1 1 0 NICE-3 protein DUF1664 PF07889.7 ESA07410.1 - 0.27 11.0 5.4 0.36 10.6 3.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.10 ESA07410.1 - 0.34 10.4 11.6 3.8 7.0 4.9 2.5 1 1 1 2 2 2 0 Septum formation initiator Kinetocho_Slk19 PF12709.2 ESA07410.1 - 0.35 10.9 5.0 0.72 9.9 3.5 1.6 1 1 0 1 1 1 0 Central kinetochore-associated Ax_dynein_light PF10211.4 ESA07410.1 - 0.36 10.6 11.4 0.3 10.8 2.8 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain bZIP_1 PF00170.16 ESA07410.1 - 0.47 10.4 11.3 0.76 9.7 3.3 2.5 1 1 1 2 2 2 0 bZIP transcription factor Shugoshin_N PF07558.6 ESA07410.1 - 0.59 9.8 12.7 0.15 11.8 1.9 3.3 2 1 2 4 4 4 0 Shugoshin N-terminal coiled-coil region DUF904 PF06005.7 ESA07410.1 - 1.4 9.2 12.6 14 6.0 8.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF904) TSC22 PF01166.13 ESA07410.1 - 1.5 8.8 10.1 3.2 7.7 1.8 3.1 1 1 2 3 3 3 0 TSC-22/dip/bun family IncA PF04156.9 ESA07410.1 - 1.8 8.0 6.6 4.4 6.8 4.6 1.6 1 1 0 1 1 1 0 IncA protein DUF3887 PF13026.1 ESA07411.1 - 0.14 12.4 1.2 0.23 11.7 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) MF_alpha_N PF05436.6 ESA07412.1 - 0.11 12.1 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Conotoxin PF02950.12 ESA07412.1 - 0.97 10.2 8.5 21 6.0 5.9 2.1 1 1 0 1 1 1 0 Conotoxin SDA1 PF05285.7 ESA07413.1 - 1.6e-79 267.5 33.9 3.9e-40 138.1 13.4 2.0 1 1 1 2 2 2 2 SDA1 DUF641 PF04859.7 ESA07414.1 - 0.04 13.6 4.0 0.049 13.3 0.7 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc97_Spc98 PF04130.8 ESA07414.1 - 0.1 10.8 1.9 0.11 10.7 1.3 1.0 1 0 0 1 1 1 0 Spc97 / Spc98 family GCD14 PF08704.5 ESA07415.1 - 2.9e-96 321.7 0.1 3.7e-96 321.3 0.1 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 ESA07415.1 - 3e-06 26.8 0.0 5.7e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA07415.1 - 6.7e-06 26.1 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA07415.1 - 2.1e-05 25.0 0.0 3.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESA07415.1 - 3.9e-05 23.2 0.3 7.3e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 ESA07415.1 - 0.0015 17.5 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Fibrillarin PF01269.12 ESA07415.1 - 0.0049 15.8 0.0 0.23 10.3 0.0 2.3 2 0 0 2 2 2 1 Fibrillarin Methyltransf_24 PF13578.1 ESA07415.1 - 0.011 16.5 0.0 0.03 15.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain CMAS PF02353.15 ESA07415.1 - 0.026 13.5 0.0 0.045 12.8 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Gcd10p PF04189.8 ESA07415.1 - 0.04 13.0 0.3 0.54 9.3 0.0 2.2 2 0 0 2 2 2 0 Gcd10p family Methyltransf_11 PF08241.7 ESA07415.1 - 0.04 14.3 0.0 0.086 13.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 ESA07415.1 - 0.063 13.0 0.0 0.14 11.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESA07415.1 - 0.1 11.9 0.0 0.29 10.4 0.0 1.6 1 1 1 2 2 2 0 Methyltransferase small domain Cnd3 PF12719.2 ESA07416.1 - 4.3e-77 259.0 4.7 5.5e-77 258.6 3.2 1.1 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.2 ESA07416.1 - 0.00051 19.9 5.7 0.0015 18.3 3.8 2.1 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DUF1890 PF09001.6 ESA07416.1 - 0.015 15.2 0.1 0.86 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1890) HEAT PF02985.17 ESA07416.1 - 0.043 13.9 0.1 3.8 7.8 0.1 3.0 2 0 0 2 2 2 0 HEAT repeat HEAT_2 PF13646.1 ESA07416.1 - 0.06 13.6 0.0 7.8 6.8 0.0 3.1 2 2 0 2 2 2 0 HEAT repeats MinE PF03776.9 ESA07417.1 - 0.011 15.2 0.3 0.83 9.2 0.1 2.3 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE Pkinase_Tyr PF07714.12 ESA07421.1 - 5.6e-22 78.0 0.1 3e-19 69.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA07421.1 - 7.3e-18 64.6 5.8 1.1e-16 60.7 0.9 2.2 2 0 0 2 2 2 2 Protein kinase domain BCS1_N PF08740.6 ESA07421.1 - 0.017 14.7 0.0 0.62 9.6 0.0 2.2 2 0 0 2 2 2 0 BCS1 N terminal APH PF01636.18 ESA07421.1 - 0.025 14.3 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Alkyl_sulf_C PF14864.1 ESA07421.1 - 0.12 12.3 0.0 6.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal Spt5-NGN PF03439.8 ESA07421.1 - 0.29 10.9 1.4 2.2 8.0 0.1 2.6 2 0 0 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section Pkinase_Tyr PF07714.12 ESA07422.1 - 2.5e-37 128.3 0.3 2.7e-37 128.2 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07422.1 - 2.7e-36 125.0 2.2 3.2e-36 124.8 1.5 1.0 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA07422.1 - 0.00027 20.2 0.6 0.00049 19.3 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA07422.1 - 0.0014 18.0 0.1 0.0021 17.4 0.1 1.4 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA07422.1 - 0.004 16.9 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA07422.1 - 0.0053 15.8 0.1 0.0075 15.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA07422.1 - 0.0081 15.5 0.2 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL ABC1 PF03109.11 ESA07422.1 - 0.017 15.0 0.0 0.23 11.4 0.0 2.4 1 1 0 1 1 1 0 ABC1 family Kinesin-relat_1 PF12711.2 ESA07422.1 - 0.053 13.9 0.9 0.14 12.5 0.2 2.0 2 0 0 2 2 2 0 Kinesin motor Peptidase_S9 PF00326.16 ESA07423.1 - 3e-42 144.2 1.2 3.9e-42 143.8 0.8 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.16 ESA07423.1 - 2.7e-13 49.2 0.2 4.2e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_5 PF12695.2 ESA07423.1 - 2.6e-06 27.2 0.0 4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESA07423.1 - 9e-06 25.2 0.6 3.1e-05 23.5 0.3 1.8 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 ESA07423.1 - 0.0009 19.1 0.0 0.019 14.8 0.0 2.1 1 1 0 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.7 ESA07423.1 - 0.013 13.9 0.0 0.023 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) BAAT_C PF08840.6 ESA07423.1 - 0.15 11.7 0.0 6.2 6.4 0.0 2.1 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal S-methyl_trans PF02574.11 ESA07425.1 - 1.4e-46 159.2 0.0 7.5e-45 153.5 0.0 2.0 1 1 0 1 1 1 1 Homocysteine S-methyltransferase WD40 PF00400.27 ESA07426.1 - 9e-21 72.9 0.5 1.2e-11 43.9 0.3 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat CNH PF00780.17 ESA07426.1 - 0.016 14.6 0.1 0.044 13.1 0.0 1.7 2 0 0 2 2 2 0 CNH domain DUF1236 PF06823.7 ESA07426.1 - 0.12 12.1 1.0 8.4 6.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1236) CENP-B_dimeris PF09026.5 ESA07427.1 - 0.018 15.2 2.2 0.024 14.8 1.6 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PX PF00787.19 ESA07428.1 - 1.4e-08 34.5 1.4 2.2e-08 33.8 0.3 1.8 2 0 0 2 2 2 1 PX domain BEN PF10523.4 ESA07430.1 - 0.0024 17.8 1.3 0.0048 16.9 0.1 2.1 2 0 0 2 2 2 1 BEN domain Z1 PF10593.4 ESA07431.1 - 0.011 15.0 2.9 0.013 14.7 1.7 1.5 1 1 0 1 1 1 0 Z1 domain DUF869 PF05911.6 ESA07431.1 - 0.012 13.8 3.3 0.013 13.7 2.3 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) P4Ha_N PF08336.6 ESA07431.1 - 0.014 15.2 0.4 0.069 12.9 0.0 2.2 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF1664 PF07889.7 ESA07431.1 - 0.21 11.3 2.1 2.1 8.1 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.17 ESA07431.1 - 1.8 8.5 5.2 0.34 10.9 0.2 2.4 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain UPF0223 PF05256.7 ESA07433.1 - 0.0016 18.5 0.5 0.45 10.6 0.1 2.6 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0223) DUF4477 PF14780.1 ESA07433.1 - 0.016 14.5 0.7 0.034 13.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) Syntaxin-18_N PF10496.4 ESA07433.1 - 0.054 13.3 0.3 0.53 10.1 0.0 2.6 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Epsilon_antitox PF08998.6 ESA07433.1 - 0.23 11.4 0.1 0.23 11.4 0.0 3.0 3 1 0 3 3 3 0 Bacterial epsilon antitoxin Syntaxin-6_N PF09177.6 ESA07433.1 - 0.72 10.2 6.8 29 5.1 0.1 4.0 1 1 3 5 5 5 0 Syntaxin 6, N-terminal DUF1492 PF07374.6 ESA07433.1 - 3 7.9 5.9 0.93 9.6 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1492) DUF843 PF05814.6 ESA07434.1 - 0.74 9.6 7.2 0.2 11.4 2.0 2.0 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) Kelch_3 PF13415.1 ESA07435.1 - 1.5e-54 181.0 9.4 2.2e-10 40.4 0.0 6.1 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA07435.1 - 5.7e-50 166.8 15.9 2.9e-10 39.7 0.1 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA07435.1 - 4e-41 137.5 16.1 1.6e-08 34.3 0.1 6.1 3 3 3 6 6 6 6 Kelch motif Kelch_1 PF01344.20 ESA07435.1 - 7.2e-41 137.5 9.6 5.6e-07 29.0 0.3 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.1 ESA07435.1 - 3.9e-38 128.8 18.0 1.3e-09 37.8 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESA07435.1 - 9.2e-32 107.6 10.4 3.5e-06 26.5 0.1 6.2 6 0 0 6 6 6 6 Kelch motif PQQ_3 PF13570.1 ESA07435.1 - 0.017 15.4 7.5 10 6.5 0.1 5.0 6 0 0 6 6 6 0 PQQ-like domain Pkinase_Tyr PF07714.12 ESA07436.1 - 3.9e-50 170.3 0.1 6.6e-50 169.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07436.1 - 3e-45 154.4 2.0 5.1e-45 153.6 1.4 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07436.1 - 0.00044 19.3 0.0 0.00076 18.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mito_carr PF00153.22 ESA07439.1 - 7.6e-21 73.6 0.4 1.9e-13 49.9 0.0 2.6 3 0 0 3 3 3 2 Mitochondrial carrier protein WD40 PF00400.27 ESA07440.1 - 1.9e-60 198.7 20.8 1.2e-11 43.9 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 ESA07440.1 - 2.9e-37 127.8 1.9 8.1e-37 126.4 1.3 1.8 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit LisH PF08513.6 ESA07440.1 - 0.00014 21.4 0.1 0.00043 19.9 0.1 1.9 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 ESA07440.1 - 0.00031 19.0 0.2 0.15 10.1 0.0 3.0 2 2 0 2 2 2 2 Nucleoporin Nup120/160 HMG_box_2 PF09011.5 ESA07441.1 - 0.055 13.8 0.0 0.075 13.4 0.0 1.2 1 0 0 1 1 1 0 HMG-box domain MAT_Alpha1 PF04769.7 ESA07441.1 - 0.07 12.4 0.0 0.085 12.1 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG_box PF00505.14 ESA07441.1 - 0.14 12.3 0.2 0.58 10.4 0.1 1.9 1 1 0 1 1 1 0 HMG (high mobility group) box Retrotrans_gag PF03732.12 ESA07443.1 - 0.02 14.9 0.1 4.3 7.4 0.0 2.8 3 0 0 3 3 3 0 Retrotransposon gag protein HMG_box PF00505.14 ESA07444.1 - 0.018 15.3 3.7 0.059 13.6 0.1 2.7 3 0 0 3 3 3 0 HMG (high mobility group) box DDE_3 PF13358.1 ESA07445.1 - 3.8e-06 26.7 0.0 4.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease FPL PF09758.4 ESA07447.1 - 0.0057 16.4 0.9 0.0066 16.2 0.5 1.3 1 1 0 1 1 1 1 Uncharacterised conserved protein DUF148 PF02520.12 ESA07447.1 - 0.04 13.6 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF1542 PF07564.6 ESA07447.1 - 0.27 11.2 0.4 0.27 11.2 0.3 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Pkinase_Tyr PF07714.12 ESA07448.1 - 1.5e-19 70.0 0.2 1.5e-11 43.9 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA07448.1 - 1.7e-13 50.3 0.2 1.6e-08 34.0 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain DUF869 PF05911.6 ESA07448.1 - 0.00011 20.6 7.3 0.00015 20.2 5.1 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) NTS PF15447.1 ESA07448.1 - 0.027 14.8 1.3 0.061 13.7 0.1 2.2 2 0 0 2 2 2 0 N-terminal segments of PfEMP1 CorA PF01544.13 ESA07448.1 - 0.042 12.8 1.4 0.1 11.6 0.7 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein ALMT PF11744.3 ESA07448.1 - 0.062 11.9 1.7 0.081 11.5 0.4 1.6 1 1 0 1 1 1 0 Aluminium activated malate transporter DUF3936 PF13072.1 ESA07449.1 - 0.4 10.1 3.2 1 8.8 0.5 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3936) Pet20 PF08692.5 ESA07451.1 - 0.039 13.8 0.2 0.049 13.5 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial protein Pet20 HHH_2 PF12826.2 ESA07451.1 - 0.08 12.8 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif Init_tRNA_PT PF04179.7 ESA07451.1 - 0.084 11.7 5.1 0.1 11.4 3.5 1.0 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase DUF1027 PF06265.6 ESA07451.1 - 0.12 12.2 0.7 0.18 11.6 0.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1027) DDE_1 PF03184.14 ESA07453.1 - 4e-22 78.4 0.0 5.9e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA07453.1 - 0.0048 16.6 0.0 0.0094 15.7 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF1381 PF07129.6 ESA07453.1 - 0.042 13.2 0.6 0.09 12.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1381) HTH_Mga PF08280.6 ESA07454.1 - 0.021 14.5 1.1 0.052 13.3 0.2 2.0 1 1 1 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain Phage_int_SAM_3 PF14659.1 ESA07454.1 - 0.092 13.0 1.6 0.25 11.6 0.3 2.1 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Pkinase PF00069.20 ESA07455.1 - 5.6e-21 74.8 0.0 6.1e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07455.1 - 1.2e-19 70.4 0.0 1.2e-19 70.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA07455.1 - 0.0013 18.1 0.1 0.0015 17.9 0.1 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA07455.1 - 0.1 12.2 0.2 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA07455.1 - 0.14 11.2 0.2 0.15 11.0 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4413 PF14372.1 ESA07457.1 - 2.4e-05 24.2 0.2 0.00065 19.6 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4413) Dimer_Tnp_hAT PF05699.9 ESA07458.1 - 2.1e-18 65.7 0.3 2.2e-18 65.6 0.2 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Latarcin PF10279.4 ESA07460.1 - 0.29 11.3 3.4 0.71 10.0 0.9 2.1 1 1 1 2 2 2 0 Latarcin precursor DUF905 PF06006.7 ESA07462.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) Ecl1 PF12855.2 ESA07462.1 - 0.32 10.3 4.5 0.56 9.5 3.1 1.5 1 1 0 1 1 1 0 Life-span regulatory factor DUF2909 PF11137.3 ESA07463.1 - 0.065 12.9 1.4 0.18 11.5 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Syja_N PF02383.13 ESA07464.1 - 0.0032 16.2 0.2 0.0037 16.0 0.1 1.1 1 0 0 1 1 1 1 SacI homology domain RRM_6 PF14259.1 ESA07466.1 - 0.0023 17.8 0.0 0.33 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA07466.1 - 0.098 12.4 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1675 PF07897.6 ESA07466.1 - 0.73 9.6 4.3 1 9.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) Pkinase_Tyr PF07714.12 ESA07467.1 - 1.7e-51 174.7 0.0 2.5e-51 174.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07467.1 - 3.1e-51 174.0 0.5 3.1e-51 174.0 0.4 1.5 2 0 0 2 2 2 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA07467.1 - 8.9e-06 25.1 0.1 1.5e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA07467.1 - 0.0011 18.0 0.0 0.0023 17.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA07467.1 - 0.0031 16.8 0.2 0.0063 15.8 0.1 1.6 1 0 0 1 1 1 1 RIO1 family BIV_Env PF05858.7 ESA07467.1 - 0.016 13.1 0.6 0.027 12.4 0.4 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) APH PF01636.18 ESA07467.1 - 0.049 13.3 0.1 0.1 12.2 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF1237 PF06824.6 ESA07469.1 - 8e-72 242.1 0.1 9e-72 241.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1237) DUF659 PF04937.10 ESA07470.1 - 3.1e-08 33.2 2.4 5e-08 32.5 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) RRM_1 PF00076.17 ESA07472.1 - 0.0064 16.0 0.0 0.014 14.9 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA07472.1 - 0.11 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.20 ESA07473.1 - 6.7e-11 41.8 4.4 2.9e-07 29.9 0.2 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07473.1 - 4.1e-10 39.1 0.0 5.7e-05 22.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase DUF1642 PF07852.6 ESA07473.1 - 0.33 11.2 4.3 0.47 10.7 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1642) BTB PF00651.26 ESA07475.1 - 5.8e-16 58.4 1.2 1.6e-15 57.0 0.1 2.3 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA07475.1 - 8.3e-11 42.0 0.2 1.9e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA07475.1 - 0.0011 18.7 3.5 0.053 13.3 1.1 3.2 1 1 2 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA07476.1 - 1.3e-16 60.5 0.4 2.9e-16 59.4 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA07476.1 - 1.3e-11 44.6 2.1 2.4e-11 43.7 1.1 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA07476.1 - 0.00011 22.0 5.1 0.0029 17.4 0.8 3.4 2 1 2 4 4 4 2 BTB And C-terminal Kelch Sel1 PF08238.7 ESA07477.1 - 6.2e-37 125.2 13.2 8.7e-10 38.9 1.5 5.1 5 0 0 5 5 5 5 Sel1 repeat Prenyltrans_1 PF13243.1 ESA07477.1 - 0.02 14.9 1.2 0.24 11.4 0.3 2.6 1 1 1 2 2 2 0 Prenyltransferase-like V-set PF07686.12 ESA07477.1 - 0.02 14.7 0.1 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin V-set domain TPR_6 PF13174.1 ESA07477.1 - 0.034 14.6 5.6 1.2 9.7 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA07477.1 - 1.1 9.1 12.7 5.1 7.0 0.1 4.8 4 1 2 6 6 6 0 MIT (microtubule interacting and transport) domain DBD_Tnp_Hermes PF10683.4 ESA07482.1 - 0.011 15.2 0.0 0.035 13.5 0.0 1.8 2 0 0 2 2 2 0 Hermes transposase DNA-binding domain DUF2764 PF10962.3 ESA07482.1 - 0.055 12.7 0.0 0.074 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) Peptidase_A4 PF01828.12 ESA07482.1 - 0.12 11.4 0.2 0.65 9.0 0.1 2.0 1 1 1 2 2 2 0 Peptidase A4 family MutL_C PF08676.6 ESA07485.1 - 7e-25 87.3 0.1 3e-24 85.2 0.0 2.0 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 ESA07485.1 - 1.7e-20 72.6 0.3 4.5e-20 71.2 0.2 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 ESA07485.1 - 1.9e-14 53.4 0.0 6.5e-14 51.7 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA07485.1 - 7.4e-11 41.7 0.1 2.6e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.21 ESA07486.1 - 1e-38 131.9 0.1 1.4e-38 131.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SR-25 PF10500.4 ESA07488.1 - 0.037 13.4 7.1 0.045 13.2 4.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zn_clus PF00172.13 ESA07490.1 - 1.7e-06 27.8 15.3 2.9e-06 27.0 10.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CwfJ_C_1 PF04677.10 ESA07491.1 - 3.2e-28 97.8 0.0 4.8e-28 97.2 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 ESA07491.1 - 1.2e-23 83.4 0.1 2.4e-22 79.2 0.0 2.1 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 HIT PF01230.18 ESA07491.1 - 0.0004 20.8 0.1 0.00072 20.0 0.1 1.3 1 0 0 1 1 1 1 HIT domain Arrestin_N PF00339.24 ESA07493.1 - 1.3e-11 44.4 0.8 4.5e-11 42.7 0.1 2.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Phage_gp53 PF11246.3 ESA07494.1 - 0.0061 16.0 0.5 0.0094 15.4 0.4 1.3 1 0 0 1 1 1 1 Base plate wedge protein 53 TINF2_N PF14973.1 ESA07494.1 - 0.074 13.1 0.5 0.15 12.1 0.0 1.6 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus PIF1 PF05970.9 ESA07496.1 - 0.0019 17.2 0.0 0.0019 17.2 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase Phytoreo_P8 PF07124.6 ESA07496.1 - 0.092 11.3 0.0 0.093 11.3 0.0 1.0 1 0 0 1 1 1 0 Phytoreovirus outer capsid protein P8 E1_DerP2_DerF2 PF02221.10 ESA07497.1 - 5.7e-10 39.5 0.5 6.3e-10 39.4 0.4 1.1 1 0 0 1 1 1 1 ML domain DUF4369 PF14289.1 ESA07497.1 - 0.026 14.5 0.1 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4369) Raftlin PF15250.1 ESA07498.1 - 0.018 13.5 0.5 0.02 13.4 0.3 1.0 1 0 0 1 1 1 0 Raftlin Peptidase_M49 PF03571.10 ESA07498.1 - 0.053 11.5 1.5 0.06 11.4 1.0 1.0 1 0 0 1 1 1 0 Peptidase family M49 FliJ PF02050.11 ESA07499.1 - 1.4e-05 25.1 1.0 4.7e-05 23.4 0.7 1.8 1 1 0 1 1 1 1 Flagellar FliJ protein Prefoldin_2 PF01920.15 ESA07499.1 - 0.022 14.5 1.3 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit Plasmod_dom_1 PF09715.5 ESA07499.1 - 0.031 14.1 0.7 2.2 8.2 0.1 2.3 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) IncA PF04156.9 ESA07499.1 - 0.058 12.9 1.9 0.53 9.8 0.3 2.2 2 0 0 2 2 2 0 IncA protein DASH_Duo1 PF08651.5 ESA07499.1 - 0.077 12.5 0.6 0.23 11.0 0.4 1.8 1 1 0 1 1 1 0 DASH complex subunit Duo1 MbeB_N PF04837.7 ESA07499.1 - 0.31 11.1 0.3 0.31 11.1 0.2 2.1 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Prefoldin PF02996.12 ESA07499.1 - 0.57 9.8 3.4 4.3 7.0 0.1 2.8 3 0 0 3 3 3 0 Prefoldin subunit Proteasom_PSMB PF10508.4 ESA07501.1 - 0.13 10.5 0.1 0.14 10.3 0.0 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit DUF420 PF04238.7 ESA07502.1 - 0.0092 15.9 3.1 0.017 15.0 2.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF420) MARVEL PF01284.18 ESA07502.1 - 0.018 14.8 5.9 0.045 13.5 3.8 1.9 1 1 0 1 1 1 0 Membrane-associating domain 7TM_GPCR_Srv PF10323.4 ESA07502.1 - 0.034 13.2 10.5 0.043 12.9 7.3 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv SieB PF14163.1 ESA07502.1 - 0.15 11.6 0.2 0.15 11.6 0.1 2.5 1 1 2 3 3 3 0 Superinfection exclusion protein B DUF2516 PF10724.4 ESA07502.1 - 4 7.4 7.5 1.2 9.1 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2516) FAD_binding_4 PF01565.18 ESA07504.1 - 6.3e-23 80.7 0.0 8.8e-23 80.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain PQ-loop PF04193.9 ESA07505.1 - 2.9e-21 74.7 15.9 4.9e-16 58.0 1.1 3.4 3 0 0 3 3 3 2 PQ loop repeat MNHE PF01899.11 ESA07505.1 - 0.049 13.2 0.4 0.085 12.4 0.2 1.4 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit Rhabdo_glycop PF00974.13 ESA07505.1 - 0.074 11.2 0.6 0.64 8.1 0.0 2.0 2 0 0 2 2 2 0 Rhabdovirus spike glycoprotein Pox_A14 PF05767.7 ESA07505.1 - 0.3 11.0 7.4 0.38 10.7 0.2 2.8 2 2 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF2418 PF10332.4 ESA07505.1 - 0.85 9.9 0.0 0.85 9.9 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2418) Peptidase_M50 PF02163.17 ESA07505.1 - 5.5 5.8 6.9 1.3 7.9 0.2 2.5 2 1 0 3 3 3 0 Peptidase family M50 Pkinase_Tyr PF07714.12 ESA07506.1 - 9.6e-15 54.3 0.0 1.9e-14 53.3 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07506.1 - 5.2e-14 52.0 0.0 8e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain AAA_5 PF07728.9 ESA07507.1 - 1.4e-05 24.8 0.0 0.00019 21.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA07507.1 - 0.00012 22.2 0.1 0.027 14.6 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA07507.1 - 0.0014 18.7 2.8 1.1 9.4 0.2 3.9 3 1 1 4 4 4 2 AAA domain Sigma54_activ_2 PF14532.1 ESA07507.1 - 0.0016 18.5 0.0 0.48 10.4 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 ESA07507.1 - 0.0023 17.8 0.1 0.037 13.9 0.0 2.9 2 1 1 3 3 3 1 AAA domain NACHT PF05729.7 ESA07507.1 - 0.0078 15.8 0.1 1.3 8.6 0.0 3.0 3 0 0 3 3 3 1 NACHT domain Miro PF08477.8 ESA07507.1 - 0.021 15.3 0.6 0.18 12.3 0.0 2.9 3 1 0 3 3 3 0 Miro-like protein AAA_16 PF13191.1 ESA07507.1 - 0.025 14.5 0.0 2.1 8.3 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 ESA07507.1 - 0.03 14.6 0.0 1.9 8.7 0.0 2.7 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.17 ESA07507.1 - 0.033 14.3 0.1 3.4 7.8 0.0 3.4 3 0 0 3 3 3 0 RNA helicase Sigma54_activat PF00158.21 ESA07507.1 - 0.053 12.9 0.0 10 5.5 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_18 PF13238.1 ESA07507.1 - 0.08 13.2 0.8 0.82 9.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain MIF4G PF02854.14 ESA07508.1 - 4.9e-44 150.2 9.1 6.4e-44 149.8 6.3 1.1 1 0 0 1 1 1 1 MIF4G domain DUF4041 PF13250.1 ESA07508.1 - 0.081 12.5 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) BACK PF07707.10 ESA07509.1 - 1e-08 34.9 0.7 6.5e-06 25.9 0.1 3.1 1 1 2 3 3 3 2 BTB And C-terminal Kelch Band_7_1 PF13421.1 ESA07509.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 SPFH domain-Band 7 family BTB PF00651.26 ESA07510.1 - 2e-05 24.5 1.8 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA07510.1 - 0.099 12.4 1.2 1.2 8.9 0.2 2.7 1 1 1 2 2 2 0 BTB And C-terminal Kelch ACOX PF01756.14 ESA07511.1 - 8.3e-43 145.9 3.0 2.4e-42 144.4 2.0 1.7 1 1 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.19 ESA07511.1 - 7.9e-07 29.2 0.0 1.8e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Myco_arth_vir_N PF09610.5 ESA07512.1 - 0.035 14.0 0.1 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) DUF1152 PF06626.7 ESA07513.1 - 0.089 11.8 0.0 0.14 11.2 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1152) CHD5 PF04420.9 ESA07513.1 - 0.14 11.8 3.9 0.18 11.4 2.7 1.2 1 0 0 1 1 1 0 CHD5-like protein Dimer_Tnp_hAT PF05699.9 ESA07514.1 - 3.6e-19 68.1 0.1 3.9e-19 68.0 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Leukocidin PF07968.7 ESA07515.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Leukocidin/Hemolysin toxin family DUF547 PF04784.9 ESA07517.1 - 0.018 14.9 0.1 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF547 TFIIA PF03153.8 ESA07519.1 - 0.0034 17.3 4.7 0.0042 17.0 3.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PWWP PF00855.12 ESA07521.1 - 1.2e-17 63.8 0.5 1.2e-17 63.8 0.3 3.0 2 2 0 2 2 2 1 PWWP domain IBR PF01485.16 ESA07524.1 - 3e-05 23.8 9.6 3e-05 23.8 6.7 5.2 4 2 1 5 5 5 3 IBR domain ER PF01133.12 ESA07525.1 - 0.07 12.8 0.1 0.07 12.8 0.1 1.1 1 0 0 1 1 1 0 Enhancer of rudimentary DUF3594 PF12165.3 ESA07526.1 - 0.043 13.4 0.0 0.051 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3594) CmcI PF04989.7 ESA07526.1 - 0.12 11.6 0.0 0.13 11.6 0.0 1.0 1 0 0 1 1 1 0 Cephalosporin hydroxylase ARS2 PF04959.8 ESA07528.1 - 1.6e-19 71.0 2.5 2.8e-19 70.1 1.7 1.3 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.1 ESA07528.1 - 3.4e-16 58.5 0.2 8.5e-16 57.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) zf-C2H2_2 PF12756.2 ESA07528.1 - 2.2e-05 24.5 5.2 0.0032 17.5 0.8 2.7 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) DUF1336 PF07059.7 ESA07528.1 - 0.017 14.5 1.3 0.02 14.3 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1336) zf-C2H2_4 PF13894.1 ESA07528.1 - 0.019 15.2 3.1 0.26 11.7 0.4 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.10 ESA07528.1 - 0.046 13.4 2.0 1.3 8.8 0.4 2.6 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.1 ESA07528.1 - 0.063 13.5 0.9 0.063 13.5 0.6 2.7 3 0 0 3 3 3 0 Zinc-finger double domain PyrI_C PF02748.10 ESA07528.1 - 0.089 12.2 2.2 8.8 5.8 0.1 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 PF00096.21 ESA07528.1 - 1.9 8.9 7.7 0.31 11.4 2.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type SWIRM PF04433.12 ESA07529.1 - 2.7e-15 56.2 1.5 4.5e-15 55.5 0.0 2.1 2 1 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.26 ESA07529.1 - 1.3e-09 37.9 0.1 2.6e-09 36.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.12 ESA07529.1 - 1.2e-08 34.3 6.3 1.9e-08 33.6 4.4 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.1 ESA07529.1 - 9.2e-06 25.6 0.0 3.4e-05 23.8 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3861 PF12977.2 ESA07530.1 - 0.062 13.4 1.3 0.11 12.6 0.9 1.5 1 1 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3861) DNA_pol_B_exo1 PF03104.14 ESA07532.1 - 3e-15 55.8 0.4 1.1e-12 47.4 0.2 2.1 1 1 1 2 2 2 2 DNA polymerase family B, exonuclease domain TLD PF07534.11 ESA07533.1 - 7.5e-15 55.1 0.8 7.5e-15 55.1 0.6 1.7 2 0 0 2 2 2 1 TLD Kelch_5 PF13854.1 ESA07534.1 - 5.3e-14 51.8 11.4 0.0065 16.4 0.1 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA07534.1 - 3.3e-12 46.2 3.3 0.014 15.5 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA07534.1 - 4.9e-12 45.1 4.1 0.011 15.4 0.0 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA07534.1 - 6.5e-12 44.8 21.2 0.00053 19.4 0.5 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA07534.1 - 1e-11 44.4 14.5 0.0019 18.2 0.3 5.4 5 2 1 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESA07534.1 - 1e-10 41.2 10.5 0.00097 18.8 0.0 5.7 6 0 0 6 6 6 4 Galactose oxidase, central domain Ndc1_Nup PF09531.5 ESA07537.1 - 0.92 7.8 4.4 1.1 7.6 3.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LPP20 PF02169.11 ESA07537.1 - 1.8 8.6 10.3 14 5.8 7.1 2.2 1 1 0 1 1 1 0 LPP20 lipoprotein NDUF_B12 PF08122.7 ESA07538.1 - 1.3e-15 56.8 0.5 1.6e-15 56.5 0.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family ALIX_LYPXL_bnd PF13949.1 ESA07539.1 - 1.5e-06 27.4 9.7 2.4e-06 26.7 6.7 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV MAD PF05557.8 ESA07539.1 - 0.00065 17.9 1.1 0.00065 17.9 0.8 1.8 3 0 0 3 3 3 1 Mitotic checkpoint protein Nucleoporin_FG PF13634.1 ESA07539.1 - 0.0013 18.8 73.4 1.4 9.1 39.1 3.5 2 1 0 2 2 2 1 Nucleoporin FG repeat region Syntaxin-6_N PF09177.6 ESA07539.1 - 0.01 16.2 6.4 0.038 14.3 0.1 3.1 2 2 1 3 3 3 0 Syntaxin 6, N-terminal IncA PF04156.9 ESA07539.1 - 0.022 14.3 7.1 0.41 10.2 0.6 2.3 2 0 0 2 2 2 0 IncA protein BLOC1_2 PF10046.4 ESA07539.1 - 0.077 13.1 10.2 7.2 6.8 0.1 4.1 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Toxin-deaminase PF14424.1 ESA07539.1 - 0.24 11.3 2.8 0.43 10.5 0.6 2.2 2 1 0 2 2 2 0 The BURPS668_1122 family of deaminases DUF4600 PF15372.1 ESA07539.1 - 0.3 11.3 4.3 0.16 12.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) TBPIP PF07106.8 ESA07539.1 - 0.74 9.3 9.2 0.9 9.0 0.3 2.8 2 2 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Rootletin PF15035.1 ESA07539.1 - 2.7 7.9 11.1 0.63 9.9 4.4 2.5 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1319 PF07028.6 ESA07539.1 - 6.1 7.0 8.1 4.5 7.4 0.5 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1319) Vps26 PF03643.10 ESA07542.1 - 0.16 10.7 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Sel1 PF08238.7 ESA07544.1 - 2.4e-60 199.6 18.7 7.6e-12 45.4 1.3 9.0 9 0 0 9 9 9 8 Sel1 repeat DUF2779 PF11074.3 ESA07544.1 - 0.029 14.4 0.0 0.54 10.3 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function(DUF2779) DUF2989 PF11207.3 ESA07544.1 - 0.077 12.4 15.6 0.26 10.6 0.3 4.0 1 1 2 4 4 4 0 Protein of unknown function (DUF2989) TPR_20 PF14561.1 ESA07544.1 - 0.15 12.1 6.4 16 5.7 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESA07544.1 - 0.55 10.2 4.3 20 5.2 0.0 4.2 5 0 0 5 5 5 0 PPR repeat family MIT PF04212.13 ESA07544.1 - 0.75 9.7 16.1 7.4 6.5 0.6 5.4 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA07544.1 - 3.3 8.3 13.0 25 5.6 0.3 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07544.1 - 6.6 6.4 23.2 0.22 11.1 0.4 5.1 2 2 4 7 7 7 0 TPR repeat SWIRM PF04433.12 ESA07545.1 - 2.4e-11 43.6 0.3 1.6e-10 40.9 0.0 2.3 2 0 0 2 2 2 1 SWIRM domain DUF480 PF04337.7 ESA07545.1 - 4.3 7.1 8.2 3.5 7.4 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function, DUF480 F-box-like_2 PF13013.1 ESA07547.1 - 0.037 13.7 2.6 3.2 7.5 0.2 2.3 1 1 1 2 2 2 0 F-box-like domain LRR_8 PF13855.1 ESA07547.1 - 0.093 12.5 10.8 0.68 9.7 2.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat zf-C2H2_4 PF13894.1 ESA07548.1 - 0.0015 18.7 1.1 0.0015 18.7 0.7 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA07548.1 - 0.053 13.4 0.2 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA07548.1 - 0.15 12.4 0.4 0.15 12.4 0.3 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type ACT PF01842.20 ESA07549.1 - 1.3e-13 50.0 0.1 1.8e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 ESA07549.1 - 4.2e-12 45.7 0.0 5.8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 ACT domain F-box-like PF12937.2 ESA07551.1 - 8.3e-06 25.4 0.2 1.8e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA07551.1 - 0.004 16.7 0.4 0.019 14.6 0.0 2.4 2 0 0 2 2 2 1 F-box domain PAH PF02671.16 ESA07551.1 - 0.073 12.7 0.8 0.63 9.6 0.0 2.9 2 1 0 2 2 2 0 Paired amphipathic helix repeat AChE_tetra PF08674.5 ESA07552.1 - 0.81 9.2 3.7 0.82 9.2 0.1 2.3 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain Peripla_BP_1 PF00532.16 ESA07553.1 - 0.037 13.2 0.0 0.045 12.9 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family HMG_box PF00505.14 ESA07554.1 - 0.0012 19.0 1.8 0.02 15.1 1.2 2.5 1 1 0 1 1 1 1 HMG (high mobility group) box DUF4047 PF13256.1 ESA07555.1 - 0.41 10.5 3.8 1 9.3 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4047) Pkinase_Tyr PF07714.12 ESA07556.1 - 1e-16 60.8 0.1 1.3e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07556.1 - 7e-14 51.5 1.3 9.7e-14 51.1 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Amidohydro_1 PF01979.15 ESA07557.1 - 3e-15 56.7 0.0 3.8e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family A_deaminase PF00962.17 ESA07557.1 - 0.00032 19.7 0.0 0.00041 19.3 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_3 PF07969.6 ESA07557.1 - 0.051 12.7 0.0 0.07 12.3 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family HD_4 PF13328.1 ESA07559.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 HD domain HMG_box PF00505.14 ESA07561.1 - 5e-10 39.5 0.2 6.2e-10 39.1 0.1 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07561.1 - 0.003 17.9 0.5 0.0038 17.5 0.3 1.1 1 0 0 1 1 1 1 HMG-box domain SopE_GEF PF07487.8 ESA07562.1 - 0.14 12.1 2.2 0.15 11.9 1.2 1.4 1 1 0 1 1 1 0 SopE GEF domain CUB_2 PF02408.15 ESA07562.1 - 1.1 8.7 14.3 0.25 10.8 6.8 1.9 1 1 1 2 2 2 0 CUB-like domain Pyocin_S PF06958.7 ESA07562.1 - 1.8 8.9 8.3 66 3.8 5.7 2.0 1 1 0 1 1 1 0 S-type Pyocin Smr PF01713.16 ESA07564.1 - 1.4e-05 25.1 0.0 1.5e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Smr domain MreB_Mbl PF06723.8 ESA07566.1 - 0.09 11.3 0.1 7.6 5.0 0.1 2.4 2 1 0 2 2 2 0 MreB/Mbl protein Transformer PF06495.6 ESA07567.1 - 0.32 10.8 5.8 0.49 10.2 4.0 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein Kelch_4 PF13418.1 ESA07568.1 - 3.3e-19 68.3 8.0 0.00035 20.2 0.0 5.8 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA07568.1 - 6.6e-15 54.6 2.7 0.0009 19.1 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESA07568.1 - 5.8e-14 51.5 8.6 0.00015 21.7 0.4 5.4 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ESA07568.1 - 2.6e-13 49.1 3.6 0.00056 19.5 0.0 5.5 4 1 1 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA07568.1 - 7.9e-12 44.9 0.2 0.0067 16.5 0.0 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA07568.1 - 1.5e-08 33.9 5.0 0.027 14.0 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.6 ESA07568.1 - 0.041 12.9 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus Rtt106 PF08512.7 ESA07569.1 - 0.13 12.2 0.1 0.2 11.6 0.0 1.4 1 1 0 1 1 1 0 Histone chaperone Rttp106-like Uma2 PF05685.7 ESA07570.1 - 5.5e-14 51.8 0.0 6.7e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease zf-C2H2_4 PF13894.1 ESA07570.1 - 0.011 15.9 0.3 0.011 15.9 0.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESA07570.1 - 0.024 14.7 0.3 0.042 13.9 0.2 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESA07570.1 - 0.032 14.5 0.2 0.075 13.4 0.2 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type WAK PF08488.6 ESA07570.1 - 0.06 13.6 0.2 9.5 6.5 0.0 2.5 1 1 1 2 2 2 0 Wall-associated kinase zf-CHCC PF10276.4 ESA07570.1 - 0.13 12.1 1.1 0.29 10.9 0.8 1.6 1 0 0 1 1 1 0 Zinc-finger domain Adeno_E3_CR1 PF02440.10 ESA07571.1 - 0.005 16.2 0.2 0.0072 15.7 0.2 1.3 1 0 0 1 1 1 1 Adenovirus E3 region protein CR1 HAUS-augmin3 PF14932.1 ESA07571.1 - 0.085 12.0 1.6 0.096 11.8 1.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 EST1 PF10374.4 ESA07571.1 - 0.11 12.4 0.6 0.13 12.2 0.4 1.2 1 0 0 1 1 1 0 Telomerase activating protein Est1 MitMem_reg PF13012.1 ESA07572.1 - 0.062 13.3 0.3 0.067 13.2 0.2 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function CCDC74_C PF14917.1 ESA07572.1 - 0.096 12.7 0.6 0.1 12.6 0.4 1.1 1 0 0 1 1 1 0 Coiled coil protein 74, C terminal KIAA1430 PF13879.1 ESA07573.1 - 0.075 13.4 0.2 0.077 13.4 0.1 1.2 1 0 0 1 1 1 0 KIAA1430 homologue DndB PF14072.1 ESA07573.1 - 0.083 12.0 0.2 0.083 12.0 0.1 1.0 1 0 0 1 1 1 0 DNA-sulfur modification-associated S1FA PF04689.8 ESA07575.1 - 0.31 10.9 2.2 2.6 8.0 0.8 2.3 2 0 0 2 2 2 0 DNA binding protein S1FA Ion_trans PF00520.26 ESA07575.1 - 0.34 10.1 5.3 0.57 9.4 3.7 1.4 1 0 0 1 1 1 0 Ion transport protein AIG1 PF04548.11 ESA07576.1 - 8.7e-20 70.7 3.4 8.7e-20 70.7 2.3 1.4 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA07576.1 - 1.2e-08 34.9 2.2 1.3e-07 31.5 0.4 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase Sigma54_activat PF00158.21 ESA07576.1 - 0.0027 17.2 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Spectrin PF00435.16 ESA07576.1 - 0.0035 17.5 1.7 0.0083 16.3 1.2 1.6 1 0 0 1 1 1 1 Spectrin repeat DUF258 PF03193.11 ESA07576.1 - 0.0071 15.5 0.1 0.02 14.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA07576.1 - 0.017 15.4 5.8 0.089 13.0 4.0 2.3 1 1 0 1 1 1 0 ABC transporter U3_assoc_6 PF08640.6 ESA07576.1 - 0.017 14.8 3.3 0.043 13.5 2.3 1.6 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 Msg2_C PF12373.3 ESA07576.1 - 0.018 14.2 0.7 0.32 10.2 0.0 2.7 3 0 0 3 3 3 0 Major surface glycoprotein 2 C terminal AAA_10 PF12846.2 ESA07576.1 - 0.02 14.3 1.3 0.052 12.9 0.9 1.7 1 1 0 1 1 1 0 AAA-like domain Septin PF00735.13 ESA07576.1 - 0.024 13.6 0.5 0.024 13.6 0.3 2.1 3 0 0 3 3 3 0 Septin Miro PF08477.8 ESA07576.1 - 0.027 14.9 1.5 0.037 14.5 0.1 1.9 2 0 0 2 2 1 0 Miro-like protein AAA PF00004.24 ESA07576.1 - 0.087 13.0 1.3 0.4 10.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2076 PF09849.4 ESA07576.1 - 0.092 12.7 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) AAA_29 PF13555.1 ESA07576.1 - 0.1 12.1 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 ESA07576.1 - 0.1 11.4 2.6 0.081 11.8 0.3 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein EcoEI_R_C PF08463.5 ESA07576.1 - 0.12 12.2 5.6 0.7 9.7 0.1 2.5 2 1 0 2 2 2 0 EcoEI R protein C-terminal Tom5 PF10642.4 ESA07576.1 - 0.13 11.9 1.2 0.23 11.1 0.3 1.8 2 0 0 2 2 1 0 Mitochondrial import receptor subunit or translocase AAA_22 PF13401.1 ESA07576.1 - 0.15 12.2 1.6 2.4 8.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.13 ESA07576.1 - 0.26 10.5 2.3 7.2 5.8 0.1 2.5 1 1 1 2 2 2 0 Ferrous iron transport protein B ArgK PF03308.11 ESA07576.1 - 0.3 9.8 6.1 1.2 7.7 0.2 2.4 2 0 0 2 2 2 0 ArgK protein OmpH PF03938.9 ESA07576.1 - 0.35 10.7 4.0 0.72 9.7 2.8 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_17 PF13207.1 ESA07576.1 - 0.73 10.6 2.9 3.5 8.4 2.0 2.2 1 1 0 1 1 1 0 AAA domain APG6 PF04111.7 ESA07576.1 - 1.7 7.5 13.4 2.7 6.9 9.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 RRF PF01765.14 ESA07576.1 - 4.8 6.6 13.5 2.7 7.4 7.3 2.0 1 1 1 2 2 2 0 Ribosome recycling factor AAA_23 PF13476.1 ESA07576.1 - 7.5 6.8 17.8 21 5.3 12.3 1.7 1 1 0 1 1 1 0 AAA domain Tubulin PF00091.20 ESA07577.1 - 2.5e-71 239.9 0.0 3.8e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESA07577.1 - 1.9e-45 153.9 0.2 1.9e-45 153.9 0.1 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESA07577.1 - 0.0014 18.6 0.0 0.0047 16.9 0.0 1.8 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESA07577.1 - 0.027 13.9 0.0 0.064 12.7 0.0 1.7 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.1 ESA07577.1 - 0.086 11.7 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin like ThiS PF02597.15 ESA07578.1 - 4.4e-12 46.2 0.0 6.5e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 ThiS family HSP70 PF00012.15 ESA07580.1 - 6.1e-171 569.3 7.7 6.1e-171 569.3 5.3 3.1 2 1 1 3 3 3 1 Hsp70 protein MreB_Mbl PF06723.8 ESA07580.1 - 2.2e-12 46.2 0.0 3.9e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein DRIM PF07539.7 ESA07580.1 - 0.007 15.7 0.1 0.018 14.4 0.0 1.7 1 0 0 1 1 1 1 Down-regulated in metastasis Suf PF05843.9 ESA07580.1 - 9.3 5.8 15.3 0.12 12.1 1.4 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) GAGA_bind PF06217.7 ESA07580.1 - 9.4 6.1 21.9 2.2 8.1 3.0 2.4 2 0 0 2 2 2 0 GAGA binding protein-like family AMIN PF11741.3 ESA07581.1 - 0.024 14.5 0.2 0.041 13.8 0.2 1.3 1 0 0 1 1 1 0 AMIN domain IL3 PF02059.10 ESA07581.1 - 0.029 14.3 0.2 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Interleukin-3 Aminotran_4 PF01063.14 ESA07581.1 - 0.056 12.9 0.0 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class IV Kinetocho_Slk19 PF12709.2 ESA07581.1 - 0.087 12.9 0.1 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 Central kinetochore-associated Pkinase PF00069.20 ESA07582.1 - 1e-24 87.1 1.1 1.2e-24 86.9 0.8 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07582.1 - 1.5e-24 86.4 0.2 1.8e-24 86.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase YebG PF07130.7 ESA07582.1 - 0.028 14.1 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 YebG protein DUF2774 PF11242.3 ESA07583.1 - 0.043 13.7 0.5 0.094 12.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Pkinase PF00069.20 ESA07584.1 - 1.9e-30 105.8 0.2 7.8e-30 103.8 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07584.1 - 2.9e-25 88.8 0.0 9.9e-25 87.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA07584.1 - 0.0017 17.7 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA07584.1 - 0.0026 17.5 0.7 0.0059 16.3 0.5 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA07584.1 - 0.034 13.3 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA07584.1 - 0.076 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SART-1 PF03343.8 ESA07586.1 - 0.026 12.8 1.2 0.032 12.5 0.8 1.1 1 0 0 1 1 1 0 SART-1 family Med3 PF11593.3 ESA07586.1 - 0.12 11.6 3.6 0.15 11.2 2.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3487 PF11990.3 ESA07589.1 - 0.023 14.0 0.2 0.036 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Caveolin PF01146.12 ESA07589.1 - 0.13 11.8 2.0 0.18 11.3 1.4 1.3 1 0 0 1 1 1 0 Caveolin Cation_ATPase_C PF00689.16 ESA07591.1 - 3.1e-42 144.1 6.7 4.8e-42 143.5 4.7 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA07591.1 - 2.1e-33 116.5 0.1 6.2e-32 111.7 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA07591.1 - 1.3e-21 76.3 0.0 2.4e-21 75.4 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESA07591.1 - 2e-14 54.2 0.0 3.4e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESA07591.1 - 5.8e-11 41.8 2.3 5.8e-11 41.8 1.6 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.7 ESA07591.1 - 1.4e-06 28.1 4.2 0.00029 20.5 1.9 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase OST3_OST6 PF04756.8 ESA07593.1 - 0.019 14.4 5.1 0.048 13.2 0.7 2.3 1 1 1 2 2 2 0 OST3 / OST6 family GlutR_N PF05201.10 ESA07593.1 - 0.092 12.3 0.2 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain DUF1170 PF06663.8 ESA07594.1 - 0.0011 18.8 0.5 0.36 10.7 1.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1170) PhnJ PF06007.6 ESA07594.1 - 0.079 11.7 0.2 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnJ RdRP PF05183.7 ESA07598.1 - 1.7e-07 30.3 0.0 4.6e-07 28.9 0.0 1.6 1 1 1 2 2 2 1 RNA dependent RNA polymerase DUF2521 PF10730.4 ESA07599.1 - 0.063 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) TRAUB PF08164.7 ESA07599.1 - 0.33 11.0 3.6 0.59 10.2 2.4 1.6 1 1 0 1 1 1 0 Apoptosis-antagonizing transcription factor, C-terminal DUF2724 PF10893.3 ESA07599.1 - 0.51 10.2 2.8 4.2 7.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2724) DDE_1 PF03184.14 ESA07600.1 - 2.7e-50 170.5 0.3 3.7e-50 170.0 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.8 ESA07600.1 - 0.00012 21.3 0.2 0.00024 20.4 0.1 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_3 PF13358.1 ESA07600.1 - 0.0027 17.4 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease Baculo_gp41 PF04700.7 ESA07601.1 - 0.093 12.1 2.0 0.096 12.1 0.1 1.9 2 1 1 3 3 3 0 Structural glycoprotein p40/gp41 conserved region Pkinase_Tyr PF07714.12 ESA07603.1 - 2.3e-45 154.7 0.0 3.1e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07603.1 - 7.2e-41 140.0 0.0 1.1e-40 139.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07603.1 - 0.0081 15.2 0.2 0.013 14.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA07603.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA07603.1 - 0.016 14.9 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsbU PF06514.6 ESA07603.1 - 0.018 14.8 0.3 0.26 11.1 0.0 2.6 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) Y_Y_Y PF07495.8 ESA07604.1 - 0.076 12.7 1.3 0.18 11.5 0.6 1.8 1 1 1 2 2 2 0 Y_Y_Y domain DUF2142 PF09913.4 ESA07604.1 - 0.25 9.9 0.6 0.42 9.2 0.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) Sec1 PF00995.18 ESA07605.1 - 3.2e-111 372.7 0.0 3.7e-111 372.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF2132 PF09905.4 ESA07605.1 - 0.13 12.2 0.1 0.39 10.6 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2132) HIT PF01230.18 ESA07606.1 - 1.4e-24 86.4 0.0 1.8e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 ESA07606.1 - 6e-12 45.8 0.0 7.9e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CFC PF09443.5 ESA07606.1 - 0.048 13.3 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) CwfJ_C_1 PF04677.10 ESA07606.1 - 0.11 12.1 0.9 0.23 11.1 0.6 1.7 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 SCA7 PF08313.7 ESA07607.1 - 1.8e-07 30.6 1.2 4.6e-07 29.3 0.8 1.7 1 0 0 1 1 1 1 SCA7, zinc-binding domain Init_tRNA_PT PF04179.7 ESA07607.1 - 0.015 14.2 3.1 0.016 14.1 2.1 1.0 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase DUF3912 PF13051.1 ESA07608.1 - 0.11 12.2 0.8 0.11 12.2 0.2 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) OB_NTP_bind PF07717.11 ESA07610.1 - 3.9e-32 110.4 0.0 6.1e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESA07610.1 - 3.4e-30 104.0 0.1 5.5e-30 103.3 0.1 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESA07610.1 - 2.8e-10 39.9 0.1 5.6e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2408 PF10303.4 ESA07611.1 - 8.2e-57 191.0 0.4 2.4e-27 95.6 0.0 5.1 2 2 3 5 5 5 5 Protein of unknown function (DUF2408) Snapin_Pallidin PF14712.1 ESA07611.1 - 0.0028 17.9 6.5 6.4 7.1 0.0 4.7 4 2 0 5 5 5 2 Snapin/Pallidin tRNA-synt_His PF13393.1 ESA07611.1 - 0.12 11.4 0.3 3.3 6.6 0.0 2.5 2 1 1 3 3 3 0 Histidyl-tRNA synthetase BTB PF00651.26 ESA07612.1 - 4.7e-08 33.0 0.0 1.2e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain DnaA_N PF11638.3 ESA07612.1 - 0.048 13.2 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 DnaA N-terminal domain HopW1-1 PF15457.1 ESA07613.1 - 0.07 12.1 1.7 0.092 11.7 0.2 1.7 2 0 0 2 2 2 0 Type III T3SS secreted effector HopW1-1/HopPmaA Med27 PF11571.3 ESA07613.1 - 0.14 12.2 0.2 0.72 10.0 0.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 27 DUF883 PF05957.8 ESA07613.1 - 0.45 10.9 4.6 4.4 7.7 0.1 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Syntaxin-6_N PF09177.6 ESA07613.1 - 1.3 9.4 23.3 0.049 14.0 1.2 3.8 2 1 2 4 4 4 0 Syntaxin 6, N-terminal Trypan_glycop PF00913.14 ESA07613.1 - 1.5 7.6 16.4 0.59 8.9 1.8 2.5 1 1 2 3 3 3 0 Trypanosome variant surface glycoprotein (A-type) DUF948 PF06103.6 ESA07613.1 - 3.2 7.6 14.3 0.24 11.2 2.3 3.5 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Lipoprotein_20 PF13942.1 ESA07613.1 - 4.9 6.6 12.2 0.44 10.0 0.6 3.1 3 0 0 3 3 3 0 YfhG lipoprotein DUF2450 PF10475.4 ESA07613.1 - 6.4 5.5 24.1 0.15 10.9 8.0 2.4 1 1 1 2 2 2 0 Protein of unknown function N-terminal domain (DUF2450) CRT-like PF08627.5 ESA07614.1 - 0.022 14.7 4.5 0.054 13.4 0.2 2.4 2 1 0 2 2 2 0 CRT-like Spc7 PF08317.6 ESA07614.1 - 0.034 12.8 13.0 0.019 13.6 7.5 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein L_lactis_ph-MCP PF06673.6 ESA07614.1 - 0.051 12.3 8.9 0.071 11.8 6.2 1.2 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein ALS_ss_C PF10369.4 ESA07614.1 - 0.066 12.9 1.6 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 Small subunit of acetolactate synthase DivIC PF04977.10 ESA07614.1 - 0.089 12.2 8.4 0.23 10.9 5.8 1.8 1 0 0 1 1 1 0 Septum formation initiator DUF4047 PF13256.1 ESA07614.1 - 0.1 12.5 13.1 0.085 12.8 8.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) SPX PF03105.14 ESA07614.1 - 0.11 12.2 8.8 0.19 11.5 6.1 1.4 1 0 0 1 1 1 0 SPX domain DUF4337 PF14235.1 ESA07614.1 - 0.11 12.2 7.7 0.2 11.4 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) APG6 PF04111.7 ESA07614.1 - 0.15 11.0 12.7 0.27 10.2 8.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESA07614.1 - 0.17 9.7 8.4 0.23 9.2 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ax_dynein_light PF10211.4 ESA07614.1 - 0.28 11.0 13.0 0.42 10.4 9.0 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain DUF4140 PF13600.1 ESA07614.1 - 0.44 11.0 5.1 0.93 9.9 3.5 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) KfrA_N PF11740.3 ESA07614.1 - 0.55 10.6 5.6 0.89 10.0 3.9 1.2 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Atg14 PF10186.4 ESA07614.1 - 0.94 8.3 8.0 1.3 7.8 5.5 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Med21 PF11221.3 ESA07614.1 - 1.1 9.2 10.0 2.5 8.0 6.9 1.6 1 0 0 1 1 1 0 Subunit 21 of Mediator complex FbpA PF05833.6 ESA07614.1 - 1.9 6.9 16.5 2.7 6.4 11.4 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) IncA PF04156.9 ESA07614.1 - 2.2 7.8 12.3 3.8 7.0 8.5 1.3 1 0 0 1 1 1 0 IncA protein DUF3186 PF11382.3 ESA07614.1 - 4.7 6.2 4.8 7.3 5.6 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Pkinase_Tyr PF07714.12 ESA07615.1 - 1.3e-06 27.6 0.0 2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07615.1 - 0.0019 17.4 0.1 0.0039 16.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Toxin_31 PF08119.6 ESA07619.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Scorpion acidic alpha-KTx toxin family TaqI_C PF12950.2 ESA07622.1 - 0.036 13.8 0.7 0.039 13.6 0.5 1.0 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain C1-set PF07654.10 ESA07622.1 - 0.067 13.2 0.4 0.27 11.2 0.1 1.8 1 1 1 2 2 2 0 Immunoglobulin C1-set domain ApoA-II PF04711.8 ESA07622.1 - 0.083 12.7 0.3 0.63 9.9 0.1 2.0 1 1 1 2 2 2 0 Apolipoprotein A-II (ApoA-II) DUF4468 PF14730.1 ESA07625.1 - 0.011 15.4 0.8 0.036 13.7 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Tox-SGS PF15651.1 ESA07625.1 - 0.14 11.9 0.1 0.14 11.9 0.1 2.0 2 0 0 2 2 2 0 Salivary glad secreted protein domain toxin Flg_new PF09479.5 ESA07629.1 - 0.17 11.9 1.8 4.9 7.2 0.4 2.3 2 0 0 2 2 2 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Peptidase_C48 PF02902.14 ESA07632.1 - 3.3e-23 82.4 6.2 5.6e-21 75.1 4.3 2.3 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Sel1 PF08238.7 ESA07634.1 - 1.3e-10 41.5 2.4 5.3e-10 39.5 0.1 2.5 3 0 0 3 3 3 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA07634.1 - 0.0013 18.4 1.0 0.0013 18.4 0.7 1.6 2 0 0 2 2 2 1 zinc-ribbons Sulfate_transp PF00916.15 ESA07635.1 - 5.2e-69 232.3 10.6 9.9e-69 231.4 7.4 1.5 1 0 0 1 1 1 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 ESA07635.1 - 6.8e-30 102.5 4.8 6.8e-30 102.5 3.3 3.3 4 0 0 4 4 4 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 ESA07635.1 - 2.4e-15 55.9 0.0 4.4e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 ESA07635.1 - 0.016 15.1 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 STAS domain Na_H_antiport_2 PF13726.1 ESA07635.1 - 3.6 7.5 9.8 0.22 11.4 0.9 3.2 3 0 0 3 3 3 0 Na+-H+ antiporter family FAR1 PF03101.10 ESA07636.1 - 0.0048 17.3 0.3 0.0064 16.9 0.2 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain Pkinase_Tyr PF07714.12 ESA07637.1 - 1.5e-11 43.8 0.0 1.9e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07637.1 - 1.9e-10 40.3 0.2 6.7e-10 38.5 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain FAR1 PF03101.10 ESA07639.1 - 8.3e-07 29.4 1.2 1.3e-06 28.8 0.8 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA07639.1 - 0.026 14.1 0.0 0.053 13.0 0.0 1.5 1 0 0 1 1 1 0 MuDR family transposase HbrB PF08539.6 ESA07640.1 - 0.038 13.8 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 HbrB-like MtN3_slv PF03083.11 ESA07640.1 - 0.079 12.8 0.1 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange DivIC PF04977.10 ESA07642.1 - 0.0079 15.6 0.2 0.0079 15.6 0.1 2.2 2 0 0 2 2 2 1 Septum formation initiator DTHCT PF08070.6 ESA07642.1 - 0.058 14.0 2.0 0.09 13.4 1.4 1.3 1 0 0 1 1 1 0 DTHCT (NUC029) region TSC22 PF01166.13 ESA07642.1 - 0.058 13.3 0.6 0.058 13.3 0.4 2.1 2 1 0 2 2 2 0 TSC-22/dip/bun family DUF972 PF06156.8 ESA07642.1 - 9.1 6.6 10.3 2.3e+02 2.1 7.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Pkinase_Tyr PF07714.12 ESA07645.1 - 6.2e-39 133.6 0.0 9.2e-39 133.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07645.1 - 1.3e-37 129.3 0.7 2e-37 128.7 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain vWF_A PF12450.3 ESA07645.1 - 0.03 14.0 0.0 0.12 12.1 0.0 2.0 3 0 0 3 3 3 0 von Willebrand factor APH PF01636.18 ESA07645.1 - 0.075 12.7 0.0 0.29 10.8 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA07646.1 - 2.8e-05 23.3 0.1 6e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase TipAS PF07739.8 ESA07646.1 - 0.00087 19.6 0.0 0.0011 19.2 0.0 1.1 1 0 0 1 1 1 1 TipAS antibiotic-recognition domain Pkinase PF00069.20 ESA07646.1 - 0.0024 17.0 0.2 0.0057 15.8 0.0 1.6 1 1 1 2 2 2 1 Protein kinase domain DnaB_2 PF07261.6 ESA07646.1 - 0.0029 17.1 1.2 0.016 14.8 0.1 2.3 1 1 1 2 2 2 1 Replication initiation and membrane attachment Armet PF10208.4 ESA07646.1 - 0.0071 16.0 0.3 0.0097 15.5 0.2 1.3 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding MerR-DNA-bind PF09278.6 ESA07646.1 - 0.01 16.2 0.5 0.017 15.5 0.3 1.4 1 0 0 1 1 1 1 MerR, DNA binding DUF29 PF01724.11 ESA07646.1 - 0.016 15.0 1.0 0.02 14.7 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF29 DUF3080 PF11279.3 ESA07646.1 - 0.017 14.3 0.4 0.02 14.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Phage_GP20 PF06810.6 ESA07646.1 - 0.035 13.5 0.6 0.043 13.2 0.4 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 Paramyxo_PNT PF13825.1 ESA07646.1 - 0.05 12.8 1.2 0.058 12.5 0.8 1.0 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus VHS PF00790.14 ESA07646.1 - 0.057 13.0 1.1 0.43 10.2 0.2 2.2 1 1 0 2 2 2 0 VHS domain DUF3783 PF12646.2 ESA07646.1 - 0.086 12.5 0.5 3.3 7.5 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3783) BEX PF04538.7 ESA07646.1 - 0.13 12.5 1.0 0.21 11.8 0.5 1.4 1 1 0 1 1 1 0 Brain expressed X-linked like family Pkinase_Tyr PF07714.12 ESA07647.1 - 1.5e-24 86.4 0.0 2.5e-24 85.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07647.1 - 3.4e-23 82.1 0.2 6e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Dala_Dala_lig_C PF07478.8 ESA07648.1 - 0.0079 15.6 0.1 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus DUF1296 PF06972.6 ESA07648.1 - 0.027 14.4 1.0 3.3 7.7 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1296) Med31 PF05669.7 ESA07649.1 - 0.022 14.4 0.9 0.031 14.0 0.6 1.3 1 0 0 1 1 1 0 SOH1 IncA PF04156.9 ESA07651.1 - 0.00082 19.0 4.4 0.0012 18.4 3.0 1.2 1 0 0 1 1 1 1 IncA protein Ribosomal_L12 PF00542.14 ESA07651.1 - 0.0066 16.4 2.3 0.012 15.5 1.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain LRR_4 PF12799.2 ESA07651.1 - 0.0078 15.8 14.9 0.035 13.7 0.7 3.7 3 2 0 3 3 3 2 Leucine Rich repeats (2 copies) Macoilin PF09726.4 ESA07651.1 - 0.012 13.9 3.2 0.014 13.7 2.2 1.1 1 0 0 1 1 1 0 Transmembrane protein UBN2_3 PF14244.1 ESA07651.1 - 0.075 12.5 2.3 0.11 12.0 1.6 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type VHP PF02209.14 ESA07651.1 - 0.084 12.5 1.1 0.19 11.4 0.8 1.6 1 0 0 1 1 1 0 Villin headpiece domain DivIC PF04977.10 ESA07651.1 - 0.44 10.0 13.2 0.22 11.0 5.4 2.3 1 1 1 2 2 2 0 Septum formation initiator LRR_6 PF13516.1 ESA07651.1 - 3.2 8.0 6.2 21 5.5 0.1 3.9 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.1 ESA07651.1 - 3.6 7.3 7.1 7.8 6.3 0.9 2.9 2 1 0 3 3 3 0 Leucine rich repeat Pox_A_type_inc PF04508.7 ESA07651.1 - 4 7.4 12.8 2.7 7.9 0.3 3.1 2 1 1 3 3 3 0 Viral A-type inclusion protein repeat HSP70 PF00012.15 ESA07652.1 - 5.5e-30 103.8 0.1 6e-30 103.7 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Ion_trans PF00520.26 ESA07653.1 - 3.9e-08 32.7 14.3 6.1e-08 32.1 9.9 1.2 1 0 0 1 1 1 1 Ion transport protein Baculo_PEP_C PF04513.7 ESA07653.1 - 0.0016 18.2 6.3 0.0025 17.6 4.4 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus CagA PF03507.8 ESA07653.1 - 0.0027 17.6 1.8 0.004 17.0 1.2 1.2 1 0 0 1 1 1 1 CagA exotoxin LEA_4 PF02987.11 ESA07653.1 - 0.004 16.9 5.6 0.007 16.2 3.9 1.3 1 0 0 1 1 1 1 Late embryogenesis abundant protein Apolipoprotein PF01442.13 ESA07653.1 - 0.0059 16.1 1.9 0.0083 15.6 1.3 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF342 PF03961.8 ESA07653.1 - 0.061 11.7 9.8 0.075 11.4 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) YtxH PF12732.2 ESA07653.1 - 0.065 13.6 8.0 0.12 12.7 5.6 1.4 1 0 0 1 1 1 0 YtxH-like protein DUF883 PF05957.8 ESA07653.1 - 0.18 12.1 0.7 0.29 11.5 0.5 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Seryl_tRNA_N PF02403.17 ESA07653.1 - 0.41 10.6 13.0 0.63 10.0 9.0 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1043 PF06295.7 ESA07653.1 - 1.1 8.9 8.6 2.1 8.0 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Sds3 PF08598.6 ESA07653.1 - 1.1 8.7 10.0 1.7 8.1 6.9 1.2 1 0 0 1 1 1 0 Sds3-like DUF1664 PF07889.7 ESA07653.1 - 1.4 8.6 6.2 2.4 7.9 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PP2C PF00481.16 ESA07654.1 - 3.3e-10 39.7 2.4 1.7e-07 30.9 0.2 2.9 2 1 0 2 2 2 2 Protein phosphatase 2C Pentapeptide_4 PF13599.1 ESA07655.1 - 0.044 13.6 0.5 0.091 12.5 0.4 1.4 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) AdoMetDC_leader PF08132.6 ESA07657.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide AflR PF08493.5 ESA07658.1 - 1.1 8.2 4.1 1.1 8.1 2.8 1.0 1 0 0 1 1 1 0 Aflatoxin regulatory protein AAA_2 PF07724.9 ESA07659.1 - 3.3e-56 189.8 1.8 2.9e-51 173.7 0.0 3.5 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 ESA07659.1 - 2.1e-27 95.8 0.0 1.9e-14 54.0 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 ESA07659.1 - 1.3e-24 85.9 0.3 1.8e-23 82.2 0.0 3.2 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 ESA07659.1 - 5.6e-18 65.0 0.9 4.7e-11 42.5 0.0 3.6 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA07659.1 - 7.9e-15 55.3 8.5 1.2e-06 28.6 0.0 5.4 3 2 2 5 5 5 2 AAA ATPase domain Clp_N PF02861.15 ESA07659.1 - 7.9e-14 51.3 0.6 8.3e-08 32.0 0.1 3.3 2 0 0 2 2 2 2 Clp amino terminal domain AAA_22 PF13401.1 ESA07659.1 - 8e-11 42.2 0.8 0.00059 19.9 0.0 3.7 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.21 ESA07659.1 - 1.2e-08 34.5 0.1 3.6e-05 23.3 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.12 ESA07659.1 - 3.3e-08 33.1 0.0 0.015 14.7 0.0 3.5 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_14 PF13173.1 ESA07659.1 - 7.3e-08 32.3 1.7 0.0084 16.0 0.0 3.9 4 0 0 4 4 3 2 AAA domain AAA_17 PF13207.1 ESA07659.1 - 1.3e-06 29.2 12.1 0.002 18.9 0.0 4.3 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA07659.1 - 1.2e-05 25.5 9.1 0.021 15.1 0.0 3.8 4 1 0 4 4 2 2 AAA domain RNA_helicase PF00910.17 ESA07659.1 - 4.6e-05 23.5 0.0 0.27 11.4 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 ESA07659.1 - 5.2e-05 22.9 0.0 0.078 12.7 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain RuvB_N PF05496.7 ESA07659.1 - 6.2e-05 22.1 6.2 0.017 14.1 0.0 4.1 4 1 0 4 4 3 2 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 ESA07659.1 - 0.0001 21.4 3.7 0.00097 18.2 0.0 3.4 3 2 0 3 3 3 1 Zeta toxin NACHT PF05729.7 ESA07659.1 - 0.00014 21.5 0.0 0.074 12.7 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 ESA07659.1 - 0.00022 20.9 12.4 0.042 13.5 0.2 5.3 3 2 0 3 3 3 2 Archaeal ATPase AAA_28 PF13521.1 ESA07659.1 - 0.00031 20.7 0.2 1.6 8.6 0.0 3.6 3 1 0 3 3 3 1 AAA domain T2SE PF00437.15 ESA07659.1 - 0.00032 19.7 0.0 0.0024 16.8 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF258 PF03193.11 ESA07659.1 - 0.00091 18.4 0.0 1.2 8.2 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Mg_chelatase PF01078.16 ESA07659.1 - 0.0015 17.7 0.0 4.6 6.3 0.0 3.3 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 ESA07659.1 - 0.0019 17.6 1.3 0.16 11.3 0.0 3.4 3 1 0 4 4 4 1 AAA-like domain AAA_25 PF13481.1 ESA07659.1 - 0.002 17.5 2.4 1.3 8.3 0.0 3.8 4 0 0 4 4 4 1 AAA domain DNA_pol3_delta2 PF13177.1 ESA07659.1 - 0.0026 17.4 0.0 0.043 13.4 0.0 3.0 2 2 1 3 3 2 1 DNA polymerase III, delta subunit UPF0079 PF02367.12 ESA07659.1 - 0.0026 17.3 0.0 2.6 7.6 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_3 PF07726.6 ESA07659.1 - 0.0041 16.7 0.1 2.5 7.7 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Miro PF08477.8 ESA07659.1 - 0.0042 17.5 0.1 0.68 10.4 0.0 3.3 3 0 0 3 3 2 1 Miro-like protein AAA_33 PF13671.1 ESA07659.1 - 0.0048 16.7 0.0 0.53 10.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.12 ESA07659.1 - 0.0087 15.9 8.5 1 9.1 0.0 4.1 4 1 1 5 5 4 1 Domain of unknown function DUF87 MobB PF03205.9 ESA07659.1 - 0.011 15.4 0.0 2.8 7.6 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.10 ESA07659.1 - 0.013 15.2 1.8 0.3 10.9 0.0 3.6 3 2 0 4 4 2 0 Type III restriction enzyme, res subunit Torsin PF06309.6 ESA07659.1 - 0.017 14.9 0.0 0.092 12.6 0.0 2.1 2 0 0 2 2 2 0 Torsin AAA_29 PF13555.1 ESA07659.1 - 0.021 14.3 0.0 5.2 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 ESA07659.1 - 0.024 14.3 0.1 6.4 6.4 0.0 3.3 3 0 0 3 3 3 0 NTPase PduV-EutP PF10662.4 ESA07659.1 - 0.03 13.7 0.0 2 7.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 ESA07659.1 - 0.037 13.4 0.0 6.4 6.1 0.0 2.9 2 0 0 2 2 2 0 Ras family SRP54 PF00448.17 ESA07659.1 - 0.061 12.7 1.3 13 5.2 0.0 3.6 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 ESA07659.1 - 0.18 12.1 8.9 1.5 9.0 0.0 4.5 4 1 0 4 4 3 0 ABC transporter FlxA PF14282.1 ESA07659.1 - 0.6 10.0 8.3 0.15 12.0 1.2 2.5 2 0 0 2 2 2 0 FlxA-like protein AAA_23 PF13476.1 ESA07659.1 - 2 8.6 0.0 2 8.6 0.0 4.4 3 1 0 3 3 1 0 AAA domain V_ATPase_I PF01496.14 ESA07659.1 - 2.9 5.6 6.9 5.2 4.8 4.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.4 ESA07659.1 - 9.4 5.0 13.5 18 4.1 9.3 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF2985 PF11204.3 ESA07660.1 - 1.5e-11 43.8 4.0 1.5e-11 43.8 2.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) DUF4405 PF14358.1 ESA07660.1 - 0.014 15.4 0.6 0.014 15.4 0.4 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) CTP_transf_1 PF01148.15 ESA07660.1 - 0.039 13.6 8.4 0.05 13.2 5.8 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family PepSY_TM_1 PF13172.1 ESA07660.1 - 0.13 12.0 6.2 0.54 10.0 4.3 2.2 1 0 0 1 1 1 0 PepSY-associated TM helix VIT1 PF01988.14 ESA07660.1 - 0.49 9.8 3.7 2.8 7.3 0.9 2.2 2 0 0 2 2 2 0 VIT family Maelstrom PF13017.1 ESA07661.1 - 0.0085 15.5 1.0 0.46 9.9 0.1 2.1 1 1 1 2 2 2 2 piRNA pathway germ-plasm component AlaDh_PNT_N PF05222.10 ESA07662.1 - 6e-29 100.7 0.0 9.5e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 ESA07662.1 - 2.4e-15 56.4 0.0 7.5e-15 54.8 0.0 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain MMR_HSR1 PF01926.18 ESA07664.1 - 6.4e-05 22.8 0.2 0.00011 22.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA07664.1 - 0.00015 22.5 0.2 0.00031 21.5 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA07664.1 - 0.00052 20.3 0.7 0.0011 19.3 0.4 1.7 2 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 ESA07664.1 - 0.0026 17.2 0.6 0.0044 16.5 0.4 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 ESA07664.1 - 0.0089 16.3 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 ABC transporter Flagellin_D3 PF08884.6 ESA07664.1 - 0.043 14.0 0.4 0.071 13.2 0.3 1.3 1 0 0 1 1 1 0 Flagellin D3 domain AAA_21 PF13304.1 ESA07664.1 - 0.048 13.6 0.1 0.068 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESA07664.1 - 0.051 13.1 0.2 0.09 12.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.11 ESA07664.1 - 0.054 12.5 2.1 0.31 10.0 0.4 2.1 1 1 1 2 2 2 0 AIG1 family MobB PF03205.9 ESA07664.1 - 0.071 12.8 1.5 0.11 12.1 0.7 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 ESA07664.1 - 0.086 11.7 0.3 0.11 11.3 0.2 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.15 ESA07664.1 - 0.12 10.9 0.3 0.2 10.3 0.2 1.4 1 1 0 1 1 1 0 G-protein alpha subunit Ribosomal_L4 PF00573.17 ESA07667.1 - 2.5e-28 98.7 0.1 4.1e-28 98.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 ESA07667.1 - 1.4e-26 92.1 1.1 1.4e-26 92.1 0.7 2.0 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Nop14 PF04147.7 ESA07668.1 - 1.7e-109 367.0 41.3 2e-109 366.7 28.7 1.0 1 0 0 1 1 1 1 Nop14-like family Pet127 PF08634.5 ESA07669.1 - 0.044 12.9 0.5 0.063 12.4 0.3 1.3 1 1 0 1 1 1 0 Mitochondrial protein Pet127 CHD5 PF04420.9 ESA07670.1 - 0.00083 19.0 4.7 0.00083 19.0 3.3 2.3 1 1 0 2 2 2 1 CHD5-like protein zf-C2H2 PF00096.21 ESA07670.1 - 0.0024 18.1 1.3 0.0048 17.1 0.9 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type DUF2924 PF11149.3 ESA07670.1 - 1.7 8.6 4.5 0.69 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) CCDC-167 PF15188.1 ESA07670.1 - 3.7 7.5 12.8 0.36 10.7 1.5 2.9 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 FlaC_arch PF05377.6 ESA07670.1 - 4.2 7.3 15.0 0.14 12.0 1.4 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TIR_2 PF13676.1 ESA07671.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 TIR domain Pkinase PF00069.20 ESA07672.1 - 3.6e-27 95.1 0.0 4.4e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07672.1 - 1.5e-25 89.7 0.0 3.2e-25 88.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA07672.1 - 0.00097 18.2 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA07672.1 - 0.0053 16.0 0.0 0.008 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA07672.1 - 0.051 12.9 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Toprim_N PF08275.6 ESA07672.1 - 0.13 12.2 0.2 0.28 11.1 0.1 1.6 1 1 0 1 1 1 0 DNA primase catalytic core, N-terminal domain APH PF01636.18 ESA07672.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA07673.1 - 2.8e-05 23.4 0.3 3.2e-05 23.1 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07673.1 - 0.031 13.3 0.1 0.036 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase HSDR_N_2 PF13588.1 ESA07674.1 - 0.007 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) DUF4116 PF13475.1 ESA07675.1 - 0.052 13.0 0.9 0.097 12.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) MMR_HSR1 PF01926.18 ESA07676.1 - 2.3e-06 27.5 0.2 7.1e-06 25.9 0.2 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA07676.1 - 0.00032 19.8 7.5 0.004 16.2 2.1 3.0 2 1 0 2 2 2 1 AIG1 family DUF258 PF03193.11 ESA07676.1 - 0.00068 18.8 0.2 0.0027 16.9 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_28 PF13521.1 ESA07676.1 - 0.00088 19.2 0.1 0.0055 16.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 ESA07676.1 - 0.0015 18.0 0.0 0.0044 16.4 0.0 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Dynamin_N PF00350.18 ESA07676.1 - 0.0037 17.0 1.8 2.1 8.1 0.0 3.2 3 0 0 3 3 3 1 Dynamin family ABC_tran PF00005.22 ESA07676.1 - 0.0046 17.2 0.1 0.015 15.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter DUF815 PF05673.8 ESA07676.1 - 0.0075 15.2 0.3 0.032 13.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) T2SE PF00437.15 ESA07676.1 - 0.01 14.7 1.5 0.017 14.0 0.0 2.1 3 0 0 3 3 3 0 Type II/IV secretion system protein GBP PF02263.14 ESA07676.1 - 0.011 14.8 0.2 0.053 12.5 0.0 1.9 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain AAA PF00004.24 ESA07676.1 - 0.012 15.8 0.2 0.036 14.2 0.1 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ESA07676.1 - 0.012 15.1 0.1 0.028 13.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 ESA07676.1 - 0.03 14.0 0.1 0.085 12.6 0.0 1.7 2 0 0 2 2 2 0 Part of AAA domain Viral_helicase1 PF01443.13 ESA07676.1 - 0.044 13.2 0.6 5.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 ESA07676.1 - 0.064 13.5 0.5 0.064 13.5 0.3 3.2 1 1 0 2 2 1 0 AAA domain Miro PF08477.8 ESA07676.1 - 0.073 13.5 0.5 0.3 11.6 0.0 2.3 2 2 1 3 3 2 0 Miro-like protein FtsK_SpoIIIE PF01580.13 ESA07676.1 - 0.11 12.0 0.1 0.22 10.9 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.12 ESA07676.1 - 0.89 9.3 6.4 0.66 9.7 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF87 AAA PF00004.24 ESA07677.1 - 0.00023 21.3 0.5 0.002 18.3 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Miro PF08477.8 ESA07677.1 - 0.00038 20.9 0.0 0.0014 19.0 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_5 PF07728.9 ESA07677.1 - 0.00046 19.9 0.0 0.0012 18.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESA07677.1 - 0.00068 19.7 0.0 0.0041 17.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA07677.1 - 0.0026 17.9 0.2 0.016 15.3 0.1 2.3 1 1 0 1 1 1 1 RNA helicase NACHT PF05729.7 ESA07677.1 - 0.005 16.5 0.0 0.077 12.6 0.0 2.6 3 0 0 3 3 3 1 NACHT domain AAA_14 PF13173.1 ESA07677.1 - 0.021 14.7 0.0 0.074 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA07677.1 - 0.024 14.9 0.0 0.091 13.0 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Sigma54_activ_2 PF14532.1 ESA07677.1 - 0.071 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SE PF00437.15 ESA07677.1 - 0.076 11.9 0.0 0.15 10.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 ESA07677.1 - 0.097 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESA07677.1 - 0.11 13.3 0.0 0.53 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 ESA07677.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Pkinase PF00069.20 ESA07678.1 - 2.9e-16 59.3 1.2 1e-15 57.6 0.8 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07678.1 - 3.9e-16 58.9 0.0 6e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-RING_4 PF14570.1 ESA07678.1 - 0.026 14.1 3.3 0.026 14.1 2.3 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.1 ESA07679.1 - 1.1e-08 34.9 9.0 2e-08 34.1 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA07679.1 - 1.9e-08 34.0 8.0 3.6e-08 33.0 5.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA07679.1 - 2.3e-07 30.3 9.7 4.1e-07 29.5 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA07679.1 - 4.4e-07 29.4 5.4 7.4e-07 28.7 3.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA07679.1 - 3.3e-06 26.7 7.5 6.3e-06 25.8 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 ESA07679.1 - 1.7e-05 24.6 5.7 4.9e-05 23.1 4.1 1.8 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA07679.1 - 2.3e-05 24.0 5.7 5.5e-05 22.7 3.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger FYVE PF01363.16 ESA07679.1 - 0.0098 15.7 1.8 0.022 14.6 1.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger MoaF PF10703.4 ESA07679.1 - 0.029 13.4 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Molybdenum cofactor biosynthesis protein F zf-MIZ PF02891.15 ESA07679.1 - 0.029 13.8 9.3 0.068 12.6 6.5 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Nse PF11789.3 ESA07679.1 - 0.73 9.3 7.8 0.61 9.6 3.9 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.2 ESA07679.1 - 8.8 6.5 10.6 0.35 10.9 3.1 1.9 2 0 0 2 2 1 0 RING-H2 zinc finger PEX11 PF05648.9 ESA07680.1 - 1.2e-25 90.1 0.0 1.4e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sel1 PF08238.7 ESA07682.1 - 5.2e-80 262.1 32.8 1.6e-12 47.6 0.6 8.0 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA07682.1 - 7.8e-13 47.9 14.3 0.082 13.4 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA07682.1 - 3.8e-06 27.4 3.4 0.88 10.3 0.0 5.7 3 2 5 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07682.1 - 1.4e-05 24.6 32.1 0.17 11.5 2.7 6.9 1 1 6 7 7 7 3 TPR repeat TPR_14 PF13428.1 ESA07682.1 - 3.4e-05 24.1 0.1 29 5.6 0.0 5.2 5 2 1 6 6 5 0 Tetratricopeptide repeat DUF4227 PF14004.1 ESA07682.1 - 0.015 15.1 0.6 22 4.9 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF4227) Fucose_iso_N2 PF07882.7 ESA07682.1 - 0.023 14.3 12.2 0.34 10.5 0.1 3.6 2 2 2 4 4 4 0 L-fucose isomerase, second N-terminal domain Apc3 PF12895.2 ESA07682.1 - 0.045 13.8 16.1 5.9 7.1 3.1 4.3 3 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA07682.1 - 0.049 13.9 13.7 12 6.2 0.3 5.8 6 1 1 7 7 6 0 Tetratricopeptide repeat Luciferase_N PF05295.6 ESA07682.1 - 0.087 12.6 0.1 16 5.3 0.0 2.6 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain TPR_17 PF13431.1 ESA07682.1 - 0.09 13.0 23.1 21 5.6 0.0 8.8 4 2 6 10 10 10 0 Tetratricopeptide repeat DMA PF03474.9 ESA07682.1 - 0.11 12.3 0.0 18 5.3 0.0 2.3 2 0 0 2 2 2 0 DMRTA motif TOM20_plant PF06552.7 ESA07682.1 - 0.15 11.6 2.5 14 5.1 0.1 3.7 2 2 2 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 MIT PF04212.13 ESA07682.1 - 0.73 9.7 15.9 14 5.6 0.1 5.7 6 1 0 6 6 5 0 MIT (microtubule interacting and transport) domain BTB PF00651.26 ESA07683.1 - 1.6e-18 66.7 0.2 1.8e-17 63.3 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA07683.1 - 6.6e-14 52.0 6.3 1.1e-13 51.3 4.4 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA07683.1 - 2.9e-07 30.2 0.2 3.3e-06 26.8 0.0 2.6 2 1 0 2 2 2 1 BTB And C-terminal Kelch Acyl-CoA_ox_N PF14749.1 ESA07685.1 - 4.3e-11 43.1 0.1 5.1e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Pyr_redox PF00070.22 ESA07688.1 - 3.4e-17 62.6 0.2 5e-12 46.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 ESA07688.1 - 1.6e-16 60.8 3.6 1.5e-08 34.7 0.2 3.8 1 1 2 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESA07688.1 - 4.3e-07 30.2 0.1 0.00056 20.0 0.0 2.9 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ESA07688.1 - 8.2e-07 28.2 0.2 0.00058 18.8 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 ESA07688.1 - 3.8e-06 25.8 0.9 0.003 16.2 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase DAO PF01266.19 ESA07688.1 - 8e-06 24.9 0.5 0.045 12.6 0.1 3.9 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 ESA07688.1 - 6.8e-05 22.6 1.8 0.034 13.9 0.0 3.4 3 1 1 4 4 4 1 FAD-NAD(P)-binding TrkA_N PF02254.13 ESA07688.1 - 0.00035 20.5 0.6 0.26 11.3 0.0 2.7 2 0 0 2 2 2 2 TrkA-N domain NAD_binding_7 PF13241.1 ESA07688.1 - 0.0013 18.9 0.2 0.69 10.1 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.1 ESA07688.1 - 0.0017 18.3 0.2 0.095 12.7 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 ESA07688.1 - 0.0024 16.8 0.1 3.1 6.6 0.0 3.3 3 1 1 4 4 4 2 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.18 ESA07688.1 - 0.097 12.3 0.3 2.8 7.6 0.0 2.5 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 ESA07688.1 - 0.13 12.7 3.6 9.1 6.7 0.1 3.3 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent FAD_binding_3 PF01494.14 ESA07688.1 - 0.3 10.0 2.6 5.9 5.8 0.6 2.2 2 0 0 2 2 2 0 FAD binding domain BTB PF00651.26 ESA07690.1 - 6.5e-16 58.3 0.1 1.1e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA07690.1 - 7.4e-12 45.4 1.6 8.4e-12 45.2 0.3 1.7 2 0 0 2 2 2 1 TLD Urm1 PF09138.6 ESA07690.1 - 0.03 14.4 0.2 0.42 10.7 0.1 2.4 2 0 0 2 2 2 0 Urm1 (Ubiquitin related modifier) BACK PF07707.10 ESA07690.1 - 0.033 14.0 2.5 1.9 8.3 0.2 3.4 1 1 3 4 4 4 0 BTB And C-terminal Kelch HMG_box PF00505.14 ESA07691.1 - 5.1e-10 39.4 0.1 6.3e-10 39.1 0.1 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07691.1 - 0.017 15.4 0.1 0.024 15.0 0.0 1.2 1 0 0 1 1 1 0 HMG-box domain PRESAN PF09687.5 ESA07691.1 - 0.058 13.4 0.1 0.062 13.3 0.1 1.2 1 0 0 1 1 1 0 Plasmodium RESA N-terminal NAD_binding_1 PF00175.16 ESA07692.1 - 4.3e-15 56.2 0.0 9.8e-15 55.0 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA07692.1 - 2.1e-08 34.2 0.0 7.4e-07 29.1 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 ESA07692.1 - 1.1e-06 28.6 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain DUF633 PF04816.7 ESA07692.1 - 0.12 11.7 0.0 1.9 7.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF633) adh_short PF00106.20 ESA07693.1 - 5.6e-15 55.6 0.0 7.4e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA07693.1 - 6.3e-07 29.2 0.0 8e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESA07693.1 - 0.00014 21.3 0.1 0.00021 20.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESA07693.1 - 0.00019 21.2 0.0 0.00027 20.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.7 ESA07693.1 - 0.0002 20.3 0.4 0.00026 20.0 0.3 1.1 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 ESA07693.1 - 0.00025 21.1 0.0 0.00033 20.7 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding ApbA PF02558.11 ESA07693.1 - 0.027 13.9 0.1 0.041 13.3 0.0 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.14 ESA07693.1 - 0.03 13.3 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain UDPGT PF00201.13 ESA07693.1 - 0.094 11.2 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Ribosomal_L36 PF00444.13 ESA07696.1 - 0.14 12.1 2.1 0.34 10.9 1.5 1.6 1 0 0 1 1 1 0 Ribosomal protein L36 TSC22 PF01166.13 ESA07697.1 - 0.0027 17.6 3.3 0.0027 17.6 2.3 2.7 1 1 2 3 3 3 1 TSC-22/dip/bun family CENP-Q PF13094.1 ESA07697.1 - 0.0088 16.0 10.6 0.012 15.5 7.3 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Microtub_assoc PF07989.6 ESA07697.1 - 0.063 13.1 11.3 0.11 12.3 1.4 2.3 1 1 0 2 2 2 0 Microtubule associated Complex1_LYR_2 PF13233.1 ESA07697.1 - 0.099 13.1 4.0 0.18 12.2 2.8 1.5 1 1 0 1 1 1 0 Complex1_LYR-like DUF972 PF06156.8 ESA07697.1 - 0.2 12.0 13.2 0.072 13.4 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2547 PF10818.3 ESA07697.1 - 1.2 9.7 7.3 0.4 11.3 2.9 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF2547) bZIP_1 PF00170.16 ESA07697.1 - 1.8 8.5 9.2 0.87 9.5 2.1 2.8 1 1 1 3 3 3 0 bZIP transcription factor Kinetocho_Slk19 PF12709.2 ESA07697.1 - 3.7 7.7 10.1 3.3 7.8 1.3 2.5 1 1 2 3 3 3 0 Central kinetochore-associated DUF342 PF03961.8 ESA07697.1 - 5.1 5.3 8.4 5.3 5.3 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ATG22 PF11700.3 ESA07698.1 - 6.5e-121 404.1 20.3 7.6e-121 403.8 14.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 ESA07698.1 - 4.4e-07 28.9 34.8 7.9e-05 21.5 6.1 4.0 2 1 2 4 4 4 3 Major Facilitator Superfamily Pkinase_Tyr PF07714.12 ESA07700.1 - 0.0032 16.5 0.0 0.27 10.2 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA07700.1 - 0.004 16.3 0.0 0.94 8.5 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain AAA_12 PF13087.1 ESA07701.1 - 7.8e-39 133.1 0.0 1.1e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA07701.1 - 1.8e-15 57.1 0.2 3.5e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 ESA07701.1 - 0.05 13.1 0.0 1.2 8.5 0.0 2.4 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase IPT PF01745.11 ESA07701.1 - 0.099 11.8 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 Isopentenyl transferase UvrD_C_2 PF13538.1 ESA07701.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_30 PF13604.1 ESA07701.1 - 0.25 10.9 0.5 1.8 8.1 0.0 2.4 2 1 1 3 3 3 0 AAA domain Sel1 PF08238.7 ESA07702.1 - 4.2e-47 157.5 7.2 3.6e-10 40.1 0.0 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_12 PF13424.1 ESA07702.1 - 0.55 10.1 8.1 6 6.8 0.0 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA07702.1 - 9.4 6.2 11.0 5.6 6.9 0.4 3.8 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain DUF4618 PF15397.1 ESA07703.1 - 0.021 14.1 1.2 0.023 14.0 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) FAD_binding_3 PF01494.14 ESA07704.1 - 1.2e-11 44.2 0.0 1.6e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain F-box-like PF12937.2 ESA07705.1 - 6.2e-05 22.6 2.9 0.00025 20.6 1.3 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA07705.1 - 0.57 9.9 10.0 0.7 9.6 2.2 4.2 4 1 0 4 4 4 0 F-box domain FAD_binding_3 PF01494.14 ESA07706.1 - 1.2e-06 27.8 0.0 3.3e-06 26.3 0.0 1.6 1 1 1 2 2 2 1 FAD binding domain BACK PF07707.10 ESA07707.1 - 1.3e-08 34.5 1.6 3.9e-08 33.0 0.3 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA07707.1 - 1.3e-06 28.4 0.7 5.6e-05 23.0 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain Tenui_NS4 PF03300.8 ESA07707.1 - 0.027 13.5 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Tenuivirus non-structural protein NS4 BTB_2 PF02214.17 ESA07707.1 - 0.13 12.4 0.7 4.4 7.5 0.0 2.8 1 1 2 3 3 3 0 BTB/POZ domain DUF262 PF03235.9 ESA07708.1 - 0.013 15.4 0.2 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF1885 PF08968.5 ESA07708.1 - 0.072 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1885) MCM_N PF14551.1 ESA07709.1 - 1.1 9.7 10.9 0.22 12.0 4.4 2.1 1 1 0 2 2 2 0 MCM N-terminal domain TLD PF07534.11 ESA07710.1 - 6.2e-15 55.4 2.3 9.8e-15 54.7 1.6 1.3 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA07710.1 - 0.00075 19.3 0.0 0.0041 16.9 0.0 2.2 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF3942 PF13078.1 ESA07710.1 - 0.0017 18.4 0.6 0.004 17.2 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3942) BTB PF00651.26 ESA07711.1 - 3.2e-18 65.7 0.0 3.7e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA07711.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain MinE PF03776.9 ESA07711.1 - 0.073 12.5 0.3 2.1 7.8 0.0 2.2 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE DUF3342 PF11822.3 ESA07711.1 - 0.11 11.5 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF2116 PF09889.4 ESA07712.1 - 0.4 10.5 2.9 0.25 11.1 0.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Tenui_PVC2 PF06656.6 ESA07712.1 - 0.56 7.9 3.5 0.58 7.8 2.4 1.0 1 0 0 1 1 1 0 Tenuivirus PVC2 protein Kelch_6 PF13964.1 ESA07714.1 - 2.6e-05 24.1 6.2 2.3 8.5 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA07714.1 - 0.004 16.9 15.3 0.0093 15.7 0.0 4.6 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA07714.1 - 0.0061 16.0 11.5 0.37 10.3 0.3 4.5 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA07714.1 - 0.22 11.7 8.2 12 6.1 0.0 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Velvet PF11754.3 ESA07719.1 - 1.9e-05 24.3 0.1 4.8e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Velvet factor RIX1 PF08167.7 ESA07720.1 - 0.0039 16.8 6.5 1.3 8.7 0.3 3.9 4 0 0 4 4 4 2 rRNA processing/ribosome biogenesis Pkinase PF00069.20 ESA07721.1 - 3.4e-11 42.8 1.5 8.9e-06 25.0 0.1 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07721.1 - 1.7e-09 37.1 0.0 0.00019 20.6 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA07721.1 - 0.11 12.1 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Iso_dh PF00180.15 ESA07724.1 - 2e-98 329.5 0.0 7e-98 327.7 0.0 1.7 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase KLRAQ PF10205.4 ESA07725.1 - 3e-18 65.7 3.8 4.1e-18 65.3 2.6 1.2 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Dor1 PF04124.7 ESA07725.1 - 0.0015 17.0 3.0 0.0018 16.7 2.1 1.0 1 0 0 1 1 1 1 Dor1-like family BLOC1_2 PF10046.4 ESA07725.1 - 0.011 15.8 1.6 0.74 9.9 0.1 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3584 PF12128.3 ESA07725.1 - 0.015 12.6 7.0 0.018 12.3 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TBPIP PF07106.8 ESA07725.1 - 0.025 14.1 2.1 0.033 13.7 1.5 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF2968 PF11180.3 ESA07725.1 - 0.027 13.8 5.7 0.033 13.5 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF641 PF04859.7 ESA07725.1 - 0.036 13.8 4.0 0.047 13.4 2.8 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) IncA PF04156.9 ESA07725.1 - 0.037 13.6 7.2 0.052 13.1 5.0 1.2 1 0 0 1 1 1 0 IncA protein ADIP PF11559.3 ESA07725.1 - 0.073 12.9 10.1 0.13 12.1 7.0 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.2 ESA07725.1 - 0.093 12.5 6.2 0.14 12.0 4.3 1.2 1 0 0 1 1 1 0 Tropomyosin like FlgN PF05130.7 ESA07725.1 - 0.098 12.9 5.5 0.15 12.3 3.8 1.3 1 1 0 1 1 1 0 FlgN protein DUF1192 PF06698.6 ESA07725.1 - 0.11 12.2 1.9 2.4 8.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF3752 PF12572.3 ESA07725.1 - 0.12 12.5 2.6 0.14 12.3 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) Sigma70_ner PF04546.8 ESA07725.1 - 0.17 11.4 2.7 0.21 11.1 1.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Peptidase_S49_N PF08496.5 ESA07725.1 - 0.18 11.5 3.5 0.21 11.3 2.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OmpH PF03938.9 ESA07725.1 - 0.21 11.5 7.5 0.37 10.7 5.2 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TACC PF05010.9 ESA07725.1 - 0.25 11.1 5.9 0.26 11.0 3.4 1.5 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) TPR_MLP1_2 PF07926.7 ESA07725.1 - 0.25 11.0 7.9 0.32 10.7 5.5 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESA07725.1 - 0.27 10.1 5.6 0.3 9.9 3.9 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 ESA07725.1 - 0.28 9.5 3.1 0.3 9.4 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SYCE1 PF15233.1 ESA07725.1 - 0.46 10.4 8.3 4.9 7.0 6.0 1.9 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 DUF4140 PF13600.1 ESA07725.1 - 0.47 10.9 4.7 3.4 8.1 1.1 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.10 ESA07725.1 - 0.68 9.4 7.5 1.2 8.6 1.3 2.2 1 1 1 2 2 2 0 Septum formation initiator DUF3450 PF11932.3 ESA07725.1 - 1.5 8.0 7.3 2.8 7.1 1.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF465 PF04325.8 ESA07725.1 - 1.6 8.5 5.8 5 6.9 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF465) DUF972 PF06156.8 ESA07725.1 - 1.6 9.0 5.6 5 7.5 3.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Mito_carr PF00153.22 ESA07726.1 - 1.4e-59 197.8 1.9 1.1e-21 76.3 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein zf-DHHC PF01529.15 ESA07727.1 - 5.1e-29 100.8 16.7 5.1e-29 100.8 11.6 2.3 1 1 0 2 2 2 1 DHHC palmitoyltransferase DUF3139 PF11337.3 ESA07727.1 - 0.23 11.7 0.0 0.23 11.7 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) PBP1_TM PF14812.1 ESA07727.1 - 1.1 9.5 5.7 2.6 8.4 0.0 3.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L27 PF01016.14 ESA07728.1 - 6.8e-19 67.4 0.1 8.9e-19 67.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein MACPF PF01823.14 ESA07729.1 - 2.1e-07 30.8 1.0 2.1e-07 30.8 0.7 2.1 3 0 0 3 3 3 1 MAC/Perforin domain ubiquitin PF00240.18 ESA07731.1 - 0.055 12.8 0.1 0.25 10.7 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin family DUF3990 PF13151.1 ESA07733.1 - 0.0015 17.9 0.0 0.0033 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) CobD_Cbib PF03186.8 ESA07734.1 - 0.028 13.4 0.2 0.042 12.9 0.1 1.2 1 0 0 1 1 1 0 CobD/Cbib protein HPD PF05044.7 ESA07736.1 - 0.0085 15.7 7.5 0.2 11.3 0.8 2.1 1 1 1 2 2 2 2 Homeo-prospero domain Involucrin_N PF10583.4 ESA07736.1 - 0.2 11.9 3.0 5.4 7.3 0.2 2.3 2 0 0 2 2 2 0 Involucrin of squamous epithelia N-terminus Basic PF01586.11 ESA07736.1 - 9.3 7.0 10.8 12 6.6 5.0 2.0 1 1 1 2 2 2 0 Myogenic Basic domain HRDC PF00570.18 ESA07738.1 - 1.1e-16 60.3 0.0 2e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 HRDC domain Pkinase_Tyr PF07714.12 ESA07739.1 - 2.6e-08 33.2 0.0 4.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07739.1 - 9.4e-07 28.2 0.1 2.5e-06 26.8 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Integrin_B_tail PF07965.7 ESA07739.1 - 0.69 10.3 13.3 2.6 8.5 1.4 2.4 1 1 1 2 2 2 0 Integrin beta tail domain Cript PF10235.4 ESA07739.1 - 3.4 8.0 14.0 13 6.1 7.7 2.3 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT IF3_N PF05198.11 ESA07741.1 - 0.00023 21.0 16.4 1.3 9.0 0.2 6.4 1 1 4 6 6 6 4 Translation initiation factor IF-3, N-terminal domain DUF3303 PF11746.3 ESA07741.1 - 0.47 10.8 2.9 19 5.7 0.1 2.8 1 1 0 3 3 3 0 Protein of unknown function (DUF3303) RST PF12174.3 ESA07741.1 - 1.5 8.7 7.1 0.73 9.6 1.2 2.8 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Pox_F11 PF04943.7 ESA07741.1 - 3.9 6.2 15.4 1.2 7.8 2.2 2.2 1 1 1 2 2 2 0 Poxvirus F11 protein Condensin2nSMC PF12422.3 ESA07741.1 - 6.7 6.4 17.5 0.91 9.2 0.4 3.2 1 1 2 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit Sec20 PF03908.8 ESA07741.1 - 9.6 5.9 9.6 0.49 10.1 1.2 2.9 2 1 1 3 3 3 0 Sec20 Pkinase_Tyr PF07714.12 ESA07742.1 - 5e-49 166.7 0.0 9.5e-49 165.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07742.1 - 2.1e-43 148.3 0.0 4.4e-43 147.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain ABC_membrane PF00664.18 ESA07743.1 - 2.1e-29 102.7 9.5 2.5e-29 102.5 6.6 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF2628 PF10947.3 ESA07743.1 - 0.1 12.4 2.7 0.76 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) PufQ PF05398.6 ESA07743.1 - 0.88 9.6 3.8 3.8 7.6 0.4 2.3 2 0 0 2 2 2 0 PufQ cytochrome subunit DUF1230 PF06799.6 ESA07743.1 - 1.1 9.1 4.7 9.3 6.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1230) zf-DHHC PF01529.15 ESA07743.1 - 8.9 5.6 6.4 12 5.2 4.5 1.3 1 1 0 1 1 1 0 DHHC palmitoyltransferase Pkinase_Tyr PF07714.12 ESA07744.1 - 3.4e-33 114.8 0.0 4.3e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07744.1 - 1.2e-26 93.4 0.0 1.7e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain NosD PF05048.8 ESA07745.1 - 2.9e-09 36.4 7.8 2.9e-09 36.4 5.4 2.3 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) TPR_3 PF07720.7 ESA07747.1 - 0.12 12.1 0.8 0.38 10.6 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ubiquitin PF00240.18 ESA07748.1 - 3.8e-34 115.9 1.2 5.7e-34 115.3 0.9 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA07748.1 - 9.7e-20 70.0 0.9 1.7e-19 69.2 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.11 ESA07748.1 - 2.9e-08 33.4 15.8 4.4e-08 32.8 11.0 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.1 ESA07748.1 - 1.1e-05 25.5 0.3 4.3e-05 23.6 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ESA07748.1 - 7.2e-05 22.5 0.1 0.00014 21.5 0.0 1.5 2 0 0 2 2 2 1 Telomere stability and silencing DUF2407 PF10302.4 ESA07748.1 - 0.0064 16.6 0.1 0.0073 16.4 0.1 1.3 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA07748.1 - 0.014 15.3 0.6 0.032 14.1 0.1 1.9 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Plexin_cytopl PF08337.7 ESA07748.1 - 0.11 10.7 0.5 1.4 7.1 0.1 2.0 2 0 0 2 2 2 0 Plexin cytoplasmic RasGAP domain Pkinase_Tyr PF07714.12 ESA07749.1 - 4.6e-49 166.8 0.0 7.7e-49 166.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07749.1 - 5.2e-43 147.0 0.4 8.8e-43 146.3 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07749.1 - 0.0006 18.9 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2306 PF10067.4 ESA07750.1 - 0.034 14.2 1.3 0.034 14.2 0.9 2.9 2 2 0 2 2 2 0 Predicted membrane protein (DUF2306) DUF2910 PF11139.3 ESA07750.1 - 0.04 13.0 0.9 0.14 11.2 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2910) MAT_Alpha1 PF04769.7 ESA07751.1 - 0.074 12.3 1.3 0.08 12.2 0.9 1.1 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 MBOAT_2 PF13813.1 ESA07754.1 - 2.6e-10 40.2 2.4 2.6e-10 40.2 1.6 2.1 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family DUF3688 PF12461.3 ESA07754.1 - 4.5 7.7 6.1 1.8 9.0 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3688) DUF3769 PF12600.3 ESA07755.1 - 0.061 12.1 0.1 0.065 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) Atg31 PF09795.4 ESA07755.1 - 0.065 12.9 0.3 0.061 13.0 0.2 1.1 1 0 0 1 1 1 0 Autophagy-related protein 31 DUF3622 PF12286.3 ESA07756.1 - 0.046 14.0 0.2 0.057 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3622) DUF1894 PF08979.6 ESA07758.1 - 0.086 12.9 0.2 0.15 12.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1894) HMG_box PF00505.14 ESA07760.1 - 9.9e-17 60.9 4.0 1.2e-16 60.7 2.8 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07760.1 - 5.7e-05 23.4 2.0 7.4e-05 23.0 1.4 1.2 1 0 0 1 1 1 1 HMG-box domain PRTase_2 PF15609.1 ESA07760.1 - 0.048 12.9 0.0 0.053 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosphoribosyl transferase DUF2950 PF11453.3 ESA07760.1 - 0.063 12.2 1.1 0.065 12.2 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) MAT_Alpha1 PF04769.7 ESA07760.1 - 0.1 11.8 0.2 0.31 10.3 0.0 1.6 1 1 1 2 2 2 0 Mating-type protein MAT alpha 1 Transposase_21 PF02992.9 ESA07761.1 - 4.7e-12 45.4 0.1 5.8e-12 45.1 0.1 1.1 1 0 0 1 1 1 1 Transposase family tnp2 DDE_3 PF13358.1 ESA07763.1 - 4e-08 33.1 0.0 1.9e-05 24.4 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease His_Phos_1 PF00300.17 ESA07764.1 - 9.9e-22 77.7 0.7 1.1e-21 77.6 0.5 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 ESA07764.1 - 0.28 10.4 1.6 0.81 8.9 0.2 2.2 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) FAR1 PF03101.10 ESA07766.1 - 2.2e-11 44.1 0.3 3.9e-11 43.3 0.2 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA07766.1 - 4.3e-07 29.4 0.6 0.00084 18.8 0.0 2.4 2 0 0 2 2 2 2 MuDR family transposase Tox-ART-HYD1 PF15633.1 ESA07766.1 - 0.13 13.1 0.3 1.9 9.3 0.0 2.4 2 0 0 2 2 2 0 HYD1 signature containing ADP-ribosyltransferase Neur_chan_LBD PF02931.18 ESA07768.1 - 0.065 12.3 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain DUF148 PF02520.12 ESA07769.1 - 0.16 11.7 1.6 0.2 11.4 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 wnt PF00110.14 ESA07770.1 - 0.04 13.1 0.1 0.046 12.9 0.0 1.1 1 0 0 1 1 1 0 wnt family BCS1_N PF08740.6 ESA07771.1 - 0.00014 21.5 0.0 0.053 13.1 0.0 3.5 3 0 0 3 3 3 2 BCS1 N terminal zinc_ribbon_2 PF13240.1 ESA07771.1 - 0.37 10.3 27.2 2.7 7.5 0.4 6.6 6 0 0 6 6 6 0 zinc-ribbon domain SNARE PF05739.14 ESA07772.1 - 1.1e-07 31.3 4.7 1.1e-07 31.3 3.2 2.7 2 1 0 2 2 2 1 SNARE domain Spectrin PF00435.16 ESA07772.1 - 0.052 13.8 6.0 1.1 9.5 0.1 3.1 3 0 0 3 3 3 0 Spectrin repeat DUF4094 PF13334.1 ESA07772.1 - 0.087 13.2 0.1 0.087 13.2 0.1 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4094) Syntaxin_2 PF14523.1 ESA07772.1 - 0.33 10.9 19.6 0.46 10.5 7.8 2.6 2 0 0 2 2 2 0 Syntaxin-like protein IpaB_EvcA PF03278.8 ESA07774.1 - 0.053 12.7 0.3 0.085 12.0 0.1 1.4 2 0 0 2 2 2 0 IpaB/EvcA family DUF2235 PF09994.4 ESA07775.1 - 2.6e-24 86.0 0.0 3.2e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) HK97-gp10_like PF04883.7 ESA07776.1 - 0.051 14.5 0.1 14 6.6 0.0 3.0 1 1 1 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component MGS PF02142.17 ESA07776.1 - 0.75 9.7 4.7 7.4 6.5 0.1 3.1 2 1 1 3 3 3 0 MGS-like domain RestrictionMunI PF11407.3 ESA07777.1 - 0.015 14.9 1.2 0.52 9.9 0.1 2.4 2 0 0 2 2 2 0 Type II restriction enzyme MunI LRR_4 PF12799.2 ESA07777.1 - 0.17 11.5 0.1 0.17 11.5 0.1 4.9 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) p450 PF00067.17 ESA07778.1 - 1.9e-08 33.2 0.0 2.1e-08 33.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cupin_8 PF13621.1 ESA07778.1 - 0.11 12.0 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Cupin-like domain Arrestin_C PF02752.17 ESA07779.1 - 9.1e-13 48.4 5.8 4.5e-12 46.2 2.3 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ESA07779.1 - 6.6e-08 32.4 0.7 1.1e-06 28.5 0.0 2.5 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain tRNA-synt_1b PF00579.20 ESA07780.1 - 0.003 16.7 0.1 0.0037 16.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DASH_Spc19 PF08287.6 ESA07780.1 - 0.025 14.1 0.3 0.036 13.6 0.2 1.1 1 0 0 1 1 1 0 Spc19 Sel1 PF08238.7 ESA07782.1 - 4.9e-96 313.0 52.0 1.6e-11 44.4 0.5 11.0 12 0 0 12 12 12 10 Sel1 repeat TPR_6 PF13174.1 ESA07782.1 - 7.3e-06 26.1 17.1 0.16 12.4 0.1 7.6 7 1 0 7 7 7 4 Tetratricopeptide repeat SLBB PF10531.4 ESA07782.1 - 0.019 14.8 0.1 19 5.2 0.0 3.5 4 0 0 4 4 4 0 SLBB domain RQC PF09382.5 ESA07782.1 - 0.67 9.7 3.6 1.2 8.8 0.1 3.2 4 2 0 4 4 4 0 RQC domain gp37_C PF12604.3 ESA07783.1 - 0.064 13.0 0.5 0.099 12.4 0.3 1.2 1 0 0 1 1 1 0 Tail fiber protein gp37 C terminal UPF0182 PF03699.8 ESA07784.1 - 0.025 12.5 0.3 0.026 12.4 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) G-7-MTase PF12803.2 ESA07784.1 - 0.068 12.3 0.1 0.075 12.1 0.1 1.0 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) DUF3187 PF11383.3 ESA07784.1 - 0.084 11.9 0.8 0.095 11.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3187) FokI_N PF02981.10 ESA07785.1 - 0.1 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease FokI, recognition domain PRELI PF04707.9 ESA07787.1 - 3.5e-47 159.8 0.0 4e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family RRM_1 PF00076.17 ESA07788.1 - 7.7e-14 51.0 0.1 1.9e-13 49.8 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA07788.1 - 4.5e-13 48.9 0.0 7.9e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA07788.1 - 2.6e-10 40.0 0.2 5e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IGR PF09597.5 ESA07788.1 - 0.018 14.8 0.9 0.058 13.3 0.6 1.8 1 0 0 1 1 1 0 IGR protein motif IL31 PF15209.1 ESA07789.1 - 0.039 13.5 0.3 0.11 12.1 0.2 1.7 1 0 0 1 1 1 0 Interleukin 31 PSRP-3_Ycf65 PF04839.8 ESA07790.1 - 0.13 12.3 1.3 0.18 11.9 0.9 1.2 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) p450 PF00067.17 ESA07791.1 - 5.2e-23 81.2 0.0 9.4e-23 80.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Sel1 PF08238.7 ESA07792.1 - 3.1e-110 358.2 57.4 2.1e-11 44.0 0.4 14.1 14 0 0 14 14 14 14 Sel1 repeat TPR_6 PF13174.1 ESA07792.1 - 3.2e-11 42.8 33.7 0.8 10.3 0.1 11.2 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_7 PF13176.1 ESA07792.1 - 0.024 14.4 7.0 2.5 8.1 0.0 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat p450 PF00067.17 ESA07793.1 - 2.4e-75 253.8 0.2 2.9e-75 253.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAA PF00004.24 ESA07794.1 - 0.027 14.6 0.0 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA07794.1 - 0.086 12.5 0.0 3.3 7.4 0.0 3.2 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) CRT10 PF08728.5 ESA07795.1 - 0.00034 18.7 1.7 0.00038 18.5 1.1 1.0 1 0 0 1 1 1 1 CRT10 p450 PF00067.17 ESA07797.1 - 2.2e-82 277.0 0.6 2.6e-82 276.7 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 NYN PF01936.13 ESA07798.1 - 1e-05 25.8 0.0 1.8e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 NYN domain Tim17 PF02466.14 ESA07801.1 - 2.2e-11 43.8 0.5 6.4e-11 42.4 0.3 1.8 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF637 PF04830.8 ESA07801.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Possible hemagglutinin (DUF637) Sel1 PF08238.7 ESA07804.1 - 3.3e-113 367.6 43.6 1.8e-11 44.3 0.2 12.0 12 0 0 12 12 12 11 Sel1 repeat TPR_6 PF13174.1 ESA07804.1 - 6.2e-12 45.1 21.5 0.79 10.3 0.0 9.2 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESA07804.1 - 0.017 15.2 16.1 45 4.5 0.0 8.7 9 1 1 10 10 10 0 Tetratricopeptide repeat UPF0175 PF03683.8 ESA07804.1 - 0.022 14.2 0.6 16 5.0 0.0 3.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0175) TPR_20 PF14561.1 ESA07804.1 - 0.075 13.1 0.2 67 3.6 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2761 PF10959.3 ESA07804.1 - 0.39 10.3 2.9 36 4.0 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2761) Leuk-A4-hydro_C PF09127.6 ESA07804.1 - 0.89 9.1 4.5 4.7 6.8 0.0 3.6 3 1 1 4 4 4 0 Leukotriene A4 hydrolase, C-terminal Pkinase_Tyr PF07714.12 ESA07805.1 - 4.3e-30 104.6 0.0 5.2e-30 104.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07805.1 - 1.8e-29 102.6 0.1 2.1e-29 102.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07805.1 - 0.0014 17.7 0.0 0.0017 17.4 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA07805.1 - 0.0057 16.0 0.2 0.0073 15.6 0.1 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA07805.1 - 0.0089 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PLA1 PF02253.10 ESA07805.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Phospholipase A1 WaaY PF06176.6 ESA07805.1 - 0.014 14.6 0.1 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA07805.1 - 0.033 13.5 0.0 0.045 13.0 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Aldolase_2 PF10120.4 ESA07806.1 - 0.043 13.1 0.4 0.061 12.6 0.3 1.2 1 0 0 1 1 1 0 Putative aldolase Pox_vIL-18BP PF05566.7 ESA07807.1 - 0.016 15.2 0.1 0.019 15.0 0.0 1.1 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein Ta0938 PF11494.3 ESA07807.1 - 0.038 14.1 0.1 0.039 14.0 0.1 1.2 1 0 0 1 1 1 0 Ta0938 FliE PF02049.13 ESA07807.1 - 0.071 13.1 0.5 0.095 12.7 0.4 1.2 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE DUF3510 PF12022.3 ESA07808.1 - 0.089 12.8 0.7 0.099 12.7 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) AAA_23 PF13476.1 ESA07809.1 - 1.2e-15 58.3 25.9 1.2e-15 58.3 17.9 5.6 2 2 2 4 4 4 1 AAA domain SMC_N PF02463.14 ESA07809.1 - 4.8e-13 48.8 40.1 2.9e-12 46.2 27.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA07809.1 - 2.5e-05 24.3 0.2 2.5e-05 24.3 0.1 5.0 3 2 0 3 3 3 1 AAA domain AAA_29 PF13555.1 ESA07809.1 - 0.00018 20.9 0.0 0.00039 19.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 ESA07809.1 - 0.041 13.2 3.8 0.045 13.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 ESA07809.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESA07809.1 - 0.11 12.6 0.0 0.11 12.6 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Reo_sigmaC PF04582.7 ESA07809.1 - 1.5 7.9 19.7 0.12 11.5 0.2 4.2 3 1 0 4 4 4 0 Reovirus sigma C capsid protein ubiquitin PF00240.18 ESA07810.1 - 1.1e-16 59.9 0.3 2e-16 59.1 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA07810.1 - 1.2e-09 37.7 0.3 2.4e-09 36.7 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA07810.1 - 1.2e-06 28.7 0.4 6.3e-06 26.3 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain PARP PF00644.15 ESA07810.1 - 0.00083 18.8 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF2407 PF10302.4 ESA07810.1 - 0.0023 18.1 0.0 0.0039 17.3 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA07810.1 - 0.014 15.2 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF996 PF06195.8 ESA07812.1 - 0.61 10.0 11.6 0.033 14.1 3.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF996) Methyltransf_11 PF08241.7 ESA07815.1 - 3.5e-10 40.2 0.0 6.6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA07815.1 - 4.8e-10 39.3 0.0 5.6e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA07815.1 - 1.3e-07 31.3 0.1 5.5e-06 26.0 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA07815.1 - 2.5e-07 29.9 0.0 0.00023 20.2 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase Ubie_methyltran PF01209.13 ESA07815.1 - 1.2e-06 27.8 0.1 4.3e-05 22.7 0.1 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA07815.1 - 1.1e-05 25.6 0.0 9e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA07815.1 - 8.5e-05 22.9 0.0 0.00026 21.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.6 ESA07815.1 - 8.6e-05 22.2 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_29 PF03141.11 ESA07815.1 - 0.00043 18.7 0.1 0.00083 17.8 0.0 1.5 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_18 PF12847.2 ESA07815.1 - 0.0011 19.5 0.1 0.12 12.9 0.1 2.3 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA07815.1 - 0.0071 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase CheR PF01739.13 ESA07815.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain DOT1 PF08123.8 ESA07815.1 - 0.017 14.4 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 BTB PF00651.26 ESA07816.1 - 7.9e-18 64.4 0.2 3.1e-17 62.5 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA07816.1 - 7.8e-11 42.1 0.3 1.7e-10 40.9 0.2 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA07816.1 - 2.3e-05 24.1 2.5 2.7e-05 23.9 0.2 2.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA07816.1 - 0.031 14.4 0.0 0.22 11.7 0.0 2.2 1 1 1 2 2 2 0 BTB/POZ domain PX PF00787.19 ESA07817.1 - 1.9e-21 75.9 1.5 4.4e-21 74.7 0.1 2.3 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 ESA07817.1 - 1.3e-18 67.1 10.3 7.4e-14 51.5 0.3 2.2 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.13 ESA07817.1 - 1.1e-06 28.3 11.3 4.7e-05 23.0 8.8 2.4 2 1 0 2 2 2 1 BAR domain TBPIP PF07106.8 ESA07817.1 - 0.005 16.4 11.2 0.096 12.2 0.5 2.9 4 0 0 4 4 4 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin PF00804.20 ESA07817.1 - 0.035 14.2 3.6 0.13 12.4 0.2 2.6 2 0 0 2 2 2 0 Syntaxin CCT_2 PF09425.5 ESA07817.1 - 0.048 13.2 3.5 0.11 12.1 2.4 1.6 1 0 0 1 1 1 0 Divergent CCT motif Atg14 PF10186.4 ESA07817.1 - 0.14 11.0 5.8 1.2 8.0 2.0 2.2 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 NPV_P10 PF05531.7 ESA07817.1 - 0.15 12.3 2.8 6.7 7.0 0.1 3.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein IFP_35_N PF07334.8 ESA07817.1 - 0.6 10.1 7.7 1.4 8.9 1.1 2.5 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF1664 PF07889.7 ESA07817.1 - 3.5 7.4 7.1 8.6 6.1 1.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Sel1 PF08238.7 ESA07819.1 - 3.5e-61 202.2 35.7 3.7e-08 33.7 0.6 11.3 11 2 0 11 11 11 9 Sel1 repeat Exo_endo_phos_2 PF14529.1 ESA07819.1 - 0.00094 18.7 0.1 0.27 10.8 0.0 2.5 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase EF-hand_10 PF14788.1 ESA07819.1 - 0.04 13.5 3.3 6.2 6.5 0.0 3.6 4 0 0 4 4 4 0 EF hand MIT PF04212.13 ESA07819.1 - 0.19 11.6 11.7 27 4.7 0.1 5.9 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA07819.1 - 0.91 9.2 3.6 16 5.2 0.0 4.0 3 1 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation TPR_11 PF13414.1 ESA07819.1 - 1.2 8.8 31.3 0.16 11.6 0.4 6.3 3 2 3 6 6 6 0 TPR repeat Pkinase PF00069.20 ESA07821.1 - 7.3e-53 179.3 1.8 1.5e-52 178.2 1.3 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07821.1 - 1.6e-51 174.9 0.2 2.8e-51 174.0 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA07821.1 - 0.00035 19.9 0.4 0.00083 18.7 0.3 1.7 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA07821.1 - 0.00084 18.3 0.0 0.0017 17.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA07821.1 - 0.0027 17.0 0.6 0.013 14.8 0.4 2.1 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA07821.1 - 0.0086 15.1 0.1 0.017 14.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA07821.1 - 0.019 14.6 0.3 0.072 12.8 0.2 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Fer4_13 PF13370.1 ESA07822.1 - 0.3 11.5 1.3 0.42 11.0 0.1 1.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain UNC45-central PF11701.3 ESA07825.1 - 0.00056 19.5 0.9 0.00056 19.5 0.6 2.1 2 1 0 2 2 2 1 Myosin-binding striated muscle assembly central Suf PF05843.9 ESA07825.1 - 0.006 16.3 3.3 0.0074 16.0 1.1 1.8 1 1 1 2 2 2 1 Suppressor of forked protein (Suf) Sel1 PF08238.7 ESA07826.1 - 6.3e-16 58.4 0.7 2.7e-05 24.6 0.2 3.9 4 0 0 4 4 4 3 Sel1 repeat PHY PF00360.15 ESA07826.1 - 0.15 11.1 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Phytochrome region TFIID_20kDa PF03847.8 ESA07827.1 - 0.1 12.9 0.1 0.39 11.0 0.0 1.9 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Pkinase PF00069.20 ESA07828.1 - 7.8e-32 110.4 0.0 1.1e-31 109.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07828.1 - 2.3e-28 98.9 0.0 2.8e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA07828.1 - 0.075 12.7 0.1 0.16 11.6 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA07828.1 - 0.15 11.0 0.2 0.23 10.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PHD PF00628.24 ESA07829.1 - 1.7e-08 34.0 12.3 3.2e-08 33.1 8.5 1.5 1 0 0 1 1 1 1 PHD-finger Linker_histone PF00538.14 ESA07829.1 - 0.00014 21.8 0.2 0.00041 20.3 0.1 1.8 1 0 0 1 1 1 1 linker histone H1 and H5 family PHD_2 PF13831.1 ESA07829.1 - 0.0018 17.5 4.7 0.0045 16.2 3.2 1.7 1 1 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.1 ESA07829.1 - 0.0058 16.3 9.5 0.013 15.2 6.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Tnp_zf-ribbon_2 PF13842.1 ESA07829.1 - 1.3 9.4 11.0 2.9 8.3 4.5 2.5 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon FAD_binding_3 PF01494.14 ESA07833.1 - 2e-12 46.8 0.0 7.6e-09 35.0 0.0 3.2 3 1 0 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.1 ESA07833.1 - 1.5e-05 25.1 0.0 0.00011 22.3 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA07833.1 - 4.3e-05 23.3 0.0 0.00016 21.4 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA07833.1 - 0.0024 17.8 0.0 0.0052 16.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 ESA07833.1 - 0.0056 15.6 0.0 0.77 8.6 0.0 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 ESA07833.1 - 0.024 14.5 0.0 0.063 13.1 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESA07833.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Sec2p PF06428.6 ESA07834.1 - 8.7e-14 51.2 13.1 8.7e-14 51.2 9.1 2.6 2 1 1 3 3 2 1 GDP/GTP exchange factor Sec2p ATG16 PF08614.6 ESA07834.1 - 0.059 13.1 25.9 0.046 13.5 7.5 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Vip3A_N PF12495.3 ESA07834.1 - 0.18 11.4 2.0 0.45 10.1 1.2 1.7 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal AAA_27 PF13514.1 ESA07834.1 - 0.35 8.5 17.1 0.5 7.9 11.8 1.1 1 0 0 1 1 1 0 AAA domain Ribosomal_S3Ae PF01015.13 ESA07834.1 - 0.37 10.0 5.3 15 4.8 3.7 2.3 1 1 0 1 1 1 0 Ribosomal S3Ae family MscS_porin PF12795.2 ESA07834.1 - 0.58 9.4 22.5 0.35 10.1 13.2 2.4 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain BRE1 PF08647.6 ESA07834.1 - 0.83 9.6 17.6 0.2 11.6 6.4 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase TMF_DNA_bd PF12329.3 ESA07834.1 - 1.8 8.4 22.7 0.84 9.4 5.0 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Fzo_mitofusin PF04799.8 ESA07834.1 - 2 7.8 8.6 1.4 8.2 0.6 2.4 2 0 0 2 2 2 0 fzo-like conserved region Mod_r PF07200.8 ESA07834.1 - 2.3 8.1 26.7 4.6 7.1 7.2 2.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4140 PF13600.1 ESA07834.1 - 3.4 8.1 14.3 0.54 10.7 1.1 3.1 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Viral_P18 PF04521.8 ESA07834.1 - 3.9 6.9 7.8 2.6 7.4 0.2 2.6 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Orbi_VP5 PF00901.12 ESA07834.1 - 4.6 5.3 17.3 4.1 5.5 10.9 1.5 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP5 Spc7 PF08317.6 ESA07834.1 - 5.2 5.6 22.7 2.3 6.8 6.9 2.6 2 1 1 3 3 3 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.17 ESA07834.1 - 6.2 6.8 23.8 0.32 11.0 4.5 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FliD_C PF07195.7 ESA07834.1 - 6.8 5.9 11.6 73 2.5 7.7 2.2 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus APG6 PF04111.7 ESA07834.1 - 7.4 5.5 23.0 3 6.8 5.9 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 IncA PF04156.9 ESA07834.1 - 7.4 6.1 30.3 0.47 10.0 7.7 2.4 1 1 1 2 2 2 0 IncA protein Atg14 PF10186.4 ESA07834.1 - 8.5 5.2 22.0 2.1 7.2 5.2 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1256 PF06866.6 ESA07835.1 - 0.041 13.0 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) PAT1 PF09770.4 ESA07837.1 - 0.00015 20.1 31.2 0.00021 19.7 21.6 1.3 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 ESA07837.1 - 0.0009 17.0 15.7 0.0012 16.7 10.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) FimP PF09766.4 ESA07837.1 - 0.0046 16.0 11.2 0.0046 16.0 7.8 1.7 2 0 0 2 2 2 1 Fms-interacting protein UPF0560 PF10577.4 ESA07837.1 - 0.038 12.2 14.7 0.061 11.5 10.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Band_3_cyto PF07565.8 ESA07837.1 - 0.047 13.1 2.3 0.078 12.4 1.6 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Serinc PF03348.10 ESA07837.1 - 0.22 10.1 2.7 0.35 9.5 1.9 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) FTSW_RODA_SPOVE PF01098.14 ESA07838.1 - 0.16 10.6 7.4 0.19 10.4 5.1 1.1 1 0 0 1 1 1 0 Cell cycle protein BTB PF00651.26 ESA07839.1 - 1.9e-17 63.2 0.2 1.9e-17 63.2 0.1 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA07839.1 - 7.6e-07 28.9 0.2 4.9e-06 26.3 0.1 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch TLD PF07534.11 ESA07839.1 - 1.6e-06 28.1 0.3 4e-06 26.8 0.2 1.7 2 0 0 2 2 2 1 TLD Peptidase_C97 PF05903.9 ESA07841.1 - 9.3e-42 142.3 0.0 1e-41 142.1 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF3816 PF12822.2 ESA07842.1 - 0.037 13.9 0.8 0.042 13.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3816) Pkinase_Tyr PF07714.12 ESA07844.1 - 1.6e-06 27.3 0.2 3e-06 26.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07844.1 - 0.00071 18.7 0.0 0.0029 16.8 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Pkinase_C PF00433.19 ESA07844.1 - 0.037 14.5 0.1 0.088 13.3 0.0 1.6 2 0 0 2 2 2 0 Protein kinase C terminal domain Abhydrolase_3 PF07859.8 ESA07845.1 - 0.0004 20.0 0.0 0.00073 19.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold PepSY_2 PF13670.1 ESA07845.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Phage_CII PF05269.6 ESA07846.1 - 0.038 13.9 0.1 0.046 13.7 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage CII protein DUF606 PF04657.8 ESA07847.1 - 2.3e-26 92.5 10.8 2.6e-26 92.3 7.5 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF606 Rad50_zn_hook PF04423.9 ESA07848.1 - 0.0098 15.3 0.6 0.016 14.6 0.4 1.4 1 0 0 1 1 1 1 Rad50 zinc hook motif Haem_bd PF14376.1 ESA07848.1 - 0.15 11.7 0.9 0.21 11.3 0.6 1.2 1 0 0 1 1 1 0 Haem-binding domain Abhydrolase_3 PF07859.8 ESA07849.1 - 0.064 12.8 0.1 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Kelch_4 PF13418.1 ESA07850.1 - 5.4e-18 64.4 13.6 0.00059 19.5 0.0 6.5 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA07850.1 - 2.6e-16 59.0 13.7 0.0053 16.8 0.1 6.5 4 1 2 6 6 6 5 Kelch motif Kelch_5 PF13854.1 ESA07850.1 - 1.3e-13 50.5 11.8 0.00032 20.5 0.1 5.9 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.20 ESA07850.1 - 5.3e-13 48.2 14.0 0.0001 21.7 0.3 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA07850.1 - 1.9e-12 46.9 7.5 1.9e-05 24.6 0.0 6.0 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA07850.1 - 5.2e-12 45.0 13.2 0.0011 18.6 0.0 6.0 5 1 0 5 5 5 4 Kelch motif Glyco_transf_5 PF08323.6 ESA07853.1 - 3.5e-19 69.2 0.0 6e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 ESA07853.1 - 1.3e-08 34.4 0.1 2.5e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ESA07853.1 - 0.26 11.4 0.0 0.49 10.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain E1-E2_ATPase PF00122.15 ESA07854.1 - 1.4e-41 142.0 0.6 1.4e-41 142.0 0.4 1.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 ESA07854.1 - 4.7e-15 54.8 0.0 7.1e-15 54.2 0.0 1.3 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Acyl-thio_N PF12590.3 ESA07854.1 - 0.014 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Acyl-ATP thioesterase Sec7 PF01369.15 ESA07855.1 - 2.8e-65 219.5 0.0 8.8e-65 217.9 0.0 1.9 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESA07855.1 - 7.6e-42 142.5 11.0 7.6e-42 142.5 7.6 3.2 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 ESA07855.1 - 7.6e-26 89.4 3.9 1.3e-24 85.5 0.1 4.8 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) RhoGEF PF00621.15 ESA07856.1 - 6.2e-42 143.5 4.7 9.8e-42 142.8 3.3 1.3 1 0 0 1 1 1 1 RhoGEF domain Rad60-SLD PF11976.3 ESA07857.1 - 0.22 11.2 1.0 3.5 7.4 0.1 2.2 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like CBM_20 PF00686.14 ESA07859.1 - 8.2e-05 22.1 0.2 0.00021 20.7 0.1 1.6 1 1 0 1 1 1 1 Starch binding domain Pkinase_Tyr PF07714.12 ESA07860.1 - 1.1e-38 132.8 0.0 1.3e-38 132.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07860.1 - 1.8e-34 119.0 0.0 2.1e-34 118.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA07860.1 - 7e-05 22.6 0.2 0.00015 21.5 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA07860.1 - 0.0018 17.3 0.1 0.0024 16.9 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PsbU PF06514.6 ESA07860.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) RIO1 PF01163.17 ESA07860.1 - 0.088 12.1 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 RIO1 family HMG_box PF00505.14 ESA07861.1 - 2e-07 31.1 2.1 4.5e-07 30.0 1.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HLH PF00010.21 ESA07863.1 - 3.1e-14 52.3 0.7 3.1e-14 52.3 0.5 2.8 3 1 0 3 3 3 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.16 ESA07863.1 - 0.0058 16.5 0.9 0.0058 16.5 0.6 2.1 2 0 0 2 2 2 1 bZIP transcription factor DUF605 PF04652.11 ESA07863.1 - 0.019 14.3 16.5 0.021 14.2 11.4 1.2 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 ESA07863.1 - 0.14 10.3 22.7 0.17 10.1 15.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 IncA PF04156.9 ESA07863.1 - 8.1 5.9 8.4 1.4 8.4 2.9 1.9 2 0 0 2 2 2 0 IncA protein Sel1 PF08238.7 ESA07865.1 - 2.3e-59 196.4 26.3 5e-11 42.8 0.2 6.8 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.1 ESA07865.1 - 0.00019 21.6 8.0 13 6.5 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat Sel1 PF08238.7 ESA07866.1 - 2.6e-216 695.3 90.4 3.5e-11 43.3 0.1 24.0 23 1 0 23 23 23 23 Sel1 repeat Pkinase_Tyr PF07714.12 ESA07866.1 - 1.2e-44 152.3 0.0 1.9e-44 151.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07866.1 - 6.6e-41 140.1 0.4 6.6e-41 140.1 0.3 2.0 2 0 0 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA07866.1 - 3.3e-11 42.8 51.3 0.75 10.3 0.0 18.0 20 0 0 20 20 20 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA07866.1 - 9e-05 22.4 4.1 22 5.1 0.0 6.9 7 1 1 8 8 8 0 Influenza Matrix protein (M1) C-terminal domain RIO1 PF01163.17 ESA07866.1 - 0.0017 17.7 0.4 0.0056 16.0 0.3 1.9 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA07866.1 - 0.0052 15.8 0.1 0.011 14.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA07866.1 - 0.029 13.3 0.0 0.05 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA07866.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_14 PF13173.1 ESA07868.1 - 0.009 15.9 5.0 2.5 8.0 0.1 3.3 2 1 0 2 2 2 2 AAA domain Sel1 PF08238.7 ESA07870.1 - 8.6e-16 58.0 9.1 5.2e-08 33.2 0.1 3.7 3 0 0 3 3 3 2 Sel1 repeat TPR_6 PF13174.1 ESA07870.1 - 0.001 19.3 3.0 0.6 10.6 0.1 3.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA07870.1 - 0.0049 17.5 0.2 0.11 13.2 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA07870.1 - 0.025 14.9 1.4 12 6.3 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07870.1 - 0.1 12.2 7.7 0.24 11.0 2.5 3.3 2 1 1 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESA07870.1 - 4.9 7.3 13.5 0.62 10.1 0.3 4.8 5 1 1 6 6 6 0 Tetratricopeptide repeat Kelch_4 PF13418.1 ESA07873.1 - 8.9e-17 60.5 8.7 6.6e-05 22.6 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA07873.1 - 9.6e-15 54.2 7.7 0.0031 17.6 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA07873.1 - 3.4e-12 46.0 13.6 0.0014 18.5 0.0 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA07873.1 - 8.7e-09 35.1 13.2 0.016 15.3 0.1 5.6 3 2 2 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA07873.1 - 1.2e-07 31.1 1.1 0.82 9.5 0.0 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA07873.1 - 5e-06 25.9 20.5 0.00018 20.9 0.1 4.7 5 1 0 5 5 5 3 Kelch motif Rax2 PF12768.2 ESA07873.1 - 0.0014 17.9 0.7 0.19 10.9 0.1 2.9 2 1 1 3 3 3 1 Cortical protein marker for cell polarity DCP1 PF06058.8 ESA07873.1 - 0.078 13.0 0.1 28 4.7 0.0 3.3 3 0 0 3 3 3 0 Dcp1-like decapping family DUF3989 PF13150.1 ESA07873.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) Kelch_4 PF13418.1 ESA07874.1 - 4.5e-16 58.3 6.0 0.00018 21.1 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA07874.1 - 9.7e-15 54.2 7.0 0.0023 18.0 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA07874.1 - 1.3e-13 50.5 7.1 0.00074 19.4 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.1 ESA07874.1 - 4.7e-08 32.8 11.4 0.027 14.6 0.1 5.3 3 2 2 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA07874.1 - 1.5e-07 30.8 0.5 0.66 9.8 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA07874.1 - 2.4e-07 30.1 12.3 0.00058 19.3 0.2 4.5 5 0 0 5 5 5 3 Kelch motif Rax2 PF12768.2 ESA07874.1 - 0.0011 18.2 0.5 0.27 10.4 0.2 3.2 3 1 1 4 4 4 1 Cortical protein marker for cell polarity DUF3989 PF13150.1 ESA07874.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) DCP1 PF06058.8 ESA07874.1 - 0.092 12.7 0.1 14 5.7 0.0 3.1 3 0 0 3 3 3 0 Dcp1-like decapping family Pkinase_Tyr PF07714.12 ESA07875.1 - 3.5e-13 49.2 0.0 3.9e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07875.1 - 1.2e-12 47.5 0.0 1.4e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PLA2_inh PF02988.10 ESA07876.1 - 0.11 13.0 0.1 0.15 12.5 0.1 1.2 1 0 0 1 1 1 0 Phospholipase A2 inhibitor Sel1 PF08238.7 ESA07878.1 - 2.2e-150 485.8 103.0 2.3e-12 47.1 1.2 17.1 17 0 0 17 17 17 17 Sel1 repeat TPR_6 PF13174.1 ESA07878.1 - 2.2e-06 27.7 44.3 0.65 10.5 0.1 11.4 13 0 0 13 13 13 6 Tetratricopeptide repeat CBM_20 PF00686.14 ESA07879.1 - 5.3e-05 22.7 0.0 0.00038 20.0 0.0 2.6 1 0 0 1 1 1 1 Starch binding domain F-box-like PF12937.2 ESA07880.1 - 0.0062 16.2 0.2 0.014 15.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like SPRY PF00622.23 ESA07881.1 - 3.4e-14 53.0 0.9 6.2e-14 52.1 0.6 1.5 1 0 0 1 1 1 1 SPRY domain DUF2533 PF10752.4 ESA07881.1 - 0.0068 16.6 0.9 0.017 15.4 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2533) ThiC PF01964.13 ESA07881.1 - 0.036 12.5 0.2 0.17 10.3 0.0 1.9 2 0 0 2 2 2 0 ThiC family DUF4410 PF14366.1 ESA07881.1 - 0.12 12.1 0.7 0.29 10.8 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) Zip PF02535.17 ESA07881.1 - 0.15 11.0 2.2 0.21 10.5 1.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter HHH_5 PF14520.1 ESA07881.1 - 0.17 12.0 0.7 0.3 11.2 0.5 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix domain Malic_M PF03949.10 ESA07883.1 - 1.4e-79 267.2 0.0 1.8e-79 266.8 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 ESA07883.1 - 6e-59 198.6 0.0 9.9e-59 197.9 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DUF816 PF05674.7 ESA07884.1 - 0.12 12.1 4.3 0.57 9.8 2.0 1.9 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF816) HMG_box PF00505.14 ESA07886.1 - 2.7e-22 78.8 2.2 3.5e-22 78.4 1.5 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA07886.1 - 1.4e-08 35.0 1.1 1.7e-08 34.6 0.8 1.2 1 0 0 1 1 1 1 HMG-box domain Sel1 PF08238.7 ESA07887.1 - 2e-110 358.8 55.8 2e-10 40.9 0.5 13.2 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA07887.1 - 5.2e-07 29.7 19.6 1.4 9.5 0.1 8.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA07887.1 - 2.1 9.1 10.7 7.5 7.3 0.0 5.6 5 2 2 7 7 7 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA07888.1 - 2.1e-27 95.8 0.0 2.3e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07888.1 - 3.5e-27 95.1 0.2 3.9e-27 95.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA07888.1 - 0.0017 17.4 0.0 0.0021 17.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA07888.1 - 0.038 13.7 0.1 0.066 12.9 0.1 1.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family TLD PF07534.11 ESA07893.1 - 8.9e-09 35.4 2.1 1.4e-08 34.8 0.6 1.9 2 0 0 2 2 2 1 TLD Pkinase PF00069.20 ESA07894.1 - 1.1e-35 123.0 0.2 1.3e-35 122.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07894.1 - 6e-35 120.5 0.0 7.4e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA07894.1 - 0.00074 18.6 0.1 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA07894.1 - 0.0019 17.9 0.3 0.04 13.6 0.2 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA07894.1 - 0.0089 15.3 0.2 0.013 14.8 0.2 1.4 1 1 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA07894.1 - 0.015 14.5 0.1 0.024 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF4286 PF14114.1 ESA07894.1 - 0.24 11.7 2.7 1.9 8.8 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) NUDE_C PF04880.8 ESA07896.1 - 2.5e-16 60.4 0.9 2.5e-16 60.4 0.6 2.6 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region Bacillus_HBL PF05791.6 ESA07896.1 - 0.001 18.4 2.1 0.001 18.4 1.4 3.1 1 1 2 3 3 3 1 Bacillus haemolytic enterotoxin (HBL) TPR_MLP1_2 PF07926.7 ESA07896.1 - 0.0015 18.2 11.5 0.0015 18.2 7.9 3.1 1 1 2 3 3 3 2 TPR/MLP1/MLP2-like protein Exonuc_VII_L PF02601.10 ESA07896.1 - 0.039 13.1 12.5 0.046 12.9 8.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.6 ESA07896.1 - 0.25 10.5 10.4 0.28 10.4 0.2 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Glu_syn_central PF04898.9 ESA07896.1 - 0.6 9.3 5.7 0.69 9.1 3.6 1.4 1 1 0 1 1 1 0 Glutamate synthase central domain LAGLIDADG_3 PF14528.1 ESA07896.1 - 0.93 9.7 3.9 1.1 9.5 0.8 2.3 2 0 0 2 2 2 0 LAGLIDADG-like domain TMPIT PF07851.8 ESA07896.1 - 2 7.3 14.1 0.21 10.6 6.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein Mod_r PF07200.8 ESA07896.1 - 3.6 7.5 26.8 2.4 8.0 10.7 3.0 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF1064 PF06356.6 ESA07896.1 - 3.6 7.6 7.1 6.5 6.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1064) DUF2937 PF11157.3 ESA07896.1 - 9.7 5.4 7.6 9.3 5.5 4.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2937) SWIRM PF04433.12 ESA07897.1 - 0.089 12.9 0.4 0.13 12.4 0.3 1.4 1 1 0 1 1 1 0 SWIRM domain Pkinase_Tyr PF07714.12 ESA07898.1 - 1.1e-47 162.3 0.0 1.6e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07898.1 - 8.8e-47 159.4 0.3 8.8e-47 159.4 0.2 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA07898.1 - 2.9e-14 53.1 2.9 4.6e-05 23.8 0.0 3.5 3 0 0 3 3 3 3 Sel1 repeat Kinase-like PF14531.1 ESA07898.1 - 0.0019 17.2 0.0 0.0082 15.1 0.0 1.9 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA07898.1 - 0.0051 15.8 0.2 0.0093 15.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA07898.1 - 0.27 10.9 0.2 0.65 9.6 0.2 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family ATP-cone PF03477.11 ESA07898.1 - 0.7 10.3 4.3 0.45 10.9 0.8 2.2 2 0 0 2 2 2 0 ATP cone domain RNase_H PF00075.19 ESA07899.1 - 4.6e-07 30.2 0.1 8.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 RNase H dCMP_cyt_deam_1 PF00383.17 ESA07899.1 - 0.082 12.5 0.1 13 5.5 0.0 2.3 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region Clp1 PF06807.9 ESA07900.1 - 2.8e-16 59.8 0.0 9.2e-16 58.1 0.0 1.8 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 ESA07900.1 - 2.8e-07 30.3 0.0 5.9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 ESA07900.1 - 0.0056 16.6 0.1 0.83 9.6 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase Ribosomal_S25 PF03297.10 ESA07901.1 - 8.7e-45 151.0 3.6 9.8e-45 150.9 2.5 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.2 ESA07901.1 - 0.0049 16.4 0.3 0.0089 15.6 0.1 1.4 1 1 0 1 1 1 1 MarR family HTH_24 PF13412.1 ESA07901.1 - 0.022 14.1 0.1 0.032 13.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.17 ESA07901.1 - 0.073 12.7 0.4 0.11 12.2 0.0 1.5 2 0 0 2 2 2 0 MarR family Vps5 PF09325.5 ESA07902.1 - 1.2e-67 227.6 18.7 2.7e-67 226.5 13.0 1.6 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 ESA07902.1 - 1.7e-07 30.9 3.6 4.4e-06 26.4 0.1 3.3 3 1 0 3 3 3 1 PX domain BAR_3_WASP_bdg PF10456.4 ESA07902.1 - 0.00016 21.0 5.1 0.054 12.7 0.9 2.3 1 1 0 2 2 2 2 WASP-binding domain of Sorting nexin protein BAR PF03114.13 ESA07902.1 - 0.0003 20.3 13.9 0.0077 15.7 4.1 2.4 3 0 0 3 3 3 2 BAR domain Nop PF01798.13 ESA07902.1 - 0.0028 16.9 0.1 0.0071 15.6 0.1 1.8 1 0 0 1 1 1 1 Putative snoRNA binding domain hDGE_amylase PF14701.1 ESA07902.1 - 0.25 10.1 9.6 0.1 11.4 4.8 1.7 1 1 1 2 2 2 0 glucanotransferase domain of human glycogen debranching enzyme DUF3437 PF11919.3 ESA07902.1 - 0.76 9.5 4.6 0.51 10.0 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3437) Reo_sigmaC PF04582.7 ESA07902.1 - 0.76 8.8 5.1 0.84 8.7 2.0 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 ESA07902.1 - 1.2 8.9 17.9 0.92 9.3 2.8 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.7 ESA07902.1 - 1.7 8.4 9.3 13 5.5 1.1 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CorA PF01544.13 ESA07902.1 - 3.9 6.4 8.4 1.2 8.1 0.6 2.4 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF848 PF05852.6 ESA07902.1 - 4.5 7.1 15.6 1.3 8.8 4.3 2.8 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) GrpE PF01025.14 ESA07902.1 - 7.7 6.0 14.4 0.66 9.5 3.5 3.0 3 1 0 3 3 3 0 GrpE STT3 PF02516.9 ESA07903.1 - 3.8e-127 425.1 45.0 4.9e-123 411.6 28.1 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit HAUS2 PF15003.1 ESA07904.1 - 7.3e-05 21.9 0.0 8.1e-05 21.8 0.0 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 TRAPPC9-Trs120 PF08626.6 ESA07905.1 - 0.026 11.8 0.1 0.027 11.8 0.0 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit ubiquitin PF00240.18 ESA07905.1 - 0.047 13.0 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family Ubiquitin_2 PF14560.1 ESA07905.1 - 0.16 12.2 0.4 0.37 11.0 0.1 1.7 2 1 0 2 2 2 0 Ubiquitin-like domain E1-E2_ATPase PF00122.15 ESA07906.1 - 4.5e-47 160.0 0.9 4.5e-47 160.0 0.6 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESA07906.1 - 8.1e-42 144.0 0.0 1.3e-41 143.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 ESA07906.1 - 1.1e-22 79.8 0.0 3.9e-12 46.1 0.0 2.8 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.2 ESA07906.1 - 8.9e-15 55.3 0.0 2.1e-14 54.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA07906.1 - 0.00017 21.2 1.0 0.052 13.1 0.0 3.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA07906.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF418 PF04235.7 ESA07906.1 - 0.26 10.9 7.2 0.12 11.9 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF418) RicinB_lectin_2 PF14200.1 ESA07908.1 - 4e-11 43.2 4.3 8.9e-11 42.0 2.5 2.0 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA07908.1 - 0.00063 19.7 4.3 0.11 12.5 0.9 2.5 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain BTB PF00651.26 ESA07909.1 - 3.7e-11 42.9 0.0 4.3e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA07910.1 - 6.1e-18 65.1 1.8 7.8e-18 64.8 1.2 1.1 1 0 0 1 1 1 1 TLD PH_9 PF15410.1 ESA07912.1 - 9.2e-11 41.9 0.5 4.5e-10 39.7 0.4 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESA07912.1 - 5.4e-08 32.9 0.9 1.2e-07 31.8 0.6 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESA07912.1 - 1.3 9.2 4.0 0.93 9.7 0.9 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain DNA_pol_B PF00136.16 ESA07913.1 - 0.00091 18.1 0.0 0.00097 18.0 0.0 1.2 1 1 0 1 1 1 1 DNA polymerase family B WASH-7_C PF14746.1 ESA07914.1 - 0.014 15.0 0.6 0.06 12.9 1.2 1.4 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal DUF2533 PF10752.4 ESA07914.1 - 0.036 14.3 0.7 0.078 13.2 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2533) HSP70 PF00012.15 ESA07915.1 - 0.15 9.8 4.8 0.17 9.7 3.3 1.0 1 0 0 1 1 1 0 Hsp70 protein MULE PF10551.4 ESA07917.1 - 1.8e-06 27.9 0.0 5.5e-06 26.4 0.0 1.8 1 1 1 2 2 2 1 MULE transposase domain PINIT PF14324.1 ESA07917.1 - 0.039 14.0 0.1 0.093 12.8 0.0 1.6 2 0 0 2 2 2 0 PINIT domain Hormone_2 PF00123.15 ESA07919.1 - 0.068 13.0 0.1 10 6.0 0.0 2.2 2 0 0 2 2 2 0 Peptide hormone Pkinase_Tyr PF07714.12 ESA07920.1 - 4.5e-12 45.5 0.0 5.5e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07920.1 - 2.1e-10 40.1 0.0 3e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA07922.1 - 1.8e-13 50.2 0.2 2.6e-13 49.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07922.1 - 1.1e-10 40.9 0.0 1.5e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase HMG_box_2 PF09011.5 ESA07923.1 - 5.5e-05 23.4 0.1 9.4e-05 22.7 0.1 1.3 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.14 ESA07923.1 - 0.0032 17.7 0.7 0.0069 16.6 0.5 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box DnaJ PF00226.26 ESA07924.1 - 2.3e-23 81.6 2.7 2.3e-23 81.6 1.9 1.6 2 0 0 2 2 2 1 DnaJ domain DUF342 PF03961.8 ESA07924.1 - 0.036 12.4 2.9 0.047 12.1 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GP41 PF00517.12 ESA07924.1 - 0.093 12.2 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Retroviral envelope protein zf-C3HC4_3 PF13920.1 ESA07925.1 - 0.00019 21.0 12.0 0.00036 20.1 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) APG6 PF04111.7 ESA07925.1 - 0.00038 19.6 9.3 0.00038 19.6 6.4 7.2 1 1 3 7 7 7 2 Autophagy protein Apg6 zf-RING_6 PF14835.1 ESA07925.1 - 0.0014 18.3 4.3 0.0036 17.0 3.0 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 ESA07925.1 - 0.0033 17.1 15.0 0.0066 16.1 10.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA07925.1 - 0.0062 16.1 16.4 0.014 15.0 11.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA07925.1 - 0.056 13.4 16.8 0.034 14.1 10.1 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA07925.1 - 0.73 9.7 11.4 1.7 8.5 7.9 1.7 1 0 0 1 1 1 0 Ring finger domain MtrG PF04210.8 ESA07925.1 - 6.4 6.5 11.7 6.8 6.4 0.3 4.6 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G BTB PF00651.26 ESA07926.1 - 1.6e-12 47.4 0.3 4.2e-12 46.0 0.2 1.8 1 0 0 1 1 1 1 BTB/POZ domain VWA_2 PF13519.1 ESA07926.1 - 8e-09 35.8 0.0 1.4e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA07926.1 - 9.4e-08 31.9 0.2 2.2e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.1 ESA07926.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain BACK PF07707.10 ESA07926.1 - 0.44 10.4 8.1 0.15 11.8 1.2 3.2 3 1 1 4 4 4 0 BTB And C-terminal Kelch DUF2884 PF11101.3 ESA07927.1 - 0.12 11.7 1.2 0.69 9.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) UBN2_2 PF14227.1 ESA07928.1 - 0.032 13.7 0.1 0.1 12.1 0.1 1.8 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type FERM_N PF09379.5 ESA07928.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 FERM N-terminal domain Na_Ca_ex PF01699.19 ESA07933.1 - 1.2e-39 135.1 32.1 5.7e-24 84.3 5.7 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DUF2627 PF11118.3 ESA07933.1 - 0.052 13.6 0.0 0.27 11.3 0.0 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Sdh_cyt PF01127.17 ESA07933.1 - 0.82 9.5 10.7 2.7 7.8 1.4 3.6 2 1 1 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit BTB PF00651.26 ESA07935.1 - 6e-17 61.6 0.1 1.5e-13 50.6 0.0 3.3 1 1 1 2 2 2 2 BTB/POZ domain EAF PF09816.4 ESA07936.1 - 1.2e-05 25.1 0.6 2.3e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Tcf25 PF04910.9 ESA07937.1 - 8.9e-90 301.2 7.7 1.5e-89 300.5 5.3 1.3 1 0 0 1 1 1 1 Transcriptional repressor TCF25 DUF2984 PF11203.3 ESA07937.1 - 0.14 12.2 0.2 0.34 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2984) Spb1_C PF07780.7 ESA07938.1 - 1.4e-71 240.3 38.1 1.4e-71 240.3 26.4 4.1 2 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.14 ESA07938.1 - 1.7e-54 184.5 0.5 4e-54 183.3 0.0 1.9 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.3 ESA07938.1 - 7.5e-47 158.7 16.7 7.5e-47 158.7 11.6 5.8 3 1 1 5 5 5 1 Domain of unknown function (DUF3381) Acyl-CoA_ox_N PF14749.1 ESA07939.1 - 1.6e-13 51.0 0.1 1.9e-13 50.7 0.1 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal DDE_3 PF13358.1 ESA07940.1 - 2.1e-05 24.2 0.0 4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease CBM_19 PF03427.8 ESA07944.1 - 0.00027 20.6 3.6 0.0012 18.6 0.2 2.5 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) CBM_14 PF01607.19 ESA07944.1 - 2.6 8.0 9.5 5.7 6.9 1.0 2.8 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain Cwf_Cwc_15 PF04889.7 ESA07945.1 - 1.4e-69 234.4 32.8 4.6e-69 232.8 22.7 1.6 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein CAF-1_p150 PF11600.3 ESA07945.1 - 2.6 7.3 25.1 4.7 6.5 17.4 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PBP_sp32 PF07222.7 ESA07945.1 - 3.1 6.9 13.7 4.6 6.3 9.5 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 SprA-related PF12118.3 ESA07945.1 - 5.2 6.2 12.4 6.6 5.9 8.6 1.1 1 0 0 1 1 1 0 SprA-related family 4HBT PF03061.17 ESA07946.1 - 6.7e-25 87.0 2.5 1.1e-13 51.1 0.3 2.2 2 0 0 2 2 2 2 Thioesterase superfamily MaoC_dehydrat_N PF13452.1 ESA07946.1 - 0.0014 18.3 0.0 0.94 9.2 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase HbrB PF08539.6 ESA07947.1 - 2.9e-37 127.9 0.0 6.4e-37 126.8 0.0 1.5 1 1 0 1 1 1 1 HbrB-like Complex1_30kDa PF00329.14 ESA07948.1 - 3.1e-36 123.7 0.0 4.6e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.4 ESA07948.1 - 0.085 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Globin PF00042.17 ESA07948.1 - 0.16 12.3 0.0 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Globin Rad51 PF08423.6 ESA07949.1 - 1.7e-35 122.2 0.3 3.2e-35 121.2 0.2 1.4 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 ESA07949.1 - 1.5e-13 50.6 0.0 2.6e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESA07949.1 - 7e-10 38.4 0.1 1.1e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 KaiC RNA_pol_A_CTD PF03118.10 ESA07949.1 - 5.1e-08 32.2 1.0 1.1e-07 31.1 0.7 1.6 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain RecA PF00154.16 ESA07949.1 - 0.0024 16.9 2.9 0.039 13.0 2.0 2.1 1 1 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_C PF03796.10 ESA07949.1 - 0.0073 15.2 2.2 0.023 13.5 1.5 1.8 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_17 PF13207.1 ESA07949.1 - 0.1 13.4 0.0 2.6 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 ESA07949.1 - 0.13 12.3 1.2 0.69 10.0 0.8 2.2 1 1 0 1 1 1 0 AAA domain PfkB PF00294.19 ESA07949.1 - 0.17 10.9 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 pfkB family carbohydrate kinase DASH_Spc19 PF08287.6 ESA07950.1 - 3.2e-21 75.5 18.7 3.2e-21 75.5 13.0 1.9 1 1 1 2 2 2 1 Spc19 PLRV_ORF5 PF01690.12 ESA07950.1 - 1 8.4 12.9 1.4 7.9 8.9 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein NPV_P10 PF05531.7 ESA07950.1 - 2 8.6 9.4 1.2 9.3 0.1 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.1 ESA07950.1 - 2.8 8.3 26.6 6.4 7.1 0.1 4.1 3 1 1 4 4 4 0 Snapin/Pallidin DUF3994 PF13159.1 ESA07950.1 - 4.2 7.6 16.9 0.24 11.6 5.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3994) Reprolysin_3 PF13582.1 ESA07954.1 - 0.12 12.9 0.1 1.5 9.3 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 ESA07954.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like TIR PF01582.15 ESA07955.1 - 0.044 13.2 0.1 0.052 12.9 0.1 1.1 1 0 0 1 1 1 0 TIR domain PYRIN PF02758.11 ESA07955.1 - 0.05 13.2 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain RXT2_N PF08595.6 ESA07956.1 - 0.37 10.5 3.9 1 9.1 2.7 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.7 ESA07956.1 - 0.6 7.9 7.8 0.89 7.3 5.4 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA07956.1 - 1.4 6.8 6.4 2 6.3 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Upf2 PF04050.9 ESA07956.1 - 3.8 7.2 10.8 6 6.6 7.5 1.2 1 0 0 1 1 1 0 Up-frameshift suppressor 2 AIG1 PF04548.11 ESA07958.1 - 4.6e-07 29.1 0.2 4.6e-07 29.1 0.1 2.6 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 ESA07958.1 - 1.6e-06 27.3 0.3 3.9e-06 26.1 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 ESA07958.1 - 4.8e-06 26.5 0.2 4.8e-06 26.5 0.1 2.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase T2SE PF00437.15 ESA07958.1 - 0.00016 20.6 0.0 0.00033 19.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.12 ESA07958.1 - 0.00063 19.6 0.6 0.00063 19.6 0.4 3.8 2 2 1 3 3 2 1 Domain of unknown function DUF87 MobB PF03205.9 ESA07958.1 - 0.00082 19.0 0.1 0.0031 17.1 0.1 2.0 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 ESA07958.1 - 0.0017 18.5 0.0 0.0074 16.4 0.0 2.2 1 0 0 1 1 1 1 RNA helicase AAA_10 PF12846.2 ESA07958.1 - 0.0025 17.3 0.0 0.007 15.8 0.0 1.8 2 1 0 2 2 2 1 AAA-like domain DUF815 PF05673.8 ESA07958.1 - 0.0033 16.4 0.2 0.0074 15.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.22 ESA07958.1 - 0.0051 17.1 0.1 0.0051 17.1 0.1 3.1 2 2 1 3 3 2 1 ABC transporter RuvB_N PF05496.7 ESA07958.1 - 0.0064 15.5 0.1 0.081 11.9 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_29 PF13555.1 ESA07958.1 - 0.019 14.4 0.0 0.045 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.12 ESA07958.1 - 0.02 14.3 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.13 ESA07958.1 - 0.025 14.0 0.0 0.061 12.7 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Sigma54_activat PF00158.21 ESA07958.1 - 0.026 13.9 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.1 ESA07958.1 - 0.069 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 ESA07959.1 - 2e-06 27.1 0.0 2e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA07959.1 - 0.0094 15.0 0.0 0.0094 15.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase MIR PF02815.14 ESA07960.1 - 3.2e-10 39.8 4.3 1.4e-07 31.2 1.2 2.8 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA07960.1 - 6.2e-08 31.9 0.9 7.6e-06 25.0 0.1 2.1 1 1 1 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor RNase_H PF00075.19 ESA07961.1 - 5.3e-06 26.7 0.0 9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF836 PF05768.9 ESA07961.1 - 0.053 13.7 1.3 0.13 12.5 0.9 1.7 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) CR6_interact PF10147.4 ESA07963.1 - 0.0086 15.4 1.4 0.0086 15.4 1.0 2.0 2 0 0 2 2 2 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 TMF_TATA_bd PF12325.3 ESA07963.1 - 0.013 15.2 2.3 0.013 15.2 1.6 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Pro-NT_NN PF07421.6 ESA07963.1 - 0.018 14.5 1.7 0.07 12.6 0.1 2.3 2 1 1 3 3 3 0 Neurotensin/neuromedin N precursor DUF2458 PF10454.4 ESA07963.1 - 0.045 13.6 0.5 0.045 13.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) SpoIIID PF12116.3 ESA07963.1 - 0.052 13.4 0.1 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Stage III sporulation protein D Ribosomal_L31 PF01197.13 ESA07963.1 - 0.093 12.7 0.3 0.29 11.1 0.2 1.9 1 1 0 1 1 1 0 Ribosomal protein L31 TAFH PF07531.9 ESA07963.1 - 0.28 10.8 6.2 3.2 7.4 1.3 2.8 1 1 1 2 2 2 0 NHR1 homology to TAF Cluap1 PF10234.4 ESA07963.1 - 0.66 9.1 12.4 0.45 9.6 7.1 1.7 1 1 1 2 2 2 0 Clusterin-associated protein-1 Seryl_tRNA_N PF02403.17 ESA07963.1 - 3.7 7.6 12.3 4.1 7.4 0.8 2.4 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Bap31 PF05529.7 ESA07963.1 - 4.2 6.7 11.6 1.2 8.6 1.7 2.1 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Mg_trans_NIPA PF05653.9 ESA07965.1 - 2.8e-32 111.9 12.8 1.9e-17 63.2 2.6 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA07965.1 - 0.00023 21.3 3.2 0.00023 21.3 2.2 3.0 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA07965.1 - 0.0089 16.0 8.9 0.0089 16.0 6.2 2.9 3 1 0 3 3 3 1 EamA-like transporter family DUF2614 PF11023.3 ESA07965.1 - 0.47 10.2 7.7 7.2 6.4 2.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) PrgI PF12666.2 ESA07965.1 - 6.1 7.0 12.4 0.25 11.4 0.6 3.2 2 1 1 3 3 3 0 PrgI family protein DUF1798 PF08807.5 ESA07967.1 - 0.013 15.2 0.9 0.016 14.8 0.6 1.2 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) DDE_1 PF03184.14 ESA07969.1 - 0.001 18.2 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Mac PF12464.3 ESA07969.1 - 0.06 13.3 0.1 0.071 13.1 0.1 1.3 1 0 0 1 1 1 0 Maltose acetyltransferase Phage_int_SAM_5 PF13102.1 ESA07972.1 - 0.036 14.0 1.1 0.63 10.0 0.1 2.3 1 1 1 2 2 2 0 Phage integrase SAM-like domain Phage_integrase PF00589.17 ESA07973.1 - 0.00034 20.3 0.5 0.00079 19.1 0.0 1.8 2 0 0 2 2 2 1 Phage integrase family Trp_dioxygenase PF03301.8 ESA07973.1 - 0.059 12.4 0.1 0.077 12.0 0.1 1.2 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase Kelch_4 PF13418.1 ESA07975.1 - 0.00029 20.5 8.9 0.0053 16.5 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA07975.1 - 0.0018 18.3 14.0 0.049 13.8 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Glycophorin_A PF01102.13 ESA07975.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A Kelch_3 PF13415.1 ESA07975.1 - 0.078 13.1 9.6 8.1 6.7 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain SKG6 PF08693.5 ESA07975.1 - 0.12 11.6 0.1 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_1 PF01344.20 ESA07975.1 - 0.23 11.0 6.3 14 5.3 0.1 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.1 ESA07976.1 - 3e-05 24.0 4.3 0.018 15.1 0.5 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Thermopsin PF05317.6 ESA07976.1 - 0.018 13.9 1.4 0.03 13.2 1.0 1.3 1 0 0 1 1 1 0 Thermopsin Kelch_4 PF13418.1 ESA07976.1 - 0.03 14.0 6.6 0.23 11.2 0.2 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA07976.1 - 7.3 6.2 12.6 18 4.9 1.3 3.9 4 1 0 4 4 4 0 Kelch motif FAM92 PF06730.6 ESA07977.1 - 0.0021 17.4 1.8 0.0024 17.2 1.2 1.0 1 0 0 1 1 1 1 FAM92 protein DUF3658 PF12395.3 ESA07979.1 - 0.032 13.8 0.6 0.032 13.8 0.4 2.7 3 1 0 3 3 3 0 Protein of unknown function PASTA PF03793.14 ESA07979.1 - 0.062 12.9 0.1 11 5.6 0.0 2.5 2 0 0 2 2 2 0 PASTA domain ZYG-11_interact PF05884.7 ESA07979.1 - 0.48 9.4 4.7 2.7 7.0 2.7 2.1 2 0 0 2 2 2 0 Interactor of ZYG-11 Filo_VP35 PF02097.10 ESA07979.1 - 4.4 6.3 10.4 0.22 10.6 3.2 1.7 2 0 0 2 2 2 0 Filoviridae VP35 FliJ PF02050.11 ESA07979.1 - 7.6 6.6 27.9 0.26 11.3 12.4 2.6 2 1 0 2 2 2 0 Flagellar FliJ protein UreF PF01730.11 ESA07980.1 - 1.3e-15 57.8 0.0 1.8e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 UreF Pkinase_Tyr PF07714.12 ESA07982.1 - 1.7e-32 112.5 0.0 2e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07982.1 - 8.3e-30 103.7 0.0 9.3e-30 103.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA07982.1 - 0.046 13.4 0.1 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA07982.1 - 0.081 11.9 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA07984.1 - 2.9e-21 75.4 6.4 2.3e-12 47.1 1.3 2.2 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.1 ESA07984.1 - 0.013 15.9 2.1 1.5 9.4 0.3 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA07984.1 - 0.023 14.6 5.1 2.5 8.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA07984.1 - 0.039 13.7 0.5 3.9 7.5 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA07984.1 - 0.05 13.2 3.8 0.23 11.1 2.6 2.0 1 1 0 1 1 1 0 TPR repeat TPR_12 PF13424.1 ESA07984.1 - 0.084 12.8 3.7 5 7.1 0.4 2.5 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA07984.1 - 0.1 12.4 0.5 3.1 7.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA07984.1 - 0.13 11.9 9.4 7.4 6.3 0.2 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA07984.1 - 0.28 11.0 5.4 1.5 8.7 0.3 2.8 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain Abhydrolase_3 PF07859.8 ESA07985.1 - 7e-17 61.7 0.0 7.9e-17 61.5 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA07985.1 - 0.019 13.6 0.1 0.064 11.8 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2424) HMG_box PF00505.14 ESA07986.1 - 1.7e-09 37.8 3.0 1.7e-09 37.8 2.1 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box Borrelia_REV PF03978.8 ESA07986.1 - 0.00021 21.0 3.6 0.04 13.6 0.2 2.3 2 0 0 2 2 2 2 Borrelia burgdorferi REV protein DUF4041 PF13250.1 ESA07986.1 - 0.0063 16.0 2.4 2.6 7.6 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4041) HMG_box PF00505.14 ESA07987.1 - 3.9e-06 27.0 0.3 1.1e-05 25.6 0.2 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box DNase_II PF03265.10 ESA07987.1 - 0.033 13.1 3.7 0.038 12.9 2.5 1.2 1 0 0 1 1 1 0 Deoxyribonuclease II APO_RNA-bind PF05634.6 ESA07987.1 - 1 8.5 4.4 1.4 8.0 0.9 2.0 1 1 1 2 2 2 0 APO RNA-binding Methyltransf_11 PF08241.7 ESA07988.1 - 2.2e-15 56.9 0.0 4.7e-15 55.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA07988.1 - 3.1e-13 49.7 0.0 3.6e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA07988.1 - 5.7e-12 45.4 0.0 3.8e-11 42.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA07988.1 - 2e-08 34.4 0.0 4.9e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA07988.1 - 2.3e-08 33.4 0.0 2.7e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA07988.1 - 3.7e-08 33.7 0.0 2.9e-07 30.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA07988.1 - 5.1e-08 33.4 0.0 1.3e-06 28.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA07988.1 - 1.3e-07 30.9 0.0 2.8e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_29 PF03141.11 ESA07988.1 - 0.00021 19.7 0.0 0.0024 16.3 0.0 1.9 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.15 ESA07988.1 - 0.00051 19.2 0.0 0.00092 18.3 0.0 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 ESA07988.1 - 0.0018 18.3 0.0 0.0021 18.1 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA07988.1 - 0.0036 17.3 0.0 0.022 14.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA07988.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase MTS PF05175.9 ESA07988.1 - 0.018 14.4 0.0 0.023 14.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain CheR PF01739.13 ESA07988.1 - 0.022 14.0 0.0 0.59 9.3 0.0 2.1 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain PCMT PF01135.14 ESA07988.1 - 0.033 13.7 0.0 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.8 ESA07988.1 - 0.071 12.4 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Transposase_21 PF02992.9 ESA07989.1 - 0.034 13.2 0.0 0.079 12.0 0.0 1.6 1 1 0 1 1 1 0 Transposase family tnp2 DehI PF10778.4 ESA07989.1 - 0.092 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Halocarboxylic acid dehydrogenase DehI Macoilin PF09726.4 ESA07989.1 - 5.2 5.2 8.8 6.9 4.8 6.1 1.1 1 0 0 1 1 1 0 Transmembrane protein FIVAR PF07554.8 ESA07989.1 - 9.5 6.5 12.1 3.5 7.9 0.5 3.4 3 0 0 3 3 3 0 Uncharacterised Sugar-binding Domain Mpp10 PF04006.7 ESA07989.1 - 10 4.3 16.5 13 3.9 11.5 1.2 1 0 0 1 1 1 0 Mpp10 protein Vac_ImportDeg PF09783.4 ESA07990.1 - 7.8e-30 103.6 2.7 1.2e-29 103.1 1.9 1.3 1 0 0 1 1 1 1 Vacuolar import and degradation protein MULE PF10551.4 ESA07991.1 - 1.6e-05 24.9 0.0 3.6e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain BTB PF00651.26 ESA07994.1 - 4e-12 46.0 3.0 5.8e-12 45.5 0.7 2.3 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA07994.1 - 3.8e-05 23.7 2.9 4.7e-05 23.4 0.0 2.7 3 1 0 3 3 3 1 TLD DUF3579 PF12112.3 ESA07994.1 - 0.042 13.7 0.7 7.7 6.5 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3579) BTB PF00651.26 ESA07995.1 - 8.9e-17 61.0 0.4 1.4e-16 60.4 0.1 1.5 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA07995.1 - 0.00017 21.3 0.4 0.00051 19.8 0.3 1.8 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF1515 PF07439.6 ESA07997.1 - 0.049 13.4 0.1 0.076 12.8 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) DUF1565 PF07602.6 ESA07997.1 - 0.056 12.5 0.9 0.064 12.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) Reo_sigmaC PF04582.7 ESA07997.1 - 0.067 12.3 0.5 0.074 12.2 0.3 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 ESA07997.1 - 0.34 11.0 4.0 0.51 10.4 2.8 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 ESA07997.1 - 0.86 9.4 5.4 1.7 8.4 3.4 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Pkinase_Tyr PF07714.12 ESA07998.1 - 5.6e-46 156.7 0.0 7.5e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07998.1 - 9.4e-43 146.2 0.1 1.2e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA07998.1 - 0.0019 17.9 0.0 0.004 16.9 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA07998.1 - 0.0027 16.8 0.0 0.0041 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA07998.1 - 0.0056 16.0 0.2 0.029 13.7 0.1 2.1 2 1 0 2 2 2 1 RIO1 family WaaY PF06176.6 ESA07998.1 - 0.0057 15.8 0.6 0.0089 15.2 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) NTP_transferase PF00483.18 ESA07998.1 - 0.083 12.1 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase Pkinase_Tyr PF07714.12 ESA07999.1 - 6.4e-48 163.0 0.0 1.2e-47 162.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA07999.1 - 3e-44 151.1 0.0 5.1e-44 150.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HMG_box PF00505.14 ESA07999.1 - 3e-06 27.3 0.5 6e-06 26.4 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box WaaY PF06176.6 ESA07999.1 - 0.00039 19.7 0.0 0.00097 18.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA07999.1 - 0.0023 17.6 0.4 0.085 12.5 0.2 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA07999.1 - 0.0024 17.2 0.1 0.0068 15.7 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA07999.1 - 0.0069 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SMRP1 PF15181.1 ESA08000.1 - 0.007 15.7 0.1 0.0075 15.6 0.1 1.1 1 0 0 1 1 1 1 Spermatid-specific manchette-related protein 1 Toxin_trans PF07952.7 ESA08000.1 - 0.0072 15.2 1.2 0.0078 15.1 0.9 1.2 1 0 0 1 1 1 1 Clostridium neurotoxin, Translocation domain DUF4619 PF15398.1 ESA08000.1 - 0.024 14.0 0.8 0.027 13.8 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) Phospholip_A2_3 PF09056.6 ESA08000.1 - 0.038 14.1 0.5 0.053 13.7 0.3 1.3 1 1 0 1 1 1 0 Prokaryotic phospholipase A2 DUF3942 PF13078.1 ESA08000.1 - 0.055 13.5 0.9 0.07 13.2 0.6 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3942) Ank_2 PF12796.2 ESA08001.1 - 6.7e-22 77.6 0.0 9.2e-10 38.7 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA08001.1 - 1.7e-18 66.5 3.4 7.8e-07 29.4 0.0 4.8 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 ESA08001.1 - 2.6e-14 52.1 0.2 1.5e-05 24.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 ESA08001.1 - 1.1e-10 41.4 0.3 3.6e-06 27.0 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA08001.1 - 1.8e-10 39.9 2.2 0.0018 18.3 0.0 5.8 6 0 0 6 6 6 1 Ankyrin repeat Pkinase_Tyr PF07714.12 ESA08002.1 - 2.3e-35 121.9 0.0 3.2e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08002.1 - 2.5e-32 112.0 0.0 4.3e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA08002.1 - 0.00032 20.5 0.3 0.24 11.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESA08002.1 - 0.12 11.4 0.4 0.21 10.6 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_Tnp_Tc3_2 PF01498.13 ESA08004.1 - 2e-14 53.3 2.2 3e-14 52.8 1.5 1.3 1 0 0 1 1 1 1 Transposase Myb_DNA-bind_3 PF12776.2 ESA08004.1 - 0.039 14.5 1.1 0.12 13.0 0.2 2.0 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain PBD PF00786.23 ESA08005.1 - 0.004 17.5 0.1 0.004 17.5 0.0 2.9 3 1 1 4 4 4 1 P21-Rho-binding domain DUF4419 PF14388.1 ESA08006.1 - 1.2e-70 238.1 1.0 1.3e-70 237.9 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) DUF2730 PF10805.3 ESA08007.1 - 0.071 12.8 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) APG6 PF04111.7 ESA08007.1 - 0.38 9.7 7.2 0.49 9.3 5.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 MtrG PF04210.8 ESA08007.1 - 0.48 10.1 3.8 0.56 9.9 0.3 2.4 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Myb_DNA-bind_4 PF13837.1 ESA08008.1 - 3.7e-06 26.9 1.7 9.5e-06 25.6 1.2 1.8 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA08008.1 - 0.16 12.6 3.1 0.14 12.8 0.7 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA08008.1 - 0.16 12.0 3.5 0.59 10.2 2.4 2.1 1 1 0 1 1 1 0 Myb-like DNA-binding domain NAD_kinase PF01513.16 ESA08009.1 - 5.8e-62 209.0 0.0 7.1e-62 208.7 0.0 1.0 1 0 0 1 1 1 1 ATP-NAD kinase Cys_Met_Meta_PP PF01053.15 ESA08011.1 - 9.8e-27 93.2 0.0 1e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Cys_Met_Meta_PP PF01053.15 ESA08012.1 - 1.7e-22 79.2 0.0 1.9e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF4187 PF13821.1 ESA08013.1 - 0.034 13.7 0.1 0.047 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Vhr1 PF04001.8 ESA08013.1 - 0.098 12.5 0.2 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Transcription factor Vhr1 Mid1 PF12929.2 ESA08014.1 - 7.5e-21 74.3 1.7 1.4e-20 73.4 1.2 1.4 1 1 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component AAA_10 PF12846.2 ESA08015.1 - 0.029 13.8 0.0 0.072 12.5 0.0 1.6 1 1 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 ESA08015.1 - 0.082 13.0 0.3 0.76 9.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase KaiC PF06745.8 ESA08015.1 - 0.082 12.0 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC PV-1 PF06637.6 ESA08018.1 - 0.009 14.6 1.9 0.0094 14.5 1.3 1.1 1 0 0 1 1 1 1 PV-1 protein (PLVAP) DUF3552 PF12072.3 ESA08018.1 - 0.028 13.6 7.6 0.034 13.3 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Apolipoprotein PF01442.13 ESA08018.1 - 0.034 13.6 1.1 0.04 13.4 0.7 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain MeMO_Hyd_G PF02964.11 ESA08018.1 - 0.094 12.6 0.3 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain ADK PF00406.17 ESA08018.1 - 0.11 12.3 1.1 0.14 12.0 0.8 1.1 1 0 0 1 1 1 0 Adenylate kinase RabGAP-TBC PF00566.13 ESA08019.1 - 1.9e-59 200.7 1.2 3.9e-59 199.6 0.8 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IFP_35_N PF07334.8 ESA08019.1 - 0.013 15.4 0.7 0.029 14.3 0.5 1.6 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus ATG16 PF08614.6 ESA08019.1 - 0.17 11.7 8.4 0.087 12.6 3.2 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) HlyD PF00529.15 ESA08019.1 - 0.38 9.9 5.6 0.64 9.2 3.9 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Vps51 PF08700.6 ESA08019.1 - 0.75 9.6 5.3 0.45 10.4 0.2 2.8 3 0 0 3 3 3 0 Vps51/Vps67 IncA PF04156.9 ESA08019.1 - 2.2 7.8 8.8 1.2 8.7 3.3 2.1 2 0 0 2 2 2 0 IncA protein DUF3375 PF11855.3 ESA08020.1 - 0.009 14.8 0.5 0.013 14.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3375) IFT43 PF15305.1 ESA08020.1 - 0.096 12.7 2.5 1.4 8.9 0.6 2.5 2 1 0 2 2 2 0 Intraflagellar transport protein 43 Ribosomal_L30_N PF08079.7 ESA08021.1 - 0.1 12.6 0.2 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain MgtE PF01769.11 ESA08022.1 - 9.1e-42 142.5 16.5 1.8e-22 80.0 2.9 3.1 3 0 0 3 3 3 2 Divalent cation transporter RRN7 PF11781.3 ESA08023.1 - 6.9e-05 22.2 0.7 0.00012 21.5 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 Coa1 PF08695.5 ESA08025.1 - 2.1e-30 104.6 0.0 2.2e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SprT-like PF10263.4 ESA08026.1 - 1.4e-40 138.5 3.7 1.6e-40 138.3 2.5 1.0 1 0 0 1 1 1 1 SprT-like family WLM PF08325.5 ESA08026.1 - 0.00011 22.1 2.8 0.00019 21.3 1.9 1.5 1 1 0 1 1 1 1 WLM domain Peptidase_M76 PF09768.4 ESA08026.1 - 0.033 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase M76 family CN_hydrolase PF00795.17 ESA08027.1 - 0.0034 16.7 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Hist_deacetyl PF00850.14 ESA08028.1 - 1.1e-51 175.9 0.0 1.3e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain S10_plectin PF03501.10 ESA08028.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Plectin/S10 domain Lung_7-TM_R PF06814.8 ESA08029.1 - 1.7e-73 247.2 17.2 2e-73 246.9 11.9 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.4 ESA08029.1 - 4.6e-06 26.0 3.1 4.6e-06 26.0 2.2 2.5 2 1 0 2 2 2 1 Rhodopsin-like GPCR transmembrane domain UPF0233 PF06781.7 ESA08029.1 - 2 8.1 8.0 6 6.5 0.5 3.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) UCH PF00443.24 ESA08033.1 - 8.3e-37 126.7 0.3 1.1e-36 126.3 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA08033.1 - 4e-16 59.3 0.0 6.1e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 ESA08033.1 - 4.8e-05 23.5 0.0 0.00017 21.7 0.0 2.0 1 0 0 1 1 1 1 MATH domain Pkinase_Tyr PF07714.12 ESA08034.1 - 2.1e-19 69.6 0.8 2.4e-14 53.0 0.1 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA08034.1 - 5.5e-19 68.3 1.7 1.4e-12 47.3 0.3 2.0 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA08034.1 - 0.0055 16.4 0.8 0.026 14.2 0.6 1.9 1 1 2 3 3 3 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA08034.1 - 0.012 14.8 0.1 0.018 14.2 0.0 1.3 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA08034.1 - 0.018 14.4 0.2 0.024 13.9 0.1 1.3 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA08034.1 - 0.037 13.1 0.1 0.054 12.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA08034.1 - 0.056 12.3 0.0 8 5.3 0.0 2.0 2 0 0 2 2 2 0 Kinase-like Sorting_nexin PF03700.8 ESA08036.1 - 0.07 13.2 0.1 0.08 13.0 0.1 1.1 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain SPC12 PF06645.8 ESA08039.1 - 4.7 7.0 5.5 15 5.4 3.8 1.9 1 1 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) HNOBA PF07701.9 ESA08040.1 - 0.03 13.5 0.1 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Heme NO binding associated Pkinase PF00069.20 ESA08042.1 - 9.9e-24 83.8 2.7 1.3e-23 83.4 1.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08042.1 - 4.3e-22 78.4 0.6 5.8e-21 74.7 0.4 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA08042.1 - 0.035 13.8 0.1 0.052 13.2 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA08044.1 - 7.9e-45 150.3 0.8 2.3e-09 37.5 0.1 5.2 4 1 1 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA08044.1 - 0.002 17.9 6.8 0.16 11.8 0.0 4.5 2 2 2 5 5 5 1 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA08044.1 - 0.0056 16.7 0.2 2.5 8.2 0.0 3.8 1 1 4 5 5 5 1 Predicted AdoMet-dependent methyltransferase Aurora-A_bind PF09041.5 ESA08044.1 - 0.45 10.3 3.7 1.7 8.4 0.0 3.4 4 1 1 5 5 5 0 Aurora-A binding UDPGT PF00201.13 ESA08045.1 - 3.4e-10 39.0 0.0 4.1e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA08045.1 - 0.07 12.7 0.2 0.11 12.1 0.1 1.4 1 1 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain B5 PF03484.10 ESA08045.1 - 0.11 12.3 0.9 0.23 11.3 0.6 1.7 1 1 0 1 1 1 0 tRNA synthetase B5 domain Protein_K PF12283.3 ESA08045.1 - 0.2 11.5 2.4 0.6 10.0 1.7 1.8 1 1 0 1 1 1 0 Bacteriophage protein K adh_short PF00106.20 ESA08046.1 - 1.5e-16 60.7 0.0 1.3e-15 57.6 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA08046.1 - 3.7e-05 23.6 0.0 0.0021 17.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA08046.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 KR domain SH3_3 PF08239.6 ESA08047.1 - 0.024 14.8 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial SH3 domain BTB PF00651.26 ESA08049.1 - 8.8e-08 32.1 1.4 8.5e-07 28.9 0.2 2.5 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA08049.1 - 5e-06 26.6 0.1 8.8e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 SPRY domain ubiquitin PF00240.18 ESA08050.1 - 2.8e-25 87.4 0.3 4.7e-25 86.7 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA08050.1 - 1.4e-13 50.2 0.4 3e-13 49.2 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like GABP-alpha PF11620.3 ESA08050.1 - 0.00066 19.6 0.1 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 GA-binding protein alpha chain DUF2407 PF10302.4 ESA08050.1 - 0.00087 19.4 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain PARP PF00644.15 ESA08050.1 - 0.0014 18.0 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ubiquitin_2 PF14560.1 ESA08050.1 - 0.0025 18.0 0.0 0.0051 17.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain UN_NPL4 PF11543.3 ESA08050.1 - 0.027 14.7 0.0 0.061 13.5 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 DUF3990 PF13151.1 ESA08050.1 - 0.079 12.3 0.3 0.19 11.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Aminotran_1_2 PF00155.16 ESA08051.1 - 6.1e-65 219.5 0.0 6.8e-65 219.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II ABC2_membrane_3 PF12698.2 ESA08051.1 - 0.0047 16.0 2.2 0.0076 15.3 1.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Cys_Met_Meta_PP PF01053.15 ESA08051.1 - 0.046 11.9 0.0 0.094 10.9 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Shugoshin_C PF07557.6 ESA08054.1 - 0.0032 16.9 1.0 0.0056 16.1 0.1 1.8 2 0 0 2 2 2 1 Shugoshin C terminus AAA_19 PF13245.1 ESA08055.1 - 0.025 14.3 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 ESA08055.1 - 0.054 12.3 0.0 0.09 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.1 ESA08055.1 - 0.096 12.5 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain eIF-5_eIF-2B PF01873.12 ESA08057.1 - 0.05 13.2 0.1 0.05 13.2 0.1 1.8 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DUF2439 PF10382.4 ESA08057.1 - 0.088 13.0 2.3 9.5 6.5 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) XisH PF08814.5 ESA08057.1 - 0.13 12.2 2.0 0.34 10.9 0.4 2.0 2 0 0 2 2 2 0 XisH protein zinc_ribbon_2 PF13240.1 ESA08057.1 - 1.5 8.4 5.3 3.7 7.1 3.7 1.7 1 0 0 1 1 1 0 zinc-ribbon domain Inositol_P PF00459.20 ESA08059.1 - 8.1e-35 120.4 0.5 2.5e-26 92.5 0.1 2.2 1 1 1 2 2 2 2 Inositol monophosphatase family DUF605 PF04652.11 ESA08060.1 - 0.00017 21.0 6.5 0.00018 21.0 4.5 1.0 1 0 0 1 1 1 1 Vta1 like DUF3899 PF13038.1 ESA08060.1 - 0.066 13.3 0.1 0.066 13.3 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) FAM195 PF14799.1 ESA08060.1 - 7 6.5 16.1 1.2 9.0 6.7 2.2 2 0 0 2 2 2 0 FAM195 family Pkinase_Tyr PF07714.12 ESA08061.1 - 0.0012 18.0 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08061.1 - 0.023 13.8 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain ubiquitin PF00240.18 ESA08062.1 - 2.5e-31 106.8 0.4 4e-31 106.2 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA08062.1 - 7.8e-17 60.7 0.2 1.3e-16 59.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA08062.1 - 9.8e-06 25.7 0.1 3.2e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain PARP PF00644.15 ESA08062.1 - 0.0061 16.0 0.1 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Rad60-SLD_2 PF13881.1 ESA08062.1 - 0.017 14.9 0.0 0.13 12.1 0.0 2.3 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like PTS_2-RNA PF01885.11 ESA08062.1 - 0.13 11.5 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Pkinase_Tyr PF07714.12 ESA08063.1 - 1.4e-42 145.6 0.0 2.2e-42 144.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08063.1 - 7.5e-37 126.8 0.1 2.4e-36 125.2 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain SMP PF04927.7 ESA08064.1 - 0.6 10.1 8.0 5 7.1 0.8 2.3 2 0 0 2 2 2 0 Seed maturation protein Col_cuticle_N PF01484.12 ESA08066.1 - 0.085 12.5 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain C2 PF00168.25 ESA08067.1 - 6.1e-32 109.3 0.1 9.9e-15 54.1 0.0 3.2 3 0 0 3 3 3 2 C2 domain Ricin_B_lectin PF00652.17 ESA08067.1 - 3.6e-10 39.9 0.2 0.00094 19.2 0.0 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 ESA08067.1 - 1.8e-08 34.6 4.6 6.7e-06 26.4 0.3 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like SpoVIF PF14069.1 ESA08068.1 - 0.039 13.6 3.3 0.051 13.3 2.3 1.3 1 1 0 1 1 1 0 Stage VI sporulation protein F DUF4558 PF15104.1 ESA08068.1 - 0.061 13.2 0.8 0.068 13.0 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4558) DnaB PF00772.16 ESA08068.1 - 0.11 12.3 1.2 0.14 12.0 0.8 1.4 1 1 0 1 1 1 0 DnaB-like helicase N terminal domain NmrA PF05368.8 ESA08069.1 - 3.2e-39 134.5 0.2 3.9e-39 134.2 0.1 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA08069.1 - 1.8e-12 47.6 0.0 2.6e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 ESA08069.1 - 2.2e-06 26.9 0.1 3e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 ESA08069.1 - 2.8e-05 22.9 0.0 3.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ESA08069.1 - 0.00012 22.0 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 ESA08069.1 - 0.00025 20.5 0.1 0.00035 20.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 ESA08069.1 - 0.00045 20.1 0.1 0.00086 19.2 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.5 ESA08069.1 - 0.00078 19.1 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_Gly3P_dh_N PF01210.18 ESA08069.1 - 0.036 13.8 0.1 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 ESA08069.1 - 0.039 14.3 0.0 0.07 13.5 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 ESA08069.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F-box-like PF12937.2 ESA08070.1 - 0.11 12.2 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 F-box-like Nt_Gln_amidase PF09764.4 ESA08072.1 - 2.5e-35 121.4 4.5 2.9e-35 121.2 3.2 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase HTH_Tnp_Tc5 PF03221.11 ESA08073.1 - 0.064 13.0 1.1 0.74 9.6 0.3 2.0 1 1 1 2 2 2 0 Tc5 transposase DNA-binding domain EI24 PF07264.6 ESA08074.1 - 2.5e-09 36.9 3.4 0.00011 21.6 0.4 2.2 2 0 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) FA_desaturase_2 PF03405.9 ESA08074.1 - 0.00076 18.3 0.0 0.0015 17.3 0.0 1.4 1 0 0 1 1 1 1 Fatty acid desaturase CTNNBL PF08216.6 ESA08076.1 - 0.037 13.6 0.9 0.063 12.8 0.1 1.8 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear TetR_C_8 PF14278.1 ESA08076.1 - 6.7 7.1 8.5 5.7 7.3 0.5 3.3 2 1 1 3 3 3 0 Transcriptional regulator C-terminal region Tim54 PF11711.3 ESA08080.1 - 0.022 13.3 5.6 0.03 12.9 3.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Macoilin PF09726.4 ESA08080.1 - 0.12 10.5 8.2 0.13 10.4 5.7 1.0 1 0 0 1 1 1 0 Transmembrane protein Lin-8 PF03353.10 ESA08080.1 - 0.27 10.4 14.0 0.33 10.1 9.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.5 ESA08080.1 - 0.73 8.1 5.5 0.8 8.0 3.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2894 PF11445.3 ESA08080.1 - 0.9 9.7 4.7 1.2 9.3 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Menin PF05053.8 ESA08080.1 - 1 7.4 7.1 1.2 7.2 4.9 1.1 1 0 0 1 1 1 0 Menin Peptidase_S64 PF08192.6 ESA08080.1 - 1.1 7.4 13.9 1.3 7.3 9.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 Ebola_NP PF05505.7 ESA08080.1 - 2.3 6.1 13.6 2.8 5.9 9.4 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein PA26 PF04636.8 ESA08080.1 - 3 6.4 13.4 3.8 6.1 9.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF966 PF06136.8 ESA08080.1 - 5 6.4 11.9 6 6.1 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) AUX_IAA PF02309.11 ESA08083.1 - 0.26 11.0 2.8 0.32 10.6 1.9 1.1 1 0 0 1 1 1 0 AUX/IAA family Thg1C PF14413.1 ESA08084.1 - 0.042 13.5 0.4 0.075 12.7 0.3 1.4 1 0 0 1 1 1 0 Thg1 C terminal domain Thg1C PF14413.1 ESA08085.1 - 0.058 13.0 1.0 0.11 12.1 0.1 1.9 2 0 0 2 2 2 0 Thg1 C terminal domain NHR2 PF08788.6 ESA08085.1 - 0.08 12.4 1.0 1.7 8.1 0.0 2.9 3 0 0 3 3 3 0 NHR2 domain like EF1G PF00647.14 ESA08085.1 - 2.3 7.9 7.8 1.8 8.3 1.0 3.0 3 0 0 3 3 3 0 Elongation factor 1 gamma, conserved domain F-box-like PF12937.2 ESA08090.1 - 0.00031 20.4 0.9 0.00031 20.4 0.6 2.5 3 0 0 3 3 3 1 F-box-like Pkinase_Tyr PF07714.12 ESA08091.1 - 1.2e-19 70.4 0.0 4.8e-19 68.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08091.1 - 1.2e-19 70.5 0.4 4.5e-19 68.6 0.3 2.0 1 0 0 1 1 1 1 Protein kinase domain DUF3740 PF12548.3 ESA08091.1 - 0.0061 16.8 14.1 0.17 12.1 1.3 3.5 3 0 0 3 3 3 2 Sulfatase protein DUF4111 PF13427.1 ESA08091.1 - 0.13 12.0 1.6 18 5.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4111) APH PF01636.18 ESA08091.1 - 0.22 11.2 0.1 0.37 10.4 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2789 PF10982.3 ESA08091.1 - 1.1 9.2 4.4 12 5.9 0.0 4.1 4 2 1 5 5 5 0 Protein of unknown function (DUF2789) DUF4413 PF14372.1 ESA08091.1 - 2.1 8.3 13.9 1.9 8.5 0.8 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) DUF2411 PF10304.4 ESA08092.1 - 0.017 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2411) Pkinase PF00069.20 ESA08093.1 - 6.9e-15 54.9 0.1 7.9e-15 54.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08093.1 - 1.3e-14 53.9 0.0 1.6e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3544 PF12064.3 ESA08094.1 - 0.059 13.1 0.2 0.087 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3544) Sterile PF03015.14 ESA08094.1 - 0.33 11.2 4.0 1.5 9.0 0.0 2.4 1 1 1 2 2 2 0 Male sterility protein CBM_20 PF00686.14 ESA08095.1 - 0.0021 17.6 0.0 0.0046 16.5 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain DUF4278 PF14105.1 ESA08095.1 - 0.026 14.4 0.1 0.067 13.1 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) Ribosomal_L10 PF00466.15 ESA08096.1 - 0.056 13.3 0.2 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L10 DUF4272 PF14094.1 ESA08096.1 - 0.091 11.7 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) Tet_JBP PF12851.2 ESA08097.1 - 0.013 14.7 0.2 0.024 13.9 0.1 1.4 1 1 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily Gemini_BL1 PF00845.14 ESA08097.1 - 0.021 14.1 1.3 0.023 14.0 0.9 1.2 1 1 0 1 1 1 0 Geminivirus BL1 movement protein YebO PF13974.1 ESA08097.1 - 1.4 8.7 5.0 2.5 7.9 3.4 1.4 1 0 0 1 1 1 0 YebO-like protein Sel1 PF08238.7 ESA08098.1 - 1.1e-100 327.8 34.2 8.7e-13 48.4 0.1 10.5 10 1 0 10 10 10 9 Sel1 repeat TPR_6 PF13174.1 ESA08098.1 - 9e-23 79.1 13.4 0.18 12.3 0.0 10.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.1 ESA08098.1 - 7.3e-20 69.4 22.7 0.12 12.6 0.0 11.3 8 3 1 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08098.1 - 4.9e-16 58.1 34.4 0.0013 18.2 1.9 8.0 2 2 6 8 8 8 8 TPR repeat MIT PF04212.13 ESA08098.1 - 4.3e-09 36.1 15.7 0.59 10.0 0.2 7.8 6 3 2 8 8 8 3 MIT (microtubule interacting and transport) domain CitT PF12431.3 ESA08098.1 - 2.7e-07 30.4 0.0 15 5.7 0.0 8.0 9 0 0 9 9 9 0 Transcriptional regulator TPR_16 PF13432.1 ESA08098.1 - 3e-07 30.9 2.1 16 6.2 0.0 7.0 4 2 4 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08098.1 - 9.4e-07 28.6 20.2 0.5 10.3 0.4 7.7 3 3 6 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA08098.1 - 2.3e-05 24.6 5.3 30 5.0 0.0 7.4 7 2 1 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA08098.1 - 3.4e-05 23.2 52.9 2 8.1 0.1 14.2 15 2 2 17 17 16 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA08098.1 - 0.0004 20.0 54.4 1.7 8.7 0.2 13.5 14 2 2 16 16 16 4 Tetratricopeptide repeat DUF3674 PF12426.3 ESA08098.1 - 0.0015 17.8 10.7 11 5.5 0.2 7.2 7 0 0 7 7 7 1 RNA dependent RNA polymerase ELYS PF13934.1 ESA08098.1 - 0.0037 17.0 2.6 1.9 8.1 0.0 3.8 1 1 3 4 4 4 1 Nuclear pore complex assembly DUF2209 PF09974.4 ESA08098.1 - 0.34 10.9 2.1 11 6.1 0.0 3.7 3 1 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2209) DUF4354 PF14263.1 ESA08100.1 - 0.041 13.5 0.3 0.055 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) V-SNARE_C PF12352.3 ESA08101.1 - 0.1 12.7 3.1 0.84 9.7 0.4 3.0 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Sorb PF02208.11 ESA08102.1 - 0.07 12.5 0.0 0.26 10.6 0.0 2.0 1 0 0 1 1 1 0 Sorbin homologous domain YfhO PF09586.5 ESA08102.1 - 0.24 9.3 8.9 0.31 9.0 6.2 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Fis1_TPR_C PF14853.1 ESA08103.1 - 7.1e-06 25.8 0.6 4.1e-05 23.3 0.4 2.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat DnaJ PF00226.26 ESA08103.1 - 0.00052 19.6 0.6 0.0037 16.9 0.0 2.8 2 0 0 2 2 2 1 DnaJ domain Apc3 PF12895.2 ESA08103.1 - 0.0019 18.3 17.5 0.038 14.1 0.4 4.2 2 1 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA08103.1 - 0.0072 16.6 8.7 0.062 13.6 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA08103.1 - 0.011 15.5 5.1 0.063 13.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08103.1 - 1.6 8.4 14.6 2.3 7.9 0.1 4.4 3 1 2 5 5 5 0 TPR repeat Sel1 PF08238.7 ESA08104.1 - 1.4e-131 426.0 77.7 8.1e-13 48.5 1.2 13.0 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA08104.1 - 5.4e-11 42.1 37.7 0.79 10.3 0.1 11.2 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_17 PF13431.1 ESA08104.1 - 7.5e-07 28.8 42.1 1.6 9.1 0.1 12.6 11 1 1 12 12 12 3 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA08104.1 - 0.00078 19.1 19.8 63 3.4 0.0 10.2 11 1 1 12 12 12 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA08104.1 - 0.0022 18.0 10.1 15 5.7 0.1 6.9 2 2 7 10 10 10 0 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA08104.1 - 0.0029 17.6 0.0 44 4.1 0.0 5.3 3 2 2 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain MIT PF04212.13 ESA08104.1 - 0.0032 17.2 47.3 6.1 6.8 0.2 9.9 8 2 1 9 9 9 5 MIT (microtubule interacting and transport) domain HTH_16 PF12645.2 ESA08104.1 - 0.056 13.3 14.2 28 4.7 0.0 6.2 7 0 0 7 7 7 0 Helix-turn-helix domain ZipA_C PF04354.8 ESA08104.1 - 0.062 12.7 0.2 5.7 6.4 0.0 3.2 3 0 0 3 3 3 0 ZipA, C-terminal FtsZ-binding domain Glu_syn_central PF04898.9 ESA08104.1 - 4.1 6.5 10.3 1.5 7.9 0.0 4.6 4 1 2 6 6 6 0 Glutamate synthase central domain FA_desaturase PF00487.19 ESA08105.1 - 0.071 12.5 1.0 0.99 8.7 0.3 2.0 2 0 0 2 2 2 0 Fatty acid desaturase Sel1 PF08238.7 ESA08107.1 - 2.8e-36 123.1 12.0 5.3e-11 42.7 0.4 5.1 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA08107.1 - 0.0015 18.3 11.5 0.063 13.1 0.4 4.0 2 2 1 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA08107.1 - 0.0019 18.5 6.0 0.43 11.1 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08107.1 - 0.01 15.4 16.2 0.13 11.8 0.8 3.7 2 1 2 4 4 4 0 TPR repeat TPR_12 PF13424.1 ESA08107.1 - 0.044 13.7 14.7 2.2 8.2 0.7 4.9 1 1 4 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA08107.1 - 0.32 10.8 6.3 17 5.5 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat NSF PF02071.15 ESA08107.1 - 0.49 11.1 5.0 2.8e+02 2.9 0.1 5.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat DUF2989 PF11207.3 ESA08107.1 - 0.5 9.7 11.1 0.43 10.0 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2989) DUF4175 PF13779.1 ESA08108.1 - 0.88 7.1 11.3 1.2 6.7 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FAR1 PF03101.10 ESA08109.1 - 0.067 13.7 0.4 0.079 13.4 0.3 1.2 1 0 0 1 1 1 0 FAR1 DNA-binding domain zf-CSL PF05207.8 ESA08109.1 - 0.071 12.6 0.1 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 CSL zinc finger Endonuclea_NS_2 PF13930.1 ESA08109.1 - 0.36 10.8 3.7 0.53 10.3 2.5 1.3 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease YgbB PF02542.11 ESA08110.1 - 0.12 12.1 0.0 1.1 9.0 0.0 2.0 2 0 0 2 2 2 0 YgbB family Pkinase_Tyr PF07714.12 ESA08112.1 - 2.6e-07 30.0 0.1 3.1e-07 29.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08112.1 - 0.043 12.9 0.1 0.058 12.5 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain Albumin_I PF08027.6 ESA08112.1 - 0.12 12.0 0.3 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Albumin I PLDc PF00614.17 ESA08114.1 - 2e-16 59.1 1.8 2.4e-08 33.5 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 ESA08114.1 - 7.9e-11 41.7 4.9 1.9e-07 30.8 1.3 3.4 2 1 0 2 2 2 2 PLD-like domain SH3_7 PF12914.2 ESA08114.1 - 0.12 12.1 0.4 1.5 8.6 0.0 2.8 3 0 0 3 3 3 0 SH3 domain of SH3b2 type Vfa1 PF08432.5 ESA08115.1 - 2.4 8.1 12.5 5.5 6.9 8.6 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 OSTbeta PF15048.1 ESA08115.1 - 4.4 7.4 7.0 2.2 8.3 3.1 1.7 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein AA_permease_2 PF13520.1 ESA08117.1 - 2.3e-27 95.6 25.6 2.6e-27 95.4 17.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA08117.1 - 5.6e-06 24.9 26.5 4.1e-05 22.1 18.3 2.2 1 1 0 1 1 1 1 Amino acid permease Pox_A11 PF05061.8 ESA08117.1 - 0.027 13.5 0.1 0.047 12.7 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein TFIIF_beta PF02270.10 ESA08118.1 - 3e-31 109.2 0.9 3.7e-31 108.9 0.6 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit Tau95 PF09734.4 ESA08118.1 - 0.06 12.6 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HMG_box_2 PF09011.5 ESA08119.1 - 0.0012 19.2 0.8 0.0027 18.0 0.6 1.7 1 1 0 1 1 1 1 HMG-box domain TP6A_N PF04406.9 ESA08119.1 - 0.0026 17.3 0.4 0.0026 17.3 0.3 1.7 2 0 0 2 2 2 1 Type IIB DNA topoisomerase HMG_box PF00505.14 ESA08119.1 - 0.0038 17.4 1.9 0.008 16.4 1.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Pkinase PF00069.20 ESA08120.1 - 5.3e-58 196.2 0.0 6.9e-58 195.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08120.1 - 3.4e-27 95.1 0.0 4.5e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA08120.1 - 0.0024 16.8 0.0 0.0066 15.4 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 ESA08120.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ILVD_EDD PF00920.16 ESA08120.1 - 0.085 11.2 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Dehydratase family DUF4519 PF15012.1 ESA08121.1 - 0.11 12.4 0.5 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) FAD_binding_6 PF00970.19 ESA08124.1 - 5e-20 71.4 0.0 6.8e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.6 ESA08124.1 - 0.00026 20.9 0.0 0.00033 20.6 0.0 1.2 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain NAD_binding_1 PF00175.16 ESA08124.1 - 0.05 14.1 1.3 0.086 13.4 0.9 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain PBP5_C PF07943.8 ESA08124.1 - 0.097 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain Atg14 PF10186.4 ESA08125.1 - 0.016 14.1 2.4 0.02 13.8 1.7 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3348 PF11828.3 ESA08125.1 - 0.086 12.2 0.3 0.093 12.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Involucrin2 PF06994.6 ESA08125.1 - 3.1 7.8 6.7 2.4 8.1 1.5 2.5 1 1 1 2 2 2 0 Involucrin Rrn6 PF10214.4 ESA08127.1 - 4.2e-14 51.6 2.2 5.2e-14 51.3 1.5 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor GTP_CH_N PF12471.3 ESA08127.1 - 0.0044 16.6 0.0 0.0099 15.4 0.0 1.6 2 0 0 2 2 2 1 GTP cyclohydrolase N terminal IL1 PF00340.14 ESA08127.1 - 0.05 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Interleukin-1 / 18 Prenyltrans PF00432.16 ESA08129.1 - 0.095 12.2 4.7 0.19 11.3 3.2 1.5 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat Toxin_13 PF07822.6 ESA08129.1 - 5.7 6.9 6.9 8.5 6.3 0.1 2.3 2 1 0 2 2 2 0 Neurotoxin B-IV-like protein Sod_Fe_N PF00081.17 ESA08130.1 - 0.19 11.9 7.4 2.4 8.4 0.1 2.7 3 0 0 3 3 3 0 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF4275 PF14101.1 ESA08133.1 - 0.008 16.2 2.9 0.01 15.9 2.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4275) HMG_box_2 PF09011.5 ESA08133.1 - 0.021 15.1 3.5 0.021 15.1 1.5 1.8 2 0 0 2 2 2 0 HMG-box domain DUF1796 PF08795.5 ESA08133.1 - 0.022 14.3 1.6 0.026 14.1 0.6 1.5 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Lipase_GDSL_3 PF14606.1 ESA08133.1 - 0.057 13.1 0.9 0.14 11.9 0.1 1.8 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Trypan_PARP PF05887.6 ESA08136.1 - 0.086 12.6 1.9 0.096 12.5 1.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.7 ESA08136.1 - 2.9 7.1 8.3 3.8 6.8 5.7 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF2151 PF10221.4 ESA08138.1 - 2.4e-08 32.6 0.1 2.4e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Cell cycle and development regulator CemA PF03040.9 ESA08138.1 - 0.14 11.7 0.1 0.26 10.8 0.0 1.4 2 0 0 2 2 2 0 CemA family UBA PF00627.26 ESA08139.1 - 0.017 14.9 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 UBA/TS-N domain Herpes_UL95 PF03038.9 ESA08139.1 - 0.021 13.7 0.7 0.022 13.6 0.5 1.0 1 0 0 1 1 1 0 UL95 family DUF4584 PF15223.1 ESA08139.1 - 0.042 13.1 0.1 0.045 13.0 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4584) DnaG_DnaB_bind PF08278.6 ESA08139.1 - 0.13 12.5 1.0 0.26 11.4 0.4 1.6 1 1 1 2 2 2 0 DNA primase DnaG DnaB-binding WAK_assoc PF14380.1 ESA08139.1 - 0.13 12.7 0.2 0.16 12.4 0.1 1.2 1 0 0 1 1 1 0 Wall-associated receptor kinase C-terminal LRR_6 PF13516.1 ESA08140.1 - 1.4e-09 37.0 22.7 0.25 11.5 0.0 9.9 11 0 0 11 11 11 4 Leucine Rich repeat LRR_1 PF00560.28 ESA08140.1 - 1.2e-05 24.6 14.2 14 6.2 0.0 9.5 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_4 PF12799.2 ESA08140.1 - 0.00032 20.2 21.4 0.064 12.8 0.1 5.9 4 2 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESA08140.1 - 0.0056 16.6 13.6 9 7.0 0.2 7.5 8 0 0 8 8 8 1 Leucine rich repeat LRR_8 PF13855.1 ESA08140.1 - 0.017 14.8 16.6 1.2 8.9 0.0 5.6 4 3 1 5 5 5 0 Leucine rich repeat DUF4218 PF13960.1 ESA08141.1 - 0.018 14.4 0.2 0.021 14.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) SKI PF01202.17 ESA08143.1 - 0.0072 16.1 0.2 0.0084 15.9 0.1 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.1 ESA08143.1 - 0.017 15.4 0.5 0.046 14.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 ESA08143.1 - 0.035 13.9 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain BDHCT PF08072.6 ESA08143.1 - 0.54 10.4 0.2 0.54 10.4 0.1 2.3 2 0 0 2 2 2 0 BDHCT (NUC031) domain VASP_tetra PF08776.6 ESA08143.1 - 0.89 8.9 5.8 1.7 7.9 2.3 2.3 2 0 0 2 2 2 0 VASP tetramerisation domain BTB PF00651.26 ESA08144.1 - 4.3e-22 78.1 0.1 2.2e-15 56.5 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain TLD PF07534.11 ESA08144.1 - 1.9e-11 44.0 7.6 1.9e-08 34.3 3.0 2.5 2 0 0 2 2 2 2 TLD BACK PF07707.10 ESA08144.1 - 0.00083 19.1 0.2 0.31 10.9 0.0 4.3 4 0 0 4 4 4 1 BTB And C-terminal Kelch HTH_WhiA PF02650.9 ESA08144.1 - 0.061 13.7 1.6 3.9 7.9 0.0 2.8 2 0 0 2 2 2 0 WhiA C-terminal HTH domain Multi_ubiq PF14452.1 ESA08145.1 - 0.041 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Multiubiquitin DUF3989 PF13150.1 ESA08147.1 - 0.1 12.0 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) MRC1 PF09444.5 ESA08148.1 - 0.027 14.7 7.8 0.31 11.3 5.4 2.1 2 0 0 2 2 2 0 MRC1-like domain Spindle_Spc25 PF08234.7 ESA08150.1 - 0.041 13.8 2.8 0.19 11.7 0.0 2.7 1 1 2 3 3 3 0 Chromosome segregation protein Spc25 IBN_N PF03810.14 ESA08151.1 - 0.0042 16.9 2.4 0.0067 16.3 1.6 1.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain RNA_pol_I_TF PF04090.7 ESA08151.1 - 0.32 10.2 2.5 0.32 10.2 1.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific initiation factor Mago_nashi PF02792.9 ESA08152.1 - 5.1e-11 42.4 1.6 3e-10 39.9 1.1 1.8 1 1 0 1 1 1 1 Mago nashi protein Claudin_3 PF06653.6 ESA08153.1 - 6.1 6.5 16.9 0.1 12.3 6.5 1.8 2 0 0 2 2 2 0 Tight junction protein, Claudin-like F-box-like PF12937.2 ESA08154.1 - 1.3e-06 28.0 0.4 5.8e-06 25.9 0.2 2.2 2 0 0 2 2 2 1 F-box-like ETX_MTX2 PF03318.8 ESA08155.1 - 1.2e-06 28.2 7.6 1.8e-06 27.6 5.3 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.15 ESA08155.1 - 4.6e-06 25.8 2.5 6.6e-06 25.3 1.7 1.1 1 0 0 1 1 1 1 Aerolysin toxin RicinB_lectin_2 PF14200.1 ESA08155.1 - 0.002 18.4 0.1 0.0061 16.9 0.1 1.9 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like G6PD_C PF02781.11 ESA08155.1 - 0.043 12.6 0.2 0.075 11.8 0.2 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, C-terminal domain Phage_P2_GpU PF06995.6 ESA08155.1 - 0.044 13.1 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Phage P2 GpU DUF1027 PF06265.6 ESA08156.1 - 0.038 13.8 0.9 1.4 8.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) Redoxin PF08534.5 ESA08157.1 - 2.1e-24 85.6 0.0 2.4e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 ESA08157.1 - 3.8e-11 42.7 0.0 4.5e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family HMG_box PF00505.14 ESA08158.1 - 4.3e-11 42.9 0.7 7.3e-11 42.1 0.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box YhfZ_C PF14503.1 ESA08158.1 - 0.011 15.0 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 0 YhfZ C-terminal domain HMG_box_2 PF09011.5 ESA08158.1 - 0.015 15.6 0.1 0.015 15.6 0.1 1.5 2 0 0 2 2 2 0 HMG-box domain MAT_Alpha1 PF04769.7 ESA08158.1 - 0.027 13.7 0.4 0.056 12.7 0.1 1.6 1 1 0 1 1 1 0 Mating-type protein MAT alpha 1 F-box-like PF12937.2 ESA08159.1 - 0.00048 19.7 4.1 0.0005 19.7 0.3 2.8 2 0 0 2 2 2 1 F-box-like PRAI PF00697.17 ESA08161.1 - 0.00093 18.7 0.1 0.00098 18.7 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase HOOK PF05622.7 ESA08162.1 - 0.032 12.0 0.1 0.031 12.0 0.1 1.1 1 0 0 1 1 1 0 HOOK protein ArsD PF06953.6 ESA08162.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD DUF2414 PF10309.4 ESA08163.1 - 0.06 13.0 0.5 0.084 12.5 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2414) CD45 PF12567.3 ESA08163.1 - 0.58 10.0 3.8 2.7 7.9 0.7 2.3 2 0 0 2 2 2 0 Leukocyte receptor CD45 zf-BED PF02892.10 ESA08165.1 - 0.0008 19.1 1.8 0.0012 18.5 1.3 1.3 1 0 0 1 1 1 1 BED zinc finger zf-U11-48K PF05253.7 ESA08165.1 - 0.063 13.0 0.3 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger zf-met2 PF12907.2 ESA08165.1 - 0.1 12.6 0.3 0.17 11.9 0.2 1.3 1 0 0 1 1 1 0 Zinc-binding FYRC PF05965.9 ESA08165.1 - 0.11 12.2 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 F/Y rich C-terminus OrfB_Zn_ribbon PF07282.6 ESA08165.1 - 0.14 11.8 1.3 0.28 10.8 0.9 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Sgf11 PF08209.6 ESA08165.1 - 0.4 10.0 1.8 2.1 7.7 1.3 1.9 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) Dimer_Tnp_hAT PF05699.9 ESA08166.1 - 4.5e-17 61.4 0.0 7.7e-17 60.6 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region V_ATPase_I PF01496.14 ESA08168.1 - 8.7e-299 992.7 0.1 9.9e-299 992.5 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Angiomotin_C PF12240.3 ESA08168.1 - 0.025 14.1 3.7 0.12 11.8 2.6 2.0 1 1 0 1 1 1 0 Angiomotin C terminal Rogdi_lz PF10259.4 ESA08168.1 - 0.045 12.8 0.5 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein Uds1 PF15456.1 ESA08168.1 - 0.066 13.2 1.9 7.1 6.6 0.2 2.3 2 0 0 2 2 2 0 Up-regulated During Septation PilJ PF13675.1 ESA08168.1 - 0.18 12.1 1.6 1.7 9.0 0.0 2.5 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ada3 PF10198.4 ESA08168.1 - 0.96 9.2 4.2 21 4.8 0.2 3.1 3 0 0 3 3 3 0 Histone acetyltransferases subunit 3 VHS PF00790.14 ESA08169.1 - 1e-42 145.1 2.0 6.1e-42 142.6 0.0 2.7 3 1 0 3 3 3 1 VHS domain GAT PF03127.9 ESA08169.1 - 1.4e-19 69.9 1.9 2.2e-19 69.2 0.3 2.1 2 0 0 2 2 2 1 GAT domain DUF3452 PF11934.3 ESA08169.1 - 0.0046 16.2 0.0 0.0099 15.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) SPOUT_MTase_2 PF14419.1 ESA08169.1 - 0.11 11.7 0.1 0.19 10.9 0.1 1.4 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP DUF1108 PF06531.6 ESA08169.1 - 0.12 12.5 0.7 0.39 10.9 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) AAA_10 PF12846.2 ESA08169.1 - 0.17 11.3 3.0 0.35 10.2 2.0 1.5 1 1 1 2 2 2 0 AAA-like domain Chromo_shadow PF01393.14 ESA08170.1 - 0.0019 17.9 0.1 0.0042 16.8 0.1 1.7 1 1 0 1 1 1 1 Chromo shadow domain DUF2971 PF11185.3 ESA08170.1 - 0.34 11.6 3.2 1.4 9.7 2.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2971) SPX PF03105.14 ESA08171.1 - 4.7e-18 65.9 16.1 2.7e-12 47.0 5.9 3.1 1 1 1 2 2 2 2 SPX domain CitMHS PF03600.11 ESA08172.1 - 1.9e-34 118.8 5.7 2.4e-34 118.4 4.0 1.0 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.10 ESA08172.1 - 1.5e-13 50.5 25.4 1.1e-12 47.7 8.2 2.2 2 0 0 2 2 2 2 Arsenical pump membrane protein ABC_membrane_2 PF06472.10 ESA08173.1 - 7.5e-109 363.2 3.5 1.1e-108 362.6 2.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESA08173.1 - 1.5e-19 70.6 0.0 3.3e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA08173.1 - 7.5e-05 22.8 0.1 0.00032 20.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 ESA08173.1 - 0.0027 18.0 0.5 0.017 15.4 0.3 2.3 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 ESA08173.1 - 0.0067 15.6 0.0 0.096 11.9 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESA08173.1 - 0.036 13.5 0.0 0.087 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.10 ESA08173.1 - 0.08 11.5 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_16 PF13191.1 ESA08173.1 - 0.096 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF919 PF06034.6 ESA08173.1 - 0.14 11.8 2.7 0.22 11.1 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF258 PF03193.11 ESA08173.1 - 0.15 11.2 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TPR_8 PF13181.1 ESA08174.1 - 3.8 7.5 7.7 7.1 6.6 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA08175.1 - 1.4e-23 82.7 35.3 3.9e-06 27.3 0.1 8.0 8 0 0 8 8 8 7 Sel1 repeat TPR_14 PF13428.1 ESA08175.1 - 1.5 9.6 4.3 4.4 8.2 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TENA_THI-4 PF03070.11 ESA08176.1 - 0.019 14.7 0.0 0.025 14.3 0.0 1.1 1 0 0 1 1 1 0 TENA/THI-4/PQQC family DUF308 PF03729.8 ESA08176.1 - 0.04 13.9 0.1 0.04 13.9 0.0 2.4 3 1 0 3 3 3 0 Short repeat of unknown function (DUF308) DUF3169 PF11368.3 ESA08176.1 - 0.046 12.9 0.5 0.087 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DUF161 PF02588.10 ESA08176.1 - 2.3 8.5 7.3 12 6.2 0.1 3.1 2 1 0 2 2 2 0 Uncharacterized BCR, YitT family COG1284 Thiolase_N PF00108.18 ESA08178.1 - 1.5e-06 27.4 0.1 1.6e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 ESA08178.1 - 0.0007 19.1 0.1 0.00076 19.0 0.1 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 ESA08178.1 - 0.01 15.5 0.2 0.018 14.6 0.1 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.6 ESA08178.1 - 0.065 11.6 0.2 0.08 11.3 0.1 1.1 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Git3 PF11710.3 ESA08179.1 - 3.7e-11 42.9 12.1 8.6e-11 41.7 8.4 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.6 ESA08179.1 - 2.4e-06 26.7 18.9 2.6e-06 26.5 12.3 1.4 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.16 ESA08179.1 - 2.7e-06 26.7 13.2 3.4e-06 26.4 9.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3_C PF11970.3 ESA08179.1 - 0.00042 20.0 0.9 0.00042 20.0 0.6 2.4 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF4083 PF13314.1 ESA08179.1 - 2.3 8.1 4.3 0.53 10.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) DUF4064 PF13273.1 ESA08179.1 - 2.7 8.1 9.0 0.092 12.8 1.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Sel1 PF08238.7 ESA08180.1 - 4.1e-40 135.3 20.9 4.6e-09 36.6 0.0 7.0 7 1 0 7 7 7 5 Sel1 repeat TPR_6 PF13174.1 ESA08180.1 - 0.026 14.9 8.8 1.2e+02 3.4 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Peptidase_C25_C PF03785.9 ESA08180.1 - 0.093 12.5 0.1 7.5 6.4 0.0 2.6 2 1 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain RPA_C PF08784.6 ESA08180.1 - 0.1 12.9 0.2 0.3 11.5 0.1 1.8 1 0 0 1 1 1 0 Replication protein A C terminal TPR_17 PF13431.1 ESA08180.1 - 0.11 12.7 20.5 12 6.4 0.2 7.2 5 3 2 7 7 7 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA08181.1 - 1.9e-28 99.2 0.0 2.2e-28 99.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08181.1 - 1.3e-25 90.0 0.1 1.4e-25 89.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA08181.1 - 0.00038 19.5 0.2 0.00051 19.1 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA08181.1 - 0.028 14.1 0.2 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA08181.1 - 0.059 12.7 0.2 0.083 12.2 0.1 1.2 1 0 0 1 1 1 0 RIO1 family DUF3117 PF11314.3 ESA08183.1 - 0.052 13.0 0.2 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3117) UQ_con PF00179.21 ESA08184.1 - 3.7e-45 152.7 0.1 4.9e-45 152.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESA08184.1 - 8.6e-05 22.2 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 ESA08184.1 - 0.003 17.4 0.0 0.0052 16.6 0.0 1.5 1 1 0 1 1 1 1 RWD domain CLTH PF10607.4 ESA08185.1 - 1.6e-34 118.7 0.1 6.3e-34 116.7 0.0 2.1 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.23 ESA08185.1 - 3e-24 85.4 0.1 7.5e-24 84.1 0.1 1.7 1 0 0 1 1 1 1 SPRY domain LisH PF08513.6 ESA08185.1 - 1.2e-05 24.9 0.1 3.1e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 LisH RRN3 PF05327.6 ESA08185.1 - 0.013 13.6 15.7 0.018 13.2 10.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.9 ESA08185.1 - 0.051 11.6 8.1 0.077 11.0 5.6 1.3 1 0 0 1 1 1 0 CDC45-like protein YlbD_coat PF14071.1 ESA08185.1 - 0.12 12.4 1.5 0.25 11.4 1.0 1.5 1 0 0 1 1 1 0 Putative coat protein PLDc_2 PF13091.1 ESA08186.1 - 3.5e-14 52.6 0.1 1.7e-08 34.2 0.1 3.2 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.17 ESA08186.1 - 1.4e-12 46.9 1.4 5.2e-05 22.8 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PNP_UDP_1 PF01048.15 ESA08188.1 - 4.5e-17 61.8 0.0 6.1e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily INCENP_N PF12178.3 ESA08188.1 - 0.1 12.1 0.1 0.45 10.0 0.0 2.1 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal Gly-zipper_OmpA PF13436.1 ESA08190.1 - 0.0009 18.8 3.8 0.0017 18.0 2.6 1.4 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain TraT PF05818.7 ESA08190.1 - 1.4 8.2 3.5 2.2 7.6 2.4 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein MNSV_P7B PF06692.6 ESA08191.1 - 0.054 13.2 1.2 0.12 12.2 0.4 1.9 1 1 1 2 2 2 0 Melon necrotic spot virus P7B protein ArsR PF09824.4 ESA08191.1 - 0.1 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 ArsR transcriptional regulator Sel1 PF08238.7 ESA08192.1 - 1e-75 248.4 43.0 9.8e-10 38.7 0.2 10.9 11 0 0 11 11 11 10 Sel1 repeat TPR_6 PF13174.1 ESA08192.1 - 0.00015 22.0 23.0 4.6 7.9 0.1 8.6 9 1 0 9 9 9 5 Tetratricopeptide repeat Pkinase PF00069.20 ESA08193.1 - 8.3e-22 77.5 0.1 9e-22 77.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08193.1 - 1e-18 67.3 0.0 1.1e-18 67.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA08193.1 - 0.019 14.7 0.2 0.095 12.4 0.3 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA08193.1 - 0.13 11.2 0.2 0.15 11.1 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA08193.1 - 0.13 11.5 0.2 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Methyltransf_31 PF13847.1 ESA08194.1 - 4.8e-32 110.6 0.2 7.7e-31 106.7 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08194.1 - 2.5e-17 63.1 0.0 6.4e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA08194.1 - 2.2e-12 47.5 0.0 4.4e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA08194.1 - 1.1e-11 44.3 0.0 2e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA08194.1 - 1.9e-11 44.1 0.0 4.8e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA08194.1 - 4.9e-11 42.5 0.0 8.1e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08194.1 - 1.2e-08 35.2 0.0 2.6e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESA08194.1 - 6.4e-07 29.1 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 ESA08194.1 - 2e-05 24.5 0.0 3.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA08194.1 - 6.3e-05 22.7 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase PrmA PF06325.8 ESA08194.1 - 0.01 14.9 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.6 ESA08194.1 - 0.021 13.5 0.1 0.045 12.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.12 ESA08194.1 - 0.084 11.9 0.0 0.73 8.8 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase Rho_Binding PF08912.6 ESA08194.1 - 0.09 13.0 0.5 0.19 12.0 0.4 1.5 1 0 0 1 1 1 0 Rho Binding FtsJ PF01728.14 ESA08194.1 - 0.11 12.5 0.0 0.3 11.0 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase MerR_1 PF13411.1 ESA08195.1 - 1.7e-19 69.3 1.4 3.1e-19 68.5 0.2 1.8 2 0 0 2 2 2 1 MerR HTH family regulatory protein MerR-DNA-bind PF09278.6 ESA08195.1 - 1.9e-14 53.7 2.3 3.1e-14 53.0 1.6 1.4 1 0 0 1 1 1 1 MerR, DNA binding MerR PF00376.18 ESA08195.1 - 1.5e-13 50.0 0.1 2.6e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 MerR family regulatory protein DUF4315 PF14193.1 ESA08195.1 - 0.00071 19.4 0.6 0.0086 15.9 0.0 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4315) Med15_fungi PF05397.7 ESA08195.1 - 0.023 14.6 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 15 DUF496 PF04363.7 ESA08195.1 - 0.034 13.9 1.1 0.5 10.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF496) DUF1836 PF08876.6 ESA08195.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1836) MerR-DNA-bind PF09278.6 ESA08196.1 - 1.4e-16 60.5 3.6 1.8e-16 60.2 2.5 1.1 1 0 0 1 1 1 1 MerR, DNA binding EcoEI_R_C PF08463.5 ESA08196.1 - 0.0012 18.7 0.2 0.0014 18.4 0.1 1.1 1 0 0 1 1 1 1 EcoEI R protein C-terminal Paramyx_P_V_C PF03210.8 ESA08196.1 - 0.023 14.5 0.0 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal Laminin_I PF06008.9 ESA08196.1 - 0.049 12.9 0.1 0.054 12.8 0.1 1.0 1 0 0 1 1 1 0 Laminin Domain I Filo_VP35 PF02097.10 ESA08196.1 - 0.062 12.4 0.0 0.071 12.2 0.0 1.0 1 0 0 1 1 1 0 Filoviridae VP35 TFCD_C PF12612.3 ESA08196.1 - 0.12 11.8 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal TLD PF07534.11 ESA08197.1 - 2.2e-09 37.4 1.3 2.2e-09 37.4 0.9 1.6 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA08197.1 - 0.0002 21.1 2.8 0.0013 18.5 0.9 2.8 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF1325 PF07039.6 ESA08198.1 - 2.1e-31 108.2 0.7 3.5e-31 107.5 0.5 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain Agenet PF05641.7 ESA08198.1 - 0.051 13.7 0.2 0.4 10.8 0.0 2.6 3 0 0 3 3 3 0 Agenet domain Syntaxin_2 PF14523.1 ESA08198.1 - 0.083 12.9 5.7 0.24 11.4 3.7 2.0 1 1 0 1 1 1 0 Syntaxin-like protein DUF3350 PF11830.3 ESA08198.1 - 0.23 11.5 1.2 0.35 10.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3350) AAA_35 PF14516.1 ESA08201.1 - 0.0017 17.0 0.1 0.0057 15.3 0.0 1.7 1 1 0 2 2 2 1 AAA-like domain AAA_14 PF13173.1 ESA08201.1 - 0.06 13.2 0.1 0.089 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA08201.1 - 0.066 13.1 0.0 0.088 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.22 ESA08202.1 - 2.5e-59 199.8 0.0 6.6e-59 198.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 ESA08202.1 - 1.7e-28 98.2 0.0 4.6e-28 96.8 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 ESA08202.1 - 5.9e-21 74.1 0.0 9.1e-20 70.3 0.0 2.4 1 1 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 ESA08202.1 - 2.8e-10 40.1 0.3 1.8e-09 37.6 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_IV PF03764.13 ESA08202.1 - 6.5e-08 32.1 0.0 8.8e-05 22.0 0.0 2.6 1 1 1 2 2 2 2 Elongation factor G, domain IV MMR_HSR1 PF01926.18 ESA08202.1 - 0.0066 16.3 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Sel1 PF08238.7 ESA08203.1 - 4.1e-60 198.8 32.5 1.7e-10 41.1 0.2 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA08203.1 - 0.0023 18.2 16.9 0.46 11.0 0.1 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat Tox-HDC PF15656.1 ESA08203.1 - 0.16 12.1 0.2 0.16 12.1 0.1 2.4 2 1 1 3 3 3 0 Toxin with a H, D/N and C signature TPR_17 PF13431.1 ESA08203.1 - 1.1 9.6 13.7 17 5.9 0.0 6.2 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA08203.1 - 7.7 7.3 7.3 27 5.5 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat RGS PF00615.14 ESA08204.1 - 2.9e-05 24.1 2.2 0.044 13.8 0.1 2.5 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF2892 PF11127.3 ESA08204.1 - 0.18 11.6 4.2 0.5 10.2 2.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2892) zf-BED PF02892.10 ESA08205.1 - 1.1e-08 34.6 0.8 2.2e-08 33.7 0.5 1.5 1 0 0 1 1 1 1 BED zinc finger zf-met2 PF12907.2 ESA08205.1 - 0.0077 16.1 0.4 0.012 15.5 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding DBD_Tnp_Hermes PF10683.4 ESA08205.1 - 0.027 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain Fibrinogen_BP PF08017.6 ESA08206.1 - 0.0014 16.8 0.0 0.0015 16.8 0.0 1.0 1 0 0 1 1 1 1 Fibrinogen binding protein HALZ PF02183.13 ESA08206.1 - 0.0095 15.6 11.9 18 5.1 0.2 6.0 1 1 7 8 8 8 3 Homeobox associated leucine zipper Sel1 PF08238.7 ESA08208.1 - 2.7e-08 34.1 3.2 0.00098 19.6 0.0 2.5 2 1 0 2 2 2 2 Sel1 repeat lci PF12197.3 ESA08208.1 - 0.017 14.6 2.9 0.46 10.1 0.2 2.3 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein MMtag PF10159.4 ESA08208.1 - 0.056 13.4 0.8 2.9 7.9 0.1 2.1 2 0 0 2 2 2 0 Kinase phosphorylation protein TRI5 PF06330.6 ESA08210.1 - 0.017 13.8 0.7 0.021 13.4 0.5 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) DUF4011 PF13195.1 ESA08210.1 - 0.025 14.5 2.6 0.035 14.1 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) LRR_8 PF13855.1 ESA08211.1 - 3e-10 39.7 0.7 4.3e-05 23.1 0.0 1.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 ESA08211.1 - 6.8e-10 38.3 0.5 3.6e-06 26.4 0.2 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA08211.1 - 4.2e-07 29.3 2.0 0.00046 19.9 0.0 2.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.28 ESA08211.1 - 1.1e-06 27.7 0.5 0.077 13.0 0.1 3.0 2 1 0 2 2 2 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA08211.1 - 6.4e-06 25.5 0.4 0.052 13.7 0.0 3.2 3 0 0 3 3 3 2 Leucine rich repeat FPL PF09758.4 ESA08212.1 - 3.1e-34 117.8 7.6 3.1e-34 117.8 5.3 2.7 3 1 0 3 3 3 1 Uncharacterised conserved protein RAI16-like PF10257.4 ESA08212.1 - 1.3e-05 24.3 0.6 2.4e-05 23.4 0.4 1.4 1 1 0 1 1 1 1 Retinoic acid induced 16-like protein F-box-like PF12937.2 ESA08214.1 - 5.7e-05 22.7 3.4 8e-05 22.2 1.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA08214.1 - 0.37 10.5 4.5 5.7 6.7 0.2 3.8 3 2 0 3 3 3 0 F-box domain STb_secrete PF09075.5 ESA08215.1 - 0.19 11.6 0.3 0.26 11.1 0.2 1.2 1 0 0 1 1 1 0 Heat-stable enterotoxin B, secretory DUF3818 PF12825.2 ESA08217.1 - 7.6e-13 47.8 1.4 1.9e-12 46.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) DUF4419 PF14388.1 ESA08217.1 - 0.06 12.5 0.1 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4419) Tenui_NCP PF04876.7 ESA08217.1 - 0.06 12.8 0.2 0.11 11.9 0.1 1.6 1 1 0 1 1 1 0 Tenuivirus major non-capsid protein RYDR_ITPR PF01365.16 ESA08217.1 - 0.1 11.7 1.1 5 6.2 0.3 2.3 2 0 0 2 2 2 0 RIH domain SDA1 PF05285.7 ESA08217.1 - 2.3 7.3 11.2 2.9 7.0 7.8 1.0 1 0 0 1 1 1 0 SDA1 Aldo_ket_red PF00248.16 ESA08218.1 - 3.7e-21 75.1 0.0 4.4e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1703 PF08011.6 ESA08219.1 - 9.3e-12 44.6 0.0 1.7e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1703) PPTA PF01239.17 ESA08220.1 - 0.14 11.5 1.5 0.24 10.8 1.0 1.4 1 0 0 1 1 1 0 Protein prenyltransferase alpha subunit repeat Pkinase_Tyr PF07714.12 ESA08221.1 - 3.7e-07 29.4 0.0 6.3e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08221.1 - 7e-07 28.6 0.1 1e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Dimer_Tnp_hAT PF05699.9 ESA08223.1 - 4.2e-18 64.7 0.1 4.4e-18 64.6 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA08224.1 - 0.0005 20.0 0.4 0.0028 17.6 0.0 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4413) DUF1539 PF07560.6 ESA08224.1 - 0.011 15.6 1.5 0.039 13.8 0.0 2.5 2 2 0 2 2 2 0 Domain of Unknown Function (DUF1539) Vasculin PF15337.1 ESA08225.1 - 0.074 13.5 0.1 0.25 11.8 0.1 1.9 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 Dna2 PF08696.6 ESA08226.1 - 0.045 13.0 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 DNA replication factor Dna2 GATA PF00320.22 ESA08227.1 - 0.071 12.4 0.1 0.071 12.4 0.0 2.6 3 0 0 3 3 3 0 GATA zinc finger FUR PF01475.14 ESA08227.1 - 0.14 12.0 0.7 0.32 10.9 0.5 1.6 1 0 0 1 1 1 0 Ferric uptake regulator family DUF4606 PF15379.1 ESA08227.1 - 1.2 9.2 4.3 1.8 8.6 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4606) Zn-ribbon_8 PF09723.5 ESA08227.1 - 5.4 7.0 13.1 0.31 11.0 0.3 3.6 4 0 0 4 4 4 0 Zinc ribbon domain rve PF00665.21 ESA08228.1 - 1.3e-07 31.7 0.0 1.8e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain RasGAP PF00616.14 ESA08230.1 - 0.059 13.0 0.8 0.12 12.0 0.2 1.6 1 1 1 2 2 2 0 GTPase-activator protein for Ras-like GTPase DUF4428 PF14471.1 ESA08230.1 - 0.34 10.6 10.8 0.51 10.1 1.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) UPF0547 PF10571.4 ESA08230.1 - 3.7 7.3 10.1 5.7 6.7 0.2 3.9 3 1 1 4 4 4 0 Uncharacterised protein family UPF0547 Sigma54_AID PF00309.15 ESA08231.1 - 0.039 13.4 0.1 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) NPR2 PF06218.6 ESA08231.1 - 0.095 11.3 4.1 0.1 11.2 2.8 1.0 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Syntaxin_2 PF14523.1 ESA08231.1 - 0.14 12.2 5.6 0.15 12.0 3.9 1.1 1 0 0 1 1 1 0 Syntaxin-like protein Spc24 PF08286.6 ESA08231.1 - 0.14 11.8 3.9 0.16 11.7 2.7 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TMF_DNA_bd PF12329.3 ESA08231.1 - 0.59 9.9 7.2 0.71 9.7 5.0 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.6 ESA08231.1 - 0.94 9.4 5.8 5.8 6.8 1.6 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Lipase_2 PF01674.13 ESA08232.1 - 0.0012 18.2 1.1 0.0013 18.1 0.7 1.1 1 0 0 1 1 1 1 Lipase (class 2) FadA PF09403.5 ESA08232.1 - 0.013 15.5 4.3 0.016 15.2 3.0 1.2 1 0 0 1 1 1 0 Adhesion protein FadA Pox_A_type_inc PF04508.7 ESA08232.1 - 0.024 14.3 5.2 0.12 12.2 1.1 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat GCOM2 PF15328.1 ESA08232.1 - 0.22 11.2 7.9 0.24 11.0 5.5 1.1 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 COG2 PF06148.6 ESA08232.1 - 0.27 11.1 3.2 0.22 11.3 1.0 1.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Kinesin-relat_1 PF12711.2 ESA08232.1 - 0.29 11.5 3.5 0.72 10.2 2.5 1.7 1 1 0 1 1 1 0 Kinesin motor AAA_23 PF13476.1 ESA08232.1 - 2 8.6 11.2 2.3 8.5 7.8 1.1 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 ESA08232.1 - 2.2 8.1 10.0 3.9 7.3 0.7 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding RIP PF00161.14 ESA08233.1 - 0.013 14.7 0.1 0.072 12.2 0.0 1.9 2 0 0 2 2 2 0 Ribosome inactivating protein DUF4319 PF14203.1 ESA08233.1 - 0.18 11.3 1.6 0.28 10.7 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4319) HALZ PF02183.13 ESA08234.1 - 0.0084 15.8 1.2 0.015 14.9 0.8 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper Tox-GHH2 PF15635.1 ESA08234.1 - 0.074 13.4 0.7 0.082 13.2 0.5 1.1 1 0 0 1 1 1 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin 2 vMSA PF00695.14 ESA08234.1 - 0.11 11.6 0.1 0.12 11.5 0.1 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus DUF1067 PF06362.6 ESA08234.1 - 0.13 12.8 0.1 0.16 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1067) HTH_3 PF01381.17 ESA08235.1 - 0.019 14.8 0.2 0.021 14.6 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix HTH_31 PF13560.1 ESA08235.1 - 0.069 13.3 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Kelch_3 PF13415.1 ESA08236.1 - 5.4e-37 125.1 7.8 3.2e-11 43.0 0.1 6.4 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA08236.1 - 3.6e-35 119.5 7.9 3.5e-12 45.8 0.2 5.3 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA08236.1 - 6e-34 115.4 9.5 2.6e-11 43.2 0.5 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.20 ESA08236.1 - 1.4e-31 107.8 11.2 4.6e-13 48.4 2.2 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ESA08236.1 - 1.3e-25 88.1 4.7 1.4e-12 46.8 0.4 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 ESA08236.1 - 5.8e-24 83.2 12.3 1.9e-11 43.6 0.6 5.3 3 2 2 5 5 5 4 Kelch motif RAG2 PF03089.9 ESA08236.1 - 1.3e-07 30.6 0.1 2.8e-06 26.3 0.0 2.8 1 1 2 3 3 3 1 Recombination activating protein 2 HMG_box PF00505.14 ESA08237.1 - 1.5e-12 47.5 0.0 1.8e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08237.1 - 0.14 12.5 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 HMG-box domain Pkinase PF00069.20 ESA08240.1 - 9.5e-36 123.2 1.9 1.1e-35 123.0 1.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08240.1 - 1.9e-31 109.1 0.1 2.4e-31 108.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2004 PF09406.5 ESA08240.1 - 0.0003 20.7 0.1 0.00072 19.5 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2004) APH PF01636.18 ESA08240.1 - 0.00074 19.3 0.0 0.014 15.1 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family ubiquitin PF00240.18 ESA08242.1 - 2.3e-31 106.9 3.7 8.2e-17 60.3 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA08242.1 - 3.1e-17 62.0 2.5 3.6e-10 39.3 0.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA08242.1 - 0.0019 18.4 4.8 0.16 12.2 0.8 3.0 1 1 1 2 2 2 2 Ubiquitin-like domain IBR PF01485.16 ESA08243.1 - 9.1e-14 51.0 48.2 2.8e-08 33.4 2.6 4.1 3 1 1 4 4 4 3 IBR domain DUF480 PF04337.7 ESA08243.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF480 IL33 PF15095.1 ESA08245.1 - 0.004 16.6 5.4 0.0046 16.4 3.7 1.0 1 0 0 1 1 1 1 Interleukin 33 HrpA_pilin PF09589.5 ESA08245.1 - 0.67 10.3 8.2 5.3 7.5 0.3 2.1 2 0 0 2 2 2 0 HrpA pilus formation protein PP_M1 PF03012.9 ESA08245.1 - 0.78 9.0 7.4 0.93 8.7 5.1 1.0 1 0 0 1 1 1 0 Phosphoprotein DUF2547 PF10818.3 ESA08245.1 - 1 10.0 6.8 0.56 10.8 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) Kelch_4 PF13418.1 ESA08246.1 - 3.2e-18 65.2 7.4 5.6e-06 26.0 0.0 5.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA08246.1 - 3.3e-15 55.5 11.0 0.0038 17.3 0.0 5.3 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA08246.1 - 3.8e-11 42.8 0.7 0.37 11.0 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA08246.1 - 6.5e-11 41.9 6.4 7.7e-05 22.5 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 ESA08246.1 - 4.8e-10 38.7 7.6 0.00069 19.2 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA08246.1 - 1e-08 34.5 13.9 0.01 15.3 0.1 5.6 5 0 0 5 5 5 4 Kelch motif DUF565 PF04483.7 ESA08246.1 - 0.0066 16.5 0.4 0.021 14.9 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF565) Protocadherin PF08374.6 ESA08246.1 - 0.026 14.1 0.1 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Protocadherin Adeno_E3_CR2 PF02439.10 ESA08246.1 - 0.042 13.3 2.4 0.086 12.4 1.7 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ETRAMP PF09716.5 ESA08246.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Sigma_reg_N PF13800.1 ESA08246.1 - 0.38 10.7 4.1 0.25 11.3 0.7 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal BTB PF00651.26 ESA08247.1 - 2.7e-14 53.0 0.3 1.1e-13 51.1 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA08247.1 - 0.0004 20.1 0.1 0.0012 18.6 0.1 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch zf-CCHC PF00098.18 ESA08248.1 - 3.5e-05 23.5 4.4 3.5e-05 23.5 3.1 2.8 2 1 0 2 2 2 1 Zinc knuckle Exo_endo_phos PF03372.18 ESA08248.1 - 0.00011 22.2 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC_4 PF14392.1 ESA08248.1 - 0.012 15.3 0.9 0.012 15.3 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle PAH PF02671.16 ESA08248.1 - 0.2 11.2 5.3 3.5 7.3 0.4 3.7 3 1 0 3 3 3 0 Paired amphipathic helix repeat Hexapep PF00132.19 ESA08250.1 - 4.6e-09 35.3 1.9 1.6e-08 33.6 0.1 2.4 1 1 1 2 2 2 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESA08250.1 - 0.0038 16.7 1.6 0.017 14.6 0.0 2.3 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase NeuB PF03102.9 ESA08251.1 - 1.3e-27 96.5 0.0 1.6e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.7 ESA08251.1 - 4.2e-10 39.8 0.0 6.2e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 SAF domain APH PF01636.18 ESA08252.1 - 1e-05 25.3 0.0 1.2e-05 25.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1264 PF06884.6 ESA08252.1 - 0.079 12.4 0.0 0.084 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1264) DUF1679 PF07914.6 ESA08252.1 - 0.08 11.5 0.3 0.1 11.2 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) ubiquitin PF00240.18 ESA08253.1 - 9.6e-12 44.1 0.0 1.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA08253.1 - 9.9e-10 37.9 0.0 1.8e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ESA08253.1 - 0.015 15.5 0.2 0.038 14.1 0.0 1.8 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA08253.1 - 0.055 13.3 0.3 0.22 11.4 0.0 2.2 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ESA08253.1 - 0.11 11.8 0.4 0.2 11.0 0.3 1.4 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain RRM_2 PF04059.7 ESA08253.1 - 0.21 11.6 1.0 0.77 9.7 0.0 2.3 3 0 0 3 3 3 0 RNA recognition motif 2 BTB PF00651.26 ESA08254.1 - 7.2e-20 71.0 1.2 6.7e-19 67.9 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA08254.1 - 2.5e-08 34.0 0.3 4e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 SPRY domain RXT2_N PF08595.6 ESA08254.1 - 0.00041 20.1 6.3 0.0008 19.2 4.4 1.4 1 0 0 1 1 1 1 RXT2-like, N-terminal CENP-B_dimeris PF09026.5 ESA08254.1 - 0.0032 17.6 11.2 0.0062 16.7 7.8 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FAM176 PF14851.1 ESA08254.1 - 0.019 14.6 3.7 0.033 13.8 2.6 1.3 1 0 0 1 1 1 0 FAM176 family Sigma70_ner PF04546.8 ESA08254.1 - 0.24 11.0 12.7 0.41 10.2 8.8 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.7 ESA08254.1 - 0.88 8.7 11.4 1.4 8.1 7.9 1.2 1 0 0 1 1 1 0 NOA36 protein Upf2 PF04050.9 ESA08254.1 - 1.1 8.9 9.1 2.2 8.0 6.3 1.4 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Cwf_Cwc_15 PF04889.7 ESA08254.1 - 1.4 8.5 13.4 2.3 7.8 9.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 ESA08254.1 - 1.9 6.4 9.8 2.9 5.8 6.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 ESA08254.1 - 1.9 6.2 11.5 2.6 5.8 8.0 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 ESA08254.1 - 3.2 7.2 17.6 5.9 6.3 12.2 1.4 1 0 0 1 1 1 0 Nucleoplasmin DUF4484 PF14831.1 ESA08254.1 - 3.4 7.7 13.1 6.1 6.9 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF2457 PF10446.4 ESA08254.1 - 4.5 5.8 27.3 6.6 5.3 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) C2 PF00168.25 ESA08255.1 - 2.1e-11 43.5 0.4 1.3e-10 40.9 0.0 2.4 2 0 0 2 2 2 1 C2 domain Nic96 PF04097.9 ESA08257.1 - 0.0037 15.4 0.1 0.0041 15.3 0.1 1.0 1 0 0 1 1 1 1 Nup93/Nic96 Sulfate_transp PF00916.15 ESA08258.1 - 9e-08 31.4 12.1 3.4e-07 29.5 8.3 2.0 1 1 0 1 1 1 1 Sulfate transporter family DUF4491 PF14898.1 ESA08258.1 - 0.41 10.8 0.1 0.41 10.8 0.0 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4491) DUF373 PF04123.8 ESA08258.1 - 2.8 6.8 8.2 0.2 10.6 0.7 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF373) DUF4040 PF13244.1 ESA08258.1 - 4 7.4 8.4 4 7.4 1.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4040) GIDA_assoc_3 PF13932.1 ESA08259.1 - 0.025 14.6 4.6 0.025 14.6 3.2 1.8 2 0 0 2 2 2 0 GidA associated domain 3 DUF4449 PF14613.1 ESA08259.1 - 1 9.2 6.0 1.5 8.7 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) KH_1 PF00013.24 ESA08260.1 - 1.7e-52 174.8 15.3 8.1e-18 63.8 0.4 3.6 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 ESA08260.1 - 6.3e-38 127.8 13.6 5.4e-13 48.2 0.7 4.1 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 ESA08260.1 - 2.6e-14 52.5 10.0 0.0008 18.9 0.5 3.8 2 1 0 3 3 3 3 KH domain KH_4 PF13083.1 ESA08260.1 - 8.4e-10 38.1 18.3 2.3e-05 23.9 0.1 4.7 6 0 0 6 6 6 3 KH domain KH_5 PF13184.1 ESA08260.1 - 0.00039 20.1 4.6 0.66 9.8 0.1 3.9 3 0 0 3 3 3 2 NusA-like KH domain Flu_B_M2 PF04772.7 ESA08261.1 - 0.085 12.9 0.0 0.089 12.8 0.0 1.1 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) Hist_deacetyl PF00850.14 ESA08262.1 - 2.9e-11 43.2 0.0 4e-11 42.7 0.0 1.2 1 1 0 1 1 1 1 Histone deacetylase domain DUF1049 PF06305.6 ESA08263.1 - 0.022 14.2 1.5 0.052 13.0 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) Flu_M2 PF00599.12 ESA08263.1 - 0.19 11.5 0.8 0.42 10.4 0.5 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M2) TcdB_N PF12918.2 ESA08264.1 - 0.046 13.8 0.4 0.087 12.9 0.3 1.5 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Pkinase PF00069.20 ESA08266.1 - 2.2e-16 59.7 1.4 6.8e-16 58.1 1.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08266.1 - 1.6e-15 56.9 0.0 2.9e-15 56.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA08266.1 - 0.0098 15.1 0.1 0.016 14.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA08266.1 - 0.046 13.4 0.0 0.13 12.0 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA08266.1 - 0.11 11.8 0.4 0.18 11.1 0.3 1.3 1 0 0 1 1 1 0 RIO1 family Sel1 PF08238.7 ESA08268.1 - 1.1e-46 156.2 9.9 1e-11 45.0 0.7 5.1 5 0 0 5 5 5 5 Sel1 repeat EF-hand_10 PF14788.1 ESA08268.1 - 0.53 9.9 4.0 41 3.9 0.0 4.1 5 0 0 5 5 5 0 EF hand TPR_6 PF13174.1 ESA08268.1 - 0.7 10.4 10.7 3.2 8.4 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA08268.1 - 4.2 7.3 17.9 1.8 8.4 1.7 4.1 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ESA08268.1 - 8.3 7.4 8.4 1.4e+02 3.8 0.1 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat NdhM PF10664.4 ESA08270.1 - 0.072 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M Cupredoxin_1 PF13473.1 ESA08270.1 - 0.31 10.9 2.0 2.8 7.9 0.1 2.3 1 1 1 2 2 2 0 Cupredoxin-like domain DDE_1 PF03184.14 ESA08271.1 - 5.4e-07 28.9 0.0 6.1e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Drf_GBD PF06371.8 ESA08275.1 - 1.5e-33 115.7 0.2 1.5e-33 115.7 0.1 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 ESA08275.1 - 2.8e-25 88.8 4.4 2.8e-25 88.8 3.1 1.8 2 0 0 2 2 2 1 Diaphanous FH3 Domain RICTOR_N PF14664.1 ESA08275.1 - 0.02 13.4 0.1 0.044 12.3 0.0 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Sel1 PF08238.7 ESA08276.1 - 9.7e-28 95.9 3.2 3.2e-11 43.5 0.5 3.1 3 0 0 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA08276.1 - 0.097 12.5 2.2 1.4 8.8 0.8 2.3 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESA08276.1 - 1.1 8.9 3.4 39 4.0 0.1 3.3 2 1 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA08278.1 - 2.5e-54 180.4 16.7 6.7e-13 48.8 0.1 6.1 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA08278.1 - 2.7e-06 27.4 5.4 6.3 7.4 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat MIT PF04212.13 ESA08278.1 - 3e-06 27.0 9.8 0.22 11.4 0.0 4.2 3 2 2 5 5 5 3 MIT (microtubule interacting and transport) domain Acetyltransf_1 PF00583.19 ESA08278.1 - 0.067 13.2 0.3 6.9 6.7 0.0 3.1 2 1 1 3 3 3 0 Acetyltransferase (GNAT) family TPR_11 PF13414.1 ESA08278.1 - 0.11 12.1 17.5 1.2 8.7 0.8 4.5 1 1 3 4 4 4 0 TPR repeat TPR_12 PF13424.1 ESA08278.1 - 0.32 10.9 11.8 4.2 7.3 0.1 5.0 2 1 3 5 5 5 0 Tetratricopeptide repeat NSF PF02071.15 ESA08278.1 - 1.7 9.5 12.4 1.1e+02 4.1 0.1 5.7 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat ELO PF01151.13 ESA08279.1 - 1.7e-66 224.1 16.9 2e-66 223.8 11.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Arrestin_N PF00339.24 ESA08280.1 - 5.2e-11 42.5 0.2 1.2e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 ESA08280.1 - 0.021 14.3 0.1 0.041 13.3 0.1 1.5 1 0 0 1 1 1 0 Arrestin_N terminal like tRNA-synt_1e PF01406.14 ESA08281.1 - 0.028 13.5 0.2 0.037 13.1 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain RBD-FIP PF09457.5 ESA08282.1 - 0.026 14.3 12.2 2.3 8.0 0.1 3.5 3 0 0 3 3 3 0 FIP domain HTH_3 PF01381.17 ESA08282.1 - 0.058 13.2 0.0 0.23 11.3 0.0 2.0 1 1 1 2 2 2 0 Helix-turn-helix DUF2018 PF09442.5 ESA08282.1 - 0.11 13.0 3.3 0.33 11.5 2.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2018) DUF3571 PF12095.3 ESA08282.1 - 3.3 8.0 5.8 9 6.6 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3571) FlxA PF14282.1 ESA08282.1 - 6.5 6.7 6.8 2.8 7.9 1.8 2.3 2 0 0 2 2 2 0 FlxA-like protein DUF755 PF05501.6 ESA08284.1 - 0.13 12.3 0.5 0.16 12.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Tyr-DNA_phospho PF06087.7 ESA08286.1 - 1.9e-54 185.0 0.0 2.1e-54 184.8 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 ESA08286.1 - 1e-06 28.4 0.0 0.017 14.8 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain Pkinase_Tyr PF07714.12 ESA08287.1 - 1.1e-28 100.0 0.0 1.2e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08287.1 - 7.9e-28 97.3 0.0 1e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA08287.1 - 1.2e-05 24.4 0.0 1.4e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA08287.1 - 0.00061 19.5 0.6 0.0012 18.5 0.4 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA08287.1 - 0.0026 17.1 0.0 0.0029 16.9 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA08287.1 - 0.0042 16.1 0.1 0.0046 16.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA08287.1 - 0.038 13.2 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Abhydrolase_3 PF07859.8 ESA08288.1 - 0.00097 18.7 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.20 ESA08289.1 - 1.4e-18 67.0 3.6 4.9e-16 58.6 0.4 2.9 1 1 2 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08289.1 - 5e-15 55.2 0.9 6.4e-12 45.0 0.0 3.0 1 1 2 3 3 3 2 Protein tyrosine kinase RIO1 PF01163.17 ESA08289.1 - 0.0029 16.9 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA08289.1 - 0.012 14.6 0.1 0.023 13.7 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA08289.1 - 0.025 14.3 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3287 PF11690.3 ESA08290.1 - 0.057 13.4 0.7 0.057 13.4 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) FYRC PF05965.9 ESA08292.1 - 0.049 13.4 0.0 0.68 9.7 0.0 2.5 1 1 0 1 1 1 0 F/Y rich C-terminus Phage_Gp19 PF09355.5 ESA08293.1 - 0.022 14.6 1.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 Sec15 PF04091.7 ESA08293.1 - 0.034 13.4 0.6 0.044 13.0 0.4 1.2 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like PUF PF00806.14 ESA08293.1 - 0.083 12.4 0.2 3.1 7.4 0.0 2.8 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat Sec7 PF01369.15 ESA08294.1 - 1.4e-64 217.3 1.5 2.4e-64 216.5 1.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 ESA08294.1 - 3.7e-17 62.2 0.7 9.4e-10 38.1 0.4 2.8 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Cullin_binding PF03556.10 ESA08294.1 - 0.13 12.3 0.2 11 6.1 0.0 3.3 3 0 0 3 3 3 0 Cullin binding Pkinase PF00069.20 ESA08295.1 - 5.2e-08 32.3 0.0 6.6e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08295.1 - 7.5e-07 28.4 0.0 9.6e-07 28.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1975 PF09318.5 ESA08295.1 - 0.023 14.3 4.9 0.025 14.1 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1975) B5 PF03484.10 ESA08295.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetase B5 domain Pox_A22 PF04848.8 ESA08296.1 - 0.0099 15.7 0.2 0.011 15.5 0.2 1.1 1 0 0 1 1 1 1 Poxvirus A22 protein Na_Ca_ex PF01699.19 ESA08298.1 - 8.9e-12 44.7 5.7 8.9e-12 44.7 3.9 1.4 2 0 0 2 2 2 1 Sodium/calcium exchanger protein AgrB PF04647.10 ESA08298.1 - 7.7 5.5 10.4 0.4 9.7 0.2 2.6 3 0 0 3 3 3 0 Accessory gene regulator B SERTA PF06031.8 ESA08299.1 - 0.008 15.4 0.4 0.02 14.1 0.2 1.7 1 0 0 1 1 1 1 SERTA motif Nop14 PF04147.7 ESA08299.1 - 0.85 7.4 11.4 0.98 7.2 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family SCAMP PF04144.8 ESA08300.1 - 2.2e-16 60.2 1.9 2.4e-16 60.1 1.3 1.0 1 0 0 1 1 1 1 SCAMP family RseC_MucC PF04246.7 ESA08300.1 - 0.44 10.1 3.2 0.48 9.9 2.2 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Rio2_N PF09202.6 ESA08304.1 - 0.021 14.8 0.0 14 5.8 0.0 3.6 4 0 0 4 4 4 0 Rio2, N-terminal DUF4047 PF13256.1 ESA08304.1 - 0.055 13.4 9.1 2.5 8.0 0.2 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4047) DUF1677 PF07911.8 ESA08304.1 - 0.23 11.6 7.7 5.9 7.1 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1677) UQ_con PF00179.21 ESA08306.1 - 5.1e-45 152.3 0.0 5.8e-45 152.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA08306.1 - 0.0086 15.9 0.1 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA08306.1 - 0.11 12.1 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain HMG_box PF00505.14 ESA08307.1 - 5.2e-05 23.4 0.7 5.7e-05 23.2 0.5 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08307.1 - 0.0041 17.4 0.7 0.0045 17.3 0.5 1.2 1 0 0 1 1 1 1 HMG-box domain DUF3258 PF11646.3 ESA08307.1 - 0.096 12.8 0.1 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF3258 Mucin PF01456.12 ESA08308.1 - 0.00011 21.9 52.9 0.0014 18.3 22.4 2.3 2 0 0 2 2 2 2 Mucin-like glycoprotein Omega-toxin PF06357.6 ESA08308.1 - 0.0045 16.5 7.2 0.0045 16.5 5.0 2.5 2 0 0 2 2 2 1 Omega-atracotoxin Conotoxin PF02950.12 ESA08308.1 - 0.039 14.7 1.1 0.039 14.7 0.8 3.3 2 1 0 3 3 3 0 Conotoxin SoxE PF06525.6 ESA08308.1 - 2.3 7.4 19.3 0.61 9.3 3.9 2.4 2 0 0 2 2 2 0 Sulfocyanin (SoxE) DUF515 PF04415.7 ESA08308.1 - 6 4.9 12.0 0.36 9.0 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF515) TraG-D_C PF12696.2 ESA08308.1 - 8.2 6.3 8.7 16 5.3 1.7 2.2 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG DUF713 PF05218.9 ESA08310.1 - 0.034 13.8 2.7 0.041 13.6 1.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF713) Glyco_hydro_57 PF03065.10 ESA08310.1 - 0.13 11.1 1.0 6.9 5.4 0.0 2.3 1 1 0 2 2 2 0 Glycosyl hydrolase family 57 zf-C2H2 PF00096.21 ESA08312.1 - 0.0014 18.8 1.7 0.0033 17.6 1.2 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESA08312.1 - 0.0075 16.1 1.9 0.013 15.3 0.6 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESA08312.1 - 0.038 14.3 2.4 0.089 13.1 1.7 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA08312.1 - 0.16 12.2 2.3 6.4 7.2 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger double domain DUF4268 PF14088.1 ESA08313.1 - 0.046 13.3 4.3 0.13 11.8 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4268) Pkinase_Tyr PF07714.12 ESA08314.1 - 1.5e-30 106.1 0.1 1.6e-30 106.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08314.1 - 4.8e-25 88.1 0.0 5.2e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain TRA-1_regulated PF02343.11 ESA08314.1 - 0.011 15.2 0.4 0.019 14.4 0.1 1.5 2 0 0 2 2 2 0 TRA-1 regulated protein R03H10.4 Kdo PF06293.9 ESA08314.1 - 0.08 11.9 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PurS PF02700.9 ESA08315.1 - 0.03 14.2 0.7 0.055 13.4 0.5 1.4 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase zf-BED PF02892.10 ESA08315.1 - 0.14 11.9 0.9 0.14 11.9 0.6 1.8 2 0 0 2 2 2 0 BED zinc finger DUF4163 PF13739.1 ESA08315.1 - 0.63 10.8 6.0 0.85 10.4 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4163) Hat1_N PF10394.4 ESA08316.1 - 0.31 11.0 7.4 0.06 13.4 2.1 2.0 2 0 0 2 2 2 0 Histone acetyl transferase HAT1 N-terminus IFT46_B_C PF12317.3 ESA08316.1 - 0.39 10.0 9.0 0.018 14.3 1.4 2.2 1 1 2 3 3 3 0 Intraflagellar transport complex B protein 46 C terminal YlqD PF11068.3 ESA08316.1 - 0.95 9.5 17.1 1.1 9.2 2.9 2.6 1 1 1 2 2 2 0 YlqD protein DUF4584 PF15223.1 ESA08316.1 - 4.2 6.5 7.9 4.1 6.5 4.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4584) HMG_box PF00505.14 ESA08317.1 - 7.8e-08 32.4 1.3 2.1e-07 31.1 0.7 2.0 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08317.1 - 6.5e-05 23.2 1.8 0.00014 22.1 1.3 1.6 1 0 0 1 1 1 1 HMG-box domain DUF1351 PF07083.6 ESA08317.1 - 0.0012 18.5 0.5 0.068 12.7 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1351) DUF4247 PF14042.1 ESA08317.1 - 0.013 15.4 0.6 0.09 12.7 0.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4247) DUF1657 PF07870.6 ESA08317.1 - 0.033 13.8 0.0 0.098 12.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1657) MRP-L46 PF11788.3 ESA08317.1 - 0.1 13.2 3.4 1 10.0 0.3 2.2 2 0 0 2 2 2 0 39S mitochondrial ribosomal protein L46 LOH1CR12 PF10158.4 ESA08317.1 - 0.4 10.4 3.6 0.14 11.9 0.2 1.8 2 0 0 2 2 2 0 Tumour suppressor protein DUF4492 PF14899.1 ESA08318.1 - 0.021 14.2 1.8 0.16 11.4 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) Imm44 PF15584.1 ESA08318.1 - 0.039 13.7 0.3 0.41 10.5 0.1 2.3 2 0 0 2 2 2 0 Immunity protein 44 gp32 PF08804.5 ESA08318.1 - 5.2 7.2 10.2 0.4 10.8 1.9 2.7 3 0 0 3 3 3 0 gp32 DNA binding protein like Sel1 PF08238.7 ESA08319.1 - 1.1e-87 286.4 41.9 3.1e-09 37.1 0.3 11.0 10 1 1 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ESA08319.1 - 7.9e-05 22.8 16.9 8.6 7.0 0.0 9.3 9 2 1 10 10 10 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA08319.1 - 0.0013 18.7 0.0 0.66 10.0 0.0 3.1 3 0 0 3 3 3 2 Influenza Matrix protein (M1) C-terminal domain CZB PF13682.1 ESA08319.1 - 0.13 12.4 5.4 4.9 7.3 0.2 3.0 2 1 0 2 2 2 0 Chemoreceptor zinc-binding domain zf-C2H2_4 PF13894.1 ESA08320.1 - 0.029 14.7 9.8 0.029 14.7 6.8 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger Brr6_like_C_C PF10104.4 ESA08320.1 - 0.04 13.4 1.4 0.056 12.9 0.9 1.2 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain zf-C2H2 PF00096.21 ESA08320.1 - 0.081 13.3 11.0 0.18 12.1 5.6 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA08320.1 - 3.2 8.2 11.8 1.7 9.1 3.0 3.0 3 0 0 3 3 3 0 Zinc-finger double domain U3_snoRNA_assoc PF08297.6 ESA08324.1 - 0.015 15.5 0.3 0.017 15.3 0.2 1.1 1 0 0 1 1 1 0 U3 snoRNA associated Cu-oxidase PF00394.17 ESA08327.1 - 1.1e-43 148.9 0.1 2.7e-42 144.3 0.0 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.10 ESA08327.1 - 3.6e-41 139.6 2.3 3.6e-41 139.6 1.6 4.1 5 0 0 5 5 5 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA08327.1 - 1.3e-36 125.1 7.8 8.5e-33 112.7 0.3 3.1 2 1 0 2 2 2 2 Multicopper oxidase MgtE_N PF03448.12 ESA08328.1 - 0.026 14.8 0.2 0.037 14.3 0.2 1.2 1 0 0 1 1 1 0 MgtE intracellular N domain VASP_tetra PF08776.6 ESA08328.1 - 0.047 13.0 1.7 0.95 8.8 1.0 2.3 2 0 0 2 2 2 0 VASP tetramerisation domain LMWPc PF01451.16 ESA08328.1 - 0.097 12.9 0.2 0.13 12.5 0.1 1.2 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase DUF3819 PF12842.2 ESA08328.1 - 0.12 12.0 1.8 0.18 11.5 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) DUF2617 PF10936.3 ESA08329.1 - 0.038 13.5 0.0 0.039 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF2617 HATPase_c_3 PF13589.1 ESA08330.1 - 9.3e-12 44.7 0.1 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA08330.1 - 5.4e-10 38.9 0.1 6.2e-10 38.7 0.1 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PCNA_N PF00705.13 ESA08330.1 - 0.028 13.9 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain DUF438 PF04282.8 ESA08330.1 - 0.13 12.0 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF438) TT_ORF1 PF02956.9 ESA08331.1 - 2.5 6.4 7.8 2.8 6.3 5.4 1.1 1 0 0 1 1 1 0 TT viral orf 1 BCS1_N PF08740.6 ESA08332.1 - 8.4e-06 25.5 0.0 0.45 10.1 0.0 3.9 4 0 0 4 4 4 2 BCS1 N terminal Pkinase_Tyr PF07714.12 ESA08332.1 - 0.00016 20.8 0.0 1.7 7.6 0.0 3.5 4 0 0 4 4 4 2 Protein tyrosine kinase PA14_2 PF10528.4 ESA08332.1 - 0.00061 19.7 4.5 1.1 9.2 0.1 3.5 3 0 0 3 3 3 2 GLEYA domain T2SG PF08334.6 ESA08332.1 - 0.0016 18.2 2.1 2.4 7.9 0.1 3.4 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein G DUF3627 PF12299.3 ESA08332.1 - 0.032 14.2 1.8 1.6 8.8 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3627) TraI PF07057.6 ESA08332.1 - 0.049 13.6 0.0 18 5.3 0.0 3.1 3 0 0 3 3 3 0 DNA helicase TraI Sigma70_r1_1 PF03979.9 ESA08332.1 - 5 7.1 5.9 1.5e+02 2.3 0.0 4.1 5 0 0 5 5 5 0 Sigma-70 factor, region 1.1 dsDNA_bind PF01984.15 ESA08333.1 - 3e-25 88.2 6.0 3.2e-25 88.1 4.2 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain TPR_20 PF14561.1 ESA08333.1 - 0.016 15.3 0.4 0.018 15.1 0.3 1.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4610 PF15384.1 ESA08333.1 - 0.16 11.5 0.3 0.16 11.4 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4610) Unstab_antitox PF09720.5 ESA08333.1 - 0.21 11.3 2.1 0.47 10.1 0.0 2.1 1 1 1 2 2 2 0 Putative addiction module component G-patch PF01585.18 ESA08334.1 - 1.7e-14 53.2 5.8 3e-14 52.4 4.0 1.4 1 0 0 1 1 1 1 G-patch domain FHA PF00498.21 ESA08334.1 - 6.7e-13 48.5 0.1 1.7e-12 47.2 0.1 1.8 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.2 ESA08334.1 - 7.8e-08 32.0 1.3 7.8e-08 32.0 0.9 2.0 2 0 0 2 2 2 1 DExH-box splicing factor binding site Saw1 PF11561.3 ESA08334.1 - 0.0033 16.8 1.5 0.0067 15.8 1.1 1.4 1 0 0 1 1 1 1 Single strand annealing-weakened 1 zf-RING_2 PF13639.1 ESA08335.1 - 3e-12 46.1 3.6 3e-12 46.1 2.5 2.2 2 0 0 2 2 2 1 Ring finger domain WWE PF02825.15 ESA08335.1 - 2.4e-08 33.2 0.7 6.2e-08 31.9 0.5 1.7 1 1 0 1 1 1 1 WWE domain zf-rbx1 PF12678.2 ESA08335.1 - 1.4e-07 31.4 1.5 1.4e-07 31.4 1.0 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA08335.1 - 1.4e-06 28.2 2.0 1.4e-06 28.2 1.4 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA08335.1 - 4.3e-06 26.2 2.7 4.3e-06 26.2 1.9 2.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA08335.1 - 1.3e-05 24.7 3.8 1.3e-05 24.7 2.6 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA08335.1 - 0.00017 21.2 3.6 0.00017 21.2 2.5 2.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA08335.1 - 0.0011 18.7 1.0 0.0011 18.7 0.7 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.9 ESA08335.1 - 0.0026 17.2 0.5 0.0026 17.2 0.3 2.4 3 0 0 3 3 3 1 P-11 zinc finger RINGv PF12906.2 ESA08335.1 - 0.011 15.7 1.7 0.011 15.7 1.2 2.3 3 0 0 3 3 3 0 RING-variant domain zf-RanBP PF00641.13 ESA08335.1 - 0.024 13.7 2.8 0.024 13.7 1.9 2.5 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others FANCL_C PF11793.3 ESA08335.1 - 0.39 10.7 7.3 1.1e+02 2.8 3.8 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain Dimer_Tnp_hAT PF05699.9 ESA08336.1 - 1.7e-20 72.4 0.0 1.9e-20 72.2 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RGS PF00615.14 ESA08337.1 - 3.9e-24 85.0 1.8 3.9e-24 85.0 1.2 3.1 3 1 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.16 ESA08337.1 - 7.9e-10 38.3 0.0 2.1e-05 24.1 0.0 3.4 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) LRR_6 PF13516.1 ESA08338.1 - 0.029 14.4 5.6 1.8 8.8 0.0 4.5 4 2 0 4 4 4 0 Leucine Rich repeat HCaRG PF07258.9 ESA08338.1 - 0.052 13.0 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 HCaRG protein UQ_con PF00179.21 ESA08339.1 - 2.9e-39 133.6 0.0 3.6e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA08339.1 - 0.00065 19.5 0.0 0.00085 19.2 0.0 1.4 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 ESA08339.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 UEV domain LIN37 PF15306.1 ESA08340.1 - 0.048 13.6 0.2 0.055 13.4 0.1 1.0 1 0 0 1 1 1 0 LIN37 Abhydrolase_6 PF12697.2 ESA08341.1 - 2.3e-19 70.2 0.0 4e-19 69.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA08341.1 - 6.5e-13 48.6 0.0 1.3e-12 47.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA08341.1 - 5.6e-10 39.1 0.1 7.3e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.8 ESA08341.1 - 0.00049 19.5 0.0 0.00093 18.6 0.0 1.6 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 ESA08341.1 - 0.0051 16.2 0.0 21 4.4 0.0 3.1 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase DUF676 PF05057.9 ESA08341.1 - 0.0091 15.2 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF1749 PF08538.5 ESA08341.1 - 0.024 13.5 0.1 0.087 11.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) TFIIE_beta PF02186.10 ESA08343.1 - 0.33 10.9 1.7 0.63 10.0 1.2 1.5 1 1 0 1 1 1 0 TFIIE beta subunit core domain BTB PF00651.26 ESA08344.1 - 5e-17 61.8 0.1 8.5e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA08344.1 - 3e-14 53.1 0.8 3.6e-12 46.4 0.1 2.7 2 0 0 2 2 2 2 TLD BACK PF07707.10 ESA08344.1 - 8.7e-07 28.7 0.1 2.5e-06 27.2 0.1 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch Pectate_lyase22 PF14583.1 ESA08344.1 - 0.018 13.5 0.0 0.032 12.6 0.0 1.4 1 0 0 1 1 1 0 Oligogalacturonate lyase Pkinase_Tyr PF07714.12 ESA08347.1 - 7.9e-19 67.7 0.1 5.4e-17 61.7 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08347.1 - 1.9e-15 56.7 0.0 3.6e-15 55.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain MRP-L46 PF11788.3 ESA08348.1 - 2.4e-22 79.6 1.6 2.4e-22 79.6 1.1 1.6 2 0 0 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.23 ESA08348.1 - 5.5e-13 48.7 0.1 1.8e-12 47.0 0.0 1.8 1 1 1 2 2 2 1 NUDIX domain DUF1348 PF07080.6 ESA08348.1 - 0.074 12.8 0.2 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1348) Orbi_VP5 PF00901.12 ESA08348.1 - 0.22 9.7 1.8 0.31 9.1 1.3 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Abhydrolase_1 PF00561.15 ESA08349.1 - 0.0024 17.4 0.0 0.0029 17.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF952 PF06108.7 ESA08349.1 - 0.041 13.7 0.1 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF952) Asp PF00026.18 ESA08351.1 - 1.6e-72 244.4 2.1 1.9e-72 244.2 1.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 ESA08351.1 - 1.4e-09 38.2 1.6 0.00011 22.6 0.1 2.9 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.1 ESA08351.1 - 1.2e-06 28.5 0.1 3.2e-06 27.1 0.1 1.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 ESA08351.1 - 0.01 15.3 0.3 0.77 9.2 0.2 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal RVP PF00077.15 ESA08351.1 - 0.019 14.9 0.0 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Retroviral aspartyl protease Med20 PF08612.6 ESA08352.1 - 0.1 11.6 3.1 0.13 11.4 2.1 1.1 1 0 0 1 1 1 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex NTPase_1 PF03266.10 ESA08353.1 - 8.6e-35 119.9 1.1 1.6e-34 119.0 0.7 1.4 1 1 0 1 1 1 1 NTPase AAA_14 PF13173.1 ESA08353.1 - 2.6e-06 27.3 0.6 0.018 14.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESA08353.1 - 3.1e-06 27.4 0.4 0.074 13.2 0.0 2.1 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 ESA08353.1 - 4.1e-05 23.4 0.3 6.2e-05 22.8 0.2 1.2 1 0 0 1 1 1 1 Archaeal ATPase MMR_HSR1 PF01926.18 ESA08353.1 - 0.0002 21.2 1.7 0.0032 17.4 1.2 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 ESA08353.1 - 0.00026 21.1 0.4 0.0013 18.8 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA08353.1 - 0.0005 20.3 3.9 0.0054 17.0 2.7 2.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA08353.1 - 0.0011 19.8 0.1 0.0057 17.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESA08353.1 - 0.0011 19.0 0.1 0.0053 16.9 0.0 2.0 2 0 0 2 2 2 1 RNA helicase KTI12 PF08433.5 ESA08353.1 - 0.004 16.4 0.1 0.01 15.0 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 CbiA PF01656.18 ESA08353.1 - 0.0065 15.9 0.3 0.14 11.4 0.2 2.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Miro PF08477.8 ESA08353.1 - 0.0068 16.9 0.2 0.024 15.1 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 ESA08353.1 - 0.036 14.0 0.0 0.094 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.1 ESA08353.1 - 0.036 13.4 0.1 0.34 10.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESA08353.1 - 0.041 13.4 0.1 5.9 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 ESA08353.1 - 0.041 12.8 0.0 0.061 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MobB PF03205.9 ESA08353.1 - 0.075 12.7 0.7 0.21 11.2 0.0 2.1 2 2 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B 6PF2K PF01591.13 ESA08353.1 - 0.1 11.6 3.2 0.12 11.4 0.0 2.3 2 1 1 3 3 3 0 6-phosphofructo-2-kinase DnaJ PF00226.26 ESA08356.1 - 0.0082 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain PrkA PF06798.7 ESA08356.1 - 0.03 13.6 0.2 0.031 13.5 0.1 1.1 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain DUF659 PF04937.10 ESA08357.1 - 1e-06 28.3 0.0 1.6e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) DUF2262 PF10020.4 ESA08357.1 - 0.092 12.9 0.1 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) AdoHcyase PF05221.12 ESA08359.1 - 2.1e-130 433.4 0.1 2.4e-130 433.2 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 ESA08359.1 - 1.8e-84 281.5 4.2 3.4e-84 280.6 2.9 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 ESA08359.1 - 8.1e-11 41.3 0.4 4.1e-10 39.0 0.2 2.0 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESA08359.1 - 9.1e-05 21.8 0.4 0.00015 21.2 0.3 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Shikimate_DH PF01488.15 ESA08359.1 - 0.0019 18.2 0.3 0.0077 16.3 0.3 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.14 ESA08359.1 - 0.012 14.7 2.1 0.064 12.3 1.3 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.13 ESA08359.1 - 0.012 15.6 0.5 0.076 13.0 0.2 2.3 2 0 0 2 2 2 0 TrkA-N domain DUF4448 PF14610.1 ESA08359.1 - 0.11 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) NAD_binding_7 PF13241.1 ESA08359.1 - 0.13 12.4 1.0 0.47 10.7 0.5 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Pkinase PF00069.20 ESA08361.1 - 5.4e-55 186.3 0.3 3e-35 121.6 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08361.1 - 2.7e-25 88.9 0.1 5e-17 61.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESA08361.1 - 7.7e-05 21.7 0.0 0.022 13.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_C PF00433.19 ESA08361.1 - 0.0016 18.9 0.0 0.004 17.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.18 ESA08361.1 - 0.0046 16.7 3.0 0.083 12.6 0.9 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Metallopep PF12044.3 ESA08362.1 - 2.6e-136 454.4 0.0 3.5e-136 454.0 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 ESA08362.1 - 6.1e-10 39.0 3.4 1.4e-09 37.9 2.4 1.6 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_2 PF13574.1 ESA08362.1 - 0.0027 17.8 0.0 0.0052 16.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 ESA08362.1 - 0.026 14.4 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 ESA08362.1 - 0.039 14.4 0.4 0.079 13.4 0.3 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF1771 PF08590.5 ESA08363.1 - 7.1e-19 67.5 6.6 1e-18 67.1 4.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 ESA08363.1 - 2.4e-14 53.2 0.0 4.3e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Smr domain DUF2924 PF11149.3 ESA08363.1 - 0.016 15.1 1.4 0.024 14.6 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) O-FucT PF10250.4 ESA08364.1 - 3.1e-12 46.2 1.6 1e-10 41.2 1.1 2.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Uma2 PF05685.7 ESA08365.1 - 4.8e-05 22.7 0.0 7.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease DapH_N PF08503.5 ESA08365.1 - 0.034 14.2 0.1 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrodipicolinate succinyltransferase N-terminal Sel1 PF08238.7 ESA08366.1 - 8.7e-46 153.3 5.3 3.2e-11 43.4 0.3 5.2 5 0 0 5 5 5 4 Sel1 repeat TPR_11 PF13414.1 ESA08366.1 - 0.00043 19.8 8.9 0.038 13.6 0.1 3.5 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.1 ESA08366.1 - 0.0028 17.9 3.3 36 5.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA08366.1 - 0.015 15.0 0.7 8.8 6.4 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08366.1 - 0.085 12.7 8.2 13 5.7 0.0 4.3 2 2 1 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA08366.1 - 0.091 12.6 11.7 2.2 8.2 0.8 4.0 1 1 3 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 ESA08366.1 - 1 9.4 15.1 15 5.7 0.1 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA08367.1 - 2.5e-30 105.5 0.0 3e-30 105.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08367.1 - 1.2e-28 99.9 0.0 1.4e-28 99.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA08367.1 - 0.00042 19.5 0.0 0.00053 19.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA08367.1 - 0.0028 17.4 0.4 0.0043 16.8 0.3 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA08367.1 - 0.0038 16.3 0.0 0.0046 16.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA08367.1 - 0.0046 16.3 0.0 0.0053 16.1 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA08367.1 - 0.0075 15.2 0.0 0.0085 15.0 0.0 1.0 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA08367.1 - 0.017 14.4 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Sel1 PF08238.7 ESA08368.1 - 1.4e-11 44.6 1.9 0.012 16.2 0.2 3.4 3 0 0 3 3 3 3 Sel1 repeat Sel1 PF08238.7 ESA08369.1 - 1.2e-97 318.1 44.0 5.8e-12 45.8 0.5 9.0 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA08369.1 - 1.8e-10 40.5 21.6 0.22 12.0 0.1 7.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08369.1 - 3.2e-06 26.7 39.4 0.00086 18.9 3.1 5.4 2 1 3 6 6 6 3 TPR repeat TPR_14 PF13428.1 ESA08369.1 - 0.017 15.7 0.3 1.1e+02 3.9 0.0 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08369.1 - 0.06 13.2 23.5 1.5 8.8 1.0 6.1 3 1 2 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA08369.1 - 0.098 13.0 15.9 3 8.2 0.2 5.4 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA08369.1 - 0.12 13.0 5.6 3.1 8.5 0.0 5.1 4 3 3 7 7 7 0 Tetratricopeptide repeat Phage_Nu1 PF07471.7 ESA08369.1 - 0.13 11.7 2.1 0.22 10.9 0.1 2.1 2 0 0 2 2 2 0 Phage DNA packaging protein Nu1 TPR_17 PF13431.1 ESA08369.1 - 0.75 10.1 21.2 12 6.4 0.2 7.3 7 1 1 8 8 8 0 Tetratricopeptide repeat EST1_DNA_bind PF10373.4 ESA08369.1 - 1.2 8.3 4.6 1.6 7.8 0.2 2.4 2 1 0 3 3 3 0 Est1 DNA/RNA binding domain zf-C4pol PF14260.1 ESA08370.1 - 1.1e-24 86.1 6.3 1.7e-24 85.6 4.4 1.3 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B PF00136.16 ESA08370.1 - 2.2e-17 63.0 0.0 2.9e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DUF2757 PF10955.3 ESA08370.1 - 0.024 14.8 2.1 0.086 13.0 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2757) zinc-ribbons_6 PF07191.7 ESA08370.1 - 0.08 12.7 4.6 2.1 8.2 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.2 ESA08370.1 - 0.14 11.9 0.5 0.14 11.9 0.4 2.2 2 0 0 2 2 2 0 Double zinc ribbon NinF PF05810.7 ESA08370.1 - 0.21 11.4 0.2 0.21 11.4 0.2 1.9 2 0 0 2 2 2 0 NinF protein Yippee-Mis18 PF03226.9 ESA08370.1 - 0.25 11.4 5.3 1.4 9.0 0.5 3.0 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Prok-RING_1 PF14446.1 ESA08370.1 - 0.52 10.0 9.3 0.42 10.3 1.8 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.17 ESA08370.1 - 0.99 9.1 10.1 6.5 6.5 7.0 2.1 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPR_11 PF13414.1 ESA08372.1 - 0.027 14.0 0.0 2.8 7.6 0.0 2.8 2 0 0 2 2 2 0 TPR repeat Metallophos PF00149.23 ESA08373.1 - 4.2e-44 150.3 0.3 5.2e-44 150.0 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TLD PF07534.11 ESA08374.1 - 0.033 14.1 0.2 0.11 12.5 0.1 1.7 1 1 0 1 1 1 0 TLD TLD PF07534.11 ESA08376.1 - 1.4e-14 54.2 0.3 2.2e-14 53.6 0.2 1.3 1 0 0 1 1 1 1 TLD DUF3942 PF13078.1 ESA08376.1 - 0.026 14.6 0.4 0.051 13.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) Sel1 PF08238.7 ESA08377.1 - 7.9e-118 382.3 66.4 1.1e-09 38.5 0.2 20.3 20 0 0 20 20 20 19 Sel1 repeat TPR_6 PF13174.1 ESA08377.1 - 1.9e-06 27.9 36.8 1.2 9.7 0.1 12.2 14 0 0 14 14 14 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA08377.1 - 0.022 15.1 11.8 3.6 7.9 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08377.1 - 0.13 11.8 42.8 0.29 10.7 0.5 8.9 8 1 2 10 10 10 0 TPR repeat ABC_tran PF00005.22 ESA08378.1 - 9.7e-05 22.6 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.11 ESA08378.1 - 0.00048 19.3 0.0 0.0015 17.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 T2SE PF00437.15 ESA08378.1 - 0.0048 15.8 0.0 0.0057 15.5 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ESA08378.1 - 0.0098 15.3 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family IstB_IS21 PF01695.12 ESA08378.1 - 0.017 14.5 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.1 ESA08378.1 - 0.044 13.3 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ESA08378.1 - 0.058 12.8 0.1 0.082 12.3 0.1 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 ESA08378.1 - 0.11 13.3 0.1 0.32 11.8 0.0 1.9 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA08378.1 - 0.12 11.8 0.0 0.44 10.0 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LRR_1 PF00560.28 ESA08378.1 - 2.6 8.3 7.0 17 5.9 0.1 4.1 2 1 0 3 3 3 0 Leucine Rich Repeat DUF3863 PF12979.2 ESA08379.1 - 0.058 11.9 0.3 0.073 11.6 0.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3863) HMG_box PF00505.14 ESA08380.1 - 3.1e-07 30.5 0.8 5.9e-07 29.6 0.6 1.5 1 1 0 1 1 1 1 HMG (high mobility group) box EspF PF04806.7 ESA08381.1 - 1.7 8.8 6.0 18 5.6 4.2 2.0 1 1 0 1 1 1 0 EspF protein repeat DUF2578 PF10843.3 ESA08385.1 - 0.028 14.1 0.4 0.04 13.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2578) Ribosomal_L28e PF01778.12 ESA08386.1 - 0.0021 18.4 1.1 4 7.8 0.0 3.6 3 0 0 3 3 3 2 Ribosomal L28e protein family Caleosin PF05042.8 ESA08389.1 - 2.1e-58 196.7 0.0 3.1e-58 196.1 0.0 1.2 1 0 0 1 1 1 1 Caleosin related protein EF-hand_6 PF13405.1 ESA08389.1 - 1.6e-06 27.5 3.0 0.00098 18.8 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 ESA08389.1 - 1.6e-05 23.8 0.3 0.0064 15.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 ESA08389.1 - 3.1e-05 24.0 0.1 0.23 11.6 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 ESA08389.1 - 0.0045 16.5 0.1 0.24 11.0 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 ESA08389.1 - 0.13 11.6 1.7 5.6 6.4 0.1 2.5 2 0 0 2 2 2 0 EF hand Hid1 PF12722.2 ESA08389.1 - 5.9 4.4 14.7 6.7 4.2 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3760 PF12586.3 ESA08391.1 - 0.0033 17.2 0.0 3.6 7.4 0.0 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF3760) Apolipoprotein PF01442.13 ESA08393.1 - 0.0026 17.3 6.4 0.0045 16.5 4.4 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain OmpH PF03938.9 ESA08393.1 - 0.01 15.7 12.8 0.017 15.0 8.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3461 PF11944.3 ESA08393.1 - 0.1 12.4 9.5 0.15 11.8 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Ykof PF07615.6 ESA08393.1 - 0.11 12.6 1.1 0.48 10.6 0.0 2.2 1 1 0 2 2 2 0 YKOF-related Family GBP_C PF02841.9 ESA08393.1 - 0.47 9.5 15.1 0.58 9.2 10.4 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain HSBP1 PF06825.7 ESA08393.1 - 0.89 9.1 24.2 0.13 11.8 3.9 3.3 2 1 1 3 3 3 0 Heat shock factor binding protein 1 Prenyltransf PF01255.14 ESA08393.1 - 1.1 8.3 9.6 0.63 9.1 4.2 2.2 1 1 0 2 2 2 0 Putative undecaprenyl diphosphate synthase Kinetocho_Slk19 PF12709.2 ESA08393.1 - 1.2 9.2 8.4 4.2 7.5 1.9 2.2 1 1 1 2 2 2 0 Central kinetochore-associated UXS1_N PF11803.3 ESA08393.1 - 2.4 8.0 10.6 1.2 8.9 0.6 2.6 1 1 1 2 2 2 0 UDP-glucuronate decarboxylase N-terminal DUF848 PF05852.6 ESA08393.1 - 3.3 7.5 9.5 4.7 7.0 6.6 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF2203 PF09969.4 ESA08393.1 - 4.1 7.6 6.5 8.4 6.6 4.5 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Phage_Mu_Gam PF07352.7 ESA08393.1 - 4.2 6.8 13.9 8.7 5.8 4.2 2.8 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein COG2 PF06148.6 ESA08393.1 - 6.8 6.5 9.2 7.4 6.4 2.3 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cys_Met_Meta_PP PF01053.15 ESA08394.1 - 4.8e-52 176.5 0.0 5.3e-52 176.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 ESA08394.1 - 3.5e-06 26.3 0.1 1.2e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 ESA08394.1 - 2.2e-05 23.6 0.0 3.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pkinase_Tyr PF07714.12 ESA08395.1 - 4.4e-18 65.2 0.9 2.5e-09 36.5 0.1 3.7 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA08395.1 - 3.1e-16 59.2 2.1 3.2e-13 49.4 0.3 2.3 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA08395.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Amidase_2 PF01510.20 ESA08396.1 - 2.1e-15 56.9 0.0 3.2e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Pkinase_Tyr PF07714.12 ESA08399.1 - 2.3e-22 79.3 0.1 4e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08399.1 - 1.5e-17 63.6 0.2 2.9e-17 62.6 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain DHC_N1 PF08385.7 ESA08399.1 - 0.00066 18.1 5.1 0.00085 17.8 3.6 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 RPW8 PF05659.6 ESA08399.1 - 0.072 12.6 5.6 0.02 14.4 1.2 2.1 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF869 PF05911.6 ESA08399.1 - 0.11 10.6 2.4 0.15 10.3 1.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF1664 PF07889.7 ESA08399.1 - 0.24 11.2 5.1 0.54 10.0 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) F-box-like PF12937.2 ESA08400.1 - 0.0045 16.6 0.4 0.015 14.9 0.2 1.9 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.20 ESA08402.1 - 4.2e-30 104.7 0.1 4.8e-30 104.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08402.1 - 2.6e-29 102.1 0.0 2.9e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA08402.1 - 3.4e-06 26.5 0.1 4.1e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA08402.1 - 0.00038 19.5 0.0 0.00041 19.4 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA08402.1 - 0.0024 17.6 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA08402.1 - 0.0054 15.8 0.0 0.0065 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3825 PF12873.2 ESA08402.1 - 0.016 14.3 0.2 0.018 14.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) WaaY PF06176.6 ESA08402.1 - 0.017 14.3 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA08402.1 - 0.03 13.6 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Cornichon PF03311.9 ESA08403.1 - 8.9e-52 174.5 11.1 1e-51 174.4 7.7 1.0 1 0 0 1 1 1 1 Cornichon protein DUF21 PF01595.15 ESA08403.1 - 0.56 9.4 0.0 0.56 9.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function DUF21 Ecl1 PF12855.2 ESA08404.1 - 7.5e-05 21.9 3.3 0.00015 21.0 2.3 1.5 1 0 0 1 1 1 1 Life-span regulatory factor zf-MYND PF01753.13 ESA08404.1 - 0.023 14.5 2.4 0.042 13.7 1.7 1.4 1 0 0 1 1 1 0 MYND finger DUF581 PF04570.9 ESA08404.1 - 1.4 8.2 5.3 5.5 6.3 3.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF581) Pkinase PF00069.20 ESA08405.1 - 5.4e-35 120.7 0.1 1.5e-34 119.3 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08405.1 - 2.1e-34 118.7 0.3 8.9e-33 113.4 0.2 2.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA08405.1 - 0.0084 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA08405.1 - 0.036 13.0 0.0 0.064 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like PSD4 PF07631.6 ESA08405.1 - 2 8.7 5.7 0.44 10.9 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1592) F-box-like PF12937.2 ESA08406.1 - 0.058 13.1 0.2 0.19 11.4 0.2 1.9 1 0 0 1 1 1 0 F-box-like SAGA-Tad1 PF12767.2 ESA08406.1 - 0.086 12.4 0.4 3.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit TFIIE_beta PF02186.10 ESA08407.1 - 0.0022 17.9 0.4 0.0022 17.9 0.3 1.7 2 0 0 2 2 2 1 TFIIE beta subunit core domain DUF1322 PF07032.6 ESA08407.1 - 0.048 13.8 0.1 0.098 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1322) Tir_receptor_C PF07489.6 ESA08407.1 - 0.18 11.5 2.5 0.22 11.2 1.7 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF3949 PF13133.1 ESA08407.1 - 0.44 10.8 4.9 0.42 10.8 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3949) Methyltransf_23 PF13489.1 ESA08409.1 - 1.6e-12 47.4 0.0 2.5e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08409.1 - 1.6e-12 47.7 0.0 3e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08409.1 - 2.7e-08 34.0 0.0 5.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08409.1 - 2.8e-07 30.2 0.0 7.8e-07 28.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08409.1 - 5.2e-07 30.0 0.0 1.4e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA08409.1 - 2.6e-06 26.6 0.0 6.9e-06 25.2 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.13 ESA08409.1 - 5.8e-05 22.3 0.0 9.3e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA08409.1 - 0.00032 21.2 0.0 0.0015 19.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA08409.1 - 0.007 16.3 0.0 0.0092 15.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 ESA08409.1 - 0.0075 15.9 0.0 0.023 14.2 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.11 ESA08409.1 - 0.048 11.9 0.0 0.75 8.0 0.0 2.1 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase gag-asp_proteas PF13975.1 ESA08412.1 - 0.032 14.0 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA08412.1 - 0.13 12.8 0.0 0.26 11.7 0.0 1.5 2 0 0 2 2 2 0 Aspartyl protease DUF948 PF06103.6 ESA08414.1 - 0.00037 20.3 0.3 0.00047 19.9 0.2 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.1 ESA08414.1 - 0.00084 19.2 2.4 0.0014 18.5 1.7 1.3 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.4 ESA08414.1 - 0.0041 16.9 2.1 0.0052 16.6 1.4 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GidB PF02527.10 ESA08414.1 - 0.0053 15.9 1.3 0.0061 15.7 0.9 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Dynamitin PF04912.9 ESA08414.1 - 0.008 15.0 0.5 0.0089 14.8 0.4 1.1 1 0 0 1 1 1 1 Dynamitin Spectrin PF00435.16 ESA08414.1 - 0.02 15.1 1.0 0.029 14.6 0.6 1.4 1 1 0 1 1 1 0 Spectrin repeat NPV_P10 PF05531.7 ESA08414.1 - 0.025 14.8 0.9 0.033 14.4 0.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF489 PF04356.7 ESA08414.1 - 0.027 14.0 0.7 0.033 13.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) PhaP_Bmeg PF09602.5 ESA08414.1 - 0.037 13.8 0.2 0.043 13.6 0.2 1.1 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) HTH_25 PF13413.1 ESA08414.1 - 0.082 12.5 2.1 0.14 11.8 0.6 2.0 1 1 1 2 2 2 0 Helix-turn-helix domain IncA PF04156.9 ESA08414.1 - 0.1 12.1 0.9 0.11 12.0 0.6 1.2 1 0 0 1 1 1 0 IncA protein CALCOCO1 PF07888.6 ESA08414.1 - 0.12 10.6 2.3 0.12 10.6 1.6 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like SlyX PF04102.7 ESA08414.1 - 0.18 12.2 1.2 7.3 7.0 0.6 2.5 1 1 1 2 2 2 0 SlyX NYD-SP28_assoc PF14775.1 ESA08414.1 - 0.27 10.9 2.4 0.58 9.8 1.5 1.8 1 1 0 1 1 1 0 Sperm tail C-terminal domain DUF904 PF06005.7 ESA08414.1 - 0.28 11.5 5.5 0.29 11.4 3.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) WD40_alt PF14077.1 ESA08414.1 - 0.29 10.7 1.7 3.8 7.2 0.5 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif V_ATPase_I PF01496.14 ESA08414.1 - 0.32 8.8 1.5 0.31 8.8 1.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ORF6C PF10552.4 ESA08414.1 - 0.39 10.4 3.5 0.28 10.9 1.2 1.7 1 1 0 1 1 1 0 ORF6C domain bZIP_1 PF00170.16 ESA08414.1 - 0.69 9.9 6.2 0.16 11.9 1.4 2.2 2 1 0 2 2 2 0 bZIP transcription factor DivIC PF04977.10 ESA08414.1 - 2.4 7.6 5.8 6.2 6.3 4.0 1.8 1 1 0 1 1 1 0 Septum formation initiator XhlA PF10779.4 ESA08414.1 - 3.1 7.7 6.9 8.8 6.3 4.8 1.9 1 1 0 1 1 1 0 Haemolysin XhlA bZIP_2 PF07716.10 ESA08414.1 - 9.5 6.1 10.7 1.2 8.9 2.5 2.7 1 1 2 3 3 3 0 Basic region leucine zipper Pkinase_Tyr PF07714.12 ESA08415.1 - 0.011 14.8 0.5 0.049 12.6 0.0 2.1 2 1 1 3 3 3 0 Protein tyrosine kinase CRC_subunit PF08624.5 ESA08416.1 - 0.06 13.2 0.4 0.34 10.8 0.1 2.2 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Sel1 PF08238.7 ESA08418.1 - 1.3e-127 413.4 72.3 1e-12 48.2 0.1 12.0 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA08418.1 - 7.9e-09 35.4 30.2 0.13 12.7 0.3 11.0 11 0 0 11 11 11 1 Tetratricopeptide repeat SinI PF08671.5 ESA08418.1 - 0.0034 16.7 12.3 35 3.9 0.0 8.1 8 0 0 8 8 8 0 Anti-repressor SinI DUF2530 PF10745.4 ESA08418.1 - 0.013 15.4 0.0 30 4.6 0.0 5.3 8 0 0 8 8 8 0 Protein of unknown function (DUF2530) DUF1327 PF07041.6 ESA08418.1 - 0.078 12.8 0.3 4.8 7.1 0.0 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1327) Fer4_7 PF12838.2 ESA08418.1 - 0.23 11.8 0.7 3.2e+02 1.8 0.0 5.5 4 3 0 4 4 4 0 4Fe-4S dicluster domain Spindle_Spc25 PF08234.7 ESA08419.1 - 0.077 12.9 0.2 0.11 12.4 0.1 1.3 1 1 0 1 1 1 0 Chromosome segregation protein Spc25 Toprim_4 PF13662.1 ESA08419.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Toprim domain HMG_box PF00505.14 ESA08419.1 - 0.13 12.5 0.3 0.17 12.1 0.2 1.4 1 1 0 1 1 1 0 HMG (high mobility group) box HHH_3 PF12836.2 ESA08421.1 - 9.9e-05 22.2 0.1 0.0002 21.2 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif GBP_C PF02841.9 ESA08421.1 - 0.011 14.9 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain HHH PF00633.18 ESA08421.1 - 0.021 14.5 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif CSTF_C PF14304.1 ESA08424.1 - 0.038 13.2 0.0 0.068 12.4 0.0 1.4 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal TGT PF01702.13 ESA08425.1 - 6.1e-63 212.2 0.0 7.9e-63 211.9 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Pkinase PF00069.20 ESA08426.1 - 1.2e-24 86.9 0.4 1.7e-24 86.3 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08426.1 - 1.2e-22 80.1 0.1 1.8e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Asp PF00026.18 ESA08427.1 - 0.028 13.6 0.1 0.034 13.4 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic aspartyl protease YTH PF04146.10 ESA08430.1 - 5.3e-49 165.4 0.0 6.8e-49 165.0 0.0 1.1 1 0 0 1 1 1 1 YT521-B-like domain Pkinase_Tyr PF07714.12 ESA08434.1 - 1.6e-12 47.0 0.1 4e-06 26.0 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA08434.1 - 4e-11 42.5 0.0 1.3e-06 27.7 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain DUF3829 PF12889.2 ESA08434.1 - 0.00041 19.6 1.1 0.00041 19.6 0.8 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3829) DUF1664 PF07889.7 ESA08434.1 - 0.015 15.0 3.4 2.6 7.8 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1722 PF08349.6 ESA08434.1 - 0.017 14.9 0.7 0.16 11.8 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1722) MitMem_reg PF13012.1 ESA08434.1 - 0.082 13.0 1.1 1.7 8.7 0.0 2.5 1 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Baculo_PEP_C PF04513.7 ESA08434.1 - 0.21 11.4 2.4 0.23 11.2 0.2 2.2 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF972 PF06156.8 ESA08434.1 - 0.31 11.4 5.2 0.28 11.5 0.2 2.8 2 1 2 4 4 4 0 Protein of unknown function (DUF972) Tropomyosin PF00261.15 ESA08434.1 - 0.49 9.4 5.7 6.8 5.7 0.8 2.4 2 0 0 2 2 2 0 Tropomyosin HeLo PF14479.1 ESA08434.1 - 0.97 9.1 4.5 23 4.6 3.2 2.4 1 1 0 1 1 1 0 Prion-inhibition and propagation DUF4200 PF13863.1 ESA08434.1 - 2.2 8.2 11.8 5.9 6.8 0.2 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) Seryl_tRNA_N PF02403.17 ESA08434.1 - 3.7 7.6 8.3 6.3 6.8 0.2 2.9 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain FBA_2 PF07735.12 ESA08435.1 - 0.0076 16.0 0.2 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 F-box associated DUF4112 PF13430.1 ESA08436.1 - 6.6e-22 77.4 0.4 8.9e-22 77.0 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) F-box-like PF12937.2 ESA08437.1 - 1.4e-05 24.6 0.3 3.4e-05 23.4 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA08437.1 - 0.00014 21.4 0.0 0.00047 19.7 0.0 2.0 1 0 0 1 1 1 1 F-box domain DUF3092 PF11289.3 ESA08437.1 - 0.01 15.0 0.7 0.023 13.9 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3092) DUF374 PF04028.8 ESA08438.1 - 0.055 12.7 0.0 0.31 10.2 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF374) PLA2_B PF01735.13 ESA08439.1 - 4.4e-19 68.0 0.0 7.1e-16 57.4 0.0 3.2 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Reo_sigmaC PF04582.7 ESA08440.1 - 0.052 12.7 0.4 0.052 12.7 0.3 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF1515 PF07439.6 ESA08440.1 - 0.11 12.2 0.1 0.18 11.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) Fib_alpha PF08702.5 ESA08440.1 - 0.19 11.8 3.3 0.27 11.3 2.3 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.14 ESA08440.1 - 0.33 8.7 2.9 0.35 8.6 2.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_DNA_bd PF12329.3 ESA08440.1 - 0.73 9.6 4.2 1.1 9.1 2.6 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding HMG_box PF00505.14 ESA08441.1 - 1.7e-07 31.4 1.9 2.8e-07 30.7 1.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA08441.1 - 0.018 14.3 0.1 0.032 13.5 0.1 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG_box_2 PF09011.5 ESA08441.1 - 0.043 14.1 1.4 0.075 13.4 1.0 1.3 1 0 0 1 1 1 0 HMG-box domain eIF-5_eIF-2B PF01873.12 ESA08442.1 - 0.0062 16.1 0.3 0.0076 15.9 0.2 1.3 1 1 0 1 1 1 1 Domain found in IF2B/IF5 Pkinase PF00069.20 ESA08445.1 - 2e-21 76.3 0.4 1e-11 44.5 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08445.1 - 6.4e-21 74.5 0.1 2.6e-11 43.0 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase E1_DerP2_DerF2 PF02221.10 ESA08446.1 - 1.9e-06 28.1 0.2 2.2e-06 27.9 0.2 1.1 1 0 0 1 1 1 1 ML domain MitMem_reg PF13012.1 ESA08447.1 - 3.7 7.6 7.0 1.1 9.3 2.3 1.9 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Helitron_like_N PF14214.1 ESA08448.1 - 0.086 12.5 0.3 0.16 11.6 0.1 1.5 1 1 0 1 1 1 0 Helitron helicase-like domain at N-terminus SET PF00856.23 ESA08452.1 - 1.5e-15 57.8 0.7 4.9e-15 56.2 0.5 1.9 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.13 ESA08452.1 - 2.2e-09 37.0 15.0 2.2e-09 37.0 10.4 3.0 4 0 0 4 4 4 1 MYND finger TPR_12 PF13424.1 ESA08452.1 - 6e-05 22.9 0.1 0.0022 17.8 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA08452.1 - 0.055 13.4 0.1 30 4.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA08452.1 - 0.16 11.8 0.3 43 4.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-Mss51 PF13824.1 ESA08452.1 - 2.8 7.8 12.6 0.24 11.2 3.9 2.7 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Fer4_18 PF13746.1 ESA08454.1 - 0.089 13.2 0.3 0.26 11.7 0.1 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain NOB1_Zn_bind PF08772.6 ESA08456.1 - 7.1e-05 22.5 5.2 0.098 12.4 0.2 2.3 2 0 0 2 2 2 2 Nin one binding (NOB1) Zn-ribbon like Cas_Csa5 PF09702.5 ESA08456.1 - 0.039 14.0 0.9 3.9 7.6 0.0 3.0 4 0 0 4 4 4 0 CRISPR-associated protein (Cas_Csa5) SHS2_FTSA PF02491.15 ESA08456.1 - 0.11 12.4 0.6 34 4.3 0.0 3.3 3 2 1 4 4 4 0 SHS2 domain inserted in FTSA DZR PF12773.2 ESA08456.1 - 0.12 12.1 6.7 1.5 8.7 0.4 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-FPG_IleRS PF06827.9 ESA08456.1 - 0.81 9.3 11.2 0.12 12.0 1.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-C4pol PF14260.1 ESA08456.1 - 0.91 9.5 7.0 3.8 7.5 0.4 2.8 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DnaJ_CXXCXGXG PF00684.14 ESA08456.1 - 1.9 8.5 7.8 3 7.9 0.6 2.3 2 0 0 2 2 2 0 DnaJ central domain Sel1 PF08238.7 ESA08458.1 - 2.4e-54 180.5 5.5 1e-12 48.2 0.2 5.3 5 0 0 5 5 5 5 Sel1 repeat Smr PF01713.16 ESA08458.1 - 5e-10 39.4 0.3 4.4e-08 33.1 0.0 2.8 2 0 0 2 2 2 1 Smr domain TPR_16 PF13432.1 ESA08458.1 - 0.00072 20.1 1.2 0.12 13.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Prenyltrans_1 PF13243.1 ESA08458.1 - 0.0016 18.4 1.4 4.7 7.2 0.0 3.5 2 1 1 3 3 3 2 Prenyltransferase-like TPR_2 PF07719.12 ESA08458.1 - 0.0027 17.4 3.5 6.1 7.0 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA08458.1 - 0.029 14.8 1.5 1.2 9.8 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA08458.1 - 0.088 12.4 1.4 16 5.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat GCV_T PF01571.16 ESA08459.1 - 5.3e-09 35.7 0.0 9.2e-09 34.9 0.0 1.4 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 ESA08459.1 - 3.5e-05 23.7 0.0 6.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Imm24 PF15570.1 ESA08460.1 - 0.03 14.0 8.4 0.035 13.8 4.8 1.7 1 1 1 2 2 2 0 Immunity protein 24 DUF3364 PF11844.3 ESA08460.1 - 0.33 11.0 3.0 7.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3364) Glyco_transf_41 PF13844.1 ESA08462.1 - 0.1 10.5 0.0 0.14 10.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 SAM_1 PF00536.25 ESA08462.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) NOB1_Zn_bind PF08772.6 ESA08465.1 - 0.023 14.4 12.7 0.4 10.5 2.1 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF1945 PF09178.5 ESA08465.1 - 0.19 11.6 2.8 1.7 8.5 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1945) Rota_NSP3 PF01665.11 ESA08465.1 - 1.2 8.0 20.4 0.71 8.7 4.4 2.1 2 0 0 2 2 2 0 Rotavirus non-structural protein NSP3 zf-C2H2 PF00096.21 ESA08467.1 - 7.1e-13 48.0 10.0 1.4e-06 28.2 2.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA08467.1 - 2.1e-11 43.4 14.5 1.5e-07 31.3 0.5 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA08467.1 - 2.5e-10 39.9 8.1 3.6e-06 26.9 1.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 ESA08467.1 - 1e-05 25.5 1.2 1e-05 25.5 0.8 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESA08467.1 - 7.3e-05 22.7 4.4 0.00024 21.1 0.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESA08467.1 - 0.0087 15.9 1.1 0.0087 15.9 0.8 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESA08467.1 - 0.091 12.8 1.1 0.12 12.5 0.1 1.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.1 ESA08467.1 - 0.16 11.6 5.2 4.5 7.0 0.6 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.2 ESA08467.1 - 0.22 11.3 1.8 1.5 8.6 0.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-Di19 PF05605.7 ESA08467.1 - 0.27 11.3 2.4 0.55 10.4 1.7 1.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 ESA08467.1 - 0.33 10.7 5.7 4.5 7.1 4.0 2.3 1 1 0 1 1 1 0 BED zinc finger Retrotrans_gag PF03732.12 ESA08471.1 - 0.083 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon gag protein ApoM PF11032.3 ESA08473.1 - 0.093 12.2 0.0 3.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Apolipoprotein M (ApoM) FAD_binding_3 PF01494.14 ESA08474.1 - 1.6e-15 57.0 0.0 2.2e-10 40.1 0.0 2.8 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ESA08474.1 - 0.0065 16.4 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA08474.1 - 0.011 15.5 0.0 0.039 13.7 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA08474.1 - 0.015 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase_Tyr PF07714.12 ESA08475.1 - 5.4e-09 35.5 0.0 1.1e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08475.1 - 1.6e-06 27.4 0.3 1.2e-05 24.6 0.2 2.4 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA08475.1 - 0.00089 18.9 0.2 0.15 11.6 0.0 2.6 2 1 0 2 2 2 2 BCS1 N terminal TraT PF05818.7 ESA08475.1 - 0.0038 16.6 2.8 0.023 14.1 0.1 2.7 3 0 0 3 3 3 1 Enterobacterial TraT complement resistance protein Zn_ribbon_recom PF13408.1 ESA08475.1 - 4.4 7.6 15.7 0.86 9.9 1.8 3.4 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS91 PF14319.1 ESA08475.1 - 4.8 6.7 13.4 0.1 12.0 0.9 3.1 3 0 0 3 3 3 0 Transposase zinc-binding domain zf-RanBP PF00641.13 ESA08477.1 - 1e-08 34.1 8.1 1e-08 34.1 5.6 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Abhydrolase_3 PF07859.8 ESA08478.1 - 4.4e-12 46.0 0.0 6.2e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA08478.1 - 0.019 13.5 0.0 0.022 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) FAM220 PF15487.1 ESA08481.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 FAM220 family Exo_endo_phos_2 PF14529.1 ESA08482.1 - 0.0097 15.5 0.1 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Prefoldin_3 PF13758.1 ESA08482.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Prefoldin subunit DUF1861 PF08950.5 ESA08483.1 - 0.025 13.4 0.0 0.043 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) Tropomyosin PF00261.15 ESA08483.1 - 0.89 8.6 8.0 0.094 11.7 2.3 1.7 2 0 0 2 2 2 0 Tropomyosin Pkinase_Tyr PF07714.12 ESA08485.1 - 2.4e-31 108.7 0.0 5.4e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08485.1 - 1.2e-30 106.4 1.9 1.3e-29 103.1 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain USP8_interact PF08941.5 ESA08485.1 - 0.0078 15.5 0.2 0.025 13.8 0.0 1.9 2 0 0 2 2 2 1 USP8 interacting DUF563 PF04577.9 ESA08486.1 - 0.0057 16.5 1.3 1.1 9.0 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF563) An_peroxidase PF03098.10 ESA08488.1 - 1.4e-64 218.4 0.0 1.6e-64 218.2 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase F-box-like PF12937.2 ESA08490.1 - 1.3e-06 28.0 0.1 3.9e-06 26.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like p450 PF00067.17 ESA08491.1 - 1.3e-33 116.2 0.0 1.4e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phytoreo_S7 PF07236.6 ESA08491.1 - 0.09 11.0 0.0 0.11 10.8 0.0 1.0 1 0 0 1 1 1 0 Phytoreovirus S7 protein Copper-bind PF00127.15 ESA08493.1 - 0.039 14.1 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family DUF3912 PF13051.1 ESA08493.1 - 0.047 13.4 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3912) Cupredoxin_1 PF13473.1 ESA08493.1 - 0.095 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Cupredoxin-like domain Nsp1_C PF05064.8 ESA08494.1 - 0.002 17.7 4.0 0.0073 15.9 2.8 2.0 1 0 0 1 1 1 1 Nsp1-like C-terminal region Mitofilin PF09731.4 ESA08494.1 - 0.011 14.3 14.6 0.022 13.4 10.1 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein IncA PF04156.9 ESA08494.1 - 0.069 12.7 1.7 0.13 11.8 1.2 1.4 1 0 0 1 1 1 0 IncA protein Tropomyosin PF00261.15 ESA08494.1 - 0.18 10.8 7.2 0.029 13.4 2.0 1.9 2 0 0 2 2 2 0 Tropomyosin DUF724 PF05266.9 ESA08494.1 - 0.76 9.3 9.4 0.017 14.7 1.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF724) Whib PF02467.11 ESA08495.1 - 0.029 14.6 0.1 0.043 14.1 0.1 1.2 1 0 0 1 1 1 0 Transcription factor WhiB zf-CCHC_3 PF13917.1 ESA08495.1 - 0.041 13.6 1.0 0.068 12.9 0.7 1.4 1 0 0 1 1 1 0 Zinc knuckle FdhE PF04216.7 ESA08495.1 - 0.089 12.5 0.6 0.1 12.2 0.4 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation TFIIS_C PF01096.13 ESA08495.1 - 0.18 11.4 1.7 1.7 8.3 1.1 2.2 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) Rhabdo_M1 PF03342.8 ESA08497.1 - 0.069 12.2 0.0 0.072 12.2 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) Latarcin PF10279.4 ESA08500.1 - 0.066 13.3 0.6 0.52 10.5 0.1 2.4 2 0 0 2 2 2 0 Latarcin precursor DSPc PF00782.15 ESA08501.1 - 0.01 15.3 0.8 0.078 12.5 0.0 2.4 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain SusE PF14292.1 ESA08501.1 - 0.042 13.6 0.3 0.17 11.7 0.2 2.0 1 1 0 1 1 1 0 SusE outer membrane protein MFS_1 PF07690.11 ESA08502.1 - 3.2e-20 72.1 11.3 3.7e-20 71.9 7.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA08502.1 - 9.2e-09 34.3 8.5 1.3e-08 33.9 5.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.1 ESA08502.1 - 0.00038 18.9 9.6 0.00057 18.4 6.7 1.3 1 1 0 1 1 1 1 MFS/sugar transport protein Tox-REase-7 PF15649.1 ESA08502.1 - 0.037 14.1 0.9 0.05 13.7 0.6 1.2 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 ABC2_membrane_5 PF13346.1 ESA08502.1 - 2.8 7.1 9.2 3.7 6.7 6.4 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Retrotrans_gag PF03732.12 ESA08503.1 - 0.46 10.5 5.6 0.56 10.3 0.7 3.2 2 1 0 2 2 2 0 Retrotransposon gag protein Monellin PF09200.5 ESA08504.1 - 0.017 14.7 0.4 0.13 11.9 0.0 2.4 2 1 1 3 3 3 0 Monellin FAR1 PF03101.10 ESA08505.1 - 6.4e-07 29.8 3.9 1e-06 29.1 2.7 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.6 ESA08505.1 - 0.0013 18.8 1.2 0.0022 18.1 0.9 1.4 1 0 0 1 1 1 1 Transcription factor AFT DBD_Tnp_Mut PF03108.10 ESA08505.1 - 0.024 14.2 0.0 0.053 13.1 0.0 1.7 1 0 0 1 1 1 0 MuDR family transposase WRKY PF03106.10 ESA08505.1 - 0.68 9.8 5.9 0.94 9.3 0.2 2.8 2 1 1 3 3 3 0 WRKY DNA -binding domain JAB PF01398.16 ESA08506.1 - 5.3e-32 109.9 0.3 8.6e-32 109.2 0.2 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESA08506.1 - 1.7e-06 27.5 0.0 2.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 ESA08506.1 - 0.012 15.1 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) DUF2271 PF10029.4 ESA08506.1 - 0.066 12.7 0.2 9.6 5.6 0.0 2.6 2 0 0 2 2 2 0 Predicted periplasmic protein (DUF2271) Ribosomal_L14 PF00238.14 ESA08508.1 - 2.5e-42 143.4 0.5 3.4e-42 143.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e MCD PF05292.6 ESA08509.1 - 3e-95 318.9 0.0 3.7e-95 318.6 0.0 1.1 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase (MCD) MgtE_N PF03448.12 ESA08509.1 - 0.017 15.3 0.2 2.2 8.6 0.1 2.6 2 0 0 2 2 2 0 MgtE intracellular N domain SWIRM PF04433.12 ESA08510.1 - 4.7e-08 33.0 0.5 2e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 SWIRM domain Hema_HEFG PF02710.9 ESA08510.1 - 0.038 14.2 0.3 0.12 12.6 0.0 1.7 1 1 1 2 2 2 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein DUF1643 PF07799.7 ESA08510.1 - 0.053 13.2 0.1 0.081 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Fork_head PF00250.13 ESA08514.1 - 1.8e-33 114.4 0.2 5.6e-33 112.8 0.1 1.6 1 1 0 1 1 1 1 Fork head domain DUF3445 PF11927.3 ESA08514.1 - 0.047 13.0 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) SNF5 PF04855.7 ESA08515.1 - 1e-77 260.9 1.2 1e-77 260.9 0.8 2.5 2 0 0 2 2 2 1 SNF5 / SMARCB1 / INI1 GATA PF00320.22 ESA08515.1 - 1.5e-06 27.4 4.9 4e-06 26.0 3.4 1.7 1 0 0 1 1 1 1 GATA zinc finger Sel1 PF08238.7 ESA08518.1 - 7.9e-69 226.5 7.1 2.4e-12 47.0 0.2 7.1 7 0 0 7 7 7 7 Sel1 repeat MIT PF04212.13 ESA08518.1 - 0.00023 20.9 15.0 2.3 8.1 0.1 5.5 5 2 0 5 5 5 4 MIT (microtubule interacting and transport) domain EF-hand_10 PF14788.1 ESA08518.1 - 0.00031 20.3 0.0 23 4.7 0.0 4.5 4 0 0 4 4 4 0 EF hand NSF PF02071.15 ESA08518.1 - 0.031 14.7 5.7 4.5 8.2 0.1 5.6 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat G10 PF01125.12 ESA08518.1 - 0.04 13.4 0.1 0.082 12.4 0.1 1.5 1 0 0 1 1 1 0 G10 protein TPR_6 PF13174.1 ESA08518.1 - 0.079 13.4 4.4 25 5.6 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08518.1 - 0.48 10.0 24.6 2.1 8.0 0.4 6.0 1 1 3 4 4 4 0 TPR repeat TPR_7 PF13176.1 ESA08518.1 - 3.4 7.6 5.9 13 5.8 0.1 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat Zn_clus PF00172.13 ESA08520.1 - 3.2e-12 46.1 12.7 4.9e-12 45.5 8.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2318 PF10080.4 ESA08520.1 - 0.13 12.0 1.8 0.17 11.7 1.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Peptidase_M24 PF00557.19 ESA08521.1 - 1.9e-54 184.4 0.0 2.6e-54 183.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 ESA08521.1 - 2.1e-35 121.0 0.0 4e-35 120.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain ADH_N PF08240.7 ESA08522.1 - 7.6e-30 102.8 4.7 1.8e-29 101.7 3.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESA08522.1 - 2.9e-22 78.5 0.3 4.4e-22 78.0 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA08522.1 - 0.00012 22.9 0.0 0.00024 22.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.9 ESA08522.1 - 0.001 18.5 0.1 0.0015 17.9 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MTS PF05175.9 ESA08522.1 - 0.0051 16.2 0.0 0.0098 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain AlaDh_PNT_C PF01262.16 ESA08522.1 - 0.013 15.1 0.2 0.02 14.4 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 ESA08522.1 - 0.12 12.0 0.2 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.16 ESA08522.1 - 0.42 10.4 3.7 1.9 8.2 0.2 2.7 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Methyltransf_23 PF13489.1 ESA08523.1 - 1.4e-13 50.8 0.1 2.6e-13 49.9 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08523.1 - 1e-11 45.1 0.0 2.8e-11 43.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08523.1 - 9.4e-11 41.5 1.2 1.8e-10 40.6 0.1 1.9 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08523.1 - 2.7e-06 27.6 0.0 8.3e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA08523.1 - 4.1e-06 27.3 0.0 7.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08523.1 - 5.5e-06 26.7 0.0 1.2e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 ESA08523.1 - 1.1e-05 24.5 0.0 1.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) MTS PF05175.9 ESA08523.1 - 2.4e-05 23.8 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.8 ESA08523.1 - 0.0023 17.2 0.0 0.0035 16.6 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 ESA08523.1 - 0.0083 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA08523.1 - 0.0087 15.1 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Pkinase_Tyr PF07714.12 ESA08524.1 - 0.00021 20.4 0.0 0.0003 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MRVI1 PF05781.7 ESA08526.1 - 0.0066 14.9 0.9 0.0066 14.9 0.6 1.0 1 0 0 1 1 1 1 MRVI1 protein GCOM2 PF15328.1 ESA08526.1 - 0.026 14.2 1.8 0.029 14.1 1.2 1.0 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 FAM60A PF15396.1 ESA08526.1 - 0.055 13.1 4.4 0.058 13.1 3.0 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Neogenin_C PF06583.7 ESA08526.1 - 0.057 12.9 7.1 0.061 12.8 4.9 1.0 1 0 0 1 1 1 0 Neogenin C-terminus AUX_IAA PF02309.11 ESA08526.1 - 0.16 11.6 3.2 0.17 11.5 2.2 1.0 1 0 0 1 1 1 0 AUX/IAA family NPR3 PF03666.8 ESA08526.1 - 0.38 9.2 4.7 0.39 9.2 3.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.7 ESA08526.1 - 1.3 6.8 5.5 1.3 6.8 3.8 1.0 1 0 0 1 1 1 0 Nop14-like family Secretin_N_2 PF07655.8 ESA08526.1 - 2.7 8.4 12.9 3.1 8.2 8.9 1.1 1 0 0 1 1 1 0 Secretin N-terminal domain CDC45 PF02724.9 ESA08526.1 - 4.5 5.1 9.5 4.5 5.1 6.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Fmp27 PF10344.4 ESA08526.1 - 7.6 4.0 10.7 7.9 4.0 7.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 BUD22 PF09073.5 ESA08526.1 - 8.9 5.2 14.6 9.2 5.2 10.1 1.0 1 0 0 1 1 1 0 BUD22 CAF-1_p150 PF11600.3 ESA08526.1 - 9.8 5.4 14.4 11 5.3 9.9 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal FTZ PF03867.9 ESA08528.1 - 0.085 12.0 0.1 0.085 12.0 0.1 1.0 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region SR-25 PF10500.4 ESA08528.1 - 0.34 10.3 7.6 0.35 10.3 5.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cwf_Cwc_15 PF04889.7 ESA08529.1 - 0.18 11.4 3.9 0.19 11.3 2.7 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAR1 PF03101.10 ESA08530.1 - 4.6e-06 27.0 0.5 7.9e-06 26.3 0.4 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain Arc PF03869.9 ESA08530.1 - 0.03 13.9 0.1 4 7.1 0.0 2.4 2 0 0 2 2 2 0 Arc-like DNA binding domain SLA_LP_auto_ag PF05889.8 ESA08532.1 - 0.017 13.6 0.0 0.018 13.4 0.0 1.0 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Antigen_Bd37 PF11641.3 ESA08535.1 - 0.0069 15.6 3.2 1.2 8.3 0.1 2.2 1 1 1 2 2 2 2 Glycosylphosphatidylinositol-anchored merozoite surface protein Dynamin_N PF00350.18 ESA08535.1 - 0.056 13.2 0.4 0.089 12.6 0.2 1.3 1 1 0 1 1 1 0 Dynamin family Kinetocho_Slk19 PF12709.2 ESA08535.1 - 0.091 12.8 2.8 0.2 11.7 2.0 1.6 1 0 0 1 1 1 0 Central kinetochore-associated ICMT PF04140.9 ESA08536.1 - 2.5e-10 40.4 4.3 1.1e-09 38.2 0.2 2.9 1 1 2 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESA08536.1 - 1e-08 35.1 6.8 7.2e-07 29.2 0.2 3.0 3 0 0 3 3 3 2 Phospholipid methyltransferase Corona_7 PF02398.11 ESA08536.1 - 0.0087 16.5 0.9 0.016 15.6 0.2 1.7 2 0 0 2 2 2 1 Coronavirus protein 7 DUF1035 PF06281.7 ESA08536.1 - 0.035 13.8 0.2 0.085 12.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) GBP PF02263.14 ESA08538.1 - 6.5e-11 41.7 0.0 7.7e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 ESA08538.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 2 0 0 2 2 2 0 Dynamin family GBP PF02263.14 ESA08539.1 - 5.5e-11 42.0 0.0 6.7e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 ESA08539.1 - 0.082 12.7 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 Dynamin family Methyltransf_23 PF13489.1 ESA08540.1 - 1.2e-14 54.3 0.0 1.8e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08540.1 - 1.7e-12 47.6 0.0 3.1e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08540.1 - 2.1e-09 37.1 0.0 9.9e-09 34.9 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08540.1 - 8.9e-08 32.4 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA08540.1 - 2.3e-06 26.8 0.0 0.00014 20.9 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESA08540.1 - 3.7e-06 27.4 0.0 7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08540.1 - 9.9e-06 25.9 0.0 2.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 ESA08540.1 - 2.3e-05 23.7 0.0 0.0021 17.3 0.0 2.6 2 1 1 3 3 3 1 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.13 ESA08540.1 - 0.00099 18.2 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 ESA08540.1 - 0.13 12.3 0.0 0.48 10.4 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 ESA08540.1 - 0.14 11.5 0.0 0.39 10.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain F-box-like PF12937.2 ESA08541.1 - 0.00011 21.7 1.2 0.00036 20.1 0.8 1.9 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA08542.1 - 0.058 13.1 2.6 3.3 7.5 0.7 3.2 1 1 2 3 3 3 0 Leucine rich repeat Pkinase_Tyr PF07714.12 ESA08544.1 - 3.4e-27 95.1 2.4 8.8e-20 70.8 0.1 3.3 1 1 2 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA08544.1 - 7.7e-23 80.9 2.8 1.7e-18 66.7 0.2 3.7 2 1 2 4 4 4 2 Protein kinase domain Kdo PF06293.9 ESA08544.1 - 0.0035 16.4 0.1 0.0056 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA08544.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA08544.1 - 0.017 14.3 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Macoilin PF09726.4 ESA08544.1 - 0.027 12.7 0.1 0.029 12.6 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein RIO1 PF01163.17 ESA08544.1 - 0.041 13.2 0.1 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PI31_Prot_N PF11566.3 ESA08545.1 - 0.005 16.4 0.2 0.0097 15.5 0.2 1.7 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal ALO PF04030.9 ESA08546.1 - 2.5e-12 46.9 0.3 3.4e-12 46.5 0.2 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESA08546.1 - 0.0001 21.8 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DUF3837 PF12939.2 ESA08546.1 - 0.044 13.7 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) Chol_subst-bind PF09129.6 ESA08546.1 - 0.065 12.3 0.0 4.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Cholesterol oxidase, substrate-binding HypA PF01155.14 ESA08549.1 - 1.3e-12 47.4 6.2 0.037 13.6 0.0 4.3 4 0 0 4 4 4 4 Hydrogenase expression/synthesis hypA family TF_Zn_Ribbon PF08271.7 ESA08549.1 - 5e-05 22.5 13.1 0.21 10.9 0.2 4.6 4 0 0 4 4 4 2 TFIIB zinc-binding DZR PF12773.2 ESA08549.1 - 0.00045 19.9 25.3 0.46 10.3 1.6 4.4 4 0 0 4 4 4 4 Double zinc ribbon DUF1657 PF07870.6 ESA08549.1 - 0.0012 18.4 2.4 26 4.6 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1657) BLOC1_2 PF10046.4 ESA08549.1 - 0.0021 18.1 22.4 0.6 10.2 0.2 5.7 6 0 0 6 6 6 3 Biogenesis of lysosome-related organelles complex-1 subunit 2 zinc_ribbon_2 PF13240.1 ESA08549.1 - 0.016 14.6 36.5 1 8.9 2.0 4.9 4 0 0 4 4 4 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 ESA08549.1 - 0.035 14.0 32.0 0.18 11.7 1.5 4.6 4 0 0 4 4 4 0 Zinc ribbon domain DUF2321 PF10083.4 ESA08549.1 - 0.065 12.7 15.4 5.6 6.4 0.1 4.5 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2321) GCC2_GCC3 PF07699.8 ESA08549.1 - 0.26 10.9 42.3 0.63 9.6 3.4 4.9 4 1 0 4 4 4 0 GCC2 and GCC3 DUF1906 PF08924.6 ESA08549.1 - 0.57 10.0 5.7 34 4.3 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1906) Prok-RING_1 PF14446.1 ESA08549.1 - 1.3 8.8 25.8 0.84 9.4 0.8 4.4 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 DUF1610 PF07754.6 ESA08549.1 - 3.8 7.7 27.4 4.2 7.5 0.6 4.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1610) PIG-H PF10181.4 ESA08549.1 - 6 6.5 7.5 21 4.8 0.1 3.5 4 0 0 4 4 4 0 GPI-GlcNAc transferase complex, PIG-H component DUF4379 PF14311.1 ESA08549.1 - 9.3 6.1 17.2 25 4.7 0.1 5.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4379) Na_H_Exchanger PF00999.16 ESA08550.1 - 1.4e-37 129.1 20.0 1.9e-37 128.7 13.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4118 PF13493.1 ESA08550.1 - 0.024 14.8 23.1 0.37 11.0 0.7 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4118) MgtE PF01769.11 ESA08550.1 - 4.7 7.4 18.9 0.13 12.5 4.9 3.0 2 1 1 3 3 3 0 Divalent cation transporter DUF1352 PF07086.7 ESA08550.1 - 4.9 6.7 7.6 0.85 9.2 1.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1352) DUF3353 PF11833.3 ESA08550.1 - 6.5 6.1 7.1 2.3 7.6 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3353) API5 PF05918.6 ESA08553.1 - 0.15 10.5 3.0 0.15 10.4 2.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) HECT PF00632.20 ESA08554.1 - 5e-06 25.9 4.3 1.9e-05 23.9 3.0 2.3 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) KH_1 PF00013.24 ESA08556.1 - 4.2e-06 26.2 1.7 9.6e-06 25.1 1.1 1.8 1 1 0 1 1 1 1 KH domain KH_3 PF13014.1 ESA08556.1 - 4.4e-06 26.1 1.7 2.4e-05 23.8 0.2 2.4 1 1 1 2 2 2 1 KH domain KH_4 PF13083.1 ESA08556.1 - 0.009 15.6 1.0 0.041 13.5 0.0 2.2 2 0 0 2 2 2 1 KH domain Phage_F PF02305.12 ESA08556.1 - 0.013 14.0 0.1 0.016 13.7 0.1 1.1 1 0 0 1 1 1 0 Capsid protein (F protein) PmbA_TldD PF01523.11 ESA08556.1 - 0.036 13.3 0.3 0.039 13.2 0.2 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase KH_2 PF07650.12 ESA08556.1 - 0.35 10.4 0.1 0.35 10.4 0.1 2.6 3 0 0 3 3 3 0 KH domain Ribosomal_S6 PF01250.12 ESA08556.1 - 3.7 7.4 7.7 9.8 6.1 2.2 2.5 1 1 2 3 3 3 0 Ribosomal protein S6 Tropomyosin PF00261.15 ESA08560.1 - 0.006 15.7 3.8 0.0089 15.1 2.6 1.2 1 0 0 1 1 1 1 Tropomyosin APG6 PF04111.7 ESA08560.1 - 0.0089 15.1 4.8 0.014 14.4 3.3 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 TACC PF05010.9 ESA08560.1 - 0.01 15.5 6.5 0.014 15.1 4.5 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) V_ATPase_I PF01496.14 ESA08560.1 - 0.013 13.3 5.1 0.016 13.1 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fmp27_SW PF10305.4 ESA08560.1 - 0.02 15.3 0.7 0.02 15.3 0.5 1.7 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF3892 PF13031.1 ESA08560.1 - 0.025 14.9 0.8 0.05 14.0 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) Reo_sigmaC PF04582.7 ESA08560.1 - 0.028 13.6 2.8 0.034 13.3 2.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF16 PF01519.11 ESA08560.1 - 0.034 14.3 2.2 0.084 13.1 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.7 ESA08560.1 - 0.13 12.6 3.1 1.4 9.3 0.4 2.2 1 1 0 2 2 2 0 SlyX DUF724 PF05266.9 ESA08560.1 - 0.2 11.2 5.1 0.07 12.7 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Nbl1_Borealin_N PF10444.4 ESA08560.1 - 0.38 10.1 2.5 0.28 10.5 0.5 1.7 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal FlxA PF14282.1 ESA08560.1 - 0.49 10.3 12.6 0.041 13.8 4.1 2.2 1 1 1 2 2 2 0 FlxA-like protein TBPIP PF07106.8 ESA08560.1 - 0.77 9.2 11.8 0.93 9.0 7.3 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Prefoldin PF02996.12 ESA08560.1 - 1.4 8.6 6.7 4.4 6.9 1.4 2.4 1 1 2 3 3 3 0 Prefoldin subunit DUF2951 PF11166.3 ESA08560.1 - 2.7 7.9 7.4 2.5 8.0 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) Nup54 PF13874.1 ESA08560.1 - 2.9 7.5 7.6 1.7 8.3 1.7 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TMF_DNA_bd PF12329.3 ESA08560.1 - 3.2 7.6 9.7 1.4 8.7 2.2 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Mitofilin PF09731.4 ESA08560.1 - 3.6 6.1 11.1 3 6.3 6.5 1.5 1 1 0 1 1 1 0 Mitochondrial inner membrane protein Pkinase_Tyr PF07714.12 ESA08561.1 - 1.3e-45 155.4 0.1 1.9e-45 154.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08561.1 - 1.6e-45 155.3 1.0 1.6e-45 155.3 0.7 1.8 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA08561.1 - 0.0019 17.5 0.2 0.004 16.5 0.2 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA08561.1 - 0.0053 15.8 0.1 0.0099 14.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3873 PF12989.2 ESA08562.1 - 0.025 14.6 0.1 0.029 14.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) AKAP95 PF04988.7 ESA08562.1 - 0.038 13.7 0.4 0.049 13.4 0.3 1.3 1 1 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) DUF2004 PF09406.5 ESA08562.1 - 0.058 13.4 0.2 0.063 13.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) zf-C2H2 PF00096.21 ESA08563.1 - 7.1e-17 60.6 32.5 0.0015 18.7 1.9 5.9 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA08563.1 - 3e-13 49.0 21.5 0.0027 17.9 0.4 5.4 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA08563.1 - 5.3e-13 48.5 49.3 3.7e-07 30.0 0.7 6.8 7 0 0 7 7 7 4 Zinc-finger double domain Ogr_Delta PF04606.7 ESA08563.1 - 0.06 13.0 0.3 0.06 13.0 0.2 3.3 2 2 1 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2_6 PF13912.1 ESA08563.1 - 0.42 10.5 19.1 0.91 9.5 1.4 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger FANCL_C PF11793.3 ESA08563.1 - 1.8 8.6 12.7 1.3 9.0 1.4 4.5 2 1 2 4 4 4 0 FANCL C-terminal domain ORC2 PF04084.9 ESA08564.1 - 3.4e-40 137.8 2.2 4.9e-40 137.3 1.6 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 HA2 PF04408.18 ESA08565.1 - 3.7e-25 87.8 0.0 3.7e-25 87.8 0.0 3.8 4 1 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESA08565.1 - 6.6e-25 87.1 0.1 3.7e-24 84.7 0.0 2.3 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESA08565.1 - 3.5e-12 46.0 0.0 1.3e-11 44.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA08565.1 - 2.6e-08 33.5 0.1 7e-08 32.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESA08565.1 - 1.3e-05 25.3 0.0 4.7e-05 23.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA08565.1 - 0.012 14.5 0.0 0.024 13.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ESA08565.1 - 0.029 13.8 0.0 0.069 12.6 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_19 PF13245.1 ESA08565.1 - 0.086 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain DUF2046 PF09755.4 ESA08566.1 - 7.8e-30 103.8 41.3 1.8e-29 102.5 16.0 3.5 2 1 2 4 4 4 3 Uncharacterized conserved protein H4 (DUF2046) NTPase_I-T PF01931.13 ESA08566.1 - 0.015 15.0 0.8 1.5 8.5 0.5 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF84 Sel1 PF08238.7 ESA08567.1 - 2.3e-11 43.9 1.5 7.2e-07 29.6 0.1 2.6 3 1 0 3 3 3 2 Sel1 repeat Sel1 PF08238.7 ESA08569.1 - 9e-98 318.5 45.8 4.5e-09 36.6 0.0 14.1 14 0 0 14 14 14 13 Sel1 repeat TPR_6 PF13174.1 ESA08569.1 - 3.2e-10 39.7 24.8 0.79 10.3 0.0 10.3 12 0 0 12 12 12 4 Tetratricopeptide repeat Fcf2 PF08698.6 ESA08569.1 - 1.8 8.5 6.5 14 5.7 0.0 3.7 4 0 0 4 4 4 0 Fcf2 pre-rRNA processing DUF1934 PF09148.5 ESA08571.1 - 0.0068 16.1 1.7 0.0077 15.9 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1934) CDC73 PF05179.9 ESA08571.1 - 0.02 14.2 0.1 0.026 13.8 0.1 1.1 1 0 0 1 1 1 0 RNA pol II accessory factor, Cdc73 family DDE_Tnp_4 PF13359.1 ESA08572.1 - 2.5e-06 27.1 0.1 0.00037 20.1 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease Myb_DNA-bind_4 PF13837.1 ESA08573.1 - 2e-05 24.6 1.2 2e-05 24.6 0.8 2.9 2 1 1 3 3 3 1 Myb/SANT-like DNA-binding domain DUF4488 PF14869.1 ESA08573.1 - 0.12 11.9 2.8 0.18 11.3 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) MADF_DNA_bdg PF10545.4 ESA08573.1 - 1.2 9.3 10.2 0.87 9.8 0.7 2.5 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like UvsY PF11056.3 ESA08575.1 - 0.024 14.7 0.1 3.9 7.5 0.0 2.5 1 1 1 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY DUF4298 PF14131.1 ESA08575.1 - 0.085 12.7 0.8 1 9.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Pkinase_Tyr PF07714.12 ESA08577.1 - 6.3e-08 31.9 0.0 7.8e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08577.1 - 0.12 11.5 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Baculo_PP31 PF05311.6 ESA08577.1 - 0.83 8.8 4.7 0.37 10.0 1.6 1.6 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) Pkinase_Tyr PF07714.12 ESA08578.1 - 0.0074 15.3 0.0 0.0099 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RVT_1 PF00078.22 ESA08580.1 - 5.1e-08 32.5 0.1 5.6e-08 32.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESA08582.1 - 0.0098 15.5 0.1 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase NUFIP1 PF10453.4 ESA08583.1 - 6.2e-12 44.8 1.0 6.2e-12 44.8 0.7 2.3 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) SprT-like PF10263.4 ESA08583.1 - 4.5e-05 23.1 1.0 8.3e-05 22.2 0.7 1.4 1 0 0 1 1 1 1 SprT-like family SUKH-3 PF14433.1 ESA08583.1 - 0.05 13.3 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 SUKH-3 immunity protein FUR PF01475.14 ESA08583.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.3 3 0 0 3 3 3 0 Ferric uptake regulator family Evr1_Alr PF04777.8 ESA08583.1 - 0.4 10.5 7.3 0.045 13.6 1.0 2.3 2 1 0 2 2 2 0 Erv1 / Alr family Inhibitor_I67 PF11405.3 ESA08584.1 - 0.045 13.7 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 Bromelain inhibitor VI LRR_4 PF12799.2 ESA08584.1 - 0.18 11.4 2.2 9.4 5.9 1.5 2.3 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) Inhibitor_I53 PF11714.3 ESA08585.1 - 0.08 12.9 0.1 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Thrombin inhibitor Madanin DUF1626 PF07788.6 ESA08585.1 - 0.12 12.1 0.6 0.24 11.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1626) Fungal_lectin PF07938.7 ESA08585.1 - 0.14 11.3 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal fucose-specific lectin HMG_box PF00505.14 ESA08586.1 - 4.1e-08 33.3 0.2 1.1e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box Bac_DnaA PF00308.13 ESA08586.1 - 0.038 13.6 0.1 0.08 12.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial dnaA protein Cullin PF00888.17 ESA08588.1 - 9.1e-07 27.7 0.7 1e-06 27.6 0.5 1.1 1 0 0 1 1 1 1 Cullin family Pkinase PF00069.20 ESA08590.1 - 3.6e-29 101.7 0.1 3.7e-29 101.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08590.1 - 6e-28 97.6 0.0 6.9e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA08590.1 - 0.005 15.8 0.0 0.0074 15.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA08590.1 - 0.017 14.4 0.2 0.022 14.1 0.2 1.1 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 ESA08590.1 - 0.027 13.5 0.1 0.035 13.1 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA08590.1 - 0.031 13.6 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ESA08590.1 - 0.13 11.9 0.3 0.16 11.6 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA08591.1 - 5.8e-78 255.6 53.1 2.3e-08 34.3 0.0 13.1 13 0 0 13 13 13 11 Sel1 repeat TPR_6 PF13174.1 ESA08591.1 - 7.2e-09 35.5 22.4 0.44 11.1 0.0 9.7 10 0 0 10 10 10 5 Tetratricopeptide repeat HMG_box PF00505.14 ESA08592.1 - 0.0021 18.2 2.3 0.0037 17.5 1.6 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08592.1 - 0.0043 17.3 2.9 0.0071 16.6 2.0 1.4 1 0 0 1 1 1 1 HMG-box domain Lipoprotein_19 PF13617.1 ESA08592.1 - 0.17 11.5 0.4 0.31 10.6 0.3 1.4 1 0 0 1 1 1 0 YnbE-like lipoprotein Abhydrolase_6 PF12697.2 ESA08593.1 - 1.3e-18 67.6 0.0 2e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA08593.1 - 1.2e-10 41.3 0.0 3.3e-10 39.8 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA08593.1 - 5.4e-08 32.6 0.0 7.5e-06 25.6 0.0 3.2 2 2 0 2 2 2 1 alpha/beta hydrolase fold RRM_1 PF00076.17 ESA08594.1 - 1.4e-08 34.2 0.0 2.2e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA08594.1 - 1.2e-05 25.0 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA08594.1 - 1.6e-05 24.8 0.0 2.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA08594.1 - 0.029 14.2 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Dimer_Tnp_hAT PF05699.9 ESA08595.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Tmemb_18A PF09771.4 ESA08597.1 - 0.02 14.8 2.2 0.045 13.7 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 188 Choline_transpo PF04515.7 ESA08598.1 - 9.3e-21 73.9 0.6 1e-20 73.7 0.4 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter Tom7 PF08038.7 ESA08598.1 - 0.23 10.9 2.7 0.47 9.9 1.9 1.5 1 0 0 1 1 1 0 TOM7 family ATP_bind_3 PF01171.15 ESA08599.1 - 3.2e-14 52.8 0.0 4.7e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.11 ESA08599.1 - 0.02 13.4 0.0 0.029 12.9 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase DUF4428 PF14471.1 ESA08599.1 - 0.051 13.3 1.4 0.12 12.1 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Asn_synthase PF00733.16 ESA08599.1 - 0.065 12.7 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase PAPS_reduct PF01507.14 ESA08599.1 - 0.068 12.9 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family TF_Zn_Ribbon PF08271.7 ESA08599.1 - 0.12 11.7 3.7 0.17 11.2 0.3 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding MIP PF00230.15 ESA08600.1 - 8.1e-13 48.3 0.8 1e-12 48.0 0.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein BTB PF00651.26 ESA08601.1 - 2.8e-14 53.0 0.4 5.7e-14 52.0 0.3 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA08601.1 - 3.2e-05 23.9 0.2 7.1e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA08601.1 - 9e-05 22.2 0.1 0.00061 19.6 0.1 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch GPP34 PF05719.6 ESA08602.1 - 4e-32 111.9 0.0 6.5e-32 111.2 0.0 1.4 1 1 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Phage_integrase PF00589.17 ESA08602.1 - 0.12 12.0 0.1 0.75 9.4 0.0 2.0 1 1 0 1 1 1 0 Phage integrase family HMG_box PF00505.14 ESA08605.1 - 3.4e-07 30.4 0.3 7.7e-07 29.2 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08605.1 - 0.035 14.4 0.3 0.076 13.3 0.2 1.5 1 0 0 1 1 1 0 HMG-box domain Tn7_Tnp_TnsA_C PF08721.6 ESA08606.1 - 0.12 12.3 0.1 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 TnsA endonuclease C terminal Tn7_Tnp_TnsA_C PF08721.6 ESA08607.1 - 0.37 10.8 2.0 7.3 6.6 0.1 2.5 1 1 1 2 2 2 0 TnsA endonuclease C terminal VGCC_beta4Aa_N PF12052.3 ESA08607.1 - 2.1 8.2 6.5 1.5 8.7 0.2 2.8 3 0 0 3 3 3 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal DUF3403 PF11883.3 ESA08607.1 - 5.9 7.2 9.6 12 6.2 0.5 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3403) DUF2208 PF09973.4 ESA08608.1 - 0.041 13.1 0.4 0.041 13.1 0.3 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) PDR_CDR PF06422.7 ESA08609.1 - 0.25 11.0 4.8 0.49 10.0 0.6 2.7 2 0 0 2 2 2 0 CDR ABC transporter Neur_chan_memb PF02932.11 ESA08609.1 - 0.32 10.8 8.0 0.038 13.8 2.1 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_S8 PF00082.17 ESA08610.1 - 1.5e-37 129.3 10.8 2e-37 128.8 7.5 1.1 1 0 0 1 1 1 1 Subtilase family B3_4 PF03483.12 ESA08610.1 - 0.081 12.3 0.0 0.25 10.7 0.0 1.8 1 0 0 1 1 1 0 B3/4 domain GHMP_kinases_C PF08544.8 ESA08610.1 - 0.13 12.4 0.1 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 GHMP kinases C terminal DDE_3 PF13358.1 ESA08611.1 - 2.5e-05 24.0 0.0 3.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease GAT PF03127.9 ESA08612.1 - 0.11 12.5 0.2 0.73 9.8 0.0 1.9 2 0 0 2 2 2 0 GAT domain Glyco_hydro_42C PF08533.5 ESA08613.1 - 0.01 15.3 0.2 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain DUF2140 PF09911.4 ESA08613.1 - 0.018 14.2 0.4 0.02 14.1 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) ABC_transp_aux PF09822.4 ESA08613.1 - 0.036 13.5 0.0 0.038 13.4 0.0 1.0 1 0 0 1 1 1 0 ABC-type uncharacterized transport system DNA_pol3_a_NII PF11490.3 ESA08613.1 - 0.037 13.6 0.8 0.039 13.5 0.5 1.1 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II XendoU PF09412.5 ESA08613.1 - 0.11 11.5 0.1 0.11 11.5 0.1 1.0 1 0 0 1 1 1 0 Endoribonuclease XendoU Mito_carr PF00153.22 ESA08616.1 - 5.4e-58 192.7 1.4 1.7e-18 66.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SNARE PF05739.14 ESA08617.1 - 8.8e-12 44.5 5.2 8.8e-12 44.5 3.6 2.4 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 ESA08617.1 - 1.9e-06 27.9 1.7 1.9e-06 27.9 1.2 2.7 3 0 0 3 3 2 1 Syntaxin GP41 PF00517.12 ESA08617.1 - 0.00012 21.7 5.6 0.00012 21.7 3.9 3.3 2 1 1 4 4 4 1 Retroviral envelope protein Use1 PF09753.4 ESA08617.1 - 0.00018 21.0 12.6 0.00028 20.3 8.7 1.3 1 1 0 1 1 1 1 Membrane fusion protein Use1 MCPsignal PF00015.16 ESA08617.1 - 0.0003 20.3 6.4 0.0003 20.3 4.4 2.4 2 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4094 PF13334.1 ESA08617.1 - 0.012 15.9 1.3 0.012 15.9 0.9 3.0 4 1 0 4 4 4 0 Domain of unknown function (DUF4094) Corona_S2 PF01601.11 ESA08617.1 - 0.014 13.5 7.6 0.0095 14.0 4.2 1.5 1 1 0 1 1 1 0 Coronavirus S2 glycoprotein OppC_N PF12911.2 ESA08617.1 - 0.051 12.9 0.2 0.092 12.1 0.2 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Sigma_reg_N PF13800.1 ESA08617.1 - 0.078 13.0 1.9 0.38 10.8 1.3 2.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Spectrin PF00435.16 ESA08617.1 - 0.097 12.9 14.6 1.6 9.0 0.1 3.1 3 0 0 3 3 3 0 Spectrin repeat ODV-E18 PF10717.4 ESA08617.1 - 0.11 11.8 0.2 0.11 11.8 0.2 2.3 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 Occludin_ELL PF07303.8 ESA08617.1 - 0.17 12.6 0.2 0.17 12.6 0.1 3.2 1 1 1 3 3 2 0 Occludin homology domain Gp-FAR-1 PF05823.7 ESA08617.1 - 0.5 10.3 9.7 0.32 10.9 3.1 2.4 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF3753 PF12575.3 ESA08617.1 - 0.53 10.1 4.4 1.4 8.7 3.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) D5_N PF08706.6 ESA08617.1 - 0.59 10.2 4.5 1.7 8.7 2.8 2.1 1 1 0 1 1 1 0 D5 N terminal like GAS PF13851.1 ESA08617.1 - 0.65 9.1 20.5 0.14 11.3 8.6 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Rifin_STEVOR PF02009.11 ESA08617.1 - 0.76 9.3 18.3 0.14 11.7 9.3 2.0 1 1 0 2 2 2 0 Rifin/stevor family Vac_Fusion PF02346.11 ESA08617.1 - 0.85 9.0 4.7 3.9 6.9 0.2 3.0 3 0 0 3 3 3 0 Chordopoxvirus fusion protein Dak2 PF02734.12 ESA08617.1 - 0.87 9.2 4.7 0.55 9.8 1.5 1.9 3 0 0 3 3 3 0 DAK2 domain DUF3139 PF11337.3 ESA08617.1 - 1.1 9.5 4.2 0.78 10.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Baculo_11_kDa PF06143.6 ESA08617.1 - 1.7 8.0 5.4 0.63 9.4 0.7 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family V-SNARE PF05008.10 ESA08617.1 - 6.5 6.9 15.3 6.2 7.0 2.7 3.7 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Syntaxin PF00804.20 ESA08618.1 - 1.2e-05 25.3 5.2 1.4e-05 25.1 1.2 2.3 2 0 0 2 2 2 1 Syntaxin V-SNARE PF05008.10 ESA08618.1 - 0.16 12.1 4.5 0.49 10.5 0.8 2.9 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Syntaxin_2 PF14523.1 ESA08618.1 - 0.25 11.3 5.7 0.3 11.1 1.6 2.3 2 0 0 2 2 2 0 Syntaxin-like protein DUF2408 PF10303.4 ESA08618.1 - 3 7.9 8.5 0.88 9.6 2.9 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2408) Occludin_ELL PF07303.8 ESA08618.1 - 3.1 8.5 9.5 1.4 9.6 0.8 3.3 2 1 1 3 3 3 0 Occludin homology domain Syntaxin PF00804.20 ESA08619.1 - 0.0022 18.1 6.3 0.0022 18.1 4.3 2.7 1 1 2 3 3 3 1 Syntaxin Occludin_ELL PF07303.8 ESA08619.1 - 0.0089 16.7 2.0 0.0089 16.7 1.4 3.2 1 1 2 3 3 3 1 Occludin homology domain Catalase-rel PF06628.7 ESA08619.1 - 0.011 15.5 1.5 0.055 13.3 0.1 2.8 2 1 0 2 2 2 0 Catalase-related immune-responsive DUF479 PF04336.7 ESA08619.1 - 0.054 13.6 3.2 1.8 8.7 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function, DUF479 ApoC-I PF04691.7 ESA08619.1 - 0.11 12.2 1.8 0.86 9.3 0.0 3.0 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Complex1_LYR_2 PF13233.1 ESA08619.1 - 2 8.9 9.4 13 6.3 6.5 2.3 1 1 0 1 1 1 0 Complex1_LYR-like DUF2203 PF09969.4 ESA08619.1 - 5.5 7.2 12.3 1.5 9.1 1.2 3.1 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) TPR_11 PF13414.1 ESA08620.1 - 3.3e-38 129.1 18.2 3.6e-09 36.1 0.2 6.5 6 0 0 6 6 6 6 TPR repeat TPR_2 PF07719.12 ESA08620.1 - 2.2e-28 95.8 15.1 0.00028 20.5 0.1 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESA08620.1 - 1.3e-23 81.5 31.0 0.0014 18.1 0.0 10.3 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_9 PF13371.1 ESA08620.1 - 4e-19 68.2 0.4 2e-05 24.3 0.1 6.1 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESA08620.1 - 2.1e-11 42.7 17.0 0.027 14.2 0.0 8.5 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA08620.1 - 2.7e-11 43.7 4.0 0.024 15.2 0.1 5.9 4 1 2 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08620.1 - 1.8e-10 40.6 17.1 0.1 12.5 0.3 7.1 3 2 5 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESA08620.1 - 3.4e-10 39.6 1.9 0.39 11.4 0.0 5.7 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA08620.1 - 4.2e-08 32.7 18.7 0.29 11.4 0.0 8.6 9 1 1 10 10 9 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA08620.1 - 2.2e-07 30.9 12.5 0.013 15.5 1.3 5.2 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 ESA08620.1 - 1.8e-06 27.2 0.1 0.0095 15.0 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA08620.1 - 0.00011 22.4 9.1 6.4 7.1 0.0 5.5 4 2 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA08620.1 - 0.0027 16.9 19.9 0.06 12.5 0.7 6.7 7 0 0 7 7 7 2 SHNi-TPR TPR_7 PF13176.1 ESA08620.1 - 0.005 16.5 4.2 0.46 10.4 0.1 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA08620.1 - 0.093 12.6 3.7 40 4.1 0.1 5.3 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat PPTA PF01239.17 ESA08620.1 - 0.18 11.2 3.6 3.4 7.1 0.0 4.6 5 0 0 5 5 5 0 Protein prenyltransferase alpha subunit repeat TPR_20 PF14561.1 ESA08620.1 - 0.51 10.4 3.4 0.93 9.6 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1797 PF08796.5 ESA08622.1 - 0.099 12.5 0.1 9 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) Thioredoxin_9 PF14595.1 ESA08624.1 - 0.13 11.7 0.0 0.37 10.3 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin NUC130_3NT PF08158.7 ESA08625.1 - 2e-20 72.7 0.2 2e-20 72.7 0.2 2.2 2 0 0 2 2 2 1 NUC130/3NT domain TFIID_90kDa PF04494.10 ESA08625.1 - 0.83 9.7 9.3 1.8 8.6 2.0 3.3 2 1 1 4 4 4 0 WD40 associated region in TFIID subunit Grp1_Fun34_YaaH PF01184.14 ESA08626.1 - 1.2e-56 191.4 16.3 1.3e-56 191.2 11.3 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF309 PF03745.9 ESA08626.1 - 0.0097 15.3 0.2 0.021 14.2 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF309) DUF373 PF04123.8 ESA08626.1 - 0.43 9.5 2.6 0.58 9.1 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) GCS PF03074.11 ESA08627.1 - 4e-177 588.8 10.2 6.8e-176 584.7 7.1 2.0 1 1 0 1 1 1 1 Glutamate-cysteine ligase S1 PF00575.18 ESA08627.1 - 0.045 13.8 0.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 S1 RNA binding domain Sel1 PF08238.7 ESA08628.1 - 5.3e-93 303.4 47.9 1.7e-11 44.3 0.4 11.4 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ESA08628.1 - 6.6e-07 29.3 26.6 4 8.1 0.1 10.0 11 0 0 11 11 11 4 Tetratricopeptide repeat MMtag PF10159.4 ESA08628.1 - 0.016 15.2 2.0 0.33 11.0 0.0 2.9 1 1 1 2 2 2 0 Kinase phosphorylation protein Papo_T_antigen PF02380.10 ESA08628.1 - 0.5 10.3 5.4 6.8 6.6 0.0 4.3 2 2 3 5 5 5 0 T-antigen specific domain BTB PF00651.26 ESA08631.1 - 4.2e-15 55.6 1.2 7.7e-15 54.8 0.8 1.4 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA08632.1 - 4e-08 33.3 0.2 5.5e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA08633.1 - 5.2e-18 65.0 0.8 1.2e-17 63.8 0.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA08633.1 - 3.5e-05 23.8 0.2 0.00011 22.3 0.0 1.7 2 0 0 2 2 2 1 SPRY domain DUF1366 PF07104.6 ESA08633.1 - 0.012 15.2 0.2 0.17 11.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) DivIC PF04977.10 ESA08634.1 - 0.006 16.0 2.8 0.011 15.2 1.9 1.4 1 0 0 1 1 1 1 Septum formation initiator FtsL PF04999.8 ESA08634.1 - 0.037 13.7 1.7 0.069 12.8 1.2 1.4 1 0 0 1 1 1 0 Cell division protein FtsL HALZ PF02183.13 ESA08634.1 - 0.19 11.4 5.6 0.23 11.1 3.0 1.7 1 1 1 2 2 2 0 Homeobox associated leucine zipper Uso1_p115_C PF04871.8 ESA08634.1 - 0.36 10.7 7.6 0.47 10.3 4.8 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF904 PF06005.7 ESA08634.1 - 0.37 11.1 7.6 0.69 10.2 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) CMV_1a PF12467.3 ESA08634.1 - 1.7 9.0 8.7 2.1 8.6 6.1 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family DUF972 PF06156.8 ESA08634.1 - 4.3 7.7 7.3 2.1 8.7 3.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) M PF02370.11 ESA08634.1 - 5.4 7.7 9.3 0.93 10.0 2.7 2.6 2 0 0 2 2 2 0 M protein repeat DUF4614 PF15391.1 ESA08637.1 - 0.078 12.7 5.2 0.083 12.6 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Pex16 PF08610.5 ESA08637.1 - 0.12 11.3 3.0 0.13 11.2 2.1 1.0 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) SR-25 PF10500.4 ESA08637.1 - 0.23 10.9 13.2 0.29 10.5 9.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pap_E4 PF02711.9 ESA08637.1 - 0.23 12.2 2.9 0.26 12.1 2.0 1.2 1 0 0 1 1 1 0 E4 protein MRI PF15325.1 ESA08637.1 - 0.44 11.5 3.4 0.56 11.1 2.3 1.2 1 0 0 1 1 1 0 Modulator of retrovirus infection Period_C PF12114.3 ESA08637.1 - 0.44 10.1 8.6 0.48 10.0 5.9 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF3633 PF12315.3 ESA08637.1 - 0.72 9.1 3.9 0.88 8.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) Macoilin PF09726.4 ESA08637.1 - 1.4 7.1 8.3 1.5 7.0 5.7 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF2217 PF10265.4 ESA08637.1 - 3.1 6.4 5.9 2.9 6.5 4.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) SSP160 PF06933.6 ESA08637.1 - 4.9 5.0 9.7 5.7 4.8 6.7 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RAP1 PF07218.6 ESA08637.1 - 8.4 4.3 9.3 7.8 4.4 6.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Ser_hydrolase PF06821.8 ESA08638.1 - 0.16 11.5 0.7 0.19 11.3 0.5 1.1 1 0 0 1 1 1 0 Serine hydrolase Ribosomal_S25 PF03297.10 ESA08638.1 - 0.29 11.1 2.6 0.36 10.8 1.8 1.1 1 0 0 1 1 1 0 S25 ribosomal protein TT_ORF1 PF02956.9 ESA08638.1 - 5.7 5.2 9.6 6.3 5.1 6.7 1.0 1 0 0 1 1 1 0 TT viral orf 1 Sel1 PF08238.7 ESA08639.1 - 6.1e-105 341.3 51.5 5.6e-11 42.7 0.5 12.8 12 1 0 12 12 12 12 Sel1 repeat MIT PF04212.13 ESA08639.1 - 7.6e-05 22.5 20.1 4.3 7.2 0.1 6.8 7 0 0 7 7 7 2 MIT (microtubule interacting and transport) domain Exonuc_VII_S PF02609.11 ESA08639.1 - 0.012 15.3 0.2 55 3.6 0.0 4.7 5 0 0 5 5 5 0 Exonuclease VII small subunit DUF2733 PF10813.3 ESA08639.1 - 0.022 14.2 3.1 23 4.6 0.0 5.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2733) CobT_C PF11775.3 ESA08639.1 - 0.21 10.9 2.0 11 5.3 0.0 3.5 4 0 0 4 4 4 0 Cobalamin biosynthesis protein CobT VWA domain VanY PF02557.12 ESA08639.1 - 1.2 8.9 7.2 6.7 6.5 0.0 4.1 3 2 1 5 5 5 0 D-alanyl-D-alanine carboxypeptidase ATP-synt_DE PF00401.15 ESA08639.1 - 2 8.3 5.2 1.3e+02 2.5 0.0 4.4 5 0 0 5 5 5 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain IQ-like PF15157.1 ESA08639.1 - 3.2 8.0 9.3 24 5.2 0.1 4.1 4 0 0 4 4 4 0 IQ-like Thioredoxin PF00085.15 ESA08640.1 - 1.4e-30 105.0 0.2 1.6e-30 104.8 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESA08640.1 - 5.3e-09 36.0 0.8 1.7e-06 28.0 0.1 2.5 1 1 2 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA08640.1 - 1.1e-07 32.0 0.4 7.9e-07 29.2 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 ESA08640.1 - 2.4e-06 27.4 0.0 3.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESA08640.1 - 4.9e-05 22.9 0.0 6.2e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 ESA08640.1 - 5.7e-05 22.7 0.2 0.00019 21.0 0.1 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESA08640.1 - 0.00025 20.6 0.2 0.0017 17.9 0.2 1.8 1 1 1 2 2 2 1 Redoxin DIM1 PF02966.11 ESA08640.1 - 0.00086 18.8 0.0 0.00097 18.6 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 DUF953 PF06110.6 ESA08640.1 - 0.0013 18.1 0.1 0.0091 15.4 0.1 2.0 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) TraF PF13728.1 ESA08640.1 - 0.0019 17.7 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.1 ESA08640.1 - 0.0019 17.9 0.0 0.0031 17.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredox_DsbH PF03190.10 ESA08640.1 - 0.01 15.5 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_6 PF13848.1 ESA08640.1 - 0.063 13.0 0.4 0.13 12.0 0.1 1.3 1 1 1 2 2 2 0 Thioredoxin-like domain SCO1-SenC PF02630.9 ESA08640.1 - 0.07 12.7 0.1 0.087 12.4 0.1 1.2 1 0 0 1 1 1 0 SCO1/SenC TrbC_Ftype PF09673.5 ESA08640.1 - 0.087 12.4 0.0 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein DDE_Tnp_1_7 PF13843.1 ESA08641.1 - 0.0074 15.3 0.1 0.027 13.5 0.0 2.0 2 1 0 2 2 2 1 Transposase IS4 TSKS PF15358.1 ESA08641.1 - 0.026 12.6 0.0 0.041 12.0 0.0 1.3 1 0 0 1 1 1 0 Testis-specific serine kinase substrate RabGAP-TBC PF00566.13 ESA08644.1 - 6.3e-23 81.3 1.1 1.8e-22 79.8 0.8 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IncA PF04156.9 ESA08644.1 - 7 6.1 24.3 6.2 6.3 4.1 3.3 3 1 0 3 3 3 0 IncA protein RAI1 PF08652.6 ESA08645.1 - 1.9e-24 85.2 0.0 4.7e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease Tenui_NS4 PF03300.8 ESA08648.1 - 0.061 12.3 0.0 0.072 12.1 0.0 1.2 1 0 0 1 1 1 0 Tenuivirus non-structural protein NS4 ATP_bind_3 PF01171.15 ESA08648.1 - 0.11 12.0 0.1 0.61 9.5 0.0 2.0 1 1 1 2 2 2 0 PP-loop family O-FucT PF10250.4 ESA08649.1 - 3.2e-08 33.0 3.3 1.1e-06 27.9 2.3 2.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peptidase_C26 PF07722.8 ESA08649.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase C26 Ras PF00071.17 ESA08651.1 - 1.3e-38 131.8 0.1 1.5e-38 131.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA08651.1 - 7.4e-16 58.7 0.0 8.4e-16 58.5 0.0 1.0 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA08651.1 - 1.7e-06 27.3 0.0 2e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA08651.1 - 0.0036 17.2 0.0 0.0043 17.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA08651.1 - 0.007 15.8 0.0 0.014 14.8 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESA08651.1 - 0.076 12.1 0.6 0.11 11.6 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 ESA08651.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytochrome-c551 PF10643.4 ESA08652.1 - 0.076 12.2 0.2 0.083 12.1 0.1 1.1 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 BTB PF00651.26 ESA08653.1 - 8.9e-09 35.3 0.2 9.4e-09 35.2 0.1 1.0 1 0 0 1 1 1 1 BTB/POZ domain RPE65 PF03055.10 ESA08653.1 - 0.051 12.1 0.0 0.051 12.1 0.0 1.0 1 0 0 1 1 1 0 Retinal pigment epithelial membrane protein DUF2251 PF10008.4 ESA08654.1 - 0.093 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) DUF1064 PF06356.6 ESA08655.1 - 0.11 12.5 0.1 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1064) Bromodomain PF00439.20 ESA08656.1 - 2e-19 69.2 1.4 2.3e-19 69.0 1.0 1.1 1 0 0 1 1 1 1 Bromodomain Spore_GerAC PF05504.6 ESA08656.1 - 0.011 15.5 0.1 0.011 15.5 0.1 1.1 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Pox_polyA_pol_N PF12630.2 ESA08656.1 - 0.058 13.4 1.0 0.065 13.3 0.7 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain DUF3928 PF13065.1 ESA08656.1 - 0.077 13.2 0.4 0.096 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3928) His_binding PF02098.11 ESA08656.1 - 0.14 12.0 1.0 2 8.2 0.2 2.0 1 1 1 2 2 2 0 Tick histamine binding protein DUF2618 PF10940.3 ESA08658.1 - 0.14 11.9 0.4 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) DUF1146 PF06612.6 ESA08661.1 - 0.021 14.7 0.8 0.035 13.9 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1146) NPV_P10 PF05531.7 ESA08662.1 - 0.0052 17.0 3.1 0.15 12.3 0.1 2.6 3 0 0 3 3 3 2 Nucleopolyhedrovirus P10 protein ING PF12998.2 ESA08662.1 - 0.01 16.1 1.4 0.018 15.2 0.3 2.0 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Baculo_PEP_C PF04513.7 ESA08662.1 - 1.5 8.6 6.0 22 4.8 4.2 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.15 ESA08662.1 - 5.5 6.8 7.8 4.1 7.2 0.3 3.2 3 1 0 3 3 3 0 Prefoldin subunit CITED PF04487.7 ESA08665.1 - 0.48 10.6 22.3 0.14 12.3 13.4 1.5 1 1 1 2 2 2 0 CITED HECT PF00632.20 ESA08673.1 - 6.5e-93 311.3 0.0 8.8e-93 310.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.22 ESA08674.1 - 0.0055 16.2 1.1 0.011 15.3 0.1 2.1 2 0 0 2 2 2 1 IQ calmodulin-binding motif LRR_6 PF13516.1 ESA08675.1 - 0.071 13.2 6.9 22 5.4 0.0 5.6 6 1 0 6 6 6 0 Leucine Rich repeat F-box PF00646.28 ESA08675.1 - 0.27 10.9 4.2 1.1 8.9 0.1 3.0 3 0 0 3 3 3 0 F-box domain HPD PF05044.7 ESA08676.1 - 0.018 14.7 0.6 0.019 14.6 0.4 1.1 1 0 0 1 1 1 0 Homeo-prospero domain Flavodoxin_4 PF12682.2 ESA08676.1 - 0.13 11.6 0.2 0.14 11.5 0.1 1.0 1 0 0 1 1 1 0 Flavodoxin ubiquitin PF00240.18 ESA08677.1 - 2.5e-16 58.7 0.1 3.4e-16 58.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 ESA08677.1 - 1.9e-07 31.2 0.2 2.4e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 ESA08677.1 - 2e-06 27.3 0.1 2.5e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ESA08677.1 - 6.4e-05 23.0 0.0 7.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA08677.1 - 0.008 16.0 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UN_NPL4 PF11543.3 ESA08677.1 - 0.096 12.9 0.2 0.12 12.6 0.1 1.1 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 YwqJ-deaminase PF14431.1 ESA08678.1 - 0.46 10.3 2.1 9.3 6.1 0.7 2.3 2 0 0 2 2 2 0 YwqJ-like deaminase DUF1410 PF07198.6 ESA08679.1 - 0.0013 18.9 0.3 0.0019 18.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1410) DUF2874 PF11396.3 ESA08679.1 - 0.2 11.6 0.9 0.43 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) TLD PF07534.11 ESA08680.1 - 8.9e-13 48.4 1.2 2.9e-11 43.5 0.2 2.2 2 0 0 2 2 2 2 TLD BACK PF07707.10 ESA08680.1 - 0.0036 17.1 0.2 0.019 14.7 0.0 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch DDE_3 PF13358.1 ESA08681.1 - 1.5e-05 24.7 0.6 2.2e-05 24.2 0.2 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease NYD-SP28 PF14772.1 ESA08681.1 - 0.067 13.2 0.3 1.2 9.2 0.1 2.0 1 1 1 2 2 2 0 Sperm tail Unstab_antitox PF09720.5 ESA08681.1 - 0.23 11.1 1.2 0.54 9.9 0.6 1.9 1 1 0 1 1 1 0 Putative addiction module component SieB PF14163.1 ESA08682.1 - 0.0013 18.2 0.7 0.0013 18.2 0.5 2.9 3 0 0 3 3 3 1 Superinfection exclusion protein B zf-CW PF07496.10 ESA08683.1 - 0.0014 18.3 0.0 0.005 16.5 0.0 2.1 1 0 0 1 1 1 1 CW-type Zinc Finger DUF3684 PF12449.3 ESA08684.1 - 8.4e-165 550.1 10.0 3.1e-132 442.3 2.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) DUF261 PF03196.8 ESA08684.1 - 0.011 15.6 5.2 1.4 8.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function, DUF261 SpoIIID PF12116.3 ESA08684.1 - 0.014 15.3 0.2 2.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Stage III sporulation protein D DUF3024 PF11225.3 ESA08684.1 - 0.06 13.2 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Na_H_Exchanger PF00999.16 ESA08685.1 - 1.3e-66 224.7 50.8 1.7e-66 224.3 35.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family BIV_Env PF05858.7 ESA08685.1 - 0.085 10.8 4.3 0.16 9.8 3.0 1.5 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) RED_N PF07808.8 ESA08686.1 - 0.1 11.7 4.3 0.12 11.6 3.0 1.0 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2663 PF10864.3 ESA08687.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) DUF1163 PF06651.6 ESA08688.1 - 0.099 12.2 0.1 6.2 6.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) DUF3090 PF11290.3 ESA08690.1 - 0.025 14.0 0.2 0.026 13.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) DRMBL PF07522.9 ESA08693.1 - 3.5e-32 110.7 0.5 1.1e-31 109.1 0.3 1.9 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 ESA08693.1 - 1e-09 38.2 0.2 4.7e-09 36.0 0.2 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESA08693.1 - 0.081 12.5 0.9 0.28 10.7 0.5 1.9 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Ank_2 PF12796.2 ESA08695.1 - 7.5e-45 151.1 0.2 1.3e-20 73.5 0.0 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESA08695.1 - 2.4e-30 102.7 0.1 3.3e-12 45.5 0.0 4.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 ESA08695.1 - 1.8e-22 79.2 0.1 3.1e-11 43.4 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA08695.1 - 3.3e-20 70.1 0.1 1.6e-08 33.9 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 ESA08695.1 - 3.1e-19 68.5 0.1 8.6e-09 35.3 0.0 4.1 1 1 3 4 4 4 3 Ankyrin repeats (many copies) DUF249 PF03158.8 ESA08695.1 - 0.014 14.9 0.0 0.036 13.5 0.0 1.8 2 0 0 2 2 2 0 Multigene family 530 protein HSP70 PF00012.15 ESA08696.1 - 0.025 12.5 0.0 1.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Hsp70 protein Sel1 PF08238.7 ESA08700.1 - 5.3e-65 214.4 8.9 2e-10 40.9 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_17 PF13431.1 ESA08700.1 - 1.8e-05 24.5 1.5 35 4.9 0.0 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat NifW PF03206.9 ESA08700.1 - 0.00018 21.6 0.1 16 5.6 0.0 4.3 3 2 1 4 4 4 2 Nitrogen fixation protein NifW TPR_5 PF12688.2 ESA08700.1 - 0.04 13.9 2.8 41 4.2 0.0 5.1 4 2 1 6 6 6 0 Tetratrico peptide repeat B12-binding_2 PF02607.12 ESA08700.1 - 0.069 13.1 0.0 5.2 7.1 0.0 3.2 3 1 1 4 4 4 0 B12 binding domain DUF2435 PF10363.4 ESA08702.1 - 0.031 14.1 1.4 0.1 12.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2435) Pkinase_Tyr PF07714.12 ESA08704.1 - 9.3e-27 93.7 0.0 1.3e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08704.1 - 1.1e-25 90.2 0.0 1.6e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RRM_6 PF14259.1 ESA08705.1 - 0.012 15.5 0.2 2.8 8.0 0.0 2.9 3 0 0 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 ESA08705.1 - 0.051 13.5 0.0 0.16 11.9 0.0 1.9 1 0 0 1 1 1 0 RNA binding domain UpxZ PF06603.6 ESA08705.1 - 0.055 13.5 0.1 0.17 11.9 0.0 1.9 1 1 0 1 1 1 0 UpxZ family of transcription anti-terminator antagonists PPR_2 PF13041.1 ESA08706.1 - 4.9e-08 32.8 3.8 0.0028 17.6 0.0 4.8 6 1 0 6 6 6 3 PPR repeat family PPR PF01535.15 ESA08706.1 - 1.1e-06 28.2 7.8 0.13 12.2 0.0 5.8 5 0 0 5 5 5 2 PPR repeat DUF1600 PF07667.6 ESA08706.1 - 0.0039 17.2 0.9 0.0039 17.2 0.7 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1600) PPR_1 PF12854.2 ESA08706.1 - 0.02 14.3 1.2 0.15 11.6 0.1 2.8 3 0 0 3 3 3 0 PPR repeat PPR_3 PF13812.1 ESA08706.1 - 0.03 14.5 0.0 0.88 10.0 0.0 2.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain CLTH PF10607.4 ESA08706.1 - 0.23 11.1 4.5 0.55 9.9 3.1 2.1 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain APP_Cu_bd PF12924.2 ESA08708.1 - 0.13 12.7 0.9 0.26 11.8 0.1 1.9 2 0 0 2 2 2 0 Copper-binding of amyloid precursor, CuBD WD40 PF00400.27 ESA08709.1 - 2.2e-40 135.0 13.6 5.7e-09 35.5 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat OpuAC PF04069.7 ESA08709.1 - 0.024 14.0 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system YmzC PF14157.1 ESA08709.1 - 0.091 12.5 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 YmzC-like protein ubiquitin PF00240.18 ESA08710.1 - 0.03 13.7 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family DNA_pol_B PF00136.16 ESA08711.1 - 1.4e-120 403.2 1.5 2e-120 402.7 1.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESA08711.1 - 6.2e-61 206.0 1.4 2.9e-49 167.6 0.2 2.6 2 1 1 3 3 3 2 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.8 ESA08711.1 - 0.0013 17.4 5.8 0.029 13.0 1.6 2.9 2 1 0 2 2 2 2 DNA polymerase type B, organellar and viral DNA_pol_A_exo1 PF01612.15 ESA08711.1 - 0.0042 16.5 0.8 0.012 15.1 0.0 2.1 2 0 0 2 2 2 1 3'-5' exonuclease RNase_H_2 PF13482.1 ESA08711.1 - 0.0086 15.9 0.6 0.038 13.8 0.4 2.3 1 1 0 1 1 1 1 RNase_H superfamily Pkinase PF00069.20 ESA08713.1 - 3.1e-23 82.2 0.7 4.1e-23 81.8 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08713.1 - 5.9e-21 74.7 0.0 7.3e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_M54 PF07998.6 ESA08713.1 - 0.076 12.7 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Peptidase family M54 Med11 PF10280.4 ESA08714.1 - 0.069 13.2 0.2 0.084 12.9 0.2 1.1 1 0 0 1 1 1 0 Mediator complex protein Sas10 PF09368.5 ESA08714.1 - 0.13 12.4 4.5 0.16 12.1 3.0 1.4 1 1 0 1 1 1 0 Sas10 C-terminal domain Pox_H7 PF04787.7 ESA08714.1 - 0.15 11.8 1.9 0.17 11.6 1.3 1.2 1 0 0 1 1 1 0 Late protein H7 Sel1 PF08238.7 ESA08717.1 - 1.7e-13 50.6 8.7 6e-08 33.0 0.4 3.1 4 0 0 4 4 4 2 Sel1 repeat TPR_6 PF13174.1 ESA08717.1 - 0.00045 20.4 3.4 0.93 10.0 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA08717.1 - 0.022 15.4 0.1 0.6 10.8 0.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA08717.1 - 0.22 11.8 0.9 30 5.0 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08717.1 - 0.39 10.4 5.7 0.18 11.4 1.6 2.3 2 1 0 2 2 2 0 TPR repeat TPR_1 PF00515.23 ESA08717.1 - 0.5 10.0 5.3 2.4 7.9 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA08717.1 - 7.3 6.6 8.1 41 4.2 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF758 PF05527.6 ESA08719.1 - 0.013 15.1 3.2 0.19 11.3 2.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF758) DUF2785 PF10978.3 ESA08719.1 - 0.023 14.1 0.1 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) Avl9 PF09794.4 ESA08719.1 - 0.056 11.9 0.5 0.074 11.5 0.4 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Pkinase_Tyr PF07714.12 ESA08720.1 - 2.9e-34 118.3 0.0 3.4e-34 118.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08720.1 - 2.1e-26 92.6 0.0 2.7e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1542 PF07564.6 ESA08722.1 - 0.068 13.1 0.5 0.11 12.5 0.0 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) zf-DNL PF05180.7 ESA08724.1 - 0.011 15.4 0.1 11 5.8 0.0 3.3 2 0 0 2 2 2 0 DNL zinc finger PRESAN PF09687.5 ESA08725.1 - 0.0073 16.3 2.5 0.0087 16.1 1.7 1.2 1 0 0 1 1 1 1 Plasmodium RESA N-terminal ANTH PF07651.11 ESA08725.1 - 0.053 12.2 0.1 0.053 12.2 0.1 1.1 1 0 0 1 1 1 0 ANTH domain Seryl_tRNA_N PF02403.17 ESA08726.1 - 0.0031 17.4 1.8 0.051 13.5 0.1 2.2 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain BRE1 PF08647.6 ESA08726.1 - 0.016 15.1 1.8 0.084 12.8 0.3 2.1 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF904 PF06005.7 ESA08726.1 - 0.077 13.3 0.5 0.97 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Orthopox_A5L PF06193.6 ESA08726.1 - 0.24 11.3 5.3 0.2 11.5 0.8 2.0 2 0 0 2 2 2 0 Orthopoxvirus A5L protein-like DUF4107 PF13389.1 ESA08726.1 - 0.73 9.5 2.5 16 5.1 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4107) 7TMR-DISM_7TM PF07695.6 ESA08727.1 - 0.0006 19.5 7.8 0.0006 19.5 5.4 2.1 2 0 0 2 2 2 1 7TM diverse intracellular signalling ProRS-C_2 PF09181.5 ESA08727.1 - 0.005 16.7 0.0 0.02 14.8 0.0 2.0 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal BACK PF07707.10 ESA08728.1 - 4.8e-08 32.7 1.1 7.1e-07 29.0 0.2 2.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch Med6 PF04934.9 ESA08729.1 - 0.025 14.1 1.3 0.038 13.5 0.9 1.3 1 0 0 1 1 1 0 MED6 mediator sub complex component bZIP_C PF12498.3 ESA08729.1 - 3.4 8.9 7.5 4.1 8.6 4.9 1.3 1 1 0 1 1 1 0 Basic leucine-zipper C terminal MFS_1 PF07690.11 ESA08730.1 - 1e-34 119.8 27.8 1e-34 119.8 19.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CK2S PF15011.1 ESA08732.1 - 0.057 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Casein Kinase 2 substrate Rootletin PF15035.1 ESA08732.1 - 0.073 13.0 8.5 0.18 11.7 5.9 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Carbpep_Y_N PF05388.6 ESA08732.1 - 0.075 13.1 2.8 0.093 12.8 0.5 2.2 2 0 0 2 2 2 0 Carboxypeptidase Y pro-peptide Methyltransf_11 PF08241.7 ESA08733.1 - 2.4e-16 60.0 0.0 1.5e-14 54.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA08733.1 - 5.9e-12 45.6 0.0 9e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08733.1 - 2e-10 40.9 0.0 4.5e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08733.1 - 1.8e-09 37.3 0.0 5.4e-09 35.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA08733.1 - 2.8e-08 34.3 0.0 1.5e-07 31.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08733.1 - 3e-07 30.8 0.0 7.5e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA08733.1 - 4.9e-07 29.5 0.0 8.2e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase Ubie_methyltran PF01209.13 ESA08733.1 - 9.5e-06 24.8 0.0 2.5e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ESA08733.1 - 4e-05 23.0 0.0 6.7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ESA08733.1 - 6.4e-05 22.0 0.0 0.00031 19.8 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA08733.1 - 0.0023 17.9 0.0 0.0056 16.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESA08733.1 - 0.0024 17.1 0.0 0.0039 16.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase FtsJ PF01728.14 ESA08733.1 - 0.0091 15.9 0.0 0.017 15.1 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase TehB PF03848.9 ESA08733.1 - 0.025 13.7 0.0 0.068 12.3 0.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.12 ESA08733.1 - 0.075 11.9 0.0 0.24 10.3 0.0 1.7 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Amidase_2 PF01510.20 ESA08737.1 - 6.7e-16 58.5 0.0 1e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Methyltransf_31 PF13847.1 ESA08738.1 - 9.8e-20 70.6 0.1 1.4e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA08738.1 - 3e-17 63.2 0.0 4.5e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA08738.1 - 1.5e-09 37.7 0.0 5.4e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08738.1 - 4.4e-08 33.5 0.0 1e-07 32.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08738.1 - 5.5e-08 33.1 0.0 1.8e-07 31.5 0.0 1.9 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA08738.1 - 3.7e-07 30.1 0.0 5.4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESA08738.1 - 1.2e-06 27.8 0.0 2.2e-06 26.9 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.9 ESA08738.1 - 1.5e-06 27.5 0.2 2.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 ESA08738.1 - 1.8e-06 27.1 0.0 2.5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 ESA08738.1 - 1.9e-06 27.3 0.0 3.1e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESA08738.1 - 4.5e-06 26.9 0.0 7.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 ESA08738.1 - 5.2e-05 22.0 0.1 5.3e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.1 ESA08738.1 - 0.0002 21.0 0.0 0.0003 20.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.11 ESA08738.1 - 0.00088 18.2 0.4 0.0015 17.4 0.1 1.5 2 0 0 2 2 2 1 mRNA capping enzyme PrmA PF06325.8 ESA08738.1 - 0.0013 17.9 0.1 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_20 PF12147.3 ESA08738.1 - 0.0024 16.7 0.0 0.0033 16.3 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_9 PF08003.6 ESA08738.1 - 0.0026 16.5 0.0 0.0035 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.6 ESA08738.1 - 0.0042 16.4 0.0 0.0059 16.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.7 ESA08738.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.8 ESA08738.1 - 0.015 15.4 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DOT1 PF08123.8 ESA08738.1 - 0.015 14.5 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Cons_hypoth95 PF03602.10 ESA08738.1 - 0.054 12.8 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 ESA08738.1 - 0.058 12.9 0.1 0.081 12.4 0.1 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase AviRa PF11599.3 ESA08738.1 - 0.088 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa EST1_DNA_bind PF10373.4 ESA08739.1 - 0.06 12.5 1.3 0.076 12.2 0.8 1.4 1 1 0 1 1 1 0 Est1 DNA/RNA binding domain KdpC PF02669.10 ESA08739.1 - 0.073 12.7 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Pkinase PF00069.20 ESA08741.1 - 4.7e-25 88.2 0.1 6e-12 45.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08741.1 - 1.3e-19 70.2 0.0 1e-09 37.8 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESA08741.1 - 0.021 13.7 0.0 4.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like BACK PF07707.10 ESA08742.1 - 2.1e-07 30.7 3.3 6.9e-06 25.8 0.6 2.9 1 1 2 3 3 3 3 BTB And C-terminal Kelch Sel1 PF08238.7 ESA08743.1 - 5.7e-69 227.0 4.9 1.2e-09 38.4 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA08743.1 - 4e-09 36.3 7.7 0.18 12.3 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA08743.1 - 2.2e-08 33.6 3.9 1.1 9.6 0.0 6.5 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08743.1 - 0.00053 19.8 13.2 3.5 7.6 0.4 5.5 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08743.1 - 0.022 14.3 22.5 0.71 9.5 0.2 5.5 1 1 5 6 6 6 0 TPR repeat TPR_19 PF14559.1 ESA08743.1 - 0.034 14.4 0.1 14 6.1 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA08743.1 - 0.037 14.7 0.2 37 5.1 0.0 3.8 2 1 3 5 5 5 0 Tetratricopeptide repeat Chordopox_A13L PF05961.6 ESA08743.1 - 0.067 13.1 5.8 43 4.1 0.0 5.4 5 1 1 6 6 6 0 Chordopoxvirus A13L protein Apc3 PF12895.2 ESA08743.1 - 0.3 11.2 13.0 5.3 7.2 0.3 4.4 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 ESA08745.1 - 4.3e-09 35.8 1.1 8.6e-09 34.9 0.8 1.5 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 ESA08745.1 - 0.037 13.9 0.6 5.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ACCA PF03255.9 ESA08746.1 - 0.0044 16.5 0.1 0.95 9.0 0.0 2.5 2 0 0 2 2 2 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit zf-ribbon_3 PF13248.1 ESA08746.1 - 0.031 13.4 0.1 9.2 5.6 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Pkinase_Tyr PF07714.12 ESA08746.1 - 0.034 13.2 0.0 0.063 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase ADK_lid PF05191.9 ESA08746.1 - 0.052 13.2 0.5 12 5.6 0.0 2.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF4047 PF13256.1 ESA08746.1 - 0.26 11.2 3.2 1.2 9.1 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DZR PF12773.2 ESA08746.1 - 0.38 10.6 10.6 0.6 9.9 0.4 2.7 3 0 0 3 3 3 0 Double zinc ribbon DUF1247 PF06851.6 ESA08746.1 - 0.74 9.4 10.5 2.1 8.0 2.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) zinc_ribbon_2 PF13240.1 ESA08746.1 - 0.84 9.1 8.7 4 7.0 0.6 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-dskA_traR PF01258.12 ESA08746.1 - 4.3 7.1 12.7 12 5.7 0.4 3.0 2 1 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger BTB PF00651.26 ESA08749.1 - 7.8e-07 29.0 0.0 9.8e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Ran_BP1 PF00638.13 ESA08752.1 - 0.011 15.7 0.3 0.033 14.2 0.2 1.8 1 0 0 1 1 1 0 RanBP1 domain DUF1751 PF08551.5 ESA08754.1 - 0.089 13.1 1.0 0.11 12.8 0.7 1.4 1 1 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) BTB PF00651.26 ESA08758.1 - 1.4e-15 57.2 0.0 2.6e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA08758.1 - 8.2e-06 25.8 0.0 2.8e-05 24.1 0.0 1.9 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA08758.1 - 1.8e-05 24.4 3.6 5.6e-05 22.9 0.5 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch CBM_5_12_2 PF14600.1 ESA08758.1 - 0.13 11.8 0.1 0.38 10.4 0.0 1.8 1 0 0 1 1 1 0 Cellulose-binding domain ubiquitin PF00240.18 ESA08759.1 - 0.071 12.5 0.9 0.18 11.2 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin family BTB PF00651.26 ESA08761.1 - 2.3e-13 50.1 0.1 5.1e-13 48.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA08761.1 - 6.3e-11 42.0 7.8 2.8e-08 33.5 1.1 3.8 3 1 1 4 4 4 2 BTB And C-terminal Kelch Bcl-2 PF00452.14 ESA08761.1 - 0.089 12.9 0.7 0.35 11.0 0.0 2.4 2 1 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family DUF2874 PF11396.3 ESA08762.1 - 0.016 15.1 0.5 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) zf-B_box PF00643.19 ESA08762.1 - 0.17 11.8 4.9 0.31 10.9 3.4 1.4 1 0 0 1 1 1 0 B-box zinc finger HSP90 PF00183.13 ESA08764.1 - 2.9e-261 867.4 38.4 2.9e-261 867.4 26.6 1.5 2 0 0 2 2 2 1 Hsp90 protein HATPase_c_3 PF13589.1 ESA08764.1 - 1.1e-10 41.3 0.1 1.1e-10 41.3 0.0 2.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA08764.1 - 4.5e-10 39.2 0.0 8.1e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF399 PF04187.8 ESA08764.1 - 0.052 13.0 0.9 0.28 10.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF399 Tom37_C PF11801.3 ESA08764.1 - 2.2 8.1 12.3 15 5.4 6.4 2.5 2 0 0 2 2 2 0 Tom37 C-terminal domain DUF1510 PF07423.6 ESA08764.1 - 4.3 6.6 27.7 0.17 11.1 13.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) BCS1_N PF08740.6 ESA08765.1 - 1.8e-08 34.2 0.1 0.055 13.0 0.0 3.7 4 0 0 4 4 4 2 BCS1 N terminal Pkinase_Tyr PF07714.12 ESA08765.1 - 3.4e-05 23.0 0.0 0.35 9.8 0.0 3.7 4 0 0 4 4 4 2 Protein tyrosine kinase DZR PF12773.2 ESA08765.1 - 0.0019 18.0 12.7 0.44 10.4 0.9 3.4 3 0 0 3 3 3 3 Double zinc ribbon NOB1_Zn_bind PF08772.6 ESA08765.1 - 0.074 12.8 9.8 0.5 10.2 0.2 3.5 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like AP4E_app_platf PF14807.1 ESA08765.1 - 0.11 12.7 0.4 7 6.9 0.0 3.4 4 0 0 4 4 4 0 Adaptin AP4 complex epsilon appendage platform MarR PF01047.17 ESA08765.1 - 0.13 11.9 0.2 35 4.2 0.0 3.3 3 0 0 3 3 3 0 MarR family Mvb12 PF09452.5 ESA08765.1 - 0.88 9.7 5.8 49 4.2 0.1 4.1 3 1 1 4 4 4 0 ESCRT-I subunit Mvb12 zf-ribbon_3 PF13248.1 ESA08765.1 - 1.1 8.6 9.7 1.3 8.3 0.7 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA08765.1 - 7 6.2 9.1 2 7.9 0.3 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Glycoprotein_B PF00606.13 ESA08766.1 - 0.042 11.8 10.1 0.018 13.1 5.4 1.5 1 1 1 2 2 2 0 Herpesvirus Glycoprotein B DUF267 PF03268.9 ESA08766.1 - 0.057 12.2 0.1 0.12 11.2 0.1 1.4 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF267 FAM91_C PF14648.1 ESA08766.1 - 0.34 9.6 5.1 0.64 8.7 2.3 1.8 1 1 1 2 2 2 0 FAM91 C-terminus EndoU_bacteria PF14436.1 ESA08766.1 - 0.78 9.5 7.1 0.54 10.0 3.7 1.7 1 1 0 1 1 1 0 Bacterial EndoU nuclease YgbB PF02542.11 ESA08766.1 - 1.6 8.5 8.2 0.97 9.2 1.1 2.3 1 1 1 2 2 2 0 YgbB family TLD PF07534.11 ESA08769.1 - 0.0012 18.8 0.3 0.0075 16.2 0.0 2.0 1 1 1 2 2 2 1 TLD CTP_transf_1 PF01148.15 ESA08769.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family TLD PF07534.11 ESA08770.1 - 4e-07 30.1 1.7 9.1e-07 28.9 1.2 1.6 1 1 0 1 1 1 1 TLD adh_short PF00106.20 ESA08771.1 - 5.7e-14 52.3 0.0 7.9e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA08771.1 - 4.7e-09 36.3 0.0 6.1e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA08771.1 - 4.9e-06 26.3 0.1 3.9e-05 23.3 0.1 2.0 1 1 0 1 1 1 1 KR domain PEGA PF08308.6 ESA08773.1 - 0.022 14.5 0.1 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 PEGA domain Methyltransf_11 PF08241.7 ESA08774.1 - 4.6e-19 68.7 0.0 7.8e-19 67.9 0.0 1.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA08774.1 - 4.7e-17 62.1 0.0 5.4e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08774.1 - 9.9e-14 51.5 0.0 1.7e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08774.1 - 2.3e-11 43.5 0.0 4.8e-11 42.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08774.1 - 1.1e-10 41.8 0.0 1.7e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA08774.1 - 1.3e-10 40.7 0.0 2.5e-10 39.8 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA08774.1 - 5.5e-09 36.5 0.0 2.3e-08 34.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA08774.1 - 1.6e-06 28.1 0.0 3.1e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA08774.1 - 4.1e-05 23.0 0.0 6.4e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.15 ESA08774.1 - 0.0003 19.9 0.0 0.00042 19.4 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 ESA08774.1 - 0.00036 19.6 0.0 0.00054 19.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 ESA08774.1 - 0.0019 17.5 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.10 ESA08774.1 - 0.0036 16.9 0.0 0.0047 16.5 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase TPMT PF05724.6 ESA08774.1 - 0.0043 16.5 0.2 0.09 12.2 0.1 2.0 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) FtsJ PF01728.14 ESA08774.1 - 0.0085 16.1 0.0 0.0091 15.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.14 ESA08774.1 - 0.04 13.4 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 ESA08774.1 - 0.097 11.8 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB PrmA PF06325.8 ESA08774.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ubiquitin PF00240.18 ESA08775.1 - 3.3e-43 144.9 16.6 2.6e-14 52.3 0.0 4.7 5 0 0 5 5 5 4 Ubiquitin family Rad60-SLD PF11976.3 ESA08775.1 - 1.1e-31 108.2 15.4 2.9e-10 39.6 0.5 4.4 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like ZZ PF00569.12 ESA08775.1 - 7e-09 35.0 6.3 1.5e-08 34.0 4.4 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Ubiquitin_2 PF14560.1 ESA08775.1 - 0.00049 20.2 5.6 0.36 11.1 0.3 3.5 3 0 0 3 3 3 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA08775.1 - 0.0011 18.8 1.9 6.6 6.6 0.0 4.6 3 1 1 4 4 4 1 Ubiquitin-2 like Rad60 SUMO-like DUF1122 PF06557.6 ESA08775.1 - 0.014 14.5 0.1 1.5 7.9 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1122) BBS2_Mid PF14783.1 ESA08775.1 - 0.06 13.1 1.6 0.75 9.6 0.3 2.8 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PI3K_p85B PF02192.11 ESA08775.1 - 0.14 11.5 3.3 4.3 6.8 0.0 3.9 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain C1_3 PF07649.7 ESA08775.1 - 0.89 9.6 10.7 0.28 11.2 5.1 2.0 2 0 0 2 2 2 0 C1-like domain TUG-UBL1 PF11470.3 ESA08775.1 - 2.3 8.2 4.7 21 5.1 0.1 3.4 3 0 0 3 3 3 0 GLUT4 regulating protein TUG Sad1_UNC PF07738.8 ESA08777.1 - 1.1e-29 102.9 0.0 4.6e-15 55.5 0.0 2.4 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal GATase_2 PF00310.16 ESA08779.1 - 0.058 12.0 0.0 0.06 12.0 0.0 1.0 1 0 0 1 1 1 0 Glutamine amidotransferases class-II LRR_4 PF12799.2 ESA08780.1 - 3.4e-34 115.8 45.6 2.7e-08 33.2 0.3 9.6 6 3 2 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA08780.1 - 2.1e-29 101.0 43.3 2.7e-10 39.8 0.8 7.9 6 2 2 8 8 8 7 Leucine rich repeat LRR_1 PF00560.28 ESA08780.1 - 3.1e-10 38.6 35.4 0.4 10.8 0.2 12.9 12 1 1 13 13 13 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA08780.1 - 7.3e-08 31.3 28.6 0.98 9.9 0.0 12.7 13 0 0 13 13 13 2 Leucine rich repeat LRR_9 PF14580.1 ESA08780.1 - 2e-06 27.5 12.8 0.068 12.7 0.1 4.3 3 1 0 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.1 ESA08780.1 - 0.0003 20.5 33.6 0.53 10.5 0.1 10.9 11 2 2 13 13 13 2 Leucine Rich repeat DUF4106 PF13388.1 ESA08781.1 - 0.069 12.0 2.6 0.084 11.8 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Methyltransf_26 PF13659.1 ESA08782.1 - 6.2e-09 35.9 0.0 9.7e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08782.1 - 1e-05 25.1 0.1 1.8e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA08782.1 - 2.1e-05 23.9 0.0 0.00093 18.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain N6_Mtase PF02384.11 ESA08782.1 - 4.1e-05 22.8 0.8 7.4e-05 21.9 0.1 1.6 2 0 0 2 2 2 1 N-6 DNA Methylase NDK PF00334.14 ESA08782.1 - 0.0055 16.4 0.0 0.013 15.2 0.0 1.7 1 1 0 1 1 1 1 Nucleoside diphosphate kinase Methyltransf_18 PF12847.2 ESA08782.1 - 0.006 17.1 0.0 0.01 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08782.1 - 0.021 15.2 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08782.1 - 0.028 14.9 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08782.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain UvrC_HhH_N PF08459.6 ESA08782.1 - 0.12 11.8 0.0 0.4 10.1 0.0 1.8 2 0 0 2 2 2 0 UvrC Helix-hairpin-helix N-terminal Methyltransf_26 PF13659.1 ESA08783.1 - 8.3e-11 41.9 0.0 1.3e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA08783.1 - 5.2e-07 29.2 0.0 8.3e-07 28.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 ESA08783.1 - 0.00011 21.8 0.0 0.00017 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 ESA08783.1 - 0.0029 17.0 0.2 0.0068 15.8 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_24 PF13578.1 ESA08783.1 - 0.037 14.8 0.0 0.068 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.17 ESA08784.1 - 3.3e-12 45.8 0.0 3.8e-12 45.6 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA08784.1 - 1.1e-09 38.1 0.0 1.2e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA08784.1 - 0.074 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_binding_2 PF00890.19 ESA08785.1 - 1.4e-06 27.4 0.2 2.1e-06 26.8 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 ESA08785.1 - 3.9e-05 22.9 0.2 5.1e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESA08785.1 - 0.00031 20.6 0.1 0.00035 20.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA08785.1 - 0.00038 20.4 0.5 0.0009 19.2 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 ESA08785.1 - 0.00043 18.8 0.1 0.0006 18.4 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.19 ESA08785.1 - 0.0019 17.1 1.7 0.0022 16.9 0.8 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 ESA08785.1 - 0.0019 17.2 0.0 0.0027 16.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.17 ESA08785.1 - 0.0023 16.8 0.0 0.0029 16.5 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GDI PF00996.13 ESA08785.1 - 0.0029 15.9 0.0 0.0034 15.7 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor GMC_oxred_N PF00732.14 ESA08785.1 - 0.0058 15.8 0.0 0.0068 15.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ESA08785.1 - 0.01 14.7 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.22 ESA08785.1 - 0.017 15.4 0.0 0.025 14.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESA08785.1 - 0.053 12.6 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.9 ESA08785.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_synthase PF02540.12 ESA08786.1 - 0.03 13.2 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 NAD synthase Ssu72 PF04722.8 ESA08788.1 - 2.8e-85 284.5 0.0 3.4e-85 284.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein LMWPc PF01451.16 ESA08788.1 - 0.028 14.7 0.5 2.7 8.3 0.1 2.3 1 1 1 2 2 2 0 Low molecular weight phosphotyrosine protein phosphatase Abhydrolase_5 PF12695.2 ESA08789.1 - 5.3e-18 65.1 0.0 7.7e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA08789.1 - 3.9e-14 53.0 0.0 2.5e-12 47.1 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA08789.1 - 2.8e-08 33.4 0.0 0.00089 18.7 0.0 2.9 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DLH PF01738.13 ESA08789.1 - 9.3e-06 25.0 0.0 6.6e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 ESA08789.1 - 3.6e-05 23.3 0.0 7.3e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF818 PF05677.7 ESA08789.1 - 0.00012 20.9 0.0 0.00014 20.6 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_1 PF00561.15 ESA08789.1 - 0.00062 19.3 0.0 0.0031 17.1 0.0 1.8 1 1 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.7 ESA08789.1 - 0.0011 17.5 0.0 0.0026 16.3 0.0 1.6 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.6 ESA08789.1 - 0.012 15.2 0.0 0.058 13.0 0.0 1.9 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal PAF-AH_p_II PF03403.8 ESA08789.1 - 0.091 11.0 0.0 0.27 9.4 0.0 1.6 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II PGAP1 PF07819.8 ESA08789.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_3 PF07859.8 ESA08789.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold Aldo_ket_red PF00248.16 ESA08790.1 - 1.2e-47 162.1 0.0 1.4e-47 161.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pox_RNA_pol PF03293.9 ESA08791.1 - 0.023 14.2 1.4 1.4 8.4 0.1 2.3 1 1 1 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit AF-4 PF05110.8 ESA08791.1 - 9.8 3.8 17.2 11 3.6 11.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF950 PF06106.6 ESA08792.1 - 0.046 13.8 0.2 0.05 13.6 0.1 1.1 1 0 0 1 1 1 0 Staphylococcus protein of unknown function (DUF950) RNA_pol_3_Rpc31 PF11705.3 ESA08793.1 - 2e-24 86.8 16.1 2.4e-24 86.5 11.1 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Nitrophorin PF02087.10 ESA08793.1 - 0.011 15.4 0.3 0.02 14.6 0.1 1.5 1 1 0 1 1 1 0 Nitrophorin Sel1 PF08238.7 ESA08794.1 - 1.3e-32 111.4 22.7 5.5e-08 33.2 0.2 6.9 7 0 0 7 7 7 6 Sel1 repeat Apc3 PF12895.2 ESA08794.1 - 0.091 12.9 13.5 0.084 13.0 2.3 3.6 1 1 3 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA08794.1 - 1.2 9.2 10.3 2.7 8.1 1.2 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat BTB PF00651.26 ESA08795.1 - 1.3e-19 70.2 0.2 3.4e-19 68.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA08795.1 - 5.2e-10 39.0 1.6 2.6e-08 33.6 0.2 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA08795.1 - 2e-05 24.6 0.1 0.00015 21.7 0.0 2.4 2 0 0 2 2 2 1 TLD Hydrolase_3 PF08282.7 ESA08795.1 - 0.072 12.6 0.7 0.14 11.7 0.5 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Sec2p PF06428.6 ESA08797.1 - 0.15 11.9 1.2 0.27 11.0 0.8 1.4 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Vpu PF00558.14 ESA08798.1 - 0.89 9.1 5.5 6.8 6.3 0.0 2.2 1 1 1 2 2 2 0 Vpu protein RNA_pol_Rpb1_1 PF04997.7 ESA08800.1 - 5e-71 239.6 0.2 7.7e-71 239.0 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 ESA08800.1 - 1.5e-67 226.6 0.0 3.9e-67 225.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.12 ESA08800.1 - 6.6e-64 215.8 0.1 3.1e-63 213.6 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.13 ESA08800.1 - 2.2e-38 131.4 0.0 5.3e-38 130.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 ESA08800.1 - 9.1e-32 109.0 0.0 2.7e-31 107.5 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 WD40 PF00400.27 ESA08801.1 - 1.2e-07 31.2 0.3 1.2e-07 31.2 0.2 2.5 3 0 0 3 3 3 1 WD domain, G-beta repeat PX PF00787.19 ESA08803.1 - 3e-15 55.9 0.1 5.4e-15 55.1 0.1 1.5 1 0 0 1 1 1 1 PX domain SNARE PF05739.14 ESA08803.1 - 5.6e-07 29.1 2.4 5.6e-07 29.1 0.4 2.0 2 0 0 2 2 2 1 SNARE domain Methyltransf_23 PF13489.1 ESA08805.1 - 1.8e-12 47.2 0.0 2.6e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA08805.1 - 1.6e-10 41.3 0.0 3e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA08805.1 - 3.6e-10 39.6 0.4 3.1e-09 36.6 0.3 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA08805.1 - 6.6e-10 39.2 0.0 1.3e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA08805.1 - 2.6e-07 31.0 0.0 5.8e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA08805.1 - 5.4e-06 26.9 0.0 2e-05 25.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA08805.1 - 4.8e-05 22.8 0.0 0.0001 21.7 0.0 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 ESA08805.1 - 0.00017 20.7 0.0 0.001 18.2 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA08805.1 - 0.00062 18.8 0.4 0.013 14.5 0.0 2.9 3 1 1 4 4 4 1 Putative methyltransferase CheR PF01739.13 ESA08805.1 - 0.00089 18.5 2.2 0.0088 15.3 0.0 2.4 3 0 0 3 3 3 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.14 ESA08805.1 - 0.13 12.2 0.2 0.29 11.1 0.1 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase GerE PF00196.14 ESA08806.1 - 0.032 13.5 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 ESA08806.1 - 0.034 13.7 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain Sigma70_r4_2 PF08281.7 ESA08806.1 - 0.035 13.5 0.1 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 Herpes_UL31 PF02718.9 ESA08806.1 - 0.04 12.6 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL31-like protein Vac_Fusion PF02346.11 ESA08807.1 - 0.04 13.3 0.5 0.049 13.0 0.3 1.2 1 0 0 1 1 1 0 Chordopoxvirus fusion protein Pol_alpha_B_N PF08418.5 ESA08809.1 - 4.1 6.8 7.3 5.1 6.5 5.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF1542 PF07564.6 ESA08810.1 - 0.2 11.7 2.0 0.25 11.3 0.4 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) HRDC PF00570.18 ESA08811.1 - 0.029 14.0 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 HRDC domain Phosducin PF02114.11 ESA08812.1 - 0.056 12.1 0.0 0.064 11.9 0.0 1.1 1 0 0 1 1 1 0 Phosducin DNA_pol_B_3 PF08408.5 ESA08812.1 - 0.062 13.1 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase family B viral insert HMG_box PF00505.14 ESA08814.1 - 1.8e-18 66.5 3.5 2.5e-18 66.1 2.4 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA08814.1 - 7.7e-08 32.5 3.7 1.2e-07 31.9 2.5 1.3 1 0 0 1 1 1 1 HMG-box domain DUF1138 PF06592.8 ESA08814.1 - 0.099 12.6 0.4 0.15 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1138) Glyco_hydro_108 PF05838.7 ESA08814.1 - 0.1 12.7 0.2 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase 108 Ion_trans PF00520.26 ESA08815.1 - 1.5e-06 27.6 10.6 1.8e-06 27.3 7.4 1.3 1 0 0 1 1 1 1 Ion transport protein USP7_ICP0_bdg PF12436.3 ESA08816.1 - 2.8e-110 367.4 22.9 2.7e-59 200.4 1.7 4.1 4 0 0 4 4 4 3 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA08816.1 - 1.8e-57 194.2 8.2 1.8e-57 194.2 5.7 4.3 3 1 2 5 5 5 1 Ubiquitin-specific protease C-terminal ubiquitin PF00240.18 ESA08816.1 - 0.0034 16.7 0.2 2.5 7.5 0.1 2.9 2 0 0 2 2 2 2 Ubiquitin family TipAS PF07739.8 ESA08816.1 - 0.0048 17.2 0.0 0.18 12.1 0.0 2.5 2 0 0 2 2 2 1 TipAS antibiotic-recognition domain Apolipoprotein PF01442.13 ESA08816.1 - 0.0051 16.3 0.0 0.52 9.7 0.0 2.2 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain UN_NPL4 PF11543.3 ESA08816.1 - 1.5 9.1 5.6 5.4 7.3 0.0 3.8 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 USP7_ICP0_bdg PF12436.3 ESA08817.1 - 1.1e-58 198.3 4.4 2.1e-53 181.1 2.1 2.2 2 0 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 ubiquitin PF00240.18 ESA08817.1 - 0.027 13.8 0.0 3.3 7.1 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin family Rad60-SLD PF11976.3 ESA08817.1 - 0.079 12.6 0.3 1.9 8.2 0.0 2.9 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like CENP-B_N PF04218.8 ESA08817.1 - 0.083 12.3 0.0 6.4 6.2 0.0 2.4 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain TLD PF07534.11 ESA08819.1 - 1.9e-07 31.1 3.9 4.2e-07 30.0 2.7 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA08819.1 - 2.7e-06 27.1 2.4 1.1e-05 25.1 0.0 2.9 4 0 0 4 4 4 1 BTB And C-terminal Kelch Holin_LLH PF09682.5 ESA08820.1 - 0.086 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Phage holin protein (Holin_LLH) DUF1998 PF09369.5 ESA08821.1 - 0.26 11.8 2.3 3.5 8.2 1.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1998) Rad60-SLD PF11976.3 ESA08822.1 - 0.023 14.3 0.4 0.049 13.3 0.3 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF1904 PF08921.6 ESA08822.1 - 0.025 14.6 0.1 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) RRXRR PF14239.1 ESA08822.1 - 0.072 12.4 5.8 0.27 10.6 3.4 1.9 2 0 0 2 2 2 0 RRXRR protein FAR1 PF03101.10 ESA08823.1 - 7.1e-09 36.0 1.0 1.1e-08 35.4 0.7 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA08823.1 - 0.017 14.7 0.1 2 8.0 0.0 2.4 2 0 0 2 2 2 0 MuDR family transposase Pkinase_Tyr PF07714.12 ESA08825.1 - 4e-09 35.9 0.0 7.2e-07 28.5 0.0 3.2 4 0 0 4 4 4 1 Protein tyrosine kinase BCS1_N PF08740.6 ESA08825.1 - 5.8e-06 26.0 1.9 0.076 12.6 0.0 4.7 6 0 0 6 6 6 2 BCS1 N terminal Pkinase PF00069.20 ESA08825.1 - 0.00019 20.6 0.1 0.0005 19.3 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Zn_Tnp_IS91 PF14319.1 ESA08825.1 - 0.0093 15.4 16.2 1.6 8.2 0.3 4.3 4 0 0 4 4 4 3 Transposase zinc-binding domain A2L_zn_ribbon PF08792.5 ESA08825.1 - 0.031 13.7 0.6 0.031 13.7 0.4 5.1 4 1 1 5 5 5 0 A2L zinc ribbon domain DUF4413 PF14372.1 ESA08825.1 - 0.11 12.5 3.6 8 6.5 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) zf-TFIIIC PF12660.2 ESA08825.1 - 8.1 6.4 11.7 7.3 6.5 0.1 4.0 4 1 1 5 5 5 0 Putative zinc-finger of transcription factor IIIC complex PCI_Csn8 PF10075.4 ESA08826.1 - 1.4e-30 105.9 0.2 2.2e-30 105.3 0.1 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESA08826.1 - 7.2e-30 104.0 0.4 1.1e-29 103.4 0.3 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family DcpS_C PF11969.3 ESA08827.1 - 1.1e-29 102.9 0.8 2.7e-29 101.7 0.6 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 ESA08827.1 - 2.1e-17 63.4 0.1 4.3e-17 62.4 0.1 1.5 1 0 0 1 1 1 1 HIT domain DUF3785 PF12653.2 ESA08827.1 - 0.02 14.7 0.6 0.087 12.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3785) Ribosomal_L18e PF00828.14 ESA08829.1 - 1.6e-35 122.2 0.9 2.5e-35 121.6 0.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 RAP PF08373.5 ESA08829.1 - 0.064 13.0 1.1 0.13 12.0 0.7 1.6 2 0 0 2 2 2 0 RAP domain Rhodanese PF00581.15 ESA08830.1 - 1.2e-15 57.8 0.0 2.7e-15 56.6 0.0 1.6 2 0 0 2 2 2 1 Rhodanese-like domain DUF2498 PF10692.4 ESA08830.1 - 0.13 11.9 0.0 0.31 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2498) bZIP_C PF12498.3 ESA08831.1 - 0.92 10.7 5.2 1.2 10.3 3.6 1.3 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Macoilin PF09726.4 ESA08831.1 - 1 7.5 10.2 1.1 7.4 7.1 1.0 1 0 0 1 1 1 0 Transmembrane protein COX6A PF02046.10 ESA08831.1 - 1.3 8.9 9.9 0.22 11.4 4.1 1.7 1 1 1 2 2 2 0 Cytochrome c oxidase subunit VIa SelP_N PF04592.9 ESA08831.1 - 2.9 7.2 17.9 3.3 7.0 12.4 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TPR_16 PF13432.1 ESA08832.1 - 9e-05 23.0 0.0 0.00028 21.4 0.0 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA08832.1 - 0.00046 20.2 0.3 0.0019 18.2 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA08832.1 - 0.0064 16.8 0.8 0.25 11.7 0.1 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA08832.1 - 0.015 14.9 0.2 0.025 14.2 0.1 1.5 1 0 0 1 1 1 0 TPR repeat TPR_9 PF13371.1 ESA08832.1 - 0.055 13.3 0.0 0.32 10.8 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA08832.1 - 0.072 13.0 0.1 0.29 11.1 0.0 1.9 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA08832.1 - 0.078 13.4 0.7 4.8 7.8 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4611 PF15387.1 ESA08832.1 - 0.99 9.5 5.7 2.1 8.5 3.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.7 ESA08832.1 - 4.3 6.5 13.8 5.5 6.1 9.6 1.1 1 0 0 1 1 1 0 NOA36 protein Bd3614_N PF14442.1 ESA08832.1 - 5.3 7.0 8.9 7.9 6.4 6.2 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal BTB PF00651.26 ESA08833.1 - 3e-16 59.3 0.0 1.4e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA08833.1 - 0.0091 15.8 0.2 0.073 12.9 0.0 2.3 2 1 1 3 3 3 1 BTB And C-terminal Kelch DNA_pol_viral_N PF00242.12 ESA08833.1 - 0.079 11.9 1.1 0.13 11.2 0.7 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain FCP1_C PF09309.5 ESA08833.1 - 0.2 10.9 6.5 0.31 10.3 4.5 1.2 1 0 0 1 1 1 0 FCP1, C-terminal RCC1 PF00415.13 ESA08835.1 - 2.1e-58 194.3 0.0 1.7e-10 40.9 0.0 8.2 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESA08835.1 - 2.4e-37 125.7 22.2 3e-08 33.0 0.0 7.9 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat zf-MIZ PF02891.15 ESA08836.1 - 2e-05 23.9 3.4 3.6e-05 23.1 2.4 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Surface_Ag_2 PF01617.12 ESA08837.1 - 0.06 12.5 1.0 0.069 12.3 0.7 1.2 1 0 0 1 1 1 0 Surface antigen SE PF08491.5 ESA08837.1 - 0.079 11.7 0.2 0.094 11.5 0.1 1.2 1 0 0 1 1 1 0 Squalene epoxidase DMAP1 PF05499.7 ESA08837.1 - 1.1 8.8 6.4 0.41 10.1 1.0 2.0 1 1 1 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Bromodomain PF00439.20 ESA08838.1 - 3e-16 59.0 0.3 3.2e-16 59.0 0.2 1.0 1 0 0 1 1 1 1 Bromodomain Pkinase_Tyr PF07714.12 ESA08840.1 - 1.7e-14 53.5 0.0 2.3e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08840.1 - 1.5e-13 50.5 0.0 2.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Fork_head PF00250.13 ESA08840.1 - 0.045 13.7 0.2 0.074 13.1 0.1 1.4 1 0 0 1 1 1 0 Fork head domain E1-E2_ATPase PF00122.15 ESA08842.1 - 8.2e-06 25.0 0.2 8.2e-06 25.0 0.1 2.2 2 1 0 2 2 2 1 E1-E2 ATPase ASFV_J13L PF05568.6 ESA08842.1 - 0.38 10.2 3.2 2.9 7.3 0.1 2.3 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF3474 PF11960.3 ESA08842.1 - 0.43 10.6 2.8 4.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) DUF4097 PF13349.1 ESA08842.1 - 2.5 7.5 12.4 4.9 6.6 4.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4097) Sigma_reg_N PF13800.1 ESA08842.1 - 5.4 7.1 13.1 2.6 8.1 1.1 2.9 2 1 0 2 2 2 0 Sigma factor regulator N-terminal Mpv17_PMP22 PF04117.7 ESA08843.1 - 1.1e-26 92.1 0.7 2.2e-26 91.2 0.5 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family Pkinase PF00069.20 ESA08844.1 - 2.8e-67 226.6 0.0 6.1e-67 225.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08844.1 - 3.5e-37 127.8 0.1 1.3e-36 126.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase C1_1 PF00130.17 ESA08844.1 - 3.4e-17 61.8 30.1 1.1e-09 37.8 7.4 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.11 ESA08844.1 - 1.7e-15 56.4 16.3 4.8e-11 42.2 2.7 2.8 3 0 0 3 3 3 2 Hr1 repeat Pkinase_C PF00433.19 ESA08844.1 - 1.6e-12 47.6 0.5 1.6e-12 47.6 0.3 2.5 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.25 ESA08844.1 - 7.8e-09 35.2 0.0 1.7e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.1 ESA08844.1 - 0.0086 15.0 0.0 0.029 13.3 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Ten1_2 PF15490.1 ESA08845.1 - 1.8e-07 30.7 0.2 3.5e-07 29.8 0.2 1.4 1 1 0 1 1 1 1 Telomere-capping, CST complex subunit UVR PF02151.14 ESA08846.1 - 5.6e-08 32.0 16.9 4e-06 26.1 1.6 5.9 5 0 0 5 5 5 3 UvrB/uvrC motif HEAT PF02985.17 ESA08847.1 - 1.8e-12 46.2 11.9 0.052 13.6 0.0 9.3 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.1 ESA08847.1 - 1.6e-11 44.2 0.6 0.0028 17.8 0.0 6.0 5 1 1 6 6 6 3 HEAT repeats HEAT_EZ PF13513.1 ESA08847.1 - 1.6e-07 31.5 3.3 0.061 13.8 0.0 6.0 6 0 0 6 6 6 2 HEAT-like repeat Arm PF00514.18 ESA08847.1 - 0.00028 20.6 3.5 0.031 14.1 0.1 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat F-box-like PF12937.2 ESA08851.1 - 0.001 18.7 1.8 0.0016 18.1 0.3 2.1 2 0 0 2 2 2 1 F-box-like EI24 PF07264.6 ESA08853.1 - 2e-42 145.1 20.8 2.6e-42 144.7 14.4 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF4112 PF13430.1 ESA08853.1 - 0.035 14.0 0.0 0.084 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) ARPC4 PF05856.7 ESA08854.1 - 1.7e-15 56.8 0.6 1.9e-15 56.6 0.4 1.1 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) LRR_8 PF13855.1 ESA08857.1 - 0.28 10.9 13.1 0.91 9.3 2.0 3.8 3 1 1 4 4 4 0 Leucine rich repeat LRR_6 PF13516.1 ESA08857.1 - 0.44 10.7 4.1 8.8 6.7 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich repeat PIG-L PF02585.12 ESA08858.1 - 1.6e-24 86.8 0.0 2.3e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF1647 PF07801.6 ESA08858.1 - 2.9 7.4 10.0 1.1 8.7 0.6 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1647) BTB PF00651.26 ESA08859.1 - 7.2e-10 38.8 0.4 2.6e-08 33.8 0.3 2.5 1 1 0 1 1 1 1 BTB/POZ domain Yqai PF09466.5 ESA08859.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Hypothetical protein Yqai DUF1635 PF07795.6 ESA08859.1 - 0.19 11.0 3.6 0.28 10.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) WD40 PF00400.27 ESA08860.1 - 1.1e-35 120.1 3.6 2.8e-09 36.5 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Peptidase_M20 PF01546.23 ESA08860.1 - 3.8e-27 95.0 0.0 7.6e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESA08860.1 - 1.6e-14 53.6 0.0 4.6e-14 52.1 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Glu_cyclase_2 PF05096.7 ESA08860.1 - 0.00018 20.6 0.0 0.54 9.2 0.0 2.2 2 0 0 2 2 2 2 Glutamine cyclotransferase Nup160 PF11715.3 ESA08860.1 - 0.00033 18.9 0.2 0.0013 16.9 0.0 2.0 3 0 0 3 3 3 1 Nucleoporin Nup120/160 YscJ_FliF PF01514.12 ESA08860.1 - 0.18 10.9 0.0 0.7 9.0 0.0 1.9 2 0 0 2 2 2 0 Secretory protein of YscJ/FliF family PQQ_3 PF13570.1 ESA08860.1 - 0.58 10.5 4.8 1.2e+02 3.1 0.1 5.3 5 1 1 6 6 6 0 PQQ-like domain Rad17 PF03215.10 ESA08861.1 - 2e-24 86.1 2.1 2e-24 86.1 1.4 2.4 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 ESA08861.1 - 3.5e-05 23.4 0.0 7.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain T2SE PF00437.15 ESA08861.1 - 0.00053 18.9 0.1 0.0012 17.7 0.0 1.6 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_11 PF13086.1 ESA08861.1 - 0.00078 19.0 0.3 0.002 17.7 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA08861.1 - 0.0027 18.5 0.1 0.033 15.0 0.0 2.7 2 2 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA08861.1 - 0.0028 16.7 0.0 0.0062 15.6 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 ESA08861.1 - 0.0031 17.8 0.7 0.061 13.6 0.0 3.2 2 2 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA08861.1 - 0.0066 16.5 0.0 0.015 15.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA08861.1 - 0.0085 16.0 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.10 ESA08861.1 - 0.024 14.3 0.2 0.17 11.5 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA PF00004.24 ESA08861.1 - 0.025 14.7 0.0 0.087 13.0 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 ESA08861.1 - 0.026 13.7 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 cobW PF02492.14 ESA08861.1 - 0.05 13.0 0.1 0.089 12.2 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 ESA08861.1 - 0.053 13.4 0.1 0.3 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 ESA08861.1 - 0.054 13.0 0.0 0.09 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 ESA08861.1 - 0.055 12.3 0.4 0.26 10.1 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.1 ESA08861.1 - 0.067 13.0 0.0 0.15 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA08861.1 - 0.087 13.1 0.2 0.38 11.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter IstB_IS21 PF01695.12 ESA08861.1 - 0.13 11.6 0.0 0.33 10.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein zf-CCCH PF00642.19 ESA08862.1 - 3.3e-12 45.7 13.0 2.3e-06 27.1 2.0 2.8 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 ESA08862.1 - 8.2e-09 35.1 0.3 2.1e-08 33.8 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA08862.1 - 1.9e-07 30.5 0.0 4.8e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA08862.1 - 0.0077 16.1 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA08862.1 - 0.035 13.8 0.2 0.099 12.4 0.1 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif LAT PF15234.1 ESA08863.1 - 0.0033 16.9 0.6 0.0055 16.1 0.4 1.3 1 0 0 1 1 1 1 Linker for activation of T-cells Alkyl_sulf_C PF14864.1 ESA08863.1 - 0.012 15.6 0.4 0.016 15.1 0.3 1.3 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal DUF4342 PF14242.1 ESA08863.1 - 0.18 11.5 1.5 0.49 10.2 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) SpaB_C PF14028.1 ESA08863.1 - 0.51 9.8 3.0 0.61 9.6 1.9 1.2 1 1 0 1 1 1 0 SpaB C-terminal domain Hom_end_hint PF05203.11 ESA08863.1 - 2.2 7.9 11.4 2.8 7.6 7.9 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint GCV_H PF01597.14 ESA08864.1 - 0.0042 16.7 0.1 0.0063 16.2 0.0 1.5 1 1 0 1 1 1 1 Glycine cleavage H-protein RRM_1 PF00076.17 ESA08865.1 - 3.9e-23 80.8 0.1 4.8e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA08865.1 - 8.3e-19 67.3 0.0 1e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA08865.1 - 2.2e-12 46.6 0.0 2.9e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GRP PF07172.6 ESA08865.1 - 0.00042 20.7 33.1 0.00063 20.1 22.9 1.4 1 0 0 1 1 1 1 Glycine rich protein family FAR1 PF03101.10 ESA08867.1 - 0.54 10.8 3.7 30 5.2 2.6 2.3 1 1 0 1 1 1 0 FAR1 DNA-binding domain MFS_1 PF07690.11 ESA08869.1 - 1.5e-34 119.3 29.0 1.8e-34 119.0 15.5 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA08869.1 - 6.3e-07 28.3 7.4 6.3e-07 28.3 5.1 3.1 3 0 0 3 3 3 2 Sugar (and other) transporter PTR2 PF00854.16 ESA08869.1 - 2.3e-05 23.3 0.8 2.3e-05 23.3 0.5 1.8 2 0 0 2 2 2 1 POT family MFS_2 PF13347.1 ESA08869.1 - 0.00027 19.4 9.7 0.0061 15.0 0.0 3.1 2 1 1 3 3 3 2 MFS/sugar transport protein ATG22 PF11700.3 ESA08869.1 - 0.00033 19.2 2.4 0.00089 17.8 1.7 1.7 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like OATP PF03137.15 ESA08869.1 - 0.023 12.7 9.1 0.25 9.3 0.2 3.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF4131 PF13567.1 ESA08869.1 - 0.16 11.3 14.8 0.026 13.9 2.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) TRI12 PF06609.8 ESA08869.1 - 0.28 9.3 5.0 0.073 11.2 1.1 1.7 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Corona_S2 PF01601.11 ESA08869.1 - 0.35 8.9 5.6 0.59 8.1 3.9 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RseC_MucC PF04246.7 ESA08869.1 - 0.57 9.7 6.0 0.14 11.7 0.3 2.7 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DUF1269 PF06897.7 ESA08869.1 - 0.63 10.0 1.8 5.2 7.1 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) Sigma_reg_N PF13800.1 ESA08869.1 - 1.7 8.7 7.5 2.4 8.2 0.0 3.5 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF204 PF02659.10 ESA08869.1 - 2.5 8.2 17.1 1.6 8.8 4.3 3.3 3 0 0 3 3 3 0 Domain of unknown function DUF DUF1275 PF06912.6 ESA08869.1 - 4.9 6.2 9.8 0.31 10.1 1.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1275) Conotoxin PF02950.12 ESA08871.1 - 0.7 10.7 9.3 12 6.7 6.5 2.1 1 1 0 1 1 1 0 Conotoxin SNF2_N PF00176.18 ESA08872.1 - 1.9e-74 250.1 0.2 3.7e-74 249.2 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESA08872.1 - 1.8e-12 46.9 0.0 6.4e-12 45.1 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.1 ESA08872.1 - 1.3e-10 41.0 7.8 3e-10 39.9 5.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA08872.1 - 3.5e-09 36.2 5.8 6.4e-09 35.3 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA08872.1 - 8.5e-09 35.1 6.8 1.6e-08 34.2 4.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA08872.1 - 6.3e-08 32.1 7.0 1.3e-07 31.1 4.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA08872.1 - 2e-07 30.6 6.4 4e-07 29.6 4.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.24 ESA08872.1 - 1.7e-06 27.6 0.0 4.1e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_4 PF15227.1 ESA08872.1 - 5.7e-05 22.9 9.2 0.00012 21.9 6.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA08872.1 - 0.00073 19.2 2.4 0.0016 18.0 1.0 2.3 1 1 0 1 1 1 1 RING-type zinc-finger UBA_4 PF14555.1 ESA08872.1 - 0.00085 18.8 0.1 0.0022 17.4 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain zf-RING_4 PF14570.1 ESA08872.1 - 0.56 9.8 6.4 1.4 8.5 4.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CNH PF00780.17 ESA08873.1 - 6e-12 45.5 0.0 0.0012 18.3 0.0 3.6 3 1 1 4 4 4 3 CNH domain DUF605 PF04652.11 ESA08873.1 - 0.037 13.4 0.8 0.053 12.9 0.6 1.3 1 0 0 1 1 1 0 Vta1 like Auxin_repressed PF05564.7 ESA08873.1 - 0.5 10.9 16.3 0.23 12.0 0.5 3.2 2 1 1 3 3 3 0 Dormancy/auxin associated protein DUF843 PF05814.6 ESA08876.1 - 0.064 13.0 2.9 0.089 12.5 1.7 1.5 1 1 0 1 1 1 0 Baculovirus protein of unknown function (DUF843) Mu-like_Com PF10122.4 ESA08876.1 - 0.07 12.1 0.2 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Mu-like prophage protein Com CCSMST1 PF15013.1 ESA08876.1 - 0.3 11.0 0.2 0.3 11.0 0.1 2.3 1 1 1 2 2 2 0 CCSMST1 family YusW PF14039.1 ESA08878.1 - 0.041 14.1 0.6 0.048 13.9 0.4 1.3 1 0 0 1 1 1 0 YusW-like protein Hormone_1 PF00103.15 ESA08878.1 - 0.13 11.6 4.6 0.16 11.2 3.2 1.0 1 0 0 1 1 1 0 Somatotropin hormone family DUF1764 PF08576.5 ESA08878.1 - 3.6 8.4 6.7 5 7.9 4.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Pkinase PF00069.20 ESA08882.1 - 2.3e-09 36.8 0.0 2.6e-09 36.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08882.1 - 1.8e-08 33.7 0.0 2.1e-08 33.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Asp23 PF03780.8 ESA08883.1 - 0.061 13.6 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Asp23 family NusB PF01029.13 ESA08884.1 - 6.6 6.7 12.1 0.63 10.0 1.0 2.9 2 1 0 2 2 2 0 NusB family DTHCT PF08070.6 ESA08885.1 - 0.2 12.3 4.6 0.82 10.3 3.2 2.2 1 0 0 1 1 1 0 DTHCT (NUC029) region Pneumo_M2 PF07380.6 ESA08887.1 - 0.24 11.4 6.6 1.3 9.0 0.8 2.5 1 1 1 2 2 2 0 Pneumovirus M2 protein BACK PF07707.10 ESA08888.1 - 4.6e-06 26.4 4.9 5.4e-06 26.1 1.2 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF4485 PF14846.1 ESA08889.1 - 0.034 13.8 0.2 0.11 12.2 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4485) Cytochrom_B562 PF07361.6 ESA08889.1 - 0.04 14.3 0.1 0.095 13.1 0.1 1.6 1 0 0 1 1 1 0 Cytochrome b562 DPM3 PF08285.6 ESA08889.1 - 0.045 13.5 0.2 0.17 11.7 0.1 1.9 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) MreB_Mbl PF06723.8 ESA08890.1 - 1.4e-05 23.9 0.0 0.026 13.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein tRNA_synt_1c_R1 PF04558.10 ESA08892.1 - 7.4e-51 171.9 1.9 7.6e-51 171.8 0.8 1.4 1 1 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c PF00749.16 ESA08892.1 - 4.7e-19 68.1 1.0 2.3e-17 62.6 0.5 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R2 PF04557.10 ESA08892.1 - 6.2e-15 55.6 7.5 6.2e-15 55.6 5.2 1.8 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 UPF0546 PF10639.4 ESA08893.1 - 3.8e-43 145.9 3.2 4.4e-43 145.6 2.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 EamA PF00892.15 ESA08893.1 - 0.002 18.1 6.5 0.018 15.1 4.5 2.0 1 1 0 1 1 1 1 EamA-like transporter family EmrE PF13536.1 ESA08893.1 - 0.0089 16.2 4.5 0.016 15.3 3.1 1.5 1 1 0 1 1 1 1 Multidrug resistance efflux transporter Pkinase_Tyr PF07714.12 ESA08894.1 - 2.3e-26 92.4 0.0 3.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08894.1 - 8e-25 87.4 0.0 1.5e-24 86.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain MORN_2 PF07661.8 ESA08894.1 - 0.11 12.6 3.0 1.1 9.5 0.4 3.1 2 0 0 2 2 2 0 MORN repeat variant Cytochrom_B558a PF05038.8 ESA08895.1 - 0.00043 19.9 3.7 0.0052 16.4 0.1 2.2 2 1 0 2 2 2 2 Cytochrome Cytochrome b558 alpha-subunit MerC PF03203.9 ESA08895.1 - 0.065 13.6 1.3 0.19 12.1 0.2 1.9 1 1 1 2 2 2 0 MerC mercury resistance protein COPI_assoc PF08507.5 ESA08895.1 - 0.13 11.9 9.5 0.23 11.1 6.6 1.5 1 1 0 1 1 1 0 COPI associated protein DUF2892 PF11127.3 ESA08895.1 - 0.63 9.9 3.6 13 5.7 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) DUF308 PF03729.8 ESA08895.1 - 3.2 7.8 11.8 3 7.9 1.4 3.0 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) SQS_PSY PF00494.14 ESA08896.1 - 2e-38 132.2 0.0 2.2e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase MIR PF02815.14 ESA08897.1 - 0.0048 16.4 0.3 0.051 13.1 0.2 2.4 1 1 0 1 1 1 1 MIR domain Ins145_P3_rec PF08709.6 ESA08897.1 - 0.042 12.8 0.3 0.25 10.3 0.2 2.2 1 1 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF4430 PF14478.1 ESA08897.1 - 0.087 12.8 0.1 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) SWIM PF04434.12 ESA08898.1 - 0.15 11.5 1.5 0.26 10.7 1.0 1.4 1 0 0 1 1 1 0 SWIM zinc finger MMR_HSR1 PF01926.18 ESA08899.1 - 8.2e-16 58.0 0.0 1.7e-12 47.3 0.0 2.9 3 1 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA08899.1 - 5.4e-07 29.0 0.1 8.4e-05 21.8 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 ESA08899.1 - 1.2e-05 24.6 0.1 2.8e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESA08899.1 - 0.0001 21.8 1.5 0.24 10.8 0.1 2.8 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESA08899.1 - 0.001 18.9 0.0 0.001 18.9 0.0 3.1 3 0 0 3 3 3 1 Dynamin family AIG1 PF04548.11 ESA08899.1 - 0.0023 17.0 2.7 0.0091 15.1 0.1 2.6 2 1 0 2 2 2 1 AIG1 family Miro PF08477.8 ESA08899.1 - 0.017 15.6 0.1 0.11 13.0 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein BDV_P24 PF06595.6 ESA08899.1 - 0.15 11.7 7.6 0.032 14.0 0.9 2.6 3 0 0 3 3 3 0 Borna disease virus P24 protein Rpr2 PF04032.11 ESA08903.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.7 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Mut7-C PF01927.11 ESA08903.1 - 5.8 6.8 9.9 0.42 10.5 0.2 3.0 2 1 0 3 3 3 0 Mut7-C RNAse domain FLYWCH PF04500.11 ESA08904.1 - 8.7e-11 41.5 7.5 8.7e-11 41.5 5.2 2.1 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.4 ESA08904.1 - 0.0015 18.6 0.1 0.012 15.7 0.0 2.6 3 0 0 3 3 3 1 MULE transposase domain Vac_ImportDeg PF09783.4 ESA08905.1 - 2.1e-59 199.9 1.1 2.5e-59 199.7 0.8 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein Kelch_5 PF13854.1 ESA08906.1 - 1.3e-20 72.8 7.4 8.8e-07 28.7 0.0 4.6 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 ESA08906.1 - 1.9e-20 72.3 6.6 5.4e-05 22.8 0.0 4.5 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA08906.1 - 4.2e-17 61.7 10.7 9e-05 22.5 0.0 5.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA08906.1 - 8.8e-14 50.7 8.5 5.9e-05 22.5 0.8 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 ESA08906.1 - 2.6e-13 49.5 8.6 1.9e-05 24.5 0.2 4.5 2 1 2 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESA08906.1 - 1.3e-05 24.7 0.6 0.098 12.4 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Rax2 PF12768.2 ESA08906.1 - 0.0011 18.2 3.1 0.04 13.1 0.1 3.1 1 1 2 3 3 3 1 Cortical protein marker for cell polarity Transposase_24 PF03004.9 ESA08908.1 - 0.3 10.9 4.2 2.2 8.1 2.9 2.2 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) DUF4413 PF14372.1 ESA08909.1 - 0.0041 17.0 5.2 0.55 10.2 0.2 3.1 2 1 0 2 2 2 2 Domain of unknown function (DUF4413) SpoU_methylas_C PF12105.3 ESA08909.1 - 0.065 12.8 0.0 6.2 6.4 0.0 2.7 2 0 0 2 2 2 0 SpoU, rRNA methylase, C-terminal DUF3078 PF11276.3 ESA08909.1 - 2.9 8.1 8.1 2 8.6 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3078) LysM PF01476.15 ESA08911.1 - 9.9e-11 41.3 0.0 1.3e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 LysM domain DUF3955 PF13127.1 ESA08911.1 - 0.12 11.9 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) DUF4604 PF15377.1 ESA08918.1 - 0.032 14.4 15.0 0.04 14.1 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) GAGA_bind PF06217.7 ESA08918.1 - 0.71 9.7 10.1 0.78 9.6 7.0 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.7 ESA08918.1 - 2 8.2 10.3 2.5 7.9 7.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.12 ESA08918.1 - 2.3 7.9 10.5 2.6 7.7 7.3 1.1 1 0 0 1 1 1 0 DDHD domain Herpes_DNAp_acc PF04929.7 ESA08918.1 - 6.4 5.6 8.7 6.3 5.6 6.1 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor GPW_gp25 PF04965.9 ESA08919.1 - 0.044 13.3 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 Gene 25-like lysozyme DUF4604 PF15377.1 ESA08919.1 - 0.068 13.3 16.4 0.12 12.5 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Pkinase_Tyr PF07714.12 ESA08920.1 - 3.4e-12 45.9 0.0 3.6e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08920.1 - 2.1e-07 30.3 0.2 1.2e-06 27.9 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain TLD PF07534.11 ESA08921.1 - 1.5e-10 41.2 0.9 3.5e-10 40.0 0.1 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA08921.1 - 6.5e-05 22.7 1.3 0.0011 18.7 0.2 2.9 2 1 0 2 2 2 1 BTB And C-terminal Kelch Chorismate_bind PF00425.13 ESA08923.1 - 1.6e-77 260.3 0.0 4.4e-77 258.8 0.0 1.7 1 1 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 ESA08923.1 - 4.7e-13 49.3 0.1 1.6e-12 47.5 0.0 1.9 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region MULE PF10551.4 ESA08925.1 - 7e-12 45.3 0.1 7.8e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 MULE transposase domain Dimer_Tnp_hAT PF05699.9 ESA08926.1 - 1e-17 63.5 0.3 1.1e-17 63.4 0.2 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TrmE_N PF10396.4 ESA08928.1 - 1.3e-38 131.4 0.0 2.9e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus GTPase_Cys_C PF12631.2 ESA08928.1 - 1.1e-21 76.9 3.5 1.2e-21 76.8 0.8 2.2 2 0 0 2 2 2 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE MMR_HSR1 PF01926.18 ESA08928.1 - 1.4e-18 66.9 0.2 5.8e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA08928.1 - 2.8e-06 27.2 0.0 7.7e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 ESA08928.1 - 2.9e-05 23.3 0.0 5.6e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 ESA08928.1 - 5.7e-05 23.5 0.0 0.00018 22.0 0.0 1.9 2 0 0 2 2 2 1 Miro-like protein AAA_17 PF13207.1 ESA08928.1 - 0.0015 19.3 0.1 0.026 15.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain cobW PF02492.14 ESA08928.1 - 0.0027 17.1 0.1 0.1 12.0 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PEP-utilisers_N PF05524.8 ESA08928.1 - 0.037 13.8 0.7 0.14 11.9 0.3 2.0 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal GTP_EFTU PF00009.22 ESA08928.1 - 0.051 12.9 0.0 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF1837 PF08878.6 ESA08929.1 - 0.54 9.8 5.7 1.2 8.7 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) Rpn3_C PF08375.6 ESA08931.1 - 7.6e-27 93.5 1.2 3.5e-26 91.3 0.5 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 ESA08931.1 - 2.2e-10 40.8 0.6 3.3e-10 40.1 0.1 1.5 2 0 0 2 2 2 1 PCI domain GatB_N PF02934.10 ESA08936.1 - 3.1e-107 357.7 0.0 4.1e-107 357.3 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 ESA08936.1 - 3e-40 137.3 0.3 5e-40 136.6 0.2 1.4 1 0 0 1 1 1 1 GatB domain Imm42 PF15601.1 ESA08940.1 - 0.069 12.5 0.7 0.1 12.0 0.5 1.2 1 0 0 1 1 1 0 Immunity protein 42 Myb_DNA-bind_6 PF13921.1 ESA08943.1 - 0.016 15.2 4.7 0.064 13.3 0.1 2.6 1 1 1 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA08943.1 - 0.17 11.9 3.3 0.56 10.2 0.5 2.7 2 2 0 2 2 2 0 Myb-like DNA-binding domain START PF01852.14 ESA08947.1 - 0.0013 18.0 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 START domain GAT PF03127.9 ESA08948.1 - 1.7e-16 60.0 1.0 4e-16 58.8 0.7 1.6 1 0 0 1 1 1 1 GAT domain VHS PF00790.14 ESA08948.1 - 1.9e-13 50.2 0.4 5.9e-13 48.6 0.0 2.0 2 1 1 3 3 3 1 VHS domain TLD PF07534.11 ESA08950.1 - 8.9e-15 54.8 0.9 1.8e-14 53.9 0.6 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA08950.1 - 2.1e-11 43.7 0.1 5.3e-11 42.5 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA08950.1 - 0.00033 20.4 2.8 0.0015 18.3 0.4 2.8 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF2960 PF11173.3 ESA08951.1 - 0.14 12.4 0.4 6 7.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2960) Pkinase PF00069.20 ESA08952.1 - 9.2e-41 139.7 0.0 1.6e-40 138.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA08952.1 - 3.1e-22 78.8 0.0 8.8e-22 77.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA08952.1 - 8.8e-09 34.7 0.0 4.9e-08 32.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESA08952.1 - 0.003 16.6 0.0 0.0066 15.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.2 ESA08953.1 - 1.5e-06 27.7 0.4 4.4e-06 26.3 0.3 1.8 1 0 0 1 1 1 1 F-box-like SNARE_assoc PF09335.6 ESA08954.1 - 1.2 9.3 7.6 0.095 12.9 2.2 1.5 2 0 0 2 2 2 0 SNARE associated Golgi protein DUF4043 PF13252.1 ESA08955.1 - 0.0059 15.6 0.3 0.0065 15.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4043) DUF3140 PF11338.3 ESA08955.1 - 0.011 15.8 0.2 0.013 15.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) DUF1283 PF06932.6 ESA08955.1 - 0.032 14.2 1.1 0.033 14.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) RNA_pol_Rpb2_4 PF04566.8 ESA08955.1 - 0.085 12.6 0.1 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 4 BBS2_C PF14782.1 ESA08955.1 - 0.088 11.3 2.6 0.091 11.3 1.8 1.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal CorA PF01544.13 ESA08957.1 - 1e-40 139.6 13.1 2e-35 122.2 6.0 2.1 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein Fib_alpha PF08702.5 ESA08957.1 - 2.2 8.4 5.4 3.4 7.7 1.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase_Tyr PF07714.12 ESA08958.1 - 8.2e-43 146.3 0.0 1e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08958.1 - 3.5e-36 124.6 0.0 5e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA08958.1 - 3.4e-05 23.0 0.0 6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA08958.1 - 0.0015 18.3 0.1 0.0029 17.3 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA08958.1 - 0.0052 15.7 0.0 0.0076 15.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EcKinase PF02958.15 ESA08958.1 - 0.019 14.1 0.2 0.047 12.8 0.0 1.6 2 0 0 2 2 2 0 Ecdysteroid kinase RIO1 PF01163.17 ESA08958.1 - 0.045 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.12 ESA08959.1 - 1.1e-17 63.9 0.0 1.3e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08959.1 - 2.1e-15 56.5 0.0 2.9e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SPRY PF00622.23 ESA08962.1 - 1.4e-18 67.1 0.7 1.8e-18 66.8 0.5 1.1 1 0 0 1 1 1 1 SPRY domain TLD PF07534.11 ESA08964.1 - 7.2e-10 39.0 0.7 1.6e-09 37.8 0.5 1.7 1 0 0 1 1 1 1 TLD TLD PF07534.11 ESA08965.1 - 5.5e-15 55.5 2.6 9.5e-15 54.8 1.8 1.4 1 0 0 1 1 1 1 TLD Gasdermin PF04598.7 ESA08965.1 - 0.16 10.7 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Gasdermin family DUF1829 PF08862.5 ESA08966.1 - 0.1 12.8 0.3 0.26 11.5 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF1829 WWbp PF10349.4 ESA08967.1 - 4.3 8.2 33.5 0.69 10.8 9.1 2.1 1 1 1 2 2 2 0 WW-domain ligand protein MTHFR_C PF12225.3 ESA08968.1 - 0.079 12.4 0.1 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal Sec1 PF00995.18 ESA08968.1 - 0.081 11.5 0.2 0.1 11.2 0.1 1.0 1 0 0 1 1 1 0 Sec1 family E1_dh PF00676.15 ESA08968.1 - 0.086 11.5 0.6 0.11 11.1 0.4 1.1 1 0 0 1 1 1 0 Dehydrogenase E1 component IFRD PF05004.8 ESA08968.1 - 0.16 11.0 2.3 0.45 9.5 0.6 1.9 1 1 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Pkinase_Tyr PF07714.12 ESA08969.1 - 5.6e-46 156.7 0.1 6.2e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA08969.1 - 1.4e-43 148.9 0.4 1.6e-43 148.7 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA08969.1 - 0.0003 20.1 0.2 0.00045 19.6 0.1 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA08969.1 - 0.00085 18.4 0.2 0.0011 18.0 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA08969.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA08969.1 - 0.018 14.0 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Kinase-like DUF3684 PF12449.3 ESA08970.1 - 5.8e-167 557.3 4.4 1.5e-162 542.7 1.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) TLD PF07534.11 ESA08971.1 - 4.5e-13 49.3 0.3 9.9e-13 48.2 0.0 1.7 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA08971.1 - 1.1e-12 47.8 0.2 6.3e-12 45.4 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA08971.1 - 9.3e-07 28.6 2.0 5.3e-06 26.2 0.2 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA08971.1 - 0.0089 15.2 0.1 0.018 14.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Dehyd-heme_bind PF09098.5 ESA08971.1 - 0.054 12.9 0.0 7 6.0 0.0 2.2 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding P63C PF10546.4 ESA08971.1 - 0.061 13.2 0.3 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 P63C domain DUF3317 PF11779.3 ESA08973.1 - 0.11 11.9 0.2 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) DUF4181 PF13789.1 ESA08973.1 - 0.13 12.2 0.7 0.13 12.2 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) Ras PF00071.17 ESA08975.1 - 9.2e-56 187.7 0.5 1.1e-55 187.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA08975.1 - 1.2e-19 70.9 0.1 1.8e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA08975.1 - 7.9e-19 67.5 0.2 9.6e-19 67.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA08975.1 - 1.2e-08 34.4 0.1 1.3e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESA08975.1 - 8.8e-07 28.8 0.0 1.3e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA08975.1 - 0.00049 19.5 0.1 0.00072 19.0 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESA08975.1 - 0.0045 16.2 0.2 0.011 14.8 0.1 1.7 1 1 0 2 2 2 1 Protein of unknown function, DUF258 DNA_pol3_delta2 PF13177.1 ESA08975.1 - 0.005 16.5 0.1 0.011 15.4 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit NTPase_1 PF03266.10 ESA08975.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.1 ESA08975.1 - 0.092 12.7 0.0 0.12 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Mito_carr PF00153.22 ESA08977.1 - 1.3e-79 261.9 0.8 7.2e-27 92.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Abhydro_lipase PF04083.11 ESA08978.1 - 7.5e-22 76.4 0.1 2.2e-21 74.9 0.0 1.8 1 1 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 ESA08978.1 - 5.8e-11 42.3 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESA08978.1 - 2.1e-07 31.0 0.0 3.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA08978.1 - 0.0083 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family BTB PF00651.26 ESA08979.1 - 1.3e-16 60.5 0.1 4.3e-16 58.8 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA08979.1 - 7.2e-07 28.9 3.6 2.1e-05 24.2 0.3 3.3 2 1 1 3 3 3 2 BTB And C-terminal Kelch SOG2 PF10428.4 ESA08981.1 - 8.9e-41 139.9 0.5 8.9e-41 139.9 0.4 3.1 2 1 0 2 2 2 1 RAM signalling pathway protein LRR_8 PF13855.1 ESA08981.1 - 1.3e-14 53.7 6.0 3.6e-08 33.0 0.2 3.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.2 ESA08981.1 - 3.2e-14 52.1 11.6 1.4e-05 24.5 0.1 5.7 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA08981.1 - 1.4e-09 36.6 1.0 0.087 12.8 0.0 6.9 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA08981.1 - 6.4e-05 22.5 0.6 81 4.1 0.0 6.4 5 0 0 5 5 5 0 Leucine rich repeat SLIDE PF09111.5 ESA08981.1 - 0.009 15.7 0.1 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 SLIDE LRR_6 PF13516.1 ESA08981.1 - 0.83 9.9 15.1 2.7 8.3 0.1 6.4 6 1 1 7 7 7 0 Leucine Rich repeat PH PF00169.24 ESA08982.1 - 0.00017 21.7 0.3 0.00017 21.7 0.2 2.2 2 1 0 2 2 2 1 PH domain RNA_POL_M_15KD PF02150.11 ESA08984.1 - 0.062 13.0 0.3 0.083 12.6 0.2 1.2 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit DUF2382 PF09557.5 ESA08985.1 - 0.33 10.8 9.0 0.49 10.3 1.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2382) PS_Dcarbxylase PF02666.10 ESA08987.1 - 1.4e-24 86.5 0.1 1.6e-24 86.3 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.1 ESA08987.1 - 0.24 11.1 1.4 0.56 9.9 1.0 1.8 1 1 0 1 1 1 0 Biotin-lipoyl like DUF2416 PF10315.4 ESA08988.1 - 4.4e-19 68.7 2.9 5.5e-19 68.4 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2416) Nyv1_N PF09426.5 ESA08989.1 - 0.0011 18.5 1.9 0.3 10.6 0.1 2.2 1 1 1 2 2 2 2 Vacuolar R-SNARE Nyv1 N terminal Peptidase_S3 PF00944.14 ESA08989.1 - 0.013 14.9 0.1 3.3 7.1 0.0 2.1 1 1 1 2 2 2 0 Alphavirus core protein PyrI_C PF02748.10 ESA08989.1 - 0.5 9.8 4.8 7.8 6.0 0.2 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.10 ESA08989.1 - 0.5 10.1 6.5 5.1 6.9 0.4 2.3 1 1 1 2 2 2 0 BED zinc finger PB1 PF00564.19 ESA08991.1 - 1.2e-13 50.5 0.0 1.6e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 PB1 domain MULE PF10551.4 ESA08991.1 - 0.073 13.2 0.2 0.14 12.3 0.0 1.5 1 1 1 2 2 2 0 MULE transposase domain FERM_N PF09379.5 ESA08991.1 - 0.086 12.9 0.1 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 FERM N-terminal domain DUF2192 PF09958.4 ESA08992.1 - 0.014 14.6 0.0 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) CutA1 PF03091.10 ESA08992.1 - 0.016 14.8 1.5 0.14 11.8 0.1 2.5 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein TryThrA_C PF12319.3 ESA08992.1 - 2.6 7.1 18.6 0.15 11.2 3.2 2.7 2 1 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal BTB PF00651.26 ESA08993.1 - 2.5e-07 30.6 0.1 6.8e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA08993.1 - 4.3e-07 29.7 0.2 2.1e-05 24.2 0.1 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch Sec34 PF04136.10 ESA08993.1 - 0.054 13.1 0.1 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Sec34-like family Kelch_3 PF13415.1 ESA08995.1 - 6.2e-05 23.0 4.8 1.6 8.9 0.1 5.2 3 1 1 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA08995.1 - 0.00011 21.9 6.1 0.15 11.8 0.1 3.9 4 0 0 4 4 4 3 Galactose oxidase, central domain PIF1 PF05970.9 ESA08997.1 - 3.3e-47 161.2 1.4 2.1e-24 86.1 0.1 2.0 1 1 1 2 2 2 2 PIF1-like helicase AAA_19 PF13245.1 ESA08997.1 - 0.037 13.7 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain ASFV_p27 PF06556.6 ESA08998.1 - 0.082 12.8 0.4 0.094 12.6 0.3 1.1 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus Ribosomal_S6e PF01092.14 ESA09000.1 - 8.8e-61 203.1 0.3 1.6e-60 202.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Prefoldin PF02996.12 ESA09001.1 - 9.3e-29 99.5 2.4 1e-28 99.3 1.7 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.15 ESA09001.1 - 0.0089 15.7 0.8 0.0089 15.7 0.5 1.8 2 0 0 2 2 2 1 Prefoldin subunit End3 PF12761.2 ESA09001.1 - 0.029 14.0 0.4 0.032 13.8 0.3 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 AAA_25 PF13481.1 ESA09002.1 - 1.2e-22 80.2 0.0 1.9e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 ESA09002.1 - 1e-12 47.6 0.0 1.9e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.1 ESA09002.1 - 2e-09 37.6 0.0 5.3e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Toprim_4 PF13662.1 ESA09002.1 - 1.3e-07 31.4 0.0 4.3e-06 26.6 0.0 2.4 2 0 0 2 2 2 1 Toprim domain DnaB_C PF03796.10 ESA09002.1 - 1.1e-05 24.5 0.0 2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.1 ESA09002.1 - 9.4e-05 22.4 0.0 0.00024 21.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Toprim_3 PF13362.1 ESA09002.1 - 0.00032 20.8 0.0 0.001 19.2 0.0 1.9 2 0 0 2 2 1 1 Toprim domain ABC_tran PF00005.22 ESA09002.1 - 0.00052 20.3 0.0 0.02 15.2 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_23 PF13476.1 ESA09002.1 - 0.0055 17.0 0.9 0.0055 17.0 0.6 2.5 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 ESA09002.1 - 0.0057 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 ESA09002.1 - 0.0087 16.8 0.5 0.045 14.5 0.2 2.5 2 1 0 2 2 2 1 AAA domain Toprim PF01751.17 ESA09002.1 - 0.014 15.3 0.0 0.055 13.4 0.0 2.0 1 0 0 1 1 1 0 Toprim domain ResIII PF04851.10 ESA09002.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_18 PF13238.1 ESA09002.1 - 0.019 15.2 0.5 0.15 12.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.1 ESA09002.1 - 0.021 14.7 0.1 0.069 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA09002.1 - 0.023 13.6 0.0 0.041 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.4 ESA09002.1 - 0.03 13.3 0.0 0.042 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 ESA09002.1 - 0.031 13.7 0.1 0.031 13.7 0.1 2.6 3 0 0 3 3 2 0 P-loop containing region of AAA domain Toprim_2 PF13155.1 ESA09002.1 - 0.033 14.4 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 1 0 Toprim-like AAA_28 PF13521.1 ESA09002.1 - 0.041 13.8 0.2 0.095 12.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain DUF258 PF03193.11 ESA09002.1 - 0.049 12.8 0.0 0.09 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA PF00004.24 ESA09002.1 - 0.061 13.5 0.0 0.45 10.7 0.0 2.5 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) DUF919 PF06034.6 ESA09002.1 - 0.063 12.8 1.3 0.16 11.6 0.0 2.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) MobB PF03205.9 ESA09002.1 - 0.07 12.8 0.7 0.73 9.5 0.1 2.6 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESA09002.1 - 0.17 11.6 0.1 0.36 10.6 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain TALPID3 PF15324.1 ESA09003.1 - 0.0052 14.2 1.4 0.0057 14.0 1.0 1.0 1 0 0 1 1 1 1 Hedgehog signalling target RasGAP PF00616.14 ESA09003.1 - 0.078 12.6 0.6 0.093 12.3 0.4 1.0 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase DUF2479 PF10651.4 ESA09004.1 - 0.011 15.2 3.1 0.037 13.5 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2479) Pkinase_Tyr PF07714.12 ESA09005.1 - 0.00012 21.2 0.0 0.00014 21.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09005.1 - 0.0012 18.0 0.0 0.0013 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain IBD PF10416.4 ESA09005.1 - 0.023 14.4 1.8 0.026 14.3 1.3 1.1 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD TLD PF07534.11 ESA09007.1 - 3.1e-10 40.2 0.3 9.1e-10 38.6 0.2 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA09007.1 - 0.0034 17.1 1.5 0.012 15.4 0.3 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch MOR2-PAG1_C PF14225.1 ESA09007.1 - 0.074 12.7 0.7 1.3 8.7 0.0 2.2 1 1 1 2 2 2 0 Cell morphogenesis C-terminal BTB PF00651.26 ESA09009.1 - 3.4e-13 49.5 1.3 7.7e-13 48.4 0.2 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA09009.1 - 2.2e-09 37.0 5.7 7.7e-07 28.9 0.2 4.1 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ESA09009.1 - 0.00032 20.6 3.0 0.048 13.6 0.0 3.6 2 1 1 3 3 3 1 TLD Skp1_POZ PF03931.10 ESA09009.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.7 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain DUF99 PF01949.11 ESA09010.1 - 0.073 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF99 GST_N_2 PF13409.1 ESA09012.1 - 5.2e-24 84.0 0.0 1.8e-21 75.8 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA09012.1 - 5.3e-15 55.0 0.0 6e-14 51.6 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESA09012.1 - 9.5e-08 31.9 0.0 1.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA09012.1 - 7.2e-07 29.6 0.0 1.5e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA09012.1 - 4.6e-06 26.7 0.1 0.0025 17.9 0.0 3.2 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Abhydrolase_6 PF12697.2 ESA09013.1 - 7.7e-14 52.1 0.0 1.7e-12 47.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA09013.1 - 1.8e-13 50.4 0.0 6.4e-13 48.6 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA09013.1 - 1.1e-07 31.6 0.1 0.0014 18.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF2305 PF10230.4 ESA09013.1 - 2e-05 24.1 0.0 0.025 14.0 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2305) Lipase_3 PF01764.20 ESA09013.1 - 0.00026 20.6 0.0 0.047 13.2 0.0 2.3 2 0 0 2 2 2 2 Lipase (class 3) Abhydrolase_2 PF02230.11 ESA09013.1 - 0.0021 17.5 0.0 0.098 12.0 0.0 2.1 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase UPF0227 PF05728.7 ESA09013.1 - 0.055 13.1 0.0 0.13 11.9 0.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) FSH1 PF03959.8 ESA09013.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) BTB PF00651.26 ESA09014.1 - 3e-21 75.5 0.5 4e-21 75.0 0.3 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.17 ESA09014.1 - 0.01 16.0 0.2 0.029 14.5 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain Urm1 PF09138.6 ESA09014.1 - 0.02 15.0 0.1 0.048 13.7 0.1 1.7 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Bcl-2 PF00452.14 ESA09014.1 - 0.033 14.3 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family LAGLIDADG_1 PF00961.14 ESA09014.1 - 0.3 11.6 2.4 0.44 11.1 1.4 1.5 1 1 0 1 1 1 0 LAGLIDADG endonuclease TLD PF07534.11 ESA09017.1 - 4.4e-14 52.6 1.2 1.1e-13 51.3 0.9 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA09017.1 - 5.6e-06 26.1 0.4 2.6e-05 23.9 0.2 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch CBM_20 PF00686.14 ESA09019.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Starch binding domain Miro PF08477.8 ESA09020.1 - 0.00025 21.5 0.1 0.012 16.1 0.0 3.3 2 0 0 2 2 2 1 Miro-like protein AAA_5 PF07728.9 ESA09020.1 - 0.00051 19.7 0.1 0.0056 16.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.7 ESA09020.1 - 0.0066 16.1 3.5 0.59 9.7 0.0 3.8 4 0 0 4 4 4 1 NACHT domain DUF258 PF03193.11 ESA09020.1 - 0.0066 15.6 0.1 0.38 9.9 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA09020.1 - 0.06 13.6 0.0 0.32 11.2 0.0 2.3 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.1 ESA09020.1 - 0.086 12.9 0.0 0.086 12.9 0.0 4.4 4 1 0 4 4 4 0 AAA domain Sel1 PF08238.7 ESA09022.1 - 2.3e-35 120.2 8.3 9.1e-09 35.6 0.0 5.5 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA09022.1 - 0.00042 20.5 5.3 0.14 12.7 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Peptidase_C25_C PF03785.9 ESA09022.1 - 0.0079 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C25, C terminal ig-like domain MIT PF04212.13 ESA09022.1 - 0.16 11.8 5.8 17 5.4 0.1 3.7 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA09022.1 - 3.1 7.5 11.9 3.1 7.5 1.7 3.7 1 1 4 5 5 5 0 TPR repeat SpoOE-like PF09388.5 ESA09023.1 - 0.015 14.7 0.4 0.038 13.5 0.3 1.7 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein MamL-1 PF09596.5 ESA09023.1 - 0.03 14.1 0.1 0.06 13.1 0.1 1.4 1 0 0 1 1 1 0 MamL-1 domain DUF2937 PF11157.3 ESA09023.1 - 0.14 11.5 0.1 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) CHB_HEX_C PF03174.8 ESA09024.1 - 0.54 10.1 4.5 0.21 11.4 0.2 2.2 1 1 1 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Transferase PF02458.10 ESA09026.1 - 0.0028 16.1 0.0 0.0031 16.0 0.0 1.0 1 0 0 1 1 1 1 Transferase family DUF869 PF05911.6 ESA09027.1 - 0.015 13.5 1.6 0.021 13.0 1.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) XhlA PF10779.4 ESA09027.1 - 8.3 6.4 7.9 2.6 8.0 1.2 2.4 2 1 1 3 3 3 0 Haemolysin XhlA Asp_protease_2 PF13650.1 ESA09028.1 - 0.0089 16.5 0.0 0.02 15.3 0.0 1.7 1 1 0 1 1 1 1 Aspartyl protease U-box PF04564.10 ESA09029.1 - 1.7e-06 27.9 0.0 4.8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 U-box domain Myb_DNA-binding PF00249.26 ESA09029.1 - 6.1e-05 22.9 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Pyridox_oxase_2 PF12766.2 ESA09029.1 - 0.043 14.1 2.4 0.059 13.6 0.2 2.3 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase CDP-OH_P_transf PF01066.16 ESA09030.1 - 5.1e-14 52.4 4.7 5.1e-14 52.4 3.3 1.7 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Arc PF03869.9 ESA09030.1 - 0.021 14.4 0.2 0.039 13.5 0.2 1.3 1 0 0 1 1 1 0 Arc-like DNA binding domain Velvet PF11754.3 ESA09031.1 - 3.2e-33 115.0 0.1 6e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Velvet factor Nucleo_P87 PF07267.6 ESA09031.1 - 1.7 7.2 5.4 1.9 7.0 3.7 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 G10 PF01125.12 ESA09032.1 - 0.39 10.2 1.3 17 4.9 0.0 2.8 2 1 1 3 3 3 0 G10 protein O-FucT PF10250.4 ESA09033.1 - 7.2e-13 48.3 2.5 3.5e-12 46.1 1.8 1.9 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase PIF1 PF05970.9 ESA09034.1 - 0.00012 21.1 0.1 0.00022 20.3 0.0 1.4 1 1 0 1 1 1 1 PIF1-like helicase RNA_pol_Rpb1_1 PF04997.7 ESA09034.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 DUF1251 PF06856.6 ESA09039.1 - 0.05 13.1 0.1 0.28 10.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1251) Sod_Cu PF00080.15 ESA09042.1 - 1.6e-05 25.0 0.0 2.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Ras PF00071.17 ESA09043.1 - 1.3e-38 131.9 0.0 1.4e-38 131.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA09043.1 - 1.7e-12 47.8 0.0 2e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA09043.1 - 1.4e-06 27.6 0.0 1.6e-06 27.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA09043.1 - 0.0018 17.4 0.0 0.002 17.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESA09043.1 - 0.03 13.5 0.0 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit F-box-like PF12937.2 ESA09044.1 - 0.0031 17.2 0.0 0.016 14.8 0.0 2.2 1 0 0 1 1 1 1 F-box-like Mitochondr_Som1 PF11093.3 ESA09044.1 - 0.048 13.4 0.1 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial export protein Som1 Glyco_hydro_35 PF01301.14 ESA09045.1 - 1.9e-65 221.3 0.3 6.8e-48 163.6 0.0 2.4 1 1 1 2 2 2 2 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.1 ESA09045.1 - 2e-10 40.9 0.2 0.00026 21.2 0.0 2.6 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain Cellulase PF00150.13 ESA09045.1 - 0.00022 20.5 0.0 0.00042 19.6 0.0 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_20 PF00686.14 ESA09046.1 - 4e-05 23.1 0.1 9.3e-05 21.9 0.1 1.7 1 0 0 1 1 1 1 Starch binding domain N_NLPC_P60 PF12912.2 ESA09046.1 - 0.95 9.5 4.4 0.25 11.4 0.3 2.0 2 0 0 2 2 2 0 NLPC_P60 stabilising domain, N term DUF898 PF05987.8 ESA09047.1 - 2.3 7.0 12.8 3.1 6.6 2.8 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF962 PF06127.6 ESA09048.1 - 0.046 13.6 5.6 0.11 12.4 0.5 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF962) 5TM-5TMR_LYT PF07694.7 ESA09048.1 - 0.44 9.8 14.6 0.071 12.4 7.2 1.8 2 0 0 2 2 2 0 5TMR of 5TMR-LYT MMgT PF10270.4 ESA09048.1 - 4.1 7.8 7.8 1 9.8 1.5 2.5 2 1 0 2 2 2 0 Membrane magnesium transporter Pkinase_Tyr PF07714.12 ESA09049.1 - 1.9e-34 118.9 0.2 1.9e-34 118.9 0.1 2.5 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09049.1 - 1.9e-33 115.7 0.2 1.9e-33 115.7 0.1 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09050.1 - 1.4e-10 40.6 0.0 1.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09050.1 - 5.4e-08 32.2 0.0 7.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA09051.1 - 8.1e-32 108.9 2.3 1.9e-07 31.5 0.0 5.8 6 0 0 6 6 6 5 Sel1 repeat GSH-S_N PF02951.9 ESA09051.1 - 0.0014 18.4 0.0 11 5.8 0.0 3.0 3 0 0 3 3 3 2 Prokaryotic glutathione synthetase, N-terminal domain TPR_11 PF13414.1 ESA09051.1 - 0.016 14.8 8.4 0.068 12.8 0.4 3.6 2 1 2 4 4 4 0 TPR repeat DUF2675 PF11247.3 ESA09051.1 - 0.042 13.9 0.1 2.7 8.1 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2675) End_N_terminal PF12218.3 ESA09051.1 - 0.055 12.9 0.4 2 7.9 0.1 2.4 2 1 0 2 2 2 0 N terminal extension of bacteriophage endosialidase Ribosomal_L32e PF01655.13 ESA09051.1 - 0.058 13.4 0.1 7.7 6.6 0.0 2.8 3 0 0 3 3 3 0 Ribosomal protein L32 Antiterm PF03589.8 ESA09051.1 - 0.11 12.6 0.8 0.65 10.1 0.0 2.5 3 1 0 3 3 3 0 Antitermination protein zf-RING_2 PF13639.1 ESA09052.1 - 0.0032 17.2 0.7 0.007 16.1 0.0 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 ESA09052.1 - 0.023 14.4 0.0 0.082 12.6 0.0 2.0 1 0 0 1 1 1 0 RING-type zinc-finger Syntaxin PF00804.20 ESA09052.1 - 0.13 12.4 4.8 0.72 10.0 3.3 2.3 1 1 0 1 1 1 0 Syntaxin Reprolysin_5 PF13688.1 ESA09052.1 - 0.14 12.0 0.2 0.73 9.7 0.1 2.1 1 1 1 2 2 2 0 Metallo-peptidase family M12 zf-C3HC4_3 PF13920.1 ESA09052.1 - 0.5 10.0 5.8 0.077 12.6 0.5 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF2392 PF10288.4 ESA09052.1 - 1.6 9.0 5.0 0.58 10.5 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2392) zf-C2H2_2 PF12756.2 ESA09054.1 - 4.4e-35 119.8 18.1 9.4e-24 83.4 1.0 3.5 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 ESA09054.1 - 1.5e-05 24.9 0.8 1.5e-05 24.9 0.6 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESA09054.1 - 0.00041 20.5 1.7 0.00041 20.5 1.1 4.9 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-met PF12874.2 ESA09054.1 - 0.0049 17.0 0.6 0.0049 17.0 0.4 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 ESA09054.1 - 0.0062 16.7 1.0 0.0062 16.7 0.7 5.1 5 0 0 5 5 5 1 C2H2-type zinc finger Transpos_assoc PF13963.1 ESA09054.1 - 0.07 13.1 0.2 0.07 13.1 0.2 3.2 4 0 0 4 4 4 0 Transposase-associated domain PyrI_C PF02748.10 ESA09054.1 - 0.2 11.1 0.0 0.2 11.1 0.0 4.2 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.7 ESA09054.1 - 0.38 10.9 14.5 6.8 6.9 0.5 4.8 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding Baculo_11_kDa PF06143.6 ESA09056.1 - 0.048 13.0 1.6 0.13 11.6 1.1 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF912 PF06024.7 ESA09056.1 - 0.16 12.0 5.0 0.16 12.0 0.7 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Nucleoplasmin PF03066.10 ESA09056.1 - 0.97 8.9 5.4 1.5 8.3 3.7 1.2 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 ESA09056.1 - 1.3 9.3 8.8 0.22 11.8 3.2 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tmemb_9 PF05434.6 ESA09056.1 - 2.3 7.9 4.3 4.5 7.0 1.0 2.2 2 0 0 2 2 2 0 TMEM9 DUF3753 PF12575.3 ESA09056.1 - 2.6 7.9 11.3 0.29 10.9 2.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) DUF3278 PF11683.3 ESA09056.1 - 2.8 7.9 11.0 0.13 12.2 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) DUF1510 PF07423.6 ESA09056.1 - 5.6 6.2 8.8 1.6 8.0 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) Ricin_B_lectin PF00652.17 ESA09057.1 - 4e-10 39.7 0.1 2.2e-05 24.4 0.0 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 ESA09057.1 - 2e-05 24.9 0.3 0.12 12.7 0.0 2.2 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like DUF4320 PF14208.1 ESA09057.1 - 0.083 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) Imm3 PF14425.1 ESA09058.1 - 0.16 11.9 3.7 4.9 7.1 0.0 3.2 3 0 0 3 3 3 0 Immunity protein Imm3 Epsilon_antitox PF08998.6 ESA09058.1 - 0.28 11.1 3.4 0.94 9.4 0.3 2.6 3 0 0 3 3 3 0 Bacterial epsilon antitoxin PCI_Csn8 PF10075.4 ESA09060.1 - 3.9e-34 117.4 0.0 6.1e-34 116.8 0.0 1.4 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 ESA09060.1 - 4.1e-10 39.5 0.0 5.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI PF01399.22 ESA09060.1 - 0.0023 18.2 0.2 0.0053 17.0 0.0 1.7 2 1 0 2 2 2 1 PCI domain Bromodomain PF00439.20 ESA09060.1 - 0.12 12.2 0.1 0.63 10.0 0.0 2.2 2 1 0 2 2 2 0 Bromodomain DUF4175 PF13779.1 ESA09063.1 - 6.1 4.4 8.5 6.5 4.3 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Pkinase_Tyr PF07714.12 ESA09065.1 - 8.6e-06 25.0 0.0 1.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09065.1 - 0.00084 18.5 0.0 0.001 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Dimer_Tnp_hAT PF05699.9 ESA09066.1 - 1.3e-15 56.7 0.1 2.6e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA09066.1 - 0.00037 20.0 0.5 0.0026 17.2 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF 659) RNA12 PF10443.4 ESA09069.1 - 0.093 11.2 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein Ribosomal_L14e PF01929.12 ESA09069.1 - 0.099 13.0 0.2 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L14 F-box-like PF12937.2 ESA09070.1 - 0.026 14.2 3.9 0.084 12.6 0.9 2.9 3 0 0 3 3 3 0 F-box-like AIG1 PF04548.11 ESA09071.1 - 1.6e-20 73.1 1.6 1.6e-20 73.1 1.1 2.1 1 1 1 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ESA09071.1 - 2e-09 37.4 0.8 5.3e-09 36.0 0.2 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA09071.1 - 0.0075 15.4 0.1 0.026 13.7 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESA09071.1 - 0.021 14.7 1.4 2.1 8.2 0.0 2.5 2 1 1 3 3 3 0 AAA ATPase domain T2SE PF00437.15 ESA09071.1 - 0.064 12.1 0.1 0.16 10.8 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Sec2p PF06428.6 ESA09071.1 - 0.14 11.9 15.8 0.1 12.4 7.1 2.4 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p ABC_tran PF00005.22 ESA09071.1 - 0.76 10.0 9.9 11 6.3 6.8 2.6 1 1 0 1 1 1 0 ABC transporter DUF972 PF06156.8 ESA09071.1 - 2.7 8.3 11.2 9.4 6.6 5.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DUF1640 PF07798.6 ESA09071.1 - 4.3 7.3 12.4 0.65 10.0 5.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) DUF3987 PF13148.1 ESA09071.1 - 9 4.7 10.3 61 2.0 7.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) RNA_binding PF01877.12 ESA09072.1 - 0.0074 16.2 0.3 0.0094 15.9 0.2 1.1 1 0 0 1 1 1 1 RNA binding NuA4 PF09340.5 ESA09072.1 - 0.12 12.0 0.9 0.18 11.4 0.2 1.6 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 HNH PF01844.18 ESA09073.1 - 0.15 11.9 0.7 5.4 6.9 0.0 2.3 2 0 0 2 2 2 0 HNH endonuclease Pkinase PF00069.20 ESA09074.1 - 1.3e-06 27.7 0.0 1.5e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09074.1 - 5.9e-05 22.2 0.0 6.3e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA09074.1 - 0.036 13.8 0.0 0.053 13.2 0.0 1.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA09074.1 - 0.085 11.9 0.0 0.099 11.6 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tmemb_14 PF03647.8 ESA09075.1 - 4.3e-25 87.9 14.7 4.8e-25 87.7 10.2 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF3353 PF11833.3 ESA09075.1 - 0.013 14.9 2.6 0.017 14.5 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3353) PMT_2 PF13231.1 ESA09075.1 - 0.32 10.8 4.3 0.39 10.6 3.0 1.1 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2416 PF10315.4 ESA09075.1 - 0.35 11.1 2.7 0.51 10.6 1.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2416) O-antigen_lig PF13425.1 ESA09075.1 - 1.2 9.0 9.8 1.9 8.4 6.8 1.4 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Prominin PF05478.6 ESA09076.1 - 0.11 9.9 0.1 0.1 10.1 0.1 1.0 1 0 0 1 1 1 0 Prominin SH3_2 PF07653.12 ESA09077.1 - 0.076 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain UPF0147 PF03685.8 ESA09077.1 - 0.11 12.4 0.1 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) E2F_TDP PF02319.15 ESA09077.1 - 0.23 11.0 1.0 0.88 9.1 0.2 2.1 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain SNARE_assoc PF09335.6 ESA09078.1 - 1.3e-19 70.6 3.8 1.3e-19 70.6 2.6 2.4 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF2561 PF10812.3 ESA09078.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) Rad21_Rec8_N PF04825.8 ESA09079.1 - 1.1e-25 89.7 0.0 2.6e-25 88.5 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Pkinase PF00069.20 ESA09080.1 - 6.7e-45 153.2 0.1 6.7e-45 153.2 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09080.1 - 4.6e-43 147.1 0.0 7.1e-43 146.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase BCS1_N PF08740.6 ESA09080.1 - 0.015 14.9 0.0 0.3 10.6 0.0 2.3 2 0 0 2 2 2 0 BCS1 N terminal DUF1034 PF06280.7 ESA09082.1 - 0.075 13.4 0.0 0.089 13.2 0.0 1.1 1 0 0 1 1 1 0 Fn3-like domain (DUF1034) Pkinase_Tyr PF07714.12 ESA09084.1 - 1e-07 31.3 0.0 1.2e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09084.1 - 2.7e-06 26.7 0.1 7e-06 25.3 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain DNA_topoisoIV PF00521.15 ESA09086.1 - 0.079 11.7 0.4 0.082 11.7 0.3 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A ABC1 PF03109.11 ESA09089.1 - 2.6e-31 108.0 0.0 4.3e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Phage_rep_org_N PF09681.5 ESA09089.1 - 0.21 11.1 4.3 0.53 9.8 0.0 3.5 4 2 0 4 4 4 0 N-terminal phage replisome organiser (Phage_rep_org_N) Cornifin PF02389.10 ESA09090.1 - 0.0076 16.0 8.1 0.012 15.3 5.6 1.3 1 0 0 1 1 1 1 Cornifin (SPRR) family Arrestin_C PF02752.17 ESA09091.1 - 4.3e-08 33.3 4.0 4.1e-07 30.1 1.4 2.4 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ESA09091.1 - 9.7e-05 22.2 5.0 0.00011 22.0 0.0 3.0 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_N PF00339.24 ESA09092.1 - 4.6e-05 23.2 0.1 0.00021 21.1 0.1 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF4536 PF15055.1 ESA09092.1 - 0.0056 16.7 2.5 0.0056 16.7 1.7 1.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4536) Fasciclin PF02469.17 ESA09093.1 - 5e-82 272.2 0.4 3.3e-19 69.1 0.0 6.0 5 1 0 5 5 5 5 Fasciclin domain Pyr_redox_2 PF07992.9 ESA09095.1 - 7.6e-10 39.0 0.9 1.2e-08 35.0 0.6 2.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESA09095.1 - 4.4e-07 30.1 0.2 0.31 11.0 0.1 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESA09095.1 - 3.3e-05 24.2 1.5 0.28 11.6 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 ESA09095.1 - 0.0013 17.4 0.8 0.32 9.5 0.0 2.6 3 0 0 3 3 3 2 Tryptophan halogenase NAD_binding_9 PF13454.1 ESA09095.1 - 0.0044 16.7 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.19 ESA09095.1 - 0.0052 15.7 0.1 2.3 7.0 0.0 3.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase GLF PF03275.8 ESA09095.1 - 0.011 15.2 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 UDP-galactopyranose mutase Lycopene_cycl PF05834.7 ESA09095.1 - 0.014 14.3 0.0 2.4 6.9 0.0 2.2 1 1 1 2 2 2 0 Lycopene cyclase protein Tet_JBP PF12851.2 ESA09096.1 - 0.071 12.3 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily HMG_box PF00505.14 ESA09099.1 - 0.055 13.7 0.3 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 HMG (high mobility group) box DUF4134 PF13572.1 ESA09100.1 - 0.17 12.0 0.0 3.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) SH3BGR PF04908.10 ESA09100.1 - 1.2 9.1 3.4 28 4.7 0.2 3.4 1 1 3 4 4 4 0 SH3-binding, glutamic acid-rich protein DUF551 PF04448.7 ESA09100.1 - 1.7 9.4 7.6 0.57 10.9 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF551) Ribosomal_S28e PF01200.13 ESA09102.1 - 1e-34 118.0 1.7 1.1e-34 117.9 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e SH2_2 PF14633.1 ESA09103.1 - 2.9e-36 124.6 2.4 3.3e-36 124.4 0.0 2.3 2 1 0 2 2 2 1 SH2 domain YqgF PF14639.1 ESA09103.1 - 4.5e-24 84.7 2.5 2.2e-23 82.4 0.0 3.1 3 0 0 3 3 3 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.1 ESA09103.1 - 4.3e-23 81.4 0.0 3.4e-22 78.5 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif SPT6_acidic PF14632.1 ESA09103.1 - 2.6e-19 69.1 21.1 2.6e-19 69.1 14.6 2.6 2 0 0 2 2 2 1 Acidic N-terminal SPT6 HTH_44 PF14641.1 ESA09103.1 - 5.5e-13 48.9 2.5 3.6e-12 46.3 0.4 3.3 3 0 0 3 3 3 1 Helix-turn-helix DNA-binding domain of SPT6 SH2 PF00017.19 ESA09103.1 - 3.6e-05 23.4 0.0 0.00017 21.3 0.0 2.3 2 0 0 2 2 2 1 SH2 domain S1 PF00575.18 ESA09103.1 - 0.0013 18.8 0.1 0.0013 18.8 0.0 2.0 2 0 0 2 2 2 1 S1 RNA binding domain DLD PF14878.1 ESA09103.1 - 0.0021 18.1 17.1 0.0061 16.6 0.2 4.4 2 1 1 3 3 3 2 Death-like domain of SPT6 Flagellin_IN PF07196.8 ESA09103.1 - 0.026 14.4 0.6 0.085 12.8 0.4 1.8 1 0 0 1 1 1 0 Flagellin hook IN motif Asp_protease_2 PF13650.1 ESA09104.1 - 0.0009 19.6 0.0 0.0012 19.2 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA09104.1 - 0.074 12.9 0.0 0.27 11.1 0.0 2.0 1 1 0 1 1 1 0 Retroviral aspartyl protease DUF1057 PF06342.7 ESA09105.1 - 0.016 14.0 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) SWIRM PF04433.12 ESA09106.1 - 1.3e-11 44.4 0.4 2.6e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 SWIRM domain V-SNARE PF05008.10 ESA09107.1 - 1.5e-07 31.4 1.7 1.5e-07 31.4 1.2 1.6 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus MbeB_N PF04837.7 ESA09107.1 - 0.11 12.6 2.4 0.99 9.5 0.3 2.3 2 0 0 2 2 2 0 MbeB-like, N-term conserved region HR1 PF02185.11 ESA09107.1 - 0.16 11.7 1.8 0.21 11.3 0.7 1.6 2 0 0 2 2 2 0 Hr1 repeat Baculo_PEP_C PF04513.7 ESA09107.1 - 0.19 11.5 1.0 2.5 7.9 0.7 2.0 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus V-SNARE_C PF12352.3 ESA09107.1 - 0.23 11.5 5.2 0.42 10.7 0.1 2.5 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus RNase_P_Rpp14 PF01900.14 ESA09108.1 - 0.00027 20.8 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Rpp14/Pop5 family CTP_transf_1 PF01148.15 ESA09109.1 - 1.3e-83 280.6 28.0 1.6e-83 280.3 19.4 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family E1_DerP2_DerF2 PF02221.10 ESA09110.1 - 1.4e-21 77.1 0.0 1.8e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 ESA09110.1 - 0.001 19.1 0.0 0.0022 17.9 0.0 1.7 1 1 0 1 1 1 1 ML-like domain DUF4098 PF13345.1 ESA09111.1 - 0.0096 15.8 35.8 0.041 13.8 5.1 4.5 2 1 3 5 5 5 4 Domain of unknown function (DUF4098) TFIIA PF03153.8 ESA09112.1 - 0.54 10.0 10.0 0.61 9.9 6.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Prefoldin_2 PF01920.15 ESA09113.1 - 0.00038 20.1 11.2 0.00083 19.0 7.8 1.5 1 1 0 1 1 1 1 Prefoldin subunit Spore_IV_A PF09547.5 ESA09113.1 - 0.071 11.7 3.1 0.072 11.7 2.1 1.0 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Bromodomain PF00439.20 ESA09113.1 - 0.28 11.1 2.3 0.61 10.0 0.1 2.0 1 1 1 2 2 2 0 Bromodomain DUF2051 PF09738.4 ESA09113.1 - 0.68 9.1 9.9 0.73 9.0 6.8 1.0 1 0 0 1 1 1 0 Double stranded RNA binding protein (DUF2051) YgaB PF14182.1 ESA09113.1 - 3.3 8.0 7.8 1.3 9.3 1.8 2.2 1 1 1 2 2 2 0 YgaB-like protein DivIC PF04977.10 ESA09113.1 - 5.1 6.6 11.3 6.1 6.4 0.4 2.1 1 1 1 2 2 2 0 Septum formation initiator BTB PF00651.26 ESA09115.1 - 6.5e-11 42.2 0.0 9.4e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Med31 PF05669.7 ESA09117.1 - 0.069 12.8 4.6 0.13 12.0 3.2 1.5 1 1 0 1 1 1 0 SOH1 Conotoxin PF02950.12 ESA09118.1 - 0.0077 17.0 4.3 4.2 8.2 0.0 2.3 2 0 0 2 2 2 2 Conotoxin Chromo_shadow PF01393.14 ESA09118.1 - 0.087 12.6 0.1 11 5.9 0.0 3.2 1 1 2 3 3 3 0 Chromo shadow domain pKID PF02173.12 ESA09118.1 - 0.89 8.8 5.2 8.1 5.7 0.1 3.2 2 1 2 4 4 4 0 pKID domain DUF4642 PF15484.1 ESA09118.1 - 1.1 9.2 3.9 15 5.5 0.3 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4642) COBRA1 PF06209.8 ESA09120.1 - 5.3e-19 68.1 0.4 2e-18 66.2 0.3 1.7 1 1 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) RE_HaeII PF09554.5 ESA09120.1 - 0.0053 15.7 0.6 0.014 14.3 0.2 1.7 2 0 0 2 2 2 1 HaeII restriction endonuclease Pkinase_Tyr PF07714.12 ESA09121.1 - 2.4e-28 98.9 0.0 3.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09121.1 - 1.6e-25 89.7 0.1 2e-25 89.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA09121.1 - 0.041 12.9 0.0 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family BTB PF00651.26 ESA09122.1 - 0.00031 20.7 0.0 0.00046 20.1 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3518 PF12031.3 ESA09124.1 - 5.6e-08 31.9 0.1 2.9e-05 23.0 0.0 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF3518) TP2 PF01254.13 ESA09125.1 - 1 9.7 13.9 1.4 9.2 9.7 1.3 1 0 0 1 1 1 0 Nuclear transition protein 2 SUR7 PF06687.7 ESA09126.1 - 0.016 14.7 0.4 0.017 14.6 0.2 1.1 1 0 0 1 1 1 0 SUR7/PalI family ADH_zinc_N PF00107.21 ESA09129.1 - 2.1e-21 75.8 0.0 5.2e-21 74.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA09129.1 - 2.5e-06 28.4 0.0 3e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.3 ESA09129.1 - 0.029 13.5 0.0 0.43 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2855) Pex14_N PF04695.8 ESA09129.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase_Tyr PF07714.12 ESA09131.1 - 2.9e-06 26.5 0.0 4.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09131.1 - 0.0021 17.2 0.2 0.0084 15.2 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain p450 PF00067.17 ESA09132.1 - 1.7e-18 66.3 0.0 1.9e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kelch_4 PF13418.1 ESA09133.1 - 2.6e-22 78.2 13.6 3.6e-09 36.2 0.1 6.3 4 1 2 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA09133.1 - 2.5e-17 62.3 3.9 1.8e-06 27.7 0.0 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.1 ESA09133.1 - 7.7e-16 57.7 0.8 5.4e-06 26.4 0.0 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09133.1 - 2.2e-11 43.3 9.3 0.0008 19.4 0.1 5.2 3 1 2 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA09133.1 - 1e-10 40.9 10.7 0.00068 19.1 0.1 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA09133.1 - 1.1e-09 37.6 7.3 0.0029 17.3 0.0 5.5 5 0 0 5 5 5 3 Kelch motif DUF1694 PF07997.6 ESA09134.1 - 0.11 12.3 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) CBM_20 PF00686.14 ESA09135.1 - 0.07 12.7 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Starch binding domain Vac7 PF12751.2 ESA09137.1 - 1.1e-15 57.3 9.3 2.6e-08 33.1 0.1 3.2 2 1 1 3 3 3 3 Vacuolar segregation subunit 7 UFD1 PF03152.9 ESA09138.1 - 1.1e-41 141.8 0.0 2.3e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.12 ESA09138.1 - 0.067 12.8 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 Myb_DNA-binding PF00249.26 ESA09139.1 - 1.7e-09 37.5 0.1 6.1e-09 35.7 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA09139.1 - 3.4e-05 23.8 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain S-layer PF07752.6 ESA09140.1 - 0.022 13.9 2.1 0.027 13.6 1.5 1.0 1 0 0 1 1 1 0 S-layer protein zf-CSL PF05207.8 ESA09141.1 - 0.12 11.9 9.3 2.3 7.7 3.9 2.7 2 1 0 2 2 2 0 CSL zinc finger Arc_trans_TRASH PF08394.5 ESA09141.1 - 0.38 10.9 6.3 0.42 10.8 0.7 2.8 2 0 0 2 2 2 0 Archaeal TRASH domain RRM_1 PF00076.17 ESA09142.1 - 7.9e-11 41.4 0.0 0.00035 20.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA09142.1 - 6.8e-07 29.1 0.0 0.045 13.7 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA09142.1 - 0.00088 19.0 0.0 0.31 10.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Toxin-deaminase PF14424.1 ESA09143.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Copine PF07002.11 ESA09144.1 - 6.9e-51 171.8 0.0 1e-50 171.2 0.0 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.25 ESA09144.1 - 1.4e-10 40.8 0.4 2.9e-06 27.0 0.1 2.5 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.4 ESA09144.1 - 1.1e-07 31.9 0.0 2.6e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 vWA found in TerF C terminus DUF3409 PF11889.3 ESA09147.1 - 0.0049 16.5 2.0 18 5.1 0.1 3.9 4 0 0 4 4 4 2 Domain of unknown function (DUF3409) DZR PF12773.2 ESA09147.1 - 0.88 9.4 14.5 0.19 11.5 0.5 3.0 3 0 0 3 3 3 0 Double zinc ribbon DUF1154 PF06631.6 ESA09147.1 - 3.2 7.4 4.9 25 4.6 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1154) DUF2535 PF10751.4 ESA09147.1 - 3.4 7.8 6.7 0.66 10.1 0.4 2.9 2 2 1 4 4 4 0 Protein of unknown function (DUF2535) PCI_Csn8 PF10075.4 ESA09148.1 - 0.086 12.6 0.1 0.22 11.3 0.1 1.8 2 0 0 2 2 2 0 COP9 signalosome, subunit CSN8 Sel1 PF08238.7 ESA09149.1 - 1.7e-90 295.4 26.5 5.8e-12 45.8 0.6 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_16 PF13432.1 ESA09149.1 - 7.9e-05 23.2 0.0 10 6.9 0.1 4.6 1 1 5 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA09149.1 - 0.0024 18.1 10.4 3.1 8.4 0.1 6.6 8 0 0 8 8 8 1 Tetratricopeptide repeat NAGLU_N PF12971.2 ESA09149.1 - 0.078 12.6 0.0 24 4.6 0.0 4.2 5 0 0 5 5 5 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain SLT PF01464.15 ESA09149.1 - 0.94 8.9 26.0 0.62 9.5 0.1 5.8 3 2 4 7 7 7 0 Transglycosylase SLT domain MIR PF02815.14 ESA09150.1 - 0.00048 19.7 0.1 0.00098 18.7 0.1 1.5 1 1 0 1 1 1 1 MIR domain Arteri_env PF01606.11 ESA09150.1 - 0.012 15.3 0.2 0.013 15.1 0.1 1.2 1 0 0 1 1 1 0 Arterivirus envelope protein Botulinum_HA-17 PF05588.6 ESA09150.1 - 0.053 13.4 0.1 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Clostridium botulinum HA-17 protein Peptidase_S8 PF00082.17 ESA09151.1 - 3.8e-54 183.7 0.6 7e-54 182.8 0.0 1.7 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 ESA09151.1 - 1.8e-29 101.3 0.7 3.9e-29 100.2 0.5 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF2914 PF11141.3 ESA09151.1 - 0.017 14.5 0.3 0.044 13.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) FHA PF00498.21 ESA09152.1 - 1.6e-17 63.3 0.0 2.9e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain WSC PF01822.14 ESA09154.1 - 4.1e-25 87.5 28.7 5.3e-18 64.7 8.9 2.6 3 0 0 3 3 3 2 WSC domain Sel1 PF08238.7 ESA09155.1 - 7.3e-49 163.1 21.2 2e-13 50.5 0.9 4.9 5 0 0 5 5 5 4 Sel1 repeat IL22 PF14565.1 ESA09155.1 - 2.9e-05 24.1 0.7 0.053 13.5 0.0 3.1 1 1 3 4 4 4 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Surfac_D-trimer PF09006.6 ESA09155.1 - 0.00052 19.6 0.1 17 5.2 0.0 4.0 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA09155.1 - 0.00058 19.8 12.9 1.2 9.5 0.4 5.1 3 3 1 4 4 4 2 Tetratricopeptide repeat HTH_16 PF12645.2 ESA09155.1 - 0.00059 19.7 3.2 7.8 6.5 0.0 4.1 4 0 0 4 4 4 1 Helix-turn-helix domain MIT PF04212.13 ESA09155.1 - 0.0039 17.0 12.7 2.5 8.0 0.2 4.1 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA09155.1 - 0.0067 16.3 14.4 0.32 10.9 1.7 3.9 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA09155.1 - 0.022 14.3 22.2 0.98 9.1 4.4 4.1 1 1 3 4 4 4 0 TPR repeat Flu_M1_C PF08289.6 ESA09155.1 - 0.065 13.2 0.0 18 5.4 0.0 3.2 1 1 2 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain BURP PF03181.10 ESA09155.1 - 0.13 11.4 0.1 2.1 7.4 0.0 2.5 1 1 2 3 3 3 0 BURP domain DIL PF01843.14 ESA09155.1 - 0.3 10.9 4.0 11 5.9 0.1 3.1 1 1 2 3 3 3 0 DIL domain MKT1_C PF12246.3 ESA09155.1 - 0.31 10.0 4.4 4.6 6.1 1.4 2.9 1 1 1 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication TPR_10 PF13374.1 ESA09155.1 - 0.35 10.8 15.7 9.6 6.2 0.2 5.3 7 0 0 7 7 7 0 Tetratricopeptide repeat DCP1 PF06058.8 ESA09155.1 - 0.4 10.7 2.2 21 5.1 0.1 3.1 1 1 3 4 4 4 0 Dcp1-like decapping family WHIM2 PF15613.1 ESA09155.1 - 0.44 10.5 2.2 72 3.5 0.0 3.8 4 0 0 4 4 4 0 WSTF, HB1, Itc1p, MBD9 motif 2 Toxin_51 PF15531.1 ESA09155.1 - 1.1 9.1 6.3 20 5.0 0.1 3.0 1 1 2 3 3 3 0 Putative toxin 51 Rapamycin_bind PF08771.6 ESA09155.1 - 7.3 6.7 7.8 45 4.2 0.1 3.6 2 2 2 4 4 4 0 Rapamycin binding domain NOB1_Zn_bind PF08772.6 ESA09156.1 - 0.00026 20.7 3.9 0.13 12.1 0.1 2.7 2 0 0 2 2 2 2 Nin one binding (NOB1) Zn-ribbon like Pkinase_Tyr PF07714.12 ESA09156.1 - 0.014 14.4 0.1 0.048 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase PYST-C1 PF09690.5 ESA09156.1 - 0.07 12.7 9.4 2.8 7.6 2.2 3.2 2 1 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) zf-C3HC4 PF00097.20 ESA09156.1 - 0.24 11.0 15.3 0.91 9.2 3.3 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA09156.1 - 1.2 9.1 15.2 5.6 7.0 3.0 3.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-DBF PF07535.7 ESA09156.1 - 2 8.1 18.9 5.2 6.8 1.9 3.5 3 1 0 3 3 3 0 DBF zinc finger zf-RING_5 PF14634.1 ESA09156.1 - 5.5 6.8 14.4 1 9.1 2.3 2.5 2 0 0 2 2 2 0 zinc-RING finger domain Kelch_3 PF13415.1 ESA09157.1 - 1.6e-19 69.5 9.7 0.00045 20.2 0.0 5.9 5 2 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA09157.1 - 5.8e-17 61.2 13.8 0.00055 19.6 0.4 6.1 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA09157.1 - 2.7e-13 49.5 10.1 0.003 17.4 0.1 5.9 5 1 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 ESA09157.1 - 6.1e-12 45.1 9.6 0.0093 16.1 0.1 5.8 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA09157.1 - 0.17 11.4 12.2 0.2 11.2 0.2 4.1 4 0 0 4 4 4 0 Kelch motif DUF2937 PF11157.3 ESA09159.1 - 0.03 13.6 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) EVC2_like PF12297.3 ESA09159.1 - 0.081 11.5 0.1 0.083 11.5 0.1 1.0 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DNA_gyraseB PF00204.20 ESA09160.1 - 0.014 14.6 0.3 0.5 9.5 0.0 2.5 2 1 0 2 2 2 0 DNA gyrase B HMG_box PF00505.14 ESA09162.1 - 2.4e-07 30.8 1.3 4.7e-07 29.9 0.9 1.5 1 1 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA09162.1 - 0.033 13.5 0.5 0.031 13.5 0.3 1.1 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 NAD_binding_10 PF13460.1 ESA09164.1 - 5.6e-31 107.9 0.0 6.5e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESA09164.1 - 2.4e-12 46.5 0.0 5.5e-12 45.4 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 ESA09164.1 - 4.7e-09 36.0 0.1 1.4e-08 34.4 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 ESA09164.1 - 7.6e-06 25.1 0.0 8.9e-06 24.9 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_4 PF07993.7 ESA09164.1 - 3.5e-05 22.8 0.0 0.15 10.9 0.0 2.7 2 1 1 3 3 3 2 Male sterility protein 3Beta_HSD PF01073.14 ESA09164.1 - 0.00026 19.8 0.1 0.00035 19.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 ESA09164.1 - 0.0011 18.8 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_7 PF13241.1 ESA09164.1 - 0.011 16.0 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding RmlD_sub_bind PF04321.12 ESA09164.1 - 0.016 14.1 0.0 0.032 13.1 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain DXP_reductoisom PF02670.11 ESA09164.1 - 0.093 13.2 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Polysacc_synt_2 PF02719.10 ESA09164.1 - 0.12 11.2 0.0 0.23 10.3 0.0 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Apis_Csd PF11671.3 ESA09165.1 - 0.16 11.7 4.2 0.21 11.3 2.9 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein FAD_binding_2 PF00890.19 ESA09166.1 - 4.8e-82 276.0 0.1 6e-82 275.7 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.23 ESA09166.1 - 4.7e-23 80.7 0.0 5.3e-22 77.4 0.0 2.4 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.19 ESA09166.1 - 2.8e-14 52.7 0.2 1.4e-08 34.0 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA09166.1 - 4.1e-10 39.5 0.3 3.9e-09 36.3 0.2 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 ESA09166.1 - 1.7e-09 37.8 0.0 3.9e-07 30.1 0.0 2.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 ESA09166.1 - 5.5e-09 34.9 3.1 0.00014 20.5 0.1 3.4 3 0 0 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.2 ESA09166.1 - 7.7e-08 31.8 1.0 1.4e-07 30.9 0.7 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 ESA09166.1 - 1.6e-07 31.6 0.3 1.5e-06 28.4 0.2 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESA09166.1 - 1.7e-06 27.1 2.2 0.0038 16.1 0.4 3.1 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_9 PF13454.1 ESA09166.1 - 9.5e-06 25.4 0.0 0.00014 21.6 0.0 2.8 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.12 ESA09166.1 - 2.7e-05 23.3 1.2 0.00093 18.3 0.3 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 ESA09166.1 - 0.00029 20.0 0.3 0.00055 19.0 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 ESA09166.1 - 0.0031 17.8 2.2 0.0071 16.7 0.4 2.5 2 1 1 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 ESA09166.1 - 0.0035 17.5 0.0 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.13 ESA09166.1 - 0.044 13.4 0.0 0.082 12.5 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 ESA09166.1 - 0.055 13.4 0.2 0.35 10.8 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain Lycopene_cycl PF05834.7 ESA09166.1 - 0.057 12.3 0.1 0.085 11.7 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GDI PF00996.13 ESA09166.1 - 0.075 11.3 0.1 0.12 10.7 0.1 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor AlaDh_PNT_C PF01262.16 ESA09166.1 - 0.092 12.3 0.2 0.24 10.9 0.1 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RRM_1 PF00076.17 ESA09167.1 - 2.1e-13 49.6 0.0 2.7e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA09167.1 - 1.7e-11 43.8 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA09167.1 - 1.3e-07 31.3 0.0 2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cut8_N PF14482.1 ESA09168.1 - 5.5 7.0 8.5 2.2 8.3 3.2 2.0 1 1 1 2 2 2 0 Cut8 proteasome-binding domain FAD_binding_8 PF08022.7 ESA09169.1 - 1.3e-22 79.6 0.0 2.6e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 ESA09169.1 - 2.4e-19 69.7 0.0 9e-19 67.9 0.0 1.8 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 ESA09169.1 - 3.3e-19 69.1 9.2 7.3e-19 68.0 6.4 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 ESA09169.1 - 9.8e-06 25.6 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Dimer_Tnp_hAT PF05699.9 ESA09170.1 - 0.00083 18.9 0.5 0.0013 18.2 0.3 1.3 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region GST_C PF00043.20 ESA09171.1 - 8.9e-06 25.6 0.0 1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA09171.1 - 0.012 15.5 0.1 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Oxidored_q4 PF00507.14 ESA09173.1 - 0.02 14.6 1.0 0.028 14.2 0.7 1.3 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Voltage_CLC PF00654.15 ESA09177.1 - 0.0086 15.1 1.3 0.011 14.7 0.9 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel DUF3112 PF11309.3 ESA09177.1 - 0.013 15.3 4.4 0.045 13.5 3.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) DUF2207 PF09972.4 ESA09178.1 - 0.024 13.2 0.6 0.026 13.1 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ant_C PF05586.6 ESA09178.1 - 0.047 14.1 0.1 0.064 13.7 0.1 1.1 1 0 0 1 1 1 0 Anthrax receptor C-terminus region BLVR PF06375.6 ESA09178.1 - 1.4 8.7 6.4 1.7 8.4 4.5 1.1 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) DUF4024 PF13216.1 ESA09178.1 - 1.5 8.6 5.2 15 5.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) DUF1903 PF08991.5 ESA09179.1 - 1.1e-17 63.9 7.1 1.3e-17 63.7 4.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) Rota_NS53 PF00981.12 ESA09179.1 - 0.014 14.0 0.4 0.015 13.9 0.3 1.0 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) Bac_DNA_binding PF00216.16 ESA09179.1 - 0.12 12.4 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial DNA-binding protein CHCH PF06747.8 ESA09179.1 - 0.33 10.9 11.0 0.59 10.1 7.6 1.5 1 0 0 1 1 1 0 CHCH domain Pet191_N PF10203.4 ESA09179.1 - 4.8 7.2 11.2 0.56 10.2 5.0 1.5 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Vps53_N PF04100.7 ESA09181.1 - 6.8e-108 360.8 15.7 6.8e-108 360.8 10.9 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal DUF2450 PF10475.4 ESA09181.1 - 0.013 14.4 11.2 0.041 12.7 7.7 1.9 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) DUF2451 PF10474.4 ESA09181.1 - 0.015 15.0 0.1 0.015 15.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function C-terminus (DUF2451) Flagellin_N PF00669.15 ESA09181.1 - 0.082 12.6 0.7 0.19 11.5 0.2 1.8 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region MCPsignal PF00015.16 ESA09181.1 - 0.15 11.5 4.7 0.18 11.3 2.0 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Phage_HK97_TLTM PF06120.6 ESA09181.1 - 0.8 8.9 4.8 1.4 8.1 3.3 1.4 1 0 0 1 1 1 0 Tail length tape measure protein IncA PF04156.9 ESA09181.1 - 1.4 8.5 16.8 0.015 14.8 5.4 2.3 3 0 0 3 3 3 0 IncA protein Rhabdo_M2 PF04785.7 ESA09183.1 - 0.079 11.9 0.0 0.079 11.9 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus matrix protein M2 RabGAP-TBC PF00566.13 ESA09184.1 - 2.9e-36 124.9 9.8 3.8e-18 65.7 3.7 3.3 2 1 0 2 2 2 2 Rab-GTPase-TBC domain Mon1 PF03164.9 ESA09185.1 - 1.6e-144 481.5 0.8 2e-144 481.2 0.5 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Uma2 PF05685.7 ESA09186.1 - 3.6e-06 26.4 0.0 6.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease FAD_binding_3 PF01494.14 ESA09187.1 - 2.6e-20 72.7 0.0 4.7e-12 45.6 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_9 PF13454.1 ESA09187.1 - 0.00052 19.8 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA09187.1 - 0.00067 19.6 0.0 0.0018 18.2 0.0 1.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 ESA09187.1 - 0.0093 16.0 0.0 0.031 14.3 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESA09187.1 - 0.12 11.2 0.0 0.61 8.9 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.19 ESA09187.1 - 0.18 10.7 0.0 1.8 7.3 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase F-box PF00646.28 ESA09188.1 - 1.1e-06 28.0 0.3 3.2e-06 26.6 0.2 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA09188.1 - 7.2e-05 22.4 1.8 0.00015 21.4 0.2 2.4 3 0 0 3 3 3 1 F-box-like DUF262 PF03235.9 ESA09189.1 - 2.1e-05 24.5 3.6 0.00033 20.7 2.5 2.5 1 1 0 1 1 1 1 Protein of unknown function DUF262 NAAA-beta PF15508.1 ESA09189.1 - 0.05 13.9 0.1 2.4 8.5 0.0 3.3 4 0 0 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase WWbp PF10349.4 ESA09191.1 - 1.3e-07 32.4 0.1 2.1e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 WW-domain ligand protein GRAM PF02893.15 ESA09191.1 - 2.7e-06 26.7 0.0 4.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.3 ESA09191.1 - 3.9e-05 23.3 0.0 9.3e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.1 ESA09191.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain PH PF00169.24 ESA09192.1 - 2.6e-15 56.4 0.9 5.3e-15 55.5 0.7 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 ESA09192.1 - 2.8e-10 40.4 1.6 6.2e-10 39.3 1.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 ESA09192.1 - 0.018 15.0 1.3 0.26 11.3 0.1 2.4 1 1 1 2 2 2 0 Pleckstrin homology domain LURAP PF14854.1 ESA09192.1 - 1.4 8.6 5.4 3.2 7.5 3.7 1.7 1 0 0 1 1 1 0 Leucine rich adaptor protein DUF4419 PF14388.1 ESA09194.1 - 1.9e-60 204.6 3.3 2.1e-60 204.4 2.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Glyco_transf_25 PF01755.12 ESA09194.1 - 0.0078 15.8 1.6 0.012 15.3 1.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Pox_P35 PF03213.9 ESA09194.1 - 0.14 11.1 2.3 0.15 11.0 1.6 1.4 1 1 0 1 1 1 0 Poxvirus P35 protein Albumin_I PF08027.6 ESA09195.1 - 0.089 12.5 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Albumin I zf-tcix PF14952.1 ESA09195.1 - 0.13 11.6 0.4 0.22 10.8 0.2 1.4 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DZR PF12773.2 ESA09195.1 - 0.25 11.1 2.3 0.17 11.6 0.5 1.5 2 0 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.1 ESA09195.1 - 0.38 11.0 2.5 1.4 9.2 1.7 2.0 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.5 ESA09195.1 - 0.4 10.6 2.1 1.2 9.1 0.1 2.4 3 0 0 3 3 3 0 Zinc ribbon domain Prefoldin PF02996.12 ESA09196.1 - 0.031 13.9 0.1 0.89 9.2 0.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit ADIP PF11559.3 ESA09196.1 - 0.33 10.8 3.3 1.9 8.3 0.5 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Med9 PF07544.8 ESA09196.1 - 0.83 9.4 3.5 2.7 7.8 0.1 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FlxA PF14282.1 ESA09196.1 - 1.3 9.0 9.0 0.17 11.8 2.5 2.0 2 0 0 2 2 2 0 FlxA-like protein Myb_DNA-bind_6 PF13921.1 ESA09198.1 - 0.0001 22.3 0.5 0.0047 16.9 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA09198.1 - 0.0046 16.9 0.1 3.4 7.7 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Polysacc_deac_1 PF01522.16 ESA09201.1 - 2.5e-33 114.3 0.0 3.9e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA09201.1 - 0.011 14.7 0.0 0.014 14.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Trep_Strep PF09605.5 ESA09202.1 - 0.028 14.1 16.3 0.038 13.6 11.3 1.2 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Seryl_tRNA_N PF02403.17 ESA09204.1 - 0.021 14.8 11.8 0.021 14.8 8.2 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3667 PF12412.3 ESA09204.1 - 0.039 13.2 0.2 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3667) Mt_ATP-synt_D PF05873.7 ESA09204.1 - 0.12 12.0 6.2 0.02 14.5 1.7 1.7 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DivIC PF04977.10 ESA09204.1 - 0.46 10.0 9.9 0.98 8.9 6.1 2.0 1 1 1 2 2 2 0 Septum formation initiator Biopterin_H PF00351.16 ESA09204.1 - 0.71 8.5 6.0 0.051 12.3 0.5 1.7 3 0 0 3 3 3 0 Biopterin-dependent aromatic amino acid hydroxylase APG6 PF04111.7 ESA09204.1 - 0.79 8.7 18.1 0.12 11.3 8.7 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF607 PF04678.8 ESA09204.1 - 0.94 9.3 4.2 1.1 9.1 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF607 Fib_alpha PF08702.5 ESA09204.1 - 1 9.4 13.7 0.25 11.4 6.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 ESA09204.1 - 3 7.6 7.5 7.1 6.4 5.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MbeB_N PF04837.7 ESA09204.1 - 6.4 6.9 9.1 16 5.7 1.3 3.1 1 1 2 3 3 3 0 MbeB-like, N-term conserved region IncA PF04156.9 ESA09204.1 - 8.8 5.8 13.8 1 8.8 6.6 1.6 2 0 0 2 2 2 0 IncA protein Pkinase_Tyr PF07714.12 ESA09205.1 - 1.4e-35 122.6 0.0 1.5e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09205.1 - 1.3e-27 96.6 0.0 1.4e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain MORN_2 PF07661.8 ESA09205.1 - 0.048 13.6 0.8 0.19 11.8 0.4 2.2 2 0 0 2 2 2 0 MORN repeat variant PsbU PF06514.6 ESA09205.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 1 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pkinase PF00069.20 ESA09206.1 - 9.3e-32 110.1 1.2 1.1e-31 109.9 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09206.1 - 2.6e-29 102.0 0.3 3.1e-29 101.8 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA09206.1 - 7.1e-05 21.9 0.1 0.00011 21.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA09206.1 - 0.0019 17.5 0.9 0.003 16.9 0.7 1.3 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA09206.1 - 0.011 15.0 0.3 0.039 13.2 0.2 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ESA09206.1 - 0.016 14.9 0.2 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_6 PF13516.1 ESA09209.1 - 1.8e-07 30.5 20.7 0.012 15.5 0.0 7.6 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.2 ESA09209.1 - 7e-05 22.3 23.8 0.027 14.0 0.8 5.6 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) DUF4319 PF14203.1 ESA09209.1 - 0.0093 15.4 0.5 0.055 13.0 0.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4319) DUF3783 PF12646.2 ESA09209.1 - 0.029 14.1 1.4 0.065 12.9 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) Imm3 PF14425.1 ESA09209.1 - 0.078 12.9 6.9 0.034 14.1 2.2 2.1 2 0 0 2 2 2 0 Immunity protein Imm3 DUF2400 PF09674.5 ESA09209.1 - 0.38 10.4 3.2 0.34 10.5 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) LRR_1 PF00560.28 ESA09209.1 - 0.96 9.7 15.5 21 5.6 0.0 6.7 7 1 0 7 7 7 0 Leucine Rich Repeat DASH_Dad1 PF08649.5 ESA09210.1 - 0.083 12.6 0.9 0.16 11.6 0.6 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad1 Pkinase PF00069.20 ESA09210.1 - 0.11 11.6 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain NUMOD3 PF07460.6 ESA09212.1 - 0.29 11.0 2.2 0.34 10.8 0.6 1.8 2 0 0 2 2 2 0 NUMOD3 motif (2 copies) Methyltransf_11 PF08241.7 ESA09217.1 - 9.2e-14 51.7 0.0 2.5e-13 50.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA09217.1 - 1.9e-13 50.4 0.0 2.5e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA09217.1 - 2.5e-11 43.3 0.0 1.1e-10 41.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA09217.1 - 9.2e-09 35.5 0.0 2.5e-08 34.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA09217.1 - 1.1e-08 34.5 0.0 2.5e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA09217.1 - 2.5e-08 34.2 0.0 4.3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA09217.1 - 2.1e-07 31.5 0.0 9.9e-07 29.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA09217.1 - 5.2e-06 25.6 0.0 1.5e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_29 PF03141.11 ESA09217.1 - 0.00031 19.2 0.0 0.0031 15.9 0.0 1.9 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.10 ESA09217.1 - 0.00081 19.0 0.0 0.0011 18.6 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_26 PF13659.1 ESA09217.1 - 0.0019 18.1 0.0 0.0061 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA09217.1 - 0.0044 16.4 0.0 0.01 15.2 0.0 1.6 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.6 ESA09217.1 - 0.042 12.5 0.0 0.13 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) FtsJ PF01728.14 ESA09217.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF4271 PF14093.1 ESA09218.1 - 0.061 12.9 1.6 0.14 11.8 1.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) RHD3 PF05879.7 ESA09219.1 - 1.1e-05 23.6 0.0 2.5e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 ESA09219.1 - 0.0011 18.0 0.1 0.0026 16.8 0.1 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 ESA09219.1 - 0.097 12.4 0.0 0.38 10.5 0.0 2.0 1 0 0 1 1 1 0 Dynamin family Reo_sigmaC PF04582.7 ESA09220.1 - 0.0032 16.7 4.6 0.0077 15.4 3.2 1.6 1 0 0 1 1 1 1 Reovirus sigma C capsid protein CorA PF01544.13 ESA09220.1 - 0.15 11.0 5.8 0.34 9.8 4.0 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HTH_WhiA PF02650.9 ESA09221.1 - 0.016 15.5 0.0 0.023 15.0 0.0 1.2 1 0 0 1 1 1 0 WhiA C-terminal HTH domain LRR_4 PF12799.2 ESA09223.1 - 0.014 15.0 24.3 0.3 10.7 0.1 4.8 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) DUF1319 PF07028.6 ESA09223.1 - 0.81 9.8 5.3 0.58 10.3 0.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1319) Pkinase_Tyr PF07714.12 ESA09224.1 - 0.012 14.7 0.0 0.27 10.2 0.0 2.5 3 1 0 3 3 3 0 Protein tyrosine kinase Orthopox_F7 PF05813.7 ESA09224.1 - 1.6 8.6 5.1 0.88 9.5 0.3 2.8 2 1 1 3 3 3 0 Orthopoxvirus F7 protein BTB PF00651.26 ESA09225.1 - 2.8e-15 56.2 0.0 6.9e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA09225.1 - 3.9e-08 33.3 1.4 3.9e-08 33.3 0.9 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA09225.1 - 6.3e-05 22.7 1.5 0.00022 21.0 0.1 2.8 2 1 0 2 2 2 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA09225.1 - 0.08 11.9 0.2 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein TLD PF07534.11 ESA09226.1 - 2.3e-12 47.0 1.3 4.1e-12 46.2 0.9 1.4 1 0 0 1 1 1 1 TLD TNV_CP PF03898.8 ESA09226.1 - 0.064 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Myb_DNA-bind_6 PF13921.1 ESA09230.1 - 0.97 9.5 10.3 23 5.1 0.3 3.9 3 1 1 4 4 4 0 Myb-like DNA-binding domain Pkinase_Tyr PF07714.12 ESA09232.1 - 5.3e-06 25.6 0.0 0.34 9.9 0.0 3.7 4 0 0 4 4 4 3 Protein tyrosine kinase DUF4413 PF14372.1 ESA09232.1 - 8.6e-05 22.4 1.5 2.7 8.0 0.0 3.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4413) DUF2760 PF10816.3 ESA09232.1 - 0.0016 17.9 0.0 1.5 8.3 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF2760) Pkinase PF00069.20 ESA09232.1 - 0.0052 15.9 3.1 1.2 8.1 0.0 3.7 4 0 0 4 4 4 1 Protein kinase domain DUF900 PF05990.7 ESA09232.1 - 0.0055 16.0 0.3 7.8 5.7 0.0 3.1 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF900) Peptidase_M15_2 PF05951.8 ESA09232.1 - 0.024 14.1 0.1 9.4 5.6 0.0 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF882) FCD PF07729.7 ESA09232.1 - 0.028 14.7 0.0 39 4.5 0.0 3.2 3 0 0 3 3 3 0 FCD domain DUF4200 PF13863.1 ESA09232.1 - 0.03 14.2 0.5 29 4.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF3991 PF13154.1 ESA09232.1 - 0.31 11.2 3.6 21 5.4 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3991) Streptin-Immun PF11083.3 ESA09232.1 - 0.32 11.0 3.1 69 3.5 0.0 3.3 3 0 0 3 3 3 0 Lantibiotic streptin immunity protein DUF551 PF04448.7 ESA09232.1 - 3.4 8.4 5.7 1.1e+02 3.6 0.1 4.0 3 2 0 3 3 3 0 Protein of unknown function (DUF551) Pkinase PF00069.20 ESA09234.1 - 1.4e-43 148.8 0.2 2e-43 148.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09234.1 - 1.5e-43 148.7 0.0 1.9e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA09234.1 - 0.00034 19.7 0.4 0.001 18.2 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA09234.1 - 0.0015 18.3 1.0 0.0031 17.2 0.7 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA09234.1 - 0.011 15.1 0.2 0.011 15.1 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.9 ESA09234.1 - 0.03 13.3 1.9 1.5 7.7 0.2 2.3 1 1 1 2 2 2 0 Fructosamine kinase F-box-like PF12937.2 ESA09235.1 - 2.6e-08 33.4 0.4 7e-08 32.0 0.3 1.8 1 0 0 1 1 1 1 F-box-like LRR_7 PF13504.1 ESA09235.1 - 0.04 14.0 0.4 19 6.0 0.0 5.0 5 0 0 5 5 5 0 Leucine rich repeat Tht1 PF04163.7 ESA09239.1 - 1.1e-10 40.6 1.9 1.2e-10 40.4 1.3 1.2 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein Bacillus_HBL PF05791.6 ESA09239.1 - 0.0032 16.8 0.2 0.0044 16.4 0.1 1.3 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) BUD22 PF09073.5 ESA09239.1 - 0.012 14.7 0.2 0.012 14.6 0.2 1.1 1 0 0 1 1 1 0 BUD22 MAP65_ASE1 PF03999.7 ESA09239.1 - 0.012 14.2 1.6 0.015 13.9 1.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF3921 PF13060.1 ESA09239.1 - 0.024 14.4 0.0 0.051 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) Baculo_PEP_C PF04513.7 ESA09239.1 - 0.12 12.2 3.3 0.32 10.8 2.3 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus XhlA PF10779.4 ESA09239.1 - 1.6 8.7 4.9 31 4.5 3.4 2.7 1 1 0 1 1 1 0 Haemolysin XhlA BLOC1_2 PF10046.4 ESA09239.1 - 3.2 7.9 7.8 0.53 10.4 1.5 2.4 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tox-WTIP PF15654.1 ESA09240.1 - 0.016 14.7 0.1 0.023 14.3 0.1 1.2 1 0 0 1 1 1 0 Toxin with a conserved tryptophan and TIP tripeptide motif MitoNEET_N PF10660.4 ESA09240.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus SH2_2 PF14633.1 ESA09240.1 - 0.04 12.9 0.0 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 SH2 domain Choline_kinase PF01633.15 ESA09240.1 - 0.076 12.5 0.0 0.086 12.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 ESA09242.1 - 5.9e-33 114.0 0.0 1e-32 113.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09242.1 - 1.1e-32 113.2 0.0 2.5e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA09242.1 - 4.4e-10 39.8 11.2 5.3e-06 26.8 0.0 4.8 4 1 0 4 4 4 2 Sel1 repeat TPR_6 PF13174.1 ESA09242.1 - 0.0032 17.8 0.9 0.066 13.6 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA09242.1 - 4.5 7.4 8.0 9 6.4 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat HD PF01966.17 ESA09243.1 - 6e-13 48.8 0.5 1.8e-12 47.3 0.3 1.9 1 0 0 1 1 1 1 HD domain Pkinase PF00069.20 ESA09244.1 - 4.7e-24 84.9 0.4 7.1e-22 77.8 0.3 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09244.1 - 2.5e-22 79.2 0.0 3.5e-20 72.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1616 PF07760.6 ESA09245.1 - 0.026 13.6 0.0 0.028 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) ATG16 PF08614.6 ESA09245.1 - 0.04 13.7 6.8 0.065 13.0 4.7 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Arc_PepC PF06819.6 ESA09245.1 - 0.17 11.7 2.5 0.44 10.4 1.7 1.7 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain 5_3_exonuc PF01367.15 ESA09245.1 - 2.3 8.4 4.8 2.8 8.2 0.1 2.6 1 1 1 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold HALZ PF02183.13 ESA09245.1 - 3.6 7.3 7.9 5.1 6.8 0.2 3.6 3 1 0 3 3 3 0 Homeobox associated leucine zipper DUF4094 PF13334.1 ESA09245.1 - 6.4 7.2 7.6 43 4.5 4.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) I_LWEQ PF01608.12 ESA09245.1 - 9 6.2 10.6 2.1 8.2 4.5 1.8 1 1 1 2 2 2 0 I/LWEQ domain Aminotran_4 PF01063.14 ESA09247.1 - 2.8e-17 62.9 0.0 3.5e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class IV tRNA-synt_2b PF00587.20 ESA09248.1 - 4.5e-33 114.2 0.0 6.1e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.15 ESA09248.1 - 0.0068 15.6 0.0 0.011 14.9 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) SMC_N PF02463.14 ESA09249.1 - 7.2e-40 136.5 0.5 7.2e-40 136.5 0.4 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESA09249.1 - 1.2e-15 58.4 6.3 1.7e-15 57.8 4.4 1.2 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 ESA09249.1 - 2.7e-08 34.1 3.1 7.5e-08 32.6 2.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESA09249.1 - 3e-07 29.8 0.0 5.8e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ESA09249.1 - 0.0005 19.2 16.0 0.013 14.6 11.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.22 ESA09249.1 - 0.018 15.3 2.1 0.05 13.9 1.4 2.0 1 1 0 1 1 1 0 ABC transporter DUF2373 PF10180.4 ESA09249.1 - 0.019 14.4 0.0 0.053 13.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) SMC_N PF02463.14 ESA09250.1 - 1.1e-37 129.4 0.1 1.3e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA09250.1 - 9.5e-07 29.0 0.1 1.5e-06 28.3 0.1 1.4 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 ESA09250.1 - 0.013 15.4 0.0 0.027 14.4 0.0 1.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit 5_3_exonuc_N PF02739.11 ESA09250.1 - 0.033 13.5 0.4 0.2 10.9 0.1 2.0 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain SAS4 PF15460.1 ESA09250.1 - 0.07 13.0 1.5 0.14 12.0 1.1 1.4 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 DUF4618 PF15397.1 ESA09250.1 - 0.081 12.2 2.6 0.12 11.6 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Uds1 PF15456.1 ESA09250.1 - 0.13 12.2 2.1 0.45 10.5 1.4 1.8 1 1 0 1 1 1 0 Up-regulated During Septation ABC_tran PF00005.22 ESA09250.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter zf-C2H2_jaz PF12171.3 ESA09251.1 - 3.1e-10 39.8 0.8 5.4e-10 39.1 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 ESA09251.1 - 0.007 16.4 0.2 0.0087 16.1 0.1 1.3 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 ESA09251.1 - 0.0095 16.1 0.2 0.018 15.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Spore_GerAC PF05504.6 ESA09251.1 - 0.02 14.6 0.1 0.03 14.1 0.0 1.3 1 1 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal zf-U1 PF06220.7 ESA09251.1 - 0.035 13.6 0.5 0.035 13.6 0.4 2.0 2 0 0 2 2 2 0 U1 zinc finger HSP70 PF00012.15 ESA09252.1 - 1.9e-209 696.5 0.1 2.2e-209 696.3 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA09252.1 - 3.7e-16 58.6 0.1 4.3e-15 55.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA09252.1 - 0.0025 16.9 0.0 0.019 14.0 0.0 2.1 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase FGGY_C PF02782.11 ESA09252.1 - 0.0039 16.8 0.0 0.042 13.4 0.0 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Phage_int_SAM_1 PF02899.12 ESA09252.1 - 0.036 14.2 0.2 0.085 13.0 0.1 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain CorA PF01544.13 ESA09252.1 - 1.4 7.8 9.0 4.9 6.0 0.7 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Lipl32 PF12103.3 ESA09253.1 - 0.02 14.3 0.5 0.026 14.0 0.4 1.1 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order CTD PF12815.2 ESA09254.1 - 7.5e-05 23.1 0.0 0.0054 17.1 0.0 2.4 1 1 0 1 1 1 1 Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4481 PF14800.1 ESA09254.1 - 0.11 11.4 4.6 9.4 5.0 0.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4481) DUF843 PF05814.6 ESA09254.1 - 0.16 11.7 8.2 6.4 6.6 0.2 4.9 3 2 3 6 6 6 0 Baculovirus protein of unknown function (DUF843) Proho_convert PF12177.3 ESA09254.1 - 0.35 10.4 5.6 35 4.0 0.0 3.8 3 1 1 4 4 4 0 Prohormone convertase enzyme FAM212 PF15342.1 ESA09254.1 - 0.78 9.3 26.8 7.5 6.2 0.5 6.0 4 1 1 5 5 5 0 FAM212 family FixG_C PF11614.3 ESA09254.1 - 2.5 8.2 8.6 19 5.4 0.1 3.5 3 1 1 4 4 4 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Myb_DNA-bind_6 PF13921.1 ESA09254.1 - 4.2 7.5 12.5 21 5.3 0.2 4.3 1 1 4 5 5 5 0 Myb-like DNA-binding domain GlyL_C PF12524.3 ESA09254.1 - 8.8 6.3 9.8 6.8e+02 0.2 6.1 3.6 1 1 0 1 1 1 0 dsDNA virus glycoprotein L C terminal Trypsin_2 PF13365.1 ESA09257.1 - 0.0075 16.2 0.0 0.027 14.4 0.0 1.9 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.8 ESA09257.1 - 0.022 13.7 0.1 0.34 9.8 0.0 2.1 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Spuma_A9PTase PF03539.9 ESA09258.1 - 0.019 14.8 0.2 4.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Spumavirus aspartic protease (A9) Pkinase PF00069.20 ESA09259.1 - 6.3e-67 225.4 0.0 7.4e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09259.1 - 9.4e-31 106.8 0.1 1.2e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA09259.1 - 6.3e-06 25.3 0.0 1.7e-05 23.9 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA09259.1 - 0.0031 16.6 0.1 0.0053 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family COX6A PF02046.10 ESA09260.1 - 3.7e-30 104.2 0.1 4.2e-30 104.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Orbi_NS3 PF01616.11 ESA09260.1 - 0.037 12.9 0.0 0.063 12.2 0.0 1.4 1 1 1 2 2 2 0 Orbivirus NS3 TFIID-18kDa PF02269.11 ESA09261.1 - 5.3e-27 93.4 0.4 6.1e-27 93.2 0.3 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TFIID_20kDa PF03847.8 ESA09261.1 - 0.00011 22.4 0.2 0.00019 21.6 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 ESA09261.1 - 0.0057 16.7 0.1 0.03 14.4 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 GLTSCR1 PF15249.1 ESA09261.1 - 0.088 12.9 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 Glioma tumor suppressor candidate region Strep_67kDa_ant PF06100.6 ESA09264.1 - 0.045 12.0 0.3 0.051 11.9 0.2 1.1 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Pkinase_Tyr PF07714.12 ESA09265.1 - 4e-16 58.8 0.0 9.9e-16 57.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09265.1 - 2.4e-09 36.7 0.0 2.4e-09 36.7 0.0 2.5 3 0 0 3 3 3 1 Protein kinase domain Prok-TraM PF09228.5 ESA09267.1 - 0.088 12.9 0.5 0.12 12.5 0.1 1.4 2 0 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM DUF1002 PF06207.6 ESA09267.1 - 0.31 10.3 3.7 0.43 9.8 2.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1002) Mdv1 PF11542.3 ESA09267.1 - 0.47 10.4 2.4 3.8 7.5 0.3 2.3 2 0 0 2 2 2 0 Mitochondrial division protein 1 HPD PF05044.7 ESA09267.1 - 1.2 8.8 7.0 1.7 8.2 2.4 2.1 1 1 1 2 2 2 0 Homeo-prospero domain zf-C2H2_2 PF12756.2 ESA09267.1 - 2.4 8.3 5.4 29 4.8 0.4 3.1 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Eaf7 PF07904.8 ESA09267.1 - 2.5 8.1 7.3 1.5 8.8 1.1 2.2 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 ERM PF00769.14 ESA09268.1 - 0.14 11.7 3.0 0.18 11.3 2.1 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family eIF-3c_N PF05470.7 ESA09268.1 - 1.1 7.2 7.0 1.3 7.0 4.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Epimerase PF01370.16 ESA09269.1 - 0.0006 19.3 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Hydrolase_6 PF13344.1 ESA09270.1 - 4.4e-26 90.7 0.0 8.5e-26 89.7 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA09270.1 - 3.8e-13 50.3 0.0 4.8e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA09270.1 - 4.9e-13 48.5 0.0 1.4e-12 47.0 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 ESA09270.1 - 0.00022 21.5 0.0 0.071 13.3 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 ESA09270.1 - 0.032 13.5 0.0 2.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase STAS PF01740.16 ESA09270.1 - 0.075 12.4 0.0 0.39 10.1 0.0 1.9 2 0 0 2 2 2 0 STAS domain Coiled-coil_56 PF09813.4 ESA09271.1 - 0.017 15.0 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 Kelch_2 PF07646.10 ESA09272.1 - 3.4e-11 42.4 6.2 0.051 13.3 0.0 6.0 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ESA09272.1 - 1.3e-10 40.8 19.3 0.0045 16.7 0.0 6.6 5 3 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA09272.1 - 4.9e-09 36.0 10.2 0.0019 18.2 0.6 6.0 5 2 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09272.1 - 8.6e-09 35.1 15.7 0.32 11.2 0.0 6.3 5 2 1 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESA09272.1 - 1.2e-07 31.0 12.0 0.056 12.9 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ESA09272.1 - 1.6e-07 31.1 11.5 0.0026 17.6 0.0 6.1 6 1 0 6 6 6 3 Kelch motif GPI-anchored PF10342.4 ESA09273.1 - 0.00082 19.7 2.3 0.0021 18.5 0.1 2.0 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Lamp PF01299.12 ESA09273.1 - 0.046 12.8 0.8 0.054 12.6 0.6 1.1 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) RRM_1 PF00076.17 ESA09274.1 - 1.1e-15 57.0 0.2 1.2e-07 31.2 0.0 3.6 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA09274.1 - 2.2e-14 53.1 0.0 2.3e-09 37.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA09274.1 - 5.3e-05 22.9 0.0 0.0049 16.6 0.0 3.0 2 2 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 ESA09274.1 - 0.067 12.9 0.0 0.82 9.4 0.0 2.4 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Lipase_3 PF01764.20 ESA09276.1 - 6.4e-38 129.5 0.0 8.4e-38 129.1 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESA09276.1 - 0.00062 19.2 0.0 0.003 16.9 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Cutinase PF01083.17 ESA09276.1 - 0.00071 19.3 0.1 0.0037 17.0 0.0 2.2 2 1 0 2 2 2 1 Cutinase Esterase PF00756.15 ESA09276.1 - 0.048 13.0 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative esterase BofC_C PF08955.5 ESA09276.1 - 0.071 13.1 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 BofC C-terminal domain PGAP1 PF07819.8 ESA09276.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein HMG_box PF00505.14 ESA09277.1 - 3.6e-05 23.9 0.2 7.8e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA09277.1 - 0.003 16.9 0.1 0.0041 16.4 0.1 1.2 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 DUF1539 PF07560.6 ESA09277.1 - 0.01 15.6 0.7 1.7 8.4 0.1 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) Coq4 PF05019.8 ESA09277.1 - 0.13 11.1 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 HsdM_N PF12161.3 ESA09277.1 - 0.6 10.5 5.6 3 8.2 0.3 2.2 1 1 1 2 2 2 0 HsdM N-terminal domain AIG1 PF04548.11 ESA09278.1 - 6.3e-14 51.5 0.7 9.9e-14 50.9 0.5 1.4 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA09278.1 - 1.6e-07 31.3 0.6 5.9e-07 29.4 0.4 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA09278.1 - 9.3e-05 23.2 2.5 0.0016 19.2 1.7 2.3 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESA09278.1 - 0.0037 17.5 3.4 0.0039 17.4 1.9 1.8 1 1 0 1 1 1 1 ABC transporter T2SE PF00437.15 ESA09278.1 - 0.007 15.2 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein GTP_EFTU PF00009.22 ESA09278.1 - 0.0088 15.4 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ESA09278.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 ESA09278.1 - 0.012 14.8 0.0 0.02 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA09278.1 - 0.014 14.8 0.4 0.017 14.5 0.3 1.7 1 1 0 1 1 1 0 AAA-like domain DUF87 PF01935.12 ESA09278.1 - 0.022 14.6 0.1 0.022 14.6 0.1 2.4 2 2 0 2 2 2 0 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 ESA09278.1 - 0.025 14.0 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.1 ESA09278.1 - 0.033 14.5 0.1 0.033 14.5 0.0 2.4 1 1 0 2 2 2 0 AAA domain NACHT PF05729.7 ESA09278.1 - 0.04 13.5 0.0 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 ESA09278.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Arf PF00025.16 ESA09278.1 - 0.087 12.0 0.0 0.17 11.0 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_22 PF13401.1 ESA09278.1 - 0.1 12.7 0.1 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA09278.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activ_2 PF14532.1 ESA09278.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.1 ESA09278.1 - 0.14 12.1 0.1 0.41 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.18 ESA09278.1 - 0.24 11.2 3.1 1.9 8.2 2.1 2.3 1 1 0 1 1 1 0 Dynamin family Cofilin_ADF PF00241.15 ESA09280.1 - 3.2e-13 49.6 0.1 3.4e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF965 PF06135.7 ESA09282.1 - 0.0094 15.9 0.4 0.024 14.6 0.1 1.7 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF965) Pneumo_M2 PF07380.6 ESA09282.1 - 0.12 12.4 1.1 1.7 8.6 0.1 2.2 2 1 0 2 2 2 0 Pneumovirus M2 protein Aida_N PF08910.5 ESA09283.1 - 0.063 13.5 0.3 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 Aida N-terminus Fer4_12 PF13353.1 ESA09283.1 - 0.078 13.0 0.1 0.24 11.4 0.0 1.8 1 1 0 1 1 1 0 4Fe-4S single cluster domain Fer4_14 PF13394.1 ESA09283.1 - 0.082 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain UBACT PF02134.16 ESA09284.1 - 0.098 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Repeat in ubiquitin-activating (UBA) protein CAP59_mtransfer PF11735.3 ESA09284.1 - 0.099 11.8 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 Transposase_21 PF02992.9 ESA09284.1 - 0.13 11.3 0.2 0.66 9.0 0.0 1.9 1 1 1 2 2 2 0 Transposase family tnp2 DUF4218 PF13960.1 ESA09285.1 - 0.00014 21.3 0.1 0.00039 19.8 0.0 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4218) Syja_N PF02383.13 ESA09287.1 - 4.5e-92 308.2 0.4 4.5e-92 308.2 0.3 1.9 2 0 0 2 2 2 1 SacI homology domain Gar1 PF04410.9 ESA09288.1 - 3e-37 127.4 2.9 3e-37 127.4 2.0 1.9 1 1 1 2 2 2 1 Gar1/Naf1 RNA binding region DUF1918 PF08940.6 ESA09288.1 - 0.068 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) HMG_box PF00505.14 ESA09289.1 - 0.00025 21.2 2.1 0.00046 20.3 1.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box RED_N PF07808.8 ESA09289.1 - 0.062 12.5 0.4 0.075 12.2 0.3 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region HMG_box_2 PF09011.5 ESA09290.1 - 0.0076 16.6 1.3 0.012 15.9 0.9 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA09290.1 - 0.13 12.5 1.3 0.35 11.1 0.9 1.8 1 1 0 1 1 1 0 HMG (high mobility group) box HMG_box PF00505.14 ESA09291.1 - 0.0014 18.8 2.6 0.0022 18.2 1.8 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09291.1 - 0.0029 17.9 3.0 0.0039 17.5 2.1 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA09292.1 - 0.00011 22.4 0.7 0.00024 21.3 0.5 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09292.1 - 0.00055 20.2 2.3 0.015 15.6 0.7 2.5 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.14 ESA09293.1 - 8.5e-10 38.7 5.2 1.1e-05 25.5 0.1 2.8 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09293.1 - 0.0034 17.7 5.9 0.39 11.1 0.2 2.7 2 1 0 2 2 2 2 HMG-box domain Ribosomal_L7Ae PF01248.21 ESA09298.1 - 8.4e-22 76.5 0.2 1.7e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Phe_tRNA-synt_N PF02912.13 ESA09298.1 - 0.023 14.3 0.0 0.094 12.4 0.0 2.0 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain Ufd2P_core PF10408.4 ESA09299.1 - 0.012 13.9 1.5 0.013 13.7 1.0 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core Yippee-Mis18 PF03226.9 ESA09300.1 - 1.3e-23 82.8 0.4 1.4e-23 82.7 0.2 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.3 ESA09300.1 - 0.0018 18.1 0.4 0.0037 17.1 0.3 1.5 1 1 0 1 1 1 1 C-terminal domain of RIG-I DUF2039 PF10217.4 ESA09300.1 - 0.016 15.1 0.4 0.095 12.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) Evr1_Alr PF04777.8 ESA09300.1 - 0.082 12.8 0.9 1.7 8.5 0.1 2.1 1 1 1 2 2 2 0 Erv1 / Alr family LIM PF00412.17 ESA09300.1 - 0.092 12.8 0.8 2.9 8.0 0.1 2.3 2 0 0 2 2 2 0 LIM domain AlcCBM31 PF11606.3 ESA09300.1 - 0.11 12.4 0.2 5.7 6.9 0.0 2.1 1 1 1 2 2 2 0 Family 31 carbohydrate binding protein HECT_2 PF09814.4 ESA09300.1 - 0.12 11.1 0.5 0.34 9.5 0.5 1.6 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Helitron_like_N PF14214.1 ESA09302.1 - 8.1e-14 51.7 0.1 2.5e-13 50.1 0.1 1.7 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus DUF3296 PF11726.3 ESA09302.1 - 0.036 13.6 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3296) HMG_box PF00505.14 ESA09303.1 - 4.3e-11 42.9 4.4 1.6e-10 41.1 3.0 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09303.1 - 1.6e-05 25.1 0.5 2.1e-05 24.7 0.3 1.2 1 0 0 1 1 1 1 HMG-box domain MAAL_C PF07476.6 ESA09303.1 - 0.015 14.2 0.0 0.018 13.9 0.0 1.0 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Rubrerythrin PF02915.12 ESA09303.1 - 0.039 14.2 0.3 0.044 14.1 0.2 1.3 1 0 0 1 1 1 0 Rubrerythrin DUF4359 PF14271.1 ESA09305.1 - 0.016 15.5 0.2 0.021 15.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4359) MSP7_C PF12948.2 ESA09305.1 - 0.087 13.0 2.0 0.15 12.3 1.3 1.5 1 1 0 1 1 1 0 MSP7-like protein C-terminal domain XhlA PF10779.4 ESA09305.1 - 0.92 9.4 4.8 2 8.3 3.3 1.7 1 1 0 1 1 1 0 Haemolysin XhlA mRNA_stabil PF13929.1 ESA09306.1 - 0.018 14.0 0.2 0.02 13.8 0.1 1.0 1 0 0 1 1 1 0 mRNA stabilisation zf-3CxxC PF13695.1 ESA09308.1 - 0.0048 17.0 10.2 0.0048 17.0 7.1 3.7 2 2 0 2 2 2 1 Zinc-binding domain zf-3CxxC PF13695.1 ESA09309.1 - 4.3e-10 39.7 19.6 4.7e-06 26.7 7.2 3.3 3 1 0 3 3 3 2 Zinc-binding domain DUF866 PF05907.8 ESA09309.1 - 0.0075 15.7 5.0 0.0075 15.7 3.5 2.1 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF866) Clathrin PF00637.15 ESA09309.1 - 0.032 13.8 1.5 0.036 13.6 0.3 1.7 2 0 0 2 2 2 0 Region in Clathrin and VPS AIG1 PF04548.11 ESA09309.1 - 0.12 11.4 2.6 0.24 10.4 0.2 2.2 1 1 1 2 2 2 0 AIG1 family Stc1 PF12898.2 ESA09309.1 - 1 9.4 17.9 0.52 10.4 3.0 3.4 2 2 0 2 2 2 0 Stc1 domain RFX_DNA_binding PF02257.10 ESA09309.1 - 6.8 6.9 9.2 6 7.0 0.0 3.7 4 1 0 4 4 4 0 RFX DNA-binding domain PM0188 PF11477.3 ESA09310.1 - 0.019 13.7 0.1 0.026 13.3 0.1 1.2 1 0 0 1 1 1 0 Sialyltransferase PMO188 Rsm22 PF09243.5 ESA09310.1 - 0.043 12.8 0.0 0.054 12.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Rsc14 PF08586.5 ESA09310.1 - 0.14 12.6 0.0 0.18 12.2 0.0 1.1 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Pkinase_Tyr PF07714.12 ESA09311.1 - 5.9e-46 156.6 0.0 7.3e-46 156.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09311.1 - 6.5e-44 150.0 0.0 9.3e-44 149.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-HC2 PF13490.1 ESA09311.1 - 0.085 12.8 0.4 0.17 11.8 0.2 1.5 1 0 0 1 1 1 0 Putative zinc-finger HMG_box PF00505.14 ESA09314.1 - 1.8e-21 76.1 1.5 2e-21 76.0 1.0 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09314.1 - 1.5e-07 31.6 0.5 1.7e-07 31.4 0.3 1.0 1 0 0 1 1 1 1 HMG-box domain p450 PF00067.17 ESA09316.1 - 8.5e-58 195.9 0.1 4.3e-36 124.4 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 CtIP_N PF10482.4 ESA09316.1 - 0.13 12.0 0.7 0.21 11.3 0.5 1.3 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF3510 PF12022.3 ESA09317.1 - 2.5e-13 50.2 1.4 2.5e-13 50.2 1.0 3.8 4 1 0 4 4 4 1 Domain of unknown function (DUF3510) Syntaxin-6_N PF09177.6 ESA09317.1 - 0.053 13.9 4.1 0.26 11.7 0.2 3.3 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Rap_GAP PF02145.10 ESA09318.1 - 1.6e-53 180.8 0.0 3.2e-53 179.8 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP 2OG-FeII_Oxy_2 PF13532.1 ESA09320.1 - 3.9e-15 56.1 0.0 1.4e-13 51.0 0.0 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESA09320.1 - 1.6e-09 37.9 0.0 3.5e-09 36.8 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily E2_bind PF08825.5 ESA09320.1 - 0.1 12.3 0.3 0.17 11.6 0.2 1.4 1 0 0 1 1 1 0 E2 binding domain MukB PF04310.7 ESA09325.1 - 0.022 14.0 0.0 0.04 13.2 0.0 1.5 2 0 0 2 2 2 0 MukB N-terminal HMG_box PF00505.14 ESA09326.1 - 1.6e-15 57.0 0.6 1.6e-15 57.0 0.4 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09326.1 - 0.00034 20.9 0.5 0.00034 20.9 0.3 2.3 3 0 0 3 3 3 1 HMG-box domain UPF0560 PF10577.4 ESA09326.1 - 0.00067 18.0 12.3 0.00067 18.0 8.5 1.4 2 0 0 2 2 2 1 Uncharacterised protein family UPF0560 Cas_Csy3 PF09615.5 ESA09328.1 - 0.075 12.1 0.1 0.075 12.1 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) Myotub-related PF06602.9 ESA09329.1 - 9.7e-135 448.8 3.9 1.2e-134 448.6 2.7 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.22 ESA09329.1 - 0.00086 18.7 0.0 0.0022 17.3 0.0 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESA09329.1 - 0.0018 17.8 0.5 0.0048 16.4 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 ESA09329.1 - 0.092 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family ABC_tran PF00005.22 ESA09330.1 - 9.6e-27 93.9 0.0 1.4e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA09330.1 - 2.8e-11 43.9 0.0 1.7e-06 28.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 ESA09330.1 - 6.8e-05 23.2 0.0 7.7e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 ESA09330.1 - 0.00022 20.5 0.0 0.006 15.8 0.0 2.0 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 ESA09330.1 - 0.00023 21.2 0.1 0.00036 20.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA09330.1 - 0.00024 21.1 0.0 0.00044 20.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESA09330.1 - 0.0003 20.0 0.0 0.00058 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA09330.1 - 0.00032 20.2 0.0 0.00049 19.6 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain AAA_29 PF13555.1 ESA09330.1 - 0.00034 20.0 0.1 0.00091 18.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 ESA09330.1 - 0.00091 20.0 0.1 0.0014 19.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain UPF0079 PF02367.12 ESA09330.1 - 0.0011 18.6 0.6 0.0036 16.9 0.1 2.0 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 ESA09330.1 - 0.0011 18.6 0.5 0.018 14.7 0.1 2.1 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.1 ESA09330.1 - 0.0012 18.5 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 ESA09330.1 - 0.0013 18.6 0.0 0.0067 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 ESA09330.1 - 0.0027 17.4 0.2 0.0061 16.2 0.0 1.6 2 0 0 2 2 2 1 Archaeal ATPase AAA_15 PF13175.1 ESA09330.1 - 0.0038 16.3 0.8 0.33 9.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 ESA09330.1 - 0.0049 17.1 0.1 0.0082 16.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA09330.1 - 0.009 16.2 0.0 0.03 14.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESA09330.1 - 0.012 14.3 0.1 0.015 13.9 0.1 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NTPase_1 PF03266.10 ESA09330.1 - 0.013 15.2 0.6 0.043 13.5 0.2 1.9 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.1 ESA09330.1 - 0.015 15.1 0.0 0.18 11.7 0.0 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 ESA09330.1 - 0.018 14.4 0.0 0.04 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 ESA09330.1 - 0.03 13.8 0.0 0.075 12.6 0.0 1.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 ESA09330.1 - 0.031 13.1 0.0 0.059 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain T2SE PF00437.15 ESA09330.1 - 0.037 12.9 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.12 ESA09330.1 - 0.037 13.4 0.0 0.093 12.1 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_ATPase PF09818.4 ESA09330.1 - 0.039 12.5 0.0 0.79 8.2 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_5 PF07728.9 ESA09330.1 - 0.064 12.9 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_11 PF13086.1 ESA09330.1 - 0.074 12.6 0.0 0.11 12.0 0.0 1.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA09330.1 - 0.097 12.8 0.1 0.2 11.8 0.1 1.7 1 1 0 1 1 1 0 RNA helicase MobB PF03205.9 ESA09330.1 - 0.11 12.2 0.1 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATP-synt_ab PF00006.20 ESA09330.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.2 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 ESA09330.1 - 0.12 11.9 0.5 0.19 11.3 0.3 1.3 1 0 0 1 1 1 0 AAA domain Lactamase_B PF00753.22 ESA09331.1 - 1.3e-17 64.1 0.1 1.7e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Collagen PF01391.13 ESA09331.1 - 0.37 10.3 3.0 0.67 9.5 2.1 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) SUKH-3 PF14433.1 ESA09333.1 - 0.021 14.6 0.5 0.026 14.2 0.1 1.4 2 0 0 2 2 2 0 SUKH-3 immunity protein ADH_N PF08240.7 ESA09335.1 - 1.7e-18 66.3 0.8 2e-18 66.1 0.2 1.4 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain HAS-barrel PF09378.5 ESA09336.1 - 0.015 15.1 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 HAS barrel domain EI24 PF07264.6 ESA09340.1 - 3.1e-12 46.3 21.7 4.7e-12 45.8 15.1 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF3989 PF13150.1 ESA09340.1 - 1.5 8.3 4.4 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) SANTA PF09133.5 ESA09343.1 - 0.022 14.7 0.1 0.032 14.1 0.1 1.3 1 0 0 1 1 1 0 SANTA (SANT Associated) DUF16 PF01519.11 ESA09345.1 - 5.6 7.2 7.8 0.25 11.5 0.7 2.4 2 2 0 2 2 2 0 Protein of unknown function DUF16 DUF2972 PF11186.3 ESA09345.1 - 6.1 6.6 13.4 1.9e+03 -1.5 9.3 3.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2972) UBX PF00789.15 ESA09346.1 - 4.4e-16 58.7 0.0 1.1e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 UBX domain Orthopox_A5L PF06193.6 ESA09346.1 - 0.00046 20.1 0.0 0.00085 19.2 0.0 1.5 1 1 0 1 1 1 1 Orthopoxvirus A5L protein-like UBA PF00627.26 ESA09346.1 - 0.045 13.5 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain BBS2_C PF14782.1 ESA09346.1 - 0.061 11.8 2.1 0.081 11.4 1.5 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal MTBP_C PF14920.1 ESA09346.1 - 0.71 9.3 11.0 1 8.8 7.6 1.1 1 0 0 1 1 1 0 MDM2-binding DUF4603 PF15376.1 ESA09346.1 - 3.7 4.6 13.0 4.5 4.3 9.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF2733 PF10813.3 ESA09349.1 - 0.083 12.4 0.1 6.2 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2733) DUF648 PF04890.8 ESA09350.1 - 0.0085 15.3 2.5 0.0096 15.1 1.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF648) Xpo1 PF08389.7 ESA09350.1 - 0.096 12.5 0.9 0.13 12.2 0.6 1.2 1 0 0 1 1 1 0 Exportin 1-like protein DUF3333 PF11812.3 ESA09350.1 - 0.1 12.6 1.0 0.12 12.4 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) FokI_N PF02981.10 ESA09350.1 - 0.23 11.0 1.2 0.25 10.9 0.9 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, recognition domain SPAN-X PF07458.7 ESA09350.1 - 0.63 10.3 5.2 0.93 9.7 3.6 1.3 1 0 0 1 1 1 0 Sperm protein associated with nucleus, mapped to X chromosome FAM183 PF14886.1 ESA09350.1 - 0.73 10.3 5.4 0.93 10.0 3.8 1.2 1 0 0 1 1 1 0 FAM183A and FAM183B related Aldo_ket_red PF00248.16 ESA09352.1 - 1.9e-28 99.1 0.0 2.1e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Peptidase_S9 PF00326.16 ESA09353.1 - 2.9e-50 170.4 0.0 4.2e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.16 ESA09353.1 - 9.3e-21 73.7 0.0 1.4e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_5 PF12695.2 ESA09353.1 - 3.6e-09 36.5 0.0 6.3e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESA09353.1 - 5.5e-09 35.8 0.1 1.7e-08 34.2 0.0 1.7 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.2 ESA09353.1 - 1.2e-08 35.0 0.0 2.1e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 ESA09353.1 - 6e-06 25.8 0.1 2e-05 24.1 0.1 1.7 1 1 0 1 1 1 1 Putative esterase DLH PF01738.13 ESA09353.1 - 0.00044 19.6 0.1 0.046 13.0 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 ESA09353.1 - 0.00094 18.7 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.4 ESA09353.1 - 0.0041 16.4 0.0 0.012 14.8 0.0 1.7 1 1 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_3 PF07859.8 ESA09353.1 - 0.0086 15.6 0.0 0.018 14.6 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESA09353.1 - 0.011 15.1 0.3 1.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Lact_bio_phlase PF09508.5 ESA09353.1 - 0.012 13.3 0.3 0.025 12.2 0.0 1.5 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase Peptidase_S28 PF05577.7 ESA09353.1 - 0.026 13.1 0.0 0.034 12.7 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 AXE1 PF05448.7 ESA09353.1 - 0.029 12.8 0.0 0.13 10.7 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Pkinase_Tyr PF07714.12 ESA09355.1 - 0.00096 18.2 0.1 0.0043 16.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09355.1 - 0.0015 17.7 0.2 0.0042 16.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Protocadherin PF08374.6 ESA09356.1 - 0.1 12.2 1.0 0.12 11.9 0.7 1.1 1 0 0 1 1 1 0 Protocadherin ArgK PF03308.11 ESA09358.1 - 2.1e-92 308.6 0.0 2.6e-92 308.3 0.0 1.1 1 0 0 1 1 1 1 ArgK protein cobW PF02492.14 ESA09358.1 - 2.2e-09 37.0 0.0 4.3e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.18 ESA09358.1 - 3.2e-05 23.4 0.0 5.6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 ESA09358.1 - 0.00087 18.8 0.1 0.0021 17.5 0.1 1.8 1 1 0 1 1 1 1 AAA-like domain ATP_bind_1 PF03029.12 ESA09358.1 - 0.00093 18.7 0.1 0.0035 16.9 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MobB PF03205.9 ESA09358.1 - 0.0013 18.4 0.0 0.009 15.7 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 ESA09358.1 - 0.0026 18.5 0.5 0.013 16.3 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESA09358.1 - 0.011 15.6 0.0 0.03 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ESA09358.1 - 0.011 15.3 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_22 PF13401.1 ESA09358.1 - 0.025 14.7 0.1 0.16 12.0 0.0 2.3 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.17 ESA09358.1 - 0.025 14.0 0.0 0.14 11.5 0.0 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.1 ESA09358.1 - 0.042 13.4 0.0 0.11 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA09358.1 - 0.046 13.7 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 ESA09358.1 - 0.073 13.2 0.0 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ProQ PF04352.8 ESA09358.1 - 0.089 12.4 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 ProQ/FINO family IstB_IS21 PF01695.12 ESA09358.1 - 0.089 12.2 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESA09358.1 - 0.11 12.8 3.9 0.13 12.5 0.0 2.8 3 1 0 3 3 3 0 AAA domain Pkinase PF00069.20 ESA09360.1 - 7.5e-42 143.2 0.7 1e-41 142.8 0.3 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09360.1 - 4.6e-38 130.7 0.3 2.3e-36 125.2 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA09360.1 - 0.0017 17.7 1.5 0.0062 15.9 0.1 2.2 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ESA09360.1 - 0.0025 17.5 0.0 0.0082 15.8 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA09360.1 - 0.066 12.4 0.1 0.066 12.4 0.1 2.3 2 1 0 3 3 3 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA09360.1 - 0.076 12.0 0.1 0.16 10.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_7 PF13499.1 ESA09361.1 - 0.092 12.8 2.4 3.9 7.6 0.1 2.9 2 0 0 2 2 2 0 EF-hand domain pair Eaf7 PF07904.8 ESA09362.1 - 0.011 15.6 3.0 0.011 15.6 2.1 1.9 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 LRR_5 PF13306.1 ESA09362.1 - 0.024 14.3 1.4 0.032 13.9 0.5 1.4 1 1 0 1 1 1 0 Leucine rich repeats (6 copies) HPD PF05044.7 ESA09362.1 - 0.046 13.3 2.3 0.79 9.3 0.5 2.1 1 1 1 2 2 2 0 Homeo-prospero domain Adaptin_binding PF10199.4 ESA09362.1 - 0.14 12.4 2.3 0.11 12.7 0.9 1.4 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF2458 PF10454.4 ESA09363.1 - 0.0074 16.1 3.2 0.0099 15.7 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) CDC37_N PF03234.9 ESA09363.1 - 0.0094 16.2 2.9 0.0097 16.2 2.0 1.1 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding Imm22 PF15592.1 ESA09363.1 - 0.011 16.0 1.1 0.026 14.8 0.2 1.7 1 1 1 2 2 2 0 Immunity protein 22 Virulence_RhuM PF13310.1 ESA09363.1 - 0.025 13.6 0.4 0.03 13.3 0.3 1.1 1 0 0 1 1 1 0 Virulence protein RhuM family Anp1 PF03452.9 ESA09363.1 - 0.028 13.5 0.2 0.028 13.5 0.2 1.0 1 0 0 1 1 1 0 Anp1 TBPIP PF07106.8 ESA09363.1 - 0.036 13.6 4.2 0.042 13.3 2.9 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4071 PF13281.1 ESA09363.1 - 0.047 12.5 1.0 0.053 12.3 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) DUF3829 PF12889.2 ESA09363.1 - 0.055 12.6 2.0 0.061 12.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Baculo_PEP_C PF04513.7 ESA09363.1 - 0.066 13.0 0.1 0.073 12.8 0.0 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus UxuA PF03786.8 ESA09363.1 - 0.087 11.3 0.9 0.091 11.2 0.6 1.0 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) SurA_N_3 PF13624.1 ESA09363.1 - 0.11 12.4 0.7 0.13 12.2 0.5 1.2 1 0 0 1 1 1 0 SurA N-terminal domain MSA-2c PF12238.3 ESA09363.1 - 0.16 11.5 0.9 0.19 11.3 0.6 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c YopJ PF03421.11 ESA09363.1 - 0.17 11.7 1.1 0.19 11.5 0.7 1.0 1 0 0 1 1 1 0 YopJ Serine/Threonine acetyltransferase Ribosomal_L29 PF00831.18 ESA09363.1 - 0.25 11.0 5.6 0.46 10.2 3.9 1.5 1 0 0 1 1 1 0 Ribosomal L29 protein TBCA PF02970.11 ESA09363.1 - 0.37 10.8 3.5 1.9 8.6 2.5 1.9 1 1 0 1 1 1 0 Tubulin binding cofactor A CENP-F_leu_zip PF10473.4 ESA09363.1 - 0.56 10.0 9.3 3.2 7.6 1.5 2.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Uso1_p115_C PF04871.8 ESA09363.1 - 0.57 10.1 5.6 0.68 9.8 3.9 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cauli_AT PF03233.8 ESA09363.1 - 0.69 9.5 4.8 0.84 9.3 3.4 1.1 1 0 0 1 1 1 0 Aphid transmission protein Prefoldin PF02996.12 ESA09363.1 - 0.96 9.1 4.9 0.46 10.1 0.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit IncA PF04156.9 ESA09363.1 - 1.2 8.7 5.9 1.8 8.1 4.1 1.3 1 1 0 1 1 1 0 IncA protein HR1 PF02185.11 ESA09363.1 - 1.3 8.8 6.3 0.38 10.5 0.8 2.1 1 1 0 1 1 1 0 Hr1 repeat PhoU PF01895.14 ESA09363.1 - 1.5 9.3 5.5 2.3 8.7 3.0 1.8 1 1 1 2 2 2 0 PhoU domain TPT PF03151.11 ESA09364.1 - 1.2e-12 47.7 9.1 1.2e-12 47.7 6.3 2.0 1 1 1 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 ESA09364.1 - 2.8e-12 46.1 13.2 3.4e-12 45.9 9.1 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESA09364.1 - 0.0038 17.2 3.2 0.0038 17.2 2.2 2.2 2 0 0 2 2 2 1 EamA-like transporter family PHO4 PF01384.15 ESA09364.1 - 0.061 11.9 8.6 0.11 11.0 4.5 2.2 1 1 0 1 1 1 0 Phosphate transporter family CENP-L PF13092.1 ESA09364.1 - 0.071 12.8 0.3 0.14 11.9 0.1 1.5 1 1 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 Ubiquitin_2 PF14560.1 ESA09365.1 - 1.2e-05 25.4 0.4 1.3e-05 25.3 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 ESA09365.1 - 0.00038 19.8 1.0 0.56 9.6 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin family UN_NPL4 PF11543.3 ESA09365.1 - 0.04 14.1 0.2 0.048 13.9 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 DUF2222 PF09984.4 ESA09365.1 - 0.07 12.5 0.1 0.071 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized signal transduction histidine kinase domain (DUF2222) Lipase_3 PF01764.20 ESA09367.1 - 1.5e-34 118.5 0.0 2e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA09367.1 - 0.0024 17.6 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ESA09367.1 - 0.0059 15.9 0.0 0.0081 15.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 ESA09367.1 - 0.0077 16.1 0.0 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 ESA09367.1 - 0.015 14.7 0.0 0.072 12.4 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Thioesterase PF00975.15 ESA09367.1 - 0.051 13.7 0.0 0.062 13.5 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Pkinase PF00069.20 ESA09368.1 - 6.3e-10 38.6 0.2 2.9e-08 33.1 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09368.1 - 3.4e-09 36.1 0.1 4.3e-08 32.5 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA09369.1 - 5e-11 42.1 0.0 5e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09369.1 - 2.6e-07 30.0 0.0 2.7e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Tubulin_C PF03953.12 ESA09370.1 - 0.042 13.8 0.2 0.042 13.8 0.2 2.3 3 0 0 3 3 3 0 Tubulin C-terminal domain Ca_hom_mod PF14798.1 ESA09370.1 - 0.05 12.5 0.1 0.091 11.7 0.1 1.3 1 0 0 1 1 1 0 Calcium homeostasis modulator UDPGT PF00201.13 ESA09371.1 - 0.00017 20.3 0.0 0.0002 20.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Tubulin_C PF03953.12 ESA09372.1 - 0.0025 17.8 0.1 0.0025 17.8 0.1 2.8 3 1 1 4 4 4 1 Tubulin C-terminal domain PPV_E2_C PF00511.12 ESA09372.1 - 0.03 14.2 0.1 13 5.7 0.0 2.9 2 0 0 2 2 2 0 E2 (early) protein, C terminal Sel1 PF08238.7 ESA09373.1 - 3.9e-14 52.7 8.9 3.2e-05 24.4 0.0 5.4 6 0 0 6 6 6 3 Sel1 repeat DUF669 PF05037.8 ESA09373.1 - 2.7 7.8 9.8 2.5 8.0 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF669) Mit_KHE1 PF10173.4 ESA09373.1 - 6.4 6.5 8.7 0.14 12.0 0.3 2.3 2 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related BTB PF00651.26 ESA09374.1 - 1.2e-05 25.2 0.0 1.4e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF2577 PF10844.3 ESA09375.1 - 0.062 13.3 0.8 3.2 7.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2577) AAA_12 PF13087.1 ESA09376.1 - 3.7e-36 124.3 1.6 7.7e-36 123.3 1.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA09376.1 - 2.1e-18 66.7 0.8 3.5e-17 62.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain zf-4CXXC_R1 PF10497.4 ESA09377.1 - 5e-34 116.5 9.2 6.4e-34 116.2 6.4 1.1 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 N-glycanase_N PF09112.5 ESA09378.1 - 0.059 12.7 0.1 0.07 12.4 0.1 1.3 1 1 0 1 1 1 0 Peptide-N-glycosidase F, N terminal Pkinase_Tyr PF07714.12 ESA09379.1 - 5.8e-30 104.2 10.6 5.7e-09 35.4 0.0 10.1 8 2 2 10 10 10 6 Protein tyrosine kinase SpoU_methylas_C PF12105.3 ESA09379.1 - 0.0042 16.5 6.4 42 3.7 0.0 7.0 8 0 0 8 8 8 1 SpoU, rRNA methylase, C-terminal DUF1713 PF08213.6 ESA09379.1 - 0.19 11.3 1.2 22 4.7 0.1 2.8 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1713) Peptidase_M56 PF05569.6 ESA09380.1 - 0.0024 16.9 1.9 0.005 15.8 1.3 1.5 1 0 0 1 1 1 1 BlaR1 peptidase M56 COesterase PF00135.23 ESA09381.1 - 1.7e-07 30.3 0.0 4.4e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_5 PF12695.2 ESA09381.1 - 1e-05 25.2 0.0 2e-05 24.4 0.0 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESA09381.1 - 0.0029 17.2 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 ESA09381.1 - 0.029 13.2 0.1 0.048 12.5 0.1 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DSBA PF01323.15 ESA09382.1 - 3.5e-31 108.2 0.2 8.4e-27 93.9 0.0 2.2 2 0 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.1 ESA09382.1 - 5.7e-06 26.4 0.1 0.00025 21.1 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.1 ESA09382.1 - 0.069 12.9 0.1 0.4 10.5 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin domain ABC2_membrane_3 PF12698.2 ESA09383.1 - 0.091 11.7 2.3 0.16 10.9 1.6 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Pkinase_Tyr PF07714.12 ESA09384.1 - 8.4e-06 25.0 0.0 1.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09384.1 - 0.0015 17.7 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09386.1 - 9.5e-35 119.9 0.0 2.2e-24 85.9 0.0 5.9 6 1 1 7 7 7 2 Protein tyrosine kinase Pkinase PF00069.20 ESA09386.1 - 4.9e-34 117.6 0.1 1.4e-31 109.5 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain BCS1_N PF08740.6 ESA09386.1 - 1.7e-12 47.3 0.5 0.94 9.0 0.0 6.3 6 0 0 6 6 6 5 BCS1 N terminal DUF4413 PF14372.1 ESA09386.1 - 9e-06 25.6 16.4 0.32 10.9 0.2 6.3 6 0 0 6 6 6 3 Domain of unknown function (DUF4413) zinc_ribbon_2 PF13240.1 ESA09386.1 - 3.6e-05 23.0 16.4 1.5 8.3 0.4 5.8 5 0 0 5 5 5 4 zinc-ribbon domain DUF1811 PF08838.5 ESA09386.1 - 0.003 17.4 9.8 0.51 10.3 0.1 4.1 4 0 0 4 4 4 2 Protein of unknown function (DUF1811) APH PF01636.18 ESA09386.1 - 0.6 9.7 0.2 0.99 9.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA09387.1 - 1.1e-07 31.2 0.0 1.1e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.15 ESA09387.1 - 0.00028 20.5 0.1 0.00036 20.1 0.1 1.3 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA09387.1 - 0.0037 17.0 0.0 0.0037 17.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA09387.1 - 0.0051 16.1 0.0 0.0054 16.0 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 ESA09387.1 - 0.0053 15.8 0.0 0.0053 15.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA09387.1 - 0.017 14.1 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1542 PF07564.6 ESA09389.1 - 0.0054 16.7 1.5 0.0079 16.1 0.7 1.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA09389.1 - 0.053 13.3 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 HELP PF03451.9 ESA09390.1 - 0.0026 17.2 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 HELP motif HELP PF03451.9 ESA09391.1 - 0.0033 16.9 0.0 0.0041 16.6 0.0 1.2 1 0 0 1 1 1 1 HELP motif Glyco_hydro_cc PF11790.3 ESA09391.1 - 0.0095 15.3 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DZR PF12773.2 ESA09392.1 - 0.00017 21.3 16.3 0.024 14.4 0.5 3.4 3 0 0 3 3 3 3 Double zinc ribbon DUF4413 PF14372.1 ESA09392.1 - 0.052 13.5 8.3 0.85 9.6 0.3 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) DUF3727 PF12527.3 ESA09392.1 - 0.37 10.9 3.3 19 5.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3727) DnaJ_CXXCXGXG PF00684.14 ESA09392.1 - 0.46 10.5 13.6 4.9 7.2 0.6 3.4 3 0 0 3 3 3 0 DnaJ central domain TraT PF05818.7 ESA09392.1 - 0.52 9.7 3.2 1.3 8.3 0.1 2.5 3 0 0 3 3 3 0 Enterobacterial TraT complement resistance protein zf-ribbon_3 PF13248.1 ESA09392.1 - 0.61 9.3 15.8 0.59 9.4 1.9 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Ldh_2 PF02615.9 ESA09392.1 - 0.9 8.1 2.7 1.1 7.9 0.1 2.2 3 0 0 3 3 3 0 Malate/L-lactate dehydrogenase DUF1925 PF09094.6 ESA09392.1 - 1.1 9.2 6.6 9 6.3 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) zinc_ribbon_2 PF13240.1 ESA09392.1 - 8.5 6.0 17.5 5.2 6.6 3.0 3.6 3 0 0 3 3 3 0 zinc-ribbon domain TSGP1 PF07771.6 ESA09394.1 - 0.05 13.4 1.7 0.059 13.2 1.2 1.1 1 0 0 1 1 1 0 Tick salivary peptide group 1 Syntaxin-6_N PF09177.6 ESA09394.1 - 0.056 13.8 0.1 0.063 13.6 0.1 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal zf-H2C2_5 PF13909.1 ESA09394.1 - 0.18 12.1 4.9 3.1 8.2 0.0 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-BED PF02892.10 ESA09394.1 - 2.8 7.7 9.5 1.8 8.4 0.9 2.3 2 0 0 2 2 2 0 BED zinc finger Frataxin_Cyay PF01491.11 ESA09395.1 - 0.02 14.6 2.9 0.33 10.7 0.1 3.5 3 2 1 4 4 4 0 Frataxin-like domain PA14_2 PF10528.4 ESA09395.1 - 0.11 12.4 8.1 4.5 7.2 0.1 3.2 2 1 0 3 3 3 0 GLEYA domain Thioredoxin_2 PF13098.1 ESA09395.1 - 0.69 10.1 3.7 3.8 7.7 0.2 2.7 2 1 0 2 2 2 0 Thioredoxin-like domain ORF11CD3 PF10549.4 ESA09395.1 - 1.5 8.6 4.5 5.9 6.7 0.4 2.7 2 0 0 2 2 2 0 ORF11CD3 domain HypA PF01155.14 ESA09395.1 - 1.9 8.1 5.6 1.7 8.3 1.4 2.4 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF4215 PF13948.1 ESA09395.1 - 5.3 7.3 19.8 0.41 10.9 1.7 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4215) Pkinase_Tyr PF07714.12 ESA09396.1 - 2.4e-30 105.4 0.1 3.5e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09396.1 - 3.5e-30 105.0 1.7 8.7e-30 103.7 1.2 1.6 1 1 0 1 1 1 1 Protein kinase domain PsbU PF06514.6 ESA09396.1 - 0.041 13.7 0.2 0.43 10.4 0.0 2.7 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) p450 PF00067.17 ESA09397.1 - 1.9e-07 29.9 0.0 2.5e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IncA PF04156.9 ESA09398.1 - 0.14 11.7 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 IncA protein Med1 PF10744.4 ESA09398.1 - 0.38 9.4 7.6 0.47 9.1 5.3 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 Methyltransf_23 PF13489.1 ESA09399.1 - 1.3e-13 50.9 0.0 2e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA09399.1 - 1.4e-13 51.1 0.0 2.8e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA09399.1 - 3.5e-12 46.1 0.1 2.1e-11 43.6 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA09399.1 - 5.3e-09 36.6 0.0 3.2e-08 34.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA09399.1 - 1.2e-08 35.2 0.0 2.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA09399.1 - 2.5e-08 33.1 0.0 6e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA09399.1 - 5.7e-07 29.9 0.0 1.1e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA09399.1 - 1.6e-06 27.3 0.0 4.4e-06 25.9 0.0 1.7 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 ESA09399.1 - 0.0001 22.3 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA09399.1 - 0.0002 20.7 0.0 0.00035 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 ESA09399.1 - 0.00058 19.2 0.0 0.00099 18.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 ESA09399.1 - 0.00083 19.3 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ESA09399.1 - 0.0022 17.2 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase CMAS PF02353.15 ESA09399.1 - 0.018 14.1 0.0 0.033 13.2 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.8 ESA09399.1 - 0.063 12.3 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2490 PF10677.4 ESA09400.1 - 0.13 11.5 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) Alpha_E3_glycop PF01563.11 ESA09400.1 - 0.22 11.3 0.8 0.37 10.6 0.0 1.8 2 0 0 2 2 2 0 Alphavirus E3 glycoprotein BTB PF00651.26 ESA09401.1 - 5.9e-19 68.1 0.3 3e-18 65.8 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA09401.1 - 1.7e-11 44.3 7.4 4e-11 43.0 5.1 1.7 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA09401.1 - 1.3e-07 31.3 0.0 7.7e-06 25.6 0.0 3.1 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF508 PF04370.7 ESA09402.1 - 0.15 11.6 3.7 0.31 10.6 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF508) zf-DHHC PF01529.15 ESA09403.1 - 1.1 8.6 5.0 2.1 7.6 3.5 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase MPP6 PF10175.4 ESA09404.1 - 0.0043 17.3 0.3 0.0046 17.3 0.2 1.1 1 0 0 1 1 1 1 M-phase phosphoprotein 6 SLEI_Leptospira PF07620.6 ESA09404.1 - 0.031 14.0 0.4 0.067 13.0 0.3 1.6 1 0 0 1 1 1 0 SLEI Pkinase_Tyr PF07714.12 ESA09405.1 - 2.5e-39 134.9 0.2 1e-35 123.0 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA09405.1 - 4.4e-36 124.3 3.6 9.8e-36 123.2 0.1 2.7 3 0 0 3 3 3 1 Protein kinase domain APH PF01636.18 ESA09405.1 - 0.069 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA09407.1 - 4e-10 39.2 2.1 1.1e-09 37.8 1.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA09407.1 - 5.8e-09 35.3 0.7 1.6e-08 34.0 0.5 1.8 1 0 0 1 1 1 1 F-box domain WD40 PF00400.27 ESA09407.1 - 8.3e-05 22.3 0.4 0.017 15.0 0.0 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat HSP70 PF00012.15 ESA09411.1 - 3.4e-05 21.9 0.0 0.00078 17.4 0.0 2.6 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESA09411.1 - 8e-05 21.3 0.0 0.27 9.8 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein P5-ATPase PF12409.3 ESA09412.1 - 0.18 11.6 1.0 0.2 11.4 0.7 1.1 1 0 0 1 1 1 0 P5-type ATPase cation transporter Sel1 PF08238.7 ESA09414.1 - 4.7e-58 192.3 23.3 3.7e-10 40.1 1.6 7.1 6 1 1 7 7 7 6 Sel1 repeat TPR_11 PF13414.1 ESA09414.1 - 5e-05 22.8 28.1 0.02 14.5 2.7 5.9 1 1 5 6 6 6 5 TPR repeat MIT PF04212.13 ESA09414.1 - 0.0016 18.2 17.6 0.55 10.1 0.3 5.5 3 3 2 5 5 5 3 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA09414.1 - 0.0088 16.1 0.3 0.78 9.8 0.0 3.0 2 1 1 3 3 3 1 Predicted AdoMet-dependent methyltransferase Exo_endo_phos_2 PF14529.1 ESA09414.1 - 0.059 12.9 0.1 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase FTCD_N PF07837.7 ESA09414.1 - 0.066 12.7 0.2 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Formiminotransferase domain, N-terminal subdomain EF-hand_10 PF14788.1 ESA09414.1 - 0.19 11.4 3.5 20 4.9 0.1 4.4 6 0 0 6 6 6 0 EF hand TPR_7 PF13176.1 ESA09414.1 - 0.34 10.8 6.2 11 6.0 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA09414.1 - 8.4 6.5 33.9 2.2 8.4 0.2 9.3 10 2 1 11 11 11 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA09415.1 - 1.3e-41 140.0 15.9 2.8e-10 40.5 0.2 5.9 6 0 0 6 6 6 5 Sel1 repeat TPR_7 PF13176.1 ESA09415.1 - 0.02 14.6 0.3 1.8 8.5 0.0 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat G10 PF01125.12 ESA09415.1 - 0.048 13.2 0.1 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 G10 protein MIT PF04212.13 ESA09415.1 - 0.12 12.3 12.9 4.7 7.1 0.0 4.8 3 1 3 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA09415.1 - 0.27 11.1 6.1 15 5.5 0.0 4.3 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA09415.1 - 0.62 10.6 3.6 49 4.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Kelch_5 PF13854.1 ESA09417.1 - 0.00012 21.9 0.2 0.075 13.0 0.0 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESA09417.1 - 0.003 17.2 6.9 0.029 14.1 0.0 4.2 3 2 1 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09417.1 - 0.0049 16.9 0.6 4.6 7.5 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.1 ESA09417.1 - 0.024 14.8 7.7 0.13 12.4 0.0 3.9 4 1 0 4 4 4 0 Galactose oxidase, central domain MtrB PF05440.7 ESA09417.1 - 0.061 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Kelch_2 PF07646.10 ESA09417.1 - 0.12 12.1 0.1 1.6 8.6 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.20 ESA09417.1 - 0.31 10.6 8.3 4.3 6.9 0.4 3.8 4 0 0 4 4 4 0 Kelch motif U-box PF04564.10 ESA09418.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 U-box domain Pkinase_Tyr PF07714.12 ESA09418.1 - 0.12 11.3 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Sel1 PF08238.7 ESA09419.1 - 6.3e-13 48.9 2.3 2.2e-12 47.1 0.5 1.9 2 0 0 2 2 2 1 Sel1 repeat TPR_6 PF13174.1 ESA09419.1 - 0.032 14.6 0.1 0.059 13.8 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA09419.1 - 0.75 9.5 3.7 9.7 5.9 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat BTB_2 PF02214.17 ESA09420.1 - 1.1e-18 67.2 0.3 3.3e-18 65.6 0.2 1.8 1 1 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.17 ESA09421.1 - 5.4e-15 55.3 0.8 1.8e-13 50.5 0.6 2.7 1 1 0 1 1 1 1 BTB/POZ domain DUF1363 PF07101.6 ESA09422.1 - 0.083 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1363) TORC_C PF12886.2 ESA09426.1 - 0.39 10.9 1.7 5.1 7.3 0.1 2.4 1 1 1 2 2 2 0 Transducer of regulated CREB activity, C terminus Competence PF03772.11 ESA09427.1 - 0.012 14.6 3.9 0.015 14.3 2.7 1.1 1 0 0 1 1 1 0 Competence protein TMCO5 PF14992.1 ESA09427.1 - 0.53 9.3 4.0 0.43 9.6 2.2 1.4 1 1 0 1 1 1 0 TMCO5 family DUF1774 PF08611.5 ESA09427.1 - 2.6 8.2 5.2 3.8 7.7 3.3 1.5 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF1774) ABC2_membrane PF01061.19 ESA09429.1 - 2.9e-22 78.8 12.1 4.5e-22 78.2 8.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 ESA09429.1 - 5.4e-08 32.2 9.6 6.5e-08 31.9 6.7 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 ESA09429.1 - 2e-05 23.6 5.3 2.5e-05 23.3 3.7 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF4044 PF13253.1 ESA09429.1 - 0.15 11.2 0.8 0.31 10.2 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) HMG_box PF00505.14 ESA09430.1 - 2.3e-10 40.6 0.6 4.5e-10 39.6 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09430.1 - 1.8e-07 31.4 0.5 1.8e-07 31.4 0.3 1.6 2 0 0 2 2 2 1 HMG-box domain YABBY PF04690.8 ESA09430.1 - 0.004 17.4 2.6 0.0046 17.2 1.8 1.0 1 0 0 1 1 1 1 YABBY protein Pirin PF02678.11 ESA09432.1 - 4.8e-32 110.0 0.2 8.4e-32 109.2 0.1 1.4 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.6 ESA09432.1 - 4.3e-07 29.3 1.4 4.2e-06 26.1 0.2 2.3 2 0 0 2 2 2 1 Cupin domain Arch_ATPase PF01637.13 ESA09433.1 - 3.3e-09 36.7 3.1 3.3e-09 36.7 2.1 2.3 1 1 1 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 ESA09433.1 - 1.8e-07 31.3 0.2 5.2e-07 29.8 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 ESA09433.1 - 7.7e-07 29.3 0.0 1.7e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA09433.1 - 0.00016 21.7 0.0 0.00082 19.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 ESA09433.1 - 0.00018 21.9 0.1 0.0005 20.5 0.1 1.8 1 1 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 ESA09433.1 - 0.0008 19.3 0.8 0.0093 15.8 0.6 2.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA09433.1 - 0.0013 19.5 0.2 0.0056 17.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 ESA09433.1 - 0.0099 14.7 1.2 0.028 13.2 0.8 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.1 ESA09433.1 - 0.011 15.5 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 ESA09433.1 - 0.014 14.2 0.1 0.036 13.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.1 ESA09433.1 - 0.041 14.1 0.2 0.041 14.1 0.2 2.6 1 1 1 2 2 2 0 AAA domain T2SE PF00437.15 ESA09433.1 - 0.056 12.3 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF258 PF03193.11 ESA09433.1 - 0.059 12.5 0.0 0.39 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DEAD PF00270.24 ESA09433.1 - 0.092 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase ABC_tran PF00005.22 ESA09433.1 - 0.13 12.5 2.0 0.29 11.4 1.4 1.9 1 1 0 1 1 1 0 ABC transporter AAA_19 PF13245.1 ESA09433.1 - 0.14 11.9 0.0 3.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain Cullin PF00888.17 ESA09434.1 - 4.6e-29 101.4 0.2 5e-29 101.2 0.1 1.0 1 0 0 1 1 1 1 Cullin family Rrf2 PF02082.15 ESA09434.1 - 0.078 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator F-box-like PF12937.2 ESA09435.1 - 8.7e-12 44.5 0.2 2e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA09435.1 - 0.0031 17.1 0.0 0.011 15.3 0.0 1.9 1 0 0 1 1 1 1 F-box domain Tnp_P_element PF12017.3 ESA09436.1 - 0.16 11.1 0.5 0.23 10.6 0.4 1.2 1 0 0 1 1 1 0 Transposase protein DUF4298 PF14131.1 ESA09436.1 - 0.2 11.5 1.4 0.39 10.6 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) Cytochrom_B562 PF07361.6 ESA09436.1 - 0.25 11.7 2.0 0.53 10.7 1.4 1.6 1 1 0 1 1 1 0 Cytochrome b562 RFC1 PF08519.7 ESA09441.1 - 1.5e-33 115.7 2.1 3e-31 108.2 0.0 3.1 3 0 0 3 3 3 1 Replication factor RFC1 C terminal domain BRCT PF00533.21 ESA09441.1 - 5.6e-17 61.6 0.0 1.7e-16 60.1 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.24 ESA09441.1 - 9.8e-12 45.2 1.1 2.8e-11 43.7 0.1 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESA09441.1 - 1.3e-10 40.6 0.7 3.9e-10 39.0 0.5 1.8 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESA09441.1 - 1.8e-05 24.9 0.1 4.6e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESA09441.1 - 0.0001 21.4 0.0 0.00033 19.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus DNA_pol3_delta PF06144.8 ESA09441.1 - 0.00072 19.1 1.2 0.0039 16.7 0.2 2.5 2 0 0 2 2 2 1 DNA polymerase III, delta subunit PTCB-BRCT PF12738.2 ESA09441.1 - 0.0013 18.5 0.0 0.0035 17.1 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain ARL2_Bind_BART PF11527.3 ESA09441.1 - 0.0042 16.8 0.4 0.0042 16.8 0.2 1.9 2 0 0 2 2 2 1 The ARF-like 2 binding protein BART Sigma54_activ_2 PF14532.1 ESA09441.1 - 0.0098 15.9 0.0 0.07 13.1 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 ESA09441.1 - 0.017 14.2 0.0 0.04 13.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Pneumo_matrix PF03393.11 ESA09441.1 - 0.033 13.1 0.2 0.11 11.4 0.0 1.8 2 0 0 2 2 2 0 Pneumovirus matrix protein Miro PF08477.8 ESA09441.1 - 0.034 14.6 1.4 0.21 12.0 0.2 2.5 2 0 0 2 2 2 0 Miro-like protein AAA_16 PF13191.1 ESA09441.1 - 0.038 13.9 0.0 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 ESA09441.1 - 0.045 13.6 0.0 0.18 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESA09441.1 - 0.12 12.0 3.4 5.3 6.7 0.0 2.7 2 1 1 3 3 3 0 NTPase bZIP_1 PF00170.16 ESA09443.1 - 2.4e-06 27.3 13.0 1.2e-05 25.1 9.0 2.0 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ESA09443.1 - 2.7e-06 27.1 14.2 6.6e-06 25.8 9.8 1.7 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 ESA09443.1 - 0.013 15.7 7.1 0.013 15.7 4.9 1.6 1 1 0 1 1 1 0 bZIP Maf transcription factor SR-25 PF10500.4 ESA09443.1 - 0.02 14.3 9.7 0.021 14.3 6.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Phlebovirus_NSM PF07246.6 ESA09443.1 - 0.039 13.1 13.1 0.061 12.4 9.1 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF4200 PF13863.1 ESA09443.1 - 0.042 13.8 10.8 0.059 13.3 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Corona_S2 PF01601.11 ESA09443.1 - 0.36 8.8 2.8 0.42 8.6 1.9 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Endonuc_Holl PF10107.4 ESA09443.1 - 0.4 10.3 4.9 0.49 10.0 3.4 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase SOBP PF15279.1 ESA09443.1 - 0.56 10.5 4.0 0.63 10.3 2.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein DivIC PF04977.10 ESA09443.1 - 0.97 8.9 7.0 3.6 7.1 4.8 2.1 1 1 0 1 1 1 0 Septum formation initiator Fib_alpha PF08702.5 ESA09443.1 - 1.4 9.0 13.3 1.7 8.7 9.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PspB PF06667.7 ESA09443.1 - 1.7 8.6 5.7 0.69 9.8 1.8 1.9 1 1 1 2 2 2 0 Phage shock protein B DUF1664 PF07889.7 ESA09443.1 - 1.9 8.2 6.6 2.2 8.1 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) TLD PF07534.11 ESA09444.1 - 3.8e-11 43.1 6.0 7.5e-10 38.9 2.5 2.5 2 0 0 2 2 2 2 TLD BTB PF00651.26 ESA09444.1 - 5.4e-11 42.4 0.0 1.6e-10 40.9 0.0 1.8 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA09444.1 - 9e-08 31.8 0.7 1e-05 25.2 0.2 2.9 2 1 0 2 2 2 1 BTB And C-terminal Kelch bZIP_1 PF00170.16 ESA09445.1 - 4.1e-07 29.8 11.7 9.5e-07 28.6 8.1 1.6 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ESA09445.1 - 5.5e-06 26.1 10.6 9.8e-06 25.3 7.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper SR-25 PF10500.4 ESA09445.1 - 0.0019 17.7 11.6 0.0024 17.4 8.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein bZIP_Maf PF03131.12 ESA09445.1 - 0.037 14.3 5.2 0.037 14.3 3.6 1.5 2 0 0 2 2 2 0 bZIP Maf transcription factor V1R PF03402.9 ESA09445.1 - 0.039 13.3 0.3 0.045 13.1 0.2 1.1 1 0 0 1 1 1 0 Vomeronasal organ pheromone receptor family, V1R OKR_DC_1 PF01276.15 ESA09445.1 - 0.043 12.3 1.8 0.046 12.2 1.3 1.0 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain NinG PF05766.7 ESA09445.1 - 0.28 10.9 5.2 0.33 10.6 3.6 1.2 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein DUF663 PF04950.7 ESA09445.1 - 0.43 9.4 6.3 0.48 9.3 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF663) SOBP PF15279.1 ESA09445.1 - 0.65 10.3 5.0 0.74 10.1 3.5 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein Microtub_assoc PF07989.6 ESA09445.1 - 1.2 8.9 8.6 4.9 7.0 1.4 2.4 1 1 1 2 2 2 0 Microtubule associated AAA_22 PF13401.1 ESA09448.1 - 0.015 15.4 0.1 0.054 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain HMG_box PF00505.14 ESA09449.1 - 2.6e-05 24.3 0.1 4.5e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF2674 PF10879.3 ESA09450.1 - 0.0059 16.3 0.3 0.064 13.0 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2674) UBN2 PF14223.1 ESA09450.1 - 0.034 13.9 4.8 0.2 11.4 0.1 4.2 4 1 0 4 4 4 0 gag-polypeptide of LTR copia-type Pkinase_Tyr PF07714.12 ESA09451.1 - 2.8e-09 36.4 0.0 3.7e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09451.1 - 0.00028 20.1 0.0 0.00044 19.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Copper-bind PF00127.15 ESA09455.1 - 1.4e-06 28.4 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu_bind_like PF02298.12 ESA09455.1 - 0.0075 16.0 0.1 0.017 14.9 0.1 1.6 1 0 0 1 1 1 1 Plastocyanin-like domain Cu-oxidase_3 PF07732.10 ESA09455.1 - 0.01 15.5 0.0 0.027 14.2 0.0 1.8 1 0 0 1 1 1 0 Multicopper oxidase Cupredoxin_1 PF13473.1 ESA09455.1 - 0.03 14.2 0.0 0.055 13.3 0.0 1.4 1 0 0 1 1 1 0 Cupredoxin-like domain DUF928 PF06051.7 ESA09456.1 - 0.052 13.1 0.1 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Pkinase_Tyr PF07714.12 ESA09457.1 - 5.7e-06 25.5 0.0 8.4e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09457.1 - 0.00068 18.8 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DnaB_2 PF07261.6 ESA09457.1 - 0.0056 16.2 0.1 0.012 15.2 0.1 1.6 1 0 0 1 1 1 1 Replication initiation and membrane attachment DUF384 PF04064.8 ESA09457.1 - 0.085 12.4 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF384) Myb_DNA-bind_4 PF13837.1 ESA09458.1 - 3.8e-10 39.7 3.9 6.8e-10 38.9 2.7 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA09458.1 - 5.4e-05 23.0 5.5 0.00011 21.9 3.8 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA09458.1 - 0.0019 18.3 1.2 0.005 16.9 0.5 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_3 PF12776.2 ESA09458.1 - 0.0062 17.1 2.2 0.011 16.3 1.5 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain CCDC144C PF14915.1 ESA09458.1 - 0.024 13.5 0.3 0.04 12.8 0.2 1.3 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Myb_DNA-bind_6 PF13921.1 ESA09458.1 - 0.1 12.7 1.3 0.27 11.3 0.9 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain HSDR_N_2 PF13588.1 ESA09459.1 - 0.47 10.2 5.6 2.1 8.2 0.1 2.4 2 1 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase_Tyr PF07714.12 ESA09460.1 - 2.7e-38 131.5 0.0 3.6e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09460.1 - 7e-38 130.2 0.0 1.6e-37 129.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Ribosomal_L40e PF01020.12 ESA09460.1 - 0.0077 15.7 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L40e family APH PF01636.18 ESA09460.1 - 0.0097 15.6 0.2 0.035 13.8 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Imm6 PF14434.1 ESA09460.1 - 0.025 14.3 0.2 0.051 13.2 0.1 1.5 1 0 0 1 1 1 0 Immunity protein Imm6 DUF4064 PF13273.1 ESA09461.1 - 0.082 13.0 0.4 0.082 13.0 0.3 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) Ribosomal_S4e PF00900.15 ESA09463.1 - 7.6e-30 102.4 2.2 1e-29 102.0 0.6 1.9 2 0 0 2 2 2 1 Ribosomal family S4e S4 PF01479.20 ESA09463.1 - 5.1e-06 25.8 0.1 1.7e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 S4 domain KOW PF00467.24 ESA09463.1 - 1.8e-05 24.2 2.9 1.8e-05 24.2 2.0 2.6 3 0 0 3 3 3 1 KOW motif hSac2 PF12456.3 ESA09463.1 - 0.015 14.6 0.0 0.045 13.1 0.0 1.8 2 0 0 2 2 2 0 Inositol phosphatase UQ_con PF00179.21 ESA09464.1 - 2.4e-36 124.2 0.0 3.2e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme MFS_1 PF07690.11 ESA09466.1 - 4e-26 91.5 54.3 7.5e-12 44.6 3.3 3.5 2 2 1 4 4 4 3 Major Facilitator Superfamily Nuc_H_symport PF03825.11 ESA09466.1 - 2e-13 49.8 23.8 8.2e-12 44.5 6.2 2.3 2 0 0 2 2 2 2 Nucleoside H+ symporter MFS_1_like PF12832.2 ESA09466.1 - 1.4e-11 43.9 2.3 7.9e-11 41.5 1.6 2.4 1 0 0 1 1 1 1 MFS_1 like family LacY_symp PF01306.14 ESA09466.1 - 5.3e-07 28.5 5.9 5.3e-07 28.5 4.1 2.1 2 0 0 2 2 2 1 LacY proton/sugar symporter RIX1 PF08167.7 ESA09467.1 - 1.1e-36 126.0 9.6 1.1e-36 126.0 6.6 2.9 3 0 0 3 3 3 2 rRNA processing/ribosome biogenesis NUC202 PF08166.7 ESA09467.1 - 0.0034 17.2 1.2 1.4 8.8 0.1 2.7 2 0 0 2 2 2 2 NUC202 domain Ipi1_N PF12333.3 ESA09467.1 - 0.44 10.5 5.3 0.17 11.8 0.1 3.1 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Cut8_C PF08559.5 ESA09468.1 - 3.9e-27 94.8 1.1 5.2e-27 94.4 0.2 1.6 2 0 0 2 2 2 1 Cut8 six-helix bundle Cut8_M PF14483.1 ESA09468.1 - 9.3e-07 28.5 0.9 1.6e-06 27.7 0.6 1.4 1 0 0 1 1 1 1 Cut8 dimerisation domain Sel1 PF08238.7 ESA09470.1 - 2.6e-21 75.5 5.7 1.3e-08 35.1 0.2 4.0 4 0 0 4 4 4 4 Sel1 repeat Arrestin_C PF02752.17 ESA09472.1 - 3e-18 66.2 1.1 2.9e-15 56.5 0.6 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ESA09472.1 - 8.1e-15 54.9 0.1 8.6e-13 48.3 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 ESA09472.1 - 0.00034 20.1 0.0 0.00065 19.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like p450 PF00067.17 ESA09474.1 - 3.8e-86 289.4 3.5 4.2e-86 289.2 2.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 LAGLIDADG_1 PF00961.14 ESA09474.1 - 0.15 12.6 0.2 0.15 12.6 0.2 2.5 1 1 1 2 2 2 0 LAGLIDADG endonuclease Pkinase PF00069.20 ESA09475.1 - 1.4e-35 122.7 1.0 1.9e-35 122.2 0.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09475.1 - 6.1e-34 117.2 0.0 7.9e-34 116.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA09475.1 - 0.007 15.7 0.3 0.012 14.9 0.1 1.5 1 1 0 1 1 1 1 RIO1 family Pkinase PF00069.20 ESA09476.1 - 5.5e-72 242.0 0.0 6.2e-72 241.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09476.1 - 6.7e-35 120.4 0.1 8.2e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA09476.1 - 0.00011 21.3 0.1 0.00044 19.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 ESA09476.1 - 0.00025 20.8 0.0 0.0073 16.0 0.0 2.0 1 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA09476.1 - 0.0022 16.8 0.0 0.0036 16.1 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 ESA09476.1 - 0.016 14.2 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SPRY PF00622.23 ESA09478.1 - 4e-18 65.6 0.2 5.1e-18 65.3 0.1 1.1 1 0 0 1 1 1 1 SPRY domain DUF4636 PF15468.1 ESA09479.1 - 0.13 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Oxysterol_BP PF01237.13 ESA09480.1 - 3.3e-55 186.9 0.3 8.1e-55 185.7 0.2 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein Pkinase PF00069.20 ESA09481.1 - 1.3e-05 24.4 0.0 2.8e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09481.1 - 0.00035 19.7 0.0 0.001 18.2 0.0 1.7 1 1 1 2 2 2 2 Protein tyrosine kinase HMG_box PF00505.14 ESA09482.1 - 2.9e-09 37.0 0.1 4.6e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09482.1 - 0.013 15.8 0.1 0.023 15.0 0.1 1.4 1 0 0 1 1 1 0 HMG-box domain Baculo_PP31 PF05311.6 ESA09482.1 - 0.66 9.1 4.1 0.83 8.8 2.9 1.4 1 1 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) NTP_transf_2 PF01909.18 ESA09484.1 - 0.035 14.4 0.0 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 Nucleotidyltransferase domain Sel1 PF08238.7 ESA09486.1 - 3.4e-13 49.7 0.7 4.3e-13 49.4 0.5 1.2 1 0 0 1 1 1 1 Sel1 repeat EST1_DNA_bind PF10373.4 ESA09486.1 - 0.086 12.0 0.4 0.17 11.0 0.3 1.6 1 1 0 1 1 1 0 Est1 DNA/RNA binding domain TPR_12 PF13424.1 ESA09486.1 - 0.14 12.1 0.3 0.38 10.7 0.2 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA09486.1 - 0.26 10.9 1.7 5.6 6.7 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF945 PF06097.6 ESA09487.1 - 0.14 10.8 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) RGS PF00615.14 ESA09488.1 - 8.1e-16 58.1 0.4 1.1e-15 57.7 0.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF1477 PF07346.6 ESA09489.1 - 0.009 16.0 1.5 0.017 15.1 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1477) EphA2_TM PF14575.1 ESA09489.1 - 0.016 15.6 0.9 0.022 15.1 0.6 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OSTbeta PF15048.1 ESA09489.1 - 0.031 14.3 0.5 0.078 13.0 0.2 1.7 1 1 1 2 2 2 0 Organic solute transporter subunit beta protein 7tm_1 PF00001.16 ESA09489.1 - 0.058 12.5 2.5 0.056 12.5 0.5 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) YjgP_YjgQ PF03739.9 ESA09489.1 - 0.087 11.5 0.2 0.11 11.2 0.2 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family PDEase_I_N PF08499.7 ESA09489.1 - 0.088 12.7 2.8 0.19 11.6 2.0 1.6 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal MFS_2 PF13347.1 ESA09489.1 - 0.096 11.0 1.4 0.13 10.6 1.0 1.2 1 1 0 1 1 1 0 MFS/sugar transport protein Potyvirid-P3 PF13608.1 ESA09489.1 - 0.1 11.7 4.5 0.1 11.6 3.1 1.0 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein PH_10 PF15411.1 ESA09489.1 - 0.13 12.4 4.8 0.14 12.3 3.3 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain TMEM164 PF14808.1 ESA09489.1 - 0.14 11.3 2.2 0.17 11.0 1.5 1.1 1 0 0 1 1 1 0 TMEM164 family FAM176 PF14851.1 ESA09489.1 - 0.38 10.4 5.1 0.31 10.7 1.3 1.9 1 1 1 2 2 2 0 FAM176 family ETRAMP PF09716.5 ESA09489.1 - 0.45 10.4 16.6 4.3 7.3 11.5 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) AgrB PF04647.10 ESA09489.1 - 0.58 9.2 7.4 1.2 8.1 5.0 1.5 1 1 0 1 1 1 0 Accessory gene regulator B DUF843 PF05814.6 ESA09489.1 - 0.64 9.8 7.4 0.55 10.0 3.7 1.8 1 1 1 2 2 2 0 Baculovirus protein of unknown function (DUF843) BLVR PF06375.6 ESA09489.1 - 7.9 6.2 10.6 12 5.7 7.4 1.3 1 0 0 1 1 1 0 Bovine leukaemia virus receptor (BLVR) Cyclin_C PF02984.14 ESA09490.1 - 0.0021 17.9 0.1 0.0037 17.1 0.0 1.5 1 1 1 2 2 2 1 Cyclin, C-terminal domain Abhydrolase_6 PF12697.2 ESA09493.1 - 3.3e-06 27.1 0.0 3.4e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA09493.1 - 1.9e-05 24.3 0.0 1.9e-05 24.3 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.8 ESA09493.1 - 5.8e-05 22.6 0.0 6.9e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 ESA09493.1 - 0.0003 20.5 0.0 0.00033 20.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 ESA09493.1 - 0.012 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_4 PF08386.5 ESA09493.1 - 0.016 15.0 0.0 0.018 14.9 0.0 1.0 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.16 ESA09493.1 - 0.041 13.1 0.0 0.041 13.0 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family Amidohydro_5 PF13594.1 ESA09494.1 - 2.4e-13 49.7 0.1 3.5e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 ESA09494.1 - 2.6e-12 47.0 0.2 3.1e-12 46.7 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 ESA09494.1 - 2.9e-09 37.3 0.2 3.4e-09 37.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 ESA09494.1 - 0.039 13.1 0.8 0.081 12.1 0.6 1.5 1 1 0 1 1 1 0 Amidohydrolase family PepSY PF03413.14 ESA09494.1 - 0.09 13.4 0.0 0.27 11.8 0.0 1.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain TatD_DNase PF01026.16 ESA09494.1 - 0.099 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 TatD related DNase Glyco_hydro_26 PF02156.10 ESA09494.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 SMK-1 PF04802.10 ESA09495.1 - 0.078 12.5 0.2 0.093 12.2 0.1 1.0 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 YmaF PF12788.2 ESA09495.1 - 0.082 13.0 0.2 0.098 12.8 0.1 1.1 1 0 0 1 1 1 0 YmaF family MFS_1 PF07690.11 ESA09497.1 - 0.016 13.9 1.9 0.016 13.9 1.3 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily MFS_1 PF07690.11 ESA09498.1 - 1.3e-39 135.9 18.9 2e-39 135.3 13.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily HMG_box PF00505.14 ESA09499.1 - 4.4e-08 33.2 0.0 6.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09499.1 - 0.015 15.6 0.1 0.023 15.0 0.1 1.2 1 0 0 1 1 1 0 HMG-box domain Kelch_2 PF07646.10 ESA09501.1 - 2.4e-07 30.2 0.1 4.6e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.1 ESA09501.1 - 2.7e-07 30.3 0.6 3e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 ESA09501.1 - 0.00043 19.9 0.3 0.0021 17.8 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA09501.1 - 0.0012 18.3 1.0 0.011 15.2 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.1 ESA09501.1 - 0.0058 16.7 0.4 0.04 14.0 0.0 2.3 2 0 0 2 2 2 1 Kelch motif PRESAN PF09687.5 ESA09502.1 - 0.0014 18.6 6.5 0.0014 18.6 4.5 2.4 2 1 0 2 2 2 1 Plasmodium RESA N-terminal Phage_connect_1 PF05135.8 ESA09502.1 - 0.0021 18.1 3.4 0.081 13.1 0.0 2.5 2 1 0 2 2 2 1 Phage gp6-like head-tail connector protein Luciferase_N PF05295.6 ESA09502.1 - 0.013 15.2 0.7 4 7.3 0.0 3.1 2 2 1 3 3 3 0 Luciferase/LBP N-terminal domain ApoLp-III PF07464.6 ESA09502.1 - 0.033 14.2 2.2 0.077 13.0 0.2 2.2 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) FtsH_ext PF06480.10 ESA09502.1 - 0.11 12.6 0.5 0.2 11.8 0.4 1.4 1 0 0 1 1 1 0 FtsH Extracellular Utp13 PF08625.6 ESA09502.1 - 0.19 11.3 0.7 0.5 10.0 0.2 1.7 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain DUF4179 PF13786.1 ESA09502.1 - 0.58 10.4 9.7 0.096 12.9 0.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4179) SRI PF08236.6 ESA09502.1 - 0.75 9.7 4.3 4.4 7.3 0.5 2.6 2 2 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain TLD PF07534.11 ESA09504.1 - 2.6e-06 27.4 3.8 4.4e-06 26.7 2.6 1.3 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA09504.1 - 5.1e-06 26.2 0.8 2.3e-05 24.1 0.2 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA09504.1 - 3.7e-05 23.6 0.8 0.00021 21.2 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain Sel1 PF08238.7 ESA09505.1 - 1.8e-30 104.6 11.4 1.1e-11 44.9 1.1 4.2 4 0 0 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ESA09505.1 - 0.0091 15.6 11.1 0.56 9.8 1.2 3.8 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.1 ESA09505.1 - 0.015 15.9 3.2 0.24 12.1 0.2 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat Aminotran_5 PF00266.14 ESA09506.1 - 1.5e-94 316.8 0.0 1.8e-94 316.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESA09506.1 - 3.8e-08 32.8 0.0 5.4e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 ESA09506.1 - 7.8e-05 21.8 0.1 0.00012 21.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 ESA09506.1 - 0.026 12.8 0.1 0.039 12.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.14 ESA09506.1 - 0.12 12.2 0.0 8.1 6.3 0.0 2.5 2 0 0 2 2 2 0 B12 binding domain BTB_2 PF02214.17 ESA09507.1 - 0.023 14.9 0.1 0.086 13.0 0.0 2.2 1 1 0 1 1 1 0 BTB/POZ domain Scs3p PF10261.4 ESA09508.1 - 0.26 10.3 1.5 0.26 10.2 1.1 1.1 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF1632 PF07857.7 ESA09510.1 - 0.035 13.3 0.4 0.037 13.2 0.3 1.2 1 0 0 1 1 1 0 CEO family (DUF1632) DUF3328 PF11807.3 ESA09510.1 - 0.087 12.5 0.0 0.094 12.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) FtsL PF04999.8 ESA09510.1 - 0.098 12.3 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Cell division protein FtsL K_trans PF02705.11 ESA09510.1 - 0.16 10.3 1.0 0.2 9.9 0.7 1.2 1 0 0 1 1 1 0 K+ potassium transporter SID-1_RNA_chan PF13965.1 ESA09510.1 - 0.18 9.9 2.4 0.19 9.8 1.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 p450 PF00067.17 ESA09511.1 - 9.8e-44 149.6 0.0 1.2e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kelch_5 PF13854.1 ESA09512.1 - 2.1e-23 81.8 5.0 0.00016 21.5 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 ESA09512.1 - 7e-19 67.3 14.5 0.00042 20.0 0.4 6.9 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA09512.1 - 9.2e-16 57.5 11.8 0.002 18.2 0.0 6.8 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09512.1 - 3.9e-13 48.9 12.5 0.0061 16.6 0.1 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESA09512.1 - 5.3e-12 45.0 14.4 0.014 14.8 0.1 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA09512.1 - 3.9e-10 39.0 0.5 0.0037 16.9 0.0 5.5 5 0 0 5 5 5 3 Kelch motif 7TM_GPCR_Str PF10326.4 ESA09512.1 - 0.0027 16.8 0.0 0.0048 16.0 0.0 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Str HMG_box PF00505.14 ESA09513.1 - 6.5e-09 35.9 0.2 1e-08 35.3 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09513.1 - 3.9e-05 23.9 0.1 5.6e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 HMG-box domain Aldedh PF00171.17 ESA09519.1 - 1.5e-122 409.2 0.2 1.7e-122 409.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 ESA09519.1 - 0.0037 16.0 0.0 0.0049 15.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) ExoD PF06055.7 ESA09521.1 - 0.93 8.5 6.8 0.23 10.5 0.3 2.3 2 0 0 2 2 2 0 Exopolysaccharide synthesis, ExoD TTL PF03133.10 ESA09522.1 - 5.4e-15 55.0 0.0 6.1e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 ESA09522.1 - 0.00067 18.5 0.0 0.00086 18.1 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp UPF0300 PF08594.5 ESA09523.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0300) ubiquitin PF00240.18 ESA09524.1 - 1.9e-14 52.8 0.1 4.8e-14 51.4 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA09524.1 - 0.0024 17.5 0.0 0.0062 16.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ESA09524.1 - 0.0063 15.9 0.4 0.011 15.1 0.0 1.5 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Slp PF03843.8 ESA09524.1 - 0.054 12.4 0.1 0.093 11.7 0.1 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family LRR_6 PF13516.1 ESA09525.1 - 4.7 7.5 7.6 20 5.6 0.7 4.8 4 1 1 5 5 5 0 Leucine Rich repeat HNOBA PF07701.9 ESA09526.1 - 0.02 14.1 0.0 0.02 14.1 0.0 1.1 1 0 0 1 1 1 0 Heme NO binding associated DUF3189 PF11385.3 ESA09526.1 - 0.021 14.4 0.1 0.022 14.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) NERD PF08378.6 ESA09526.1 - 0.1 12.8 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Nuclease-related domain adh_short PF00106.20 ESA09527.1 - 7.7e-17 61.6 0.1 8.5e-17 61.5 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA09527.1 - 2.2e-08 34.2 0.1 2.5e-08 33.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA09527.1 - 3.5e-08 33.3 0.1 4.1e-08 33.0 0.0 1.0 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 ESA09527.1 - 0.033 13.9 0.3 0.098 12.4 0.2 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DFP PF04127.10 ESA09527.1 - 0.05 13.2 0.2 0.14 11.7 0.2 1.8 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein 3Beta_HSD PF01073.14 ESA09527.1 - 0.051 12.2 0.1 0.071 11.7 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF4521 PF15021.1 ESA09527.1 - 0.057 13.0 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4521) Ribosomal_L18_c PF14204.1 ESA09531.1 - 0.079 13.5 0.9 0.079 13.5 0.6 2.1 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region CBM_20 PF00686.14 ESA09534.1 - 0.0019 17.7 0.1 0.0031 17.0 0.1 1.4 1 1 0 1 1 1 1 Starch binding domain APCDDC PF14921.1 ESA09535.1 - 0.15 11.4 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 Sec23_trunk PF04811.10 ESA09536.1 - 1.1e-76 257.4 0.0 1.9e-76 256.6 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.10 ESA09536.1 - 3.7e-18 64.7 3.6 6.6e-18 63.9 2.5 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Pkinase_Tyr PF07714.12 ESA09537.1 - 5.1e-19 68.3 0.0 3e-15 55.9 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA09537.1 - 3.2e-15 55.9 2.9 9.1e-14 51.2 1.1 2.3 2 0 0 2 2 2 2 Protein kinase domain DUF4150 PF13665.1 ESA09539.1 - 0.046 13.6 0.1 0.091 12.6 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4150) ATP-synt_ab PF00006.20 ESA09539.1 - 0.05 13.0 0.0 0.053 13.0 0.0 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF2353 PF09789.4 ESA09540.1 - 0.0051 16.1 24.1 0.02 14.1 16.7 1.8 1 1 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Laminin_B PF00052.13 ESA09540.1 - 0.018 14.6 2.6 0.025 14.1 1.8 1.2 1 0 0 1 1 1 0 Laminin B (Domain IV) DUF3884 PF13024.1 ESA09540.1 - 0.066 12.6 0.4 0.86 9.0 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3884) PTB PF08416.8 ESA09540.1 - 0.13 12.2 2.5 0.73 9.7 0.2 2.6 2 1 1 3 3 3 0 Phosphotyrosine-binding domain AAA_32 PF13654.1 ESA09540.1 - 0.13 10.8 14.4 0.15 10.6 10.0 1.1 1 0 0 1 1 1 0 AAA domain CALCOCO1 PF07888.6 ESA09540.1 - 0.34 9.1 25.0 0.46 8.7 17.3 1.3 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.3 ESA09540.1 - 0.44 10.4 25.5 0.87 9.4 6.8 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.1 ESA09540.1 - 0.51 9.4 29.8 0.19 10.9 2.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2968 PF11180.3 ESA09540.1 - 0.91 8.8 20.5 2.6 7.3 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF3113 PF11310.3 ESA09540.1 - 1.3 8.8 5.0 9.2 6.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) DUF4201 PF13870.1 ESA09540.1 - 1.5 8.2 28.2 36 3.7 19.5 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF948 PF06103.6 ESA09540.1 - 2.4 8.0 8.4 0.93 9.4 1.3 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) KaiC PF06745.8 ESA09540.1 - 2.6 7.0 8.3 0.74 8.8 2.4 1.9 1 1 1 2 2 2 0 KaiC Tropomyosin_1 PF12718.2 ESA09540.1 - 2.8 7.7 31.8 4e+02 0.7 22.0 2.3 1 1 0 1 1 1 0 Tropomyosin like Reo_sigmaC PF04582.7 ESA09540.1 - 3 6.9 7.9 1.4 8.0 0.6 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TBPIP PF07106.8 ESA09540.1 - 3.4 7.1 27.6 1.2 8.7 5.5 2.5 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CENP-H PF05837.7 ESA09540.1 - 5.9 7.1 25.3 5.3 7.2 7.7 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) BRE1 PF08647.6 ESA09540.1 - 8.7 6.3 30.0 0.5 10.3 10.0 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase APG6 PF04111.7 ESA09540.1 - 9.4 5.1 28.9 2 7.4 6.0 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Pkinase_Tyr PF07714.12 ESA09543.1 - 4.8e-26 91.3 0.0 6.2e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09543.1 - 2.1e-22 79.5 0.0 3e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HSP70 PF00012.15 ESA09544.1 - 0.0003 18.8 5.9 0.00033 18.7 4.1 1.0 1 0 0 1 1 1 1 Hsp70 protein Bac_GDH PF05088.7 ESA09544.1 - 0.038 11.3 1.3 0.043 11.2 0.9 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DUF2015 PF09435.5 ESA09544.1 - 0.041 13.6 0.1 0.042 13.6 0.1 1.1 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) TBPIP PF07106.8 ESA09544.1 - 0.21 11.1 7.0 0.24 10.9 4.9 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PRP1_N PF06424.7 ESA09544.1 - 0.3 11.3 2.5 0.28 11.4 1.1 1.5 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF3513 PF12026.3 ESA09544.1 - 0.46 10.0 2.9 0.52 9.8 2.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) KID PF02524.9 ESA09544.1 - 0.59 10.4 2.5 1.4 9.3 0.8 2.5 2 0 0 2 2 2 0 KID repeat FlxA PF14282.1 ESA09544.1 - 6.1 6.8 9.6 0.52 10.2 2.6 1.9 1 1 1 2 2 2 0 FlxA-like protein Kelch_6 PF13964.1 ESA09547.1 - 0.046 13.9 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Calici_MSP PF05752.6 ESA09548.1 - 0.099 12.2 0.6 0.13 11.8 0.4 1.1 1 0 0 1 1 1 0 Calicivirus minor structural protein Syntaphilin PF15290.1 ESA09549.1 - 0.11 11.9 1.8 0.19 11.1 0.0 2.0 2 0 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp SAM_1 PF00536.25 ESA09550.1 - 5e-05 23.3 0.0 9.6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FUR PF01475.14 ESA09550.1 - 0.0044 16.9 0.2 0.3 11.0 0.0 2.5 2 0 0 2 2 2 1 Ferric uptake regulator family Stap_Strp_tox_C PF02876.12 ESA09550.1 - 0.069 13.3 0.9 0.59 10.3 0.2 2.2 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Nipped-B_C PF12830.2 ESA09554.1 - 6.7e-53 179.1 0.2 1.1e-52 178.4 0.2 1.3 1 0 0 1 1 1 1 Sister chromatid cohesion C-terminus E1_DerP2_DerF2 PF02221.10 ESA09555.1 - 5.7e-08 33.0 0.1 7.3e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 ML domain DUF659 PF04937.10 ESA09556.1 - 2.3e-06 27.1 0.4 2.5e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) MNE1 PF13762.1 ESA09556.1 - 0.14 12.2 3.9 0.16 11.9 2.7 1.1 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Nckap1 PF09735.4 ESA09556.1 - 0.22 8.9 2.4 0.21 9.0 1.7 1.0 1 0 0 1 1 1 0 Membrane-associated apoptosis protein Pkinase PF00069.20 ESA09558.1 - 7.4e-23 81.0 1.6 8.8e-22 77.4 1.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09558.1 - 7.8e-17 61.2 0.0 9.2e-17 60.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2608 PF11019.3 ESA09558.1 - 0.0061 15.5 0.2 0.0089 15.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2608) EcoEI_R_C PF08463.5 ESA09558.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 EcoEI R protein C-terminal APH PF01636.18 ESA09558.1 - 0.064 12.9 0.2 0.091 12.4 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family MIR PF02815.14 ESA09559.1 - 0.0095 15.4 0.0 0.032 13.7 0.0 1.8 1 1 0 1 1 1 1 MIR domain RNA_pol_Rpb4 PF03874.11 ESA09559.1 - 0.16 11.9 2.1 0.31 11.0 1.4 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb4 Pkinase_Tyr PF07714.12 ESA09560.1 - 8.5e-07 28.2 0.3 1.3e-06 27.6 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09560.1 - 0.032 13.3 0.5 0.065 12.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain RRP7 PF12923.2 ESA09560.1 - 0.12 12.4 2.2 0.17 11.9 1.5 1.3 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) DUF4435 PF14491.1 ESA09561.1 - 0.027 14.3 1.4 0.029 14.2 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4435) Pkinase_Tyr PF07714.12 ESA09562.1 - 0.034 13.2 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA09563.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Dimer_Tnp_hAT PF05699.9 ESA09565.1 - 1.2e-09 37.6 0.1 1.3e-09 37.5 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Complex1_LYR PF05347.10 ESA09566.1 - 1.3e-05 24.9 0.7 1.3e-05 24.9 0.5 1.6 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA09566.1 - 0.0034 17.5 4.2 0.0071 16.5 2.9 1.7 1 1 0 1 1 1 1 Complex1_LYR-like YlbD_coat PF14071.1 ESA09566.1 - 0.0069 16.4 0.4 0.008 16.2 0.3 1.2 1 0 0 1 1 1 1 Putative coat protein Ribosomal_S17e PF00833.13 ESA09566.1 - 0.025 14.3 1.4 0.04 13.6 0.8 1.5 1 1 1 2 2 2 0 Ribosomal S17 DUF3318 PF11780.3 ESA09566.1 - 0.14 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Sad1_UNC PF07738.8 ESA09567.1 - 9.8e-31 106.3 0.1 1.9e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Reo_sigmaC PF04582.7 ESA09567.1 - 0.25 10.4 3.1 4.3 6.4 0.2 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Kinetocho_Slk19 PF12709.2 ESA09567.1 - 0.9 9.6 7.9 0.31 11.1 0.3 3.3 2 1 1 3 3 3 0 Central kinetochore-associated GATase PF00117.23 ESA09569.1 - 2.2e-16 59.8 0.0 3e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Cactin_mid PF10312.4 ESA09570.1 - 2.2e-66 222.7 13.6 5.6e-66 221.4 9.4 1.7 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.4 ESA09570.1 - 1.3e-59 199.2 8.5 2.2e-59 198.4 5.9 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein YolD PF08863.5 ESA09570.1 - 0.013 15.3 1.1 0.065 13.0 0.6 2.4 1 1 0 1 1 1 0 YolD-like protein PI3_PI4_kinase PF00454.22 ESA09571.1 - 9.8e-66 221.5 0.4 1.2e-65 221.3 0.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 ESA09571.1 - 3.5e-13 48.7 0.4 5.7e-13 48.0 0.3 1.4 1 0 0 1 1 1 1 FATC domain DUF313 PF03754.8 ESA09572.1 - 0.25 11.2 1.0 0.47 10.3 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF313) SHMT PF00464.14 ESA09573.1 - 9.6e-204 676.2 0.0 1.1e-203 675.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Lipase_GDSL PF00657.17 ESA09575.1 - 1.1e-10 41.8 0.0 1.2e-10 41.5 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 ESA09575.1 - 0.063 13.4 0.0 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family COX14 PF14880.1 ESA09576.1 - 0.049 13.2 0.1 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c assembly MARVEL PF01284.18 ESA09577.1 - 0.0044 16.8 0.0 0.007 16.1 0.0 1.5 1 1 0 1 1 1 1 Membrane-associating domain TRAP_alpha PF03896.11 ESA09577.1 - 0.016 14.1 2.6 0.027 13.4 1.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.17 ESA09577.1 - 0.018 14.0 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TEX19 PF15553.1 ESA09577.1 - 0.36 10.6 6.5 1.3 8.9 4.5 1.7 1 1 0 1 1 1 0 Testis-expressed protein 19 DUF106 PF01956.11 ESA09577.1 - 0.42 10.1 6.5 0.15 11.5 1.9 2.0 1 1 1 2 2 2 0 Integral membrane protein DUF106 Astro_capsid PF03115.9 ESA09577.1 - 0.42 8.7 1.8 0.51 8.5 1.2 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Bap31 PF05529.7 ESA09577.1 - 1.1 8.6 4.8 2 7.8 3.3 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Sel1 PF08238.7 ESA09579.1 - 4.3e-90 294.1 36.7 4.8e-13 49.2 0.1 9.0 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA09579.1 - 6.5e-11 41.9 19.2 0.3 11.6 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA09579.1 - 2.2e-09 36.7 21.3 0.18 12.0 0.0 8.9 7 3 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA09579.1 - 5.5e-08 32.3 41.6 0.012 15.2 5.0 7.2 1 1 4 6 6 6 4 TPR repeat MIT PF04212.13 ESA09579.1 - 1.8e-07 30.9 24.1 1.9 8.4 0.2 7.4 7 1 0 7 7 7 4 MIT (microtubule interacting and transport) domain Peptidase_C14 PF00656.17 ESA09579.1 - 6.9e-06 25.9 0.0 1.3 8.6 0.0 3.8 1 1 2 3 3 3 2 Caspase domain TPR_20 PF14561.1 ESA09579.1 - 0.00069 19.6 0.5 22 5.2 0.0 4.7 2 2 4 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA09579.1 - 0.002 18.7 5.7 5.3 7.8 0.1 5.1 3 1 3 6 6 6 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA09579.1 - 0.0048 16.6 1.5 42 3.9 0.0 5.6 7 0 0 7 7 7 0 Lung surfactant protein D coiled-coil trimerisation TPR_12 PF13424.1 ESA09579.1 - 0.018 14.9 21.7 0.16 11.9 1.8 6.5 2 2 5 7 7 7 0 Tetratricopeptide repeat DUF3674 PF12426.3 ESA09579.1 - 0.025 13.9 7.4 1.6 8.2 0.1 3.7 4 0 0 4 4 4 0 RNA dependent RNA polymerase DUF1389 PF07146.6 ESA09579.1 - 0.034 13.1 5.4 0.91 8.5 0.0 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1389) TPR_19 PF14559.1 ESA09579.1 - 0.11 12.8 8.5 11 6.4 0.4 5.9 6 1 1 7 7 7 0 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA09579.1 - 0.14 12.1 0.0 2.9 8.0 0.0 3.1 2 2 2 4 4 4 0 Influenza Matrix protein (M1) C-terminal domain Nro1 PF12753.2 ESA09579.1 - 0.53 9.1 11.1 1.2 8.0 0.3 4.1 2 2 2 4 4 4 0 Nuclear pore complex subunit Nro1 GDYXXLXY PF14345.1 ESA09579.1 - 6.9 6.5 6.6 18 5.1 0.3 2.9 2 1 1 3 3 3 0 GDYXXLXY protein IstB_IS21 PF01695.12 ESA09580.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.11 ESA09580.1 - 0.024 13.8 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_17 PF13207.1 ESA09580.1 - 0.031 15.0 0.0 0.079 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 ESA09580.1 - 0.032 13.8 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESA09580.1 - 0.048 13.4 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain AAA_16 PF13191.1 ESA09580.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain TFIIF_beta PF02270.10 ESA09584.1 - 1.7e-53 182.2 0.6 1.1e-36 127.0 0.1 2.0 1 1 1 2 2 2 2 Transcription initiation factor IIF, beta subunit Borrelia_orfA PF02414.10 ESA09584.1 - 0.1 11.6 0.1 0.1 11.6 0.1 1.8 2 0 0 2 2 2 0 Borrelia ORF-A Ribophorin_I PF04597.9 ESA09585.1 - 1.9e-130 435.2 13.4 2.2e-130 435.0 9.3 1.0 1 0 0 1 1 1 1 Ribophorin I DUF912 PF06024.7 ESA09586.1 - 0.061 13.3 5.8 0.096 12.7 4.0 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) PBP1_TM PF14812.1 ESA09586.1 - 0.29 11.4 3.2 0.42 10.9 2.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.4 ESA09586.1 - 0.54 8.9 9.5 0.56 8.8 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF506 PF04720.7 ESA09586.1 - 2.3 7.7 4.7 3 7.4 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) DUF1882 PF08966.6 ESA09587.1 - 0.024 14.5 0.4 0.06 13.3 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) YtxC PF08812.6 ESA09587.1 - 0.054 12.9 1.0 0.063 12.7 0.7 1.1 1 0 0 1 1 1 0 YtxC-like family HHH_5 PF14520.1 ESA09587.1 - 0.14 12.3 0.1 1.4 9.1 0.1 2.1 1 1 0 1 1 1 0 Helix-hairpin-helix domain Oxidored_q1_N PF00662.15 ESA09588.1 - 0.95 9.0 7.4 1.5 8.4 2.4 2.3 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus MtrE PF04206.7 ESA09589.1 - 0.088 11.8 0.8 0.11 11.4 0.6 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E AAA_22 PF13401.1 ESA09590.1 - 0.00015 21.9 0.0 0.00042 20.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 ESA09590.1 - 0.01 14.9 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.1 ESA09590.1 - 0.014 15.3 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 ESA09590.1 - 0.027 14.1 0.0 0.98 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 ESA09590.1 - 0.032 13.1 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 ESA09590.1 - 0.081 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESA09590.1 - 0.094 12.9 0.1 0.19 11.8 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Conotoxin PF02950.12 ESA09591.1 - 1.2 10.0 5.5 1.7 9.4 3.8 1.4 1 1 0 1 1 1 0 Conotoxin O-FucT PF10250.4 ESA09593.1 - 7.8e-08 31.8 0.9 3.8e-06 26.2 0.6 2.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase HHH PF00633.18 ESA09594.1 - 0.00079 18.9 0.0 0.003 17.1 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif Aldo_ket_red PF00248.16 ESA09596.1 - 6.8e-82 274.4 0.0 7.7e-82 274.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Serinc PF03348.10 ESA09597.1 - 2.7e-147 490.9 5.3 3.1e-147 490.7 3.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Tetraspannin PF00335.15 ESA09597.1 - 0.0036 16.6 7.9 0.0036 16.6 5.5 3.0 2 1 1 3 3 3 1 Tetraspanin family Polysacc_synt_3 PF13440.1 ESA09597.1 - 0.011 15.1 14.4 0.029 13.8 0.8 2.8 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein DUF3328 PF11807.3 ESA09597.1 - 0.041 13.5 3.0 4.6 6.8 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF3328) DUF2231 PF09990.4 ESA09597.1 - 2.3 8.6 10.5 1 9.7 0.2 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) MscS_TM PF12794.2 ESA09597.1 - 6.1 5.3 14.9 0.47 9.0 6.4 2.1 2 1 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 zf-CCHC_2 PF13696.1 ESA09598.1 - 1.1e-11 44.0 21.4 3.2e-05 23.3 1.0 3.7 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.18 ESA09598.1 - 4.6e-07 29.4 24.9 0.00016 21.4 0.3 4.5 4 1 0 4 4 4 2 Zinc knuckle CwfJ_C_1 PF04677.10 ESA09598.1 - 0.075 12.6 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 zinc-ribbons_6 PF07191.7 ESA09598.1 - 0.49 10.2 9.4 0.28 11.0 1.5 2.5 1 1 1 2 2 2 0 zinc-ribbons OrfB_Zn_ribbon PF07282.6 ESA09598.1 - 1.6 8.4 10.3 0.39 10.3 3.2 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-CCHC_4 PF14392.1 ESA09598.1 - 2.1 8.0 11.7 4.5 7.0 1.2 2.7 2 0 0 2 2 2 0 Zinc knuckle PHD PF00628.24 ESA09598.1 - 3.9 7.2 18.9 1.4 8.6 5.0 2.8 2 1 0 2 2 2 0 PHD-finger MFS_1 PF07690.11 ESA09602.1 - 7.8e-38 130.0 27.7 1e-36 126.4 5.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA09602.1 - 2.7e-08 32.8 10.7 4.4e-07 28.8 0.6 3.5 3 0 0 3 3 3 3 Sugar (and other) transporter MFS_3 PF05977.8 ESA09602.1 - 0.0075 14.4 0.1 0.013 13.6 0.1 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector DUF3099 PF11298.3 ESA09602.1 - 5.7 6.7 11.6 0.79 9.5 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3099) DUF2222 PF09984.4 ESA09603.1 - 0.0001 21.7 1.3 0.079 12.3 0.1 2.1 1 1 1 2 2 2 2 Uncharacterized signal transduction histidine kinase domain (DUF2222) Ribonuc_2-5A PF06479.7 ESA09603.1 - 0.015 15.1 2.5 0.047 13.5 1.7 1.9 1 1 0 1 1 1 0 Ribonuclease 2-5A CAT PF00302.13 ESA09603.1 - 0.027 14.0 0.3 0.033 13.8 0.2 1.3 1 1 0 1 1 1 0 Chloramphenicol acetyltransferase Nup188 PF10487.4 ESA09603.1 - 0.11 10.4 7.8 0.11 10.3 5.4 1.0 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 DUF445 PF04286.7 ESA09603.1 - 0.15 11.5 2.7 0.19 11.1 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) LAGLIDADG_WhiA PF14527.1 ESA09603.1 - 0.16 11.8 1.8 0.23 11.3 0.3 1.9 1 1 1 2 2 2 0 WhiA LAGLIDADG-like domain AAA_23 PF13476.1 ESA09603.1 - 0.17 12.2 5.0 0.2 11.9 3.5 1.0 1 0 0 1 1 1 0 AAA domain DUF758 PF05527.6 ESA09603.1 - 0.31 10.6 6.0 0.2 11.2 1.1 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF758) SapB_1 PF05184.10 ESA09603.1 - 0.6 10.0 4.6 3.1 7.7 0.3 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF4441 PF14536.1 ESA09603.1 - 2.9 7.9 9.9 1.1 9.2 4.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4441) RICH PF05062.7 ESA09603.1 - 9.2 6.4 8.6 2.4 8.3 0.9 2.3 1 1 1 2 2 2 0 RICH domain Phage_lysozyme PF00959.14 ESA09605.1 - 1e-15 57.9 0.0 1.3e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme DUF3684 PF12449.3 ESA09607.1 - 1.5e-159 532.8 0.1 2.3e-158 528.8 0.1 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) DUF3684 PF12449.3 ESA09608.1 - 2.4e-163 545.3 8.6 1.2e-129 433.8 1.2 2.0 1 1 0 2 2 2 2 Protein of unknown function (DUF3684) SpoIIID PF12116.3 ESA09608.1 - 0.0012 18.7 0.1 0.39 10.6 0.0 3.4 3 0 0 3 3 3 1 Stage III sporulation protein D DUF261 PF03196.8 ESA09608.1 - 0.035 14.0 6.9 1.1 9.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function, DUF261 DUF3024 PF11225.3 ESA09608.1 - 0.068 13.0 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) RNA_pol_Rpb4 PF03874.11 ESA09608.1 - 1.6 8.7 5.7 6.6 6.7 0.3 3.3 3 0 0 3 3 3 0 RNA polymerase Rpb4 PMSR PF01625.16 ESA09609.1 - 0.041 13.7 0.2 0.041 13.7 0.1 1.9 2 0 0 2 2 2 0 Peptide methionine sulfoxide reductase DUF3201 PF11447.3 ESA09610.1 - 0.14 11.5 0.9 0.16 11.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) DUF3420 PF11900.3 ESA09613.1 - 0.44 10.6 6.1 0.97 9.5 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3420) Pkinase PF00069.20 ESA09614.1 - 8.9e-09 34.8 0.1 4.3e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09614.1 - 6.7e-07 28.6 0.0 0.0062 15.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase RNase_P_pop3 PF08228.6 ESA09614.1 - 0.029 14.2 0.1 0.038 13.8 0.1 1.2 1 0 0 1 1 1 0 RNase P subunit Pop3 Rrf2 PF02082.15 ESA09615.1 - 0.0015 18.5 0.1 0.26 11.4 0.0 2.5 2 0 0 2 2 2 1 Transcriptional regulator NOB1_Zn_bind PF08772.6 ESA09615.1 - 0.057 13.2 14.6 0.65 9.8 0.2 3.5 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Spt5-NGN PF03439.8 ESA09615.1 - 0.2 11.4 2.6 21 4.9 0.0 3.5 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section BCMA-Tall_bind PF09257.5 ESA09615.1 - 2.3 8.2 6.4 11 6.0 0.2 3.3 3 0 0 3 3 3 0 BCMA, TALL-1 binding MAP65_ASE1 PF03999.7 ESA09616.1 - 1.8e-09 36.7 12.5 1.8e-09 36.7 8.6 2.4 1 1 1 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) DUF2235 PF09994.4 ESA09619.1 - 0.0003 20.2 0.0 0.00032 20.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Gemini_AL1 PF00799.15 ESA09620.1 - 1.1e-07 31.6 0.0 1.4e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Geminivirus Rep catalytic domain WD40 PF00400.27 ESA09624.1 - 0.00048 19.8 0.0 0.57 10.1 0.0 2.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Apc4_WD40 PF12894.2 ESA09624.1 - 0.1 12.1 0.0 0.53 9.8 0.0 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain CLAMP PF14769.1 ESA09625.1 - 0.09 12.9 0.3 0.36 11.0 0.1 1.9 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 DUF2404 PF10296.4 ESA09626.1 - 3.8e-11 42.9 0.0 1.1e-10 41.5 0.0 1.8 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) HLH PF00010.21 ESA09627.1 - 1.5e-12 47.0 0.4 2.3e-12 46.4 0.3 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AAA_27 PF13514.1 ESA09627.1 - 0.039 11.6 2.7 0.045 11.4 1.8 1.0 1 0 0 1 1 1 0 AAA domain RcbX PF02341.10 ESA09627.1 - 0.093 12.8 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 RbcX protein Spc7 PF08317.6 ESA09627.1 - 0.19 10.3 3.7 0.22 10.1 2.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2404 PF10296.4 ESA09628.1 - 1.2e-07 31.7 0.5 8.5e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) Pkinase_Tyr PF07714.12 ESA09629.1 - 3.3e-19 68.9 0.0 1.3e-18 66.9 0.0 2.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09629.1 - 1e-18 67.4 1.5 1e-18 67.4 1.0 2.4 2 0 0 2 2 2 1 Protein kinase domain TFIIA_gamma_N PF02268.11 ESA09629.1 - 7.1e-08 31.9 8.9 0.35 10.4 0.0 7.5 7 0 0 7 7 7 2 Transcription initiation factor IIA, gamma subunit, helical domain APH PF01636.18 ESA09629.1 - 0.87 9.2 0.2 1.4 8.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family CENP-F_leu_zip PF10473.4 ESA09629.1 - 1 9.2 14.8 33 4.3 0.1 6.8 8 0 0 8 8 8 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pkinase PF00069.20 ESA09631.1 - 7.4e-28 97.3 0.0 8.2e-28 97.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09631.1 - 2e-25 89.3 0.0 2.2e-25 89.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA09631.1 - 0.0054 16.4 1.0 0.008 15.9 0.3 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family PsbU PF06514.6 ESA09631.1 - 0.04 13.7 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pkinase_Tyr PF07714.12 ESA09632.1 - 2.4e-12 46.4 0.3 4.9e-12 45.4 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09632.1 - 4.2e-09 35.9 0.5 1.2e-08 34.4 0.4 1.8 1 0 0 1 1 1 1 Protein kinase domain Yopt PF09467.5 ESA09632.1 - 0.068 13.0 0.0 0.72 9.7 0.0 2.3 2 0 0 2 2 2 0 Hypothetical protein Yopt Sigma54_activ_2 PF14532.1 ESA09633.1 - 0.024 14.6 0.1 0.099 12.6 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Sel1 PF08238.7 ESA09634.1 - 6.6e-26 90.1 5.3 2e-05 25.0 0.1 4.0 4 0 0 4 4 4 4 Sel1 repeat F-box-like PF12937.2 ESA09635.1 - 2.5e-05 23.9 1.0 7.4e-05 22.3 0.7 1.8 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.20 ESA09636.1 - 1e-20 73.9 6.7 1.7e-20 73.2 4.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09636.1 - 1.9e-13 50.1 1.9 2.7e-13 49.5 1.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA09636.1 - 0.00011 21.2 1.4 0.00013 21.1 0.2 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA09636.1 - 0.0042 16.0 0.0 0.0097 14.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA09636.1 - 0.044 13.1 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL LsmAD PF06741.8 ESA09637.1 - 0.018 15.1 1.0 0.025 14.6 0.7 1.2 1 0 0 1 1 1 0 LsmAD domain EssA PF10661.4 ESA09637.1 - 0.19 11.3 1.7 0.22 11.2 1.2 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA BBS2_Mid PF14783.1 ESA09638.1 - 6.5e-06 25.8 0.1 0.4 10.4 0.0 4.1 3 2 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.1 ESA09638.1 - 0.00041 20.6 0.0 0.0015 18.8 0.0 2.0 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESA09638.1 - 0.015 14.9 0.0 4.9 6.9 0.0 2.4 2 0 0 2 2 2 0 FG-GAP repeat zf-BED PF02892.10 ESA09642.1 - 6.6e-08 32.1 3.2 1.1e-07 31.4 2.2 1.4 1 0 0 1 1 1 1 BED zinc finger zf-TRAF PF02176.13 ESA09642.1 - 0.29 11.5 3.7 1.2 9.5 1.5 2.1 1 1 1 2 2 2 0 TRAF-type zinc finger RTC4 PF14474.1 ESA09644.1 - 2e-15 56.7 0.0 2.3e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 RTC4-like domain HECT PF00632.20 ESA09645.1 - 4.6e-07 29.3 4.9 1.1e-06 28.1 3.4 1.7 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) gag_pre-integrs PF13976.1 ESA09645.1 - 0.014 15.0 0.0 0.055 13.1 0.0 2.0 1 0 0 1 1 1 0 GAG-pre-integrase domain Sel1 PF08238.7 ESA09646.1 - 4.2e-33 113.0 18.4 3.8e-11 43.2 2.2 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ESA09646.1 - 0.0029 17.9 5.9 0.92 10.1 0.7 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA09646.1 - 0.0046 16.5 9.9 0.0075 15.8 0.6 2.7 2 1 0 2 2 2 1 TPR repeat TPR_16 PF13432.1 ESA09646.1 - 0.0062 17.1 0.9 0.59 10.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA09646.1 - 0.013 15.2 0.7 17 5.5 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat PPR PF01535.15 ESA09646.1 - 0.091 12.7 0.9 4 7.6 0.1 2.8 3 0 0 3 3 3 0 PPR repeat TPR_19 PF14559.1 ESA09646.1 - 0.15 12.4 0.5 0.15 12.4 0.3 2.5 3 1 1 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA09646.1 - 0.18 11.6 7.7 3.2 7.6 0.8 3.0 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESA09646.1 - 0.85 9.3 23.1 1.3 8.7 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat LRR_6 PF13516.1 ESA09647.1 - 2.5e-10 39.3 6.1 0.0022 17.8 0.0 5.4 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 ESA09647.1 - 1.5e-07 30.8 2.2 0.061 12.9 0.0 4.2 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA09647.1 - 1.3e-06 28.0 5.3 0.00013 21.6 0.2 3.7 1 1 2 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 ESA09647.1 - 1.2e-05 24.6 7.1 0.75 10.0 0.5 5.4 5 1 1 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA09647.1 - 0.0014 18.4 4.2 14 6.4 0.0 5.5 6 1 1 7 7 7 1 Leucine rich repeat DUF3557 PF12078.3 ESA09647.1 - 0.049 13.3 0.3 0.2 11.3 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3557) Hep_core_N PF08290.6 ESA09647.1 - 6 6.3 0.0 6 6.3 0.0 2.9 3 0 0 3 3 3 0 Hepatitis core protein, putative zinc finger DDE_1 PF03184.14 ESA09650.1 - 5.1e-07 29.0 0.5 8.6e-07 28.3 0.3 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HlyD_2 PF12700.2 ESA09650.1 - 0.024 13.8 3.3 0.031 13.4 2.3 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF4180 PF13788.1 ESA09650.1 - 0.048 13.3 0.0 0.12 12.0 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4180) SASP_gamma PF04259.9 ESA09650.1 - 0.36 11.0 8.9 0.12 12.5 3.9 1.8 2 0 0 2 2 2 0 Small, acid-soluble spore protein, gamma-type DUF4240 PF14024.1 ESA09651.1 - 0.073 12.9 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4240) Thymosin PF01290.15 ESA09652.1 - 1.4e-07 30.9 7.4 2.6e-07 30.1 5.1 1.6 1 1 0 1 1 1 1 Thymosin beta-4 family DUF4090 PF13319.1 ESA09652.1 - 0.0078 16.1 0.4 0.0089 15.9 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4090) DUF4200 PF13863.1 ESA09652.1 - 1.9 8.4 10.6 2.1 8.3 7.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Spc7 PF08317.6 ESA09652.1 - 3.3 6.2 8.9 3.5 6.1 6.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF809 PF05663.6 ESA09652.1 - 5.7 6.8 11.8 5.8 6.8 8.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF809) UPF0054 PF02130.12 ESA09653.1 - 1e-15 57.2 0.1 1.3e-15 56.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Vpu PF00558.14 ESA09653.1 - 0.093 12.2 3.4 0.2 11.2 2.3 1.6 1 0 0 1 1 1 0 Vpu protein DUF3810 PF12725.2 ESA09653.1 - 0.14 11.0 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Ribosomal_S6 PF01250.12 ESA09654.1 - 0.006 16.4 1.0 0.038 13.8 0.3 2.3 2 0 0 2 2 2 1 Ribosomal protein S6 NAD_binding_5 PF07994.7 ESA09654.1 - 0.013 15.0 0.4 0.017 14.6 0.3 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase DUF4472 PF14739.1 ESA09654.1 - 0.021 15.3 1.3 0.038 14.4 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) DUF1931 PF09123.6 ESA09654.1 - 0.023 14.6 0.6 0.19 11.6 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1931) ATP-synt_B PF00430.13 ESA09654.1 - 0.049 13.4 0.0 1.2 8.9 0.0 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Ldh_1_C PF02866.13 ESA09654.1 - 0.077 12.7 0.8 0.13 12.0 0.5 1.5 1 1 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Reo_sigmaC PF04582.7 ESA09654.1 - 0.23 10.5 1.3 0.72 8.9 1.0 1.6 1 1 0 1 1 1 0 Reovirus sigma C capsid protein BSP PF04450.7 ESA09655.1 - 0.007 15.8 0.0 0.008 15.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase of plants and bacteria YbaJ PF10757.4 ESA09655.1 - 0.044 13.9 0.8 0.06 13.4 0.5 1.1 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ MIR PF02815.14 ESA09656.1 - 0.018 14.6 0.0 0.16 11.4 0.0 2.2 1 1 1 2 2 2 0 MIR domain DUF2451 PF10474.4 ESA09656.1 - 0.069 12.8 0.2 0.4 10.3 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) V_ATPase_I PF01496.14 ESA09657.1 - 0.053 11.3 2.3 0.083 10.7 1.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4389 PF14333.1 ESA09657.1 - 0.16 11.6 4.6 2.3 7.9 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4389) DUF1761 PF08570.5 ESA09657.1 - 3.9 7.4 11.8 0.2 11.6 1.6 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1761) MARVEL PF01284.18 ESA09659.1 - 1.1e-07 31.7 12.7 1.9e-07 30.9 8.8 1.4 1 0 0 1 1 1 1 Membrane-associating domain DUF588 PF04535.7 ESA09659.1 - 5.6e-06 26.0 3.6 1.2e-05 24.9 2.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF588) COX7C PF02935.11 ESA09659.1 - 0.027 14.2 0.1 0.027 14.2 0.1 1.9 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIIc NfeD PF01957.13 ESA09659.1 - 2.2 8.4 6.0 1.6 8.8 1.8 2.0 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding DUF308 PF03729.8 ESA09659.1 - 2.5 8.1 9.0 0.11 12.5 1.9 1.9 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Collagen PF01391.13 ESA09660.1 - 0.0044 16.5 1.0 0.0065 15.9 0.7 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DUF1940 PF09155.5 ESA09661.1 - 0.053 13.3 0.4 2.7 7.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1940) DUF960 PF06124.6 ESA09661.1 - 0.062 13.5 0.7 0.18 12.1 0.5 1.8 1 0 0 1 1 1 0 Staphylococcal protein of unknown function (DUF960) TatD_DNase PF01026.16 ESA09663.1 - 3.8e-48 163.9 0.0 5e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.9 ESA09663.1 - 0.0074 15.8 0.0 0.27 10.7 0.0 2.9 1 1 0 2 2 2 1 Amidohydrolase Sld5 PF05916.6 ESA09664.1 - 5.8e-14 52.2 1.0 8.9e-14 51.7 0.7 1.3 1 0 0 1 1 1 1 GINS complex protein SBDS PF01172.13 ESA09665.1 - 5.2e-20 71.0 0.1 8e-20 70.4 0.1 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF1910 PF08928.5 ESA09667.1 - 0.029 14.3 0.2 0.041 13.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) DUF1819 PF08849.6 ESA09667.1 - 0.075 12.4 0.4 1.9 7.8 0.1 2.0 2 0 0 2 2 2 0 Putative inner membrane protein (DUF1819) Herpes_gE PF02480.11 ESA09668.1 - 0.092 10.9 0.0 0.19 9.9 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PLAC8 PF04749.12 ESA09669.1 - 2e-25 89.3 28.7 2.4e-25 89.1 19.9 1.1 1 0 0 1 1 1 1 PLAC8 family WD40 PF00400.27 ESA09670.1 - 7.7e-52 171.4 12.1 2e-11 43.2 0.1 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 ESA09670.1 - 3.3e-06 26.1 0.2 0.077 11.7 0.0 3.9 1 1 2 4 4 4 2 Nup133 N terminal like Nup160 PF11715.3 ESA09670.1 - 3.9e-05 21.9 4.3 1.1 7.2 0.1 4.8 3 1 1 4 4 4 3 Nucleoporin Nup120/160 DUF3312 PF11768.3 ESA09670.1 - 4.9e-05 21.7 0.0 7.8e-05 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3312) Glyco_hydro_47 PF01532.15 ESA09671.1 - 9.7e-136 453.0 0.6 1.1e-135 452.8 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 LANC_like PF05147.8 ESA09671.1 - 0.017 13.7 0.1 1.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Lanthionine synthetase C-like protein PTN_MK_N PF05196.8 ESA09673.1 - 0.12 12.3 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 PTN/MK heparin-binding protein family, N-terminal domain Protein_K PF12283.3 ESA09674.1 - 0.076 12.9 0.1 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage protein K Sterile PF03015.14 ESA09674.1 - 0.92 9.8 3.9 0.88 9.8 0.1 2.2 1 1 1 2 2 2 0 Male sterility protein Pkinase_Tyr PF07714.12 ESA09675.1 - 9.2e-44 149.4 0.0 1.1e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09675.1 - 1.9e-39 135.3 0.0 2.3e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA09675.1 - 0.0024 17.2 0.2 0.0041 16.4 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA09675.1 - 0.046 12.6 0.0 0.079 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ESA09675.1 - 0.078 12.3 0.3 0.25 10.6 0.1 1.8 2 0 0 2 2 2 0 RIO1 family Methyltransf_23 PF13489.1 ESA09676.1 - 1.9e-09 37.4 0.0 3.2e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA09676.1 - 2e-05 24.9 0.1 0.00023 21.6 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA09676.1 - 0.001 19.5 0.0 0.0036 17.7 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Tub_2 PF04525.7 ESA09676.1 - 0.04 13.2 0.4 0.099 12.0 0.3 1.6 1 0 0 1 1 1 0 Tubby C 2 DUF3262 PF11660.3 ESA09676.1 - 0.073 13.1 0.1 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3262) Methyltransf_23 PF13489.1 ESA09677.1 - 1e-09 38.3 0.0 1.6e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA09677.1 - 1.1e-05 25.7 0.3 0.00013 22.3 0.0 2.7 3 1 1 4 4 4 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA09677.1 - 0.0005 20.5 0.0 0.0021 18.4 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Ion_trans PF00520.26 ESA09678.1 - 8.6e-12 44.7 16.4 8.6e-12 44.7 11.3 2.7 3 0 0 3 3 3 1 Ion transport protein IL10 PF00726.12 ESA09679.1 - 0.042 13.1 0.1 0.043 13.1 0.1 1.1 1 0 0 1 1 1 0 Interleukin 10 zf-B_box PF00643.19 ESA09679.1 - 0.23 11.3 2.4 0.35 10.7 0.4 1.9 2 0 0 2 2 2 0 B-box zinc finger MA3 PF02847.12 ESA09681.1 - 2e-05 24.2 0.5 2e-05 24.2 0.3 2.2 2 1 0 2 2 2 1 MA3 domain SlyX PF04102.7 ESA09681.1 - 0.0056 17.0 0.1 0.013 15.8 0.1 1.6 1 0 0 1 1 1 1 SlyX Lipase_GDSL PF00657.17 ESA09682.1 - 0.046 13.5 0.3 0.055 13.2 0.2 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Ank_2 PF12796.2 ESA09683.1 - 3e-13 49.9 0.1 1.1e-12 48.1 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESA09683.1 - 2.4e-12 46.0 2.4 2.7e-09 36.3 0.0 2.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 ESA09683.1 - 6.3e-12 44.5 1.1 3e-08 33.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESA09683.1 - 7.5e-12 45.4 1.7 2.6e-06 27.7 0.4 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA09683.1 - 7.5e-10 38.7 0.6 8.7e-07 29.0 0.1 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) TMEM51 PF15345.1 ESA09686.1 - 0.088 12.4 3.8 0.13 11.9 2.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2347 PF09804.4 ESA09686.1 - 0.12 11.6 5.0 0.24 10.6 3.4 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Shisa PF13908.1 ESA09686.1 - 0.21 11.7 4.8 0.41 10.7 3.3 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Band_3_cyto PF07565.8 ESA09686.1 - 0.63 9.4 5.7 0.93 8.9 3.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4175 PF13779.1 ESA09686.1 - 3.5 5.2 15.7 4.4 4.8 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1768 PF08719.6 ESA09687.1 - 3.8e-07 29.9 0.7 0.019 14.7 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF1768) THF_DHG_CYH PF00763.18 ESA09688.1 - 2.8e-20 72.5 0.1 5.7e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 ESA09688.1 - 6.2e-13 48.1 0.0 8.5e-09 34.6 0.0 2.9 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain IKI3 PF04762.7 ESA09689.1 - 3.9e-286 951.6 1.2 6.7e-286 950.8 0.8 1.3 1 0 0 1 1 1 1 IKI3 family EAP30 PF04157.11 ESA09691.1 - 0.00066 18.8 4.4 0.0024 17.0 3.0 2.0 2 0 0 2 2 2 1 EAP30/Vps36 family Cortex-I_coil PF09304.5 ESA09691.1 - 0.0012 18.8 7.2 0.0012 18.8 5.0 4.0 4 2 1 6 6 6 1 Cortexillin I, coiled coil Snapin_Pallidin PF14712.1 ESA09691.1 - 0.36 11.1 18.9 0.084 13.1 1.7 4.5 3 1 1 4 4 4 0 Snapin/Pallidin DUF464 PF04327.7 ESA09691.1 - 0.57 10.4 3.7 0.66 10.2 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF464) Striatin PF08232.7 ESA09691.1 - 1.3 9.3 13.3 0.09 13.0 4.7 2.4 2 1 0 2 2 2 0 Striatin family DUF1664 PF07889.7 ESA09691.1 - 2.2 8.0 16.4 0.47 10.2 3.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) BLYB PF05289.6 ESA09692.1 - 0.59 9.9 3.2 12 5.7 0.1 2.2 1 1 1 2 2 2 0 Borrelia hemolysin accessory protein Fun_ATP-synt_8 PF05933.8 ESA09692.1 - 6.6 6.8 7.0 1 9.4 1.9 1.7 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) DUF912 PF06024.7 ESA09694.1 - 0.082 12.9 0.1 0.095 12.7 0.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Zip PF02535.17 ESA09695.1 - 4.5e-41 140.8 12.1 9.7e-41 139.7 8.4 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter Cation_efflux PF01545.16 ESA09695.1 - 0.016 14.3 0.4 0.033 13.2 0.3 1.7 1 1 0 1 1 1 0 Cation efflux family TFIIS_M PF07500.9 ESA09696.1 - 2.1e-25 89.0 7.5 2.4e-25 88.8 5.2 1.1 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DUF1707 PF08044.6 ESA09696.1 - 0.014 15.1 0.2 0.064 13.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) GF_recep_IV PF14843.1 ESA09697.1 - 2.3e-06 27.2 58.1 0.00014 21.4 19.3 6.9 2 1 7 9 9 9 4 Growth factor receptor domain IV Laminin_EGF PF00053.19 ESA09697.1 - 0.0018 18.1 44.4 0.0021 17.9 12.2 9.6 2 2 6 8 8 8 2 Laminin EGF-like (Domains III and V) SIT PF15330.1 ESA09697.1 - 0.002 18.2 0.0 0.0049 17.0 0.0 1.7 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT hEGF PF12661.2 ESA09697.1 - 0.0038 17.2 2.5 0.0038 17.2 1.7 11.1 14 0 0 14 14 14 3 Human growth factor-like EGF Fer4_3 PF12798.2 ESA09697.1 - 0.0076 16.7 0.0 0.0076 16.7 0.0 10.7 10 3 0 10 10 10 2 4Fe-4S binding domain EGF_2 PF07974.8 ESA09697.1 - 0.01 15.9 15.1 0.01 15.9 10.5 12.4 7 3 1 9 9 9 0 EGF-like domain DUF1191 PF06697.7 ESA09697.1 - 0.042 12.6 0.0 0.072 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) Zn_Tnp_IS91 PF14319.1 ESA09698.1 - 0.14 11.6 2.3 0.17 11.4 1.6 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain GCC2_GCC3 PF07699.8 ESA09698.1 - 1.1 8.9 7.0 1.5 8.4 4.8 1.4 1 1 0 1 1 1 0 GCC2 and GCC3 zf-dskA_traR PF01258.12 ESA09698.1 - 8.2 6.2 6.9 1.7 8.4 0.2 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Pkinase_Tyr PF07714.12 ESA09699.1 - 1.6e-25 89.6 0.1 4.8e-25 88.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09699.1 - 5.9e-24 84.6 1.1 5.9e-24 84.6 0.8 1.8 2 1 0 2 2 2 1 Protein kinase domain BRAP2 PF07576.7 ESA09699.1 - 0.043 13.3 1.7 0.39 10.3 0.1 2.3 2 0 0 2 2 2 0 BRCA1-associated protein 2 PPP5 PF08321.7 ESA09699.1 - 0.087 12.8 0.3 12 5.9 0.1 2.5 2 0 0 2 2 2 0 PPP5 TPR repeat region APH PF01636.18 ESA09699.1 - 0.31 10.7 0.7 0.49 10.0 0.5 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_14 PF13173.1 ESA09702.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cu_bind_like PF02298.12 ESA09703.1 - 4.6e-08 32.7 0.0 6.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Plastocyanin-like domain Herpes_gp2 PF05955.6 ESA09704.1 - 0.025 13.9 0.3 0.045 13.0 0.2 1.4 1 1 1 2 2 2 0 Equine herpesvirus glycoprotein gp2 T4_baseplate PF12322.3 ESA09704.1 - 0.042 13.1 0.1 0.054 12.7 0.1 1.1 1 0 0 1 1 1 0 T4 bacteriophage base plate protein zf-C2H2_4 PF13894.1 ESA09704.1 - 0.6 10.5 0.1 0.6 10.5 0.1 3.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA09704.1 - 1.8 9.1 6.2 3.1 8.3 0.0 3.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type DUF4185 PF13810.1 ESA09705.1 - 0.038 12.8 0.0 0.059 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) DUF1935 PF09149.5 ESA09707.1 - 0.064 13.2 0.0 0.086 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1935) PH_10 PF15411.1 ESA09710.1 - 0.19 11.9 6.5 4.3 7.5 2.6 2.6 2 1 1 3 3 3 0 Pleckstrin homology domain Maff2 PF12750.2 ESA09711.1 - 0.087 12.3 0.1 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 Maff2 family DUF3545 PF12065.3 ESA09711.1 - 0.27 11.0 3.0 0.18 11.6 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3545) DUF496 PF04363.7 ESA09713.1 - 0.0057 16.4 0.7 0.0057 16.4 0.5 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF496) Colicin_Pyocin PF01320.13 ESA09713.1 - 0.091 12.6 7.0 8 6.4 0.1 4.0 3 1 1 4 4 4 0 Colicin immunity protein / pyocin immunity protein DUF3420 PF11900.3 ESA09713.1 - 0.52 10.4 5.2 0.75 9.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3420) TLD PF07534.11 ESA09714.1 - 7e-16 58.4 2.3 1.3e-15 57.5 1.6 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA09714.1 - 4.9e-12 45.8 0.6 2.9e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA09714.1 - 1.6e-07 31.0 0.1 2.7e-06 27.1 0.1 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch 2OG-FeII_Oxy_4 PF13661.1 ESA09715.1 - 0.07 12.7 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Thiolase_C PF02803.13 ESA09717.1 - 1.8e-43 146.8 0.7 2.5e-43 146.3 0.5 1.2 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 ESA09717.1 - 3.2e-27 95.1 0.1 3.2e-27 95.1 0.1 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain CENP-F_leu_zip PF10473.4 ESA09718.1 - 8 6.3 55.2 1.2 9.0 21.2 4.8 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Chitin_synth_2 PF03142.10 ESA09719.1 - 1.5e-255 848.6 0.4 2.2e-255 848.0 0.3 1.3 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 ESA09719.1 - 8.7e-188 625.5 10.0 1.1e-187 625.2 6.9 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Glyco_trans_2_3 PF13632.1 ESA09719.1 - 3.1e-20 72.7 3.7 5.2e-20 71.9 1.8 2.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA09719.1 - 6.9e-20 71.8 0.0 3e-17 63.1 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 ESA09719.1 - 5.3e-19 67.7 0.2 2e-12 46.7 0.0 3.8 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.6 ESA09719.1 - 3.5e-18 65.1 0.1 3.2e-17 62.0 0.2 2.4 2 0 0 2 2 2 1 DEK C terminal domain Glyco_transf_21 PF13506.1 ESA09719.1 - 3.1e-06 26.5 0.3 3.7e-05 23.0 0.0 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 ESA09719.1 - 0.00026 20.7 0.0 0.0012 18.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 AAA_22 PF13401.1 ESA09719.1 - 0.025 14.7 0.0 0.083 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpb4 PF03874.11 ESA09719.1 - 0.13 12.2 3.9 0.12 12.3 0.9 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb4 AAA_16 PF13191.1 ESA09719.1 - 0.14 12.1 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain F-box-like PF12937.2 ESA09721.1 - 1.8e-05 24.3 0.6 6.2e-05 22.6 0.4 1.9 1 0 0 1 1 1 1 F-box-like Nsp1_C PF05064.8 ESA09721.1 - 0.04 13.5 0.1 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Nsp1-like C-terminal region HAP1_N PF04849.8 ESA09726.1 - 9.1e-05 21.5 25.6 0.00039 19.4 17.7 2.0 1 1 0 1 1 1 1 HAP1 N-terminal conserved region Laminin_II PF06009.7 ESA09726.1 - 2.3 7.9 18.5 0.11 12.2 3.8 3.3 2 1 1 3 3 3 0 Laminin Domain II bZIP_2 PF07716.10 ESA09726.1 - 3.5 7.5 19.1 2.4 8.0 0.6 4.7 3 1 1 4 4 4 0 Basic region leucine zipper Pkinase_Tyr PF07714.12 ESA09727.1 - 8e-05 21.8 0.0 0.00012 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09727.1 - 0.041 13.0 0.1 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain DUF4220 PF13968.1 ESA09727.1 - 0.095 11.7 0.2 0.11 11.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF885 PF05960.6 ESA09727.1 - 0.096 11.8 0.2 0.1 11.7 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Cgr1 PF03879.9 ESA09727.1 - 0.15 12.2 2.2 0.27 11.4 1.6 1.3 1 1 0 1 1 1 0 Cgr1 family DUF4294 PF14127.1 ESA09729.1 - 0.0098 15.5 0.6 0.012 15.2 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) DUF1644 PF07800.7 ESA09729.1 - 0.055 13.3 1.3 0.069 12.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) BTB PF00651.26 ESA09730.1 - 1.1e-17 63.9 0.2 4.2e-17 62.1 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA09730.1 - 2.1e-12 46.7 0.7 4.6e-11 42.4 0.0 2.9 3 0 0 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA09731.1 - 8.3e-11 41.4 0.1 1.2e-07 31.0 0.1 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA09731.1 - 4.5e-09 35.8 0.5 5e-08 32.4 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA09731.1 - 0.044 13.5 0.1 0.062 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3097 PF11296.3 ESA09732.1 - 0.064 12.2 0.1 0.081 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) IF4E PF01652.13 ESA09733.1 - 2.9e-31 108.2 0.0 8.1e-31 106.7 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E ORC3_N PF07034.6 ESA09734.1 - 0.028 13.4 0.0 0.031 13.2 0.0 1.0 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus UNC45-central PF11701.3 ESA09734.1 - 0.069 12.7 0.0 0.086 12.4 0.0 1.1 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central Gpi16 PF04113.9 ESA09734.1 - 0.094 10.7 0.1 0.099 10.6 0.1 1.0 1 0 0 1 1 1 0 Gpi16 subunit, GPI transamidase component SRR PF07709.6 ESA09734.1 - 7.6 7.2 6.2 27 5.5 0.6 2.6 2 0 0 2 2 2 0 Seven Residue Repeat CLTH PF10607.4 ESA09735.1 - 3e-42 143.7 0.4 4e-42 143.3 0.3 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.6 ESA09735.1 - 6.9e-09 35.1 0.8 1.6e-08 33.9 0.2 1.9 2 0 0 2 2 2 1 LisH LuxE PF04443.7 ESA09735.1 - 0.04 12.6 0.4 0.068 11.8 0.2 1.4 1 1 0 1 1 1 0 Acyl-protein synthetase, LuxE DUF4258 PF14076.1 ESA09735.1 - 0.13 12.2 0.2 6 6.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4258) Vps35 PF03635.12 ESA09736.1 - 3.3e-177 591.0 3.3 4e-177 590.7 2.3 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Daxx PF03344.10 ESA09736.1 - 0.13 10.6 8.4 0.18 10.2 5.8 1.1 1 0 0 1 1 1 0 Daxx Family MRP-S25 PF13741.1 ESA09737.1 - 8.4e-44 149.7 0.1 1.1e-43 149.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 DUF924 PF06041.6 ESA09738.1 - 1e-54 185.1 0.0 1.2e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Renin_r PF07850.9 ESA09739.1 - 0.02 15.2 1.8 3.1 8.2 0.2 2.6 2 1 0 2 2 2 0 Renin receptor-like protein CRAL_TRIO PF00650.15 ESA09740.1 - 2e-31 108.6 0.3 3.8e-31 107.7 0.2 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESA09740.1 - 7.1e-09 35.6 1.7 9.1e-09 35.3 0.3 1.9 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESA09740.1 - 0.096 12.5 3.5 0.043 13.7 0.7 1.7 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain Antimicrobial10 PF08105.6 ESA09741.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Metchnikowin family RCR PF12273.3 ESA09741.1 - 4.4 7.8 7.2 24 5.4 5.0 1.9 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red RNase_H PF00075.19 ESA09742.1 - 1.4e-11 44.8 0.1 2.8e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.1 ESA09742.1 - 0.043 14.1 0.2 0.043 14.1 0.1 2.3 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase RNase_H PF00075.19 ESA09744.1 - 1.2e-15 58.0 0.0 2.6e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.1 ESA09744.1 - 0.056 13.2 0.2 0.27 11.0 0.1 2.2 1 1 0 1 1 1 0 Reverse transcriptase-like zf-RVT PF13966.1 ESA09744.1 - 0.064 13.5 0.2 0.064 13.5 0.1 2.4 2 1 0 2 2 2 0 zinc-binding in reverse transcriptase Lipase_GDSL_2 PF13472.1 ESA09745.1 - 3.8e-15 56.4 0.0 5e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 ESA09745.1 - 4.4e-12 46.3 0.0 7.3e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SPT2 PF08243.6 ESA09745.1 - 0.034 14.4 0.1 0.074 13.3 0.0 1.5 1 0 0 1 1 1 0 SPT2 chromatin protein FYRC PF05965.9 ESA09746.1 - 0.013 15.2 0.0 0.25 11.1 0.0 2.9 2 1 0 2 2 2 0 F/Y rich C-terminus Metallophos PF00149.23 ESA09747.1 - 1.8e-20 73.2 3.8 3.1e-20 72.4 2.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA09747.1 - 1.5e-13 50.8 0.0 2.1e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Reovirus_cap PF00979.12 ESA09747.1 - 0.00065 18.7 0.0 0.00098 18.1 0.0 1.2 1 0 0 1 1 1 1 Reovirus outer capsid protein, Sigma 3 Ter PF05472.6 ESA09747.1 - 0.14 11.2 0.0 10 5.1 0.0 2.1 2 0 0 2 2 2 0 DNA replication terminus site-binding protein (Ter protein) Fer4_12 PF13353.1 ESA09749.1 - 0.011 15.8 2.0 0.17 11.9 0.2 2.3 1 1 1 2 2 2 0 4Fe-4S single cluster domain MPLKIP PF15502.1 ESA09752.1 - 1.2e-05 26.1 25.8 1.8e-05 25.4 17.9 1.5 1 1 0 1 1 1 1 M-phase-specific PLK1-interacting protein PTS_2-RNA PF01885.11 ESA09753.1 - 4.2e-58 195.7 0.0 5.2e-58 195.4 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family BING4CT PF08149.6 ESA09755.1 - 2.5e-39 132.6 0.0 4.6e-38 128.6 0.0 2.9 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.27 ESA09755.1 - 7.4e-11 41.5 0.1 9.9e-07 28.4 0.0 5.1 6 0 0 6 6 6 1 WD domain, G-beta repeat AAA_11 PF13086.1 ESA09756.1 - 3.7e-29 101.9 0.4 2.3e-28 99.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 ESA09756.1 - 6.6e-27 94.1 0.0 2.3e-26 92.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA09756.1 - 2.7e-11 43.0 0.2 1.6e-09 37.3 0.0 2.3 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 ESA09756.1 - 1e-05 25.1 0.0 0.048 13.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 ESA09756.1 - 0.00042 20.2 0.0 0.00042 20.2 0.0 2.4 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 ESA09756.1 - 0.00045 19.6 0.0 0.0011 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 ESA09756.1 - 0.0026 17.2 0.1 0.018 14.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA PF00004.24 ESA09756.1 - 0.0037 17.4 0.0 0.019 15.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.1 ESA09756.1 - 0.0047 17.0 0.0 0.02 15.0 0.0 2.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 ESA09756.1 - 0.014 15.5 0.0 0.053 13.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA09756.1 - 0.034 14.0 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA09756.1 - 0.071 13.0 0.1 0.54 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Viral_helicase1 PF01443.13 ESA09756.1 - 0.077 12.5 0.0 4.6 6.6 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Zip PF02535.17 ESA09756.1 - 5.3 5.9 3.2 8.1 5.3 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_RNApol_7kD PF03604.8 ESA09757.1 - 1.8e-17 62.4 4.5 2.3e-17 62.1 3.1 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit TFIIS_C PF01096.13 ESA09757.1 - 0.0027 17.2 1.3 1.2 8.7 0.0 2.2 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) HypA PF01155.14 ESA09757.1 - 0.0057 16.3 0.7 0.0068 16.0 0.5 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family A2L_zn_ribbon PF08792.5 ESA09757.1 - 0.012 15.0 1.6 0.023 14.1 1.1 1.5 1 1 0 1 1 1 0 A2L zinc ribbon domain DZR PF12773.2 ESA09757.1 - 0.014 15.2 1.0 0.02 14.7 0.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 ESA09757.1 - 0.018 14.8 2.6 0.77 9.6 2.2 2.1 1 1 2 3 3 3 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 ESA09757.1 - 0.021 14.4 1.7 0.03 13.9 1.2 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-C3HC PF07967.8 ESA09757.1 - 0.023 14.4 0.3 0.025 14.3 0.2 1.1 1 0 0 1 1 1 0 C3HC zinc finger-like zf-ISL3 PF14690.1 ESA09757.1 - 0.038 14.0 2.0 0.038 14.0 0.2 1.8 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_ribbon_recom PF13408.1 ESA09757.1 - 0.049 13.9 2.7 0.22 11.8 0.3 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-trcl PF13451.1 ESA09757.1 - 0.05 13.2 1.7 3.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Probable zinc-binding domain Zn-ribbon_8 PF09723.5 ESA09757.1 - 0.088 12.7 4.0 0.5 10.3 2.7 2.0 1 1 0 1 1 1 0 Zinc ribbon domain zf-ribbon_3 PF13248.1 ESA09757.1 - 0.097 11.9 0.6 11 5.3 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.6 ESA09757.1 - 0.16 11.5 2.1 0.76 9.3 1.4 1.9 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_5 PF13719.1 ESA09757.1 - 0.18 11.3 2.0 1.3 8.6 1.4 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA09757.1 - 0.3 10.6 3.3 8.8 5.9 2.3 2.2 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ESA09757.1 - 0.46 10.2 2.9 4.1 7.1 2.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Cas_CXXC_CXXC PF09706.5 ESA09757.1 - 0.65 10.2 4.2 8 6.7 0.4 2.1 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) Ribosomal_L44 PF00935.14 ESA09757.1 - 1.6 8.7 5.2 2.6 8.0 1.2 2.1 1 1 1 2 2 2 0 Ribosomal protein L44 YhfH PF14149.1 ESA09757.1 - 3.5 7.5 6.6 5.9 6.7 0.5 2.3 1 1 1 2 2 2 0 YhfH-like protein Rad51 PF08423.6 ESA09758.1 - 7.5e-28 97.1 0.4 1e-27 96.6 0.3 1.2 1 0 0 1 1 1 1 Rad51 HHH_5 PF14520.1 ESA09758.1 - 5.3e-07 29.7 0.0 1.7e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain KaiC PF06745.8 ESA09758.1 - 0.00042 19.5 1.6 0.00063 18.9 0.6 1.6 2 0 0 2 2 2 1 KaiC RecA PF00154.16 ESA09758.1 - 0.00081 18.5 0.1 0.0009 18.3 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein PAXNEB PF05625.6 ESA09758.1 - 0.0026 16.6 0.1 0.0038 16.1 0.0 1.2 1 0 0 1 1 1 1 PAXNEB protein AAA_25 PF13481.1 ESA09758.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3808 PF10300.4 ESA09759.1 - 3.7e-20 71.9 0.1 3.7e-20 71.9 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_2 PF07719.12 ESA09759.1 - 0.0016 18.2 2.0 2.1 8.4 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA09759.1 - 0.0045 17.0 2.2 0.3 11.2 0.1 2.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF735 PF05246.6 ESA09759.1 - 0.16 11.7 1.9 0.19 11.4 0.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF735) TPR_1 PF00515.23 ESA09759.1 - 0.28 10.8 2.2 2.4 7.9 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2207 PF09972.4 ESA09760.1 - 0.0098 14.5 0.1 0.023 13.2 0.1 1.6 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Prefoldin_2 PF01920.15 ESA09760.1 - 0.033 13.9 0.3 0.053 13.2 0.2 1.3 1 0 0 1 1 1 0 Prefoldin subunit PB1 PF00564.19 ESA09761.1 - 0.073 12.7 0.1 0.45 10.2 0.1 2.1 2 0 0 2 2 2 0 PB1 domain DUF1168 PF06658.7 ESA09761.1 - 0.099 12.1 9.0 0.18 11.3 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PEN-2 PF10251.4 ESA09762.1 - 0.015 15.5 4.8 0.023 14.9 3.4 1.2 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase DinI PF06183.8 ESA09764.1 - 0.068 13.1 0.2 0.078 13.0 0.1 1.2 1 0 0 1 1 1 0 DinI-like family IncA PF04156.9 ESA09765.1 - 0.0015 18.1 3.6 0.003 17.1 2.5 1.4 1 0 0 1 1 1 1 IncA protein LLC1 PF14945.1 ESA09765.1 - 0.11 12.8 2.1 0.28 11.4 1.1 1.9 1 1 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein DUF1818 PF08848.6 ESA09765.1 - 0.44 10.6 3.7 0.82 9.7 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1818) DUF1635 PF07795.6 ESA09765.1 - 4.9 6.4 20.2 0.65 9.3 6.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) DUF3552 PF12072.3 ESA09765.1 - 7.5 5.7 16.3 2.2 7.4 9.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) GFA PF04828.9 ESA09767.1 - 3.3e-09 36.5 2.0 3.3e-09 36.5 1.4 1.8 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Ppx-GppA PF02541.11 ESA09768.1 - 3e-16 59.4 0.0 7.2e-16 58.2 0.0 1.6 1 1 0 1 1 1 1 Ppx/GppA phosphatase family DUF4478 PF14793.1 ESA09768.1 - 0.036 13.6 0.1 0.074 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4478) CsbD PF05532.7 ESA09769.1 - 0.00024 20.6 4.3 0.00024 20.6 3.0 2.5 2 0 0 2 2 2 1 CsbD-like DcuC PF03606.10 ESA09773.1 - 0.0079 14.4 0.0 0.0092 14.2 0.0 1.0 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier DUF3974 PF13120.1 ESA09773.1 - 0.0086 15.9 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3974) DUF2937 PF11157.3 ESA09773.1 - 0.075 12.3 0.2 0.12 11.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) EVC2_like PF12297.3 ESA09773.1 - 0.092 11.3 0.1 0.091 11.3 0.0 1.0 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Kri1 PF05178.7 ESA09773.1 - 0.11 12.8 1.0 0.16 12.2 0.7 1.2 1 0 0 1 1 1 0 KRI1-like family Erf4 PF10256.4 ESA09773.1 - 0.11 12.3 2.2 0.12 12.2 0.8 1.5 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family DUF4512 PF14975.1 ESA09773.1 - 3.6 8.4 4.8 1.2 10.0 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) TLD PF07534.11 ESA09774.1 - 3.6e-11 43.1 2.1 3.6e-11 43.1 1.4 1.5 2 0 0 2 2 2 1 TLD DUF4027 PF13219.1 ESA09775.1 - 0.05 13.0 1.0 0.16 11.4 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4027) DUF2119 PF09892.4 ESA09776.1 - 0.0018 17.5 1.6 0.0021 17.3 1.1 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2119) Moulting_cycle PF04870.11 ESA09776.1 - 0.043 12.9 0.5 0.043 12.8 0.4 1.0 1 0 0 1 1 1 0 Moulting cycle DUF4200 PF13863.1 ESA09776.1 - 0.68 9.8 5.8 0.8 9.6 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Peptidase_M54 PF07998.6 ESA09777.1 - 0.012 15.4 0.7 0.024 14.3 0.1 1.8 2 0 0 2 2 2 0 Peptidase family M54 DUF2305 PF10230.4 ESA09778.1 - 1.3e-66 224.7 0.1 1.5e-66 224.5 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 ESA09778.1 - 1.1e-11 45.0 0.0 2.1e-11 44.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA09778.1 - 0.00051 19.8 0.0 0.0015 18.3 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_9 PF10081.4 ESA09778.1 - 0.04 12.6 0.0 0.058 12.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Pkinase_Tyr PF07714.12 ESA09781.1 - 2.6e-17 62.7 0.1 3e-17 62.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09781.1 - 1.7e-16 60.1 0.1 2.2e-16 59.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain 2TM PF13239.1 ESA09781.1 - 0.0064 16.5 6.1 0.01 15.9 3.2 2.0 2 0 0 2 2 2 1 2TM domain Pox_A28 PF04584.9 ESA09781.1 - 0.44 10.4 5.6 2.1 8.2 1.1 2.2 2 0 0 2 2 2 0 Poxvirus A28 family LRR_4 PF12799.2 ESA09782.1 - 2.4 7.8 5.7 0.88 9.2 0.8 2.7 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA09782.1 - 3.6 7.4 7.9 1.8 8.4 1.9 2.9 3 0 0 3 3 3 0 Leucine rich repeat CtIP_N PF10482.4 ESA09783.1 - 0.029 14.1 1.8 6 6.6 0.1 2.4 1 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain zf-RVT PF13966.1 ESA09783.1 - 0.029 14.6 4.3 1.7 8.9 0.2 2.5 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase Zn_ribbon_2 PF12674.2 ESA09783.1 - 0.061 13.6 2.7 1.5 9.2 0.1 2.4 2 0 0 2 2 2 0 Putative zinc ribbon domain Cytochrom_c3_2 PF14537.1 ESA09783.1 - 0.25 11.7 1.4 0.62 10.4 0.8 1.8 1 1 1 2 2 2 0 Cytochrome c3 FYVE PF01363.16 ESA09783.1 - 0.43 10.5 8.7 3.3 7.6 0.9 2.5 3 0 0 3 3 3 0 FYVE zinc finger zf-C4pol PF14260.1 ESA09783.1 - 2.9 7.9 9.7 60 3.7 5.1 3.0 1 1 2 3 3 3 0 C4-type zinc-finger of DNA polymerase delta DUF2362 PF10154.4 ESA09784.1 - 1e-62 212.4 15.6 6.4e-38 130.6 0.3 2.3 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2362) UBA PF00627.26 ESA09784.1 - 3.7e-05 23.4 0.0 8.6e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 ESA09784.1 - 0.024 14.1 0.1 0.054 13.0 0.1 1.5 1 0 0 1 1 1 0 UBA-like domain DUF2363 PF10155.4 ESA09785.1 - 4.8e-30 104.0 1.2 3.6e-29 101.2 0.8 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) Rtt102p PF09510.5 ESA09786.1 - 0.032 14.2 2.0 0.044 13.7 0.5 1.8 1 1 0 2 2 2 0 Rtt102p-like transcription regulator protein FANCI_S1 PF14675.1 ESA09787.1 - 0.0003 20.2 0.0 0.00049 19.5 0.0 1.3 1 1 0 1 1 1 1 FANCI solenoid 1 zf-FPG_IleRS PF06827.9 ESA09789.1 - 0.27 10.9 3.7 11 5.8 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS RNA_pol_Rpb2_7 PF04560.15 ESA09789.1 - 0.38 11.0 4.3 10 6.4 0.2 3.0 2 1 1 3 3 3 0 RNA polymerase Rpb2, domain 7 TLD PF07534.11 ESA09790.1 - 1.8e-05 24.7 0.0 2e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 TLD DUF2457 PF10446.4 ESA09791.1 - 0.031 13.0 0.3 0.038 12.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TLD PF07534.11 ESA09792.1 - 2.2e-10 40.6 0.6 9.2e-10 38.6 0.4 2.0 1 1 0 1 1 1 1 TLD Cobalamin_bind PF01122.14 ESA09793.1 - 0.021 13.4 0.1 0.055 12.0 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein DUF3675 PF12428.3 ESA09793.1 - 0.021 15.0 2.5 0.035 14.3 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3675) DUF2702 PF10863.3 ESA09793.1 - 0.075 12.7 1.6 1.9 8.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2702) SAM_2 PF07647.12 ESA09797.1 - 4.2e-12 45.7 0.0 9.6e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA09797.1 - 1.4e-06 28.4 0.4 3.7e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) UQ_con PF00179.21 ESA09799.1 - 2.7e-41 140.2 0.0 3.2e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA09799.1 - 0.054 13.3 0.3 0.088 12.7 0.2 1.6 1 1 0 1 1 1 0 RWD domain Velvet PF11754.3 ESA09803.1 - 1.9e-34 119.0 0.1 2.1e-34 118.9 0.1 1.1 1 0 0 1 1 1 1 Velvet factor Copper-bind PF00127.15 ESA09804.1 - 1.3e-09 38.1 0.6 1.6e-09 37.9 0.4 1.1 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu_bind_like PF02298.12 ESA09804.1 - 1.6e-07 30.9 0.5 2.2e-07 30.5 0.3 1.2 1 0 0 1 1 1 1 Plastocyanin-like domain Cu-oxidase_3 PF07732.10 ESA09804.1 - 0.0024 17.6 0.1 0.005 16.5 0.0 1.5 2 0 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.1 ESA09804.1 - 0.009 15.8 0.2 0.018 14.9 0.1 1.5 1 1 0 1 1 1 1 Cupredoxin-like domain Cu-oxidase_2 PF07731.9 ESA09804.1 - 0.03 13.8 0.1 0.047 13.1 0.1 1.4 1 1 0 1 1 1 0 Multicopper oxidase Cpn10 PF00166.16 ESA09804.1 - 0.043 13.7 0.1 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Chaperonin 10 Kd subunit Acetyltransf_3 PF13302.1 ESA09805.1 - 3.1e-15 56.5 0.0 3.8e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA09805.1 - 1.4e-07 31.6 0.3 1.7e-07 31.2 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA09805.1 - 0.0015 18.4 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FBD PF08387.5 ESA09808.1 - 0.12 11.8 1.1 8.7 5.8 0.1 3.7 4 0 0 4 4 4 0 FBD STE3 PF02076.10 ESA09809.1 - 1.6e-55 188.1 15.1 2e-55 187.8 10.5 1.1 1 0 0 1 1 1 1 Pheromone A receptor Pkinase PF00069.20 ESA09811.1 - 3.5e-08 32.8 0.0 4.5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09811.1 - 6.7e-07 28.6 0.0 8.4e-07 28.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-bind_6 PF13921.1 ESA09811.1 - 0.063 13.3 0.1 0.095 12.8 0.1 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain Piwi PF02171.12 ESA09812.1 - 3.4e-95 318.4 0.2 6.1e-95 317.6 0.1 1.4 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA09812.1 - 2.6e-15 55.8 2.0 5.7e-15 54.8 0.1 2.3 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ESA09812.1 - 7.2e-10 38.0 0.0 1.4e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) VWA PF00092.23 ESA09812.1 - 0.064 12.9 0.1 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Bax1-I PF01027.15 ESA09813.1 - 3.8e-17 62.5 21.8 4.7e-17 62.2 15.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 p450 PF00067.17 ESA09814.1 - 2.9e-74 250.2 0.6 3.5e-74 249.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 RED_N PF07808.8 ESA09815.1 - 1.3e-47 162.0 8.5 1.3e-47 162.0 5.9 2.6 2 1 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.6 ESA09815.1 - 9.9e-28 96.7 9.9 9.9e-28 96.7 6.8 3.8 4 0 0 4 4 4 1 RED-like protein C-terminal region DUF1444 PF07285.6 ESA09815.1 - 0.06 12.6 3.0 0.14 11.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1444) MMR_HSR1 PF01926.18 ESA09816.1 - 6.9e-21 74.3 0.0 1.9e-20 72.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA09816.1 - 1.9e-12 46.7 0.0 5.4e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESA09816.1 - 3.9e-11 42.7 0.4 2e-09 37.1 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESA09816.1 - 5.6e-09 36.0 2.4 1.5e-05 24.8 0.2 2.8 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.11 ESA09816.1 - 3.5e-07 29.5 0.9 4.4e-07 29.2 0.0 1.6 2 0 0 2 2 2 1 AIG1 family KH_2 PF07650.12 ESA09816.1 - 6.5e-07 28.8 0.0 1.7e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 KH domain Miro PF08477.8 ESA09816.1 - 6.6e-07 29.8 0.1 3e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein cobW PF02492.14 ESA09816.1 - 0.00019 20.9 0.0 0.032 13.6 0.0 2.3 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 ESA09816.1 - 0.00038 19.6 0.0 0.0011 18.2 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 ESA09816.1 - 0.00074 19.0 0.0 0.0034 16.8 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family ATP_bind_1 PF03029.12 ESA09816.1 - 0.00098 18.7 0.0 0.065 12.7 0.0 2.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Arf PF00025.16 ESA09816.1 - 0.0029 16.8 2.9 0.025 13.8 0.1 2.8 2 1 0 2 2 2 1 ADP-ribosylation factor family PduV-EutP PF10662.4 ESA09816.1 - 0.0094 15.4 0.0 0.041 13.3 0.0 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.1 ESA09816.1 - 0.013 15.4 0.1 0.025 14.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF4615 PF15393.1 ESA09816.1 - 0.02 15.1 2.3 0.044 14.0 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4615) AAA_18 PF13238.1 ESA09816.1 - 0.091 13.0 2.1 0.3 11.4 0.0 2.8 3 1 0 3 3 3 0 AAA domain DUF3357 PF11837.3 ESA09818.1 - 0.028 14.2 0.5 0.057 13.2 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) DUF3328 PF11807.3 ESA09818.1 - 0.029 14.0 0.2 0.039 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) ETRAMP PF09716.5 ESA09818.1 - 0.073 13.0 0.1 0.42 10.6 0.0 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) zf-DHHC PF01529.15 ESA09818.1 - 0.48 9.7 2.3 0.66 9.3 1.6 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase RXT2_N PF08595.6 ESA09821.1 - 0.073 12.8 2.3 0.079 12.7 1.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.7 ESA09821.1 - 2.6 7.2 6.9 3 7.0 4.8 1.1 1 0 0 1 1 1 0 NOA36 protein Kinesin-relat_1 PF12711.2 ESA09822.1 - 0.15 12.4 2.8 0.22 11.9 1.9 1.4 1 1 0 1 1 1 0 Kinesin motor Sel1 PF08238.7 ESA09823.1 - 1.2e-15 57.6 13.6 3.9e-07 30.4 1.2 4.5 5 0 0 5 5 5 2 Sel1 repeat TPR_11 PF13414.1 ESA09823.1 - 0.0036 16.9 13.0 0.034 13.7 0.4 3.3 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.1 ESA09823.1 - 0.0056 17.0 5.4 3.4 8.3 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA09823.1 - 0.0083 16.4 6.5 0.03 14.6 0.2 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA09823.1 - 0.016 15.3 2.6 0.13 12.5 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.1 ESA09823.1 - 0.057 12.4 2.5 0.11 11.5 0.9 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA09823.1 - 0.066 13.9 4.9 6.4 7.5 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA09823.1 - 0.078 13.6 1.1 0.94 10.2 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA09823.1 - 1.7 8.3 9.1 5.7 6.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA09823.1 - 2.8 8.1 8.4 22 5.2 0.4 3.0 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ACPS PF01648.15 ESA09824.1 - 1.5e-15 56.9 0.0 1.4e-12 47.4 0.0 2.4 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase superfamily Maf1 PF09174.5 ESA09824.1 - 0.0021 17.9 0.7 0.0029 17.4 0.2 1.5 2 0 0 2 2 2 1 Maf1 regulator Pribosyltran PF00156.22 ESA09825.1 - 5.5e-17 61.6 0.2 8e-17 61.1 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 ESA09825.1 - 0.0041 16.3 0.0 0.0068 15.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 ESA09825.1 - 0.052 12.8 0.0 0.09 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase DUF4201 PF13870.1 ESA09827.1 - 0.0011 18.3 14.6 0.0011 18.3 10.1 4.0 3 2 0 4 4 4 1 Domain of unknown function (DUF4201) TMF_TATA_bd PF12325.3 ESA09827.1 - 0.0031 17.2 4.0 0.0031 17.2 2.8 4.4 2 1 1 4 4 4 2 TATA element modulatory factor 1 TATA binding ApbE PF02424.10 ESA09827.1 - 0.092 12.0 0.1 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 ApbE family Cytochrom_C_2 PF01322.15 ESA09827.1 - 0.69 10.4 3.6 28 5.2 0.6 2.8 2 0 0 2 2 2 0 Cytochrome C' Matrilin_ccoil PF10393.4 ESA09827.1 - 1.3 8.4 12.7 0.44 9.9 0.7 3.6 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Myb_DNA-bind_4 PF13837.1 ESA09828.1 - 5e-07 29.7 0.3 6.5e-07 29.3 0.2 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Hormone_6 PF00236.13 ESA09829.1 - 0.053 13.3 0.1 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycoprotein hormone Post_transc_reg PF13797.1 ESA09830.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Post-transcriptional regulator BTB PF00651.26 ESA09831.1 - 0.0035 17.3 0.3 0.0079 16.1 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain ER PF01133.12 ESA09831.1 - 0.085 12.5 0.2 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 Enhancer of rudimentary Histone PF00125.19 ESA09832.1 - 1.3e-24 86.0 0.0 1.8e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA09832.1 - 3.7e-05 23.7 0.0 5.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Myb_DNA-bind_4 PF13837.1 ESA09836.1 - 9.8e-10 38.4 0.0 1.2e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA09836.1 - 0.06 13.2 0.1 0.067 13.0 0.1 1.2 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA09836.1 - 0.072 13.2 0.2 0.093 12.8 0.2 1.3 1 1 0 1 1 1 0 Myb-like DNA-binding domain PriCT_2 PF08707.6 ESA09836.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Primase C terminal 2 (PriCT-2) NOB1_Zn_bind PF08772.6 ESA09837.1 - 0.051 13.4 0.6 0.089 12.6 0.4 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF4187 PF13821.1 ESA09838.1 - 2.1 7.9 6.2 0.61 9.7 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4187) His_Phos_2 PF00328.17 ESA09840.1 - 9.8e-31 107.3 0.2 1.1e-30 107.1 0.2 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF21 PF01595.15 ESA09841.1 - 7.3e-38 129.6 0.4 1.1e-37 129.1 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESA09841.1 - 2.1e-10 40.2 0.5 3e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 CBS domain CRA PF06589.6 ESA09843.1 - 0.001 18.4 8.1 0.0016 17.7 0.1 2.8 2 1 1 3 3 3 1 Circumsporozoite-related antigen (CRA) Snapin_Pallidin PF14712.1 ESA09843.1 - 0.0032 17.7 0.8 0.0032 17.7 0.6 2.9 4 0 0 4 4 4 1 Snapin/Pallidin TACC PF05010.9 ESA09843.1 - 0.01 15.6 2.6 0.085 12.6 1.8 2.2 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Kin17_mid PF10357.4 ESA09843.1 - 0.03 13.9 0.6 0.075 12.6 0.4 1.8 1 1 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein ECM11 PF15463.1 ESA09843.1 - 0.063 13.5 2.1 0.13 12.5 0.0 2.6 3 0 0 3 3 3 0 Extracellular mutant protein 11 LPP20 PF02169.11 ESA09843.1 - 0.17 11.9 4.1 0.13 12.3 0.3 2.2 2 0 0 2 2 2 0 LPP20 lipoprotein EAP30 PF04157.11 ESA09843.1 - 0.33 10.0 3.9 0.16 11.1 0.5 1.9 2 0 0 2 2 2 0 EAP30/Vps36 family Fib_alpha PF08702.5 ESA09843.1 - 1.3 9.0 12.7 0.46 10.6 1.0 2.8 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF2681 PF10883.3 ESA09843.1 - 8.4 6.6 7.7 2.1 8.6 2.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2743 PF10899.3 ESA09844.1 - 0.00032 20.1 0.4 0.00041 19.7 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2743) F-protein PF00469.15 ESA09844.1 - 0.002 17.5 1.8 0.0025 17.2 1.3 1.1 1 0 0 1 1 1 1 Negative factor, (F-Protein) or Nef FAM117 PF15388.1 ESA09844.1 - 0.15 11.2 4.9 0.17 11.0 3.4 1.1 1 0 0 1 1 1 0 Protein Family FAM117 UDPGT PF00201.13 ESA09845.1 - 0.00046 18.8 0.0 0.0036 15.9 0.0 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Apolipoprotein PF01442.13 ESA09846.1 - 4.4e-05 23.0 27.2 0.00016 21.2 6.7 3.3 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 ESA09846.1 - 0.00012 21.9 30.8 0.0057 16.4 4.0 4.2 1 1 2 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.8 ESA09846.1 - 0.0012 19.1 22.0 0.23 11.9 0.0 5.9 1 1 5 7 7 7 2 Bacterial protein of unknown function (DUF883) SF-assemblin PF06705.6 ESA09846.1 - 0.0013 17.9 14.6 0.0013 17.9 10.1 3.0 1 1 3 4 4 4 1 SF-assemblin/beta giardin ApoO PF09769.4 ESA09846.1 - 0.0022 17.7 20.2 0.46 10.1 2.0 5.4 1 1 3 4 4 4 2 Apolipoprotein O LEA_4 PF02987.11 ESA09846.1 - 0.0026 17.5 1.5 0.54 10.1 0.5 3.5 3 0 0 3 3 3 1 Late embryogenesis abundant protein DUF2533 PF10752.4 ESA09846.1 - 0.0093 16.2 15.9 0.81 10.0 0.3 4.8 2 2 3 5 5 5 2 Protein of unknown function (DUF2533) IDO PF01231.13 ESA09846.1 - 0.011 14.2 1.2 0.011 14.2 0.8 3.1 1 1 2 3 3 3 0 Indoleamine 2,3-dioxygenase DUF1970 PF09301.5 ESA09846.1 - 0.1 12.6 0.5 0.63 10.0 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1970) YtxH PF12732.2 ESA09846.1 - 0.23 11.8 0.2 0.23 11.8 0.1 6.1 2 1 0 2 2 1 0 YtxH-like protein Pollen_allerg_2 PF01620.11 ESA09846.1 - 0.24 11.7 2.9 0.84 9.9 0.5 2.8 3 0 0 3 3 3 0 Ribonuclease (pollen allergen) AIP3 PF03915.8 ESA09846.1 - 0.88 8.4 31.3 0.79 8.5 3.5 3.1 1 1 0 2 2 2 0 Actin interacting protein 3 Metal_resist PF13801.1 ESA09846.1 - 1 9.3 4.5 6.4 6.7 0.2 3.3 2 1 1 3 3 3 0 Heavy-metal resistance DUF2422 PF10337.4 ESA09846.1 - 4.9 5.8 14.5 0.12 11.0 1.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2422) DUF1451 PF07295.6 ESA09846.1 - 6.5 6.5 23.8 1.9 8.2 2.0 4.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1451) Hrs_helical PF12210.3 ESA09846.1 - 6.7 7.0 16.5 0.57 10.4 1.0 4.8 1 1 4 6 6 6 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Helicase_IV_N PF12462.3 ESA09846.1 - 6.8 6.3 9.1 3.2 7.3 0.2 3.3 1 1 2 3 3 3 0 DNA helicase IV / RNA helicase N terminal 5_3_exonuc PF01367.15 ESA09846.1 - 7.5 6.8 8.3 1.2 9.4 0.3 3.2 2 1 1 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold HisKA_3 PF07730.8 ESA09846.1 - 8.4 6.8 13.1 21 5.5 0.0 5.6 3 2 4 7 7 7 0 Histidine kinase Phasin PF05597.6 ESA09846.1 - 8.4 6.1 28.4 1.4 8.7 0.5 5.6 1 1 5 6 6 6 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TLD PF07534.11 ESA09847.1 - 0.00051 20.0 2.8 0.0013 18.7 1.9 1.7 1 1 0 1 1 1 1 TLD HTH_23 PF13384.1 ESA09850.1 - 4.5e-08 32.5 0.3 8.2e-08 31.6 0.2 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 ESA09850.1 - 0.0017 18.2 0.1 0.0026 17.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.1 ESA09850.1 - 0.007 16.5 0.1 0.0096 16.0 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_7 PF02796.10 ESA09850.1 - 0.012 15.4 0.1 0.053 13.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.7 ESA09850.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 PAX PF00292.13 ESA09850.1 - 0.071 12.8 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain DDE_3 PF13358.1 ESA09851.1 - 1.4e-05 24.8 0.0 1.6e-05 24.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease HOOK PF05622.7 ESA09853.1 - 8.2e-50 169.3 77.4 3.3e-27 94.6 45.8 2.7 1 1 1 2 2 2 2 HOOK protein HsbA PF12296.3 ESA09853.1 - 0.011 15.6 1.8 0.035 13.9 0.1 2.8 1 1 1 2 2 2 0 Hydrophobic surface binding protein A WD40 PF00400.27 ESA09854.1 - 1.1e-20 72.7 4.8 0.00018 21.2 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat VBS PF08913.5 ESA09856.1 - 0.084 13.1 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Vinculin Binding Site DUF3212 PF11486.3 ESA09857.1 - 0.00085 19.0 0.9 0.0075 16.0 0.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3212) MIF4G_like_2 PF09090.6 ESA09857.1 - 0.012 14.8 5.5 0.0095 15.1 3.2 1.3 1 1 0 1 1 1 0 MIF4G like DUF4610 PF15384.1 ESA09857.1 - 0.015 14.8 2.8 0.018 14.6 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4610) NAP PF00956.13 ESA09857.1 - 0.019 14.1 5.3 0.08 12.0 3.7 2.0 1 1 0 1 1 1 0 Nucleosome assembly protein (NAP) TRAPPC-Trs85 PF12739.2 ESA09857.1 - 0.021 13.5 0.1 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SurA_N_2 PF13623.1 ESA09857.1 - 0.05 13.5 0.7 0.05 13.5 0.5 2.3 1 1 1 2 2 2 0 SurA N-terminal domain DUF1843 PF08898.5 ESA09857.1 - 0.077 13.0 0.7 0.077 13.0 0.5 2.6 2 2 0 2 2 2 0 Domain of unknown function (DUF1843) V_ATPase_I PF01496.14 ESA09857.1 - 0.099 10.4 6.6 0.11 10.3 4.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2492 PF10678.4 ESA09857.1 - 0.17 11.9 1.1 0.34 10.9 0.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2492) Rep_trans PF02486.14 ESA09857.1 - 0.38 10.2 3.2 0.35 10.3 1.5 1.4 1 1 0 1 1 1 0 Replication initiation factor RTBV_P46 PF06216.6 ESA09857.1 - 0.72 8.6 5.8 0.33 9.7 1.2 2.1 1 1 2 3 3 3 0 Rice tungro bacilliform virus P46 protein Prominin PF05478.6 ESA09857.1 - 0.79 7.1 7.9 0.51 7.8 4.4 1.4 1 1 0 1 1 1 0 Prominin PMC2NT PF08066.7 ESA09857.1 - 1 9.6 4.6 19 5.6 0.1 2.7 2 1 1 3 3 3 0 PMC2NT (NUC016) domain Pkinase PF00069.20 ESA09858.1 - 1.5e-22 80.0 0.0 3.2e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.17 ESA09858.1 - 1.6e-17 61.9 0.4 0.004 17.0 0.0 6.0 6 0 0 6 6 6 4 HEAT repeat HEAT_2 PF13646.1 ESA09858.1 - 8.5e-09 35.5 0.0 0.0071 16.6 0.0 3.9 2 2 2 4 4 4 4 HEAT repeats Pkinase_Tyr PF07714.12 ESA09858.1 - 1e-07 31.2 0.0 2e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.2 ESA09858.1 - 1.5e-07 31.4 5.1 0.16 11.8 0.0 5.2 5 0 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESA09858.1 - 0.00015 22.1 0.1 0.049 14.1 0.1 3.9 3 0 0 3 3 3 1 HEAT-like repeat DUF2435 PF10363.4 ESA09858.1 - 0.00074 19.3 0.1 2.3 8.1 0.0 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF2435) Nipped-B_C PF12830.2 ESA09858.1 - 0.0021 17.7 0.2 0.21 11.2 0.0 3.2 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus CLASP_N PF12348.3 ESA09858.1 - 0.019 14.3 0.1 0.32 10.3 0.0 2.7 2 1 1 3 3 3 0 CLASP N terminal Pkinase_Tyr PF07714.12 ESA09859.1 - 9.6e-37 126.4 0.0 2.1e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09859.1 - 2.1e-34 118.8 0.1 4.9e-34 117.6 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA09859.1 - 0.0058 16.3 0.4 0.0093 15.7 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family MA3 PF02847.12 ESA09860.1 - 0.29 10.8 2.2 1.4 8.6 0.1 2.6 2 1 1 3 3 3 0 MA3 domain F-box-like PF12937.2 ESA09861.1 - 0.0013 18.4 5.5 0.0046 16.6 1.5 2.6 2 0 0 2 2 2 1 F-box-like cwf18 PF08315.7 ESA09861.1 - 0.026 14.9 0.1 0.037 14.4 0.1 1.3 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor GST_C PF00043.20 ESA09863.1 - 1.6e-15 56.8 0.1 1.3e-14 53.8 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA09863.1 - 1.2e-13 50.9 0.0 3.1e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 ESA09863.1 - 3.1e-13 49.7 0.0 5.4e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA09863.1 - 3.9e-12 45.9 0.0 8e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA09863.1 - 3.1e-09 36.5 0.0 5.3e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA09863.1 - 8.9e-09 35.7 0.0 1.5e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain BTB PF00651.26 ESA09865.1 - 8.9e-19 67.5 0.5 1.1e-18 67.1 0.4 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA09865.1 - 0.0073 15.4 0.8 0.009 15.1 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Lactamase_B_2 PF12706.2 ESA09866.1 - 0.015 14.8 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Beta-lactamase superfamily domain HMG_box PF00505.14 ESA09866.1 - 0.13 12.5 0.5 3.8 7.8 0.0 2.1 2 0 0 2 2 2 0 HMG (high mobility group) box RPAP3_C PF13877.1 ESA09867.1 - 0.085 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 DUF3194 PF11419.3 ESA09868.1 - 0.05 13.8 0.4 0.085 13.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) DUF1433 PF07252.6 ESA09868.1 - 0.092 12.9 0.7 0.15 12.2 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1433) Methyltransf_33 PF10017.4 ESA09869.1 - 0.037 13.8 0.1 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Fer4_12 PF13353.1 ESA09872.1 - 0.53 10.3 3.2 0.75 9.9 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S single cluster domain Tol_Tol_Ttg2 PF05494.7 ESA09873.1 - 0.033 13.7 0.1 0.035 13.6 0.1 1.2 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 FTA4 PF13093.1 ESA09873.1 - 0.037 13.4 0.4 0.043 13.2 0.3 1.0 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Ribosomal_S13 PF00416.17 ESA09873.1 - 0.16 12.4 0.4 0.5 10.8 0.2 1.7 1 1 0 1 1 1 0 Ribosomal protein S13/S18 Pneumo_M2 PF07380.6 ESA09875.1 - 0.092 12.7 1.8 0.14 12.1 1.3 1.4 1 1 0 1 1 1 0 Pneumovirus M2 protein HMG_box PF00505.14 ESA09876.1 - 0.00029 21.0 0.3 0.00048 20.3 0.2 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09876.1 - 0.0065 16.8 0.4 0.0095 16.2 0.3 1.3 1 0 0 1 1 1 1 HMG-box domain Ribonucleas_3_2 PF11469.3 ESA09876.1 - 0.091 12.9 0.1 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribonuclease III HMG_box PF00505.14 ESA09877.1 - 1.9e-05 24.8 0.2 3.2e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box Cid2 PF09774.4 ESA09877.1 - 0.012 15.7 0.3 3.2 7.8 0.0 2.3 2 1 0 2 2 2 0 Caffeine-induced death protein 2 HMG_box_2 PF09011.5 ESA09877.1 - 0.035 14.4 0.0 0.056 13.8 0.0 1.4 1 1 0 1 1 1 0 HMG-box domain Toxin_10 PF05431.6 ESA09878.1 - 0.085 12.4 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 CAP_C PF08603.6 ESA09882.1 - 7.7e-09 35.0 9.8 7.7e-09 35.0 6.8 1.4 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.7 ESA09882.1 - 0.052 12.9 5.5 0.15 11.4 3.8 1.7 1 1 0 1 1 1 0 Tubulin binding cofactor C DNA_pol3_beta_3 PF02768.10 ESA09882.1 - 0.063 12.8 0.4 0.063 12.8 0.3 1.9 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain DDHD PF02862.12 ESA09882.1 - 0.15 11.8 3.8 0.24 11.1 2.7 1.3 1 0 0 1 1 1 0 DDHD domain Med5 PF08689.5 ESA09884.1 - 5.7e-14 50.8 2.7 1.9e-12 45.7 1.8 2.1 1 1 0 1 1 1 1 Mediator complex subunit Med5 Med24_N PF11277.3 ESA09884.1 - 2.3e-05 22.1 0.1 2.5e-05 22.0 0.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal TLD PF07534.11 ESA09885.1 - 0.1 12.6 0.1 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 TLD CUE PF02845.11 ESA09887.1 - 1.9e-11 43.2 0.1 3.1e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 CUE domain Thiol_cytolysin PF01289.14 ESA09887.1 - 0.041 12.2 0.0 0.041 12.2 0.0 1.0 1 0 0 1 1 1 0 Thiol-activated cytolysin ubiquitin PF00240.18 ESA09888.1 - 2.2e-18 65.4 0.4 2.2e-18 65.4 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 ESA09888.1 - 2e-08 33.7 0.4 3.6e-08 32.9 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA09888.1 - 4.4e-05 23.6 0.4 0.00015 21.9 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA09888.1 - 0.00041 20.1 0.2 0.004 17.0 0.1 2.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CDK2AP PF09806.4 ESA09888.1 - 0.097 12.8 3.8 0.18 12.0 2.6 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Lycopene_cycl PF05834.7 ESA09888.1 - 0.13 11.1 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein PseudoU_synth_2 PF00849.17 ESA09890.1 - 7.3e-18 64.9 0.0 1.4e-17 63.9 0.0 1.5 2 0 0 2 2 2 1 RNA pseudouridylate synthase NAC PF01849.13 ESA09890.1 - 0.069 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 NAC domain GDE_N PF12439.3 ESA09891.1 - 0.01 15.1 1.9 0.018 14.2 1.3 1.4 1 0 0 1 1 1 0 Glycogen debranching enzyme N terminal Spc24 PF08286.6 ESA09891.1 - 0.99 9.1 13.1 0.54 9.9 1.8 2.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 TMPIT PF07851.8 ESA09891.1 - 2.6 7.0 13.2 0.025 13.6 1.9 2.2 2 0 0 2 2 2 0 TMPIT-like protein MCR_C PF04609.7 ESA09893.1 - 2.2e-05 23.4 0.1 3e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Methyl-coenzyme M reductase operon protein C MutS_V PF00488.16 ESA09896.1 - 4.8e-91 304.3 0.0 7.3e-91 303.7 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESA09896.1 - 1.9e-44 151.9 0.0 4.9e-44 150.5 0.0 1.8 1 1 0 1 1 1 1 MutS domain III MutS_I PF01624.15 ESA09896.1 - 1.9e-35 121.3 0.1 6.7e-35 119.5 0.1 2.1 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 ESA09896.1 - 2.5e-15 56.7 0.1 4.6e-14 52.6 0.0 3.0 2 1 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 ESA09896.1 - 4.7e-12 45.9 1.7 1.4e-11 44.3 1.2 1.9 1 0 0 1 1 1 1 MutS family domain IV DUF948 PF06103.6 ESA09896.1 - 0.05 13.4 0.1 0.28 11.0 0.0 2.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Coq4 PF05019.8 ESA09897.1 - 5e-86 287.2 0.0 5.5e-86 287.0 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Pribosyltran PF00156.22 ESA09898.1 - 6.8e-11 41.9 0.2 1.7e-10 40.6 0.1 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Na_Ca_ex PF01699.19 ESA09899.1 - 6.8e-28 97.0 20.0 5.9e-16 58.3 4.6 3.4 5 0 0 5 5 5 2 Sodium/calcium exchanger protein DUF307 PF03733.8 ESA09899.1 - 1.8e-11 44.2 9.6 1.8e-11 44.2 6.7 3.5 2 0 0 2 2 2 1 Domain of unknown function (DUF307) Myc_N PF01056.13 ESA09899.1 - 2.2 7.3 8.9 1.2 8.2 0.8 2.3 2 0 0 2 2 2 0 Myc amino-terminal region PGA2 PF07543.7 ESA09899.1 - 8.9 6.1 9.2 14 5.5 0.7 2.5 2 0 0 2 2 2 0 Protein trafficking PGA2 Myosin_head PF00063.16 ESA09900.1 - 4.7e-234 778.5 4.7 7.2e-234 777.8 3.3 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 ESA09900.1 - 2.8e-45 154.0 0.1 7e-45 152.7 0.1 1.7 1 0 0 1 1 1 1 Myosin tail SH3_1 PF00018.23 ESA09900.1 - 1.3e-15 56.4 0.6 3.2e-15 55.2 0.4 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA09900.1 - 6.8e-14 51.1 0.2 2.3e-12 46.2 0.0 2.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.1 ESA09900.1 - 6.2e-13 48.1 1.4 2e-12 46.4 0.2 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.6 ESA09900.1 - 0.00019 21.5 0.1 0.00049 20.2 0.1 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain Hpr_kinase_C PF07475.7 ESA09900.1 - 0.0039 16.5 0.3 1.9 7.7 0.0 2.4 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain AAA_22 PF13401.1 ESA09900.1 - 0.0047 17.0 0.1 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA09900.1 - 0.015 14.4 0.0 0.037 13.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.1 ESA09900.1 - 0.017 15.9 0.3 0.096 13.5 0.0 2.5 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.1 ESA09900.1 - 0.043 14.1 0.0 0.29 11.4 0.0 2.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA09900.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 ESA09900.1 - 0.15 11.6 0.1 0.42 10.2 0.1 1.7 1 0 0 1 1 1 0 NACHT domain DUF566 PF04484.7 ESA09901.1 - 2.7e-08 33.7 9.0 5.2e-08 32.7 6.2 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF566) Tox-REase-9 PF15650.1 ESA09902.1 - 0.19 11.9 4.6 0.58 10.3 0.1 3.0 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 9 FLO_LFY PF01698.11 ESA09903.1 - 0.81 8.4 9.5 0.94 8.2 6.6 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Mem_trans PF03547.13 ESA09903.1 - 2.7 6.1 4.4 3.3 5.8 3.1 1.1 1 0 0 1 1 1 0 Membrane transport protein NSP2-B_epitope PF14757.1 ESA09904.1 - 0.13 11.6 0.4 0.14 11.5 0.3 1.0 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein IGPD PF00475.13 ESA09905.1 - 9.9e-61 203.8 0.2 1.3e-60 203.4 0.1 1.1 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Peptidase_M48 PF01435.13 ESA09906.1 - 4.3e-55 186.7 0.0 6.8e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M13 PF01431.16 ESA09906.1 - 0.008 15.3 0.1 0.015 14.5 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M13 UPF0104 PF03706.8 ESA09906.1 - 0.023 13.9 8.6 0.24 10.6 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0104) Peptidase_M56 PF05569.6 ESA09906.1 - 0.17 10.8 3.2 0.16 10.9 1.1 1.8 2 1 0 2 2 2 0 BlaR1 peptidase M56 DUF4538 PF15061.1 ESA09906.1 - 0.23 10.7 1.1 0.71 9.2 0.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) DUF1634 PF07843.6 ESA09906.1 - 0.41 10.3 8.0 0.23 11.0 2.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1634) Kelch_5 PF13854.1 ESA09908.1 - 1.1e-09 38.0 0.0 0.00049 19.9 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA09908.1 - 6.7e-08 31.9 0.1 0.00012 21.6 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 ESA09908.1 - 2.9e-05 24.1 0.0 0.26 11.4 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA09908.1 - 8.9e-05 22.1 0.1 0.0021 17.7 0.0 2.5 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA09908.1 - 0.00027 20.4 1.1 0.32 10.5 0.0 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA09908.1 - 0.0073 16.4 1.2 0.42 10.8 0.0 2.8 3 0 0 3 3 3 1 Kelch motif GHMP_kinases_N PF00288.21 ESA09911.1 - 2.5e-12 46.6 0.1 6.6e-12 45.3 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESA09911.1 - 1.9e-09 37.5 0.0 6.4e-09 35.8 0.0 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal DUF663 PF04950.7 ESA09912.1 - 4.5e-92 308.1 0.5 4.5e-92 308.1 0.3 3.4 5 0 0 5 5 3 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 ESA09912.1 - 4.5e-31 106.2 0.1 2.1e-30 104.1 0.0 2.3 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 ESA09912.1 - 3.2e-06 26.7 5.4 0.00011 21.6 0.0 3.5 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 ESA09912.1 - 0.00012 22.1 0.0 0.0013 18.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESA09912.1 - 0.00034 20.3 0.2 0.001 18.8 0.1 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.4 ESA09912.1 - 0.00095 18.6 0.5 0.0043 16.5 0.1 2.2 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 ESA09912.1 - 0.0013 18.7 0.0 0.0032 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.17 ESA09912.1 - 0.0026 17.9 0.4 0.016 15.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA PF00004.24 ESA09912.1 - 0.0031 17.6 0.1 0.0031 17.6 0.1 2.7 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA09912.1 - 0.0078 17.0 0.0 0.0078 17.0 0.0 4.5 4 2 0 4 4 3 1 AAA domain Miro PF08477.8 ESA09912.1 - 0.0097 16.4 0.0 0.0097 16.4 0.0 2.7 3 0 0 3 3 3 1 Miro-like protein AAA_33 PF13671.1 ESA09912.1 - 0.038 13.8 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESA09912.1 - 0.038 13.9 0.2 0.038 13.9 0.1 3.4 4 1 0 4 4 3 0 50S ribosome-binding GTPase AAA_14 PF13173.1 ESA09912.1 - 0.043 13.7 0.0 0.043 13.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 ESA09912.1 - 0.088 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain BAH PF01426.13 ESA09913.1 - 5.2e-22 77.8 1.6 1e-21 76.9 1.1 1.5 1 0 0 1 1 1 1 BAH domain Bromodomain PF00439.20 ESA09913.1 - 2.5e-21 75.4 0.9 8.8e-21 73.6 0.6 2.0 1 0 0 1 1 1 1 Bromodomain Glyco_transf_9 PF01075.12 ESA09915.1 - 0.0025 17.0 0.0 0.0036 16.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Pkinase_Tyr PF07714.12 ESA09916.1 - 0.0003 19.9 0.0 0.00053 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4101 PF13355.1 ESA09916.1 - 0.21 11.9 6.6 2.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4101) ABC2_membrane PF01061.19 ESA09918.1 - 2.3e-23 82.4 7.9 3.1e-23 82.0 5.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.1 ESA09918.1 - 0.0023 17.9 1.2 0.015 15.2 0.2 2.1 2 0 0 2 2 2 1 AAA domain ER_lumen_recept PF00810.13 ESA09918.1 - 0.026 15.0 1.9 0.14 12.6 1.3 2.0 1 1 0 1 1 1 0 ER lumen protein retaining receptor ABC_tran PF00005.22 ESA09918.1 - 0.037 14.3 0.6 0.07 13.4 0.0 1.8 2 1 0 2 2 2 0 ABC transporter ABC2_membrane_3 PF12698.2 ESA09918.1 - 0.065 12.2 7.7 0.025 13.6 3.4 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_15 PF13175.1 ESA09918.1 - 0.07 12.1 2.1 0.074 12.0 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain zf-C2H2 PF00096.21 ESA09921.1 - 0.0042 17.3 0.2 0.016 15.4 0.2 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA09921.1 - 0.016 15.5 1.3 0.045 14.1 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 ESA09921.1 - 0.057 13.6 0.3 0.057 13.6 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Imm8 PF15560.1 ESA09921.1 - 0.058 13.0 0.9 0.099 12.3 0.7 1.3 1 0 0 1 1 1 0 Immunity protein 8 DUF2375 PF09558.5 ESA09921.1 - 0.12 12.1 0.0 7.6 6.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2375) zf-C2H2_jaz PF12171.3 ESA09921.1 - 0.23 11.6 3.8 0.29 11.3 0.2 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding A_deamin PF02137.13 ESA09923.1 - 0.0088 15.4 0.2 0.01 15.2 0.1 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Vps16_C PF04840.7 ESA09923.1 - 0.019 13.9 1.2 0.02 13.8 0.8 1.1 1 0 0 1 1 1 0 Vps16, C-terminal region Glyco_hydro_2 PF00703.16 ESA09923.1 - 0.07 13.5 0.4 0.098 13.1 0.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 Myb_DNA-bind_3 PF12776.2 ESA09923.1 - 1.3 9.6 9.2 1.7 9.3 2.1 2.2 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF1104 PF06518.6 ESA09923.1 - 4.4 7.4 9.1 0.96 9.6 3.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) ICMT PF04140.9 ESA09924.1 - 4.1e-11 42.9 3.5 1.1e-10 41.5 1.1 2.0 1 1 1 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESA09924.1 - 1.3e-06 28.4 6.7 5.5e-06 26.4 1.2 2.2 2 0 0 2 2 2 2 Phospholipid methyltransferase Chordopox_A35R PF05989.7 ESA09924.1 - 0.046 13.3 0.2 0.065 12.8 0.2 1.2 1 0 0 1 1 1 0 Chordopoxvirus A35R protein Pkinase_Tyr PF07714.12 ESA09925.1 - 8.1e-17 61.1 0.0 1.3e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09925.1 - 6e-14 51.8 0.5 1.4e-13 50.6 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain DKNYY PF13644.1 ESA09925.1 - 0.03 14.5 4.2 0.019 15.2 1.8 1.5 2 0 0 2 2 2 0 DKNYY family 7TM_transglut PF14402.1 ESA09925.1 - 0.18 10.6 0.1 0.23 10.3 0.1 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase Pkinase_Tyr PF07714.12 ESA09926.1 - 1.2e-05 24.4 0.1 1.5e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09926.1 - 4.3e-05 22.7 0.5 4.6e-05 22.6 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF960 PF06124.6 ESA09926.1 - 0.086 13.1 1.8 0.12 12.6 1.2 1.2 1 0 0 1 1 1 0 Staphylococcal protein of unknown function (DUF960) DUF2439 PF10382.4 ESA09926.1 - 0.19 11.9 2.1 0.33 11.1 1.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2439) Pkinase_Tyr PF07714.12 ESA09928.1 - 0.0017 17.4 0.1 0.0029 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09928.1 - 0.097 11.8 0.1 0.21 10.7 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09929.1 - 7.3e-19 67.8 0.0 9.9e-19 67.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09929.1 - 2.4e-15 56.4 0.0 4e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF1258 PF06869.7 ESA09929.1 - 0.016 14.3 2.0 0.024 13.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Pkinase PF00069.20 ESA09930.1 - 2.2e-14 53.2 0.1 3.2e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09930.1 - 1.2e-13 50.7 0.0 1.6e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09932.1 - 0.00077 18.6 0.2 0.0009 18.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09932.1 - 0.037 13.0 0.1 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase TPR_7 PF13176.1 ESA09933.1 - 3e-05 23.4 4.3 1.9 8.4 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Sgf11 PF08209.6 ESA09933.1 - 0.00071 18.8 0.1 9.3 5.6 0.0 3.6 3 0 0 3 3 3 1 Sgf11 (transcriptional regulation protein) DUF750 PF04721.12 ESA09933.1 - 0.00094 19.1 0.0 13 5.9 0.0 5.3 3 2 0 3 3 3 1 Domain of unknown function (DUF750) DUF2361 PF10153.4 ESA09933.1 - 0.033 14.3 17.9 1.2 9.3 0.1 5.6 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2361) Prenyltrans PF00432.16 ESA09933.1 - 0.054 13.0 0.7 36 4.0 0.0 4.5 5 0 0 5 5 5 0 Prenyltransferase and squalene oxidase repeat DUF1836 PF08876.6 ESA09933.1 - 1.1 9.0 22.4 2.3 8.0 0.6 5.3 4 1 0 5 5 5 0 Domain of unknown function (DUF1836) zf-TAZ PF02135.11 ESA09933.1 - 1.8 8.6 6.2 36 4.4 0.1 4.1 4 0 0 4 4 4 0 TAZ zinc finger TPR_3 PF07720.7 ESA09933.1 - 2.2 8.1 11.8 36 4.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Tup_N PF08581.5 ESA09933.1 - 2.2 8.5 25.1 3.6 7.8 0.2 5.7 6 1 0 6 6 6 0 Tup N-terminal TPR_8 PF13181.1 ESA09933.1 - 4 7.4 14.9 5 7.1 0.4 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DDE_1 PF03184.14 ESA09934.1 - 1.4e-15 57.0 0.8 1.5e-15 56.9 0.5 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA09934.1 - 0.068 12.9 0.1 0.07 12.8 0.1 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease DEAD PF00270.24 ESA09935.1 - 2.7e-18 66.0 0.0 6.1e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA09935.1 - 1.5e-15 56.8 0.0 2e-14 53.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA09935.1 - 1.8e-06 27.9 0.1 5.9e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RQC PF09382.5 ESA09935.1 - 2.7e-06 27.0 0.0 8.8e-06 25.3 0.0 1.9 1 0 0 1 1 1 1 RQC domain PBP1_TM PF14812.1 ESA09937.1 - 2.8 8.3 7.6 1.3 9.3 1.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyoxal_oxid_N PF07250.6 ESA09938.1 - 9.9e-47 159.0 0.0 1.2e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxal oxidase N-terminus UPF0147 PF03685.8 ESA09940.1 - 0.073 12.9 0.1 17 5.3 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) Tubulin_C PF03953.12 ESA09940.1 - 0.082 12.9 0.8 18 5.3 0.0 3.0 2 1 1 3 3 3 0 Tubulin C-terminal domain Pkinase_Tyr PF07714.12 ESA09940.1 - 0.084 11.9 0.0 2.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase DENN PF02141.16 ESA09944.1 - 2.2e-54 184.0 2.1 4.1e-54 183.1 1.5 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 ESA09944.1 - 9.6e-20 70.3 0.9 2.5e-19 69.0 0.6 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.14 ESA09944.1 - 9.4e-15 54.4 0.9 2.7e-14 52.9 0.6 1.8 1 0 0 1 1 1 1 dDENN domain C1_1 PF00130.17 ESA09944.1 - 0.00026 20.6 0.7 0.00046 19.8 0.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_3 PF07649.7 ESA09944.1 - 0.0014 18.6 2.6 0.003 17.5 1.8 1.6 1 0 0 1 1 1 1 C1-like domain PHD PF00628.24 ESA09944.1 - 0.14 11.8 1.6 0.33 10.6 1.1 1.6 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.11 ESA09944.1 - 0.76 9.9 4.3 0.23 11.6 0.7 1.9 1 1 1 2 2 2 0 C1 domain zf-RING_2 PF13639.1 ESA09944.1 - 0.78 9.6 5.8 2 8.3 4.0 1.7 1 0 0 1 1 1 0 Ring finger domain Pkinase_Tyr PF07714.12 ESA09945.1 - 0.00089 18.4 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase zf-MYND PF01753.13 ESA09946.1 - 0.019 14.8 8.1 0.019 14.8 5.6 1.9 2 1 0 2 2 2 0 MYND finger Acyl-CoA_dh_1 PF00441.19 ESA09948.1 - 9.6e-41 139.3 0.0 1.5e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESA09948.1 - 1.6e-36 125.3 0.0 2.9e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 ESA09948.1 - 1.7e-19 69.0 0.0 3.3e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESA09948.1 - 5.2e-11 42.9 0.0 1.3e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.1 ESA09948.1 - 0.13 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal F1F0-ATPsyn_F PF10791.4 ESA09949.1 - 1.4e-19 70.0 0.9 1.6e-19 69.8 0.6 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 ESA09949.1 - 0.0026 17.7 0.1 0.0033 17.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f APG9 PF04109.11 ESA09950.1 - 1.8e-161 537.1 7.4 2.2e-161 536.8 5.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Adeno_E3B PF03376.9 ESA09950.1 - 3.9 7.4 6.9 0.85 9.5 0.7 2.5 2 0 0 2 2 2 0 Adenovirus E3B protein UQ_con PF00179.21 ESA09951.1 - 2e-51 173.1 0.0 2.2e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA09951.1 - 1.6e-05 24.6 0.0 1.9e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA09951.1 - 8.7e-05 22.3 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA09951.1 - 0.0017 18.0 0.1 0.0024 17.5 0.1 1.2 1 0 0 1 1 1 1 UEV domain tRNA_NucTran2_2 PF13735.1 ESA09952.1 - 0.12 12.2 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative TLD PF07534.11 ESA09953.1 - 4.3e-14 52.6 1.1 1.1e-13 51.4 0.7 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA09953.1 - 2.4e-06 27.3 1.9 3.9e-05 23.4 0.7 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA09954.1 - 6.1e-16 58.6 0.5 1.1e-15 57.8 0.4 1.3 1 0 0 1 1 1 1 TLD EF-hand_7 PF13499.1 ESA09955.1 - 7.7e-20 70.8 19.9 3.6e-07 30.2 2.1 3.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ESA09955.1 - 9.1e-17 59.0 16.9 9.8e-05 21.3 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESA09955.1 - 1.7e-14 52.2 13.9 0.0011 18.6 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESA09955.1 - 2.4e-10 39.2 14.3 0.0012 18.1 0.2 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 ESA09955.1 - 6e-10 38.5 10.3 0.0097 15.4 0.5 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 ESA09955.1 - 4.5e-07 29.5 3.3 0.046 13.4 0.1 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA09955.1 - 7.1e-07 29.2 0.1 0.00036 20.5 0.0 2.7 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region SieB PF14163.1 ESA09955.1 - 0.031 13.8 0.1 0.05 13.1 0.1 1.2 1 0 0 1 1 1 0 Superinfection exclusion protein B EF-hand_10 PF14788.1 ESA09955.1 - 0.096 12.3 4.9 1.1 9.0 0.1 3.3 3 1 1 4 4 4 0 EF hand Ten1_2 PF15490.1 ESA09955.1 - 0.12 11.9 0.2 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit DUF605 PF04652.11 ESA09957.1 - 8.3 5.6 11.3 11 5.2 7.8 1.1 1 0 0 1 1 1 0 Vta1 like Ion_trans PF00520.26 ESA09958.1 - 2.7e-105 349.9 86.8 5.2e-36 123.7 11.0 5.1 5 0 0 5 5 5 4 Ion transport protein PKD_channel PF08016.7 ESA09958.1 - 0.072 11.5 77.3 0.017 13.5 2.6 6.1 5 2 2 7 7 7 0 Polycystin cation channel PAP2 PF01569.16 ESA09959.1 - 2e-21 76.0 5.6 2e-21 76.0 3.9 1.8 2 1 0 2 2 2 1 PAP2 superfamily Acylphosphatase PF00708.13 ESA09960.1 - 1.9e-22 79.1 0.4 2e-22 79.0 0.3 1.0 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.3 ESA09960.1 - 0.15 12.1 0.2 0.21 11.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) Pkinase PF00069.20 ESA09962.1 - 2.6e-25 89.0 0.1 2.6e-25 89.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA09962.1 - 4.8e-24 84.8 0.0 7.7e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ArsA_ATPase PF02374.10 ESA09962.1 - 0.0011 18.1 0.5 0.0014 17.7 0.4 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase DUF2130 PF09903.4 ESA09962.1 - 0.0018 17.1 3.5 0.05 12.3 2.3 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2130) DivIC PF04977.10 ESA09962.1 - 0.0042 16.5 0.8 0.011 15.2 0.6 1.7 1 0 0 1 1 1 1 Septum formation initiator Kdo PF06293.9 ESA09962.1 - 0.0049 15.9 0.1 0.0077 15.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA09962.1 - 0.011 15.5 0.0 0.31 10.7 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family FliD_C PF07195.7 ESA09962.1 - 0.013 14.7 2.0 0.021 14.1 1.4 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Prefoldin PF02996.12 ESA09962.1 - 0.025 14.2 3.4 0.051 13.2 2.4 1.5 1 0 0 1 1 1 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.4 ESA09962.1 - 0.032 14.2 1.0 0.07 13.1 0.7 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FlxA PF14282.1 ESA09962.1 - 0.035 14.0 6.4 0.063 13.2 4.4 1.4 1 0 0 1 1 1 0 FlxA-like protein YchF-GTPase_C PF06071.8 ESA09962.1 - 0.043 13.5 0.1 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF933) ApoB100_C PF12491.3 ESA09962.1 - 0.047 13.3 1.9 0.17 11.5 1.3 1.9 1 0 0 1 1 1 0 Apolipoprotein B100 C terminal Synaptobrevin PF00957.16 ESA09962.1 - 0.053 13.1 0.9 0.13 11.8 0.6 1.7 1 0 0 1 1 1 0 Synaptobrevin AKNA PF12443.3 ESA09962.1 - 0.3 11.1 5.2 0.23 11.4 1.2 2.1 2 0 0 2 2 2 0 AT-hook-containing transcription factor YtxH PF12732.2 ESA09962.1 - 0.39 11.1 1.5 0.86 10.0 1.0 1.6 1 0 0 1 1 1 0 YtxH-like protein Phage_GP20 PF06810.6 ESA09962.1 - 2.1 7.7 11.5 6.5 6.1 0.1 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 Tyr-DNA_phospho PF06087.7 ESA09965.1 - 9.2e-56 189.3 0.0 1.1e-42 146.2 0.0 2.2 2 0 0 2 2 2 2 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 ESA09965.1 - 0.0003 20.5 3.0 0.072 12.8 0.1 3.0 2 1 0 2 2 2 2 PLD-like domain Cyclin_N PF00134.18 ESA09966.1 - 4.9e-10 39.0 0.1 7.4e-08 32.0 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Pkinase_Tyr PF07714.12 ESA09967.1 - 1.8e-45 155.0 0.0 2.3e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA09967.1 - 1.1e-42 145.9 2.4 4.2e-42 144.1 0.2 2.4 2 1 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA09967.1 - 0.0056 16.4 0.1 0.0089 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA09967.1 - 0.018 14.1 0.3 0.033 13.2 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MUG113 PF13455.1 ESA09968.1 - 2.7e-21 75.7 0.6 7.6e-21 74.3 0.4 1.8 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 ESA09968.1 - 3.6e-16 59.4 0.3 1.1e-15 57.8 0.2 1.9 1 0 0 1 1 1 1 T5orf172 domain zf-primase PF09329.6 ESA09968.1 - 0.075 12.6 6.7 3.3 7.3 0.3 2.7 2 0 0 2 2 2 0 Primase zinc finger MAD PF05557.8 ESA09969.1 - 4.7e-47 160.5 102.3 3e-46 157.8 71.4 1.6 1 1 0 1 1 1 1 Mitotic checkpoint protein APG6 PF04111.7 ESA09969.1 - 0.0056 15.7 19.5 0.0056 15.7 13.5 5.6 2 1 2 5 5 5 1 Autophagy protein Apg6 DUF4200 PF13863.1 ESA09969.1 - 0.02 14.8 1.3 0.02 14.8 0.9 8.6 3 1 5 8 8 8 0 Domain of unknown function (DUF4200) BTB PF00651.26 ESA09970.1 - 1.1e-17 63.9 1.5 3.2e-17 62.5 0.2 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA09970.1 - 1.1e-11 44.8 0.1 2.2e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA09970.1 - 0.0052 16.6 4.2 0.02 14.7 0.1 3.5 4 0 0 4 4 4 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA09970.1 - 0.034 13.2 0.0 0.061 12.3 0.0 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Dynamitin PF04912.9 ESA09971.1 - 2.7e-63 214.1 24.9 3.2e-63 213.8 17.2 1.0 1 0 0 1 1 1 1 Dynamitin TBCA PF02970.11 ESA09971.1 - 0.0038 17.2 1.0 0.0038 17.2 0.7 3.5 4 1 0 4 4 4 1 Tubulin binding cofactor A DUF3450 PF11932.3 ESA09971.1 - 0.025 13.8 0.5 0.025 13.8 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) DUF4041 PF13250.1 ESA09971.1 - 0.029 13.9 0.3 2.3 7.8 0.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4041) CHASE3 PF05227.8 ESA09971.1 - 0.26 10.9 6.0 0.45 10.1 0.7 3.0 2 2 0 2 2 2 0 CHASE3 domain Snapin_Pallidin PF14712.1 ESA09971.1 - 1.5 9.2 20.4 0.56 10.5 0.2 4.2 4 1 0 4 4 3 0 Snapin/Pallidin PspB PF06667.7 ESA09971.1 - 1.8 8.5 0.0 1.8 8.5 0.0 4.2 4 1 1 5 5 5 0 Phage shock protein B MerR-DNA-bind PF09278.6 ESA09971.1 - 3.8 7.9 8.3 30 5.0 0.0 4.4 4 1 1 5 5 5 0 MerR, DNA binding Allexi_40kDa PF05549.6 ESA09971.1 - 5.6 6.1 15.9 0.33 10.1 2.4 3.2 2 1 1 3 3 3 0 Allexivirus 40kDa protein NPV_P10 PF05531.7 ESA09971.1 - 6.3 7.1 15.8 40 4.5 0.6 5.3 3 3 1 4 4 4 0 Nucleopolyhedrovirus P10 protein L31 PF09784.4 ESA09971.1 - 7.5 6.6 6.8 0.95 9.5 0.2 2.8 3 1 1 4 4 4 0 Mitochondrial ribosomal protein L31 IncA PF04156.9 ESA09971.1 - 7.9 6.0 19.5 0.12 11.9 1.8 3.4 3 1 0 3 3 3 0 IncA protein DASH_Dam1 PF08653.5 ESA09971.1 - 8.2 6.2 6.9 22 4.9 0.1 4.0 2 1 2 4 4 4 0 DASH complex subunit Dam1 Methyltransf_4 PF02390.12 ESA09972.1 - 4e-58 195.7 0.0 4.9e-58 195.4 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESA09972.1 - 2.8e-05 24.6 0.0 4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA09972.1 - 0.00058 19.4 0.0 0.0008 19.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA09972.1 - 0.0027 17.0 0.0 0.0087 15.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESA09972.1 - 0.011 16.0 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESA09972.1 - 0.016 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.8 ESA09972.1 - 0.017 14.4 0.1 0.11 11.7 0.0 1.9 1 1 0 2 2 2 0 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 ESA09972.1 - 0.031 14.3 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 ESA09972.1 - 0.085 11.5 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_11 PF08241.7 ESA09972.1 - 0.11 12.9 0.0 0.55 10.7 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain AAA PF00004.24 ESA09973.1 - 6.7e-19 68.4 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA09973.1 - 2.6e-06 28.2 0.3 8.1e-06 26.6 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA09973.1 - 3.1e-05 24.0 0.9 0.0002 21.4 0.0 2.3 1 1 2 3 3 3 1 AAA ATPase domain Zot PF05707.7 ESA09973.1 - 9.8e-05 21.9 0.2 0.0089 15.5 0.1 2.4 2 1 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_22 PF13401.1 ESA09973.1 - 0.00043 20.4 3.6 0.0019 18.3 0.0 2.5 2 1 1 3 3 2 1 AAA domain AAA_5 PF07728.9 ESA09973.1 - 0.00057 19.6 0.0 0.0012 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESA09973.1 - 0.00065 19.3 0.1 0.0019 17.8 0.0 1.8 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 ESA09973.1 - 0.00081 19.7 0.2 0.0021 18.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESA09973.1 - 0.0019 18.1 0.0 0.0065 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ESA09973.1 - 0.0085 15.1 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Mg_chelatase PF01078.16 ESA09973.1 - 0.011 14.8 0.2 0.038 13.1 0.1 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 ESA09973.1 - 0.012 15.5 0.0 0.12 12.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain Vps36_ESCRT-II PF11605.3 ESA09973.1 - 0.031 14.0 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 TIP49 PF06068.8 ESA09973.1 - 0.035 12.8 0.0 0.056 12.1 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus AAA_28 PF13521.1 ESA09973.1 - 0.037 14.0 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 ESA09973.1 - 0.037 13.6 0.0 0.079 12.5 0.0 1.3 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESA09973.1 - 0.044 13.4 0.2 2.2 7.9 0.0 2.4 1 1 1 2 2 2 0 NTPase IstB_IS21 PF01695.12 ESA09973.1 - 0.044 13.1 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF3121 PF11319.3 ESA09973.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3121) AAA_33 PF13671.1 ESA09973.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain PAP2 PF01569.16 ESA09974.1 - 5.9e-24 84.1 0.4 7.6e-24 83.8 0.3 1.1 1 0 0 1 1 1 1 PAP2 superfamily Kelch_4 PF13418.1 ESA09975.1 - 2.5e-17 62.3 8.8 0.00047 19.8 0.0 5.9 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09975.1 - 2.7e-13 49.4 7.6 0.031 14.4 0.0 6.0 6 0 0 6 6 5 4 Kelch motif Kelch_1 PF01344.20 ESA09975.1 - 4.4e-13 48.5 7.9 0.0012 18.3 0.1 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 ESA09975.1 - 1.6e-10 40.7 2.6 6.2e-05 22.8 0.0 4.3 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA09975.1 - 3.7e-10 39.1 0.6 0.092 12.5 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA09975.1 - 1.6e-08 34.4 9.5 0.0094 16.0 0.1 5.9 6 1 0 6 6 6 2 Galactose oxidase, central domain TMEM154 PF15102.1 ESA09975.1 - 0.0042 16.7 2.1 0.007 16.0 0.9 1.6 1 1 0 1 1 1 1 TMEM154 protein family ETRAMP PF09716.5 ESA09975.1 - 0.0092 15.9 0.7 0.054 13.4 0.0 2.3 2 0 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) Epiglycanin_C PF14654.1 ESA09975.1 - 0.01 15.8 0.0 0.029 14.3 0.0 1.9 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region Sigma_reg_N PF13800.1 ESA09975.1 - 0.029 14.3 1.4 0.11 12.5 1.0 2.0 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3139 PF11337.3 ESA09975.1 - 0.059 13.6 2.5 0.16 12.2 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Shisa PF13908.1 ESA09975.1 - 0.15 12.2 1.0 0.25 11.4 0.7 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Rifin_STEVOR PF02009.11 ESA09975.1 - 5.2 6.6 6.7 0.65 9.5 1.7 1.6 2 0 0 2 2 2 0 Rifin/stevor family RWD PF05773.17 ESA09976.1 - 6e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 0 0 1 1 1 1 RWD domain HMG_box PF00505.14 ESA09977.1 - 7.6e-07 29.3 1.4 1.4e-06 28.4 0.4 1.9 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09977.1 - 1.7e-05 25.1 1.2 2.2e-05 24.7 0.6 1.4 1 1 0 1 1 1 1 HMG-box domain Sel1 PF08238.7 ESA09978.1 - 1.9e-43 145.9 27.1 3.3e-10 40.2 0.2 5.3 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA09978.1 - 0.096 13.1 7.1 5.2 7.7 0.0 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA09978.1 - 1.2 9.0 12.4 3.1 7.7 0.2 4.1 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain HMG_box PF00505.14 ESA09979.1 - 1e-09 38.4 0.0 1.7e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA09979.1 - 0.063 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 HMG-box domain Aminotran_5 PF00266.14 ESA09980.1 - 1.3e-30 106.4 0.0 9.3e-30 103.5 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Dimer_Tnp_hAT PF05699.9 ESA09982.1 - 3.4e-15 55.4 0.0 3.5e-15 55.3 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4298 PF14131.1 ESA09985.1 - 0.011 15.5 4.7 0.12 12.3 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) BTB PF00651.26 ESA09986.1 - 2.4e-16 59.7 0.2 5.7e-16 58.4 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA09986.1 - 0.032 14.0 1.1 1.6 8.5 0.0 3.1 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF1247 PF06851.6 ESA09986.1 - 4.6 6.8 8.8 3 7.4 3.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1247) ATS3 PF06232.6 ESA09987.1 - 0.069 12.7 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Embryo-specific protein 3, (ATS3) CDK2AP PF09806.4 ESA09987.1 - 0.075 13.2 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein MMR_HSR1 PF01926.18 ESA09988.1 - 0.00012 22.0 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.13 ESA09988.1 - 0.028 13.4 0.3 0.068 12.1 0.2 1.7 1 1 0 1 1 1 0 Septin AAA_22 PF13401.1 ESA09988.1 - 0.028 14.5 0.0 0.068 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF3997 PF13162.1 ESA09988.1 - 0.047 13.5 0.1 0.097 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3997) DUF258 PF03193.11 ESA09988.1 - 0.052 12.7 0.0 0.14 11.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA09988.1 - 0.072 13.9 0.2 0.19 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESA09988.1 - 0.76 9.5 2.5 0.89 9.3 0.1 2.2 2 1 1 3 3 3 0 Domain of unknown function DUF87 Pkinase PF00069.20 ESA09989.1 - 7.3e-10 38.4 0.0 7.3e-10 38.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA09989.1 - 0.016 14.1 0.0 0.016 14.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like DUF1310 PF07006.6 ESA09989.1 - 0.06 12.8 0.0 0.066 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Pkinase_Tyr PF07714.12 ESA09989.1 - 0.1 11.6 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Steroid_dh PF02544.11 ESA09990.1 - 3.3e-41 140.5 4.5 1.4e-28 99.5 0.7 2.3 2 0 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase MipA PF06629.7 ESA09990.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 MltA-interacting protein MipA DUF1295 PF06966.7 ESA09990.1 - 0.09 12.0 1.0 0.19 11.0 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) UPF0220 PF05255.6 ESA09990.1 - 0.16 11.1 1.4 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0220) PEMT PF04191.8 ESA09990.1 - 1.5 8.9 6.0 3.5 7.7 0.0 2.7 3 1 0 3 3 3 0 Phospholipid methyltransferase WD40 PF00400.27 ESA09991.1 - 1e-41 139.3 10.7 3.8e-10 39.2 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA09991.1 - 4e-09 36.4 0.1 0.0034 17.1 0.0 3.4 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.9 ESA09991.1 - 0.00044 19.1 0.6 0.17 10.6 0.0 3.0 2 1 0 3 3 3 1 Coatomer WD associated region IKI3 PF04762.7 ESA09991.1 - 0.00062 17.7 3.8 0.061 11.1 0.1 3.3 2 2 1 4 4 4 2 IKI3 family PD40 PF07676.7 ESA09991.1 - 0.017 14.8 0.0 2.1 8.0 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 ESA09991.1 - 0.021 13.1 0.0 0.21 9.8 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF3312 PF11768.3 ESA09991.1 - 0.049 11.8 0.0 7.3 4.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3312) COesterase PF00135.23 ESA09992.1 - 7.1e-27 94.3 0.0 1e-26 93.8 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 ESA09992.1 - 6e-26 91.3 0.0 8.1e-26 90.9 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA09992.1 - 3.7e-15 55.9 0.0 5.3e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESA09992.1 - 1.2e-07 31.2 0.4 7e-07 28.6 0.0 2.4 3 1 0 3 3 3 1 Prolyl oligopeptidase family FSH1 PF03959.8 ESA09992.1 - 0.00016 21.1 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Chlorophyllase2 PF12740.2 ESA09992.1 - 0.0037 16.1 0.0 0.0054 15.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme LIP PF03583.9 ESA09992.1 - 0.0069 15.6 0.1 0.1 11.7 0.0 2.1 1 1 1 2 2 2 1 Secretory lipase Abhydrolase_2 PF02230.11 ESA09992.1 - 0.023 14.1 0.0 0.047 13.1 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.13 ESA09992.1 - 0.024 13.9 0.0 0.17 11.1 0.0 2.2 3 0 0 3 3 3 0 Dienelactone hydrolase family Peptidase_S10 PF00450.17 ESA09992.1 - 0.025 13.7 0.0 0.12 11.5 0.0 1.7 1 1 1 2 2 2 0 Serine carboxypeptidase Chlorophyllase PF07224.6 ESA09992.1 - 0.03 13.1 0.0 0.046 12.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Esterase_phd PF10503.4 ESA09992.1 - 0.079 12.1 0.0 6.7 5.8 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase UBA PF00627.26 ESA09993.1 - 7.3e-07 28.8 0.0 1.9e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain UBA_3 PF09288.5 ESA09993.1 - 0.0051 16.3 0.0 0.014 14.9 0.0 1.7 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain HBS1_N PF08938.5 ESA09993.1 - 0.012 15.7 1.0 0.021 14.9 0.0 1.9 2 0 0 2 2 2 0 HBS1 N-terminus Bromodomain PF00439.20 ESA09995.1 - 2.1e-22 78.8 0.9 1.5e-21 76.0 0.1 2.5 2 0 0 2 2 2 1 Bromodomain Myb_DNA-bind_6 PF13921.1 ESA09995.1 - 0.0021 18.1 0.1 0.0051 16.8 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PHD PF00628.24 ESA09996.1 - 3.3e-07 29.8 7.3 3.3e-07 29.8 5.1 2.0 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.1 ESA09996.1 - 0.053 13.6 2.5 0.15 12.2 1.7 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.1 ESA09996.1 - 1.4 8.3 10.6 7.9 5.8 7.3 2.3 1 1 0 1 1 1 0 PHD-finger Kelch_4 PF13418.1 ESA09997.1 - 1.3e-13 50.4 12.5 0.00066 19.3 0.2 4.8 4 2 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA09997.1 - 2.8e-11 43.2 6.7 6.5e-05 22.9 0.1 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA09997.1 - 6.5e-11 41.9 13.0 0.0033 17.5 0.8 4.6 3 1 1 4 4 4 4 Kelch motif Kelch_5 PF13854.1 ESA09997.1 - 3.1e-10 39.7 5.0 0.00025 20.9 0.4 3.9 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESA09997.1 - 2e-07 30.4 15.0 0.001 18.7 0.1 4.8 4 2 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA09997.1 - 0.00032 20.1 12.2 0.016 14.7 0.3 4.4 4 2 0 4 4 4 2 Kelch motif KH_4 PF13083.1 ESA09998.1 - 0.013 15.1 0.1 0.019 14.6 0.1 1.2 1 0 0 1 1 1 0 KH domain TB2_DP1_HVA22 PF03134.14 ESA09998.1 - 0.076 12.7 0.0 0.078 12.7 0.0 1.1 1 0 0 1 1 1 0 TB2/DP1, HVA22 family U3snoRNP10 PF12397.3 ESA10000.1 - 0.016 15.1 0.1 0.025 14.5 0.1 1.2 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 10 LRR_4 PF12799.2 ESA10003.1 - 0.016 14.7 3.4 0.18 11.4 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Cullin PF00888.17 ESA10005.1 - 5.4e-27 94.5 0.6 7.7e-27 94.0 0.2 1.4 1 1 0 1 1 1 1 Cullin family APC2 PF08672.6 ESA10005.1 - 7.1e-14 51.7 0.2 1.4e-13 50.8 0.2 1.5 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Destabilase PF05497.7 ESA10007.1 - 0.0072 16.4 0.4 0.0096 16.0 0.3 1.2 1 0 0 1 1 1 1 Destabilase GSH_synth_ATP PF03917.12 ESA10007.1 - 0.052 12.1 0.1 0.38 9.2 0.1 2.0 1 1 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain VRP1 PF03538.9 ESA10007.1 - 0.07 12.1 0.1 0.076 12.0 0.0 1.3 1 1 0 1 1 1 0 Salmonella virulence plasmid 28.1kDa A protein Chordopox_L2 PF05803.7 ESA10009.1 - 0.0038 16.8 0.1 0.0038 16.8 0.1 3.1 4 0 0 4 4 4 2 Chordopoxvirus L2 protein p450 PF00067.17 ESA10010.1 - 4.7e-24 84.7 0.1 8.2e-24 83.9 0.1 1.4 1 1 0 1 1 1 1 Cytochrome P450 Cupin_8 PF13621.1 ESA10010.1 - 0.014 14.9 0.2 0.52 9.7 0.0 2.5 1 1 2 3 3 3 0 Cupin-like domain SNAPc_SNAP43 PF09808.4 ESA10010.1 - 0.021 14.4 0.2 0.034 13.8 0.1 1.3 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 RRM_1 PF00076.17 ESA10011.1 - 1.2e-17 63.3 0.1 1.8e-17 62.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA10011.1 - 1.7e-15 56.7 0.0 3e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA10011.1 - 1.5e-09 37.5 0.0 2.4e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF837 PF05769.6 ESA10011.1 - 0.0039 16.7 0.2 0.0039 16.7 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF837) Proteasom_Rpn13 PF04683.8 ESA10012.1 - 0.044 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Proteasome complex subunit Rpn13 ubiquitin receptor LRR_8 PF13855.1 ESA10012.1 - 0.61 9.8 7.8 0.17 11.6 0.7 3.5 2 2 1 3 3 3 0 Leucine rich repeat Phosducin PF02114.11 ESA10013.1 - 0.012 14.3 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 0 Phosducin TMF_TATA_bd PF12325.3 ESA10013.1 - 0.35 10.5 2.9 1.3 8.7 1.6 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Transposase_21 PF02992.9 ESA10014.1 - 0.026 13.5 0.3 0.027 13.5 0.2 1.0 1 0 0 1 1 1 0 Transposase family tnp2 Acyltransferase PF01553.16 ESA10017.1 - 3.6e-21 74.9 0.0 9.1e-21 73.6 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase DUF3043 PF11241.3 ESA10018.1 - 0.74 9.3 6.1 0.58 9.7 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3043) DUF2976 PF11190.3 ESA10018.1 - 1.7 8.2 7.9 32 4.1 0.0 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF2976) NVEALA PF14055.1 ESA10018.1 - 4.4 7.0 7.8 4.6 7.0 0.1 3.4 4 0 0 4 4 4 0 NVEALA protein OppC_N PF12911.2 ESA10018.1 - 5.1 6.5 10.8 0.19 11.1 0.7 3.1 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C E1-E2_ATPase PF00122.15 ESA10018.1 - 5.2 6.0 8.1 6.1 5.8 1.2 2.7 1 1 0 2 2 2 0 E1-E2 ATPase Renin_r PF07850.9 ESA10018.1 - 5.5 7.4 10.8 3 8.2 0.1 2.9 3 1 0 3 3 3 0 Renin receptor-like protein Baculo_11_kDa PF06143.6 ESA10018.1 - 9.8 5.6 9.3 3.3 7.1 0.5 3.0 4 0 0 4 4 4 0 Baculovirus 11 kDa family BACK PF07707.10 ESA10020.1 - 2.2e-05 24.1 0.6 5e-05 23.0 0.4 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 ESA10020.1 - 0.0028 17.6 0.6 0.0071 16.3 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain RPM2 PF08579.6 ESA10020.1 - 0.06 13.4 1.1 0.56 10.3 0.1 2.4 1 1 0 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) Pkinase PF00069.20 ESA10021.1 - 1.6e-10 40.6 0.1 1.8e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10021.1 - 1.8e-09 37.0 0.1 2.1e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Hemocyanin_M PF00372.14 ESA10022.1 - 5.3e-13 48.9 0.6 9.3e-13 48.0 0.4 1.7 1 1 0 1 1 1 1 Hemocyanin, copper containing domain DUF2956 PF11169.3 ESA10022.1 - 0.23 11.4 3.8 0.37 10.7 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) MIF4G PF02854.14 ESA10025.1 - 2.5e-46 157.7 10.1 2.5e-46 157.7 7.0 1.3 2 0 0 2 2 2 1 MIF4G domain Ras_bdg_2 PF14847.1 ESA10026.1 - 0.013 15.4 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 Ras-binding domain of Byr2 DEAD PF00270.24 ESA10029.1 - 3e-16 59.3 0.0 8.9e-16 57.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA10029.1 - 1.4e-12 47.3 0.0 3.8e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA10029.1 - 2.7e-08 33.8 0.0 9.5e-08 32.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T4SS-DNA_transf PF02534.9 ESA10029.1 - 0.011 14.3 0.0 0.02 13.4 0.0 1.4 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer IstB_IS21 PF01695.12 ESA10029.1 - 0.022 14.1 0.0 0.077 12.4 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein PhoH PF02562.11 ESA10029.1 - 0.051 12.7 0.0 2.2 7.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein SH3_9 PF14604.1 ESA10030.1 - 2.2e-13 49.5 0.0 3.4e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 ESA10030.1 - 8e-12 44.3 0.3 1.3e-11 43.6 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA10030.1 - 2.1e-10 39.9 0.0 3.4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.3 ESA10030.1 - 0.14 11.5 0.1 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) CBFD_NFYB_HMF PF00808.18 ESA10031.1 - 1.2e-11 44.5 0.4 1.4e-11 44.2 0.3 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.1 ESA10031.1 - 3.2e-09 36.6 2.8 1e-08 35.1 1.9 1.7 1 1 0 1 1 1 1 Centromere kinetochore component W AAA_32 PF13654.1 ESA10031.1 - 0.02 13.5 0.2 0.021 13.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain Histone PF00125.19 ESA10031.1 - 0.053 13.6 0.2 0.059 13.4 0.1 1.2 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 RNA_pol_I_A49 PF06870.7 ESA10031.1 - 0.063 11.8 0.5 0.068 11.7 0.3 1.0 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor Methyltransf_31 PF13847.1 ESA10032.1 - 0.67 9.5 5.9 0.82 9.2 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain DUF2681 PF10883.3 ESA10033.1 - 0.05 13.7 0.7 0.054 13.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DivIC PF04977.10 ESA10033.1 - 0.12 11.8 1.1 0.15 11.5 0.8 1.2 1 0 0 1 1 1 0 Septum formation initiator DUF2740 PF10872.3 ESA10033.1 - 3.9 7.2 5.7 5 6.8 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2740) DUF3651 PF12371.3 ESA10036.1 - 0.075 13.0 0.0 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3651) NOA36 PF06524.7 ESA10037.1 - 1.7 7.7 5.5 2 7.6 3.8 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.1 ESA10040.1 - 0.031 14.4 0.2 0.043 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Methyltransf_11 PF08241.7 ESA10041.1 - 5.1e-14 52.5 0.0 1.2e-13 51.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA10041.1 - 1.3e-12 47.5 0.1 1.4e-11 44.1 0.0 2.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA10041.1 - 1e-11 45.0 0.0 2.2e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA10041.1 - 1.1e-09 38.1 0.0 1.6e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA10041.1 - 1.5e-06 27.6 0.0 2.9e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA10041.1 - 2.3e-06 28.1 0.0 9.3e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA10041.1 - 2.7e-06 27.7 0.0 6.9e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA10041.1 - 5.3e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA10041.1 - 0.0011 18.1 0.0 0.0054 15.8 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA10041.1 - 0.0026 16.8 0.0 0.0045 16.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 ESA10041.1 - 0.0034 17.3 0.0 0.041 13.8 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.11 ESA10041.1 - 0.021 13.1 0.0 0.35 9.1 0.0 2.1 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.13 ESA10041.1 - 0.042 13.0 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase CMAS PF02353.15 ESA10041.1 - 0.053 12.6 0.1 0.14 11.1 0.1 1.7 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase HTH_30 PF13556.1 ESA10042.1 - 1.4e-14 53.3 0.1 2.8e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain DUF4362 PF14275.1 ESA10042.1 - 0.00084 19.3 0.2 0.99 9.4 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4362) HTH_28 PF13518.1 ESA10042.1 - 0.011 15.7 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain SAM_2 PF07647.12 ESA10042.1 - 0.061 13.1 0.0 0.29 11.0 0.0 2.1 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) HTH_23 PF13384.1 ESA10042.1 - 0.066 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_8 PF02954.14 ESA10042.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family PyrI_C PF02748.10 ESA10043.1 - 0.15 11.5 0.1 0.15 11.5 0.0 2.9 3 1 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Peptidase_M17 PF00883.16 ESA10044.1 - 3e-09 36.2 0.0 0.00015 20.7 0.0 2.0 1 1 1 2 2 2 2 Cytosol aminopeptidase family, catalytic domain N-Term_TEN PF11474.3 ESA10045.1 - 0.039 13.3 0.2 0.051 12.9 0.1 1.4 1 1 0 1 1 1 0 Telomerase reverse transcriptase TEN domain SH3_1 PF00018.23 ESA10048.1 - 6.2e-14 51.1 0.2 7.7e-14 50.8 0.1 1.1 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA10048.1 - 1.2e-12 47.2 0.0 1.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA10048.1 - 7.4e-10 38.1 0.0 8.2e-10 38.0 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain TPR_17 PF13431.1 ESA10048.1 - 0.2 11.9 1.0 0.29 11.4 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Ifi-6-16 PF06140.8 ESA10050.1 - 2e-05 24.2 8.1 3.5e-05 23.5 5.6 1.4 1 0 0 1 1 1 1 Interferon-induced 6-16 family Baculo_11_kDa PF06143.6 ESA10050.1 - 0.00093 18.5 0.1 0.00093 18.5 0.0 1.9 2 0 0 2 2 2 1 Baculovirus 11 kDa family TPPK_C PF12555.3 ESA10050.1 - 0.56 9.9 2.7 0.52 10.0 0.7 1.8 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal DuoxA PF10204.4 ESA10050.1 - 0.61 9.0 3.6 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 Dual oxidase maturation factor OppC_N PF12911.2 ESA10050.1 - 1 8.7 9.0 1.1 8.6 1.5 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Glucan_synthase PF02364.10 ESA10051.1 - 5.5e-272 904.4 28.0 1.4e-137 459.8 5.5 5.9 3 2 2 5 5 5 3 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 ESA10051.1 - 3.2e-36 123.8 1.3 1.4e-35 121.7 0.9 2.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Ifi-6-16 PF06140.8 ESA10053.1 - 0.029 14.1 0.4 0.034 13.9 0.3 1.2 1 0 0 1 1 1 0 Interferon-induced 6-16 family HTH_Tnp_Tc5 PF03221.11 ESA10054.1 - 7.6e-08 32.0 0.1 7.1e-07 28.9 0.0 2.2 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA10054.1 - 3.9e-05 22.9 0.9 0.00013 21.2 0.6 2.0 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.14 ESA10054.1 - 0.0014 17.7 0.8 0.0024 17.0 0.0 1.8 3 0 0 3 3 3 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.13 ESA10054.1 - 0.024 14.6 0.1 0.13 12.3 0.0 2.2 3 0 0 3 3 3 0 Transposase HTH_38 PF13936.1 ESA10054.1 - 0.035 13.6 0.0 1.3 8.6 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain MarR PF01047.17 ESA10054.1 - 0.075 12.7 0.1 0.68 9.6 0.1 2.4 1 1 0 1 1 1 0 MarR family Ribosomal_S6e PF01092.14 ESA10056.1 - 0.09 12.4 0.1 0.23 11.1 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein S6e NAD_binding_10 PF13460.1 ESA10057.1 - 2.8e-29 102.4 0.0 3.4e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESA10057.1 - 1.2e-08 34.5 0.0 1.7e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 ESA10057.1 - 1.8e-06 27.6 0.0 2.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA10057.1 - 0.0048 15.6 0.1 0.0068 15.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Saccharop_dh PF03435.13 ESA10057.1 - 0.012 14.5 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase XPA_N PF01286.13 ESA10058.1 - 0.12 12.1 0.2 0.12 12.1 0.1 3.1 3 0 0 3 3 3 0 XPA protein N-terminal Phage_coat PF09063.5 ESA10060.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.5 1 1 0 1 1 1 0 Phage PP7 coat protein Exo_endo_phos PF03372.18 ESA10061.1 - 1.3e-14 54.7 0.0 1.6e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2577 PF10844.3 ESA10061.1 - 0.017 15.1 0.1 4 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2577) TraL PF07178.6 ESA10061.1 - 0.12 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 TraL protein Tubulin PF00091.20 ESA10062.1 - 6e-71 238.7 0.0 8.8e-71 238.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESA10062.1 - 8.8e-48 161.5 0.1 1.4e-47 160.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESA10062.1 - 0.00038 20.4 0.0 0.00075 19.5 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESA10062.1 - 0.032 13.6 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Pkinase_Tyr PF07714.12 ESA10063.1 - 2.4e-13 49.7 0.1 2.7e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10063.1 - 2.1e-11 43.5 0.2 2.5e-11 43.2 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain SufE PF02657.10 ESA10063.1 - 0.0067 16.0 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 Fe-S metabolism associated domain PepX_N PF09168.5 ESA10063.1 - 0.017 15.3 0.4 0.02 15.1 0.3 1.2 1 0 0 1 1 1 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal Sel1 PF08238.7 ESA10064.1 - 2.8e-12 46.8 10.2 2.4e-08 34.3 0.3 3.4 4 1 1 5 5 5 2 Sel1 repeat TPR_6 PF13174.1 ESA10064.1 - 2.5e-05 24.4 3.4 0.17 12.4 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10064.1 - 0.0011 19.5 1.6 0.03 15.0 0.1 3.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA10064.1 - 0.01 16.1 0.5 6.5 7.1 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C25_C PF03785.9 ESA10064.1 - 0.043 13.6 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family C25, C terminal ig-like domain ASFV_360 PF01671.11 ESA10064.1 - 0.17 11.2 2.0 0.38 10.1 0.2 2.0 2 0 0 2 2 2 0 African swine fever virus multigene family 360 protein TPR_11 PF13414.1 ESA10064.1 - 2 8.1 7.5 4.4 7.0 3.0 2.9 2 1 0 2 2 2 0 TPR repeat Swi5 PF07061.6 ESA10065.1 - 0.014 15.1 3.4 0.017 14.9 2.4 1.1 1 0 0 1 1 1 0 Swi5 Atx10homo_assoc PF09759.4 ESA10065.1 - 0.034 13.8 1.3 0.041 13.6 0.9 1.1 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain MitMem_reg PF13012.1 ESA10065.1 - 0.12 12.4 4.4 0.13 12.3 3.0 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function FMN_dh PF01070.13 ESA10067.1 - 7.4e-125 416.4 0.0 9.5e-125 416.1 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 ESA10067.1 - 2.5e-25 88.0 0.0 6.2e-25 86.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 ESA10067.1 - 5.3e-10 38.7 0.0 9.6e-10 37.8 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 ESA10067.1 - 3.3e-05 22.9 0.3 8.8e-05 21.5 0.2 1.6 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 ESA10067.1 - 0.012 14.7 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase ThiG PF05690.9 ESA10067.1 - 0.019 14.0 0.0 4.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 ESA10067.1 - 0.047 12.9 0.1 0.21 10.8 0.0 1.9 1 1 0 1 1 1 0 Histidine biosynthesis protein Ribosomal_L23 PF00276.15 ESA10068.1 - 3.1e-14 52.6 0.8 7.3e-14 51.4 0.1 1.8 1 1 1 2 2 2 1 Ribosomal protein L23 Uma2 PF05685.7 ESA10069.1 - 6.8e-07 28.7 0.0 1.2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Putative restriction endonuclease Methyltransf_16 PF10294.4 ESA10069.1 - 0.11 11.9 0.4 0.23 10.9 0.3 1.4 1 0 0 1 1 1 0 Putative methyltransferase DUF2304 PF10066.4 ESA10070.1 - 0.33 10.7 7.9 0.64 9.8 5.5 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) Myosin_tail_1 PF01576.14 ESA10071.1 - 0.00021 19.2 7.2 0.0003 18.6 5.0 1.3 1 0 0 1 1 1 1 Myosin tail DUF972 PF06156.8 ESA10071.1 - 0.00023 21.4 9.0 0.014 15.6 0.8 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF972) FlxA PF14282.1 ESA10071.1 - 0.00052 19.9 8.6 0.00077 19.3 6.0 1.3 1 0 0 1 1 1 1 FlxA-like protein Baculo_PEP_C PF04513.7 ESA10071.1 - 0.00056 19.7 0.3 0.00069 19.4 0.2 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.15 ESA10071.1 - 0.00065 19.4 12.0 0.11 12.2 0.2 2.1 2 0 0 2 2 2 2 Prefoldin subunit priB_priC PF07445.7 ESA10071.1 - 0.00094 18.6 2.3 0.0012 18.2 1.6 1.2 1 0 0 1 1 1 1 Primosomal replication protein priB and priC CCDC155 PF14662.1 ESA10071.1 - 0.0015 18.1 10.0 0.002 17.7 7.0 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 DivIC PF04977.10 ESA10071.1 - 0.0015 17.9 13.4 0.098 12.1 1.7 2.5 1 1 2 3 3 3 2 Septum formation initiator ADIP PF11559.3 ESA10071.1 - 0.0025 17.7 14.7 0.13 12.1 4.5 2.1 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding EzrA PF06160.7 ESA10071.1 - 0.0027 15.9 4.9 0.0032 15.7 3.4 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Snapin_Pallidin PF14712.1 ESA10071.1 - 0.0037 17.5 9.6 0.019 15.2 0.7 2.2 1 1 0 2 2 2 1 Snapin/Pallidin UPF0184 PF03670.8 ESA10071.1 - 0.0038 17.3 4.8 0.057 13.5 0.7 2.3 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0184) DUF3573 PF12097.3 ESA10071.1 - 0.0044 15.6 3.5 0.0045 15.6 2.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3573) DUF3552 PF12072.3 ESA10071.1 - 0.0046 16.2 10.6 0.0056 15.9 7.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) THOC7 PF05615.8 ESA10071.1 - 0.0046 17.2 6.3 0.0046 17.2 4.3 2.0 1 1 0 2 2 2 1 Tho complex subunit 7 TSC22 PF01166.13 ESA10071.1 - 0.0055 16.6 9.7 0.38 10.7 1.2 3.1 2 1 1 3 3 3 1 TSC-22/dip/bun family SlyX PF04102.7 ESA10071.1 - 0.012 15.9 3.9 0.96 9.8 0.6 2.3 2 0 0 2 2 2 0 SlyX Laminin_I PF06008.9 ESA10071.1 - 0.012 14.8 6.3 0.014 14.7 4.4 1.1 1 0 0 1 1 1 0 Laminin Domain I Hemagglutinin PF00509.13 ESA10071.1 - 0.015 13.4 0.8 0.018 13.2 0.6 1.1 1 0 0 1 1 1 0 Haemagglutinin DUF535 PF04393.8 ESA10071.1 - 0.016 14.1 1.0 0.016 14.1 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF535) AKNA PF12443.3 ESA10071.1 - 0.017 15.0 9.7 0.045 13.7 2.0 2.2 1 1 1 2 2 2 0 AT-hook-containing transcription factor GOLGA2L5 PF15070.1 ESA10071.1 - 0.021 13.3 8.4 0.024 13.1 5.8 1.0 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 CENP-H PF05837.7 ESA10071.1 - 0.021 15.0 8.2 0.021 14.9 5.1 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) GAS PF13851.1 ESA10071.1 - 0.021 14.0 12.1 0.028 13.5 8.4 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Transposase_22 PF02994.9 ESA10071.1 - 0.022 13.2 6.2 0.025 13.0 4.3 1.1 1 0 0 1 1 1 0 L1 transposable element DUF2968 PF11180.3 ESA10071.1 - 0.024 14.0 6.4 0.029 13.7 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) RNA_pol_Rpb4 PF03874.11 ESA10071.1 - 0.024 14.6 4.0 0.03 14.3 2.8 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb4 Vir_act_alpha_C PF10400.4 ESA10071.1 - 0.025 14.9 3.5 2 8.8 0.0 2.2 1 1 1 2 2 2 0 Virulence activator alpha C-term Jnk-SapK_ap_N PF09744.4 ESA10071.1 - 0.027 14.4 12.7 0.036 14.0 3.2 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliJ PF02050.11 ESA10071.1 - 0.028 14.4 8.9 0.17 11.9 0.6 2.1 1 1 1 2 2 2 0 Flagellar FliJ protein DASH_Dam1 PF08653.5 ESA10071.1 - 0.029 14.1 1.4 2.5 7.9 0.1 2.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 UPF0449 PF15136.1 ESA10071.1 - 0.029 14.5 10.8 0.073 13.2 0.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Nnf1 PF03980.9 ESA10071.1 - 0.03 14.3 5.7 0.93 9.5 0.5 2.3 2 0 0 2 2 2 0 Nnf1 CASP_C PF08172.7 ESA10071.1 - 0.047 12.7 12.2 0.055 12.4 2.9 2.1 1 1 1 2 2 2 0 CASP C terminal AAA_13 PF13166.1 ESA10071.1 - 0.047 12.1 5.6 0.057 11.8 3.9 1.1 1 0 0 1 1 1 0 AAA domain NPV_P10 PF05531.7 ESA10071.1 - 0.051 13.8 2.4 1.4 9.2 0.2 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.16 ESA10071.1 - 0.053 13.4 15.5 0.073 13.0 0.6 2.5 2 1 0 2 2 2 0 bZIP transcription factor CENP-F_leu_zip PF10473.4 ESA10071.1 - 0.07 12.9 14.5 0.16 11.8 9.9 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.14 ESA10071.1 - 0.076 12.5 10.8 0.091 12.2 7.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4140 PF13600.1 ESA10071.1 - 0.077 13.4 5.2 3.9 7.9 1.1 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Tweety PF04906.8 ESA10071.1 - 0.083 11.2 1.1 0.091 11.1 0.8 1.1 1 0 0 1 1 1 0 Tweety Med9 PF07544.8 ESA10071.1 - 0.085 12.6 7.0 0.23 11.2 4.8 1.8 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Phasin PF05597.6 ESA10071.1 - 0.086 12.5 6.0 0.13 12.0 4.2 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DivIVA PF05103.8 ESA10071.1 - 0.087 12.8 10.6 0.61 10.1 1.8 2.2 1 1 1 2 2 2 0 DivIVA protein Mod_r PF07200.8 ESA10071.1 - 0.093 12.6 9.9 0.2 11.5 6.7 1.6 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Prefoldin PF02996.12 ESA10071.1 - 0.096 12.3 6.7 0.69 9.5 0.2 2.2 2 0 0 2 2 2 0 Prefoldin subunit TBPIP PF07106.8 ESA10071.1 - 0.1 12.1 12.3 0.33 10.4 0.7 1.8 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) V_ATPase_I PF01496.14 ESA10071.1 - 0.11 10.3 7.6 0.12 10.1 5.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 ESA10071.1 - 0.11 12.0 14.8 1.9 8.0 9.9 2.0 1 1 0 1 1 1 0 IncA protein DRMBL PF07522.9 ESA10071.1 - 0.11 12.5 0.2 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Allexi_40kDa PF05549.6 ESA10071.1 - 0.12 11.6 2.6 0.14 11.4 1.8 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein HSBP1 PF06825.7 ESA10071.1 - 0.12 11.9 2.9 2.9 7.5 0.4 2.2 1 1 1 2 2 2 0 Heat shock factor binding protein 1 MtrB PF05440.7 ESA10071.1 - 0.14 12.2 0.7 2.2 8.4 0.2 2.0 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B APG6 PF04111.7 ESA10071.1 - 0.14 11.2 12.4 0.17 10.8 8.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Syntaxin-6_N PF09177.6 ESA10071.1 - 0.14 12.5 7.2 0.21 12.0 3.9 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal bZIP_2 PF07716.10 ESA10071.1 - 0.15 11.9 16.8 1.5 8.6 1.3 2.6 2 1 0 2 2 2 0 Basic region leucine zipper COG5 PF10392.4 ESA10071.1 - 0.15 11.9 3.4 0.19 11.7 2.4 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 BLOC1_2 PF10046.4 ESA10071.1 - 0.16 12.1 9.5 0.92 9.6 5.3 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Intein_splicing PF14890.1 ESA10071.1 - 0.17 10.7 1.7 0.21 10.4 1.2 1.0 1 0 0 1 1 1 0 Intein splicing domain Lipoprotein_20 PF13942.1 ESA10071.1 - 0.18 11.2 10.7 0.15 11.5 5.2 1.9 1 1 1 2 2 2 0 YfhG lipoprotein DUF2802 PF10975.3 ESA10071.1 - 0.19 11.5 5.7 2.2 8.1 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2802) Viral_P18 PF04521.8 ESA10071.1 - 0.2 11.1 7.4 0.6 9.5 0.1 2.2 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein FlaC_arch PF05377.6 ESA10071.1 - 0.2 11.5 4.6 3.9 7.4 0.2 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3584 PF12128.3 ESA10071.1 - 0.21 8.8 8.3 0.25 8.6 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF904 PF06005.7 ESA10071.1 - 0.22 11.8 14.9 4.6 7.6 9.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) G6PD_N PF00479.17 ESA10071.1 - 0.22 11.7 3.0 0.5 10.5 2.1 1.6 1 1 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain K-box PF01486.12 ESA10071.1 - 0.23 11.2 11.6 0.68 9.7 2.7 2.7 1 1 0 2 2 2 0 K-box region Laminin_II PF06009.7 ESA10071.1 - 0.23 11.2 6.7 0.47 10.2 4.7 1.6 1 1 0 1 1 1 0 Laminin Domain II Adeno_PIX PF03955.9 ESA10071.1 - 0.24 11.9 1.5 0.32 11.5 1.0 1.2 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) STAT_alpha PF01017.15 ESA10071.1 - 0.25 11.0 9.2 0.08 12.6 1.2 2.1 1 1 1 2 2 2 0 STAT protein, all-alpha domain Seryl_tRNA_N PF02403.17 ESA10071.1 - 0.26 11.3 11.1 0.63 10.0 7.7 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF848 PF05852.6 ESA10071.1 - 0.28 11.0 5.8 0.34 10.7 4.0 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF342 PF03961.8 ESA10071.1 - 0.28 9.5 7.8 0.36 9.1 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF948 PF06103.6 ESA10071.1 - 0.28 11.0 3.0 0.72 9.7 2.1 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF2730 PF10805.3 ESA10071.1 - 0.38 10.4 5.3 0.85 9.3 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) FliD_N PF02465.13 ESA10071.1 - 0.39 11.0 6.4 7.4 7.0 1.6 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus HlyD PF00529.15 ESA10071.1 - 0.42 9.8 4.6 0.47 9.7 3.2 1.0 1 0 0 1 1 1 0 HlyD family secretion protein DUF724 PF05266.9 ESA10071.1 - 0.43 10.1 11.5 1.1 8.8 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.7 ESA10071.1 - 0.44 10.3 4.9 4.6 7.0 3.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) P4Ha_N PF08336.6 ESA10071.1 - 0.44 10.3 7.5 2.9 7.7 1.0 2.1 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2040 PF09745.4 ESA10071.1 - 0.44 10.3 10.6 0.58 9.9 7.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 55 (DUF2040) Gp-FAR-1 PF05823.7 ESA10071.1 - 0.46 10.4 7.0 1.5 8.7 1.9 2.1 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Tropomyosin_1 PF12718.2 ESA10071.1 - 0.49 10.2 13.2 0.18 11.6 1.1 1.9 1 1 0 1 1 1 0 Tropomyosin like Cep57_CLD_2 PF14197.1 ESA10071.1 - 0.51 10.3 12.7 2.7 7.9 1.6 2.6 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Mnd1 PF03962.10 ESA10071.1 - 0.55 9.8 10.8 1.2 8.7 7.5 1.5 1 1 0 1 1 1 0 Mnd1 family DUF3393 PF11873.3 ESA10071.1 - 0.56 9.6 4.5 0.33 10.4 1.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3393) HemX PF04375.9 ESA10071.1 - 0.58 8.6 5.8 0.67 8.4 4.0 1.1 1 0 0 1 1 1 0 HemX Atg14 PF10186.4 ESA10071.1 - 0.61 8.9 9.3 0.78 8.6 6.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DASH_Dad2 PF08654.5 ESA10071.1 - 0.61 10.1 8.6 2 8.4 1.7 2.2 1 1 0 2 2 2 0 DASH complex subunit Dad2 DUF3450 PF11932.3 ESA10071.1 - 0.61 9.3 9.0 2.3 7.4 6.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) CorA PF01544.13 ESA10071.1 - 0.65 8.9 4.6 2.3 7.1 0.2 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Microtub_assoc PF07989.6 ESA10071.1 - 0.65 9.8 8.2 0.79 9.5 1.0 2.3 1 1 1 2 2 2 0 Microtubule associated YPEB PF14620.1 ESA10071.1 - 0.66 8.9 6.0 0.79 8.6 4.2 1.1 1 0 0 1 1 1 0 YpeB sporulation DUF4200 PF13863.1 ESA10071.1 - 0.69 9.8 14.6 1.6 8.7 4.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) FemAB PF02388.11 ESA10071.1 - 0.72 8.4 6.8 0.85 8.2 4.7 1.2 1 0 0 1 1 1 0 FemAB family TMF_DNA_bd PF12329.3 ESA10071.1 - 0.72 9.6 15.4 0.32 10.8 1.3 2.2 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.7 ESA10071.1 - 0.77 9.5 15.0 3.3 7.4 10.4 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein bZIP_Maf PF03131.12 ESA10071.1 - 0.79 10.0 12.4 3.3 8.0 0.6 2.2 1 1 1 2 2 2 0 bZIP Maf transcription factor Ax_dynein_light PF10211.4 ESA10071.1 - 0.83 9.4 14.5 1.8 8.3 1.2 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain eIF-4B PF06273.6 ESA10071.1 - 0.86 8.2 5.5 0.96 8.1 3.8 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Prominin PF05478.6 ESA10071.1 - 0.87 7.0 6.2 1.4 6.3 2.9 1.7 1 1 1 2 2 2 0 Prominin DUF4407 PF14362.1 ESA10071.1 - 0.9 8.4 6.2 1.7 7.5 4.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spc24 PF08286.6 ESA10071.1 - 0.91 9.2 12.2 1.1 9.0 1.7 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlgN PF05130.7 ESA10071.1 - 0.94 9.7 8.7 0.91 9.7 1.5 2.0 1 1 1 2 2 2 0 FlgN protein Spc42p PF11544.3 ESA10071.1 - 1.1 9.2 10.4 5.8 6.9 0.7 2.2 1 1 1 2 2 2 0 Spindle pole body component Spc42p Nup54 PF13874.1 ESA10071.1 - 1.1 8.9 8.2 4 7.1 5.7 1.8 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Fib_alpha PF08702.5 ESA10071.1 - 1.2 9.2 9.0 6.2 6.9 6.2 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family HSP70 PF00012.15 ESA10071.1 - 1.3 6.8 5.7 1.6 6.5 3.9 1.0 1 0 0 1 1 1 0 Hsp70 protein YscO PF07321.7 ESA10071.1 - 1.4 8.7 12.5 4.3 7.1 8.7 1.7 1 1 0 1 1 1 0 Type III secretion protein YscO ORF6C PF10552.4 ESA10071.1 - 1.4 8.6 8.9 4.7 6.9 0.9 2.2 1 1 1 2 2 2 0 ORF6C domain DUF3373 PF11853.3 ESA10071.1 - 1.5 7.2 10.2 5.5 5.4 7.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) Pox_A_type_inc PF04508.7 ESA10071.1 - 1.9 8.4 8.9 1.3 8.9 1.7 3.3 4 0 0 4 4 2 0 Viral A-type inclusion protein repeat EMP24_GP25L PF01105.19 ESA10071.1 - 2.4 7.8 10.3 7.7 6.1 1.0 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF2205 PF10224.4 ESA10071.1 - 2.4 7.8 10.9 4.7 6.8 3.5 2.1 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) PEP-utilisers_N PF05524.8 ESA10071.1 - 2.5 7.9 5.4 2.5 7.9 0.8 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DUF4398 PF14346.1 ESA10071.1 - 2.6 8.1 7.0 0.75 9.8 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) Tup_N PF08581.5 ESA10071.1 - 2.6 8.3 10.7 10 6.4 2.7 2.2 1 1 1 2 2 2 0 Tup N-terminal DUF16 PF01519.11 ESA10071.1 - 3 8.1 10.3 1.1 9.5 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 FadA PF09403.5 ESA10071.1 - 3.2 7.7 10.3 5.4 7.0 7.1 1.3 1 1 0 1 1 1 0 Adhesion protein FadA DUF4164 PF13747.1 ESA10071.1 - 3.3 7.9 10.9 2.2 8.4 2.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Scm3 PF10384.4 ESA10071.1 - 3.5 7.1 5.5 2 7.9 1.2 2.5 1 1 1 2 2 2 0 Centromere protein Scm3 Streptin-Immun PF11083.3 ESA10071.1 - 4.3 7.4 9.3 87 3.1 6.4 2.0 1 1 0 1 1 1 0 Lantibiotic streptin immunity protein Occludin_ELL PF07303.8 ESA10071.1 - 4.9 7.9 11.0 5.6 7.7 2.8 2.1 1 1 1 2 2 2 0 Occludin homology domain Synaptobrevin PF00957.16 ESA10071.1 - 4.9 6.8 6.7 16 5.1 0.4 2.4 1 1 1 2 2 2 0 Synaptobrevin HALZ PF02183.13 ESA10071.1 - 5.3 6.8 10.8 4.7 7.0 0.7 3.3 2 2 1 3 3 3 0 Homeobox associated leucine zipper AAA_23 PF13476.1 ESA10071.1 - 5.5 7.2 11.1 6.9 6.9 7.7 1.1 1 0 0 1 1 1 0 AAA domain XhlA PF10779.4 ESA10071.1 - 5.7 6.9 7.1 10 6.1 0.4 2.2 2 0 0 2 2 2 0 Haemolysin XhlA DUF4446 PF14584.1 ESA10071.1 - 6.9 6.4 8.7 8.8 6.1 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF3847 PF12958.2 ESA10071.1 - 7.5 6.3 12.5 6.4 6.6 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) PspB PF06667.7 ESA10071.1 - 8.4 6.4 8.0 8 6.4 0.7 2.4 1 1 1 2 2 2 0 Phage shock protein B Cys_Met_Meta_PP PF01053.15 ESA10073.1 - 6.6e-06 24.6 0.0 6.8e-06 24.6 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GATA PF00320.22 ESA10074.1 - 1e-15 56.7 5.7 2.1e-15 55.7 3.9 1.5 1 0 0 1 1 1 1 GATA zinc finger NinG PF05766.7 ESA10074.1 - 9.8e-05 22.1 4.6 0.00016 21.4 3.2 1.3 1 0 0 1 1 1 1 Bacteriophage Lambda NinG protein PRP38_assoc PF12871.2 ESA10074.1 - 0.0008 19.8 4.8 0.0016 18.9 3.3 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3824 PF12868.2 ESA10074.1 - 0.14 13.1 8.5 0.23 12.3 5.9 1.4 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PAT1 PF09770.4 ESA10074.1 - 0.14 10.3 11.7 0.17 10.0 8.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DZR PF12773.2 ESA10074.1 - 0.22 11.3 2.3 0.54 10.1 1.6 1.7 1 1 0 1 1 1 0 Double zinc ribbon Spc7_N PF15402.1 ESA10074.1 - 0.5 8.3 9.6 0.83 7.5 6.6 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 CemA PF03040.9 ESA10075.1 - 0.054 13.0 1.3 0.059 12.9 0.9 1.0 1 0 0 1 1 1 0 CemA family PP2C_C PF07830.8 ESA10075.1 - 0.11 12.6 0.6 0.16 12.1 0.4 1.3 1 0 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain Vpu PF00558.14 ESA10075.1 - 0.93 9.1 4.5 1.5 8.4 3.1 1.4 1 0 0 1 1 1 0 Vpu protein SR-25 PF10500.4 ESA10078.1 - 5.7 6.3 13.7 7 6.0 9.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PIF1 PF05970.9 ESA10079.1 - 0.0022 17.0 0.0 0.0036 16.3 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase Sel1 PF08238.7 ESA10080.1 - 2.9e-13 49.9 2.7 1.5e-12 47.7 0.3 2.2 2 1 0 2 2 2 1 Sel1 repeat DUF4445 PF14574.1 ESA10081.1 - 0.13 10.4 0.5 0.13 10.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4445) Spore_YhcN_YlaJ PF09580.5 ESA10081.1 - 0.45 10.6 6.8 1.5 8.8 0.1 1.9 1 1 1 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Pkinase_Tyr PF07714.12 ESA10082.1 - 3.4e-23 82.0 0.0 2.1e-22 79.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10082.1 - 2e-20 73.0 0.0 2.6e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain 4HBT PF03061.17 ESA10082.1 - 0.035 14.2 0.5 1.8 8.7 0.0 2.4 2 0 0 2 2 2 0 Thioesterase superfamily Histone PF00125.19 ESA10084.1 - 3.6e-31 107.1 0.4 5.5e-31 106.5 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA10084.1 - 2e-05 24.6 0.0 3.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA10084.1 - 0.01 15.9 0.1 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 ESA10084.1 - 0.017 14.4 0.9 0.025 13.8 0.6 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 ESA10084.1 - 0.051 13.3 0.1 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.19 ESA10085.1 - 2.3e-12 46.8 0.0 2.8e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA10085.1 - 0.00088 19.2 0.2 0.0019 18.2 0.1 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.1 ESA10085.1 - 0.0015 18.6 0.0 0.0019 18.3 0.0 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 ESA10085.1 - 0.0034 17.2 0.2 0.0048 16.8 0.1 1.5 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T PF15511.1 ESA10085.1 - 0.041 13.1 0.0 0.041 13.1 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Histone PF00125.19 ESA10086.1 - 2.5e-31 107.6 0.5 3.8e-31 107.0 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA10086.1 - 1.2e-05 25.3 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA10086.1 - 0.0024 17.8 0.1 0.0049 16.9 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 ESA10086.1 - 0.0099 15.5 0.1 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.19 ESA10087.1 - 1.1e-12 47.8 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA10087.1 - 0.00065 19.8 0.0 0.00081 19.5 0.0 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA10087.1 - 0.00098 19.1 0.2 0.0021 18.0 0.1 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.12 ESA10087.1 - 0.0023 17.8 0.2 0.0033 17.3 0.1 1.5 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T PF15511.1 ESA10087.1 - 0.015 14.5 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T BK_channel_a PF03493.13 ESA10089.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Mob_Pre PF01076.14 ESA10089.1 - 0.085 12.4 0.3 4.1 6.9 0.0 2.1 1 1 0 2 2 2 0 Plasmid recombination enzyme ThiI PF02568.9 ESA10089.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Methyltransf_31 PF13847.1 ESA10091.1 - 7.6e-18 64.5 0.3 8.9e-18 64.3 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA10091.1 - 4.1e-16 59.1 0.1 6.1e-16 58.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA10091.1 - 4.6e-12 46.2 0.0 7.6e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA10091.1 - 1.2e-11 44.9 0.1 2.4e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA10091.1 - 6.6e-10 39.5 0.1 1.2e-09 38.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA10091.1 - 1.6e-09 37.9 0.0 3.2e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA10091.1 - 3.3e-07 29.6 0.1 5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 ESA10091.1 - 1.9e-06 27.3 0.1 2.7e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESA10091.1 - 3.2e-05 23.9 0.0 5.4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 ESA10091.1 - 3.5e-05 22.9 0.0 6.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.1 ESA10091.1 - 0.00019 21.1 0.1 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESA10091.1 - 0.00022 20.4 0.0 0.00031 19.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.6 ESA10091.1 - 0.0045 16.4 0.0 0.0069 15.8 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) DREV PF05219.7 ESA10091.1 - 0.05 12.4 0.1 0.077 11.8 0.0 1.4 1 1 0 1 1 1 0 DREV methyltransferase TLD PF07534.11 ESA10092.1 - 3.2e-11 43.3 1.8 6.2e-11 42.4 1.3 1.5 1 0 0 1 1 1 1 TLD MoCo_carrier PF12694.2 ESA10094.1 - 2.7e-45 153.3 0.2 2.1e-44 150.5 0.1 1.9 1 1 0 1 1 1 1 Putative molybdenum carrier Actin PF00022.14 ESA10096.1 - 2.3e-141 470.7 0.0 2.7e-141 470.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESA10096.1 - 2e-07 29.9 0.0 1.6e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein DUF367 PF04034.8 ESA10096.1 - 0.16 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF367) DAO PF01266.19 ESA10098.1 - 5.4e-24 84.7 0.0 1.2e-23 83.5 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA10098.1 - 0.0022 17.9 0.1 0.0056 16.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 ESA10098.1 - 0.005 15.9 0.1 0.0075 15.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 ESA10098.1 - 0.038 14.3 0.6 0.11 12.9 0.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.9 ESA10098.1 - 0.047 13.0 0.3 0.074 12.4 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.9 ESA10098.1 - 0.078 12.8 0.0 0.15 11.9 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 ESA10098.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain 3HCDH_N PF02737.13 ESA10098.1 - 0.12 11.9 0.2 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 ESA10098.1 - 0.13 11.6 0.2 0.25 10.7 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NUC153 PF08159.7 ESA10099.1 - 8.2e-10 38.0 14.6 1e-09 37.8 0.0 4.4 4 0 0 4 4 4 3 NUC153 domain AAA PF00004.24 ESA10100.1 - 4.2e-45 153.1 0.9 2.2e-44 150.8 0.0 2.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA10100.1 - 1.3e-09 37.8 0.1 4.2e-09 36.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESA10100.1 - 2.2e-08 34.1 0.1 1.8e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESA10100.1 - 2.6e-07 30.8 0.0 1.7e-06 28.1 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ESA10100.1 - 8.6e-06 24.8 0.0 1.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.1 ESA10100.1 - 1.5e-05 25.1 4.1 0.00037 20.6 0.6 2.8 2 1 0 2 2 1 1 AAA domain AAA_28 PF13521.1 ESA10100.1 - 0.00014 21.8 0.2 0.0004 20.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA10100.1 - 0.00015 21.4 0.1 0.00038 20.1 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 ESA10100.1 - 0.00018 21.4 0.0 0.00067 19.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 ESA10100.1 - 0.00036 20.1 0.1 0.016 14.8 0.0 2.4 1 1 1 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 RuvB_N PF05496.7 ESA10100.1 - 0.00038 19.5 0.0 0.00095 18.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ESA10100.1 - 0.00052 20.8 0.0 0.0031 18.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 ESA10100.1 - 0.00059 19.2 0.6 0.012 14.9 0.0 2.4 1 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA10100.1 - 0.00095 19.3 0.0 0.0024 18.0 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 ESA10100.1 - 0.001 19.3 0.0 0.028 14.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA10100.1 - 0.001 18.6 0.1 0.0098 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 ESA10100.1 - 0.0021 17.7 0.0 0.0062 16.2 0.0 1.8 1 0 0 1 1 1 1 NTPase NACHT PF05729.7 ESA10100.1 - 0.0022 17.6 0.3 0.053 13.1 0.0 2.6 3 0 0 3 3 2 1 NACHT domain IstB_IS21 PF01695.12 ESA10100.1 - 0.0028 17.0 0.2 0.0096 15.3 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.8 ESA10100.1 - 0.0034 16.1 0.0 0.0064 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_33 PF13671.1 ESA10100.1 - 0.0045 16.8 0.0 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.6 ESA10100.1 - 0.0048 16.5 0.0 0.017 14.7 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 ESA10100.1 - 0.0066 15.6 0.0 0.016 14.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 ESA10100.1 - 0.0077 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 ESA10100.1 - 0.011 15.3 0.3 0.033 13.7 0.1 1.8 2 0 0 2 2 1 0 AAA domain Arch_ATPase PF01637.13 ESA10100.1 - 0.017 14.8 1.3 0.24 11.0 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase KaiC PF06745.8 ESA10100.1 - 0.021 13.9 1.5 0.45 9.6 0.0 2.8 3 0 0 3 3 3 0 KaiC Zeta_toxin PF06414.7 ESA10100.1 - 0.023 13.8 0.0 0.042 12.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.21 ESA10100.1 - 0.025 14.0 0.1 1.2 8.5 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_23 PF13476.1 ESA10100.1 - 0.029 14.6 5.6 0.7 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain GrpE PF01025.14 ESA10100.1 - 0.038 13.5 1.2 0.26 10.7 0.1 2.3 2 0 0 2 2 2 0 GrpE Bac_DnaA PF00308.13 ESA10100.1 - 0.047 13.3 0.0 0.092 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein ABC_tran PF00005.22 ESA10100.1 - 0.1 12.8 0.3 0.46 10.7 0.0 2.4 2 1 0 2 2 2 0 ABC transporter Parvo_NS1 PF01057.12 ESA10100.1 - 0.12 11.2 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_10 PF12846.2 ESA10100.1 - 0.13 11.6 0.9 1.1 8.6 0.0 2.5 2 1 1 3 3 3 0 AAA-like domain Sigma54_activ_2 PF14532.1 ESA10100.1 - 0.14 12.2 0.4 0.76 9.8 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Kinesin PF00225.18 ESA10101.1 - 3.2e-115 384.4 0.1 3.2e-115 384.4 0.0 2.8 3 1 1 4 4 4 1 Kinesin motor domain DUF2813 PF11398.3 ESA10102.1 - 0.038 13.0 5.5 0.059 12.4 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Chlamy_scaf PF09675.5 ESA10102.1 - 2.2 8.2 6.9 0.52 10.3 1.8 2.2 1 1 1 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Abhydrolase_2 PF02230.11 ESA10103.1 - 1e-62 211.3 0.0 1.2e-62 211.2 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 ESA10103.1 - 6.3e-11 42.2 0.0 9.8e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA10103.1 - 1.5e-07 31.5 0.1 5.9e-06 26.3 0.1 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.8 ESA10103.1 - 4.5e-06 26.2 0.0 1.5e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.16 ESA10103.1 - 3.3e-05 23.1 0.0 0.0001 21.5 0.0 1.9 2 1 1 3 3 3 1 Prolyl oligopeptidase family Cutinase PF01083.17 ESA10103.1 - 0.0082 15.9 0.0 0.018 14.7 0.0 1.5 2 0 0 2 2 2 1 Cutinase Abhydro_lipase PF04083.11 ESA10103.1 - 0.012 14.9 0.0 0.37 10.1 0.0 2.7 3 0 0 3 3 3 0 Partial alpha/beta-hydrolase lipase region LIP PF03583.9 ESA10103.1 - 0.015 14.4 0.0 0.033 13.3 0.0 1.5 2 0 0 2 2 2 0 Secretory lipase DLH PF01738.13 ESA10103.1 - 0.035 13.3 0.0 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family FA_desaturase PF00487.19 ESA10105.1 - 1.9e-32 112.7 15.6 3.3e-32 111.9 10.8 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Mannosyl_trans2 PF04188.8 ESA10106.1 - 1.6e-69 234.9 38.9 2.7e-50 171.5 17.2 2.0 1 1 1 2 2 2 2 Mannosyltransferase (PIG-V)) Velvet PF11754.3 ESA10109.1 - 7.8e-64 215.0 0.0 9.8e-64 214.6 0.0 1.1 1 0 0 1 1 1 1 Velvet factor Peptidase_M9_N PF08453.5 ESA10110.1 - 0.0079 15.5 0.2 0.017 14.5 0.2 1.6 1 0 0 1 1 1 1 Peptidase family M9 N-terminal LRR_6 PF13516.1 ESA10110.1 - 0.17 12.0 0.4 0.17 12.0 0.3 3.4 3 0 0 3 3 3 0 Leucine Rich repeat NYN PF01936.13 ESA10113.1 - 2.5e-10 40.7 0.0 1.6e-09 38.2 0.0 2.2 2 1 0 2 2 2 1 NYN domain TLD PF07534.11 ESA10117.1 - 2.5e-10 40.4 1.2 3.5e-10 40.0 0.8 1.2 1 0 0 1 1 1 1 TLD CTP_transf_3 PF02348.14 ESA10117.1 - 0.1 12.1 0.3 0.13 11.8 0.2 1.1 1 0 0 1 1 1 0 Cytidylyltransferase BTB PF00651.26 ESA10118.1 - 0.013 15.4 0.2 0.52 10.3 0.1 2.3 1 1 1 2 2 2 0 BTB/POZ domain Urm1 PF09138.6 ESA10118.1 - 0.062 13.4 0.1 0.098 12.7 0.1 1.4 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Bcl-2 PF00452.14 ESA10118.1 - 0.081 13.0 0.1 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family DUF1987 PF09345.5 ESA10118.1 - 0.1 12.4 0.7 0.16 11.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) ubiquitin PF00240.18 ESA10119.1 - 1.8e-13 49.6 0.1 2e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA10119.1 - 1.8e-06 27.5 0.2 1.9e-06 27.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA10119.1 - 0.034 14.3 0.2 0.056 13.7 0.1 1.4 1 1 0 1 1 1 0 Ubiquitin-like domain Response_reg PF00072.19 ESA10124.1 - 2.1e-17 63.1 0.1 2.8e-17 62.7 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Glycos_transf_1 PF00534.15 ESA10124.1 - 0.08 12.3 0.1 2 7.7 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferases group 1 Phtf-FEM1B_bdg PF12129.3 ESA10124.1 - 0.093 12.0 0.1 0.34 10.2 0.0 1.8 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor F-box-like PF12937.2 ESA10125.1 - 0.0024 17.5 0.8 0.008 15.8 0.5 1.9 1 0 0 1 1 1 1 F-box-like DUF4156 PF13698.1 ESA10125.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) LRR_6 PF13516.1 ESA10127.1 - 2.3 8.5 5.7 4.2 7.7 0.1 3.1 4 0 0 4 4 4 0 Leucine Rich repeat DUF659 PF04937.10 ESA10129.1 - 1.7e-07 30.8 1.2 1.9e-07 30.6 0.5 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Baculo_DNA_bind PF04786.7 ESA10129.1 - 0.013 14.6 0.3 0.015 14.4 0.2 1.1 1 0 0 1 1 1 0 ssDNA binding protein Cbl_N PF02262.11 ESA10129.1 - 0.075 12.7 0.3 0.087 12.5 0.2 1.2 1 0 0 1 1 1 0 CBL proto-oncogene N-terminal domain 1 DIM PF08194.7 ESA10130.1 - 0.061 13.2 1.4 0.087 12.7 1.0 1.2 1 0 0 1 1 1 0 DIM protein HMG-CoA_red PF00368.13 ESA10131.1 - 7.5e-165 548.0 7.3 1.1e-164 547.5 5.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Zip PF02535.17 ESA10131.1 - 0.94 8.4 16.4 2.6 6.9 11.4 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter Nop25 PF09805.4 ESA10132.1 - 1.2e-21 77.1 25.9 1.2e-21 77.1 18.0 2.3 2 1 0 2 2 2 1 Nucleolar protein 12 (25kDa) Holin_LLH PF09682.5 ESA10132.1 - 0.22 11.6 9.9 0.5 10.5 1.7 2.5 1 1 0 2 2 2 0 Phage holin protein (Holin_LLH) Vpu PF00558.14 ESA10132.1 - 3.5 7.2 6.6 11 5.7 4.5 1.9 1 0 0 1 1 1 0 Vpu protein DUF572 PF04502.8 ESA10132.1 - 8.1 5.5 31.5 10 5.2 21.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Surp PF01805.15 ESA10133.1 - 1.2e-27 95.3 0.3 2.4e-15 55.9 0.1 2.5 2 0 0 2 2 2 2 Surp module DRY_EERY PF09750.4 ESA10134.1 - 4.1e-11 43.0 0.3 1.8e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Alternative splicing regulator DUF4550 PF15084.1 ESA10134.1 - 0.048 13.7 0.1 0.082 13.0 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4550) WD40 PF00400.27 ESA10136.1 - 4.9e-26 89.6 1.1 3.7e-07 29.7 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat BTB PF00651.26 ESA10137.1 - 1.8e-19 69.7 1.8 2.3e-19 69.4 0.3 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA10137.1 - 3.2e-06 26.9 2.4 0.00067 19.4 0.1 3.8 1 1 3 4 4 4 1 BTB And C-terminal Kelch DEAD PF00270.24 ESA10139.1 - 3.9e-19 68.7 0.0 2.4e-18 66.1 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA10139.1 - 2.4e-11 43.8 0.0 2.4e-10 40.5 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Glyco_hydro_66 PF13199.1 ESA10139.1 - 0.039 12.3 0.0 0.061 11.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 IstB_IS21 PF01695.12 ESA10139.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein HTH_Tnp_Tc3_2 PF01498.13 ESA10141.1 - 2.2e-12 46.8 0.1 4.6e-12 45.8 0.0 1.6 2 0 0 2 2 2 1 Transposase HTH_29 PF13551.1 ESA10141.1 - 0.00016 21.7 0.0 0.00019 21.5 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.1 ESA10141.1 - 0.00036 21.2 0.0 0.00055 20.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain IpaB_EvcA PF03278.8 ESA10141.1 - 0.0016 17.6 0.0 0.0024 17.1 0.0 1.2 1 1 0 1 1 1 1 IpaB/EvcA family HTH_23 PF13384.1 ESA10141.1 - 0.004 16.7 0.0 0.011 15.3 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.1 ESA10141.1 - 0.01 15.3 1.5 0.014 14.9 0.0 2.0 3 0 0 3 3 3 0 Helix-turn-helix domain CaM-KIIN PF15170.1 ESA10141.1 - 0.014 15.3 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 Calcium/calmodulin-dependent protein kinase II inhibitor Sel1 PF08238.7 ESA10142.1 - 8e-142 458.6 62.6 1e-11 45.0 1.5 15.0 15 0 0 15 15 15 15 Sel1 repeat TPR_6 PF13174.1 ESA10142.1 - 5.4e-12 45.3 24.1 0.13 12.7 0.0 11.5 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10142.1 - 0.00017 22.1 4.7 2.7 8.7 0.0 5.8 6 1 1 7 7 7 2 Tetratricopeptide repeat STE PF02200.11 ESA10142.1 - 0.23 11.6 4.3 1.6 8.9 0.0 3.9 5 0 0 5 5 5 0 STE like transcription factor TRI5 PF06330.6 ESA10142.1 - 5 5.6 9.9 2.2 6.8 0.1 3.7 4 0 0 4 4 4 0 Trichodiene synthase (TRI5) Dimer_Tnp_hAT PF05699.9 ESA10144.1 - 1.8e-16 59.5 0.2 2.2e-16 59.2 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4349 PF14257.1 ESA10145.1 - 0.015 14.5 7.2 1.4 8.0 4.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) BTB PF00651.26 ESA10147.1 - 5.7e-19 68.1 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA10147.1 - 1.1e-15 57.8 3.0 2.4e-15 56.7 2.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA10147.1 - 0.00016 21.4 1.0 0.0014 18.4 0.2 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA10148.1 - 1.6e-07 31.4 0.6 8.8e-07 29.0 0.1 2.2 2 1 0 2 2 2 1 TLD Avidin PF01382.12 ESA10148.1 - 0.051 13.8 0.4 0.1 12.9 0.3 1.4 1 0 0 1 1 1 0 Avidin family Sel1 PF08238.7 ESA10149.1 - 2e-07 31.4 0.0 3.3e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 Sel1 repeat DUF2758 PF10957.3 ESA10149.1 - 0.077 12.8 0.9 3.9 7.3 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2758) Sel1 PF08238.7 ESA10150.1 - 2e-87 285.7 21.3 1.5e-13 50.8 0.5 8.6 9 0 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.1 ESA10150.1 - 0.0002 21.5 4.3 4.1 8.0 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat SLT PF01464.15 ESA10150.1 - 0.005 16.3 22.1 0.15 11.5 0.1 5.4 2 1 2 5 5 5 3 Transglycosylase SLT domain Amidase02_C PF12123.3 ESA10150.1 - 0.013 15.0 12.2 2.7 7.7 0.0 5.8 7 0 0 7 7 7 0 N-acetylmuramoyl-l-alanine amidase TPR_11 PF13414.1 ESA10150.1 - 0.72 9.5 17.8 0.44 10.2 0.4 5.6 3 3 3 6 6 6 0 TPR repeat UCH PF00443.24 ESA10152.1 - 2.5e-54 184.2 0.0 2.9e-54 184.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA10152.1 - 1e-18 67.8 0.0 2.6e-18 66.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2235 PF09994.4 ESA10153.1 - 2.1e-60 204.4 0.0 2.6e-60 204.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_5 PF12695.2 ESA10153.1 - 0.044 13.5 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ran_BP1 PF00638.13 ESA10155.1 - 2.8e-20 72.5 0.0 1e-19 70.7 0.0 2.0 1 0 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.1 ESA10155.1 - 2.5 8.3 25.2 7 6.9 17.6 1.6 1 1 0 1 1 1 0 Nucleoporin FG repeat region Med9 PF07544.8 ESA10156.1 - 0.0019 17.8 1.3 0.0026 17.4 0.9 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 BAG PF02179.11 ESA10156.1 - 0.012 15.6 0.2 0.012 15.6 0.1 1.6 2 0 0 2 2 2 0 BAG domain DUF848 PF05852.6 ESA10156.1 - 0.044 13.6 0.6 0.056 13.2 0.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) TRAM_LAG1_CLN8 PF03798.11 ESA10157.1 - 2e-10 40.5 21.1 2.7e-10 40.1 14.7 1.2 1 0 0 1 1 1 1 TLC domain VKOR PF07884.9 ESA10157.1 - 0.18 11.6 0.0 0.18 11.6 0.0 2.8 2 1 1 3 3 3 0 Vitamin K epoxide reductase family DUF3593 PF12159.3 ESA10157.1 - 1.6 8.5 7.5 0.21 11.4 1.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3593) Herpes_LMP1 PF05297.6 ESA10157.1 - 4.8 5.9 6.3 3.6 6.4 3.7 1.3 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) EamA PF00892.15 ESA10157.1 - 8.5 6.4 15.5 1.7 8.6 3.8 2.5 1 1 1 2 2 2 0 EamA-like transporter family DASH_Dad4 PF08650.5 ESA10158.1 - 0.0061 16.4 1.3 0.0061 16.4 0.9 2.9 3 0 0 3 3 3 1 DASH complex subunit Dad4 SurA_N_3 PF13624.1 ESA10158.1 - 0.035 14.0 0.5 0.035 14.0 0.4 2.4 1 1 0 3 3 3 0 SurA N-terminal domain BAR_3_WASP_bdg PF10456.4 ESA10158.1 - 0.043 13.0 2.0 0.95 8.6 0.3 2.6 1 1 1 2 2 2 0 WASP-binding domain of Sorting nexin protein Phasin_2 PF09361.5 ESA10158.1 - 0.061 13.3 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Phasin protein Laminin_II PF06009.7 ESA10158.1 - 0.09 12.5 7.5 0.43 10.3 0.2 2.9 3 1 0 3 3 3 0 Laminin Domain II CesA PF11439.3 ESA10158.1 - 3.4 7.6 6.4 2.7 7.9 0.0 3.4 4 0 0 4 4 4 0 Type III secretion system filament chaperone CesA DUF4441 PF14536.1 ESA10158.1 - 3.5 7.6 16.9 24 4.9 10.3 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) Spc7 PF08317.6 ESA10159.1 - 0.00085 18.0 3.0 0.0054 15.4 0.3 2.1 2 0 0 2 2 2 1 Spc7 kinetochore protein Fib_alpha PF08702.5 ESA10159.1 - 0.0083 16.2 5.5 0.14 12.2 1.5 2.9 1 1 1 3 3 3 2 Fibrinogen alpha/beta chain family Cor1 PF04803.7 ESA10159.1 - 0.019 14.7 2.6 0.21 11.3 0.5 2.3 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Baculo_PEP_C PF04513.7 ESA10159.1 - 0.025 14.3 0.8 0.41 10.4 0.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Mer2 PF09074.5 ESA10159.1 - 0.058 13.3 2.4 0.4 10.5 0.3 2.5 1 1 1 2 2 2 0 Mer2 V-SNARE PF05008.10 ESA10159.1 - 0.33 11.1 3.3 20 5.4 0.0 3.2 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Orthopox_A5L PF06193.6 ESA10160.1 - 0.00029 20.8 1.5 0.00029 20.8 1.0 2.7 4 0 0 4 4 3 1 Orthopoxvirus A5L protein-like Mer2 PF09074.5 ESA10160.1 - 0.00035 20.5 2.7 0.00072 19.5 1.9 1.5 1 0 0 1 1 1 1 Mer2 Spectrin PF00435.16 ESA10160.1 - 0.014 15.6 1.3 0.03 14.6 0.9 1.6 1 0 0 1 1 1 0 Spectrin repeat CR6_interact PF10147.4 ESA10160.1 - 0.017 14.4 5.2 0.026 13.8 3.6 1.2 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Effector_1 PF04518.7 ESA10160.1 - 0.024 13.6 4.5 0.033 13.1 3.1 1.2 1 0 0 1 1 1 0 Effector from type III secretion system DUF745 PF05335.8 ESA10160.1 - 0.062 12.8 2.4 0.09 12.2 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Peptidase_S49 PF01343.13 ESA10160.1 - 0.073 12.8 0.3 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 MRAP PF15183.1 ESA10160.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family zf-CpG_bind_C PF12269.3 ESA10160.1 - 0.15 11.4 4.4 0.22 10.9 3.0 1.2 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain THOC7 PF05615.8 ESA10160.1 - 0.18 12.0 7.7 0.25 11.5 4.4 1.8 1 1 0 1 1 1 0 Tho complex subunit 7 HTH_19 PF12844.2 ESA10160.1 - 0.2 11.7 3.7 0.44 10.6 1.0 2.5 2 1 1 3 3 3 0 Helix-turn-helix domain Syntaxin-6_N PF09177.6 ESA10160.1 - 0.22 11.9 7.7 1.9 8.9 0.4 2.8 2 1 1 3 3 2 0 Syntaxin 6, N-terminal Nsp1_C PF05064.8 ESA10160.1 - 0.51 9.9 5.9 3 7.5 1.4 2.5 1 1 1 2 2 2 0 Nsp1-like C-terminal region Fib_alpha PF08702.5 ESA10160.1 - 0.59 10.2 8.5 2.1 8.4 1.9 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CorA PF01544.13 ESA10160.1 - 0.98 8.3 9.1 0.63 9.0 1.3 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein IncA PF04156.9 ESA10160.1 - 1.1 8.7 8.8 1.3 8.5 2.1 2.6 2 1 1 3 3 3 0 IncA protein DUF2935 PF11155.3 ESA10160.1 - 2.7 8.1 7.4 3.3 7.8 2.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF972 PF06156.8 ESA10160.1 - 4 7.8 7.6 4 7.8 2.9 2.6 2 1 1 3 3 2 0 Protein of unknown function (DUF972) WEMBL PF05701.6 ESA10161.1 - 0.0081 14.6 5.1 0.021 13.3 3.3 1.7 1 1 1 2 2 2 1 Weak chloroplast movement under blue light Cob_adeno_trans PF01923.13 ESA10161.1 - 0.016 15.0 0.9 0.093 12.5 0.1 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF1627 PF07789.7 ESA10161.1 - 0.038 13.5 0.1 2.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1627) PFEMP PF03011.10 ESA10161.1 - 0.15 12.3 9.3 0.17 12.2 0.4 2.8 2 1 0 2 2 2 0 PFEMP DBL domain PMAIP1 PF15150.1 ESA10161.1 - 0.26 11.0 2.0 11 5.9 0.0 2.7 3 0 0 3 3 3 0 Phorbol-12-myristate-13-acetate-induced Mnd1 PF03962.10 ESA10161.1 - 0.5 9.9 7.0 0.063 12.9 1.1 2.2 2 1 0 2 2 2 0 Mnd1 family RP-C_C PF11800.3 ESA10161.1 - 0.52 9.9 4.7 0.69 9.5 0.4 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region Globin PF00042.17 ESA10161.1 - 1.3 9.3 0.0 1.3 9.3 0.0 2.8 4 0 0 4 4 4 0 Globin Alveol-reg_P311 PF11092.3 ESA10162.1 - 0.069 13.1 0.2 0.34 10.9 0.1 2.2 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) Ribosomal_L13 PF00572.13 ESA10164.1 - 4.7e-51 172.1 1.5 5.8e-51 171.8 0.1 1.7 1 1 1 2 2 2 1 Ribosomal protein L13 tRNA_bind PF01588.15 ESA10165.1 - 1e-30 105.4 0.0 2e-30 104.4 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.1 ESA10165.1 - 3.9e-06 27.2 1.0 5.3e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESA10165.1 - 6.5e-06 26.0 0.1 1.8e-05 24.6 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SpoA PF01052.15 ESA10165.1 - 0.11 12.0 0.1 0.5 9.9 0.0 2.0 2 0 0 2 2 2 0 Surface presentation of antigens (SPOA) Phage_GPD PF05954.6 ESA10165.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) Ku_C PF03730.9 ESA10165.1 - 0.34 11.4 6.4 0.099 13.1 1.9 1.9 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Arg_repressor PF01316.16 ESA10166.1 - 0.05 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF928 PF06051.7 ESA10166.1 - 0.11 12.1 0.6 8.8 5.8 0.1 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF928) DUF3398 PF11878.3 ESA10167.1 - 0.094 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) DOG1 PF14144.1 ESA10169.1 - 0.049 13.6 0.2 4.2 7.4 0.0 2.6 2 0 0 2 2 2 0 Seed dormancy control Pex19 PF04614.7 ESA10169.1 - 0.12 11.9 1.8 0.12 11.9 0.3 1.5 1 1 0 1 1 1 0 Pex19 protein family Kelch_5 PF13854.1 ESA10170.1 - 4.7e-07 29.6 2.4 0.00058 19.7 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.1 ESA10170.1 - 2.2e-06 27.3 3.9 4.3e-05 23.2 0.0 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA10170.1 - 0.0083 15.8 0.2 1.9 8.3 0.0 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA10170.1 - 0.048 13.8 7.1 0.42 10.8 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.1 ESA10170.1 - 0.17 12.0 7.5 7 6.9 0.4 4.1 4 1 0 4 4 4 0 Galactose oxidase, central domain Reo_sigmaC PF04582.7 ESA10171.1 - 0.14 11.3 0.5 0.14 11.3 0.3 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 ESA10171.1 - 0.15 12.1 3.0 0.19 11.8 2.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.3 ESA10171.1 - 0.42 10.4 4.2 0.52 10.1 2.5 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DIRP PF06584.8 ESA10173.1 - 0.00018 21.3 5.4 0.00026 20.7 3.7 1.3 1 0 0 1 1 1 1 DIRP Stb3 PF10330.4 ESA10173.1 - 0.0037 16.9 1.2 1.2 8.9 0.1 2.4 1 1 0 2 2 2 2 Putative Sin3 binding protein DUF3728 PF12528.3 ESA10173.1 - 0.03 14.6 7.1 0.46 10.9 0.4 2.2 1 1 1 2 2 2 0 Prepilin peptidase dependent protein C (DUF3728) DUF503 PF04456.7 ESA10173.1 - 0.044 13.3 3.4 0.055 13.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF503) LptE PF04390.7 ESA10173.1 - 4.3 7.0 8.6 12 5.6 3.6 2.4 2 1 0 2 2 2 0 Lipopolysaccharide-assembly Ferrochelatase PF00762.14 ESA10175.1 - 0.098 11.6 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Ferrochelatase Hist_deacetyl PF00850.14 ESA10175.1 - 0.15 11.2 0.1 0.18 11.0 0.1 1.1 1 0 0 1 1 1 0 Histone deacetylase domain Uds1 PF15456.1 ESA10176.1 - 8e-21 74.3 6.6 8e-21 74.3 4.6 9.6 4 2 3 9 9 9 1 Up-regulated During Septation Reo_sigmaC PF04582.7 ESA10176.1 - 2.1e-05 23.9 44.4 0.018 14.2 0.1 6.4 4 1 2 7 7 7 6 Reovirus sigma C capsid protein HR1 PF02185.11 ESA10176.1 - 0.00011 21.8 2.0 0.00011 21.8 1.4 10.6 8 3 2 10 10 10 1 Hr1 repeat Fib_alpha PF08702.5 ESA10176.1 - 0.0028 17.7 2.4 0.0028 17.7 1.7 8.6 4 1 6 10 10 10 2 Fibrinogen alpha/beta chain family ATG16 PF08614.6 ESA10176.1 - 0.0037 17.0 9.7 0.0037 17.0 6.8 8.0 1 1 4 7 7 7 3 Autophagy protein 16 (ATG16) DUF4200 PF13863.1 ESA10176.1 - 0.0046 16.8 11.2 0.0046 16.8 7.7 8.6 7 1 1 8 8 8 2 Domain of unknown function (DUF4200) WEMBL PF05701.6 ESA10176.1 - 2.1 6.6 128.0 0.72 8.2 31.6 5.5 2 1 4 6 6 6 0 Weak chloroplast movement under blue light DUF1644 PF07800.7 ESA10177.1 - 0.5 10.2 3.6 6.8 6.5 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) GASA PF02704.9 ESA10177.1 - 1.5 8.8 5.3 2.7 8.0 3.7 1.7 1 1 0 1 1 1 0 Gibberellin regulated protein Med4 PF10018.4 ESA10178.1 - 8.1 5.7 7.7 3.1 7.1 0.3 2.4 2 1 0 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 Sel1 PF08238.7 ESA10179.1 - 1.2e-50 168.8 35.2 7.8e-13 48.6 2.0 5.5 6 0 0 6 6 6 4 Sel1 repeat MIT PF04212.13 ESA10179.1 - 5.9e-05 22.8 17.7 2 8.3 0.2 4.9 4 1 0 4 4 4 4 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA10179.1 - 0.00073 19.2 4.7 22 4.8 0.0 4.4 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation Peptidase_C14 PF00656.17 ESA10179.1 - 0.0031 17.2 0.0 0.11 12.1 0.0 2.6 1 1 0 1 1 1 1 Caspase domain Phage_T4_gp19 PF06841.7 ESA10179.1 - 0.0073 15.9 3.2 7.9 6.1 0.0 3.5 1 1 2 3 3 3 1 T4-like virus tail tube protein gp19 TPR_12 PF13424.1 ESA10179.1 - 0.011 15.7 20.2 0.32 10.9 3.6 4.0 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA10179.1 - 0.027 14.9 12.7 8.8 7.0 0.4 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA10179.1 - 0.081 13.0 1.7 5.5 7.1 0.0 2.9 1 1 1 3 3 3 0 Tetratricopeptide repeat MM_CoA_mutase PF01642.17 ESA10179.1 - 0.27 9.3 5.6 0.19 9.8 0.7 2.0 1 1 1 2 2 2 0 Methylmalonyl-CoA mutase HTH_16 PF12645.2 ESA10179.1 - 0.28 11.1 9.7 8.3 6.4 0.1 4.6 4 1 1 5 5 5 0 Helix-turn-helix domain Toxin_51 PF15531.1 ESA10179.1 - 0.39 10.5 8.3 8.6 6.1 0.2 3.2 1 1 2 3 3 3 0 Putative toxin 51 TPR_17 PF13431.1 ESA10179.1 - 0.83 10.0 22.7 4.7 7.6 0.3 6.0 5 3 0 5 5 5 0 Tetratricopeptide repeat BACK PF07707.10 ESA10182.1 - 1.7e-05 24.5 4.5 0.0014 18.3 1.5 2.7 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA10182.1 - 0.00041 20.3 0.4 0.38 10.7 0.0 2.3 1 1 1 2 2 2 2 TLD F-box-like PF12937.2 ESA10183.1 - 0.00013 21.6 1.9 0.00037 20.1 0.4 2.5 2 0 0 2 2 2 1 F-box-like MreB_Mbl PF06723.8 ESA10184.1 - 0.00081 18.0 0.0 0.4 9.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DUF912 PF06024.7 ESA10187.1 - 0.00077 19.4 3.4 0.0011 19.0 2.4 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) FimP PF09766.4 ESA10187.1 - 0.015 14.3 0.4 0.017 14.1 0.3 1.0 1 0 0 1 1 1 0 Fms-interacting protein BP28CT PF08146.7 ESA10187.1 - 0.047 13.4 0.2 0.069 12.8 0.1 1.3 1 1 0 1 1 1 0 BP28CT (NUC211) domain ARPC4 PF05856.7 ESA10188.1 - 1.5e-45 154.6 3.1 1.6e-45 154.5 2.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) P34-Arc PF04045.9 ESA10188.1 - 0.08 12.2 0.1 0.089 12.0 0.0 1.0 1 0 0 1 1 1 0 Arp2/3 complex, 34 kD subunit p34-Arc ATP-synt_10 PF05176.9 ESA10189.1 - 3.3e-52 177.2 0.3 3.9e-52 177.0 0.2 1.0 1 0 0 1 1 1 1 ATP10 protein McrBC PF10117.4 ESA10189.1 - 0.067 12.1 0.1 0.074 11.9 0.1 1.3 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component YtfJ_HI0045 PF09695.5 ESA10189.1 - 0.082 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) NAP PF00956.13 ESA10190.1 - 8.8e-90 300.0 9.6 8.8e-90 300.0 6.6 2.0 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) AATF-Che1 PF13339.1 ESA10190.1 - 0.014 15.5 1.5 0.033 14.3 1.0 1.5 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor zf-U1 PF06220.7 ESA10191.1 - 0.038 13.5 4.0 0.069 12.7 2.8 1.4 1 0 0 1 1 1 0 U1 zinc finger DUF1801 PF08818.6 ESA10191.1 - 0.44 10.6 5.8 3.3 7.8 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DU1801) ubiquitin PF00240.18 ESA10192.1 - 1.8e-12 46.4 0.2 1.8e-12 46.4 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 ESA10192.1 - 6.5e-07 28.9 0.3 2e-06 27.3 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ESA10192.1 - 4.8e-05 22.8 1.3 0.00059 19.3 0.0 2.7 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain G_glu_transpept PF01019.16 ESA10193.1 - 3.1e-82 276.6 0.0 3.5e-82 276.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RPAP1_N PF08621.5 ESA10194.1 - 0.034 13.7 3.5 3.4 7.3 0.3 3.0 2 0 0 2 2 2 0 RPAP1-like, N-terminal p450 PF00067.17 ESA10195.1 - 1.3e-18 66.8 0.0 1.3e-18 66.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA10196.1 - 3e-20 72.1 0.0 7e-20 70.9 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Dicty_CAR PF05462.6 ESA10196.1 - 0.028 13.3 0.1 0.055 12.3 0.1 1.4 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor UvrD_C PF13361.1 ESA10197.1 - 5e-13 49.2 2.1 2.8e-09 36.9 0.0 3.2 3 0 0 3 3 3 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 ESA10197.1 - 4.6e-07 29.9 0.3 7.9e-06 25.9 0.2 2.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ESA10197.1 - 1.4e-06 27.8 1.3 1.4e-06 27.8 0.9 3.8 4 1 1 5 5 5 1 UvrD/REP helicase N-terminal domain CppA_N PF14506.1 ESA10197.1 - 0.0058 16.2 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 CppA N-terminal ResIII PF04851.10 ESA10197.1 - 0.0088 15.8 0.3 0.034 13.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_12 PF13087.1 ESA10197.1 - 0.011 15.1 0.0 0.51 9.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain TPR_2 PF07719.12 ESA10197.1 - 0.011 15.6 4.1 2.1 8.4 0.9 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA10197.1 - 0.014 15.0 8.5 0.52 10.0 0.1 3.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10197.1 - 0.039 13.5 4.7 2.1 8.0 0.1 3.1 3 0 0 3 3 3 0 TPR repeat AAA_22 PF13401.1 ESA10197.1 - 0.044 13.9 0.2 0.37 10.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 ESA10197.1 - 0.044 13.2 0.9 9.5 5.6 0.0 3.8 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase DUF258 PF03193.11 ESA10197.1 - 0.084 12.0 0.0 7.6 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 TPR_8 PF13181.1 ESA10197.1 - 0.13 12.0 3.6 13 5.8 1.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.1 ESA10197.1 - 4.5 6.3 16.4 0.33 10.0 2.1 3.2 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP DUF2697 PF10906.3 ESA10199.1 - 0.00018 21.4 0.2 0.00022 21.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2697) DUF4574 PF15141.1 ESA10199.1 - 0.065 12.9 0.1 0.087 12.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4574) Bromo_TP PF07524.8 ESA10199.1 - 0.13 11.9 0.1 0.32 10.7 0.0 1.6 1 1 1 2 2 2 0 Bromodomain associated Ssl1 PF04056.9 ESA10200.1 - 6.8e-85 283.5 0.0 9e-85 283.1 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 ESA10200.1 - 2.1e-19 69.2 8.6 2.1e-19 69.2 6.0 2.6 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 ESA10200.1 - 1.7e-07 31.5 0.0 2.7e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.9 ESA10200.1 - 0.0021 17.4 3.7 0.0038 16.5 2.4 1.4 1 1 0 1 1 1 1 Transcription factor Tfb4 Ku_N PF03731.10 ESA10200.1 - 0.076 12.4 0.0 0.19 11.1 0.0 1.7 1 1 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain IBR PF01485.16 ESA10200.1 - 5.1 7.0 18.3 0.35 10.7 5.7 2.8 2 1 0 2 2 2 0 IBR domain DUF1690 PF07956.6 ESA10201.1 - 1.5e-11 44.4 8.0 1.4e-10 41.2 4.0 2.1 2 0 0 2 2 2 1 Protein of Unknown function (DUF1690) CHCH PF06747.8 ESA10201.1 - 0.0031 17.3 0.2 0.005 16.7 0.1 1.3 1 0 0 1 1 1 1 CHCH domain Rootletin PF15035.1 ESA10201.1 - 0.028 14.3 10.5 0.041 13.8 7.3 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion KMP11 PF03037.11 ESA10201.1 - 0.14 12.7 0.8 0.74 10.4 0.1 2.1 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 AHSA1 PF08327.6 ESA10202.1 - 3.9e-11 43.1 0.1 4.7e-11 42.8 0.1 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Pkinase PF00069.20 ESA10204.1 - 4.3e-29 101.4 0.4 8.3e-29 100.5 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10204.1 - 9.7e-28 96.9 0.1 1.4e-27 96.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA10204.1 - 1.4e-20 73.1 22.7 5.7e-06 26.8 0.5 6.8 6 1 0 6 6 6 5 Sel1 repeat YjgP_YjgQ PF03739.9 ESA10204.1 - 5.2 5.7 6.3 11 4.6 4.4 1.6 1 1 0 1 1 1 0 Predicted permease YjgP/YjgQ family TPR_6 PF13174.1 ESA10204.1 - 7 7.3 6.5 11 6.7 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TLD PF07534.11 ESA10205.1 - 3.5e-18 65.9 1.0 2.2e-15 56.8 0.1 3.6 2 2 1 3 3 3 1 TLD BTB PF00651.26 ESA10205.1 - 2.4e-15 56.4 0.0 5e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA10205.1 - 0.00052 19.8 4.8 0.0049 16.6 1.6 3.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch TctB PF07331.6 ESA10206.1 - 0.067 12.8 2.2 0.091 12.4 1.5 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Pkinase_Tyr PF07714.12 ESA10208.1 - 3.9e-42 144.0 0.0 4.9e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10208.1 - 3.2e-39 134.6 0.1 4.8e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA10209.1 - 1.1e-24 86.9 0.1 1.2e-24 86.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10209.1 - 9.8e-19 67.4 0.0 1.1e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA10209.1 - 0.0052 16.5 0.1 0.0068 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family PsbU PF06514.6 ESA10209.1 - 0.044 13.6 0.8 0.17 11.7 0.1 2.2 2 1 1 3 3 3 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pkinase_Tyr PF07714.12 ESA10210.1 - 7.4e-44 149.7 0.6 2.4e-43 148.0 0.1 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10210.1 - 2.6e-36 125.1 0.4 5.5e-36 124.0 0.3 1.5 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA10210.1 - 8.1e-08 32.6 3.3 0.00082 19.9 0.4 3.3 3 0 0 3 3 3 2 Sel1 repeat Kdo PF06293.9 ESA10210.1 - 0.0015 17.6 0.4 0.0037 16.3 0.3 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA10210.1 - 0.0022 17.0 0.0 0.004 16.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Mad3_BUB1_II PF08171.6 ESA10210.1 - 0.013 15.4 1.0 0.091 12.6 0.4 2.3 2 0 0 2 2 2 0 Mad3/BUB1 homology region 2 TPR_19 PF14559.1 ESA10210.1 - 0.097 13.0 0.8 4.5 7.6 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1768 PF08719.6 ESA10211.1 - 3.8e-41 140.4 0.1 4.3e-41 140.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DUF3862 PF12978.2 ESA10211.1 - 0.037 13.6 0.0 0.04 13.5 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) Phage_30_3 PF08010.6 ESA10211.1 - 0.039 13.4 0.0 0.084 12.3 0.0 1.5 1 1 0 1 1 1 0 Bacteriophage protein GP30.3 Pil1 PF13805.1 ESA10211.1 - 0.046 12.8 0.0 0.054 12.6 0.0 1.1 1 0 0 1 1 1 0 Eisosome component PIL1 DUF1741 PF08427.5 ESA10212.1 - 6e-52 176.4 0.1 1.7e-51 174.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Kelch_4 PF13418.1 ESA10213.1 - 5.1e-09 35.7 0.2 2.8e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA10213.1 - 2e-08 34.1 1.1 0.00031 20.7 0.0 3.9 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA10213.1 - 7.8e-06 25.7 0.2 0.00055 19.8 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.1 ESA10213.1 - 2.4e-05 24.2 0.4 0.01 15.9 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA10213.1 - 0.065 13.0 2.5 1.3 8.8 0.0 3.5 3 1 1 4 4 4 0 Kelch motif XH PF03469.9 ESA10214.1 - 0.09 12.4 1.0 0.65 9.6 0.7 2.4 1 1 0 1 1 1 0 XH domain p450 PF00067.17 ESA10217.1 - 0.025 13.1 0.1 0.025 13.1 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.17 ESA10218.1 - 1.1e-62 212.1 0.0 1.3e-62 211.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Proteasom_PSMB PF10508.4 ESA10218.1 - 0.0066 14.7 0.2 0.01 14.1 0.1 1.3 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit DUF4250 PF14056.1 ESA10220.1 - 0.14 11.9 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF2362 PF10154.4 ESA10220.1 - 0.15 10.7 0.0 0.15 10.7 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Sel1 PF08238.7 ESA10222.1 - 2.7e-66 218.5 24.0 1.1e-12 48.0 0.1 7.0 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA10222.1 - 3e-10 39.8 8.7 0.0098 16.3 0.1 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10222.1 - 4.5e-05 23.0 20.4 0.0029 17.2 1.8 4.4 1 1 3 4 4 4 3 TPR repeat TPR_16 PF13432.1 ESA10222.1 - 8e-05 23.1 0.0 1.2 9.9 0.0 4.3 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA10222.1 - 0.00017 21.1 2.4 1.8 8.5 0.0 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat Fucose_iso_N2 PF07882.7 ESA10222.1 - 0.00088 18.9 2.5 0.71 9.5 0.1 3.2 1 1 2 3 3 3 2 L-fucose isomerase, second N-terminal domain MKT1_C PF12246.3 ESA10222.1 - 0.0069 15.4 1.9 1.6 7.6 0.0 2.9 1 1 2 3 3 3 2 Temperature dependent protein affecting M2 dsRNA replication PPR PF01535.15 ESA10222.1 - 0.017 15.0 0.6 11 6.2 0.1 4.1 4 0 0 4 4 4 0 PPR repeat Pec_lyase PF09492.5 ESA10222.1 - 0.019 14.1 1.6 1.4 8.0 0.1 3.2 1 1 2 3 3 3 0 Pectic acid lyase TPR_12 PF13424.1 ESA10222.1 - 0.023 14.6 15.3 1.4 8.9 0.9 5.7 3 2 2 5 5 4 0 Tetratricopeptide repeat DIL PF01843.14 ESA10222.1 - 0.053 13.4 0.6 20 5.1 0.0 3.2 2 1 1 3 3 3 0 DIL domain MIT PF04212.13 ESA10222.1 - 0.08 12.8 24.1 3.7 7.4 0.2 6.8 6 2 2 8 8 8 0 MIT (microtubule interacting and transport) domain DUF512 PF04459.7 ESA10222.1 - 0.087 11.8 0.2 1.3 8.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF512) ArsD PF06953.6 ESA10222.1 - 0.15 12.2 0.1 3.5 7.8 0.0 2.4 2 1 0 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD TPR_17 PF13431.1 ESA10222.1 - 0.44 10.8 14.3 4.5 7.7 0.2 6.7 4 2 3 7 7 6 0 Tetratricopeptide repeat DUF4071 PF13281.1 ESA10222.1 - 0.89 8.3 8.1 11 4.7 1.5 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4071) TPR_1 PF00515.23 ESA10222.1 - 1.7 8.3 41.0 7.3 6.3 0.1 9.8 12 0 0 12 12 12 0 Tetratricopeptide repeat PH PF00169.24 ESA10223.1 - 1.5e-23 82.9 25.7 5.6e-15 55.4 1.0 5.0 4 1 0 4 4 4 2 PH domain PH_8 PF15409.1 ESA10223.1 - 3.4e-13 49.4 6.0 6.4e-07 29.3 0.2 3.1 3 0 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.1 ESA10223.1 - 1.7e-11 43.9 5.8 7.6e-08 32.1 0.3 3.1 2 1 0 2 2 2 2 PH domain PH_11 PF15413.1 ESA10223.1 - 3.3e-09 36.9 21.5 0.0023 18.1 2.2 5.7 3 2 1 4 4 4 3 Pleckstrin homology domain PH_6 PF15406.1 ESA10223.1 - 1.2e-08 34.9 0.2 0.00093 19.2 0.0 3.2 2 1 0 2 2 2 2 Pleckstrin homology domain DUF972 PF06156.8 ESA10223.1 - 0.0064 16.8 8.1 0.0064 16.8 5.6 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF972) Sec3-PIP2_bind PF15277.1 ESA10223.1 - 0.094 12.5 9.3 1.4 8.8 0.3 3.9 3 2 0 3 3 3 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH Ehbp PF10622.4 ESA10223.1 - 1.3 9.0 4.4 27 4.8 0.0 3.5 3 1 1 4 4 4 0 Energy-converting hydrogenase B subunit P (EhbP) PH_4 PF15404.1 ESA10223.1 - 3.7 7.0 23.8 7.3 6.0 4.7 5.6 3 2 1 4 4 4 0 Pleckstrin homology domain zf-BED PF02892.10 ESA10226.1 - 0.032 13.9 0.3 0.06 13.1 0.2 1.5 1 0 0 1 1 1 0 BED zinc finger Seadorna_Vp10 PF07322.6 ESA10226.1 - 0.037 13.2 1.2 0.044 13.0 0.8 1.1 1 0 0 1 1 1 0 Seadornavirus Vp10 MS_channel PF00924.13 ESA10226.1 - 0.13 11.5 0.2 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel p450 PF00067.17 ESA10228.1 - 2e-06 26.6 0.0 2.1e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA10229.1 - 1.4e-31 109.5 0.1 1.6e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TOM13 PF08219.6 ESA10230.1 - 9.7e-18 63.7 0.0 1.6e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Outer membrane protein TOM13 NAD_binding_1 PF00175.16 ESA10231.1 - 1.5e-28 99.5 0.0 1.9e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA10231.1 - 6.1e-08 32.7 0.0 8.3e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.19 ESA10231.1 - 4.3e-05 23.5 0.1 8.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Sel1 PF08238.7 ESA10232.1 - 1.7e-94 308.1 40.1 4.8e-11 42.9 0.1 10.5 11 0 0 11 11 11 10 Sel1 repeat TPR_6 PF13174.1 ESA10232.1 - 1.4e-08 34.5 13.8 0.49 10.9 0.1 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10232.1 - 0.00024 20.6 34.8 0.00042 19.8 2.1 5.8 4 1 1 5 5 5 2 TPR repeat TPR_2 PF07719.12 ESA10232.1 - 0.0067 16.2 0.8 0.0067 16.2 0.5 10.1 14 0 0 14 14 14 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA10232.1 - 0.012 15.2 1.4 0.012 15.2 1.0 11.3 14 0 0 14 14 14 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA10232.1 - 0.045 13.5 7.8 4.4 7.3 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA10232.1 - 0.048 13.5 0.3 0.048 13.5 0.2 6.5 3 3 4 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10232.1 - 0.1 13.3 9.1 5.6 7.7 0.1 5.1 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA10232.1 - 0.54 10.2 9.2 2.5 8.1 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat p450 PF00067.17 ESA10233.1 - 2.4e-28 98.8 0.1 2.6e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA10234.1 - 1.5e-39 135.8 0.0 1.6e-39 135.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA10235.1 - 2.7e-25 88.8 0.1 3e-25 88.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Plasmodium_Vir PF05795.6 ESA10236.1 - 0.023 13.9 0.8 0.064 12.4 0.5 1.8 1 1 0 1 1 1 0 Plasmodium vivax Vir protein MOSC_N PF03476.11 ESA10236.1 - 0.027 14.1 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 MOSC N-terminal beta barrel domain SAM_1 PF00536.25 ESA10237.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.5 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) YppG PF14179.1 ESA10237.1 - 0.024 15.2 6.0 0.033 14.8 4.1 1.2 1 0 0 1 1 1 0 YppG-like protein SCHIP-1 PF10148.4 ESA10239.1 - 0.056 12.8 2.8 0.059 12.7 1.9 1.0 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Sel1 PF08238.7 ESA10240.1 - 1.2e-111 362.6 45.7 2.4e-12 47.0 0.4 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA10240.1 - 7.5e-10 38.6 16.5 0.065 13.7 0.1 9.5 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10240.1 - 9.1e-05 23.0 0.7 6.3 7.6 0.0 5.4 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10240.1 - 0.00058 19.4 9.3 0.0033 17.0 0.5 7.2 3 2 5 8 8 8 3 TPR repeat TPR_17 PF13431.1 ESA10240.1 - 3.5 8.0 23.5 16 6.0 0.2 9.0 8 3 3 11 11 11 0 Tetratricopeptide repeat Glycoprotein_G PF00802.14 ESA10241.1 - 0.052 12.7 0.1 0.064 12.3 0.1 1.1 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G DUF1647 PF07801.6 ESA10243.1 - 3.6e-05 23.2 0.0 8.5e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) DUF904 PF06005.7 ESA10245.1 - 0.00081 19.6 9.0 0.0015 18.7 4.9 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF904) CENP-H PF05837.7 ESA10245.1 - 0.0089 16.1 2.9 0.0089 16.1 2.0 2.8 2 1 1 3 3 3 1 Centromere protein H (CENP-H) DASH_Dam1 PF08653.5 ESA10245.1 - 0.018 14.8 0.6 0.044 13.5 0.4 1.8 1 0 0 1 1 1 0 DASH complex subunit Dam1 CCDC155 PF14662.1 ESA10245.1 - 0.018 14.6 4.0 0.034 13.7 2.8 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 HALZ PF02183.13 ESA10245.1 - 0.023 14.4 5.0 1.1 9.0 0.4 4.0 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF972 PF06156.8 ESA10245.1 - 0.036 14.4 7.1 0.16 12.3 4.5 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF972) PspA_IM30 PF04012.7 ESA10245.1 - 0.039 13.3 2.7 0.052 12.8 1.9 1.3 1 0 0 1 1 1 0 PspA/IM30 family Phlebovirus_NSM PF07246.6 ESA10245.1 - 0.047 12.8 0.3 0.047 12.8 0.2 1.7 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M bZIP_1 PF00170.16 ESA10245.1 - 0.048 13.6 5.2 0.29 11.1 1.1 3.0 1 1 1 2 2 2 0 bZIP transcription factor HemX PF04375.9 ESA10245.1 - 0.069 11.7 2.2 0.11 11.1 1.5 1.2 1 0 0 1 1 1 0 HemX SR-25 PF10500.4 ESA10245.1 - 0.071 12.5 5.7 0.088 12.2 3.9 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Kinesin-relat_1 PF12711.2 ESA10245.1 - 0.078 13.3 3.0 0.35 11.2 2.1 2.2 1 1 0 1 1 1 0 Kinesin motor Herpes_UL92 PF03048.9 ESA10245.1 - 0.1 12.1 0.9 0.16 11.4 0.3 1.5 2 0 0 2 2 2 0 UL92 family DivIC PF04977.10 ESA10245.1 - 0.11 11.9 6.7 0.12 11.8 1.5 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF848 PF05852.6 ESA10245.1 - 0.12 12.1 4.8 0.053 13.3 1.4 1.8 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TSC22 PF01166.13 ESA10245.1 - 0.12 12.3 13.1 1.2 9.1 0.5 3.9 2 1 1 3 3 3 0 TSC-22/dip/bun family Baculo_PEP_C PF04513.7 ESA10245.1 - 0.15 11.8 1.9 0.22 11.3 0.8 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3450 PF11932.3 ESA10245.1 - 0.16 11.2 3.8 0.25 10.5 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) MCC-bdg_PDZ PF10506.4 ESA10245.1 - 0.19 11.5 0.3 0.19 11.5 0.2 2.6 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd PF12329.3 ESA10245.1 - 0.61 9.9 4.4 0.65 9.8 1.1 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Mod_r PF07200.8 ESA10245.1 - 0.63 9.9 7.5 0.26 11.1 3.2 1.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Striatin PF08232.7 ESA10245.1 - 0.66 10.2 7.5 2.2 8.6 5.1 2.0 1 1 0 1 1 1 0 Striatin family AKNA PF12443.3 ESA10245.1 - 1.6 8.7 6.2 3 7.8 0.8 2.7 2 1 1 3 3 3 0 AT-hook-containing transcription factor TBPIP PF07106.8 ESA10245.1 - 3.5 7.1 10.6 0.28 10.7 2.9 2.1 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin PF00804.20 ESA10245.1 - 5.4 7.2 8.9 1.3 9.2 2.9 2.4 2 2 0 2 2 2 0 Syntaxin IncA PF04156.9 ESA10245.1 - 8.1 5.9 11.7 0.56 9.7 4.5 1.8 2 1 0 2 2 2 0 IncA protein Ku_C PF03730.9 ESA10246.1 - 0.045 14.2 0.1 0.069 13.6 0.1 1.3 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm Pab87_oct PF13969.1 ESA10247.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Pab87 octamerisation domain DUF3654 PF12376.3 ESA10248.1 - 0.0025 17.6 0.5 0.0025 17.6 0.4 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3654) DZR PF12773.2 ESA10248.1 - 0.72 9.7 22.6 0.71 9.7 1.0 3.7 2 2 1 3 3 3 0 Double zinc ribbon PhnA_Zn_Ribbon PF08274.7 ESA10248.1 - 5.1 6.9 15.2 3.5 7.4 0.4 4.5 4 0 0 4 4 4 0 PhnA Zinc-Ribbon zf-C3HC4_3 PF13920.1 ESA10248.1 - 5.1 6.8 21.9 17 5.1 0.1 4.1 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 ESA10249.1 - 1e-36 126.4 0.0 1.6e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10249.1 - 2.7e-32 111.8 0.0 3.5e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA10249.1 - 0.0041 16.8 0.1 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA10249.1 - 0.067 12.5 0.1 0.096 12.0 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Dor1 PF04124.7 ESA10250.1 - 0.0097 14.3 0.1 0.01 14.2 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family DUF1869 PF08956.5 ESA10250.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) RVP PF00077.15 ESA10251.1 - 0.049 13.5 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 Retroviral aspartyl protease 6PF2K PF01591.13 ESA10253.1 - 1.3e-75 253.3 0.0 1.7e-75 252.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 ESA10253.1 - 2.9e-25 89.1 0.3 9.6e-25 87.5 0.1 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 ESA10253.1 - 4.1e-08 33.2 0.0 8.3e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESA10253.1 - 0.0027 16.9 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 ESA10253.1 - 0.0032 18.2 1.2 0.0085 16.8 0.0 2.3 2 1 0 2 2 2 1 AAA domain RE_HindIII PF09518.5 ESA10253.1 - 0.019 13.9 0.1 0.032 13.1 0.1 1.4 1 0 0 1 1 1 0 HindIII restriction endonuclease SpoU_methylase PF00588.14 ESA10254.1 - 6.4e-29 100.6 0.2 1.2e-28 99.8 0.1 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 ESA10254.1 - 3.2e-13 49.6 0.1 6.1e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding HTH_Tnp_Mu_2 PF09039.6 ESA10254.1 - 0.086 12.5 0.3 0.27 10.9 0.2 1.8 1 1 0 1 1 1 0 Mu DNA binding, I gamma subdomain DUF531 PF04407.7 ESA10254.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF531) TLD PF07534.11 ESA10255.1 - 1e-09 38.5 3.9 1.1e-09 38.3 1.8 1.8 2 0 0 2 2 2 1 TLD RNA_pol_Rpb1_3 PF04983.13 ESA10255.1 - 0.07 12.8 0.1 0.2 11.3 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 3 CAF1 PF04857.15 ESA10256.1 - 0.012 14.9 0.1 5.3 6.2 0.0 2.3 1 1 0 2 2 2 0 CAF1 family ribonuclease AnfG_VnfG PF03139.10 ESA10256.1 - 0.024 14.4 8.3 0.62 9.8 0.3 3.0 2 1 1 3 3 3 0 Vanadium/alternative nitrogenase delta subunit GHL15 PF14885.1 ESA10256.1 - 0.13 12.4 2.6 4.8 7.4 0.0 2.8 2 1 0 2 2 2 0 Hypothetical glycosyl hydrolase family 15 RdRP PF05183.7 ESA10257.1 - 7.2e-108 361.7 0.3 1e-107 361.2 0.2 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.17 ESA10257.1 - 0.0018 17.8 0.1 0.0061 16.1 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA10257.1 - 0.0019 18.1 0.0 0.0053 16.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FlgH PF02107.11 ESA10258.1 - 0.011 15.3 0.2 0.012 15.1 0.1 1.0 1 0 0 1 1 1 0 Flagellar L-ring protein DUF240 PF03086.9 ESA10260.1 - 0.13 11.9 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 MG032/MG096/MG288 family 2 Piwi PF02171.12 ESA10261.1 - 3.3e-83 279.1 1.2 5.8e-83 278.3 0.1 1.7 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.17 ESA10261.1 - 4.3e-24 84.3 0.6 8e-24 83.4 0.4 1.4 1 0 0 1 1 1 1 PAZ domain DUF2905 PF11146.3 ESA10261.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2905) ABC_membrane PF00664.18 ESA10262.1 - 8.6e-47 159.8 23.3 1.3e-23 83.8 3.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA10262.1 - 1e-34 119.8 0.0 2e-34 118.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESA10262.1 - 8.1e-08 31.7 6.8 4.9e-07 29.2 1.2 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESA10262.1 - 0.00031 20.1 0.3 0.00092 18.6 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 ESA10262.1 - 0.00035 20.6 0.0 0.9 9.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.4 ESA10262.1 - 0.0042 15.7 0.3 0.0095 14.5 0.0 1.6 2 0 0 2 2 2 1 Predicted ATPase of the ABC class DUF258 PF03193.11 ESA10262.1 - 0.014 14.6 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESA10262.1 - 0.014 15.3 0.1 0.043 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain DUF2955 PF11168.3 ESA10262.1 - 0.032 13.9 0.9 0.032 13.9 0.6 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2955) AAA_23 PF13476.1 ESA10262.1 - 0.039 14.2 0.2 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA10262.1 - 0.089 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.1 ESA10262.1 - 0.11 11.9 0.0 0.37 10.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESA10262.1 - 0.11 13.3 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain CobT PF06213.7 ESA10263.1 - 0.0067 15.5 2.1 0.008 15.3 1.4 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nop14 PF04147.7 ESA10263.1 - 0.0085 14.0 1.5 0.008 14.1 1.0 1.1 1 0 0 1 1 1 1 Nop14-like family Cwf_Cwc_15 PF04889.7 ESA10263.1 - 0.01 15.6 3.8 0.016 14.9 2.7 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF1510 PF07423.6 ESA10263.1 - 0.022 14.1 0.4 0.036 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DAG1 PF05454.6 ESA10263.1 - 0.023 13.8 0.3 0.032 13.3 0.2 1.1 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SpoIIIAH PF12685.2 ESA10263.1 - 0.025 14.0 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein GCIP PF13324.1 ESA10263.1 - 0.056 12.6 3.8 0.13 11.4 2.7 1.7 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting TRAP_alpha PF03896.11 ESA10263.1 - 0.11 11.4 1.8 0.16 10.9 1.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RXT2_N PF08595.6 ESA10263.1 - 0.29 10.9 3.0 0.61 9.8 2.1 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal p450 PF00067.17 ESA10264.1 - 1.2e-56 192.1 0.0 1.4e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CNH PF00780.17 ESA10265.1 - 3.9e-16 59.2 0.0 5.6e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 CNH domain SNAP PF14938.1 ESA10266.1 - 1.6e-27 96.3 14.0 2.2e-27 95.9 9.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESA10266.1 - 0.00079 19.3 5.7 0.00079 19.3 3.9 2.9 2 1 2 4 4 4 1 Tetratricopeptide repeat Clathrin PF00637.15 ESA10266.1 - 0.025 14.1 4.1 1.2 8.6 0.2 3.4 2 1 1 3 3 3 0 Region in Clathrin and VPS TPR_11 PF13414.1 ESA10266.1 - 0.057 13.0 12.0 0.2 11.3 5.2 3.6 1 1 2 3 3 3 0 TPR repeat TPR_7 PF13176.1 ESA10266.1 - 0.12 12.2 6.2 7 6.7 0.2 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA10266.1 - 0.14 12.0 2.5 4.6 7.3 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PhoU PF01895.14 ESA10266.1 - 0.19 12.1 1.3 5.5 7.5 0.0 3.4 3 1 0 3 3 2 0 PhoU domain MIT PF04212.13 ESA10266.1 - 0.2 11.5 11.7 14 5.6 1.8 4.4 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.1 ESA10266.1 - 0.2 12.3 4.8 19 6.2 0.2 4.4 3 1 2 5 5 4 0 Tetratricopeptide repeat NSF PF02071.15 ESA10266.1 - 0.23 12.1 24.1 8 7.5 0.2 6.8 6 2 2 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 ESA10266.1 - 0.3 10.9 9.5 9.1 6.3 0.5 4.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TOM20_plant PF06552.7 ESA10266.1 - 0.43 10.1 4.6 0.24 10.9 0.9 2.2 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_2 PF07719.12 ESA10266.1 - 0.76 9.8 16.8 12 6.1 0.3 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA10266.1 - 1.9 8.6 8.2 2.6 8.2 0.4 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESA10266.1 - 3.2 8.4 16.0 8.4 7.0 0.8 4.7 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA10266.1 - 4.9 6.9 19.5 1.1 8.9 1.6 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10266.1 - 5.2 7.8 8.0 1.2e+02 3.5 4.4 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3359 PF11839.3 ESA10266.1 - 7.1 7.0 12.2 12 6.2 3.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3359) SurA_N PF09312.6 ESA10267.1 - 0.0025 17.6 0.3 0.0033 17.2 0.2 1.2 1 0 0 1 1 1 1 SurA N-terminal domain Relaxase PF03432.9 ESA10267.1 - 0.019 14.3 0.2 0.021 14.1 0.2 1.1 1 0 0 1 1 1 0 Relaxase/Mobilisation nuclease domain Telomerase_RBD PF12009.3 ESA10267.1 - 0.077 12.9 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Telomerase ribonucleoprotein complex - RNA binding domain DUF802 PF05650.6 ESA10267.1 - 0.42 10.7 2.6 0.78 9.9 1.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF802) ATP-synt_8 PF00895.15 ESA10270.1 - 0.011 15.9 2.1 0.025 14.7 1.4 2.0 1 1 0 1 1 1 0 ATP synthase protein 8 F-box-like PF12937.2 ESA10272.1 - 0.00013 21.6 1.1 0.00033 20.3 0.8 1.8 1 0 0 1 1 1 1 F-box-like Amidinotransf PF02274.12 ESA10272.1 - 0.039 13.0 0.1 0.063 12.3 0.1 1.4 1 0 0 1 1 1 0 Amidinotransferase NOT2_3_5 PF04153.13 ESA10273.1 - 5.5e-39 133.1 3.2 7.7e-39 132.6 2.2 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family PRA1 PF03208.14 ESA10274.1 - 0.035 13.4 0.6 0.035 13.4 0.4 1.6 2 0 0 2 2 2 0 PRA1 family protein DUF4501 PF14946.1 ESA10275.1 - 0.047 13.1 1.1 0.052 13.0 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) RasGAP PF00616.14 ESA10277.1 - 4.8e-39 134.0 0.5 4.5e-38 130.9 0.1 2.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.1 ESA10277.1 - 2.1e-20 73.1 0.1 6.6e-20 71.5 0.1 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain MOR2-PAG1_C PF14225.1 ESA10277.1 - 5.4e-06 26.3 0.0 1.9e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 Cell morphogenesis C-terminal DDE_Tnp_IS240 PF13610.1 ESA10277.1 - 0.00097 19.1 1.0 0.0024 17.8 0.7 1.6 1 0 0 1 1 1 1 DDE domain CRAL_TRIO PF00650.15 ESA10277.1 - 0.021 14.3 0.1 0.047 13.1 0.1 1.6 1 0 0 1 1 1 0 CRAL/TRIO domain Bac_export_3 PF01313.14 ESA10277.1 - 0.56 9.9 3.7 0.6 9.8 0.1 2.8 3 0 0 3 3 3 0 Bacterial export proteins, family 3 DUF605 PF04652.11 ESA10278.1 - 4.2 6.6 24.9 6.4 6.0 17.2 1.3 1 0 0 1 1 1 0 Vta1 like Arb2 PF09757.4 ESA10280.1 - 2.8e-21 75.7 0.0 6.2e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 Arb2 domain Abhydrolase_6 PF12697.2 ESA10280.1 - 2.9e-05 24.0 0.0 3.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA10280.1 - 0.00039 20.0 0.0 0.00054 19.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA10280.1 - 0.027 14.2 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Coatomer_WDAD PF04053.9 ESA10281.1 - 1.1e-174 581.3 0.0 1.3e-174 581.1 0.0 1.0 1 0 0 1 1 1 1 Coatomer WD associated region Clathrin PF00637.15 ESA10281.1 - 0.00024 20.7 2.5 0.015 14.9 0.3 2.5 2 0 0 2 2 2 2 Region in Clathrin and VPS TPR_19 PF14559.1 ESA10281.1 - 0.13 12.6 1.5 25 5.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_A_bac PF01000.21 ESA10282.1 - 8.5e-35 119.2 0.0 1.3e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESA10282.1 - 3.5e-15 54.8 0.0 4.5e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain WH2 PF02205.15 ESA10283.1 - 3.3e-12 45.5 0.4 8.5e-12 44.2 0.3 1.8 1 0 0 1 1 1 1 WH2 motif Abhydrolase_3 PF07859.8 ESA10284.1 - 0.0025 17.4 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LMWSLP_N PF12211.3 ESA10285.1 - 0.43 10.3 2.2 7.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Low molecular weight S layer protein N terminal Mg296 PF09644.5 ESA10287.1 - 0.079 12.8 5.3 0.081 12.7 0.2 2.8 2 1 1 3 3 3 0 Mg296 protein Orn_DAP_Arg_deC PF00278.17 ESA10287.1 - 0.13 11.9 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain LRR_7 PF13504.1 ESA10287.1 - 2 8.9 10.5 29 5.4 0.0 6.1 5 1 0 5 5 5 0 Leucine rich repeat DUF1374 PF07118.6 ESA10288.1 - 0.002 18.2 0.4 0.002 18.2 0.3 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1374) DUF1640 PF07798.6 ESA10288.1 - 0.027 14.5 0.9 0.055 13.5 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Corona_S2 PF01601.11 ESA10288.1 - 0.046 11.8 2.8 0.081 11.0 1.9 1.4 1 1 0 1 1 1 0 Coronavirus S2 glycoprotein Baculo_PEP_C PF04513.7 ESA10288.1 - 2.7 7.8 7.6 0.34 10.7 0.9 2.4 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Trigger_C PF05698.9 ESA10288.1 - 7.5 6.3 8.5 1.4 8.7 2.5 2.2 2 1 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus Oxysterol_BP PF01237.13 ESA10290.1 - 3.6e-138 459.9 0.0 6.7e-138 459.0 0.0 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.24 ESA10290.1 - 3e-10 40.2 1.6 1.5e-09 37.9 0.1 2.4 2 0 0 2 2 2 1 PH domain PH_8 PF15409.1 ESA10290.1 - 1e-08 35.1 3.6 1.2e-08 34.9 0.1 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_5 PF13857.1 ESA10290.1 - 1.9e-05 24.7 0.0 7.4e-05 22.8 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 ESA10290.1 - 8.6e-05 22.1 0.0 0.0002 20.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.2 ESA10290.1 - 0.00013 22.2 0.0 0.0003 21.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA10290.1 - 0.00031 20.7 0.0 0.0014 18.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 ESA10290.1 - 0.0027 18.1 0.0 0.0082 16.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF2034 PF10356.4 ESA10291.1 - 1.8e-07 30.5 0.0 2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 ESA10291.1 - 3.1e-07 30.2 0.0 3.8e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Restriction endonuclease Microtub_bind PF13931.1 ESA10292.1 - 0.3 11.2 4.5 0.11 12.5 0.8 1.9 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding Pox_Ag35 PF03286.9 ESA10292.1 - 2.2 7.7 7.6 1.9 7.9 2.4 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein SH3_1 PF00018.23 ESA10293.1 - 7.7e-13 47.6 0.4 1.3e-12 46.9 0.3 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA10293.1 - 6.7e-10 38.3 0.2 1.1e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA10293.1 - 2.5e-07 30.0 0.2 5e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Sec63 PF02889.11 ESA10294.1 - 4.6e-65 219.8 0.0 1.8e-63 214.6 0.0 2.1 1 1 0 1 1 1 1 Sec63 Brl domain Pkinase_Tyr PF07714.12 ESA10295.1 - 4.4e-51 173.4 0.0 6.7e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10295.1 - 1.4e-48 165.3 0.1 2.2e-48 164.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA10295.1 - 7.3e-12 45.5 13.6 4e-05 24.1 0.1 3.8 3 1 0 3 3 3 2 Sel1 repeat YrbL-PhoP_reg PF10707.4 ESA10295.1 - 0.00033 20.0 0.1 0.00076 18.8 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA10295.1 - 0.0087 15.1 0.1 0.023 13.7 0.0 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.11 ESA10295.1 - 0.01 15.8 0.0 0.041 13.8 0.0 2.0 1 0 0 1 1 1 0 ABC1 family Kinase-like PF14531.1 ESA10295.1 - 0.034 13.1 0.0 0.06 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA10295.1 - 0.068 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF202 PF02656.10 ESA10296.1 - 9.1e-14 51.4 3.0 9.1e-14 51.4 2.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF2615 PF11027.3 ESA10296.1 - 0.16 11.9 0.1 0.25 11.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) 7TMR-DISM_7TM PF07695.6 ESA10296.1 - 0.18 11.4 5.5 0.32 10.6 3.8 1.5 1 1 0 1 1 1 0 7TM diverse intracellular signalling Tom37 PF10568.4 ESA10297.1 - 1.7e-06 28.1 0.0 3.5e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.1 ESA10297.1 - 6.1e-06 26.0 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA10297.1 - 2.1e-05 24.9 0.0 3.6e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37_C PF11801.3 ESA10297.1 - 0.0041 17.0 0.3 0.19 11.6 0.0 2.3 1 1 0 2 2 2 1 Tom37 C-terminal domain Glycos_transf_1 PF00534.15 ESA10298.1 - 2.8e-24 85.4 0.4 1.7e-23 82.8 0.0 2.4 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESA10298.1 - 6.3e-08 32.8 0.0 1.4e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESA10298.1 - 2.9e-07 30.6 0.0 7.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 SAS4 PF15460.1 ESA10299.1 - 2.5e-08 33.6 3.5 2.5e-08 33.6 2.4 2.0 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 PEHE PF15275.1 ESA10299.1 - 0.00027 21.3 0.9 0.00027 21.3 0.6 2.8 2 1 0 2 2 2 1 PEHE domain Methyltransf_16 PF10294.4 ESA10300.1 - 3.9e-20 72.0 0.2 8.1e-16 57.9 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase GidB PF02527.10 ESA10300.1 - 0.0075 15.4 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G zf-C3HC4_2 PF13923.1 ESA10301.1 - 2.5e-10 40.2 9.0 4e-10 39.5 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA10301.1 - 2.5e-10 39.8 7.9 4.1e-10 39.1 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA10301.1 - 1.1e-09 37.9 9.8 1.9e-09 37.1 6.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESA10301.1 - 2e-08 33.7 6.6 3.2e-08 33.1 4.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA10301.1 - 1e-07 31.5 6.9 1.5e-07 30.9 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA10301.1 - 3.2e-06 26.7 2.3 3.2e-06 26.7 1.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA10301.1 - 9.2e-06 25.4 9.8 1.6e-05 24.6 6.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.6 ESA10301.1 - 8.4e-05 22.3 3.0 0.00013 21.6 2.1 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-Apc11 PF12861.2 ESA10301.1 - 0.00047 19.9 4.1 0.00079 19.2 2.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESA10301.1 - 0.0013 18.7 6.2 0.0023 18.0 4.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_4 PF14570.1 ESA10301.1 - 0.085 12.4 5.2 0.19 11.3 3.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.7 ESA10301.1 - 0.96 8.5 5.9 0.11 11.7 0.3 1.8 1 1 1 2 2 2 0 Rtf2 RING-finger JAB PF01398.16 ESA10302.1 - 5.9e-13 48.5 1.5 1.4e-12 47.3 0.1 2.1 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 ESA10302.1 - 5.2e-08 32.4 0.0 9.4e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF1506 PF07405.6 ESA10302.1 - 0.0085 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1506) DUF2775 PF10950.3 ESA10302.1 - 0.12 12.5 3.6 0.33 11.1 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2775) RTX_C PF08339.5 ESA10302.1 - 0.37 10.4 8.3 0.5 10.0 4.4 2.1 1 1 1 2 2 2 0 RTX C-terminal domain GAS PF13851.1 ESA10303.1 - 8.4e-05 21.8 9.5 8.4e-05 21.8 6.6 1.5 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding PspA_IM30 PF04012.7 ESA10303.1 - 0.0013 18.1 9.0 0.036 13.4 1.3 2.1 1 1 0 2 2 2 2 PspA/IM30 family Fib_alpha PF08702.5 ESA10303.1 - 0.0021 18.2 6.7 0.0021 18.2 4.6 1.4 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family FliJ PF02050.11 ESA10303.1 - 0.0028 17.6 9.8 0.0033 17.4 6.8 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein bZIP_1 PF00170.16 ESA10303.1 - 0.0038 17.1 8.2 0.052 13.4 2.0 2.4 2 0 0 2 2 2 1 bZIP transcription factor SlyX PF04102.7 ESA10303.1 - 0.0052 17.1 4.5 0.0052 17.1 3.1 2.5 1 1 1 2 2 2 1 SlyX IncA PF04156.9 ESA10303.1 - 0.0071 15.9 19.1 0.092 12.3 13.0 2.0 1 1 0 1 1 1 1 IncA protein AAA_13 PF13166.1 ESA10303.1 - 0.0079 14.7 7.1 0.0089 14.5 4.9 1.1 1 0 0 1 1 1 1 AAA domain Snapin_Pallidin PF14712.1 ESA10303.1 - 0.0093 16.2 4.8 0.017 15.3 3.3 1.4 1 0 0 1 1 1 1 Snapin/Pallidin TPR_MLP1_2 PF07926.7 ESA10303.1 - 0.011 15.4 12.6 0.013 15.2 8.7 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF812 PF05667.6 ESA10303.1 - 0.011 14.2 7.1 0.012 14.1 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Glutaredoxin2_C PF04399.8 ESA10303.1 - 0.012 15.2 4.3 0.13 11.7 0.1 2.1 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain Tropomyosin PF00261.15 ESA10303.1 - 0.022 13.8 13.1 0.025 13.6 9.0 1.1 1 0 0 1 1 1 0 Tropomyosin Rootletin PF15035.1 ESA10303.1 - 0.026 14.5 11.4 1.2 9.1 0.2 2.0 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FliD_C PF07195.7 ESA10303.1 - 0.036 13.3 3.6 0.049 12.9 2.5 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Gp58 PF07902.6 ESA10303.1 - 0.041 12.0 1.6 0.048 11.8 1.1 1.0 1 0 0 1 1 1 0 gp58-like protein Atg14 PF10186.4 ESA10303.1 - 0.044 12.7 9.6 0.049 12.5 6.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Cortex-I_coil PF09304.5 ESA10303.1 - 0.044 13.8 10.3 0.14 12.2 7.1 1.8 1 1 0 1 1 1 0 Cortexillin I, coiled coil TMF_DNA_bd PF12329.3 ESA10303.1 - 0.049 13.4 18.1 0.02 14.6 5.1 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding MscS_porin PF12795.2 ESA10303.1 - 0.06 12.6 10.8 0.13 11.5 7.5 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain TBPIP PF07106.8 ESA10303.1 - 0.065 12.7 12.0 0.31 10.5 7.9 1.9 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DASH_Duo1 PF08651.5 ESA10303.1 - 0.066 12.7 1.7 0.14 11.7 0.2 2.0 2 0 0 2 2 2 0 DASH complex subunit Duo1 SKIP_SNW PF02731.10 ESA10303.1 - 0.071 12.5 4.4 0.078 12.4 2.4 1.5 1 1 1 2 2 2 0 SKIP/SNW domain Spc7 PF08317.6 ESA10303.1 - 0.08 11.5 9.9 0.089 11.4 6.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Mitofilin PF09731.4 ESA10303.1 - 0.092 11.3 7.7 0.11 11.1 5.4 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein BLOC1_2 PF10046.4 ESA10303.1 - 0.094 12.8 9.2 0.2 11.8 1.6 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AbiH PF14253.1 ESA10303.1 - 0.12 11.9 5.9 0.14 11.7 4.1 1.1 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH ATG16 PF08614.6 ESA10303.1 - 0.12 12.2 12.0 0.25 11.1 8.3 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF506 PF04720.7 ESA10303.1 - 0.12 11.9 3.4 0.14 11.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF506) HAUS-augmin3 PF14932.1 ESA10303.1 - 0.12 11.5 8.6 0.43 9.7 6.0 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.3 ESA10303.1 - 0.13 12.1 12.5 0.52 10.2 2.7 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF342 PF03961.8 ESA10303.1 - 0.13 10.6 9.1 0.16 10.3 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF745 PF05335.8 ESA10303.1 - 0.14 11.6 1.4 0.16 11.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) APG6 PF04111.7 ESA10303.1 - 0.17 10.8 12.5 0.19 10.7 8.6 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1664 PF07889.7 ESA10303.1 - 0.18 11.6 4.2 0.65 9.7 2.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Syntaxin-18_N PF10496.4 ESA10303.1 - 0.2 11.4 2.1 0.61 9.9 1.4 1.9 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Plant_NMP1 PF06694.6 ESA10303.1 - 0.22 10.4 4.3 0.47 9.3 0.2 2.0 1 1 1 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) DnaG_DnaB_bind PF08278.6 ESA10303.1 - 0.22 11.7 8.5 0.66 10.1 5.9 1.8 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding Phage_GPO PF05929.6 ESA10303.1 - 0.3 10.2 3.1 0.39 9.9 2.2 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Tautomerase_2 PF14552.1 ESA10303.1 - 0.36 10.8 2.8 0.16 12.0 0.4 1.6 2 0 0 2 2 1 0 Tautomerase enzyme DUF4298 PF14131.1 ESA10303.1 - 0.38 10.6 5.7 5.5 6.9 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) LMP PF04778.7 ESA10303.1 - 0.38 10.4 6.4 0.45 10.2 4.5 1.2 1 0 0 1 1 1 0 LMP repeated region CENP-Q PF13094.1 ESA10303.1 - 0.43 10.5 16.8 0.88 9.5 8.4 2.0 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit OmpH PF03938.9 ESA10303.1 - 0.51 10.2 8.1 0.67 9.8 5.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tropomyosin_1 PF12718.2 ESA10303.1 - 0.54 10.1 17.0 0.039 13.8 4.2 2.0 1 1 0 1 1 1 0 Tropomyosin like FlaC_arch PF05377.6 ESA10303.1 - 0.54 10.1 7.3 7.5 6.5 0.1 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) CtIP_N PF10482.4 ESA10303.1 - 0.62 9.8 9.1 1.4 8.7 6.3 1.6 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Mgr1 PF08602.5 ESA10303.1 - 0.62 9.0 4.8 0.66 8.9 3.3 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit V_ATPase_I PF01496.14 ESA10303.1 - 0.77 7.5 8.6 0.83 7.4 6.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spectrin PF00435.16 ESA10303.1 - 0.79 10.0 8.4 0.71 10.1 0.9 2.1 1 1 1 2 2 2 0 Spectrin repeat DUF641 PF04859.7 ESA10303.1 - 0.87 9.3 10.2 2.8 7.6 5.8 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.1 ESA10303.1 - 0.95 8.3 4.9 1.1 8.2 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3552 PF12072.3 ESA10303.1 - 1.1 8.4 16.7 3.2 6.9 10.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Hpt PF01627.18 ESA10303.1 - 1.2 9.1 4.7 36 4.4 3.3 2.5 1 1 0 1 1 1 0 Hpt domain DUF3340 PF11818.3 ESA10303.1 - 1.2 9.0 11.4 0.093 12.6 3.5 1.9 1 1 1 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) TcdB_N PF12918.2 ESA10303.1 - 1.3 9.1 5.9 0.71 9.9 2.0 2.1 1 1 0 1 1 1 0 TcdB toxin N-terminal helical domain Sipho_Gp157 PF05565.6 ESA10303.1 - 1.4 8.4 10.3 0.27 10.7 1.1 2.2 1 1 1 2 2 2 0 Siphovirus Gp157 Syntaxin-6_N PF09177.6 ESA10303.1 - 1.6 9.1 8.9 12 6.4 6.2 2.3 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TMPIT PF07851.8 ESA10303.1 - 1.7 7.6 4.3 2.1 7.3 3.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein Matrilin_ccoil PF10393.4 ESA10303.1 - 1.7 8.0 8.7 14 5.0 0.0 3.6 3 1 1 4 4 3 0 Trimeric coiled-coil oligomerisation domain of matrilin SbcD_C PF12320.3 ESA10303.1 - 1.8 8.6 8.1 0.71 9.9 2.2 2.2 1 1 1 2 2 2 0 Type 5 capsule protein repressor C-terminal domain BRE1 PF08647.6 ESA10303.1 - 2 8.4 10.4 0.43 10.5 2.8 2.1 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Prefoldin_2 PF01920.15 ESA10303.1 - 2.1 8.1 13.8 0.4 10.4 1.2 2.5 1 1 0 2 2 2 0 Prefoldin subunit Val_tRNA-synt_C PF10458.4 ESA10303.1 - 2.4 8.2 7.1 24 5.1 0.3 3.1 1 1 3 4 4 4 0 Valyl tRNA synthetase tRNA binding arm FlxA PF14282.1 ESA10303.1 - 2.5 8.0 10.1 0.76 9.7 1.6 2.4 1 1 1 2 2 2 0 FlxA-like protein CENP-F_leu_zip PF10473.4 ESA10303.1 - 2.7 7.8 16.6 4 7.3 11.2 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BTV_NS2 PF04514.7 ESA10303.1 - 4.5 6.0 9.9 4.8 5.9 6.8 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CASP_C PF08172.7 ESA10303.1 - 4.6 6.1 12.6 2 7.3 1.8 2.1 1 1 1 2 2 2 0 CASP C terminal DUF972 PF06156.8 ESA10303.1 - 4.6 7.6 10.4 1.4 9.2 3.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) COG2 PF06148.6 ESA10303.1 - 4.7 7.0 8.1 35 4.2 5.6 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Prefoldin PF02996.12 ESA10303.1 - 5.1 6.7 10.2 3.4 7.3 0.4 2.4 1 1 1 2 2 2 0 Prefoldin subunit zf-C4H2 PF10146.4 ESA10303.1 - 5.6 6.9 12.7 17 5.3 8.8 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Nup54 PF13874.1 ESA10303.1 - 5.9 6.5 9.5 21 4.7 6.6 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF1700 PF08006.6 ESA10303.1 - 6.1 6.1 6.1 5.2 6.3 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) DUF4446 PF14584.1 ESA10303.1 - 7 6.4 6.8 12 5.6 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF3498 PF12004.3 ESA10303.1 - 8.8 5.3 14.8 10 5.1 10.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) Tho2 PF11262.3 ESA10303.1 - 8.9 5.2 7.3 15 4.5 4.5 1.7 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Macoilin PF09726.4 ESA10303.1 - 9.8 4.3 12.5 10 4.2 8.6 1.1 1 0 0 1 1 1 0 Transmembrane protein RNA_binding PF01877.12 ESA10304.1 - 0.058 13.4 8.4 0.18 11.8 0.3 2.2 1 1 1 2 2 2 0 RNA binding DUF2089 PF09862.4 ESA10304.1 - 0.12 12.1 4.9 0.2 11.4 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2089) CALCOCO1 PF07888.6 ESA10304.1 - 0.14 10.4 18.5 0.16 10.2 12.8 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like YjcZ PF13990.1 ESA10304.1 - 0.19 10.8 6.5 0.21 10.6 3.7 1.6 1 1 1 2 2 2 0 YjcZ-like protein KxDL PF10241.4 ESA10304.1 - 0.28 11.0 5.5 0.43 10.5 3.6 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein TPR_MLP1_2 PF07926.7 ESA10304.1 - 0.38 10.5 21.1 2.2 8.0 14.6 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Ly49 PF08391.5 ESA10304.1 - 0.55 10.3 7.6 0.13 12.3 2.4 1.9 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Sec2p PF06428.6 ESA10304.1 - 1.1 9.1 20.1 1.9 8.4 2.1 2.9 1 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF2052 PF09747.4 ESA10304.1 - 1.3 8.9 14.4 1.6 8.6 10.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4559 PF15112.1 ESA10304.1 - 1.3 8.1 12.9 1.7 7.7 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF2968 PF11180.3 ESA10304.1 - 1.3 8.3 15.5 4.6 6.5 8.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Cortex-I_coil PF09304.5 ESA10304.1 - 1.4 9.0 19.7 11 6.0 8.6 2.3 1 1 1 2 2 2 0 Cortexillin I, coiled coil DASH_Hsk3 PF08227.6 ESA10304.1 - 1.6 9.0 4.2 2.1 8.6 0.1 2.8 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like DUF948 PF06103.6 ESA10304.1 - 1.8 8.4 8.2 4.9 7.0 3.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) SUV3_C PF12513.3 ESA10304.1 - 2.1 7.8 4.4 22 4.6 0.5 2.6 1 1 1 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal DUF745 PF05335.8 ESA10304.1 - 2.4 7.6 12.1 1.8 8.0 6.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF4200 PF13863.1 ESA10304.1 - 2.7 7.9 26.0 0.43 10.5 5.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.7 ESA10304.1 - 3.4 7.4 10.2 2.1 8.1 3.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 ESA10304.1 - 3.6 6.4 18.4 5.9 5.7 12.8 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4363 PF14276.1 ESA10304.1 - 4 7.1 9.3 0.95 9.1 1.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) UPF0242 PF06785.6 ESA10304.1 - 5.3 5.6 14.1 8.9 4.8 9.8 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) Borrelia_P83 PF05262.6 ESA10304.1 - 6.1 5.0 14.9 7.4 4.7 10.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein HSP70 PF00012.15 ESA10304.1 - 6.8 4.4 13.8 8.5 4.1 9.6 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF4600 PF15372.1 ESA10304.1 - 6.8 6.9 19.5 40 4.4 13.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) DUF4404 PF14357.1 ESA10304.1 - 7.7 7.0 15.9 0.77 10.2 4.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF87 PF01935.12 ESA10304.1 - 8.5 6.1 10.8 26 4.5 7.1 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF87 IncA PF04156.9 ESA10304.1 - 9.4 5.7 20.1 4.1 6.9 11.3 1.6 1 1 0 1 1 1 0 IncA protein DUF4097 PF13349.1 ESA10305.1 - 0.67 9.4 7.3 4.6 6.7 3.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4097) PseudoU_synth_1 PF01416.15 ESA10306.1 - 0.027 14.9 0.0 0.049 14.0 0.0 1.4 1 1 0 1 1 1 0 tRNA pseudouridine synthase DUF106 PF01956.11 ESA10306.1 - 0.033 13.7 0.1 0.037 13.5 0.0 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF106 Virul_fac_BrkB PF03631.10 ESA10306.1 - 0.058 12.7 0.1 0.07 12.4 0.1 1.1 1 0 0 1 1 1 0 Virulence factor BrkB Apis_Csd PF11671.3 ESA10308.1 - 0.04 13.7 0.1 0.046 13.5 0.1 1.1 1 0 0 1 1 1 0 Complementary sex determiner protein NmrA PF05368.8 ESA10310.1 - 4.2e-28 98.1 0.1 4.7e-28 98.0 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA10310.1 - 9.6e-10 38.7 0.0 1.3e-09 38.2 0.0 1.3 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 ESA10310.1 - 7.6e-07 29.1 0.0 1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA10310.1 - 2.2e-06 27.4 0.0 3.2e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESA10310.1 - 5.4e-05 22.7 0.0 8.5e-05 22.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA10310.1 - 0.00024 19.9 0.0 0.00037 19.3 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.13 ESA10310.1 - 0.00083 19.3 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 TrkA-N domain Saccharop_dh PF03435.13 ESA10310.1 - 0.0022 17.0 0.1 0.0028 16.6 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase DapB_N PF01113.15 ESA10310.1 - 0.0098 15.8 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 ESA10310.1 - 0.063 13.7 0.0 0.096 13.1 0.0 1.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Ribosomal_L28 PF00830.14 ESA10311.1 - 0.11 12.3 0.1 1.2 9.0 0.0 2.8 3 1 0 3 3 3 0 Ribosomal L28 family G10 PF01125.12 ESA10314.1 - 0.065 12.7 0.1 0.28 10.7 0.0 2.0 2 0 0 2 2 2 0 G10 protein SAM_1 PF00536.25 ESA10315.1 - 0.073 13.2 1.0 0.17 12.0 0.0 2.1 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) BACK PF07707.10 ESA10320.1 - 1.4e-11 44.1 3.0 2.5e-08 33.7 0.2 4.1 3 2 0 4 4 4 2 BTB And C-terminal Kelch BTB PF00651.26 ESA10320.1 - 3.1e-08 33.5 0.2 7.4e-08 32.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Bcl-2 PF00452.14 ESA10320.1 - 0.021 14.9 0.1 0.21 11.7 0.1 2.5 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Urm1 PF09138.6 ESA10320.1 - 0.052 13.6 0.2 0.19 11.8 0.1 2.0 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) DUF2796 PF10986.3 ESA10320.1 - 0.068 13.1 0.3 0.099 12.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Armet PF10208.4 ESA10322.1 - 0.035 13.7 0.0 0.038 13.6 0.0 1.1 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding Nefa_Nip30_N PF10187.4 ESA10324.1 - 2.4e-05 24.4 10.4 0.0095 16.0 1.8 3.2 2 1 1 3 3 3 2 N-terminal domain of NEFA-interacting nuclear protein NIP30 Geminin PF07412.7 ESA10324.1 - 0.0013 18.4 6.7 0.017 14.8 0.2 3.0 1 1 2 3 3 3 2 Geminin COG4 PF08318.7 ESA10326.1 - 0.051 12.3 0.0 0.057 12.1 0.0 1.0 1 0 0 1 1 1 0 COG4 transport protein Presenilin PF01080.12 ESA10327.1 - 0.4 9.4 2.2 0.43 9.3 1.5 1.1 1 0 0 1 1 1 0 Presenilin Myf5 PF12232.3 ESA10327.1 - 0.85 10.2 6.3 0.23 12.0 1.7 1.9 2 0 0 2 2 2 0 Myogenic determination factor 5 CRM1_C PF08767.6 ESA10328.1 - 2.3e-131 437.4 8.7 2.7e-131 437.2 6.0 1.0 1 0 0 1 1 1 1 CRM1 C terminal BID PF06393.6 ESA10328.1 - 0.027 13.8 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 BH3 interacting domain (BID) Symplekin_C PF12295.3 ESA10328.1 - 0.042 13.7 0.6 0.24 11.2 0.0 2.4 2 1 1 3 3 3 0 Symplekin tight junction protein C terminal Spo7 PF03907.8 ESA10329.1 - 4.6e-19 68.8 4.1 5.8e-19 68.5 2.8 1.1 1 0 0 1 1 1 1 Spo7-like protein Tmemb_18A PF09771.4 ESA10329.1 - 0.00025 21.0 0.3 0.00036 20.5 0.2 1.3 1 0 0 1 1 1 1 Transmembrane protein 188 DUF3671 PF12420.3 ESA10329.1 - 0.03 14.2 1.0 0.03 14.2 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function Metal_resist PF13801.1 ESA10330.1 - 0.24 11.4 4.8 0.29 11.1 3.3 1.2 1 0 0 1 1 1 0 Heavy-metal resistance Sel1 PF08238.7 ESA10331.1 - 3.8e-34 116.3 8.2 5.6e-13 49.0 0.5 3.5 4 0 0 4 4 4 3 Sel1 repeat MIT PF04212.13 ESA10331.1 - 0.0076 16.1 6.2 2.6 7.9 0.0 3.3 2 1 1 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA10331.1 - 0.031 14.7 1.9 3.3 8.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10331.1 - 1.3 8.7 9.7 2.9 7.6 3.0 3.0 1 1 2 3 3 3 0 TPR repeat TPR_1 PF00515.23 ESA10331.1 - 3.7 7.3 14.5 15 5.4 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA10331.1 - 8.4 6.5 15.7 18 5.5 0.0 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF4621 PF15414.1 ESA10332.1 - 0.09 11.4 0.3 0.1 11.2 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4621) DUF3794 PF12673.2 ESA10333.1 - 0.047 13.8 0.3 0.068 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) HbrB PF08539.6 ESA10333.1 - 0.18 11.6 1.7 0.17 11.7 0.6 1.5 1 1 0 1 1 1 0 HbrB-like DUF4269 PF14091.1 ESA10334.1 - 0.011 15.6 0.9 0.018 14.9 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4269) bZIP_1 PF00170.16 ESA10335.1 - 0.0011 18.8 2.6 0.0011 18.8 1.8 2.0 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.10 ESA10335.1 - 0.023 14.4 4.6 0.023 14.4 3.2 2.2 2 0 0 2 2 2 0 Basic region leucine zipper HI0933_like PF03486.9 ESA10335.1 - 0.17 10.2 1.1 0.24 9.8 0.8 1.1 1 0 0 1 1 1 0 HI0933-like protein WD40 PF00400.27 ESA10336.1 - 0.00036 20.2 1.1 0.005 16.6 0.0 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 ESA10336.1 - 0.046 12.5 0.0 7 5.3 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region Lactonase PF10282.4 ESA10336.1 - 0.074 12.1 0.1 0.16 10.9 0.0 1.6 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Fer2_3 PF13085.1 ESA10337.1 - 8.8e-33 112.4 0.5 2.7e-32 110.8 0.1 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 ESA10337.1 - 1.3e-09 38.2 5.9 1.3e-09 38.2 4.1 2.1 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESA10337.1 - 9.5e-09 35.1 4.4 9.5e-09 35.1 3.1 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESA10337.1 - 0.00012 22.2 6.6 0.024 14.8 0.6 3.2 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_18 PF13746.1 ESA10337.1 - 0.00021 21.6 1.6 0.00021 21.6 1.1 2.8 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 ESA10337.1 - 0.00049 19.8 5.3 0.00049 19.8 3.7 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 ESA10337.1 - 0.0048 17.2 6.1 0.0048 17.2 4.2 2.6 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 ESA10337.1 - 0.0064 16.2 6.2 0.0096 15.6 1.4 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DUF3688 PF12461.3 ESA10337.1 - 0.065 13.6 0.4 1.5 9.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3688) HTH_Tnp_IS1 PF12759.2 ESA10337.1 - 0.078 12.4 0.8 0.22 10.9 0.6 1.7 1 0 0 1 1 1 0 InsA C-terminal domain Fer4_15 PF13459.1 ESA10337.1 - 0.7 10.5 6.9 1 9.9 0.1 2.8 3 0 0 3 3 2 0 4Fe-4S single cluster domain Fer4_16 PF13484.1 ESA10337.1 - 9.7 7.0 14.2 10 6.9 0.4 3.8 3 1 0 3 3 3 0 4Fe-4S double cluster binding domain Transposase_22 PF02994.9 ESA10338.1 - 0.0091 14.5 2.3 0.016 13.7 1.6 1.4 1 0 0 1 1 1 1 L1 transposable element FlxA PF14282.1 ESA10338.1 - 0.01 15.7 2.0 0.023 14.6 1.4 1.6 1 0 0 1 1 1 0 FlxA-like protein Plasmid_parti PF01672.11 ESA10340.1 - 0.15 12.5 1.0 0.16 12.4 0.7 1.1 1 0 0 1 1 1 0 Putative plasmid partition protein RIC1 PF07064.8 ESA10341.1 - 5.4e-68 229.2 1.5 8.5e-68 228.5 1.0 1.3 1 0 0 1 1 1 1 RIC1 WD40 PF00400.27 ESA10341.1 - 0.22 11.4 5.5 2.9 7.9 0.6 4.7 5 0 0 5 5 5 0 WD domain, G-beta repeat zf-RVT PF13966.1 ESA10342.1 - 0.0011 19.2 0.2 0.0066 16.7 0.0 2.3 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase BTB PF00651.26 ESA10343.1 - 3.8e-09 36.5 1.5 2.9e-08 33.6 0.1 2.3 2 1 1 3 3 3 1 BTB/POZ domain Bcl-2 PF00452.14 ESA10343.1 - 0.032 14.3 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Urm1 PF09138.6 ESA10343.1 - 0.053 13.6 0.5 0.08 13.0 0.1 1.6 2 0 0 2 2 2 0 Urm1 (Ubiquitin related modifier) DUF2421 PF10334.4 ESA10343.1 - 0.12 11.9 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2421) BACK PF07707.10 ESA10344.1 - 0.012 15.4 1.0 0.8 9.5 0.1 2.9 2 1 0 2 2 2 0 BTB And C-terminal Kelch BTB PF00651.26 ESA10345.1 - 5.8e-15 55.2 0.4 1.4e-14 53.9 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain Glyco_hydro_9 PF00759.14 ESA10346.1 - 4.3e-14 52.2 0.3 4.9e-14 52.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 DUF1042 PF06294.6 ESA10350.1 - 0.062 12.8 0.1 0.085 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1042) DUF4448 PF14610.1 ESA10351.1 - 0.001 18.6 0.4 0.001 18.6 0.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF4448) BNIP3 PF06553.7 ESA10351.1 - 0.65 9.3 0.1 0.65 9.3 0.0 2.7 2 1 1 3 3 3 0 BNIP3 CDC45 PF02724.9 ESA10352.1 - 0.00036 18.7 19.2 0.00064 17.8 13.3 1.4 1 0 0 1 1 1 1 CDC45-like protein Daxx PF03344.10 ESA10352.1 - 0.0035 15.9 31.6 0.006 15.1 21.9 1.3 1 0 0 1 1 1 1 Daxx Family Nop14 PF04147.7 ESA10352.1 - 0.04 11.8 37.9 0.013 13.4 24.4 1.5 2 0 0 2 2 2 0 Nop14-like family Paf1 PF03985.8 ESA10352.1 - 0.11 11.2 31.8 0.19 10.4 22.0 1.4 1 0 0 1 1 1 0 Paf1 CENP-T PF15511.1 ESA10352.1 - 0.16 11.1 23.0 0.27 10.4 15.9 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Astro_capsid PF03115.9 ESA10352.1 - 2.5 6.2 14.1 4.3 5.4 9.8 1.3 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Spore_coat_CotO PF14153.1 ESA10352.1 - 4.3 6.7 30.6 0.95 8.8 18.0 2.1 2 0 0 2 2 2 0 Spore coat protein CotO HTH_Tnp_Tc5 PF03221.11 ESA10354.1 - 3.3e-09 36.4 0.0 4.8e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA10354.1 - 0.00045 19.4 0.1 0.0021 17.2 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease Pkinase_Tyr PF07714.12 ESA10355.1 - 5.2e-16 58.5 0.0 7.3e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10355.1 - 2.4e-12 46.5 1.1 5.6e-12 45.3 0.8 1.5 1 1 0 1 1 1 1 Protein kinase domain BRAP2 PF07576.7 ESA10355.1 - 0.031 13.8 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 BRCA1-associated protein 2 zf-C2H2_jaz PF12171.3 ESA10355.1 - 4.8 7.4 6.9 14 5.9 0.1 3.5 2 2 1 3 3 3 0 Zinc-finger double-stranded RNA-binding Na_H_Exchanger PF00999.16 ESA10356.1 - 6.2e-39 133.5 20.2 7.8e-39 133.2 14.0 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF543 PF04418.7 ESA10356.1 - 0.072 13.0 0.4 0.57 10.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF543) CRISPR_Cas2 PF09827.4 ESA10359.1 - 0.017 15.2 1.5 0.58 10.3 0.2 2.6 2 0 0 2 2 2 0 CRISPR associated protein Cas2 Metallophos PF00149.23 ESA10361.1 - 1e-37 129.4 0.5 1.4e-37 129.0 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sec6 PF06046.8 ESA10362.1 - 6.9e-141 470.1 6.9 6.9e-141 470.1 4.8 1.8 2 0 0 2 2 2 1 Exocyst complex component Sec6 Vps53_N PF04100.7 ESA10362.1 - 0.00055 18.8 8.8 0.00055 18.8 6.1 2.4 1 1 0 2 2 2 1 Vps53-like, N-terminal GPAT_N PF14829.1 ESA10362.1 - 0.019 14.6 0.0 2.1 8.1 0.0 3.1 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal DUF3610 PF12272.3 ESA10362.1 - 0.16 11.6 3.6 2.4 7.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3610) FtsJ PF01728.14 ESA10363.1 - 7e-65 218.4 0.0 8.4e-65 218.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase RNA_pol_Rpb4 PF03874.11 ESA10364.1 - 5.1e-19 68.4 3.8 6.5e-19 68.0 2.6 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 HrpB2 PF09487.5 ESA10364.1 - 0.01 16.0 0.2 0.092 12.9 0.0 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB2) DALR_1 PF05746.10 ESA10364.1 - 0.019 14.8 1.7 0.028 14.3 1.1 1.4 1 1 0 1 1 1 0 DALR anticodon binding domain DUF445 PF04286.7 ESA10364.1 - 0.026 14.0 0.5 0.028 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Strep_67kDa_ant PF06100.6 ESA10364.1 - 0.12 10.7 0.1 0.13 10.5 0.1 1.0 1 0 0 1 1 1 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family GP41 PF00517.12 ESA10365.1 - 0.12 11.9 0.3 0.16 11.4 0.2 1.2 1 0 0 1 1 1 0 Retroviral envelope protein F-box-like PF12937.2 ESA10366.1 - 5.9e-05 22.7 0.7 5.9e-05 22.7 0.5 2.1 3 0 0 3 3 3 1 F-box-like Erf4 PF10256.4 ESA10366.1 - 0.05 13.4 1.5 0.086 12.7 0.2 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family Lipase_3 PF01764.20 ESA10369.1 - 8.7e-24 83.7 0.0 1.9e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA10369.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family GerE PF00196.14 ESA10370.1 - 2.2e-10 39.6 0.0 1.7e-08 33.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family FaeA PF04703.7 ESA10370.1 - 4.9e-06 26.6 0.1 8.8e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 FaeA-like protein Sigma70_r4_2 PF08281.7 ESA10370.1 - 0.0016 17.8 0.1 0.98 8.9 0.0 2.7 3 0 0 3 3 3 2 Sigma-70, region 4 DUF728 PF05304.7 ESA10370.1 - 0.013 15.6 0.2 0.032 14.3 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF728) MarR_2 PF12802.2 ESA10370.1 - 0.014 15.0 0.1 3.5 7.3 0.0 2.7 2 0 0 2 2 2 0 MarR family HTH_38 PF13936.1 ESA10370.1 - 0.097 12.2 0.4 1.6 8.3 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_Mga PF08280.6 ESA10370.1 - 0.15 11.8 1.2 34 4.3 0.0 3.3 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain Med11 PF10280.4 ESA10371.1 - 0.015 15.3 3.9 0.9 9.5 0.3 2.4 2 1 0 2 2 2 0 Mediator complex protein MIR PF02815.14 ESA10372.1 - 6.9e-05 22.4 0.8 0.075 12.5 0.0 2.8 2 1 1 3 3 3 2 MIR domain p450 PF00067.17 ESA10373.1 - 4e-32 111.3 0.0 4.4e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2457 PF10446.4 ESA10374.1 - 0.043 12.5 17.4 0.078 11.6 12.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) GPS PF01825.16 ESA10378.1 - 5.9e-05 23.0 10.8 0.032 14.3 0.2 4.6 4 0 0 4 4 4 3 Latrophilin/CL-1-like GPS domain RMMBL PF07521.7 ESA10378.1 - 0.056 13.2 0.0 29 4.5 0.0 3.2 3 0 0 3 3 3 0 RNA-metabolising metallo-beta-lactamase Fer4_8 PF13183.1 ESA10378.1 - 0.066 13.2 2.8 14 5.8 0.1 3.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain DUF2789 PF10982.3 ESA10379.1 - 0.088 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) Pkinase_Tyr PF07714.12 ESA10380.1 - 2.4e-30 105.4 0.0 2.4e-29 102.1 0.0 2.7 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10380.1 - 3.9e-27 95.0 1.3 1.9e-26 92.7 0.9 2.3 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA10380.1 - 1.6e-05 24.7 0.2 2.7e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1700 PF08006.6 ESA10380.1 - 0.0034 16.7 0.2 16 4.7 0.0 3.9 4 0 0 4 4 4 2 Protein of unknown function (DUF1700) BSD PF03909.12 ESA10382.1 - 5.2e-15 54.9 5.9 2.2e-14 52.9 0.1 3.1 3 0 0 3 3 3 1 BSD domain DUF3549 PF12069.3 ESA10382.1 - 0.014 14.1 0.4 0.014 14.1 0.3 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3549) Aminotran_1_2 PF00155.16 ESA10382.1 - 0.033 13.1 0.0 0.053 12.4 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II AIF_C PF14721.1 ESA10382.1 - 0.11 12.7 5.1 0.41 10.8 0.4 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FKBP_N PF01346.13 ESA10382.1 - 0.72 9.9 7.6 0.31 11.0 1.9 2.2 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase CCDC84 PF14968.1 ESA10382.1 - 1.4 8.3 8.4 0.27 10.6 2.1 1.9 2 0 0 2 2 2 0 Coiled coil protein 84 Syntaxin-6_N PF09177.6 ESA10383.1 - 8.4e-26 90.2 4.0 8.4e-26 90.2 2.8 2.3 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 ESA10383.1 - 2.4e-12 46.3 2.1 2.4e-12 46.3 1.5 3.4 3 1 2 5 5 5 1 SNARE domain TBPIP PF07106.8 ESA10383.1 - 0.002 17.6 4.7 0.002 17.6 3.3 2.2 1 1 0 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Atg14 PF10186.4 ESA10383.1 - 0.0073 15.2 2.2 0.0073 15.2 1.6 2.1 1 1 1 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 CsgE PF10627.4 ESA10383.1 - 0.029 14.1 0.3 0.1 12.4 0.0 2.1 2 0 0 2 2 2 0 Curli assembly protein CsgE Katanin_con80 PF13925.1 ESA10383.1 - 0.04 13.6 0.7 0.21 11.2 0.0 2.3 2 2 1 3 3 3 0 con80 domain of Katanin DUF745 PF05335.8 ESA10383.1 - 0.12 11.9 6.1 2.6 7.5 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF2019 PF09450.5 ESA10383.1 - 0.12 12.2 1.3 9.8 6.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2019) HAUS5 PF14817.1 ESA10383.1 - 0.2 10.1 12.3 0.36 9.3 3.9 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 5 Syntaxin PF00804.20 ESA10383.1 - 0.23 11.6 12.8 0.52 10.5 2.7 3.2 2 1 1 3 3 3 0 Syntaxin PTPA PF03095.10 ESA10383.1 - 0.9 8.6 3.7 0.49 9.5 0.2 1.9 1 1 1 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein Laminin_II PF06009.7 ESA10383.1 - 1.2 8.8 6.5 6 6.6 0.7 2.4 2 0 0 2 2 2 0 Laminin Domain II DUF2203 PF09969.4 ESA10383.1 - 4.2 7.6 8.0 8 6.7 0.7 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Allexi_40kDa PF05549.6 ESA10383.1 - 5.1 6.2 7.9 1.7 7.8 1.2 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF3377 PF11857.3 ESA10383.1 - 8 6.1 7.4 11 5.7 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Cauli_AT PF03233.8 ESA10383.1 - 8.7 6.0 8.8 0.98 9.1 1.0 2.2 2 0 0 2 2 2 0 Aphid transmission protein START PF01852.14 ESA10384.1 - 8.6e-26 90.5 0.1 1.3e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 START domain DUF3678 PF12435.3 ESA10384.1 - 0.78 9.3 13.1 6.9 6.3 8.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) MIR PF02815.14 ESA10385.1 - 0.00018 21.1 0.1 0.029 13.9 0.0 2.4 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA10385.1 - 0.03 13.3 0.0 0.058 12.4 0.0 1.5 1 1 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Ricin_B_lectin PF00652.17 ESA10385.1 - 0.044 13.8 0.7 0.09 12.8 0.4 1.6 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain Rhodanese PF00581.15 ESA10386.1 - 2.3e-07 31.1 0.0 5.2e-07 30.0 0.0 1.6 1 1 1 2 2 2 1 Rhodanese-like domain Dynactin_p62 PF05502.8 ESA10387.1 - 3e-87 293.4 22.6 4.3e-53 180.7 9.2 2.7 1 1 1 2 2 2 2 Dynactin p62 family zf-B_box PF00643.19 ESA10387.1 - 0.022 14.6 3.6 0.022 14.6 2.5 3.4 4 0 0 4 4 4 0 B-box zinc finger Vps51 PF08700.6 ESA10388.1 - 0.047 13.5 0.4 0.23 11.3 0.1 1.9 2 0 0 2 2 2 0 Vps51/Vps67 DUF643 PF04867.7 ESA10389.1 - 0.024 15.0 5.0 0.04 14.3 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF643) Pkinase_Tyr PF07714.12 ESA10390.1 - 2.6e-35 121.7 0.0 3.2e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10390.1 - 2.6e-35 121.8 0.0 3.5e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA10390.1 - 0.00021 21.1 0.4 0.0006 19.6 0.2 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA10390.1 - 0.00047 19.5 0.0 0.00069 19.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA10390.1 - 0.0024 16.9 0.0 0.0042 16.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA10390.1 - 0.0085 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Sel1 PF08238.7 ESA10392.1 - 1.2e-55 184.7 11.2 1.8e-12 47.4 0.1 6.0 6 0 0 6 6 6 6 Sel1 repeat Tox-HDC PF15656.1 ESA10392.1 - 0.11 12.6 1.2 12 6.1 0.1 2.4 2 0 0 2 2 2 0 Toxin with a H, D/N and C signature TPR_6 PF13174.1 ESA10392.1 - 0.72 10.4 3.9 28 5.4 0.1 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF3913 PF13052.1 ESA10392.1 - 0.99 9.3 3.8 15 5.5 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3913) zf-BED PF02892.10 ESA10393.1 - 3.7e-07 29.7 0.0 7.3e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.10 ESA10393.1 - 0.009 15.4 0.9 0.024 14.0 0.1 1.9 2 0 0 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.4 ESA10393.1 - 0.11 12.3 1.1 0.27 11.1 0.1 2.0 2 0 0 2 2 2 0 Zinc-finger domain Retrotrans_gag PF03732.12 ESA10394.1 - 2.1e-10 40.5 2.4 4.6e-10 39.4 1.6 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein UBN2 PF14223.1 ESA10394.1 - 0.00032 20.4 0.0 0.00088 19.0 0.0 1.8 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Gag_p24 PF00607.15 ESA10394.1 - 0.035 13.6 4.0 0.1 12.1 0.1 2.7 3 0 0 3 3 3 0 gag gene protein p24 (core nucleocapsid protein) Cytochrom_B562 PF07361.6 ESA10394.1 - 0.36 11.2 2.8 2.9 8.3 0.0 2.9 3 0 0 3 3 3 0 Cytochrome b562 AA_permease_2 PF13520.1 ESA10395.1 - 2.7e-30 105.2 28.9 3.1e-30 105.0 20.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA10395.1 - 1.5e-09 36.7 23.2 2e-09 36.3 16.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF423 PF04241.10 ESA10395.1 - 0.18 11.7 0.1 0.18 11.7 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF423) DUF4233 PF14017.1 ESA10395.1 - 0.32 10.9 5.4 0.57 10.1 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4233) Zip PF02535.17 ESA10397.1 - 0.45 9.4 1.9 0.71 8.8 1.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4477 PF14780.1 ESA10398.1 - 0.019 14.3 2.9 0.022 14.1 1.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4477) Ribosomal_L20 PF00453.13 ESA10398.1 - 0.035 14.0 3.9 1.7 8.5 0.3 2.8 1 1 1 2 2 2 0 Ribosomal protein L20 Apolipoprotein PF01442.13 ESA10398.1 - 0.12 11.9 7.9 0.06 12.8 2.6 2.1 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain ATP_bind_1 PF03029.12 ESA10398.1 - 0.19 11.2 2.3 0.29 10.6 1.0 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein S_layer_N PF05123.7 ESA10398.1 - 2.4 7.7 8.1 3.6 7.1 1.3 2.0 1 1 1 2 2 2 0 S-layer like family, N-terminal region RCC1 PF00415.13 ESA10399.1 - 8.8e-61 201.9 0.1 5.8e-12 45.6 0.0 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESA10399.1 - 3.7e-36 121.9 23.3 2.1e-09 36.7 0.1 8.0 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat SUKH-3 PF14433.1 ESA10399.1 - 0.14 11.9 1.6 25 4.6 0.0 3.4 4 0 0 4 4 4 0 SUKH-3 immunity protein DUF1406 PF07190.6 ESA10401.1 - 0.0077 15.9 2.2 0.49 10.0 0.1 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1406) DUF3548 PF12068.3 ESA10401.1 - 0.0084 15.4 0.4 0.23 10.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3548) BBS2_Mid PF14783.1 ESA10401.1 - 0.06 13.1 2.7 0.1 12.3 0.5 2.2 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region BCS1_N PF08740.6 ESA10401.1 - 0.09 12.3 0.2 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 BCS1 N terminal PA14_2 PF10528.4 ESA10401.1 - 0.092 12.7 0.7 0.7 9.8 0.1 2.3 2 0 0 2 2 2 0 GLEYA domain DUF2439 PF10382.4 ESA10401.1 - 0.33 11.2 6.3 0.53 10.5 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) DUF3316 PF11777.3 ESA10401.1 - 0.88 9.3 5.8 0.31 10.8 0.4 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF3316) Abhydrolase_6 PF12697.2 ESA10403.1 - 2.8e-31 109.1 0.0 6.6e-31 107.9 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA10403.1 - 9.7e-22 77.6 0.0 5.7e-21 75.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA10403.1 - 7.8e-16 58.1 0.0 3.4e-14 52.8 0.0 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESA10403.1 - 2.5e-06 27.2 0.0 0.011 15.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.15 ESA10403.1 - 4.9e-06 26.1 0.0 1e-05 25.1 0.0 1.6 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.3 ESA10403.1 - 0.00011 21.9 0.0 0.00023 20.9 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Ser_hydrolase PF06821.8 ESA10403.1 - 0.00045 19.8 0.0 0.0029 17.2 0.0 2.3 3 0 0 3 3 3 1 Serine hydrolase Lipase_3 PF01764.20 ESA10403.1 - 0.0013 18.3 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DLH PF01738.13 ESA10403.1 - 0.0018 17.6 0.0 0.24 10.6 0.0 2.5 3 0 0 3 3 3 1 Dienelactone hydrolase family DUF915 PF06028.6 ESA10403.1 - 0.0021 17.2 0.0 0.0041 16.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.15 ESA10403.1 - 0.0056 16.9 0.1 0.064 13.4 0.0 2.4 2 1 0 2 2 2 1 Thioesterase domain DUF2305 PF10230.4 ESA10403.1 - 0.0062 15.9 0.1 0.017 14.5 0.0 1.7 1 1 1 2 2 2 1 Uncharacterised conserved protein (DUF2305) Ndr PF03096.9 ESA10403.1 - 0.013 13.9 0.0 0.029 12.8 0.0 1.5 1 0 0 1 1 1 0 Ndr family PGAP1 PF07819.8 ESA10403.1 - 0.037 13.6 0.0 0.091 12.3 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein Peptidase_S9 PF00326.16 ESA10403.1 - 0.043 13.0 0.0 0.23 10.6 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 ESA10403.1 - 0.077 11.8 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Alpha_TIF PF02232.10 ESA10403.1 - 0.11 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha trans-inducing protein (Alpha-TIF) UPF0227 PF05728.7 ESA10403.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) F-box-like PF12937.2 ESA10405.1 - 0.00071 19.2 0.4 0.002 17.7 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA10405.1 - 0.021 14.4 0.3 0.12 12.0 0.0 2.5 2 0 0 2 2 2 0 F-box domain LRR_4 PF12799.2 ESA10405.1 - 4.6 6.9 8.8 5.8 6.6 0.4 3.9 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) MAPEG PF01124.13 ESA10406.1 - 1.8e-14 53.4 4.7 2.8e-14 52.8 3.3 1.3 1 0 0 1 1 1 1 MAPEG family DUF384 PF04064.8 ESA10408.1 - 0.15 11.6 0.1 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF384) PHO4 PF01384.15 ESA10409.1 - 2.2e-31 108.7 1.9 2.5e-31 108.5 1.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF2048 PF09752.4 ESA10409.1 - 0.057 12.2 0.6 0.07 12.0 0.4 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) DUF968 PF06147.6 ESA10410.1 - 0.36 10.7 7.2 0.11 12.3 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF968) DUF2986 PF11661.3 ESA10411.1 - 0.13 12.6 2.0 6.3 7.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2986) MitMem_reg PF13012.1 ESA10412.1 - 0.49 10.5 2.9 0.63 10.1 0.2 2.5 2 1 1 3 3 3 0 Maintenance of mitochondrial structure and function DUF3802 PF12290.3 ESA10416.1 - 0.11 12.7 0.1 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) Sel1 PF08238.7 ESA10419.1 - 1.6e-94 308.2 62.1 2.7e-12 46.8 1.6 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_17 PF13431.1 ESA10419.1 - 0.0085 16.2 32.0 9.7 6.6 0.7 9.5 8 1 0 9 9 9 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA10419.1 - 0.013 15.5 14.0 10 6.3 0.3 6.1 2 2 6 8 8 8 0 Tetratricopeptide repeat DUF4041 PF13250.1 ESA10419.1 - 0.073 12.6 7.7 35 4.0 0.1 5.6 3 1 3 6 6 6 0 Domain of unknown function (DUF4041) Surfac_D-trimer PF09006.6 ESA10419.1 - 0.18 11.5 22.2 49 3.7 0.0 8.5 6 3 3 9 9 9 0 Lung surfactant protein D coiled-coil trimerisation MIT PF04212.13 ESA10419.1 - 1.1 9.1 46.6 3.7 7.4 0.1 8.5 7 2 1 8 8 8 0 MIT (microtubule interacting and transport) domain DUF2666 PF10869.3 ESA10420.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) Pkinase PF00069.20 ESA10421.1 - 1.1e-58 198.4 0.0 1.6e-58 197.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10421.1 - 4.3e-51 173.4 0.0 5.3e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SAP PF02037.22 ESA10421.1 - 0.00043 19.7 0.0 0.0012 18.2 0.0 1.7 1 0 0 1 1 1 1 SAP domain DUF2222 PF09984.4 ESA10421.1 - 0.0038 16.6 0.3 0.0065 15.9 0.2 1.4 1 0 0 1 1 1 1 Uncharacterized signal transduction histidine kinase domain (DUF2222) F-box-like PF12937.2 ESA10422.1 - 0.0046 16.6 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 F-box-like DUF1473 PF07341.6 ESA10422.1 - 0.025 14.1 2.3 0.044 13.3 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1473) DUF4493 PF14900.1 ESA10422.1 - 0.03 13.9 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) F-box PF00646.28 ESA10422.1 - 0.05 13.2 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 F-box domain CBM_21 PF03370.8 ESA10422.1 - 0.053 13.5 1.9 0.19 11.7 0.5 2.3 2 1 0 2 2 2 0 Putative phosphatase regulatory subunit PUB PF09409.5 ESA10422.1 - 0.48 10.2 3.4 0.24 11.2 0.7 1.7 2 0 0 2 2 2 0 PUB domain tRNA-synt_1 PF00133.17 ESA10425.1 - 6.9e-125 417.3 0.9 8.4e-125 417.0 0.6 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESA10425.1 - 4.5e-09 35.4 0.6 0.00089 18.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 ESA10425.1 - 2.2e-06 27.1 0.0 3.4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.14 ESA10425.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 ESA10425.1 - 0.031 12.9 0.0 0.049 12.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_1b PF00579.20 ESA10425.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Ycf15 PF10705.4 ESA10425.1 - 0.23 11.5 2.1 0.3 11.1 0.0 2.2 2 0 0 2 2 2 0 Chloroplast protein precursor Ycf15 putative Pkinase_Tyr PF07714.12 ESA10426.1 - 8.1e-41 139.7 0.2 1.1e-40 139.3 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10426.1 - 1.6e-37 129.0 1.7 2.4e-37 128.5 1.2 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA10426.1 - 2.9e-06 26.7 0.7 8.6e-06 25.2 0.5 1.8 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA10426.1 - 0.00022 20.3 0.0 0.00035 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA10426.1 - 0.0038 16.2 0.0 0.01 14.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like DUF4168 PF13767.1 ESA10426.1 - 0.035 14.7 0.4 0.14 12.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4168) DUF2666 PF10869.3 ESA10426.1 - 3 7.8 12.6 1.3 9.0 2.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2666) Pkinase_Tyr PF07714.12 ESA10428.1 - 3.5e-36 124.5 0.0 4.3e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10428.1 - 5.2e-30 104.4 0.0 7.9e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA10428.1 - 0.0077 15.9 0.0 0.017 14.8 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA10428.1 - 0.054 12.4 0.0 0.091 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Abhydrolase_6 PF12697.2 ESA10429.1 - 2.7e-06 27.4 0.0 2.7e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family zf-MYND PF01753.13 ESA10430.1 - 1.1e-08 34.8 14.2 1.6e-08 34.2 9.9 1.3 1 0 0 1 1 1 1 MYND finger PolC_DP2 PF03833.8 ESA10430.1 - 1.3 6.6 3.9 1.6 6.3 2.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PLDc_N PF13396.1 ESA10432.1 - 1.1e-11 44.2 1.4 1.1e-11 44.2 1.0 1.3 1 1 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF1980 PF09323.5 ESA10432.1 - 0.0048 16.6 1.4 0.0049 16.6 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) 7TM_GPCR_Srj PF10319.4 ESA10432.1 - 0.33 10.0 4.9 0.32 10.0 3.4 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srj BTB_2 PF02214.17 ESA10434.1 - 5.7e-07 29.6 0.0 2.3e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 BTB/POZ domain DUF4305 PF14146.1 ESA10435.1 - 0.014 15.0 0.7 0.022 14.5 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4305) CorA PF01544.13 ESA10435.1 - 2.8 6.9 4.9 4.7 6.1 3.1 1.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Flu_M2 PF00599.12 ESA10436.1 - 0.058 13.1 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M2) VanZ PF04892.7 ESA10436.1 - 0.061 13.2 0.7 0.07 13.0 0.5 1.1 1 0 0 1 1 1 0 VanZ like family DUF2714 PF10896.3 ESA10436.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2714) Vanabin-2 PF11437.3 ESA10440.1 - 0.13 12.2 4.8 0.2 11.6 3.3 1.3 1 0 0 1 1 1 0 Vanadium-binding protein 2 DUF2207 PF09972.4 ESA10441.1 - 5.9 5.3 6.1 7.3 5.0 3.8 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CAP PF00188.21 ESA10442.1 - 1.5e-18 67.4 0.6 1.9e-18 67.1 0.4 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Viral_Hsp90 PF03225.9 ESA10442.1 - 0.0093 14.2 0.4 0.013 13.8 0.3 1.1 1 0 0 1 1 1 1 Viral heat shock protein Hsp90 homologue PRP38 PF03371.10 ESA10443.1 - 2.3e-60 203.1 0.5 2.5e-60 203.0 0.3 1.0 1 0 0 1 1 1 1 PRP38 family DUF4160 PF13711.1 ESA10444.1 - 0.022 14.5 0.2 0.023 14.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) Mob1_phocein PF03637.12 ESA10445.1 - 2.1e-78 261.9 0.5 2.5e-78 261.7 0.3 1.0 1 0 0 1 1 1 1 Mob1/phocein family Pkinase_Tyr PF07714.12 ESA10446.1 - 4.7e-09 35.7 0.1 4.9e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10446.1 - 3.2e-07 29.7 0.1 3.5e-07 29.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain OTCace_N PF02729.16 ESA10447.1 - 2.1e-44 150.6 0.0 3.2e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 ESA10447.1 - 1.5e-35 122.4 0.0 2.4e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Aldolase_II PF00596.16 ESA10448.1 - 1.7e-43 148.4 0.0 2.1e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Syja_N PF02383.13 ESA10448.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain ZZ PF00569.12 ESA10449.1 - 1.1e-16 60.1 28.2 5.4e-10 38.6 6.1 2.4 2 0 0 2 2 2 2 Zinc finger, ZZ type CtIP_N PF10482.4 ESA10449.1 - 0.013 15.2 3.6 0.026 14.3 2.3 1.7 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Cep57_MT_bd PF06657.8 ESA10449.1 - 0.028 14.3 2.5 3.1 7.8 0.2 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 TMF_TATA_bd PF12325.3 ESA10449.1 - 0.039 13.6 7.1 0.089 12.5 4.1 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding APG6 PF04111.7 ESA10449.1 - 0.043 12.8 3.2 0.055 12.5 2.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_2 PF07716.10 ESA10449.1 - 0.14 12.0 4.7 0.61 9.9 0.2 2.6 1 1 1 2 2 2 0 Basic region leucine zipper Uso1_p115_C PF04871.8 ESA10449.1 - 0.2 11.6 7.4 0.4 10.5 5.2 1.5 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fez1 PF06818.10 ESA10449.1 - 0.29 11.1 4.8 0.41 10.6 3.3 1.1 1 0 0 1 1 1 0 Fez1 FlaC_arch PF05377.6 ESA10449.1 - 0.4 10.6 5.2 12 5.8 0.1 3.1 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) ADIP PF11559.3 ESA10449.1 - 0.6 9.9 6.5 0.5 10.2 3.5 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding GAS PF13851.1 ESA10449.1 - 0.63 9.1 8.3 0.27 10.4 2.4 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIC PF04977.10 ESA10449.1 - 0.97 8.9 6.0 12 5.4 0.8 3.0 1 1 2 3 3 3 0 Septum formation initiator Kinesin-relat_1 PF12711.2 ESA10449.1 - 1.7 9.1 7.9 5.8 7.3 4.8 2.1 1 1 1 2 2 2 0 Kinesin motor DUF904 PF06005.7 ESA10449.1 - 2.6 8.3 6.5 8.8 6.6 4.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ESA10449.1 - 5.8 6.9 7.9 16 5.5 0.6 2.9 1 1 2 3 3 3 0 bZIP transcription factor TSC22 PF01166.13 ESA10449.1 - 8.4 6.4 8.7 3.8 7.5 0.1 3.1 3 0 0 3 3 3 0 TSC-22/dip/bun family BTB PF00651.26 ESA10451.1 - 8.5e-12 45.0 0.0 9.7e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Rep_fac-A_C PF08646.5 ESA10452.1 - 0.26 10.9 2.9 18 4.9 1.2 2.3 2 0 0 2 2 2 0 Replication factor-A C terminal domain Pkinase_Tyr PF07714.12 ESA10453.1 - 4.1e-20 71.9 0.2 7.2e-20 71.1 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10453.1 - 3.8e-17 62.3 0.7 5.9e-17 61.6 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-C3HC4_2 PF13923.1 ESA10456.1 - 0.0023 17.9 2.0 0.0044 17.0 0.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA10456.1 - 0.0047 16.7 1.0 0.0098 15.7 0.2 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 ESA10456.1 - 0.019 14.6 0.4 0.046 13.4 0.0 1.8 2 0 0 2 2 2 0 zinc-RING finger domain Rgp1 PF08737.5 ESA10456.1 - 0.021 13.8 5.3 0.026 13.6 3.7 1.1 1 0 0 1 1 1 0 Rgp1 zf-C3HC4 PF00097.20 ESA10456.1 - 0.036 13.7 0.5 0.036 13.7 0.4 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF448 PF04296.8 ESA10456.1 - 0.05 13.2 0.4 5.5 6.6 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF448) DUF327 PF03885.8 ESA10456.1 - 0.1 12.4 5.5 0.052 13.3 2.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF327) Afaf PF15339.1 ESA10456.1 - 0.88 9.1 7.4 1.6 8.3 5.1 1.6 1 1 0 1 1 1 0 Acrosome formation-associated factor Mre11_DNA_bind PF04152.9 ESA10456.1 - 4.9 6.9 9.3 2 8.2 2.2 2.6 2 1 0 3 3 3 0 Mre11 DNA-binding presumed domain VIT1 PF01988.14 ESA10458.1 - 2.8e-42 144.6 0.0 3.1e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 VIT family Kelch_4 PF13418.1 ESA10458.1 - 0.059 13.1 0.8 0.34 10.6 0.6 2.0 1 1 0 1 1 1 0 Galactose oxidase, central domain BTB PF00651.26 ESA10459.1 - 1.7e-10 40.8 0.3 4.9e-10 39.3 0.2 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA10459.1 - 3.9e-09 36.6 0.4 1e-08 35.2 0.3 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA10459.1 - 0.00029 20.6 0.8 0.00029 20.6 0.5 3.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA10459.1 - 0.004 16.3 0.7 0.0068 15.5 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Laminin_G_3 PF13385.1 ESA10460.1 - 9.3e-15 55.2 0.2 1.9e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA10460.1 - 8.2e-06 25.4 0.2 0.001 18.6 0.1 2.4 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA10460.1 - 0.00083 18.4 0.0 0.0014 17.6 0.0 1.4 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Laminin_G_3 PF13385.1 ESA10461.1 - 7e-16 58.8 0.0 1.6e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA10461.1 - 4.1e-08 32.9 0.9 0.00023 20.7 0.1 2.5 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA10461.1 - 1.3e-05 24.3 0.1 0.00051 19.1 0.0 2.3 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RicinB_lectin_2 PF14200.1 ESA10461.1 - 0.035 14.4 0.1 0.59 10.5 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like TPK_B1_binding PF04265.9 ESA10461.1 - 0.076 12.7 0.0 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, vitamin B1 binding domain HAUS-augmin3 PF14932.1 ESA10464.1 - 0.011 14.9 3.3 0.022 13.9 0.1 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4332 PF14229.1 ESA10464.1 - 0.17 11.8 1.1 0.3 11.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) DUF4615 PF15393.1 ESA10464.1 - 0.25 11.5 2.6 0.23 11.6 0.5 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4615) Peptidase_S9 PF00326.16 ESA10466.1 - 0.16 11.1 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family Pox_VP8_L4R PF04498.7 ESA10467.1 - 0.034 13.4 0.5 0.036 13.3 0.4 1.0 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R T2SG PF08334.6 ESA10467.1 - 0.043 13.5 0.0 0.05 13.3 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G DUF3993 PF13158.1 ESA10467.1 - 0.087 12.6 0.3 0.093 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3993) MULE PF10551.4 ESA10468.1 - 8.1e-07 29.1 0.2 1e-05 25.5 0.0 2.9 3 0 0 3 3 3 1 MULE transposase domain SWIM PF04434.12 ESA10468.1 - 0.015 14.7 0.6 0.033 13.6 0.4 1.5 1 0 0 1 1 1 0 SWIM zinc finger CAF1C_H4-bd PF12265.3 ESA10468.1 - 0.041 13.7 0.1 0.17 11.7 0.1 2.1 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex Pkinase_Tyr PF07714.12 ESA10469.1 - 2.3e-40 138.3 0.2 3.7e-40 137.6 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10469.1 - 9e-36 123.3 1.9 9e-36 123.3 1.3 1.5 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ESA10469.1 - 0.0033 16.4 0.0 0.0047 15.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Arch_ATPase PF01637.13 ESA10471.1 - 6.3e-10 39.1 0.4 1.2e-09 38.1 0.3 1.5 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA10471.1 - 4.1e-06 26.9 0.0 6.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA10471.1 - 0.00086 19.4 0.0 0.0019 18.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA10471.1 - 0.0086 15.9 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESA10471.1 - 0.02 14.8 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESA10471.1 - 0.037 13.1 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 ESA10471.1 - 0.045 13.3 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESA10471.1 - 0.071 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 ESA10471.1 - 0.078 12.9 0.1 0.22 11.5 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.1 ESA10471.1 - 0.1 12.3 0.0 0.29 10.9 0.0 1.7 2 0 0 2 2 2 0 Part of AAA domain Pkinase PF00069.20 ESA10473.1 - 4.3e-18 65.4 0.3 3.6e-16 59.0 0.2 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10473.1 - 5.3e-18 65.0 0.0 2.8e-16 59.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase F-box-like PF12937.2 ESA10474.1 - 0.02 14.5 1.3 0.026 14.2 0.1 1.8 2 0 0 2 2 2 0 F-box-like SDA1 PF05285.7 ESA10475.1 - 0.034 13.4 7.5 0.039 13.2 5.2 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.5 ESA10475.1 - 0.59 9.1 8.5 0.75 8.7 5.9 1.2 1 0 0 1 1 1 0 BUD22 p450 PF00067.17 ESA10476.1 - 7e-07 28.1 0.0 8.6e-07 27.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3110 PF11360.3 ESA10477.1 - 0.12 12.2 0.2 0.19 11.5 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3110) DUF3989 PF13150.1 ESA10477.1 - 8.4 5.9 7.1 23 4.5 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3989) eIF3_N PF09440.5 ESA10478.1 - 0.022 14.9 0.6 0.032 14.3 0.4 1.3 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain Vps39_2 PF10367.4 ESA10478.1 - 0.12 12.5 0.2 0.16 12.1 0.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 KID PF02524.9 ESA10478.1 - 0.89 9.9 6.2 9.9 6.7 0.2 3.9 3 0 0 3 3 3 0 KID repeat Profilin PF00235.14 ESA10480.1 - 2.4e-42 143.8 0.4 2.6e-42 143.7 0.3 1.0 1 0 0 1 1 1 1 Profilin AIP3 PF03915.8 ESA10481.1 - 3.5e-84 283.1 32.5 6.8e-65 219.6 8.9 2.5 2 1 1 3 3 3 2 Actin interacting protein 3 HSBP1 PF06825.7 ESA10481.1 - 0.053 13.0 3.1 0.47 10.0 0.0 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 RVT_3 PF13456.1 ESA10481.1 - 0.21 11.3 1.1 4.9 6.9 0.1 3.0 3 0 0 3 3 3 0 Reverse transcriptase-like DUF1664 PF07889.7 ESA10481.1 - 0.27 11.0 15.7 0.1 12.4 1.5 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.7 ESA10481.1 - 0.55 10.0 12.0 2 8.2 0.2 4.0 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1515 PF07439.6 ESA10481.1 - 0.94 9.3 7.0 0.69 9.7 1.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) Lectin_N PF03954.9 ESA10481.1 - 4.3 6.7 12.0 0.21 10.9 1.1 3.1 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain HMG_box PF00505.14 ESA10482.1 - 7.6e-07 29.3 0.4 1.5e-06 28.3 0.3 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA10482.1 - 0.0027 18.0 0.6 0.0051 17.1 0.4 1.4 1 0 0 1 1 1 1 HMG-box domain EF-hand_4 PF12763.2 ESA10482.1 - 0.11 12.1 1.4 0.17 11.6 0.3 1.7 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Cucumo_2B PF03263.8 ESA10482.1 - 4.7 7.5 5.7 34 4.8 0.3 2.6 2 1 0 2 2 2 0 Cucumovirus protein 2B FH2 PF02181.18 ESA10483.1 - 0.00079 18.4 5.9 0.001 18.0 4.1 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain Fib_alpha PF08702.5 ESA10483.1 - 0.0009 19.3 12.5 0.0009 19.3 8.7 1.7 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family ADIP PF11559.3 ESA10483.1 - 0.0014 18.5 6.7 0.0014 18.5 4.6 2.0 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding TMF_DNA_bd PF12329.3 ESA10483.1 - 0.0072 16.1 20.9 0.32 10.8 14.5 2.6 1 1 0 1 1 1 1 TATA element modulatory factor 1 DNA binding CDO_I PF05995.7 ESA10483.1 - 0.016 14.3 1.0 0.016 14.3 0.7 1.5 1 1 1 2 2 2 0 Cysteine dioxygenase type I Laminin_I PF06008.9 ESA10483.1 - 0.018 14.4 14.8 0.058 12.7 10.3 1.9 1 1 0 1 1 1 0 Laminin Domain I NICE-3 PF07406.6 ESA10483.1 - 0.069 12.6 4.6 0.085 12.3 3.2 1.2 1 0 0 1 1 1 0 NICE-3 protein Spc7 PF08317.6 ESA10483.1 - 0.078 11.6 15.9 0.056 12.1 9.9 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3053 PF11254.3 ESA10483.1 - 0.098 11.8 6.0 0.096 11.9 3.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) Med28 PF11594.3 ESA10483.1 - 0.1 12.8 15.8 1.1 9.5 2.6 2.2 1 1 1 2 2 2 0 Mediator complex subunit 28 DUF3450 PF11932.3 ESA10483.1 - 0.11 11.7 9.0 0.14 11.3 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4527 PF15030.1 ESA10483.1 - 0.12 11.6 4.3 0.1 11.9 1.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4527) PspA_IM30 PF04012.7 ESA10483.1 - 0.12 11.6 10.3 0.15 11.3 7.2 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF972 PF06156.8 ESA10483.1 - 0.12 12.6 15.1 0.19 12.0 3.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) APG6 PF04111.7 ESA10483.1 - 0.14 11.1 20.6 0.069 12.1 3.5 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF3911 PF13050.1 ESA10483.1 - 0.14 12.2 3.4 0.13 12.3 1.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3911) DUF745 PF05335.8 ESA10483.1 - 0.15 11.6 6.2 0.16 11.4 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Mit_KHE1 PF10173.4 ESA10483.1 - 0.15 11.8 9.0 0.17 11.6 6.3 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Atg14 PF10186.4 ESA10483.1 - 0.17 10.7 13.9 0.93 8.3 9.6 1.8 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF1943 PF09172.6 ESA10483.1 - 0.18 10.6 4.8 0.2 10.4 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) V_ATPase_I PF01496.14 ESA10483.1 - 0.2 9.4 11.4 0.22 9.3 7.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family P4Ha_N PF08336.6 ESA10483.1 - 0.22 11.3 14.2 0.07 12.9 1.7 2.4 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2396 PF09654.5 ESA10483.1 - 0.32 10.9 3.0 0.4 10.6 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2396) DUF1904 PF08921.6 ESA10483.1 - 0.42 10.6 3.7 0.14 12.2 0.9 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF1904) DUF2265 PF10023.4 ESA10483.1 - 0.51 9.4 7.8 0.56 9.2 5.4 1.0 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) DUF342 PF03961.8 ESA10483.1 - 0.55 8.5 12.9 0.67 8.2 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GAS PF13851.1 ESA10483.1 - 0.57 9.3 23.8 18 4.4 6.9 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding ParB PF08775.5 ESA10483.1 - 0.71 10.1 11.9 0.2 11.9 5.4 1.8 1 1 1 2 2 2 0 ParB family DUF904 PF06005.7 ESA10483.1 - 0.72 10.1 22.1 0.35 11.2 6.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) IZUMO PF15005.1 ESA10483.1 - 0.76 9.8 6.7 0.42 10.6 2.7 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion Syntaxin PF00804.20 ESA10483.1 - 0.89 9.7 11.8 2.4 8.3 8.2 1.8 1 1 0 1 1 1 0 Syntaxin DUF4200 PF13863.1 ESA10483.1 - 0.93 9.4 20.8 3.6 7.5 2.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) IncA PF04156.9 ESA10483.1 - 1.1 8.8 17.7 4.6 6.7 12.3 1.8 1 1 0 1 1 1 0 IncA protein NPV_P10 PF05531.7 ESA10483.1 - 1.4 9.2 9.5 5.2 7.3 5.2 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1311 PF07007.7 ESA10483.1 - 1.8 8.7 7.8 1.8 8.7 4.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1311) AcylCoA_dehyd_C PF12186.3 ESA10483.1 - 1.8 8.4 8.7 55 3.6 4.5 2.9 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal DUF4473 PF14747.1 ESA10483.1 - 1.8 8.8 10.9 0.92 9.7 3.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4473) Mis14 PF08641.7 ESA10483.1 - 1.9 8.5 12.5 0.13 12.2 3.7 1.9 1 1 1 2 2 2 0 Kinetochore protein Mis14 like DUF4446 PF14584.1 ESA10483.1 - 2.2 8.0 11.6 0.81 9.4 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4164 PF13747.1 ESA10483.1 - 2.3 8.3 11.3 0.53 10.4 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF2203 PF09969.4 ESA10483.1 - 2.8 8.1 7.8 1.3 9.2 3.1 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) AbiH PF14253.1 ESA10483.1 - 3.2 7.2 16.7 3.9 6.9 11.6 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH TPR_MLP1_2 PF07926.7 ESA10483.1 - 3.5 7.3 22.3 0.18 11.5 7.4 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein KLRAQ PF10205.4 ESA10483.1 - 3.5 7.7 12.0 31 4.6 8.3 2.1 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Rgp1 PF08737.5 ESA10483.1 - 3.6 6.5 10.8 4.3 6.3 7.5 1.0 1 0 0 1 1 1 0 Rgp1 Spore_II_R PF09551.5 ESA10483.1 - 4.4 7.3 7.7 3.1 7.8 3.7 1.7 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) DUF1664 PF07889.7 ESA10483.1 - 4.8 7.0 8.2 1.5 8.6 3.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.16 ESA10483.1 - 4.9 7.1 15.6 0.11 12.4 3.8 2.7 2 1 1 3 3 3 0 bZIP transcription factor DUF445 PF04286.7 ESA10483.1 - 5.4 6.4 10.7 6.9 6.0 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Sec20 PF03908.8 ESA10483.1 - 5.7 6.7 7.0 15 5.3 0.4 2.1 1 1 1 2 2 2 0 Sec20 DUF2205 PF10224.4 ESA10483.1 - 5.7 6.5 12.9 0.63 9.6 5.1 2.0 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Snapin_Pallidin PF14712.1 ESA10483.1 - 6.4 7.1 11.4 6.8 7.0 6.7 1.9 1 1 1 2 2 2 0 Snapin/Pallidin DUF3186 PF11382.3 ESA10483.1 - 6.5 5.7 10.8 2.3 7.2 2.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3186) Prefoldin PF02996.12 ESA10483.1 - 6.6 6.4 14.2 2.7 7.6 2.6 3.0 1 1 2 3 3 3 0 Prefoldin subunit DivIC PF04977.10 ESA10483.1 - 8.2 5.9 18.8 1.8 8.1 0.8 3.1 1 1 2 3 3 3 0 Septum formation initiator THDPS_N_2 PF14805.1 ESA10483.1 - 8.3 6.3 7.7 0.91 9.4 0.3 2.4 1 1 1 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DUF2951 PF11166.3 ESA10483.1 - 8.5 6.3 18.2 0.21 11.4 5.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) AAA_23 PF13476.1 ESA10483.1 - 9.1 6.5 19.4 14 5.9 13.4 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_C12 PF01088.16 ESA10484.1 - 3.5e-50 170.1 0.0 3.9e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Complex1_LYR PF05347.10 ESA10486.1 - 1.1e-09 37.9 0.7 1.4e-09 37.5 0.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA10486.1 - 1.2e-06 28.6 0.6 1.6e-06 28.1 0.4 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Nsp1_C PF05064.8 ESA10487.1 - 3.2e-23 81.6 4.7 3.2e-23 81.6 3.3 2.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region LcrG PF07216.7 ESA10487.1 - 0.14 12.2 3.2 0.32 11.0 2.2 1.6 1 0 0 1 1 1 0 LcrG protein Trypsin_2 PF13365.1 ESA10488.1 - 0.0032 17.4 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 ESA10488.1 - 0.041 13.4 7.6 0.23 11.0 5.3 2.3 1 1 0 1 1 1 0 Trypsin Pkinase PF00069.20 ESA10489.1 - 9.8e-25 87.1 0.9 2e-24 86.1 0.6 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10489.1 - 1.2e-22 80.2 0.0 1.6e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2439 PF10382.4 ESA10489.1 - 0.0023 18.1 1.4 0.0062 16.7 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) BCS1_N PF08740.6 ESA10489.1 - 0.02 14.5 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 BCS1 N terminal DZR PF12773.2 ESA10489.1 - 0.05 13.4 1.9 0.093 12.5 1.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon Thioredoxin_2 PF13098.1 ESA10489.1 - 0.15 12.2 2.5 2 8.6 1.7 2.6 1 1 0 1 1 1 0 Thioredoxin-like domain DUF2004 PF09406.5 ESA10489.1 - 0.19 11.7 2.1 0.81 9.7 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2004) zf-ribbon_3 PF13248.1 ESA10489.1 - 0.36 10.0 0.1 0.36 10.0 0.1 2.2 3 0 0 3 3 3 0 zinc-ribbon domain BCS1_N PF08740.6 ESA10490.1 - 9.6e-05 22.0 0.3 0.69 9.4 0.0 3.6 3 0 0 3 3 3 2 BCS1 N terminal Lipoprot_C PF08794.5 ESA10490.1 - 0.00039 20.3 0.4 3.4 7.5 0.0 4.2 5 0 0 5 5 5 2 Lipoprotein GNA1870 C terminal like Prp18 PF02840.10 ESA10490.1 - 0.0026 17.5 0.3 1.7 8.4 0.0 3.2 3 0 0 3 3 3 1 Prp18 domain PA14_2 PF10528.4 ESA10490.1 - 2.5 8.0 9.9 16 5.4 0.1 4.4 5 0 0 5 5 5 0 GLEYA domain Sir1 PF11603.3 ESA10491.1 - 0.49 10.5 6.8 0.21 11.7 1.7 2.1 2 0 0 2 2 2 0 Regulatory protein Sir1 SRI PF08236.6 ESA10491.1 - 2.8 7.9 6.9 16 5.5 0.1 3.2 3 1 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Trypsin_2 PF13365.1 ESA10492.1 - 0.014 15.3 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 Trypsin-like peptidase domain Hydrolase PF00702.21 ESA10494.1 - 7.7e-28 98.3 0.0 1.2e-26 94.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 ESA10494.1 - 8.2e-18 64.5 1.7 1.2e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus HAD PF12710.2 ESA10494.1 - 1.1e-13 51.8 0.0 2.7e-13 50.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESA10494.1 - 5.3e-13 48.5 5.3 9.5e-13 47.7 3.6 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 ESA10494.1 - 1.6e-08 34.4 0.0 3.8e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESA10494.1 - 4.6e-06 26.4 0.3 0.00099 18.7 0.8 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Kelch_6 PF13964.1 ESA10496.1 - 5.5e-21 73.8 9.1 0.00066 19.7 0.1 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA10496.1 - 8.8e-21 73.4 1.5 0.0026 17.5 0.0 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA10496.1 - 2.8e-19 68.3 14.7 0.0015 18.0 0.0 5.8 5 1 0 5 5 5 5 Kelch motif Kelch_5 PF13854.1 ESA10496.1 - 1.3e-18 66.5 13.6 7.3e-06 25.8 0.2 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 ESA10496.1 - 3.6e-16 58.8 1.4 0.0053 16.8 0.0 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA10496.1 - 4.2e-16 57.9 0.3 0.0012 18.5 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Rax2 PF12768.2 ESA10496.1 - 0.092 11.9 0.0 0.33 10.1 0.0 1.8 2 0 0 2 2 2 0 Cortical protein marker for cell polarity FBA_3 PF08268.7 ESA10496.1 - 0.17 11.6 0.9 30 4.3 0.0 2.8 2 1 1 3 3 3 0 F-box associated domain DDE_Tnp_ISAZ013 PF07592.6 ESA10498.1 - 5.1e-05 22.1 0.0 0.15 10.8 0.0 2.1 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain GcpE PF04551.9 ESA10499.1 - 0.07 11.9 0.3 0.091 11.5 0.2 1.1 1 0 0 1 1 1 0 GcpE protein Sec8_exocyst PF04048.9 ESA10499.1 - 0.52 9.9 4.6 11 5.6 0.6 2.6 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain E1-E2_ATPase PF00122.15 ESA10501.1 - 7.1e-54 182.2 6.3 1.1e-53 181.6 4.4 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESA10501.1 - 5.7e-28 98.7 0.0 7.6e-27 95.1 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.16 ESA10501.1 - 6.7e-18 64.8 3.4 9.2e-18 64.3 0.0 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus HAD PF12710.2 ESA10501.1 - 2.5e-14 53.8 0.0 1.1e-13 51.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA10501.1 - 8.4e-09 35.2 0.0 2.2e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESA10501.1 - 1.3e-05 24.9 0.7 0.0012 18.4 0.8 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.5 ESA10501.1 - 0.037 13.6 0.6 0.059 12.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) DUF1356 PF07092.7 ESA10502.1 - 0.094 11.8 1.3 0.099 11.8 0.2 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) BTB PF00651.26 ESA10503.1 - 9.3e-10 38.4 0.0 1e-09 38.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain E1_DerP2_DerF2 PF02221.10 ESA10504.1 - 2.7e-12 47.1 0.1 3.4e-12 46.7 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 ESA10504.1 - 0.0045 17.0 0.1 0.0065 16.5 0.1 1.4 1 0 0 1 1 1 1 ML-like domain PHP PF02811.14 ESA10506.1 - 2.6e-13 50.1 0.0 3.4e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 PHP domain O-FucT PF10250.4 ESA10508.1 - 2e-09 37.0 6.7 4.9e-08 32.4 4.7 2.8 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Velvet PF11754.3 ESA10509.1 - 2.7e-14 53.2 0.0 3.8e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Velvet factor FAR1 PF03101.10 ESA10510.1 - 1.2e-11 45.0 0.1 1.6e-11 44.5 0.1 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA10510.1 - 6.1e-07 28.9 0.2 0.00053 19.4 0.0 2.3 2 0 0 2 2 2 2 MuDR family transposase EAP30 PF04157.11 ESA10512.1 - 2.7e-53 180.4 0.0 3e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_L12 PF00542.14 ESA10513.1 - 3e-20 72.0 9.8 3e-20 71.9 5.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain DUF2267 PF10025.4 ESA10513.1 - 0.021 14.8 0.1 0.034 14.1 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Ribosomal_60s PF00428.14 ESA10513.1 - 0.83 10.0 7.0 0.16 12.3 1.0 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Ribosomal_L28e PF01778.12 ESA10514.1 - 1.1e-38 132.2 1.3 1.5e-38 131.8 0.9 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family Ank PF00023.25 ESA10515.1 - 3e-16 58.3 0.2 3.3e-07 29.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 ESA10515.1 - 1.9e-14 53.7 1.1 5.5e-07 29.8 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA10515.1 - 2.6e-14 53.2 0.1 1.3e-07 31.8 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA10515.1 - 2e-12 46.0 0.1 0.00045 20.1 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESA10515.1 - 2.2e-12 46.7 0.2 2.8e-08 33.7 0.2 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) DUF3153 PF11353.3 ESA10515.1 - 0.15 11.4 1.7 0.18 11.2 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) Tht1 PF04163.7 ESA10515.1 - 0.17 10.2 0.6 0.22 9.9 0.4 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Pkinase_Tyr PF07714.12 ESA10519.1 - 1.4e-14 53.8 0.0 4.8e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10519.1 - 2.8e-11 43.0 0.3 2.8e-11 43.0 0.2 2.4 3 0 0 3 3 3 1 Protein kinase domain Thioredoxin_7 PF13899.1 ESA10519.1 - 0.031 14.2 3.6 19 5.3 0.0 3.9 3 0 0 3 3 3 0 Thioredoxin-like NOB1_Zn_bind PF08772.6 ESA10519.1 - 0.28 11.0 10.2 0.37 10.6 0.7 3.7 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like NapB PF03892.9 ESA10519.1 - 0.64 9.6 5.8 0.31 10.7 0.1 2.6 1 1 0 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) DDE_Tnp_ISAZ013 PF07592.6 ESA10520.1 - 0.077 11.7 0.0 0.14 10.8 0.0 1.4 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF2927 PF11150.3 ESA10520.1 - 0.088 12.4 0.1 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2927) GMC_oxred_N PF00732.14 ESA10521.1 - 4.1e-33 114.7 0.0 5.8e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ESA10521.1 - 0.00016 20.7 0.0 0.00022 20.2 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 ESA10521.1 - 0.00054 18.9 0.0 0.00078 18.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA10521.1 - 0.005 16.8 0.0 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESA10521.1 - 0.065 12.3 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.1 ESA10521.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 FAD-NAD(P)-binding TAP_C PF03943.8 ESA10521.1 - 0.14 11.5 0.5 0.29 10.5 0.3 1.5 1 0 0 1 1 1 0 TAP C-terminal domain FAD_binding_2 PF00890.19 ESA10521.1 - 0.16 10.7 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Ank_2 PF12796.2 ESA10522.1 - 8e-08 32.5 0.1 4.4e-07 30.1 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA10522.1 - 9.2e-08 32.4 0.1 0.012 16.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESA10522.1 - 4.6e-05 23.0 0.0 0.08 12.7 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESA10522.1 - 5.1e-05 23.3 0.0 0.0052 17.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA10522.1 - 8.1e-05 22.5 0.0 3.3 8.2 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Peptidase_M13_N PF05649.8 ESA10523.1 - 0.044 12.8 0.0 0.89 8.5 0.0 2.0 1 1 0 2 2 2 0 Peptidase family M13 E1_DerP2_DerF2 PF02221.10 ESA10525.1 - 0.09 13.0 0.6 0.17 12.1 0.4 1.4 1 1 0 1 1 1 0 ML domain P4Ha_N PF08336.6 ESA10527.1 - 0.12 12.2 0.1 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Pkinase_Tyr PF07714.12 ESA10528.1 - 1.8e-20 73.1 0.0 4.3e-15 55.4 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA10528.1 - 7e-16 58.1 10.2 4.5e-15 55.5 0.3 3.3 3 0 0 3 3 3 1 Protein kinase domain BCS1_N PF08740.6 ESA10528.1 - 1.9e-10 40.6 0.0 0.001 18.7 0.0 3.4 3 0 0 3 3 3 3 BCS1 N terminal DZR PF12773.2 ESA10528.1 - 0.025 14.4 17.8 0.53 10.1 1.5 3.5 3 0 0 3 3 3 0 Double zinc ribbon CENP-F_leu_zip PF10473.4 ESA10528.1 - 0.12 12.1 1.5 25 4.7 0.0 2.9 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 THOC7 PF05615.8 ESA10528.1 - 0.17 12.1 4.2 9.4 6.5 0.0 3.4 3 0 0 3 3 3 0 Tho complex subunit 7 DUF4413 PF14372.1 ESA10528.1 - 0.19 11.7 11.1 0.96 9.4 0.3 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4413) NOB1_Zn_bind PF08772.6 ESA10528.1 - 1.4 8.8 20.0 1.8 8.4 0.3 4.2 3 2 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.1 ESA10528.1 - 2.1 7.6 20.6 0.8 8.9 0.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA10528.1 - 2.8 7.5 16.0 1.9 8.0 0.1 3.7 3 0 0 3 3 3 0 zinc-ribbon domain Mob_synth_C PF06463.8 ESA10528.1 - 5.3 6.7 10.5 4.9 6.8 0.3 3.2 3 0 0 3 3 3 0 Molybdenum Cofactor Synthesis C FYVE PF01363.16 ESA10528.1 - 5.4 6.9 10.3 23 4.9 0.7 3.5 3 0 0 3 3 3 0 FYVE zinc finger Dimer_Tnp_hAT PF05699.9 ESA10529.1 - 3e-08 33.1 0.1 6e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SAM_2 PF07647.12 ESA10530.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA10530.1 - 0.068 13.3 0.1 0.15 12.2 0.0 1.6 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Helicase_C PF00271.26 ESA10531.1 - 4.4e-06 26.4 0.0 1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Pkinase_Tyr PF07714.12 ESA10532.1 - 2.1e-37 128.5 0.0 1.9e-32 112.3 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA10532.1 - 1.1e-34 119.7 0.2 1.8e-31 109.2 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Stc1 PF12898.2 ESA10532.1 - 0.017 15.1 4.3 2.1 8.4 0.5 2.8 3 0 0 3 3 3 0 Stc1 domain DZR PF12773.2 ESA10532.1 - 6.4 6.6 10.2 14 5.5 0.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon S-antigen PF05756.6 ESA10533.1 - 1.6 8.7 5.3 2.8 7.9 3.5 1.7 1 1 0 1 1 1 0 S-antigen protein Methyltransf_23 PF13489.1 ESA10536.1 - 4.5e-08 32.9 0.0 1.2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA10536.1 - 1.2e-06 29.1 0.0 2.9e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA10536.1 - 3.3e-05 24.2 0.1 0.0035 17.8 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA10536.1 - 3.3e-05 23.5 0.1 0.02 14.5 0.0 2.8 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.1 ESA10536.1 - 0.00011 22.5 0.2 0.0014 18.9 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA10536.1 - 0.00026 21.4 0.0 0.0046 17.4 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain TehB PF03848.9 ESA10536.1 - 0.00038 19.6 0.1 0.0038 16.4 0.0 2.4 1 1 1 2 2 2 1 Tellurite resistance protein TehB Methyltransf_26 PF13659.1 ESA10536.1 - 0.0017 18.3 0.0 0.0068 16.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA10536.1 - 0.0071 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain WD40 PF00400.27 ESA10537.1 - 2e-21 75.0 8.1 7.9e-11 41.4 0.2 5.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Pkinase_Tyr PF07714.12 ESA10538.1 - 1.2e-25 90.0 0.0 4.7e-25 88.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10538.1 - 1.7e-24 86.3 0.2 4.3e-24 85.0 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain HypA PF01155.14 ESA10538.1 - 0.0044 16.6 2.5 0.046 13.4 0.1 2.4 2 0 0 2 2 2 1 Hydrogenase expression/synthesis hypA family ACCA PF03255.9 ESA10538.1 - 0.16 11.5 1.0 0.61 9.6 0.2 2.3 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DZR PF12773.2 ESA10538.1 - 2.4 8.0 9.8 4 7.3 0.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon p450 PF00067.17 ESA10542.1 - 8.8e-45 153.0 0.2 1.2e-44 152.6 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1091 PF06477.8 ESA10542.1 - 0.0011 19.3 3.0 0.28 11.6 0.2 3.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1091) Abhydrolase_6 PF12697.2 ESA10543.1 - 6.6e-22 78.5 0.0 8.6e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA10543.1 - 1.7e-19 69.9 0.0 2.4e-18 66.2 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESA10543.1 - 5.2e-17 61.4 0.0 9.1e-17 60.6 0.0 1.3 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 ESA10543.1 - 1.3e-08 34.6 0.0 3.4e-07 30.0 0.0 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 ESA10543.1 - 0.0012 18.3 0.1 0.28 10.5 0.0 2.9 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.8 ESA10543.1 - 0.0089 15.6 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.6 ESA10543.1 - 0.019 14.0 0.0 2.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.8 ESA10543.1 - 0.057 13.0 0.0 0.083 12.4 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.15 ESA10543.1 - 0.091 12.1 0.0 0.18 11.2 0.0 1.6 2 0 0 2 2 2 0 Putative esterase SMN PF06003.7 ESA10544.1 - 1.4e-08 34.1 14.9 1.4e-08 34.1 10.3 3.3 1 1 2 3 3 3 2 Survival motor neuron protein (SMN) TYW3 PF02676.9 ESA10545.1 - 2.1e-27 95.5 0.1 3.1e-27 95.0 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 LANC_like PF05147.8 ESA10545.1 - 0.0073 14.9 0.2 0.0083 14.7 0.1 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Toprim PF01751.17 ESA10545.1 - 0.093 12.7 1.3 0.23 11.4 0.9 1.7 1 1 0 1 1 1 0 Toprim domain NIPSNAP PF07978.8 ESA10546.1 - 5.1e-35 119.5 0.0 3.1e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 NIPSNAP Glucan_synthase PF02364.10 ESA10546.1 - 0.0036 15.2 0.2 0.0047 14.8 0.1 1.1 1 0 0 1 1 1 1 1,3-beta-glucan synthase component DUF4050 PF13259.1 ESA10547.1 - 1.5e-20 73.3 1.0 2.3e-20 72.7 0.7 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4050) RRM_1 PF00076.17 ESA10548.1 - 2.4e-14 52.7 0.3 8.3e-10 38.1 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA10548.1 - 6.8e-11 41.8 0.2 9.2e-06 25.4 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA10548.1 - 2.6e-06 27.3 1.2 0.014 15.3 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA10548.1 - 0.0073 16.0 0.2 1.7 8.4 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif TPK_B1_binding PF04265.9 ESA10549.1 - 0.048 13.3 0.1 0.083 12.6 0.0 1.6 1 1 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain MSA-2c PF12238.3 ESA10549.1 - 0.057 13.0 6.5 0.065 12.8 4.5 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c PMT_C PF11647.3 ESA10549.1 - 0.19 11.3 0.7 0.73 9.4 0.0 2.1 2 1 1 3 3 3 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 MFS_1 PF07690.11 ESA10550.1 - 4.6e-21 74.9 38.6 5.8e-18 64.7 13.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Flavi_M PF01004.14 ESA10550.1 - 0.0016 17.8 0.0 0.011 15.1 0.0 2.4 1 0 0 1 1 1 1 Flavivirus envelope glycoprotein M RNA_pol_Rpb2_1 PF04563.10 ESA10550.1 - 0.003 16.5 1.5 0.0035 16.3 0.2 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit Bromodomain PF00439.20 ESA10551.1 - 2.5e-15 56.1 0.3 2.7e-15 56.0 0.2 1.0 1 0 0 1 1 1 1 Bromodomain DUF659 PF04937.10 ESA10553.1 - 0.0026 17.2 0.0 0.0038 16.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) Sel1 PF08238.7 ESA10554.1 - 6.6e-132 427.0 72.5 1.7e-12 47.5 0.2 16.0 16 0 0 16 16 16 15 Sel1 repeat TPR_17 PF13431.1 ESA10554.1 - 1.3e-06 28.1 21.5 3 8.2 0.4 10.5 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10554.1 - 5.3e-06 26.9 0.5 1.4 9.7 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA10554.1 - 0.0088 16.4 26.9 1.7 9.3 0.1 8.3 10 0 0 10 10 10 3 Tetratricopeptide repeat 23S_rRNA_IVP PF05635.6 ESA10554.1 - 0.054 13.4 0.7 5.2 7.0 0.1 3.5 3 1 0 3 3 3 0 23S rRNA-intervening sequence protein CathepsinC_exc PF08773.6 ESA10554.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.8 3 1 0 3 3 3 0 Cathepsin C exclusion domain Sel1 PF08238.7 ESA10555.1 - 1.2e-08 35.2 4.6 0.0013 19.2 0.5 3.6 3 0 0 3 3 3 3 Sel1 repeat Pkinase PF00069.20 ESA10555.1 - 8.5e-05 21.8 0.0 0.00013 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10555.1 - 0.0013 17.9 0.0 0.0033 16.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase TPR_16 PF13432.1 ESA10555.1 - 0.073 13.7 0.3 2.9 8.6 0.0 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10555.1 - 0.14 11.8 1.8 0.33 10.6 1.2 1.7 1 0 0 1 1 1 0 TPR repeat CAP PF00188.21 ESA10556.1 - 9.1e-12 45.5 0.0 1.2e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF4252 PF14060.1 ESA10556.1 - 0.0019 17.7 0.7 0.0032 17.0 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4252) Sel1 PF08238.7 ESA10558.1 - 9e-160 515.6 73.9 2.3e-11 43.9 0.5 18.1 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA10558.1 - 5.8e-06 26.4 32.5 1.1 9.8 0.1 12.2 15 0 0 15 15 15 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA10558.1 - 0.029 14.4 0.1 4.4 7.3 0.0 4.4 6 1 1 7 7 7 0 Influenza Matrix protein (M1) C-terminal domain AdoMet_MTase PF07757.8 ESA10558.1 - 0.61 10.2 7.1 1.1 9.3 0.1 4.4 5 1 1 6 6 6 0 Predicted AdoMet-dependent methyltransferase F-box-like PF12937.2 ESA10559.1 - 6.5e-06 25.7 0.3 2.1e-05 24.1 0.2 1.9 1 0 0 1 1 1 1 F-box-like rpo132 PF12415.3 ESA10559.1 - 0.6 9.1 3.5 0.24 10.3 0.2 2.0 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase OMS28_porin PF03532.8 ESA10560.1 - 0.021 13.9 1.1 0.021 13.9 0.8 1.0 1 0 0 1 1 1 0 OMS28 porin Apelin PF15360.1 ESA10560.1 - 0.028 14.6 1.0 0.037 14.2 0.3 1.5 1 1 0 1 1 1 0 APJ endogenous ligand DUF1371 PF07115.6 ESA10561.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1371) Sel1 PF08238.7 ESA10565.1 - 1.1e-109 356.3 44.0 5.5e-11 42.7 0.1 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA10565.1 - 4.6e-09 36.1 22.4 1.8 9.1 0.1 9.6 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA10565.1 - 5.9e-05 22.9 31.8 8.7 6.8 0.0 10.6 10 1 1 11 11 11 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10565.1 - 0.0069 16.0 2.7 0.0069 16.0 1.9 7.9 4 4 3 8 8 8 3 TPR repeat Ribosomal_S17e PF00833.13 ESA10565.1 - 0.092 12.5 0.2 0.17 11.6 0.2 1.4 1 0 0 1 1 1 0 Ribosomal S17 Pkinase PF00069.20 ESA10566.1 - 1.8e-25 89.6 0.5 3.7e-25 88.5 0.3 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10566.1 - 1.9e-22 79.5 0.0 2.5e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA10566.1 - 0.035 13.1 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA10566.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HMGL-like PF00682.14 ESA10567.1 - 0.015 14.9 0.4 0.018 14.7 0.3 1.1 1 0 0 1 1 1 0 HMGL-like TFR_dimer PF04253.10 ESA10567.1 - 0.051 13.1 2.0 4.8 6.7 0.2 2.4 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain DUF16 PF01519.11 ESA10567.1 - 0.083 13.1 5.8 0.16 12.1 3.6 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Cupin_8 PF13621.1 ESA10567.1 - 1.5 8.2 7.0 6 6.2 4.9 1.9 1 1 0 1 1 1 0 Cupin-like domain Cystatin PF00031.16 ESA10568.1 - 0.067 13.3 1.5 0.067 13.3 1.0 2.1 2 1 0 2 2 2 0 Cystatin domain YhfH PF14149.1 ESA10568.1 - 0.14 11.9 3.3 8.1 6.3 0.0 2.5 2 0 0 2 2 2 0 YhfH-like protein RNase_H PF00075.19 ESA10570.1 - 0.006 16.9 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 RNase H DUF3186 PF11382.3 ESA10570.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) SPRY PF00622.23 ESA10571.1 - 1.3e-17 64.0 0.8 1.5e-17 63.8 0.5 1.1 1 0 0 1 1 1 1 SPRY domain zf-BED PF02892.10 ESA10572.1 - 0.00024 20.7 1.2 0.091 12.5 0.0 2.6 2 0 0 2 2 2 2 BED zinc finger Gal_Lectin PF02140.13 ESA10572.1 - 0.064 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Galactose binding lectin domain DUF3122 PF11320.3 ESA10573.1 - 0.062 13.2 0.3 0.069 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) Unstab_antitox PF09720.5 ESA10573.1 - 0.063 12.9 0.7 0.18 11.5 0.1 2.1 2 1 1 3 3 3 0 Putative addiction module component ADH_zinc_N PF00107.21 ESA10574.1 - 3e-19 68.8 0.0 5.3e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA10574.1 - 0.0013 19.6 0.0 0.0028 18.5 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.3 ESA10574.1 - 0.064 12.3 0.0 1.9 7.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2855) Glyco_hydro_3 PF00933.16 ESA10574.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain Pkinase_Tyr PF07714.12 ESA10575.1 - 3e-09 36.3 0.0 4.1e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10575.1 - 6.2e-05 22.2 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Baculo_p48 PF04878.8 ESA10576.1 - 0.034 13.0 0.0 0.036 13.0 0.0 1.0 1 0 0 1 1 1 0 Baculovirus P48 protein DUF2805 PF10985.3 ESA10577.1 - 0.062 13.2 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) DUF663 PF04950.7 ESA10577.1 - 0.089 11.7 0.1 0.092 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF663) SEA PF01390.15 ESA10580.1 - 0.003 17.2 0.0 0.003 17.2 0.0 1.1 1 0 0 1 1 1 1 SEA domain DUF3824 PF12868.2 ESA10584.1 - 0.072 14.0 0.7 0.086 13.7 0.5 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) FAM219A PF15260.1 ESA10584.1 - 0.65 10.3 3.3 0.72 10.2 2.3 1.1 1 0 0 1 1 1 0 Protein family FAM219A TMEM154 PF15102.1 ESA10584.1 - 2.6 7.7 5.7 2.8 7.6 3.9 1.1 1 0 0 1 1 1 0 TMEM154 protein family DUF822 PF05687.8 ESA10584.1 - 5.5 7.3 6.7 6.2 7.1 4.7 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF822) Ery_res_leader2 PF08057.6 ESA10585.1 - 0.056 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Erythromycin resistance leader peptide AAA_12 PF13087.1 ESA10586.1 - 3.2e-24 85.4 5.0 3.2e-24 85.4 3.5 3.0 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.1 ESA10586.1 - 1.8e-09 37.5 11.2 0.00019 21.1 0.1 4.5 4 1 1 5 5 5 2 AAA domain AAA_30 PF13604.1 ESA10586.1 - 2.5e-06 27.2 0.0 5.9e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA10586.1 - 0.00017 21.2 0.0 0.0014 18.3 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 ESA10586.1 - 0.018 15.1 0.0 0.073 13.2 0.0 2.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 ESA10586.1 - 0.022 14.9 0.1 0.28 11.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 ESA10586.1 - 0.038 13.4 0.2 0.5 9.8 0.2 2.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF331 PF03889.8 ESA10587.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function Cu-oxidase_3 PF07732.10 ESA10588.1 - 0.4 10.4 4.0 0.58 9.8 2.8 1.5 1 1 0 1 1 1 0 Multicopper oxidase Shadoo PF14999.1 ESA10589.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Pkinase PF00069.20 ESA10590.1 - 3.2e-58 196.9 0.0 5.2e-58 196.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10590.1 - 9.1e-23 80.6 0.4 3.5e-22 78.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESA10590.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA10590.1 - 0.021 14.3 0.5 0.021 14.3 0.4 2.1 2 1 0 2 2 2 0 Choline/ethanolamine kinase Kinase-like PF14531.1 ESA10590.1 - 0.063 12.2 0.0 0.41 9.5 0.0 2.0 2 0 0 2 2 2 0 Kinase-like ABC1 PF03109.11 ESA10590.1 - 0.082 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC1 family SR-25 PF10500.4 ESA10592.1 - 0.89 8.9 10.4 0.88 8.9 7.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1076 PF06416.7 ESA10594.1 - 0.0099 15.5 0.2 0.039 13.6 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1076) Rifin_STEVOR PF02009.11 ESA10594.1 - 0.68 9.5 3.0 0.77 9.3 1.6 1.3 1 1 0 1 1 1 0 Rifin/stevor family TMEM154 PF15102.1 ESA10594.1 - 2.3 7.9 5.3 4.5 6.9 3.7 1.4 1 0 0 1 1 1 0 TMEM154 protein family McrBC PF10117.4 ESA10595.1 - 0.096 11.5 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component UBN2_2 PF14227.1 ESA10597.1 - 0.023 14.2 1.1 0.046 13.2 0.7 1.5 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type IL13 PF03487.8 ESA10597.1 - 0.024 14.3 0.0 5.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Interleukin-13 DUF3832 PF12909.2 ESA10597.1 - 0.028 14.4 0.6 2.3 8.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3832) Ca_chan_IQ PF08763.6 ESA10597.1 - 0.055 12.7 1.4 0.56 9.4 0.4 2.4 2 0 0 2 2 2 0 Voltage gated calcium channel IQ domain GAT PF03127.9 ESA10597.1 - 0.069 13.1 0.1 0.085 12.8 0.1 1.1 1 0 0 1 1 1 0 GAT domain DUF4167 PF13763.1 ESA10597.1 - 0.088 12.8 0.3 4.5 7.3 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4167) VD10_N PF08476.5 ESA10597.1 - 0.099 12.1 1.0 7 6.2 0.1 2.2 1 1 1 2 2 2 0 Viral D10 N-terminal PWI PF01480.12 ESA10597.1 - 0.12 12.4 0.3 0.34 11.0 0.2 1.8 1 1 0 1 1 1 0 PWI domain PspB PF06667.7 ESA10597.1 - 0.15 12.0 0.2 2.8 7.9 0.0 2.0 1 1 1 2 2 2 0 Phage shock protein B Kelch_4 PF13418.1 ESA10598.1 - 1.8e-21 75.6 5.7 2.8e-05 23.7 0.0 4.4 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA10598.1 - 4e-16 58.4 13.4 3.7e-05 23.7 0.1 4.2 2 2 2 4 4 4 3 Kelch motif Kelch_5 PF13854.1 ESA10598.1 - 3.1e-15 55.7 8.4 0.0012 18.7 0.1 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.1 ESA10598.1 - 3.6e-15 55.6 8.0 0.0032 17.6 0.0 4.4 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA10598.1 - 1.6e-12 46.6 4.2 0.0014 18.3 0.0 4.4 4 1 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA10598.1 - 2.6e-12 46.0 15.0 0.00096 18.6 0.3 4.9 4 1 0 4 4 4 3 Kelch motif TPR_11 PF13414.1 ESA10600.1 - 2.8e-56 187.0 35.0 1.1e-11 44.1 0.2 9.7 7 3 3 11 11 11 8 TPR repeat TPR_1 PF00515.23 ESA10600.1 - 4.8e-50 165.2 44.7 6.3e-06 25.5 0.0 14.4 16 0 0 16 16 15 11 Tetratricopeptide repeat TPR_2 PF07719.12 ESA10600.1 - 9.8e-44 143.7 37.8 0.00055 19.6 0.0 14.8 15 0 0 15 15 15 11 Tetratricopeptide repeat TPR_8 PF13181.1 ESA10600.1 - 3.9e-38 126.3 28.8 0.0061 16.2 0.0 14.4 15 0 0 15 15 15 9 Tetratricopeptide repeat TPR_9 PF13371.1 ESA10600.1 - 2.1e-30 104.3 6.6 0.00031 20.5 0.0 9.4 5 4 4 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10600.1 - 6.3e-28 96.7 9.1 0.001 19.6 0.2 8.5 4 2 2 8 8 8 7 Tetratricopeptide repeat TPR_17 PF13431.1 ESA10600.1 - 2.3e-27 92.8 25.5 1.8e-05 24.5 0.0 12.4 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESA10600.1 - 1.5e-26 92.0 26.2 1.2e-08 34.7 1.0 9.0 6 4 2 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA10600.1 - 1.7e-19 69.9 16.7 0.00035 20.8 0.6 8.2 6 2 2 8 8 8 6 Tetratricopeptide repeat Apc3 PF12895.2 ESA10600.1 - 4e-19 68.5 17.6 7.3e-05 22.8 2.4 7.6 5 2 2 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESA10600.1 - 8.9e-15 53.8 13.8 0.19 12.4 0.0 12.6 9 3 5 14 14 12 2 Tetratricopeptide repeat NARP1 PF12569.3 ESA10600.1 - 2.7e-11 42.9 3.9 0.0007 18.4 0.0 4.6 4 0 0 4 4 4 3 NMDA receptor-regulated protein 1 TPR_15 PF13429.1 ESA10600.1 - 2.7e-10 39.7 3.7 0.021 13.8 0.1 5.8 3 2 2 5 5 5 3 Tetratricopeptide repeat ChAPs PF09295.5 ESA10600.1 - 1.5e-07 30.5 0.4 0.014 14.1 0.0 3.7 3 0 0 3 3 3 3 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.1 ESA10600.1 - 1e-06 28.7 22.5 14 6.3 0.0 11.3 10 1 0 10 10 10 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA10600.1 - 3e-05 23.5 18.0 10 6.2 0.2 9.8 12 0 0 12 12 11 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA10600.1 - 7.6e-05 22.7 1.9 5 7.3 0.0 5.8 5 2 1 6 6 6 1 Tetratricopeptide repeat zf-RING_UBOX PF13445.1 ESA10600.1 - 0.0023 17.6 6.7 0.0029 17.2 3.0 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.1 ESA10600.1 - 0.0084 15.9 4.8 0.02 14.7 3.3 1.7 1 0 0 1 1 1 1 Ring finger domain SHNi-TPR PF10516.4 ESA10600.1 - 0.019 14.2 6.0 4.9 6.4 0.0 5.7 7 0 0 7 7 7 0 SHNi-TPR TPR_18 PF13512.1 ESA10600.1 - 0.097 12.6 3.2 12 5.9 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA10600.1 - 0.45 10.4 19.3 0.87 9.5 0.5 6.7 7 1 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat Kelch_3 PF13415.1 ESA10601.1 - 2.5e-40 135.7 5.7 2e-10 40.5 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA10601.1 - 4.1e-36 122.3 0.9 9e-08 31.9 0.0 5.2 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA10601.1 - 5.8e-36 122.0 9.2 1.7e-11 43.7 0.1 5.5 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA10601.1 - 9.7e-34 114.6 8.8 9.1e-11 41.1 0.7 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 ESA10601.1 - 2.3e-30 103.4 5.8 3.4e-08 33.3 0.1 5.1 3 1 2 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ESA10601.1 - 2.7e-23 80.8 6.3 1.1e-05 25.0 0.1 5.3 5 0 0 5 5 5 5 Kelch motif RAG2 PF03089.9 ESA10601.1 - 5.8e-08 31.8 3.0 0.0038 16.0 0.2 4.9 1 1 3 4 4 4 1 Recombination activating protein 2 LRR_6 PF13516.1 ESA10602.1 - 1.2e-12 46.4 17.8 0.012 15.6 0.0 7.8 9 0 0 9 9 9 4 Leucine Rich repeat F-box-like PF12937.2 ESA10602.1 - 2.3e-10 40.0 0.7 6.5e-10 38.5 0.5 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA10602.1 - 1e-06 28.2 9.9 0.077 12.6 0.2 5.6 2 1 2 6 6 6 3 Leucine Rich repeats (2 copies) F-box PF00646.28 ESA10602.1 - 0.00016 21.2 0.1 0.00085 18.9 0.1 2.4 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.28 ESA10602.1 - 0.00089 18.9 15.5 11 6.5 0.1 7.4 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_7 PF13504.1 ESA10602.1 - 0.071 13.3 12.1 54 4.6 0.1 7.2 7 0 0 7 7 7 0 Leucine rich repeat DUF2281 PF10047.4 ESA10602.1 - 0.076 13.3 0.0 0.26 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2281) DUF4114 PF13448.1 ESA10602.1 - 7.8 7.3 8.1 29 5.5 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4114) TLD PF07534.11 ESA10603.1 - 2.8e-10 40.3 4.4 7.9e-10 38.8 3.0 1.8 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA10603.1 - 0.28 11.0 1.7 2.7 7.8 0.0 3.0 2 1 1 3 3 3 0 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA10604.1 - 3.8e-35 121.2 0.0 4.8e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10604.1 - 1.6e-33 115.9 0.0 2.3e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA10604.1 - 0.0037 17.0 0.5 0.0057 16.4 0.4 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA10604.1 - 0.011 14.8 0.3 0.016 14.2 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Bac_DnaA PF00308.13 ESA10607.1 - 0.0043 16.7 1.0 0.35 10.4 0.0 2.3 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_22 PF13401.1 ESA10607.1 - 0.01 16.0 0.0 0.047 13.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain HMG_box_2 PF09011.5 ESA10608.1 - 0.0033 17.7 0.9 0.008 16.5 0.1 2.1 1 1 1 2 2 2 1 HMG-box domain DUF4355 PF14265.1 ESA10608.1 - 0.094 12.6 0.5 0.094 12.6 0.3 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4355) Pkinase_Tyr PF07714.12 ESA10609.1 - 0.0052 15.8 0.0 0.0067 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10609.1 - 0.012 14.7 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10610.1 - 6.9e-06 25.3 0.2 8.8e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10610.1 - 0.001 18.2 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Raptor_N PF14538.1 ESA10610.1 - 0.072 12.9 0.4 0.089 12.6 0.3 1.2 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Cu-binding_MopE PF11617.3 ESA10610.1 - 0.26 11.1 0.2 0.26 11.1 0.1 2.2 3 0 0 3 3 3 0 Protein metal binding site ComK PF06338.6 ESA10611.1 - 0.024 14.0 0.1 0.04 13.3 0.1 1.3 1 0 0 1 1 1 0 ComK protein Sel1 PF08238.7 ESA10612.1 - 1.9e-91 298.5 42.7 1.9e-08 34.6 0.1 15.8 15 1 1 16 16 16 13 Sel1 repeat ETF_alpha PF00766.14 ESA10612.1 - 7.1e-05 22.3 4.3 16 5.1 0.0 5.5 4 1 1 5 5 5 1 Electron transfer flavoprotein FAD-binding domain ANTAR PF03861.9 ESA10612.1 - 0.006 16.1 5.1 13 5.4 0.0 5.4 7 0 0 7 7 7 1 ANTAR domain DUF711 PF05167.7 ESA10612.1 - 0.064 11.9 0.6 0.34 9.5 0.0 2.2 2 1 1 3 3 3 0 Uncharacterised ACR (DUF711) Nfu_N PF08712.6 ESA10612.1 - 0.086 12.4 0.0 25 4.5 0.0 3.4 3 0 0 3 3 3 0 Scaffold protein Nfu/NifU N terminal UPF0058 PF01893.11 ESA10612.1 - 0.18 11.9 3.1 6 6.9 0.0 4.1 4 1 0 4 4 4 0 Uncharacterised protein family UPF0058 DUF2555 PF10742.4 ESA10612.1 - 0.2 11.2 0.1 0.2 11.2 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2555) TPR_6 PF13174.1 ESA10612.1 - 2.4 8.8 27.8 53 4.5 0.0 9.6 10 1 1 11 11 11 0 Tetratricopeptide repeat Ovate PF04844.8 ESA10613.1 - 0.076 12.8 0.4 0.23 11.2 0.3 1.8 1 0 0 1 1 1 0 Transcriptional repressor, ovate Pkinase_Tyr PF07714.12 ESA10614.1 - 2.5e-28 98.8 0.0 2.8e-28 98.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10614.1 - 5.7e-28 97.7 0.1 7.9e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA10614.1 - 4.3e-05 22.6 0.0 5.1e-05 22.3 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA10614.1 - 0.00052 19.1 0.1 0.00056 19.0 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA10614.1 - 0.0091 15.7 0.4 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA10614.1 - 0.0091 15.3 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA10614.1 - 0.045 13.0 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PPR_2 PF13041.1 ESA10615.1 - 1.6e-05 24.7 2.5 0.099 12.6 0.2 4.1 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.15 ESA10615.1 - 0.0059 16.5 5.0 0.88 9.6 0.3 4.4 4 1 0 4 4 4 1 PPR repeat GAD PF02938.9 ESA10615.1 - 0.039 14.0 0.1 0.079 13.1 0.1 1.5 1 0 0 1 1 1 0 GAD domain Nefa_Nip30_N PF10187.4 ESA10616.1 - 4.2e-05 23.6 8.8 0.00059 19.9 0.9 2.6 2 1 1 3 3 3 2 N-terminal domain of NEFA-interacting nuclear protein NIP30 Geminin PF07412.7 ESA10616.1 - 0.0081 15.8 5.1 0.22 11.1 0.4 2.3 1 1 1 2 2 2 2 Geminin SET PF00856.23 ESA10617.1 - 7.8e-09 36.0 0.1 1.5e-08 35.1 0.1 1.4 1 0 0 1 1 1 1 SET domain TPR_12 PF13424.1 ESA10617.1 - 0.00058 19.7 0.4 0.0049 16.7 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat PPR PF01535.15 ESA10617.1 - 0.0013 18.6 0.5 3 8.0 0.0 2.8 2 0 0 2 2 2 2 PPR repeat TPR_2 PF07719.12 ESA10617.1 - 0.014 15.2 0.1 0.73 9.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA10617.1 - 0.028 14.7 0.0 0.25 11.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Leuk-A4-hydro_C PF09127.6 ESA10617.1 - 0.032 13.8 0.1 0.81 9.2 0.0 2.3 2 0 0 2 2 2 0 Leukotriene A4 hydrolase, C-terminal TPR_15 PF13429.1 ESA10617.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10618.1 - 5.3e-16 58.0 7.3 8.4e-15 54.1 0.7 2.1 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESA10618.1 - 3.4e-09 35.9 7.0 0.0035 17.1 0.2 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA10618.1 - 1.9e-06 28.0 1.6 0.014 15.7 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA10618.1 - 3.1e-06 26.9 3.3 0.0059 16.7 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10618.1 - 3.6e-06 27.5 0.2 0.0028 18.2 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA10618.1 - 1.1e-05 24.7 9.1 0.037 13.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA10618.1 - 3.5e-05 23.8 2.9 6.1e-05 23.0 2.0 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.1 ESA10618.1 - 0.016 15.2 0.1 0.11 12.6 0.0 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA10618.1 - 0.056 14.1 0.1 3.6 8.5 0.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA10618.1 - 0.23 11.3 2.0 2 8.3 0.1 2.7 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat HAUS-augmin3 PF14932.1 ESA10619.1 - 0.036 13.2 1.0 0.042 13.0 0.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF3293 PF11697.3 ESA10619.1 - 0.15 12.2 0.2 3 8.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3293) Pkinase_Tyr PF07714.12 ESA10621.1 - 5.2e-36 124.0 0.0 8.4e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10621.1 - 9.2e-34 116.7 0.1 1.7e-33 115.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA10621.1 - 1.4e-13 50.9 1.5 0.00014 22.3 0.5 4.5 4 0 0 4 4 4 2 Sel1 repeat Sel1 PF08238.7 ESA10622.1 - 4.8e-17 61.9 10.1 4.2e-08 33.5 0.0 3.4 3 0 0 3 3 3 2 Sel1 repeat TPR_19 PF14559.1 ESA10622.1 - 0.0033 17.7 0.5 1.7 9.0 0.2 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10622.1 - 0.0042 17.7 0.6 0.049 14.3 0.0 2.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA10622.1 - 0.057 13.9 4.7 3.1 8.4 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10622.1 - 0.4 10.3 7.0 0.52 9.9 0.1 3.4 3 1 0 3 3 3 0 TPR repeat TPR_1 PF00515.23 ESA10622.1 - 0.63 9.7 14.0 0.68 9.6 0.3 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA10622.1 - 2.3 8.2 5.1 5.5 7.0 0.1 3.5 2 2 2 4 4 4 0 Tetratricopeptide repeat Toxin_R_bind_C PF07951.7 ESA10623.1 - 0.005 16.5 3.4 0.0065 16.1 2.4 1.3 1 0 0 1 1 1 1 Clostridium neurotoxin, C-terminal receptor binding TUSC2 PF15000.1 ESA10623.1 - 0.15 12.1 0.5 1 9.4 0.0 2.4 2 1 0 2 2 2 0 Tumour suppressor candidate 2 RVP_2 PF08284.6 ESA10624.1 - 0.00037 20.4 0.1 0.00053 19.9 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF3090 PF11290.3 ESA10624.1 - 0.017 14.5 0.4 0.019 14.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) DUF1789 PF08748.6 ESA10624.1 - 0.033 14.2 1.4 0.04 14.0 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1789) RXT2_N PF08595.6 ESA10624.1 - 0.06 13.1 3.2 0.074 12.8 2.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal PBP_sp32 PF07222.7 ESA10624.1 - 0.12 11.5 2.7 0.13 11.3 1.9 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Sel1 PF08238.7 ESA10626.1 - 9.6e-57 188.1 33.9 3.6e-12 46.4 0.5 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_11 PF13414.1 ESA10626.1 - 0.00087 18.8 26.9 0.038 13.6 1.4 4.6 2 1 3 5 5 5 4 TPR repeat TPR_17 PF13431.1 ESA10626.1 - 0.043 14.0 20.9 2.9 8.3 0.2 5.1 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA10626.1 - 0.12 12.8 12.4 1.6 9.3 0.6 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat AdoMet_MTase PF07757.8 ESA10626.1 - 0.29 11.2 5.4 1.8 8.6 0.2 3.2 1 1 2 3 3 3 0 Predicted AdoMet-dependent methyltransferase TPR_16 PF13432.1 ESA10626.1 - 1 10.1 10.8 14 6.5 0.0 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA10626.1 - 1.1 9.3 26.1 3.5 7.6 0.6 7.1 5 3 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA10626.1 - 1.2 9.0 27.5 0.48 10.3 0.3 5.2 2 1 3 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ESA10626.1 - 7.2 6.6 10.5 1.9 8.5 0.4 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA10626.1 - 7.9 6.4 25.0 5.9 6.8 1.9 5.3 1 1 5 6 6 6 0 Tetratricopeptide repeat AA_permease_2 PF13520.1 ESA10627.1 - 4.6e-62 209.9 51.2 6.1e-62 209.5 35.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA10627.1 - 3.9e-45 154.1 50.5 7.6e-45 153.1 35.0 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.1 ESA10627.1 - 2.8e-11 43.0 2.6 2.8e-11 43.0 1.8 3.3 4 0 0 4 4 4 1 C-terminus of AA_permease Chordopox_A13L PF05961.6 ESA10627.1 - 5.6 6.9 11.3 7.6 6.5 0.0 3.3 3 0 0 3 3 3 0 Chordopoxvirus A13L protein Acatn PF13000.2 ESA10628.1 - 1.3e-151 505.8 32.5 5.5e-81 272.7 10.1 3.1 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 MRP-S22 PF10245.4 ESA10629.1 - 0.016 14.5 0.8 0.028 13.8 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S22 TLD PF07534.11 ESA10630.1 - 7.6e-06 25.9 3.8 1.6e-05 24.9 2.6 1.5 1 1 0 1 1 1 1 TLD Med27 PF11571.3 ESA10631.1 - 0.01 15.9 8.1 1.1 9.4 0.7 3.2 4 0 0 4 4 4 0 Mediator complex subunit 27 Ribosomal_S6 PF01250.12 ESA10631.1 - 0.044 13.6 4.8 1.5 8.7 0.2 2.6 2 0 0 2 2 2 0 Ribosomal protein S6 THF_DHG_CYH PF00763.18 ESA10631.1 - 0.057 13.4 1.3 14 5.7 0.0 3.0 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain TraT PF05818.7 ESA10631.1 - 0.12 11.7 3.7 4.3 6.6 0.2 2.6 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein zf-3CxxC PF13695.1 ESA10631.1 - 0.39 10.9 12.5 3.2 8.0 1.2 3.1 2 2 0 2 2 2 0 Zinc-binding domain DUF4231 PF14015.1 ESA10631.1 - 0.72 9.8 2.6 11 6.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Iron_traffic PF04362.9 ESA10631.1 - 1.4 8.4 14.0 7.8 6.0 0.3 3.5 3 0 0 3 3 3 0 Bacterial Fe(2+) trafficking zf-H2C2_5 PF13909.1 ESA10631.1 - 3.5 8.0 14.5 7.3 7.0 2.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain HTH_Tnp_1_2 PF13022.1 ESA10631.1 - 3.7 7.3 7.8 11 5.8 0.2 3.3 3 0 0 3 3 3 0 Helix-turn-helix of insertion element transposase Pyocin_S PF06958.7 ESA10632.1 - 0.072 13.4 2.5 0.088 13.1 1.7 1.2 1 0 0 1 1 1 0 S-type Pyocin SAP PF02037.22 ESA10633.1 - 2.5e-10 39.5 0.9 3.6e-10 39.0 0.1 1.7 2 0 0 2 2 2 1 SAP domain DUF641 PF04859.7 ESA10634.1 - 0.0091 15.7 1.1 0.0096 15.6 0.8 1.0 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) DUF972 PF06156.8 ESA10634.1 - 0.016 15.5 2.7 0.018 15.3 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Hormone_1 PF00103.15 ESA10634.1 - 0.017 14.4 2.0 0.018 14.3 1.4 1.0 1 0 0 1 1 1 0 Somatotropin hormone family KLRAQ PF10205.4 ESA10634.1 - 0.04 13.9 1.7 0.05 13.6 1.2 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Seadorna_VP6 PF07407.6 ESA10634.1 - 0.066 11.9 0.5 0.059 12.1 0.3 1.0 1 0 0 1 1 1 0 Seadornavirus VP6 protein IncA PF04156.9 ESA10634.1 - 0.097 12.2 2.6 0.11 12.1 1.8 1.1 1 0 0 1 1 1 0 IncA protein MHC_I_C PF06623.6 ESA10634.1 - 0.14 11.6 0.3 0.19 11.2 0.2 1.2 1 0 0 1 1 1 0 MHC_I C-terminus HALZ PF02183.13 ESA10634.1 - 0.2 11.4 3.7 0.18 11.5 1.7 1.7 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF1875 PF08961.5 ESA10634.1 - 0.26 10.5 3.8 0.48 9.7 2.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1875) NYD-SP28_assoc PF14775.1 ESA10634.1 - 0.32 10.7 2.1 0.46 10.2 1.0 1.7 1 1 0 1 1 1 0 Sperm tail C-terminal domain DUF904 PF06005.7 ESA10634.1 - 1.2 9.4 6.5 2 8.7 4.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DivIC PF04977.10 ESA10634.1 - 1.9 8.0 7.8 2.7 7.5 4.8 1.7 1 1 1 2 2 2 0 Septum formation initiator NUDIX PF00293.23 ESA10635.1 - 1.4e-06 28.0 0.0 2.2e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain A_deaminase PF00962.17 ESA10636.1 - 5.4e-44 150.4 0.1 6.8e-44 150.1 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase FGGY_C PF02782.11 ESA10637.1 - 2e-72 242.9 0.5 3.7e-72 242.1 0.2 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 ESA10637.1 - 5e-71 238.8 0.1 6.8e-71 238.4 0.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DIOX_N PF14226.1 ESA10638.1 - 1e-28 100.1 0.2 1.7e-28 99.5 0.1 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESA10638.1 - 1.3e-21 76.7 0.0 2e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF382 PF04037.8 ESA10640.1 - 1.2e-62 209.4 1.6 2.5e-62 208.4 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.11 ESA10640.1 - 9.1e-23 79.3 8.3 1.7e-22 78.5 5.7 1.5 1 0 0 1 1 1 1 PSP NST1 PF13945.1 ESA10641.1 - 0.013 15.5 12.7 0.015 15.3 8.8 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF3628 PF12300.3 ESA10641.1 - 0.06 13.3 0.8 0.063 13.3 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) DUF1168 PF06658.7 ESA10641.1 - 0.072 12.6 14.6 0.085 12.3 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Neuregulin PF02158.10 ESA10641.1 - 0.15 10.8 6.0 0.16 10.7 4.1 1.0 1 0 0 1 1 1 0 Neuregulin family Protocadherin PF08374.6 ESA10641.1 - 0.4 10.2 8.7 0.43 10.1 6.0 1.1 1 0 0 1 1 1 0 Protocadherin tRNA-synt_2c PF01411.14 ESA10641.1 - 0.49 8.6 5.5 0.57 8.4 3.8 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (A) DUF3807 PF12720.2 ESA10641.1 - 0.7 10.0 12.1 0.72 9.9 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SEEEED PF14797.1 ESA10641.1 - 1.2 9.2 17.0 1.6 8.8 11.8 1.1 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex CKAP2_C PF15297.1 ESA10641.1 - 1.4 7.6 14.1 1.5 7.5 9.8 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus FLO_LFY PF01698.11 ESA10641.1 - 2.2 7.0 11.8 2.3 6.9 8.2 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein GLE1 PF07817.8 ESA10641.1 - 2.4 7.0 8.7 2.9 6.7 6.0 1.1 1 0 0 1 1 1 0 GLE1-like protein ARF7EP_C PF14949.1 ESA10641.1 - 2.5 8.5 7.3 3.1 8.2 5.0 1.2 1 0 0 1 1 1 0 ARF7 effector protein C-terminus Peptidase_S49_N PF08496.5 ESA10641.1 - 2.9 7.6 8.4 3.2 7.5 5.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GAGA_bind PF06217.7 ESA10641.1 - 3 7.7 12.5 3.1 7.6 8.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Vfa1 PF08432.5 ESA10641.1 - 3.5 7.6 14.8 3.8 7.5 10.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Asp-B-Hydro_N PF05279.6 ESA10641.1 - 4.3 7.1 14.1 4.8 6.9 9.8 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RR_TM4-6 PF06459.7 ESA10641.1 - 8.4 6.2 11.8 9.3 6.0 8.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PLDc_N PF13396.1 ESA10642.1 - 9.6e-11 41.1 2.9 1.4e-10 40.6 2.0 1.3 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal AA_permease_2 PF13520.1 ESA10642.1 - 0.021 13.3 1.0 0.023 13.2 0.7 1.0 1 0 0 1 1 1 0 Amino acid permease DUF1443 PF07280.6 ESA10642.1 - 0.044 13.3 0.5 0.43 10.1 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1443) Sel1 PF08238.7 ESA10643.1 - 1.6e-29 101.6 3.1 2.5e-08 34.3 0.0 4.5 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA10643.1 - 0.01 16.2 1.0 19 6.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat AdoMet_MTase PF07757.8 ESA10643.1 - 0.034 14.2 0.1 2.9 8.0 0.0 2.9 1 1 2 3 3 3 0 Predicted AdoMet-dependent methyltransferase MIT PF04212.13 ESA10643.1 - 0.059 13.2 8.1 9.9 6.1 0.5 3.8 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA10643.1 - 0.13 11.9 12.0 2.1 8.0 3.7 3.8 1 1 2 3 3 3 0 TPR repeat Rad33 PF08730.5 ESA10645.1 - 4.8e-05 22.9 2.7 0.00013 21.5 1.9 1.7 1 1 0 1 1 1 1 Rad33 zf-CCHC PF00098.18 ESA10645.1 - 0.06 13.3 1.9 0.06 13.3 1.3 1.8 2 0 0 2 2 2 0 Zinc knuckle Colicin_D PF11429.3 ESA10645.1 - 0.082 13.0 0.2 21 5.3 0.0 2.6 2 0 0 2 2 2 0 Colicin D zf-CCHC_4 PF14392.1 ESA10645.1 - 0.16 11.7 1.0 0.71 9.5 0.4 2.2 2 0 0 2 2 2 0 Zinc knuckle TLD PF07534.11 ESA10647.1 - 2.5e-12 46.9 0.8 5.4e-12 45.8 0.6 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA10647.1 - 9.5e-07 28.6 1.9 0.00025 20.8 0.2 3.1 1 1 2 3 3 3 2 BTB And C-terminal Kelch Sel1 PF08238.7 ESA10649.1 - 1.1e-44 149.8 17.2 3.4e-10 40.2 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA10649.1 - 8e-06 25.6 10.8 0.065 13.1 0.0 4.4 3 1 1 4 4 4 3 MIT (microtubule interacting and transport) domain Trep_dent_lipo PF09710.5 ESA10649.1 - 0.017 13.8 0.3 0.017 13.8 0.2 1.7 2 0 0 2 2 2 0 Treponema clustered lipoprotein (Trep_dent_lipo) NSF PF02071.15 ESA10649.1 - 0.031 14.7 6.9 1.1e+02 4.1 0.1 6.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_11 PF13414.1 ESA10649.1 - 4.1 7.1 24.6 2.4 7.8 1.4 5.2 1 1 4 5 5 5 0 TPR repeat SPA PF08616.5 ESA10650.1 - 4.8e-37 126.1 0.0 9.4e-37 125.1 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.7 ESA10650.1 - 3.1e-17 62.9 0.0 3.1e-17 62.9 0.0 2.6 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2347 PF09804.4 ESA10650.1 - 4.9e-07 29.3 4.1 9.8e-07 28.3 0.0 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) 60KD_IMP PF02096.15 ESA10651.1 - 2.4e-37 128.5 7.0 3.6e-37 127.9 4.9 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein DUF2551 PF10826.3 ESA10653.1 - 0.037 13.9 0.2 0.055 13.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2551) Pkinase_Tyr PF07714.12 ESA10655.1 - 0.0004 19.5 0.0 0.00055 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4028 PF13220.1 ESA10656.1 - 2.7 7.7 5.2 0.32 10.6 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) MBOAT_2 PF13813.1 ESA10659.1 - 9.5e-11 41.6 3.1 2e-10 40.5 2.1 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family TRAPPC10 PF12584.3 ESA10660.1 - 0.074 12.5 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 zf-C2H2_4 PF13894.1 ESA10661.1 - 0.014 15.6 0.4 0.05 13.9 0.2 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met2 PF12907.2 ESA10661.1 - 0.019 14.9 0.9 0.019 14.9 0.6 1.9 2 0 0 2 2 2 0 Zinc-binding zf-C2H2 PF00096.21 ESA10661.1 - 0.02 15.2 0.4 0.073 13.4 0.3 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type Kri1 PF05178.7 ESA10662.1 - 7.6 6.8 8.5 0.34 11.1 0.3 2.6 2 1 0 2 2 2 0 KRI1-like family Fcf2 PF08698.6 ESA10663.1 - 0.014 15.3 2.4 0.017 15.0 1.6 1.2 1 0 0 1 1 1 0 Fcf2 pre-rRNA processing Adenine_glyco PF03352.8 ESA10663.1 - 0.02 14.4 0.9 0.025 14.1 0.7 1.2 1 0 0 1 1 1 0 Methyladenine glycosylase Cluap1 PF10234.4 ESA10663.1 - 0.041 13.0 0.3 0.047 12.8 0.2 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 His_binding PF02098.11 ESA10663.1 - 0.14 11.9 2.5 0.38 10.5 1.7 1.6 1 1 1 2 2 2 0 Tick histamine binding protein Pkinase PF00069.20 ESA10664.1 - 1.1e-17 64.0 2.9 2.6e-17 62.8 2.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10664.1 - 3.3e-16 59.1 0.0 4.4e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA10664.1 - 0.072 12.8 0.2 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cript PF10235.4 ESA10664.1 - 0.25 11.6 5.8 1 9.7 1.3 2.4 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT DUF3684 PF12449.3 ESA10665.1 - 1.8e-32 111.9 1.8 2.5e-10 38.6 0.0 3.5 2 1 2 4 4 4 3 Protein of unknown function (DUF3684) WLM PF08325.5 ESA10665.1 - 0.016 15.1 1.4 0.047 13.5 1.0 1.8 1 0 0 1 1 1 0 WLM domain adh_short_C2 PF13561.1 ESA10665.1 - 0.13 11.9 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RhoGAP PF00620.22 ESA10666.1 - 8e-33 113.2 0.0 1.1e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.1 ESA10666.1 - 1.4e-31 109.3 1.4 2.3e-31 108.6 0.2 1.9 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 ESA10666.1 - 5.7e-06 25.9 0.1 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain RRM_1 PF00076.17 ESA10667.1 - 8.1e-07 28.5 0.5 0.073 12.7 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA10667.1 - 5e-05 23.2 0.0 0.46 10.5 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA10667.1 - 0.00018 21.2 1.9 0.00041 20.1 1.3 1.6 1 0 0 1 1 1 1 Zinc knuckle Methyltransf_FA PF12248.3 ESA10667.1 - 0.041 13.8 0.3 16 5.5 0.2 2.7 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase DUF4283 PF14111.1 ESA10667.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) TrkA_N PF02254.13 ESA10667.1 - 0.14 12.2 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain DUF2972 PF11186.3 ESA10669.1 - 0.059 13.2 2.1 0.086 12.7 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2972) Lipoprotein_X PF03305.8 ESA10669.1 - 0.069 12.5 0.3 0.1 11.9 0.2 1.2 1 0 0 1 1 1 0 Mycoplasma MG185/MG260 protein Pkinase_Tyr PF07714.12 ESA10670.1 - 1.2e-05 24.5 0.0 1.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10670.1 - 0.00054 19.1 0.1 0.0009 18.4 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Basic PF01586.11 ESA10671.1 - 0.16 12.7 0.1 0.27 11.9 0.1 1.4 1 0 0 1 1 1 0 Myogenic Basic domain Slp PF03843.8 ESA10671.1 - 1.1 8.2 3.8 1.6 7.7 2.7 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family GPI-anchored PF10342.4 ESA10672.1 - 3.2e-07 30.7 0.3 1.1e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RRM_6 PF14259.1 ESA10674.1 - 3e-09 36.7 0.1 0.00049 20.0 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA10674.1 - 3.7e-07 29.6 3.6 0.0062 16.1 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA10674.1 - 0.082 12.7 0.4 4.5 7.1 0.1 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA10674.1 - 0.69 9.9 3.7 1.4 9.0 2.6 1.5 1 0 0 1 1 1 0 Zinc knuckle BEX PF04538.7 ESA10675.1 - 0.027 14.6 3.7 0.034 14.3 2.3 1.3 1 1 0 1 1 1 0 Brain expressed X-linked like family Pkinase_Tyr PF07714.12 ESA10676.1 - 0.041 12.9 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase RRM_3 PF08777.6 ESA10676.1 - 0.11 12.4 2.6 4.3 7.2 0.2 2.2 1 1 0 2 2 2 0 RNA binding motif zf-B_box PF00643.19 ESA10676.1 - 0.36 10.7 2.5 0.67 9.8 1.7 1.4 1 0 0 1 1 1 0 B-box zinc finger Ribosomal_S2 PF00318.15 ESA10676.1 - 0.85 8.7 4.6 3 7.0 3.2 1.9 1 1 0 1 1 1 0 Ribosomal protein S2 GCN5L1 PF06320.8 ESA10677.1 - 6.4e-38 129.2 7.6 7.9e-38 129.0 5.2 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) ISG65-75 PF11727.3 ESA10677.1 - 0.0033 16.5 2.3 0.0046 16.0 1.6 1.1 1 0 0 1 1 1 1 Invariant surface glycoprotein AAA_13 PF13166.1 ESA10677.1 - 0.0034 15.9 3.4 0.0037 15.7 2.4 1.1 1 0 0 1 1 1 1 AAA domain Tweety PF04906.8 ESA10677.1 - 0.062 11.7 1.7 0.076 11.4 1.2 1.1 1 0 0 1 1 1 0 Tweety MRP-S31 PF15433.1 ESA10677.1 - 0.11 11.9 3.3 0.11 11.8 2.3 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 AAA_32 PF13654.1 ESA10677.1 - 0.12 11.0 4.8 0.14 10.7 3.3 1.0 1 0 0 1 1 1 0 AAA domain DUF4337 PF14235.1 ESA10677.1 - 0.48 10.2 4.5 0.64 9.8 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Atg14 PF10186.4 ESA10677.1 - 0.71 8.7 6.6 0.84 8.5 4.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 YicC_N PF03755.8 ESA10677.1 - 0.74 9.7 5.6 1 9.2 3.4 1.5 1 1 0 1 1 1 0 YicC-like family, N-terminal region Snf7 PF03357.16 ESA10677.1 - 1.4 8.2 9.1 2.9 7.2 6.3 1.5 1 1 0 1 1 1 0 Snf7 YtxH PF12732.2 ESA10677.1 - 2.4 8.5 4.6 16 5.9 3.2 2.1 1 1 0 1 1 1 0 YtxH-like protein PALP PF00291.20 ESA10678.1 - 1e-46 159.6 0.0 1.3e-46 159.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 ESA10678.1 - 2.1e-18 65.8 0.0 5.3e-11 42.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain SpoIIID PF12116.3 ESA10678.1 - 0.096 12.6 0.0 0.38 10.7 0.0 2.1 2 0 0 2 2 2 0 Stage III sporulation protein D Pga1 PF10333.4 ESA10679.1 - 0.92 9.1 4.4 3.7 7.1 3.1 2.0 1 1 0 1 1 1 0 GPI-Mannosyltransferase II co-activator GTP_EFTU PF00009.22 ESA10680.1 - 1.8e-57 193.8 0.0 3e-57 193.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESA10680.1 - 6.8e-38 128.8 0.0 1.6e-37 127.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 ESA10680.1 - 1.5e-15 57.0 2.0 1.5e-15 57.0 1.4 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA10680.1 - 0.00049 20.0 0.3 0.0015 18.4 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.1 ESA10680.1 - 0.0072 15.9 2.3 0.0072 15.9 1.6 2.7 2 1 1 3 3 3 1 Elongation factor Tu domain 4 Ribosomal_S5 PF00333.15 ESA10680.1 - 0.028 14.1 0.1 0.93 9.2 0.0 2.7 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain Sec20 PF03908.8 ESA10681.1 - 0.14 11.8 0.5 0.27 10.9 0.3 1.5 1 0 0 1 1 1 0 Sec20 DUF3671 PF12420.3 ESA10681.1 - 1.4 8.9 5.4 0.69 9.9 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function FTH PF01827.22 ESA10682.1 - 0.015 14.9 0.3 0.018 14.6 0.2 1.3 1 0 0 1 1 1 0 FTH domain Hydrolase_like PF13242.1 ESA10683.1 - 2.5e-16 59.1 0.0 3.5e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 ESA10683.1 - 5.7e-05 23.6 0.0 6.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.20 ESA10685.1 - 3.8e-60 203.2 0.0 5.6e-41 140.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10685.1 - 1.3e-26 93.2 0.0 1.6e-20 73.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 ESA10685.1 - 3e-05 24.4 0.9 5.4e-05 23.6 0.7 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.9 ESA10685.1 - 0.00052 19.1 0.2 0.0014 17.7 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA10685.1 - 0.0014 17.6 0.0 0.0038 16.2 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 ESA10685.1 - 0.0024 17.6 2.0 0.015 15.0 0.1 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESA10685.1 - 0.003 16.4 0.2 0.0049 15.7 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Seadorna_VP7 PF07387.6 ESA10685.1 - 0.025 13.4 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.17 ESA10685.1 - 0.13 11.6 0.0 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Myb_DNA-bind_6 PF13921.1 ESA10686.1 - 3.8e-07 30.1 0.1 8.9e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA10686.1 - 2.8e-05 24.0 0.1 5.2e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain A2M_recep PF07677.9 ESA10686.1 - 0.11 12.6 0.3 0.29 11.3 0.2 1.6 1 0 0 1 1 1 0 A-macroglobulin receptor IFN-gamma PF00714.12 ESA10687.1 - 0.071 12.9 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Interferon gamma HTH_7 PF02796.10 ESA10689.1 - 0.0053 16.5 0.2 1 9.3 0.0 2.1 2 0 0 2 2 2 2 Helix-turn-helix domain of resolvase Fe_dep_repress PF01325.14 ESA10689.1 - 0.054 13.4 0.1 0.089 12.7 0.0 1.4 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.7 ESA10689.1 - 0.074 12.7 0.2 1.2 8.8 0.0 2.0 2 0 0 2 2 2 0 HTH domain TrmB PF01978.14 ESA10689.1 - 0.11 12.1 0.2 1.4 8.6 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Luciferase_N PF05295.6 ESA10690.1 - 0.0028 17.4 0.3 0.0076 16.0 0.1 1.8 2 0 0 2 2 2 1 Luciferase/LBP N-terminal domain VWA_3 PF13768.1 ESA10690.1 - 0.059 13.0 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Wzy_C PF04932.10 ESA10692.1 - 0.051 13.3 5.2 0.11 12.3 3.6 1.6 1 0 0 1 1 1 0 O-Antigen ligase Big_5 PF13205.1 ESA10692.1 - 0.091 13.3 0.1 0.19 12.3 0.1 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain Rifin_STEVOR PF02009.11 ESA10692.1 - 0.098 12.2 0.4 0.16 11.5 0.3 1.4 1 0 0 1 1 1 0 Rifin/stevor family DUF3671 PF12420.3 ESA10692.1 - 1.3 9.0 12.2 0.098 12.6 4.6 2.1 2 0 0 2 2 2 0 Protein of unknown function MRG PF05712.8 ESA10694.1 - 2.1e-42 144.2 1.9 3e-42 143.7 1.4 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 ESA10694.1 - 8.1e-05 22.2 3.3 8.1e-05 22.2 2.3 2.6 3 1 0 3 3 3 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 ESA10694.1 - 0.00051 19.6 0.5 0.0016 18.0 0.3 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain BTB PF00651.26 ESA10696.1 - 3.2e-15 56.0 0.1 7.3e-15 54.9 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Bromodomain PF00439.20 ESA10697.1 - 5e-17 61.6 0.8 5.5e-17 61.4 0.5 1.0 1 0 0 1 1 1 1 Bromodomain S_layer_N PF05123.7 ESA10698.1 - 6.1 6.3 7.0 2.5 7.6 1.6 2.0 2 0 0 2 2 2 0 S-layer like family, N-terminal region MCRS_N PF13325.1 ESA10699.1 - 0.048 13.1 1.3 0.054 13.0 0.9 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Scm3 PF10384.4 ESA10699.1 - 0.053 13.0 0.5 0.098 12.1 0.4 1.5 1 0 0 1 1 1 0 Centromere protein Scm3 LAGLIDADG_WhiA PF14527.1 ESA10699.1 - 0.15 11.9 0.7 0.26 11.1 0.3 1.6 1 1 1 2 2 2 0 WhiA LAGLIDADG-like domain PRESAN PF09687.5 ESA10699.1 - 0.32 11.0 8.0 0.63 10.1 5.6 1.5 1 1 0 1 1 1 0 Plasmodium RESA N-terminal Endotoxin_M PF00555.14 ESA10700.1 - 6.5 6.5 12.5 0.26 11.0 2.5 2.5 3 0 0 3 3 3 0 delta endotoxin DUF912 PF06024.7 ESA10700.1 - 6.7 6.8 7.9 1.5 8.9 1.9 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CENP-F_leu_zip PF10473.4 ESA10701.1 - 0.01 15.6 0.2 0.011 15.5 0.1 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4047 PF13256.1 ESA10701.1 - 0.039 13.9 1.3 0.045 13.7 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) DZR PF12773.2 ESA10701.1 - 0.075 12.8 1.8 0.12 12.2 1.3 1.2 1 0 0 1 1 1 0 Double zinc ribbon V-SNARE PF05008.10 ESA10701.1 - 0.14 12.3 0.4 0.27 11.4 0.3 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus CpXC PF14353.1 ESA10701.1 - 0.17 11.8 5.1 0.31 11.0 3.5 1.5 1 1 0 1 1 1 0 CpXC protein zinc_ribbon_6 PF14599.1 ESA10701.1 - 3.9 7.3 7.5 1.2 8.9 2.3 1.9 2 0 0 2 2 2 0 Zinc-ribbon CorA PF01544.13 ESA10702.1 - 0.0024 16.9 5.6 0.0032 16.5 3.9 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Prominin PF05478.6 ESA10702.1 - 0.0032 15.0 1.2 0.0038 14.8 0.8 1.2 1 0 0 1 1 1 1 Prominin DUF106 PF01956.11 ESA10702.1 - 0.0043 16.6 0.3 0.0079 15.7 0.2 1.4 1 0 0 1 1 1 1 Integral membrane protein DUF106 DUF3921 PF13060.1 ESA10702.1 - 0.0073 16.1 0.6 0.017 14.9 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3921) DUF1917 PF08939.5 ESA10702.1 - 0.0086 15.8 0.1 0.014 15.1 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1917) Spc7 PF08317.6 ESA10702.1 - 0.0093 14.6 10.0 0.011 14.3 6.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Fib_alpha PF08702.5 ESA10702.1 - 0.01 15.9 5.2 0.013 15.6 3.6 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Sec20 PF03908.8 ESA10702.1 - 0.016 14.9 2.3 0.021 14.5 0.4 2.0 1 1 1 2 2 2 0 Sec20 DivIVA PF05103.8 ESA10702.1 - 0.034 14.2 7.5 0.042 13.9 5.2 1.2 1 0 0 1 1 1 0 DivIVA protein Sec62 PF03839.11 ESA10702.1 - 0.034 13.5 1.1 0.044 13.1 0.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PhoH PF02562.11 ESA10702.1 - 0.038 13.2 0.8 0.051 12.8 0.6 1.2 1 0 0 1 1 1 0 PhoH-like protein IZUMO PF15005.1 ESA10702.1 - 0.047 13.7 4.9 0.064 13.3 3.4 1.2 1 0 0 1 1 1 0 Izumo sperm-egg fusion DUF4071 PF13281.1 ESA10702.1 - 0.059 12.2 6.6 0.098 11.4 4.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4071) AAA_13 PF13166.1 ESA10702.1 - 0.062 11.7 10.4 0.072 11.5 7.2 1.0 1 0 0 1 1 1 0 AAA domain DUF2207 PF09972.4 ESA10702.1 - 0.081 11.4 2.3 0.096 11.2 1.1 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Stap_Strp_tox_C PF02876.12 ESA10702.1 - 0.14 12.3 4.1 0.2 11.7 2.8 1.2 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain DPM3 PF08285.6 ESA10702.1 - 0.17 11.7 0.3 0.17 11.7 0.2 2.9 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CagE_TrbE_VirB PF03135.9 ESA10702.1 - 0.26 11.0 4.7 0.26 11.0 2.5 1.4 1 1 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Tweety PF04906.8 ESA10702.1 - 0.28 9.5 3.2 0.27 9.6 0.9 1.6 1 1 0 1 1 1 0 Tweety DUF1664 PF07889.7 ESA10702.1 - 0.29 10.9 7.6 1 9.1 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PilJ PF13675.1 ESA10702.1 - 0.31 11.3 3.2 0.54 10.5 2.2 1.4 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF342 PF03961.8 ESA10702.1 - 0.37 9.1 6.0 0.42 8.9 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF972 PF06156.8 ESA10702.1 - 0.37 11.1 6.0 0.57 10.5 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TMF_TATA_bd PF12325.3 ESA10702.1 - 0.45 10.2 10.3 0.71 9.6 7.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF3407 PF11887.3 ESA10702.1 - 0.49 9.6 2.9 0.62 9.3 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3407) GrpE PF01025.14 ESA10702.1 - 0.87 9.1 7.6 1.7 8.1 5.3 1.7 1 1 0 1 1 1 0 GrpE DUF745 PF05335.8 ESA10702.1 - 0.94 8.9 7.0 2.9 7.3 4.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Med9 PF07544.8 ESA10702.1 - 1 9.1 8.1 1 9.1 2.8 2.5 1 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Baculo_p24 PF05073.7 ESA10702.1 - 1.6 8.2 10.2 3.6 7.1 7.1 1.7 1 1 0 1 1 1 0 Baculovirus P24 capsid protein Pex24p PF06398.6 ESA10702.1 - 4.7 5.9 9.5 0.17 10.6 1.5 2.0 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin GP41 PF00517.12 ESA10702.1 - 5 6.6 14.4 4.8 6.6 5.5 2.5 1 1 1 2 2 2 0 Retroviral envelope protein V_ATPase_I PF01496.14 ESA10702.1 - 6.1 4.5 11.7 0.53 8.0 5.1 1.4 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.7 ESA10702.1 - 7.3 6.3 10.7 12 5.5 7.1 1.6 1 1 0 1 1 1 0 Laminin Domain II DUF3391 PF11871.3 ESA10705.1 - 0.067 13.4 0.5 0.067 13.4 0.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) FUSC-like PF12805.2 ESA10705.1 - 0.085 11.7 0.1 0.085 11.7 0.1 2.5 3 0 0 3 3 3 0 FUSC-like inner membrane protein yccS Baculo_PEP_C PF04513.7 ESA10705.1 - 1.6 8.5 11.5 40 4.0 4.7 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med9 PF07544.8 ESA10705.1 - 2.3 8.0 13.5 1.7 8.4 0.6 3.9 2 2 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 HLH PF00010.21 ESA10708.1 - 3e-11 42.8 0.4 3e-11 42.8 0.3 2.7 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain LolA PF03548.10 ESA10709.1 - 0.019 14.5 0.1 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA DUF788 PF05620.6 ESA10709.1 - 0.06 13.2 0.1 0.066 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Sel1 PF08238.7 ESA10710.1 - 7.5e-54 178.9 39.1 1e-09 38.6 1.0 8.5 8 1 0 8 8 8 7 Sel1 repeat TPR_6 PF13174.1 ESA10710.1 - 6.6e-07 29.3 10.6 0.93 10.0 0.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat SinI PF08671.5 ESA10710.1 - 0.041 13.3 0.1 9.7 5.7 0.0 3.2 3 0 0 3 3 3 0 Anti-repressor SinI Sel1 PF08238.7 ESA10712.1 - 9.2e-67 220.0 37.7 3.1e-10 40.3 2.7 11.1 11 0 0 11 11 11 11 Sel1 repeat TPR_11 PF13414.1 ESA10712.1 - 0.11 12.1 27.3 0.57 9.8 4.3 5.9 3 3 4 7 7 7 0 TPR repeat TPR_6 PF13174.1 ESA10712.1 - 0.25 11.8 10.9 4 8.1 0.1 6.2 8 0 0 8 8 8 0 Tetratricopeptide repeat RasGEF PF00617.14 ESA10713.1 - 1.4e-45 155.3 0.3 2.7e-45 154.3 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESA10713.1 - 2e-17 63.1 1.5 2e-17 63.1 1.0 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif SSP160 PF06933.6 ESA10713.1 - 3.8 5.3 6.4 6.8 4.5 4.4 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SHS2_Rpb7-N PF03876.12 ESA10714.1 - 4.9e-13 49.0 0.2 8.1e-13 48.2 0.1 1.4 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.7 ESA10714.1 - 1.5e-09 38.0 0.0 2.4e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 S1 PF00575.18 ESA10714.1 - 0.005 16.9 0.0 0.008 16.2 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain Beta-Casp PF10996.3 ESA10716.1 - 0.003 17.4 0.0 0.0061 16.5 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain DUF3275 PF11679.3 ESA10717.1 - 0.052 13.1 0.0 0.064 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Sel1 PF08238.7 ESA10718.1 - 8.9e-34 115.1 15.2 1.6e-07 31.7 0.2 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA10718.1 - 0.0091 16.3 4.7 16 6.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 ESA10718.1 - 0.15 11.9 5.0 3.9 7.4 0.1 3.8 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESA10718.1 - 2.8 7.6 0.0 2.8 7.6 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DnaB_2 PF07261.6 ESA10720.1 - 0.071 12.7 0.2 0.095 12.3 0.1 1.3 1 0 0 1 1 1 0 Replication initiation and membrane attachment TLD PF07534.11 ESA10722.1 - 2.8e-15 56.5 4.3 2.8e-15 56.5 0.9 2.2 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA10722.1 - 3.2e-12 46.3 0.0 7e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA10722.1 - 7.8e-06 25.6 3.3 9.6e-05 22.1 0.3 3.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3991 PF13154.1 ESA10724.1 - 0.0028 17.8 0.1 0.0075 16.4 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3991) FTH PF01827.22 ESA10725.1 - 0.0014 18.2 0.5 0.0023 17.5 0.3 1.4 1 1 0 1 1 1 1 FTH domain F-box-like PF12937.2 ESA10727.1 - 7.9e-06 25.5 0.3 1.6e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 F-box-like Plasmid_killer PF05015.8 ESA10727.1 - 0.099 12.7 0.3 0.65 10.1 0.0 2.3 2 1 0 2 2 2 0 Plasmid maintenance system killer protein p450 PF00067.17 ESA10728.1 - 2e-51 174.9 0.0 2.3e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sel1 PF08238.7 ESA10729.1 - 2.8e-165 533.1 82.3 6.6e-11 42.4 0.2 20.1 19 1 1 20 20 20 20 Sel1 repeat TPR_6 PF13174.1 ESA10729.1 - 8.8e-08 32.1 34.6 0.94 10.0 0.1 13.5 16 0 0 16 16 16 4 Tetratricopeptide repeat Sec-ASP3 PF15432.1 ESA10729.1 - 0.26 11.2 5.1 2.4 8.1 0.1 3.4 4 0 0 4 4 4 0 Accessory Sec secretory system ASP3 Sel1 PF08238.7 ESA10730.1 - 7.2e-139 449.2 72.6 8.5e-12 45.3 0.7 15.9 16 0 0 16 16 16 15 Sel1 repeat TPR_6 PF13174.1 ESA10730.1 - 8.4e-09 35.3 22.7 1.4 9.5 0.1 11.0 12 0 0 12 12 12 3 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA10730.1 - 0.21 11.3 4.6 6.4 6.6 0.0 4.2 3 1 2 5 5 5 0 Aurora-A binding TPR_17 PF13431.1 ESA10730.1 - 3.7 7.9 34.7 13 6.2 0.0 10.1 11 1 0 12 12 12 0 Tetratricopeptide repeat Bromodomain PF00439.20 ESA10732.1 - 3e-13 49.4 0.1 3.2e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Bromodomain Ion_trans PF00520.26 ESA10733.1 - 8.4e-07 28.4 17.0 2.2e-06 27.0 11.8 1.8 1 0 0 1 1 1 1 Ion transport protein zf-MYND PF01753.13 ESA10733.1 - 3.1e-05 23.7 4.6 6.9e-05 22.6 3.2 1.6 1 0 0 1 1 1 1 MYND finger Ecl1 PF12855.2 ESA10733.1 - 0.17 11.2 4.7 0.43 9.9 3.3 1.7 1 0 0 1 1 1 0 Life-span regulatory factor V-SNARE PF05008.10 ESA10733.1 - 0.17 12.0 3.1 0.39 10.9 2.1 1.6 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus DUF739 PF05339.6 ESA10734.1 - 0.03 14.1 0.1 5.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF739) VCBS PF13517.1 ESA10736.1 - 1.3e-05 25.4 2.6 0.051 13.9 0.3 4.1 3 1 1 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS2_Mid PF14783.1 ESA10736.1 - 0.00021 21.0 1.3 1.8 8.4 0.0 4.2 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.18 ESA10736.1 - 0.032 13.9 6.3 0.75 9.5 0.3 2.8 3 0 0 3 3 3 0 FG-GAP repeat Ribosomal_S7e PF01251.13 ESA10737.1 - 1.9e-80 268.8 5.3 2.1e-80 268.7 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Clat_adaptor_s PF01217.15 ESA10738.1 - 1.4e-39 135.0 4.9 2.6e-38 130.9 3.4 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Pkinase_Tyr PF07714.12 ESA10740.1 - 1.4e-42 145.6 0.0 1.7e-42 145.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10740.1 - 4.6e-37 127.5 0.0 6.4e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RhoGAP PF00620.22 ESA10741.1 - 2.1e-29 102.0 0.0 5.6e-29 100.7 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain MyTH4 PF00784.12 ESA10741.1 - 3.7e-28 97.7 0.1 2.3e-27 95.2 0.0 2.2 2 0 0 2 2 2 1 MyTH4 domain Sel1 PF08238.7 ESA10742.1 - 2.8e-42 142.1 7.3 4.8e-12 46.0 0.7 5.1 5 0 0 5 5 5 5 Sel1 repeat Eaf7 PF07904.8 ESA10743.1 - 0.12 12.3 3.0 0.16 11.9 2.1 1.3 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 zf-RING_2 PF13639.1 ESA10744.1 - 1e-06 28.4 5.7 1e-06 28.4 4.0 1.8 2 0 0 2 2 2 1 Ring finger domain SWIM PF04434.12 ESA10744.1 - 0.00028 20.2 0.5 0.00056 19.3 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger zf-rbx1 PF12678.2 ESA10744.1 - 0.0033 17.4 3.3 0.0033 17.4 2.3 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA10744.1 - 0.0056 16.6 7.2 0.013 15.4 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 ESA10744.1 - 0.01 15.4 9.6 0.02 14.5 6.7 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.3 ESA10744.1 - 0.013 15.4 6.2 0.013 15.4 4.3 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 ESA10744.1 - 0.022 14.4 4.0 0.049 13.3 2.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 ESA10744.1 - 0.23 11.4 4.0 0.69 9.9 2.8 1.8 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.1 ESA10744.1 - 0.26 10.8 8.5 0.6 9.7 5.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain C1_1 PF00130.17 ESA10744.1 - 0.41 10.4 7.9 0.078 12.7 2.6 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.20 ESA10744.1 - 1.2 8.8 7.3 3.8 7.2 5.0 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA10744.1 - 3.6 7.3 12.8 0.21 11.3 5.0 1.9 2 0 0 2 2 2 0 zinc-RING finger domain RINGv PF12906.2 ESA10744.1 - 4.1 7.5 9.4 9.1 6.4 6.5 1.6 1 0 0 1 1 1 0 RING-variant domain Glyoxalase PF00903.20 ESA10745.1 - 1.6e-24 86.2 1.0 4.1e-15 55.8 0.1 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 ESA10745.1 - 8.2e-13 48.3 0.1 4.3e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.1 ESA10745.1 - 3e-07 30.4 0.1 9.8e-07 28.7 0.0 1.8 2 1 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_2 PF12681.2 ESA10745.1 - 2.2e-06 28.2 0.0 0.037 14.6 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.1 ESA10745.1 - 3.5e-05 23.7 0.0 1.8 8.4 0.0 3.5 3 1 0 3 3 3 3 Glyoxalase-like domain FAR1 PF03101.10 ESA10746.1 - 2.1e-07 31.3 1.9 2.9e-07 30.8 1.3 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain DUF4464 PF14713.1 ESA10746.1 - 0.02 14.2 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4464) DUF2659 PF10858.3 ESA10749.1 - 0.045 13.1 5.4 1.6 8.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2659) N_NLPC_P60 PF12912.2 ESA10749.1 - 0.049 13.7 0.5 0.19 11.7 0.0 2.1 1 1 1 2 2 2 0 NLPC_P60 stabilising domain, N term CemA PF03040.9 ESA10749.1 - 0.5 9.9 3.4 0.75 9.3 2.4 1.3 1 0 0 1 1 1 0 CemA family Pkinase PF00069.20 ESA10751.1 - 9.5e-12 44.6 0.1 1.5e-10 40.7 0.1 2.3 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA10751.1 - 0.00018 20.9 0.2 0.0016 17.8 0.1 2.3 2 1 0 2 2 2 1 RIO1 family APH PF01636.18 ESA10751.1 - 0.0078 15.9 0.2 0.91 9.2 0.2 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Med26 PF08711.6 ESA10751.1 - 0.014 14.8 0.1 1.2 8.6 0.0 2.7 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Pkinase_Tyr PF07714.12 ESA10751.1 - 0.039 13.0 0.1 2.4 7.1 0.1 2.7 2 1 0 2 2 2 0 Protein tyrosine kinase DUF1600 PF07667.6 ESA10752.1 - 0.0038 17.2 0.1 0.0051 16.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1600) ETRAMP PF09716.5 ESA10752.1 - 0.018 15.0 1.3 0.039 13.8 0.9 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4293 PF14126.1 ESA10752.1 - 0.065 13.1 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) Sel1 PF08238.7 ESA10753.1 - 5.4e-34 115.8 10.9 4.3e-10 39.9 0.4 5.1 4 1 1 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA10753.1 - 0.082 12.7 4.1 0.95 9.3 1.0 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain YqgF PF14639.1 ESA10754.1 - 0.015 14.8 2.5 0.021 14.4 0.6 2.0 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 Btz PF09405.5 ESA10754.1 - 0.27 11.2 13.6 11 6.0 9.4 2.6 1 1 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding SYS1 PF09801.4 ESA10755.1 - 3.4e-40 137.3 12.5 3.8e-40 137.2 8.7 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network MrpF_PhaF PF04066.8 ESA10755.1 - 0.66 10.2 5.4 6.1 7.2 0.8 2.4 2 0 0 2 2 2 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) RXT2_N PF08595.6 ESA10758.1 - 0.0052 16.5 3.0 0.012 15.4 2.0 1.6 1 0 0 1 1 1 1 RXT2-like, N-terminal Sporozoite_P67 PF05642.6 ESA10758.1 - 0.025 12.4 5.4 0.035 11.9 3.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nucleoplasmin PF03066.10 ESA10758.1 - 0.11 12.0 5.1 0.2 11.1 3.5 1.5 1 0 0 1 1 1 0 Nucleoplasmin TLP-20 PF06088.6 ESA10758.1 - 0.18 11.5 7.5 0.017 14.7 1.9 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CENP-B_dimeris PF09026.5 ESA10758.1 - 0.18 12.0 8.0 0.36 11.1 5.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.4 ESA10758.1 - 0.42 9.2 12.8 0.82 8.3 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BTB PF00651.26 ESA10761.1 - 7e-18 64.6 0.3 1.6e-17 63.4 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA10761.1 - 1e-15 57.9 2.8 1e-15 57.9 1.9 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA10761.1 - 1.1e-07 31.6 0.2 7.4e-07 28.9 0.1 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch Peptidase_M50 PF02163.17 ESA10762.1 - 7.3e-07 28.3 3.2 9e-06 24.7 2.2 2.2 1 1 0 1 1 1 1 Peptidase family M50 BAR_3_WASP_bdg PF10456.4 ESA10763.1 - 3.9e-27 95.0 3.2 2.6e-26 92.3 2.2 1.9 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.19 ESA10763.1 - 5.5e-24 84.1 0.4 1.3e-23 82.9 0.3 1.7 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.1 ESA10763.1 - 9.2e-12 44.3 0.0 2.3e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 ESA10763.1 - 4.7e-10 38.6 0.0 1e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA10763.1 - 1.8e-07 30.5 0.0 5.4e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Vps5 PF09325.5 ESA10763.1 - 0.018 14.3 1.6 0.03 13.5 0.3 1.9 2 0 0 2 2 2 0 Vps5 C terminal like MreB_Mbl PF06723.8 ESA10764.1 - 0.008 14.8 0.0 0.58 8.6 0.0 2.1 1 1 1 2 2 2 2 MreB/Mbl protein DUF1204 PF06721.6 ESA10765.1 - 0.0029 16.9 4.5 0.0056 15.9 3.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1204) OmpH PF03938.9 ESA10765.1 - 0.028 14.3 31.0 0.3 10.9 5.9 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Androgen_recep PF02166.11 ESA10765.1 - 2.3 6.9 15.1 3.8 6.2 10.4 1.3 1 0 0 1 1 1 0 Androgen receptor Troponin PF00992.15 ESA10765.1 - 3.5 7.6 24.2 0.49 10.4 4.1 3.8 3 1 1 4 4 4 0 Troponin SPX PF03105.14 ESA10765.1 - 7 6.3 26.9 2.8 7.6 5.6 2.4 2 0 0 2 2 2 0 SPX domain IncA PF04156.9 ESA10765.1 - 8.3 5.9 40.4 1.7 8.2 9.5 2.5 3 0 0 3 3 3 0 IncA protein DUF4557 PF15101.1 ESA10765.1 - 8.8 6.1 18.4 0.18 11.5 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) DUF1768 PF08719.6 ESA10766.1 - 5.2e-33 114.0 3.1 2.2e-31 108.7 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1768) Activator_LAG-3 PF11498.3 ESA10766.1 - 0.005 15.6 26.1 0.005 15.6 18.1 2.1 3 0 0 3 3 3 1 Transcriptional activator LAG-3 PARP PF00644.15 ESA10767.1 - 6.3e-13 48.6 6.7 2.5e-10 40.1 4.7 3.1 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain zf-MYND PF01753.13 ESA10768.1 - 1 9.3 21.5 2.2 8.2 4.0 3.9 2 2 0 2 2 2 0 MYND finger DUF329 PF03884.9 ESA10768.1 - 2 8.0 22.8 0.14 11.7 0.8 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF329) DUF581 PF04570.9 ESA10768.1 - 3.2 7.1 10.7 0.5 9.7 0.6 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF581) Ecl1 PF12855.2 ESA10768.1 - 9.5 5.6 14.3 3.9 6.8 1.2 3.9 3 0 0 3 3 3 0 Life-span regulatory factor PDZ_1 PF12812.2 ESA10769.1 - 2.7e-25 88.0 0.0 4.8e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 PDZ-like domain Trypsin_2 PF13365.1 ESA10769.1 - 3.2e-10 40.0 0.0 5.7e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 ESA10769.1 - 1.1e-09 38.0 0.1 2.2e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Trypsin PF00089.21 ESA10769.1 - 0.0011 18.5 0.0 0.002 17.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.4 ESA10769.1 - 0.024 13.0 0.2 0.035 12.5 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.16 ESA10769.1 - 0.065 12.6 0.4 0.14 11.5 0.3 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF31 PF01732.11 ESA10769.1 - 0.12 11.6 0.4 0.18 11.1 0.3 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S3 PF00944.14 ESA10769.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein CENP-B_N PF04218.8 ESA10770.1 - 2.1e-12 46.2 0.4 3.1e-12 45.6 0.3 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain BrkDBD PF09607.5 ESA10770.1 - 6.3e-09 35.2 0.8 1.8e-08 33.8 0.2 1.9 2 0 0 2 2 2 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.15 ESA10770.1 - 7.7e-06 25.7 0.4 1e-05 25.4 0.3 1.2 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.1 ESA10770.1 - 5.4e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA10770.1 - 0.0024 17.4 0.1 0.0042 16.6 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HisG_C PF08029.6 ESA10771.1 - 4.7e-24 84.1 0.0 5e-24 84.0 0.0 1.0 1 0 0 1 1 1 1 HisG, C-terminal domain AroM PF07302.6 ESA10771.1 - 0.052 12.8 0.0 0.055 12.7 0.0 1.0 1 0 0 1 1 1 0 AroM protein Ribosomal_L12 PF00542.14 ESA10771.1 - 0.054 13.5 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Methyltrans_RNA PF04452.9 ESA10771.1 - 0.097 11.7 0.0 0.097 11.7 0.0 1.0 1 0 0 1 1 1 0 RNA methyltransferase Nuc_sug_transp PF04142.10 ESA10772.1 - 4.9e-88 294.3 17.0 7.3e-88 293.7 11.8 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 ESA10772.1 - 6.5e-10 38.4 16.4 6.5e-10 38.4 11.4 1.3 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESA10772.1 - 2.8e-07 30.7 2.8 2.8e-07 30.7 1.9 3.3 3 1 0 3 3 3 1 Multidrug resistance efflux transporter TPT PF03151.11 ESA10772.1 - 6.6e-05 22.6 6.6 6.6e-05 22.6 4.6 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 ESA10772.1 - 0.00019 21.4 4.2 0.00019 21.4 2.9 2.4 2 0 0 2 2 2 1 EamA-like transporter family DUF202 PF02656.10 ESA10772.1 - 0.03 14.5 0.0 0.03 14.5 0.0 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF202) ChaC PF04752.7 ESA10773.1 - 5.4e-63 212.1 0.0 6.2e-63 211.9 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein zf-C3HC4_3 PF13920.1 ESA10774.1 - 0.001 18.6 7.6 0.001 18.6 5.3 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA10774.1 - 0.0047 16.5 10.3 0.0047 16.5 7.1 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 ESA10775.1 - 1.3e-26 93.2 0.0 1.5e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10775.1 - 1.3e-25 89.9 0.0 1.4e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA10775.1 - 0.065 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsbU PF06514.6 ESA10775.1 - 0.075 12.8 0.1 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) PDZ_1 PF12812.2 ESA10777.1 - 1.6e-18 66.3 0.2 1.8e-17 62.9 0.1 2.2 1 1 0 1 1 1 1 PDZ-like domain PDZ_2 PF13180.1 ESA10777.1 - 1.1e-09 38.0 0.0 8.4e-07 28.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain Trypsin_2 PF13365.1 ESA10777.1 - 0.0038 17.2 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S46 PF10459.4 ESA10777.1 - 0.042 12.2 0.1 0.054 11.9 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.16 ESA10777.1 - 0.045 13.1 1.1 0.088 12.2 0.7 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease PDZ PF00595.19 ESA10777.1 - 0.09 12.9 0.2 0.53 10.5 0.0 2.2 2 0 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) DUF31 PF01732.11 ESA10777.1 - 0.14 11.4 0.6 0.2 10.9 0.4 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Homeobox PF00046.24 ESA10779.1 - 1.2e-21 76.0 2.1 2e-21 75.3 1.5 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 ESA10779.1 - 0.003 17.2 0.7 0.0072 16.0 0.2 1.8 1 1 0 1 1 1 1 Homeobox KN domain BACK PF07707.10 ESA10780.1 - 0.0003 20.5 3.7 0.0018 18.1 1.3 2.2 1 1 1 2 2 2 2 BTB And C-terminal Kelch Arc_PepC_II PF06847.6 ESA10782.1 - 0.082 13.3 0.0 0.088 13.2 0.0 1.1 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II AF1Q PF15017.1 ESA10783.1 - 0.0013 18.6 1.2 0.0014 18.5 0.8 1.0 1 0 0 1 1 1 1 Drug resistance and apoptosis regulator DUF4611 PF15387.1 ESA10783.1 - 0.54 10.4 3.4 0.62 10.2 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Pyr_redox_2 PF07992.9 ESA10784.1 - 1.3e-30 106.7 0.1 5.4e-29 101.5 0.1 3.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.17 ESA10784.1 - 4.8e-27 94.2 0.1 8.6e-27 93.4 0.1 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rieske_2 PF13806.1 ESA10784.1 - 2.9e-23 81.5 0.0 1.1e-22 79.6 0.0 2.0 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Pyr_redox PF00070.22 ESA10784.1 - 2.7e-18 66.1 3.4 3.2e-17 62.7 0.3 3.1 4 0 0 4 4 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.10 ESA10784.1 - 4.6e-18 65.0 7.0 5.1e-13 48.8 3.6 2.7 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske PF00355.21 ESA10784.1 - 7.4e-15 54.3 0.1 2e-14 52.8 0.0 1.8 2 0 0 2 2 1 1 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.12 ESA10784.1 - 4.5e-10 39.0 0.0 9.7e-10 37.9 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.1 ESA10784.1 - 1.5e-09 38.1 0.0 7.6e-07 29.3 0.0 3.3 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 ESA10784.1 - 4.1e-08 32.5 1.2 0.034 13.0 0.0 3.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 ESA10784.1 - 6e-07 29.3 0.8 0.99 9.1 0.0 4.2 2 2 2 4 4 4 3 FAD-NAD(P)-binding HI0933_like PF03486.9 ESA10784.1 - 8.9e-06 24.4 0.5 0.19 10.1 0.4 3.2 2 1 1 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.16 ESA10784.1 - 7.2e-05 22.4 0.0 0.0017 17.9 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 ESA10784.1 - 0.00011 22.3 0.1 0.15 12.2 0.0 2.6 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.1 ESA10784.1 - 0.00034 20.5 0.0 0.0059 16.5 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESA10784.1 - 0.00048 19.1 0.1 0.054 12.3 0.1 2.5 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 ESA10784.1 - 0.0011 17.8 1.5 0.022 13.6 0.1 2.3 1 1 0 2 2 2 1 FAD binding domain TrkA_N PF02254.13 ESA10784.1 - 0.0036 17.2 0.1 1.9 8.5 0.1 2.7 2 0 0 2 2 2 1 TrkA-N domain 3HCDH_N PF02737.13 ESA10784.1 - 0.02 14.5 0.1 0.053 13.1 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.14 ESA10784.1 - 0.024 13.6 0.5 0.043 12.8 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.15 ESA10784.1 - 0.037 14.1 0.2 0.13 12.3 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 ESA10784.1 - 0.044 13.8 0.6 0.46 10.4 0.1 2.7 2 1 1 3 3 2 0 NADH(P)-binding RMP PF14996.1 ESA10785.1 - 0.11 12.4 3.4 0.15 11.9 2.3 1.3 1 0 0 1 1 1 0 Retinal Maintenance MTHFR_C PF12225.3 ESA10786.1 - 0.0034 16.8 0.6 0.0096 15.4 0.2 1.9 2 0 0 2 2 2 1 Methylene-tetrahydrofolate reductase C terminal zf-C3HC4_3 PF13920.1 ESA10786.1 - 0.058 13.0 5.3 0.15 11.7 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA10786.1 - 0.063 13.3 0.8 0.063 13.3 0.6 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA10786.1 - 0.11 12.3 0.5 0.11 12.3 0.3 2.5 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.1 ESA10786.1 - 5.8 6.7 10.3 0.26 11.0 0.2 3.0 3 0 0 3 3 3 0 zinc-RING finger domain DSPc PF00782.15 ESA10787.1 - 3.5e-34 117.2 0.0 5.3e-34 116.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA10787.1 - 0.00022 20.6 0.0 0.00031 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DNA_ligase_A_M PF01068.16 ESA10787.1 - 0.029 13.7 0.0 0.062 12.6 0.0 1.6 1 0 0 1 1 1 0 ATP dependent DNA ligase domain DUF793 PF05633.6 ESA10788.1 - 0.19 10.4 1.1 0.25 10.0 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF793) Imm3 PF14425.1 ESA10789.1 - 0.033 14.1 0.7 0.05 13.5 0.4 1.3 1 1 0 1 1 1 0 Immunity protein Imm3 Sec8_exocyst PF04048.9 ESA10789.1 - 0.068 12.7 0.2 0.084 12.4 0.1 1.2 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF2247 PF10004.4 ESA10789.1 - 0.075 12.7 0.4 0.093 12.4 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) RNase_P_pop3 PF08228.6 ESA10789.1 - 0.11 12.2 0.4 0.13 12.0 0.2 1.2 1 0 0 1 1 1 0 RNase P subunit Pop3 ATP-synt_E_2 PF08112.6 ESA10789.1 - 0.15 12.1 3.1 0.26 11.3 2.2 1.5 1 0 0 1 1 1 0 ATP synthase epsilon subunit NYD-SP28 PF14772.1 ESA10789.1 - 0.73 9.9 3.4 2 8.5 2.4 1.6 1 1 0 1 1 1 0 Sperm tail PRKCSH_1 PF13015.1 ESA10793.1 - 0.088 12.2 1.0 0.16 11.4 0.7 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein FCP1_C PF09309.5 ESA10793.1 - 0.76 9.0 9.2 1.2 8.4 6.4 1.3 1 0 0 1 1 1 0 FCP1, C-terminal E1_DerP2_DerF2 PF02221.10 ESA10795.1 - 2.2e-09 37.6 1.1 2.6e-09 37.4 0.7 1.1 1 0 0 1 1 1 1 ML domain TetR_C_8 PF14278.1 ESA10796.1 - 0.033 14.5 0.1 0.088 13.1 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region Pkinase PF00069.20 ESA10797.1 - 5.2e-39 133.9 0.4 6.3e-39 133.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10797.1 - 7.5e-32 110.4 0.0 9.3e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA10797.1 - 0.00025 20.4 0.1 0.0009 18.6 0.0 1.9 3 0 0 3 3 3 1 RIO1 family APH PF01636.18 ESA10797.1 - 0.0048 16.6 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA10797.1 - 0.018 14.3 0.1 0.027 13.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA10797.1 - 0.024 13.6 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA10797.1 - 0.047 12.6 0.0 0.076 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RNA_pol_Rpb2_6 PF00562.23 ESA10799.1 - 6.5e-88 295.0 0.0 8.8e-88 294.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.15 ESA10799.1 - 2.3e-21 75.8 0.2 7.9e-21 74.1 0.1 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF2717 PF10911.3 ESA10801.1 - 0.035 13.5 0.7 0.068 12.6 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2717) Yippee-Mis18 PF03226.9 ESA10803.1 - 0.071 13.1 1.2 0.08 12.9 0.9 1.2 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2H2_jaz PF12171.3 ESA10803.1 - 0.14 12.3 3.9 1.7 8.9 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA10803.1 - 0.44 10.8 5.1 2 8.7 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type BTB PF00651.26 ESA10804.1 - 3.2e-18 65.7 0.4 6.5e-18 64.7 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA10804.1 - 1.5e-08 34.4 9.4 3.1e-07 30.1 0.4 4.2 4 1 1 5 5 5 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA10804.1 - 0.039 14.0 0.1 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Herpes_Helicase PF02689.9 ESA10805.1 - 6.9e-06 24.1 0.0 6.9e-06 24.1 0.0 1.0 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 ESA10805.1 - 0.011 15.2 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 ESA10805.1 - 0.021 14.9 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain PIF1 PF05970.9 ESA10806.1 - 4.9e-13 48.7 0.0 5.3e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase PIF1 PF05970.9 ESA10807.1 - 3.9e-44 151.0 0.6 1.7e-33 116.0 0.0 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_19 PF13245.1 ESA10807.1 - 0.024 14.3 0.0 0.042 13.5 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_30 PF13604.1 ESA10807.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.9 ESA10809.1 - 6.7e-19 68.0 0.0 9e-19 67.6 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.1 ESA10809.1 - 4.4e-05 23.1 0.1 7.7e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA10809.1 - 0.00017 21.2 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA10809.1 - 0.00078 18.4 0.0 0.00098 18.0 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.1 ESA10809.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain PhoH PF02562.11 ESA10809.1 - 0.013 14.6 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein TrwB_AAD_bind PF10412.4 ESA10809.1 - 0.038 12.6 0.0 0.061 11.9 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.1 ESA10809.1 - 0.042 13.9 0.0 0.096 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA10809.1 - 0.11 12.3 0.4 3.6 7.4 0.1 2.1 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.4 ESA10809.1 - 0.12 11.3 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 ESA10809.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Kinesin PF00225.18 ESA10809.1 - 0.18 10.4 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 Kinesin motor domain Herpes_Helicase PF02689.9 ESA10810.1 - 1.2e-06 26.6 0.0 1.3e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.13 ESA10810.1 - 0.021 14.3 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 ESA10810.1 - 0.027 14.6 0.0 0.037 14.1 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF3481 PF11980.3 ESA10811.1 - 0.062 13.1 0.1 0.099 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3481) Sel1 PF08238.7 ESA10813.1 - 1.7e-134 435.3 76.1 5.4e-13 49.1 0.1 16.1 16 0 0 16 16 16 16 Sel1 repeat TPR_6 PF13174.1 ESA10813.1 - 5.7e-05 23.3 30.1 3.2 8.4 0.0 10.2 11 1 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10813.1 - 0.00012 22.6 10.9 0.73 10.5 0.0 7.3 6 2 3 9 9 9 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA10813.1 - 0.07 13.1 1.6 6.9 6.7 0.0 4.2 5 1 0 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain Patched PF02460.13 ESA10813.1 - 0.1 10.4 0.6 0.2 9.4 0.4 1.4 1 0 0 1 1 1 0 Patched family TPR_17 PF13431.1 ESA10813.1 - 1.2 9.5 32.4 7.3 7.0 0.0 11.5 11 1 1 12 12 12 0 Tetratricopeptide repeat Inositol_P PF00459.20 ESA10814.1 - 1.7e-65 221.0 0.0 1.8e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Vip3A_N PF12495.3 ESA10815.1 - 0.031 13.9 0.2 0.031 13.9 0.2 1.1 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Imm24 PF15570.1 ESA10815.1 - 0.044 13.5 0.8 0.051 13.3 0.6 1.2 1 0 0 1 1 1 0 Immunity protein 24 GatB_Yqey PF02637.13 ESA10815.1 - 0.045 13.4 1.4 0.047 13.4 1.0 1.0 1 0 0 1 1 1 0 GatB domain Kinetochor_Ybp2 PF08568.5 ESA10816.1 - 2.7e-26 91.9 14.4 7.3e-25 87.2 10.0 2.1 1 1 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin tRNA-synt_1 PF00133.17 ESA10817.1 - 2.4e-180 600.4 0.0 1.4e-179 597.9 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESA10817.1 - 8.9e-22 77.4 0.0 2.2e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESA10817.1 - 8e-18 64.2 0.4 1.6e-07 30.3 0.0 4.7 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 ESA10817.1 - 1.5e-10 40.6 0.1 7.7e-09 35.1 0.0 2.3 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.14 ESA10817.1 - 5.7e-06 25.6 0.0 0.13 11.3 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 ESA10817.1 - 4.7e-05 22.3 0.0 0.0017 17.2 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (R) tRNA-synt_1b PF00579.20 ESA10817.1 - 0.04 13.0 0.0 0.39 9.8 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) RPA_C PF08784.6 ESA10817.1 - 0.16 12.3 0.1 24 5.4 0.0 2.8 2 0 0 2 2 2 0 Replication protein A C terminal Band_7 PF01145.20 ESA10818.1 - 1.2e-22 80.6 1.3 1.5e-22 80.3 0.9 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 ESA10818.1 - 0.055 12.9 0.0 0.083 12.3 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family L_HGMIC_fpl PF10242.4 ESA10819.1 - 2.8e-06 27.4 3.8 6.8e-05 22.9 0.1 2.0 1 1 1 2 2 2 2 Lipoma HMGIC fusion partner-like protein BioY PF02632.9 ESA10819.1 - 0.63 9.6 6.9 0.43 10.2 1.4 2.5 2 1 1 3 3 3 0 BioY family BAR_2 PF10455.4 ESA10820.1 - 4.3e-47 160.4 2.6 8.8e-46 156.1 1.8 2.0 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 ESA10820.1 - 1.4e-26 93.4 1.4 5.8e-26 91.4 1.0 1.8 1 1 0 1 1 1 1 BAR domain TMF_TATA_bd PF12325.3 ESA10820.1 - 0.066 12.9 5.9 1.1 8.9 1.6 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4110 PF13422.1 ESA10820.1 - 0.62 9.9 4.8 1.2 8.9 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4110) Pyridoxal_deC PF00282.14 ESA10821.1 - 6.2e-26 90.7 0.0 8.4e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 ESA10821.1 - 1.3e-11 43.8 0.0 2.8e-11 42.8 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 ESA10821.1 - 1.7e-06 27.3 0.1 2.5e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 ESA10821.1 - 0.015 13.6 0.0 0.023 13.0 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme peroxidase PF00141.18 ESA10823.1 - 1.2e-51 175.3 0.0 1.7e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 Peroxidase CamS PF07537.6 ESA10823.1 - 0.078 11.9 0.1 0.33 9.9 0.2 1.7 2 0 0 2 2 2 0 CamS sex pheromone cAM373 precursor Pro_CA PF00484.14 ESA10824.1 - 9.3e-45 152.3 0.0 1.3e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase Pkinase_Tyr PF07714.12 ESA10827.1 - 2e-34 118.8 0.0 2.2e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10827.1 - 5.5e-32 110.9 0.0 6.1e-32 110.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA10827.1 - 0.0025 17.6 0.1 0.0037 17.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA10827.1 - 0.065 12.2 0.1 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA10827.1 - 0.11 12.0 0.1 0.18 11.3 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Dimer_Tnp_hAT PF05699.9 ESA10828.1 - 5.4e-14 51.5 0.1 5.8e-14 51.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Cor1 PF04803.7 ESA10829.1 - 0.015 15.0 2.5 0.062 13.0 0.1 2.1 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region EcoEI_R_C PF08463.5 ESA10829.1 - 0.06 13.1 1.0 0.25 11.1 0.1 2.0 2 0 0 2 2 2 0 EcoEI R protein C-terminal PH_11 PF15413.1 ESA10829.1 - 0.29 11.3 2.6 0.22 11.7 0.5 1.6 1 1 1 2 2 2 0 Pleckstrin homology domain PGC7_Stella PF15549.1 ESA10829.1 - 0.74 9.7 6.1 0.29 11.0 0.1 2.0 1 1 1 2 2 2 0 PGC7/Stella/Dppa3 domain DUF3347 PF11827.3 ESA10829.1 - 1.6 8.7 9.6 7.2 6.5 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3347) zf-C2H2 PF00096.21 ESA10834.1 - 2.6e-20 71.4 19.4 3.6e-08 33.2 1.8 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA10834.1 - 3.2e-20 71.3 16.1 4.9e-10 39.1 0.6 3.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA10834.1 - 2e-16 59.0 20.2 3.5e-07 30.0 1.6 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA10834.1 - 1.6e-06 28.0 4.6 0.041 14.0 0.0 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA10834.1 - 4.5e-06 26.6 6.7 0.086 13.0 0.2 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA10834.1 - 3.4e-05 23.5 4.5 0.17 11.8 0.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-TRAF PF02176.13 ESA10834.1 - 0.00046 20.5 10.4 0.00047 20.4 2.0 2.2 1 1 0 2 2 2 1 TRAF-type zinc finger zf-C2H2_2 PF12756.2 ESA10834.1 - 0.0068 16.5 6.8 1.6 8.9 0.1 3.0 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.1 ESA10834.1 - 0.022 14.9 16.2 0.023 14.9 0.5 3.5 3 1 0 3 3 3 0 C2H2-type zinc-finger domain Prok-RING_1 PF14446.1 ESA10834.1 - 0.058 13.1 2.3 3.6 7.3 0.1 2.8 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-Di19 PF05605.7 ESA10834.1 - 0.07 13.2 12.5 0.1 12.7 2.7 2.2 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2225 PF09986.4 ESA10834.1 - 0.11 11.9 5.2 0.7 9.3 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-MIZ PF02891.15 ESA10834.1 - 0.15 11.6 8.0 3.7 7.1 0.1 2.7 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger zf-BED PF02892.10 ESA10834.1 - 0.17 11.7 10.8 2.1 8.1 0.3 3.2 2 1 1 3 3 3 0 BED zinc finger zf-RING_2 PF13639.1 ESA10834.1 - 0.24 11.2 10.5 1.2 9.0 0.6 2.5 2 1 0 2 2 2 0 Ring finger domain C1_4 PF07975.7 ESA10834.1 - 0.52 10.3 5.6 57 3.8 3.6 2.4 1 1 0 1 1 1 0 TFIIH C1-like domain zf-AN1 PF01428.11 ESA10834.1 - 0.7 9.8 9.5 0.75 9.7 0.7 2.7 1 1 1 2 2 2 0 AN1-like Zinc finger zf-met2 PF12907.2 ESA10834.1 - 0.76 9.7 0.1 0.76 9.7 0.1 3.1 2 1 1 3 3 3 0 Zinc-binding Rad50_zn_hook PF04423.9 ESA10834.1 - 2.9 7.4 7.5 2.8 7.4 0.2 2.4 1 1 1 2 2 2 0 Rad50 zinc hook motif zf-C3HC4 PF00097.20 ESA10834.1 - 3.3 7.4 9.4 4 7.1 2.9 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C2HC_2 PF13913.1 ESA10834.1 - 3.3 7.4 17.2 1.3 8.8 1.5 3.5 3 1 0 3 3 3 0 zinc-finger of a C2HC-type IBR PF01485.16 ESA10834.1 - 3.8 7.4 8.8 5.8 6.8 2.0 2.4 1 1 1 2 2 2 0 IBR domain GAGA PF09237.6 ESA10834.1 - 5.1 6.7 12.9 2.5 7.7 2.2 2.4 1 1 1 2 2 2 0 GAGA factor zf-RING_5 PF14634.1 ESA10834.1 - 5.2 6.8 10.5 4.2 7.1 0.5 2.5 2 1 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA10834.1 - 5.6 6.7 10.5 3.7 7.2 0.3 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4379 PF14311.1 ESA10834.1 - 7.4 6.4 8.1 9.2 6.1 0.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4379) Pkinase_Tyr PF07714.12 ESA10835.1 - 2.1e-41 141.7 0.0 6.2e-39 133.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA10835.1 - 4.9e-35 120.9 0.4 1.8e-31 109.2 0.0 2.3 2 1 0 2 2 2 2 Protein kinase domain Kdo PF06293.9 ESA10835.1 - 0.0078 15.2 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA10836.1 - 7.6e-40 136.6 3.5 7.7e-40 136.6 1.7 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10836.1 - 1.6e-37 128.9 0.2 2.2e-37 128.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA10836.1 - 4.2e-06 26.2 0.2 9.1e-06 25.1 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA10836.1 - 0.00017 20.6 0.2 0.00043 19.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like PIP49_C PF12260.3 ESA10836.1 - 0.0019 17.6 0.3 0.0043 16.4 0.2 1.7 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 WaaY PF06176.6 ESA10836.1 - 0.007 15.5 6.2 0.011 14.9 4.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA10836.1 - 0.0086 15.8 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA10836.1 - 0.033 13.2 0.2 0.052 12.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA10837.1 - 0.019 14.0 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.20 ESA10837.1 - 0.037 13.1 0.6 0.068 12.3 0.1 1.7 2 1 0 2 2 2 0 Protein kinase domain OprF PF05736.6 ESA10838.1 - 0.027 13.9 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 OprF membrane domain ELK PF03789.8 ESA10840.1 - 0.43 10.4 0.1 0.43 10.4 0.1 2.7 4 0 0 4 4 4 0 ELK domain zf-RING_4 PF14570.1 ESA10841.1 - 1.5e-21 75.6 15.5 3.1e-21 74.6 10.7 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.17 ESA10841.1 - 4.5e-06 26.1 0.0 0.056 13.0 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA10841.1 - 1.3e-05 24.9 0.0 7.7e-05 22.4 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.1 ESA10841.1 - 0.00076 19.2 16.2 0.00076 19.2 11.2 1.6 2 0 0 2 2 2 1 Ring finger domain XkdN PF08890.6 ESA10841.1 - 0.0041 16.8 0.3 0.0062 16.2 0.2 1.2 1 0 0 1 1 1 1 Phage XkdN-like protein zf-C3HC4_2 PF13923.1 ESA10841.1 - 0.0042 17.0 14.6 0.011 15.7 10.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Nup35_RRM_2 PF14605.1 ESA10841.1 - 0.018 14.8 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESA10841.1 - 0.029 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-C3HC4 PF00097.20 ESA10841.1 - 0.16 11.6 14.4 0.57 9.8 10.0 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1154 PF06631.6 ESA10841.1 - 0.33 10.6 6.2 0.52 10.0 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) Rtf2 PF04641.7 ESA10841.1 - 0.35 10.0 7.0 0.51 9.4 4.9 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger zf-UDP PF14569.1 ESA10841.1 - 0.64 9.8 9.7 2.1 8.1 6.7 1.9 1 1 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.6 ESA10841.1 - 2 8.1 17.0 0.029 14.1 5.7 2.2 2 1 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) MIR PF02815.14 ESA10842.1 - 0.00039 20.0 0.6 0.019 14.5 0.0 2.3 2 0 0 2 2 2 2 MIR domain DUF4430 PF14478.1 ESA10842.1 - 0.039 13.9 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4430) DUF2532 PF10811.3 ESA10843.1 - 0.27 11.0 9.0 2.3 8.0 5.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2532) Barstar PF01337.13 ESA10844.1 - 0.028 14.2 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 Barstar (barnase inhibitor) Myb_DNA-bind_6 PF13921.1 ESA10845.1 - 4.6e-12 45.8 11.3 7.7e-08 32.3 0.5 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA10845.1 - 1.5e-07 31.3 3.3 0.0083 16.1 0.6 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA10845.1 - 0.0089 15.9 8.5 0.21 11.5 3.7 2.3 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA10845.1 - 0.097 12.8 12.9 0.38 10.9 0.2 2.8 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like NHase_beta PF02211.10 ESA10845.1 - 0.17 11.5 1.8 0.22 11.1 1.3 1.2 1 0 0 1 1 1 0 Nitrile hydratase beta subunit FAM74 PF15026.1 ESA10845.1 - 0.19 11.3 3.8 0.55 9.8 2.1 1.8 2 0 0 2 2 2 0 FAM74 protein FB_lectin PF07367.6 ESA10845.1 - 1.2 8.7 5.6 1.3 8.5 3.2 1.7 1 1 0 1 1 1 0 Fungal fruit body lectin DUF3482 PF11981.3 ESA10846.1 - 0.03 13.5 1.0 0.062 12.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Atg14 PF10186.4 ESA10846.1 - 0.28 10.0 8.5 0.57 9.0 4.8 2.1 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CASP_C PF08172.7 ESA10847.1 - 0.012 14.6 1.8 0.017 14.1 1.3 1.2 1 0 0 1 1 1 0 CASP C terminal DUF1479 PF07350.7 ESA10847.1 - 0.023 13.1 2.6 0.035 12.5 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) GAS PF13851.1 ESA10847.1 - 0.5 9.5 15.0 0.68 9.0 7.7 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.7 ESA10847.1 - 1.3 9.4 3.9 2.6 8.4 2.0 1.9 2 0 0 2 2 2 0 SlyX DUF2570 PF10828.3 ESA10847.1 - 5.1 6.7 10.4 1.9 8.1 5.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2570) DUF4623 PF15416.1 ESA10848.1 - 0.0045 15.4 0.0 0.0055 15.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4623) RE_Alw26IDE PF09665.5 ESA10848.1 - 0.012 14.4 1.5 0.022 13.5 0.9 1.5 1 1 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Matrilin_ccoil PF10393.4 ESA10850.1 - 0.11 11.9 45.1 0.16 11.3 2.7 6.4 6 1 0 6 6 6 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF458 PF04308.7 ESA10850.1 - 0.71 9.5 10.6 0.11 12.2 3.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF458) TMEM154 PF15102.1 ESA10851.1 - 0.00079 19.1 2.7 0.00079 19.1 1.9 2.5 3 0 0 3 3 3 1 TMEM154 protein family DUF4064 PF13273.1 ESA10851.1 - 0.048 13.7 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Hum_adeno_E3A PF05393.6 ESA10851.1 - 0.056 13.1 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein OSTbeta PF15048.1 ESA10851.1 - 0.061 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein Herpes_gE PF02480.11 ESA10851.1 - 0.08 11.1 0.0 0.16 10.2 0.0 1.5 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E V_ATPase_I PF01496.14 ESA10851.1 - 0.089 10.6 0.2 2.3 5.9 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family YchF-GTPase_C PF06071.8 ESA10852.1 - 1.2e-36 124.2 0.2 2.7e-36 123.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 ESA10852.1 - 1.6e-20 73.1 0.0 1.3e-19 70.2 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA10852.1 - 6.6e-08 31.9 0.0 1.6e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESA10852.1 - 0.00053 19.8 0.1 1.2 8.9 0.0 2.8 1 1 2 3 3 3 2 Dynamin family AAA_17 PF13207.1 ESA10852.1 - 0.0014 19.4 0.1 0.0059 17.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 ESA10852.1 - 0.011 15.3 0.0 0.49 10.1 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 ESA10852.1 - 0.015 14.1 0.1 0.052 12.3 0.0 1.8 2 0 0 2 2 2 0 ArgK protein AAA_14 PF13173.1 ESA10852.1 - 0.067 13.0 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 ESA10852.1 - 0.093 12.1 0.0 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.13 ESA10852.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF972 PF06156.8 ESA10853.1 - 9.3 6.6 8.0 3.1 8.1 3.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF972) MCPsignal PF00015.16 ESA10855.1 - 0.0015 18.1 0.2 0.002 17.7 0.1 1.1 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain SseC PF04888.7 ESA10855.1 - 0.0018 17.6 0.8 0.0022 17.3 0.5 1.2 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family Lipoprotein_7 PF01540.11 ESA10855.1 - 0.0023 17.0 3.2 0.0028 16.7 2.2 1.3 1 0 0 1 1 1 1 Adhesin lipoprotein DUF904 PF06005.7 ESA10855.1 - 0.0072 16.5 11.2 0.36 11.1 2.9 3.5 1 1 0 2 2 2 1 Protein of unknown function (DUF904) DUF1640 PF07798.6 ESA10855.1 - 0.0094 16.0 7.2 0.2 11.6 1.8 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1640) DUF1917 PF08939.5 ESA10855.1 - 0.0097 15.6 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Bul1_C PF04426.7 ESA10855.1 - 0.013 14.7 5.6 0.18 10.9 3.8 1.9 1 1 0 1 1 1 0 Bul1 C terminus Gp58 PF07902.6 ESA10855.1 - 0.013 13.7 0.5 0.014 13.6 0.3 1.1 1 0 0 1 1 1 0 gp58-like protein Syntaxin-6_N PF09177.6 ESA10855.1 - 0.018 15.4 3.2 0.14 12.5 0.5 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Rootletin PF15035.1 ESA10855.1 - 0.02 14.8 5.2 0.028 14.4 1.7 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion LOH1CR12 PF10158.4 ESA10855.1 - 0.032 14.0 1.6 0.045 13.5 1.1 1.2 1 0 0 1 1 1 0 Tumour suppressor protein EAP30 PF04157.11 ESA10855.1 - 0.037 13.1 0.4 0.047 12.8 0.3 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family EzrA PF06160.7 ESA10855.1 - 0.038 12.1 7.7 0.046 11.9 5.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF1515 PF07439.6 ESA10855.1 - 0.041 13.7 1.8 0.06 13.1 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) Mnd1 PF03962.10 ESA10855.1 - 0.047 13.3 7.1 0.047 13.3 2.5 2.0 1 1 1 2 2 2 0 Mnd1 family DUF2968 PF11180.3 ESA10855.1 - 0.049 13.0 0.3 0.066 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Laminin_II PF06009.7 ESA10855.1 - 0.054 13.2 6.8 0.039 13.7 2.4 2.1 2 1 0 2 2 2 0 Laminin Domain II Atg14 PF10186.4 ESA10855.1 - 0.079 11.8 5.5 0.11 11.3 3.8 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 ESA10855.1 - 0.093 11.3 9.6 0.075 11.6 5.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein ALMT PF11744.3 ESA10855.1 - 0.11 11.1 2.8 0.11 11.1 2.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Thioredoxin PF00085.15 ESA10855.1 - 0.11 12.2 0.4 0.26 10.9 0.3 1.7 1 1 1 2 2 2 0 Thioredoxin DUF948 PF06103.6 ESA10855.1 - 0.11 12.3 2.7 0.51 10.2 1.6 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) GAS PF13851.1 ESA10855.1 - 0.12 11.5 10.3 0.18 10.9 7.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 ESA10855.1 - 0.12 11.5 0.4 0.13 11.3 0.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HlyD_2 PF12700.2 ESA10855.1 - 0.13 11.4 3.8 0.14 11.3 2.6 1.1 1 0 0 1 1 1 0 HlyD family secretion protein APG6 PF04111.7 ESA10855.1 - 0.14 11.1 5.8 0.17 10.9 4.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF489 PF04356.7 ESA10855.1 - 0.16 11.5 2.5 0.18 11.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) WXG100 PF06013.7 ESA10855.1 - 0.16 11.9 0.5 2.2 8.3 0.1 2.4 1 1 0 2 2 2 0 Proteins of 100 residues with WXG DUF1664 PF07889.7 ESA10855.1 - 0.18 11.5 7.9 0.12 12.1 4.1 1.8 2 1 0 2 2 1 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.8 ESA10855.1 - 0.19 12.4 3.5 0.33 11.6 2.1 1.7 1 1 0 1 1 1 0 Occludin homology domain Poty_PP PF08440.5 ESA10855.1 - 0.21 10.6 5.5 0.81 8.6 0.9 2.0 1 1 1 2 2 2 0 Potyviridae polyprotein His_kinase PF06580.8 ESA10855.1 - 0.23 11.4 1.8 0.87 9.5 0.2 2.2 1 1 1 2 2 2 0 Histidine kinase COG5 PF10392.4 ESA10855.1 - 0.25 11.2 5.0 0.39 10.6 2.4 2.0 1 1 1 2 2 2 0 Golgi transport complex subunit 5 WEMBL PF05701.6 ESA10855.1 - 0.3 9.5 7.0 0.42 9.0 4.8 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light NEP PF10167.4 ESA10855.1 - 0.31 10.7 3.2 1 9.0 1.7 2.1 1 1 1 2 2 2 0 Uncharacterised conserved protein AATF-Che1 PF13339.1 ESA10855.1 - 0.35 11.0 4.6 0.23 11.6 1.6 1.7 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Baculo_PEP_C PF04513.7 ESA10855.1 - 0.35 10.6 3.2 0.25 11.1 0.9 1.8 2 1 0 2 2 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIVA PF05103.8 ESA10855.1 - 0.35 10.9 4.8 0.87 9.6 0.2 2.3 1 1 1 2 2 2 0 DivIVA protein Fib_alpha PF08702.5 ESA10855.1 - 0.37 10.8 8.7 0.87 9.7 5.9 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF972 PF06156.8 ESA10855.1 - 0.49 10.7 5.3 0.25 11.6 0.5 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF1319 PF07028.6 ESA10855.1 - 0.62 10.2 7.5 0.5 10.5 1.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) IncA PF04156.9 ESA10855.1 - 0.68 9.5 9.9 0.58 9.7 5.0 1.9 1 1 0 1 1 1 0 IncA protein DUF3573 PF12097.3 ESA10855.1 - 0.68 8.4 4.9 2.5 6.6 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) NPV_P10 PF05531.7 ESA10855.1 - 0.7 10.1 4.3 2.1 8.6 1.4 2.6 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.1 ESA10855.1 - 1.1 9.6 6.6 2.4 8.5 3.2 2.4 1 1 2 3 3 3 0 Snapin/Pallidin FlaC_arch PF05377.6 ESA10855.1 - 1.1 9.1 11.5 6.4 6.7 0.1 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Tup_N PF08581.5 ESA10855.1 - 1.3 9.2 9.3 2.7 8.2 0.2 3.1 2 1 0 3 3 3 0 Tup N-terminal Spectrin PF00435.16 ESA10855.1 - 1.4 9.2 5.0 0.61 10.4 1.3 1.9 2 1 0 2 2 1 0 Spectrin repeat DUF1451 PF07295.6 ESA10855.1 - 1.4 8.6 5.7 5.8 6.6 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1451) LRR_4 PF12799.2 ESA10855.1 - 1.5 8.5 4.1 17 5.1 0.1 3.3 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) TPR_MLP1_2 PF07926.7 ESA10855.1 - 1.9 8.2 8.7 8 6.2 6.0 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Med28 PF11594.3 ESA10855.1 - 1.9 8.7 8.6 7.4 6.8 3.9 2.5 1 1 2 3 3 3 0 Mediator complex subunit 28 RPW8 PF05659.6 ESA10855.1 - 3 7.3 7.9 3.1 7.3 3.5 1.9 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ACCA PF03255.9 ESA10855.1 - 3.2 7.3 5.4 6.5 6.2 1.0 2.5 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Syntaxin PF00804.20 ESA10855.1 - 9.3 6.4 9.2 50 4.1 6.3 2.2 1 1 0 1 1 1 0 Syntaxin zf-H2C2_2 PF13465.1 ESA10858.1 - 1.9e-70 229.9 102.4 3.3e-08 33.4 1.6 15.1 15 0 0 15 15 15 14 Zinc-finger double domain zf-C2H2 PF00096.21 ESA10858.1 - 2.2e-60 197.4 95.1 4e-05 23.7 0.3 14.2 14 0 0 14 14 14 14 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA10858.1 - 2.7e-41 136.8 80.0 0.00056 20.0 0.6 14.2 14 0 0 14 14 14 14 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA10858.1 - 2.9e-12 46.0 49.3 0.11 12.4 0.0 11.9 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA10858.1 - 3.4e-08 33.4 67.7 0.069 13.3 0.1 14.0 14 0 0 14 14 14 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA10858.1 - 0.12 12.6 61.7 0.37 11.0 0.2 12.1 13 0 0 13 13 13 0 Zinc-finger of C2H2 type Aldo_ket_red PF00248.16 ESA10859.1 - 6.3e-27 94.1 0.0 7.6e-27 93.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1227 PF06777.6 ESA10860.1 - 3.4e-59 198.7 0.2 6.2e-59 197.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 ESA10860.1 - 5.9e-50 169.0 0.4 9.4e-50 168.4 0.3 1.3 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 ESA10860.1 - 8.6e-46 155.9 0.0 2e-45 154.7 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain SNF2_N PF00176.18 ESA10860.1 - 7.6e-06 24.9 0.0 1.7e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ESA10860.1 - 0.0029 17.1 0.1 0.83 9.1 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 ESA10860.1 - 0.0097 15.7 0.0 0.24 11.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.1 ESA10860.1 - 0.011 15.3 0.0 0.021 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 ESA10860.1 - 0.026 13.7 0.1 0.38 9.9 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.1 ESA10860.1 - 0.14 12.3 0.1 10 6.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF972 PF06156.8 ESA10861.1 - 0.028 14.7 6.1 0.041 14.2 3.8 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Pkinase PF00069.20 ESA10862.1 - 5.5e-45 153.5 0.1 7.2e-45 153.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10862.1 - 1.2e-44 152.3 0.0 1.5e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA10862.1 - 9e-06 24.8 0.0 0.00098 18.1 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ESA10862.1 - 0.0003 20.6 0.1 0.016 14.9 0.2 2.8 1 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA10862.1 - 0.0042 16.4 0.3 0.0095 15.3 0.2 1.6 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA10862.1 - 0.0074 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA10862.1 - 0.012 14.8 0.1 0.018 14.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) PBS_linker_poly PF00427.16 ESA10862.1 - 0.023 14.3 0.1 0.53 9.9 0.0 2.2 2 0 0 2 2 2 0 Phycobilisome Linker polypeptide YrbL-PhoP_reg PF10707.4 ESA10862.1 - 0.027 13.8 0.1 0.058 12.7 0.1 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase PF00069.20 ESA10865.1 - 5.4e-10 38.8 0.3 7.7e-10 38.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA10865.1 - 3e-06 26.4 0.1 5.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA10865.1 - 4.7e-06 25.8 0.0 6.5e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 ESA10865.1 - 0.0061 16.1 0.5 0.0074 15.8 0.3 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 ESA10865.1 - 0.066 12.5 0.1 0.099 11.9 0.1 1.2 1 0 0 1 1 1 0 RIO1 family HAMP PF00672.20 ESA10865.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 HAMP domain Pkinase PF00069.20 ESA10867.1 - 7.2e-31 107.2 0.2 9.2e-31 106.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10867.1 - 2.4e-28 98.9 0.1 3e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA10867.1 - 0.0076 15.3 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_C97 PF05903.9 ESA10870.1 - 0.014 15.1 0.3 0.12 12.1 0.2 2.2 1 1 0 1 1 1 0 PPPDE putative peptidase domain DUF1749 PF08538.5 ESA10870.1 - 0.048 12.5 0.0 0.078 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF1510 PF07423.6 ESA10872.1 - 0.00098 18.5 0.1 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) Mucin PF01456.12 ESA10872.1 - 0.0055 16.4 0.0 0.0095 15.7 0.0 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein TRAP_alpha PF03896.11 ESA10872.1 - 0.0058 15.6 1.9 0.0082 15.1 1.3 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit TMEM154 PF15102.1 ESA10872.1 - 0.0091 15.7 0.3 0.018 14.7 0.0 1.7 1 1 1 2 2 2 1 TMEM154 protein family DUF1443 PF07280.6 ESA10872.1 - 0.016 14.7 0.1 0.016 14.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) FAM176 PF14851.1 ESA10872.1 - 0.02 14.5 3.4 0.037 13.7 2.3 1.5 1 1 0 1 1 1 0 FAM176 family SIT PF15330.1 ESA10872.1 - 0.033 14.3 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF843 PF05814.6 ESA10872.1 - 0.074 12.8 0.6 2.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) Tweety PF04906.8 ESA10872.1 - 0.075 11.4 1.2 0.13 10.6 0.8 1.3 1 0 0 1 1 1 0 Tweety DUF975 PF06161.6 ESA10872.1 - 0.081 12.6 1.8 0.093 12.4 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF975) Herpes_gE PF02480.11 ESA10872.1 - 0.11 10.7 1.8 0.19 9.9 1.2 1.4 1 1 0 1 1 1 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.1 ESA10872.1 - 0.14 12.6 1.3 0.16 12.3 0.1 1.9 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain LST1 PF05083.8 ESA10872.1 - 0.15 12.0 0.2 0.15 12.0 0.1 1.9 2 1 0 2 2 2 0 LST-1 protein VirB3 PF05101.8 ESA10872.1 - 0.16 11.9 0.1 2 8.4 0.0 2.0 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein EpsG PF14897.1 ESA10872.1 - 0.27 10.1 4.1 0.39 9.5 2.3 1.6 1 1 0 1 1 1 0 EpsG family DAP10 PF07213.6 ESA10872.1 - 0.41 10.4 2.6 0.68 9.7 0.2 2.0 1 1 1 2 2 2 0 DAP10 membrane protein ABC2_membrane_3 PF12698.2 ESA10872.1 - 0.57 9.1 4.8 0.83 8.6 3.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein RCR PF12273.3 ESA10872.1 - 2.3 8.8 7.8 0.29 11.7 1.1 2.2 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red zf-H2C2_2 PF13465.1 ESA10873.1 - 0.098 12.9 9.8 2.1 8.8 1.5 2.6 2 0 0 2 2 2 0 Zinc-finger double domain Pkinase PF00069.20 ESA10874.1 - 1.3e-06 27.7 0.0 1.6e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10874.1 - 1.8e-06 27.2 0.0 2.3e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Alpha_kinase PF02816.13 ESA10876.1 - 4.7e-37 127.4 0.8 4.7e-37 127.4 0.5 2.0 2 0 0 2 2 2 1 Alpha-kinase family VWA_2 PF13519.1 ESA10876.1 - 8e-06 26.0 0.0 2.1e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 ESA10876.1 - 0.0052 16.5 0.2 0.014 15.1 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF3662 PF12401.3 ESA10877.1 - 0.075 13.2 0.1 0.082 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) DUF3226 PF11536.3 ESA10878.1 - 0.054 12.9 0.2 0.054 12.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3226) FTH PF01827.22 ESA10879.1 - 0.069 12.7 0.3 0.62 9.6 0.2 2.4 1 1 0 1 1 1 0 FTH domain CHCH PF06747.8 ESA10879.1 - 0.1 12.5 0.2 0.37 10.7 0.1 2.0 1 0 0 1 1 1 0 CHCH domain Pkinase_Tyr PF07714.12 ESA10880.1 - 1.4e-36 125.8 0.0 6.9e-36 123.6 0.0 1.9 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10880.1 - 1.7e-32 112.5 0.2 3.5e-32 111.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA10880.1 - 0.0044 16.1 0.1 0.0089 15.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA10880.1 - 0.059 13.1 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribonuc_red_sm PF00268.16 ESA10881.1 - 5.5e-119 396.3 0.8 6.4e-119 396.1 0.6 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF2283 PF10049.4 ESA10884.1 - 8.3e-09 35.1 0.7 1.7e-08 34.1 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2283) DUF1125 PF06563.6 ESA10884.1 - 0.25 11.0 4.6 3.8 7.2 0.0 3.6 2 2 0 3 3 3 0 Protein of unknown function (DUF1125) Pkinase PF00069.20 ESA10885.1 - 5.3e-73 245.3 0.2 8.5e-73 244.6 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10885.1 - 6.1e-52 176.2 0.2 6.1e-52 176.2 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.23 ESA10885.1 - 1.1e-21 76.9 0.0 3.9e-21 75.2 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.24 ESA10885.1 - 1.8e-11 44.1 2.0 4e-11 43.0 1.4 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 ESA10885.1 - 1.5e-06 27.3 0.0 2.5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 ESA10885.1 - 3.5e-06 27.2 1.4 0.086 13.1 0.1 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain APH PF01636.18 ESA10885.1 - 0.012 15.3 0.1 0.07 12.8 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA10885.1 - 0.025 13.3 0.1 0.046 12.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PH_9 PF15410.1 ESA10885.1 - 0.057 13.5 0.4 0.61 10.2 0.2 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain DUF605 PF04652.11 ESA10885.1 - 0.068 12.5 30.8 0.096 12.0 21.3 1.2 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 ESA10885.1 - 0.39 8.9 28.9 0.51 8.5 20.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S55 PF05580.7 ESA10886.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 SpoIVB peptidase S55 F-box-like PF12937.2 ESA10892.1 - 4.3e-06 26.3 0.4 6.8e-06 25.7 0.3 1.3 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA10893.1 - 0.002 17.7 5.3 0.0033 17.1 0.4 3.1 3 0 0 3 3 3 1 F-box-like LRR_8 PF13855.1 ESA10894.1 - 3.8e-06 26.5 7.2 0.00022 20.9 0.7 4.6 4 2 3 7 7 7 2 Leucine rich repeat LRR_4 PF12799.2 ESA10894.1 - 0.00013 21.4 13.8 0.00087 18.8 0.8 3.9 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) DUF1844 PF08899.6 ESA10894.1 - 0.033 14.0 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) LRR_6 PF13516.1 ESA10894.1 - 4.6 7.6 12.0 33 4.9 0.1 5.6 5 0 0 5 5 5 0 Leucine Rich repeat F-box-like PF12937.2 ESA10895.1 - 1.6e-05 24.4 0.9 6e-05 22.6 0.6 2.0 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.1 ESA10895.1 - 6.3 7.2 12.7 49 4.4 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich repeat F-box-like PF12937.2 ESA10896.1 - 0.00041 20.0 5.0 0.0013 18.3 1.1 2.9 3 0 0 3 3 3 1 F-box-like PMR5N PF14416.1 ESA10900.1 - 0.1 12.6 0.6 0.17 11.9 0.4 1.3 1 0 0 1 1 1 0 PMR5 N terminal Domain Pkinase_Tyr PF07714.12 ESA10901.1 - 2.8e-39 134.7 0.0 4.7e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10901.1 - 2.3e-36 125.2 0.0 5.1e-36 124.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA10901.1 - 0.0014 17.7 0.1 0.003 16.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA10901.1 - 0.014 15.1 0.1 0.022 14.4 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fumerase_C PF05683.7 ESA10901.1 - 0.046 12.8 0.0 0.08 12.0 0.0 1.3 1 0 0 1 1 1 0 Fumarase C-terminus Glyco_transf_22 PF03901.12 ESA10904.1 - 6.5e-83 279.0 29.8 7.6e-83 278.8 20.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.1 ESA10904.1 - 0.011 15.6 15.6 0.011 15.6 10.8 2.4 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Rtf2 PF04641.7 ESA10905.1 - 0.077 12.1 0.2 0.077 12.1 0.1 2.9 2 1 0 2 2 2 0 Rtf2 RING-finger Cryptochrome_C PF12546.3 ESA10905.1 - 7 7.3 9.0 13 6.4 0.8 3.6 2 1 2 4 4 4 0 Blue/Ultraviolet sensing protein C terminal Protocadherin PF08374.6 ESA10906.1 - 0.046 13.3 0.0 0.074 12.6 0.0 1.5 1 1 0 1 1 1 0 Protocadherin DUF4560 PF15118.1 ESA10906.1 - 0.092 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4560) HMG_box PF00505.14 ESA10907.1 - 1.6e-09 37.8 2.8 3.3e-09 36.8 1.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA10907.1 - 0.00016 21.9 2.5 0.00031 21.0 1.7 1.5 1 0 0 1 1 1 1 HMG-box domain tRNA_NucTransf2 PF09249.6 ESA10907.1 - 0.003 17.4 1.2 0.0062 16.4 0.8 1.5 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain Nuf2 PF03800.9 ESA10907.1 - 0.018 14.9 0.3 0.029 14.3 0.2 1.4 1 0 0 1 1 1 0 Nuf2 family S1-P1_nuclease PF02265.11 ESA10907.1 - 0.76 9.3 5.3 2.2 7.8 0.1 2.4 2 1 0 2 2 2 0 S1/P1 Nuclease Pkinase PF00069.20 ESA10908.1 - 5e-11 42.2 0.1 6.9e-11 41.7 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10908.1 - 3.1e-10 39.5 0.0 1.2e-09 37.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase HPHLAWLY PF14925.1 ESA10908.1 - 0.11 10.4 0.1 0.14 10.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function HNH PF01844.18 ESA10909.1 - 0.48 10.3 4.7 6.4 6.7 0.3 2.7 3 0 0 3 3 3 0 HNH endonuclease DUF3941 PF13081.1 ESA10909.1 - 0.58 10.1 3.3 0.6 10.1 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3941) TRP_2 PF08344.6 ESA10909.1 - 0.85 9.6 3.2 13 5.7 0.0 3.0 3 0 0 3 3 3 0 Transient receptor ion channel II DUF1708 PF08101.6 ESA10910.1 - 2.9e-16 59.3 1.3 2.9e-16 59.3 0.9 4.1 2 2 0 2 2 2 1 Domain of unknown function (DUF1708) RhoGAP PF00620.22 ESA10910.1 - 0.017 14.7 2.9 0.023 14.2 0.2 2.7 2 1 1 3 3 3 0 RhoGAP domain Neur_chan_memb PF02932.11 ESA10910.1 - 0.44 10.3 4.4 1.5 8.6 1.2 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3669 PF12417.3 ESA10911.1 - 0.0017 18.0 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 Zinc finger protein BCS1_N PF08740.6 ESA10911.1 - 0.021 14.4 0.0 2.2 7.8 0.0 2.6 3 0 0 3 3 3 0 BCS1 N terminal DUF4339 PF14237.1 ESA10911.1 - 0.042 13.4 0.0 9 5.9 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4339) zf-RING_UBOX PF13445.1 ESA10911.1 - 0.054 13.2 0.4 4 7.2 0.0 3.2 3 0 0 3 3 3 0 RING-type zinc-finger Cyclin PF08613.6 ESA10913.1 - 1.9e-42 145.1 0.8 2.3e-42 144.9 0.5 1.1 1 0 0 1 1 1 1 Cyclin SPC25 PF06703.6 ESA10914.1 - 0.038 13.5 0.7 0.08 12.5 0.5 1.6 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3713 PF12506.3 ESA10915.1 - 0.065 13.3 0.3 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) Hexose_dehydrat PF03559.9 ESA10915.1 - 0.082 11.9 0.1 0.12 11.4 0.1 1.2 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase DUF2972 PF11186.3 ESA10916.1 - 0.063 13.1 1.1 3.5 7.4 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2972) F-box-like PF12937.2 ESA10917.1 - 0.042 13.5 1.9 0.057 13.1 0.1 2.2 2 0 0 2 2 2 0 F-box-like SlyX PF04102.7 ESA10918.1 - 0.00074 19.8 0.7 0.0026 18.1 0.6 1.8 2 0 0 2 2 2 1 SlyX CENP-Q PF13094.1 ESA10918.1 - 0.0016 18.5 0.2 0.003 17.5 0.1 1.4 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.6 ESA10918.1 - 0.017 13.8 5.4 0.026 13.1 3.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TH1 PF04858.8 ESA10918.1 - 0.032 12.3 0.2 0.035 12.2 0.1 1.2 1 0 0 1 1 1 0 TH1 protein Reo_sigmaC PF04582.7 ESA10918.1 - 0.12 11.5 0.1 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Sec2p PF06428.6 ESA10918.1 - 0.23 11.3 2.5 0.2 11.5 0.2 1.9 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p SPATA24 PF15175.1 ESA10918.1 - 1.1 8.9 5.9 0.25 11.0 1.9 1.5 2 0 0 2 2 2 0 Spermatogenesis-associated protein 24 HBS1_N PF08938.5 ESA10919.1 - 0.12 12.5 0.4 0.16 12.1 0.3 1.2 1 0 0 1 1 1 0 HBS1 N-terminus N6-adenineMlase PF10237.4 ESA10920.1 - 1.4e-54 184.1 1.0 2e-54 183.6 0.7 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.10 ESA10920.1 - 0.0066 15.8 0.0 0.017 14.5 0.0 1.7 1 1 0 1 1 1 1 Conserved hypothetical protein 95 EF-hand_4 PF12763.2 ESA10921.1 - 4.3e-30 103.5 0.0 2.1e-28 98.1 0.0 2.5 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.2 ESA10921.1 - 4.3e-22 78.7 17.0 1e-15 57.9 0.0 2.3 1 1 1 2 2 2 2 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.27 ESA10921.1 - 3.1e-05 22.9 0.4 0.00012 21.1 0.2 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 ESA10921.1 - 0.0037 17.3 0.0 0.015 15.3 0.0 2.1 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_6 PF13405.1 ESA10921.1 - 0.0067 16.2 0.2 0.063 13.1 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 ESA10921.1 - 0.0077 15.5 0.3 0.025 13.9 0.2 1.9 1 0 0 1 1 1 1 EF hand Toxin_52 PF15605.1 ESA10921.1 - 0.021 14.7 0.4 0.021 14.7 0.3 2.4 3 0 0 3 3 2 0 Putative toxin 52 EF-hand_8 PF13833.1 ESA10921.1 - 0.037 13.6 0.2 0.1 12.2 0.2 1.7 1 0 0 1 1 1 0 EF-hand domain pair ERM PF00769.14 ESA10921.1 - 0.45 10.0 16.5 0.64 9.5 11.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Cluap1 PF10234.4 ESA10921.1 - 0.53 9.4 13.5 0.82 8.8 9.3 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 Mnd1 PF03962.10 ESA10921.1 - 0.61 9.7 9.2 1.2 8.7 6.4 1.5 1 0 0 1 1 1 0 Mnd1 family DUF2570 PF10828.3 ESA10921.1 - 0.72 9.4 5.2 1.5 8.4 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) COG5 PF10392.4 ESA10921.1 - 0.86 9.5 10.0 0.97 9.4 4.4 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF1811 PF08838.5 ESA10921.1 - 1.9 8.5 6.6 2.5 8.0 1.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1811) Fib_alpha PF08702.5 ESA10921.1 - 2.4 8.2 11.1 4.4 7.4 7.7 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family IncA PF04156.9 ESA10921.1 - 2.6 7.5 21.2 7.4 6.1 14.7 1.5 1 1 0 1 1 1 0 IncA protein PspB PF06667.7 ESA10921.1 - 2.9 7.9 6.9 2.7 8.0 2.3 2.5 2 1 0 2 2 2 0 Phage shock protein B DUF724 PF05266.9 ESA10921.1 - 3 7.4 12.8 0.4 10.2 5.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Laminin_II PF06009.7 ESA10921.1 - 4 7.1 12.5 0.92 9.2 4.9 2.0 1 1 1 2 2 2 0 Laminin Domain II CorA PF01544.13 ESA10921.1 - 4.2 6.3 10.2 6.4 5.7 7.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Exonuc_VII_L PF02601.10 ESA10921.1 - 4.9 6.2 13.5 7.2 5.6 9.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SlyX PF04102.7 ESA10921.1 - 5.7 7.3 9.4 19 5.6 3.2 2.7 2 0 0 2 2 2 0 SlyX HTH_Tnp_Tc5 PF03221.11 ESA10923.1 - 0.0015 18.2 0.3 0.0027 17.4 0.2 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF659 PF04937.10 ESA10924.1 - 0.0038 16.7 0.1 0.0065 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) HTH_Tnp_Tc3_2 PF01498.13 ESA10926.1 - 0.006 16.6 0.0 0.019 15.0 0.0 1.8 2 0 0 2 2 2 1 Transposase HAND PF09110.6 ESA10927.1 - 0.033 14.5 0.3 0.033 14.5 0.2 1.0 1 0 0 1 1 1 0 HAND CsgE PF10627.4 ESA10928.1 - 0.045 13.5 0.4 0.056 13.2 0.2 1.4 1 1 0 1 1 1 0 Curli assembly protein CsgE Lipocalin_6 PF13944.1 ESA10928.1 - 0.3 11.2 3.3 0.49 10.5 2.3 1.4 1 1 0 1 1 1 0 Lipocalin-like domain Pox_A_type_inc PF04508.7 ESA10929.1 - 0.011 15.4 2.6 2.3 8.2 0.4 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF3702 PF12486.3 ESA10929.1 - 0.086 12.5 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 ImpA domain protein TSC22 PF01166.13 ESA10929.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family Pkinase_Tyr PF07714.12 ESA10930.1 - 2e-25 89.3 0.1 2.4e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10930.1 - 1.8e-23 83.0 0.3 2.3e-23 82.6 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF4286 PF14114.1 ESA10930.1 - 0.0041 17.3 1.3 0.064 13.5 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4286) NNMT_PNMT_TEMT PF01234.12 ESA10930.1 - 0.095 11.6 0.9 0.11 11.4 0.0 1.5 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family DUF730 PF05325.6 ESA10931.1 - 0.052 13.3 1.0 0.12 12.1 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF730) IZUMO PF15005.1 ESA10931.1 - 0.28 11.2 6.7 0.49 10.4 0.6 2.9 3 0 0 3 3 3 0 Izumo sperm-egg fusion Pkinase_Tyr PF07714.12 ESA10932.1 - 6.9e-10 38.4 0.3 0.041 12.9 0.0 5.1 5 1 0 5 5 5 3 Protein tyrosine kinase BCS1_N PF08740.6 ESA10932.1 - 6.8e-06 25.8 0.1 1.9 8.0 0.0 5.4 6 0 0 6 6 6 1 BCS1 N terminal Glyco_hydro_11 PF00457.12 ESA10932.1 - 0.00013 21.4 21.1 0.073 12.4 0.3 5.5 3 2 2 5 5 5 2 Glycosyl hydrolases family 11 SpoU_methylas_C PF12105.3 ESA10932.1 - 0.04 13.4 0.0 64 3.2 0.0 3.8 3 0 0 3 3 3 0 SpoU, rRNA methylase, C-terminal DUF4339 PF14237.1 ESA10932.1 - 0.083 12.4 0.0 13 5.4 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4339) Spt5-NGN PF03439.8 ESA10932.1 - 0.2 11.4 1.5 17 5.2 0.0 4.5 6 0 0 6 6 6 0 Early transcription elongation factor of RNA pol II, NGN section DZR PF12773.2 ESA10932.1 - 2.6 7.9 10.6 1.3 8.9 1.9 2.5 2 0 0 2 2 2 0 Double zinc ribbon EAF PF09816.4 ESA10932.1 - 4.2 7.3 10.9 2.1 8.3 0.1 4.4 5 0 0 5 5 5 0 RNA polymerase II transcription elongation factor zinc_ribbon_2 PF13240.1 ESA10932.1 - 4.2 6.9 8.7 33 4.1 0.1 3.1 2 0 0 2 2 2 0 zinc-ribbon domain F-box-like PF12937.2 ESA10936.1 - 5.5e-06 26.0 0.8 5.5e-06 26.0 0.5 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA10936.1 - 0.084 12.5 5.3 0.037 13.7 0.8 2.6 2 0 0 2 2 2 0 F-box domain BK_channel_a PF03493.13 ESA10937.1 - 1.3e-20 73.2 0.1 4e-20 71.6 0.0 2.0 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.11 ESA10937.1 - 2.7e-07 30.2 2.4 3.7e-06 26.5 1.3 2.5 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.13 ESA10937.1 - 0.00056 19.9 0.0 0.094 12.7 0.0 2.4 2 0 0 2 2 2 2 TrkA-N domain Glyco_transf_49 PF13896.1 ESA10938.1 - 1.5e-16 60.3 1.4 2.6e-09 36.6 0.4 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan zf-C2H2 PF00096.21 ESA10939.1 - 8.9e-06 25.7 0.1 2.3e-05 24.4 0.1 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA10939.1 - 3.3e-05 23.9 0.2 0.00039 20.5 0.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA10939.1 - 0.0026 17.8 0.1 0.0067 16.5 0.1 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 ESA10939.1 - 0.0036 17.0 0.1 0.0083 15.8 0.0 1.6 1 0 0 1 1 1 1 BED zinc finger zf-H2C2_2 PF13465.1 ESA10939.1 - 0.013 15.7 0.7 0.084 13.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double domain zf-met PF12874.2 ESA10939.1 - 0.08 13.1 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-Sec23_Sec24 PF04810.10 ESA10939.1 - 0.081 12.4 0.1 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Vps39_2 PF10367.4 ESA10939.1 - 0.12 12.5 2.5 17 5.6 0.0 3.4 1 1 3 4 4 4 0 Vacuolar sorting protein 39 domain 2 rve_2 PF13333.1 ESA10939.1 - 0.68 10.0 3.1 2.7 8.1 0.2 2.7 3 0 0 3 3 3 0 Integrase core domain SlyX PF04102.7 ESA10943.1 - 0.0015 18.8 2.3 0.0048 17.2 1.6 1.8 1 1 0 1 1 1 1 SlyX DUF869 PF05911.6 ESA10943.1 - 0.0071 14.6 7.3 0.0081 14.4 5.1 1.0 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) SPX PF03105.14 ESA10943.1 - 0.0072 16.1 4.1 0.0092 15.7 2.8 1.2 1 0 0 1 1 1 1 SPX domain DUF3373 PF11853.3 ESA10943.1 - 0.0077 14.8 1.6 0.008 14.7 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3373) CENP-Q PF13094.1 ESA10943.1 - 0.013 15.5 3.2 0.016 15.2 2.2 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF724 PF05266.9 ESA10943.1 - 0.018 14.6 4.5 0.019 14.5 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF3568 PF12092.3 ESA10943.1 - 0.018 14.7 0.3 0.029 14.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) DUF972 PF06156.8 ESA10943.1 - 0.027 14.8 5.3 0.047 14.0 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF342 PF03961.8 ESA10943.1 - 0.036 12.4 2.4 0.037 12.4 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Jnk-SapK_ap_N PF09744.4 ESA10943.1 - 0.041 13.8 6.0 0.047 13.6 4.2 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Prefoldin PF02996.12 ESA10943.1 - 0.05 13.2 5.3 0.081 12.5 3.7 1.3 1 0 0 1 1 1 0 Prefoldin subunit Terpene_synth PF01397.16 ESA10943.1 - 0.057 12.7 1.2 0.07 12.4 0.8 1.2 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain CASP_C PF08172.7 ESA10943.1 - 0.068 12.1 4.3 0.078 11.9 3.0 1.3 1 0 0 1 1 1 0 CASP C terminal V_ATPase_I PF01496.14 ESA10943.1 - 0.068 11.0 3.7 0.064 11.1 2.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SWIRM PF04433.12 ESA10943.1 - 0.11 12.6 0.9 0.15 12.2 0.6 1.2 1 0 0 1 1 1 0 SWIRM domain DUF465 PF04325.8 ESA10943.1 - 0.14 11.9 8.8 1.3 8.7 6.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF465) Fmp27_WPPW PF10359.4 ESA10943.1 - 0.14 10.5 4.9 0.15 10.4 3.4 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain APG6 PF04111.7 ESA10943.1 - 0.15 11.0 4.0 0.15 11.0 2.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 ESA10943.1 - 0.18 10.6 4.8 0.2 10.5 3.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4140 PF13600.1 ESA10943.1 - 0.21 12.0 1.5 0.27 11.7 1.1 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF4164 PF13747.1 ESA10943.1 - 0.28 11.3 4.9 0.63 10.2 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) IncA PF04156.9 ESA10943.1 - 0.3 10.6 2.6 0.33 10.5 1.8 1.3 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 ESA10943.1 - 0.48 10.2 11.7 0.14 11.9 6.1 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Lipoprotein_20 PF13942.1 ESA10943.1 - 0.48 9.9 7.0 0.63 9.5 4.8 1.1 1 0 0 1 1 1 0 YfhG lipoprotein DivIC PF04977.10 ESA10943.1 - 0.5 9.8 6.1 0.98 8.9 4.2 1.6 1 1 0 1 1 1 0 Septum formation initiator DUF2681 PF10883.3 ESA10943.1 - 1.9 8.7 6.0 2.3 8.4 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) Macoilin PF09726.4 ESA10943.1 - 2 6.6 8.6 1.3 7.1 5.2 1.2 1 1 0 1 1 1 0 Transmembrane protein MFMR PF07777.6 ESA10943.1 - 6.7 6.5 7.1 11 5.8 4.9 1.5 1 1 0 1 1 1 0 G-box binding protein MFMR zf-C3HC4_2 PF13923.1 ESA10944.1 - 3.6e-10 39.7 9.7 3.6e-10 39.7 6.7 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA10944.1 - 6.5e-09 35.4 9.2 6.5e-09 35.4 6.4 2.7 3 1 0 3 3 3 1 Ring finger domain zf-TRAF PF02176.13 ESA10944.1 - 2.6e-08 34.1 9.2 2.6e-08 34.1 6.4 3.0 2 1 2 4 4 4 2 TRAF-type zinc finger zf-C3HC4_3 PF13920.1 ESA10944.1 - 1.4e-07 31.0 8.6 1.4e-07 31.0 6.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 ESA10944.1 - 2.3e-07 30.2 5.3 2.3e-07 30.2 3.7 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.1 ESA10944.1 - 3.2e-07 29.9 8.2 3.2e-07 29.9 5.7 2.8 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA10944.1 - 4.3e-07 29.4 9.8 4.3e-07 29.4 6.8 2.9 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA10944.1 - 4.7e-05 23.4 6.2 4.7e-05 23.4 4.3 3.0 2 2 0 2 2 2 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 ESA10944.1 - 9.8e-05 21.9 7.6 9.8e-05 21.9 5.3 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.1 ESA10944.1 - 0.00025 20.7 5.5 0.00025 20.7 3.8 1.8 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.1 ESA10944.1 - 0.00029 20.6 9.7 0.00029 20.6 6.7 2.5 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 ESA10944.1 - 0.00098 18.9 2.3 0.00098 18.9 1.6 1.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.10 ESA10944.1 - 0.046 13.6 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 U-box domain zf-RING_4 PF14570.1 ESA10944.1 - 0.1 12.2 0.6 0.1 12.2 0.4 3.2 3 1 0 3 3 2 0 RING/Ubox like zinc-binding domain Sina PF03145.11 ESA10944.1 - 0.81 9.3 11.5 2 8.0 2.6 2.6 2 1 1 3 3 3 0 Seven in absentia protein family bZIP_1 PF00170.16 ESA10945.1 - 6.2e-05 22.8 6.6 0.047 13.6 1.7 2.5 2 1 0 2 2 2 2 bZIP transcription factor Vps5 PF09325.5 ESA10945.1 - 0.0015 17.8 2.7 0.0017 17.6 1.9 1.1 1 0 0 1 1 1 1 Vps5 C terminal like HALZ PF02183.13 ESA10945.1 - 0.0024 17.5 5.3 0.0076 15.9 1.4 2.6 2 1 1 3 3 3 1 Homeobox associated leucine zipper BLOC1_2 PF10046.4 ESA10945.1 - 0.01 15.9 3.5 0.99 9.5 0.4 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2353 PF09789.4 ESA10945.1 - 0.022 14.0 2.0 1.6 7.9 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) Baculo_PEP_C PF04513.7 ESA10945.1 - 0.055 13.2 5.4 0.35 10.6 1.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_2 PF07716.10 ESA10945.1 - 0.071 12.9 8.7 0.22 11.3 2.6 2.4 2 0 0 2 2 2 0 Basic region leucine zipper Seryl_tRNA_N PF02403.17 ESA10945.1 - 0.083 12.9 1.6 0.58 10.1 0.3 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Sec2p PF06428.6 ESA10945.1 - 0.11 12.4 7.0 0.14 12.0 0.8 2.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p HAP1_N PF04849.8 ESA10945.1 - 0.11 11.4 5.4 0.13 11.1 3.7 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region LPP PF04728.8 ESA10945.1 - 0.15 11.8 0.2 0.4 10.5 0.2 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper ADIP PF11559.3 ESA10945.1 - 0.17 11.8 6.6 0.21 11.4 1.2 2.3 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding KIAA1430 PF13879.1 ESA10945.1 - 0.22 11.9 3.5 5.2 7.5 0.4 2.3 2 0 0 2 2 2 0 KIAA1430 homologue CENP-F_leu_zip PF10473.4 ESA10945.1 - 0.23 11.3 4.7 1 9.2 0.5 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.10 ESA10945.1 - 0.26 10.8 6.3 0.12 11.8 1.4 2.2 2 1 0 2 2 2 0 Septum formation initiator DUF904 PF06005.7 ESA10945.1 - 0.26 11.5 5.2 0.51 10.6 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) IFP_35_N PF07334.8 ESA10945.1 - 0.34 10.9 4.1 5.8 6.9 0.5 2.6 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus GAS PF13851.1 ESA10945.1 - 0.35 10.0 6.2 3.9 6.6 2.4 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF972 PF06156.8 ESA10945.1 - 0.43 10.9 3.5 2.1 8.7 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Prefoldin PF02996.12 ESA10945.1 - 0.71 9.5 4.9 5.3 6.7 0.7 2.1 2 0 0 2 2 2 0 Prefoldin subunit Tropomyosin_1 PF12718.2 ESA10945.1 - 0.88 9.4 5.3 0.29 10.9 1.5 1.6 1 1 0 2 2 2 0 Tropomyosin like FlaC_arch PF05377.6 ESA10945.1 - 0.94 9.4 6.8 5.6 6.9 0.8 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.6 ESA10945.1 - 1.1 9.6 3.7 1.9 8.9 0.8 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TSC22 PF01166.13 ESA10945.1 - 1.4 8.8 4.6 0.91 9.5 0.4 2.5 2 1 0 2 2 2 0 TSC-22/dip/bun family TBPIP PF07106.8 ESA10945.1 - 2.5 7.6 6.6 36 3.8 0.2 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4618 PF15397.1 ESA10945.1 - 2.5 7.3 7.3 4.8 6.4 4.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DivIVA PF05103.8 ESA10945.1 - 2.8 8.0 7.0 1.8 8.6 1.7 2.1 1 1 0 2 2 2 0 DivIVA protein Shugoshin_N PF07558.6 ESA10945.1 - 3.4 7.4 9.7 0.23 11.1 2.9 1.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Rootletin PF15035.1 ESA10945.1 - 3.9 7.4 10.5 3.4 7.6 2.7 2.1 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Pkinase_Tyr PF07714.12 ESA10946.1 - 1.2e-30 106.4 0.1 7.2e-28 97.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA10946.1 - 1.2e-29 103.3 2.6 5.7e-27 94.4 0.5 2.4 2 1 0 2 2 2 2 Protein kinase domain WaaY PF06176.6 ESA10946.1 - 0.013 14.7 1.9 0.018 14.2 0.5 1.8 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) PsbU PF06514.6 ESA10946.1 - 0.014 15.2 0.2 0.069 13.0 0.0 2.3 2 1 1 3 3 3 0 Photosystem II 12 kDa extrinsic protein (PsbU) BCS1_N PF08740.6 ESA10946.1 - 0.02 14.5 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 BCS1 N terminal Baculo_PEP_C PF04513.7 ESA10947.1 - 6e-05 22.8 3.9 0.13 12.0 1.1 2.1 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.13 ESA10947.1 - 0.0002 20.9 1.9 0.00073 19.0 1.3 1.8 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Med11 PF10280.4 ESA10947.1 - 0.0053 16.7 3.6 0.6 10.1 0.2 2.3 1 1 1 2 2 2 1 Mediator complex protein DUF1664 PF07889.7 ESA10947.1 - 0.0059 16.4 2.7 0.0059 16.4 1.9 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) CALCOCO1 PF07888.6 ESA10947.1 - 0.0065 14.8 4.3 0.007 14.7 3.0 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Tup_N PF08581.5 ESA10947.1 - 0.0083 16.2 5.4 1.9 8.7 0.0 2.5 2 1 0 2 2 2 2 Tup N-terminal DUF2317 PF10079.4 ESA10947.1 - 0.0084 14.7 1.5 0.0095 14.5 1.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2317) CAF1 PF04857.15 ESA10947.1 - 0.013 14.8 0.7 0.019 14.3 0.4 1.3 1 1 0 1 1 1 0 CAF1 family ribonuclease DUF1351 PF07083.6 ESA10947.1 - 0.024 14.2 2.1 0.05 13.2 1.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1351) COG2 PF06148.6 ESA10947.1 - 0.03 14.2 4.2 0.44 10.4 2.9 2.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 V_ATPase_I PF01496.14 ESA10947.1 - 0.036 11.9 3.1 0.08 10.7 2.2 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family ApoLp-III PF07464.6 ESA10947.1 - 0.041 13.9 4.7 0.15 12.0 3.2 1.8 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) NPV_P10 PF05531.7 ESA10947.1 - 0.042 14.1 3.4 0.92 9.7 0.9 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin_2 PF14523.1 ESA10947.1 - 0.058 13.4 8.2 0.68 9.9 5.6 2.4 1 1 0 1 1 1 0 Syntaxin-like protein OmpH PF03938.9 ESA10947.1 - 0.066 13.1 2.8 0.12 12.2 1.9 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Carbpep_Y_N PF05388.6 ESA10947.1 - 0.07 13.2 1.3 0.26 11.4 0.4 2.0 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide DUF848 PF05852.6 ESA10947.1 - 0.075 12.8 2.6 0.083 12.7 1.0 1.7 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Med9 PF07544.8 ESA10947.1 - 0.078 12.7 6.2 0.19 11.4 0.4 2.9 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UXS1_N PF11803.3 ESA10947.1 - 0.093 12.5 5.4 0.62 9.8 0.5 2.8 1 1 2 3 3 3 0 UDP-glucuronate decarboxylase N-terminal SF-assemblin PF06705.6 ESA10947.1 - 0.1 11.7 9.8 1.9 7.5 1.8 2.1 1 1 1 2 2 2 0 SF-assemblin/beta giardin HSCB_C PF07743.8 ESA10947.1 - 0.12 12.9 2.6 11 6.5 0.3 2.6 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain DUF4164 PF13747.1 ESA10947.1 - 0.16 12.1 2.6 0.47 10.6 1.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) Tektin PF03148.9 ESA10947.1 - 0.17 10.3 4.0 0.31 9.5 1.1 1.9 1 1 1 2 2 2 0 Tektin family Striatin PF08232.7 ESA10947.1 - 0.25 11.6 4.7 0.41 10.9 3.2 1.3 1 0 0 1 1 1 0 Striatin family DUF2884 PF11101.3 ESA10947.1 - 0.26 10.6 6.2 1 8.6 4.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) Laminin_II PF06009.7 ESA10947.1 - 0.26 11.0 7.3 0.6 9.8 1.7 2.2 1 1 1 2 2 2 0 Laminin Domain II YtxH PF12732.2 ESA10947.1 - 0.5 10.7 2.1 9.7 6.6 1.4 2.2 1 1 0 1 1 1 0 YtxH-like protein Mer2 PF09074.5 ESA10947.1 - 0.73 9.7 12.6 0.13 12.2 2.6 2.1 1 1 2 3 3 3 0 Mer2 Fib_alpha PF08702.5 ESA10947.1 - 0.77 9.8 5.3 7.8 6.6 3.7 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PRESAN PF09687.5 ESA10947.1 - 0.81 9.7 7.4 11 6.1 5.0 2.3 1 1 0 1 1 1 0 Plasmodium RESA N-terminal Pox_A_type_inc PF04508.7 ESA10947.1 - 1 9.3 8.9 0.74 9.7 0.5 3.4 3 1 0 3 3 2 0 Viral A-type inclusion protein repeat DUF3461 PF11944.3 ESA10947.1 - 1.1 9.1 6.1 5.3 6.9 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) Fzo_mitofusin PF04799.8 ESA10947.1 - 1.1 8.5 4.8 9.7 5.5 0.5 2.2 1 1 1 2 2 2 0 fzo-like conserved region Syntaxin-6_N PF09177.6 ESA10947.1 - 1.4 9.3 4.3 10 6.6 0.6 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Tropomyosin_1 PF12718.2 ESA10947.1 - 1.7 8.4 9.7 8.3 6.2 2.8 2.1 2 0 0 2 2 2 0 Tropomyosin like MbeB_N PF04837.7 ESA10947.1 - 2.2 8.4 8.1 3.2 7.9 1.2 2.8 2 1 1 3 3 2 0 MbeB-like, N-term conserved region HSBP1 PF06825.7 ESA10947.1 - 2.3 7.8 8.2 18 5.0 0.1 3.3 2 1 1 3 3 3 0 Heat shock factor binding protein 1 Syntaxin PF00804.20 ESA10947.1 - 2.9 8.1 7.5 45 4.2 5.2 2.5 1 1 0 1 1 1 0 Syntaxin FlaC_arch PF05377.6 ESA10947.1 - 6.5 6.7 17.7 4.4 7.2 0.3 3.6 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Apolipoprotein PF01442.13 ESA10948.1 - 2.6e-05 23.8 9.1 3.1e-05 23.5 6.3 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain MbeB_N PF04837.7 ESA10948.1 - 0.00043 20.3 14.1 0.0011 19.0 1.7 2.9 1 1 2 3 3 3 1 MbeB-like, N-term conserved region Baculo_PEP_C PF04513.7 ESA10948.1 - 0.00057 19.7 6.8 0.00072 19.4 4.7 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus CagA PF03507.8 ESA10948.1 - 0.00067 19.5 6.6 0.043 13.6 0.6 2.0 1 1 1 2 2 2 2 CagA exotoxin Syntaxin_2 PF14523.1 ESA10948.1 - 0.0038 17.2 11.0 0.013 15.5 6.0 2.0 1 1 1 2 2 2 1 Syntaxin-like protein HalX PF08663.5 ESA10948.1 - 0.006 16.5 4.3 0.38 10.7 0.7 2.6 1 1 2 3 3 3 1 HalX domain Prominin PF05478.6 ESA10948.1 - 0.0085 13.6 7.8 0.0092 13.5 5.4 1.0 1 0 0 1 1 1 1 Prominin DUF883 PF05957.8 ESA10948.1 - 0.015 15.6 2.0 0.027 14.8 1.2 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Carbpep_Y_N PF05388.6 ESA10948.1 - 0.016 15.3 7.8 0.26 11.4 1.1 2.0 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide Sec8_exocyst PF04048.9 ESA10948.1 - 0.017 14.7 5.3 0.022 14.3 3.7 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Mitofilin PF09731.4 ESA10948.1 - 0.019 13.6 18.4 0.023 13.3 12.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1664 PF07889.7 ESA10948.1 - 0.023 14.5 9.7 0.12 12.1 5.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2746 PF10874.3 ESA10948.1 - 0.024 14.8 7.5 0.98 9.6 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2746) DUF4455 PF14643.1 ESA10948.1 - 0.025 13.2 15.4 0.23 10.0 3.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4455) Leu_zip PF15294.1 ESA10948.1 - 0.028 13.5 14.4 0.51 9.4 3.6 2.1 1 1 1 2 2 2 0 Leucine zipper Fib_alpha PF08702.5 ESA10948.1 - 0.029 14.5 10.0 0.75 9.9 3.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.10 ESA10948.1 - 0.039 13.1 9.7 0.044 12.9 6.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.9 ESA10948.1 - 0.046 13.6 15.2 0.073 13.0 10.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PilJ PF13675.1 ESA10948.1 - 0.049 13.9 1.8 0.13 12.5 1.3 1.8 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term ATG_C PF09333.6 ESA10948.1 - 0.051 13.7 0.9 0.4 10.8 0.1 2.0 1 1 1 2 2 2 0 ATG C terminal domain Filament PF00038.16 ESA10948.1 - 0.052 12.9 13.2 0.075 12.4 9.1 1.2 1 0 0 1 1 1 0 Intermediate filament protein DUF4175 PF13779.1 ESA10948.1 - 0.056 11.1 9.4 0.065 10.9 6.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Mer2 PF09074.5 ESA10948.1 - 0.059 13.3 14.6 0.067 13.1 10.1 1.1 1 0 0 1 1 1 0 Mer2 DUF939_C PF11728.3 ESA10948.1 - 0.081 12.7 11.8 0.04 13.7 6.9 1.5 1 1 1 2 2 2 0 DUF939 C-terminal domain Mis12 PF05859.7 ESA10948.1 - 0.11 12.3 9.1 0.055 13.2 4.0 1.8 1 1 1 2 2 2 0 Mis12 protein DUF342 PF03961.8 ESA10948.1 - 0.11 10.8 16.6 0.11 10.8 11.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) WXG100 PF06013.7 ESA10948.1 - 0.11 12.4 7.4 0.57 10.2 5.1 2.2 1 1 0 1 1 1 0 Proteins of 100 residues with WXG COG2 PF06148.6 ESA10948.1 - 0.12 12.2 9.7 1.9 8.3 6.5 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 ESA10948.1 - 0.12 12.1 9.1 1.5 8.6 1.5 2.7 1 1 1 2 2 2 0 Vps51/Vps67 Med11 PF10280.4 ESA10948.1 - 0.14 12.1 12.4 1.6 8.7 4.5 2.1 1 1 1 2 2 2 0 Mediator complex protein DUF148 PF02520.12 ESA10948.1 - 0.15 11.9 11.3 0.27 11.0 7.8 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF651 PF04895.7 ESA10948.1 - 0.16 11.6 4.2 1.6 8.4 0.2 2.1 1 1 1 2 2 2 0 Archaeal protein of unknown function (DUF651) BMFP PF04380.8 ESA10948.1 - 0.19 11.9 7.6 2.3 8.3 1.2 2.2 1 1 1 2 2 2 0 Membrane fusogenic activity DUF2317 PF10079.4 ESA10948.1 - 0.2 10.2 9.1 0.21 10.1 6.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) DUF1640 PF07798.6 ESA10948.1 - 0.24 11.4 14.4 0.3 11.0 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) ACCA PF03255.9 ESA10948.1 - 0.24 10.9 9.0 0.81 9.2 1.6 2.0 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit HAUS-augmin3 PF14932.1 ESA10948.1 - 0.25 10.4 13.1 0.28 10.3 9.1 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Laminin_II PF06009.7 ESA10948.1 - 0.26 11.0 10.9 0.53 10.0 7.4 1.6 1 1 0 1 1 1 0 Laminin Domain II RRF_GI PF12614.3 ESA10948.1 - 0.26 11.0 4.8 0.2 11.4 1.6 1.7 1 1 1 2 2 2 0 Ribosome recycling factor AAA_13 PF13166.1 ESA10948.1 - 0.26 9.6 11.9 0.29 9.5 8.3 1.0 1 0 0 1 1 1 0 AAA domain Syntaxin PF00804.20 ESA10948.1 - 0.35 11.0 14.3 0.45 10.7 9.9 1.2 1 0 0 1 1 1 0 Syntaxin YtxH PF12732.2 ESA10948.1 - 0.35 11.2 6.6 11 6.5 4.6 2.1 1 1 0 1 1 1 0 YtxH-like protein ZYG-11_interact PF05884.7 ESA10948.1 - 0.37 9.8 3.5 0.44 9.5 2.4 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 Syntaxin-6_N PF09177.6 ESA10948.1 - 0.38 11.1 9.1 1 9.8 6.3 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal ATP-synt_B PF00430.13 ESA10948.1 - 0.38 10.5 12.7 0.56 10.0 7.6 1.8 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Vps54 PF07928.7 ESA10948.1 - 0.39 10.8 1.9 1.5 8.9 0.6 1.9 1 1 1 2 2 2 0 Vps54-like protein DASH_Ask1 PF08655.5 ESA10948.1 - 0.41 10.5 3.6 2 8.3 0.1 2.3 2 1 0 2 2 2 0 DASH complex subunit Ask1 Maf1 PF09174.5 ESA10948.1 - 0.44 10.3 7.0 1.7 8.4 0.5 2.1 1 1 1 2 2 2 0 Maf1 regulator TBPIP PF07106.8 ESA10948.1 - 0.5 9.8 16.6 0.54 9.7 11.5 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) YPEB PF14620.1 ESA10948.1 - 0.52 9.2 8.2 0.62 9.0 5.7 1.2 1 0 0 1 1 1 0 YpeB sporulation DUF3584 PF12128.3 ESA10948.1 - 0.53 7.5 12.0 0.57 7.4 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HSCB_C PF07743.8 ESA10948.1 - 0.59 10.6 14.8 2.5 8.6 2.7 2.1 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain Ran-binding PF05508.6 ESA10948.1 - 0.61 8.9 7.8 0.79 8.5 5.4 1.3 1 0 0 1 1 1 0 RanGTP-binding protein Synaptobrevin PF00957.16 ESA10948.1 - 0.64 9.6 16.7 0.81 9.3 0.9 3.0 1 1 2 3 3 3 0 Synaptobrevin Het-C PF07217.6 ESA10948.1 - 0.66 8.0 7.2 0.68 8.0 5.0 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Ded_cyto PF06920.8 ESA10948.1 - 0.68 9.2 7.6 1.1 8.5 5.2 1.5 1 1 0 1 1 1 0 Dedicator of cytokinesis DUF972 PF06156.8 ESA10948.1 - 0.7 10.2 15.8 4.6 7.6 10.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) MCM_N PF14551.1 ESA10948.1 - 0.71 10.3 3.9 0.87 10.0 2.7 1.2 1 0 0 1 1 1 0 MCM N-terminal domain DUF1444 PF07285.6 ESA10948.1 - 0.79 8.9 7.7 0.98 8.6 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1444) DUF3763 PF12592.3 ESA10948.1 - 0.85 9.2 9.9 1.8 8.2 0.4 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3763) ENT PF03735.9 ESA10948.1 - 0.87 9.3 5.7 3.5 7.4 0.6 2.2 1 1 1 2 2 2 0 ENT domain PEP-utilisers_N PF05524.8 ESA10948.1 - 0.88 9.3 5.7 11 5.8 4.0 2.0 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF1451 PF07295.6 ESA10948.1 - 0.9 9.3 8.6 1.1 9.0 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) DUF3452 PF11934.3 ESA10948.1 - 0.91 8.8 5.5 0.76 9.1 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3452) DUF2077 PF09850.4 ESA10948.1 - 1 8.6 3.6 6.5 6.1 0.3 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2077) DUF4246 PF14033.1 ESA10948.1 - 1.2 7.7 8.1 1.3 7.5 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) DUF1525 PF07511.6 ESA10948.1 - 1.2 9.1 5.2 3.7 7.5 3.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1525) ISG65-75 PF11727.3 ESA10948.1 - 1.3 8.0 7.1 1.4 7.8 4.9 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein DXP_synthase_N PF13292.1 ESA10948.1 - 1.3 7.9 4.7 1.6 7.6 3.3 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Allexi_40kDa PF05549.6 ESA10948.1 - 1.3 8.2 5.0 1.5 8.0 3.5 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF465 PF04325.8 ESA10948.1 - 1.4 8.7 10.8 4.3 7.1 1.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF465) HSBP1 PF06825.7 ESA10948.1 - 1.4 8.5 16.0 4.2e+02 0.6 11.1 3.1 1 1 0 1 1 1 0 Heat shock factor binding protein 1 V_ATPase_I PF01496.14 ESA10948.1 - 1.5 6.5 10.0 2.1 6.0 7.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LXG PF04740.7 ESA10948.1 - 1.6 8.5 11.2 4 7.1 7.7 1.6 1 1 0 1 1 1 0 LXG domain of WXG superfamily Hormone_1 PF00103.15 ESA10948.1 - 1.6 8.0 7.9 2 7.7 5.5 1.1 1 0 0 1 1 1 0 Somatotropin hormone family YlqD PF11068.3 ESA10948.1 - 1.7 8.6 16.2 3.1 7.8 11.3 1.5 1 1 0 1 1 1 0 YlqD protein TMPIT PF07851.8 ESA10948.1 - 1.8 7.5 9.3 2 7.3 6.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF2450 PF10475.4 ESA10948.1 - 1.9 7.3 9.3 2.8 6.7 6.5 1.4 1 1 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) DUF3461 PF11944.3 ESA10948.1 - 2.2 8.1 10.5 1 9.2 5.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) FlaC_arch PF05377.6 ESA10948.1 - 2.2 8.2 21.5 4.6e+03 -2.4 14.9 3.0 1 1 0 1 1 0 0 Flagella accessory protein C (FlaC) DUF1090 PF06476.7 ESA10948.1 - 2.3 7.9 11.2 20 4.8 7.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1090) Lipoprotein_20 PF13942.1 ESA10948.1 - 2.5 7.5 8.9 3.6 7.1 6.2 1.2 1 0 0 1 1 1 0 YfhG lipoprotein DUF2203 PF09969.4 ESA10948.1 - 2.6 8.2 10.1 1.5 9.0 3.6 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF948 PF06103.6 ESA10948.1 - 2.7 7.8 7.1 13 5.7 1.6 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) GrpE PF01025.14 ESA10948.1 - 2.8 7.4 13.0 6.8 6.2 9.0 1.6 1 1 0 1 1 1 0 GrpE EF-1_beta_acid PF10587.4 ESA10948.1 - 2.8 8.1 6.6 6 7.0 0.4 3.0 2 1 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region Fzo_mitofusin PF04799.8 ESA10948.1 - 2.9 7.2 12.4 46 3.3 8.6 2.0 1 1 0 1 1 1 0 fzo-like conserved region MutS_IV PF05190.13 ESA10948.1 - 3 8.0 10.5 2.5 8.3 1.8 2.4 1 1 1 2 2 2 0 MutS family domain IV Cluap1 PF10234.4 ESA10948.1 - 3.2 6.8 13.1 15 4.6 9.1 1.7 1 1 0 1 1 1 0 Clusterin-associated protein-1 Phage_GP20 PF06810.6 ESA10948.1 - 3.3 7.1 15.0 8 5.8 10.3 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 BEX PF04538.7 ESA10948.1 - 3.3 7.9 10.9 4.1 7.6 7.6 1.2 1 0 0 1 1 1 0 Brain expressed X-linked like family PCRF PF03462.13 ESA10948.1 - 3.3 7.4 12.5 8.4 6.1 2.0 2.2 1 1 1 2 2 2 0 PCRF domain DNA_primase_lrg PF04104.9 ESA10948.1 - 3.3 6.9 11.4 3.7 6.7 2.3 1.9 1 1 1 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit KfrA_N PF11740.3 ESA10948.1 - 3.4 8.1 5.7 8.4 6.8 4.0 1.6 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term Baculo_p24 PF05073.7 ESA10948.1 - 3.5 7.1 8.5 4 6.9 5.9 1.1 1 0 0 1 1 1 0 Baculovirus P24 capsid protein AAA_32 PF13654.1 ESA10948.1 - 3.5 6.1 11.5 7.1 5.1 8.0 1.5 1 1 0 1 1 1 0 AAA domain AHSP PF09236.5 ESA10948.1 - 3.8 7.7 7.1 4.4 7.5 0.9 2.1 1 1 1 2 2 2 0 Alpha-haemoglobin stabilising protein Band_7 PF01145.20 ESA10948.1 - 3.9 7.3 6.1 5.8 6.7 0.5 2.0 1 1 1 2 2 2 0 SPFH domain / Band 7 family YfcL PF08891.6 ESA10948.1 - 3.9 7.5 10.3 3.4 7.7 1.6 2.2 1 1 1 2 2 2 0 YfcL protein ALMT PF11744.3 ESA10948.1 - 4 5.9 8.0 4.2 5.9 5.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Phage_GPO PF05929.6 ESA10948.1 - 4.1 6.5 7.6 8.7 5.5 5.3 1.6 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase GBP_C PF02841.9 ESA10948.1 - 4.1 6.5 18.0 4.3 6.4 12.5 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Fmp27_WPPW PF10359.4 ESA10948.1 - 4.8 5.4 11.3 5.1 5.4 7.8 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain CCDC-167 PF15188.1 ESA10948.1 - 5.4 7.0 15.5 7.7 6.5 10.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 eIF-4B PF06273.6 ESA10948.1 - 5.5 5.6 12.4 10 4.7 8.6 1.5 1 1 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF2362 PF10154.4 ESA10948.1 - 5.6 5.5 13.1 6.1 5.3 9.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) DUF3086 PF11285.3 ESA10948.1 - 5.8 5.6 8.3 22 3.7 5.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3086) Mgr1 PF08602.5 ESA10948.1 - 6 5.7 8.4 7.5 5.4 5.8 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit UXS1_N PF11803.3 ESA10948.1 - 6.3 6.6 8.2 4e+02 0.8 5.7 2.6 1 1 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal Vfa1 PF08432.5 ESA10948.1 - 6.4 6.7 8.6 9.1 6.2 6.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CEP19 PF14933.1 ESA10948.1 - 6.5 7.0 10.4 7.5 6.8 7.2 1.1 1 0 0 1 1 1 0 CEP19-like protein ParB PF08775.5 ESA10948.1 - 6.7 7.0 10.8 17 5.7 4.6 2.1 1 1 1 2 2 2 0 ParB family PRKCSH-like PF12999.2 ESA10948.1 - 6.8 6.2 7.5 8.8 5.8 5.2 1.2 1 0 0 1 1 1 0 Glucosidase II beta subunit-like CR6_interact PF10147.4 ESA10948.1 - 7.1 5.8 11.6 9.3 5.5 8.1 1.2 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 APG6 PF04111.7 ESA10948.1 - 7.6 5.4 15.7 8.9 5.2 10.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 GvpL_GvpF PF06386.6 ESA10948.1 - 8.1 5.9 7.3 12 5.4 5.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Rbsn PF11464.3 ESA10948.1 - 8.8 5.9 20.7 4.4 6.9 2.6 4.5 1 1 3 4 4 4 0 Rabenosyn Rab binding domain Imm42 PF15601.1 ESA10948.1 - 9.2 5.6 7.9 8.7 5.7 0.7 2.1 1 1 1 2 2 2 0 Immunity protein 42 DUF745 PF05335.8 ESA10948.1 - 9.4 5.7 10.8 12 5.3 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) zf-CCCH PF00642.19 ESA10949.1 - 1.1e-20 72.8 17.9 2.1e-10 40.0 3.0 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) NUDIX PF00293.23 ESA10949.1 - 4.9e-11 42.4 0.0 9.2e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain zf-CCCH_2 PF14608.1 ESA10949.1 - 0.021 14.8 8.2 0.45 10.5 0.7 2.4 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type CENP_C_N PF15622.1 ESA10951.1 - 0.017 14.3 0.1 0.019 14.2 0.1 1.0 1 0 0 1 1 1 0 Kinetochore assembly subunit CENP-C N-terminal DUF3317 PF11779.3 ESA10952.1 - 0.096 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Staphostatin_A PF09022.5 ESA10953.1 - 0.07 12.9 1.3 0.093 12.5 0.9 1.2 1 0 0 1 1 1 0 Staphostatin A Gemini_AL1 PF00799.15 ESA10954.1 - 3.8e-20 71.8 0.0 1.1e-19 70.4 0.0 1.7 2 0 0 2 2 2 1 Geminivirus Rep catalytic domain RNA_helicase PF00910.17 ESA10954.1 - 0.01 16.0 0.0 0.033 14.3 0.0 1.9 1 1 0 1 1 1 0 RNA helicase Gemini_AL1_M PF08283.6 ESA10954.1 - 0.011 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 Geminivirus rep protein central domain AAA_22 PF13401.1 ESA10954.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA10954.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain MCM PF00493.18 ESA10957.1 - 1.2e-123 412.1 0.1 2.1e-123 411.3 0.1 1.3 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 ESA10957.1 - 5.8e-18 65.3 27.9 5.8e-18 65.3 19.3 1.7 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 ESA10957.1 - 9.1e-18 64.8 0.6 2.8e-17 63.3 0.4 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESA10957.1 - 1e-08 34.6 0.0 7.8e-07 28.4 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESA10957.1 - 4.1e-05 23.3 0.0 9.6e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 ESA10957.1 - 0.00018 21.1 0.0 0.00056 19.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESA10957.1 - 0.00096 18.6 0.1 0.014 14.9 0.0 2.4 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.24 ESA10957.1 - 0.086 13.0 0.0 0.31 11.2 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HMG_box PF00505.14 ESA10958.1 - 1.5e-09 38.0 0.1 2.8e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HHH_3 PF12836.2 ESA10960.1 - 3.3e-05 23.7 0.0 5.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_6 PF14579.1 ESA10960.1 - 0.048 13.7 0.0 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif DDE_3 PF13358.1 ESA10961.1 - 4.4e-12 45.9 0.1 4.7e-12 45.8 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease AAA_13 PF13166.1 ESA10961.1 - 0.12 10.8 0.1 0.13 10.7 0.1 1.0 1 0 0 1 1 1 0 AAA domain ELYS PF13934.1 ESA10962.1 - 6.4e-06 26.0 1.2 9.3e-06 25.5 0.8 1.2 1 0 0 1 1 1 1 Nuclear pore complex assembly GIDA PF01134.17 ESA10962.1 - 0.087 11.6 0.7 0.15 10.9 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AATF-Che1 PF13339.1 ESA10962.1 - 0.16 12.1 9.4 1 9.5 3.2 2.3 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor TPR_2 PF07719.12 ESA10963.1 - 1.4e-18 65.1 10.5 0.0024 17.6 0.0 10.7 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_11 PF13414.1 ESA10963.1 - 1.2e-17 63.3 13.8 1.9e-05 24.2 0.0 7.8 5 2 3 8 8 8 5 TPR repeat TPR_1 PF00515.23 ESA10963.1 - 3.5e-15 54.8 14.0 0.0025 17.3 0.0 9.7 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA10963.1 - 8e-13 48.6 0.1 0.0011 19.6 0.0 7.0 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA10963.1 - 4.3e-11 42.4 2.1 0.14 12.9 0.0 8.2 7 2 4 11 11 8 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA10963.1 - 9.8e-11 40.6 16.1 0.32 10.8 0.0 9.4 9 2 2 11 11 10 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA10963.1 - 2.5e-09 36.9 14.1 0.00042 20.2 0.1 7.4 5 1 2 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA10963.1 - 3.6e-09 36.6 6.9 0.0033 17.5 0.0 6.0 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESA10963.1 - 3.8e-09 36.0 0.4 5.7 7.3 0.0 6.9 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA10963.1 - 6.6e-08 32.7 9.5 6.9e-05 23.1 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA10963.1 - 7e-07 28.5 1.9 0.46 10.4 0.0 7.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA10963.1 - 0.0062 16.9 6.2 9.3 6.9 0.0 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat PHP_C PF13263.1 ESA10963.1 - 0.14 11.6 0.6 0.37 10.3 0.0 2.1 2 0 0 2 2 2 0 PHP-associated Phage_hub_GP28 PF11110.3 ESA10964.1 - 0.11 12.2 0.1 0.27 10.9 0.1 1.6 1 1 0 1 1 1 0 Baseplate hub distal subunit Whirly PF08536.6 ESA10965.1 - 0.029 13.8 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Whirly transcription factor Pkinase_Tyr PF07714.12 ESA10965.1 - 0.044 12.8 0.0 0.076 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase DUF972 PF06156.8 ESA10966.1 - 0.0053 17.0 0.4 0.0092 16.3 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF972) FlaC_arch PF05377.6 ESA10966.1 - 0.03 14.2 0.2 0.25 11.2 0.1 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1319 PF07028.6 ESA10966.1 - 0.097 12.8 0.0 1.1 9.4 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Mod_r PF07200.8 ESA10966.1 - 0.13 12.2 0.9 0.17 11.7 0.2 1.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Dimer_Tnp_hAT PF05699.9 ESA10967.1 - 0.00019 20.9 0.2 0.0004 19.9 0.0 1.7 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region NRDD PF13597.1 ESA10968.1 - 0.013 13.5 0.0 0.013 13.5 0.0 1.0 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Borrelia_lipo_1 PF05714.6 ESA10968.1 - 0.056 12.5 0.5 0.44 9.6 0.1 1.9 1 1 1 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein Pkinase_Tyr PF07714.12 ESA10969.1 - 1.2e-24 86.7 0.0 1.4e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA10969.1 - 8.3e-20 71.0 0.0 9.6e-20 70.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Cu-binding_MopE PF11617.3 ESA10969.1 - 0.11 12.3 0.5 0.32 10.8 0.1 1.9 2 0 0 2 2 2 0 Protein metal binding site Pkinase PF00069.20 ESA10970.1 - 5.8e-30 104.3 0.1 6.7e-30 104.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10970.1 - 1.2e-27 96.6 0.0 1.3e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA10970.1 - 2.1e-05 23.6 0.0 3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA10970.1 - 4.7e-05 22.8 0.0 5.6e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA10970.1 - 0.00081 18.5 0.1 0.0011 18.1 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA10970.1 - 0.014 15.0 0.7 0.023 14.2 0.5 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase WaaY PF06176.6 ESA10970.1 - 0.024 13.8 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA10970.1 - 0.041 13.6 0.3 0.1 12.3 0.1 1.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3557 PF12078.3 ESA10972.1 - 0.0013 18.5 2.3 0.0013 18.5 1.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3557) Rad4 PF03835.10 ESA10972.1 - 0.027 13.8 0.0 0.05 12.9 0.0 1.4 1 0 0 1 1 1 0 Rad4 transglutaminase-like domain DUF4116 PF13475.1 ESA10973.1 - 0.29 10.6 3.0 0.3 10.6 0.4 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4116) Dimer_Tnp_hAT PF05699.9 ESA10974.1 - 1.5e-07 30.8 1.2 2.2e-07 30.3 0.8 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Dimer_Tnp_hAT PF05699.9 ESA10975.1 - 0.073 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region SET PF00856.23 ESA10976.1 - 4.6e-17 62.8 0.0 9.2e-17 61.8 0.0 1.5 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.6 ESA10976.1 - 0.0038 17.1 0.4 0.012 15.4 0.2 1.8 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding DegV PF02645.11 ESA10976.1 - 0.017 14.2 0.1 0.029 13.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 Pkinase PF00069.20 ESA10977.1 - 5.1e-39 133.9 0.0 6.7e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA10977.1 - 5.7e-16 58.3 0.0 7.5e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA10977.1 - 8e-06 25.7 0.0 0.0039 16.9 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESA10977.1 - 0.014 14.2 0.1 0.021 13.6 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase FAM220 PF15487.1 ESA10977.1 - 0.085 12.2 1.2 0.13 11.6 0.8 1.1 1 0 0 1 1 1 0 FAM220 family DUF3307 PF11750.3 ESA10981.1 - 0.11 12.2 0.2 0.21 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3307) p450 PF00067.17 ESA10982.1 - 4.5e-39 134.2 0.1 5.6e-39 133.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA10982.1 - 0.019 14.8 0.1 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) Methyltransf_14 PF08484.6 ESA10983.1 - 0.091 12.3 0.0 0.96 8.9 0.0 2.1 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain Corona_nucleoca PF00937.13 ESA10984.1 - 1.4 7.8 6.2 1.5 7.6 4.3 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Myb_DNA-bind_4 PF13837.1 ESA10985.1 - 2.6e-09 37.0 0.0 2.8e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA10985.1 - 0.00018 22.0 0.1 0.00022 21.7 0.1 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA10985.1 - 0.0037 17.1 0.0 0.0046 16.8 0.0 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain rve_3 PF13683.1 ESA10985.1 - 0.0061 16.0 0.1 0.0098 15.3 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain MADF_DNA_bdg PF10545.4 ESA10985.1 - 0.0074 16.4 0.1 0.0088 16.2 0.1 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like NinG PF05766.7 ESA10987.1 - 0.034 13.8 0.9 0.057 13.1 0.2 1.6 1 1 0 1 1 1 0 Bacteriophage Lambda NinG protein BUD22 PF09073.5 ESA10987.1 - 1.3 7.9 16.4 1.5 7.8 11.4 1.1 1 0 0 1 1 1 0 BUD22 LMBR1 PF04791.11 ESA10989.1 - 0.013 14.0 2.2 0.015 13.9 1.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3774 PF12609.3 ESA10989.1 - 1.2 9.9 4.8 1.8 9.4 3.3 1.2 1 0 0 1 1 1 0 Wound-induced protein TPX2 PF06886.6 ESA10989.1 - 1.5 8.9 8.4 0.28 11.2 3.3 1.6 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) Sel1 PF08238.7 ESA10990.1 - 4.4e-45 151.1 4.9 1.2e-11 44.8 0.2 5.2 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA10990.1 - 0.078 12.8 5.2 15 5.5 0.0 4.2 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3231 PF11553.3 ESA10990.1 - 0.086 12.3 0.7 0.27 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) zf-H2C2_2 PF13465.1 ESA10993.1 - 6.4e-06 26.1 2.7 6.4e-06 26.1 1.9 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA10993.1 - 0.001 19.2 4.0 0.22 11.9 0.4 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA10993.1 - 0.014 15.7 6.3 0.15 12.4 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-CHY PF05495.7 ESA10993.1 - 0.093 12.8 3.4 0.12 12.5 2.4 1.3 1 0 0 1 1 1 0 CHY zinc finger ZF-HD_dimer PF04770.7 ESA10993.1 - 0.25 11.4 3.2 6.2 6.9 0.2 2.1 1 1 1 2 2 2 0 ZF-HD protein dimerisation region CCAP PF11105.3 ESA10993.1 - 0.52 10.0 2.4 0.56 9.9 1.7 1.1 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a CHORD PF04968.7 ESA10993.1 - 0.86 9.8 8.0 2.8 8.2 1.3 2.1 1 1 1 2 2 2 0 CHORD zf-C2H2_6 PF13912.1 ESA10993.1 - 2.3 8.2 4.7 3.6 7.6 1.2 2.3 2 1 0 2 2 2 0 C2H2-type zinc finger Lipocalin_4 PF13648.1 ESA10995.1 - 6.6 7.4 7.5 0.76 10.4 1.1 2.2 2 2 0 2 2 2 0 Lipocalin-like domain UBN_AB PF14075.1 ESA10996.1 - 1.9 8.1 5.8 0.38 10.4 1.3 1.7 1 1 1 2 2 2 0 Ubinuclein conserved middle domain Herpes_LMP2 PF07415.6 ESA10996.1 - 9.1 4.7 6.0 12 4.3 4.2 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein IBR PF01485.16 ESA10997.1 - 6.6e-21 73.9 35.0 3.3e-14 52.5 1.7 3.8 3 1 1 4 4 4 3 IBR domain Pkinase_Tyr PF07714.12 ESA11004.1 - 4.8e-05 22.5 0.0 7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PuR_N PF09182.5 ESA11004.1 - 0.0076 15.8 0.1 0.015 14.8 0.1 1.5 1 0 0 1 1 1 1 Bacterial purine repressor, N-terminal Pkinase PF00069.20 ESA11004.1 - 0.03 13.4 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Arrestin_N PF00339.24 ESA11005.1 - 8.3e-14 51.6 1.2 3e-13 49.8 0.0 2.4 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA11005.1 - 1.2e-13 51.3 5.8 9e-12 45.2 3.2 2.6 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.2 ESA11005.1 - 1.4e-05 24.6 0.0 4.5e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Arrestin_N terminal like Abhydrolase_3 PF07859.8 ESA11006.1 - 0.0045 16.5 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold LTXXQ PF07813.7 ESA11007.1 - 0.00063 20.1 1.4 0.00093 19.6 0.8 1.5 1 1 0 1 1 1 1 LTXXQ motif family protein Prismane PF03063.15 ESA11008.1 - 0.14 10.4 0.1 0.15 10.4 0.0 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Kp4 PF09044.5 ESA11009.1 - 0.014 15.2 0.1 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Kp4 Pkinase PF00069.20 ESA11010.1 - 1.9e-20 73.1 1.3 3.4e-20 72.2 0.9 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11010.1 - 8.4e-16 57.8 0.2 2.5e-15 56.2 0.0 1.9 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESA11010.1 - 0.2 11.3 0.1 0.27 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA11011.1 - 2.5e-21 76.0 1.4 4.2e-21 75.2 0.9 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11011.1 - 8.1e-16 57.8 0.0 1.5e-15 56.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA11011.1 - 0.035 13.1 0.1 0.057 12.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA11011.1 - 0.051 13.3 0.2 0.077 12.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Biotin_carb_C PF02785.14 ESA11012.1 - 8.8e-31 106.0 0.0 2.1e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 ESA11012.1 - 1.7e-14 53.1 5.5 3.4e-14 52.2 3.8 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 ESA11012.1 - 7.5e-05 22.3 4.5 0.011 15.4 0.1 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like CPSase_L_D2 PF02786.12 ESA11012.1 - 0.00023 20.4 0.1 0.00051 19.4 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RnfC_N PF13375.1 ESA11012.1 - 0.0036 16.9 1.2 0.0077 15.9 0.9 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.1 ESA11012.1 - 0.0051 17.1 2.3 0.68 10.3 0.0 3.3 3 0 0 3 3 3 1 HlyD family secretion protein Glyco_hydro_65C PF03633.10 ESA11012.1 - 0.12 12.5 0.3 1.7 8.7 0.0 2.9 3 1 1 4 4 4 0 Glycosyl hydrolase family 65, C-terminal domain HlyD PF00529.15 ESA11012.1 - 0.12 11.6 3.3 0.38 10.0 0.0 2.2 2 0 0 2 2 2 0 HlyD family secretion protein DUF1034 PF06280.7 ESA11012.1 - 0.28 11.5 2.2 1.2 9.5 0.2 2.6 1 1 1 2 2 2 0 Fn3-like domain (DUF1034) APC_CDC26 PF10471.4 ESA11013.1 - 1.5e-08 35.2 9.1 2.1e-06 28.3 0.1 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex APC subunit 1 DUF1183 PF06682.7 ESA11014.1 - 1.6e-70 238.2 11.8 4.5e-70 236.7 8.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1183) UCH PF00443.24 ESA11015.1 - 3e-66 223.2 5.4 3e-66 223.2 3.7 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA11015.1 - 1.2e-29 103.7 9.6 1.2e-29 103.7 6.7 2.8 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2_jaz PF12171.3 ESA11016.1 - 2.4e-11 43.4 4.8 2.4e-11 43.4 3.4 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA11016.1 - 8e-08 32.2 4.7 8e-08 32.2 3.3 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESA11016.1 - 9.8e-08 32.0 4.8 0.0046 17.0 0.1 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 ESA11016.1 - 2.3e-05 24.4 7.2 0.041 14.2 0.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA11016.1 - 0.0002 21.5 8.5 0.03 14.6 0.7 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESA11016.1 - 0.0018 18.1 2.9 0.058 13.3 0.2 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-FCS PF06467.9 ESA11016.1 - 0.16 11.6 5.0 0.19 11.3 0.5 2.5 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif C1_4 PF07975.7 ESA11016.1 - 0.64 10.0 5.7 7.6 6.6 0.4 3.0 3 0 0 3 3 3 0 TFIIH C1-like domain Pkinase PF00069.20 ESA11018.1 - 1.6e-18 66.8 0.8 3.5e-18 65.7 0.6 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11018.1 - 3.4e-15 55.8 0.0 6.8e-15 54.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA11018.1 - 0.061 13.0 0.0 0.086 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ion_trans PF00520.26 ESA11020.1 - 0.076 12.2 10.7 0.14 11.3 7.4 1.5 1 1 0 1 1 1 0 Ion transport protein MnhB PF04039.8 ESA11020.1 - 0.17 11.9 1.8 0.36 10.8 1.2 1.5 1 0 0 1 1 1 0 Domain related to MnhB subunit of Na+/H+ antiporter Pkinase PF00069.20 ESA11021.1 - 8.9e-19 67.6 0.0 3.7e-18 65.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11021.1 - 1.6e-18 66.7 0.1 7.6e-18 64.5 0.0 2.2 2 1 1 3 3 3 1 Protein tyrosine kinase YchF-GTPase_C PF06071.8 ESA11021.1 - 0.01 15.6 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF933) Ribosomal_S27e PF01667.12 ESA11021.1 - 0.26 10.8 11.9 5.6 6.5 0.1 3.7 3 0 0 3 3 3 0 Ribosomal protein S27 Pkinase_Tyr PF07714.12 ESA11022.1 - 1.3e-09 37.5 0.1 2.5e-09 36.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11022.1 - 0.0011 18.2 0.0 0.0023 17.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF3216 PF11505.3 ESA11022.1 - 0.068 12.9 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) Mgr1 PF08602.5 ESA11022.1 - 0.11 11.5 2.1 0.12 11.3 1.5 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit ANTH PF07651.11 ESA11025.1 - 0.024 13.3 0.1 0.025 13.2 0.0 1.1 1 0 0 1 1 1 0 ANTH domain Sterile PF03015.14 ESA11025.1 - 0.058 13.6 0.2 0.06 13.6 0.1 1.2 1 0 0 1 1 1 0 Male sterility protein SSXRD PF09514.5 ESA11025.1 - 0.083 12.2 0.2 0.15 11.3 0.1 1.5 1 0 0 1 1 1 0 SSXRD motif DUF3169 PF11368.3 ESA11025.1 - 0.14 11.3 0.5 0.14 11.3 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DegQ PF08181.6 ESA11025.1 - 0.23 11.2 2.6 0.52 10.0 0.4 2.4 2 1 1 3 3 3 0 DegQ (SacQ) family Pkinase PF00069.20 ESA11026.1 - 1.9e-24 86.2 0.1 3.1e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11026.1 - 5.3e-24 84.6 0.0 8e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA11026.1 - 0.0086 15.1 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA11026.1 - 0.021 14.5 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2805 PF10985.3 ESA11027.1 - 0.017 15.0 0.8 0.043 13.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2805) Uteroglobin PF01099.12 ESA11028.1 - 0.067 13.0 0.5 0.073 12.8 0.3 1.2 1 0 0 1 1 1 0 Uteroglobin family Pkinase_Tyr PF07714.12 ESA11029.1 - 2.1e-14 53.2 0.0 3.6e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11029.1 - 1.3e-09 37.5 0.1 2.6e-09 36.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain zf-CHCC PF10276.4 ESA11029.1 - 0.39 10.6 5.7 0.82 9.5 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger domain Ribosomal_S14 PF00253.16 ESA11029.1 - 9.4 5.7 12.5 0.29 10.5 0.5 3.2 4 0 0 4 4 4 0 Ribosomal protein S14p/S29e DnaJ PF00226.26 ESA11030.1 - 3.9e-27 93.7 2.2 5.7e-27 93.2 1.5 1.2 1 0 0 1 1 1 1 DnaJ domain RNase_H PF00075.19 ESA11031.1 - 1.2e-13 51.5 0.0 2e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 RNase H RNase_H PF00075.19 ESA11033.1 - 2.1e-13 50.7 0.0 3.3e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 RNase H eRF1_2 PF03464.10 ESA11034.1 - 9.4e-05 22.7 0.0 0.00012 22.4 0.0 1.2 1 1 0 1 1 1 1 eRF1 domain 2 HTH_7 PF02796.10 ESA11034.1 - 0.064 13.1 0.1 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain of resolvase Pkinase_Tyr PF07714.12 ESA11036.1 - 1.5e-31 109.4 0.0 2e-28 99.1 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA11036.1 - 1.8e-28 99.3 0.6 1.8e-28 99.3 0.4 2.1 3 0 0 3 3 3 1 Protein kinase domain APH PF01636.18 ESA11036.1 - 0.0025 17.5 0.0 0.0044 16.7 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA11036.1 - 0.024 13.7 0.1 0.038 13.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SLIDE PF09111.5 ESA11036.1 - 0.082 12.6 0.7 9.6 5.9 0.0 2.8 2 0 0 2 2 2 0 SLIDE DUF4116 PF13475.1 ESA11036.1 - 0.11 11.9 3.6 30 4.2 0.1 4.4 3 2 1 4 4 4 0 Domain of unknown function (DUF4116) MFS_1 PF07690.11 ESA11037.1 - 1.2e-12 47.2 28.8 1.4e-12 46.9 15.3 3.0 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 ESA11037.1 - 8.7e-08 30.8 12.3 1.4e-07 30.1 8.0 1.8 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Mod_r PF07200.8 ESA11038.1 - 1 9.2 13.0 0.038 13.9 4.0 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4398 PF14346.1 ESA11038.1 - 4.9 7.2 10.4 7.4 6.6 1.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) DUF2331 PF10093.4 ESA11040.1 - 0.053 12.3 0.0 0.09 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2331) HMG_box PF00505.14 ESA11041.1 - 0.0066 16.6 2.2 0.012 15.8 1.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box DUF223 PF02721.9 ESA11041.1 - 0.14 12.2 1.3 0.25 11.4 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF223 DDE_3 PF13358.1 ESA11043.1 - 8.8e-06 25.5 0.0 9e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease F-box-like PF12937.2 ESA11044.1 - 0.002 17.8 1.0 0.0025 17.5 0.0 1.7 2 0 0 2 2 2 1 F-box-like Ndr PF03096.9 ESA11044.1 - 0.006 15.1 0.2 0.0085 14.6 0.1 1.2 1 0 0 1 1 1 1 Ndr family F-box PF00646.28 ESA11044.1 - 0.016 14.8 0.1 0.095 12.3 0.1 2.2 1 1 0 1 1 1 0 F-box domain Peptidase_M17 PF00883.16 ESA11045.1 - 1.3e-11 43.9 0.0 1.1e-05 24.5 0.0 2.0 1 1 1 2 2 2 2 Cytosol aminopeptidase family, catalytic domain F-box-like PF12937.2 ESA11046.1 - 0.00014 21.4 3.2 0.00014 21.4 2.2 2.8 3 0 0 3 3 3 1 F-box-like DUF2817 PF10994.3 ESA11049.1 - 0.067 12.2 0.1 0.071 12.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) Spc24 PF08286.6 ESA11050.1 - 5.5e-18 64.7 4.6 5.5e-18 64.7 3.2 2.2 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Med10 PF09748.4 ESA11050.1 - 0.021 14.6 1.3 0.055 13.2 0.9 1.8 1 1 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex PilJ PF13675.1 ESA11050.1 - 0.15 12.4 1.9 1.6 9.0 0.1 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF342 PF03961.8 ESA11050.1 - 0.52 8.6 10.5 0.67 8.2 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 ESA11050.1 - 0.6 7.8 8.7 0.65 7.7 6.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF-4B PF06273.6 ESA11050.1 - 1.4 7.5 8.9 1.9 7.1 6.2 1.3 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B TPR_MLP1_2 PF07926.7 ESA11050.1 - 5.1 6.8 19.0 38 4.0 13.1 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein PGI PF00342.14 ESA11051.1 - 8.6e-226 749.9 0.0 1e-225 749.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Hydrolase_6 PF13344.1 ESA11051.1 - 0.018 14.9 0.2 0.18 11.7 0.1 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase LRR_4 PF12799.2 ESA11052.1 - 2.6e-17 62.0 28.0 3e-06 26.7 0.2 6.2 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA11052.1 - 7.4e-14 51.2 23.7 2.1e-05 24.1 3.1 4.1 4 0 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ESA11052.1 - 1.4e-11 42.7 22.7 0.6 10.3 0.1 10.1 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_6 PF13516.1 ESA11052.1 - 4.3e-05 23.1 23.6 0.99 9.6 0.1 7.9 8 1 1 9 9 9 3 Leucine Rich repeat DUF4179 PF13786.1 ESA11052.1 - 0.005 17.0 0.8 0.026 14.7 0.6 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4179) LRRNT_2 PF08263.7 ESA11052.1 - 0.0062 16.4 0.2 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain Herpes_US9 PF06072.6 ESA11052.1 - 0.059 13.2 0.8 0.14 11.9 0.5 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 LRR_7 PF13504.1 ESA11052.1 - 0.074 13.2 16.2 45 4.8 0.1 8.5 9 0 0 9 9 9 0 Leucine rich repeat COX15-CtaA PF02628.10 ESA11052.1 - 0.18 10.6 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Cytochrome oxidase assembly protein DUF3899 PF13038.1 ESA11052.1 - 1.2 9.2 9.5 0.13 12.4 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Sipho_Gp157 PF05565.6 ESA11055.1 - 0.026 14.0 0.3 0.3 10.6 0.1 2.3 2 0 0 2 2 2 0 Siphovirus Gp157 NOB1_Zn_bind PF08772.6 ESA11055.1 - 0.039 13.7 1.1 0.039 13.7 0.8 3.3 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like HTH_30 PF13556.1 ESA11056.1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.3 1 1 0 1 1 1 0 PucR C-terminal helix-turn-helix domain COG5 PF10392.4 ESA11056.1 - 0.034 14.0 0.1 0.04 13.8 0.1 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Hemagglutinin PF00509.13 ESA11056.1 - 0.062 11.4 0.3 0.061 11.4 0.2 1.1 1 0 0 1 1 1 0 Haemagglutinin NYD-SP28 PF14772.1 ESA11056.1 - 0.096 12.7 0.0 0.18 11.9 0.0 1.4 1 1 0 1 1 1 0 Sperm tail HCV_NS4b PF01001.14 ESA11058.1 - 0.082 12.2 3.6 0.1 11.9 2.5 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4b Bacteriocin_IIc PF10439.4 ESA11058.1 - 0.9 9.7 16.0 1.7 8.8 11.1 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_OmpA PF13436.1 ESA11058.1 - 5.7 6.6 12.3 8.5 6.0 8.5 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain DUF3071 PF11268.3 ESA11059.1 - 0.013 15.1 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Gln-synt_N PF03951.14 ESA11060.1 - 0.057 12.9 11.6 4.8 6.8 0.3 3.6 1 1 2 3 3 3 0 Glutamine synthetase, beta-Grasp domain Vpu PF00558.14 ESA11062.1 - 0.028 13.9 1.5 0.035 13.6 1.1 1.2 1 0 0 1 1 1 0 Vpu protein Dimer_Tnp_hAT PF05699.9 ESA11063.1 - 1.4e-10 40.6 0.7 1.9e-10 40.2 0.5 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region IL1_propep PF02394.11 ESA11064.1 - 0.048 14.0 1.9 0.07 13.5 1.3 1.2 1 0 0 1 1 1 0 Interleukin-1 propeptide DUF1510 PF07423.6 ESA11064.1 - 0.06 12.6 3.3 0.067 12.5 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SMN PF06003.7 ESA11064.1 - 0.097 11.7 2.3 0.1 11.6 1.6 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) TRAP_alpha PF03896.11 ESA11064.1 - 0.96 8.3 4.3 1 8.2 3.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.4 ESA11064.1 - 3 6.4 10.8 3.6 6.2 7.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DDE_1 PF03184.14 ESA11065.1 - 1.2e-14 54.0 0.6 1.2e-14 53.9 0.4 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1706 PF08020.6 ESA11065.1 - 0.0092 15.4 0.4 0.01 15.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1706) HTH_Tnp_Tc5 PF03221.11 ESA11066.1 - 2.4e-08 33.6 1.1 1.5e-07 31.1 0.6 2.3 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA11066.1 - 0.001 18.4 1.7 0.0029 17.0 1.2 1.8 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain UvrC_HhH_N PF08459.6 ESA11066.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal DUF4373 PF14297.1 ESA11066.1 - 0.01 16.1 0.5 4.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) Sigma70_r4 PF04545.11 ESA11066.1 - 0.013 14.8 0.0 0.023 13.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Phage_terminase PF10668.4 ESA11066.1 - 0.052 13.3 0.4 0.11 12.2 0.3 1.7 1 0 0 1 1 1 0 Phage terminase small subunit Ribosomal_L2_C PF03947.13 ESA11067.1 - 2e-49 166.6 0.6 3.6e-49 165.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESA11067.1 - 9.9e-24 83.1 0.4 1.9e-23 82.2 0.3 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain MTS PF05175.9 ESA11068.1 - 9.3e-16 57.6 0.1 1.3e-15 57.2 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 ESA11068.1 - 2.9e-14 52.8 0.3 3.9e-14 52.4 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 ESA11068.1 - 1.4e-10 40.9 0.6 1.9e-10 40.4 0.4 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA11068.1 - 4e-10 39.7 0.0 5.3e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESA11068.1 - 1.1e-09 38.0 0.0 1.5e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.2 ESA11068.1 - 1.7e-07 31.7 0.0 2.4e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 ESA11068.1 - 2.1e-06 27.3 0.1 3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.1 ESA11068.1 - 8.1e-06 26.1 0.1 1.3e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.11 ESA11068.1 - 6e-05 22.1 0.0 6.5e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF43 Cons_hypoth95 PF03602.10 ESA11068.1 - 8e-05 22.1 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.7 ESA11068.1 - 0.00042 20.7 0.1 0.00078 19.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 ESA11068.1 - 0.00045 19.3 0.4 0.00066 18.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_11 PF08241.7 ESA11068.1 - 0.0008 19.8 0.1 0.0015 18.9 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.11 ESA11068.1 - 0.00098 18.2 0.1 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_16 PF10294.4 ESA11068.1 - 0.027 13.9 0.2 0.057 12.8 0.1 1.7 1 1 0 1 1 1 0 Putative methyltransferase FAE1_CUT1_RppA PF08392.7 ESA11068.1 - 0.054 12.5 0.0 0.079 12.0 0.0 1.2 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Methyltransf_23 PF13489.1 ESA11068.1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.1 ESA11068.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Tfb4 PF03850.9 ESA11069.1 - 6.8e-98 327.3 1.3 7.8e-98 327.1 0.9 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Tropomyosin_1 PF12718.2 ESA11070.1 - 2.5e-35 121.4 35.8 2.5e-35 121.4 24.8 1.8 1 1 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 ESA11070.1 - 8.8e-13 47.8 38.9 3.2e-07 29.6 17.6 2.3 1 1 1 2 2 2 2 Tropomyosin CENP-F_leu_zip PF10473.4 ESA11070.1 - 1.7e-05 24.6 40.9 0.00021 21.1 22.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Hsk3 PF08227.6 ESA11070.1 - 0.0018 18.4 1.9 0.011 15.8 0.1 2.7 2 1 0 2 2 2 1 DASH complex subunit Hsk3 like Fib_alpha PF08702.5 ESA11070.1 - 0.01 15.9 20.9 0.047 13.8 3.1 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SH3BP5 PF05276.9 ESA11070.1 - 0.015 14.5 22.8 0.018 14.3 15.8 1.0 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Filament PF00038.16 ESA11070.1 - 0.018 14.4 28.1 0.12 11.8 10.5 2.1 1 1 1 2 2 2 0 Intermediate filament protein Myosin_tail_1 PF01576.14 ESA11070.1 - 0.02 12.6 36.1 0.022 12.5 25.0 1.0 1 0 0 1 1 1 0 Myosin tail IncA PF04156.9 ESA11070.1 - 0.023 14.3 35.2 0.25 10.9 10.1 2.1 1 1 1 2 2 2 0 IncA protein TBPIP PF07106.8 ESA11070.1 - 0.027 14.0 34.2 0.053 13.0 8.7 3.0 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ADIP PF11559.3 ESA11070.1 - 0.058 13.2 31.2 1.8 8.4 11.4 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF1192 PF06698.6 ESA11070.1 - 0.083 12.7 0.5 0.083 12.7 0.3 4.4 3 2 2 5 5 5 0 Protein of unknown function (DUF1192) MAD PF05557.8 ESA11070.1 - 0.092 10.8 34.0 0.12 10.4 23.6 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein AAA_13 PF13166.1 ESA11070.1 - 0.1 11.0 29.7 0.15 10.4 20.6 1.3 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.6 ESA11070.1 - 0.11 11.1 35.3 0.19 10.3 9.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.1 ESA11070.1 - 0.11 12.4 40.3 0.66 9.9 6.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) E2R135 PF11570.3 ESA11070.1 - 0.13 12.3 16.0 0.29 11.2 10.9 1.9 1 1 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF2422 PF10337.4 ESA11070.1 - 0.16 10.7 9.9 0.18 10.5 6.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Reo_sigmaC PF04582.7 ESA11070.1 - 0.25 10.4 8.4 1 8.4 3.7 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein HrpB7 PF09486.5 ESA11070.1 - 0.25 11.2 20.0 0.68 9.8 4.8 3.1 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) Cluap1 PF10234.4 ESA11070.1 - 0.3 10.2 26.2 0.25 10.4 9.8 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 HalX PF08663.5 ESA11070.1 - 0.36 10.8 25.0 4.3 7.3 0.1 4.5 2 1 2 4 4 4 0 HalX domain TPR_MLP1_2 PF07926.7 ESA11070.1 - 0.37 10.5 38.3 0.17 11.6 15.1 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GAS PF13851.1 ESA11070.1 - 0.38 9.9 34.8 3.8 6.6 24.1 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 ESA11070.1 - 0.39 10.4 33.4 0.027 14.1 12.5 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Ax_dynein_light PF10211.4 ESA11070.1 - 0.42 10.4 31.3 2.7 7.8 9.3 2.6 1 1 2 3 3 3 0 Axonemal dynein light chain DUF3584 PF12128.3 ESA11070.1 - 0.51 7.6 29.1 0.56 7.4 20.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.6 ESA11070.1 - 0.57 9.9 30.2 2.2 8.0 5.8 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) WXG100 PF06013.7 ESA11070.1 - 0.6 10.1 10.4 4.2 7.4 0.6 3.9 3 2 1 4 4 4 0 Proteins of 100 residues with WXG Lebercilin PF15619.1 ESA11070.1 - 0.74 9.2 33.5 0.64 9.4 6.9 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3450 PF11932.3 ESA11070.1 - 0.78 8.9 19.6 0.088 12.0 6.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlxA PF14282.1 ESA11070.1 - 0.81 9.6 25.5 0.077 12.9 6.1 3.0 1 1 2 3 3 3 0 FlxA-like protein FliD_C PF07195.7 ESA11070.1 - 0.9 8.7 20.3 0.13 11.5 4.8 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus Rootletin PF15035.1 ESA11070.1 - 0.94 9.4 27.2 0.072 13.0 9.7 2.0 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Seryl_tRNA_N PF02403.17 ESA11070.1 - 0.97 9.4 36.2 1.1 9.2 13.4 3.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cast PF10174.4 ESA11070.1 - 1 7.3 35.0 1.8 6.5 24.2 1.4 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Prefoldin_2 PF01920.15 ESA11070.1 - 1.2 8.9 38.3 2.8 7.7 7.0 4.1 1 1 2 3 3 3 0 Prefoldin subunit BRE1 PF08647.6 ESA11070.1 - 1.3 9.0 32.1 0.15 12.0 4.3 2.9 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Laminin_I PF06008.9 ESA11070.1 - 1.5 8.0 28.4 0.71 9.1 8.6 2.0 1 1 1 2 2 2 0 Laminin Domain I Laminin_II PF06009.7 ESA11070.1 - 1.6 8.4 24.0 0.15 11.8 7.9 2.1 1 1 1 2 2 2 0 Laminin Domain II MogR_DNAbind PF12181.3 ESA11070.1 - 1.7 8.4 13.9 8.4 6.1 7.8 2.8 1 1 1 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) STAT_alpha PF01017.15 ESA11070.1 - 1.8 8.2 19.5 2.4 7.8 6.2 2.7 1 1 1 2 2 2 0 STAT protein, all-alpha domain CALCOCO1 PF07888.6 ESA11070.1 - 2.3 6.4 24.9 0.47 8.6 13.4 1.8 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6 PF04111.7 ESA11070.1 - 2.5 7.0 36.6 1.7 7.6 14.2 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF641 PF04859.7 ESA11070.1 - 2.7 7.7 24.4 3.3 7.4 8.9 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Flagellin_C PF00700.16 ESA11070.1 - 2.7 8.1 10.7 1.2 9.2 1.4 3.1 1 1 3 4 4 4 0 Bacterial flagellin C-terminal helical region DUF1664 PF07889.7 ESA11070.1 - 2.8 7.7 17.9 2 8.2 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 ESA11070.1 - 3.9 7.7 11.6 3.9 7.8 1.9 3.2 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein bZIP_2 PF07716.10 ESA11070.1 - 4 7.3 31.7 0.72 9.7 1.0 4.8 5 0 0 5 5 5 0 Basic region leucine zipper FemAB PF02388.11 ESA11070.1 - 4.4 5.8 24.0 2.6 6.6 7.0 2.1 1 1 1 2 2 2 0 FemAB family Prefoldin PF02996.12 ESA11070.1 - 4.5 6.9 30.2 1 9.0 11.2 2.9 1 1 1 2 2 2 0 Prefoldin subunit Mnd1 PF03962.10 ESA11070.1 - 5.4 6.6 32.7 0.17 11.5 8.2 2.8 1 1 2 3 3 3 0 Mnd1 family Lectin_N PF03954.9 ESA11070.1 - 6.5 6.1 16.0 4.7 6.6 1.6 3.0 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Striatin PF08232.7 ESA11070.1 - 8.3 6.7 27.1 15 5.9 12.9 2.7 1 1 0 2 2 2 0 Striatin family Fmp27_WPPW PF10359.4 ESA11070.1 - 8.4 4.6 26.9 2.2 6.5 7.9 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Uds1 PF15456.1 ESA11070.1 - 8.5 6.3 28.7 15 5.6 13.5 3.4 1 1 1 2 2 2 0 Up-regulated During Septation zf-CCCH PF00642.19 ESA11071.1 - 8.6e-16 57.2 35.6 1.9e-06 27.3 0.3 5.2 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESA11071.1 - 0.044 13.8 34.2 0.19 11.7 1.4 5.7 6 0 0 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type PsaL PF02605.10 ESA11073.1 - 0.022 14.2 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI DUF2207 PF09972.4 ESA11073.1 - 0.023 13.3 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Herpes_gE PF02480.11 ESA11073.1 - 0.035 12.3 0.0 0.038 12.2 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF872 PF05915.7 ESA11073.1 - 0.059 13.2 0.4 0.12 12.2 0.3 1.6 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF912 PF06024.7 ESA11073.1 - 0.13 12.3 0.2 0.35 10.9 0.0 1.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMEM154 PF15102.1 ESA11073.1 - 0.48 10.1 6.7 1.8 8.2 4.4 2.0 1 1 0 1 1 1 0 TMEM154 protein family Hamartin PF04388.7 ESA11073.1 - 1.1 7.8 4.2 1.5 7.3 2.9 1.1 1 0 0 1 1 1 0 Hamartin protein FYVE PF01363.16 ESA11074.1 - 4.3e-19 68.1 12.8 4.3e-19 68.1 8.9 3.2 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 ESA11074.1 - 8.8e-11 41.4 4.5 8.8e-11 41.4 3.1 3.7 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA11074.1 - 0.0002 21.3 4.0 0.0002 21.3 2.8 4.4 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA11074.1 - 0.00053 20.0 1.3 0.00053 20.0 0.9 3.8 2 1 0 2 2 1 1 RING-H2 zinc finger FANCL_C PF11793.3 ESA11074.1 - 0.00058 19.7 2.9 0.00058 19.7 2.0 3.5 3 1 0 3 3 3 1 FANCL C-terminal domain zf-RING_UBOX PF13445.1 ESA11074.1 - 0.0028 17.3 2.6 0.0028 17.3 1.8 3.0 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA11074.1 - 0.003 17.2 28.2 0.17 11.6 3.1 4.0 3 1 0 3 3 3 3 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA11074.1 - 0.028 14.0 3.4 0.028 14.0 2.4 4.6 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Coronavirus_5 PF05528.6 ESA11074.1 - 0.053 13.3 0.5 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Coronavirus gene 5 protein MAP65_ASE1 PF03999.7 ESA11074.1 - 0.71 8.4 3.7 0.9 8.0 2.6 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF2321 PF10083.4 ESA11074.1 - 0.96 8.9 4.8 0.75 9.2 0.1 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C3HC4_4 PF15227.1 ESA11074.1 - 5.2 7.0 22.9 0.84 9.5 2.8 4.5 5 0 0 5 5 5 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 ESA11074.1 - 7.5 6.1 15.4 18 4.9 0.0 4.5 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 DZR PF12773.2 ESA11074.1 - 8.9 6.2 24.1 1.5e+04 -9.1 16.7 4.1 1 1 0 1 1 0 0 Double zinc ribbon Ank_2 PF12796.2 ESA11075.1 - 8.5e-30 102.9 0.0 6.3e-19 68.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESA11075.1 - 1.7e-21 75.7 0.0 8.6e-10 38.5 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 ESA11075.1 - 1.7e-21 74.8 0.0 1.6e-10 40.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 ESA11075.1 - 4.9e-19 66.5 0.2 9.7e-09 34.6 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESA11075.1 - 1.6e-16 60.2 0.0 7.9e-09 35.7 0.0 2.6 2 1 0 2 2 2 2 Ankyrin repeats (many copies) RNase_H PF00075.19 ESA11076.1 - 1.7e-12 47.7 0.2 3.5e-12 46.7 0.1 1.5 1 0 0 1 1 1 1 RNase H TrbI_Ftype PF09677.5 ESA11076.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) Sel1 PF08238.7 ESA11077.1 - 5.3e-109 354.2 46.8 2.3e-13 50.2 0.4 10.9 10 1 1 11 11 11 10 Sel1 repeat TPR_6 PF13174.1 ESA11077.1 - 1.3e-11 44.1 21.7 0.58 10.7 0.0 9.6 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11077.1 - 1.2e-06 28.1 25.8 1.8 8.9 0.1 10.8 10 2 0 10 10 10 1 Tetratricopeptide repeat MIT PF04212.13 ESA11077.1 - 1.1e-05 25.1 32.6 0.95 9.3 0.1 8.3 7 2 1 8 8 8 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA11077.1 - 0.00013 21.6 4.5 30 4.4 0.0 6.6 7 0 0 7 7 7 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA11077.1 - 0.00015 21.8 6.9 0.3 11.2 0.0 5.3 1 1 5 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA11077.1 - 0.0023 18.5 3.5 21 5.9 0.0 5.1 3 2 2 5 5 5 0 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA11077.1 - 0.0037 16.9 0.0 7.4 6.1 0.0 4.4 2 1 1 3 3 3 1 Caspase domain Foie-gras_1 PF11817.3 ESA11077.1 - 0.041 13.3 10.7 1.2 8.5 0.1 4.0 2 2 1 3 3 3 0 Foie gras liver health family 1 HTH_16 PF12645.2 ESA11077.1 - 0.23 11.3 11.3 15 5.5 0.1 5.7 5 1 1 6 6 6 0 Helix-turn-helix domain LIM_bind PF01803.11 ESA11077.1 - 0.27 10.3 6.1 13 4.8 0.2 3.1 2 1 0 3 3 3 0 LIM-domain binding protein SPC22 PF04573.7 ESA11079.1 - 1.5e-42 144.7 3.3 1.8e-42 144.5 2.3 1.0 1 0 0 1 1 1 1 Signal peptidase subunit UPF0203 PF05254.7 ESA11080.1 - 1.4e-26 92.0 4.7 1.7e-26 91.8 3.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) CHCH PF06747.8 ESA11080.1 - 0.00033 20.4 3.0 0.17 11.8 0.1 2.4 2 0 0 2 2 2 2 CHCH domain Cmc1 PF08583.5 ESA11080.1 - 0.0027 17.4 6.6 0.25 11.1 0.4 2.4 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.8 ESA11080.1 - 0.03 14.3 2.2 0.063 13.3 1.5 1.5 1 1 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) UCR_hinge PF02320.11 ESA11080.1 - 0.2 11.6 4.2 0.73 9.8 2.9 1.8 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein Pet191_N PF10203.4 ESA11080.1 - 0.24 11.4 3.6 6.5 6.8 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.12 ESA11080.1 - 1.3 9.1 7.2 5.1 7.2 1.3 1.9 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb Octopine_DH PF02317.12 ESA11081.1 - 0.042 13.5 1.4 0.7 9.5 0.1 2.1 1 1 1 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain PIF1 PF05970.9 ESA11082.1 - 0.12 11.3 0.2 0.26 10.2 0.1 1.6 1 1 0 1 1 1 0 PIF1-like helicase bZIP_1 PF00170.16 ESA11084.1 - 4.3e-12 45.8 12.6 1.1e-11 44.4 8.7 1.7 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ESA11084.1 - 1.6e-10 40.6 10.5 1.6e-10 40.6 7.3 1.8 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 ESA11084.1 - 6.6e-06 26.3 8.1 6.6e-06 26.3 5.6 1.7 1 1 0 2 2 2 1 bZIP Maf transcription factor Plant_all_beta PF10532.4 ESA11084.1 - 0.025 14.6 1.1 0.025 14.6 0.8 1.6 2 0 0 2 2 2 0 Plant specific N-all beta domain Striatin PF08232.7 ESA11084.1 - 0.03 14.6 6.0 0.03 14.6 4.2 2.7 1 1 2 3 3 3 0 Striatin family GAS PF13851.1 ESA11084.1 - 0.038 13.1 10.8 0.049 12.8 7.5 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Peptidase_S55 PF05580.7 ESA11084.1 - 0.12 11.8 0.7 0.14 11.5 0.5 1.2 1 0 0 1 1 1 0 SpoIVB peptidase S55 DivIC PF04977.10 ESA11084.1 - 0.41 10.1 6.6 2.3 7.7 2.6 2.4 2 0 0 2 2 2 0 Septum formation initiator APG6 PF04111.7 ESA11084.1 - 0.44 9.5 10.1 0.58 9.1 7.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 ESA11084.1 - 0.49 9.9 10.6 1 8.9 7.4 1.5 1 1 0 1 1 1 0 IncA protein DUF724 PF05266.9 ESA11084.1 - 8.6 5.9 12.0 7.2 6.1 7.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF4218 PF13960.1 ESA11086.1 - 0.00017 20.9 0.1 0.00041 19.7 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Stap_Strp_toxin PF01123.15 ESA11086.1 - 1.3 9.5 6.5 0.31 11.5 0.4 2.4 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain Imm1 PF14430.1 ESA11087.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 Immunity protein Imm1 F-box-like PF12937.2 ESA11089.1 - 0.0026 17.4 0.0 0.0072 16.0 0.0 1.7 1 0 0 1 1 1 1 F-box-like YxiJ PF14176.1 ESA11089.1 - 0.5 10.4 6.4 0.19 11.8 2.2 1.9 1 1 0 2 2 2 0 YxiJ-like protein Myb_DNA-bind_6 PF13921.1 ESA11091.1 - 7e-05 22.8 0.8 7e-05 22.8 0.5 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA11091.1 - 0.00012 22.1 2.8 0.047 13.7 0.6 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Retrotrans_gag PF03732.12 ESA11091.1 - 0.1 12.6 4.3 0.041 13.9 1.0 2.0 2 1 0 2 2 2 0 Retrotransposon gag protein Myb_DNA-bind_3 PF12776.2 ESA11091.1 - 0.17 12.5 10.0 0.24 12.0 0.8 2.6 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Dimer_Tnp_hAT PF05699.9 ESA11093.1 - 5e-07 29.2 0.1 1.3e-06 27.9 0.1 1.8 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Cwf_Cwc_15 PF04889.7 ESA11093.1 - 0.033 13.9 8.2 0.07 12.8 5.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Surface_antigen PF11054.3 ESA11093.1 - 0.043 13.2 0.3 0.08 12.3 0.2 1.4 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen DUF1032 PF06278.6 ESA11093.1 - 0.055 11.9 4.6 0.074 11.5 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1032) DUF2457 PF10446.4 ESA11093.1 - 0.16 10.6 15.1 0.2 10.3 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 ESA11093.1 - 0.48 8.8 11.3 0.58 8.5 7.8 1.1 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 ESA11093.1 - 5.1 6.2 11.9 6.9 5.8 8.2 1.3 1 0 0 1 1 1 0 SDA1 ETX_MTX2 PF03318.8 ESA11094.1 - 0.00066 19.2 0.4 0.00066 19.2 0.3 2.4 2 1 1 3 3 3 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 LMBR1 PF04791.11 ESA11096.1 - 4.7e-36 124.3 16.7 6.4e-36 123.9 11.6 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF2630 PF10944.3 ESA11096.1 - 0.15 12.1 0.8 7.4 6.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) DUF999 PF06198.6 ESA11097.1 - 1.2 8.8 4.0 1.5 8.6 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF999) DDE_1 PF03184.14 ESA11098.1 - 3.1e-48 163.8 2.0 3.9e-48 163.4 1.4 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA11098.1 - 0.0016 18.1 0.1 0.0027 17.4 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease CENP-B_N PF04218.8 ESA11098.1 - 0.0035 16.7 0.0 0.01 15.2 0.0 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain NSP13 PF06460.7 ESA11098.1 - 0.01 14.7 0.2 0.015 14.2 0.1 1.2 1 0 0 1 1 1 0 Coronavirus NSP13 HTH_3 PF01381.17 ESA11098.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix mRNA_cap_enzyme PF01331.14 ESA11100.1 - 0.026 14.2 7.7 0.03 14.0 5.3 1.1 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain Myb_DNA-bind_6 PF13921.1 ESA11100.1 - 0.033 14.2 5.3 0.047 13.8 0.7 2.3 1 1 1 2 2 2 0 Myb-like DNA-binding domain DUF3800 PF12686.2 ESA11100.1 - 0.13 11.8 4.0 0.16 11.6 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) Rtt106 PF08512.7 ESA11102.1 - 0.31 11.0 2.5 0.62 10.0 1.3 1.9 2 0 0 2 2 2 0 Histone chaperone Rttp106-like DsbD PF02683.10 ESA11105.1 - 0.38 10.3 3.7 1.3 8.5 0.5 1.9 1 1 1 2 2 2 0 Cytochrome C biogenesis protein transmembrane region JAB PF01398.16 ESA11108.1 - 0.00012 21.7 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HABP4_PAI-RBP1 PF04774.10 ESA11109.1 - 0.015 15.8 9.0 0.015 15.8 6.3 5.5 3 3 3 6 6 6 0 Hyaluronan / mRNA binding family TMEM51 PF15345.1 ESA11109.1 - 0.45 10.1 3.8 0.99 9.0 2.6 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 MitMem_reg PF13012.1 ESA11110.1 - 1.3e-40 138.0 4.2 1.4e-40 137.9 1.8 1.9 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 ESA11110.1 - 8e-31 106.1 0.0 1.7e-30 105.0 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Clat_adaptor_s PF01217.15 ESA11110.1 - 0.03 14.0 0.2 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Clathrin adaptor complex small chain Latarcin PF10279.4 ESA11110.1 - 0.1 12.8 0.1 0.1 12.8 0.0 2.4 3 0 0 3 3 3 0 Latarcin precursor adh_short PF00106.20 ESA11111.1 - 0.00012 22.0 0.0 0.0015 18.4 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 ESA11111.1 - 0.0022 17.4 0.0 0.037 13.4 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 ESA11111.1 - 0.0071 16.1 0.0 0.0083 15.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Semialdhyde_dh PF01118.19 ESA11111.1 - 0.022 15.0 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.12 ESA11111.1 - 0.044 12.6 0.0 0.061 12.2 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.8 ESA11111.1 - 0.064 12.4 0.0 0.08 12.1 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.1 ESA11111.1 - 0.084 12.8 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding bZIP_1 PF00170.16 ESA11112.1 - 7.2e-12 45.0 10.0 1.2e-11 44.3 6.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ESA11112.1 - 1e-06 28.4 10.6 1.8e-06 27.6 7.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper Aft1_OSA PF11785.3 ESA11112.1 - 1.7e-06 28.4 2.9 9.8e-06 26.0 2.0 2.3 1 0 0 1 1 1 1 Aft1 osmotic stress response (OSM) domain Aft1_HRA PF11786.3 ESA11112.1 - 7.1e-06 26.1 5.9 0.0015 18.7 4.1 3.2 1 1 0 1 1 1 1 Aft1 HRA domain bZIP_Maf PF03131.12 ESA11112.1 - 0.0051 17.0 7.0 0.0096 16.1 4.9 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.13 ESA11112.1 - 0.017 14.8 2.8 0.028 14.1 2.0 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper Macoilin PF09726.4 ESA11112.1 - 1.3 7.2 11.9 1.9 6.6 8.2 1.2 1 0 0 1 1 1 0 Transmembrane protein ELMO_CED12 PF04727.8 ESA11113.1 - 3.9e-08 33.0 0.4 1.8e-07 30.8 0.3 1.8 1 1 0 1 1 1 1 ELMO/CED-12 family DDE_1 PF03184.14 ESA11114.1 - 4.7e-40 137.0 2.8 6e-40 136.7 1.5 1.5 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA11114.1 - 8.8e-10 38.2 0.3 1.9e-09 37.1 0.2 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA11114.1 - 3.1e-09 36.1 0.7 8.8e-09 34.6 0.5 1.9 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_3 PF13358.1 ESA11114.1 - 0.00017 21.3 0.2 0.0003 20.5 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.1 ESA11114.1 - 0.02 14.4 0.0 0.39 10.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease Dimer_Tnp_hAT PF05699.9 ESA11115.1 - 0.00014 21.3 0.0 0.00035 20.1 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2393 PF09624.5 ESA11118.1 - 0.12 11.8 0.2 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) DUF1637 PF07847.7 ESA11119.1 - 0.14 11.4 2.7 3.6 6.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1637) Suppressor_P21 PF11479.3 ESA11120.1 - 0.019 14.7 1.5 0.045 13.5 0.2 2.0 2 0 0 2 2 2 0 RNA silencing suppressor P21 DUF787 PF05619.6 ESA11122.1 - 0.075 11.6 0.0 0.087 11.4 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) Sel1 PF08238.7 ESA11124.1 - 2.5e-55 183.6 32.9 7.3e-13 48.6 0.3 8.6 9 0 0 9 9 9 7 Sel1 repeat TPR_6 PF13174.1 ESA11124.1 - 0.00024 21.3 7.7 13 6.5 0.0 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat PHB_acc_N PF07879.6 ESA11124.1 - 0.021 14.5 0.0 4.7 7.0 0.1 2.3 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain TPR_11 PF13414.1 ESA11124.1 - 0.03 13.9 10.0 0.31 10.6 1.4 4.8 3 2 2 5 5 5 0 TPR repeat MIT PF04212.13 ESA11124.1 - 0.26 11.1 9.5 8.1 6.4 0.5 4.9 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain DUF1351 PF07083.6 ESA11125.1 - 0.0013 18.4 1.5 0.0019 17.8 1.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1351) Med11 PF10280.4 ESA11125.1 - 0.035 14.1 0.1 0.039 14.0 0.1 1.1 1 0 0 1 1 1 0 Mediator complex protein DUF904 PF06005.7 ESA11125.1 - 0.18 12.0 1.5 0.8 10.0 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Pkinase_Tyr PF07714.12 ESA11126.1 - 4.8e-29 101.2 0.0 5.8e-29 100.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11126.1 - 9.1e-29 100.3 0.1 1e-28 100.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA11126.1 - 0.0015 17.6 0.1 0.0018 17.3 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA11126.1 - 0.0015 17.5 0.0 0.0018 17.3 0.0 1.0 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA11126.1 - 0.014 14.7 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL WaaY PF06176.6 ESA11126.1 - 0.018 14.2 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA11126.1 - 0.04 13.2 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ESA11126.1 - 0.075 12.7 0.1 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA11127.1 - 2.2e-106 345.9 36.6 1.2e-11 44.8 0.4 11.0 11 0 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ESA11127.1 - 1.2e-10 41.1 21.7 0.45 11.0 0.1 9.0 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA11127.1 - 0.0055 17.0 16.2 6.4 7.1 0.0 6.2 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA11127.1 - 0.0077 15.8 35.0 0.29 10.8 1.8 7.0 3 2 4 8 8 8 3 TPR repeat TPR_16 PF13432.1 ESA11127.1 - 0.0098 16.5 9.9 18 6.1 0.1 6.1 3 3 3 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA11127.1 - 0.048 12.7 0.3 0.25 10.3 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat CoA_binding_3 PF13727.1 ESA11129.1 - 6 6.6 9.2 2.6 7.8 4.7 1.6 2 0 0 2 2 2 0 CoA-binding domain FAST_1 PF06743.10 ESA11130.1 - 0.099 12.3 0.2 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 DUF1762 PF08574.5 ESA11132.1 - 0.75 10.2 0.1 0.75 10.2 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1762) Pkinase_Tyr PF07714.12 ESA11135.1 - 2.9e-25 88.8 0.0 3.2e-25 88.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11135.1 - 2.3e-21 76.1 0.0 2.7e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA11135.1 - 0.015 14.2 0.0 0.021 13.8 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Bac_DnaA PF00308.13 ESA11136.1 - 0.00053 19.6 0.1 0.0062 16.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial dnaA protein RNA_helicase PF00910.17 ESA11136.1 - 0.015 15.4 0.3 0.24 11.5 0.0 3.2 3 0 0 3 3 3 0 RNA helicase AAA_22 PF13401.1 ESA11136.1 - 0.018 15.1 0.1 0.089 12.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA11136.1 - 0.048 13.6 0.0 0.089 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain DnaJ PF00226.26 ESA11137.1 - 5.4e-20 70.8 0.5 1.3e-19 69.6 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 ESA11137.1 - 4.5e-16 58.7 2.3 6.3e-08 32.1 0.1 2.5 3 0 0 3 3 3 2 X-domain of DnaJ-containing GvpG PF05120.7 ESA11137.1 - 0.0018 18.0 0.1 0.0082 15.9 0.1 2.1 2 0 0 2 2 2 1 Gas vesicle protein G EF-hand_5 PF13202.1 ESA11137.1 - 0.016 14.5 0.1 1.3 8.5 0.0 2.8 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.27 ESA11137.1 - 0.017 14.4 0.1 1.7 8.1 0.0 2.9 2 0 0 2 2 2 0 EF hand DMAP_binding PF06464.6 ESA11137.1 - 0.02 15.4 0.4 0.056 14.0 0.3 1.7 1 0 0 1 1 1 0 DMAP1-binding Domain DnaJ PF00226.26 ESA11138.1 - 1.1e-21 76.2 0.9 1.3e-21 76.0 0.6 1.0 1 0 0 1 1 1 1 DnaJ domain MCLC PF05934.6 ESA11139.1 - 0.26 9.5 2.9 0.29 9.3 2.0 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DUF2626 PF11117.3 ESA11139.1 - 0.53 10.7 9.1 1.5 9.3 2.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2626) DMAP_binding PF06464.6 ESA11140.1 - 0.097 13.2 0.5 0.1 13.1 0.4 1.1 1 0 0 1 1 1 0 DMAP1-binding Domain DSS1_SEM1 PF05160.8 ESA11140.1 - 0.13 12.1 5.2 0.17 11.7 3.6 1.2 1 0 0 1 1 1 0 DSS1/SEM1 family CENP-F_leu_zip PF10473.4 ESA11141.1 - 0.0099 15.7 16.9 0.0099 15.7 11.7 5.5 1 1 4 6 6 6 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 ESA11141.1 - 5.9 5.9 14.7 0.56 9.3 4.6 2.4 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Pkinase PF00069.20 ESA11143.1 - 1.2e-34 119.6 0.1 2.3e-34 118.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11143.1 - 6.3e-34 117.2 0.0 9e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4127 PF13552.1 ESA11143.1 - 0.014 13.8 1.4 0.021 13.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) Kdo PF06293.9 ESA11143.1 - 0.039 13.0 0.1 0.08 12.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3087 PF11286.3 ESA11143.1 - 0.12 11.6 0.1 0.12 11.6 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3087) APH PF01636.18 ESA11143.1 - 0.15 11.7 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_11 PF13086.1 ESA11145.1 - 4.1e-07 29.8 0.1 6.3e-06 25.9 0.0 2.2 1 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 ESA11145.1 - 0.00013 21.5 0.0 0.00029 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA11145.1 - 0.00071 19.2 0.0 0.0022 17.6 0.0 1.8 1 1 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESA11145.1 - 0.0056 16.8 0.0 0.017 15.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 ESA11145.1 - 0.0083 15.3 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DEAD PF00270.24 ESA11145.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase T2SE PF00437.15 ESA11145.1 - 0.024 13.5 0.0 0.56 9.0 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF4214 PF13946.1 ESA11145.1 - 0.04 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) DUF4631 PF15450.1 ESA11145.1 - 0.046 12.0 0.5 0.076 11.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4631) Ribosomal_L29e PF01779.12 ESA11145.1 - 0.073 12.9 0.6 0.2 11.5 0.4 1.8 1 0 0 1 1 1 0 Ribosomal L29e protein family AAA_16 PF13191.1 ESA11145.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 ESA11145.1 - 0.15 12.8 2.8 4.2 8.2 0.2 3.1 1 1 1 2 2 2 0 AAA domain RICH PF05062.7 ESA11145.1 - 2 8.6 6.9 2.1 8.5 1.0 2.8 2 0 0 2 2 2 0 RICH domain AAA_11 PF13086.1 ESA11146.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain Ribosomal_L29e PF01779.12 ESA11146.1 - 0.018 14.8 0.6 0.036 13.9 0.4 1.4 1 0 0 1 1 1 0 Ribosomal L29e protein family WAC_Acf1_DNA_bd PF10537.4 ESA11147.1 - 0.062 13.4 0.9 0.092 12.9 0.6 1.3 1 0 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal APG12 PF04110.8 ESA11149.1 - 0.08 13.1 0.2 0.4 10.9 0.0 2.3 3 0 0 3 3 3 0 Ubiquitin-like autophagy protein Apg12 PCRF PF03462.13 ESA11150.1 - 8.9e-33 112.4 0.6 8.9e-33 112.4 0.4 2.2 2 1 1 3 3 3 1 PCRF domain RF-1 PF00472.15 ESA11150.1 - 4.3e-22 78.0 1.2 4.9e-22 77.8 0.1 1.7 2 0 0 2 2 2 1 RF-1 domain YbjQ_1 PF01906.12 ESA11150.1 - 0.05 14.0 0.1 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative heavy-metal-binding SecA_SW PF07516.8 ESA11150.1 - 0.057 13.1 5.0 0.093 12.4 3.5 1.3 1 0 0 1 1 1 0 SecA Wing and Scaffold domain IF-2B PF01008.12 ESA11150.1 - 0.062 12.2 0.5 0.084 11.8 0.3 1.1 1 0 0 1 1 1 0 Initiation factor 2 subunit family TRI5 PF06330.6 ESA11150.1 - 0.1 11.2 0.0 0.18 10.4 0.0 1.3 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) DUF4422 PF14393.1 ESA11150.1 - 0.18 11.3 2.3 1.7 8.1 1.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4422) Mcm10 PF09332.6 ESA11150.1 - 0.26 10.6 3.1 0.35 10.1 2.1 1.2 1 0 0 1 1 1 0 Mcm10 replication factor DUF334 PF03904.8 ESA11150.1 - 0.65 9.2 5.2 0.98 8.6 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF947 PF06102.7 ESA11150.1 - 1.3 8.7 5.7 1.5 8.6 3.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF947) PAXNEB PF05625.6 ESA11151.1 - 3.4e-77 259.7 0.7 4.1e-77 259.4 0.5 1.0 1 0 0 1 1 1 1 PAXNEB protein FolB PF02152.13 ESA11151.1 - 0.045 13.9 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 Dihydroneopterin aldolase HMG_box PF00505.14 ESA11152.1 - 2.6e-05 24.3 0.4 4.2e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box Sel1 PF08238.7 ESA11153.1 - 6.6e-131 423.9 63.8 6.1e-10 39.4 0.1 16.0 16 0 0 16 16 16 16 Sel1 repeat TPR_6 PF13174.1 ESA11153.1 - 2.2e-07 30.9 20.6 1.8 9.2 0.0 9.5 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA11153.1 - 0.023 15.3 7.7 78 4.1 0.0 6.3 6 1 1 7 7 7 0 Tetratricopeptide repeat WD40 PF00400.27 ESA11154.1 - 4e-47 156.4 6.5 2.6e-12 46.0 0.0 7.5 8 0 0 8 8 8 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA11154.1 - 0.072 12.8 0.1 0.8 9.3 0.0 2.2 1 1 2 3 3 3 0 Eukaryotic translation initiation factor eIF2A bZIP_1 PF00170.16 ESA11154.1 - 0.079 12.9 1.8 0.15 12.0 1.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor AIRC PF00731.15 ESA11155.1 - 8.7e-62 206.8 1.2 1.3e-61 206.2 0.4 1.6 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.17 ESA11155.1 - 2.7e-60 202.6 0.0 4.3e-60 201.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 ESA11155.1 - 1.3e-11 44.5 0.0 2.9e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESA11155.1 - 1.4e-09 37.6 0.1 4.5e-09 35.9 0.1 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 ESA11155.1 - 5.8e-06 25.2 0.0 0.0048 15.6 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.6 ESA11155.1 - 7.9e-05 22.2 0.1 0.0002 20.8 0.1 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain XdhC_C PF13478.1 ESA11155.1 - 0.002 18.4 0.0 0.0092 16.2 0.0 2.1 2 0 0 2 2 2 1 XdhC Rossmann domain NAD_binding_10 PF13460.1 ESA11155.1 - 0.002 18.1 0.1 0.0048 16.9 0.0 1.7 1 0 0 1 1 1 1 NADH(P)-binding ATP-grasp_3 PF02655.9 ESA11155.1 - 0.0082 16.0 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain NmrA PF05368.8 ESA11155.1 - 0.0099 15.1 0.1 0.03 13.5 0.0 1.8 1 0 0 1 1 1 1 NmrA-like family 2-Hacid_dh_C PF02826.14 ESA11155.1 - 0.017 14.2 0.0 0.038 13.1 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 ESA11155.1 - 0.096 13.1 0.4 0.36 11.2 0.1 2.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF1232 PF06803.7 ESA11156.1 - 0.095 12.1 1.6 0.16 11.4 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1232) LRR_6 PF13516.1 ESA11156.1 - 0.11 12.6 0.4 9 6.7 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat Folliculin PF11704.3 ESA11157.1 - 2.7e-38 131.1 0.0 4.2e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Chromo_shadow PF01393.14 ESA11158.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Chromo shadow domain Pkinase_Tyr PF07714.12 ESA11159.1 - 1.9e-11 43.5 0.0 3.1e-11 42.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11159.1 - 1.7e-10 40.4 0.0 2.5e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Laminin_EGF PF00053.19 ESA11159.1 - 0.0085 16.0 1.3 0.014 15.2 0.5 1.6 2 0 0 2 2 2 1 Laminin EGF-like (Domains III and V) AAA_12 PF13087.1 ESA11160.1 - 7.6e-19 67.8 0.1 9.6e-19 67.5 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA11160.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain NYN PF01936.13 ESA11160.1 - 0.038 14.2 0.0 0.054 13.7 0.0 1.1 1 0 0 1 1 1 0 NYN domain AAA_12 PF13087.1 ESA11161.1 - 1.6e-17 63.5 0.1 2.2e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Vanabin-2 PF11437.3 ESA11161.1 - 0.12 12.3 27.8 0.12 12.4 18.5 1.6 1 1 0 1 1 1 0 Vanadium-binding protein 2 AAA_12 PF13087.1 ESA11162.1 - 2.5e-22 79.2 0.2 3.8e-10 39.4 0.0 2.1 1 1 1 2 2 2 2 AAA domain Sel1 PF08238.7 ESA11164.1 - 1.7e-152 492.5 75.5 1.5e-09 38.1 0.0 22.6 22 1 1 23 23 23 20 Sel1 repeat TPR_20 PF14561.1 ESA11164.1 - 0.078 13.0 12.2 34 4.6 0.0 6.7 5 2 0 6 6 6 0 Tetratricopeptide repeat Hemagglutinin PF00509.13 ESA11165.1 - 0.016 13.3 0.2 0.017 13.2 0.1 1.0 1 0 0 1 1 1 0 Haemagglutinin FlaC_arch PF05377.6 ESA11165.1 - 0.016 15.0 0.2 0.053 13.4 0.1 1.8 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1319 PF07028.6 ESA11165.1 - 0.055 13.6 0.0 0.06 13.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Baculo_PEP_C PF04513.7 ESA11165.1 - 0.08 12.7 0.2 0.083 12.7 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Abi_C PF14355.1 ESA11165.1 - 0.11 12.4 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 Abortive infection C-terminus MtrG PF04210.8 ESA11165.1 - 0.12 12.0 0.1 1.6 8.4 0.0 2.0 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Bet_v_1 PF00407.14 ESA11166.1 - 0.011 15.3 0.1 0.013 15.1 0.0 1.2 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family Membrane_bind PF14564.1 ESA11166.1 - 0.053 13.7 1.1 0.069 13.3 0.8 1.3 1 1 0 1 1 1 0 Membrane binding DUF2963 PF11178.3 ESA11166.1 - 0.41 10.1 11.2 0.37 10.2 6.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2963) Glyco_transf_20 PF00982.16 ESA11169.1 - 3.3e-174 579.8 0.1 4.1e-174 579.5 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.1 ESA11169.1 - 0.0012 18.9 0.0 0.0026 17.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Exo_endo_phos PF03372.18 ESA11170.1 - 0.00014 21.9 0.2 0.0015 18.5 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Sel1 PF08238.7 ESA11174.1 - 1.3e-66 219.5 42.3 2.6e-11 43.7 2.3 9.2 9 0 0 9 9 9 9 Sel1 repeat TPR_16 PF13432.1 ESA11174.1 - 0.0089 16.6 4.1 7.8 7.3 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA11174.1 - 0.0099 16.2 18.8 2.5 8.7 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat RPA_C PF08784.6 ESA11174.1 - 0.037 14.4 0.3 0.099 13.0 0.2 1.8 1 0 0 1 1 1 0 Replication protein A C terminal Pkinase_Tyr PF07714.12 ESA11175.1 - 1e-28 100.1 0.0 1.1e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11175.1 - 4.4e-28 98.1 0.1 4.7e-28 98.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA11175.1 - 2.6e-05 23.3 0.2 3.5e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA11175.1 - 0.0005 19.1 0.0 0.0006 18.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA11175.1 - 0.0018 17.6 0.2 0.0023 17.3 0.1 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA11175.1 - 0.0046 16.7 0.1 0.0054 16.4 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA11175.1 - 0.051 12.7 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA11175.1 - 0.055 12.8 0.1 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RRM_1 PF00076.17 ESA11177.1 - 7e-16 57.6 0.2 1.8e-12 46.7 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA11177.1 - 2.8e-07 30.4 0.1 2.3e-06 27.5 0.0 2.4 3 0 0 3 3 3 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA11177.1 - 0.053 13.3 0.1 0.54 10.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEADboxA PF12343.3 ESA11177.1 - 0.23 11.7 9.0 82 3.5 6.3 2.6 1 1 0 1 1 1 0 Cold shock protein DEAD box A Dimer_Tnp_hAT PF05699.9 ESA11180.1 - 5.8e-17 61.1 0.2 6.9e-17 60.8 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3854 PF12965.2 ESA11182.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) Hormone_1 PF00103.15 ESA11182.1 - 0.037 13.3 0.5 0.042 13.1 0.3 1.0 1 0 0 1 1 1 0 Somatotropin hormone family FKS1_dom1 PF14288.1 ESA11182.1 - 0.13 12.2 0.5 0.14 12.0 0.3 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 SWIRM PF04433.12 ESA11185.1 - 8.4e-09 35.4 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 SWIRM domain Sel1 PF08238.7 ESA11186.1 - 1.2e-36 124.3 12.5 9.7e-09 35.5 0.1 6.3 6 1 0 6 6 6 6 Sel1 repeat HTH_38 PF13936.1 ESA11190.1 - 0.013 15.0 0.0 0.029 13.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.1 ESA11190.1 - 0.039 14.1 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.1 ESA11190.1 - 0.041 13.5 0.0 0.098 12.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_27 PF13463.1 ESA11190.1 - 0.047 14.0 0.1 2.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Winged helix DNA-binding domain Ras PF00071.17 ESA11191.1 - 2.7e-56 189.4 0.0 3.2e-56 189.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA11191.1 - 5.8e-17 62.2 0.0 7.7e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA11191.1 - 4.6e-10 39.0 0.0 6e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA11191.1 - 0.00043 19.4 0.0 0.00048 19.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region VirE PF05272.6 ESA11191.1 - 0.0014 18.1 0.0 0.026 13.9 0.0 2.0 1 1 0 2 2 2 1 Virulence-associated protein E MMR_HSR1 PF01926.18 ESA11191.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESA11191.1 - 0.01 15.0 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF4372 PF14294.1 ESA11191.1 - 0.039 13.8 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4372) ABC_tran PF00005.22 ESA11191.1 - 0.084 13.1 0.0 0.12 12.6 0.0 1.6 1 1 0 1 1 1 0 ABC transporter YaeQ PF07152.7 ESA11191.1 - 0.12 11.7 0.1 0.26 10.5 0.1 1.5 1 1 0 1 1 1 0 YaeQ protein WLM PF08325.5 ESA11192.1 - 1.7e-47 161.7 0.1 2.7e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 WLM domain ubiquitin PF00240.18 ESA11192.1 - 7.7e-06 25.2 0.0 1.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Peptidase_MA_2 PF13485.1 ESA11192.1 - 0.011 15.7 0.2 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 Peptidase MA superfamily Ubiquitin_2 PF14560.1 ESA11192.1 - 0.014 15.6 0.2 0.089 13.0 0.0 2.2 1 1 0 2 2 2 0 Ubiquitin-like domain DUF45 PF01863.12 ESA11192.1 - 0.47 10.2 7.2 0.23 11.2 1.0 2.5 2 1 1 3 3 3 0 Protein of unknown function DUF45 FTR1 PF03239.9 ESA11193.1 - 1.8e-61 207.7 10.8 7.2e-59 199.2 7.5 2.0 1 1 0 1 1 1 1 Iron permease FTR1 family 7tm_1 PF00001.16 ESA11193.1 - 0.00025 20.2 0.8 0.021 13.9 0.1 2.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) DUF3169 PF11368.3 ESA11193.1 - 0.0072 15.5 7.9 0.26 10.4 0.1 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3169) Cation_efflux PF01545.16 ESA11193.1 - 0.0077 15.3 0.4 0.46 9.5 0.0 2.4 1 1 1 2 2 2 1 Cation efflux family EphA2_TM PF14575.1 ESA11193.1 - 0.012 16.0 0.9 0.83 10.0 0.0 3.4 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DUF2207 PF09972.4 ESA11193.1 - 0.019 13.5 6.7 0.032 12.8 0.3 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) TMEM154 PF15102.1 ESA11193.1 - 0.029 14.0 0.1 10 5.8 0.0 2.6 2 0 0 2 2 2 0 TMEM154 protein family DUF2615 PF11027.3 ESA11193.1 - 0.03 14.2 0.4 1.5 8.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) COX14 PF14880.1 ESA11193.1 - 0.055 13.1 0.5 5.8 6.6 0.0 3.0 3 0 0 3 3 3 0 Cytochrome oxidase c assembly 60KD_IMP PF02096.15 ESA11193.1 - 0.056 13.1 4.8 1.5 8.4 3.3 2.5 1 1 0 1 1 1 0 60Kd inner membrane protein DUF4381 PF14316.1 ESA11193.1 - 0.059 13.4 0.9 13 5.9 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4381) BatD PF13584.1 ESA11193.1 - 0.083 11.4 0.6 0.14 10.7 0.0 1.6 2 0 0 2 2 2 0 Oxygen tolerance DUF1469 PF07332.6 ESA11193.1 - 0.093 12.4 6.7 2.1 8.1 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1469) PspB PF06667.7 ESA11193.1 - 0.13 12.2 4.0 3.2 7.7 0.0 3.1 3 0 0 3 3 3 0 Phage shock protein B DUF4131 PF13567.1 ESA11193.1 - 0.18 11.2 7.7 2 7.7 1.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF4131) Syndecan PF01034.15 ESA11193.1 - 0.18 11.4 0.0 0.18 11.4 0.0 3.4 5 0 0 5 5 5 0 Syndecan domain YajC PF02699.10 ESA11193.1 - 0.62 9.7 0.0 0.62 9.7 0.0 3.1 4 0 0 4 4 2 0 Preprotein translocase subunit PrgI PF12666.2 ESA11193.1 - 1.5 9.0 12.0 5.8 7.1 0.0 3.7 4 0 0 4 4 3 0 PrgI family protein DUF2500 PF10694.4 ESA11193.1 - 1.7 8.6 4.0 2.5 8.1 0.0 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF2500) ETRAMP PF09716.5 ESA11193.1 - 2.2 8.3 8.7 19 5.3 0.1 4.8 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) DUF2721 PF11026.3 ESA11193.1 - 5.5 6.6 8.7 1.8 8.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Sel1 PF08238.7 ESA11194.1 - 1.9e-138 447.8 70.2 1.2e-09 38.5 0.1 17.2 17 0 0 17 17 17 17 Sel1 repeat TPR_6 PF13174.1 ESA11194.1 - 4.8e-07 29.8 24.4 4.3 8.0 0.0 10.0 11 0 0 11 11 11 5 Tetratricopeptide repeat Sel1 PF08238.7 ESA11195.1 - 6.3e-143 462.1 60.1 2.2e-10 40.8 0.7 19.1 19 0 0 19 19 19 18 Sel1 repeat TPR_6 PF13174.1 ESA11195.1 - 0.0054 17.1 42.0 8.6 7.0 0.1 13.1 16 0 0 16 16 16 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA11195.1 - 0.24 12.1 3.3 18 6.2 0.0 5.2 7 0 0 7 7 7 0 Tetratricopeptide repeat RQC PF09382.5 ESA11195.1 - 0.47 10.1 4.3 1.4 8.6 0.0 3.8 3 1 1 5 5 5 0 RQC domain DUF544 PF04424.8 ESA11195.1 - 1.4 8.7 9.0 39 4.0 0.0 4.9 4 2 0 4 4 4 0 Protein of unknown function (DUF544) TPR_20 PF14561.1 ESA11195.1 - 5.4 7.2 17.4 27 4.9 0.2 6.6 6 3 1 7 7 7 0 Tetratricopeptide repeat Helicase_C PF00271.26 ESA11197.1 - 5.1e-09 35.8 0.0 7.9e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain BcrAD_BadFG PF01869.15 ESA11198.1 - 0.031 13.5 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Helicase_C PF00271.26 ESA11199.1 - 7.9e-10 38.4 0.2 2.3e-08 33.7 0.0 3.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA11199.1 - 3e-07 30.0 0.5 6.7e-06 25.6 0.3 2.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA11199.1 - 0.0081 16.0 0.1 0.027 14.3 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESA11200.1 - 0.053 13.2 0.0 0.078 12.7 0.0 1.2 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 ESA11200.1 - 0.11 11.5 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin COP-gamma_platf PF08752.5 ESA11201.1 - 1.7e-61 206.4 3.9 2.7e-61 205.7 2.7 1.3 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain UPF0118 PF01594.11 ESA11203.1 - 0.028 13.3 5.1 0.034 13.1 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF20 zf-DHHC PF01529.15 ESA11203.1 - 1.5 8.1 4.1 2 7.8 2.9 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF3139 PF11337.3 ESA11203.1 - 3.4 8.0 7.7 11 6.4 5.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) Sel1 PF08238.7 ESA11204.1 - 3.9e-120 389.6 71.9 3.9e-12 46.3 0.7 14.9 15 0 0 15 15 15 14 Sel1 repeat TPR_6 PF13174.1 ESA11204.1 - 0.045 14.2 31.6 18 6.0 0.0 10.5 12 0 0 12 12 12 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11204.1 - 0.061 13.5 33.2 5 7.5 0.0 11.2 10 2 1 11 11 11 0 Tetratricopeptide repeat O-FucT PF10250.4 ESA11205.1 - 2.8e-11 43.1 5.6 2.8e-10 39.8 3.9 2.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase F-box-like PF12937.2 ESA11208.1 - 3.2e-05 23.5 0.2 3.2e-05 23.5 0.2 2.2 3 0 0 3 3 3 1 F-box-like LRR_6 PF13516.1 ESA11208.1 - 0.00037 20.2 8.8 4.4 7.6 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich repeat F-box PF00646.28 ESA11208.1 - 0.038 13.6 1.3 0.11 12.2 0.0 2.5 2 0 0 2 2 2 0 F-box domain PSDC PF12588.3 ESA11210.1 - 0.079 12.5 0.2 0.2 11.2 0.0 1.6 2 0 0 2 2 2 0 Phophatidylserine decarboxylase SET PF00856.23 ESA11211.1 - 5.9e-08 33.1 0.0 1.3e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 SET domain TPR_12 PF13424.1 ESA11211.1 - 7.2e-05 22.6 0.1 0.00017 21.4 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA11211.1 - 0.0057 16.3 0.2 0.024 14.3 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA11211.1 - 0.022 14.6 1.1 0.1 12.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA11211.1 - 0.052 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2769 PF10967.3 ESA11211.1 - 0.059 13.6 1.3 0.11 12.7 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2769) DUF2225 PF09986.4 ESA11211.1 - 0.063 12.7 0.2 0.063 12.7 0.1 1.9 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_10 PF13374.1 ESA11211.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA11212.1 - 3.2e-156 504.3 94.3 3.1e-11 43.5 0.8 17.8 18 0 0 18 18 18 17 Sel1 repeat TPR_6 PF13174.1 ESA11212.1 - 1.2e-05 25.4 39.3 1.4 9.5 0.0 12.8 14 1 0 14 14 14 4 Tetratricopeptide repeat RR_TM4-6 PF06459.7 ESA11213.1 - 0.048 13.5 4.0 0.053 13.4 2.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.3 ESA11213.1 - 0.096 11.2 1.6 0.11 11.0 1.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NARP1 PF12569.3 ESA11213.1 - 1.1 7.9 7.6 1.2 7.8 5.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Vfa1 PF08432.5 ESA11213.1 - 1.2 9.0 7.4 1.4 8.8 5.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 HpaP PF09483.5 ESA11213.1 - 4.3 7.2 13.7 5.3 6.9 9.5 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) DUF3275 PF11679.3 ESA11213.1 - 7.1 6.1 6.8 8 6.0 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Peptidase_M16_C PF05193.16 ESA11215.1 - 2.3e-22 79.5 2.7 1.5e-09 37.8 0.0 4.0 4 1 0 4 4 4 2 Peptidase M16 inactive domain DUF1664 PF07889.7 ESA11215.1 - 0.04 13.7 0.3 0.12 12.1 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) AATase PF07247.7 ESA11216.1 - 0.079 11.4 0.1 0.086 11.3 0.1 1.0 1 0 0 1 1 1 0 Alcohol acetyltransferase DUF1548 PF07579.6 ESA11217.1 - 0.27 11.3 6.8 2.7 8.1 1.1 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) BTB PF00651.26 ESA11218.1 - 1.1e-15 57.5 1.6 3.2e-14 52.8 0.2 2.3 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA11218.1 - 5.7e-09 36.1 0.2 1e-08 35.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA11218.1 - 0.0093 16.0 0.1 0.39 10.8 0.0 3.1 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain CAGE1 PF15066.1 ESA11218.1 - 0.041 12.3 0.1 0.064 11.6 0.1 1.2 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family Dimer_Tnp_hAT PF05699.9 ESA11220.1 - 6.4e-16 57.7 0.1 6.9e-16 57.6 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region UQ_con PF00179.21 ESA11221.1 - 9.9e-12 44.4 1.6 2.3e-11 43.2 1.1 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Sec23_trunk PF04811.10 ESA11223.1 - 3.1e-80 269.0 0.0 4.3e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESA11223.1 - 1.5e-35 120.7 0.2 3e-35 119.7 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESA11223.1 - 3.7e-31 107.4 0.3 6.7e-31 106.6 0.2 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESA11223.1 - 1.4e-17 62.9 5.8 3.2e-17 61.8 4.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 ESA11223.1 - 6.5e-14 51.3 0.0 1.7e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat T2SM PF04612.7 ESA11224.1 - 0.069 12.9 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M muHD PF10291.4 ESA11225.1 - 2e-51 174.6 0.7 2.9e-51 174.1 0.0 1.7 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain FCH PF00611.18 ESA11225.1 - 3.6e-16 59.1 5.9 2.3e-13 50.1 0.0 3.5 3 0 0 3 3 3 2 Fes/CIP4, and EFC/F-BAR homology domain RhoGEF PF00621.15 ESA11225.1 - 0.00064 19.6 2.0 0.0012 18.7 1.4 1.4 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.13 ESA11225.1 - 0.0084 15.6 7.0 0.025 14.0 4.9 1.6 1 1 0 1 1 1 1 BAR domain Ku_C PF03730.9 ESA11225.1 - 0.012 16.1 1.2 0.049 14.1 0.8 2.0 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm RapA_C PF12137.3 ESA11225.1 - 0.017 13.9 3.6 0.029 13.1 2.5 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Sec8_exocyst PF04048.9 ESA11225.1 - 0.31 10.6 8.3 0.13 11.9 2.7 2.4 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain TMPIT PF07851.8 ESA11225.1 - 0.31 10.0 3.0 0.48 9.4 2.1 1.3 1 0 0 1 1 1 0 TMPIT-like protein DAO PF01266.19 ESA11226.1 - 7e-54 183.0 0.0 8.2e-54 182.8 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESA11226.1 - 0.00065 19.6 0.5 0.037 13.8 0.3 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA11226.1 - 0.0045 16.7 0.3 0.85 9.3 0.0 2.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA11226.1 - 0.01 15.8 0.1 0.063 13.3 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 ESA11226.1 - 0.01 14.6 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 ESA11226.1 - 0.069 12.0 0.2 0.77 8.6 0.1 2.1 1 1 1 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.22 ESA11226.1 - 0.13 12.7 0.1 0.28 11.6 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Choline_kinase PF01633.15 ESA11227.1 - 0.0022 17.6 0.4 0.0045 16.5 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase Phage_XkdX PF09693.5 ESA11227.1 - 0.084 12.4 0.1 0.89 9.1 0.1 2.5 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) Myb_DNA-bind_4 PF13837.1 ESA11228.1 - 0.0016 18.5 0.2 0.0033 17.5 0.1 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA11228.1 - 0.0075 16.3 0.2 0.013 15.5 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain ADH_zinc_N PF00107.21 ESA11229.1 - 1.6e-24 85.8 0.0 2.5e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 ESA11229.1 - 0.00032 20.6 0.0 0.00054 19.9 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 ESA11229.1 - 0.0071 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 ESA11229.1 - 0.0089 15.6 0.3 0.014 14.9 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Met_10 PF02475.11 ESA11229.1 - 0.016 14.8 0.1 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein F420_oxidored PF03807.12 ESA11229.1 - 0.028 14.8 0.3 0.056 13.8 0.0 1.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Saccharop_dh PF03435.13 ESA11229.1 - 0.036 13.0 0.0 0.049 12.5 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase UDPG_MGDP_dh_N PF03721.9 ESA11229.1 - 0.047 13.0 0.0 0.071 12.4 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_18 PF12847.2 ESA11229.1 - 0.097 13.2 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ThiF PF00899.16 ESA11229.1 - 0.22 11.3 1.7 0.54 10.0 0.5 2.0 1 1 1 2 2 2 0 ThiF family MULE PF10551.4 ESA11231.1 - 2.8e-05 24.1 0.0 2.8e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 MULE transposase domain EOS1 PF12326.3 ESA11235.1 - 0.018 14.6 3.0 0.021 14.4 2.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein Humanin PF15040.1 ESA11235.1 - 0.04 13.1 0.5 0.1 11.8 0.4 1.8 1 0 0 1 1 1 0 Humanin family F-box-like PF12937.2 ESA11236.1 - 4.6e-05 23.0 1.2 7.8e-05 22.3 0.8 1.4 1 0 0 1 1 1 1 F-box-like Herpes_IE68 PF02479.11 ESA11236.1 - 0.02 14.0 0.3 1.3 8.2 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus immediate early protein DnaJ PF00226.26 ESA11237.1 - 1e-28 98.8 1.5 1e-28 98.8 1.0 2.2 2 1 0 2 2 2 1 DnaJ domain SHNi-TPR PF10516.4 ESA11237.1 - 0.0035 16.5 0.2 0.012 14.8 0.1 1.8 1 0 0 1 1 1 1 SHNi-TPR TPR_1 PF00515.23 ESA11237.1 - 0.0093 15.5 0.2 0.58 9.8 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat LMBR1 PF04791.11 ESA11237.1 - 0.035 12.6 0.7 0.042 12.4 0.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_19 PF14559.1 ESA11237.1 - 0.051 13.9 0.5 0.89 9.9 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_10 PF04967.7 ESA11237.1 - 0.057 12.9 0.8 1.7 8.2 0.1 2.4 1 1 1 2 2 2 0 HTH DNA binding domain Thioredoxin_8 PF13905.1 ESA11237.1 - 0.086 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like TPR_2 PF07719.12 ESA11237.1 - 0.097 12.6 2.4 1.4 9.0 0.1 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Mhr1 PF12829.2 ESA11237.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination TPR_14 PF13428.1 ESA11237.1 - 0.14 12.8 0.2 7.4 7.5 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA11237.1 - 0.19 11.5 2.0 4.7 7.2 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3452 PF11934.3 ESA11241.1 - 0.056 12.7 1.1 0.065 12.5 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) WD40 PF00400.27 ESA11242.1 - 9.5e-05 22.1 2.2 0.46 10.4 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat F-box-like PF12937.2 ESA11243.1 - 0.027 14.2 0.8 0.061 13.0 0.6 1.6 1 0 0 1 1 1 0 F-box-like DUF2119 PF09892.4 ESA11245.1 - 0.082 12.1 0.1 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) TcdA_TcdB_pore PF12920.2 ESA11246.1 - 0.091 10.6 0.3 0.093 10.6 0.2 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Shisa PF13908.1 ESA11247.1 - 0.00098 19.3 0.1 0.0012 19.0 0.1 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 ESA11247.1 - 0.0015 18.2 1.0 0.0019 17.9 0.7 1.2 1 0 0 1 1 1 1 TMEM154 protein family PepSY_TM_2 PF13703.1 ESA11247.1 - 0.0044 17.1 0.1 0.0067 16.5 0.1 1.2 1 0 0 1 1 1 1 PepSY-associated TM helix Herpes_gE PF02480.11 ESA11247.1 - 0.005 15.1 0.0 0.0052 15.1 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Peptidase_M56 PF05569.6 ESA11247.1 - 0.0075 15.2 1.4 0.015 14.2 1.0 1.5 1 1 0 1 1 1 1 BlaR1 peptidase M56 LRRC37AB_C PF14914.1 ESA11247.1 - 0.013 14.9 0.4 0.02 14.3 0.3 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Baculo_11_kDa PF06143.6 ESA11247.1 - 0.013 14.8 2.6 0.021 14.1 1.8 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4448 PF14610.1 ESA11247.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF1049 PF06305.6 ESA11247.1 - 0.023 14.1 1.2 0.039 13.4 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) HemY_N PF07219.8 ESA11247.1 - 0.028 13.9 0.4 0.042 13.3 0.3 1.3 1 0 0 1 1 1 0 HemY protein N-terminus Protocadherin PF08374.6 ESA11247.1 - 0.038 13.6 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 Protocadherin SID-1_RNA_chan PF13965.1 ESA11247.1 - 0.043 12.0 0.2 0.042 12.0 0.1 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ABC2_membrane_3 PF12698.2 ESA11247.1 - 0.044 12.8 0.1 0.053 12.5 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4381 PF14316.1 ESA11247.1 - 0.048 13.7 0.2 0.065 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.1 ESA11247.1 - 0.048 14.0 1.9 0.048 14.0 1.3 1.8 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Rifin_STEVOR PF02009.11 ESA11247.1 - 0.048 13.2 1.9 0.061 12.9 1.3 1.2 1 0 0 1 1 1 0 Rifin/stevor family DUF1180 PF06679.7 ESA11247.1 - 0.06 13.2 0.2 0.076 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4446 PF14584.1 ESA11247.1 - 0.078 12.8 0.4 0.097 12.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF912 PF06024.7 ESA11247.1 - 0.098 12.7 3.8 0.058 13.4 1.4 1.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) YajC PF02699.10 ESA11247.1 - 0.1 12.2 1.1 0.16 11.6 0.7 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit DUF2207 PF09972.4 ESA11247.1 - 0.11 11.0 0.1 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ODV-E18 PF10717.4 ESA11247.1 - 0.19 11.2 7.4 0.23 10.9 4.6 1.5 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF3753 PF12575.3 ESA11247.1 - 0.37 10.6 2.9 0.61 9.9 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) NS3_envE PF02723.9 ESA11247.1 - 0.64 9.9 5.6 1.6 8.6 3.9 1.6 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E RCR PF12273.3 ESA11247.1 - 7.2 7.1 8.0 25 5.4 5.5 1.9 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red FGase PF05013.7 ESA11248.1 - 3.3e-06 27.1 0.0 0.0014 18.5 0.0 2.8 2 1 0 2 2 2 1 N-formylglutamate amidohydrolase ubiquitin PF00240.18 ESA11250.1 - 5.1e-22 77.0 0.2 9.1e-22 76.2 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA11250.1 - 4.5e-11 42.2 0.1 8.2e-11 41.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA11250.1 - 0.0014 18.8 0.0 0.0031 17.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain PARP PF00644.15 ESA11250.1 - 0.0093 15.4 0.3 0.044 13.2 0.0 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ESA11250.1 - 0.022 14.1 0.2 0.039 13.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Med13_C PF06333.7 ESA11252.1 - 0.0011 17.5 0.1 0.0012 17.4 0.1 1.0 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal Not3 PF04065.10 ESA11253.1 - 1.3e-100 335.4 28.3 2.4e-100 334.6 19.6 1.4 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 ESA11253.1 - 6.8e-48 161.9 11.5 4.3e-47 159.3 7.9 2.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Cep57_MT_bd PF06657.8 ESA11253.1 - 0.013 15.3 5.5 0.037 13.9 0.3 2.9 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 FlaC_arch PF05377.6 ESA11253.1 - 2.8 7.8 6.7 3.9 7.4 1.0 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 ESA11253.1 - 2.9 7.4 13.6 0.56 9.7 0.5 3.3 2 1 0 2 2 2 0 Septum formation initiator zf-CCHC_3 PF13917.1 ESA11254.1 - 9.2e-19 66.9 4.6 1.3e-18 66.4 3.2 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 ESA11254.1 - 0.0058 16.5 2.0 0.0081 16.0 1.4 1.2 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.3 ESA11254.1 - 0.031 14.1 1.4 0.038 13.9 1.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_5 PF14787.1 ESA11254.1 - 0.083 12.3 0.7 0.12 11.8 0.5 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Rtf2 PF04641.7 ESA11255.1 - 8.3e-77 257.8 9.3 1e-76 257.6 6.4 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 ESA11255.1 - 0.00046 19.6 0.6 0.1 12.1 0.0 2.6 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 ESA11255.1 - 0.0086 16.0 0.0 0.047 13.6 0.0 2.3 2 1 0 2 2 2 1 U-box domain zf-RING_UBOX PF13445.1 ESA11255.1 - 0.0098 15.5 2.7 0.016 14.8 1.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Baculo_VP39 PF04501.7 ESA11255.1 - 0.033 13.1 0.0 0.049 12.6 0.0 1.3 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 zf-RING_2 PF13639.1 ESA11255.1 - 0.054 13.3 0.6 0.56 10.0 0.8 2.1 1 1 1 2 2 2 0 Ring finger domain CMV_1a PF12467.3 ESA11255.1 - 0.74 10.1 9.6 1.2 9.5 6.7 1.3 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family zf-LYAR PF08790.6 ESA11255.1 - 0.79 9.4 3.6 0.44 10.2 0.3 2.1 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Atg8 PF02991.11 ESA11256.1 - 8.9e-52 173.4 0.2 1e-51 173.1 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 ESA11256.1 - 1.4e-06 28.4 0.0 1.7e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SRA1 PF07304.6 ESA11257.1 - 3.7e-06 26.7 0.0 4.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.10 ESA11257.1 - 1.7e-05 24.6 0.7 5.8e-05 22.9 0.3 1.8 1 1 1 2 2 2 1 Prp18 domain DUF963 PF06131.6 ESA11257.1 - 0.075 12.3 4.3 0.14 11.4 3.0 1.4 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) P3A PF08727.6 ESA11257.1 - 0.088 12.1 0.1 1.4 8.3 0.0 2.4 1 1 1 2 2 2 0 Poliovirus 3A protein like TLD PF07534.11 ESA11259.1 - 2.8e-07 30.6 0.4 4e-07 30.0 0.3 1.3 1 0 0 1 1 1 1 TLD TcdB_N PF12918.2 ESA11259.1 - 0.002 18.1 0.2 0.0044 17.0 0.1 1.7 1 1 0 1 1 1 1 TcdB toxin N-terminal helical domain Peptidase_S66 PF02016.10 ESA11259.1 - 0.046 12.6 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 LD-carboxypeptidase DUF1323 PF07037.6 ESA11260.1 - 0.021 14.9 0.1 0.077 13.1 0.0 1.9 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) DUF328 PF03883.9 ESA11261.1 - 0.098 11.9 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF328) DUF3669 PF12417.3 ESA11261.1 - 0.13 11.9 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Zinc finger protein Fork_head PF00250.13 ESA11261.1 - 0.2 11.7 3.0 0.23 11.5 0.6 1.9 1 1 1 2 2 2 0 Fork head domain HMG_box PF00505.14 ESA11263.1 - 8e-07 29.2 2.1 1e-06 28.8 0.4 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA11263.1 - 0.00065 20.0 2.0 0.00095 19.4 0.2 2.0 2 0 0 2 2 2 1 HMG-box domain Mito_carr PF00153.22 ESA11265.1 - 8.1e-41 137.6 2.3 1.3e-17 63.2 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF2157 PF09925.4 ESA11265.1 - 1.1 8.8 4.1 7.1 6.2 0.6 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Mucin PF01456.12 ESA11267.1 - 0.032 14.0 8.4 0.056 13.2 5.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein TPR_11 PF13414.1 ESA11268.1 - 2.1e-30 104.1 25.4 6.2e-11 41.7 0.5 5.5 2 2 2 6 6 6 5 TPR repeat TPR_2 PF07719.12 ESA11268.1 - 7.9e-30 100.3 24.9 0.00032 20.3 0.0 9.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESA11268.1 - 6.3e-24 82.5 41.0 2.4e-07 30.0 0.1 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 ESA11268.1 - 1.3e-15 55.8 40.8 3.1e-05 23.4 0.1 9.2 8 1 1 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11268.1 - 5.6e-15 54.2 19.7 0.04 14.1 0.1 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA11268.1 - 3.9e-14 52.8 0.0 0.028 15.0 0.0 6.1 4 2 1 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA11268.1 - 6.3e-12 45.2 14.9 0.0001 22.1 0.2 5.6 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA11268.1 - 4.8e-11 42.2 0.0 0.79 10.5 0.0 7.8 4 2 5 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA11268.1 - 2.2e-10 40.2 1.3 0.23 11.9 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA11268.1 - 4.3e-10 39.5 27.4 1.1e-05 25.4 1.8 4.9 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA11268.1 - 3.5e-09 36.8 1.6 0.081 13.2 0.0 4.8 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA11268.1 - 2e-07 30.7 0.0 0.22 11.4 0.0 5.0 3 2 1 5 5 5 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA11268.1 - 0.0034 16.5 0.9 0.25 10.6 0.0 4.1 5 0 0 5 5 5 1 SHNi-TPR zf-C3HC4_3 PF13920.1 ESA11268.1 - 0.0093 15.6 1.7 0.0093 15.6 1.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) TPR_15 PF13429.1 ESA11268.1 - 0.0093 15.0 0.0 0.022 13.8 0.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat zf-RING_2 PF13639.1 ESA11268.1 - 0.046 13.5 4.9 0.043 13.6 1.4 2.4 2 0 0 2 2 2 0 Ring finger domain TPR_7 PF13176.1 ESA11268.1 - 0.056 13.2 7.2 6.4 6.8 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat zf-RING_5 PF14634.1 ESA11268.1 - 0.074 12.7 5.3 0.057 13.1 1.6 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Fis1_TPR_C PF14853.1 ESA11268.1 - 0.1 12.4 13.0 12 5.8 0.0 6.0 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat CENP-F_leu_zip PF10473.4 ESA11270.1 - 0.0008 19.2 7.1 0.0008 19.2 4.9 2.0 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PhaP_Bmeg PF09602.5 ESA11270.1 - 0.0021 17.8 10.8 0.11 12.3 3.0 2.1 1 1 1 2 2 2 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) TMF_DNA_bd PF12329.3 ESA11270.1 - 0.0021 17.7 13.8 0.0021 17.7 9.5 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF4435 PF14491.1 ESA11270.1 - 0.0021 17.9 8.0 0.0027 17.5 5.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4435) Bacillus_HBL PF05791.6 ESA11270.1 - 0.0096 15.3 8.4 0.35 10.2 1.5 2.2 2 0 0 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) Bac_GDH PF05088.7 ESA11270.1 - 0.012 13.0 6.5 0.012 13.0 4.5 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DUF4337 PF14235.1 ESA11270.1 - 0.012 15.4 4.4 0.012 15.4 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DUF948 PF06103.6 ESA11270.1 - 0.013 15.3 5.2 0.51 10.2 1.4 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HrpB7 PF09486.5 ESA11270.1 - 0.016 15.1 3.3 0.016 15.1 2.3 1.7 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Phage_GP20 PF06810.6 ESA11270.1 - 0.019 14.4 10.1 0.019 14.4 7.0 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 T2SG PF08334.6 ESA11270.1 - 0.066 12.9 0.7 0.12 12.1 0.2 1.6 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein G TBPIP PF07106.8 ESA11270.1 - 0.068 12.7 17.2 0.024 14.1 4.9 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) PspA_IM30 PF04012.7 ESA11270.1 - 0.086 12.1 11.7 0.029 13.7 4.6 2.0 2 0 0 2 2 2 0 PspA/IM30 family DUF3316 PF11777.3 ESA11270.1 - 0.1 12.3 1.4 0.2 11.4 0.2 2.0 1 1 0 2 2 1 0 Protein of unknown function (DUF3316) Cluap1 PF10234.4 ESA11270.1 - 0.18 10.9 10.8 0.12 11.6 3.8 2.0 2 0 0 2 2 2 0 Clusterin-associated protein-1 HisKA_3 PF07730.8 ESA11270.1 - 0.2 12.0 3.1 14 6.1 0.5 2.8 2 2 0 2 2 2 0 Histidine kinase Spc7 PF08317.6 ESA11270.1 - 0.21 10.2 18.3 0.015 13.9 5.4 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Lzipper-MIP1 PF14389.1 ESA11270.1 - 0.22 11.6 9.6 0.57 10.3 2.9 2.8 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 CENP-Q PF13094.1 ESA11270.1 - 0.24 11.4 18.9 1.7 8.6 13.1 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Laminin_I PF06008.9 ESA11270.1 - 0.24 10.6 13.6 1.1 8.4 9.4 1.9 1 1 0 1 1 1 0 Laminin Domain I Metal_resist PF13801.1 ESA11270.1 - 0.25 11.3 1.7 1.2 9.1 1.1 1.9 2 0 0 2 2 2 0 Heavy-metal resistance Baculo_PEP_C PF04513.7 ESA11270.1 - 0.38 10.5 2.3 0.67 9.7 0.3 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.6 ESA11270.1 - 0.42 11.0 12.2 0.84 10.0 3.5 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Uds1 PF15456.1 ESA11270.1 - 0.43 10.5 9.2 1.5 8.8 6.3 1.8 1 1 0 1 1 1 0 Up-regulated During Septation WEMBL PF05701.6 ESA11270.1 - 0.44 8.9 17.4 0.087 11.2 4.9 2.0 2 0 0 2 2 2 0 Weak chloroplast movement under blue light Med4 PF10018.4 ESA11270.1 - 0.5 9.7 10.0 0.91 8.8 6.9 1.6 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 FliD_C PF07195.7 ESA11270.1 - 0.63 9.2 8.5 0.18 11.0 1.8 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Apolipoprotein PF01442.13 ESA11270.1 - 0.69 9.3 15.1 4.3 6.7 10.5 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Laminin_II PF06009.7 ESA11270.1 - 0.73 9.5 9.1 1.2 8.8 1.8 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.7 ESA11270.1 - 0.75 9.6 7.2 0.7 9.6 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ran-binding PF05508.6 ESA11270.1 - 0.79 8.5 9.5 0.39 9.5 0.9 2.1 1 1 0 2 2 2 0 RanGTP-binding protein Cob_adeno_trans PF01923.13 ESA11270.1 - 0.81 9.4 5.8 0.38 10.5 1.6 1.9 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Sds3 PF08598.6 ESA11270.1 - 0.84 9.1 13.4 0.25 10.8 0.4 2.2 2 0 0 2 2 2 0 Sds3-like DUF4145 PF13643.1 ESA11270.1 - 0.9 9.4 7.0 0.64 9.9 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) Pox_A_type_inc PF04508.7 ESA11270.1 - 1.1 9.2 0.1 1.1 9.2 0.1 4.3 3 1 2 5 5 5 0 Viral A-type inclusion protein repeat CASP_C PF08172.7 ESA11270.1 - 1.1 8.1 11.2 0.87 8.5 6.2 1.8 1 1 1 2 2 2 0 CASP C terminal Snapin_Pallidin PF14712.1 ESA11270.1 - 1.1 9.5 14.7 2 8.8 3.7 2.4 2 1 0 2 2 2 0 Snapin/Pallidin Exonuc_VII_L PF02601.10 ESA11270.1 - 1.2 8.2 10.2 1.6 7.8 7.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.4 ESA11270.1 - 1.3 9.2 15.7 5 7.3 1.2 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OmpH PF03938.9 ESA11270.1 - 1.3 8.9 16.1 2.1 8.2 11.2 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Sipho_Gp157 PF05565.6 ESA11270.1 - 1.3 8.5 12.4 0.1 12.1 3.3 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 DivIVA PF05103.8 ESA11270.1 - 1.4 9.0 13.2 0.41 10.7 3.9 2.4 2 0 0 2 2 2 0 DivIVA protein Mod_r PF07200.8 ESA11270.1 - 1.6 8.6 13.6 4.9 7.0 4.7 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF3584 PF12128.3 ESA11270.1 - 1.6 5.9 13.7 2.2 5.5 9.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Sec8_exocyst PF04048.9 ESA11270.1 - 1.8 8.2 8.4 3.8 7.1 1.4 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Tropomyosin_1 PF12718.2 ESA11270.1 - 1.9 8.3 21.2 0.19 11.5 8.2 2.1 2 0 0 2 2 2 0 Tropomyosin like ATG16 PF08614.6 ESA11270.1 - 2.1 8.1 18.4 0.75 9.5 6.0 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.15 ESA11270.1 - 2.3 7.2 20.3 0.11 11.5 7.4 2.0 2 0 0 2 2 2 0 Tropomyosin Rootletin PF15035.1 ESA11270.1 - 2.4 8.0 17.3 0.39 10.6 7.2 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ISG65-75 PF11727.3 ESA11270.1 - 2.8 6.9 13.9 3.7 6.5 2.9 2.0 1 1 0 2 2 2 0 Invariant surface glycoprotein FliD_N PF02465.13 ESA11270.1 - 2.8 8.3 7.1 0.93 9.8 1.4 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Lectin_N PF03954.9 ESA11270.1 - 2.9 7.3 5.7 4.6 6.6 1.5 2.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Filament PF00038.16 ESA11270.1 - 3.4 7.0 18.2 7 6.0 12.6 1.5 1 1 0 1 1 1 0 Intermediate filament protein ADIP PF11559.3 ESA11270.1 - 3.7 7.4 14.8 0.36 10.7 5.2 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.1 ESA11270.1 - 3.7 6.4 13.2 2 7.2 4.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) YlqD PF11068.3 ESA11270.1 - 3.8 7.5 14.4 1.2 9.1 5.4 2.1 2 0 0 2 2 2 0 YlqD protein Prefoldin_2 PF01920.15 ESA11270.1 - 4.1 7.2 24.1 0.53 10.0 1.8 3.2 2 1 1 3 3 3 0 Prefoldin subunit AAA_13 PF13166.1 ESA11270.1 - 4.1 5.7 19.1 0.21 9.9 5.8 1.9 1 1 0 2 2 2 0 AAA domain IncA PF04156.9 ESA11270.1 - 4.1 6.9 21.4 2 7.9 8.5 2.0 2 0 0 2 2 2 0 IncA protein Ax_dynein_light PF10211.4 ESA11270.1 - 4.4 7.1 15.4 1 9.1 5.3 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain TPR_MLP1_2 PF07926.7 ESA11270.1 - 4.5 7.0 21.8 1.1e+02 2.5 15.1 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.4 ESA11270.1 - 4.6 7.4 9.8 2.1e+02 2.1 6.8 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Seryl_tRNA_N PF02403.17 ESA11270.1 - 4.6 7.3 19.6 0.63 10.0 5.7 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SopA_C PF13979.1 ESA11270.1 - 4.7 6.7 9.3 0.39 10.2 0.3 2.0 2 0 0 2 2 2 0 SopA-like catalytic domain Fzo_mitofusin PF04799.8 ESA11270.1 - 5.9 6.2 8.4 1.3 8.3 2.1 2.0 2 0 0 2 2 2 0 fzo-like conserved region DUF3573 PF12097.3 ESA11270.1 - 6 5.3 8.5 3 6.3 4.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) DUF3373 PF11853.3 ESA11270.1 - 6.1 5.2 8.0 0.49 8.8 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3373) DUF4546 PF15079.1 ESA11270.1 - 6.7 5.7 12.4 7.2 5.6 3.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4546) Atg14 PF10186.4 ESA11270.1 - 6.9 5.5 13.6 0.44 9.4 4.3 1.9 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 ESA11270.1 - 6.9 5.6 19.3 0.31 10.0 6.7 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF972 PF06156.8 ESA11270.1 - 6.9 7.0 17.6 0.39 11.0 5.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FlaC_arch PF05377.6 ESA11270.1 - 8 6.4 11.3 6.9 6.6 1.1 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) AATF-Che1 PF13339.1 ESA11270.1 - 8.7 6.5 13.3 2.3e+02 1.9 9.2 2.1 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Fib_alpha PF08702.5 ESA11270.1 - 8.8 6.4 12.8 1.8e+02 2.2 8.9 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Mt_ATP-synt_B PF05405.9 ESA11270.1 - 8.8 5.7 14.2 0.82 9.1 0.3 2.6 2 1 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Nop25 PF09805.4 ESA11270.1 - 9.1 6.3 15.0 2 8.5 1.3 2.2 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DUF3069 PF11269.3 ESA11270.1 - 9.7 6.2 7.4 1.8 8.6 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3069) RRF PF01765.14 ESA11270.1 - 9.8 5.6 15.8 1.4 8.3 4.1 2.1 2 0 0 2 2 2 0 Ribosome recycling factor Gp-FAR-1 PF05823.7 ESA11271.1 - 0.0005 20.0 2.6 0.058 13.3 1.0 2.2 1 1 0 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) SEA PF01390.15 ESA11271.1 - 0.032 13.8 0.4 0.91 9.2 0.1 2.3 2 0 0 2 2 2 0 SEA domain DUF3508 PF12018.3 ESA11271.1 - 0.057 12.3 3.8 0.077 11.9 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) IF3_C PF00707.17 ESA11271.1 - 0.072 12.8 2.1 0.68 9.7 0.2 2.5 2 1 0 2 2 2 0 Translation initiation factor IF-3, C-terminal domain Baculo_PEP_C PF04513.7 ESA11271.1 - 0.081 12.7 2.1 1.1 9.1 0.1 2.5 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus THDPS_N_2 PF14805.1 ESA11271.1 - 0.11 12.4 1.6 5.5 6.9 0.0 3.2 3 0 0 3 3 3 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Syntaxin_2 PF14523.1 ESA11271.1 - 0.2 11.7 5.8 2.1 8.4 0.6 2.3 1 1 1 2 2 2 0 Syntaxin-like protein TnpV PF14198.1 ESA11271.1 - 0.23 11.3 3.7 0.58 10.0 2.6 1.7 1 0 0 1 1 1 0 Transposon-encoded protein TnpV SopA PF13981.1 ESA11271.1 - 0.26 11.2 6.1 4.8 7.2 0.1 2.2 1 1 0 2 2 2 0 SopA-like central domain RIH_assoc PF08454.6 ESA11271.1 - 0.48 10.0 5.3 0.29 10.7 1.7 1.8 2 0 0 2 2 2 0 RyR and IP3R Homology associated YtxH PF12732.2 ESA11271.1 - 0.77 10.1 4.4 10 6.5 3.0 2.6 1 1 0 1 1 1 0 YtxH-like protein DUF740 PF05340.7 ESA11271.1 - 1.2 7.4 4.5 1.5 7.1 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) RNA_pol_Rpb1_4 PF05000.12 ESA11271.1 - 8.7 6.1 7.5 12 5.6 0.7 2.7 1 1 2 3 3 3 0 RNA polymerase Rpb1, domain 4 DDE_Tnp_ISAZ013 PF07592.6 ESA11273.1 - 0.00018 20.4 0.0 0.17 10.5 0.0 2.3 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain zf-C2H2_4 PF13894.1 ESA11274.1 - 0.0016 18.6 2.8 0.0067 16.6 2.0 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA11274.1 - 0.014 15.3 0.5 0.034 14.0 0.3 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA11274.1 - 5.7 7.4 8.8 5.7 7.4 0.9 3.0 2 0 0 2 2 2 0 Zinc-finger double domain PXB PF12828.2 ESA11276.1 - 0.074 12.6 0.6 8.4 6.0 0.1 2.3 2 0 0 2 2 2 0 PX-associated Phage_C PF12025.3 ESA11276.1 - 3.2 7.7 10.0 2.6 8.0 0.3 3.5 3 0 0 3 3 3 0 Phage protein C fn1 PF00039.13 ESA11276.1 - 6.2 6.7 8.3 21 5.0 0.1 3.6 3 0 0 3 3 3 0 Fibronectin type I domain Pkinase_Tyr PF07714.12 ESA11277.1 - 3.8e-20 72.0 0.0 5.8e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11277.1 - 2.1e-17 63.1 0.0 3.6e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11277.1 - 1.2e-13 51.2 8.9 3.7e-07 30.5 0.4 3.4 3 1 1 4 4 4 2 Sel1 repeat TPR_6 PF13174.1 ESA11277.1 - 0.0065 16.8 4.3 7 7.3 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Sec-ASP3 PF15432.1 ESA11279.1 - 0.24 11.3 2.0 7.2 6.5 0.1 2.1 1 1 1 2 2 2 0 Accessory Sec secretory system ASP3 bZIP_C PF12498.3 ESA11279.1 - 4.9 8.4 7.8 22 6.2 0.3 2.1 1 1 0 2 2 2 0 Basic leucine-zipper C terminal Nuc_recep-AF1 PF11825.3 ESA11279.1 - 5.6 6.9 9.6 0.66 9.9 3.6 1.6 2 0 0 2 2 2 0 Nuclear/hormone receptor activator site AF-1 Pkinase_Tyr PF07714.12 ESA11280.1 - 1.7e-13 50.2 0.1 2.2e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11280.1 - 6.3e-12 45.1 2.4 7.6e-12 44.9 1.7 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA11280.1 - 0.022 14.0 2.2 0.048 12.9 1.4 1.8 1 1 0 1 1 1 0 RIO1 family APH PF01636.18 ESA11280.1 - 0.15 11.8 0.2 0.19 11.4 0.2 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family NUC173 PF08161.7 ESA11281.1 - 1.1e-64 217.4 7.6 4.6e-64 215.4 0.4 3.7 3 0 0 3 3 3 2 NUC173 domain Sensor PF13796.1 ESA11282.1 - 0.29 10.7 5.2 0.43 10.1 3.6 1.3 1 0 0 1 1 1 0 Putative sensor HATPase_c_3 PF13589.1 ESA11283.1 - 7.4e-08 32.1 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3684 PF12449.3 ESA11283.1 - 1.4e-05 22.9 0.2 1.8e-05 22.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c PF02518.21 ESA11283.1 - 0.0002 21.0 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TLD PF07534.11 ESA11284.1 - 2.8e-19 69.4 1.2 2.8e-19 69.4 0.8 1.5 2 0 0 2 2 2 1 TLD HATPase_c_3 PF13589.1 ESA11285.1 - 1.9e-07 30.8 0.0 3.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3684 PF12449.3 ESA11285.1 - 1.6e-05 22.8 0.1 2e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c PF02518.21 ESA11285.1 - 0.00023 20.8 0.0 0.00047 19.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase V-SNARE PF05008.10 ESA11286.1 - 0.048 13.8 1.3 0.079 13.1 0.2 1.8 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF4041 PF13250.1 ESA11286.1 - 7.8 6.1 6.6 4.5 6.9 0.1 3.0 3 1 0 4 4 4 0 Domain of unknown function (DUF4041) Dimer_Tnp_hAT PF05699.9 ESA11287.1 - 0.00081 18.9 0.0 0.0033 17.0 0.0 2.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pet20 PF08692.5 ESA11287.1 - 0.12 12.3 1.3 0.28 11.1 0.4 2.0 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Pkinase PF00069.20 ESA11288.1 - 1.1e-18 67.3 0.3 1.4e-18 66.9 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11288.1 - 7.4e-17 61.2 0.0 8.5e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA11288.1 - 0.0095 15.0 0.2 0.015 14.3 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA11288.1 - 0.16 11.6 0.1 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tox-GHH PF15636.1 ESA11288.1 - 0.17 11.5 1.9 0.21 11.2 0.4 1.9 1 1 1 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin XFP PF03894.10 ESA11288.1 - 0.44 10.1 2.6 4.2 6.9 0.1 2.1 1 1 1 2 2 2 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase FKS1_dom1 PF14288.1 ESA11290.1 - 0.25 11.2 2.1 0.87 9.5 0.4 1.9 1 1 1 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF1620 PF07774.8 ESA11291.1 - 3.4e-65 219.3 0.0 5.1e-65 218.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) Sdh5 PF03937.11 ESA11292.1 - 2.2e-23 81.7 0.1 3e-23 81.2 0.1 1.1 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase p450 PF00067.17 ESA11293.1 - 1e-08 34.2 0.1 1.1e-08 34.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3951 PF13131.1 ESA11293.1 - 0.0071 16.0 2.5 0.014 15.1 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3951) TLD PF07534.11 ESA11294.1 - 3e-10 40.2 0.1 3.4e-10 40.0 0.1 1.0 1 0 0 1 1 1 1 TLD Jnk-SapK_ap_N PF09744.4 ESA11295.1 - 0.0052 16.8 9.6 0.0052 16.8 6.7 1.9 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Prp19 PF08606.6 ESA11295.1 - 0.17 11.6 2.8 10 5.9 0.2 2.5 2 1 0 2 2 2 0 Prp19/Pso4-like DUF4413 PF14372.1 ESA11296.1 - 0.00011 22.0 0.4 0.00036 20.4 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) RINGv PF12906.2 ESA11299.1 - 1.5e-07 31.3 10.8 2.5e-07 30.6 7.5 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 ESA11299.1 - 3e-05 23.7 5.7 5.1e-05 23.0 3.9 1.4 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.3 ESA11299.1 - 0.0026 17.6 6.7 0.0053 16.6 4.7 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_4 PF14570.1 ESA11299.1 - 0.016 14.8 5.4 0.03 13.9 3.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zinc_ribbon_5 PF13719.1 ESA11299.1 - 0.02 14.4 0.2 0.04 13.4 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 ESA11299.1 - 0.023 14.3 0.2 0.045 13.4 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 ESA11299.1 - 0.59 10.2 6.0 1.2 9.2 4.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA11299.1 - 0.72 9.5 5.4 1.2 8.8 3.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA11299.1 - 2.1 8.1 5.3 4 7.2 3.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain PHD PF00628.24 ESA11299.1 - 2.6 7.8 8.2 3.5 7.3 5.3 1.6 1 1 0 1 1 1 0 PHD-finger Complex1_LYR PF05347.10 ESA11300.1 - 2.2e-10 40.1 0.4 3.5e-10 39.5 0.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA11300.1 - 1.7e-08 34.5 0.1 3e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_2 PF13233.1 ESA11300.1 - 0.05 14.0 0.0 0.063 13.7 0.0 1.2 1 0 0 1 1 1 0 Complex1_LYR-like DUF1122 PF06557.6 ESA11300.1 - 0.11 11.6 0.1 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1122) Myb_DNA-binding PF00249.26 ESA11301.1 - 2.3e-11 43.5 0.3 3.8e-11 42.8 0.2 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA11301.1 - 1.7e-09 37.5 0.3 2.9e-09 36.8 0.2 1.5 1 1 0 1 1 1 1 Myb-like DNA-binding domain SAM_1 PF00536.25 ESA11302.1 - 3.1e-09 36.8 0.1 0.001 19.1 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Myb_DNA-binding PF00249.26 ESA11302.1 - 2.4e-08 33.9 0.1 1.1e-07 31.8 0.0 2.2 3 0 0 3 3 3 1 Myb-like DNA-binding domain RST PF12174.3 ESA11302.1 - 0.00058 19.6 0.3 0.86 9.4 0.0 2.6 2 0 0 2 2 2 2 RCD1-SRO-TAF4 (RST) plant domain Myb_DNA-bind_6 PF13921.1 ESA11302.1 - 0.00072 19.6 0.1 0.0025 17.8 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3785 PF12653.2 ESA11302.1 - 0.0078 16.0 2.5 0.19 11.5 0.7 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF3785) DUF2492 PF10678.4 ESA11302.1 - 0.0092 16.0 0.1 2 8.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2492) Med19 PF10278.4 ESA11302.1 - 0.036 13.7 0.0 3.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 EF-hand_like PF09279.6 ESA11302.1 - 0.11 12.5 0.8 1 9.3 0.5 2.5 1 1 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like ABC_membrane_3 PF13748.1 ESA11302.1 - 0.31 10.0 2.3 5.9 5.8 0.1 2.5 3 0 0 3 3 3 0 ABC transporter transmembrane region ZZ PF00569.12 ESA11303.1 - 6.7e-26 89.5 35.1 1.5e-09 37.2 6.7 3.4 3 0 0 3 3 3 3 Zinc finger, ZZ type CUE PF02845.11 ESA11303.1 - 0.05 13.0 0.1 0.2 11.1 0.1 2.1 1 0 0 1 1 1 0 CUE domain UBA PF00627.26 ESA11303.1 - 0.097 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain CN_hydrolase PF00795.17 ESA11305.1 - 2.7e-29 101.8 0.0 4.2e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 ESA11305.1 - 1.8e-25 89.2 0.0 5.1e-25 87.7 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 ESA11305.1 - 0.038 13.4 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase Histidinol_dh PF00815.15 ESA11306.1 - 5.9e-181 601.5 0.6 8e-181 601.1 0.4 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 ESA11306.1 - 9.2e-26 89.2 0.0 2e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 ESA11306.1 - 8.9e-10 38.7 0.0 2.1e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase Hep_59 PF07052.6 ESA11307.1 - 3.8e-33 113.9 2.5 3.8e-33 113.9 1.7 2.1 2 1 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 Tetraspannin PF00335.15 ESA11311.1 - 0.0038 16.5 11.7 0.0038 16.5 8.1 1.8 1 1 1 2 2 2 1 Tetraspanin family DUF1361 PF07099.6 ESA11311.1 - 0.018 14.8 5.4 0.14 12.0 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1361) Tmemb_161AB PF10268.4 ESA11311.1 - 0.078 11.4 3.3 0.093 11.2 2.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB Cation_ATPase_C PF00689.16 ESA11311.1 - 0.48 9.9 9.9 15 5.1 5.7 2.3 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus Bestrophin PF01062.16 ESA11311.1 - 5.1 5.9 7.1 7.6 5.3 0.0 2.2 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel Sel1 PF08238.7 ESA11312.1 - 1.4e-243 782.0 136.7 1.4e-12 47.7 0.7 23.0 23 0 0 23 23 23 23 Sel1 repeat MIT PF04212.13 ESA11312.1 - 0.39 10.6 80.9 6.1 6.8 0.0 17.9 17 4 2 19 19 19 0 MIT (microtubule interacting and transport) domain TP_methylase PF00590.15 ESA11313.1 - 2.2e-42 145.1 0.0 2.5e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF972 PF06156.8 ESA11314.1 - 0.00012 22.3 5.0 0.00012 22.3 3.5 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF972) bZIP_2 PF07716.10 ESA11314.1 - 0.0036 17.1 7.9 0.18 11.6 0.5 3.6 2 1 1 3 3 3 2 Basic region leucine zipper DUF3540 PF12059.3 ESA11314.1 - 0.0098 15.5 0.3 0.0098 15.5 0.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3540) CASP_C PF08172.7 ESA11314.1 - 0.024 13.6 0.7 0.024 13.6 0.5 2.3 2 1 0 2 2 2 0 CASP C terminal DUF904 PF06005.7 ESA11314.1 - 0.033 14.4 2.8 0.033 14.4 2.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Laminin_II PF06009.7 ESA11314.1 - 0.059 13.1 7.2 0.072 12.8 4.6 1.5 1 1 0 1 1 1 0 Laminin Domain II DHC PF09626.5 ESA11314.1 - 0.16 12.6 1.8 0.21 12.2 0.5 1.7 1 1 1 2 2 2 0 Dihaem cytochrome c Tup_N PF08581.5 ESA11314.1 - 0.17 12.1 0.3 0.17 12.1 0.2 2.8 2 1 1 3 3 3 0 Tup N-terminal M PF02370.11 ESA11314.1 - 0.6 10.6 4.9 7.8 7.2 0.3 3.3 2 0 0 2 2 2 0 M protein repeat BRE1 PF08647.6 ESA11314.1 - 0.6 10.1 12.6 0.056 13.4 5.2 1.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TMF_TATA_bd PF12325.3 ESA11314.1 - 0.79 9.4 12.8 0.2 11.3 6.2 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESA11314.1 - 3.1 7.3 12.0 7.4 6.1 8.3 1.7 1 1 0 1 1 1 0 IncA protein DMPK_coil PF08826.5 ESA11314.1 - 3.7 7.5 8.5 0.41 10.5 2.0 2.4 2 1 1 3 3 3 0 DMPK coiled coil domain like FadA PF09403.5 ESA11314.1 - 4.5 7.3 12.2 0.56 10.2 4.0 2.0 1 1 1 2 2 2 0 Adhesion protein FadA DUF4337 PF14235.1 ESA11314.1 - 8.6 6.1 7.3 2.3 8.0 2.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Pox_A_type_inc PF04508.7 ESA11314.1 - 9.8 6.2 9.3 0.33 10.8 0.7 3.1 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat BTB PF00651.26 ESA11315.1 - 5.8e-21 74.5 0.0 1.3e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA11315.1 - 4.1e-07 29.7 2.6 7.2e-06 25.7 0.6 2.9 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA11315.1 - 0.00013 21.2 0.2 0.00019 20.6 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) TLD PF07534.11 ESA11315.1 - 0.00017 21.6 0.4 0.001 19.0 0.0 2.2 2 0 0 2 2 2 1 TLD Podovirus_Gp16 PF05894.7 ESA11316.1 - 0.062 12.6 0.0 0.069 12.4 0.0 1.0 1 0 0 1 1 1 0 Podovirus DNA encapsidation protein (Gp16) APH PF01636.18 ESA11319.1 - 1.8e-19 70.4 0.0 4e-19 69.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 ESA11319.1 - 3.1e-05 23.2 0.2 3.1e-05 23.2 0.1 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase Fructosamin_kin PF03881.9 ESA11319.1 - 0.0008 18.4 0.0 0.051 12.5 0.0 2.3 2 0 0 2 2 2 2 Fructosamine kinase DUF1679 PF07914.6 ESA11319.1 - 0.0012 17.5 2.3 0.0015 17.2 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Ssu72 PF04722.8 ESA11319.1 - 0.077 12.3 0.8 0.29 10.3 0.0 2.3 3 0 0 3 3 3 0 Ssu72-like protein DUF4046 PF13255.1 ESA11320.1 - 0.021 13.5 3.5 0.026 13.2 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4046) Orthopox_A49R PF06489.6 ESA11320.1 - 0.022 14.7 0.4 0.035 14.0 0.3 1.3 1 1 0 1 1 1 0 Orthopoxvirus A49R protein RNA_pol_Rpb5_C PF01191.14 ESA11321.1 - 0.079 12.5 0.1 9.4 5.9 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Cullin_binding PF03556.10 ESA11324.1 - 0.11 12.6 0.7 0.18 11.9 0.1 1.6 1 1 0 1 1 1 0 Cullin binding Methyltransf_11 PF08241.7 ESA11325.1 - 1.6e-12 47.7 0.0 2.7e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA11325.1 - 3.8e-11 43.2 0.0 6e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA11325.1 - 7.6e-10 38.5 0.0 2.7e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA11325.1 - 9.6e-09 35.1 0.0 1.1e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA11325.1 - 9.4e-07 29.4 0.0 4.1e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA11325.1 - 1e-06 28.0 0.0 3e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA11325.1 - 9.9e-06 25.9 0.0 1.6e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA11325.1 - 0.00011 21.6 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA11325.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA11325.1 - 0.0025 16.8 0.0 0.0065 15.5 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase TehB PF03848.9 ESA11325.1 - 0.0037 16.4 0.1 0.0079 15.3 0.1 1.5 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_29 PF03141.11 ESA11325.1 - 0.011 14.0 0.0 0.11 10.8 0.0 1.9 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase FtsJ PF01728.14 ESA11325.1 - 0.023 14.6 0.0 0.069 13.1 0.0 1.7 1 1 1 2 2 2 0 FtsJ-like methyltransferase Sigma_reg_C PF13791.1 ESA11328.1 - 0.05 13.6 0.3 2.5 8.1 0.0 2.2 1 1 1 2 2 2 0 Sigma factor regulator C-terminal MscS_porin PF12795.2 ESA11329.1 - 0.0022 17.3 6.1 0.0022 17.3 4.3 1.5 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain FliH PF02108.11 ESA11329.1 - 0.0037 17.1 1.0 0.0037 17.1 0.7 2.0 2 1 1 3 3 3 1 Flagellar assembly protein FliH FUSC-like PF12805.2 ESA11329.1 - 0.037 12.9 0.9 0.065 12.1 0.6 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF948 PF06103.6 ESA11329.1 - 2.4 8.0 6.8 1.4 8.7 2.4 2.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3136 PF11334.3 ESA11331.1 - 0.025 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) CaM_binding PF07839.6 ESA11331.1 - 0.082 13.1 0.3 0.16 12.1 0.0 1.6 2 0 0 2 2 2 0 Plant calmodulin-binding domain Ubiq-assoc PF09145.5 ESA11331.1 - 0.21 11.4 1.2 0.54 10.1 0.8 1.7 1 0 0 1 1 1 0 Ubiquitin-associated Hyd_WA PF06462.7 ESA11332.1 - 3.8 7.2 6.3 2 8.1 0.0 3.1 4 0 0 4 4 4 0 Propeller Pkinase_Tyr PF07714.12 ESA11335.1 - 1.1e-07 31.2 0.0 1.5e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cu-binding_MopE PF11617.3 ESA11335.1 - 0.0094 15.7 0.5 0.16 11.7 0.0 2.8 3 0 0 3 3 3 1 Protein metal binding site Pkinase PF00069.20 ESA11335.1 - 0.062 12.4 0.0 0.096 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain p450 PF00067.17 ESA11336.1 - 1.8e-33 115.8 0.1 2e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glycos_transf_1 PF00534.15 ESA11337.1 - 1e-24 86.8 0.0 1.5e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 ESA11337.1 - 5.6e-13 49.2 0.0 1.5e-12 47.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESA11337.1 - 0.0001 22.5 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Myosin_tail_1 PF01576.14 ESA11338.1 - 0.013 13.2 4.0 0.013 13.2 2.8 1.0 1 0 0 1 1 1 0 Myosin tail DUF4404 PF14357.1 ESA11338.1 - 0.022 15.1 0.6 0.023 15.0 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Fib_alpha PF08702.5 ESA11338.1 - 0.032 14.3 2.6 0.033 14.3 1.8 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.4 ESA11338.1 - 0.032 14.3 2.4 0.1 12.7 1.7 1.7 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FliD_N PF02465.13 ESA11338.1 - 0.038 14.3 1.1 0.045 14.1 0.7 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus NPV_P10 PF05531.7 ESA11338.1 - 0.047 13.9 1.3 0.084 13.1 0.9 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Glutaredoxin2_C PF04399.8 ESA11338.1 - 0.061 12.9 1.8 0.066 12.8 1.2 1.0 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Peptidase_S74 PF13884.1 ESA11338.1 - 0.066 13.3 1.2 0.091 12.9 0.7 1.6 1 1 0 1 1 1 0 Chaperone of endosialidase DUF3508 PF12018.3 ESA11338.1 - 0.082 11.8 0.7 0.089 11.7 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) YkyA PF10368.4 ESA11338.1 - 0.094 12.0 3.7 0.1 11.9 2.6 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein THOC7 PF05615.8 ESA11338.1 - 0.1 12.8 2.9 0.14 12.4 2.0 1.2 1 1 0 1 1 1 0 Tho complex subunit 7 SH3BP5 PF05276.9 ESA11338.1 - 0.1 11.8 1.9 0.11 11.7 1.3 1.1 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Baculo_PEP_C PF04513.7 ESA11338.1 - 0.11 12.3 1.7 0.11 12.2 1.2 1.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus GldM_C PF12080.3 ESA11338.1 - 0.12 12.2 1.4 0.13 12.1 1.0 1.0 1 0 0 1 1 1 0 GldM C-terminal domain DUF4200 PF13863.1 ESA11338.1 - 0.14 12.1 4.3 0.22 11.4 3.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1351 PF07083.6 ESA11338.1 - 0.16 11.5 4.4 0.19 11.3 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) DUF4456 PF14644.1 ESA11338.1 - 0.16 11.1 1.8 0.69 9.1 1.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4456) DUF1664 PF07889.7 ESA11338.1 - 0.18 11.6 1.7 0.2 11.4 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Ran-binding PF05508.6 ESA11338.1 - 0.2 10.5 1.5 0.21 10.4 1.0 1.1 1 0 0 1 1 1 0 RanGTP-binding protein Spc24 PF08286.6 ESA11338.1 - 0.23 11.1 3.6 0.23 11.1 2.5 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Val_tRNA-synt_C PF10458.4 ESA11338.1 - 0.48 10.5 5.3 0.96 9.5 1.9 2.4 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm V_ATPase_I PF01496.14 ESA11338.1 - 0.58 7.9 2.6 0.6 7.8 1.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.6 ESA11338.1 - 1.3 8.9 5.3 1.9 8.4 1.0 2.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Abhydrolase_3 PF07859.8 ESA11339.1 - 4.5e-37 127.6 0.0 5.4e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA11339.1 - 4.6e-14 51.8 0.0 1.8e-13 49.9 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) Peptidase_S9 PF00326.16 ESA11339.1 - 0.0036 16.5 0.0 0.006 15.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.6 ESA11339.1 - 0.038 13.7 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Pkinase_Tyr PF07714.12 ESA11340.1 - 2e-54 184.4 0.0 2.9e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11340.1 - 4.5e-47 160.3 0.1 7.6e-47 159.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF717 PF05338.7 ESA11340.1 - 0.0019 18.0 0.0 0.0055 16.6 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF717) RIO1 PF01163.17 ESA11340.1 - 0.041 13.2 3.8 0.11 11.8 0.1 2.6 3 0 0 3 3 3 0 RIO1 family APH PF01636.18 ESA11340.1 - 0.066 12.9 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family MFMR PF07777.6 ESA11340.1 - 7.7 6.4 6.1 2.8 7.8 2.1 1.8 2 0 0 2 2 2 0 G-box binding protein MFMR p450 PF00067.17 ESA11341.1 - 1.2e-76 258.1 0.2 1.5e-76 257.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box PF00646.28 ESA11342.1 - 2.3e-05 23.9 0.0 8.3e-05 22.1 0.0 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA11342.1 - 4.5e-05 23.0 0.1 0.00013 21.5 0.1 1.8 1 0 0 1 1 1 1 F-box-like HC2 PF07382.6 ESA11343.1 - 0.001 18.9 8.4 0.0017 18.2 5.8 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 HMG_box PF00505.14 ESA11344.1 - 0.0047 17.1 0.0 0.0073 16.5 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box AAA_12 PF13087.1 ESA11346.1 - 5.7e-19 68.2 0.0 1.1e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA11346.1 - 1.4e-14 54.2 1.8 2.1e-07 30.7 0.0 2.8 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.1 ESA11346.1 - 2.8e-08 33.5 0.0 1.5e-07 31.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA11346.1 - 0.00011 21.9 0.0 0.0013 18.3 0.0 2.3 2 1 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 ESA11346.1 - 0.001 19.2 0.0 0.0037 17.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 ESA11346.1 - 0.0096 15.4 0.5 3.8 6.9 0.0 3.8 3 1 1 4 4 4 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 ESA11346.1 - 0.02 15.0 0.0 0.15 12.2 0.0 2.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1858 PF08984.6 ESA11346.1 - 0.13 11.9 0.0 1.6 8.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1858) AA_permease_2 PF13520.1 ESA11347.1 - 1.5e-43 148.9 22.0 1.5e-43 148.9 15.2 1.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA11347.1 - 1.9e-14 52.9 16.6 1.9e-14 52.9 11.5 2.1 2 0 0 2 2 2 1 Amino acid permease DUF1385 PF07136.6 ESA11347.1 - 1.1 8.2 8.7 0.21 10.6 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1385) Chordopox_A13L PF05961.6 ESA11348.1 - 1.6 8.6 4.6 4.3 7.3 3.2 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Swi5 PF07061.6 ESA11348.1 - 6.7 6.5 10.9 4.5 7.1 3.2 2.5 2 1 0 2 2 2 0 Swi5 Imm45 PF15603.1 ESA11349.1 - 0.45 10.7 4.2 5.3 7.2 0.1 3.2 3 0 0 3 3 3 0 Immunity protein 45 Dimer_Tnp_hAT PF05699.9 ESA11350.1 - 1.4e-17 63.0 0.1 1.5e-17 62.9 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RD3 PF14473.1 ESA11351.1 - 0.18 11.2 3.2 0.89 9.0 0.1 2.5 2 0 0 2 2 2 0 RD3 protein Dimer_Tnp_hAT PF05699.9 ESA11352.1 - 4.1e-05 23.1 0.2 0.00011 21.8 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ubiquitin PF00240.18 ESA11353.1 - 2.8e-14 52.2 0.1 5.1e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA11353.1 - 1.6e-07 30.8 0.3 2.9e-07 30.0 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 ESA11353.1 - 0.025 13.9 0.1 0.043 13.2 0.1 1.3 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ESA11353.1 - 0.042 13.2 0.3 0.096 12.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) FH2 PF02181.18 ESA11354.1 - 1.1e-91 307.5 10.8 1.7e-91 306.9 7.5 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain HsdM_N PF12161.3 ESA11354.1 - 1.1 9.6 13.3 0.17 12.3 1.4 3.2 2 2 3 5 5 5 0 HsdM N-terminal domain HMG_box PF00505.14 ESA11358.1 - 0.015 15.5 0.2 0.029 14.6 0.1 1.6 1 1 0 1 1 1 0 HMG (high mobility group) box Dimer_Tnp_hAT PF05699.9 ESA11359.1 - 7.4e-13 47.9 0.2 8e-13 47.8 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region GATA PF00320.22 ESA11360.1 - 2.4e-12 45.9 6.5 2.4e-12 45.9 4.5 3.4 3 0 0 3 3 3 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 ESA11360.1 - 0.027 13.7 0.6 0.027 13.7 0.4 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding DNA_RNApol_7kD PF03604.8 ESA11360.1 - 0.36 10.3 5.0 4.2 6.9 0.3 3.4 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit FLYWCH PF04500.11 ESA11361.1 - 1.9e-09 37.2 3.0 3e-09 36.6 2.1 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 ESA11361.1 - 4.9e-09 36.2 0.0 1.4e-06 28.3 0.0 3.1 3 0 0 3 3 3 1 MULE transposase domain RNA_pol_Rpb4 PF03874.11 ESA11361.1 - 0.039 13.9 0.8 0.098 12.6 0.4 1.8 1 1 0 1 1 1 0 RNA polymerase Rpb4 DUF1371 PF07115.6 ESA11361.1 - 0.044 13.9 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1371) Meth_synt_1 PF08267.7 ESA11361.1 - 0.076 12.2 0.1 2.3 7.3 0.2 2.2 2 0 0 2 2 2 0 Cobalamin-independent synthase, N-terminal domain Dimer_Tnp_hAT PF05699.9 ESA11362.1 - 4.9e-20 70.9 0.5 5.4e-20 70.8 0.3 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region IMD PF08397.6 ESA11363.1 - 0.068 12.4 0.3 0.073 12.3 0.2 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain Rifin_STEVOR PF02009.11 ESA11363.1 - 0.078 12.6 1.2 0.08 12.5 0.9 1.1 1 0 0 1 1 1 0 Rifin/stevor family DUF1542 PF07564.6 ESA11364.1 - 0.15 12.0 0.9 0.27 11.2 0.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Trypsin PF00089.21 ESA11366.1 - 0.001 18.6 0.0 0.0025 17.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin Lip_prot_lig_C PF10437.4 ESA11366.1 - 0.068 12.8 0.1 0.54 9.9 0.0 2.4 3 0 0 3 3 3 0 Bacterial lipoate protein ligase C-terminus SUKH_6 PF14568.1 ESA11367.1 - 0.036 14.5 1.6 2.8 8.4 0.0 2.5 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall DRP PF06044.7 ESA11368.1 - 0.12 11.3 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Dam-replacing family Pyr_redox_3 PF13738.1 ESA11370.1 - 8e-06 26.0 0.0 7.3e-05 22.9 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA11370.1 - 1.2e-05 25.1 0.0 6.6e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA11370.1 - 0.00065 19.6 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESA11370.1 - 0.008 15.2 0.0 0.018 14.1 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 ESA11370.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESA11370.1 - 0.035 13.0 0.0 0.29 10.0 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.14 ESA11370.1 - 0.11 11.4 0.0 1.1 8.1 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain MNE1 PF13762.1 ESA11371.1 - 0.021 14.9 0.3 0.027 14.5 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component BCS1_N PF08740.6 ESA11372.1 - 0.0015 18.1 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 2 BCS1 N terminal bPH_4 PF06713.6 ESA11372.1 - 0.0032 17.3 1.7 2.2 8.2 0.0 3.5 3 0 0 3 3 3 2 Bacterial PH domain CaMKII_AD PF08332.5 ESA11372.1 - 0.057 13.3 0.0 0.29 11.0 0.0 2.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association DUF3963 PF13124.1 ESA11372.1 - 0.16 11.8 1.5 0.98 9.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3963) DUF148 PF02520.12 ESA11372.1 - 1.7 8.4 5.9 7.4 6.3 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function DUF148 GCC2_GCC3 PF07699.8 ESA11372.1 - 9.4 5.9 18.4 1.3 8.6 0.8 3.6 3 1 1 4 4 4 0 GCC2 and GCC3 Pkinase_Tyr PF07714.12 ESA11373.1 - 3.2e-21 75.5 0.0 7.3e-21 74.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11373.1 - 6e-19 68.1 0.7 1.7e-18 66.7 0.5 1.8 1 0 0 1 1 1 1 Protein kinase domain DUF1059 PF06348.6 ESA11373.1 - 7.3e-07 28.9 0.0 0.35 10.7 0.0 4.8 5 0 0 5 5 5 2 Protein of unknown function (DUF1059) BCS1_N PF08740.6 ESA11373.1 - 0.002 17.7 0.1 0.21 11.1 0.0 2.8 3 0 0 3 3 3 1 BCS1 N terminal HypA PF01155.14 ESA11373.1 - 0.005 16.5 22.5 0.95 9.1 0.2 5.3 5 0 0 5 5 5 3 Hydrogenase expression/synthesis hypA family Zn_Tnp_IS91 PF14319.1 ESA11373.1 - 0.0077 15.7 0.8 0.0077 15.7 0.5 4.9 5 0 0 5 5 5 1 Transposase zinc-binding domain Rap1-DNA-bind PF09197.5 ESA11374.1 - 1.1 9.7 9.7 0.046 14.2 0.9 2.9 3 0 0 3 3 3 0 Rap1, DNA-binding VirE_N PF08800.5 ESA11376.1 - 0.09 12.5 0.2 12 5.6 0.0 2.2 2 0 0 2 2 2 0 VirE N-terminal domain RVT_1 PF00078.22 ESA11379.1 - 6e-07 29.0 0.1 1.3e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase_Tyr PF07714.12 ESA11382.1 - 1.6e-40 138.8 0.6 2.7e-40 138.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11382.1 - 4.2e-32 111.3 0.2 8.1e-32 110.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11382.1 - 4.7e-07 30.2 8.2 9.3e-06 26.1 0.1 3.6 3 0 0 3 3 3 2 Sel1 repeat Snapin_Pallidin PF14712.1 ESA11382.1 - 0.37 11.1 4.5 0.42 10.9 1.0 2.6 3 0 0 3 3 3 0 Snapin/Pallidin RicinB_lectin_2 PF14200.1 ESA11383.1 - 7.1e-05 23.1 1.7 0.00094 19.5 0.4 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like DUF3908 PF13048.1 ESA11383.1 - 0.076 12.9 1.0 0.12 12.3 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3908) UPF0547 PF10571.4 ESA11385.1 - 0.062 13.0 0.6 0.17 11.6 0.4 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-FCS PF06467.9 ESA11385.1 - 0.12 12.0 2.4 0.26 10.9 1.7 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zinc_ribbon_2 PF13240.1 ESA11385.1 - 0.14 11.7 1.7 0.25 10.9 1.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2_2 PF12756.2 ESA11385.1 - 0.23 11.5 3.9 0.42 10.7 2.7 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) STb_secrete PF09075.5 ESA11385.1 - 0.28 11.0 3.4 7 6.5 0.2 2.5 2 0 0 2 2 2 0 Heat-stable enterotoxin B, secretory DUF2218 PF09981.4 ESA11385.1 - 0.64 10.2 2.6 1 9.5 0.6 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2218) WLM PF08325.5 ESA11386.1 - 0.34 10.7 5.4 0.072 12.9 0.5 2.1 2 1 0 2 2 2 0 WLM domain Sel1 PF08238.7 ESA11387.1 - 2.2e-30 104.4 7.0 5.6e-12 45.8 0.2 3.7 4 0 0 4 4 4 3 Sel1 repeat DUF3913 PF13052.1 ESA11387.1 - 0.023 14.6 0.4 0.51 10.3 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3913) TPR_6 PF13174.1 ESA11387.1 - 0.062 13.7 1.1 1.5 9.4 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA11387.1 - 9.8 6.2 8.5 13 5.8 0.2 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat Kelch_3 PF13415.1 ESA11388.1 - 0.039 14.1 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain AA_permease_2 PF13520.1 ESA11390.1 - 0.0003 19.4 0.6 0.0003 19.4 0.4 1.4 1 1 0 1 1 1 1 Amino acid permease DUF202 PF02656.10 ESA11390.1 - 0.0014 18.7 0.1 0.17 12.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) RDD PF06271.7 ESA11390.1 - 0.0063 16.4 1.1 0.017 14.9 0.4 1.8 2 0 0 2 2 2 1 RDD family DUF3098 PF11297.3 ESA11390.1 - 0.036 13.7 0.1 0.07 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) ABC2_membrane_3 PF12698.2 ESA11390.1 - 0.064 12.2 0.2 0.084 11.8 0.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4131 PF13567.1 ESA11390.1 - 0.086 12.2 2.5 0.085 12.2 0.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) UPF0220 PF05255.6 ESA11390.1 - 0.11 11.7 0.3 0.23 10.6 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0220) DUF2157 PF09925.4 ESA11390.1 - 0.45 10.1 2.3 0.48 10.0 0.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) PIRT PF15099.1 ESA11390.1 - 0.54 9.4 2.2 0.87 8.8 0.6 2.1 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family DUF4234 PF14018.1 ESA11390.1 - 0.85 9.4 6.5 0.21 11.3 1.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4234) TLD PF07534.11 ESA11391.1 - 2.3e-11 43.8 1.3 2.9e-11 43.5 0.9 1.1 1 0 0 1 1 1 1 TLD RdRP PF05183.7 ESA11392.1 - 1.1e-16 60.6 0.0 1.5e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF2997 PF11211.3 ESA11394.1 - 0.084 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Exo_endo_phos_2 PF14529.1 ESA11395.1 - 0.0041 16.7 0.1 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase FAM176 PF14851.1 ESA11396.1 - 0.047 13.3 4.2 0.061 12.9 2.9 1.2 1 0 0 1 1 1 0 FAM176 family SPT16 PF08644.6 ESA11399.1 - 0.22 11.3 4.1 0.22 11.3 2.1 1.6 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) RNase_HII PF01351.13 ESA11399.1 - 0.33 10.5 3.4 0.17 11.4 0.3 2.0 1 1 1 2 2 2 0 Ribonuclease HII Methyltransf_11 PF08241.7 ESA11400.1 - 4.9e-10 39.7 0.0 1.1e-09 38.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA11400.1 - 5.7e-09 36.2 0.0 1.1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA11400.1 - 5.4e-08 32.5 1.1 2.6e-07 30.3 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ESA11400.1 - 5.4e-06 26.5 0.0 9e-06 25.7 0.0 1.3 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 ESA11400.1 - 2.3e-05 24.1 0.0 2.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA11400.1 - 2.5e-05 23.4 0.0 3.7e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 ESA11400.1 - 6.2e-05 23.5 0.0 0.00013 22.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA11400.1 - 6.9e-05 22.8 0.0 0.00016 21.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA11400.1 - 7.1e-05 22.2 0.0 0.0001 21.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 ESA11400.1 - 0.0021 17.2 0.0 0.0058 15.7 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA11400.1 - 0.0067 16.8 0.0 0.021 15.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF3747 PF12565.3 ESA11401.1 - 0.066 12.2 0.0 0.066 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3747) Bac_DnaA_C PF08299.6 ESA11402.1 - 0.089 12.6 0.3 3.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix Pkinase_Tyr PF07714.12 ESA11404.1 - 3.9e-05 22.8 0.0 5.8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11404.1 - 0.0094 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF1664 PF07889.7 ESA11405.1 - 0.039 13.7 0.6 0.068 12.9 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Pex24p PF06398.6 ESA11405.1 - 0.051 12.3 10.1 0.033 12.9 3.8 2.0 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin Ribosomal_L5_C PF00673.16 ESA11406.1 - 7.9e-25 86.4 0.0 1.1e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 ESA11406.1 - 2.6e-20 71.9 0.1 1e-19 70.0 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 PPP4R2 PF09184.6 ESA11407.1 - 0.23 10.9 20.1 0.28 10.7 13.9 1.2 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.9 ESA11407.1 - 0.41 8.6 14.6 0.42 8.5 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Striatin PF08232.7 ESA11407.1 - 1.9 8.8 6.2 2.8 8.2 4.3 1.4 1 1 0 1 1 1 0 Striatin family DUF2457 PF10446.4 ESA11407.1 - 2.1 6.9 28.7 2.3 6.8 19.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.7 ESA11407.1 - 4.5 6.8 22.6 5 6.7 15.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.7 ESA11407.1 - 8.7 4.1 24.7 8.9 4.0 17.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3837 PF12939.2 ESA11408.1 - 8.5 6.4 9.5 12 5.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3837) Tropomyosin_1 PF12718.2 ESA11409.1 - 0.004 16.9 10.6 0.0048 16.7 6.8 1.6 1 1 0 1 1 1 1 Tropomyosin like IncA PF04156.9 ESA11409.1 - 0.0043 16.6 8.3 0.0075 15.8 5.8 1.3 1 0 0 1 1 1 1 IncA protein DUF641 PF04859.7 ESA11409.1 - 0.011 15.5 3.6 0.024 14.3 2.5 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Mt_ATP-synt_D PF05873.7 ESA11409.1 - 0.032 13.8 2.0 0.89 9.1 1.2 2.5 2 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Laminin_I PF06008.9 ESA11409.1 - 0.07 12.4 6.7 0.082 12.2 4.1 1.5 1 1 0 1 1 1 0 Laminin Domain I Tox-REase-5 PF15648.1 ESA11409.1 - 0.074 13.3 0.5 0.24 11.7 0.2 1.9 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 5 Atg14 PF10186.4 ESA11409.1 - 0.09 11.6 5.0 0.14 11.0 3.5 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TMPIT PF07851.8 ESA11409.1 - 0.098 11.7 5.1 0.15 11.0 3.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein FliJ PF02050.11 ESA11409.1 - 0.18 11.8 7.8 1.3 9.1 5.4 2.2 1 1 0 1 1 1 0 Flagellar FliJ protein Hemagglutinin PF00509.13 ESA11409.1 - 0.27 9.3 5.2 0.44 8.6 3.0 1.6 1 1 0 1 1 1 0 Haemagglutinin TMF_DNA_bd PF12329.3 ESA11409.1 - 0.29 10.9 14.7 0.053 13.3 5.7 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding CotJB PF12652.2 ESA11409.1 - 0.44 10.6 3.6 6 7.0 0.9 3.2 2 1 1 3 3 3 0 CotJB protein Nsp1_C PF05064.8 ESA11409.1 - 1.5 8.5 8.2 3.5 7.3 5.1 2.0 1 1 1 2 2 2 0 Nsp1-like C-terminal region Fib_alpha PF08702.5 ESA11409.1 - 1.5 8.9 11.8 0.28 11.3 5.0 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Tup_N PF08581.5 ESA11409.1 - 1.6 9.0 10.0 1.1 9.5 4.9 2.3 2 2 0 2 2 2 0 Tup N-terminal Pkinase_Tyr PF07714.12 ESA11413.1 - 2.2e-05 23.6 0.0 4e-05 22.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11413.1 - 0.0098 15.0 0.3 0.021 13.9 0.2 1.5 1 1 0 1 1 1 1 Protein kinase domain GHL13 PF14883.1 ESA11413.1 - 0.046 12.8 0.2 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase family 13 zf-3CxxC PF13695.1 ESA11414.1 - 2.3e-11 43.7 10.1 1.4e-05 25.2 0.1 3.1 2 1 1 3 3 3 2 Zinc-binding domain Pox_A_type_inc PF04508.7 ESA11415.1 - 0.16 11.8 14.1 2.1 8.3 0.8 4.4 3 1 1 4 4 4 0 Viral A-type inclusion protein repeat DUF619 PF04768.8 ESA11416.1 - 3.3e-50 169.8 0.7 3.3e-50 169.8 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 ESA11416.1 - 3.2e-30 104.9 0.0 7.5e-30 103.7 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 ESA11416.1 - 2.7e-22 79.5 0.0 5.2e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.15 ESA11416.1 - 0.0063 16.4 0.0 0.019 14.8 0.0 1.9 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 ESA11416.1 - 0.1 13.1 0.0 0.28 11.7 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ATP-synt_F PF01990.12 ESA11417.1 - 3.5e-31 107.4 0.2 4e-31 107.2 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.1 ESA11417.1 - 0.039 12.8 0.0 0.041 12.8 0.0 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Pkinase_Tyr PF07714.12 ESA11418.1 - 0.00019 20.6 0.0 0.00033 19.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NYN PF01936.13 ESA11421.1 - 0.014 15.6 0.0 0.015 15.5 0.0 1.1 1 0 0 1 1 1 0 NYN domain Pkinase_Tyr PF07714.12 ESA11422.1 - 5.6e-17 61.6 0.0 8.4e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11422.1 - 6.6e-16 58.2 0.0 1.2e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FBA_2 PF07735.12 ESA11422.1 - 0.22 11.4 0.0 0.22 11.4 0.0 3.3 2 1 1 3 3 3 0 F-box associated FKS1_dom1 PF14288.1 ESA11425.1 - 0.27 11.1 4.3 0.12 12.2 1.3 1.7 2 0 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 ICA69 PF04629.9 ESA11425.1 - 0.48 10.3 3.2 1 9.2 0.1 2.0 2 0 0 2 2 2 0 Islet cell autoantigen ICA69, C-terminal domain DUF544 PF04424.8 ESA11429.1 - 7.3e-28 96.8 0.9 1.8e-21 76.1 0.5 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF544) PQ-loop PF04193.9 ESA11430.1 - 7e-37 124.7 12.8 2.3e-20 71.9 2.3 3.5 4 0 0 4 4 4 2 PQ loop repeat YrhC PF14143.1 ESA11430.1 - 0.044 13.7 0.4 0.43 10.5 0.1 2.7 2 0 0 2 2 2 0 YrhC-like protein ASFV_J13L PF05568.6 ESA11430.1 - 0.055 13.0 0.6 0.055 13.0 0.4 1.6 2 0 0 2 2 2 0 African swine fever virus J13L protein TMEM154 PF15102.1 ESA11430.1 - 1.8 8.2 3.8 1.8 8.2 1.3 1.8 1 1 1 2 2 2 0 TMEM154 protein family LSM PF01423.17 ESA11431.1 - 1.1e-17 63.3 1.4 1.2e-17 63.2 1.0 1.0 1 0 0 1 1 1 1 LSM domain PhnA PF03831.9 ESA11431.1 - 0.067 12.6 0.1 0.27 10.6 0.0 1.9 2 0 0 2 2 2 0 PhnA protein Hpr_kinase_N PF02603.11 ESA11432.1 - 0.014 15.0 0.2 0.096 12.3 0.0 2.2 1 1 1 2 2 2 0 HPr Serine kinase N terminus DUF1523 PF07509.6 ESA11435.1 - 0.12 11.5 0.0 0.13 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) TcdB_N PF12918.2 ESA11436.1 - 0.021 14.9 2.0 0.026 14.5 1.4 1.2 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain DUF3600 PF12207.3 ESA11436.1 - 0.063 12.8 0.1 0.072 12.6 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3600) BTB PF00651.26 ESA11437.1 - 2.6e-17 62.7 0.4 8.4e-17 61.1 0.0 2.0 2 1 1 3 3 3 1 BTB/POZ domain eIF_4G1 PF12152.3 ESA11437.1 - 0.009 15.8 0.8 4.2 7.3 0.0 3.1 3 0 0 3 3 3 2 Eukaryotic translation initiation factor 4G1 DUF497 PF04365.8 ESA11438.1 - 0.11 12.3 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF497) TLD PF07534.11 ESA11440.1 - 1.9e-12 47.3 1.8 1.9e-12 47.3 1.2 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA11440.1 - 0.00087 19.0 0.4 0.0022 17.8 0.3 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF3942 PF13078.1 ESA11440.1 - 0.23 11.5 5.2 0.054 13.6 0.7 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3942) PTPA PF03095.10 ESA11441.1 - 8.8e-91 304.1 1.2 9.7e-91 304.0 0.9 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pkinase_Tyr PF07714.12 ESA11442.1 - 4.6e-40 137.3 0.5 4.6e-40 137.3 0.3 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11442.1 - 7.5e-39 133.4 0.7 1.6e-38 132.3 0.5 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11442.1 - 1.7e-17 63.4 0.4 1.6e-07 31.7 0.0 3.9 3 0 0 3 3 3 2 Sel1 repeat Kinase-like PF14531.1 ESA11442.1 - 0.012 14.5 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like zf-C2H2 PF00096.21 ESA11443.1 - 2.3e-15 55.8 25.8 7e-06 26.0 1.2 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA11443.1 - 1.6e-14 53.3 14.0 2e-08 34.0 2.0 4.1 3 1 2 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA11443.1 - 2.8e-09 36.6 23.8 0.0019 18.4 1.0 3.2 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.2 ESA11443.1 - 0.0025 17.9 0.4 0.0025 17.9 0.3 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA11443.1 - 0.022 14.6 0.1 0.022 14.6 0.1 2.8 3 1 0 3 3 3 0 C2H2-type zinc finger GAGA PF09237.6 ESA11443.1 - 0.022 14.3 3.1 0.49 10.0 1.2 2.3 1 1 1 2 2 2 0 GAGA factor RPAP2_Rtr1 PF04181.8 ESA11443.1 - 0.17 11.9 4.6 2 8.5 0.1 2.4 1 1 1 2 2 2 0 Rtr1/RPAP2 family zf-C2H2_jaz PF12171.3 ESA11443.1 - 0.26 11.4 0.2 0.26 11.4 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding C1_4 PF07975.7 ESA11443.1 - 1.2 9.2 7.8 0.62 10.1 2.1 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain CHORD PF04968.7 ESA11443.1 - 3.1 8.1 13.1 1.6 9.0 1.3 2.9 1 1 2 3 3 3 0 CHORD RRM_1 PF00076.17 ESA11444.1 - 2.3e-13 49.5 0.1 3.2e-13 49.1 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA11444.1 - 7.9e-11 41.7 0.0 1.1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA11444.1 - 2e-05 24.3 0.1 3.2e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_pol_Rpb4 PF03874.11 ESA11444.1 - 0.069 13.1 0.2 0.14 12.1 0.1 1.5 2 0 0 2 2 2 0 RNA polymerase Rpb4 zf-DHHC PF01529.15 ESA11446.1 - 1.1e-31 109.6 10.8 1.1e-31 109.6 7.5 1.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF1272 PF06906.6 ESA11446.1 - 0.078 12.8 2.0 0.13 12.1 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Ceramidase PF05875.7 ESA11447.1 - 1.3e-18 67.1 5.7 1.5e-18 66.8 4.0 1.1 1 0 0 1 1 1 1 Ceramidase Acyl_transf_3 PF01757.17 ESA11447.1 - 0.014 14.2 7.0 0.017 14.0 4.9 1.1 1 0 0 1 1 1 0 Acyltransferase family DUF998 PF06197.8 ESA11447.1 - 0.058 12.7 3.1 0.47 9.7 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF998) CcmH PF03918.9 ESA11447.1 - 0.19 10.7 0.9 1.4 7.8 0.4 2.4 3 0 0 3 3 3 0 Cytochrome C biogenesis protein AA_permease_2 PF13520.1 ESA11448.1 - 1e-40 139.5 42.3 1e-40 139.5 29.3 1.4 2 0 0 2 2 2 1 Amino acid permease DUF4381 PF14316.1 ESA11448.1 - 0.011 15.8 1.5 0.65 10.0 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Neurensin PF14927.1 ESA11448.1 - 0.056 12.8 0.0 0.34 10.2 0.0 2.4 1 0 0 1 1 1 0 Neurensin FixQ PF05545.6 ESA11449.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ PAN_3 PF08277.7 ESA11449.1 - 0.15 11.6 0.5 0.26 10.9 0.4 1.4 1 0 0 1 1 1 0 PAN-like domain DUF613 PF04764.7 ESA11450.1 - 0.02 14.8 0.1 0.06 13.2 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF613) CagE_TrbE_VirB PF03135.9 ESA11450.1 - 0.059 13.1 0.6 0.075 12.7 0.4 1.1 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system DUF1919 PF08942.5 ESA11450.1 - 0.092 12.0 1.5 0.17 11.2 0.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1919) HhH-GPD PF00730.20 ESA11451.1 - 0.024 14.9 0.2 1.1 9.5 0.0 3.5 3 0 0 3 3 3 0 HhH-GPD superfamily base excision DNA repair protein Wzy_C PF04932.10 ESA11451.1 - 0.031 14.0 2.2 0.17 11.6 0.2 2.4 2 0 0 2 2 2 0 O-Antigen ligase TraG_N PF07916.6 ESA11451.1 - 0.1 10.9 0.1 0.38 9.1 0.0 1.6 1 1 0 2 2 2 0 TraG-like protein, N-terminal region GCD14 PF08704.5 ESA11452.1 - 0.025 14.1 0.1 0.028 13.9 0.1 1.0 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit YaaC PF14175.1 ESA11452.1 - 0.076 11.9 0.6 0.082 11.8 0.4 1.0 1 0 0 1 1 1 0 YaaC-like Protein zf-BED PF02892.10 ESA11453.1 - 1e-09 37.9 3.1 1e-09 37.9 2.1 2.4 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA11453.1 - 0.021 15.1 0.6 0.073 13.4 0.1 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Saf-Nte_pilin PF09460.5 ESA11453.1 - 0.077 12.7 1.4 9.2 6.0 0.5 2.3 2 1 0 2 2 2 0 Saf-pilin pilus formation protein Pkinase PF00069.20 ESA11454.1 - 4.8e-28 98.0 0.0 6.9e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11454.1 - 3.9e-27 94.9 0.0 5.3e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase GBP_C PF02841.9 ESA11455.1 - 0.017 14.2 2.7 0.028 13.6 1.9 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Glug PF07581.7 ESA11456.1 - 0.014 15.5 0.5 0.026 14.7 0.4 1.5 1 0 0 1 1 1 0 The GLUG motif Lipoprotein_21 PF14041.1 ESA11456.1 - 0.11 12.4 0.1 0.23 11.4 0.0 1.5 1 1 0 1 1 1 0 LppP/LprE lipoprotein PHD PF00628.24 ESA11458.1 - 7e-12 44.8 8.5 1.1e-11 44.2 5.9 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.1 ESA11458.1 - 0.035 14.1 1.3 0.064 13.2 0.9 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain DUF4451 PF14616.1 ESA11458.1 - 0.051 13.3 4.3 0.14 11.9 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) zf-HIT PF04438.11 ESA11458.1 - 0.1 12.2 2.9 8.4 6.1 0.2 2.4 2 0 0 2 2 2 0 HIT zinc finger PHD_2 PF13831.1 ESA11458.1 - 0.34 10.2 3.3 0.72 9.2 2.3 1.5 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.17 ESA11458.1 - 1.1 9.0 6.5 0.15 11.8 1.3 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2296 PF10058.4 ESA11458.1 - 6.8 6.5 7.4 15 5.4 5.1 1.5 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) DUF908 PF06012.7 ESA11459.1 - 0.14 11.4 5.2 0.18 11.0 3.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) FAST_1 PF06743.10 ESA11460.1 - 0.12 12.1 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 Protamine_P1 PF00260.15 ESA11460.1 - 0.3 10.9 15.4 0.38 10.5 10.7 1.1 1 0 0 1 1 1 0 Protamine P1 TT_ORF1 PF02956.9 ESA11460.1 - 2.9 6.2 8.7 3 6.1 6.0 1.0 1 0 0 1 1 1 0 TT viral orf 1 L27_2 PF09045.5 ESA11461.1 - 0.12 11.9 0.2 0.2 11.1 0.2 1.4 1 0 0 1 1 1 0 L27_2 Myb_DNA-binding PF00249.26 ESA11463.1 - 0.0031 17.5 0.0 0.0073 16.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA11463.1 - 0.0061 17.1 0.1 0.026 15.1 0.0 2.0 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Homeobox PF00046.24 ESA11464.1 - 3e-10 39.5 0.1 1.3e-09 37.5 0.1 2.2 1 0 0 1 1 1 1 Homeobox domain CBS PF00571.23 ESA11465.1 - 4.1e-25 87.2 5.1 3.2e-09 36.4 0.0 4.6 4 1 0 4 4 4 4 CBS domain NAD_kinase PF01513.16 ESA11465.1 - 0.0098 14.6 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase Anticodon_1 PF08264.8 ESA11466.1 - 2.7e-05 23.9 2.9 0.04 13.6 0.0 2.2 1 1 1 2 2 2 2 Anticodon-binding domain of tRNA tRNA-synt_1b PF00579.20 ESA11467.1 - 0.035 13.2 0.1 0.035 13.2 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) DUF221 PF02714.10 ESA11470.1 - 5.2e-83 278.5 21.9 1.1e-82 277.4 15.1 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ESA11470.1 - 6.1e-37 126.5 0.6 6.1e-37 126.5 0.4 3.1 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ESA11470.1 - 1.8e-17 63.6 0.0 1.8e-17 63.6 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4463) BTB PF00651.26 ESA11471.1 - 2.6e-17 62.8 0.4 7.3e-17 61.3 0.3 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA11471.1 - 2.4e-12 46.9 1.3 4.5e-12 46.1 0.3 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA11471.1 - 0.0014 18.4 0.5 0.0043 16.8 0.1 2.1 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF3850 PF12961.2 ESA11471.1 - 0.5 10.3 6.7 0.44 10.5 0.1 3.7 3 1 1 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3850) Cytochrome_C7 PF14522.1 ESA11474.1 - 0.52 9.9 5.6 0.21 11.2 2.1 1.7 2 1 0 2 2 2 0 Cytochrome c7 Cytochrom_c3_2 PF14537.1 ESA11474.1 - 1.9 8.8 6.1 3.2 8.1 2.9 2.0 1 1 0 1 1 1 0 Cytochrome c3 BTB PF00651.26 ESA11475.1 - 6.7e-15 55.0 0.3 2e-14 53.5 0.2 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA11475.1 - 1.3e-12 47.8 1.5 1.3e-12 47.8 1.1 2.9 3 1 0 3 3 3 1 TLD BTB_2 PF02214.17 ESA11475.1 - 1e-09 38.4 1.7 3.7e-07 30.2 0.1 3.6 2 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA11475.1 - 2.4e-07 30.5 0.6 3e-06 27.0 0.4 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch Jiraiya PF15038.1 ESA11477.1 - 0.031 13.6 0.0 0.032 13.6 0.0 1.0 1 0 0 1 1 1 0 Jiraiya CRPV_capsid PF08762.5 ESA11477.1 - 0.046 13.1 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 CRPV capsid protein like MULE PF10551.4 ESA11478.1 - 0.00028 20.9 0.2 0.00055 20.0 0.1 1.6 1 1 0 1 1 1 1 MULE transposase domain DUF1955 PF09205.5 ESA11478.1 - 0.016 14.7 0.1 0.032 13.7 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1955) UPF0302 PF08864.5 ESA11478.1 - 0.036 13.8 0.3 0.049 13.4 0.2 1.3 1 0 0 1 1 1 0 UPF0302 domain VP4_haemagglut PF00426.13 ESA11479.1 - 0.00014 20.0 0.1 0.00017 19.7 0.1 1.0 1 0 0 1 1 1 1 Outer Capsid protein VP4 (Hemagglutinin) DUF4208 PF13907.1 ESA11479.1 - 0.055 13.6 0.7 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Methyltrans_RNA PF04452.9 ESA11479.1 - 0.065 12.3 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA methyltransferase TLD PF07534.11 ESA11482.1 - 2.9e-12 46.7 1.5 3.8e-12 46.3 1.0 1.2 1 0 0 1 1 1 1 TLD zf-BED PF02892.10 ESA11483.1 - 0.0015 18.2 7.1 0.013 15.2 4.9 2.3 1 1 0 1 1 1 1 BED zinc finger PBP1_TM PF14812.1 ESA11483.1 - 7.2 7.0 6.7 1.1 9.5 1.5 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-CDGSH PF09360.5 ESA11484.1 - 0.062 13.1 0.3 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 Iron-binding zinc finger CDGSH type AKAP_110 PF05716.8 ESA11486.1 - 0.017 13.1 0.2 0.02 12.9 0.1 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) DUF2833 PF11090.3 ESA11488.1 - 0.077 13.1 0.2 0.12 12.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2833) Cu-oxidase_3 PF07732.10 ESA11490.1 - 3.4e-35 120.3 3.1 5.1e-35 119.7 2.2 1.3 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.17 ESA11490.1 - 0.011 15.6 0.4 0.086 12.7 0.0 2.1 2 0 0 2 2 2 0 Multicopper oxidase Tox-GHH PF15636.1 ESA11490.1 - 0.03 13.9 0.0 0.092 12.3 0.0 1.8 2 0 0 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin Cu-oxidase_2 PF07731.9 ESA11490.1 - 0.075 12.5 3.0 1 8.8 2.0 2.1 1 1 0 1 1 1 0 Multicopper oxidase Reo_sigmaC PF04582.7 ESA11491.1 - 2.3e-05 23.7 1.3 2.5e-05 23.6 0.9 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 ESA11491.1 - 0.00077 17.3 2.0 0.001 16.9 1.4 1.0 1 0 0 1 1 1 1 Myosin tail DHC_N1 PF08385.7 ESA11491.1 - 0.0019 16.6 1.8 0.0026 16.2 1.2 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Tropomyosin PF00261.15 ESA11491.1 - 0.0057 15.7 1.7 0.0082 15.2 1.2 1.2 1 0 0 1 1 1 1 Tropomyosin TBPIP PF07106.8 ESA11491.1 - 0.0081 15.7 6.7 0.012 15.1 4.6 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fmp27_WPPW PF10359.4 ESA11491.1 - 0.012 14.0 3.3 0.013 13.9 2.3 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2951 PF11166.3 ESA11491.1 - 0.017 14.9 4.6 0.45 10.3 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) V_ATPase_I PF01496.14 ESA11491.1 - 0.018 12.9 2.1 0.021 12.7 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.7 ESA11491.1 - 0.018 14.8 5.7 0.03 14.1 3.9 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_I PF06008.9 ESA11491.1 - 0.018 14.3 8.6 0.024 13.9 6.0 1.1 1 0 0 1 1 1 0 Laminin Domain I DUF677 PF05055.7 ESA11491.1 - 0.036 12.7 0.7 0.047 12.3 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) PspA_IM30 PF04012.7 ESA11491.1 - 0.039 13.3 4.1 0.21 10.9 2.8 1.9 1 1 0 1 1 1 0 PspA/IM30 family MscS_porin PF12795.2 ESA11491.1 - 0.04 13.2 8.1 0.051 12.8 5.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CCDC155 PF14662.1 ESA11491.1 - 0.046 13.3 3.3 0.078 12.5 2.3 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 zf-C4H2 PF10146.4 ESA11491.1 - 0.053 13.5 1.4 0.057 13.4 0.9 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein APG6 PF04111.7 ESA11491.1 - 0.058 12.4 3.4 0.071 12.1 2.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 NPV_P10 PF05531.7 ESA11491.1 - 0.09 13.0 6.2 0.56 10.4 4.3 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein IncA PF04156.9 ESA11491.1 - 0.093 12.3 4.0 0.14 11.7 2.8 1.2 1 0 0 1 1 1 0 IncA protein DAHP_synth_2 PF01474.11 ESA11491.1 - 0.097 11.0 2.2 0.12 10.6 1.5 1.1 1 0 0 1 1 1 0 Class-II DAHP synthetase family Vps5 PF09325.5 ESA11491.1 - 0.15 11.3 2.5 0.23 10.7 1.7 1.2 1 0 0 1 1 1 0 Vps5 C terminal like MCPsignal PF00015.16 ESA11491.1 - 0.16 11.5 4.9 0.25 10.8 3.4 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.6 ESA11491.1 - 0.18 11.7 3.4 0.64 9.9 0.3 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.3 ESA11491.1 - 0.19 11.4 4.5 0.29 10.8 3.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.6 ESA11491.1 - 0.2 10.2 8.0 0.52 8.9 5.6 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Nsp1_C PF05064.8 ESA11491.1 - 0.21 11.2 3.7 0.34 10.5 2.6 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region TMPIT PF07851.8 ESA11491.1 - 0.23 10.4 3.5 0.28 10.2 2.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein Vps53_N PF04100.7 ESA11491.1 - 0.27 9.9 5.5 0.33 9.6 3.8 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal DUF2959 PF11172.3 ESA11491.1 - 0.27 10.9 3.3 0.45 10.2 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) Blo-t-5 PF11642.3 ESA11491.1 - 0.31 10.7 2.1 0.45 10.2 0.5 1.9 1 1 1 2 2 2 0 Mite allergen Blo t 5 CENP-Q PF13094.1 ESA11491.1 - 0.36 10.8 6.7 1.1 9.2 4.6 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FliJ PF02050.11 ESA11491.1 - 0.4 10.7 6.8 0.7 9.9 4.3 1.7 1 1 0 1 1 1 0 Flagellar FliJ protein DUF342 PF03961.8 ESA11491.1 - 0.4 9.0 5.1 0.46 8.8 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ACCA PF03255.9 ESA11491.1 - 0.53 9.8 2.6 1.5 8.3 1.8 1.8 1 1 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Prefoldin PF02996.12 ESA11491.1 - 0.66 9.6 5.0 3.7 7.2 0.5 2.2 1 1 2 3 3 3 0 Prefoldin subunit BRE1 PF08647.6 ESA11491.1 - 0.76 9.7 4.7 1.9 8.5 3.2 1.7 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase DivIC PF04977.10 ESA11491.1 - 0.98 8.9 6.1 3 7.4 0.9 2.2 1 1 1 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.3 ESA11491.1 - 0.99 9.2 5.9 3 7.7 0.7 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding HsbA PF12296.3 ESA11491.1 - 0.99 9.2 6.6 2.3 8.1 0.4 2.3 1 1 1 2 2 2 0 Hydrophobic surface binding protein A DUF904 PF06005.7 ESA11491.1 - 1.1 9.5 7.3 0.14 12.4 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) L31 PF09784.4 ESA11491.1 - 1.2 9.2 3.6 18 5.4 0.2 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L31 YlqD PF11068.3 ESA11491.1 - 1.4 8.9 6.8 2.6 8.0 4.7 1.6 1 1 0 1 1 1 0 YlqD protein Sas10_Utp3 PF04000.10 ESA11491.1 - 1.8 8.7 4.9 3.9 7.7 0.6 2.4 1 1 1 2 2 2 0 Sas10/Utp3/C1D family SlyX PF04102.7 ESA11491.1 - 2.6 8.4 8.1 2.3 8.6 0.9 2.3 1 1 0 2 2 2 0 SlyX Muted PF14942.1 ESA11491.1 - 3.5 7.4 6.0 4.5 7.1 0.8 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DUF972 PF06156.8 ESA11491.1 - 5.2 7.4 5.7 35 4.8 3.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF16 PF01519.11 ESA11491.1 - 5.3 7.3 7.0 0.99 9.6 1.2 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 FlxA PF14282.1 ESA11491.1 - 7.3 6.5 15.9 2.2e+02 1.8 11.0 2.5 1 1 0 1 1 1 0 FlxA-like protein bZIP_2 PF07716.10 ESA11491.1 - 8.7 6.2 7.8 1.7 8.4 1.4 2.2 2 0 0 2 2 2 0 Basic region leucine zipper Syntaxin PF00804.20 ESA11491.1 - 9 6.5 10.0 23 5.2 7.0 1.7 1 1 0 1 1 1 0 Syntaxin PQQ_2 PF13360.1 ESA11492.1 - 1.7e-06 27.7 0.6 3.2e-05 23.5 0.2 2.2 2 0 0 2 2 2 1 PQQ-like domain DUF4468 PF14730.1 ESA11492.1 - 0.065 12.9 0.2 0.68 9.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold Zip PF02535.17 ESA11493.1 - 1.3 8.0 8.6 3 6.7 6.0 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter GvpD PF07088.6 ESA11494.1 - 0.081 11.2 1.9 0.11 10.7 1.3 1.1 1 0 0 1 1 1 0 GvpD gas vesicle protein Use1 PF09753.4 ESA11494.1 - 3.4 7.0 17.2 0.37 10.1 8.8 1.6 2 0 0 2 2 2 0 Membrane fusion protein Use1 Sel1 PF08238.7 ESA11498.1 - 4.3e-133 430.8 86.5 2.2e-13 50.3 0.1 12.0 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA11498.1 - 6.9e-14 51.2 53.3 0.26 11.8 0.4 11.9 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11498.1 - 9.5e-10 37.9 35.6 2.6 8.4 0.1 12.4 12 0 0 12 12 12 3 Tetratricopeptide repeat MIT PF04212.13 ESA11498.1 - 3.1e-06 26.9 56.5 1 9.2 0.1 11.5 12 0 0 12 12 12 7 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA11498.1 - 0.00096 18.8 22.6 38 4.1 0.0 10.2 12 0 0 12 12 12 0 Lung surfactant protein D coiled-coil trimerisation TPR_20 PF14561.1 ESA11498.1 - 0.012 15.6 9.2 12 6.0 0.1 6.1 3 1 3 7 7 7 0 Tetratricopeptide repeat Foie-gras_1 PF11817.3 ESA11498.1 - 0.034 13.6 21.9 3.2 7.1 1.3 5.5 1 1 2 3 3 3 0 Foie gras liver health family 1 Erythrovirus_X PF06795.6 ESA11498.1 - 0.43 10.6 6.0 8.6 6.4 0.1 5.6 3 1 5 9 9 9 0 Erythrovirus X protein DDE_1 PF03184.14 ESA11502.1 - 2.4e-21 75.8 0.0 2.7e-21 75.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease peroxidase PF00141.18 ESA11504.1 - 9.9e-51 172.4 0.0 1.5e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Peroxidase F-box-like PF12937.2 ESA11506.1 - 0.00052 19.6 0.1 0.00085 18.9 0.0 1.4 1 0 0 1 1 1 1 F-box-like Polysacc_synt PF01943.12 ESA11508.1 - 0.0086 15.3 0.1 0.0092 15.2 0.1 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Pox_H7 PF04787.7 ESA11510.1 - 0.0052 16.5 1.0 0.011 15.5 0.7 1.5 1 0 0 1 1 1 1 Late protein H7 TRAPPC-Trs85 PF12739.2 ESA11510.1 - 0.1 11.2 0.2 0.13 10.9 0.1 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Grp1_Fun34_YaaH PF01184.14 ESA11511.1 - 5.3e-49 166.3 17.4 6.6e-49 166.0 12.0 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Pkinase_Tyr PF07714.12 ESA11512.1 - 1.6e-39 135.5 0.0 9.7e-22 77.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA11512.1 - 2.6e-39 134.9 0.1 1.3e-19 70.3 0.2 2.5 2 0 0 2 2 2 2 Protein kinase domain Ras PF00071.17 ESA11512.1 - 7.7e-36 122.9 0.0 1.5e-35 122.0 0.0 1.5 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA11512.1 - 9.1e-11 42.2 0.0 2.3e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 ESA11512.1 - 0.00034 20.0 0.0 0.0052 16.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain 7tm_1 PF00001.16 ESA11513.1 - 9.1e-09 34.8 11.8 1.1e-08 34.4 5.2 2.2 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) FAR1 PF03101.10 ESA11514.1 - 8.5e-09 35.8 2.4 1.8e-08 34.7 1.7 1.6 1 0 0 1 1 1 1 FAR1 DNA-binding domain MULE PF10551.4 ESA11514.1 - 0.036 14.2 0.1 0.27 11.4 0.0 2.4 2 0 0 2 2 2 0 MULE transposase domain HMG_box PF00505.14 ESA11516.1 - 7.1e-16 58.2 2.0 1.3e-15 57.3 1.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA11516.1 - 0.013 15.8 0.8 0.024 14.9 0.6 1.5 1 0 0 1 1 1 0 HMG-box domain Aldo_ket_red PF00248.16 ESA11517.1 - 0.0002 20.2 0.1 0.00023 20.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glucosamine_iso PF01182.15 ESA11518.1 - 2.7e-22 79.4 0.0 4e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Exo_endo_phos PF03372.18 ESA11520.1 - 9.2e-09 35.5 0.1 1.6e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA11520.1 - 0.00015 21.3 1.4 0.00032 20.3 0.1 2.2 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase DUF4077 PF13295.1 ESA11521.1 - 0.035 13.8 0.2 0.038 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4077) HMG_box PF00505.14 ESA11522.1 - 9.1e-09 35.4 2.0 1.8e-08 34.5 1.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box MRP-S28 PF10213.4 ESA11522.1 - 0.046 13.8 0.1 0.058 13.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein DUF3693 PF12472.3 ESA11522.1 - 0.11 12.0 1.3 0.22 11.1 0.9 1.4 1 0 0 1 1 1 0 Phage related protein RRM_3 PF08777.6 ESA11522.1 - 0.13 12.1 0.2 0.19 11.6 0.2 1.3 1 0 0 1 1 1 0 RNA binding motif Pro_CA PF00484.14 ESA11523.1 - 2.6e-48 163.8 0.2 3.1e-48 163.6 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase LisH PF08513.6 ESA11525.1 - 0.042 13.6 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 LisH Neur_chan_memb PF02932.11 ESA11525.1 - 0.17 11.7 1.8 0.22 11.3 1.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GAPT PF11770.3 ESA11525.1 - 1.4 8.6 5.8 1.9 8.1 4.0 1.2 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Orbi_VP6 PF01516.11 ESA11525.1 - 1.8 7.5 11.6 2.4 7.1 8.0 1.1 1 0 0 1 1 1 0 Orbivirus helicase VP6 DUF2031 PF09592.5 ESA11525.1 - 6.9 5.7 14.1 8.5 5.4 9.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2031) DUF3942 PF13078.1 ESA11527.1 - 0.24 11.4 6.1 0.57 10.2 3.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3942) Chondroitinas_B PF14592.1 ESA11528.1 - 0.0061 15.4 0.3 0.0083 14.9 0.2 1.1 1 0 0 1 1 1 1 Chondroitinase B Phage_H_T_join PF05521.6 ESA11528.1 - 0.1 12.8 0.1 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Phage head-tail joining protein E1_DerP2_DerF2 PF02221.10 ESA11529.1 - 7.1e-08 32.7 0.3 9e-08 32.4 0.2 1.1 1 0 0 1 1 1 1 ML domain Phage_Treg PF04761.7 ESA11529.1 - 0.025 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator E1_DerP2_DerF2 PF02221.10 ESA11530.1 - 0.0053 17.0 0.1 0.0063 16.7 0.1 1.2 1 0 0 1 1 1 1 ML domain DUF717 PF05338.7 ESA11531.1 - 0.064 13.2 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF717) zf-RanBP PF00641.13 ESA11531.1 - 0.5 9.5 2.7 0.85 8.7 0.5 2.4 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others PP2C PF00481.16 ESA11532.1 - 5.1e-60 203.0 0.1 6.6e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESA11532.1 - 0.00011 21.7 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C RRM_2 PF04059.7 ESA11532.1 - 0.033 14.1 1.2 5 7.1 0.2 2.4 2 0 0 2 2 2 0 RNA recognition motif 2 Cys_rich_FGFR PF00839.12 ESA11532.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Cysteine rich repeat RRM_1 PF00076.17 ESA11534.1 - 9.5e-24 82.8 0.1 4.5e-10 39.0 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA11534.1 - 2.5e-18 65.7 0.0 3.7e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA11534.1 - 5.6e-13 48.5 0.0 2.3e-05 24.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M1 PF01433.15 ESA11535.1 - 4.3e-132 440.8 3.0 1.1e-131 439.6 2.1 1.6 1 1 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 ESA11535.1 - 5.1e-71 239.5 0.5 9.9e-71 238.6 0.1 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 ESA11535.1 - 1.7e-19 70.1 0.5 3.5e-19 69.1 0.4 1.5 1 0 0 1 1 1 1 Peptidase MA superfamily BCNT PF07572.7 ESA11536.1 - 9e-24 83.2 5.4 9e-24 83.2 3.7 2.5 3 0 0 3 3 3 1 Bucentaur or craniofacial development DUF659 PF04937.10 ESA11537.1 - 9.1e-08 31.7 0.3 9.1e-08 31.7 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) DUF4413 PF14372.1 ESA11537.1 - 0.00065 19.6 0.8 0.049 13.6 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4413) zf-BED PF02892.10 ESA11538.1 - 8.5e-06 25.4 0.9 1.5e-05 24.6 0.6 1.4 1 0 0 1 1 1 1 BED zinc finger HutD PF05962.6 ESA11538.1 - 0.04 13.6 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 HutD Flu_M1_C PF08289.6 ESA11538.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain TLD PF07534.11 ESA11540.1 - 1.3e-13 51.1 1.9 1.3e-13 51.1 1.3 1.7 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA11540.1 - 1.6e-10 40.9 0.3 4.8e-10 39.3 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA11540.1 - 2.1e-06 27.5 1.2 0.00056 19.7 0.1 3.8 3 1 0 3 3 3 1 BTB And C-terminal Kelch BCS1_N PF08740.6 ESA11542.1 - 1.8e-07 30.9 0.0 0.00085 18.9 0.0 2.7 3 0 0 3 3 3 2 BCS1 N terminal KTI12 PF08433.5 ESA11542.1 - 0.0018 17.5 0.3 0.006 15.8 0.0 2.0 2 0 0 2 2 2 1 Chromatin associated protein KTI12 NOB1_Zn_bind PF08772.6 ESA11542.1 - 0.034 13.9 1.2 0.034 13.9 0.8 3.7 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like DUF4413 PF14372.1 ESA11542.1 - 0.097 12.6 2.6 23 5.0 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) SRP9-21 PF05486.7 ESA11542.1 - 0.6 9.8 3.7 15 5.4 0.1 3.2 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) DZR PF12773.2 ESA11542.1 - 5.5 6.8 13.8 4.8 7.0 0.1 3.4 3 0 0 3 3 3 0 Double zinc ribbon ETC_C1_NDUFA5 PF04716.9 ESA11543.1 - 0.043 13.3 0.0 0.084 12.4 0.0 1.5 1 0 0 1 1 1 0 ETC complex I subunit conserved region adh_short PF00106.20 ESA11546.1 - 1.7e-16 60.6 0.0 2.3e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA11546.1 - 1.2e-07 31.5 0.0 1.8e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA11546.1 - 0.042 12.7 0.0 0.073 11.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein zf-C2H2 PF00096.21 ESA11549.1 - 0.012 15.8 2.6 0.047 14.0 1.8 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESA11549.1 - 0.17 11.8 2.0 0.56 10.1 1.4 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger DUF4407 PF14362.1 ESA11549.1 - 0.86 8.4 2.4 1.5 7.7 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C2H2_4 PF13894.1 ESA11549.1 - 4.2 7.9 9.1 0.08 13.3 1.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger Guanylate_kin PF00625.16 ESA11550.1 - 0.029 13.8 2.1 0.032 13.6 0.2 1.8 1 1 0 2 2 2 0 Guanylate kinase UTP15_C PF09384.5 ESA11550.1 - 0.041 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 UTP15 C terminal TEX19 PF15553.1 ESA11550.1 - 0.16 11.8 3.7 0.24 11.2 2.5 1.3 1 0 0 1 1 1 0 Testis-expressed protein 19 Ycf1 PF05758.7 ESA11550.1 - 0.62 7.7 10.9 0.75 7.4 7.6 1.0 1 0 0 1 1 1 0 Ycf1 zf-C3HC4_2 PF13923.1 ESA11553.1 - 0.0072 16.3 2.9 0.015 15.3 2.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SKI PF01202.17 ESA11553.1 - 0.015 15.1 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Shikimate kinase zf-RING_2 PF13639.1 ESA11553.1 - 0.026 14.3 6.5 0.096 12.5 4.5 2.0 1 1 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 ESA11553.1 - 0.13 12.0 6.9 0.5 10.1 4.8 1.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-rbx1 PF12678.2 ESA11553.1 - 0.6 10.2 5.2 1.9 8.6 3.6 1.9 1 1 1 2 2 2 0 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA11553.1 - 0.97 9.1 6.5 3.1 7.5 4.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PDDEXK_2 PF12784.2 ESA11555.1 - 4.5e-22 78.3 7.5 2.1e-14 53.2 1.4 2.0 1 1 1 2 2 2 2 PD-(D/E)XK nuclease family transposase Orthopox_B11R PF07033.6 ESA11556.1 - 0.36 10.3 3.3 4.1 6.9 0.2 2.0 1 1 1 2 2 2 0 Orthopoxvirus B11R protein Ribosomal_S11 PF00411.14 ESA11557.1 - 2.9e-41 140.1 0.4 3.5e-41 139.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF2252 PF10009.4 ESA11557.1 - 0.085 11.7 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF814 PF05670.8 ESA11557.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF814) Pro_isomerase PF00160.16 ESA11558.1 - 2.7e-41 141.3 0.1 5e-41 140.4 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.17 ESA11558.1 - 2.7e-16 58.9 0.2 5e-16 58.0 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA11558.1 - 9.7e-14 51.1 0.1 1.8e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA11558.1 - 5.3e-13 48.5 0.1 1e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4407 PF14362.1 ESA11558.1 - 3.1 6.6 4.3 4.3 6.2 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FLILHELTA PF10306.4 ESA11559.1 - 1.1e-12 47.7 0.1 1.9e-12 47.0 0.0 1.4 2 0 0 2 2 2 1 Hypothetical protein FLILHELTA Ammonium_transp PF00909.16 ESA11559.1 - 0.077 11.4 0.2 0.12 10.8 0.1 1.2 1 0 0 1 1 1 0 Ammonium Transporter Family DUF1279 PF06916.8 ESA11559.1 - 0.15 12.4 1.5 0.44 10.8 1.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1279) RNase_PH PF01138.16 ESA11560.1 - 2.4e-36 124.9 0.1 3.5e-36 124.4 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESA11560.1 - 3.9e-11 42.7 0.1 9.7e-11 41.4 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Siah-Interact_N PF09032.6 ESA11560.1 - 0.037 14.0 0.0 0.074 13.1 0.0 1.6 1 0 0 1 1 1 0 Siah interacting protein, N terminal DUF1703 PF08011.6 ESA11562.1 - 0.025 14.3 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1703) TRAPPC10 PF12584.3 ESA11562.1 - 0.026 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 ProQ PF04352.8 ESA11565.1 - 0.13 11.9 0.0 0.72 9.4 0.0 2.0 2 0 0 2 2 2 0 ProQ/FINO family Delta_lysin PF05372.6 ESA11566.1 - 0.064 12.6 0.2 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Delta lysin family Pkinase_Tyr PF07714.12 ESA11567.1 - 1.9e-52 177.9 1.0 2.9e-38 131.4 0.1 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA11567.1 - 1.1e-44 152.5 6.3 1.3e-35 122.8 1.3 3.1 2 1 1 3 3 3 3 Protein kinase domain Kdo PF06293.9 ESA11567.1 - 0.00061 18.9 1.2 0.0036 16.3 0.9 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA11567.1 - 0.0023 17.2 3.2 0.0053 15.9 0.5 2.2 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA11567.1 - 0.0075 15.6 0.1 0.019 14.2 0.1 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA11567.1 - 0.0085 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA11567.1 - 0.022 13.7 0.0 0.038 12.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ESA11567.1 - 0.029 13.6 0.8 0.1 11.9 0.2 2.2 2 0 0 2 2 2 0 RIO1 family Methylase_S PF01420.14 ESA11568.1 - 0.17 11.8 3.1 0.17 11.8 2.2 1.0 1 0 0 1 1 1 0 Type I restriction modification DNA specificity domain DZR PF12773.2 ESA11569.1 - 0.00086 19.0 16.2 0.39 10.5 0.7 3.3 3 0 0 3 3 3 3 Double zinc ribbon BCS1_N PF08740.6 ESA11569.1 - 0.0086 15.7 0.0 4.5 6.8 0.0 3.2 3 0 0 3 3 3 1 BCS1 N terminal DNMT1-RFD PF12047.3 ESA11569.1 - 0.062 13.0 1.4 3.5 7.3 0.0 3.2 3 0 0 3 3 3 0 Cytosine specific DNA methyltransferase replication foci domain zf-C4pol PF14260.1 ESA11569.1 - 0.44 10.5 12.4 5.6 7.0 0.4 3.7 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta NMD3 PF04981.8 ESA11569.1 - 4.4 6.3 12.4 2.6 7.0 1.0 3.2 3 0 0 3 3 3 0 NMD3 family DUF869 PF05911.6 ESA11572.1 - 0.0054 15.0 12.4 0.0063 14.8 8.6 1.1 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) DUF4201 PF13870.1 ESA11572.1 - 0.0069 15.8 17.9 0.32 10.4 2.2 2.9 1 1 1 2 2 2 2 Domain of unknown function (DUF4201) APG6 PF04111.7 ESA11572.1 - 0.0083 15.2 16.4 0.0083 15.2 10.9 1.3 1 1 0 1 1 1 1 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 ESA11572.1 - 0.0091 15.8 17.7 0.33 10.7 3.2 2.2 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.3 ESA11572.1 - 0.013 14.8 5.3 0.013 14.8 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Reo_sigmaC PF04582.7 ESA11572.1 - 0.013 14.6 0.7 0.014 14.5 0.5 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Cast PF10174.4 ESA11572.1 - 0.013 13.5 15.3 0.12 10.4 4.3 2.0 1 1 1 2 2 2 0 RIM-binding protein of the cytomatrix active zone TMF_TATA_bd PF12325.3 ESA11572.1 - 0.03 14.0 17.5 0.31 10.7 3.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 ESA11572.1 - 0.051 13.1 21.0 0.13 11.8 14.5 1.6 1 1 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ESA11572.1 - 0.068 13.1 17.2 2.1 8.3 0.1 3.6 2 1 1 3 3 3 0 bZIP transcription factor Laminin_II PF06009.7 ESA11572.1 - 0.1 12.3 9.3 0.053 13.2 4.5 1.7 1 1 1 2 2 2 0 Laminin Domain II CCDC155 PF14662.1 ESA11572.1 - 0.12 11.9 16.5 0.17 11.4 11.4 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 DUF3578 PF12102.3 ESA11572.1 - 0.13 11.8 3.4 0.11 12.1 1.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3578) Borrelia_lipo_1 PF05714.6 ESA11572.1 - 0.16 11.0 18.4 0.22 10.5 12.7 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Nup88 PF10168.4 ESA11572.1 - 0.18 9.6 10.2 0.21 9.4 7.1 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF4200 PF13863.1 ESA11572.1 - 0.27 11.1 17.2 2.2 8.2 11.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.3 ESA11572.1 - 0.28 11.0 17.1 1 9.1 6.7 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.1 ESA11572.1 - 0.32 10.3 17.9 0.45 9.9 12.4 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Gp-FAR-1 PF05823.7 ESA11572.1 - 0.33 10.9 5.7 0.82 9.6 0.5 2.2 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Cauli_DNA-bind PF03310.8 ESA11572.1 - 0.36 10.6 3.3 1.9 8.3 0.2 2.1 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein Fib_alpha PF08702.5 ESA11572.1 - 0.55 10.3 11.6 0.76 9.8 8.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Nif11 PF07862.6 ESA11572.1 - 0.58 10.1 4.3 5.1 7.1 0.2 2.7 2 1 0 2 2 2 0 Nitrogen fixation protein of unknown function NPV_P10 PF05531.7 ESA11572.1 - 0.7 10.1 9.7 8.3 6.7 0.8 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIVA PF05103.8 ESA11572.1 - 0.72 9.9 16.7 13 5.7 0.3 3.3 1 1 0 2 2 2 0 DivIVA protein GLTSCR1 PF15249.1 ESA11572.1 - 0.74 9.9 5.5 0.52 10.4 2.7 1.5 1 1 1 2 2 2 0 Glioma tumor suppressor candidate region HAP1_N PF04849.8 ESA11572.1 - 0.76 8.6 18.1 0.94 8.3 12.5 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF4047 PF13256.1 ESA11572.1 - 0.82 9.6 9.8 0.35 10.8 1.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) TPR_MLP1_2 PF07926.7 ESA11572.1 - 0.84 9.3 19.2 1.4 8.6 5.1 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ArdA PF07275.6 ESA11572.1 - 0.9 9.7 7.8 0.7 10.1 1.7 2.0 1 1 1 2 2 2 0 Antirestriction protein (ArdA) DUF972 PF06156.8 ESA11572.1 - 1.1 9.6 14.5 1 9.7 2.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF2730 PF10805.3 ESA11572.1 - 1.3 8.7 5.0 0.5 10.1 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF4140 PF13600.1 ESA11572.1 - 1.6 9.1 11.6 6.3 7.3 0.2 3.2 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2935 PF11155.3 ESA11572.1 - 1.7 8.7 7.6 2.2 8.3 4.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) AKNA PF12443.3 ESA11572.1 - 2.2 8.3 8.7 5.3 7.1 1.5 2.3 1 1 1 2 2 2 0 AT-hook-containing transcription factor Jnk-SapK_ap_N PF09744.4 ESA11572.1 - 2.3 8.1 18.0 0.35 10.8 6.2 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 CTNNB1_binding PF08347.6 ESA11572.1 - 2.4 8.3 6.3 2.7 8.2 4.4 1.2 1 0 0 1 1 1 0 N-terminal CTNNB1 binding DUF848 PF05852.6 ESA11572.1 - 2.7 7.8 11.4 1.2 8.9 5.3 1.9 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) MCC-bdg_PDZ PF10506.4 ESA11572.1 - 2.7 7.8 8.5 2.8 7.8 3.4 2.4 1 1 1 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome V_ATPase_I PF01496.14 ESA11572.1 - 2.8 5.6 10.5 3.9 5.2 7.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2802 PF10975.3 ESA11572.1 - 2.9 7.7 6.7 0.75 9.6 0.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2802) DUF4559 PF15112.1 ESA11572.1 - 3.5 6.6 13.5 13 4.8 2.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) DivIC PF04977.10 ESA11572.1 - 3.9 7.0 17.1 2.8 7.4 3.1 3.2 1 1 1 2 2 2 0 Septum formation initiator CENP-Q PF13094.1 ESA11572.1 - 4.3 7.3 17.2 0.52 10.3 8.1 1.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Herpes_BLRF2 PF05812.7 ESA11572.1 - 6.8 6.5 10.2 5.1 6.9 1.4 2.4 1 1 0 2 2 2 0 Herpesvirus BLRF2 protein Syntaxin PF00804.20 ESA11572.1 - 8.9 6.5 13.9 6.7 6.9 8.0 1.8 1 1 0 1 1 1 0 Syntaxin DUF1664 PF07889.7 ESA11572.1 - 9.6 6.0 6.6 11 5.7 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DDE_3 PF13358.1 ESA11573.1 - 2.6e-05 23.9 0.0 4.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Sulfate_transp PF00916.15 ESA11575.1 - 1.9e-19 69.7 13.8 4.6e-09 35.6 0.7 3.9 2 2 1 4 4 4 3 Sulfate transporter family MrpF_PhaF PF04066.8 ESA11575.1 - 0.018 15.3 0.1 0.018 15.3 0.1 3.5 3 1 0 3 3 3 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) FA_hydroxylase PF04116.8 ESA11575.1 - 0.59 10.5 4.1 0.84 10.0 1.1 2.3 2 1 0 2 2 2 0 Fatty acid hydroxylase superfamily MIF4G PF02854.14 ESA11576.1 - 6.5e-57 192.3 4.6 4.3e-56 189.6 3.2 2.6 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 ESA11576.1 - 9.2e-20 70.3 3.3 1.3e-19 69.8 0.0 2.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 FANCI_S2 PF14676.1 ESA11576.1 - 0.14 12.0 0.2 3.8 7.3 0.0 2.8 3 0 0 3 3 3 0 FANCI solenoid 2 Pkinase PF00069.20 ESA11577.1 - 1e-06 28.1 0.0 1.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11577.1 - 9.5e-05 21.5 0.0 0.00011 21.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mt_ATP-synt_D PF05873.7 ESA11577.1 - 0.011 15.3 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) TBP PF00352.16 ESA11578.1 - 6e-69 227.4 0.1 7.6e-35 118.1 0.0 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 ESA11578.1 - 4.9e-05 23.3 0.0 0.34 10.9 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF3378) DLH PF01738.13 ESA11579.1 - 1.3e-33 116.1 0.0 1.6e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 ESA11579.1 - 5.1e-06 26.3 0.0 1.8e-05 24.4 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 ESA11579.1 - 0.0009 19.0 0.5 0.032 13.9 0.0 2.5 2 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.11 ESA11579.1 - 0.0031 16.9 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Lipase_3 PF01764.20 ESA11579.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.4 1 1 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.2 ESA11579.1 - 0.022 14.6 0.0 0.031 14.1 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA11579.1 - 0.079 12.5 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.7 ESA11579.1 - 0.13 10.6 0.0 0.19 10.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Exo_endo_phos PF03372.18 ESA11580.1 - 1.2e-22 81.1 0.0 1.7e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA11580.1 - 7.9e-13 48.0 0.4 3.5e-12 45.9 0.0 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 ESA11580.1 - 2.5e-09 36.9 3.2 6.8e-09 35.5 2.2 1.8 1 0 0 1 1 1 1 GRF zinc finger BCS1_N PF08740.6 ESA11581.1 - 2.5e-16 59.8 0.5 0.16 11.6 0.0 8.5 9 0 0 9 9 9 3 BCS1 N terminal TSNR_N PF04705.7 ESA11581.1 - 0.0009 19.0 0.0 45 3.8 0.0 5.2 5 0 0 5 5 5 0 Thiostrepton-resistance methylase, N terminus Guanylate_cyc PF00211.15 ESA11581.1 - 0.0019 17.5 2.3 38 3.5 0.0 5.3 6 0 0 6 6 6 0 Adenylate and Guanylate cyclase catalytic domain Phage_pRha PF09669.5 ESA11581.1 - 0.021 15.1 11.2 21 5.5 0.1 6.1 5 2 1 6 6 6 0 Phage regulatory protein Rha (Phage_pRha) Cas_Cmr5 PF09701.5 ESA11581.1 - 0.035 14.2 0.7 33 4.6 0.0 4.0 4 0 0 4 4 4 0 CRISPR-associated protein (Cas_Cmr5) AFOR_N PF02730.10 ESA11581.1 - 0.039 13.3 0.1 9 5.5 0.0 3.4 4 0 0 4 4 4 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain Frigida PF07899.6 ESA11581.1 - 0.11 11.2 0.0 10 4.7 0.0 3.6 4 1 0 4 4 4 0 Frigida-like protein FCD PF07729.7 ESA11581.1 - 0.52 10.6 0.0 1.4e+02 2.7 0.0 4.0 6 0 0 6 6 6 0 FCD domain PBP_dimer PF03717.10 ESA11581.1 - 3.4 7.6 6.9 20 5.2 0.0 4.6 5 1 0 5 5 5 0 Penicillin-binding Protein dimerisation domain LRR_7 PF13504.1 ESA11581.1 - 5.8 7.5 13.3 1.5e+02 3.3 0.0 6.4 6 0 0 6 6 6 0 Leucine rich repeat DUF4366 PF14283.1 ESA11583.1 - 0.0022 17.4 0.3 0.0025 17.2 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) Rhabdo_ncap PF00945.13 ESA11583.1 - 0.051 12.1 0.1 0.055 12.0 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF3484 PF11983.3 ESA11583.1 - 0.087 13.6 0.5 0.099 13.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) RXT2_N PF08595.6 ESA11583.1 - 0.19 11.5 1.9 0.22 11.3 1.3 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Nucleoplasmin PF03066.10 ESA11583.1 - 1.9 7.9 4.8 2.3 7.7 3.3 1.1 1 0 0 1 1 1 0 Nucleoplasmin Imm22 PF15592.1 ESA11586.1 - 0.049 13.9 0.5 0.076 13.3 0.2 1.6 1 1 0 1 1 1 0 Immunity protein 22 DUF4375 PF14300.1 ESA11586.1 - 0.052 13.5 1.9 0.063 13.2 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4375) Fib_alpha PF08702.5 ESA11586.1 - 0.15 12.2 1.9 0.17 12.0 1.3 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FTA4 PF13093.1 ESA11586.1 - 0.26 10.6 5.8 0.42 10.0 4.0 1.4 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF4373 PF14297.1 ESA11586.1 - 0.26 11.6 2.0 0.32 11.3 0.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4373) GvpG PF05120.7 ESA11586.1 - 0.31 10.8 0.1 0.31 10.8 0.1 2.5 1 1 1 2 2 2 0 Gas vesicle protein G DUF87 PF01935.12 ESA11586.1 - 0.31 10.8 3.0 0.36 10.5 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_23 PF13476.1 ESA11586.1 - 0.48 10.7 9.3 0.55 10.5 6.5 1.1 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 ESA11586.1 - 0.7 8.2 4.4 0.74 8.1 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) UPF0122 PF04297.9 ESA11586.1 - 1.4 9.0 10.5 0.19 11.7 3.8 2.0 1 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like FliT PF05400.8 ESA11588.1 - 0.1 13.0 0.0 0.25 11.7 0.0 1.6 2 0 0 2 2 2 0 Flagellar protein FliT NYD-SP28 PF14772.1 ESA11588.1 - 1.2 9.2 4.5 3.2 7.8 1.3 2.4 3 0 0 3 3 3 0 Sperm tail GBP PF02263.14 ESA11589.1 - 7e-33 113.7 3.2 2.3e-32 112.0 0.0 2.7 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain She9_MDM33 PF05546.6 ESA11589.1 - 0.0094 15.5 8.6 0.0094 15.5 6.0 2.3 2 0 0 2 2 2 1 She9 / Mdm33 family COQ9 PF08511.6 ESA11589.1 - 0.071 12.6 0.0 0.48 9.9 0.0 2.3 2 0 0 2 2 2 0 COQ9 HALZ PF02183.13 ESA11589.1 - 0.17 11.6 0.1 0.17 11.6 0.1 3.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper Med11 PF10280.4 ESA11589.1 - 0.36 10.8 9.4 0.12 12.4 3.5 2.4 2 1 0 2 2 2 0 Mediator complex protein Dynamin_N PF00350.18 ESA11589.1 - 0.39 10.5 8.3 2.2 8.0 0.0 4.0 3 2 0 3 3 3 0 Dynamin family DUF1843 PF08898.5 ESA11589.1 - 1.1 9.3 4.5 7.7 6.6 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) GBP_C PF02841.9 ESA11590.1 - 0.00012 21.4 23.0 0.025 13.7 16.0 2.3 1 1 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Herpes_UL25 PF01499.11 ESA11590.1 - 0.015 13.6 2.7 0.026 12.8 1.9 1.4 1 0 0 1 1 1 0 Herpesvirus UL25 family GBP PF02263.14 ESA11591.1 - 3.3e-15 55.8 0.0 4e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Hep_core_N PF08290.6 ESA11591.1 - 0.31 10.5 1.7 0.47 9.9 1.2 1.3 1 0 0 1 1 1 0 Hepatitis core protein, putative zinc finger AAA_12 PF13087.1 ESA11592.1 - 5.6e-21 74.8 1.1 8.9e-21 74.1 0.3 1.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 ESA11592.1 - 0.018 15.1 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 ESA11592.1 - 0.094 12.2 0.1 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF1426 PF07234.6 ESA11594.1 - 0.14 11.9 2.1 0.23 11.2 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1426) CENP-B_N PF04218.8 ESA11595.1 - 2.3e-11 42.8 0.9 1.5e-10 40.3 0.2 2.5 3 0 0 3 3 3 1 CENP-B N-terminal DNA-binding domain BrkDBD PF09607.5 ESA11595.1 - 3.1e-08 33.0 1.4 7.3e-08 31.8 0.5 2.0 1 1 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.15 ESA11595.1 - 3.1e-07 30.2 0.8 6.5e-06 26.0 0.5 2.2 2 0 0 2 2 2 1 Transposase HTH_28 PF13518.1 ESA11595.1 - 4.8e-06 26.4 2.3 1.1e-05 25.3 0.0 2.5 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA11595.1 - 5.1e-05 22.7 0.2 0.00075 19.0 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 ESA11595.1 - 0.0034 17.0 0.2 0.01 15.4 0.0 1.8 1 1 1 2 2 2 1 Transposase DUF2288 PF10052.4 ESA11595.1 - 0.11 12.1 0.9 12 5.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2288) BTB PF00651.26 ESA11597.1 - 2.5e-16 59.6 0.8 3e-15 56.1 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA11597.1 - 4.3e-08 32.9 5.3 4.9e-07 29.5 0.4 3.8 3 2 0 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ESA11597.1 - 2.1e-06 27.7 1.3 5.9e-06 26.3 0.9 1.8 1 0 0 1 1 1 1 TLD Exo_endo_phos_2 PF14529.1 ESA11598.1 - 0.036 13.6 0.7 0.036 13.6 0.5 2.2 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase TMEM210 PF15195.1 ESA11598.1 - 0.15 12.1 0.0 0.24 11.5 0.0 1.2 1 0 0 1 1 1 0 TMEM210 family DUF605 PF04652.11 ESA11600.1 - 0.00057 19.3 0.4 0.00057 19.3 0.3 1.1 1 0 0 1 1 1 1 Vta1 like Phage_int_SAM_5 PF13102.1 ESA11600.1 - 0.0071 16.3 0.3 0.0071 16.3 0.2 1.6 2 0 0 2 2 2 1 Phage integrase SAM-like domain SNARE_assoc PF09335.6 ESA11600.1 - 0.019 15.1 0.1 0.031 14.4 0.1 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein IncA PF04156.9 ESA11600.1 - 0.046 13.3 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 IncA protein Scm3 PF10384.4 ESA11600.1 - 0.064 12.7 0.5 0.17 11.3 0.4 1.8 1 0 0 1 1 1 0 Centromere protein Scm3 DUF4627 PF15425.1 ESA11600.1 - 0.071 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4627) DUF919 PF06034.6 ESA11600.1 - 0.16 11.6 1.5 0.34 10.5 1.0 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF1981 PF09324.5 ESA11603.1 - 0.26 10.8 3.0 1.6 8.3 0.2 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) Flu_NS1 PF00600.14 ESA11604.1 - 0.002 17.2 0.3 0.026 13.6 0.1 2.2 1 1 1 2 2 2 1 Influenza non-structural protein (NS1) Cytochrom_B562 PF07361.6 ESA11604.1 - 0.035 14.4 0.6 0.33 11.4 0.0 2.7 3 1 0 3 3 3 0 Cytochrome b562 IncA PF04156.9 ESA11606.1 - 0.026 14.1 50.9 0.16 11.5 10.8 3.6 2 1 2 4 4 4 0 IncA protein MAD PF05557.8 ESA11606.1 - 0.039 12.0 56.2 0.21 9.6 38.0 2.5 1 1 0 1 1 1 0 Mitotic checkpoint protein ATG16 PF08614.6 ESA11606.1 - 2.4 7.9 59.7 0.21 11.3 16.1 4.1 2 2 2 4 4 4 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 ESA11606.1 - 5.8 5.9 20.7 5.7 6.0 1.3 3.3 1 1 1 3 3 3 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.3 ESA11606.1 - 8.4 6.1 46.9 3.9 7.2 9.8 5.0 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Cu_bind_like PF02298.12 ESA11607.1 - 0.18 11.6 1.4 0.33 10.7 0.3 1.9 2 1 0 2 2 2 0 Plastocyanin-like domain Pkinase_Tyr PF07714.12 ESA11608.1 - 1.3e-05 24.4 0.0 2.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11608.1 - 0.013 14.6 0.5 0.036 13.2 0.0 1.8 1 1 0 2 2 2 0 Protein kinase domain SMI1_KNR4 PF09346.5 ESA11608.1 - 0.078 12.9 0.3 0.1 12.5 0.2 1.2 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Myb_DNA-bind_4 PF13837.1 ESA11609.1 - 5.3e-05 23.2 0.2 8e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA11609.1 - 0.0041 17.7 0.2 0.0069 17.0 0.2 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain SURF6 PF04935.7 ESA11609.1 - 0.078 12.2 1.6 0.11 11.8 1.1 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 HEXIM PF15313.1 ESA11609.1 - 0.085 13.0 0.3 0.11 12.6 0.2 1.2 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein Tetraspannin PF00335.15 ESA11610.1 - 0.032 13.5 1.7 0.035 13.3 1.2 1.2 1 0 0 1 1 1 0 Tetraspanin family Pkinase_Tyr PF07714.12 ESA11611.1 - 5.4e-06 25.6 0.0 1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11611.1 - 0.00022 20.4 1.0 0.0011 18.1 0.1 2.4 2 1 0 2 2 2 1 Protein kinase domain Zn_Tnp_IS91 PF14319.1 ESA11611.1 - 0.0011 18.3 1.2 0.0023 17.4 0.9 1.4 1 0 0 1 1 1 1 Transposase zinc-binding domain Zn-ribbon_8 PF09723.5 ESA11611.1 - 0.052 13.5 2.6 0.1 12.5 1.8 1.4 1 0 0 1 1 1 0 Zinc ribbon domain BCS1_N PF08740.6 ESA11611.1 - 0.055 13.0 0.8 0.091 12.3 0.0 1.8 2 0 0 2 2 2 0 BCS1 N terminal zf-C3HC4_3 PF13920.1 ESA11611.1 - 0.1 12.3 2.7 0.17 11.5 1.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.12 ESA11612.1 - 3.2e-25 88.6 0.1 4.1e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11612.1 - 7.8e-23 80.9 1.8 1.6e-22 79.9 1.2 1.5 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA11612.1 - 0.0021 17.6 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal DUF2439 PF10382.4 ESA11612.1 - 0.068 13.3 0.1 0.26 11.4 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) Pkinase PF00069.20 ESA11615.1 - 6.9e-31 107.3 0.1 1.1e-30 106.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11615.1 - 1.2e-28 99.9 0.1 3.4e-26 91.8 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase WaaY PF06176.6 ESA11615.1 - 0.00021 20.6 1.1 0.00079 18.7 0.6 1.9 1 1 1 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA11615.1 - 0.00057 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA11615.1 - 0.0068 15.7 0.5 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 RIO1 family DUF2373 PF10180.4 ESA11615.1 - 0.05 13.1 0.6 14 5.2 0.1 3.5 3 1 1 4 4 4 0 Uncharacterised conserved protein (DUF2373) AIG1 PF04548.11 ESA11617.1 - 4.8e-17 61.7 0.0 5.1e-17 61.6 0.0 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA11617.1 - 6e-08 32.6 0.0 7.5e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA11617.1 - 0.0018 17.4 0.1 0.0036 16.4 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 ESA11617.1 - 0.016 15.0 0.9 1.6 8.5 0.1 2.1 1 1 1 2 2 2 0 Dynamin family FeoB_N PF02421.13 ESA11617.1 - 0.031 13.5 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESA11617.1 - 0.11 11.8 0.2 0.47 9.8 0.1 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AIG1 PF04548.11 ESA11618.1 - 3.9e-17 62.0 0.1 4.6e-17 61.8 0.1 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA11618.1 - 1.6e-07 31.2 0.0 1.8e-07 31.0 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA11618.1 - 2.9e-05 23.3 0.1 4.4e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESA11618.1 - 0.0029 16.8 0.0 0.0036 16.5 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.13 ESA11618.1 - 0.015 14.2 0.1 0.019 14.0 0.0 1.0 1 0 0 1 1 1 0 Septin SRPRB PF09439.5 ESA11618.1 - 0.032 13.4 0.0 0.038 13.2 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 ESA11618.1 - 0.037 13.8 1.1 0.63 9.8 0.1 2.1 1 1 1 2 2 2 0 Dynamin family GTP_EFTU PF00009.22 ESA11618.1 - 0.062 12.7 0.7 0.25 10.7 0.4 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain CCDC74_C PF14917.1 ESA11619.1 - 0.0024 17.9 5.1 0.003 17.6 3.5 1.3 1 0 0 1 1 1 1 Coiled coil protein 74, C terminal KAP_NTPase PF07693.9 ESA11619.1 - 0.02 13.8 3.5 0.024 13.6 2.4 1.2 1 0 0 1 1 1 0 KAP family P-loop domain OEP PF02321.13 ESA11619.1 - 0.088 12.3 7.0 0.11 12.1 4.9 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein Phage_GPO PF05929.6 ESA11619.1 - 0.1 11.7 7.0 0.12 11.5 4.9 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Peptidase_U57 PF05582.7 ESA11619.1 - 0.25 10.2 7.3 0.29 10.0 5.1 1.0 1 0 0 1 1 1 0 YabG peptidase U57 PMC2NT PF08066.7 ESA11619.1 - 0.26 11.6 5.5 0.17 12.1 2.0 1.8 1 1 1 2 2 2 0 PMC2NT (NUC016) domain DUF948 PF06103.6 ESA11619.1 - 0.26 11.1 3.3 0.38 10.6 2.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) IncA PF04156.9 ESA11619.1 - 0.34 10.4 11.9 0.43 10.1 8.3 1.2 1 0 0 1 1 1 0 IncA protein Fmp27_WPPW PF10359.4 ESA11619.1 - 0.35 9.2 9.7 0.36 9.1 6.8 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF745 PF05335.8 ESA11619.1 - 0.39 10.1 7.4 0.47 9.9 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Ax_dynein_light PF10211.4 ESA11619.1 - 0.5 10.1 17.2 0.77 9.5 11.9 1.3 1 1 0 1 1 1 0 Axonemal dynein light chain Allexi_40kDa PF05549.6 ESA11619.1 - 0.69 9.1 4.5 0.73 9.0 3.1 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.1 ESA11619.1 - 0.89 9.9 12.6 0.57 10.5 7.0 1.8 1 1 1 2 2 2 0 Snapin/Pallidin PI3K_p85B PF02192.11 ESA11619.1 - 1 8.8 8.1 0.81 9.1 2.7 2.6 2 1 0 2 2 2 0 PI3-kinase family, p85-binding domain NPV_P10 PF05531.7 ESA11619.1 - 1.1 9.5 6.4 5.4 7.3 4.4 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3782 PF12644.2 ESA11619.1 - 1.2 8.9 4.4 1.8 8.4 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) MtrG PF04210.8 ESA11619.1 - 1.4 8.6 7.1 0.25 11.0 1.1 2.3 1 1 2 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Uds1 PF15456.1 ESA11619.1 - 1.5 8.8 12.6 0.77 9.7 5.6 2.0 1 1 1 2 2 2 0 Up-regulated During Septation OmpH PF03938.9 ESA11619.1 - 1.6 8.6 11.9 2 8.3 8.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF607 PF04678.8 ESA11619.1 - 2.8 7.8 5.6 3.4 7.5 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Atrophin-1 PF03154.10 ESA11619.1 - 2.9 5.9 8.5 2.6 6.0 5.9 1.0 1 0 0 1 1 1 0 Atrophin-1 family AAA_23 PF13476.1 ESA11619.1 - 3.2 8.0 14.1 4.1 7.6 9.8 1.1 1 0 0 1 1 1 0 AAA domain DUF4337 PF14235.1 ESA11619.1 - 3.5 7.4 5.4 3.9 7.2 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF2514 PF10721.4 ESA11619.1 - 4.7 6.8 8.9 7 6.3 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Mnd1 PF03962.10 ESA11619.1 - 5 6.7 15.8 7 6.2 11.0 1.4 1 1 0 1 1 1 0 Mnd1 family GrpE PF01025.14 ESA11619.1 - 5.5 6.4 14.0 17 4.8 9.7 1.8 1 1 0 1 1 1 0 GrpE SPT16 PF08644.6 ESA11619.1 - 5.8 6.7 11.4 9.6 6.0 7.9 1.4 1 1 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Fzo_mitofusin PF04799.8 ESA11619.1 - 6 6.2 8.0 8.6 5.7 5.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region TMPIT PF07851.8 ESA11619.1 - 7.2 5.5 8.1 8.1 5.4 5.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF2203 PF09969.4 ESA11619.1 - 7.2 6.8 8.3 9.7 6.4 5.8 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Atg14 PF10186.4 ESA11619.1 - 7.5 5.3 15.1 9.1 5.1 10.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Vps51 PF08700.6 ESA11619.1 - 7.7 6.4 11.2 3.3 7.6 5.5 1.9 1 1 1 2 2 2 0 Vps51/Vps67 AAA_11 PF13086.1 ESA11619.1 - 9.8 5.6 8.3 10 5.5 5.7 1.1 1 0 0 1 1 1 0 AAA domain p450 PF00067.17 ESA11620.1 - 4.2e-77 259.6 0.2 5.3e-77 259.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MULE PF10551.4 ESA11621.1 - 3.6e-08 33.4 0.2 8.9e-08 32.2 0.1 1.7 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.13 ESA11621.1 - 0.00065 18.3 0.2 0.0013 17.3 0.1 1.5 1 0 0 1 1 1 1 Transposase, Mutator family EppA_BapA PF07268.6 ESA11621.1 - 0.011 15.3 0.1 0.029 14.0 0.1 1.7 1 0 0 1 1 1 0 Exported protein precursor (EppA/BapA) Phosphodiest PF01663.17 ESA11624.1 - 2.3e-19 69.9 0.3 2.7e-19 69.7 0.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 ESA11624.1 - 2.5e-06 27.1 0.2 4.5e-06 26.2 0.1 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily Sulfatase PF00884.18 ESA11624.1 - 5.1e-06 25.9 0.1 6.3e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.12 ESA11624.1 - 0.0097 14.3 0.0 0.014 13.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Pkinase_Tyr PF07714.12 ESA11625.1 - 1.3e-19 70.3 0.0 3.4e-19 68.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11625.1 - 5.5e-17 61.7 3.5 7.8e-17 61.2 0.4 2.1 2 0 0 2 2 2 1 Protein kinase domain BCS1_N PF08740.6 ESA11625.1 - 0.06 12.9 0.0 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 BCS1 N terminal APH PF01636.18 ESA11625.1 - 0.069 12.8 0.1 0.099 12.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.26 ESA11626.1 - 4.4e-15 55.6 1.4 7.9e-15 54.8 1.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA11626.1 - 1.2e-06 28.6 0.5 2.3e-06 27.6 0.3 1.5 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA11628.1 - 1.4e-14 54.0 0.8 2.6e-14 53.1 0.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA11628.1 - 1.7e-08 34.5 0.5 3.2e-08 33.6 0.4 1.5 1 0 0 1 1 1 1 SPRY domain DUF1366 PF07104.6 ESA11628.1 - 0.0072 15.9 0.1 0.016 14.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1366) Brix PF04427.13 ESA11628.1 - 0.014 15.0 0.5 0.03 13.9 0.0 1.8 2 0 0 2 2 2 0 Brix domain DUF1642 PF07852.6 ESA11628.1 - 0.02 15.2 0.4 0.09 13.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) DUF4494 PF14902.1 ESA11628.1 - 0.06 12.9 2.1 0.76 9.3 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4494) VD10_N PF08476.5 ESA11628.1 - 0.088 12.2 0.7 0.22 11.0 0.5 1.7 1 0 0 1 1 1 0 Viral D10 N-terminal NTP_transferase PF00483.18 ESA11630.1 - 2.1e-31 109.1 0.0 3.1e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 ESA11630.1 - 3.6e-08 32.5 9.4 9.3e-06 24.9 0.3 3.7 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 ESA11630.1 - 8.6e-08 32.4 0.0 1.6e-07 31.5 0.0 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 ESA11630.1 - 0.053 13.0 1.1 0.2 11.2 0.8 2.1 1 1 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Adap_comp_sub PF00928.16 ESA11631.1 - 5.6e-93 310.8 0.0 7.1e-93 310.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESA11631.1 - 3.3e-05 23.6 0.4 6.1e-05 22.7 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SH3_5 PF08460.5 ESA11631.1 - 0.077 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain Arrestin_N PF00339.24 ESA11632.1 - 2.6e-13 50.0 0.4 4.5e-13 49.2 0.2 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Myb_DNA-binding PF00249.26 ESA11634.1 - 3.5e-09 36.5 0.7 5.3e-09 35.9 0.5 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA11634.1 - 2e-06 27.7 0.2 3.2e-06 27.1 0.2 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain LSM PF01423.17 ESA11635.1 - 2.4e-19 68.6 0.1 3.3e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain Pkinase_Tyr PF07714.12 ESA11636.1 - 1e-10 41.1 0.0 6.1e-09 35.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA11636.1 - 1.4e-06 27.6 2.9 8e-05 21.9 0.5 2.9 2 1 0 2 2 2 2 Protein kinase domain BCS1_N PF08740.6 ESA11636.1 - 0.00038 20.1 0.0 0.7 9.4 0.0 2.4 2 0 0 2 2 2 2 BCS1 N terminal SF3a60_bindingd PF12108.3 ESA11636.1 - 0.056 12.9 2.6 7.6 6.1 0.0 3.5 3 0 0 3 3 3 0 Splicing factor SF3a60 binding domain CoatB PF10389.4 ESA11640.1 - 0.26 11.1 1.0 0.39 10.5 0.7 1.3 1 0 0 1 1 1 0 Bacteriophage coat protein B zf-CCHC PF00098.18 ESA11641.1 - 0.029 14.3 0.4 0.029 14.3 0.3 3.5 4 0 0 4 4 4 0 Zinc knuckle zf-CXXC PF02008.15 ESA11641.1 - 0.06 13.1 0.6 0.06 13.1 0.4 3.0 3 1 0 3 3 3 0 CXXC zinc finger domain HypA PF01155.14 ESA11641.1 - 1.2 8.9 8.2 0.16 11.6 0.9 2.6 2 1 1 3 3 3 0 Hydrogenase expression/synthesis hypA family Exo_endo_phos PF03372.18 ESA11643.1 - 0.0072 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA11643.1 - 0.011 15.2 0.1 0.043 13.4 0.0 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Hormone_3 PF00159.13 ESA11643.1 - 0.12 12.3 0.8 0.28 11.2 0.6 1.6 1 0 0 1 1 1 0 Pancreatic hormone peptide Vhr1 PF04001.8 ESA11643.1 - 0.18 11.7 8.2 0.053 13.4 1.8 2.9 2 1 2 4 4 4 0 Transcription factor Vhr1 EF-hand_7 PF13499.1 ESA11644.1 - 4.5e-21 74.7 14.4 5.5e-12 45.6 3.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESA11644.1 - 5.3e-20 69.1 18.7 1.1e-06 27.5 2.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESA11644.1 - 2.1e-19 67.5 16.0 1.1e-05 24.8 0.1 4.6 4 1 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 ESA11644.1 - 7.9e-16 57.4 18.4 4.4e-12 45.4 1.6 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA11644.1 - 1.9e-10 39.5 14.7 0.00014 20.9 0.0 4.1 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.1 ESA11644.1 - 8.4e-08 32.0 0.6 8.6e-05 22.3 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESA11644.1 - 2.8e-05 23.7 7.4 0.0036 16.9 0.6 3.0 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand MgtE_N PF03448.12 ESA11644.1 - 0.016 15.5 0.8 0.016 15.5 0.6 2.1 3 0 0 3 3 3 0 MgtE intracellular N domain SPARC_Ca_bdg PF10591.4 ESA11644.1 - 0.63 10.0 4.1 1.2 9.1 0.6 2.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_like PF09279.6 ESA11644.1 - 1.6 8.7 5.5 2.5 8.1 0.8 2.6 2 1 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like PUB PF09409.5 ESA11645.1 - 2.2e-14 52.9 3.2 2.2e-14 52.9 2.2 2.1 2 1 1 3 3 3 1 PUB domain Asp-B-Hydro_N PF05279.6 ESA11645.1 - 0.0059 16.4 12.1 0.0066 16.3 8.4 1.2 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region PXA PF02194.10 ESA11645.1 - 0.01 15.4 4.7 0.017 14.7 3.2 1.3 1 0 0 1 1 1 0 PXA domain DUF342 PF03961.8 ESA11645.1 - 0.067 11.6 8.6 0.078 11.3 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SWI-SNF_Ssr4 PF08549.5 ESA11645.1 - 3.4 5.8 6.9 4.4 5.4 4.8 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF3650 PF12368.3 ESA11646.1 - 0.054 13.0 0.2 0.075 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3650) zf-B_box PF00643.19 ESA11647.1 - 9.6 6.2 10.8 15 5.5 7.5 1.3 1 0 0 1 1 1 0 B-box zinc finger Vfa1 PF08432.5 ESA11648.1 - 6.6e-32 111.0 11.6 8e-32 110.7 8.0 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.2 ESA11648.1 - 0.21 9.2 9.5 0.22 9.1 6.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1675 PF07897.6 ESA11648.1 - 0.6 9.9 8.5 0.76 9.5 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) AIF_C PF14721.1 ESA11648.1 - 0.61 10.3 6.6 1.3 9.3 4.6 1.6 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAM176 PF14851.1 ESA11648.1 - 1.1 8.9 6.6 1.8 8.1 4.6 1.4 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.9 ESA11648.1 - 3.8 5.4 12.3 4.6 5.1 8.5 1.0 1 0 0 1 1 1 0 CDC45-like protein ArfGap PF01412.13 ESA11649.1 - 6e-05 22.8 2.7 0.00017 21.3 0.6 2.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf S-methyl_trans PF02574.11 ESA11650.1 - 2.5e-91 306.1 0.0 5e-91 305.1 0.0 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Met_synt_B12 PF02965.12 ESA11650.1 - 7.4e-67 224.6 0.0 1.9e-66 223.2 0.0 1.7 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.17 ESA11650.1 - 6.9e-43 146.4 0.9 1.8e-42 145.1 0.2 2.2 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.12 ESA11650.1 - 7.9e-20 70.6 0.0 3e-19 68.8 0.0 2.1 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.14 ESA11650.1 - 5.1e-19 68.3 0.1 7.4e-18 64.5 0.1 2.9 2 1 0 2 2 2 1 B12 binding domain Pkinase_Tyr PF07714.12 ESA11651.1 - 5.2e-13 48.6 0.0 7.1e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11651.1 - 2.8e-11 43.0 0.0 4.3e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Thioredoxin_8 PF13905.1 ESA11651.1 - 2.2 8.4 8.2 0.31 11.1 0.2 2.6 3 0 0 3 3 3 0 Thioredoxin-like UPF0547 PF10571.4 ESA11654.1 - 0.013 15.1 1.5 0.013 15.1 1.1 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.7 ESA11654.1 - 0.67 9.7 6.6 0.37 10.6 1.7 2.5 2 0 0 2 2 2 0 zinc-ribbons zf-Di19 PF05605.7 ESA11654.1 - 3.2 7.9 12.6 0.51 10.4 1.6 2.9 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding TagA PF12561.3 ESA11655.1 - 0.085 12.8 0.1 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 ToxR activated gene A lipoprotein Herpes_Helicase PF02689.9 ESA11656.1 - 0.0032 15.2 0.0 0.0036 15.1 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA11656.1 - 0.0045 17.0 0.0 0.0059 16.7 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Reoviridae_Vp9 PF08978.5 ESA11659.1 - 0.99 8.3 4.5 2.8 6.8 1.6 2.3 2 1 0 2 2 2 0 Reoviridae VP9 Pkinase PF00069.20 ESA11660.1 - 2.8e-15 56.1 0.0 3.7e-15 55.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11660.1 - 2.4e-14 53.0 0.0 3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ACCA PF03255.9 ESA11660.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Pkinase PF00069.20 ESA11661.1 - 1.8e-48 164.9 0.1 3.5e-48 164.0 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11661.1 - 4e-19 68.7 0.0 7.3e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA11661.1 - 0.0052 16.5 0.5 0.0091 15.7 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DIPSY PF11763.3 ESA11661.1 - 0.03 14.1 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal RIO1 PF01163.17 ESA11661.1 - 0.044 13.1 0.2 0.13 11.6 0.2 1.8 1 1 0 1 1 1 0 RIO1 family Acetyltransf_3 PF13302.1 ESA11663.1 - 4.5e-16 59.3 0.0 6.3e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA11663.1 - 6.6e-05 22.8 1.2 0.00011 22.1 0.7 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA11663.1 - 0.0023 17.9 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 ESA11663.1 - 0.052 13.3 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein Imp-YgjV PF10688.4 ESA11665.1 - 0.11 11.8 0.3 0.13 11.6 0.2 1.1 1 0 0 1 1 1 0 Bacterial inner membrane protein Alg6_Alg8 PF03155.10 ESA11666.1 - 9.2e-61 206.1 15.7 1.1e-60 205.9 10.9 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family PepSY_TM_3 PF13706.1 ESA11666.1 - 0.12 11.8 4.7 0.28 10.6 0.0 3.1 3 0 0 3 3 3 0 PepSY-associated TM helix DUF3810 PF12725.2 ESA11666.1 - 0.46 9.3 13.5 0.045 12.6 6.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF4131 PF13567.1 ESA11666.1 - 2.3 7.6 8.8 0.65 9.3 0.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) p450 PF00067.17 ESA11667.1 - 1.8e-09 36.6 0.0 4.2e-06 25.5 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Peptidase_M16_C PF05193.16 ESA11668.1 - 9e-14 51.5 0.1 3.3e-13 49.7 0.0 2.0 2 1 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 ESA11668.1 - 1.8e-05 24.5 1.1 2.1e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) UQ_con PF00179.21 ESA11669.1 - 2e-49 166.6 0.0 2.3e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA11669.1 - 0.15 11.9 2.0 0.48 10.3 1.4 2.0 1 1 0 1 1 1 0 RWD domain PDCD9 PF07147.7 ESA11670.1 - 0.046 12.5 0.0 0.046 12.5 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) Leu_zip PF15294.1 ESA11670.1 - 0.081 12.0 0.1 0.091 11.8 0.1 1.1 1 0 0 1 1 1 0 Leucine zipper DUF1792 PF08759.6 ESA11671.1 - 0.0028 17.2 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1792) DUF1227 PF06777.6 ESA11671.1 - 0.029 14.0 0.1 0.058 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1227) DUF4413 PF14372.1 ESA11671.1 - 0.27 11.2 3.6 0.17 11.9 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) EphA2_TM PF14575.1 ESA11673.1 - 0.024 15.0 0.3 0.077 13.3 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF1180 PF06679.7 ESA11673.1 - 0.059 13.2 0.1 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2215 PF10225.4 ESA11673.1 - 0.24 10.8 4.8 0.33 10.3 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2215) CN_hydrolase PF00795.17 ESA11676.1 - 8.4e-32 110.0 0.0 3e-31 108.1 0.0 1.7 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase DUF327 PF03885.8 ESA11677.1 - 0.39 10.5 3.7 0.48 10.2 1.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF327) HMG_box PF00505.14 ESA11678.1 - 7.3e-08 32.5 2.8 8.9e-08 32.2 2.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box DUF2483 PF10656.4 ESA11678.1 - 0.0081 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical protein of unknown function (DUF2483) Pkinase PF00069.20 ESA11679.1 - 5.9e-67 225.5 0.0 9e-67 224.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11679.1 - 1.7e-26 92.8 0.0 2.7e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.1 ESA11679.1 - 5.9e-18 65.1 0.2 1.1e-05 25.7 0.0 4.2 3 1 0 3 3 3 3 PAS domain PAS PF00989.19 ESA11679.1 - 4.3e-09 36.1 0.0 0.0055 16.4 0.0 4.0 3 1 0 3 3 3 2 PAS fold Kinase-like PF14531.1 ESA11679.1 - 5.2e-09 35.4 0.0 8.5e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA11679.1 - 1e-05 24.7 0.1 1.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA11679.1 - 4.1e-05 23.4 0.3 0.017 14.9 0.2 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 ESA11679.1 - 0.00011 21.5 0.1 0.00025 20.4 0.0 1.5 1 0 0 1 1 1 1 RIO1 family PAS_4 PF08448.5 ESA11679.1 - 0.00016 21.6 0.0 9.8 6.2 0.0 3.5 3 0 0 3 3 3 2 PAS fold Tn916-Xis PF09035.5 ESA11679.1 - 0.054 13.5 0.0 8.1 6.6 0.0 3.2 3 0 0 3 3 3 0 Excisionase from transposon Tn916 Rubredoxin PF00301.15 ESA11680.1 - 0.0031 17.3 1.0 0.009 15.8 0.7 1.8 1 0 0 1 1 1 1 Rubredoxin Pkinase PF00069.20 ESA11682.1 - 2.2e-15 56.5 0.2 4.7e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11682.1 - 1.7e-13 50.2 0.0 2.4e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA11682.1 - 0.0023 17.6 0.1 0.0082 15.8 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family D5_N PF08706.6 ESA11682.1 - 0.081 13.0 2.3 0.82 9.7 0.1 2.5 1 1 1 2 2 2 0 D5 N terminal like UVR PF02151.14 ESA11683.1 - 0.047 13.2 9.2 0.62 9.6 2.3 2.7 2 0 0 2 2 2 0 UvrB/uvrC motif Myb_DNA-bind_5 PF13873.1 ESA11685.1 - 0.00022 21.0 10.6 0.28 11.1 0.1 4.0 3 1 0 4 4 4 3 Myb/SANT-like DNA-binding domain Sec20 PF03908.8 ESA11685.1 - 0.00023 20.7 23.0 0.0098 15.5 3.2 3.3 1 1 2 3 3 3 2 Sec20 IncA PF04156.9 ESA11685.1 - 0.00054 19.6 35.7 0.28 10.7 17.7 3.0 1 1 1 2 2 2 2 IncA protein TMF_DNA_bd PF12329.3 ESA11685.1 - 0.00057 19.6 46.7 0.034 13.9 2.8 4.8 2 1 3 5 5 5 3 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.4 ESA11685.1 - 0.0015 18.3 37.7 0.0041 16.9 16.8 2.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG17 PF04108.7 ESA11685.1 - 0.0022 16.8 29.9 0.015 14.0 10.5 2.3 1 1 1 2 2 2 2 Autophagy protein Apg17 Atg14 PF10186.4 ESA11685.1 - 0.0026 16.7 18.7 0.0026 16.7 13.0 2.0 1 1 1 2 2 2 2 UV radiation resistance protein and autophagy-related subunit 14 DUF3885 PF13021.1 ESA11685.1 - 0.0091 15.6 29.1 0.013 15.1 0.4 5.5 4 1 1 5 5 5 1 Domain of unknown function (DUF3885) FadA PF09403.5 ESA11685.1 - 0.015 15.2 43.6 0.029 14.4 14.9 2.5 1 1 2 3 3 3 0 Adhesion protein FadA HALZ PF02183.13 ESA11685.1 - 0.025 14.2 4.6 0.025 14.2 3.2 5.5 3 2 3 6 6 6 0 Homeobox associated leucine zipper Myosin_tail_1 PF01576.14 ESA11685.1 - 0.026 12.2 41.2 0.016 12.9 21.5 1.9 1 1 1 2 2 2 0 Myosin tail DUF883 PF05957.8 ESA11685.1 - 0.035 14.4 9.5 1.2 9.5 0.4 3.6 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF883) DUF4600 PF15372.1 ESA11685.1 - 0.069 13.3 37.0 0.11 12.7 6.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) Cortex-I_coil PF09304.5 ESA11685.1 - 0.073 13.1 31.8 0.18 11.8 4.5 3.2 1 1 2 3 3 3 0 Cortexillin I, coiled coil SYCE1 PF15233.1 ESA11685.1 - 0.33 10.8 36.6 0.43 10.5 9.1 2.9 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 RmuC PF02646.11 ESA11685.1 - 0.74 8.5 23.7 0.81 8.4 2.0 3.3 1 1 2 3 3 3 0 RmuC family DUF812 PF05667.6 ESA11685.1 - 0.78 8.1 37.0 0.012 14.1 17.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF4446 PF14584.1 ESA11685.1 - 0.79 9.5 26.4 1.2 8.9 2.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) TPR_MLP1_2 PF07926.7 ESA11685.1 - 1.1 9.0 45.9 1.1 9.0 14.2 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ApoO PF09769.4 ESA11685.1 - 1.3 8.7 10.4 2.5 7.8 2.2 2.8 1 1 1 2 2 2 0 Apolipoprotein O DUF2670 PF10875.3 ESA11685.1 - 1.4 8.9 12.5 2.9 7.9 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) NAAA-beta PF15508.1 ESA11685.1 - 2 8.7 7.8 9.7 6.6 0.3 3.1 1 1 2 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase HAUS6_N PF14661.1 ESA11685.1 - 2.2 7.5 25.2 0.18 11.1 3.8 3.0 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus She9_MDM33 PF05546.6 ESA11685.1 - 2.3 7.6 26.2 5.9 6.3 1.6 3.9 1 1 2 4 4 4 0 She9 / Mdm33 family DUF3584 PF12128.3 ESA11685.1 - 2.5 5.3 37.9 2.7 5.1 26.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HJURP_C PF12347.3 ESA11685.1 - 3 7.5 22.2 0.48 10.0 1.5 3.9 2 2 1 4 4 4 0 Holliday junction regulator protein family C-terminal repeat APG6 PF04111.7 ESA11685.1 - 3.8 6.4 45.8 0.59 9.1 17.5 2.9 1 1 2 3 3 3 0 Autophagy protein Apg6 DUF948 PF06103.6 ESA11685.1 - 4 7.3 19.5 0.85 9.5 1.4 3.6 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) bZIP_Maf PF03131.12 ESA11685.1 - 4.6 7.6 20.6 2.4 8.5 0.9 4.2 1 1 3 4 4 4 0 bZIP Maf transcription factor DUF4407 PF14362.1 ESA11685.1 - 5.5 5.8 27.9 3 6.7 7.7 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) CALCOCO1 PF07888.6 ESA11685.1 - 5.9 5.0 30.0 1.8 6.7 12.7 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Vac_Fusion PF02346.11 ESA11685.1 - 6.1 6.3 10.9 20 4.6 0.1 4.8 3 2 2 5 5 5 0 Chordopoxvirus fusion protein IMD PF08397.6 ESA11685.1 - 6.3 6.0 38.1 0.85 8.8 10.3 2.9 1 1 2 3 3 3 0 IRSp53/MIM homology domain OmpH PF03938.9 ESA11685.1 - 7.2 6.5 40.2 1.2 9.0 7.3 3.2 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.3 ESA11685.1 - 7.2 5.7 31.8 3.7 6.7 3.4 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Ax_dynein_light PF10211.4 ESA11685.1 - 9.1 6.0 40.9 0.58 9.9 7.4 3.6 1 1 2 3 3 3 0 Axonemal dynein light chain Smr PF01713.16 ESA11687.1 - 0.0014 18.7 0.0 0.0016 18.5 0.0 1.3 1 1 0 1 1 1 1 Smr domain Xpo1 PF08389.7 ESA11688.1 - 8.6e-13 48.4 12.8 6.6e-08 32.5 0.0 3.9 4 0 0 4 4 4 2 Exportin 1-like protein IBN_N PF03810.14 ESA11688.1 - 2.9e-05 23.9 1.2 7.5e-05 22.5 0.2 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Acyltransferase PF01553.16 ESA11690.1 - 2.9e-10 39.6 0.0 2.5e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 Acyltransferase DUF2418 PF10332.4 ESA11691.1 - 3.9e-24 84.8 0.0 3.9e-24 84.8 0.0 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2418) Herpes_LMP1 PF05297.6 ESA11691.1 - 5.8 5.7 6.8 8.6 5.1 4.7 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Smr PF01713.16 ESA11692.1 - 3.3e-10 40.0 0.0 4.4e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Smr domain OppC_N PF12911.2 ESA11692.1 - 0.14 11.5 0.3 0.18 11.1 0.2 1.2 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C MFS_1 PF07690.11 ESA11693.1 - 0.0012 17.6 3.2 0.0012 17.6 2.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily SdpI PF13630.1 ESA11693.1 - 7 6.4 9.7 6.7 6.5 3.9 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family Ribosomal_L6e PF01159.14 ESA11695.1 - 0.1 12.8 0.3 0.19 12.0 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein L6e 7tm_1 PF00001.16 ESA11699.1 - 2.6e-06 26.7 11.3 5.6e-06 25.6 7.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ABC2_membrane_3 PF12698.2 ESA11700.1 - 9.8 5.0 11.9 14 4.6 8.3 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein F-box-like PF12937.2 ESA11703.1 - 6.4e-07 28.9 1.5 1.7e-06 27.6 0.6 2.1 2 0 0 2 2 2 1 F-box-like SUI1 PF01253.17 ESA11704.1 - 1.6e-14 53.4 0.0 5.1e-14 51.8 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.13 ESA11704.1 - 5.2e-05 22.8 0.1 0.00019 21.0 0.0 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain PUA PF01472.15 ESA11704.1 - 0.00075 19.1 0.5 0.0032 17.1 0.1 2.1 2 0 0 2 2 2 1 PUA domain Pkinase_Tyr PF07714.12 ESA11705.1 - 0.018 14.1 0.1 0.03 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase p450 PF00067.17 ESA11706.1 - 1.8e-44 152.0 0.1 2.2e-44 151.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_11 PF08241.7 ESA11708.1 - 4.5e-17 62.3 0.0 2e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA11708.1 - 2.5e-15 56.5 0.0 3.7e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA11708.1 - 3.2e-14 52.7 0.0 6.8e-14 51.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA11708.1 - 1.9e-12 47.4 0.0 4.2e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA11708.1 - 9.6e-12 45.1 0.0 1.8e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA11708.1 - 1.8e-10 41.4 0.0 7.4e-10 39.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA11708.1 - 4.3e-10 39.1 0.0 9.1e-10 38.0 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ESA11708.1 - 4.2e-07 29.5 0.0 7e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA11708.1 - 4.9e-07 29.7 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESA11708.1 - 1.6e-06 27.4 0.0 4.1e-06 26.0 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 ESA11708.1 - 9.2e-06 24.8 0.0 2.3e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.13 ESA11708.1 - 0.00049 19.3 0.0 0.00075 18.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase FtsJ PF01728.14 ESA11708.1 - 0.00079 19.4 0.0 0.0023 17.9 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 ESA11708.1 - 0.0017 18.0 0.0 0.0038 16.9 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 ESA11708.1 - 0.0094 15.3 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.13 ESA11708.1 - 0.054 12.7 0.0 0.13 11.5 0.0 1.6 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MAM33 PF02330.11 ESA11709.1 - 3e-27 95.7 16.3 4e-22 79.0 1.4 2.3 1 1 1 2 2 2 2 Mitochondrial glycoprotein Nucleoplasmin PF03066.10 ESA11709.1 - 0.0043 16.5 7.8 0.0043 16.5 5.4 2.3 2 0 0 2 2 2 1 Nucleoplasmin TFIIA PF03153.8 ESA11709.1 - 0.019 14.8 9.8 0.024 14.5 6.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mpp10 PF04006.7 ESA11709.1 - 0.85 7.9 23.4 1.3 7.2 16.2 1.3 1 1 0 1 1 1 0 Mpp10 protein BSP_II PF05432.6 ESA11709.1 - 2.2 7.4 20.3 0.24 10.6 10.9 1.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Fez1 PF06818.10 ESA11710.1 - 1.8e-05 24.8 21.5 0.00017 21.6 8.3 2.3 1 1 1 2 2 2 1 Fez1 ADIP PF11559.3 ESA11710.1 - 0.0013 18.6 40.1 0.019 14.8 6.1 3.3 1 1 2 3 3 3 3 Afadin- and alpha -actinin-Binding Myb_DNA-bind_5 PF13873.1 ESA11710.1 - 0.0051 16.6 10.3 0.37 10.7 0.6 4.5 2 2 2 4 4 4 2 Myb/SANT-like DNA-binding domain IncA PF04156.9 ESA11710.1 - 0.0056 16.3 37.9 0.11 12.1 14.6 2.4 1 1 1 2 2 2 2 IncA protein CENP-F_leu_zip PF10473.4 ESA11710.1 - 0.0082 15.9 34.0 0.42 10.4 5.6 2.4 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mnd1 PF03962.10 ESA11710.1 - 0.047 13.3 33.2 0.26 10.9 13.2 2.7 1 1 0 2 2 2 0 Mnd1 family NAAA-beta PF15508.1 ESA11710.1 - 0.047 14.0 6.4 1.7 9.0 0.2 2.9 2 1 1 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase PilJ PF13675.1 ESA11710.1 - 0.053 13.8 6.9 1.3 9.3 2.4 3.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pro-kuma_activ PF09286.6 ESA11710.1 - 0.068 13.2 4.7 0.73 9.8 0.1 2.6 2 1 0 2 2 2 0 Pro-kumamolisin, activation domain CCDC155 PF14662.1 ESA11710.1 - 0.97 8.9 35.1 0.2 11.2 11.6 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 SlyX PF04102.7 ESA11710.1 - 1.5 9.2 22.3 0.12 12.7 5.8 3.8 4 0 0 4 4 3 0 SlyX DUF1795 PF08786.6 ESA11710.1 - 2 8.2 5.5 3.6 7.4 0.9 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1795) DUF641 PF04859.7 ESA11710.1 - 3.5 7.3 24.4 0.5 10.1 3.5 3.4 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF1779 PF08680.5 ESA11710.1 - 5.6 6.7 29.7 5.5 6.7 4.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1779) HAUS6_N PF14661.1 ESA11710.1 - 7.1 5.8 26.7 1 8.6 2.4 3.5 2 1 2 4 4 4 0 HAUS augmin-like complex subunit 6 N-terminus APG6 PF04111.7 ESA11710.1 - 7.9 5.4 46.0 0.051 12.6 16.4 2.9 1 1 1 2 2 2 0 Autophagy protein Apg6 Kinetocho_Slk19 PF12709.2 ESA11710.1 - 9.4 6.3 32.6 0.85 9.7 3.1 4.8 4 1 1 5 5 5 0 Central kinetochore-associated RasGAP_C PF03836.10 ESA11711.1 - 4.7e-09 36.0 0.5 5.5e-09 35.8 0.3 1.2 1 0 0 1 1 1 1 RasGAP C-terminus Pkinase_Tyr PF07714.12 ESA11712.1 - 5.2e-71 238.7 0.0 1.2e-38 132.6 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA11712.1 - 2.1e-65 220.4 2.7 5.3e-39 133.9 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain APH PF01636.18 ESA11712.1 - 1.9e-05 24.5 0.0 6.5e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA11712.1 - 0.00016 20.9 1.7 0.0058 15.8 0.0 2.6 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA11712.1 - 0.00016 20.7 0.7 0.23 10.5 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA11712.1 - 0.00027 20.3 0.5 0.033 13.5 0.0 2.4 2 0 0 2 2 2 2 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA11712.1 - 0.0088 15.4 2.2 0.027 13.8 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Sp100 PF03172.8 ESA11712.1 - 0.024 14.5 4.0 1.3 9.0 0.0 3.6 3 1 1 4 4 4 0 Sp100 domain MULE PF10551.4 ESA11713.1 - 2e-08 34.2 0.1 6.7e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.13 ESA11713.1 - 0.00028 19.5 0.1 0.00043 18.9 0.0 1.3 1 0 0 1 1 1 1 Transposase, Mutator family DDE_Tnp_ISL3 PF01610.12 ESA11713.1 - 0.012 15.2 3.0 0.033 13.7 2.1 1.8 1 1 0 1 1 1 0 Transposase DDE_Tnp_IS240 PF13610.1 ESA11713.1 - 0.066 13.1 0.5 0.41 10.6 0.0 2.3 2 1 1 3 3 3 0 DDE domain ABC2_membrane_3 PF12698.2 ESA11713.1 - 1.4 7.8 5.2 4.5 6.2 3.6 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Cu-binding_MopE PF11617.3 ESA11714.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein metal binding site Pkinase_Tyr PF07714.12 ESA11714.1 - 0.14 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase ARHGEF5_35 PF15441.1 ESA11714.1 - 0.16 10.7 0.0 0.21 10.3 0.0 1.0 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 Pkinase_Tyr PF07714.12 ESA11716.1 - 1.4e-31 109.4 0.3 1.9e-31 109.0 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11716.1 - 1.3e-22 80.1 3.5 2.9e-22 79.0 2.5 1.5 1 1 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11716.1 - 0.0011 19.5 0.0 0.0019 18.7 0.0 1.4 1 0 0 1 1 1 1 Sel1 repeat Kinase-like PF14531.1 ESA11716.1 - 0.0024 16.8 0.0 0.0035 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF1617 PF07761.7 ESA11717.1 - 0.0091 16.0 0.2 0.0093 16.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1617) DUF2681 PF10883.3 ESA11717.1 - 0.24 11.5 2.4 0.29 11.3 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF244 PF03112.9 ESA11717.1 - 0.26 10.7 1.7 0.28 10.6 1.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF DUF4355 PF14265.1 ESA11717.1 - 0.51 10.2 5.8 0.59 10.0 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) RabGAP-TBC PF00566.13 ESA11719.1 - 3.9e-34 118.0 4.0 2.9e-29 102.0 0.0 2.5 2 1 0 2 2 2 2 Rab-GTPase-TBC domain TPR_11 PF13414.1 ESA11720.1 - 9.3e-17 60.4 6.0 5.8e-12 45.0 0.1 2.8 3 0 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 ESA11720.1 - 1.4e-11 43.4 5.8 0.0012 18.3 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA11720.1 - 1.3e-09 37.2 0.7 0.0053 16.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA11720.1 - 8.5e-06 25.1 0.4 0.02 14.6 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat UBA PF00627.26 ESA11720.1 - 3.5e-05 23.5 0.0 9.9e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain DnaJ PF00226.26 ESA11720.1 - 0.00015 21.4 0.1 0.00077 19.1 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain TPR_12 PF13424.1 ESA11720.1 - 0.00038 20.3 4.3 0.021 14.7 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA11720.1 - 0.0093 16.3 0.4 0.039 14.4 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA11720.1 - 0.016 15.8 0.2 1.5 9.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA11720.1 - 0.17 12.5 0.8 7.6 7.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RasGEF_N PF00618.15 ESA11721.1 - 0.0052 16.8 0.7 0.0073 16.3 0.5 1.2 1 0 0 1 1 1 1 RasGEF N-terminal motif PSD4 PF07631.6 ESA11722.1 - 0.05 13.9 0.9 0.05 13.9 0.6 4.8 3 1 3 6 6 6 0 Protein of unknown function (DUF1592) US2 PF02476.10 ESA11722.1 - 0.13 12.7 0.4 0.37 11.2 0.3 1.8 1 0 0 1 1 1 0 US2 family ArdA PF07275.6 ESA11722.1 - 0.2 11.8 45.0 0.12 12.6 2.7 5.9 1 1 3 6 6 6 0 Antirestriction protein (ArdA) Zip PF02535.17 ESA11722.1 - 0.71 8.8 4.8 1.1 8.2 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter HrcA PF01628.16 ESA11722.1 - 1 8.9 9.6 0.33 10.5 0.6 3.6 2 2 1 4 4 4 0 HrcA protein C terminal domain DUF2201_N PF13203.1 ESA11722.1 - 1.9 7.6 9.0 3 6.9 6.2 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4175 PF13779.1 ESA11722.1 - 3.8 5.1 5.7 5.1 4.6 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PRK PF00485.13 ESA11723.1 - 3.9e-07 29.8 2.8 0.00044 19.8 1.2 3.3 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 ESA11723.1 - 2.6e-06 27.7 8.4 0.035 14.4 3.7 2.9 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.1 ESA11723.1 - 0.00022 22.0 8.3 0.0024 18.6 0.0 2.7 1 1 1 3 3 3 1 AAA domain DUF2722 PF10846.3 ESA11723.1 - 0.021 13.8 4.7 0.026 13.5 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Vhr1 PF04001.8 ESA11723.1 - 0.041 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Transcription factor Vhr1 AAA_28 PF13521.1 ESA11723.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ORF6C PF10552.4 ESA11723.1 - 0.2 11.3 6.9 0.14 11.8 1.1 2.4 2 0 0 2 2 2 0 ORF6C domain RP-C_C PF11800.3 ESA11723.1 - 0.26 10.9 2.6 0.45 10.1 1.8 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.17 ESA11723.1 - 0.27 10.1 2.6 0.35 9.8 1.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.7 ESA11723.1 - 0.34 9.9 7.7 0.57 9.2 5.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2457 PF10446.4 ESA11723.1 - 0.54 8.9 10.2 0.76 8.4 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop25 PF09805.4 ESA11723.1 - 1.2 9.1 10.2 0.21 11.6 4.7 1.5 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Pkinase_Tyr PF07714.12 ESA11724.1 - 1.5e-25 89.7 0.4 5.3e-25 87.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11724.1 - 1.5e-24 86.5 0.9 2.3e-24 85.9 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA11724.1 - 0.016 14.2 0.1 0.029 13.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF1G PF00647.14 ESA11724.1 - 0.19 11.4 3.9 0.15 11.7 0.9 2.2 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain zf-C3HC PF07967.8 ESA11726.1 - 0.085 12.6 0.0 0.085 12.6 0.0 1.2 1 0 0 1 1 1 0 C3HC zinc finger-like FBA_2 PF07735.12 ESA11727.1 - 0.067 13.0 1.3 0.096 12.5 0.4 1.8 2 0 0 2 2 2 0 F-box associated zf-Paramyx-P PF13008.2 ESA11730.1 - 2.4 7.3 6.7 5.6 6.2 4.7 1.5 1 0 0 1 1 1 0 Zinc-binding domain of Paramyxoviridae V protein FBD PF08387.5 ESA11731.1 - 0.018 14.4 0.5 0.05 13.0 0.1 2.0 2 0 0 2 2 2 0 FBD Pkinase_Tyr PF07714.12 ESA11733.1 - 3.8e-29 101.5 0.2 5e-29 101.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11733.1 - 1.7e-27 96.1 0.6 2.5e-27 95.6 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11733.1 - 0.0024 18.4 4.7 0.0044 17.6 0.7 2.8 3 0 0 3 3 3 1 Sel1 repeat Kdo PF06293.9 ESA11733.1 - 0.023 13.7 0.1 0.042 12.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CHCH PF06747.8 ESA11733.1 - 0.03 14.2 0.4 0.03 14.2 0.3 1.8 2 0 0 2 2 2 0 CHCH domain TRL PF13146.1 ESA11733.1 - 0.088 12.8 0.1 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 TRL-like protein family Pkinase_Tyr PF07714.12 ESA11734.1 - 3.3e-29 101.7 0.1 4.2e-29 101.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11734.1 - 2e-28 99.2 0.1 2.7e-28 98.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA11734.1 - 0.034 13.2 0.1 0.054 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Dimer_Tnp_hAT PF05699.9 ESA11736.1 - 2.8e-15 55.7 0.2 5.8e-15 54.6 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ribosomal_L25p PF01386.14 ESA11741.1 - 0.018 15.1 0.1 0.037 14.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal L25p family zf-AD PF07776.10 ESA11743.1 - 0.12 12.3 2.6 0.24 11.4 1.8 1.6 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Ion_trans PF00520.26 ESA11744.1 - 0.0015 17.7 13.4 0.012 14.8 9.3 2.0 1 1 0 1 1 1 1 Ion transport protein Imm22 PF15592.1 ESA11744.1 - 0.012 15.9 1.0 0.11 12.7 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 22 DUF3357 PF11837.3 ESA11744.1 - 0.034 13.9 0.2 0.33 10.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) GntR PF00392.16 ESA11744.1 - 0.075 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF3860 PF12976.2 ESA11744.1 - 0.11 12.3 0.4 0.19 11.5 0.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) TRP PF06011.7 ESA11744.1 - 0.25 9.8 6.4 1.1 7.7 4.4 1.8 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel ATP-synt_8 PF00895.15 ESA11744.1 - 0.82 9.9 7.5 7.9 6.7 1.3 2.7 2 0 0 2 2 2 0 ATP synthase protein 8 TLD PF07534.11 ESA11745.1 - 9.4e-13 48.3 2.8 2.4e-12 47.0 2.0 1.6 1 1 0 1 1 1 1 TLD GSu_C4xC__C2xCH PF09698.5 ESA11745.1 - 0.28 11.3 0.2 0.28 11.3 0.2 2.1 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) zf-C3HC4_3 PF13920.1 ESA11746.1 - 0.00059 19.4 8.0 0.00059 19.4 5.6 3.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA11746.1 - 0.43 10.2 24.2 0.039 13.5 7.4 3.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ins145_P3_rec PF08709.6 ESA11747.1 - 0.0011 18.0 0.1 0.003 16.6 0.0 1.7 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA11747.1 - 0.0014 18.2 0.3 0.63 9.5 0.0 3.0 2 2 1 3 3 3 2 MIR domain UBN2 PF14223.1 ESA11747.1 - 0.038 13.7 0.7 0.07 12.9 0.5 1.4 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type Pkinase PF00069.20 ESA11749.1 - 1.5e-37 129.1 0.1 3e-37 128.1 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11749.1 - 1.9e-37 128.7 0.0 2.8e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA11749.1 - 0.0098 15.6 0.1 0.015 15.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA11749.1 - 0.069 12.2 0.1 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Turandot PF07240.6 ESA11749.1 - 0.11 11.9 0.3 0.25 10.8 0.2 1.6 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot Cas1_AcylT PF07779.7 ESA11750.1 - 4.1e-147 490.5 42.0 7.7e-147 489.6 29.1 1.3 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p PC-Esterase PF13839.1 ESA11750.1 - 1.1e-35 123.6 0.0 1.9e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Nicastrin PF05450.10 ESA11751.1 - 2.9e-37 128.1 0.1 1.3e-35 122.7 0.1 2.4 1 1 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.12 ESA11751.1 - 2.3e-05 24.2 0.0 3.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 WVELL PF14043.1 ESA11751.1 - 0.25 11.0 0.2 0.48 10.0 0.1 1.4 1 0 0 1 1 1 0 WVELL protein GAS PF13851.1 ESA11752.1 - 0.057 12.6 0.1 0.096 11.8 0.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Me-amine-dh_H PF06433.6 ESA11753.1 - 0.13 10.8 0.0 0.14 10.7 0.0 1.0 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Potassium_chann PF11404.3 ESA11754.1 - 0.059 13.1 0.3 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 Potassium voltage-gated channel Toxin_2 PF00451.14 ESA11756.1 - 0.21 11.7 0.5 0.21 11.7 0.4 2.1 3 0 0 3 3 3 0 Scorpion short toxin, BmKK2 MinC_N PF05209.8 ESA11762.1 - 0.0007 19.3 3.5 0.16 11.7 0.0 2.6 2 0 0 2 2 2 2 Septum formation inhibitor MinC, N-terminal domain DJ-1_PfpI PF01965.19 ESA11762.1 - 0.015 14.8 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family RSD-2 PF07547.8 ESA11762.1 - 0.038 14.1 1.5 0.11 12.6 0.0 2.6 3 0 0 3 3 3 0 RSD-2 N-terminal domain IncA PF04156.9 ESA11762.1 - 1.5 8.3 17.8 3.2 7.3 12.3 1.5 1 0 0 1 1 1 0 IncA protein HSP70 PF00012.15 ESA11763.1 - 0.003 15.5 0.1 0.012 13.5 0.0 1.9 1 1 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.15 ESA11763.1 - 0.026 13.8 0.0 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family AAA-ATPase_like PF09820.4 ESA11764.1 - 2.7e-38 131.7 1.1 3.9e-38 131.2 0.8 1.2 1 0 0 1 1 1 1 Predicted AAA-ATPase TLD PF07534.11 ESA11765.1 - 2.2e-05 24.4 1.6 2.3e-05 24.4 0.3 1.8 2 1 0 2 2 2 1 TLD HSP70 PF00012.15 ESA11766.1 - 0.00016 19.7 0.0 0.00016 19.7 0.0 2.6 3 0 0 3 3 3 1 Hsp70 protein MreB_Mbl PF06723.8 ESA11766.1 - 0.0016 17.0 0.0 0.21 10.1 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein CDC45 PF02724.9 ESA11766.1 - 0.14 10.1 8.9 0.21 9.5 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M22 PF00814.20 ESA11766.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Glycoprotease family Gag_spuma PF03276.9 ESA11768.1 - 0.22 9.8 0.0 0.29 9.4 0.0 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Cu-oxidase_3 PF07732.10 ESA11769.1 - 1e-40 138.1 0.7 3.8e-40 136.2 0.5 2.0 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.17 ESA11769.1 - 9.5e-32 110.0 0.1 8.9e-29 100.4 0.0 2.9 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA11769.1 - 4.5e-29 100.7 4.1 5.1e-22 77.8 0.0 4.3 2 1 0 2 2 2 2 Multicopper oxidase TF_Zn_Ribbon PF08271.7 ESA11772.1 - 0.0016 17.6 5.4 0.3 10.4 0.1 3.8 3 0 0 3 3 3 2 TFIIB zinc-binding DUF4413 PF14372.1 ESA11772.1 - 0.0031 17.4 4.8 1.1 9.3 0.2 3.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4413) TraT PF05818.7 ESA11772.1 - 0.013 14.9 0.3 0.046 13.1 0.0 2.0 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF1355 PF07090.6 ESA11772.1 - 0.015 14.7 0.0 3.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1355) Lpp-LpqN PF10738.4 ESA11773.1 - 0.024 13.9 0.6 0.033 13.4 0.4 1.2 1 0 0 1 1 1 0 Probable lipoprotein LpqN Methyltransf_11 PF08241.7 ESA11774.1 - 1.2e-08 35.3 0.0 3.8e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA11774.1 - 2e-07 30.7 0.2 1.3e-06 28.0 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA11774.1 - 0.00055 19.6 0.0 0.001 18.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA11774.1 - 0.0018 18.8 0.0 0.015 15.8 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA11774.1 - 0.024 15.1 0.0 0.068 13.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Pkinase_Tyr PF07714.12 ESA11775.1 - 4.6e-16 58.6 0.0 7.2e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11775.1 - 1.6e-10 40.6 0.0 2.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain zinc-ribbons_6 PF07191.7 ESA11775.1 - 0.056 13.2 1.4 0.11 12.3 1.0 1.4 1 0 0 1 1 1 0 zinc-ribbons MACPF PF01823.14 ESA11777.1 - 2.8e-12 46.7 3.5 5.2e-12 45.9 2.4 1.4 1 0 0 1 1 1 1 MAC/Perforin domain SHP PF03579.8 ESA11778.1 - 0.085 12.2 6.9 0.25 10.7 0.2 2.2 2 0 0 2 2 2 0 Small hydrophobic protein DUF2238 PF09997.4 ESA11778.1 - 1.7 8.0 4.5 3.9 6.8 2.9 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2238) MFS_1 PF07690.11 ESA11779.1 - 2.4e-35 121.9 56.0 1.1e-26 93.4 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA11779.1 - 8.9e-07 27.8 7.1 8.9e-07 27.8 4.9 3.9 1 1 2 3 3 3 2 Sugar (and other) transporter ATG22 PF11700.3 ESA11779.1 - 6.4e-06 24.9 29.5 9.8e-05 21.0 3.3 2.7 4 0 0 4 4 4 2 Vacuole effluxer Atg22 like DUF4234 PF14018.1 ESA11779.1 - 0.13 12.0 11.6 0.75 9.5 0.2 4.1 4 1 0 4 4 4 0 Domain of unknown function (DUF4234) DUF912 PF06024.7 ESA11779.1 - 2 8.5 4.9 42 4.2 0.1 3.4 3 1 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MFS_3 PF05977.8 ESA11779.1 - 2.3 6.2 17.1 0.11 10.5 2.4 2.5 1 1 0 2 2 2 0 Transmembrane secretion effector RdgC PF04381.7 ESA11780.1 - 0.082 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative exonuclease, RdgC Pox_D2 PF04701.8 ESA11781.1 - 0.0066 16.4 0.2 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 Pox virus D2 protein Adaptin_binding PF10199.4 ESA11781.1 - 0.39 11.0 3.8 0.94 9.7 2.0 2.1 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Tox-URI2 PF15653.1 ESA11782.1 - 0.046 13.9 0.1 0.095 12.9 0.1 1.6 1 0 0 1 1 1 0 URI fold toxin 2 Flu_NS1 PF00600.14 ESA11782.1 - 0.05 12.7 0.1 0.1 11.6 0.0 1.7 1 1 0 1 1 1 0 Influenza non-structural protein (NS1) SAM_1 PF00536.25 ESA11783.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Striatin PF08232.7 ESA11783.1 - 0.018 15.3 1.6 0.031 14.5 1.1 1.3 1 0 0 1 1 1 0 Striatin family DUF972 PF06156.8 ESA11783.1 - 0.061 13.6 0.7 0.12 12.7 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Ste50p-SAM PF09235.5 ESA11783.1 - 0.065 13.2 0.1 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Ste50p, sterile alpha motif RBD-FIP PF09457.5 ESA11783.1 - 9.6 6.0 7.4 2 8.2 1.4 2.5 2 0 0 2 2 2 0 FIP domain Y1_Tnp PF01797.11 ESA11784.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Transposase IS200 like DUF939_C PF11728.3 ESA11784.1 - 0.19 11.5 1.9 0.25 11.1 0.2 1.7 2 0 0 2 2 2 0 DUF939 C-terminal domain Rep_2 PF01719.12 ESA11786.1 - 0.012 15.1 0.9 0.012 15.1 0.6 1.1 1 0 0 1 1 1 0 Plasmid replication protein Endonuclea_NS_2 PF13930.1 ESA11786.1 - 0.012 15.6 0.3 0.015 15.3 0.2 1.2 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease Mt_ATP-synt_B PF05405.9 ESA11786.1 - 0.015 14.7 3.9 0.02 14.3 2.7 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF416 PF04222.7 ESA11786.1 - 0.026 13.6 0.4 0.038 13.1 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF416) Atg14 PF10186.4 ESA11786.1 - 0.14 11.0 4.6 0.16 10.9 3.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3595 PF12166.3 ESA11787.1 - 0.16 10.7 1.3 0.16 10.7 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) SR-25 PF10500.4 ESA11788.1 - 0.004 16.6 25.3 0.004 16.6 17.5 2.3 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein SlyX PF04102.7 ESA11788.1 - 0.12 12.7 3.4 0.14 12.5 0.5 2.4 2 0 0 2 2 2 0 SlyX Mem_trans PF03547.13 ESA11788.1 - 0.28 9.4 4.5 0.36 9.0 3.1 1.2 1 0 0 1 1 1 0 Membrane transport protein HORMA PF02301.13 ESA11789.1 - 2.2e-29 102.4 0.3 2.4e-29 102.3 0.2 1.0 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 ESA11789.1 - 0.028 13.8 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Autophagy-related protein 13 Aha1_N PF09229.6 ESA11790.1 - 0.08 12.7 0.0 0.093 12.5 0.0 1.1 1 0 0 1 1 1 0 Activator of Hsp90 ATPase, N-terminal PD40 PF07676.7 ESA11791.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Wx5_PLAF3D7 PF09688.5 ESA11792.1 - 0.065 13.1 0.1 0.077 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) DZR PF12773.2 ESA11795.1 - 0.0079 15.9 1.2 0.012 15.4 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon PP_kinase PF02503.12 ESA11795.1 - 0.067 12.6 0.4 0.074 12.5 0.3 1.1 1 0 0 1 1 1 0 Polyphosphate kinase middle domain eIF-5_eIF-2B PF01873.12 ESA11795.1 - 0.14 11.7 2.9 0.23 11.1 1.6 1.7 1 1 0 1 1 1 0 Domain found in IF2B/IF5 LRR_6 PF13516.1 ESA11796.1 - 1.1e-06 28.1 2.0 0.12 12.5 0.0 6.1 7 0 0 7 7 7 2 Leucine Rich repeat HSP20 PF00011.16 ESA11797.1 - 0.021 14.7 0.1 0.025 14.4 0.1 1.2 1 0 0 1 1 1 0 Hsp20/alpha crystallin family DUF1108 PF06531.6 ESA11797.1 - 0.041 14.0 0.7 0.049 13.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) ubiquitin PF00240.18 ESA11801.1 - 3.8e-10 39.0 0.0 7.5e-10 38.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA11801.1 - 1.5e-07 31.0 0.0 2.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF3990 PF13151.1 ESA11801.1 - 0.014 14.7 0.2 0.044 13.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) PARP PF00644.15 ESA11801.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain zf-MYND PF01753.13 ESA11803.1 - 9.8e-08 31.7 16.6 1.8e-07 30.8 11.5 1.5 1 0 0 1 1 1 1 MYND finger Mucin PF01456.12 ESA11803.1 - 0.64 9.7 10.5 4.3 7.1 3.7 2.6 2 1 0 2 2 2 0 Mucin-like glycoprotein DASH_Spc34 PF08657.5 ESA11804.1 - 1.3e-05 25.0 12.6 3.9e-05 23.4 5.6 3.4 3 1 1 4 4 4 2 DASH complex subunit Spc34 DUF2669 PF10876.3 ESA11804.1 - 0.17 11.5 1.2 16 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2669) SPT16 PF08644.6 ESA11804.1 - 0.31 10.8 8.6 0.18 11.6 1.2 2.9 2 1 1 3 3 3 0 FACT complex subunit (SPT16/CDC68) MerR-DNA-bind PF09278.6 ESA11804.1 - 5.6 7.4 9.4 9.5 6.6 1.7 2.9 2 0 0 2 2 2 0 MerR, DNA binding Ldh_1_C PF02866.13 ESA11805.1 - 4.7e-46 156.6 0.0 6.3e-46 156.2 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 ESA11805.1 - 5.9e-44 149.3 0.2 2.1e-43 147.5 0.1 1.8 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.11 ESA11805.1 - 0.013 14.8 0.1 0.089 12.0 0.0 2.3 2 1 1 3 3 3 0 Family 4 glycosyl hydrolase 3Beta_HSD PF01073.14 ESA11805.1 - 0.13 10.8 0.0 0.31 9.7 0.0 1.6 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Ins145_P3_rec PF08709.6 ESA11806.1 - 2.7e-07 29.8 0.0 6.5e-07 28.6 0.0 1.6 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA11806.1 - 0.01 15.3 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 0 MIR domain NDUF_B7 PF05676.8 ESA11806.1 - 0.57 9.6 3.5 0.47 9.9 0.2 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) AAA PF00004.24 ESA11807.1 - 8.6e-19 68.0 0.0 1.8e-18 67.0 0.0 1.5 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA11807.1 - 5.3e-07 30.4 0.2 2.1e-06 28.5 0.1 1.8 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA11807.1 - 8.7e-05 22.5 0.8 0.00079 19.4 0.1 2.3 1 1 2 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 ESA11807.1 - 0.00022 21.3 0.7 0.0096 16.0 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA11807.1 - 0.00043 19.9 0.1 0.002 17.8 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_2 PF07724.9 ESA11807.1 - 0.00054 19.9 0.0 0.0015 18.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zot PF05707.7 ESA11807.1 - 0.00096 18.6 0.1 0.069 12.6 0.0 2.2 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_18 PF13238.1 ESA11807.1 - 0.0012 19.1 0.2 0.0025 18.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESA11807.1 - 0.0041 16.8 0.0 0.008 15.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESA11807.1 - 0.011 14.9 0.4 0.039 13.1 0.1 1.9 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 ESA11807.1 - 0.02 13.9 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus NTPase_1 PF03266.10 ESA11807.1 - 0.026 14.2 0.2 3.1 7.4 0.0 2.3 1 1 1 2 2 2 0 NTPase AAA_33 PF13671.1 ESA11807.1 - 0.045 13.6 0.0 0.068 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Vps36_ESCRT-II PF11605.3 ESA11807.1 - 0.05 13.4 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 IstB_IS21 PF01695.12 ESA11807.1 - 0.07 12.5 0.4 0.15 11.4 0.1 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein TIP49 PF06068.8 ESA11807.1 - 0.073 11.7 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus DUF3121 PF11319.3 ESA11807.1 - 0.075 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3121) AAA_11 PF13086.1 ESA11807.1 - 0.077 12.5 0.0 0.086 12.4 0.0 1.3 1 1 0 1 1 1 0 AAA domain KaiC PF06745.8 ESA11807.1 - 0.32 10.0 1.4 6.7 5.7 0.1 2.1 1 1 1 2 2 2 0 KaiC Lactamase_B PF00753.22 ESA11812.1 - 0.00018 21.2 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESA11812.1 - 0.21 11.1 1.2 4.1 6.8 0.0 2.1 1 1 0 2 2 2 0 Beta-lactamase superfamily domain Mur_ligase_M PF08245.7 ESA11813.1 - 3.2e-12 46.9 0.0 6.1e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 ESA11813.1 - 0.14 12.1 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Sigma70_r4_2 PF08281.7 ESA11815.1 - 0.027 13.9 0.0 4.2 6.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 PEPCK_ATP PF01293.15 ESA11816.1 - 2.5e-222 738.4 0.0 2.9e-222 738.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.1 ESA11816.1 - 0.2 11.6 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain CENP-L PF13092.1 ESA11817.1 - 0.052 13.3 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 SMN PF06003.7 ESA11819.1 - 0.062 12.3 1.2 0.11 11.5 0.1 2.0 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) RCC1 PF00415.13 ESA11821.1 - 3.4e-43 145.6 5.5 8.1e-10 38.7 0.0 7.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESA11821.1 - 3e-37 125.4 19.0 3.6e-10 39.1 1.2 5.9 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat NmrA PF05368.8 ESA11822.1 - 5e-56 189.5 0.3 6.1e-56 189.2 0.2 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA11822.1 - 1.8e-15 57.4 0.0 2.5e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA11822.1 - 2.9e-10 39.3 0.1 1.9e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ESA11822.1 - 9.4e-06 25.2 0.1 4.7e-05 22.9 0.0 2.1 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family KR PF08659.5 ESA11822.1 - 1.6e-05 24.6 0.1 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 ESA11822.1 - 2.9e-05 24.0 0.1 5.7e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 ESA11822.1 - 0.00049 19.2 0.2 0.00077 18.5 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase TrkA_N PF02254.13 ESA11822.1 - 0.0027 17.6 0.0 0.0049 16.8 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.15 ESA11822.1 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.15 ESA11822.1 - 0.013 15.4 0.1 0.034 14.0 0.1 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 ESA11822.1 - 0.064 12.1 0.0 0.18 10.6 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein DUF975 PF06161.6 ESA11823.1 - 0.22 11.2 9.8 0.017 14.8 3.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF975) MARVEL PF01284.18 ESA11823.1 - 10 5.9 14.5 77 3.0 10.0 2.1 1 1 0 1 1 1 0 Membrane-associating domain MARVEL PF01284.18 ESA11824.1 - 0.0076 16.0 8.1 0.009 15.8 5.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF3365 PF11845.3 ESA11825.1 - 0.2 11.5 4.4 0.24 11.2 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) QueC PF06508.8 ESA11825.1 - 0.2 10.9 2.2 0.23 10.7 1.5 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Paramyxo_ncap PF00973.14 ESA11825.1 - 3.2 6.3 9.9 3.4 6.2 6.9 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein zf-RING_5 PF14634.1 ESA11826.1 - 1.1e-06 28.2 7.6 1.8e-06 27.5 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA11826.1 - 1.2e-05 24.8 7.3 2.3e-05 23.9 5.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA11826.1 - 4.4e-05 23.0 9.0 0.00044 19.8 5.9 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA11826.1 - 0.00026 20.9 9.3 0.00092 19.1 6.4 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA11826.1 - 0.00028 20.6 7.2 0.00051 19.8 5.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 ESA11826.1 - 0.00038 20.2 7.9 0.00096 18.9 5.6 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.7 ESA11826.1 - 0.00092 18.4 0.2 0.0012 18.0 0.2 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_UBOX PF13445.1 ESA11826.1 - 0.0017 18.0 2.9 0.004 16.8 2.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.1 ESA11826.1 - 0.002 17.5 5.4 0.0052 16.3 3.7 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 ESA11826.1 - 0.0064 16.2 2.0 0.011 15.5 1.4 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein FYVE_2 PF02318.11 ESA11826.1 - 0.014 15.2 2.4 0.022 14.6 1.6 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger zf-UBP PF02148.14 ESA11826.1 - 0.04 14.0 3.1 0.04 14.0 2.1 2.3 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_4 PF14570.1 ESA11826.1 - 0.17 11.4 9.1 0.67 9.5 6.3 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain ArfGap PF01412.13 ESA11826.1 - 0.28 10.9 9.0 0.031 14.0 2.8 1.9 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf DZR PF12773.2 ESA11826.1 - 0.29 10.9 7.0 16 5.4 5.8 2.3 1 1 1 2 2 2 0 Double zinc ribbon PHD PF00628.24 ESA11826.1 - 0.32 10.7 11.5 3.5 7.3 0.2 2.3 2 0 0 2 2 2 0 PHD-finger Zn_Tnp_IS1595 PF12760.2 ESA11826.1 - 0.5 10.2 5.7 0.91 9.3 4.0 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-CHY PF05495.7 ESA11826.1 - 0.52 10.5 6.9 2.2 8.5 4.9 1.9 1 1 1 2 2 2 0 CHY zinc finger LIM PF00412.17 ESA11826.1 - 0.93 9.6 6.3 5 7.2 1.4 2.4 1 1 1 2 2 2 0 LIM domain TerY-C PF15616.1 ESA11826.1 - 1.6 8.6 6.7 4.8 7.1 4.7 1.8 1 1 0 1 1 1 0 TerY-C metal binding domain FYVE PF01363.16 ESA11826.1 - 2.6 7.9 8.6 24 4.9 6.1 2.4 1 1 1 2 2 2 0 FYVE zinc finger HypA PF01155.14 ESA11826.1 - 3.8 7.2 6.3 12 5.6 4.3 1.8 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family C1_4 PF07975.7 ESA11826.1 - 4.6 7.3 12.0 2 8.4 0.9 2.5 2 0 0 2 2 2 0 TFIIH C1-like domain Med27 PF11571.3 ESA11826.1 - 5.3 7.2 7.9 1.3 9.1 1.2 2.7 1 1 2 3 3 3 0 Mediator complex subunit 27 zf-H2C2_2 PF13465.1 ESA11826.1 - 6.6 7.2 8.5 24 5.4 5.9 2.1 1 1 0 1 1 1 0 Zinc-finger double domain Lactamase_B PF00753.22 ESA11827.1 - 3.6e-07 30.0 0.0 6.3e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESA11827.1 - 9.2e-05 22.0 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BTB PF00651.26 ESA11828.1 - 5.6e-16 58.5 0.1 1.4e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA11828.1 - 3.4e-13 49.7 1.3 7.7e-13 48.6 0.9 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA11828.1 - 2e-05 24.3 4.3 0.00021 21.1 1.5 2.9 2 1 0 2 2 2 1 BTB And C-terminal Kelch Dimer_Tnp_hAT PF05699.9 ESA11831.1 - 3.1e-14 52.3 0.1 3.3e-14 52.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region FimH_man-bind PF09160.5 ESA11832.1 - 0.066 13.0 0.0 0.075 12.8 0.0 1.1 1 0 0 1 1 1 0 FimH, mannose binding DUF3969 PF13108.1 ESA11835.1 - 0.0015 18.1 1.2 0.0019 17.8 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3969) PLDc_2 PF13091.1 ESA11837.1 - 5.4e-11 42.3 0.5 1.2e-07 31.5 0.1 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 ESA11837.1 - 6.4e-09 35.3 0.3 1.3e-08 34.3 0.2 1.5 1 0 0 1 1 1 1 Phospholipase D Active site motif Methyltransf_11 PF08241.7 ESA11838.1 - 1.4e-10 41.5 0.0 2.6e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA11838.1 - 4.7e-10 39.4 0.0 7.4e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA11838.1 - 1.3e-09 38.3 0.0 4.2e-09 36.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA11838.1 - 4.4e-09 36.0 0.0 0.00018 21.1 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 ESA11838.1 - 2.3e-06 28.1 0.1 3.2e-05 24.4 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA11838.1 - 1e-05 24.8 0.0 9.7e-05 21.5 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA11838.1 - 7.1e-05 21.9 0.0 0.00013 21.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA11838.1 - 0.00013 22.3 0.0 0.0011 19.4 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESA11838.1 - 0.00023 20.4 0.0 0.00045 19.4 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 ESA11838.1 - 0.0022 17.9 0.0 0.0053 16.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA11838.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase MetW PF07021.7 ESA11838.1 - 0.012 14.9 0.0 0.096 12.0 0.0 2.3 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.6 ESA11838.1 - 0.061 12.0 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.15 ESA11838.1 - 0.074 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.11 ESA11838.1 - 0.16 10.2 0.2 1.4 7.1 0.0 2.0 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Tim17 PF02466.14 ESA11839.1 - 2.5e-27 95.4 0.1 3.6e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Ribosomal_L10 PF00466.15 ESA11840.1 - 1.9e-05 24.5 0.0 3.2e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L10 GSH_synthase PF03199.10 ESA11840.1 - 0.028 14.5 0.1 0.042 13.9 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic glutathione synthase DUF423 PF04241.10 ESA11841.1 - 1e-22 79.8 0.3 1.5e-22 79.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF4536 PF15055.1 ESA11841.1 - 0.049 13.7 1.8 0.065 13.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) DnaJ PF00226.26 ESA11842.1 - 1.1e-26 92.3 6.2 1.7e-26 91.6 4.3 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESA11842.1 - 4.2e-22 77.8 0.7 2.1e-19 69.2 0.1 2.7 2 1 0 2 2 2 2 DnaJ C terminal domain TPR_2 PF07719.12 ESA11847.1 - 7e-05 22.4 6.3 0.16 11.9 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA11847.1 - 0.0001 22.8 0.0 0.00027 21.4 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA11847.1 - 0.0002 20.9 6.2 0.00022 20.7 1.2 2.5 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.1 ESA11847.1 - 0.00046 19.7 9.7 0.039 13.7 2.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA11847.1 - 0.007 16.6 2.4 0.039 14.3 0.4 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11847.1 - 0.031 14.4 3.2 0.068 13.3 0.3 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA11847.1 - 0.34 10.5 0.1 0.34 10.5 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat GerPC PF10737.4 ESA11849.1 - 0.013 15.2 0.6 0.018 14.8 0.4 1.2 1 0 0 1 1 1 0 Spore germination protein GerPC Pkinase_Tyr PF07714.12 ESA11850.1 - 6.6e-06 25.3 0.0 1.1e-05 24.6 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11850.1 - 0.00014 21.1 0.5 0.0002 20.6 0.3 1.3 1 1 0 1 1 1 1 Protein kinase domain TIR PF01582.15 ESA11851.1 - 0.0012 18.3 3.2 0.0073 15.7 0.3 2.1 1 1 1 2 2 2 2 TIR domain WRW PF10206.4 ESA11851.1 - 0.047 13.7 0.4 0.14 12.2 0.1 1.8 2 0 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f APCDDC PF14921.1 ESA11852.1 - 0.095 12.0 4.9 0.76 9.0 0.2 2.2 2 0 0 2 2 2 0 Adenomatosis polyposis coli down-regulated 1 HnRNPA1 PF11627.3 ESA11852.1 - 0.12 12.6 0.6 0.23 11.6 0.4 1.5 1 0 0 1 1 1 0 Nuclear factor hnRNPA1 DUF745 PF05335.8 ESA11852.1 - 0.55 9.7 3.1 0.82 9.1 1.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) zf-CCHC_4 PF14392.1 ESA11854.1 - 0.00081 19.0 0.4 0.0016 18.0 0.2 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 ESA11854.1 - 0.049 13.5 4.3 0.049 13.5 3.0 1.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 ESA11854.1 - 0.056 13.1 2.2 0.056 13.1 1.6 2.0 2 0 0 2 2 2 0 Zinc knuckle DUF2457 PF10446.4 ESA11854.1 - 0.25 10.0 11.1 0.28 9.8 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) YL1 PF05764.8 ESA11854.1 - 0.59 9.6 6.9 0.77 9.3 4.8 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Destabilase PF05497.7 ESA11855.1 - 0.072 13.1 0.0 0.074 13.1 0.0 1.0 1 0 0 1 1 1 0 Destabilase HTH_23 PF13384.1 ESA11855.1 - 0.077 12.6 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain Pkinase PF00069.20 ESA11856.1 - 1.7e-12 47.0 5.3 4.7e-11 42.3 3.7 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11856.1 - 8.9e-11 41.3 0.1 2.7e-09 36.4 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Tnp_zf-ribbon_2 PF13842.1 ESA11856.1 - 0.013 15.9 3.2 0.027 14.8 2.2 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon HypA PF01155.14 ESA11856.1 - 0.066 12.9 0.3 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family F-box-like PF12937.2 ESA11857.1 - 0.0023 17.5 1.3 0.0039 16.8 0.2 2.0 2 0 0 2 2 2 1 F-box-like Acetyltransf_1 PF00583.19 ESA11858.1 - 1.3e-05 25.1 0.2 3e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA11858.1 - 0.00037 20.5 0.1 0.0005 20.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Astacin PF01400.19 ESA11859.1 - 4.1e-42 143.7 0.2 6.1e-42 143.1 0.2 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) BTB PF00651.26 ESA11860.1 - 1.6e-17 63.4 0.9 3.9e-17 62.2 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA11860.1 - 3.6e-15 56.1 0.6 3.3e-14 53.0 0.2 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA11860.1 - 4.8e-06 26.3 1.6 3.7e-05 23.4 0.2 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch RabGAP-TBC PF00566.13 ESA11861.1 - 6.2e-21 74.8 0.6 1.2e-20 73.8 0.0 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain KaiB PF07689.7 ESA11862.1 - 0.0054 16.1 0.0 0.019 14.4 0.0 1.9 1 0 0 1 1 1 1 KaiB domain Abhydrolase_3 PF07859.8 ESA11864.1 - 0.068 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold SAM_2 PF07647.12 ESA11865.1 - 0.00016 21.4 0.1 0.00079 19.2 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA11865.1 - 0.0007 19.7 0.1 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Aa_trans PF01490.13 ESA11866.1 - 2.5e-09 36.1 36.0 1.7e-08 33.3 24.9 2.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein RNA_pol_Rpb4 PF03874.11 ESA11868.1 - 0.18 11.7 3.2 0.97 9.4 0.4 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb4 Abhydrolase_3 PF07859.8 ESA11869.1 - 2.3e-12 46.9 0.2 7e-05 22.5 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA11869.1 - 0.0024 16.5 0.1 0.042 12.4 0.0 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF2424) DUF659 PF04937.10 ESA11871.1 - 3e-05 23.5 0.2 0.00012 21.6 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Abhydrolase_3 PF07859.8 ESA11872.1 - 1.3e-05 24.8 0.0 9.2e-05 22.1 0.0 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold CRAL_TRIO PF00650.15 ESA11873.1 - 1.2e-06 28.1 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain R3H-assoc PF13902.1 ESA11875.1 - 0.084 12.8 0.5 1 9.2 0.1 2.2 1 1 1 2 2 2 0 R3H-associated N-terminal domain Arch_flagellin PF01917.11 ESA11875.1 - 0.091 12.3 0.4 0.11 12.0 0.3 1.2 1 0 0 1 1 1 0 Archaebacterial flagellin Abhydrolase_6 PF12697.2 ESA11876.1 - 1.3e-32 113.4 0.0 1.6e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA11876.1 - 5.8e-12 45.5 0.0 1.1e-11 44.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA11876.1 - 1.8e-11 44.0 0.1 5.9e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Ndr PF03096.9 ESA11876.1 - 1.5e-05 23.6 0.0 0.071 11.5 0.0 2.3 2 0 0 2 2 2 2 Ndr family DLH PF01738.13 ESA11876.1 - 0.0046 16.2 0.0 0.03 13.6 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.3 ESA11876.1 - 0.012 15.3 0.0 0.073 12.9 0.0 2.1 2 0 0 2 2 2 0 Putative lysophospholipase BAAT_C PF08840.6 ESA11876.1 - 0.017 14.8 0.0 0.36 10.4 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.8 ESA11876.1 - 0.022 14.3 0.1 0.071 12.6 0.0 1.9 2 1 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 ESA11876.1 - 0.063 12.4 0.0 0.47 9.6 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF2305 PF10230.4 ESA11876.1 - 0.082 12.3 0.0 0.18 11.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) Patatin PF01734.17 ESA11876.1 - 0.15 11.9 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Patatin-like phospholipase UPF0183 PF03676.9 ESA11877.1 - 9.5e-81 271.3 2.2 1.2e-78 264.4 1.1 2.2 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0183) Sel1 PF08238.7 ESA11878.1 - 1.9e-28 98.2 0.7 5.8e-12 45.8 0.0 3.3 3 0 0 3 3 3 3 Sel1 repeat TPR_2 PF07719.12 ESA11878.1 - 9.2 6.4 7.6 26 5.0 0.3 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF659 PF04937.10 ESA11879.1 - 2.8e-05 23.6 0.0 3.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Acid_PPase PF12689.2 ESA11879.1 - 0.075 12.6 0.1 0.1 12.1 0.0 1.3 1 1 0 1 1 1 0 Acid Phosphatase MIR PF02815.14 ESA11880.1 - 1.6e-06 27.8 0.1 0.019 14.5 0.0 2.4 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA11880.1 - 0.00017 20.6 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF1803 PF08820.5 ESA11880.1 - 0.023 14.3 1.0 4.4 7.0 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1803) CLAMP PF14769.1 ESA11880.1 - 0.027 14.6 0.1 0.33 11.1 0.0 2.3 2 0 0 2 2 2 0 Flagellar C1a complex subunit C1a-32 PAP_RNA-bind PF04926.10 ESA11880.1 - 0.033 13.6 0.1 0.092 12.2 0.0 1.8 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Sel1 PF08238.7 ESA11881.1 - 1.7e-135 438.4 62.9 1.6e-12 47.5 0.3 12.0 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA11881.1 - 8.4e-17 60.4 38.5 0.59 10.7 0.0 12.2 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_17 PF13431.1 ESA11881.1 - 4.4e-12 45.1 26.1 0.59 10.4 0.2 12.2 12 0 0 12 12 12 3 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA11881.1 - 7.3e-09 35.5 0.0 18 5.4 0.0 7.6 1 1 6 8 8 8 1 Influenza Matrix protein (M1) C-terminal domain MIT PF04212.13 ESA11881.1 - 5.9e-07 29.2 45.6 1.1 9.2 0.1 10.4 10 1 0 10 10 10 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA11881.1 - 0.00027 20.5 17.2 44 3.9 0.0 9.4 11 0 0 11 11 11 0 Lung surfactant protein D coiled-coil trimerisation IL22 PF14565.1 ESA11881.1 - 0.0081 16.2 3.5 4.1 7.4 0.0 4.5 3 1 2 5 5 5 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor zf-CCHC PF00098.18 ESA11882.1 - 3.4e-07 29.8 0.4 5.3e-07 29.2 0.3 1.3 1 0 0 1 1 1 1 Zinc knuckle gag-asp_proteas PF13975.1 ESA11882.1 - 0.00036 20.3 0.0 0.00087 19.0 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA11882.1 - 0.099 13.1 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Aspartyl protease VWA_2 PF13519.1 ESA11882.1 - 1.4 9.0 4.9 12 5.9 3.3 2.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Defensin_4 PF07936.7 ESA11883.1 - 1.1 8.9 9.4 4.2 7.1 2.2 2.7 1 1 1 2 2 2 0 Potassium-channel blocking toxin BTB PF00651.26 ESA11884.1 - 4.8e-07 29.7 0.8 7.7e-07 29.0 0.2 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA11884.1 - 5.9e-05 22.8 0.1 0.00015 21.5 0.1 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA11885.1 - 1.1e-13 51.3 2.8 3e-13 49.9 2.0 1.8 1 0 0 1 1 1 1 TLD ER-remodelling PF14755.1 ESA11885.1 - 0.96 9.5 4.1 1.5 8.8 2.8 1.2 1 0 0 1 1 1 0 Intracellular membrane remodeller Na_Ca_ex PF01699.19 ESA11886.1 - 2e-11 43.6 4.0 2e-11 43.6 2.7 2.2 2 0 0 2 2 2 1 Sodium/calcium exchanger protein hNIFK_binding PF12196.3 ESA11887.1 - 5.3e-05 22.5 6.3 0.0092 15.3 0.1 2.6 2 0 0 2 2 2 2 FHA Ki67 binding domain of hNIFK COP23 PF14218.1 ESA11888.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Rpr2 PF04032.11 ESA11889.1 - 0.2 11.5 1.2 0.37 10.6 0.5 1.6 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Pkinase PF00069.20 ESA11890.1 - 4.5e-40 137.4 0.1 5.7e-40 137.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11890.1 - 3.6e-39 134.3 0.0 4.5e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA11890.1 - 6.3e-06 25.3 0.0 1.2e-05 24.3 0.0 1.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA11890.1 - 0.0034 17.1 0.0 0.11 12.2 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA11890.1 - 0.0047 16.1 0.3 0.0076 15.4 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA11890.1 - 0.014 14.4 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA11890.1 - 0.046 13.0 0.1 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Sel1 PF08238.7 ESA11891.1 - 4.7e-147 475.2 91.8 2.7e-11 43.7 0.8 19.7 19 1 1 20 20 20 17 Sel1 repeat TPR_6 PF13174.1 ESA11891.1 - 3.4e-08 33.4 39.8 0.65 10.5 0.0 13.6 16 0 0 16 16 16 5 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA11891.1 - 0.01 15.8 1.2 13 5.8 0.0 5.1 5 0 0 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain Zn_clus PF00172.13 ESA11893.1 - 3.9e-09 36.2 12.6 5.7e-09 35.7 8.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_F17 PF04767.7 ESA11893.1 - 0.012 15.8 1.6 0.017 15.3 1.1 1.2 1 0 0 1 1 1 0 DNA-binding 11 kDa phosphoprotein TAXi_N PF14543.1 ESA11893.1 - 0.045 13.6 1.5 0.053 13.4 1.0 1.2 1 0 0 1 1 1 0 Xylanase inhibitor N-terminal Wzy_C PF04932.10 ESA11894.1 - 0.19 11.4 11.3 0.087 12.6 5.9 1.9 1 1 1 2 2 2 0 O-Antigen ligase Ninjurin PF04923.7 ESA11894.1 - 3.5 7.3 8.3 0.42 10.3 0.5 2.4 1 1 1 2 2 2 0 Ninjurin MACPF PF01823.14 ESA11896.1 - 3.4e-07 30.1 5.0 6.4e-07 29.2 3.5 1.4 1 0 0 1 1 1 1 MAC/Perforin domain Pkinase_Tyr PF07714.12 ESA11898.1 - 2.5e-14 52.9 0.1 3.9e-07 29.4 0.0 3.2 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA11898.1 - 1.2e-08 34.3 7.7 2.9e-08 33.2 2.1 3.4 2 1 0 2 2 2 1 Protein kinase domain BCS1_N PF08740.6 ESA11898.1 - 1.3e-07 31.4 0.0 0.001 18.6 0.0 2.3 2 0 0 2 2 2 2 BCS1 N terminal DUF4413 PF14372.1 ESA11898.1 - 0.0014 18.5 1.2 1.4 8.9 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4413) DUF4047 PF13256.1 ESA11898.1 - 0.0015 18.4 5.2 0.4 10.6 0.1 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF4047) INCENP_ARK-bind PF03941.10 ESA11898.1 - 0.0074 16.1 0.1 7.2 6.5 0.0 3.0 2 0 0 2 2 2 2 Inner centromere protein, ARK binding region phiKZ_IP PF12699.2 ESA11898.1 - 0.008 15.1 0.4 4 6.2 0.0 3.0 2 1 1 3 3 3 1 phiKZ-like phage internal head proteins SET_assoc PF11767.3 ESA11898.1 - 0.075 12.3 5.2 2.9 7.2 0.2 2.7 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated DnaJ_CXXCXGXG PF00684.14 ESA11898.1 - 0.61 10.1 9.8 3.9 7.5 1.0 2.3 2 0 0 2 2 2 0 DnaJ central domain Glyco_hydro_11 PF00457.12 ESA11898.1 - 2.4 7.4 13.6 20 4.4 0.5 4.9 3 3 2 5 5 5 0 Glycosyl hydrolases family 11 YARHG PF13308.1 ESA11900.1 - 0.074 12.6 0.2 0.14 11.7 0.1 1.5 1 1 1 2 2 2 0 YARHG domain zf-BED PF02892.10 ESA11901.1 - 5.6e-06 26.0 0.3 1.6e-05 24.5 0.2 1.8 1 1 0 1 1 1 1 BED zinc finger DUF581 PF04570.9 ESA11901.1 - 0.065 12.5 0.1 0.096 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF581) BTB PF00651.26 ESA11902.1 - 7.2e-16 58.1 0.0 1.5e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA11902.1 - 6.2e-10 39.1 3.5 6.2e-10 39.1 2.4 2.4 2 0 0 2 2 2 1 TLD RicinB_lectin_2 PF14200.1 ESA11902.1 - 1.1e-07 32.2 5.1 1.3e-05 25.5 0.4 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA11902.1 - 1.7e-07 31.2 0.9 7.3e-07 29.2 0.6 2.3 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain BACK PF07707.10 ESA11902.1 - 1.4e-06 28.1 2.8 3.9e-05 23.4 0.1 3.5 4 0 0 4 4 4 1 BTB And C-terminal Kelch bPH_1 PF08000.6 ESA11904.1 - 0.11 12.1 0.5 0.1 12.2 0.3 1.1 1 0 0 1 1 1 0 Bacterial PH domain Orthopox_B11R PF07033.6 ESA11905.1 - 0.042 13.3 4.1 0.23 10.9 1.6 2.1 2 0 0 2 2 2 0 Orthopoxvirus B11R protein DUF3637 PF12337.3 ESA11905.1 - 0.048 13.6 0.1 3.4 7.7 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3637) Cortex-I_coil PF09304.5 ESA11908.1 - 0.0038 17.2 12.8 0.0038 17.2 8.9 5.3 2 1 2 5 5 5 1 Cortexillin I, coiled coil Peptidase_S49_N PF08496.5 ESA11909.1 - 0.031 14.0 0.1 0.04 13.7 0.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PKD_channel PF08016.7 ESA11909.1 - 0.049 12.0 0.7 0.061 11.7 0.5 1.1 1 0 0 1 1 1 0 Polycystin cation channel ETC_C1_NDUFA5 PF04716.9 ESA11910.1 - 3.2e-23 80.9 1.4 3.2e-23 80.9 1.0 1.7 2 0 0 2 2 2 1 ETC complex I subunit conserved region HMG_CoA_synt_C PF08540.5 ESA11911.1 - 5.5e-105 350.8 3.1 7.1e-105 350.5 2.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 ESA11911.1 - 1.8e-97 323.9 0.4 2.5e-97 323.4 0.3 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III PF08545.5 ESA11911.1 - 0.092 12.4 0.1 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF1925 PF09094.6 ESA11913.1 - 8.2e-06 25.7 1.4 0.11 12.5 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1925) NOB1_Zn_bind PF08772.6 ESA11913.1 - 0.0073 16.1 4.1 0.096 12.5 0.1 2.7 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like KTI12 PF08433.5 ESA11913.1 - 0.011 15.0 0.6 0.011 15.0 0.4 1.9 2 1 0 2 2 2 0 Chromatin associated protein KTI12 DZR PF12773.2 ESA11913.1 - 0.024 14.4 5.9 1.7 8.5 0.6 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESA11913.1 - 0.36 10.0 2.2 7.2 5.9 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain CM2 PF03021.9 ESA11913.1 - 1.2 8.6 5.8 12 5.4 0.9 2.7 2 1 0 2 2 2 0 Influenza C virus M2 protein Thioredoxin_7 PF13899.1 ESA11913.1 - 2.2 8.3 6.2 2.2 8.3 0.0 3.2 2 1 1 3 3 3 0 Thioredoxin-like DUF4413 PF14372.1 ESA11913.1 - 2.9 7.9 9.1 11 6.1 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) Hemerythrin PF01814.18 ESA11916.1 - 0.03 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain NUMOD4 PF07463.6 ESA11917.1 - 0.11 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 NUMOD4 motif zf-Nse PF11789.3 ESA11918.1 - 2.5e-18 65.3 0.6 3.7e-18 64.7 0.4 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESA11918.1 - 0.00026 20.6 0.5 0.00061 19.4 0.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.15 ESA11918.1 - 0.0007 19.0 0.3 0.0011 18.4 0.2 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.20 ESA11918.1 - 0.0021 17.6 0.1 0.0052 16.4 0.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 ESA11918.1 - 0.0023 17.2 6.2 0.017 14.3 0.0 2.0 1 1 1 2 2 2 1 Rtf2 RING-finger zf-RING_2 PF13639.1 ESA11918.1 - 0.0031 17.3 0.3 0.0049 16.6 0.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-Apc11 PF12861.2 ESA11918.1 - 0.015 15.1 0.2 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 ESA11918.1 - 0.051 13.6 0.3 0.12 12.4 0.2 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA11918.1 - 0.061 13.2 1.0 0.1 12.5 0.7 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 ESA11918.1 - 0.12 12.5 0.1 0.22 11.6 0.0 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger zf-CCHC_6 PF15288.1 ESA11918.1 - 0.32 10.6 1.6 0.5 10.0 0.0 2.1 2 1 0 2 2 2 0 Zinc knuckle dsrm PF00035.20 ESA11919.1 - 1.7e-09 38.1 4.0 5e-07 30.2 0.1 2.7 3 0 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.1 ESA11919.1 - 5.6e-06 26.5 1.1 0.14 12.4 0.1 2.9 2 1 0 2 2 2 2 double strand RNA binding domain from DEAD END PROTEIN 1 Glutaredoxin PF00462.19 ESA11920.1 - 8.7e-36 121.7 0.1 6.4e-17 61.2 0.0 3.2 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.15 ESA11920.1 - 9.1e-17 60.6 0.0 3.8e-16 58.6 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 ESA11920.1 - 8.2e-06 25.9 0.1 0.0054 16.9 0.0 3.9 3 2 0 3 3 3 1 Thioredoxin-like domain SH3BGR PF04908.10 ESA11920.1 - 1.5e-05 24.8 0.0 0.0084 16.0 0.0 2.6 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein ArsC PF03960.10 ESA11920.1 - 2.5e-05 24.3 0.0 0.33 11.0 0.0 3.3 3 0 0 3 3 3 2 ArsC family Thioredoxin_8 PF13905.1 ESA11920.1 - 2.9e-05 24.0 0.7 0.0023 18.0 0.0 3.2 3 1 1 4 4 4 1 Thioredoxin-like Phosducin PF02114.11 ESA11920.1 - 0.00012 20.9 0.0 0.00025 19.8 0.0 1.5 1 0 0 1 1 1 1 Phosducin Thioredoxin_3 PF13192.1 ESA11920.1 - 0.0004 20.1 0.1 0.035 13.9 0.0 3.5 4 0 0 4 4 4 1 Thioredoxin domain GST_N_3 PF13417.1 ESA11920.1 - 0.0052 16.9 0.0 1.4 9.1 0.0 2.7 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain AhpC-TSA PF00578.16 ESA11920.1 - 0.0058 16.3 0.1 0.041 13.5 0.0 2.4 3 1 0 3 3 3 1 AhpC/TSA family HyaE PF07449.6 ESA11920.1 - 0.0085 15.9 0.1 1.1 9.2 0.0 3.5 2 2 1 3 3 3 1 Hydrogenase-1 expression protein HyaE DIM1 PF02966.11 ESA11920.1 - 0.0097 15.4 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Mitosis protein DIM1 TrbC_Ftype PF09673.5 ESA11920.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.7 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin assembly protein Redoxin PF08534.5 ESA11920.1 - 0.034 13.7 0.2 1.9 8.0 0.0 3.0 3 1 1 4 4 4 0 Redoxin YodA PF09223.6 ESA11920.1 - 0.13 11.8 0.0 3.5 7.2 0.0 2.2 2 0 0 2 2 2 0 YodA lipocalin-like domain FlgI PF02119.11 ESA11921.1 - 0.053 12.1 0.3 0.094 11.3 0.2 1.4 1 1 0 1 1 1 0 Flagellar P-ring protein TPR_21 PF09976.4 ESA11921.1 - 0.17 11.8 5.3 0.22 11.4 0.3 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF4548 PF15081.1 ESA11922.1 - 0.038 13.5 0.1 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) PTPS PF01242.14 ESA11922.1 - 0.042 13.5 0.0 0.38 10.4 0.0 1.9 1 1 1 2 2 2 0 6-pyruvoyl tetrahydropterin synthase YokU PF14122.1 ESA11922.1 - 0.055 13.2 0.1 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 YokU-like protein IBB PF01749.15 ESA11925.1 - 0.14 12.2 3.3 0.15 12.2 2.3 1.1 1 0 0 1 1 1 0 Importin beta binding domain VIT PF08487.5 ESA11925.1 - 0.22 11.2 3.5 0.27 10.9 2.4 1.1 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain FAR1 PF03101.10 ESA11926.1 - 3.1e-08 34.0 1.4 5.8e-08 33.1 1.0 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA11926.1 - 0.00017 21.1 1.9 0.0027 17.2 0.0 2.3 2 0 0 2 2 2 1 MuDR family transposase DUF4609 PF15382.1 ESA11926.1 - 0.015 15.0 0.2 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) ALS2CR8 PF15299.1 ESA11926.1 - 0.85 9.1 5.0 5.8 6.4 1.0 2.4 2 1 1 3 3 3 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 MULE PF10551.4 ESA11927.1 - 1.1e-10 41.5 0.0 2.6e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain FAR1 PF03101.10 ESA11927.1 - 0.018 15.5 1.4 0.04 14.4 0.9 1.6 1 0 0 1 1 1 0 FAR1 DNA-binding domain Snapin_Pallidin PF14712.1 ESA11927.1 - 0.02 15.1 4.2 0.1 12.9 1.5 2.5 2 0 0 2 2 2 0 Snapin/Pallidin PMP22_Claudin PF00822.15 ESA11928.1 - 0.088 12.4 0.6 0.14 11.8 0.4 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Atrophin-1 PF03154.10 ESA11928.1 - 0.42 8.6 9.0 0.58 8.2 6.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family Transformer PF06495.6 ESA11928.1 - 4.3 7.1 9.8 8 6.2 6.8 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein Cytochrome_cB PF11783.3 ESA11930.1 - 0.11 11.9 0.0 0.12 11.9 0.0 1.0 1 0 0 1 1 1 0 Cytochrome c bacterial DUF4403 PF14356.1 ESA11931.1 - 0.064 11.5 0.4 0.058 11.6 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) Levi_coat PF01819.12 ESA11931.1 - 0.083 12.4 0.1 0.093 12.3 0.1 1.1 1 0 0 1 1 1 0 Levivirus coat protein Flocculin PF00624.13 ESA11931.1 - 7 6.5 12.8 9.6 6.1 8.9 1.2 1 0 0 1 1 1 0 Flocculin repeat Pkinase PF00069.20 ESA11932.1 - 0.063 12.4 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11932.1 - 0.069 12.2 0.0 0.082 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase TcdB_toxin_midN PF12256.3 ESA11932.1 - 0.083 12.3 0.0 0.083 12.3 0.0 1.1 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region DUF1570 PF07607.6 ESA11932.1 - 0.12 12.3 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) ABC_tran_2 PF12848.2 ESA11934.1 - 0.98 9.3 8.3 0.25 11.1 3.0 1.9 2 0 0 2 2 2 0 ABC transporter HMG_box PF00505.14 ESA11935.1 - 2.3e-06 27.7 0.2 5.5e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA11935.1 - 5.6e-05 23.4 0.3 9.9e-05 22.6 0.2 1.4 1 0 0 1 1 1 1 HMG-box domain MAT_Alpha1 PF04769.7 ESA11935.1 - 0.16 11.3 2.2 0.12 11.6 0.5 1.6 1 1 1 2 2 2 0 Mating-type protein MAT alpha 1 DUF2985 PF11204.3 ESA11936.1 - 0.0088 15.7 6.5 0.14 11.9 1.5 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF2985) Pkinase_Tyr PF07714.12 ESA11938.1 - 1.3e-05 24.4 0.0 2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase GP41 PF00517.12 ESA11938.1 - 0.0035 16.9 0.9 0.004 16.7 0.6 1.1 1 0 0 1 1 1 1 Retroviral envelope protein Pkinase PF00069.20 ESA11938.1 - 0.033 13.3 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Cu-binding_MopE PF11617.3 ESA11938.1 - 0.037 13.8 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein metal binding site F-box-like PF12937.2 ESA11939.1 - 7.3e-06 25.6 0.7 2e-05 24.2 0.5 1.8 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA11939.1 - 6.3 6.6 14.0 2.6 7.8 0.7 4.5 4 2 0 4 4 4 0 Leucine rich repeat BTB_2 PF02214.17 ESA11940.1 - 9.4e-18 64.2 4.8 1.2e-17 63.9 0.1 3.1 4 0 0 4 4 4 1 BTB/POZ domain Glyco_transf_11 PF01531.11 ESA11940.1 - 0.086 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 11 Sel1 PF08238.7 ESA11941.1 - 4.5e-37 125.6 15.3 6.8e-08 32.9 0.0 5.7 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA11941.1 - 0.028 14.8 5.4 26 5.5 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat MMtag PF10159.4 ESA11941.1 - 6.6 6.8 8.6 1.2 9.1 0.8 2.9 2 1 1 3 3 3 0 Kinase phosphorylation protein DUF3841 PF12952.2 ESA11942.1 - 0.05 13.0 0.0 0.057 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3841) BTB PF00651.26 ESA11943.1 - 2.4e-18 66.1 0.1 3e-18 65.8 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA11943.1 - 0.11 12.6 0.2 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Plasmodium_Vir PF05795.6 ESA11945.1 - 4.8 6.2 8.4 0.077 12.1 0.7 1.7 2 0 0 2 2 2 0 Plasmodium vivax Vir protein SEN1_N PF12726.2 ESA11946.1 - 0.00047 18.3 0.1 0.0097 14.0 0.0 2.2 1 1 1 2 2 2 1 SEN1 N terminal HEAT_2 PF13646.1 ESA11946.1 - 0.002 18.3 0.5 0.76 10.1 0.0 3.7 2 2 1 4 4 4 1 HEAT repeats HEAT_EZ PF13513.1 ESA11946.1 - 0.0049 17.3 0.1 2.2 8.8 0.0 3.3 3 1 0 3 3 3 1 HEAT-like repeat HEAT PF02985.17 ESA11946.1 - 0.041 13.9 5.6 8.6 6.7 0.0 4.3 5 0 0 5 5 5 0 HEAT repeat Laminin_G_3 PF13385.1 ESA11951.1 - 5.4e-05 23.4 0.1 5.9e-05 23.3 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Toxin_R_bind_N PF07953.7 ESA11951.1 - 0.0049 16.3 0.4 0.0062 16.0 0.3 1.2 1 0 0 1 1 1 1 Clostridium neurotoxin, N-terminal receptor binding DUF565 PF04483.7 ESA11953.1 - 0.016 15.3 1.0 0.021 14.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF565) DDE_3 PF13358.1 ESA11955.1 - 5.4e-05 22.9 0.0 0.00013 21.6 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Adeno_E4_34 PF04528.8 ESA11955.1 - 0.05 13.1 0.2 0.088 12.3 0.2 1.3 1 0 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region DUF3908 PF13048.1 ESA11956.1 - 0.018 14.9 0.2 0.04 13.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3908) CBM_5_12_2 PF14600.1 ESA11957.1 - 0.06 12.9 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 0 Cellulose-binding domain rve PF00665.21 ESA11958.1 - 1.1e-05 25.5 0.1 0.068 13.2 0.0 2.2 1 1 1 2 2 2 2 Integrase core domain DnaB_2 PF07261.6 ESA11959.1 - 0.0062 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Replication initiation and membrane attachment LIN37 PF15306.1 ESA11959.1 - 0.013 15.4 0.9 0.02 14.8 0.6 1.3 1 1 0 1 1 1 0 LIN37 DUF4468 PF14730.1 ESA11959.1 - 0.19 11.4 3.0 0.18 11.5 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold RNase_H PF00075.19 ESA11961.1 - 1.2e-12 48.2 0.0 4.5e-12 46.4 0.0 1.8 2 0 0 2 2 2 1 RNase H CDC14 PF08045.6 ESA11961.1 - 0.0046 16.1 1.5 0.06 12.4 0.0 2.4 2 1 0 2 2 2 1 Cell division control protein 14, SIN component Rubredoxin PF00301.15 ESA11961.1 - 0.032 14.1 1.7 0.055 13.3 0.0 2.2 2 1 0 2 2 2 0 Rubredoxin ABC_tran PF00005.22 ESA11965.1 - 4.7e-30 104.6 0.0 7.2e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA11965.1 - 3.6e-07 30.4 0.0 0.015 15.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 ESA11965.1 - 4.1e-05 22.8 0.6 0.0035 16.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 ESA11965.1 - 0.00056 19.1 0.1 0.00079 18.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA11965.1 - 0.0012 18.3 0.5 0.33 10.3 0.1 2.1 2 0 0 2 2 2 2 AAA-like domain SbcCD_C PF13558.1 ESA11965.1 - 0.0024 17.7 0.0 0.053 13.4 0.0 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 ESA11965.1 - 0.0026 17.9 0.2 0.061 13.4 0.1 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 ESA11965.1 - 0.0026 16.6 0.6 0.0052 15.6 0.4 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.1 ESA11965.1 - 0.0026 17.1 0.4 0.0087 15.4 0.3 1.9 1 1 0 1 1 1 1 AAA domain UPF0079 PF02367.12 ESA11965.1 - 0.0035 16.9 0.5 0.015 14.9 0.1 2.0 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 ESA11965.1 - 0.0036 16.9 0.5 0.0086 15.7 0.1 1.8 2 0 0 2 2 2 1 NACHT domain ABC_ATPase PF09818.4 ESA11965.1 - 0.0062 15.1 0.9 0.82 8.1 0.2 2.7 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA PF00004.24 ESA11965.1 - 0.0069 16.5 0.2 0.031 14.4 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 ESA11965.1 - 0.011 15.4 0.2 0.029 14.0 0.1 1.8 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 ESA11965.1 - 0.012 15.6 0.2 0.027 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.18 ESA11965.1 - 0.014 15.3 0.5 0.071 13.0 0.4 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.1 ESA11965.1 - 0.017 14.1 0.1 0.046 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 ESA11965.1 - 0.019 14.4 0.1 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 ESA11965.1 - 0.028 14.9 0.0 0.079 13.4 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein SMC_N PF02463.14 ESA11965.1 - 0.03 13.5 0.2 0.38 9.9 0.1 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 ESA11965.1 - 0.056 13.7 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESA11965.1 - 0.061 13.2 0.1 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3638 PF12340.3 ESA11965.1 - 0.062 12.2 0.1 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_30 PF13604.1 ESA11965.1 - 0.071 12.6 0.2 0.21 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 ESA11965.1 - 0.12 11.8 0.3 0.19 11.2 0.2 1.6 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain CN_hydrolase PF00795.17 ESA11966.1 - 0.00032 20.0 0.0 0.00036 19.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF2339 PF10101.4 ESA11967.1 - 0.0038 15.5 2.7 0.0047 15.2 1.9 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) DUF1212 PF06738.7 ESA11967.1 - 0.024 14.1 1.3 0.55 9.6 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1212) DUF485 PF04341.7 ESA11967.1 - 0.15 11.7 2.0 0.32 10.7 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF485 YfhO PF09586.5 ESA11967.1 - 0.16 9.9 4.0 0.18 9.7 2.8 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF805 PF05656.9 ESA11967.1 - 0.26 11.1 2.5 0.42 10.4 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF805) Orbi_NS3 PF01616.11 ESA11967.1 - 0.27 10.1 2.7 6.4 5.6 0.0 2.1 1 1 1 2 2 2 0 Orbivirus NS3 DUF3981 PF13139.1 ESA11967.1 - 0.3 11.0 4.3 0.28 11.1 2.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3981) SID-1_RNA_chan PF13965.1 ESA11967.1 - 0.42 8.7 4.8 0.49 8.5 3.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1673 PF07895.6 ESA11967.1 - 1.6 8.2 8.3 3.4 7.1 5.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) Na_Ca_ex PF01699.19 ESA11967.1 - 1.7 8.2 6.4 0.28 10.7 1.4 1.8 1 1 1 2 2 2 0 Sodium/calcium exchanger protein Wzy_C PF04932.10 ESA11967.1 - 4.9 6.9 7.1 9.6 5.9 4.9 1.6 1 1 0 1 1 1 0 O-Antigen ligase Peptidase_M18 PF02127.10 ESA11968.1 - 5.2e-170 565.6 0.0 6e-170 565.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 ESA11968.1 - 1e-07 31.0 0.2 7.1e-07 28.2 0.1 2.0 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Tricho_coat PF05892.6 ESA11968.1 - 0.083 12.0 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Trichovirus coat protein Na_Ca_ex PF01699.19 ESA11969.1 - 1e-31 109.3 33.6 1.3e-18 66.9 9.0 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein DUF2636 PF11120.3 ESA11969.1 - 0.15 11.6 0.4 0.39 10.2 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2636) BLOC1_2 PF10046.4 ESA11971.1 - 0.02 15.0 0.2 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RE_AlwI PF09491.5 ESA11971.1 - 0.026 13.0 0.5 0.034 12.6 0.3 1.2 1 0 0 1 1 1 0 AlwI restriction endonuclease LRS4 PF10422.4 ESA11971.1 - 0.043 13.1 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Polysacc_deac_2 PF04748.8 ESA11971.1 - 0.057 12.4 0.0 0.096 11.6 0.0 1.3 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Pkinase PF00069.20 ESA11972.1 - 5e-45 153.6 0.2 7.9e-45 153.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11972.1 - 1.7e-44 151.8 0.0 2.6e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA11972.1 - 0.085 12.5 0.1 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF755 PF05501.6 ESA11973.1 - 0.1 12.6 12.0 0.23 11.5 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Dynamin_M PF01031.15 ESA11974.1 - 0.0072 15.1 4.8 0.013 14.3 3.2 1.3 1 1 0 1 1 1 1 Dynamin central region U5_2-snRNA_bdg PF10597.4 ESA11974.1 - 0.06 12.9 0.1 0.18 11.4 0.0 1.8 1 1 0 1 1 1 0 U5-snRNA binding site 2 of PrP8 DUF4559 PF15112.1 ESA11974.1 - 0.097 11.8 6.4 0.14 11.3 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) GLE1 PF07817.8 ESA11974.1 - 0.1 11.5 2.0 0.19 10.6 1.4 1.4 1 0 0 1 1 1 0 GLE1-like protein Sec20 PF03908.8 ESA11974.1 - 0.18 11.4 2.4 0.18 11.5 0.6 1.8 2 0 0 2 2 2 0 Sec20 Allexi_40kDa PF05549.6 ESA11974.1 - 1.4 8.1 7.0 0.64 9.2 1.7 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein Myb_Cef PF11831.3 ESA11975.1 - 3e-45 154.2 10.7 3e-45 154.2 7.4 3.1 2 0 0 2 2 2 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.26 ESA11975.1 - 6.7e-22 77.2 4.4 3.4e-11 43.0 0.3 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA11975.1 - 1.4e-21 76.3 8.1 2.7e-14 52.9 2.7 3.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain Band_7_1 PF13421.1 ESA11975.1 - 0.13 11.7 2.8 0.3 10.5 1.2 1.9 1 1 1 2 2 2 0 SPFH domain-Band 7 family Reo_sigmaC PF04582.7 ESA11975.1 - 0.47 9.5 3.8 0.73 8.9 2.6 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein PARP PF00644.15 ESA11976.1 - 3.8e-14 52.6 0.2 3.7e-13 49.3 0.1 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain zf-RING_2 PF13639.1 ESA11976.1 - 5.7e-09 35.6 5.7 1.3e-08 34.5 3.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA11976.1 - 8.2e-07 29.0 3.1 1.9e-06 27.9 2.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESA11976.1 - 6.1e-05 22.7 4.4 0.00018 21.2 3.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ESA11976.1 - 0.00047 19.8 4.8 0.0011 18.6 3.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA11976.1 - 0.00078 19.0 6.7 0.0017 17.9 4.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 ESA11976.1 - 0.011 15.4 3.3 0.025 14.2 2.3 1.7 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 ESA11976.1 - 0.015 15.0 5.9 0.039 13.6 0.3 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-Nse PF11789.3 ESA11976.1 - 0.025 14.1 3.7 0.067 12.7 2.6 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.2 ESA11976.1 - 0.032 14.2 3.4 0.071 13.1 2.3 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 ESA11976.1 - 0.1 12.5 7.5 0.39 10.7 5.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.1 ESA11976.1 - 0.15 11.7 8.2 0.34 10.6 5.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PTS_2-RNA PF01885.11 ESA11976.1 - 0.16 11.2 0.0 0.46 9.7 0.0 1.8 2 0 0 2 2 2 0 RNA 2'-phosphotransferase, Tpt1 / KptA family zf-C3HC4_2 PF13923.1 ESA11976.1 - 0.17 11.9 11.3 0.022 14.7 4.7 2.0 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA11976.1 - 0.31 10.9 5.2 1.1 9.2 3.6 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA11976.1 - 1.9 8.2 8.0 4.5 7.0 5.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger ubiquitin PF00240.18 ESA11977.1 - 1.1e-16 59.9 3.0 1.9e-16 59.1 2.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 ESA11977.1 - 4.7e-11 42.1 0.3 8.8e-11 41.3 0.2 1.5 1 0 0 1 1 1 1 UBA/TS-N domain DUF2407 PF10302.4 ESA11977.1 - 1.6e-05 24.9 0.9 2.6e-05 24.3 0.5 1.4 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.3 ESA11977.1 - 3.9e-05 23.2 2.0 5.7e-05 22.7 1.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF1421 PF07223.6 ESA11977.1 - 0.0037 17.0 2.6 0.0037 17.0 1.8 1.5 1 1 0 2 2 2 1 Protein of unknown function (DUF1421) Rad60-SLD_2 PF13881.1 ESA11977.1 - 0.0042 16.9 0.8 0.013 15.3 0.1 2.1 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA11977.1 - 0.11 12.7 0.8 0.35 11.1 0.6 1.9 1 1 0 1 1 1 0 Ubiquitin-like domain CUE PF02845.11 ESA11977.1 - 0.12 11.8 0.0 2.6 7.6 0.0 2.4 1 1 1 2 2 2 0 CUE domain UBA_2 PF08587.6 ESA11977.1 - 0.21 11.8 0.9 0.47 10.6 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Atg8 PF02991.11 ESA11978.1 - 0.02 14.8 0.1 0.057 13.3 0.1 1.8 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like AAA_16 PF13191.1 ESA11978.1 - 0.073 13.0 0.0 0.35 10.8 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain Mito_carr PF00153.22 ESA11980.1 - 1e-28 98.8 0.8 1.1e-14 53.9 0.0 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein Mito_fiss_Elm1 PF06258.6 ESA11980.1 - 0.049 12.5 0.0 0.065 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission ELM1 Pkinase_Tyr PF07714.12 ESA11981.1 - 5.2e-26 91.2 0.2 7.7e-26 90.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11981.1 - 5e-25 88.1 0.2 7.6e-25 87.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA11981.1 - 1.2e-07 32.1 4.8 8.7e-07 29.3 0.1 3.6 4 0 0 4 4 4 1 Sel1 repeat Kinase-like PF14531.1 ESA11981.1 - 0.025 13.5 0.0 0.038 12.9 0.0 1.1 1 0 0 1 1 1 0 Kinase-like TPR_2 PF07719.12 ESA11981.1 - 0.5 10.4 3.1 75 3.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat NUC173 PF08161.7 ESA11983.1 - 0.016 14.5 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 NUC173 domain NHS PF15273.1 ESA11983.1 - 0.034 12.8 2.8 0.046 12.3 2.0 1.1 1 0 0 1 1 1 0 NHS-like DUF1068 PF06364.7 ESA11983.1 - 0.097 12.2 0.7 0.18 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Imm32 PF15579.1 ESA11983.1 - 0.12 11.9 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 32 Dimer_Tnp_hAT PF05699.9 ESA11984.1 - 1.1e-09 37.8 0.3 1.4e-08 34.2 0.1 2.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA11984.1 - 6.3e-06 26.1 1.4 1.1e-05 25.3 0.2 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4413) DUF745 PF05335.8 ESA11985.1 - 0.0039 16.7 22.1 0.0076 15.7 8.4 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF745) DUF4226 PF10774.4 ESA11985.1 - 0.006 16.6 4.2 2.5 8.1 0.1 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4226) DUF869 PF05911.6 ESA11985.1 - 0.011 13.9 27.2 0.015 13.5 18.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF1395 PF07160.7 ESA11985.1 - 0.013 15.0 24.3 0.12 11.8 4.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1395) TMF_TATA_bd PF12325.3 ESA11985.1 - 0.03 14.0 38.0 0.18 11.5 8.1 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.1 ESA11985.1 - 0.041 13.8 3.7 0.041 13.8 2.6 4.5 1 1 3 4 4 4 0 Centrosome localisation domain of PPC89 WEMBL PF05701.6 ESA11985.1 - 0.13 10.6 33.0 0.19 10.1 22.9 1.3 1 0 0 1 1 1 0 Weak chloroplast movement under blue light IMD PF08397.6 ESA11985.1 - 0.22 10.7 31.4 0.29 10.4 2.8 2.7 1 1 2 3 3 3 0 IRSp53/MIM homology domain DUF4047 PF13256.1 ESA11985.1 - 0.35 10.8 25.1 1.8 8.5 2.8 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4047) OmpH PF03938.9 ESA11985.1 - 0.5 10.3 33.9 2.8 7.8 13.4 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Tuberin PF03542.11 ESA11985.1 - 0.55 9.2 7.0 0.85 8.6 4.8 1.4 1 1 0 1 1 1 0 Tuberin DUF4633 PF15464.1 ESA11985.1 - 0.57 10.0 3.3 4.3 7.2 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4633) PRKCSH-like PF12999.2 ESA11985.1 - 1 8.9 29.3 2.2 7.8 2.9 3.1 1 1 2 3 3 3 0 Glucosidase II beta subunit-like Tox-REase-2 PF15646.1 ESA11985.1 - 1.1 9.1 15.8 0.073 12.9 2.2 3.0 1 1 2 3 3 3 0 Restriction endonuclease fold toxin 2 AAA_13 PF13166.1 ESA11985.1 - 1.2 7.5 42.8 2.9 6.2 29.7 1.5 1 1 0 1 1 1 0 AAA domain Effector_1 PF04518.7 ESA11985.1 - 1.2 8.0 28.3 1.5 7.7 2.4 2.9 1 1 2 3 3 3 0 Effector from type III secretion system DUF2385 PF09539.5 ESA11985.1 - 1.3 9.4 4.4 20 5.6 0.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2385) Bestrophin PF01062.16 ESA11985.1 - 1.3 7.9 10.3 0.17 10.7 3.3 2.0 1 1 1 2 2 2 0 Bestrophin, RFP-TM, chloride channel DUF342 PF03961.8 ESA11985.1 - 1.6 7.0 41.4 0.34 9.2 13.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF342) SLT_2 PF13406.1 ESA11985.1 - 1.9 7.3 8.8 0.15 10.9 0.7 2.3 1 1 2 3 3 3 0 Transglycosylase SLT domain IncA PF04156.9 ESA11985.1 - 2 7.9 42.3 5.3 6.5 6.1 2.4 1 1 1 2 2 2 0 IncA protein CCDC155 PF14662.1 ESA11985.1 - 2.2 7.8 37.3 4.2 6.9 25.8 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 DUF1322 PF07032.6 ESA11985.1 - 2.8 8.1 14.4 1.5 9.0 1.3 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF1322) FliD_C PF07195.7 ESA11985.1 - 2.9 7.0 28.9 2.7 7.2 5.9 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus ADIP PF11559.3 ESA11985.1 - 4.7 7.1 39.9 3.6 7.4 11.6 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 ESA11985.1 - 7.7 5.5 7.6 2.8 7.0 1.8 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein APG6 PF04111.7 ESA11985.1 - 8.9 5.2 40.5 0.56 9.2 17.1 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 Snapin_Pallidin PF14712.1 ESA11985.1 - 9.2 6.6 33.0 1.6 9.1 7.2 3.5 1 1 2 3 3 3 0 Snapin/Pallidin Kelch_5 PF13854.1 ESA11986.1 - 3.5e-15 55.5 0.1 0.001 18.9 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.10 ESA11986.1 - 9.3e-12 44.2 0.0 0.051 13.3 0.1 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 ESA11986.1 - 1.6e-11 43.7 10.0 0.029 14.1 1.5 5.3 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA11986.1 - 7.7e-08 32.1 9.2 0.082 13.1 0.8 4.6 3 2 1 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA11986.1 - 8.7e-06 25.1 5.0 0.016 14.7 0.0 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA11986.1 - 1.8e-05 24.7 4.6 0.039 14.1 0.2 4.4 4 1 0 4 4 4 2 Galactose oxidase, central domain RAG2 PF03089.9 ESA11986.1 - 0.06 12.0 0.0 0.093 11.4 0.0 1.3 1 0 0 1 1 1 0 Recombination activating protein 2 Bunya_G1 PF03557.10 ESA11987.1 - 0.0015 16.4 1.0 0.0018 16.2 0.7 1.0 1 0 0 1 1 1 1 Bunyavirus glycoprotein G1 p450 PF00067.17 ESA11989.1 - 3.3e-52 177.5 0.0 3.9e-52 177.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_Tyr PF07714.12 ESA11990.1 - 4.4e-63 212.7 0.3 3.5e-40 137.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA11990.1 - 8.5e-55 185.7 2.7 1.2e-34 119.6 0.3 2.2 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.9 ESA11990.1 - 7.3e-05 21.9 0.6 0.00022 20.3 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA11990.1 - 0.00072 18.5 0.0 0.0025 16.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA11990.1 - 0.0051 16.1 0.3 0.077 12.3 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA11990.1 - 0.0075 15.6 1.0 0.019 14.3 0.2 2.0 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA11990.1 - 0.017 14.8 0.7 0.034 13.8 0.2 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF4474 PF14751.1 ESA11991.1 - 0.012 14.7 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) LSPR PF06049.7 ESA11992.1 - 0.13 11.7 0.4 1.3 8.7 0.0 2.6 3 0 0 3 3 3 0 Coagulation Factor V LSPD Repeat Pkinase PF00069.20 ESA11993.1 - 6.3e-15 55.0 0.1 8.3e-15 54.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA11993.1 - 4.7e-14 52.0 0.0 6.4e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3865 PF12981.2 ESA11993.1 - 0.00029 20.6 0.1 0.00033 20.5 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function with PDB structure (DUF3865) FTA2 PF13095.1 ESA11993.1 - 0.063 12.8 0.3 0.068 12.7 0.2 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_Tyr PF07714.12 ESA11994.1 - 1.3e-06 27.6 0.0 1.6e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA11994.1 - 0.0048 16.0 0.0 0.0065 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ldh_1_C PF02866.13 ESA11996.1 - 7.8e-44 149.4 0.0 1.1e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 ESA11996.1 - 1.1e-07 31.8 0.3 1.8e-07 31.0 0.2 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain EamA PF00892.15 ESA11998.1 - 0.011 15.7 1.7 0.011 15.7 1.2 1.7 1 1 1 2 2 2 0 EamA-like transporter family Chordopox_A13L PF05961.6 ESA11998.1 - 0.08 12.8 1.4 0.2 11.6 1.0 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF3671 PF12420.3 ESA11998.1 - 0.21 11.5 12.4 1.5 8.8 8.6 2.0 1 1 0 1 1 1 0 Protein of unknown function RHD3 PF05879.7 ESA12000.1 - 2.3e-10 39.0 0.0 5e-10 37.9 0.0 1.6 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 ESA12000.1 - 3.9e-07 29.3 0.2 5.9e-07 28.8 0.1 1.4 1 1 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.18 ESA12000.1 - 0.00034 20.5 0.1 0.0007 19.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA12000.1 - 0.0071 16.1 0.3 0.018 14.8 0.1 1.7 1 1 0 1 1 1 1 Dynamin family Miro PF08477.8 ESA12000.1 - 0.025 15.0 0.0 0.043 14.3 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein Gtr1_RagA PF04670.7 ESA12000.1 - 0.03 13.4 0.1 0.043 12.9 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region IIGP PF05049.8 ESA12000.1 - 0.077 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Med2 PF11214.3 ESA12000.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 Serpentine_r_xa PF03383.10 ESA12000.1 - 0.096 12.4 0.2 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa Ras PF00071.17 ESA12000.1 - 0.1 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Ras family Ni_hydr_CYTB PF01292.15 ESA12002.1 - 0.056 12.8 0.5 0.075 12.4 0.3 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Cep57_MT_bd PF06657.8 ESA12003.1 - 5.2e-15 55.1 2.0 1.1e-14 54.0 1.4 1.6 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 HTH_37 PF13744.1 ESA12003.1 - 0.0088 15.8 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Abhydrolase_5 PF12695.2 ESA12004.1 - 1.2e-20 73.7 0.0 1.6e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA12004.1 - 1.2e-15 58.0 0.0 5.5e-10 39.5 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA12004.1 - 9.4e-07 28.6 0.0 0.0075 15.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.7 ESA12004.1 - 4.9e-06 25.2 0.1 0.21 10.0 0.0 3.0 2 1 1 3 3 3 3 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.13 ESA12004.1 - 2.6e-05 23.8 0.0 0.061 12.7 0.0 2.1 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.11 ESA12004.1 - 5.6e-05 22.6 0.0 0.034 13.5 0.0 2.1 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 ESA12004.1 - 0.00015 21.0 0.0 0.0014 17.8 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.8 ESA12004.1 - 0.0077 15.6 0.0 0.0098 15.3 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF818 PF05677.7 ESA12004.1 - 0.016 13.9 0.0 0.019 13.6 0.0 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Hydrolase_4 PF12146.3 ESA12004.1 - 0.034 13.9 0.0 0.085 12.7 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase DLH PF01738.13 ESA12004.1 - 0.13 11.5 0.0 1.8 7.8 0.0 2.5 2 1 0 2 2 2 0 Dienelactone hydrolase family TMA7 PF09072.5 ESA12005.1 - 2.6e-23 82.2 18.8 3.2e-23 81.9 13.0 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 rRNA_processing PF08524.6 ESA12005.1 - 0.0043 16.8 5.5 0.0047 16.7 3.8 1.0 1 0 0 1 1 1 1 rRNA processing DUF2098 PF09871.4 ESA12005.1 - 0.41 10.6 2.9 0.46 10.4 2.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) APG6 PF04111.7 ESA12005.1 - 0.46 9.4 3.5 0.53 9.2 2.4 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 TFIID-18kDa PF02269.11 ESA12006.1 - 3.3e-33 113.3 0.2 1e-32 111.7 0.1 1.8 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Pkinase_Tyr PF07714.12 ESA12011.1 - 6.1e-24 84.4 0.0 1.5e-14 53.7 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA12011.1 - 7.2e-17 61.3 7.8 8.1e-15 54.6 0.7 3.2 2 1 0 3 3 3 2 Protein kinase domain BCS1_N PF08740.6 ESA12011.1 - 8.2e-08 32.0 0.2 0.23 11.0 0.0 3.3 3 0 0 3 3 3 3 BCS1 N terminal WaaY PF06176.6 ESA12011.1 - 0.00014 21.1 0.7 0.00014 21.1 0.5 1.9 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) DUF2439 PF10382.4 ESA12011.1 - 0.00092 19.3 3.3 0.38 10.9 0.0 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2439) Spt5-NGN PF03439.8 ESA12011.1 - 0.008 15.9 0.6 31 4.4 0.0 3.7 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section APH PF01636.18 ESA12011.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Thioredoxin_7 PF13899.1 ESA12011.1 - 3.8 7.5 6.3 70 3.5 0.4 3.9 3 1 1 4 4 4 0 Thioredoxin-like p450 PF00067.17 ESA12012.1 - 4e-27 94.8 0.0 4.4e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dimer_Tnp_hAT PF05699.9 ESA12013.1 - 1e-17 63.5 0.5 1.1e-17 63.3 0.3 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region UCH PF00443.24 ESA12014.1 - 1e-50 172.3 1.3 1.9e-50 171.4 0.9 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.26 ESA12014.1 - 9.7e-24 82.5 0.1 3.5e-12 45.7 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.14 ESA12014.1 - 3.4e-22 78.3 9.5 1.1e-17 63.8 1.9 3.6 4 0 0 4 4 4 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 ESA12014.1 - 4.7e-22 78.7 10.4 5.8e-14 52.2 3.0 2.8 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase F-box-like PF12937.2 ESA12016.1 - 1.5e-05 24.6 0.5 4.8e-05 22.9 0.3 1.8 1 0 0 1 1 1 1 F-box-like Sel1 PF08238.7 ESA12017.1 - 1e-08 35.5 0.1 1.1e-05 25.8 0.0 2.2 2 0 0 2 2 2 2 Sel1 repeat HS1_rep PF02218.10 ESA12017.1 - 0.04 13.7 0.3 0.057 13.3 0.2 1.3 1 0 0 1 1 1 0 Repeat in HS1/Cortactin Lipoprotein_10 PF03202.8 ESA12017.1 - 0.12 12.3 0.6 0.16 12.0 0.2 1.4 1 1 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region F-box-like PF12937.2 ESA12019.1 - 0.0014 18.3 1.4 0.0045 16.6 0.9 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA12019.1 - 0.011 15.3 0.1 0.011 15.3 0.1 3.1 3 0 0 3 3 3 0 F-box domain NAD_binding_4 PF07993.7 ESA12020.1 - 4e-25 88.1 0.0 8.3e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein zf-CCHC PF00098.18 ESA12021.1 - 1.6e-05 24.6 2.1 3.5e-05 23.5 1.4 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 ESA12021.1 - 0.0041 16.7 2.4 0.0044 16.6 0.6 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_6 PF15288.1 ESA12021.1 - 0.019 14.5 0.7 0.046 13.3 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle Sec66 PF09802.4 ESA12022.1 - 0.031 13.6 0.1 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Imm35 PF15581.1 ESA12024.1 - 0.011 15.7 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 35 Alpha_kinase PF02816.13 ESA12025.1 - 1.7e-38 132.2 0.2 2.7e-38 131.5 0.1 1.4 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA12025.1 - 6.7e-08 32.8 0.0 9.9e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Baculo_p33 PF05214.7 ESA12025.1 - 0.033 13.4 0.2 0.086 12.1 0.1 1.7 1 0 0 1 1 1 0 Baculovirus P33 RRM_1 PF00076.17 ESA12026.1 - 0.03 13.9 0.1 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FlxA PF14282.1 ESA12026.1 - 0.062 13.2 0.2 0.062 13.2 0.1 1.9 2 0 0 2 2 2 0 FlxA-like protein Syntaxin-6_N PF09177.6 ESA12026.1 - 0.18 12.2 1.9 0.42 11.0 0.3 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Corona_nucleoca PF00937.13 ESA12026.1 - 0.19 10.6 7.2 0.26 10.1 5.0 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Sel1 PF08238.7 ESA12029.1 - 6e-11 42.6 0.8 1.9e-07 31.4 0.1 2.1 2 0 0 2 2 2 2 Sel1 repeat ImmE5 PF11480.3 ESA12029.1 - 0.14 11.9 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 Colicin-E5 Imm protein TPR_8 PF13181.1 ESA12029.1 - 1.3 8.9 4.2 8.3 6.4 0.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA12030.1 - 3.2e-06 26.7 1.6 8.1e-06 25.4 1.1 1.6 1 0 0 1 1 1 1 F-box-like Pkinase_Tyr PF07714.12 ESA12031.1 - 1.2e-28 99.9 0.0 1.7e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12031.1 - 1.4e-28 99.8 3.7 3.6e-28 98.4 2.6 1.7 1 1 0 1 1 1 1 Protein kinase domain Peptidase_M9_N PF08453.5 ESA12031.1 - 0.00034 20.0 0.1 0.00068 19.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M9 N-terminal APH PF01636.18 ESA12031.1 - 0.21 11.2 1.2 0.35 10.5 0.8 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Piwi PF02171.12 ESA12032.1 - 3.7e-101 338.0 0.0 5.2e-101 337.6 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA12032.1 - 3.2e-25 87.9 0.1 6.1e-25 87.0 0.1 1.4 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA12032.1 - 2.7e-17 61.8 0.0 5.9e-17 60.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Drf_GBD PF06371.8 ESA12033.1 - 1.5 8.1 4.2 1.5 8.1 2.4 1.3 1 1 0 1 1 1 0 Diaphanous GTPase-binding Domain Nucleo_P87 PF07267.6 ESA12033.1 - 3.2 6.3 12.4 3.7 6.1 8.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Hid1 PF12722.2 ESA12033.1 - 4.3 4.9 13.7 4.9 4.7 9.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2508 PF10704.4 ESA12034.1 - 0.0088 16.1 0.4 0.021 14.9 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2508) zf-Di19 PF05605.7 ESA12034.1 - 0.031 14.4 2.5 0.047 13.8 1.7 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESA12034.1 - 0.035 14.4 1.4 0.064 13.6 1.0 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type NOP5NT PF08156.8 ESA12034.1 - 0.14 12.3 1.7 0.26 11.4 1.2 1.5 1 0 0 1 1 1 0 NOP5NT (NUC127) domain ECIST_Cterm PF14784.1 ESA12034.1 - 0.28 11.1 2.7 0.36 10.7 1.9 1.2 1 0 0 1 1 1 0 C-terminal domain of the ECSIT protein zf-C2H2_6 PF13912.1 ESA12034.1 - 0.44 10.5 4.9 0.82 9.6 3.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1664 PF07889.7 ESA12034.1 - 0.63 9.8 2.4 4.6 7.0 0.4 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) PseudoU_synth_2 PF00849.17 ESA12036.1 - 2e-07 30.9 0.0 2.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Sialidase PF02973.11 ESA12038.1 - 0.037 13.0 3.4 0.047 12.6 2.3 1.1 1 0 0 1 1 1 0 Sialidase, N-terminal domain DUF3750 PF12570.3 ESA12038.1 - 0.057 13.6 0.3 0.064 13.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3750) Cmc1 PF08583.5 ESA12039.1 - 2e-17 62.7 1.2 2.3e-17 62.5 0.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.8 ESA12039.1 - 0.00092 18.5 0.4 0.0024 17.2 0.1 1.6 1 1 1 2 2 2 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.8 ESA12039.1 - 0.0022 17.8 0.4 0.0034 17.2 0.3 1.3 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ESA12039.1 - 0.031 14.3 0.6 5.1 7.2 0.1 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 COX17 PF05051.8 ESA12039.1 - 0.051 13.6 0.5 1.9 8.6 0.0 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Gtr1_RagA PF04670.7 ESA12040.1 - 6.7e-100 333.0 1.4 9.3e-100 332.5 0.9 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 ESA12040.1 - 2.7e-07 29.9 0.0 5.4e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESA12040.1 - 3.2e-07 29.8 0.6 6.4e-07 28.9 0.0 1.8 2 1 1 3 3 3 1 Ras family MMR_HSR1 PF01926.18 ESA12040.1 - 6.4e-05 22.8 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESA12040.1 - 0.00011 22.6 0.2 0.0005 20.5 0.0 2.2 2 1 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 ESA12040.1 - 0.0003 20.2 0.1 0.00065 19.1 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Imm42 PF15601.1 ESA12040.1 - 0.052 12.9 1.6 0.086 12.2 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 42 Mog1 PF04603.7 ESA12041.1 - 1e-20 74.1 0.1 1.1e-20 74.0 0.1 1.0 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Fer4_13 PF13370.1 ESA12042.1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 4Fe-4S single cluster domain DUF1493 PF07377.7 ESA12043.1 - 5.3 7.1 7.3 2 8.5 0.1 3.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1493) zf-BED PF02892.10 ESA12046.1 - 3.2e-06 26.8 3.6 5.2e-06 26.1 2.5 1.4 1 0 0 1 1 1 1 BED zinc finger RhoGEF PF00621.15 ESA12046.1 - 0.067 13.0 0.4 0.12 12.1 0.3 1.3 1 0 0 1 1 1 0 RhoGEF domain DUF3504 PF12012.3 ESA12047.1 - 0.0006 19.6 0.0 0.89 9.3 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3504) DUF3385 PF11865.3 ESA12049.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) DUF3810 PF12725.2 ESA12049.1 - 0.059 12.2 0.2 0.059 12.2 0.1 2.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3810) Hemocyanin_N PF03722.9 ESA12050.1 - 0.048 13.8 0.5 0.096 12.8 0.1 1.6 2 0 0 2 2 2 0 Hemocyanin, all-alpha domain DivIC PF04977.10 ESA12051.1 - 0.0017 17.7 10.4 0.0036 16.7 5.8 2.6 1 1 1 2 2 2 2 Septum formation initiator PMT_C PF11647.3 ESA12051.1 - 0.0035 16.9 2.7 5.6 6.6 0.0 4.5 4 0 0 4 4 4 1 C-terminal region of Pasteurella multocida toxin residues 569-1285 DUF1153 PF06627.6 ESA12051.1 - 0.0052 16.6 1.5 12 5.8 0.0 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1153) BrkDBD PF09607.5 ESA12051.1 - 0.0092 15.5 4.8 5.3 6.6 0.1 4.0 3 0 0 3 3 3 2 Brinker DNA-binding domain DUF3385 PF11865.3 ESA12051.1 - 0.037 13.9 1.7 0.1 12.5 0.3 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) TSC22 PF01166.13 ESA12051.1 - 0.04 13.8 8.4 0.25 11.3 4.8 3.1 1 1 1 2 2 2 0 TSC-22/dip/bun family SAM_1 PF00536.25 ESA12051.1 - 0.15 12.2 2.0 49 4.2 0.0 3.9 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) Homez PF11569.3 ESA12051.1 - 0.18 10.9 4.3 13 4.9 0.0 3.7 4 0 0 4 4 4 0 Homeodomain leucine-zipper encoding, Homez Wbp11 PF09429.5 ESA12051.1 - 0.2 11.6 29.6 0.4 10.6 0.2 5.6 5 0 0 5 5 5 0 WW domain binding protein 11 bZIP_2 PF07716.10 ESA12051.1 - 0.26 11.1 13.9 4.1 7.3 5.0 3.3 1 1 1 2 2 2 0 Basic region leucine zipper bZIP_1 PF00170.16 ESA12051.1 - 2.1 8.3 12.8 0.26 11.2 3.7 3.5 3 1 1 4 4 3 0 bZIP transcription factor TMF_DNA_bd PF12329.3 ESA12051.1 - 6.3 6.6 21.3 0.045 13.5 5.9 4.0 3 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4337 PF14235.1 ESA12051.1 - 9.6 6.0 6.8 1.2 8.9 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Pkinase_Tyr PF07714.12 ESA12052.1 - 3.4e-05 23.0 0.0 9.7e-05 21.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12052.1 - 0.0089 15.2 0.1 0.032 13.3 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain DUF3080 PF11279.3 ESA12052.1 - 0.041 13.0 0.3 0.047 12.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) BACK PF07707.10 ESA12052.1 - 0.1 12.4 0.2 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch DUF4468 PF14730.1 ESA12052.1 - 0.67 9.6 4.6 0.46 10.2 1.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold CTP_synth_N PF06418.9 ESA12053.1 - 2.2e-122 407.4 0.6 3.5e-122 406.7 0.4 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 ESA12053.1 - 2.7e-52 177.0 0.0 5.9e-52 175.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESA12053.1 - 6.6e-06 25.7 0.1 2.2e-05 24.0 0.1 1.9 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 ESA12053.1 - 0.00011 21.6 0.0 0.0003 20.2 0.0 1.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain F-box-like PF12937.2 ESA12055.1 - 0.00012 21.7 0.3 0.00026 20.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like TLD PF07534.11 ESA12056.1 - 0.00089 19.2 0.9 0.0012 18.8 0.6 1.3 1 1 0 1 1 1 1 TLD Rieske PF00355.21 ESA12056.1 - 0.01 15.4 0.2 0.02 14.4 0.1 1.6 1 1 1 2 2 2 0 Rieske [2Fe-2S] domain Strabismus PF06638.6 ESA12057.1 - 0.13 10.5 0.2 0.15 10.3 0.1 1.1 1 0 0 1 1 1 0 Strabismus protein Ins145_P3_rec PF08709.6 ESA12060.1 - 0.093 11.7 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF3754 PF12576.3 ESA12061.1 - 2.2 7.9 7.6 0.45 10.1 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) DnaJ PF00226.26 ESA12062.1 - 6.5e-22 77.0 1.3 1.3e-21 76.1 0.5 1.9 2 0 0 2 2 2 1 DnaJ domain DnaJ-X PF14308.1 ESA12062.1 - 3.4e-16 59.1 10.3 1.5e-08 34.1 0.3 2.8 3 1 1 4 4 4 2 X-domain of DnaJ-containing GvpG PF05120.7 ESA12062.1 - 0.00017 21.3 0.6 0.00045 19.9 0.4 1.7 1 0 0 1 1 1 1 Gas vesicle protein G SHOCT PF09851.4 ESA12062.1 - 0.0034 16.7 0.1 0.0091 15.4 0.1 1.8 1 0 0 1 1 1 1 Short C-terminal domain DMAP_binding PF06464.6 ESA12062.1 - 0.0035 17.9 3.7 0.0035 17.9 2.6 1.9 2 0 0 2 2 2 1 DMAP1-binding Domain Mucin PF01456.12 ESA12066.1 - 0.084 12.6 8.5 0.14 11.9 5.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein CagZ PF09053.5 ESA12068.1 - 0.085 12.1 0.3 0.1 11.9 0.2 1.1 1 0 0 1 1 1 0 CagZ RVT_1 PF00078.22 ESA12069.1 - 0.00039 19.8 0.1 0.00039 19.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4292 PF14125.1 ESA12069.1 - 0.04 13.3 0.1 0.048 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4292) Bac_DnaA PF00308.13 ESA12069.1 - 0.051 13.2 0.0 0.051 13.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial dnaA protein DRAT PF07357.6 ESA12070.1 - 0.018 14.2 0.0 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) SecY PF00344.15 ESA12072.1 - 1e-99 333.7 11.1 1.2e-99 333.5 7.7 1.0 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 ESA12072.1 - 7.3e-08 31.7 0.0 2.1e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 Plug domain of Sec61p QCR10 PF09796.4 ESA12072.1 - 0.027 14.1 0.3 0.8 9.4 0.0 2.8 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) WW PF00397.21 ESA12073.1 - 4.6e-07 29.5 6.5 2e-06 27.5 4.5 2.2 1 0 0 1 1 1 1 WW domain Pkinase PF00069.20 ESA12074.1 - 1.8e-24 86.3 2.0 2.2e-24 86.0 1.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12074.1 - 2e-22 79.5 0.3 2.8e-21 75.7 0.2 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA12074.1 - 0.036 13.7 0.1 0.052 13.2 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family PfkB PF00294.19 ESA12075.1 - 7.3e-15 54.8 0.0 1.2e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Sel1 PF08238.7 ESA12076.1 - 9.8e-20 70.5 4.3 1.2e-10 41.6 0.8 2.1 2 0 0 2 2 2 2 Sel1 repeat TPR_11 PF13414.1 ESA12076.1 - 0.48 10.1 3.1 1 9.0 1.2 2.3 1 1 1 2 2 2 0 TPR repeat TPR_1 PF00515.23 ESA12076.1 - 1.8 8.3 5.7 19 5.0 0.4 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat GRAB PF10375.4 ESA12078.1 - 2e-07 30.3 0.4 6.6e-07 28.7 0.3 2.0 1 0 0 1 1 1 1 GRIP-related Arf-binding domain WEMBL PF05701.6 ESA12078.1 - 1.8 6.9 69.4 0.73 8.2 22.3 2.9 1 1 1 2 2 2 0 Weak chloroplast movement under blue light FUSC PF04632.7 ESA12078.1 - 5.9 5.1 14.3 3.1 6.1 7.7 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family DEAD PF00270.24 ESA12079.1 - 2.3e-41 141.1 0.3 9.3e-41 139.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA12079.1 - 1.9e-18 66.0 0.2 4.8e-18 64.7 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA12079.1 - 9.5e-06 25.5 0.1 7.3e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 ESA12079.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain SNF2_N PF00176.18 ESA12079.1 - 0.012 14.3 0.0 0.025 13.3 0.0 1.5 2 0 0 2 2 2 0 SNF2 family N-terminal domain CMS1 PF14617.1 ESA12079.1 - 0.015 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.1 ESA12079.1 - 0.07 12.8 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Part of AAA domain 4HB_MCP_1 PF12729.2 ESA12080.1 - 0.021 14.1 3.4 0.044 13.1 2.4 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Zip PF02535.17 ESA12080.1 - 0.22 10.4 3.4 0.24 10.3 2.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Protamine_P2 PF00841.14 ESA12080.1 - 0.47 11.0 6.6 0.23 12.0 2.7 1.9 2 0 0 2 2 2 0 Sperm histone P2 XRCC4 PF06632.7 ESA12080.1 - 0.9 8.3 21.8 14 4.3 15.1 2.0 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3373 PF11853.3 ESA12080.1 - 0.92 7.9 4.0 1.1 7.7 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Suf PF05843.9 ESA12080.1 - 1.5 8.4 13.4 2.2 7.9 9.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_S49_N PF08496.5 ESA12080.1 - 5.6 6.7 13.5 5.8 6.6 1.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Myb_DNA-bind_6 PF13921.1 ESA12083.1 - 0.00053 20.0 0.3 0.00053 20.0 0.2 2.6 2 2 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA12083.1 - 0.0013 18.7 0.6 0.0086 16.1 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain DAP3 PF10236.4 ESA12085.1 - 4e-24 85.1 0.0 6.6e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Arch_ATPase PF01637.13 ESA12085.1 - 0.0042 16.8 0.1 0.012 15.3 0.0 1.8 2 0 0 2 2 2 1 Archaeal ATPase Rubredoxin PF00301.15 ESA12088.1 - 0.011 15.5 0.3 0.039 13.8 0.2 2.0 1 0 0 1 1 1 0 Rubredoxin MAS20 PF02064.10 ESA12090.1 - 0.063 13.1 0.1 0.1 12.5 0.1 1.4 1 1 0 1 1 1 0 MAS20 protein import receptor Ribosomal_L37 PF08561.5 ESA12091.1 - 0.023 14.2 4.0 0.75 9.4 0.4 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 AA_permease_2 PF13520.1 ESA12092.1 - 2.9e-54 184.2 42.1 3.7e-54 183.8 29.2 1.2 1 0 0 1 1 1 1 Amino acid permease DUF4381 PF14316.1 ESA12092.1 - 0.087 12.9 3.3 1.8 8.6 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) AA_permease_2 PF13520.1 ESA12093.1 - 2e-55 188.0 40.9 2.5e-55 187.7 28.3 1.0 1 0 0 1 1 1 1 Amino acid permease Alk_phosphatase PF00245.15 ESA12096.1 - 6.4e-106 354.5 0.0 7.6e-106 354.3 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 ESA12096.1 - 0.057 12.7 0.4 0.57 9.5 0.3 2.1 2 0 0 2 2 2 0 Metalloenzyme superfamily EFG_C PF00679.19 ESA12096.1 - 0.059 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Elongation factor G C-terminus DUF706 PF05153.10 ESA12097.1 - 5.7e-120 399.3 2.4 7.1e-120 399.0 1.7 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF706) HD PF01966.17 ESA12097.1 - 0.036 14.0 0.0 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 HD domain SH3_1 PF00018.23 ESA12098.1 - 8.3e-10 37.9 1.0 3e-09 36.1 0.0 2.2 2 0 0 2 2 2 1 SH3 domain Transglut_core PF01841.14 ESA12098.1 - 4e-08 33.4 0.1 7.7e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_9 PF14604.1 ESA12098.1 - 3.8e-07 29.5 0.0 1.4e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.12 ESA12098.1 - 4.2e-06 26.1 0.0 1.2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain DUF59 PF01883.14 ESA12100.1 - 3e-10 39.9 0.1 6.8e-10 38.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF59 Gon7 PF08738.5 ESA12101.1 - 0.036 14.0 0.2 0.081 12.9 0.1 1.5 1 0 0 1 1 1 0 Gon7 family Methyltransf_15 PF09445.5 ESA12101.1 - 0.036 13.6 0.8 0.082 12.4 0.5 1.8 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF2439 PF10382.4 ESA12101.1 - 0.057 13.6 4.6 2.7 8.2 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2439) Baculo_PEP_C PF04513.7 ESA12101.1 - 0.063 13.0 1.9 0.45 10.3 0.7 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlbD PF06289.6 ESA12102.1 - 0.0075 15.6 1.7 7.2 6.0 0.1 3.7 3 0 0 3 3 3 2 Flagellar protein (FlbD) HypA PF01155.14 ESA12102.1 - 0.035 13.7 9.0 0.29 10.8 0.5 3.1 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family ING PF12998.2 ESA12104.1 - 6.2e-14 52.1 8.6 1.3e-13 51.1 6.0 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 ESA12104.1 - 4.9e-09 35.7 9.7 8.6e-09 34.9 6.7 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 ESA12104.1 - 0.0029 17.7 0.2 0.0065 16.5 0.1 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESA12104.1 - 0.052 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain IncA PF04156.9 ESA12104.1 - 1.5 8.3 6.5 0.26 10.8 1.3 1.7 1 1 1 2 2 2 0 IncA protein APG6 PF04111.7 ESA12104.1 - 1.6 7.6 9.5 2 7.3 6.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 SNARE_assoc PF09335.6 ESA12105.1 - 9.2e-15 54.9 0.1 9.2e-15 54.9 0.1 1.8 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF2207 PF09972.4 ESA12105.1 - 0.072 11.6 0.1 0.086 11.4 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FtsX PF02687.16 ESA12105.1 - 1.3 8.8 4.7 1.5 8.6 2.8 1.5 1 1 1 2 2 2 0 FtsX-like permease family RabGAP-TBC PF00566.13 ESA12106.1 - 1.9e-52 177.8 0.1 1.9e-52 177.8 0.1 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF1654 PF07867.6 ESA12106.1 - 0.034 13.5 0.0 0.073 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) Spore-coat_CotD PF11122.3 ESA12107.1 - 0.017 15.4 5.8 0.017 15.4 4.0 1.5 1 1 1 2 2 2 0 Inner spore coat protein D Suf PF05843.9 ESA12110.1 - 6.8e-34 117.8 4.2 1.4e-27 97.1 0.2 5.6 4 2 1 5 5 5 2 Suppressor of forked protein (Suf) Collagen PF01391.13 ESA12110.1 - 0.028 13.9 5.5 0.046 13.2 3.8 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) HTH_Tnp_Tc3_2 PF01498.13 ESA12111.1 - 6.6e-06 26.0 0.9 1.3e-05 25.1 0.6 1.4 1 0 0 1 1 1 1 Transposase HTH_21 PF13276.1 ESA12111.1 - 0.055 13.4 1.3 0.081 12.9 0.1 1.8 2 0 0 2 2 2 0 HTH-like domain Pox_RNA_pol_35 PF03396.10 ESA12114.1 - 0.034 13.1 1.2 0.036 13.1 0.1 1.6 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 35 kD subunit zf-H2C2_2 PF13465.1 ESA12116.1 - 5e-09 36.0 6.5 3.8e-07 30.0 1.0 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 ESA12116.1 - 3.4e-08 33.3 8.9 2.1e-06 27.6 0.4 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA12116.1 - 1.8e-07 30.9 7.5 6.2e-07 29.3 0.4 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA12116.1 - 0.0031 17.5 3.6 0.0031 17.5 2.5 2.8 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 ESA12116.1 - 0.0053 16.8 1.3 0.0067 16.5 0.9 1.2 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.10 ESA12116.1 - 0.012 14.9 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Evr1_Alr PF04777.8 ESA12116.1 - 0.018 14.9 0.1 0.018 14.9 0.1 1.1 1 0 0 1 1 1 0 Erv1 / Alr family zf-BED PF02892.10 ESA12116.1 - 0.03 14.0 0.3 0.03 14.0 0.2 1.9 1 1 1 2 2 2 0 BED zinc finger zf-C2HC_2 PF13913.1 ESA12116.1 - 0.041 13.5 1.6 0.07 12.8 0.1 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Thioredoxin_2 PF13098.1 ESA12116.1 - 0.046 13.9 0.2 0.055 13.6 0.2 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain zf-Di19 PF05605.7 ESA12116.1 - 0.056 13.5 0.2 0.089 12.9 0.1 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Toxin-deaminase PF14424.1 ESA12116.1 - 0.099 12.6 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Pox_E10 PF04805.7 ESA12116.1 - 0.13 11.8 0.7 0.17 11.3 0.5 1.4 1 1 0 1 1 1 0 E10-like protein conserved region BolA PF01722.13 ESA12116.1 - 0.31 11.0 1.9 2.5 8.0 0.1 2.0 1 1 1 2 2 2 0 BolA-like protein zf-C2H2_6 PF13912.1 ESA12116.1 - 0.34 10.8 0.2 0.34 10.8 0.1 2.1 3 0 0 3 3 2 0 C2H2-type zinc finger Ribosomal_L35p PF01632.14 ESA12116.1 - 0.54 10.1 4.9 0.49 10.3 0.3 2.0 1 1 1 2 2 2 0 Ribosomal protein L35 zf-H2C2_5 PF13909.1 ESA12116.1 - 1 9.7 7.3 1.2 9.4 0.6 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF2737 PF10930.3 ESA12117.1 - 0.23 11.1 2.1 2.4 7.8 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2737) Complex1_LYR_1 PF13232.1 ESA12117.1 - 0.41 10.8 2.5 0.4 10.9 0.8 1.7 2 0 0 2 2 2 0 Complex1_LYR-like Mtc PF03820.12 ESA12118.1 - 2.8e-05 22.9 0.0 3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier DSPc PF00782.15 ESA12119.1 - 1.5e-35 121.6 0.5 1.5e-35 121.6 0.3 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA12119.1 - 6.9e-06 25.5 0.6 6.9e-06 25.5 0.4 1.9 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESA12119.1 - 0.0094 15.9 2.2 0.025 14.6 1.5 2.0 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.8 ESA12119.1 - 0.0096 15.2 0.4 0.023 14.0 0.1 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESA12119.1 - 0.095 12.9 0.2 0.31 11.2 0.0 2.0 1 1 0 2 2 2 0 Tyrosine phosphatase family TPR_1 PF00515.23 ESA12121.1 - 2.7e-08 33.0 0.3 0.0057 16.2 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA12121.1 - 8.4e-06 25.3 0.1 1.9e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 ESA12121.1 - 0.00011 21.8 0.0 0.73 9.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA12121.1 - 0.0021 17.8 0.1 0.35 10.7 0.0 2.3 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.1 ESA12121.1 - 0.0095 16.2 0.3 0.083 13.2 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA12121.1 - 0.017 14.8 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M74 PF03411.8 ESA12121.1 - 0.037 13.2 0.1 0.043 13.0 0.1 1.1 1 0 0 1 1 1 0 Penicillin-insensitive murein endopeptidase TPR_17 PF13431.1 ESA12121.1 - 0.071 13.3 0.0 0.24 11.7 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3646 PF12362.3 ESA12121.1 - 0.079 12.9 1.1 0.13 12.2 0.8 1.3 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal YecM PF06185.7 ESA12121.1 - 0.1 11.7 0.2 1.5 7.9 0.0 2.2 2 1 0 2 2 2 0 YecM protein DUF3835 PF12927.2 ESA12121.1 - 0.11 13.4 1.7 0.46 11.4 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3835) Mac PF12464.3 ESA12121.1 - 0.13 12.2 0.1 0.31 11.0 0.1 1.7 1 1 0 1 1 1 0 Maltose acetyltransferase Methyltrans_Mon PF14314.1 ESA12121.1 - 0.18 9.6 0.8 0.21 9.3 0.6 1.0 1 0 0 1 1 1 0 Virus-capping methyltransferase Spore_III_AB PF09548.5 ESA12124.1 - 1.3e-05 25.0 2.8 0.00013 21.7 0.1 2.0 1 1 1 2 2 2 1 Stage III sporulation protein AB (spore_III_AB) DUF1664 PF07889.7 ESA12124.1 - 5.6e-05 22.9 7.9 0.00081 19.1 2.1 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) LXG PF04740.7 ESA12124.1 - 0.00016 21.5 10.1 0.00022 21.1 7.0 1.2 1 0 0 1 1 1 1 LXG domain of WXG superfamily Baculo_PEP_C PF04513.7 ESA12124.1 - 0.00033 20.4 6.6 0.00033 20.4 4.6 2.0 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF677 PF05055.7 ESA12124.1 - 0.0054 15.4 0.7 0.021 13.5 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF677) WXG100 PF06013.7 ESA12124.1 - 0.0072 16.3 8.1 0.047 13.7 4.2 2.8 2 1 0 2 2 2 1 Proteins of 100 residues with WXG Apolipoprotein PF01442.13 ESA12124.1 - 0.008 15.7 0.2 0.015 14.8 0.1 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain FH2 PF02181.18 ESA12124.1 - 0.0086 14.9 0.3 0.013 14.4 0.2 1.3 1 1 0 1 1 1 1 Formin Homology 2 Domain DUF713 PF05218.9 ESA12124.1 - 0.0089 15.7 6.4 0.0095 15.6 2.6 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF713) Allexi_40kDa PF05549.6 ESA12124.1 - 0.012 14.9 1.9 0.015 14.6 0.9 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein TBPIP PF07106.8 ESA12124.1 - 0.015 14.8 7.1 0.068 12.7 1.2 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) COG2 PF06148.6 ESA12124.1 - 0.021 14.6 3.4 1.2 9.0 0.4 2.8 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2408 PF10303.4 ESA12124.1 - 0.025 14.6 4.4 0.24 11.4 3.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) IncA PF04156.9 ESA12124.1 - 0.026 14.1 4.3 0.18 11.3 3.0 1.9 1 1 0 1 1 1 0 IncA protein Syntaxin-6_N PF09177.6 ESA12124.1 - 0.029 14.7 5.6 0.11 12.8 2.3 2.6 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF2205 PF10224.4 ESA12124.1 - 0.033 13.7 4.3 0.28 10.7 0.2 2.6 2 1 1 3 3 3 0 Predicted coiled-coil protein (DUF2205) Sec8_exocyst PF04048.9 ESA12124.1 - 0.041 13.5 8.9 0.077 12.6 1.4 2.7 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain Laminin_II PF06009.7 ESA12124.1 - 0.05 13.3 5.3 0.3 10.8 1.0 2.6 1 1 0 2 2 2 0 Laminin Domain II WEMBL PF05701.6 ESA12124.1 - 0.05 12.0 0.2 0.37 9.1 0.1 1.8 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Sec23_trunk PF04811.10 ESA12124.1 - 0.051 12.9 1.3 0.064 12.6 0.9 1.2 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain Reo_sigmaC PF04582.7 ESA12124.1 - 0.052 12.7 0.4 2.3 7.2 0.1 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF869 PF05911.6 ESA12124.1 - 0.063 11.5 3.2 0.07 11.3 2.2 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Vps5 PF09325.5 ESA12124.1 - 0.13 11.5 1.1 0.59 9.3 0.2 2.1 2 1 1 3 3 3 0 Vps5 C terminal like DASH_Duo1 PF08651.5 ESA12124.1 - 0.14 11.7 6.0 0.56 9.8 0.3 2.7 2 1 1 3 3 3 0 DASH complex subunit Duo1 Bacillus_HBL PF05791.6 ESA12124.1 - 0.14 11.5 11.6 1.9 7.8 0.2 2.6 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Muted PF14942.1 ESA12124.1 - 0.14 11.9 2.2 0.41 10.5 0.7 1.9 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF2959 PF11172.3 ESA12124.1 - 0.15 11.8 2.9 0.39 10.4 1.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) Vps51 PF08700.6 ESA12124.1 - 0.15 11.9 3.1 14 5.6 0.1 2.9 3 0 0 3 3 3 0 Vps51/Vps67 Syntaxin PF00804.20 ESA12124.1 - 0.15 12.2 14.2 0.62 10.2 6.1 2.5 1 1 1 2 2 2 0 Syntaxin COG5 PF10392.4 ESA12124.1 - 0.16 11.9 4.7 0.3 11.0 0.5 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Occludin_ELL PF07303.8 ESA12124.1 - 0.24 12.1 2.2 1.4 9.7 0.3 2.4 1 1 1 2 2 2 0 Occludin homology domain DUF948 PF06103.6 ESA12124.1 - 0.24 11.2 6.1 0.35 10.7 1.1 2.2 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) IFT57 PF10498.4 ESA12124.1 - 0.25 10.0 9.8 0.13 10.9 3.6 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Corona_S2 PF01601.11 ESA12124.1 - 0.29 9.1 6.6 0.31 9.0 4.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein FlaC_arch PF05377.6 ESA12124.1 - 0.37 10.7 9.7 4.6 7.2 0.5 3.4 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) RPW8 PF05659.6 ESA12124.1 - 0.42 10.1 3.2 8.3 5.9 0.3 2.3 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Cytochrom_B562 PF07361.6 ESA12124.1 - 0.42 11.0 1.9 2.1 8.7 0.3 2.3 1 1 1 2 2 2 0 Cytochrome b562 Prefoldin_2 PF01920.15 ESA12124.1 - 0.51 10.1 9.7 3.1 7.6 0.2 3.1 3 0 0 3 3 3 0 Prefoldin subunit NPV_P10 PF05531.7 ESA12124.1 - 0.64 10.3 13.8 3.5 7.9 5.5 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein MCPsignal PF00015.16 ESA12124.1 - 0.72 9.3 5.7 0.5 9.8 0.9 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DegS PF05384.6 ESA12124.1 - 0.81 8.8 5.8 0.7 9.1 0.8 2.5 2 1 0 2 2 2 0 Sensor protein DegS YgaB PF14182.1 ESA12124.1 - 0.87 9.8 13.5 16 5.7 2.5 3.2 1 1 1 3 3 3 0 YgaB-like protein ING PF12998.2 ESA12124.1 - 1.4 9.2 9.9 2.8 8.2 3.3 2.6 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Fib_alpha PF08702.5 ESA12124.1 - 1.6 8.8 11.1 7.2 6.7 3.5 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin PF02996.12 ESA12124.1 - 2.2 7.9 8.2 2.3 7.8 0.3 2.9 3 0 0 3 3 3 0 Prefoldin subunit G_glu_transpept PF01019.16 ESA12125.1 - 3.7e-143 477.6 0.0 4.2e-143 477.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Dimerisation PF08100.6 ESA12125.1 - 0.054 13.3 1.0 5.9 6.8 0.0 3.2 3 0 0 3 3 3 0 Dimerisation domain Pkinase PF00069.20 ESA12128.1 - 6.6e-07 28.7 0.0 7.3e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA12128.1 - 0.0045 16.0 0.1 0.0062 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA12128.1 - 0.0091 14.9 0.0 0.01 14.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA12128.1 - 0.054 13.2 0.1 0.065 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA12128.1 - 0.064 12.3 0.0 0.073 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase APH_6_hur PF04655.9 ESA12128.1 - 0.11 11.6 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Baculo_E25 PF05274.6 ESA12129.1 - 0.018 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein E25 Vma12 PF11712.3 ESA12130.1 - 5.2e-29 100.7 0.3 7.7e-29 100.2 0.2 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4149 PF13664.1 ESA12130.1 - 9.3e-05 22.4 0.1 0.00019 21.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4149) DUF3623 PF12291.3 ESA12130.1 - 0.0021 17.0 0.1 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3623) EmrE PF13536.1 ESA12130.1 - 0.36 11.0 3.2 0.56 10.4 2.2 1.2 1 0 0 1 1 1 0 Multidrug resistance efflux transporter SID PF11778.3 ESA12131.1 - 0.00097 19.0 2.3 0.00097 19.0 1.6 3.6 3 1 1 4 4 4 1 Septation initiation DUF904 PF06005.7 ESA12131.1 - 0.021 15.1 2.8 0.021 15.1 1.9 4.4 1 1 2 3 3 3 0 Protein of unknown function (DUF904) Phage_B PF02304.10 ESA12131.1 - 2 8.7 9.4 0.15 12.3 1.0 2.6 1 1 2 3 3 3 0 Scaffold protein B Pkinase PF00069.20 ESA12132.1 - 6e-23 81.3 0.3 6e-23 81.3 0.2 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12132.1 - 3.8e-22 78.5 0.0 8.3e-22 77.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase BCS1_N PF08740.6 ESA12132.1 - 0.0046 16.5 0.0 0.0079 15.8 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal APH PF01636.18 ESA12132.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA12132.1 - 0.046 12.9 1.2 0.052 12.7 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Orbi_VP1 PF05788.7 ESA12132.1 - 0.054 10.7 0.1 0.06 10.5 0.0 1.1 1 0 0 1 1 1 0 Orbivirus RNA-dependent RNA polymerase (VP1) F-box-like PF12937.2 ESA12133.1 - 0.0056 16.3 1.2 0.015 15.0 0.8 1.8 1 0 0 1 1 1 1 F-box-like RhoGEF PF00621.15 ESA12135.1 - 4.7e-56 189.5 3.8 6.4e-56 189.0 2.7 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.24 ESA12135.1 - 2.9e-09 37.0 0.6 6.8e-09 35.8 0.1 1.9 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 ESA12135.1 - 0.031 14.5 0.2 0.097 12.9 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain MutS_III PF05192.13 ESA12135.1 - 0.14 11.9 0.6 0.26 11.0 0.2 1.7 1 1 0 1 1 1 0 MutS domain III SPX PF03105.14 ESA12135.1 - 0.18 11.5 2.2 0.57 9.9 0.0 2.1 2 0 0 2 2 2 0 SPX domain PX PF00787.19 ESA12135.1 - 0.37 10.5 3.5 0.2 11.4 0.8 1.7 2 0 0 2 2 2 0 PX domain BLOC1_2 PF10046.4 ESA12135.1 - 7.4 6.7 8.0 3.9 7.6 0.4 3.4 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cupredoxin_1 PF13473.1 ESA12137.1 - 0.93 9.4 3.7 20 5.1 0.0 2.5 2 0 0 2 2 2 0 Cupredoxin-like domain Sel1 PF08238.7 ESA12139.1 - 1.9e-07 31.4 0.6 1.1e-05 25.8 0.2 2.1 2 0 0 2 2 2 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA12139.1 - 0.0043 16.8 0.5 0.0062 16.3 0.3 1.3 1 0 0 1 1 1 1 zinc-ribbons DUF2616 PF11077.3 ESA12139.1 - 0.0062 16.0 1.2 0.0066 15.9 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2616) DUF3087 PF11286.3 ESA12139.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) TPR_17 PF13431.1 ESA12139.1 - 0.13 12.4 0.3 0.26 11.5 0.2 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat zf-RING_3 PF14369.1 ESA12139.1 - 0.14 12.2 4.1 0.36 10.8 0.1 2.4 1 1 1 2 2 2 0 zinc-finger Stc1 PF12898.2 ESA12139.1 - 0.21 11.6 3.6 0.29 11.2 2.5 1.4 1 1 0 1 1 1 0 Stc1 domain DUF2256 PF10013.4 ESA12139.1 - 0.32 10.7 3.1 0.62 9.8 2.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Pkinase_Tyr PF07714.12 ESA12140.1 - 3.6e-08 32.7 0.0 0.0067 15.5 0.0 4.4 4 0 0 4 4 4 2 Protein tyrosine kinase Fer4_8 PF13183.1 ESA12140.1 - 3.9e-05 23.5 0.9 15 5.7 0.0 4.3 4 0 0 4 4 4 1 4Fe-4S dicluster domain DUF2789 PF10982.3 ESA12140.1 - 0.0018 18.2 10.1 12 5.9 0.0 5.4 6 0 0 6 6 6 1 Protein of unknown function (DUF2789) zf-4CXXC_R1 PF10497.4 ESA12140.1 - 0.13 12.3 9.1 25 5.0 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger domain of monoamine-oxidase A repressor R1 MafB19-deam PF14437.1 ESA12140.1 - 0.15 11.6 7.4 5.3 6.6 0.1 3.9 4 0 0 4 4 4 0 MafB19-like deaminase DUF2535 PF10751.4 ESA12140.1 - 0.35 11.0 14.8 2.8 8.1 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2535) Hyccin PF09790.4 ESA12140.1 - 0.58 8.9 7.8 20 3.9 0.1 3.9 4 0 0 4 4 4 0 Hyccin ACDC PF14733.1 ESA12140.1 - 8 6.6 10.9 10 6.3 0.1 3.8 4 0 0 4 4 4 0 AP2-coincident C-terminal TLD PF07534.11 ESA12141.1 - 1.7e-13 50.7 0.1 1.7e-13 50.7 0.0 2.6 3 0 0 3 3 3 1 TLD DUF1752 PF08550.5 ESA12143.1 - 1.2e-12 47.2 3.9 2.7e-12 46.0 2.7 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF3439 PF11921.3 ESA12143.1 - 8.4 6.1 18.5 2.9 7.6 8.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) WAPL PF07814.8 ESA12146.1 - 9.3e-18 64.0 13.2 9.3e-18 64.0 9.1 1.9 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin AAA_17 PF13207.1 ESA12147.1 - 1.3e-05 25.9 3.7 6.6e-05 23.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 ESA12147.1 - 3.5e-05 23.7 0.8 0.00011 22.1 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA12147.1 - 6.4e-05 22.1 4.2 0.19 10.8 0.4 3.1 2 1 1 3 3 3 2 AIG1 family ABC_tran PF00005.22 ESA12147.1 - 0.0021 18.3 0.3 0.0048 17.2 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.1 ESA12147.1 - 0.0072 16.6 6.7 0.015 15.5 0.0 2.7 2 1 1 3 3 3 1 AAA domain PduV-EutP PF10662.4 ESA12147.1 - 0.008 15.6 0.1 0.018 14.5 0.1 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.11 ESA12147.1 - 0.022 13.9 0.0 0.041 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESA12147.1 - 0.029 13.6 0.4 0.88 8.8 0.1 2.3 1 1 1 2 2 2 0 Ferrous iron transport protein B MobB PF03205.9 ESA12147.1 - 0.071 12.8 0.9 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 ESA12147.1 - 0.079 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ESA12147.1 - 0.11 12.0 0.1 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fumerase_C PF05683.7 ESA12147.1 - 0.11 11.5 0.1 0.19 10.8 0.1 1.3 1 0 0 1 1 1 0 Fumarase C-terminus Dynamin_N PF00350.18 ESA12147.1 - 0.12 12.2 2.0 0.22 11.3 0.1 2.2 2 1 0 2 2 2 0 Dynamin family T2SE PF00437.15 ESA12147.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.1 ESA12147.1 - 0.14 12.0 0.1 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain DDE_3 PF13358.1 ESA12148.1 - 8.3e-10 38.5 0.0 9.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.20 ESA12149.1 - 6.4e-31 107.4 0.1 8.7e-31 107.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12149.1 - 2.1e-28 99.1 0.0 2.6e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA12149.1 - 0.017 14.8 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BAH PF01426.13 ESA12150.1 - 0.0023 17.6 0.5 0.47 10.2 0.0 2.9 2 1 0 2 2 2 2 BAH domain Piwi PF02171.12 ESA12151.1 - 3.5e-28 98.4 0.1 5.4e-28 97.8 0.1 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA12151.1 - 4.8e-20 71.2 1.5 4.8e-20 71.2 1.0 1.7 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ESA12151.1 - 1.6e-12 46.5 0.0 3.8e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Herpes_LMP1 PF05297.6 ESA12152.1 - 0.00033 19.6 38.5 0.036 12.9 8.5 3.0 1 1 2 3 3 3 3 Herpesvirus latent membrane protein 1 (LMP1) NnrS PF05940.7 ESA12153.1 - 0.029 13.3 0.0 0.029 13.3 0.0 1.0 1 0 0 1 1 1 0 NnrS protein RicinB_lectin_2 PF14200.1 ESA12154.1 - 0.00058 20.2 0.1 0.0057 17.0 0.1 2.2 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like p450 PF00067.17 ESA12158.1 - 3.9e-77 259.7 1.7 4.5e-77 259.5 1.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 MBOAT_2 PF13813.1 ESA12159.1 - 2e-11 43.7 1.3 6.8e-11 42.1 1.0 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family DUF1700 PF08006.6 ESA12161.1 - 0.34 10.1 1.4 0.61 9.3 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) MIF4G PF02854.14 ESA12161.1 - 0.34 10.2 7.9 0.23 10.8 0.6 2.6 1 1 1 2 2 2 0 MIF4G domain GOLD_2 PF13897.1 ESA12161.1 - 1.3 9.2 12.4 1 9.5 1.5 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking DUF566 PF04484.7 ESA12162.1 - 0.44 10.0 9.6 0.57 9.6 6.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) RP-C_C PF11800.3 ESA12162.1 - 6.8 6.3 6.9 11 5.6 4.7 1.4 1 1 0 1 1 1 0 Replication protein C C-terminal region Macoilin PF09726.4 ESA12162.1 - 7.7 4.6 11.0 9.3 4.3 7.6 1.1 1 0 0 1 1 1 0 Transmembrane protein RRM_1 PF00076.17 ESA12163.1 - 1.7e-05 24.3 0.0 1.8e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA12163.1 - 0.086 12.8 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SGS PF05002.10 ESA12164.1 - 0.039 13.6 0.3 0.067 12.9 0.2 1.3 1 0 0 1 1 1 0 SGS domain Mss4 PF04421.8 ESA12164.1 - 2.1 8.2 5.6 88 3.0 3.9 2.2 1 1 0 1 1 1 0 Mss4 protein DUF2870 PF11069.3 ESA12165.1 - 1.1 9.3 4.6 13 5.9 1.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2870) UQ_con PF00179.21 ESA12166.1 - 1.7e-11 43.7 0.1 1.8e-11 43.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA12166.1 - 0.015 15.2 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 0 RWD domain Arrestin_N PF00339.24 ESA12168.1 - 3.1e-06 27.0 0.0 4.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Kelch_5 PF13854.1 ESA12169.1 - 4.3e-21 74.4 3.9 6.9e-05 22.7 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.1 ESA12169.1 - 1.1e-20 73.1 11.7 0.0002 21.0 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA12169.1 - 6.7e-17 61.1 14.1 0.00011 22.1 0.1 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA12169.1 - 1.5e-11 43.9 12.9 0.0025 17.9 0.0 5.4 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ESA12169.1 - 1.9e-10 40.1 5.2 0.0057 16.3 0.0 5.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESA12169.1 - 5.7e-10 38.5 11.0 0.00012 21.4 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Rax2 PF12768.2 ESA12169.1 - 0.053 12.7 0.9 1.2 8.2 0.0 2.6 1 1 1 2 2 2 0 Cortical protein marker for cell polarity PLDc PF00614.17 ESA12169.1 - 0.076 12.8 0.7 0.55 10.1 0.2 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif Mss4 PF04421.8 ESA12169.1 - 0.11 12.3 0.0 0.51 10.1 0.0 2.1 2 0 0 2 2 2 0 Mss4 protein Beta-APP PF03494.8 ESA12169.1 - 1.2 8.6 4.4 2.4 7.6 3.0 1.5 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) DUF4419 PF14388.1 ESA12170.1 - 5.7e-77 258.8 0.1 8.1e-77 258.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Pcc1 PF09341.5 ESA12170.1 - 0.054 13.5 0.0 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 Transcription factor Pcc1 Syja_N PF02383.13 ESA12171.1 - 1.9e-87 293.0 0.1 2.9e-87 292.4 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 ESA12171.1 - 1.5e-25 90.5 0.0 2.6e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pantoate_ligase PF02569.10 ESA12171.1 - 0.026 13.2 0.0 0.045 12.5 0.0 1.3 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Vps52 PF04129.7 ESA12172.1 - 4.6e-147 490.6 19.9 4.6e-147 490.6 13.8 1.6 2 0 0 2 2 2 1 Vps52 / Sac2 family Sec3_C PF09763.4 ESA12172.1 - 1.1e-05 23.8 18.4 0.0002 19.6 9.6 2.8 1 1 0 2 2 2 2 Exocyst complex component Sec3 COG2 PF06148.6 ESA12172.1 - 0.0021 17.9 3.0 0.0021 17.9 2.1 2.9 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 nsp7 PF08716.5 ESA12172.1 - 0.028 14.8 0.2 0.1 12.9 0.1 2.0 1 0 0 1 1 1 0 nsp7 replicase CENP-F_leu_zip PF10473.4 ESA12172.1 - 1.1 9.1 7.2 0.31 10.8 2.1 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sec8_exocyst PF04048.9 ESA12172.1 - 2.8 7.5 9.0 0.23 11.1 1.8 2.5 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain FH2 PF02181.18 ESA12173.1 - 1.4e-17 63.6 0.5 1.4e-17 63.6 0.3 1.6 1 1 1 2 2 2 1 Formin Homology 2 Domain DUF3534 PF12053.3 ESA12173.1 - 0.0024 17.7 0.4 0.0067 16.3 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF3534) Sec23_trunk PF04811.10 ESA12173.1 - 0.003 16.9 0.3 0.0037 16.6 0.2 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain FlaC_arch PF05377.6 ESA12173.1 - 0.0033 17.3 13.4 0.14 12.1 0.5 3.2 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) Cohesin_load PF10345.4 ESA12173.1 - 0.0039 15.4 1.7 0.0048 15.1 1.2 1.1 1 0 0 1 1 1 1 Cohesin loading factor TFIID_20kDa PF03847.8 ESA12173.1 - 0.011 15.9 0.6 0.28 11.5 0.1 2.8 1 1 1 2 2 2 0 Transcription initiation factor TFIID subunit A DUF247 PF03140.10 ESA12173.1 - 0.031 13.3 0.3 0.037 13.0 0.2 1.1 1 0 0 1 1 1 0 Plant protein of unknown function NAD_binding_5 PF07994.7 ESA12173.1 - 0.033 13.6 0.7 0.047 13.1 0.4 1.3 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase CENP-H PF05837.7 ESA12173.1 - 0.041 14.0 7.7 0.31 11.2 1.7 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ALMT PF11744.3 ESA12173.1 - 0.059 12.0 0.5 0.075 11.6 0.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MutS_IV PF05190.13 ESA12173.1 - 0.1 12.7 3.6 2.7 8.2 0.1 2.4 2 1 0 2 2 2 0 MutS family domain IV ISG65-75 PF11727.3 ESA12173.1 - 0.18 10.8 1.3 0.29 10.1 0.3 1.7 1 1 1 2 2 2 0 Invariant surface glycoprotein Cas_DxTHG PF09455.5 ESA12173.1 - 0.21 10.6 7.1 0.33 10.0 4.9 1.3 1 1 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family BMFP PF04380.8 ESA12173.1 - 0.24 11.5 3.3 4.6 7.4 0.2 2.7 2 1 1 3 3 3 0 Membrane fusogenic activity WEMBL PF05701.6 ESA12173.1 - 0.26 9.7 8.8 1.9 6.8 3.9 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light CorA PF01544.13 ESA12173.1 - 0.3 10.1 4.3 0.26 10.3 0.9 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF2802 PF10975.3 ESA12173.1 - 0.53 10.0 2.5 12 5.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) Lebercilin PF15619.1 ESA12173.1 - 0.97 8.8 7.5 0.12 11.7 0.6 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.7 ESA12173.1 - 0.97 9.2 5.2 0.95 9.2 1.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MCPsignal PF00015.16 ESA12173.1 - 1.1 8.6 5.5 0.54 9.7 1.3 1.7 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Fib_alpha PF08702.5 ESA12173.1 - 1.3 9.1 8.2 5.3 7.1 5.2 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin PF00804.20 ESA12173.1 - 2.6 8.2 10.6 19 5.4 2.9 2.9 2 1 0 2 2 2 0 Syntaxin Curto_V2 PF07325.6 ESA12174.1 - 0.048 13.3 0.0 9 5.9 0.0 2.2 2 0 0 2 2 2 0 Curtovirus V2 protein HPD PF05044.7 ESA12175.1 - 0.12 12.0 2.6 0.77 9.4 0.4 2.1 1 1 1 2 2 2 0 Homeo-prospero domain UPF0228 PF05727.6 ESA12175.1 - 0.4 10.4 3.9 0.22 11.2 1.4 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0228) HPD PF05044.7 ESA12176.1 - 0.018 14.7 5.5 1.2 8.7 0.4 2.1 1 1 1 2 2 2 0 Homeo-prospero domain Apocytochr_F_C PF01333.14 ESA12176.1 - 0.043 13.6 0.9 3.9 7.3 0.0 2.4 1 1 0 2 2 2 0 Apocytochrome F, C-terminal Microtub_assoc PF07989.6 ESA12176.1 - 1.3 8.9 9.6 1.4 8.7 1.1 2.4 1 1 1 2 2 2 0 Microtubule associated Lin-8 PF03353.10 ESA12176.1 - 2.2 7.5 10.8 2.8 7.1 7.5 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Lipocalin_4 PF13648.1 ESA12176.1 - 3.8 8.1 5.9 8.7 7.0 4.1 1.6 1 1 0 1 1 1 0 Lipocalin-like domain Sec62 PF03839.11 ESA12176.1 - 4 6.7 9.8 4.7 6.5 6.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SPOR PF05036.8 ESA12177.1 - 0.069 13.3 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Sporulation related domain MFS_1 PF07690.11 ESA12178.1 - 4.5e-19 68.3 39.8 6.2e-18 64.6 14.8 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily Bacteriocin_IIc PF10439.4 ESA12178.1 - 7.5 6.7 6.4 8.2 6.6 1.4 2.7 2 1 1 3 3 3 0 Bacteriocin class II with double-glycine leader peptide DUF3278 PF11683.3 ESA12178.1 - 9.3 6.2 9.8 0.14 12.1 0.3 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3278) LRR_4 PF12799.2 ESA12181.1 - 0.024 14.2 18.6 0.18 11.4 1.1 4.1 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA12181.1 - 0.031 14.0 18.0 0.18 11.5 0.2 5.1 5 1 2 7 7 7 0 Leucine rich repeat Tim17 PF02466.14 ESA12182.1 - 8.7e-40 135.7 1.8 9e-40 135.6 1.2 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_Omp PF13488.1 ESA12182.1 - 0.00026 20.5 0.7 0.0014 18.1 0.0 2.0 2 0 0 2 2 2 1 Glycine zipper Bacteriocin_IIc PF10439.4 ESA12182.1 - 0.27 11.3 3.4 0.29 11.2 0.8 1.8 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide V-ATPase_C PF03223.10 ESA12183.1 - 2.1e-129 431.6 7.7 2.4e-129 431.5 5.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C UBA_e1_C PF09358.5 ESA12183.1 - 0.079 13.1 1.2 0.19 11.8 0.8 1.7 1 0 0 1 1 1 0 Ubiquitin-activating enzyme e1 C-terminal domain Nup84_Nup100 PF04121.8 ESA12184.1 - 2e-103 346.4 25.7 2.7e-103 345.9 17.8 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 BEX PF04538.7 ESA12187.1 - 0.014 15.5 0.9 0.019 15.1 0.6 1.2 1 0 0 1 1 1 0 Brain expressed X-linked like family CNH PF00780.17 ESA12188.1 - 1.7e-38 132.6 0.0 2.5e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.4 ESA12188.1 - 7.9e-29 99.8 0.1 2.7e-28 98.1 0.1 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.15 ESA12188.1 - 0.0039 16.8 2.2 0.13 11.8 0.0 2.9 3 0 0 3 3 3 1 Region in Clathrin and VPS Apc3 PF12895.2 ESA12188.1 - 0.017 15.2 0.0 0.043 13.9 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA12188.1 - 0.021 15.1 0.1 0.058 13.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA12188.1 - 0.13 12.2 0.5 4.8 7.1 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA12188.1 - 0.18 12.5 0.1 1.2 9.9 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA12189.1 - 9.8e-09 34.6 0.0 0.0026 16.8 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA12189.1 - 2.6e-05 23.5 0.0 0.042 12.9 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Cu-binding_MopE PF11617.3 ESA12189.1 - 0.086 12.6 2.7 0.43 10.4 0.1 2.4 2 0 0 2 2 2 0 Protein metal binding site Spindle_Spc25 PF08234.7 ESA12191.1 - 0.037 14.0 0.2 0.21 11.6 0.1 2.0 1 1 1 2 2 2 0 Chromosome segregation protein Spc25 Miff PF05644.6 ESA12191.1 - 0.13 11.8 2.5 0.17 11.4 1.8 1.2 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Neur_chan_memb PF02932.11 ESA12191.1 - 0.29 11.0 1.8 0.33 10.7 1.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region F-box-like PF12937.2 ESA12192.1 - 1.8e-05 24.3 4.2 5.3e-05 22.8 2.9 1.9 1 0 0 1 1 1 1 F-box-like Phage_holin_1 PF04531.8 ESA12192.1 - 0.084 12.9 0.8 0.21 11.6 0.2 2.0 2 0 0 2 2 2 0 Bacteriophage holin F-box-like PF12937.2 ESA12193.1 - 0.002 17.8 3.5 0.002 17.8 2.4 2.6 3 0 0 3 3 3 1 F-box-like Pox_A3L PF05288.6 ESA12193.1 - 0.052 13.2 0.2 0.21 11.3 0.2 2.0 1 0 0 1 1 1 0 Poxvirus A3L Protein Exotox-A_target PF09102.5 ESA12194.1 - 0.14 11.6 0.0 0.61 9.5 0.0 1.9 2 0 0 2 2 2 0 Exotoxin A, targeting Dynamin_M PF01031.15 ESA12201.1 - 3.8e-42 144.0 1.4 6.3e-40 136.7 0.9 2.6 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 ESA12201.1 - 7.6e-30 103.9 1.7 2.3e-29 102.3 0.0 2.7 2 2 0 2 2 2 1 Dynamin family GED PF02212.13 ESA12201.1 - 4e-09 36.2 2.8 5.2e-09 35.8 0.1 2.6 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 ESA12201.1 - 4.5e-05 23.3 0.6 0.0009 19.1 0.4 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.1 ESA12201.1 - 0.034 14.1 0.0 0.034 14.1 0.0 4.3 2 1 1 4 4 4 0 AAA domain ABC_tran PF00005.22 ESA12201.1 - 0.038 14.2 0.0 0.26 11.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Miro PF08477.8 ESA12201.1 - 0.063 13.7 0.0 0.24 11.8 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 ESA12201.1 - 0.081 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cyclin PF08613.6 ESA12202.1 - 1.8e-07 31.6 2.4 1.4e-06 28.7 0.0 2.8 2 1 0 2 2 2 1 Cyclin HTH_19 PF12844.2 ESA12202.1 - 0.27 11.3 2.4 0.74 9.9 1.7 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Alg14 PF08660.6 ESA12202.1 - 1.6 8.7 5.2 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like zf-BED PF02892.10 ESA12203.1 - 1.4e-10 40.7 2.6 1.9e-10 40.3 1.8 1.2 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA12203.1 - 0.017 15.3 0.2 0.044 14.1 0.1 1.7 1 1 0 1 1 1 0 C2H2-type zinc finger UDPG_MGDP_dh_C PF03720.10 ESA12205.1 - 1.4e-36 124.8 0.4 2.1e-36 124.2 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 ESA12205.1 - 2.9e-27 94.7 0.2 7.9e-27 93.3 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_7 PF13241.1 ESA12205.1 - 0.045 14.0 0.1 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Dus PF01207.12 ESA12206.1 - 3.6e-48 163.9 0.0 4.5e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) BTB PF00651.26 ESA12207.1 - 3.7e-17 62.3 0.3 4.7e-17 61.9 0.2 1.1 1 0 0 1 1 1 1 BTB/POZ domain Far-17a_AIG1 PF04750.9 ESA12208.1 - 0.1 11.7 0.0 0.1 11.7 0.0 1.0 1 0 0 1 1 1 0 FAR-17a/AIG1-like protein LAG1-DNAbind PF09271.6 ESA12209.1 - 0.00017 22.0 0.1 0.00017 22.0 0.0 3.1 4 0 0 4 4 4 1 LAG1, DNA binding BAF1_ABF1 PF04684.8 ESA12209.1 - 0.023 13.5 31.5 0.041 12.7 6.3 3.0 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor SusE PF14292.1 ESA12210.1 - 0.049 13.4 0.3 0.049 13.4 0.2 1.1 1 0 0 1 1 1 0 SusE outer membrane protein RE_Bpu10I PF09549.5 ESA12210.1 - 0.054 13.0 0.2 0.057 12.9 0.1 1.0 1 0 0 1 1 1 0 Bpu10I restriction endonuclease AOX PF01786.12 ESA12210.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Alternative oxidase Myb_DNA-binding PF00249.26 ESA12211.1 - 2.1e-05 24.5 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain HgmA PF04209.8 ESA12211.1 - 0.00033 19.1 0.0 0.00037 18.9 0.0 1.1 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Myb_DNA-bind_6 PF13921.1 ESA12211.1 - 0.00096 19.2 0.6 0.00096 19.2 0.4 2.1 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA12211.1 - 0.43 11.2 4.1 12 6.5 0.2 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain LMP PF04778.7 ESA12211.1 - 1.7 8.3 6.4 2.1 8.1 0.6 2.0 2 0 0 2 2 2 0 LMP repeated region RasGEF PF00617.14 ESA12213.1 - 4.8e-68 228.6 1.2 1.4e-67 227.0 0.8 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESA12213.1 - 9e-29 99.6 0.2 5e-28 97.2 0.2 2.4 1 0 0 1 1 1 1 RasGEF N-terminal motif WW PF00397.21 ESA12213.1 - 2.1e-10 40.2 14.4 1.7e-07 30.9 1.9 2.8 2 0 0 2 2 2 2 WW domain UPF0086 PF01868.11 ESA12215.1 - 9e-24 82.9 0.1 1.2e-22 79.3 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function UPF0086 Clat_adaptor_s PF01217.15 ESA12216.1 - 4.1e-19 68.6 0.4 4.8e-19 68.4 0.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain vATP-synt_AC39 PF01992.11 ESA12217.1 - 1e-105 353.6 0.1 1.1e-105 353.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit SQS_PSY PF00494.14 ESA12217.1 - 0.098 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Squalene/phytoene synthase WD40 PF00400.27 ESA12218.1 - 8.1e-47 155.5 19.6 4.8e-08 32.5 0.3 8.5 8 1 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA12218.1 - 2.3e-15 55.7 2.0 1.2e-05 23.6 0.1 3.2 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA12218.1 - 9.3e-07 27.9 11.8 0.0089 14.8 0.9 4.9 3 2 2 5 5 5 4 Nup133 N terminal like F-box PF00646.28 ESA12218.1 - 0.00021 20.8 0.4 0.00059 19.4 0.3 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA12218.1 - 0.00051 19.7 0.9 0.0013 18.4 0.3 2.0 2 0 0 2 2 2 1 F-box-like BBS2_Mid PF14783.1 ESA12218.1 - 0.019 14.7 0.1 3 7.6 0.0 3.5 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Sel1 PF08238.7 ESA12219.1 - 5.2e-77 252.6 29.6 1.4e-11 44.6 0.0 7.0 7 0 0 7 7 7 7 Sel1 repeat TPR_17 PF13431.1 ESA12219.1 - 7.4e-08 32.0 10.5 0.89 9.9 0.0 7.1 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA12219.1 - 0.00014 22.1 17.3 0.41 11.2 0.1 6.6 7 1 0 7 7 7 2 Tetratricopeptide repeat Glu_syn_central PF04898.9 ESA12219.1 - 0.0011 18.3 5.1 10 5.2 0.1 4.9 2 2 3 5 5 5 1 Glutamate synthase central domain MIT PF04212.13 ESA12219.1 - 0.0095 15.8 36.1 1.8 8.4 0.2 6.9 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA12219.1 - 0.021 14.5 4.8 29 4.4 0.0 5.4 7 0 0 7 7 7 0 Lung surfactant protein D coiled-coil trimerisation DUF424 PF04242.8 ESA12219.1 - 0.024 14.6 1.8 17 5.5 0.1 4.5 1 1 3 4 4 4 0 Protein of unknown function (DUF424) BAR_3_WASP_bdg PF10456.4 ESA12219.1 - 0.3 10.2 5.6 21 4.2 0.1 4.2 1 1 3 5 5 5 0 WASP-binding domain of Sorting nexin protein DUF2761 PF10959.3 ESA12219.1 - 3.6 7.2 15.4 19 4.9 0.0 5.4 1 1 5 6 6 6 0 Protein of unknown function (DUF2761) STE PF02200.11 ESA12219.1 - 4 7.6 6.0 96 3.1 0.0 4.5 3 2 2 5 5 5 0 STE like transcription factor UPF0175 PF03683.8 ESA12219.1 - 4.3 6.8 6.8 41 3.7 0.0 4.2 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0175) Foie-gras_1 PF11817.3 ESA12219.1 - 5.4 6.4 15.2 1.5e+04 -7.3 10.6 4.9 1 1 0 1 1 0 0 Foie gras liver health family 1 KilA-N PF04383.8 ESA12221.1 - 0.00011 21.8 0.0 0.0041 16.7 0.0 2.0 1 1 0 1 1 1 1 KilA-N domain PH_2 PF08458.5 ESA12221.1 - 0.13 12.1 0.3 0.14 12.1 0.2 1.1 1 0 0 1 1 1 0 Plant pleckstrin homology-like region BRX_N PF13713.1 ESA12223.1 - 0.0029 17.0 0.3 0.8 9.2 0.1 2.7 2 0 0 2 2 2 1 Transcription factor BRX N-terminal domain LOH1CR12 PF10158.4 ESA12223.1 - 0.18 11.5 7.6 0.27 11.0 4.5 1.9 1 1 0 1 1 1 0 Tumour suppressor protein CENP-Q PF13094.1 ESA12223.1 - 0.37 10.7 22.7 0.17 11.9 8.4 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Cep57_CLD_2 PF14197.1 ESA12223.1 - 0.75 9.7 21.4 1.5 8.7 0.1 4.3 2 2 2 4 4 4 0 Centrosome localisation domain of PPC89 UPF0242 PF06785.6 ESA12223.1 - 0.86 8.2 17.7 1.1 7.8 12.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF4407 PF14362.1 ESA12223.1 - 1.1 8.1 13.1 1.6 7.5 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.7 ESA12223.1 - 1.1 9.0 19.7 0.025 14.3 6.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Phage_GP20 PF06810.6 ESA12223.1 - 1.4 8.2 38.4 0.2 11.1 7.7 3.3 1 1 2 3 3 3 0 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.7 ESA12223.1 - 6.5 6.5 28.5 5.7 6.6 6.5 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1515 PF07439.6 ESA12223.1 - 6.6 6.5 7.6 3 7.6 1.5 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1515) Acetyltransf_1 PF00583.19 ESA12224.1 - 2.2e-11 43.6 0.0 3.1e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA12224.1 - 1.1e-08 35.0 0.1 1.6e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA12224.1 - 0.005 17.0 0.0 0.0066 16.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA12224.1 - 0.099 12.4 0.0 0.27 10.9 0.0 1.8 1 1 0 1 1 1 0 FR47-like protein NmrA PF05368.8 ESA12225.1 - 4.9e-53 179.7 0.0 5.4e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA12225.1 - 2.3e-13 50.5 0.0 3.3e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA12225.1 - 8.2e-08 31.2 0.0 1.6e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 ESA12225.1 - 1.3e-05 24.8 0.0 4.9e-05 22.8 0.0 2.0 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 ESA12225.1 - 0.00027 20.8 0.0 0.00045 20.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA12225.1 - 0.00029 20.5 0.0 0.00044 19.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 ESA12225.1 - 0.0056 15.6 0.1 0.0088 15.0 0.1 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase TrkA_N PF02254.13 ESA12225.1 - 0.0068 16.3 0.0 0.016 15.1 0.0 1.7 1 1 0 1 1 1 1 TrkA-N domain ydhR PF08803.6 ESA12225.1 - 0.024 14.6 0.4 0.28 11.2 0.0 2.2 2 0 0 2 2 2 0 Putative mono-oxygenase ydhR DapB_N PF01113.15 ESA12225.1 - 0.086 12.7 0.1 0.2 11.6 0.1 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 ESA12225.1 - 0.14 11.0 0.0 0.72 8.7 0.0 2.0 3 0 0 3 3 3 0 Male sterility protein Pkinase PF00069.20 ESA12228.1 - 3.2e-51 173.9 1.6 3.9e-51 173.7 1.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12228.1 - 4.7e-51 173.3 0.1 5.6e-51 173.1 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA12228.1 - 0.00016 20.8 0.1 0.00029 19.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA12228.1 - 0.00097 18.1 0.0 0.0015 17.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA12228.1 - 0.0013 18.0 0.3 0.0013 18.0 0.2 1.6 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA12228.1 - 0.0015 17.8 0.2 0.0032 16.8 0.1 1.5 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA12228.1 - 0.034 13.8 0.1 0.13 11.9 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Spore_YunB PF09560.5 ESA12230.1 - 0.024 14.3 0.1 5.2 6.8 0.0 2.4 1 1 1 2 2 2 0 Sporulation protein YunB (Spo_YunB) DUF3284 PF11687.3 ESA12230.1 - 0.034 13.8 0.3 0.064 12.9 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3284) DUF960 PF06124.6 ESA12230.1 - 0.41 10.9 3.8 7 6.9 0.5 2.4 1 1 2 3 3 3 0 Staphylococcal protein of unknown function (DUF960) SR-25 PF10500.4 ESA12231.1 - 0.38 10.1 5.2 0.41 10.0 3.6 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Asp_protease_2 PF13650.1 ESA12232.1 - 5.1e-05 23.6 0.1 8.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Aldedh PF00171.17 ESA12233.1 - 0.041 12.2 0.0 0.041 12.2 0.0 1.0 1 0 0 1 1 1 0 Aldehyde dehydrogenase family CTD_bind PF04818.8 ESA12235.1 - 1.5e-06 28.3 0.0 6.6e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.3 ESA12235.1 - 0.00061 19.8 1.0 0.00061 19.8 0.7 2.6 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 DASH_Ask1 PF08655.5 ESA12236.1 - 4e-21 74.5 0.5 7.7e-21 73.6 0.3 1.5 1 0 0 1 1 1 1 DASH complex subunit Ask1 HTH_43 PF09904.4 ESA12236.1 - 0.073 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix DUF2737 PF10930.3 ESA12238.1 - 0.05 13.2 3.0 0.3 10.7 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2737) Sel1 PF08238.7 ESA12240.1 - 3.2e-68 224.6 41.9 2.6e-12 46.9 0.2 8.7 9 1 0 9 9 9 7 Sel1 repeat HTH_16 PF12645.2 ESA12240.1 - 0.00035 20.4 3.4 11 5.9 0.0 4.8 6 0 0 6 6 5 0 Helix-turn-helix domain TPR_6 PF13174.1 ESA12240.1 - 0.0011 19.3 18.0 0.25 11.8 0.1 5.9 7 0 0 7 7 6 2 Tetratricopeptide repeat MIT PF04212.13 ESA12240.1 - 0.0016 18.2 17.8 0.022 14.6 0.6 5.3 4 2 1 5 5 5 2 MIT (microtubule interacting and transport) domain Peptidase_C14 PF00656.17 ESA12240.1 - 0.0033 17.1 0.1 31 4.1 0.0 4.4 1 1 2 4 4 4 0 Caspase domain DUF2758 PF10957.3 ESA12240.1 - 0.042 13.6 5.3 9.9 6.0 0.1 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF2758) DUF1389 PF07146.6 ESA12240.1 - 0.045 12.7 2.9 9 5.2 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1389) Ank_2 PF12796.2 ESA12240.1 - 0.078 13.3 4.5 3.6 7.9 2.6 3.3 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) DUF3881 PF12997.2 ESA12240.1 - 0.11 11.5 1.9 15 4.4 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function, E. rectale Gene description (DUF3881) Pedibin PF08182.6 ESA12240.1 - 0.11 12.0 1.8 55 3.3 0.0 3.9 4 0 0 4 4 4 0 Pedibin/Hym-346 family TPR_12 PF13424.1 ESA12240.1 - 0.11 12.4 20.4 0.32 10.9 0.2 5.5 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12240.1 - 0.44 10.8 0.1 0.44 10.8 0.0 7.8 8 2 1 9 9 9 0 Tetratricopeptide repeat CG-1 PF03859.11 ESA12240.1 - 0.69 9.4 11.6 10 5.6 0.7 5.3 1 1 4 5 5 5 0 CG-1 domain TOM20_plant PF06552.7 ESA12240.1 - 3.5 7.1 12.4 2.3 7.7 0.2 4.7 2 2 5 7 7 7 0 Plant specific mitochondrial import receptor subunit TOM20 Sel1 PF08238.7 ESA12241.1 - 8.6e-63 207.4 37.4 5.2e-14 52.3 0.7 6.6 7 0 0 7 7 7 5 Sel1 repeat TPR_17 PF13431.1 ESA12241.1 - 1.5e-07 31.0 20.1 1.6 9.0 0.0 6.8 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.1 ESA12241.1 - 4.3e-07 29.9 16.4 0.97 10.0 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA12241.1 - 0.00033 20.2 30.6 0.5 10.0 0.5 4.8 1 1 4 5 5 5 4 TPR repeat TPR_12 PF13424.1 ESA12241.1 - 0.0025 17.6 19.6 0.08 12.8 2.7 4.8 1 1 3 4 4 4 2 Tetratricopeptide repeat NUMOD1 PF07453.8 ESA12241.1 - 0.02 14.7 1.5 33 4.5 0.0 4.3 4 0 0 4 4 4 0 NUMOD1 domain Ph1570 PF09638.5 ESA12241.1 - 0.045 13.5 5.9 11 5.8 0.1 4.2 1 1 2 4 4 4 0 Ph1570 protein DUF3674 PF12426.3 ESA12241.1 - 0.083 12.3 9.7 14 5.2 0.0 4.8 5 0 0 5 5 5 0 RNA dependent RNA polymerase DIL PF01843.14 ESA12241.1 - 0.19 11.6 2.0 2.4 8.0 0.1 2.9 2 1 2 4 4 4 0 DIL domain DUF3558 PF12079.3 ESA12241.1 - 0.24 11.0 0.8 23 4.5 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3558) Surfac_D-trimer PF09006.6 ESA12241.1 - 0.73 9.6 4.9 29 4.4 0.0 3.9 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation PixA PF12306.3 ESA12241.1 - 1.1 9.1 5.5 8.7 6.1 0.8 3.1 1 1 2 3 3 3 0 Inclusion body protein zf-GRF PF06839.7 ESA12241.1 - 1.2 9.1 13.8 3.1 7.7 0.4 3.9 4 0 0 4 4 4 0 GRF zinc finger Apc3 PF12895.2 ESA12241.1 - 1.7 8.8 28.8 1.2 9.3 2.2 4.7 1 1 4 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Rapamycin_bind PF08771.6 ESA12241.1 - 2.8 8.0 12.6 17 5.6 0.1 4.4 2 1 2 4 4 4 0 Rapamycin binding domain DUF3830 PF12903.2 ESA12241.1 - 7.2 5.9 8.0 17 4.7 0.3 3.2 2 2 0 3 3 3 0 Protein of unknown function (DUF3830) TPR_10 PF13374.1 ESA12241.1 - 8.2 6.5 17.6 2.9 7.9 0.7 5.9 6 1 0 6 6 6 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA12245.1 - 8.1e-05 22.2 0.1 0.00021 20.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA12245.1 - 0.28 10.8 0.0 0.28 10.8 0.0 3.4 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Pkinase PF00069.20 ESA12246.1 - 3.1e-09 36.3 0.0 3.5e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12246.1 - 8.4e-08 31.5 0.0 9.5e-08 31.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ESA12246.1 - 0.0068 16.3 0.0 0.55 10.2 0.0 2.1 1 1 1 2 2 2 1 ABC1 family DUF1743 PF08489.6 ESA12246.1 - 0.0076 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) FTA2 PF13095.1 ESA12246.1 - 0.012 15.2 0.3 0.012 15.1 0.2 1.0 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF3232 PF11554.3 ESA12246.1 - 0.02 14.8 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) Pkinase_Tyr PF07714.12 ESA12247.1 - 1.1e-33 116.4 0.0 1.6e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12247.1 - 3.3e-31 108.4 0.0 4.8e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA12247.1 - 7.5e-05 21.8 0.0 0.00016 20.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA12247.1 - 0.0041 16.8 0.0 2.5 7.7 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 ESA12247.1 - 0.0044 16.3 0.0 0.0088 15.4 0.0 1.6 1 0 0 1 1 1 1 RIO1 family PBP1_TM PF14812.1 ESA12248.1 - 0.0069 16.6 3.2 0.036 14.3 0.3 2.1 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2031 PF09592.5 ESA12248.1 - 0.28 10.3 6.4 0.31 10.1 4.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) SRC-1 PF08832.5 ESA12248.1 - 0.31 11.8 6.2 1.2 9.8 1.6 2.4 1 1 1 2 2 2 0 Steroid receptor coactivator Ly49 PF08391.5 ESA12249.1 - 0.13 12.4 1.4 0.56 10.3 0.1 2.1 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Minor_capsid_2 PF11114.3 ESA12251.1 - 0.0093 15.8 0.6 0.025 14.4 0.4 1.7 1 0 0 1 1 1 1 Minor capsid protein SPRY PF00622.23 ESA12252.1 - 5.8e-16 58.6 0.7 6.8e-16 58.4 0.5 1.1 1 0 0 1 1 1 1 SPRY domain SPRY PF00622.23 ESA12253.1 - 1.1e-17 64.2 1.3 1.3e-17 64.0 0.9 1.0 1 0 0 1 1 1 1 SPRY domain DUF2985 PF11204.3 ESA12254.1 - 0.43 10.3 3.4 1.7 8.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) SPRY PF00622.23 ESA12255.1 - 1.6e-11 44.3 0.1 1.8e-11 44.2 0.1 1.0 1 0 0 1 1 1 1 SPRY domain Ribosomal_S17 PF00366.15 ESA12258.1 - 0.011 15.7 1.4 0.014 15.4 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein S17 HupF_HypC PF01455.13 ESA12258.1 - 0.012 15.5 0.0 0.083 12.8 0.0 2.0 2 0 0 2 2 2 0 HupF/HypC family E1_DerP2_DerF2 PF02221.10 ESA12260.1 - 6.9e-07 29.5 0.0 9.5e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ML domain SAF PF08666.7 ESA12260.1 - 0.12 12.7 0.5 0.65 10.4 0.3 2.1 1 1 2 3 3 3 0 SAF domain AAA_12 PF13087.1 ESA12261.1 - 2.1e-08 33.7 4.4 2.3e-05 23.8 0.0 3.1 2 2 1 3 3 3 2 AAA domain AAA_11 PF13086.1 ESA12261.1 - 0.01 15.4 8.6 0.015 14.8 4.3 2.3 2 1 0 2 2 2 0 AAA domain DUF4050 PF13259.1 ESA12261.1 - 0.018 14.9 0.7 0.033 14.1 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) DUF4558 PF15104.1 ESA12261.1 - 0.14 12.1 4.1 0.065 13.1 1.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4558) UvrD-helicase PF00580.16 ESA12261.1 - 0.72 9.0 10.1 3.3 6.9 7.0 1.9 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_12 PF13087.1 ESA12262.1 - 3.4e-18 65.7 0.1 4.3e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA12262.1 - 0.014 14.9 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain INCENP_ARK-bind PF03941.10 ESA12263.1 - 3.8e-15 55.4 0.1 6.1e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region PS_Dcarbxylase PF02666.10 ESA12264.1 - 1.3e-53 181.3 0.0 4.5e-53 179.5 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase C2 PF00168.25 ESA12264.1 - 1.5e-39 133.7 1.1 7.4e-20 70.5 0.0 2.8 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.1 ESA12264.1 - 0.0023 18.0 0.0 0.006 16.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair zf-CCHC PF00098.18 ESA12266.1 - 0.0034 17.2 6.4 0.0034 17.2 4.4 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.1 ESA12266.1 - 0.066 12.9 2.1 0.12 12.1 1.5 1.5 1 0 0 1 1 1 0 Zinc knuckle IBR PF01485.16 ESA12266.1 - 0.29 11.0 5.6 0.72 9.7 3.9 1.8 1 1 0 1 1 1 0 IBR domain Sel1 PF08238.7 ESA12267.1 - 3.5e-27 94.2 11.6 3.2e-11 43.4 0.6 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_12 PF13424.1 ESA12267.1 - 0.0036 17.1 4.8 0.27 11.1 0.8 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat MIT PF04212.13 ESA12267.1 - 0.0097 15.7 6.0 0.59 10.0 0.2 3.8 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 ESA12267.1 - 0.013 15.4 5.7 0.13 12.2 0.0 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12267.1 - 0.017 15.2 6.1 2.7 8.3 0.2 4.0 3 2 0 3 3 3 0 Tetratricopeptide repeat Colicin_immun PF09204.5 ESA12267.1 - 0.041 13.9 0.4 0.66 10.0 0.3 2.6 1 1 0 1 1 1 0 Bacterial self-protective colicin-like immunity Plasmid_stabil PF05016.9 ESA12267.1 - 0.077 13.4 0.1 1.3 9.4 0.0 2.2 1 1 1 2 2 2 0 Plasmid stabilisation system protein TPR_6 PF13174.1 ESA12267.1 - 0.14 12.6 3.4 0.38 11.2 0.1 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 ESA12267.1 - 0.17 10.7 1.6 0.38 9.5 1.1 1.6 1 1 0 1 1 1 0 Spatacsin C-terminus Ph1570 PF09638.5 ESA12267.1 - 0.27 10.9 3.2 1.1 9.0 0.1 2.5 1 1 2 3 3 3 0 Ph1570 protein Apc3 PF12895.2 ESA12267.1 - 0.5 10.5 2.9 1.2 9.3 0.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 P63C PF10546.4 ESA12267.1 - 0.54 10.2 3.2 1.7 8.6 0.5 2.1 2 0 0 2 2 2 0 P63C domain TPR_2 PF07719.12 ESA12267.1 - 1.4 9.0 15.7 29 4.9 0.0 5.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA12267.1 - 1.5 8.5 9.8 2.5 7.8 3.0 2.6 2 1 0 2 2 2 0 TPR repeat DUF3674 PF12426.3 ESA12267.1 - 4.6 6.7 5.8 17 4.9 0.0 3.0 3 0 0 3 3 3 0 RNA dependent RNA polymerase Lipase_3 PF01764.20 ESA12268.1 - 4.7e-30 104.0 0.0 6.8e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Collagen PF01391.13 ESA12268.1 - 0.42 10.2 4.4 2.4 7.7 3.0 2.0 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Ribosomal_S27e PF01667.12 ESA12270.1 - 4.7e-27 93.2 2.5 4.7e-27 93.2 1.7 1.4 2 0 0 2 2 2 1 Ribosomal protein S27 IBR PF01485.16 ESA12270.1 - 0.0068 16.2 0.9 0.0068 16.2 0.6 1.4 1 1 0 1 1 1 1 IBR domain TF_Zn_Ribbon PF08271.7 ESA12270.1 - 0.071 12.4 2.5 0.13 11.5 1.7 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding PhnA_Zn_Ribbon PF08274.7 ESA12270.1 - 0.089 12.5 1.9 0.26 11.1 0.2 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon DUF3795 PF12675.2 ESA12270.1 - 0.33 11.1 2.5 4.5 7.5 1.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) Mu-like_Com PF10122.4 ESA12270.1 - 0.67 9.0 2.7 10 5.2 0.1 2.3 1 1 1 2 2 2 0 Mu-like prophage protein Com Zn_Tnp_IS1 PF03811.8 ESA12270.1 - 0.94 9.0 3.9 1.6 8.2 1.5 2.3 2 1 0 2 2 2 0 InsA N-terminal domain zf-C2HC5 PF06221.8 ESA12270.1 - 1.1 9.0 4.3 2.3 8.0 1.2 2.2 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type SR-25 PF10500.4 ESA12271.1 - 0.00016 21.2 6.3 0.00022 20.8 4.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Med3 PF11593.3 ESA12271.1 - 0.003 16.8 14.4 0.0032 16.7 10.0 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal DUF4614 PF15391.1 ESA12271.1 - 0.091 12.5 13.8 0.15 11.8 9.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Alg14 PF08660.6 ESA12271.1 - 0.11 12.5 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like Suf PF05843.9 ESA12271.1 - 0.54 9.9 11.0 0.66 9.6 7.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med13_C PF06333.7 ESA12271.1 - 0.68 8.4 9.9 0.75 8.2 6.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal Viral_Beta_CD PF04530.7 ESA12271.1 - 0.75 9.9 5.3 4.1 7.6 3.5 2.2 1 1 0 1 1 1 0 Viral Beta C/D like family Dicty_REP PF05086.7 ESA12271.1 - 1.1 6.9 11.5 1.1 6.8 8.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1675 PF07897.6 ESA12271.1 - 4.3 7.1 10.4 5.1 6.8 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FAM60A PF15396.1 ESA12271.1 - 6.5 6.4 9.0 9.3 5.9 6.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A HgmA PF04209.8 ESA12272.1 - 5.7e-196 650.9 0.2 6.4e-196 650.7 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase S10_plectin PF03501.10 ESA12273.1 - 0.00054 19.7 0.1 0.0012 18.6 0.1 1.5 1 0 0 1 1 1 1 Plectin/S10 domain ubiquitin PF00240.18 ESA12273.1 - 0.0014 17.9 0.0 0.029 13.7 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Mito_fiss_reg PF05308.6 ESA12273.1 - 8.5 5.6 9.4 15 4.8 6.5 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Metallophos_2 PF12850.2 ESA12274.1 - 1.5e-11 44.3 0.1 2.2e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 ESA12274.1 - 2.1e-10 40.3 6.1 2.9e-10 39.8 4.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ETF PF01012.16 ESA12275.1 - 3.5e-38 130.8 0.3 6.3e-38 130.0 0.2 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.14 ESA12275.1 - 1e-33 114.7 0.4 1.9e-33 113.9 0.3 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Virul_Fac PF10139.4 ESA12275.1 - 0.15 9.9 0.0 0.21 9.5 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor DUF3414 PF11894.3 ESA12276.1 - 4.1e-05 20.7 0.1 4.1e-05 20.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) DUF3414 PF11894.3 ESA12277.1 - 2.7e-215 717.5 34.5 4.3e-215 716.8 23.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) IglC PF11550.3 ESA12277.1 - 0.051 12.8 0.0 1 8.6 0.0 2.3 1 1 1 2 2 2 0 Intracellular growth locus C protein ResIII PF04851.10 ESA12280.1 - 0.043 13.6 0.4 0.048 13.4 0.2 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit HTH_29 PF13551.1 ESA12281.1 - 0.018 15.1 0.3 0.13 12.3 0.0 2.0 1 1 0 2 2 2 0 Winged helix-turn helix Lipase_3 PF01764.20 ESA12283.1 - 1.5e-32 112.1 0.0 2.4e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESA12283.1 - 0.1 11.9 0.0 12 5.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.2 ESA12283.1 - 0.15 11.8 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family RdRP PF05183.7 ESA12284.1 - 3.7e-189 630.1 2.5 5e-189 629.7 1.7 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase F-box-like PF12937.2 ESA12285.1 - 5.8e-05 22.7 4.2 0.00015 21.3 2.9 1.7 1 0 0 1 1 1 1 F-box-like DUF3988 PF13149.1 ESA12285.1 - 0.16 11.4 0.3 0.23 10.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3988) DUF659 PF04937.10 ESA12286.1 - 0.0019 17.6 0.1 0.069 12.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF 659) Poxvirus PF06227.7 ESA12286.1 - 0.0098 15.4 0.8 0.017 14.6 0.5 1.3 1 0 0 1 1 1 1 dsDNA Poxvirus PLC-beta_C PF08703.5 ESA12286.1 - 0.027 14.2 0.1 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 PLC-beta C terminal FlaC_arch PF05377.6 ESA12286.1 - 0.11 12.4 1.1 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ATP-synt_S1 PF05827.7 ESA12292.1 - 0.0095 15.2 0.5 0.34 10.1 0.1 2.1 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Polysacc_synt_3 PF13440.1 ESA12292.1 - 0.01 15.3 0.3 0.013 14.9 0.2 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein E1-E2_ATPase PF00122.15 ESA12292.1 - 0.019 14.0 0.4 0.025 13.6 0.3 1.2 1 0 0 1 1 1 0 E1-E2 ATPase DUF3112 PF11309.3 ESA12292.1 - 0.024 14.4 1.6 0.037 13.8 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) MpPF26 PF07666.6 ESA12292.1 - 0.06 13.2 2.9 0.09 12.6 2.0 1.3 1 0 0 1 1 1 0 M penetrans paralogue family 26 DUF4010 PF13194.1 ESA12292.1 - 0.063 12.5 2.1 0.13 11.5 1.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4010) NMN_transporter PF04973.7 ESA12292.1 - 0.063 12.7 0.7 0.1 12.0 0.5 1.3 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter TMEM154 PF15102.1 ESA12292.1 - 0.16 11.6 0.6 0.23 11.1 0.4 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF3357 PF11837.3 ESA12292.1 - 6.1 6.7 6.3 30 4.5 1.1 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF3357) DUF4014 PF13198.1 ESA12292.1 - 8.7 6.8 9.1 12 6.3 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4014) BCS1_N PF08740.6 ESA12293.1 - 3.1e-05 23.6 0.1 0.12 11.9 0.0 3.0 3 0 0 3 3 3 2 BCS1 N terminal DUF187 PF02638.10 ESA12293.1 - 5.6e-05 22.1 3.2 0.0062 15.4 0.0 2.7 3 0 0 3 3 3 2 Glycosyl hydrolase like GH101 PA14_2 PF10528.4 ESA12293.1 - 0.01 15.7 5.3 5.4 7.0 0.1 3.8 3 1 1 4 4 4 0 GLEYA domain Phage-A118_gp45 PF10653.4 ESA12293.1 - 0.012 15.4 0.1 26 4.7 0.0 3.4 3 0 0 3 3 3 0 Protein gp45 of Bacteriophage A118 Prp18 PF02840.10 ESA12293.1 - 0.012 15.3 0.0 0.72 9.6 0.0 2.5 3 0 0 3 3 3 0 Prp18 domain DUF3991 PF13154.1 ESA12293.1 - 0.047 13.8 1.4 2.4 8.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3991) DUF4339 PF14237.1 ESA12293.1 - 0.062 12.8 0.0 37 4.0 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4339) SF3a60_bindingd PF12108.3 ESA12293.1 - 0.077 12.5 7.0 19 4.9 0.1 4.0 4 0 0 4 4 4 0 Splicing factor SF3a60 binding domain SpoU_methylas_C PF12105.3 ESA12293.1 - 0.098 12.2 0.0 20 4.8 0.0 2.9 3 0 0 3 3 3 0 SpoU, rRNA methylase, C-terminal DUF190 PF02641.10 ESA12293.1 - 0.14 12.0 0.6 86 3.0 0.0 3.8 3 2 0 3 3 3 0 Uncharacterized ACR, COG1993 Ins_allergen_rp PF06757.8 ESA12293.1 - 0.15 11.4 2.0 9.4 5.6 0.0 3.1 3 1 0 3 3 3 0 Insect allergen related repeat, nitrile-specifier detoxification Mur_ligase_M PF08245.7 ESA12294.1 - 0.043 13.8 4.0 0.057 13.4 2.2 1.6 1 1 0 1 1 1 0 Mur ligase middle domain ECM11 PF15463.1 ESA12294.1 - 0.063 13.5 0.2 0.063 13.5 0.1 2.1 2 0 0 2 2 2 0 Extracellular mutant protein 11 Med28 PF11594.3 ESA12297.1 - 0.0059 16.8 5.0 0.0091 16.2 3.4 1.4 1 0 0 1 1 1 1 Mediator complex subunit 28 Herpes_BLRF2 PF05812.7 ESA12297.1 - 0.0062 16.3 4.0 0.0062 16.3 2.8 1.8 2 0 0 2 2 2 1 Herpesvirus BLRF2 protein DUF4407 PF14362.1 ESA12297.1 - 0.05 12.5 2.5 0.087 11.7 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF342 PF03961.8 ESA12297.1 - 0.15 10.4 8.3 0.16 10.3 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3510 PF12022.3 ESA12297.1 - 0.5 10.4 9.8 5 7.2 1.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) Peptidase_U57 PF05582.7 ESA12297.1 - 0.67 8.8 7.2 1 8.2 5.0 1.2 1 0 0 1 1 1 0 YabG peptidase U57 PolyA_pol PF01743.15 ESA12297.1 - 1.9 8.6 9.4 3.7 7.7 2.7 2.1 1 1 1 2 2 2 0 Poly A polymerase head domain Cep57_CLD_2 PF14197.1 ESA12297.1 - 1.9 8.4 11.3 2.6 8.0 0.3 2.4 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF972 PF06156.8 ESA12297.1 - 2.5 8.5 10.4 0.33 11.3 2.5 2.4 1 1 1 3 3 3 0 Protein of unknown function (DUF972) Phlebovirus_NSM PF07246.6 ESA12297.1 - 8 5.5 11.9 12 4.9 8.1 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Pkinase PF00069.20 ESA12298.1 - 1.4e-18 66.9 0.2 1.6e-18 66.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12298.1 - 2.9e-17 62.5 0.0 3.2e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA12298.1 - 1.6e-05 24.7 0.0 1.6e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA12298.1 - 0.00026 20.2 0.0 0.00032 20.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA12298.1 - 0.0004 19.7 0.0 0.00042 19.7 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA12298.1 - 0.0029 16.6 0.0 0.003 16.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA12298.1 - 0.0065 16.0 0.2 0.035 13.6 0.1 1.8 1 1 1 2 2 2 2 Choline/ethanolamine kinase zf-C3HC4_2 PF13923.1 ESA12300.1 - 0.0013 18.6 2.8 0.0035 17.3 2.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA12300.1 - 0.016 14.8 3.4 0.026 14.1 2.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA12300.1 - 0.018 14.7 2.0 0.042 13.5 1.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.1 ESA12300.1 - 0.04 13.7 4.3 0.17 11.7 3.1 1.9 1 1 1 2 2 2 0 Ring finger domain zf-rbx1 PF12678.2 ESA12300.1 - 0.12 12.5 1.1 0.24 11.5 0.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_5 PF14634.1 ESA12300.1 - 0.43 10.3 6.3 0.8 9.4 4.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA12300.1 - 0.56 9.9 3.9 2.7 7.7 2.9 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FAR1 PF03101.10 ESA12302.1 - 1.3e-05 25.6 0.4 2.5e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain SoxY PF13501.1 ESA12303.1 - 0.011 15.7 0.0 0.29 11.1 0.0 2.3 2 0 0 2 2 2 0 Sulfur oxidation protein SoxY Brix PF04427.13 ESA12305.1 - 2.8e-55 186.9 1.9 3.9e-55 186.4 1.3 1.2 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.5 ESA12305.1 - 0.00032 19.8 32.7 0.00055 19.1 22.7 1.4 1 0 0 1 1 1 1 BUD22 Daxx PF03344.10 ESA12305.1 - 0.89 7.9 44.7 1.4 7.3 31.0 1.2 1 0 0 1 1 1 0 Daxx Family CENP-T PF15511.1 ESA12305.1 - 9.7 5.3 30.8 15 4.7 21.3 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T DUF3510 PF12022.3 ESA12309.1 - 0.082 13.0 10.6 0.21 11.6 1.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) V_ATPase_I PF01496.14 ESA12309.1 - 0.16 9.8 9.6 0.19 9.5 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Allexi_40kDa PF05549.6 ESA12309.1 - 0.17 11.1 4.4 0.23 10.7 3.0 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Sec20 PF03908.8 ESA12309.1 - 0.2 11.3 2.4 0.36 10.5 1.7 1.4 1 0 0 1 1 1 0 Sec20 DUF4446 PF14584.1 ESA12309.1 - 0.38 10.5 6.9 0.6 9.9 4.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) TerB-C PF15615.1 ESA12309.1 - 0.69 10.1 9.3 2.1 8.5 0.0 2.2 1 1 0 2 2 2 0 TerB-C domain Mnd1 PF03962.10 ESA12309.1 - 1.6 8.3 17.9 1.2 8.7 4.3 2.2 1 1 1 2 2 2 0 Mnd1 family DUF3987 PF13148.1 ESA12309.1 - 2.5 6.6 7.8 3.9 5.9 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF972 PF06156.8 ESA12309.1 - 2.9 8.2 13.5 0.78 10.1 3.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ING PF12998.2 ESA12309.1 - 7.4 6.9 13.3 6.3 7.1 7.6 2.2 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding ApoLp-III PF07464.6 ESA12312.1 - 0.0095 15.9 6.9 0.029 14.3 4.8 2.0 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) DUF3510 PF12022.3 ESA12312.1 - 0.23 11.5 8.7 0.63 10.1 0.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) DUF4446 PF14584.1 ESA12312.1 - 0.27 11.0 6.3 0.26 11.0 2.7 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) V_ATPase_I PF01496.14 ESA12312.1 - 0.28 8.9 8.7 0.29 8.9 6.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EssA PF10661.4 ESA12312.1 - 0.35 10.5 9.7 0.16 11.6 4.8 1.8 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA YgaB PF14182.1 ESA12312.1 - 0.91 9.8 8.6 1.3 9.2 3.5 2.3 2 0 0 2 2 2 0 YgaB-like protein DUF1640 PF07798.6 ESA12312.1 - 1.1 9.3 12.7 2.3 8.2 8.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) YlqD PF11068.3 ESA12312.1 - 1.3 9.0 10.8 0.3 11.1 4.7 1.9 1 1 1 2 2 2 0 YlqD protein DivIVA PF05103.8 ESA12312.1 - 2.8 7.9 11.2 0.71 9.9 4.9 2.0 1 1 1 2 2 2 0 DivIVA protein DUF3552 PF12072.3 ESA12312.1 - 4.7 6.3 16.9 0.68 9.1 7.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) DUF972 PF06156.8 ESA12312.1 - 6.1 7.2 10.7 1.7 8.9 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) UPF0242 PF06785.6 ESA12312.1 - 8.7 4.8 9.8 4.5 5.8 4.6 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) Dimer_Tnp_hAT PF05699.9 ESA12314.1 - 1.2e-19 69.6 0.2 1.3e-19 69.5 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region RE_TdeIII PF09520.5 ESA12315.1 - 0.025 13.8 2.5 1.3 8.2 0.0 2.4 1 1 0 2 2 2 0 Type II restriction endonuclease, TdeIII DUF3713 PF12506.3 ESA12315.1 - 0.17 11.9 8.1 2.5 8.1 1.8 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3713) Med21 PF11221.3 ESA12315.1 - 1.3 9.0 4.7 4.7 7.1 0.1 3.0 3 0 0 3 3 3 0 Subunit 21 of Mediator complex DUF2986 PF11661.3 ESA12316.1 - 0.001 19.3 0.1 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) SAD_SRA PF02182.12 ESA12316.1 - 0.086 12.1 0.2 0.12 11.6 0.1 1.3 1 1 0 1 1 1 0 SAD/SRA domain Sel1 PF08238.7 ESA12318.1 - 3.4e-58 192.7 23.4 3.5e-12 46.5 0.3 6.0 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA12318.1 - 3.2e-06 27.2 10.9 1.6 9.3 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat MgrB PF13998.1 ESA12318.1 - 0.0056 16.4 3.5 4.3 7.1 0.2 4.5 5 0 0 5 5 5 1 MgrB protein SinI PF08671.5 ESA12318.1 - 0.15 11.4 0.7 10 5.6 0.0 3.1 3 0 0 3 3 3 0 Anti-repressor SinI TPR_17 PF13431.1 ESA12318.1 - 1.1 9.5 14.4 61 4.1 1.2 6.9 3 2 3 6 6 6 0 Tetratricopeptide repeat Peptidase_S49_N PF08496.5 ESA12319.1 - 0.01 15.6 1.0 0.01 15.6 0.7 2.0 2 0 0 2 2 2 1 Peptidase family S49 N-terminal YABBY PF04690.8 ESA12321.1 - 1.4e-15 57.9 3.2 1.7e-15 57.7 2.2 1.0 1 0 0 1 1 1 1 YABBY protein DUF1014 PF06244.7 ESA12321.1 - 7.8e-10 39.0 7.1 1.1e-09 38.5 4.9 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) HMG_box PF00505.14 ESA12321.1 - 4.2e-09 36.5 2.0 7.2e-09 35.8 1.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12321.1 - 7.2e-07 29.4 1.7 8.9e-07 29.1 0.4 1.6 1 1 1 2 2 2 1 HMG-box domain tRNA_synt_1c_R2 PF04557.10 ESA12321.1 - 3.9 8.2 8.3 4.8 7.9 5.7 1.3 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 HVSL PF09749.4 ESA12322.1 - 9e-57 191.8 1.1 1.2e-56 191.4 0.8 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein Tbf5 PF06331.7 ESA12322.1 - 0.18 11.5 1.8 0.35 10.6 0.1 2.3 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 Abhydrolase_6 PF12697.2 ESA12324.1 - 3e-20 73.0 0.0 4.6e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA12324.1 - 4.4e-12 45.9 0.0 9.1e-12 44.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA12324.1 - 3.2e-08 33.4 0.0 2.4e-07 30.5 0.0 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF1057 PF06342.7 ESA12324.1 - 0.073 11.8 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF4618 PF15397.1 ESA12325.1 - 0.022 14.1 9.2 0.04 13.2 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Dynamin_N PF00350.18 ESA12325.1 - 0.061 13.1 0.2 0.061 13.1 0.1 1.8 2 0 0 2 2 2 0 Dynamin family Nup54 PF13874.1 ESA12325.1 - 0.098 12.3 3.4 0.25 10.9 2.4 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Dict-STAT-coil PF09267.5 ESA12326.1 - 0.021 15.0 0.7 0.023 14.8 0.5 1.1 1 0 0 1 1 1 0 Dictyostelium STAT, coiled coil EF-hand_6 PF13405.1 ESA12326.1 - 0.074 12.9 0.6 2 8.4 0.4 2.4 1 1 0 1 1 1 0 EF-hand domain Dimer_Tnp_hAT PF05699.9 ESA12327.1 - 3.9e-21 74.4 0.3 4.3e-21 74.3 0.2 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ESA12328.1 - 2.6e-19 69.3 0.0 4.5e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12328.1 - 1.2e-14 54.1 0.0 3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain LPP20 PF02169.11 ESA12328.1 - 0.18 11.9 1.3 0.44 10.6 0.0 2.3 2 0 0 2 2 2 0 LPP20 lipoprotein HATPase_c PF02518.21 ESA12330.1 - 0.00022 20.9 0.0 0.00045 19.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4325 PF14213.1 ESA12330.1 - 0.0088 15.6 1.1 0.033 13.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4325) HATPase_c_2 PF13581.1 ESA12330.1 - 0.026 14.3 0.0 0.085 12.6 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Pkinase_Tyr PF07714.12 ESA12334.1 - 8.6e-30 103.6 0.0 1e-29 103.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12334.1 - 3.7e-28 98.3 0.0 4.8e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA12334.1 - 0.0051 16.5 0.7 0.0087 15.8 0.3 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1950 PF09187.5 ESA12336.1 - 0.089 12.9 0.3 0.093 12.8 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function(DUF1950) NPHI_C PF08469.5 ESA12336.1 - 0.11 12.3 1.2 0.13 12.1 0.9 1.1 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal Pkinase_Tyr PF07714.12 ESA12339.1 - 2.5e-30 105.4 0.0 1.1e-28 100.0 0.0 2.7 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12339.1 - 1.7e-27 96.1 0.0 2.7e-26 92.2 0.0 2.6 2 1 1 3 3 3 1 Protein kinase domain APH PF01636.18 ESA12339.1 - 0.11 12.2 0.2 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAM_2 PF07647.12 ESA12340.1 - 0.17 11.7 1.2 4.7 7.1 0.1 2.7 3 1 1 4 4 4 0 SAM domain (Sterile alpha motif) TLD PF07534.11 ESA12341.1 - 8.7e-08 32.2 0.2 2.4e-07 30.8 0.1 1.6 2 0 0 2 2 2 1 TLD HMG_box PF00505.14 ESA12342.1 - 1.1e-10 41.6 0.2 1.5e-05 25.2 0.0 2.6 2 0 0 2 2 2 2 HMG (high mobility group) box DUF4373 PF14297.1 ESA12342.1 - 0.00034 20.8 0.1 0.039 14.2 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4373) HMG_box_2 PF09011.5 ESA12342.1 - 0.011 16.0 0.6 5.5 7.4 0.0 2.6 2 1 0 2 2 2 0 HMG-box domain DUF2118 PF09891.4 ESA12342.1 - 0.031 13.9 0.3 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) P22_AR_N PF10547.4 ESA12342.1 - 0.046 13.5 0.2 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 P22_AR N-terminal domain DUF668 PF05003.7 ESA12342.1 - 0.07 13.3 0.1 1.7 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF668) FimH_man-bind PF09160.5 ESA12342.1 - 0.094 12.5 1.3 9.1 6.1 0.0 2.8 3 0 0 3 3 3 0 FimH, mannose binding DUF2267 PF10025.4 ESA12342.1 - 0.13 12.3 0.0 1.4 9.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) DUF3437 PF11919.3 ESA12342.1 - 0.16 11.6 0.4 6.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Gp-FAR-1 PF05823.7 ESA12342.1 - 0.31 11.0 8.9 1.9 8.4 0.9 2.7 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ORC4_C PF14629.1 ESA12343.1 - 1.4e-28 99.7 0.2 1.9e-28 99.2 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus Sipho_Gp157 PF05565.6 ESA12343.1 - 0.052 13.1 5.8 0.22 11.1 0.9 2.3 2 0 0 2 2 2 0 Siphovirus Gp157 ThiI PF02568.9 ESA12343.1 - 0.15 11.5 0.8 1.7 8.0 0.1 2.7 3 0 0 3 3 3 0 Thiamine biosynthesis protein (ThiI) Agenet PF05641.7 ESA12344.1 - 0.0011 19.1 0.1 0.0086 16.1 0.0 2.4 2 1 0 2 2 2 1 Agenet domain Pentapeptide_4 PF13599.1 ESA12344.1 - 0.068 12.9 1.5 0.18 11.6 1.1 1.7 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Spc7 PF08317.6 ESA12345.1 - 6.3e-06 25.0 9.7 9.8e-06 24.4 6.5 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein DUF4206 PF13901.1 ESA12345.1 - 0.024 14.1 0.5 0.045 13.2 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Zein-binding PF04576.10 ESA12345.1 - 0.11 12.6 7.7 0.11 12.6 0.5 2.4 2 0 0 2 2 2 0 Zein-binding TPR_MLP1_2 PF07926.7 ESA12345.1 - 0.34 10.6 7.2 0.61 9.8 5.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TMCO5 PF14992.1 ESA12346.1 - 0.0021 17.2 6.0 0.0025 17.0 4.2 1.1 1 0 0 1 1 1 1 TMCO5 family AATF-Che1 PF13339.1 ESA12346.1 - 0.0043 17.2 1.8 0.0095 16.0 1.2 1.7 1 1 0 1 1 1 1 Apoptosis antagonizing transcription factor AAA_13 PF13166.1 ESA12346.1 - 0.0046 15.5 1.8 0.0051 15.3 1.2 1.0 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 ESA12346.1 - 0.0074 15.9 6.4 0.0099 15.4 4.4 1.2 1 0 0 1 1 1 1 IncA protein ATG16 PF08614.6 ESA12346.1 - 0.011 15.5 5.3 0.013 15.2 3.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ERM PF00769.14 ESA12346.1 - 0.023 14.2 3.1 0.024 14.1 2.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Mod_r PF07200.8 ESA12346.1 - 0.045 13.6 3.9 0.068 13.0 2.6 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein End3 PF12761.2 ESA12346.1 - 0.061 12.9 1.8 0.072 12.7 1.3 1.1 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Med4 PF10018.4 ESA12346.1 - 0.079 12.3 4.4 0.089 12.1 3.0 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 LRS4 PF10422.4 ESA12346.1 - 0.11 11.8 1.4 0.11 11.8 0.9 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF3450 PF11932.3 ESA12346.1 - 0.12 11.6 1.4 0.13 11.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Atg14 PF10186.4 ESA12346.1 - 0.13 11.1 2.9 0.16 10.9 2.0 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4200 PF13863.1 ESA12346.1 - 0.17 11.8 6.6 0.45 10.4 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF724 PF05266.9 ESA12346.1 - 0.18 11.3 2.8 0.21 11.1 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Fib_alpha PF08702.5 ESA12346.1 - 0.19 11.8 4.3 0.29 11.2 2.9 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF342 PF03961.8 ESA12346.1 - 0.22 9.8 3.1 0.24 9.7 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Rootletin PF15035.1 ESA12346.1 - 0.24 11.3 5.3 0.55 10.1 3.4 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CENP-Q PF13094.1 ESA12346.1 - 1 9.3 9.3 5.3 7.0 6.5 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TMF_DNA_bd PF12329.3 ESA12346.1 - 2.4 8.0 11.1 4.7 7.0 2.4 2.1 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESA12346.1 - 7 6.2 8.6 12 5.4 2.3 2.2 1 1 1 2 2 2 0 Septum formation initiator USP7_ICP0_bdg PF12436.3 ESA12348.1 - 1.6e-66 224.1 7.0 5.1e-65 219.1 0.8 2.4 2 0 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA12348.1 - 4.1e-57 193.0 8.1 4.1e-57 193.0 5.6 2.0 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH PF00443.24 ESA12348.1 - 1.5e-54 184.9 1.8 1.5e-54 184.9 1.3 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA12348.1 - 3.6e-32 111.9 0.0 1.1e-31 110.4 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 ESA12348.1 - 3.3e-08 33.7 0.1 3.3e-08 33.7 0.0 3.8 4 1 0 4 4 4 1 MATH domain Sel1 PF08238.7 ESA12349.1 - 4.5e-103 335.4 52.7 1.1e-10 41.7 0.3 13.7 14 0 0 14 14 14 12 Sel1 repeat TPR_6 PF13174.1 ESA12349.1 - 0.00072 19.8 14.6 3.8 8.1 0.0 9.1 10 0 0 10 10 10 1 Tetratricopeptide repeat DUF1730 PF08331.5 ESA12349.1 - 0.019 14.6 0.5 0.052 13.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) FRD2 PF03197.8 ESA12349.1 - 0.26 11.8 4.3 0.48 11.0 0.1 2.9 3 0 0 3 3 3 0 Bacteriophage FRD2 protein TPR_17 PF13431.1 ESA12349.1 - 1 9.7 0.0 1 9.7 0.0 8.7 11 1 0 11 11 11 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA12349.1 - 1.7 8.6 8.5 45 4.1 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat USP7_ICP0_bdg PF12436.3 ESA12351.1 - 2e-77 259.7 0.7 2e-77 259.7 0.5 1.6 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA12351.1 - 1e-56 191.7 5.2 1.3e-56 191.3 0.7 2.7 4 0 0 4 4 4 1 Ubiquitin-specific protease C-terminal FA_desaturase PF00487.19 ESA12352.1 - 3.3e-28 98.8 20.0 5e-28 98.2 13.9 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 ESA12352.1 - 1.5e-08 34.7 0.0 3.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Fungal_trans PF04082.13 ESA12353.1 - 1.3e-39 135.6 0.5 3.2e-39 134.3 0.4 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ESA12353.1 - 1.2e-11 44.3 10.6 1.9e-11 43.6 7.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_3 PF13302.1 ESA12354.1 - 1.8e-15 57.3 0.1 2.4e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA12354.1 - 3.6e-09 36.6 0.0 4.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA12354.1 - 6.3e-08 32.5 0.0 8.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 ESA12354.1 - 9.4e-08 32.1 0.2 1.3e-07 31.7 0.2 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESA12354.1 - 0.0004 20.4 0.2 0.00062 19.8 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PCI PF01399.22 ESA12355.1 - 3.1e-14 53.1 0.7 3.1e-14 53.1 0.5 2.6 2 1 0 2 2 2 1 PCI domain DEDD_Tnp_IS110 PF01548.12 ESA12355.1 - 0.037 13.6 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 Transposase MutS_IV PF05190.13 ESA12355.1 - 0.15 12.2 1.6 0.34 11.1 0.2 2.3 2 0 0 2 2 2 0 MutS family domain IV zf-C2H2 PF00096.21 ESA12356.1 - 0.003 17.8 2.1 0.0046 17.2 1.5 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA12356.1 - 0.023 14.8 0.9 0.041 14.0 0.6 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESA12356.1 - 0.026 14.4 0.7 0.04 13.8 0.5 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-FCS PF06467.9 ESA12356.1 - 0.043 13.4 0.7 0.07 12.7 0.5 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 PF13894.1 ESA12356.1 - 0.054 13.8 2.7 0.086 13.2 1.9 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger AT_hook PF02178.14 ESA12356.1 - 0.07 12.8 0.3 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 AT hook motif rve PF00665.21 ESA12357.1 - 1.8e-10 40.9 0.0 3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Slx4 PF09494.5 ESA12357.1 - 0.032 13.9 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Slx4 endonuclease Cwf_Cwc_15 PF04889.7 ESA12358.1 - 0.0031 17.2 6.1 0.012 15.3 4.6 1.7 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.3 ESA12358.1 - 0.0081 16.1 4.2 0.015 15.2 2.9 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.7 ESA12358.1 - 0.028 13.7 9.8 0.046 13.0 6.8 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 ESA12358.1 - 0.043 11.7 9.4 0.067 11.1 6.5 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA12358.1 - 0.086 10.8 5.7 0.15 10.1 4.0 1.3 1 0 0 1 1 1 0 CDC45-like protein GEMIN8 PF15348.1 ESA12358.1 - 0.28 11.1 9.0 0.017 15.1 2.6 1.5 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 CENP-B_dimeris PF09026.5 ESA12358.1 - 1.1 9.5 12.1 2.4 8.4 8.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.11 ESA12358.1 - 5.2 5.9 7.1 8.5 5.2 4.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PuR_N PF09182.5 ESA12359.1 - 0.13 11.9 0.1 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal Pkinase PF00069.20 ESA12361.1 - 3.2e-68 229.6 0.0 5.2e-68 228.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12361.1 - 2.7e-33 115.1 0.0 6.4e-33 113.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase EB1 PF03271.12 ESA12362.1 - 2e-18 66.1 1.1 3.7e-18 65.2 0.8 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 ESA12362.1 - 7.6e-05 22.7 0.4 0.00012 22.0 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Suppressor_APC PF11414.3 ESA12362.1 - 0.067 12.9 0.2 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein HSP33 PF01430.14 ESA12363.1 - 0.0046 16.1 0.2 0.0047 16.0 0.1 1.1 1 0 0 1 1 1 1 Hsp33 protein GrpE PF01025.14 ESA12363.1 - 0.048 13.2 3.2 0.11 12.0 2.2 1.6 1 1 0 1 1 1 0 GrpE Xpo1 PF08389.7 ESA12363.1 - 0.081 12.8 1.8 0.11 12.3 1.2 1.3 1 0 0 1 1 1 0 Exportin 1-like protein Sds3 PF08598.6 ESA12363.1 - 4 6.9 7.9 42 3.5 4.5 2.2 1 1 1 2 2 2 0 Sds3-like BTB PF00651.26 ESA12364.1 - 4.1e-08 33.1 0.8 7e-08 32.4 0.1 1.7 2 1 0 2 2 2 1 BTB/POZ domain DNA_pol3_gamma3 PF12169.3 ESA12364.1 - 4.9e-05 23.1 0.0 7e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III Beach PF02138.13 ESA12364.1 - 0.023 14.1 0.1 0.063 12.7 0.0 1.7 1 1 1 2 2 2 0 Beige/BEACH domain DUF4234 PF14018.1 ESA12366.1 - 0.00042 19.9 0.6 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4234) DUF912 PF06024.7 ESA12366.1 - 0.0048 16.9 3.9 0.075 13.0 0.2 2.1 2 0 0 2 2 2 2 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4366 PF14283.1 ESA12366.1 - 0.027 13.8 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Peptidase_M56 PF05569.6 ESA12366.1 - 0.037 12.9 0.1 0.08 11.9 0.0 1.5 2 0 0 2 2 2 0 BlaR1 peptidase M56 Plant_vir_prot PF01307.12 ESA12366.1 - 0.36 10.5 0.1 0.36 10.5 0.0 2.3 3 0 0 3 3 3 0 Plant viral movement protein Sel1 PF08238.7 ESA12367.1 - 1.9e-30 104.5 7.3 2.9e-08 34.0 0.1 5.0 5 0 0 5 5 5 5 Sel1 repeat DUF3991 PF13154.1 ESA12367.1 - 0.036 14.2 3.0 0.34 11.1 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3991) EDR1 PF14381.1 ESA12368.1 - 0.13 11.8 0.1 0.17 11.4 0.1 1.1 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 RNA_helicase PF00910.17 ESA12369.1 - 0.0016 18.5 0.0 0.0059 16.7 0.0 2.1 1 0 0 1 1 1 1 RNA helicase Arch_ATPase PF01637.13 ESA12369.1 - 0.0017 18.0 0.0 0.0043 16.7 0.0 1.8 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA12369.1 - 0.006 16.5 0.0 0.039 13.9 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESA12369.1 - 0.04 14.0 0.0 0.086 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 ESA12369.1 - 0.087 11.7 0.0 2.5 6.9 0.0 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 zf-ribbon_3 PF13248.1 ESA12370.1 - 0.19 10.9 1.2 0.38 10.0 0.8 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Pkinase_Tyr PF07714.12 ESA12371.1 - 3.2e-58 196.8 0.1 3.8e-48 163.8 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA12371.1 - 1.9e-54 184.5 1.4 7.8e-47 159.6 0.0 3.1 2 1 1 3 3 3 3 Protein kinase domain Kdo PF06293.9 ESA12371.1 - 0.00048 19.2 0.3 0.26 10.3 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA12371.1 - 0.0012 18.1 0.3 0.0047 16.1 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA12371.1 - 0.0086 15.8 0.3 0.019 14.6 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA12371.1 - 0.016 14.5 0.4 0.13 11.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family BTB PF00651.26 ESA12373.1 - 2.7e-16 59.5 0.4 6.1e-16 58.3 0.3 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA12373.1 - 0.00016 21.4 0.8 0.016 15.0 0.1 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch zf-FCS PF06467.9 ESA12373.1 - 0.07 12.7 0.1 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif MACPF PF01823.14 ESA12374.1 - 5.8e-09 35.9 6.7 1.1e-08 35.0 4.7 1.4 1 0 0 1 1 1 1 MAC/Perforin domain DUF4085 PF13315.1 ESA12374.1 - 0.36 10.1 7.6 2.7 7.2 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF4085) DUF659 PF04937.10 ESA12375.1 - 0.00066 19.1 0.6 0.045 13.2 0.1 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF 659) Allexi_40kDa PF05549.6 ESA12377.1 - 0.036 13.3 11.2 4.1 6.6 5.7 2.7 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF2313 PF10076.4 ESA12377.1 - 0.042 13.2 1.3 2.2 7.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2313) Mucin PF01456.12 ESA12377.1 - 5.4 6.7 8.9 13 5.4 6.2 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein RNase_H PF00075.19 ESA12379.1 - 5.5e-13 49.3 0.2 6.3e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 RNase H Xol-1_GHMP-like PF09109.5 ESA12379.1 - 0.024 14.7 0.4 0.033 14.2 0.3 1.1 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like ADH_zinc_N PF00107.21 ESA12380.1 - 5.3e-11 42.1 0.1 1.9e-10 40.3 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Cyc-maltodext_N PF09087.6 ESA12380.1 - 0.068 13.1 0.0 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 Cyclomaltodextrinase, N-terminal zf-ribbon_3 PF13248.1 ESA12381.1 - 0.5 9.6 9.2 3.5 6.9 1.6 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Thioredoxin_7 PF13899.1 ESA12381.1 - 0.88 9.6 10.8 37 4.4 0.0 5.2 4 1 1 5 5 5 0 Thioredoxin-like DUF983 PF06170.7 ESA12381.1 - 0.89 9.7 5.4 33 4.6 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF983) DnaJ_CXXCXGXG PF00684.14 ESA12381.1 - 2.8 8.0 13.8 2 8.5 0.8 3.2 3 0 0 3 3 3 0 DnaJ central domain Sel1 PF08238.7 ESA12382.1 - 1.8e-47 158.6 10.8 1.2e-12 48.0 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA12382.1 - 0.0004 20.6 11.8 3.5 8.2 0.1 5.5 6 0 0 6 6 6 4 Tetratricopeptide repeat MIT PF04212.13 ESA12382.1 - 0.02 14.7 12.5 7.3 6.5 0.0 5.1 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA12382.1 - 0.14 11.7 16.8 0.26 10.9 0.3 4.9 1 1 4 5 5 5 0 TPR repeat DUF807 PF05660.6 ESA12383.1 - 0.0055 16.3 0.9 0.94 9.1 0.0 2.3 1 1 1 2 2 2 2 Coxiella burnetii protein of unknown function (DUF807) DUF3926 PF13080.1 ESA12383.1 - 0.035 13.6 0.1 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) DUF2150 PF09920.4 ESA12383.1 - 0.12 11.9 0.2 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2150) DUF1132 PF06575.7 ESA12383.1 - 0.13 12.5 3.7 1 9.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1132) TLD PF07534.11 ESA12386.1 - 2.7e-18 66.3 0.6 6.6e-18 65.0 0.4 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA12386.1 - 8.2e-11 41.8 0.3 1.5e-10 41.0 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA12386.1 - 5.9e-05 22.8 2.4 0.00026 20.7 0.4 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA12386.1 - 0.045 13.8 0.4 0.2 11.8 0.0 2.3 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain HMG_box PF00505.14 ESA12387.1 - 7.6e-05 22.9 0.1 0.00013 22.2 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12387.1 - 0.053 13.9 0.1 0.076 13.3 0.1 1.2 1 0 0 1 1 1 0 HMG-box domain RHD3 PF05879.7 ESA12389.1 - 3.5e-07 28.5 0.1 9.1e-07 27.2 0.0 1.7 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.14 ESA12389.1 - 8.7e-06 24.9 0.1 1.7e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 ESA12389.1 - 0.044 13.5 0.1 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Dynamin family DDE_3 PF13358.1 ESA12390.1 - 3.9e-08 33.1 0.2 8.5e-08 32.0 0.1 1.6 1 1 1 2 2 2 1 DDE superfamily endonuclease PI31_Prot_N PF11566.3 ESA12391.1 - 0.036 13.6 1.9 1.3 8.5 1.1 2.1 2 0 0 2 2 2 0 PI31 proteasome regulator N-terminal Stap_Strp_toxin PF01123.15 ESA12391.1 - 0.11 12.9 1.6 0.15 12.5 0.3 1.8 1 1 0 1 1 1 0 Staphylococcal/Streptococcal toxin, OB-fold domain zf-Sec23_Sec24 PF04810.10 ESA12394.1 - 0.02 14.4 0.3 0.02 14.4 0.2 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger DUF2422 PF10337.4 ESA12397.1 - 2.1e-26 92.7 19.9 6.2e-18 64.8 0.0 3.8 3 1 1 4 4 4 3 Protein of unknown function (DUF2422) DUF2421 PF10334.4 ESA12397.1 - 2.6e-23 82.8 0.2 2.5e-22 79.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) FUSC_2 PF13515.1 ESA12397.1 - 2.4e-12 46.8 14.5 2.4e-12 46.8 10.0 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 ESA12397.1 - 9.6e-10 37.6 11.1 1.5e-07 30.4 2.0 2.2 2 0 0 2 2 2 2 Aluminium activated malate transporter FUSC PF04632.7 ESA12397.1 - 7e-07 28.0 18.7 4.5e-05 22.1 7.7 2.7 3 1 0 3 3 3 2 Fusaric acid resistance protein family DUF939 PF06081.6 ESA12397.1 - 0.13 12.1 24.7 0.015 15.1 4.7 4.0 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF939) zinc-ribbons_6 PF07191.7 ESA12399.1 - 0.0086 15.8 1.1 0.016 14.9 0.8 1.3 1 0 0 1 1 1 1 zinc-ribbons Pkinase_Tyr PF07714.12 ESA12399.1 - 0.015 14.4 0.0 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase WGR PF05406.10 ESA12400.1 - 0.083 12.8 0.3 0.32 10.9 0.1 2.0 2 0 0 2 2 2 0 WGR domain RNase_H PF00075.19 ESA12402.1 - 9.7e-06 25.9 0.1 0.012 15.9 0.0 2.8 2 1 1 3 3 3 2 RNase H PWI PF01480.12 ESA12402.1 - 0.0016 18.4 0.5 0.0053 16.8 0.3 1.9 2 0 0 2 2 2 1 PWI domain CRS1_YhbY PF01985.16 ESA12402.1 - 0.0098 15.8 0.4 0.024 14.6 0.1 1.8 2 0 0 2 2 2 1 CRS1 / YhbY (CRM) domain Rubredoxin PF00301.15 ESA12402.1 - 0.027 14.3 0.1 0.069 13.0 0.1 1.6 1 0 0 1 1 1 0 Rubredoxin Elf1 PF05129.8 ESA12402.1 - 0.097 12.3 0.4 0.24 11.1 0.3 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-RVT PF13966.1 ESA12402.1 - 0.1 12.9 0.4 0.29 11.4 0.3 1.8 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase MatP PF06303.7 ESA12404.1 - 0.027 14.3 0.3 0.049 13.5 0.2 1.5 1 1 0 1 1 1 0 Organiser of macrodomain of Terminus of chromosome F-box-like PF12937.2 ESA12405.1 - 7.6e-05 22.3 0.1 0.00021 20.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like ACOX PF01756.14 ESA12407.1 - 6.5e-42 143.0 1.6 1.1e-41 142.3 0.1 2.1 3 1 0 3 3 3 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.1 ESA12407.1 - 6.6e-33 113.6 0.0 1.5e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.14 ESA12407.1 - 6.5e-12 44.7 0.1 1.9e-11 43.3 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.19 ESA12407.1 - 0.0024 18.0 0.4 0.0092 16.0 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 ESA12407.1 - 0.009 16.5 0.0 0.039 14.5 0.0 2.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Z1 PF10593.4 ESA12407.1 - 0.033 13.4 0.4 0.07 12.3 0.0 1.7 2 0 0 2 2 2 0 Z1 domain PglZ PF08665.7 ESA12407.1 - 0.051 13.2 0.1 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 PglZ domain Abhydrolase_6 PF12697.2 ESA12408.1 - 2.6e-10 40.5 0.0 4.2e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA12408.1 - 6.6e-09 35.6 0.0 1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA12408.1 - 9.3e-06 25.3 0.1 0.0013 18.3 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold DUF915 PF06028.6 ESA12408.1 - 6.6e-05 22.1 2.8 0.00013 21.1 1.5 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DUF1749 PF08538.5 ESA12408.1 - 0.00091 18.1 0.1 0.0015 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.3 ESA12408.1 - 0.0022 17.8 1.0 0.024 14.4 0.1 2.8 2 1 1 3 3 3 1 Putative lysophospholipase Peptidase_S9 PF00326.16 ESA12408.1 - 0.034 13.3 0.3 0.17 11.0 0.2 2.0 1 1 0 1 1 1 0 Prolyl oligopeptidase family IFNGR1 PF07140.6 ESA12408.1 - 0.11 12.1 0.6 0.28 10.8 0.4 1.6 1 0 0 1 1 1 0 Interferon gamma receptor (IFNGR1) Lipoprotein_20 PF13942.1 ESA12410.1 - 0.05 13.1 0.2 0.69 9.4 0.0 2.0 1 1 0 2 2 2 0 YfhG lipoprotein Rep_2 PF01719.12 ESA12411.1 - 0.036 13.5 8.4 0.03 13.8 1.7 2.1 1 1 1 2 2 2 0 Plasmid replication protein FBP PF07299.6 ESA12413.1 - 0.054 12.8 5.0 2.5 7.3 0.8 2.2 2 0 0 2 2 2 0 Fibronectin-binding protein (FBP) Exo_endo_phos PF03372.18 ESA12414.1 - 0.0003 20.8 0.0 0.00048 20.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA12414.1 - 0.0058 16.2 3.2 0.022 14.3 2.2 2.1 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA12418.1 - 0.0018 18.2 0.0 0.0035 17.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA12418.1 - 0.0041 16.7 4.2 0.011 15.3 2.3 2.2 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Choline_kin_N PF04428.9 ESA12418.1 - 0.047 13.1 0.0 0.57 9.6 0.0 2.4 2 0 0 2 2 2 0 Choline kinase N terminus Coatomer_b_Cpla PF14806.1 ESA12420.1 - 0.035 13.8 0.3 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Coatomer beta subunit appendage platform zf-CCHC PF00098.18 ESA12420.1 - 7.4 6.6 7.7 18 5.4 0.5 2.5 2 0 0 2 2 2 0 Zinc knuckle Sigma_reg_N PF13800.1 ESA12421.1 - 1.2 9.1 8.3 2.4 8.2 5.7 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ASFV_J13L PF05568.6 ESA12421.1 - 7.9 5.9 5.8 9.6 5.6 4.0 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Pkinase PF00069.20 ESA12423.1 - 7.6e-31 107.1 0.1 7.6e-31 107.1 0.1 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12423.1 - 1e-30 106.6 0.0 1.7e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 ESA12423.1 - 9e-06 25.9 0.0 0.0012 19.1 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESA12423.1 - 2.1e-05 24.0 0.1 0.31 10.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 ESA12423.1 - 0.0029 18.0 0.9 6.9 7.3 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA12423.1 - 0.013 15.6 0.2 19 5.8 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.1 ESA12423.1 - 0.077 13.2 0.4 30 5.0 0.0 3.5 4 0 0 4 4 4 0 Ankyrin repeats (many copies) DUF705 PF05152.7 ESA12424.1 - 0.11 11.4 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF705) FtsK_SpoIIIE_N PF12538.3 ESA12425.1 - 0.0016 18.5 0.4 0.0047 17.0 0.1 2.0 2 0 0 2 2 2 1 DNA transporter Tachylectin PF14517.1 ESA12425.1 - 0.0074 15.6 0.1 1.6 8.0 0.0 2.1 2 0 0 2 2 2 2 Tachylectin DUF3019 PF11456.3 ESA12425.1 - 0.012 15.8 2.2 0.043 14.1 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3019) BBS2_Mid PF14783.1 ESA12425.1 - 0.12 12.1 0.7 0.36 10.6 0.1 2.1 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region TMPIT PF07851.8 ESA12427.1 - 0.034 13.2 1.3 0.041 12.9 0.9 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF2422 PF10337.4 ESA12427.1 - 0.041 12.6 0.3 0.045 12.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) UFC1 PF08694.6 ESA12427.1 - 0.043 13.2 0.0 0.045 13.2 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Fib_alpha PF08702.5 ESA12427.1 - 0.088 12.9 1.7 0.11 12.5 1.1 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FAR1 PF03101.10 ESA12429.1 - 0.047 14.2 0.2 0.091 13.2 0.1 1.5 1 0 0 1 1 1 0 FAR1 DNA-binding domain DUF3430 PF11912.3 ESA12430.1 - 0.017 14.9 0.5 0.025 14.3 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3430) PRA-CH PF01502.13 ESA12430.1 - 0.034 13.7 0.1 0.058 13.0 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl-AMP cyclohydrolase DUF3086 PF11285.3 ESA12431.1 - 0.016 14.0 0.1 0.017 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Laminin_I PF06008.9 ESA12431.1 - 0.029 13.6 0.3 0.037 13.3 0.2 1.1 1 0 0 1 1 1 0 Laminin Domain I Seryl_tRNA_N PF02403.17 ESA12431.1 - 0.034 14.1 0.6 0.043 13.8 0.4 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TaqI_C PF12950.2 ESA12431.1 - 0.08 12.6 0.2 0.085 12.6 0.1 1.1 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain ING PF12998.2 ESA12431.1 - 0.11 12.7 0.9 0.16 12.2 0.6 1.3 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding RGS PF00615.14 ESA12432.1 - 0.00029 20.9 0.2 0.019 15.0 0.0 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain TLD PF07534.11 ESA12434.1 - 1.9e-16 60.3 1.8 1.9e-16 60.3 1.2 2.0 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA12434.1 - 4.1e-06 26.5 0.3 2.2e-05 24.2 0.1 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch Dsl1_C PF11989.3 ESA12437.1 - 0.081 12.0 0.2 0.37 9.9 0.0 1.9 1 1 0 2 2 2 0 Retrograde transport protein Dsl1 C terminal MOR2-PAG1_C PF14225.1 ESA12439.1 - 0.0092 15.7 0.1 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 Cell morphogenesis C-terminal LSM PF01423.17 ESA12439.1 - 0.022 14.3 0.1 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 LSM domain Pkinase PF00069.20 ESA12441.1 - 2.4e-06 26.8 0.1 2.8e-06 26.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA12441.1 - 4.9e-06 26.0 0.0 6.7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA12441.1 - 0.00028 20.7 0.1 0.00035 20.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family F-box-like PF12937.2 ESA12442.1 - 0.00082 19.0 1.2 0.0032 17.1 0.2 2.4 2 0 0 2 2 2 1 F-box-like RPA_interact_M PF14767.1 ESA12443.1 - 0.017 15.8 5.1 0.021 15.5 3.5 1.3 1 0 0 1 1 1 0 Replication protein A interacting middle DDE_1 PF03184.14 ESA12444.1 - 1.6e-16 60.1 0.0 1.7e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA12444.1 - 0.00043 20.0 0.0 0.0005 19.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease ORC3_N PF07034.6 ESA12444.1 - 0.068 12.1 0.0 0.084 11.8 0.0 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Cas_Csn2 PF09711.5 ESA12444.1 - 0.12 12.0 0.0 0.13 11.9 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) TPR_14 PF13428.1 ESA12445.1 - 2.6e-28 95.9 15.3 0.034 14.7 0.0 10.9 4 3 7 11 11 11 9 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12445.1 - 3.9e-22 78.3 4.4 1.6e-05 25.3 0.0 7.0 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA12445.1 - 5.5e-21 74.6 6.2 0.00018 21.7 0.0 7.3 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA12445.1 - 6.6e-14 51.3 8.6 0.0037 16.8 0.1 7.7 5 3 3 8 8 8 2 TPR repeat TPR_2 PF07719.12 ESA12445.1 - 3.8e-12 45.1 9.7 0.42 10.6 0.0 10.0 13 0 0 13 13 12 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA12445.1 - 4.2e-10 39.4 0.8 1.5 9.4 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA12445.1 - 1.1e-08 34.2 3.0 0.47 10.3 0.0 7.4 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12445.1 - 1.1e-08 34.5 1.3 7.3 7.0 0.0 7.2 6 1 0 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.3 ESA12445.1 - 3.8e-07 29.2 0.2 0.0063 15.3 0.0 3.5 2 1 1 3 3 3 3 NMDA receptor-regulated protein 1 TPR_12 PF13424.1 ESA12445.1 - 1.4e-06 28.1 6.2 1.2 9.1 0.2 7.1 6 3 1 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA12445.1 - 3.4e-06 26.4 3.3 1.5 8.5 0.0 5.9 7 0 0 7 7 6 2 Tetratricopeptide repeat Suf PF05843.9 ESA12445.1 - 0.00051 19.8 0.1 0.54 9.9 0.0 3.6 2 1 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_21 PF09976.4 ESA12445.1 - 0.0042 17.0 7.6 0.0053 16.7 1.3 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA12445.1 - 0.0075 16.3 0.1 0.87 9.7 0.0 3.7 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3808 PF10300.4 ESA12445.1 - 0.044 12.3 1.1 33 2.8 0.0 3.8 3 1 2 5 5 5 0 Protein of unknown function (DUF3808) TPR_9 PF13371.1 ESA12445.1 - 0.067 13.0 3.7 5.4 6.9 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF4398 PF14346.1 ESA12445.1 - 5.3 7.1 9.3 1.1 9.3 1.0 3.3 3 1 1 4 4 3 0 Domain of unknown function (DUF4398) Complex1_LYR PF05347.10 ESA12446.1 - 6.9e-09 35.3 0.6 8.8e-09 35.0 0.4 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA12446.1 - 9.2e-08 32.1 0.5 1.2e-07 31.7 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like EntA_Immun PF08951.5 ESA12446.1 - 0.059 13.5 0.1 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 Enterocin A Immunity F5_F8_type_C PF00754.20 ESA12447.1 - 0.0015 18.3 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain Glycos_transf_2 PF00535.21 ESA12447.1 - 0.014 15.1 0.1 0.027 14.1 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF724 PF05266.9 ESA12448.1 - 1.4 8.5 16.4 0.32 10.5 3.5 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF724) TACC PF05010.9 ESA12448.1 - 1.5 8.5 17.8 2.3 7.9 6.8 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) Methyltransf_18 PF12847.2 ESA12449.1 - 6.8e-08 33.0 0.0 1.7e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA12449.1 - 2.8e-07 30.5 0.0 4.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA12449.1 - 5e-05 23.5 0.0 0.00017 21.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA12449.1 - 0.00033 21.0 0.0 0.0011 19.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 ESA12449.1 - 0.0026 17.1 0.5 0.016 14.4 0.3 2.1 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.7 ESA12449.1 - 0.024 15.1 0.0 0.096 13.1 0.0 2.1 3 0 0 3 3 3 0 Methyltransferase domain CheR PF01739.13 ESA12449.1 - 0.069 12.4 1.5 0.14 11.4 0.3 2.0 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain DUF188 PF02639.9 ESA12449.1 - 0.078 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 FAD_binding_4 PF01565.18 ESA12451.1 - 5.1e-31 106.9 0.0 1.2e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.14 ESA12451.1 - 6.6e-16 58.3 0.0 9.2e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain G-patch PF01585.18 ESA12452.1 - 1.3e-12 47.3 1.3 2e-12 46.6 0.9 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA12452.1 - 1.8e-05 24.5 2.1 1.8e-05 24.5 0.4 1.8 2 0 0 2 2 2 1 DExH-box splicing factor binding site ATP-synt_C PF00137.16 ESA12453.1 - 3.6e-30 103.6 27.1 7.1e-17 61.0 8.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C G0-G1_switch_2 PF15103.1 ESA12453.1 - 0.17 12.1 0.8 0.76 10.0 0.2 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 Sel1 PF08238.7 ESA12454.1 - 7.1e-70 229.9 7.4 5e-10 39.6 0.0 8.0 8 0 0 8 8 8 7 Sel1 repeat EF-hand_10 PF14788.1 ESA12454.1 - 4.1e-05 23.1 0.1 17 5.1 0.0 5.5 6 0 0 6 6 6 0 EF hand MIT PF04212.13 ESA12454.1 - 0.00025 20.8 9.5 3.3 7.6 0.9 5.7 4 1 2 6 6 6 2 MIT (microtubule interacting and transport) domain DUF2685 PF10886.3 ESA12454.1 - 0.00072 19.5 0.2 14 5.7 0.0 4.3 4 0 0 4 4 4 1 Protein of unknown function (DUF2685) AdoMet_MTase PF07757.8 ESA12454.1 - 0.001 19.1 5.5 25 5.0 0.0 5.3 1 1 5 6 6 6 0 Predicted AdoMet-dependent methyltransferase TFIIB PF00382.14 ESA12454.1 - 0.002 17.8 0.5 20 5.0 0.0 5.2 1 1 5 6 6 6 0 Transcription factor TFIIB repeat DUF3731 PF12531.3 ESA12454.1 - 0.0037 16.8 0.1 86 2.5 0.0 5.1 2 1 2 6 6 6 0 DNA-K related protein Methyltransf_7 PF03492.10 ESA12454.1 - 0.39 9.4 1.9 61 2.2 0.0 3.7 3 1 1 4 4 4 0 SAM dependent carboxyl methyltransferase ATP-synt_DE PF00401.15 ESA12454.1 - 1.5 8.7 8.3 93 3.0 0.1 4.4 4 0 0 4 4 4 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain TPR_12 PF13424.1 ESA12454.1 - 8.1 6.4 18.3 18 5.3 0.3 6.0 2 2 5 7 7 7 0 Tetratricopeptide repeat PriCT_1 PF08708.6 ESA12455.1 - 0.051 13.3 0.4 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Primase C terminal 1 (PriCT-1) RVT_1 PF00078.22 ESA12456.1 - 6.4e-14 51.8 0.1 1.7e-13 50.4 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-L PF13092.1 ESA12457.1 - 4.6e-11 42.7 0.1 6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 CLASP_N PF12348.3 ESA12458.1 - 2.6e-13 49.8 0.8 6.6e-13 48.5 0.6 1.7 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.17 ESA12458.1 - 0.13 12.3 0.1 21 5.5 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat UPF0121 PF03661.8 ESA12459.1 - 8.6e-12 44.7 5.7 1.1e-11 44.4 3.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Pex2_Pex12 PF04757.9 ESA12459.1 - 0.036 13.4 4.0 0.074 12.4 2.8 1.5 1 1 1 2 2 2 0 Pex2 / Pex12 amino terminal region AOX PF01786.12 ESA12459.1 - 0.47 9.8 4.4 0.76 9.1 2.9 1.4 1 1 0 1 1 1 0 Alternative oxidase DUF2101 PF09874.4 ESA12459.1 - 3.6 7.0 11.8 5.1 6.5 2.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) Apc15p PF05841.6 ESA12460.1 - 3.5 8.3 10.3 3 8.5 6.1 1.6 1 1 0 1 1 1 0 Apc15p protein Rogdi_lz PF10259.4 ESA12461.1 - 2.1e-33 115.5 0.1 1.3e-32 112.9 0.0 1.8 1 1 0 1 1 1 1 Rogdi leucine zipper containing protein PROCN PF08083.6 ESA12462.1 - 2.6e-223 740.8 6.2 4e-223 740.2 4.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 ESA12462.1 - 5.6e-128 425.0 0.9 9.6e-128 424.2 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 ESA12462.1 - 8.6e-92 304.7 1.1 1.8e-91 303.7 0.8 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 ESA12462.1 - 2.4e-82 274.0 3.9 2.4e-82 274.0 2.7 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 ESA12462.1 - 1.9e-67 225.0 0.1 3.9e-67 224.0 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 ESA12462.1 - 6.6e-52 174.4 0.3 1.6e-51 173.2 0.2 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.4 ESA12462.1 - 6.2e-45 150.9 0.7 1.8e-44 149.5 0.5 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 Tricho_coat PF05892.6 ESA12463.1 - 0.07 12.3 0.0 0.071 12.3 0.0 1.0 1 0 0 1 1 1 0 Trichovirus coat protein FAR1 PF03101.10 ESA12464.1 - 4.1e-07 30.4 3.6 6.2e-07 29.8 2.5 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain MULE PF10551.4 ESA12465.1 - 1.3e-13 50.8 0.0 3.2e-13 49.6 0.0 1.6 2 0 0 2 2 2 1 MULE transposase domain FAR1 PF03101.10 ESA12466.1 - 3.4e-12 46.7 1.0 5.9e-12 45.9 0.7 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain MULE PF10551.4 ESA12466.1 - 1.1e-05 25.5 0.0 6.5e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 MULE transposase domain DBD_Tnp_Mut PF03108.10 ESA12466.1 - 0.011 15.3 1.5 1.6 8.3 0.0 2.6 2 0 0 2 2 2 0 MuDR family transposase AFT PF08731.6 ESA12466.1 - 0.012 15.7 0.1 0.02 15.0 0.1 1.5 1 0 0 1 1 1 0 Transcription factor AFT NAD_binding_10 PF13460.1 ESA12467.1 - 5.1e-08 33.1 0.0 7e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESA12467.1 - 0.00024 20.5 0.1 0.00047 19.6 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ESA12467.1 - 0.002 17.1 0.0 0.5 9.2 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Semialdhyde_dh PF01118.19 ESA12467.1 - 0.0022 18.2 0.0 0.015 15.5 0.0 2.0 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain PRE_C2HC PF07530.6 ESA12467.1 - 0.11 12.3 0.2 0.33 10.8 0.0 1.9 2 0 0 2 2 2 0 Associated with zinc fingers ThiF PF00899.16 ESA12467.1 - 0.12 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 ThiF family PARP PF00644.15 ESA12468.1 - 9.1e-05 21.9 0.1 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SRF-TF PF00319.13 ESA12470.1 - 0.17 11.1 0.6 0.36 10.0 0.4 1.7 1 1 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) BCIP PF13862.1 ESA12471.1 - 0.026 14.0 0.5 0.033 13.7 0.3 1.1 1 0 0 1 1 1 0 p21-C-terminal region-binding protein SRP1_TIP1 PF00660.12 ESA12474.1 - 0.97 9.2 5.9 3.6 7.4 0.3 2.6 2 2 0 2 2 2 0 Seripauperin and TIP1 family Pkinase_Tyr PF07714.12 ESA12475.1 - 3.4e-31 108.2 0.0 3.7e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12475.1 - 7.3e-28 97.4 0.1 8.1e-28 97.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA12475.1 - 7.6e-05 21.8 0.0 7.6e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA12475.1 - 0.0076 16.0 0.1 0.0092 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA12475.1 - 0.0082 15.5 0.1 0.0098 15.2 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA12475.1 - 0.024 13.5 0.0 0.026 13.4 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Ph1570 PF09638.5 ESA12477.1 - 5.4e-05 23.0 0.3 0.014 15.1 0.0 2.3 2 0 0 2 2 2 2 Ph1570 protein Phage-A118_gp45 PF10653.4 ESA12477.1 - 7.7e-05 22.4 0.1 2.1 8.2 0.0 3.9 4 0 0 4 4 4 1 Protein gp45 of Bacteriophage A118 DUF3669 PF12417.3 ESA12477.1 - 0.0025 17.5 0.0 0.34 10.6 0.0 2.6 3 0 0 3 3 3 1 Zinc finger protein Glyco_hydro_11 PF00457.12 ESA12477.1 - 0.0059 15.9 9.6 0.16 11.3 0.6 2.9 1 1 1 2 2 2 2 Glycosyl hydrolases family 11 BCS1_N PF08740.6 ESA12477.1 - 0.016 14.7 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 BCS1 N terminal NAC PF01849.13 ESA12477.1 - 0.19 11.2 1.0 21 4.7 0.0 2.7 3 0 0 3 3 3 0 NAC domain Pkinase_Tyr PF07714.12 ESA12479.1 - 8.1e-31 107.0 1.0 1e-30 106.6 0.7 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12479.1 - 8.6e-29 100.4 3.1 1.1e-28 100.0 2.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA12479.1 - 0.00064 18.7 0.0 0.0018 17.2 0.0 1.6 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA12479.1 - 0.047 12.7 0.1 0.076 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SpvB PF03534.8 ESA12479.1 - 0.048 12.6 0.5 0.083 11.8 0.3 1.4 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein NAD_binding_10 PF13460.1 ESA12481.1 - 4.3e-17 62.7 0.0 1e-16 61.4 0.0 1.6 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESA12481.1 - 3.8e-10 39.6 0.0 1.3e-09 37.8 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 ESA12481.1 - 8.4e-09 35.0 0.0 1.4e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 ESA12481.1 - 1.5e-05 24.0 0.0 5.7e-05 22.1 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain DapB_N PF01113.15 ESA12481.1 - 2.9e-05 23.9 0.0 6.4e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.14 ESA12481.1 - 5.8e-05 21.9 0.0 0.00088 18.0 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.12 ESA12481.1 - 0.0072 16.7 0.1 0.054 13.9 0.0 2.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.10 ESA12481.1 - 0.0074 15.2 0.0 0.95 8.2 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein UDPG_MGDP_dh_N PF03721.9 ESA12481.1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short PF00106.20 ESA12481.1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.13 ESA12481.1 - 0.064 13.2 0.1 0.16 12.0 0.0 1.6 2 0 0 2 2 2 0 TrkA-N domain KR PF08659.5 ESA12481.1 - 0.15 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 KR domain DUF2935 PF11155.3 ESA12482.1 - 0.012 15.6 2.4 0.015 15.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) YfcL PF08891.6 ESA12482.1 - 0.024 14.5 2.6 1.7 8.6 0.1 2.1 1 1 1 2 2 2 0 YfcL protein ATG16 PF08614.6 ESA12482.1 - 0.026 14.3 9.4 0.038 13.8 6.5 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) SCHIP-1 PF10148.4 ESA12482.1 - 0.028 13.8 0.3 0.031 13.6 0.2 1.2 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Cauli_AT PF03233.8 ESA12482.1 - 0.055 13.1 8.1 0.042 13.5 3.5 1.8 1 1 1 2 2 2 0 Aphid transmission protein AATF-Che1 PF13339.1 ESA12482.1 - 0.081 13.0 4.4 0.098 12.8 3.0 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF643 PF04867.7 ESA12482.1 - 0.083 13.2 4.1 0.11 12.9 2.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF643) Mlp PF03304.8 ESA12482.1 - 0.13 12.2 9.7 0.11 12.5 1.5 2.0 1 1 1 2 2 2 0 Mlp lipoprotein family Cytochrom_C_2 PF01322.15 ESA12482.1 - 0.14 12.7 0.7 0.25 11.9 0.5 1.3 1 1 0 1 1 1 0 Cytochrome C' DUF948 PF06103.6 ESA12482.1 - 0.16 11.8 0.2 0.21 11.4 0.2 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF106 PF01956.11 ESA12482.1 - 0.24 10.9 2.6 0.27 10.7 1.8 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 Gp-FAR-1 PF05823.7 ESA12482.1 - 0.31 10.9 9.3 4.8 7.1 4.4 2.0 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Pup PF05639.6 ESA12482.1 - 0.6 10.6 8.5 0.12 12.8 1.7 2.3 1 1 1 2 2 2 0 Pup-like protein Atg14 PF10186.4 ESA12482.1 - 0.7 8.7 6.9 0.74 8.6 4.8 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF87 PF01935.12 ESA12482.1 - 1 9.0 7.1 1.2 8.9 4.9 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF87 Ax_dynein_light PF10211.4 ESA12482.1 - 1.5 8.6 11.6 1.4 8.6 7.4 1.4 1 1 0 1 1 1 0 Axonemal dynein light chain DUF1451 PF07295.6 ESA12482.1 - 1.6 8.4 6.0 12 5.6 4.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1451) TMPIT PF07851.8 ESA12482.1 - 3.6 6.5 6.2 4 6.4 4.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein Bap31 PF05529.7 ESA12482.1 - 5.3 6.4 7.2 2.9 7.3 4.0 1.4 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like LMF1 PF06762.9 ESA12484.1 - 0.08 11.7 0.3 0.077 11.7 0.2 1.0 1 0 0 1 1 1 0 Lipase maturation factor TLD PF07534.11 ESA12486.1 - 1.6e-13 50.8 2.0 2.8e-13 50.0 0.2 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA12486.1 - 2.2e-05 24.1 0.8 7.3e-05 22.5 0.2 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch RNase_T PF00929.19 ESA12486.1 - 0.094 12.9 0.1 15 5.8 0.0 2.4 1 1 1 2 2 2 0 Exonuclease TPR_11 PF13414.1 ESA12487.1 - 7.1e-20 70.4 32.3 6.2e-06 25.7 1.3 4.9 3 1 2 5 5 5 5 TPR repeat TPR_2 PF07719.12 ESA12487.1 - 3.3e-15 54.6 22.0 0.00025 20.7 0.0 6.0 7 0 0 7 7 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA12487.1 - 1e-10 41.5 19.1 2.6e-06 27.4 0.3 3.5 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESA12487.1 - 5.7e-09 35.2 34.8 9.5e-05 21.8 0.1 7.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA12487.1 - 1.8e-08 33.5 18.6 0.07 12.9 0.1 5.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA12487.1 - 2.3e-08 33.8 11.0 0.079 12.8 0.1 4.8 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12487.1 - 8.7e-08 32.6 0.0 0.033 14.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA12487.1 - 1.8e-06 28.2 0.4 0.13 12.5 0.2 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12487.1 - 2.1e-06 27.4 27.3 0.043 14.0 0.3 7.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA12487.1 - 0.00015 21.5 0.0 0.21 11.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat zf-C3HC4_3 PF13920.1 ESA12487.1 - 0.0009 18.8 2.9 0.0017 17.9 2.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA12487.1 - 0.0025 17.5 3.6 0.0057 16.3 2.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain TPR_6 PF13174.1 ESA12487.1 - 0.0028 18.0 0.2 12 6.5 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA12487.1 - 0.0094 16.5 0.0 3.9 8.3 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA12487.1 - 0.05 13.4 7.0 4.1 7.4 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-RING_2 PF13639.1 ESA12487.1 - 0.12 12.2 2.5 0.28 11.0 1.7 1.7 1 0 0 1 1 1 0 Ring finger domain Fis1_TPR_C PF14853.1 ESA12487.1 - 0.45 10.4 0.0 0.45 10.4 0.0 5.1 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat zf-RING_UBOX PF13445.1 ESA12487.1 - 1 9.1 7.8 7.4 6.3 5.0 2.7 2 0 0 2 2 2 0 RING-type zinc-finger Pkinase PF00069.20 ESA12488.1 - 7.7e-65 218.6 0.8 1.6e-64 217.5 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12488.1 - 2.2e-43 148.1 0.0 2.1e-42 145.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA12488.1 - 2.1e-07 30.2 0.0 3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA12488.1 - 0.00088 18.6 0.2 0.003 16.9 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA12488.1 - 0.011 14.8 0.1 0.018 14.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA12488.1 - 0.052 13.2 0.0 0.16 11.6 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA12488.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.1 ESA12488.1 - 0.093 12.3 0.5 0.67 9.5 0.0 2.3 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 KcnmB2_inactiv PF09303.5 ESA12488.1 - 3.7 7.4 5.1 5.8 6.7 0.0 3.3 4 0 0 4 4 4 0 KCNMB2, ball and chain domain UPF0220 PF05255.6 ESA12490.1 - 1.7e-38 131.4 5.9 2e-38 131.2 4.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) PSII PF00421.14 ESA12490.1 - 0.015 13.8 0.8 0.02 13.5 0.5 1.2 1 0 0 1 1 1 0 Photosystem II protein RVT_1 PF00078.22 ESA12491.1 - 8.9e-11 41.5 0.0 6.4e-09 35.4 0.0 2.4 1 1 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Pep3_Vps18 PF05131.9 ESA12493.1 - 6.5e-50 168.3 0.2 2.5e-49 166.5 0.0 2.1 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.15 ESA12493.1 - 9.8e-13 47.9 18.4 2.7e-10 40.0 2.7 3.4 3 1 0 3 3 3 2 Region in Clathrin and VPS Vps39_2 PF10367.4 ESA12493.1 - 0.00024 21.2 0.2 0.0017 18.4 0.1 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.1 ESA12493.1 - 0.00033 20.4 1.7 0.00091 19.0 0.7 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 ESA12493.1 - 0.00059 19.5 1.0 0.0014 18.3 0.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA12493.1 - 0.00092 19.1 1.1 0.0022 18.0 0.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA12493.1 - 0.013 15.1 0.9 0.03 14.0 0.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA12493.1 - 0.021 14.9 0.3 0.094 12.8 0.1 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger zf-Apc11 PF12861.2 ESA12493.1 - 0.088 12.6 0.0 1.7 8.5 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_1 PF00515.23 ESA12493.1 - 5.6 6.7 8.7 31 4.3 0.6 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Complex1_LYR PF05347.10 ESA12494.1 - 5.2e-06 26.1 0.1 1.3e-05 24.8 0.1 1.7 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA12494.1 - 7.9e-06 25.9 0.1 1.8e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Complex1_LYR-like SPO22 PF08631.5 ESA12496.1 - 6e-25 87.8 6.2 6e-25 87.8 4.3 3.4 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.12 ESA12496.1 - 6.2 6.9 0.0 6.2 6.9 0.0 6.1 8 0 0 8 8 8 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA12498.1 - 2.4e-23 82.5 0.1 3.3e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12498.1 - 1.2e-21 77.0 3.9 4.6e-21 75.1 2.7 1.9 1 1 0 1 1 1 1 Protein kinase domain RVT_1 PF00078.22 ESA12500.1 - 0.0011 18.3 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 ESA12501.1 - 1.7e-16 60.7 0.1 2e-16 60.5 0.1 1.0 1 0 0 1 1 1 1 RNase H Npa1 PF11707.3 ESA12502.1 - 1.2e-67 228.2 12.5 1.2e-67 228.2 8.7 3.1 3 0 0 3 3 3 1 Ribosome 60S biogenesis N-terminal MACPF PF01823.14 ESA12505.1 - 4.7e-08 32.9 2.4 1e-07 31.8 1.7 1.6 1 0 0 1 1 1 1 MAC/Perforin domain Pkinase_Tyr PF07714.12 ESA12507.1 - 3e-42 144.4 0.0 5.3e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12507.1 - 1.9e-34 118.9 1.1 2.6e-34 118.5 0.2 1.5 2 0 0 2 2 2 1 Protein kinase domain RVT_1 PF00078.22 ESA12509.1 - 6.8e-19 68.0 0.0 1.5e-18 66.9 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_M1 PF01433.15 ESA12511.1 - 1.8e-83 280.7 0.0 2.3e-83 280.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 ESA12511.1 - 2.6e-41 140.5 0.7 4.7e-41 139.7 0.2 1.7 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 ESA12511.1 - 8.4e-14 51.7 0.0 1.3e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 ESA12511.1 - 0.3 11.0 1.6 1.2 9.1 1.1 1.9 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Gryzun PF07919.7 ESA12512.1 - 1.7e-47 162.0 6.5 2.3e-47 161.5 4.5 1.2 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.3 ESA12512.1 - 6.3e-14 52.0 1.5 9e-14 51.5 1.1 1.2 1 0 0 1 1 1 1 Foie gras liver health family 1 TRAPPC10 PF12584.3 ESA12512.1 - 0.00022 20.7 0.1 0.0005 19.5 0.0 1.6 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 TPR_7 PF13176.1 ESA12512.1 - 0.0063 16.2 0.2 0.052 13.3 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA12512.1 - 0.01 15.7 0.2 0.022 14.6 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA12512.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA12512.1 - 0.013 15.1 0.1 0.028 14.0 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA12512.1 - 0.045 13.6 0.4 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat UPF0180 PF03698.8 ESA12512.1 - 0.054 13.3 0.3 15 5.4 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Gryzun-like PF12742.2 ESA12512.1 - 0.093 12.5 0.1 0.23 11.2 0.1 1.7 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking TPR_8 PF13181.1 ESA12512.1 - 0.14 11.9 0.2 0.47 10.3 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12512.1 - 0.19 12.4 0.0 0.38 11.4 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1146 PF06612.6 ESA12513.1 - 0.057 13.3 0.6 0.11 12.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1146) Spore_GerQ PF09671.5 ESA12513.1 - 0.063 12.9 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Spore coat protein (Spore_GerQ) CheF-arch PF04283.7 ESA12513.1 - 0.065 12.4 0.6 0.099 11.8 0.3 1.4 1 1 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea SporV_AA PF12164.3 ESA12513.1 - 0.071 13.1 0.4 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AA PIGA PF08288.7 ESA12514.1 - 0.032 14.5 0.9 0.19 12.0 0.1 2.2 2 0 0 2 2 2 0 PIGA (GPI anchor biosynthesis) Staphostatin_A PF09022.5 ESA12515.1 - 0.03 14.1 0.9 0.041 13.7 0.5 1.4 1 1 0 1 1 1 0 Staphostatin A DUF1772 PF08592.6 ESA12516.1 - 3.2 7.4 6.7 5.7 6.6 2.9 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF1772) Keratin_assoc PF09775.4 ESA12517.1 - 0.23 11.0 3.9 0.2 11.1 2.0 1.4 1 1 0 1 1 1 0 Keratinocyte-associated protein 2 Haemagg_act PF05860.8 ESA12518.1 - 1 9.1 4.2 1.7 8.4 2.9 1.6 1 1 0 1 1 1 0 haemagglutination activity domain Prenyltrans PF00432.16 ESA12519.1 - 0.024 14.2 2.2 2.2 7.9 1.5 2.4 1 1 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat Ribophorin_II PF05817.9 ESA12520.1 - 3.9e-46 157.5 0.6 5.1e-46 157.1 0.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF4401 PF14351.1 ESA12520.1 - 0.0018 17.2 5.4 0.0032 16.4 3.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4401) TPR_1 PF00515.23 ESA12521.1 - 2e-36 122.0 15.0 3e-06 26.5 0.0 9.8 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.12 ESA12521.1 - 1.1e-35 118.6 10.9 4.1e-05 23.1 0.2 10.7 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_11 PF13414.1 ESA12521.1 - 1.1e-34 117.8 10.4 7e-10 38.4 0.0 7.9 5 2 4 9 9 9 7 TPR repeat TPR_12 PF13424.1 ESA12521.1 - 2.7e-28 97.7 5.8 1e-08 34.9 0.0 7.7 5 2 3 8 8 8 5 Tetratricopeptide repeat Apc3 PF12895.2 ESA12521.1 - 2.7e-27 94.7 11.6 3.2e-20 72.0 0.3 5.1 4 1 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESA12521.1 - 1.5e-20 71.3 13.2 0.00015 21.2 0.4 8.0 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12521.1 - 5.4e-18 65.1 0.0 0.00015 22.2 0.0 6.9 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA12521.1 - 3.2e-14 53.0 1.5 0.67 10.3 0.0 7.3 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESA12521.1 - 2.2e-12 45.7 9.3 0.0007 19.2 0.0 7.7 8 1 0 8 8 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA12521.1 - 2.8e-12 46.1 1.5 0.017 15.7 0.0 8.3 5 4 5 10 10 8 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12521.1 - 9e-11 41.0 6.4 1.8 8.9 0.0 7.1 8 0 0 8 8 5 4 Tetratricopeptide repeat TPR_10 PF13374.1 ESA12521.1 - 6.6e-10 38.6 2.5 0.17 11.8 0.0 7.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA12521.1 - 9.3e-10 38.3 14.8 0.029 14.8 0.0 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_3 PF07720.7 ESA12521.1 - 4.5e-05 23.1 15.4 4.4 7.2 0.1 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA12521.1 - 0.0032 16.5 0.5 9.4 5.1 0.0 4.1 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESA12521.1 - 0.014 15.2 1.2 7.4 6.5 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat PPR PF01535.15 ESA12521.1 - 0.059 13.3 4.6 11 6.2 0.0 4.8 4 0 0 4 4 4 0 PPR repeat PseudoU_synth_1 PF01416.15 ESA12522.1 - 6.8e-37 126.0 0.0 1.5e-21 76.8 0.0 3.4 4 0 0 4 4 4 2 tRNA pseudouridine synthase SNF2_N PF00176.18 ESA12523.1 - 1.6e-55 188.0 0.0 3.2e-55 187.0 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESA12523.1 - 5.5e-15 54.9 0.0 1.2e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 ESA12523.1 - 7.4e-08 31.5 0.2 2.4e-07 29.8 0.1 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 ESA12523.1 - 0.0016 18.3 0.0 0.014 15.2 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 ESA12523.1 - 0.035 14.2 0.5 3.6 7.7 0.0 3.7 3 2 1 4 4 4 0 AAA domain DUF2075 PF09848.4 ESA12523.1 - 0.085 11.8 0.1 1.3 7.9 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) WD40 PF00400.27 ESA12524.1 - 3.5e-16 58.3 6.0 3.3e-07 29.9 0.0 4.8 6 0 0 6 6 6 3 WD domain, G-beta repeat API5 PF05918.6 ESA12525.1 - 2.2e-25 89.2 0.1 2.6e-25 88.9 0.1 1.0 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.1 ESA12525.1 - 0.0013 18.9 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 HEAT repeats Barstar PF01337.13 ESA12525.1 - 0.0016 18.2 0.1 0.0034 17.1 0.0 1.6 1 0 0 1 1 1 1 Barstar (barnase inhibitor) Adaptin_N PF01602.15 ESA12525.1 - 0.027 12.8 0.0 0.034 12.4 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 ESA12525.1 - 0.047 14.0 0.1 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.17 ESA12525.1 - 0.051 13.6 0.1 0.31 11.2 0.0 2.3 3 0 0 3 3 3 0 HEAT repeat API5 PF05918.6 ESA12526.1 - 0.0014 17.2 20.5 0.99 7.8 14.2 2.0 1 1 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) DUF3074 PF11274.3 ESA12526.1 - 0.0024 17.5 1.2 0.0036 16.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Mnd1 PF03962.10 ESA12526.1 - 0.77 9.3 6.8 0.08 12.6 0.9 1.9 2 0 0 2 2 2 0 Mnd1 family PITH PF06201.8 ESA12527.1 - 2.4e-48 163.7 0.0 3e-48 163.4 0.0 1.1 1 0 0 1 1 1 1 PITH domain zf-BED PF02892.10 ESA12528.1 - 0.00016 21.3 2.5 0.00016 21.3 1.7 1.5 2 0 0 2 2 2 1 BED zinc finger FYRC PF05965.9 ESA12528.1 - 0.0084 15.8 0.5 0.012 15.4 0.3 1.3 1 1 0 1 1 1 1 F/Y rich C-terminus zf-U11-48K PF05253.7 ESA12528.1 - 0.047 13.4 0.8 0.1 12.3 0.6 1.5 1 0 0 1 1 1 0 U11-48K-like CHHC zinc finger TPX2_importin PF12214.3 ESA12530.1 - 2.6e-07 30.8 6.3 2.6e-07 30.8 4.4 2.1 2 0 0 2 2 2 1 Cell cycle regulated microtubule associated protein FAT PF02259.18 ESA12531.1 - 6.1e-127 423.4 7.7 6.1e-127 423.4 5.4 2.7 3 0 0 3 3 3 1 FAT domain Rapamycin_bind PF08771.6 ESA12531.1 - 1.4e-38 130.9 1.7 1.4e-38 130.9 1.1 3.3 3 0 0 3 3 3 1 Rapamycin binding domain TPR_19 PF14559.1 ESA12531.1 - 1.5e-06 28.4 0.0 0.81 10.0 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12531.1 - 5.6e-05 23.6 0.0 0.28 11.8 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA12531.1 - 6.7e-05 22.4 2.4 0.017 14.8 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA12531.1 - 0.0044 17.1 5.9 2.6 8.2 0.0 4.2 3 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA12531.1 - 0.0072 16.1 7.0 3.2 7.8 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA12531.1 - 0.05 14.2 5.1 2.9 8.7 0.1 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TRI12 PF06609.8 ESA12531.1 - 0.098 10.8 0.0 0.16 10.1 0.0 1.2 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) TPR_1 PF00515.23 ESA12531.1 - 8.3 6.1 8.6 6 6.6 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat HMG_box PF00505.14 ESA12532.1 - 1.4e-11 44.5 2.0 3e-11 43.4 1.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12532.1 - 1.1e-07 32.0 1.7 2.3e-07 31.0 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain USP7_ICP0_bdg PF12436.3 ESA12533.1 - 6.1e-14 51.8 0.4 5.5e-12 45.4 0.0 2.1 2 0 0 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA12533.1 - 2.6e-13 49.9 4.7 3.6e-13 49.4 3.3 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal rve PF00665.21 ESA12534.1 - 1.2e-07 31.7 0.0 2.9e-07 30.5 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Pkinase_Tyr PF07714.12 ESA12535.1 - 1.6e-05 24.0 0.8 1.7e-05 24.0 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12535.1 - 7.6e-05 21.9 6.2 0.00063 18.9 4.3 1.9 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA12535.1 - 0.00078 19.2 0.1 0.00095 18.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA12535.1 - 0.0017 17.7 2.0 0.0028 17.0 1.4 1.7 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA12535.1 - 0.11 11.5 0.3 0.18 10.8 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family p450 PF00067.17 ESA12536.1 - 8.2e-44 149.8 0.0 8.9e-44 149.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB_2 PF02214.17 ESA12539.1 - 5.3e-18 65.0 1.2 4.6e-17 62.0 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain Alpha_adaptinC2 PF02883.15 ESA12539.1 - 0.31 11.3 3.8 0.6 10.4 2.7 1.4 1 0 0 1 1 1 0 Adaptin C-terminal domain F-box-like PF12937.2 ESA12540.1 - 2.8e-05 23.7 0.0 4.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 F-box-like BTB PF00651.26 ESA12541.1 - 3.1e-13 49.6 0.6 5.4e-13 48.9 0.4 1.4 1 0 0 1 1 1 1 BTB/POZ domain Mito_fiss_reg PF05308.6 ESA12542.1 - 1.4 8.1 6.1 2.2 7.6 4.2 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3006 PF11213.3 ESA12544.1 - 0.047 13.4 1.1 0.087 12.5 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3006) Peptidase_S49_N PF08496.5 ESA12544.1 - 3.3 7.5 6.1 4.2 7.1 4.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Dimer_Tnp_hAT PF05699.9 ESA12545.1 - 1.5e-07 30.9 0.1 3.1e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TLD PF07534.11 ESA12546.1 - 1.6e-13 50.7 1.1 2.3e-13 50.3 0.8 1.2 1 0 0 1 1 1 1 TLD DUF3942 PF13078.1 ESA12546.1 - 0.088 12.9 3.0 0.052 13.6 0.7 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3942) CTK3 PF12243.3 ESA12547.1 - 0.13 11.9 0.1 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 HMG_box PF00505.14 ESA12548.1 - 1.3e-08 34.9 1.0 1.9e-08 34.4 0.7 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12548.1 - 9.7e-06 25.8 0.7 1.5e-05 25.2 0.5 1.3 1 0 0 1 1 1 1 HMG-box domain DUF1074 PF06382.6 ESA12548.1 - 0.022 14.7 0.9 0.039 13.9 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1074) TPR_11 PF13414.1 ESA12549.1 - 7.7e-22 76.7 28.8 5.5e-10 38.7 0.3 4.2 2 1 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 ESA12549.1 - 4.8e-21 72.9 15.9 2e-06 27.2 0.1 6.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESA12549.1 - 3.1e-18 64.5 28.5 5.7e-08 32.0 0.6 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA12549.1 - 1.8e-11 42.9 32.1 4.7e-05 22.8 0.4 6.7 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA12549.1 - 4.1e-10 40.0 0.0 0.0029 18.2 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA12549.1 - 7.7e-10 38.5 12.9 0.00027 20.8 0.3 4.3 3 1 2 5 5 5 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA12549.1 - 7.5e-09 35.6 26.2 1.5e-05 25.0 2.6 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESA12549.1 - 7.7e-07 28.8 0.0 0.0013 18.5 0.0 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA12549.1 - 1.3e-06 28.5 0.0 6 7.8 0.0 5.1 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA12549.1 - 1.8e-05 24.5 18.6 0.47 10.7 0.1 6.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA12549.1 - 1.8e-05 24.9 4.7 0.063 13.6 0.0 4.3 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA12549.1 - 6.8e-05 23.0 7.9 0.12 12.8 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat zf-RING_UBOX PF13445.1 ESA12549.1 - 0.0011 18.5 4.8 0.0057 16.3 3.3 2.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA12549.1 - 0.046 13.6 1.3 0.14 12.0 0.9 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 ESA12549.1 - 0.065 12.9 2.3 0.17 11.6 1.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA12549.1 - 0.16 11.7 1.9 0.36 10.7 1.3 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 ESA12549.1 - 0.4 10.4 6.7 0.19 11.4 2.7 2.0 2 0 0 2 2 1 0 zinc-RING finger domain TPR_7 PF13176.1 ESA12549.1 - 2 8.3 6.7 68 3.6 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA12549.1 - 5.1 7.0 20.1 2.2 8.2 0.2 5.8 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat NmrA PF05368.8 ESA12550.1 - 1.5e-26 93.0 0.2 1.4e-18 67.0 0.0 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.1 ESA12550.1 - 1.6e-09 38.0 0.0 2.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding TrkA_N PF02254.13 ESA12550.1 - 1.7e-06 27.9 0.1 2.8e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 TrkA-N domain CbiK PF06180.6 ESA12550.1 - 0.0022 17.1 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Saccharop_dh PF03435.13 ESA12550.1 - 0.008 15.1 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase 3Beta_HSD PF01073.14 ESA12550.1 - 0.019 13.6 0.0 0.03 13.0 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_zinc_N PF00107.21 ESA12551.1 - 1.7e-20 72.8 0.1 3.1e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA12551.1 - 4.7e-20 72.7 0.0 8.4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA12551.1 - 4.1e-09 36.1 0.0 1.7e-08 34.1 0.0 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.19 ESA12551.1 - 0.0066 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 ESA12551.1 - 0.013 15.5 0.1 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 NADH(P)-binding AlaDh_PNT_C PF01262.16 ESA12551.1 - 0.017 14.7 0.1 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Eno-Rase_NADH_b PF12242.3 ESA12551.1 - 0.029 14.1 0.0 0.064 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Patatin PF01734.17 ESA12553.1 - 9.7e-06 25.6 0.2 1.4e-05 25.1 0.1 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase Patatin PF01734.17 ESA12554.1 - 0.0001 22.2 0.0 0.00011 22.1 0.0 1.1 1 0 0 1 1 1 1 Patatin-like phospholipase p450 PF00067.17 ESA12555.1 - 1e-37 129.8 0.6 1.1e-37 129.6 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF496 PF04363.7 ESA12555.1 - 0.13 12.0 3.7 3.7 7.4 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF496) MAM1 PF10434.4 ESA12556.1 - 0.024 13.8 1.4 0.026 13.7 0.9 1.1 1 0 0 1 1 1 0 Monopolin complex protein MAM1 Phage_min_tail PF05939.8 ESA12556.1 - 0.084 12.8 0.2 0.52 10.2 0.0 1.9 2 0 0 2 2 2 0 Phage minor tail protein AsmA_1 PF13109.1 ESA12556.1 - 0.1 11.8 0.1 0.5 9.6 0.0 1.8 1 1 1 2 2 2 0 AsmA-like C-terminal region HrpF PF06266.7 ESA12556.1 - 0.11 12.6 0.5 0.23 11.6 0.4 1.6 1 1 0 1 1 1 0 HrpF protein Dna2 PF08696.6 ESA12556.1 - 0.16 11.2 1.5 0.42 9.8 0.1 1.8 1 1 1 2 2 2 0 DNA replication factor Dna2 DUF3298 PF11738.3 ESA12558.1 - 0.8 10.2 5.5 1.8 9.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3298) p450 PF00067.17 ESA12559.1 - 3.1e-39 134.7 1.2 3.4e-39 134.6 0.9 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA12560.1 - 6.2e-20 71.1 0.2 7.6e-20 70.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tic20 PF09685.5 ESA12561.1 - 0.9 9.5 5.0 1.4 8.9 3.4 1.5 1 1 0 1 1 1 0 Tic20-like protein BTB PF00651.26 ESA12562.1 - 3.6e-20 71.9 0.5 4.2e-20 71.7 0.4 1.0 1 0 0 1 1 1 1 BTB/POZ domain p450 PF00067.17 ESA12563.1 - 2.7e-20 72.3 0.3 4e-17 61.8 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 FAM165 PF14981.1 ESA12564.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 FAM165 family Ibs_toxin PF13956.1 ESA12564.1 - 2.3 8.0 6.9 2.8 7.8 3.6 2.0 2 0 0 2 2 2 0 Toxin Ibs, type I toxin-antitoxin system Pkinase PF00069.20 ESA12567.1 - 1.3e-69 234.2 0.0 4.1e-69 232.6 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12567.1 - 1.5e-51 174.9 0.0 2.8e-51 174.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.1 ESA12567.1 - 2.5e-18 65.9 0.8 4.9e-18 64.9 0.6 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 ESA12567.1 - 7.3e-13 48.1 1.5 1.5e-12 47.2 0.4 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA12567.1 - 3.4e-12 46.3 0.7 1e-11 44.8 0.5 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.18 ESA12567.1 - 1.4e-09 38.3 0.1 3.1e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.1 ESA12567.1 - 6.6e-07 28.5 0.0 6.6e-06 25.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Ste50p-SAM PF09235.5 ESA12567.1 - 0.017 15.1 1.8 0.16 11.9 0.3 2.9 2 0 0 2 2 2 0 Ste50p, sterile alpha motif SAM_PNT PF02198.11 ESA12567.1 - 0.05 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain TLD PF07534.11 ESA12568.1 - 6.2e-10 39.1 1.6 8.3e-10 38.8 0.2 1.9 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA12568.1 - 4.6e-08 33.0 0.1 9.7e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA12568.1 - 3.4e-07 30.0 1.5 1e-05 25.3 0.3 3.4 1 1 2 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA12569.1 - 3e-13 49.4 0.1 3.5e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12569.1 - 1.4e-11 44.0 0.3 1.6e-11 43.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Rad54_N PF08658.5 ESA12570.1 - 0.062 13.0 0.8 0.07 12.8 0.6 1.0 1 0 0 1 1 1 0 Rad54 N terminal Pkinase_Tyr PF07714.12 ESA12571.1 - 1.6e-13 50.3 0.1 1.8e-13 50.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12571.1 - 1.3e-10 40.8 0.4 1.6e-10 40.5 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain PCI_Csn8 PF10075.4 ESA12571.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 Snf7 PF03357.16 ESA12573.1 - 7e-22 77.6 6.8 7e-22 77.6 4.7 2.0 3 0 0 3 3 3 1 Snf7 DUF4094 PF13334.1 ESA12573.1 - 0.015 15.6 0.4 0.015 15.6 0.3 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4094) Syntaxin-6_N PF09177.6 ESA12573.1 - 3.4 8.1 10.4 0.25 11.7 0.7 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal COG2 PF06148.6 ESA12573.1 - 3.7 7.4 8.7 2.1 8.2 1.6 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 WD40 PF00400.27 ESA12575.1 - 4.7e-13 48.4 19.7 7e-08 32.0 0.5 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat Rav1p_C PF12234.3 ESA12575.1 - 0.0028 15.8 1.9 0.0097 14.1 0.1 2.2 1 1 0 2 2 2 1 RAVE protein 1 C terminal Seryl_tRNA_N PF02403.17 ESA12576.1 - 0.82 9.7 21.0 0.25 11.3 12.8 1.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RNA_pol_Rpb1_5 PF04998.12 ESA12576.1 - 0.91 8.7 12.0 1.1 8.4 8.3 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 BPL_N PF09825.4 ESA12576.1 - 3.2 6.4 8.3 3.6 6.2 5.8 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal NARP1 PF12569.3 ESA12576.1 - 4.1 6.0 18.8 4.8 5.8 13.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ATP11 PF06644.6 ESA12576.1 - 4.9 6.5 18.8 6.5 6.1 13.0 1.1 1 0 0 1 1 1 0 ATP11 protein SR-25 PF10500.4 ESA12576.1 - 5.3 6.4 27.9 56 3.1 19.4 1.9 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein FLO_LFY PF01698.11 ESA12576.1 - 5.7 5.6 15.2 6.6 5.4 10.5 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein GAGA_bind PF06217.7 ESA12576.1 - 9.1 6.1 16.0 11 5.9 11.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Arf PF00025.16 ESA12577.1 - 2e-78 261.5 0.2 2.4e-78 261.3 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 ESA12577.1 - 9.6e-13 47.5 0.4 1.2e-08 34.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 ESA12577.1 - 1.3e-12 47.3 0.0 1.7e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESA12577.1 - 1.2e-11 44.1 0.0 1.4e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESA12577.1 - 4.2e-11 42.4 0.0 5e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA12577.1 - 1.2e-08 35.4 0.0 1.6e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 ESA12577.1 - 9e-06 25.2 0.2 0.00014 21.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA12577.1 - 3.3e-05 23.8 0.0 4.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.14 ESA12577.1 - 0.0017 17.7 0.3 0.62 9.4 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 ESA12577.1 - 0.0062 15.3 1.1 0.25 10.0 0.1 2.7 2 1 0 2 2 2 1 ArgK protein ABC_tran PF00005.22 ESA12577.1 - 0.066 13.5 0.2 0.11 12.8 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Filament PF00038.16 ESA12578.1 - 1.6e-05 24.5 7.6 2.6e-05 23.8 5.3 1.3 1 0 0 1 1 1 1 Intermediate filament protein Spc7 PF08317.6 ESA12578.1 - 0.00099 17.8 3.6 0.0013 17.4 2.5 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein GAS PF13851.1 ESA12578.1 - 0.002 17.3 3.9 0.0044 16.2 2.7 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 ESA12578.1 - 0.002 16.6 4.8 0.0025 16.3 3.3 1.1 1 0 0 1 1 1 1 AAA domain IncA PF04156.9 ESA12578.1 - 0.0023 17.5 6.6 0.0059 16.2 4.4 1.8 1 1 1 2 2 2 1 IncA protein DUF883 PF05957.8 ESA12578.1 - 0.0023 18.2 2.4 0.029 14.7 1.7 2.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF883) CENP-F_leu_zip PF10473.4 ESA12578.1 - 0.0033 17.2 8.8 0.0033 17.2 6.1 2.2 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.14 ESA12578.1 - 0.005 14.6 5.5 0.006 14.3 3.8 1.1 1 0 0 1 1 1 1 Myosin tail DUF3584 PF12128.3 ESA12578.1 - 0.011 13.1 8.1 0.013 12.8 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TMF_TATA_bd PF12325.3 ESA12578.1 - 0.014 15.0 3.8 0.032 13.9 2.6 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Reo_sigmaC PF04582.7 ESA12578.1 - 0.015 14.4 12.3 0.028 13.6 8.4 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 ESA12578.1 - 0.016 15.0 3.5 0.016 15.0 2.5 2.5 2 1 1 3 3 2 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.7 ESA12578.1 - 0.016 14.9 5.7 0.031 14.1 4.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_I PF06008.9 ESA12578.1 - 0.018 14.3 8.7 0.027 13.7 6.1 1.2 1 0 0 1 1 1 0 Laminin Domain I zf-C2H2_4 PF13894.1 ESA12578.1 - 0.021 15.1 0.4 0.062 13.6 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Syntaxin-6_N PF09177.6 ESA12578.1 - 0.021 15.1 11.6 1.3 9.5 3.9 2.9 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TSC22 PF01166.13 ESA12578.1 - 0.029 14.3 2.2 0.42 10.6 0.0 3.2 3 1 1 4 4 2 0 TSC-22/dip/bun family Atg14 PF10186.4 ESA12578.1 - 0.052 12.4 7.6 0.084 11.8 5.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Fez1 PF06818.10 ESA12578.1 - 0.058 13.4 6.7 0.079 12.9 4.6 1.1 1 0 0 1 1 1 0 Fez1 DUF892 PF05974.7 ESA12578.1 - 0.068 12.9 6.6 0.12 12.1 4.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF892) CENP-Q PF13094.1 ESA12578.1 - 0.071 13.1 12.4 0.25 11.3 8.6 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HAUS-augmin3 PF14932.1 ESA12578.1 - 0.073 12.2 12.1 0.043 12.9 6.8 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 KLRAQ PF10205.4 ESA12578.1 - 0.091 12.8 4.5 0.24 11.4 3.1 1.7 2 0 0 2 2 1 0 Predicted coiled-coil domain-containing protein TBPIP PF07106.8 ESA12578.1 - 0.093 12.2 10.2 0.046 13.2 4.5 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HisKA_3 PF07730.8 ESA12578.1 - 0.094 13.0 2.1 14 6.1 0.6 2.5 1 1 1 2 2 2 0 Histidine kinase DUF2422 PF10337.4 ESA12578.1 - 0.1 11.3 2.7 0.15 10.7 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) ORF6C PF10552.4 ESA12578.1 - 0.1 12.3 2.6 0.17 11.6 1.6 1.5 1 1 0 1 1 1 0 ORF6C domain DUF948 PF06103.6 ESA12578.1 - 0.11 12.3 9.3 0.17 11.7 0.9 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.7 ESA12578.1 - 0.14 11.9 9.5 0.2 11.4 4.3 2.1 1 1 1 2 2 2 0 Laminin Domain II Tropomyosin PF00261.15 ESA12578.1 - 0.15 11.1 9.3 0.042 12.9 3.9 1.9 2 1 0 2 2 1 0 Tropomyosin ALMT PF11744.3 ESA12578.1 - 0.16 10.6 2.6 0.19 10.3 1.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Sipho_Gp157 PF05565.6 ESA12578.1 - 0.17 11.4 4.0 0.31 10.6 2.3 1.7 1 1 1 2 2 2 0 Siphovirus Gp157 DUF2580 PF10824.3 ESA12578.1 - 0.3 11.4 3.9 1.6 9.1 2.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2580) MscS_porin PF12795.2 ESA12578.1 - 0.4 9.9 15.1 0.72 9.1 1.5 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain KxDL PF10241.4 ESA12578.1 - 0.4 10.5 5.1 0.28 11.1 2.2 1.7 2 0 0 2 2 1 0 Uncharacterized conserved protein DivIC PF04977.10 ESA12578.1 - 0.4 10.1 6.2 0.54 9.7 0.2 3.2 1 1 2 3 3 3 0 Septum formation initiator Fib_alpha PF08702.5 ESA12578.1 - 0.42 10.7 11.2 2.4 8.3 1.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.6 ESA12578.1 - 0.46 10.4 4.0 7.2 6.5 0.7 2.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Tropomyosin_1 PF12718.2 ESA12578.1 - 0.46 10.3 11.1 0.36 10.6 6.2 1.7 1 1 0 1 1 1 0 Tropomyosin like DUF4200 PF13863.1 ESA12578.1 - 0.48 10.3 8.2 16 5.4 3.3 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) RP-C_C PF11800.3 ESA12578.1 - 0.7 9.5 9.1 2.3 7.8 6.3 1.7 1 1 0 1 1 1 0 Replication protein C C-terminal region Phage_GP20 PF06810.6 ESA12578.1 - 0.92 8.9 9.5 0.78 9.1 5.2 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF2072 PF09845.4 ESA12578.1 - 0.93 9.4 3.5 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) DUF3810 PF12725.2 ESA12578.1 - 0.95 8.2 4.0 0.74 8.6 1.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Seryl_tRNA_N PF02403.17 ESA12578.1 - 0.97 9.4 6.9 11 6.0 4.8 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BBP1_C PF15272.1 ESA12578.1 - 0.97 8.9 11.8 1.9 8.0 5.3 2.0 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal NPV_P10 PF05531.7 ESA12578.1 - 1.3 9.3 6.5 38 4.6 4.5 2.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF1675 PF07897.6 ESA12578.1 - 1.5 8.6 8.1 2 8.2 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) COG2 PF06148.6 ESA12578.1 - 1.7 8.4 7.0 4.3 7.2 3.0 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Prominin PF05478.6 ESA12578.1 - 1.8 6.0 8.0 3.2 5.1 5.4 1.4 1 1 0 1 1 1 0 Prominin DUF2203 PF09969.4 ESA12578.1 - 1.9 8.7 5.1 37 4.5 3.3 2.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.7 ESA12578.1 - 2.1 8.1 6.8 1.3 8.8 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF972 PF06156.8 ESA12578.1 - 4.1 7.8 9.2 32 4.9 6.3 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Mnd1 PF03962.10 ESA12578.1 - 4.4 6.9 11.7 1.2 8.8 6.0 1.6 2 1 0 2 2 1 0 Mnd1 family DUF1451 PF07295.6 ESA12578.1 - 5.2 6.8 10.2 9.7 5.9 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1451) TEX13 PF15186.1 ESA12578.1 - 6.6 6.2 9.4 3.3 7.2 4.2 2.0 1 1 0 1 1 1 0 Testis-expressed sequence 13 protein family YlqD PF11068.3 ESA12578.1 - 7.1 6.6 10.4 5.9 6.9 5.1 2.0 1 1 1 2 2 2 0 YlqD protein DUF802 PF05650.6 ESA12578.1 - 8.2 6.6 11.6 4.5 7.4 1.7 2.7 2 1 1 3 3 2 0 Domain of unknown function (DUF802) YbhQ PF11076.3 ESA12579.1 - 0.1 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ FAM165 PF14981.1 ESA12579.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 FAM165 family Ibs_toxin PF13956.1 ESA12579.1 - 2.5 8.0 7.0 2.8 7.8 3.6 2.0 2 0 0 2 2 2 0 Toxin Ibs, type I toxin-antitoxin system p450 PF00067.17 ESA12580.1 - 6.1e-08 31.6 0.2 7e-08 31.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lipin_N PF04571.9 ESA12581.1 - 0.1 12.2 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 lipin, N-terminal conserved region F-box-like PF12937.2 ESA12582.1 - 2.2e-06 27.3 0.5 5.5e-06 26.0 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA12582.1 - 0.0061 16.1 0.1 0.025 14.2 0.1 2.1 1 0 0 1 1 1 1 F-box domain Rapamycin_bind PF08771.6 ESA12582.1 - 0.025 14.6 0.9 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Rapamycin binding domain EB1_binding PF05937.6 ESA12583.1 - 0.0061 16.9 0.1 0.0099 16.2 0.1 1.3 1 0 0 1 1 1 1 EB-1 Binding Domain Reo_sigmaC PF04582.7 ESA12583.1 - 0.024 13.8 1.0 0.031 13.4 0.7 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CENP-F_leu_zip PF10473.4 ESA12583.1 - 0.067 13.0 1.8 0.071 12.9 0.1 1.8 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-C2H2_4 PF13894.1 ESA12583.1 - 0.072 13.4 0.8 0.18 12.2 0.3 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger RP-C_C PF11800.3 ESA12583.1 - 0.082 12.5 1.2 0.12 12.1 0.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF948 PF06103.6 ESA12583.1 - 0.084 12.7 0.2 0.21 11.4 0.2 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) RseC_MucC PF04246.7 ESA12584.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC LRR_7 PF13504.1 ESA12587.1 - 0.013 15.5 2.4 48 4.8 0.0 4.5 3 1 0 3 3 3 0 Leucine rich repeat LRR_2 PF07723.8 ESA12587.1 - 0.11 13.0 1.4 24 5.6 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 ESA12587.1 - 0.71 10.1 5.6 68 3.9 0.1 4.3 5 0 0 5 5 5 0 Leucine Rich repeat DUF1295 PF06966.7 ESA12588.1 - 2e-41 141.8 18.8 5.1e-41 140.5 13.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 ESA12588.1 - 0.0016 18.5 3.0 0.0021 18.1 0.2 2.6 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.9 ESA12588.1 - 0.0041 17.2 0.0 0.0041 17.2 0.0 2.9 3 1 1 4 4 4 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family T_cell_tran_alt PF15128.1 ESA12588.1 - 0.035 13.5 0.1 0.13 11.7 0.1 1.9 1 0 0 1 1 1 0 T-cell leukemia translocation-altered HXXEE PF13787.1 ESA12588.1 - 1.9 8.9 19.8 0.44 10.9 1.1 3.2 2 1 0 3 3 3 0 Protein of unknown function with HXXEE motif Abhydrolase_3 PF07859.8 ESA12589.1 - 1.3e-24 86.9 0.0 1.7e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 ESA12589.1 - 1.1e-18 67.3 0.0 2.8e-18 65.9 0.0 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 ESA12589.1 - 5e-12 45.7 0.0 7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESA12589.1 - 2.9e-08 33.1 0.0 1.5e-07 30.8 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.8 ESA12589.1 - 2.2e-05 24.0 0.0 3.8e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 ESA12589.1 - 0.00013 21.9 0.0 0.00019 21.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.6 ESA12589.1 - 0.00074 19.2 0.1 0.0033 17.1 0.1 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase_phd PF10503.4 ESA12589.1 - 0.00087 18.5 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 2 Esterase PHB depolymerase Abhydrolase_2 PF02230.11 ESA12589.1 - 0.0028 17.1 0.1 0.45 9.9 0.0 2.8 1 1 1 3 3 3 1 Phospholipase/Carboxylesterase DLH PF01738.13 ESA12589.1 - 0.016 14.4 0.0 0.055 12.7 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.15 ESA12589.1 - 0.053 13.0 0.0 0.98 8.9 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 ESA12589.1 - 0.076 11.8 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme BTB PF00651.26 ESA12591.1 - 9.1e-07 28.8 0.1 2.5e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA12591.1 - 1.1e-06 28.4 0.1 3.8e-05 23.4 0.0 3.0 1 1 1 2 2 2 1 BTB And C-terminal Kelch Clathrin PF00637.15 ESA12591.1 - 0.09 12.3 5.6 0.15 11.6 0.7 2.7 3 0 0 3 3 3 0 Region in Clathrin and VPS Ribosomal_L30_N PF08079.7 ESA12592.1 - 2.5e-26 91.4 16.9 5.3e-26 90.4 11.7 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 ESA12592.1 - 2.8e-20 71.6 3.1 5.2e-20 70.7 1.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Toprim_C_rpt PF13368.1 ESA12592.1 - 0.91 10.0 7.4 3.1 8.3 2.9 2.4 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat NIF PF03031.13 ESA12593.1 - 1.1e-55 187.6 0.6 1.6e-55 187.0 0.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Filament PF00038.16 ESA12594.1 - 2.4e-05 23.9 7.1 3.9e-05 23.2 4.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein IncA PF04156.9 ESA12594.1 - 0.00021 20.9 1.3 0.00037 20.1 0.9 1.5 1 0 0 1 1 1 1 IncA protein Reo_sigmaC PF04582.7 ESA12594.1 - 0.00029 20.1 5.9 0.00045 19.5 4.1 1.3 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Spc7 PF08317.6 ESA12594.1 - 0.00041 19.1 2.3 0.00053 18.7 1.6 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein AAA_13 PF13166.1 ESA12594.1 - 0.00065 18.3 2.4 0.00077 18.0 1.7 1.1 1 0 0 1 1 1 1 AAA domain DUF3584 PF12128.3 ESA12594.1 - 0.0012 16.3 6.0 0.0014 16.0 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF892 PF05974.7 ESA12594.1 - 0.0021 17.9 1.3 0.0047 16.7 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF892) CENP-F_leu_zip PF10473.4 ESA12594.1 - 0.0029 17.4 8.3 0.0029 17.4 5.7 2.0 2 1 0 2 2 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_tail_1 PF01576.14 ESA12594.1 - 0.0038 15.0 5.0 0.0046 14.7 3.5 1.1 1 0 0 1 1 1 1 Myosin tail DUF883 PF05957.8 ESA12594.1 - 0.0039 17.5 2.3 0.037 14.4 1.5 2.1 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF883) Baculo_PEP_C PF04513.7 ESA12594.1 - 0.0041 16.9 4.3 0.0069 16.2 3.0 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.1 ESA12594.1 - 0.016 14.4 6.0 0.043 13.0 4.1 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Syntaxin-6_N PF09177.6 ESA12594.1 - 0.017 15.4 10.1 2.3 8.6 3.6 2.8 1 1 1 3 3 3 0 Syntaxin 6, N-terminal Tropomyosin PF00261.15 ESA12594.1 - 0.017 14.1 5.4 0.063 12.3 3.7 1.8 1 1 0 1 1 1 0 Tropomyosin zf-C2H2_4 PF13894.1 ESA12594.1 - 0.02 15.2 0.4 0.062 13.6 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger TMF_DNA_bd PF12329.3 ESA12594.1 - 0.021 14.6 3.5 0.021 14.6 2.4 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding CUT PF02376.10 ESA12594.1 - 0.021 14.6 0.2 0.051 13.3 0.0 1.7 2 0 0 2 2 1 0 CUT domain Laminin_I PF06008.9 ESA12594.1 - 0.021 14.1 8.0 0.032 13.5 5.5 1.2 1 0 0 1 1 1 0 Laminin Domain I TSC22 PF01166.13 ESA12594.1 - 0.024 14.6 1.8 0.42 10.6 0.0 3.2 3 1 1 4 4 3 0 TSC-22/dip/bun family Mnd1 PF03962.10 ESA12594.1 - 0.033 13.8 3.6 0.061 12.9 2.5 1.5 1 0 0 1 1 1 0 Mnd1 family ORF6C PF10552.4 ESA12594.1 - 0.067 12.9 1.6 0.13 12.0 1.1 1.5 1 0 0 1 1 1 0 ORF6C domain DUF948 PF06103.6 ESA12594.1 - 0.07 13.0 8.9 0.14 12.0 1.1 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) HisKA_3 PF07730.8 ESA12594.1 - 0.091 13.1 1.8 19 5.6 0.2 2.5 1 1 1 2 2 2 0 Histidine kinase Prominin PF05478.6 ESA12594.1 - 0.11 10.0 4.5 0.14 9.6 3.1 1.3 1 0 0 1 1 1 0 Prominin CENP-Q PF13094.1 ESA12594.1 - 0.13 12.2 11.3 0.11 12.4 6.1 1.7 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fez1 PF06818.10 ESA12594.1 - 0.13 12.2 5.7 0.18 11.8 4.0 1.1 1 0 0 1 1 1 0 Fez1 Sipho_Gp157 PF05565.6 ESA12594.1 - 0.15 11.6 3.7 0.31 10.6 2.2 1.7 1 1 0 1 1 1 0 Siphovirus Gp157 Atg14 PF10186.4 ESA12594.1 - 0.16 10.8 7.4 0.25 10.2 5.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Laminin_II PF06009.7 ESA12594.1 - 0.19 11.5 8.4 0.37 10.5 2.5 2.1 1 1 1 2 2 2 0 Laminin Domain II DivIC PF04977.10 ESA12594.1 - 0.2 11.1 4.9 0.48 9.9 0.2 3.2 1 1 2 3 3 3 0 Septum formation initiator TBPIP PF07106.8 ESA12594.1 - 0.2 11.2 9.8 0.1 12.1 4.3 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ALMT PF11744.3 ESA12594.1 - 0.21 10.2 2.2 0.25 9.9 1.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2422 PF10337.4 ESA12594.1 - 0.28 9.9 3.6 0.38 9.5 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Bacillus_HBL PF05791.6 ESA12594.1 - 0.3 10.4 7.6 0.52 9.6 3.1 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FlaC_arch PF05377.6 ESA12594.1 - 0.31 10.9 4.3 4.1 7.3 0.9 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) KLRAQ PF10205.4 ESA12594.1 - 0.35 10.9 5.7 0.27 11.2 2.9 1.6 2 0 0 2 2 1 0 Predicted coiled-coil domain-containing protein DUF4407 PF14362.1 ESA12594.1 - 0.36 9.7 3.2 0.49 9.2 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.5 ESA12594.1 - 0.38 10.8 11.3 3.3 7.8 1.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HAUS-augmin3 PF14932.1 ESA12594.1 - 0.41 9.8 12.0 0.33 10.0 6.9 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF2072 PF09845.4 ESA12594.1 - 0.61 10.0 2.8 3.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Tropomyosin_1 PF12718.2 ESA12594.1 - 0.63 9.8 10.3 0.57 10.0 6.0 1.7 1 1 0 1 1 1 0 Tropomyosin like RP-C_C PF11800.3 ESA12594.1 - 0.64 9.6 8.1 2.1 7.9 5.6 1.7 1 1 0 1 1 1 0 Replication protein C C-terminal region DUF3810 PF12725.2 ESA12594.1 - 0.76 8.6 3.5 0.59 8.9 1.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF4200 PF13863.1 ESA12594.1 - 0.82 9.6 7.8 2 8.3 1.6 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) BBP1_C PF15272.1 ESA12594.1 - 0.95 8.9 11.5 2.1 7.8 5.3 2.0 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal Phage_GP20 PF06810.6 ESA12594.1 - 1.1 8.7 8.7 0.7 9.3 4.4 1.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 Seryl_tRNA_N PF02403.17 ESA12594.1 - 1.2 9.1 6.3 12 6.0 4.4 2.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.6 ESA12594.1 - 1.8 8.4 6.4 11 5.9 4.1 2.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.7 ESA12594.1 - 2.3 8.0 5.8 1.9 8.3 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF972 PF06156.8 ESA12594.1 - 2.3 8.5 7.3 13 6.1 5.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DUF2203 PF09969.4 ESA12594.1 - 2.9 8.1 5.2 74 3.5 0.0 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1451 PF07295.6 ESA12594.1 - 5.5 6.7 9.5 9.7 5.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1451) TEX13 PF15186.1 ESA12594.1 - 6.2 6.3 9.3 2.7 7.5 3.7 2.2 1 1 1 3 3 3 0 Testis-expressed sequence 13 protein family TMPIT PF07851.8 ESA12594.1 - 8.4 5.3 7.2 17 4.3 5.0 1.5 1 1 0 1 1 1 0 TMPIT-like protein YlqD PF11068.3 ESA12594.1 - 9.8 6.2 9.8 29 4.7 6.0 2.1 1 1 1 2 2 2 0 YlqD protein Pkinase_Tyr PF07714.12 ESA12598.1 - 1.4e-21 76.7 0.0 1.5e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12598.1 - 2.2e-18 66.3 0.0 2.4e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain HTH_Tnp_Tc3_2 PF01498.13 ESA12600.1 - 6.2e-08 32.5 0.8 9.5e-08 31.9 0.5 1.3 1 0 0 1 1 1 1 Transposase DUF3316 PF11777.3 ESA12600.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) WW PF00397.21 ESA12602.1 - 0.0036 17.1 2.0 0.014 15.2 0.1 2.3 2 0 0 2 2 2 1 WW domain DUF837 PF05769.6 ESA12603.1 - 8.9e-05 22.0 15.9 0.00015 21.3 10.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF837) Med30 PF11315.3 ESA12603.1 - 0.017 15.2 2.6 0.017 15.2 1.8 2.1 1 1 0 1 1 1 0 Mediator complex subunit 30 Nup88 PF10168.4 ESA12603.1 - 0.034 11.9 3.4 0.052 11.3 2.3 1.2 1 0 0 1 1 1 0 Nuclear pore component Phenol_Hydrox PF02332.13 ESA12603.1 - 0.094 11.9 1.3 0.13 11.4 0.9 1.3 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase DUF972 PF06156.8 ESA12603.1 - 0.76 10.1 15.5 4.4 7.6 2.5 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF972) MBOAT_2 PF13813.1 ESA12604.1 - 1.5e-15 56.9 0.5 1.5e-15 56.9 0.4 2.0 3 0 0 3 3 3 1 Membrane bound O-acyl transferase family Ceramidase PF05875.7 ESA12605.1 - 2.1e-52 177.8 7.7 2.6e-52 177.5 5.4 1.0 1 0 0 1 1 1 1 Ceramidase DUF2208 PF09973.4 ESA12605.1 - 0.44 9.7 3.3 0.23 10.6 0.5 1.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2208) BTP PF05232.7 ESA12605.1 - 1.8 8.3 7.1 3.9 7.2 0.0 3.1 3 0 0 3 3 3 0 Bacterial Transmembrane Pair family 2OG-FeII_Oxy_2 PF13532.1 ESA12606.1 - 5.2e-26 91.6 0.0 5.9e-26 91.5 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESA12606.1 - 8e-07 29.2 0.0 1.5e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CKAP2_C PF15297.1 ESA12607.1 - 6.7 5.4 9.0 0.21 10.3 1.1 1.9 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus DUF892 PF05974.7 ESA12609.1 - 0.0097 15.7 3.5 0.012 15.4 2.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF892) RP-C_C PF11800.3 ESA12609.1 - 0.015 15.0 1.8 0.021 14.5 1.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region zf-C2H2_4 PF13894.1 ESA12609.1 - 0.024 14.9 1.2 0.073 13.4 0.8 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Symplekin_C PF12295.3 ESA12609.1 - 0.026 14.4 0.5 0.034 14.0 0.3 1.2 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal CUT PF02376.10 ESA12609.1 - 0.03 14.1 0.1 0.075 12.8 0.0 1.7 2 0 0 2 2 2 0 CUT domain ALMT PF11744.3 ESA12609.1 - 0.067 11.8 1.4 0.082 11.5 1.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF883 PF05957.8 ESA12609.1 - 0.1 13.0 2.2 0.19 12.1 1.5 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) YlbD_coat PF14071.1 ESA12609.1 - 0.15 12.1 1.6 0.48 10.4 0.3 2.1 2 0 0 2 2 2 0 Putative coat protein DUF2072 PF09845.4 ESA12609.1 - 0.27 11.1 2.2 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) FlaC_arch PF05377.6 ESA12609.1 - 0.49 10.3 3.1 1.7 8.5 0.7 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TSC22 PF01166.13 ESA12609.1 - 0.5 10.3 3.4 0.59 10.1 0.6 2.5 2 1 1 3 3 3 0 TSC-22/dip/bun family Med4 PF10018.4 ESA12609.1 - 0.55 9.5 5.9 0.8 9.0 4.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Cortex-I_coil PF09304.5 ESA12609.1 - 0.93 9.5 6.0 1.4 8.9 2.5 2.2 1 1 1 2 2 2 0 Cortexillin I, coiled coil Fib_alpha PF08702.5 ESA12609.1 - 1.3 9.1 6.9 1.6 8.8 1.2 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.6 ESA12609.1 - 1.6 9.1 6.5 2.1 8.7 3.2 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TBPIP PF07106.8 ESA12609.1 - 1.6 8.2 6.3 2.3 7.7 3.8 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin PF00804.20 ESA12609.1 - 2.2 8.4 9.4 4 7.6 6.5 1.5 1 1 0 1 1 1 0 Syntaxin DUF4379 PF14311.1 ESA12612.1 - 0.0075 16.0 2.9 0.0075 16.0 2.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4379) DUF953 PF06110.6 ESA12612.1 - 0.0085 15.5 0.1 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Pox_A32 PF04665.7 ESA12612.1 - 0.042 13.1 1.0 0.059 12.6 0.7 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein ER-remodelling PF14755.1 ESA12614.1 - 0.74 9.8 4.2 3.3 7.7 1.4 2.2 1 1 1 2 2 2 0 Intracellular membrane remodeller DUF2283 PF10049.4 ESA12615.1 - 6.3e-06 25.9 1.9 6.3e-06 25.9 1.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2283) CP2 PF04516.10 ESA12616.1 - 5.6e-59 199.0 2.0 8.2e-59 198.5 1.4 1.3 1 0 0 1 1 1 1 CP2 transcription factor TFIIA PF03153.8 ESA12616.1 - 0.019 14.8 11.4 0.031 14.1 7.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.5 ESA12616.1 - 0.31 9.4 3.9 0.42 8.9 2.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Opy2 PF09463.5 ESA12617.1 - 0.0004 20.4 14.9 0.0004 20.4 10.3 1.9 1 1 1 2 2 2 1 Opy2 protein Peptidase_S49_N PF08496.5 ESA12618.1 - 0.87 9.3 2.9 0.98 9.1 2.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BolA PF01722.13 ESA12619.1 - 1.6e-15 56.7 0.0 1.8e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 BolA-like protein Fibrillarin PF01269.12 ESA12619.1 - 0.031 13.2 0.0 0.031 13.2 0.0 1.1 1 0 0 1 1 1 0 Fibrillarin ERGIC_N PF13850.1 ESA12620.1 - 5.4e-25 87.1 0.1 1.2e-24 86.1 0.1 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) COPIIcoated_ERV PF07970.7 ESA12620.1 - 5.7e-22 78.4 0.1 1e-21 77.6 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter Syntaxin PF00804.20 ESA12621.1 - 2.5e-17 62.9 3.8 2.5e-17 62.9 2.6 2.9 3 0 0 3 3 2 1 Syntaxin SNARE PF05739.14 ESA12621.1 - 1.9e-13 49.8 7.1 1.9e-13 49.8 4.9 3.2 3 1 0 3 3 3 1 SNARE domain MCPsignal PF00015.16 ESA12621.1 - 2.4e-05 23.9 14.0 0.001 18.6 3.9 2.2 2 0 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain EIF_2_alpha PF07541.7 ESA12621.1 - 0.014 15.1 1.0 0.048 13.3 0.7 1.9 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Toprim_2 PF13155.1 ESA12621.1 - 0.018 15.3 0.4 0.07 13.4 0.3 2.1 1 0 0 1 1 1 0 Toprim-like DUF4094 PF13334.1 ESA12621.1 - 0.023 15.0 0.4 0.023 15.0 0.3 3.4 1 1 2 4 4 4 0 Domain of unknown function (DUF4094) GRA6 PF05084.8 ESA12621.1 - 0.07 12.6 0.2 0.07 12.6 0.1 1.9 2 0 0 2 2 2 0 Granule antigen protein (GRA6) DUF912 PF06024.7 ESA12621.1 - 0.076 13.0 0.5 0.076 13.0 0.3 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ABC2_membrane_2 PF12679.2 ESA12621.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein ISG65-75 PF11727.3 ESA12621.1 - 0.32 10.0 16.3 0.38 9.7 1.4 2.7 1 1 2 3 3 3 0 Invariant surface glycoprotein MutS_III PF05192.13 ESA12621.1 - 0.33 10.7 8.0 0.83 9.3 0.3 2.2 1 1 1 2 2 2 0 MutS domain III DUF948 PF06103.6 ESA12621.1 - 0.42 10.5 10.8 10 6.0 0.1 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4064 PF13273.1 ESA12621.1 - 0.55 10.3 1.9 0.42 10.7 0.1 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF4064) Vac_Fusion PF02346.11 ESA12621.1 - 1 8.8 5.8 0.36 10.2 0.5 2.7 3 0 0 3 3 3 0 Chordopoxvirus fusion protein DUF1664 PF07889.7 ESA12621.1 - 2.4 7.9 13.9 0.27 11.0 1.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) SapB_1 PF05184.10 ESA12621.1 - 7.6 6.4 5.6 49 3.9 0.5 3.2 3 0 0 3 3 3 0 Saposin-like type B, region 1 BTB PF00651.26 ESA12622.1 - 9.4e-17 61.0 0.0 1.6e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA12622.1 - 1.3e-13 51.0 0.8 4.3e-13 49.4 0.5 1.9 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA12622.1 - 0.048 13.5 0.5 3.2 7.6 0.1 2.8 1 1 0 1 1 1 0 BTB And C-terminal Kelch DUF221 PF02714.10 ESA12623.1 - 8.1e-89 297.6 27.3 5.7e-88 294.8 18.9 2.2 1 1 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ESA12623.1 - 2.4e-37 127.9 1.0 2.4e-37 127.9 0.7 3.0 3 1 0 3 3 3 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ESA12623.1 - 4.7e-18 65.4 0.2 1e-17 64.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) C2 PF00168.25 ESA12624.1 - 1.3e-26 92.2 2.6 2.2e-15 56.2 0.1 3.5 3 0 0 3 3 3 2 C2 domain RNA12 PF10443.4 ESA12625.1 - 1.8e-07 30.0 2.5 7.5e-05 21.3 0.6 3.3 1 1 2 3 3 3 1 RNA12 protein Arch_ATPase PF01637.13 ESA12625.1 - 7.2e-07 29.1 1.1 7.2e-07 29.1 0.7 2.5 1 1 1 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 ESA12625.1 - 4.4e-05 23.6 0.0 0.00016 21.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA12625.1 - 0.00013 21.8 4.0 0.00039 20.3 0.6 2.9 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESA12625.1 - 0.00063 20.5 0.5 0.0051 17.6 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA12625.1 - 0.0015 18.6 0.9 0.0048 17.1 0.2 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA12625.1 - 0.0025 17.8 0.0 0.0072 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.12 ESA12625.1 - 0.0048 16.3 0.1 0.14 11.5 0.0 2.6 2 1 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.1 ESA12625.1 - 0.019 14.4 0.0 0.05 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA12625.1 - 0.07 13.4 1.3 0.22 11.8 0.0 2.2 1 1 0 2 2 2 0 ABC transporter SRP54 PF00448.17 ESA12625.1 - 0.081 12.3 0.2 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF3744 PF12558.3 ESA12625.1 - 0.083 13.3 0.5 0.71 10.3 0.1 2.7 2 1 0 2 2 2 0 ATP-binding cassette cobalt transporter PhoH PF02562.11 ESA12625.1 - 0.092 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein YvbH_ext PF11724.3 ESA12625.1 - 0.83 9.3 7.4 0.76 9.4 0.8 2.6 2 0 0 2 2 2 0 YvbH-like oligomerisation region LRR_4 PF12799.2 ESA12626.1 - 1e-43 146.2 70.9 4.5e-10 38.9 4.2 11.9 5 2 9 15 15 15 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA12626.1 - 2e-42 142.7 56.3 5.8e-11 41.9 5.2 10.3 5 2 6 12 12 12 9 Leucine rich repeat LRR_1 PF00560.28 ESA12626.1 - 2.2e-28 93.9 55.7 0.11 12.6 0.2 17.9 17 1 1 18 18 18 11 Leucine Rich Repeat LRR_7 PF13504.1 ESA12626.1 - 5.3e-18 61.9 44.6 0.34 11.3 0.1 15.5 15 0 0 15 15 15 5 Leucine rich repeat LRR_6 PF13516.1 ESA12626.1 - 8.4e-13 46.9 53.8 0.23 11.6 0.1 15.0 13 2 2 15 15 15 7 Leucine Rich repeat LRR_9 PF14580.1 ESA12626.1 - 1e-07 31.6 14.2 0.38 10.2 0.8 5.3 2 2 3 5 5 5 5 Leucine-rich repeat LRR_5 PF13306.1 ESA12626.1 - 0.00026 20.6 3.4 0.0021 17.7 0.0 3.1 3 1 0 3 3 3 1 Leucine rich repeats (6 copies) Ribosomal_L15e PF00827.12 ESA12627.1 - 1.9e-63 213.4 5.8 2.2e-63 213.2 4.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 Interferon PF00143.14 ESA12629.1 - 0.046 13.5 0.3 0.076 12.8 0.2 1.3 1 0 0 1 1 1 0 Interferon alpha/beta domain DUF4525 PF15027.1 ESA12629.1 - 0.069 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) Pkinase_Tyr PF07714.12 ESA12631.1 - 4.4e-07 29.2 0.0 4.8e-07 29.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12631.1 - 0.002 17.3 0.1 0.0024 17.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain MobB PF03205.9 ESA12631.1 - 0.12 12.0 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B WWE PF02825.15 ESA12631.1 - 0.15 11.5 0.8 0.26 10.7 0.5 1.4 1 0 0 1 1 1 0 WWE domain DUF2778 PF10908.3 ESA12632.1 - 0.14 12.3 0.2 0.18 11.9 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2778) TLD PF07534.11 ESA12633.1 - 1.3e-13 51.1 2.2 3.9e-13 49.5 1.2 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA12633.1 - 2.2e-05 24.2 0.7 0.0032 17.2 0.1 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch TLD PF07534.11 ESA12634.1 - 8.4e-09 35.5 0.3 2.4e-08 34.0 0.1 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA12634.1 - 3e-05 23.7 0.7 0.0023 17.7 0.2 2.9 2 1 2 4 4 4 2 BTB And C-terminal Kelch His_Phos_1 PF00300.17 ESA12635.1 - 3e-21 76.1 0.0 3.7e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.17 ESA12635.1 - 0.00028 20.3 0.0 0.00037 19.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Inhibitor_I24 PF10465.4 ESA12635.1 - 0.0029 17.3 0.1 0.0055 16.4 0.1 1.4 1 0 0 1 1 1 1 PinA peptidase inhibitor GAT PF03127.9 ESA12635.1 - 0.034 14.1 5.4 0.19 11.6 0.2 2.3 1 1 1 2 2 2 0 GAT domain NodZ PF05830.6 ESA12635.1 - 0.12 10.9 0.3 0.16 10.4 0.2 1.1 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) HMG_box PF00505.14 ESA12637.1 - 1.9e-07 31.2 0.3 2.9e-07 30.6 0.2 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12637.1 - 0.0095 16.2 0.3 0.014 15.7 0.2 1.2 1 0 0 1 1 1 1 HMG-box domain DUF2421 PF10334.4 ESA12639.1 - 4.8e-13 49.2 1.8 6e-12 45.6 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) FUSC_2 PF13515.1 ESA12639.1 - 0.0009 19.1 14.0 0.0009 19.1 9.7 3.0 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.3 ESA12639.1 - 0.22 10.1 24.6 0.0089 14.7 4.3 2.5 2 2 0 2 2 2 0 Aluminium activated malate transporter AATF-Che1 PF13339.1 ESA12640.1 - 0.15 12.2 9.6 0.28 11.3 3.7 2.0 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF1090 PF06476.7 ESA12640.1 - 0.5 10.0 10.0 1.3 8.6 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) SDA1 PF05285.7 ESA12640.1 - 2.1 7.5 22.1 2.7 7.1 15.3 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 ESA12640.1 - 2.3 6.0 26.5 2.6 5.8 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family Atg14 PF10186.4 ESA12640.1 - 3.4 6.5 9.6 0.45 9.4 2.9 1.9 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 BUD22 PF09073.5 ESA12640.1 - 3.7 6.5 22.6 4.5 6.2 15.6 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 ESA12640.1 - 8.3 4.3 20.2 9.8 4.0 14.0 1.1 1 0 0 1 1 1 0 CDC45-like protein F-box-like PF12937.2 ESA12642.1 - 6.3e-07 29.0 3.6 6.3e-07 29.0 2.5 1.5 2 0 0 2 2 2 1 F-box-like SMRP1 PF15181.1 ESA12642.1 - 0.098 12.0 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 PRANC PF09372.5 ESA12642.1 - 0.34 10.8 2.9 7.7 6.5 0.0 3.1 1 1 2 3 3 3 0 PRANC domain F-box PF00646.28 ESA12642.1 - 1.5 8.5 9.4 0.27 10.9 2.1 2.8 2 1 1 3 3 3 0 F-box domain THP2 PF09432.5 ESA12643.1 - 0.011 15.6 0.7 0.015 15.1 0.5 1.2 1 0 0 1 1 1 0 Tho complex subunit THP2 DUF924 PF06041.6 ESA12643.1 - 0.02 14.6 0.4 0.025 14.3 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF924) DUF4047 PF13256.1 ESA12643.1 - 0.064 13.2 3.0 0.1 12.5 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) YtxH PF12732.2 ESA12643.1 - 0.12 12.7 0.2 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 YtxH-like protein DUF3752 PF12572.3 ESA12643.1 - 1.6 8.8 6.5 1.9 8.5 4.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3752) Ribosomal_S4Pg PF11993.3 ESA12645.1 - 0.074 12.8 0.2 0.52 10.0 0.1 2.3 1 1 1 2 2 2 0 Ribosomal S4P (gammaproteobacterial) Ebola_NP PF05505.7 ESA12645.1 - 0.16 10.0 3.3 0.19 9.7 2.3 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Uma2 PF05685.7 ESA12646.1 - 9.1e-11 41.4 0.0 1.2e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease AAA_13 PF13166.1 ESA12647.1 - 0.0028 16.1 30.4 0.0028 16.1 21.1 4.0 1 1 3 4 4 4 1 AAA domain DUF4337 PF14235.1 ESA12647.1 - 0.053 13.3 0.1 0.053 13.3 0.0 5.7 5 1 0 6 6 6 0 Domain of unknown function (DUF4337) FtsH_ext PF06480.10 ESA12647.1 - 0.078 13.1 5.1 1.2 9.2 0.0 3.7 3 0 0 3 3 3 0 FtsH Extracellular Reo_sigmaC PF04582.7 ESA12647.1 - 4.5 6.3 15.1 1.9 7.5 0.1 4.2 2 1 4 6 6 6 0 Reovirus sigma C capsid protein DUF3186 PF11382.3 ESA12647.1 - 5 6.1 10.6 3.8 6.5 0.9 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3186) ILVD_EDD PF00920.16 ESA12648.1 - 9.9e-214 710.5 0.0 1.1e-213 710.3 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family DUF3112 PF11309.3 ESA12649.1 - 0.16 11.7 10.5 0.46 10.2 7.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) DUF3278 PF11683.3 ESA12649.1 - 0.28 11.1 9.3 0.9 9.5 0.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3278) DUF1129 PF06570.6 ESA12649.1 - 1.4 8.1 7.7 0.33 10.2 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Peptidase_S10 PF00450.17 ESA12650.1 - 0.011 14.9 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase F-box-like PF12937.2 ESA12652.1 - 0.00047 19.8 2.5 0.0014 18.3 1.7 1.9 1 0 0 1 1 1 1 F-box-like DUF1832 PF08870.6 ESA12653.1 - 0.072 12.8 0.9 3.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1832) Transposase_21 PF02992.9 ESA12654.1 - 1e-06 28.0 1.6 6.5e-05 22.1 0.1 2.4 1 1 1 2 2 2 2 Transposase family tnp2 ABC_tran PF00005.22 ESA12655.1 - 3e-34 118.2 0.0 8.6e-34 116.7 0.0 1.8 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.14 ESA12655.1 - 1.8e-06 27.3 1.2 0.00017 20.9 0.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA12655.1 - 4.5e-05 23.5 1.1 0.00043 20.3 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.1 ESA12655.1 - 0.0029 17.0 0.2 0.03 13.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA12655.1 - 0.0091 16.1 0.2 0.4 10.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.20 ESA12655.1 - 0.026 14.0 0.0 0.037 13.5 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.1 ESA12655.1 - 0.026 14.4 0.5 0.074 13.0 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.17 ESA12655.1 - 0.038 12.8 0.8 0.06 12.1 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.12 ESA12655.1 - 0.065 13.0 0.3 0.065 13.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 ESA12655.1 - 0.1 12.5 0.1 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.1 ESA12655.1 - 0.11 12.0 1.1 0.17 11.4 0.2 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_17 PF13207.1 ESA12655.1 - 0.16 12.8 1.8 0.52 11.1 1.2 2.1 1 1 0 1 1 1 0 AAA domain HMG_box PF00505.14 ESA12656.1 - 3.1e-09 36.9 0.8 5.5e-09 36.1 0.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF3810 PF12725.2 ESA12656.1 - 0.0069 15.3 1.3 0.014 14.3 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3810) Pkinase_Tyr PF07714.12 ESA12657.1 - 3.2e-41 141.1 0.1 4.1e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12657.1 - 3.5e-39 134.5 0.9 4.6e-39 134.1 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA12657.1 - 8e-05 21.7 0.1 0.00011 21.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA12657.1 - 0.01 14.7 0.0 0.012 14.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.17 ESA12657.1 - 0.029 13.7 0.3 0.051 12.9 0.2 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ESA12657.1 - 0.039 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DNA_pol3_a_NI PF14480.1 ESA12657.1 - 1.3 8.7 6.8 5.4 6.7 0.0 3.8 4 0 0 4 4 4 0 DNA polymerase III polC-type N-terminus I LRR_4 PF12799.2 ESA12658.1 - 0.035 13.7 0.8 0.99 9.0 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Caudo_TAP PF02413.12 ESA12658.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein LRR_6 PF13516.1 ESA12658.1 - 0.11 12.6 0.8 2.4 8.5 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.28 ESA12658.1 - 0.28 11.3 3.7 6 7.3 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat UBX PF00789.15 ESA12659.1 - 0.0046 16.9 0.0 0.0088 16.0 0.0 1.5 1 0 0 1 1 1 1 UBX domain Peptidase_M20 PF01546.23 ESA12661.1 - 3.4e-30 104.9 0.0 4.6e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESA12661.1 - 3e-15 55.9 0.0 4.9e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain tRNA-synt_1c PF00749.16 ESA12662.1 - 0.012 14.2 1.6 0.013 14.1 1.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Ax_dynein_light PF10211.4 ESA12662.1 - 0.48 10.2 6.9 0.51 10.1 4.8 1.0 1 0 0 1 1 1 0 Axonemal dynein light chain APG6 PF04111.7 ESA12662.1 - 0.57 9.1 5.3 0.55 9.2 3.7 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF972 PF06156.8 ESA12662.1 - 0.58 10.5 4.1 0.6 10.4 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_2 PF07716.10 ESA12662.1 - 0.61 9.9 6.3 0.29 11.0 2.5 1.9 1 1 1 2 2 2 0 Basic region leucine zipper Tom37_C PF11801.3 ESA12662.1 - 0.74 9.6 3.1 0.83 9.4 2.2 1.0 1 0 0 1 1 1 0 Tom37 C-terminal domain bZIP_1 PF00170.16 ESA12662.1 - 0.79 9.7 9.6 1 9.3 1.2 2.1 1 1 1 2 2 2 0 bZIP transcription factor GIT1_C PF12205.3 ESA12664.1 - 0.0019 18.0 0.1 0.0032 17.3 0.1 1.3 1 0 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term GATA PF00320.22 ESA12667.1 - 1.4e-09 37.0 13.4 1.4e-09 37.0 9.3 2.0 2 0 0 2 2 2 1 GATA zinc finger OSCP PF00213.13 ESA12668.1 - 4.7e-32 111.2 0.9 4.7e-32 111.2 0.6 1.4 2 0 0 2 2 2 1 ATP synthase delta (OSCP) subunit E2_bind PF08825.5 ESA12668.1 - 0.096 12.4 2.2 0.43 10.3 0.0 2.7 3 1 0 3 3 3 0 E2 binding domain Curlin_rpt PF07012.7 ESA12669.1 - 8.2 6.2 9.4 3.4 7.4 0.5 2.3 2 1 0 2 2 2 0 Curlin associated repeat Exo_endo_phos PF03372.18 ESA12670.1 - 3.5e-26 92.6 0.3 5.3e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.1 ESA12670.1 - 1.6e-12 46.9 29.7 4.6e-07 29.4 5.1 2.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESA12670.1 - 3.1e-11 42.6 17.0 6e-08 32.1 2.7 3.0 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA12670.1 - 5.3e-07 28.7 11.6 0.016 15.1 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA12670.1 - 0.038 14.1 9.8 2.9 8.4 0.1 4.8 4 0 0 4 4 4 0 Leucine rich repeat DUF2228 PF10228.4 ESA12671.1 - 0.011 15.3 1.5 0.011 15.3 1.1 1.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) DUF1707 PF08044.6 ESA12671.1 - 0.11 12.2 0.3 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) OEP PF02321.13 ESA12671.1 - 0.25 10.9 6.3 2 7.9 0.5 2.3 2 0 0 2 2 2 0 Outer membrane efflux protein CTP_transf_2 PF01467.21 ESA12672.1 - 2.1e-28 99.3 0.0 3.6e-13 49.8 0.0 2.3 2 0 0 2 2 2 2 Cytidylyltransferase FAD_syn PF06574.7 ESA12672.1 - 0.15 11.7 2.5 0.85 9.2 0.0 2.8 2 1 0 2 2 2 0 FAD synthetase Nucleoside_tran PF01733.13 ESA12673.1 - 0.18 10.9 2.2 0.34 10.0 1.5 1.4 1 0 0 1 1 1 0 Nucleoside transporter DUF2457 PF10446.4 ESA12673.1 - 0.32 9.6 15.8 0.79 8.3 10.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF506 PF04720.7 ESA12673.1 - 4.7 6.7 13.6 3 7.4 3.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF506) Lipase_3 PF01764.20 ESA12674.1 - 7.4e-32 109.8 0.0 1.1e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESA12674.1 - 0.039 13.8 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Collagen PF01391.13 ESA12674.1 - 0.063 12.8 2.0 0.13 11.8 1.4 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Torsin PF06309.6 ESA12674.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 Torsin Nucleo_P87 PF07267.6 ESA12675.1 - 0.04 12.6 0.4 0.044 12.4 0.3 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM176 PF14851.1 ESA12675.1 - 0.063 12.9 0.1 0.072 12.7 0.1 1.1 1 0 0 1 1 1 0 FAM176 family Dimer_Tnp_hAT PF05699.9 ESA12675.1 - 0.097 12.3 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 hAT family C-terminal dimerisation region Phage_GPO PF05929.6 ESA12679.1 - 1.7 7.8 6.6 1.9 7.6 4.6 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Pkinase_Tyr PF07714.12 ESA12680.1 - 9e-05 21.6 0.0 0.00015 20.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12680.1 - 0.013 14.6 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12681.1 - 5.3e-35 120.7 0.0 6.7e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12681.1 - 1.8e-28 99.4 0.0 2.6e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA12681.1 - 0.00053 19.3 0.1 0.003 16.9 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA12681.1 - 0.00096 18.9 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family BTK PF00779.14 ESA12688.1 - 0.018 14.6 3.0 0.018 14.6 2.1 4.2 4 1 1 5 5 5 0 BTK motif Lipase_3 PF01764.20 ESA12690.1 - 2.6e-34 117.8 0.0 3e-34 117.6 0.0 1.0 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.9 ESA12690.1 - 0.0016 17.7 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF2974 PF11187.3 ESA12690.1 - 0.002 17.5 0.0 0.016 14.5 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.2 ESA12690.1 - 0.0037 17.0 0.0 0.004 16.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA12690.1 - 0.0044 16.9 0.0 0.0044 16.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 ESA12690.1 - 0.069 13.3 0.0 0.098 12.8 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain DUF87 PF01935.12 ESA12694.1 - 0.012 15.5 0.6 0.014 15.1 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 AKNA PF12443.3 ESA12694.1 - 0.018 15.0 0.5 0.032 14.2 0.3 1.5 1 1 0 1 1 1 0 AT-hook-containing transcription factor DUF745 PF05335.8 ESA12694.1 - 0.021 14.3 0.6 0.027 13.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) FadA PF09403.5 ESA12694.1 - 0.081 12.9 7.3 0.78 9.7 1.5 2.2 1 1 1 2 2 2 0 Adhesion protein FadA SRP54_N PF02881.14 ESA12694.1 - 0.12 12.5 0.5 6.7 6.8 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain DUF919 PF06034.6 ESA12694.1 - 0.12 11.9 4.9 0.069 12.7 0.8 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF1694 PF07997.6 ESA12697.1 - 0.072 13.0 0.2 0.089 12.7 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1694) MULE PF10551.4 ESA12697.1 - 0.11 12.7 0.1 0.17 12.0 0.1 1.4 1 1 0 1 1 1 0 MULE transposase domain FAD_binding_1 PF00667.15 ESA12698.1 - 1.5e-62 210.8 0.0 2.6e-62 210.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.1 ESA12698.1 - 1.2e-18 67.1 0.0 5.7e-18 65.0 0.0 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding POR_N PF01855.14 ESA12698.1 - 1.8e-17 63.6 0.1 3.2e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg NAD_binding_1 PF00175.16 ESA12698.1 - 1.3e-12 48.2 0.1 6.7e-12 45.9 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Sirohm_synth_M PF14824.1 ESA12698.1 - 1.8e-05 23.5 0.1 6.3e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central PRD PF00874.15 ESA12698.1 - 0.048 13.7 2.8 0.22 11.6 0.5 3.1 3 0 0 3 3 3 0 PRD domain CDC37_C PF08564.5 ESA12698.1 - 0.074 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Cdc37 C terminal domain DDE_3 PF13358.1 ESA12699.1 - 3e-10 40.0 0.0 3.2e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease PAS_6 PF08348.6 ESA12699.1 - 0.074 12.6 0.0 0.092 12.3 0.0 1.1 1 0 0 1 1 1 0 YheO-like PAS domain DUF3646 PF12362.3 ESA12701.1 - 0.098 12.6 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal DIL PF01843.14 ESA12703.1 - 1.7e-22 79.2 7.9 3.5e-22 78.2 5.5 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.2 ESA12703.1 - 5.2e-19 68.3 0.2 1.1e-18 67.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 ESA12703.1 - 9.6e-16 56.7 1.1 2.8e-08 33.1 0.2 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESA12703.1 - 1.2e-14 53.9 0.3 3.2e-07 30.3 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESA12703.1 - 9e-13 48.3 0.0 0.00021 21.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA12703.1 - 2.2e-11 42.8 0.4 6.5e-05 22.7 0.1 4.2 3 0 0 3 3 3 2 Ankyrin repeat FAD_binding_6 PF00970.19 ESA12705.1 - 2.5e-10 40.3 0.0 4.7e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 ESA12705.1 - 7.8e-09 35.2 0.0 1.4e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cytochrom_B561 PF03188.11 ESA12705.1 - 0.00025 20.8 9.2 0.00071 19.4 6.4 1.8 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Rtf2 PF04641.7 ESA12705.1 - 0.066 12.3 0.8 0.091 11.9 0.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Tetraspannin PF00335.15 ESA12705.1 - 0.72 9.0 5.9 1.5 8.0 4.1 1.6 1 0 0 1 1 1 0 Tetraspanin family NAD_binding_1 PF00175.16 ESA12706.1 - 2.6e-15 56.9 0.0 1.1e-10 42.0 0.0 2.2 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA12706.1 - 1e-06 28.7 0.0 0.0016 18.3 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Pkinase_Tyr PF07714.12 ESA12707.1 - 1.7e-47 161.6 0.0 2.7e-47 161.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12707.1 - 1.5e-36 125.8 0.2 3e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA12707.1 - 1.3e-21 76.5 4.9 2.8e-06 27.7 0.1 4.4 4 0 0 4 4 4 4 Sel1 repeat DUF3679 PF12438.3 ESA12707.1 - 0.082 12.2 0.0 0.22 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3679) DUF1212 PF06738.7 ESA12710.1 - 0.066 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1212) Sulfotransfer_1 PF00685.22 ESA12710.1 - 0.18 11.0 1.1 0.23 10.7 0.7 1.4 1 1 0 1 1 1 0 Sulfotransferase domain TLD PF07534.11 ESA12711.1 - 1.9e-15 57.0 1.6 3e-15 56.4 1.1 1.3 1 0 0 1 1 1 1 TLD ACCA PF03255.9 ESA12712.1 - 0.12 11.9 0.1 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit F-box-like PF12937.2 ESA12713.1 - 0.00073 19.2 0.4 0.0018 17.9 0.3 1.6 1 0 0 1 1 1 1 F-box-like zf-C3HC4_2 PF13923.1 ESA12715.1 - 0.19 11.7 7.7 0.22 11.5 2.7 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA12715.1 - 0.29 10.8 9.6 0.12 12.1 3.5 2.5 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA12715.1 - 1.3 8.7 10.3 0.27 10.9 2.1 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA12715.1 - 3.2 7.6 11.7 2.7 7.8 4.3 3.1 3 0 0 3 3 3 0 Ring finger domain Pkinase_Tyr PF07714.12 ESA12719.1 - 2.2e-47 161.3 0.0 4.1e-47 160.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12719.1 - 3.6e-43 147.5 0.1 8.4e-43 146.3 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA12719.1 - 0.17 11.5 0.6 0.31 10.7 0.4 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NOB1_Zn_bind PF08772.6 ESA12720.1 - 0.035 13.9 0.2 0.091 12.5 0.1 1.7 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Pkinase_Tyr PF07714.12 ESA12722.1 - 0.00013 21.1 0.2 0.00014 21.0 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12722.1 - 0.00062 18.9 0.9 0.00064 18.9 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain FlpD PF02662.11 ESA12722.1 - 0.044 13.4 0.1 0.066 12.9 0.1 1.3 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit Ion_trans PF00520.26 ESA12723.1 - 9e-07 28.3 6.9 1.4e-06 27.7 4.8 1.2 1 0 0 1 1 1 1 Ion transport protein TPR_17 PF13431.1 ESA12723.1 - 1.4 9.2 3.3 5.1 7.5 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TRP PF06011.7 ESA12723.1 - 1.5 7.2 7.6 3.2 6.2 5.2 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel DnaJ PF00226.26 ESA12725.1 - 5e-07 29.3 0.3 5.8e-07 29.1 0.2 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 ESA12725.1 - 2.2e-06 27.4 0.2 2.4e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Pam16 WD40 PF00400.27 ESA12727.1 - 5.3e-15 54.6 4.3 0.00025 20.8 0.0 7.6 8 0 0 8 8 8 4 WD domain, G-beta repeat eIF2A PF08662.6 ESA12727.1 - 1.3e-11 44.5 6.8 0.00018 21.2 0.2 4.7 2 2 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 ESA12727.1 - 1.6e-07 29.6 3.3 3.6e-05 21.8 0.0 2.9 3 0 0 3 3 3 2 IKI3 family PD40 PF07676.7 ESA12727.1 - 0.0027 17.3 0.8 0.95 9.2 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF1513 PF07433.6 ESA12727.1 - 0.016 14.1 0.0 0.09 11.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) Lactonase PF10282.4 ESA12727.1 - 0.025 13.6 0.0 1.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller DPPIV_N PF00930.16 ESA12727.1 - 0.43 9.0 7.0 6.8 5.1 0.0 4.6 4 2 3 7 7 7 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pkinase_Tyr PF07714.12 ESA12728.1 - 0.00016 20.8 0.0 0.00027 20.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SMI1_KNR4 PF09346.5 ESA12728.1 - 0.035 14.1 0.5 0.042 13.8 0.4 1.2 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) DDE_Tnp_ISAZ013 PF07592.6 ESA12729.1 - 0.0086 14.8 0.1 0.013 14.3 0.1 1.2 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain DDE_1 PF03184.14 ESA12735.1 - 1.3e-16 60.3 6.3 5.1e-09 35.5 0.2 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF59 PF01883.14 ESA12737.1 - 0.07 13.1 0.0 0.084 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF59 DUF4097 PF13349.1 ESA12737.1 - 2.4 7.6 10.3 13 5.3 7.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4097) Methyltransf_23 PF13489.1 ESA12738.1 - 0.00014 21.5 0.0 0.00042 20.0 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA12738.1 - 0.0037 17.7 2.0 0.0052 17.2 0.0 2.4 3 2 0 3 3 3 1 Methyltransferase domain Methyltransf_28 PF02636.12 ESA12738.1 - 0.0082 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Arc PF03869.9 ESA12738.1 - 0.069 12.7 1.3 0.3 10.7 0.0 2.6 3 0 0 3 3 3 0 Arc-like DNA binding domain Acetyltransf_11 PF13720.1 ESA12739.1 - 0.01 16.0 0.1 0.046 13.9 0.0 2.1 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 HMG_box PF00505.14 ESA12739.1 - 0.064 13.5 5.1 0.067 13.4 1.1 2.4 2 0 0 2 2 2 0 HMG (high mobility group) box HAUS6_N PF14661.1 ESA12739.1 - 1 8.6 10.4 0.16 11.2 4.6 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus GvpK PF05121.7 ESA12739.1 - 1.1 9.1 4.1 0.48 10.2 0.5 2.2 2 1 0 2 2 2 0 Gas vesicle protein K Enkurin PF13864.1 ESA12739.1 - 1.5 9.0 8.5 18 5.6 0.1 3.1 3 0 0 3 3 3 0 Calmodulin-binding Rota_NSP4 PF01452.11 ESA12739.1 - 6.3 6.1 9.9 4.2 6.6 0.1 3.2 3 1 0 3 3 3 0 Rotavirus non structural protein E1-E2_ATPase PF00122.15 ESA12740.1 - 3.5e-50 170.2 0.0 3.5e-50 170.2 0.0 2.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA12740.1 - 2.3e-16 59.8 8.9 2.3e-16 59.8 6.2 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA12740.1 - 2.4e-16 60.8 0.7 3.4e-15 57.0 0.5 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA12740.1 - 9.7e-16 58.4 0.0 1.8e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA12740.1 - 3.8e-09 36.3 0.0 9.2e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 ESA12740.1 - 4.7e-08 32.3 0.0 1.2e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESA12740.1 - 0.0041 16.7 0.1 0.085 12.4 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Viral_cys_rich PF08008.7 ESA12742.1 - 0.46 10.0 5.3 2.4 7.7 0.5 3.0 2 1 1 3 3 3 0 Viral cysteine rich Abhydrolase_6 PF12697.2 ESA12744.1 - 2.3e-16 60.4 0.0 4.7e-16 59.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA12744.1 - 3.9e-11 42.9 0.0 1.8e-10 40.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA12744.1 - 4.4e-09 36.2 0.0 2e-08 34.1 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 ESA12744.1 - 0.00038 19.9 0.0 0.00084 18.8 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 ESA12744.1 - 0.0011 18.5 0.0 1.6 8.1 0.0 3.0 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DUF900 PF05990.7 ESA12744.1 - 0.0012 18.2 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.10 ESA12744.1 - 0.0093 14.9 0.0 0.016 14.1 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF953 PF06110.6 ESA12744.1 - 0.054 12.9 0.0 1.9 7.9 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Pkinase_Tyr PF07714.12 ESA12744.1 - 0.061 12.3 0.1 0.084 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Cutinase PF01083.17 ESA12744.1 - 0.069 12.8 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Cutinase SEN1_N PF12726.2 ESA12745.1 - 0.01 13.9 0.2 0.01 13.9 0.2 1.0 1 0 0 1 1 1 0 SEN1 N terminal Rad60-SLD PF11976.3 ESA12745.1 - 0.041 13.5 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Tektin PF03148.9 ESA12745.1 - 0.081 11.4 2.0 0.082 11.4 0.5 1.5 2 0 0 2 2 2 0 Tektin family HTH_Tnp_Tc5 PF03221.11 ESA12748.1 - 2.4e-08 33.6 0.1 3.5e-08 33.1 0.1 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain RNase_H PF00075.19 ESA12751.1 - 4.1e-21 75.7 0.0 7e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.1 ESA12751.1 - 0.46 10.8 0.1 0.46 10.8 0.1 2.7 3 0 0 3 3 3 0 zinc-binding in reverse transcriptase RhaT PF06379.7 ESA12753.1 - 0.92 8.4 9.6 0.85 8.5 0.7 2.1 1 1 1 2 2 2 0 L-rhamnose-proton symport protein (RhaT) zf-GRF PF06839.7 ESA12757.1 - 1.1e-09 38.0 5.0 2.5e-09 36.9 3.5 1.6 1 0 0 1 1 1 1 GRF zinc finger CENP-F_leu_zip PF10473.4 ESA12757.1 - 0.006 16.4 10.1 0.012 15.4 7.0 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1875 PF08961.5 ESA12757.1 - 0.053 12.8 3.6 0.097 11.9 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) bZIP_Maf PF03131.12 ESA12757.1 - 1.2 9.5 9.6 0.14 12.5 1.8 2.6 2 1 1 3 3 3 0 bZIP Maf transcription factor APG6 PF04111.7 ESA12757.1 - 1.3 8.0 9.7 1.9 7.4 6.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 SNARE PF05739.14 ESA12759.1 - 0.045 13.4 2.2 0.084 12.5 0.5 2.2 2 0 0 2 2 2 0 SNARE domain RRM_5 PF13893.1 ESA12759.1 - 0.046 13.5 0.1 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA12759.1 - 0.12 12.3 3.6 0.28 11.1 2.5 1.7 1 0 0 1 1 1 0 Zinc knuckle SynMuv_product PF06047.6 ESA12760.1 - 0.018 14.7 0.7 0.018 14.7 0.5 1.6 2 0 0 2 2 2 0 Ras-induced vulval development antagonist GcpE PF04551.9 ESA12760.1 - 0.035 12.9 0.3 0.042 12.6 0.2 1.1 1 0 0 1 1 1 0 GcpE protein IL3 PF02059.10 ESA12760.1 - 2 8.4 5.5 1.8 8.5 0.5 2.2 2 0 0 2 2 2 0 Interleukin-3 Lzipper-MIP1 PF14389.1 ESA12761.1 - 0.012 15.7 5.6 0.16 12.0 1.3 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF4515 PF14988.1 ESA12761.1 - 0.012 15.2 6.8 0.017 14.8 4.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4515) HalX PF08663.5 ESA12761.1 - 0.033 14.1 2.4 20 5.2 0.0 3.9 3 2 2 5 5 5 0 HalX domain NPV_P10 PF05531.7 ESA12761.1 - 0.079 13.2 2.9 0.27 11.4 0.6 2.8 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein LURAP PF14854.1 ESA12761.1 - 0.09 12.4 3.1 0.87 9.3 0.2 3.1 2 1 1 3 3 3 0 Leucine rich adaptor protein FemAB PF02388.11 ESA12761.1 - 0.12 11.0 7.9 1.7 7.2 0.1 2.1 2 0 0 2 2 2 0 FemAB family Tropomyosin_1 PF12718.2 ESA12761.1 - 0.13 12.1 8.8 0.91 9.3 1.5 2.6 1 1 0 2 2 2 0 Tropomyosin like DUF3573 PF12097.3 ESA12761.1 - 0.18 10.4 8.4 0.1 11.2 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) FlxA PF14282.1 ESA12761.1 - 0.19 11.7 19.5 0.026 14.4 6.2 3.2 1 1 2 3 3 3 0 FlxA-like protein Dynamitin PF04912.9 ESA12761.1 - 0.25 10.1 9.7 0.36 9.5 1.1 3.0 2 1 1 3 3 3 0 Dynamitin Spc42p PF11544.3 ESA12761.1 - 0.69 9.8 7.9 4.8 7.1 0.9 3.3 2 1 1 3 3 2 0 Spindle pole body component Spc42p EAP30 PF04157.11 ESA12761.1 - 1 8.4 7.9 4.8 6.2 0.4 2.8 2 1 0 2 2 2 0 EAP30/Vps36 family HR1 PF02185.11 ESA12761.1 - 1.7 8.4 7.5 3.4 7.4 0.4 3.2 2 1 1 3 3 3 0 Hr1 repeat ADIP PF11559.3 ESA12761.1 - 2.2 8.1 11.5 0.12 12.2 3.3 2.3 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding COG2 PF06148.6 ESA12761.1 - 2.2 8.1 6.5 0.52 10.1 1.1 2.4 4 0 0 4 4 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Syntaxin PF00804.20 ESA12761.1 - 2.3 8.4 10.2 3.4 7.9 2.7 2.6 2 1 0 2 2 2 0 Syntaxin Mnd1 PF03962.10 ESA12761.1 - 2.3 7.8 9.9 0.18 11.4 1.4 2.3 1 1 1 2 2 2 0 Mnd1 family Occludin_ELL PF07303.8 ESA12761.1 - 2.3 8.9 7.1 7.1 7.4 0.5 3.6 1 1 2 4 4 4 0 Occludin homology domain Fez1 PF06818.10 ESA12761.1 - 2.6 8.0 8.7 3.1 7.7 5.4 1.5 1 1 0 1 1 1 0 Fez1 DUF4094 PF13334.1 ESA12761.1 - 3.3 8.1 9.3 42 4.6 0.1 4.2 1 1 3 5 5 5 0 Domain of unknown function (DUF4094) Enkurin PF13864.1 ESA12761.1 - 4.1 7.6 10.4 23 5.2 0.6 3.9 3 1 0 3 3 3 0 Calmodulin-binding DUF1690 PF07956.6 ESA12761.1 - 5 7.0 14.6 9.1 6.2 0.5 3.4 1 1 3 4 4 4 0 Protein of Unknown function (DUF1690) Fib_alpha PF08702.5 ESA12761.1 - 5.1 7.2 9.6 1.3e+02 2.6 4.8 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family AATF-Che1 PF13339.1 ESA12761.1 - 6.4 6.9 9.5 1.7e+02 2.3 6.6 2.8 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF4391 PF14335.1 ESA12761.1 - 7.3 5.9 11.6 4.9 6.4 3.3 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4391) TLD PF07534.11 ESA12762.1 - 2.1e-13 50.4 0.0 2.4e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 TLD DUF4206 PF13901.1 ESA12763.1 - 0.39 10.2 2.7 0.56 9.7 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4206) GluR_Homer-bdg PF10606.4 ESA12763.1 - 0.63 9.9 2.4 1.6 8.6 1.7 1.7 1 0 0 1 1 1 0 Homer-binding domain of metabotropic glutamate receptor E1-E2_ATPase PF00122.15 ESA12766.1 - 2.1e-59 200.3 2.2 2.1e-59 200.3 1.5 1.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 ESA12766.1 - 3.5e-22 78.1 0.0 6.7e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 ESA12766.1 - 9.4e-22 78.4 0.0 3.4e-21 76.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA12766.1 - 1.4e-15 56.5 0.0 3.1e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESA12766.1 - 1.3e-10 41.8 0.0 2.4e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4231 PF14015.1 ESA12766.1 - 1.4 8.9 6.6 0.63 10.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) CPSase_L_D3 PF02787.14 ESA12768.1 - 0.098 12.4 0.4 0.11 12.2 0.2 1.1 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain F-box-like PF12937.2 ESA12770.1 - 0.00049 19.7 0.6 0.00049 19.7 0.4 1.7 2 0 0 2 2 2 1 F-box-like DDE_1 PF03184.14 ESA12771.1 - 4.8e-13 48.7 0.1 8.9e-12 44.6 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA12771.1 - 0.00065 19.4 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Got1 PF04178.7 ESA12773.1 - 1.5e-10 41.2 7.8 1.8e-10 40.9 5.4 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family PGG PF13962.1 ESA12773.1 - 0.057 13.0 1.0 0.09 12.3 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF2207 PF09972.4 ESA12773.1 - 0.066 11.7 1.3 0.076 11.5 0.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pam17 PF08566.5 ESA12773.1 - 0.15 11.7 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 SdpI PF13630.1 ESA12773.1 - 0.47 10.1 4.2 0.67 9.7 2.9 1.3 1 0 0 1 1 1 0 SdpI/YhfL protein family DUF4064 PF13273.1 ESA12773.1 - 0.87 9.7 7.8 1.2 9.2 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) YqzM PF14141.1 ESA12773.1 - 2 8.2 13.5 0.49 10.2 0.2 2.7 1 1 2 3 3 3 0 YqzM-like protein zf-CHCC PF10276.4 ESA12774.1 - 1.2e-15 57.0 2.0 1.7e-15 56.5 1.4 1.2 1 0 0 1 1 1 1 Zinc-finger domain LIM_bind PF01803.11 ESA12776.1 - 0.14 11.2 3.4 0.17 10.9 2.4 1.1 1 0 0 1 1 1 0 LIM-domain binding protein F-box-like PF12937.2 ESA12779.1 - 2.4e-05 23.9 0.5 5.6e-05 22.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like adh_short PF00106.20 ESA12780.1 - 9.4e-07 28.8 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase PMT PF02366.13 ESA12782.1 - 1.8e-74 250.2 17.0 1.8e-74 250.2 11.8 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 ESA12782.1 - 1.1e-49 168.5 0.4 3.1e-49 167.1 0.3 1.8 1 0 0 1 1 1 1 MIR domain XPG_N PF00752.12 ESA12782.1 - 0.049 13.8 0.0 0.45 10.7 0.0 2.3 2 0 0 2 2 2 0 XPG N-terminal domain MIF PF01187.13 ESA12783.1 - 2.1e-10 40.6 0.0 2.4e-10 40.4 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) DUF3243 PF11588.3 ESA12783.1 - 0.047 13.6 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) PIF1 PF05970.9 ESA12784.1 - 7.1e-39 133.7 0.1 1.1e-38 133.1 0.1 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 ESA12784.1 - 0.00074 19.1 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA12784.1 - 0.0012 17.8 0.0 0.0016 17.4 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein Arch_ATPase PF01637.13 ESA12784.1 - 0.0027 17.4 0.0 0.006 16.3 0.0 1.5 2 0 0 2 2 2 1 Archaeal ATPase AAA_19 PF13245.1 ESA12784.1 - 0.0035 17.0 0.2 0.0067 16.1 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 ESA12784.1 - 0.0065 16.3 0.2 0.016 15.0 0.1 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 ESA12784.1 - 0.0067 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein RNA_binding PF01877.12 ESA12784.1 - 0.0072 16.3 0.3 0.013 15.5 0.2 1.3 1 0 0 1 1 1 1 RNA binding AAA_16 PF13191.1 ESA12784.1 - 0.0097 15.9 0.0 0.023 14.7 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain XFP_N PF09364.5 ESA12784.1 - 0.013 14.0 0.0 0.019 13.5 0.0 1.2 1 0 0 1 1 1 0 XFP N-terminal domain DUF2791 PF10923.3 ESA12784.1 - 0.033 12.8 0.0 0.045 12.3 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.1 ESA12784.1 - 0.058 13.5 0.0 0.25 11.4 0.0 1.9 1 1 0 2 2 2 0 AAA domain DUF258 PF03193.11 ESA12784.1 - 0.058 12.5 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF3465 PF11948.3 ESA12784.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3465) DUF2075 PF09848.4 ESA12784.1 - 0.072 12.0 0.1 0.12 11.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 ESA12784.1 - 0.079 12.6 0.1 10 5.7 0.0 2.2 2 0 0 2 2 2 0 NACHT domain TrwB_AAD_bind PF10412.4 ESA12784.1 - 0.1 11.1 0.0 0.17 10.4 0.0 1.4 1 1 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Helitron_like_N PF14214.1 ESA12785.1 - 2.9e-16 59.7 1.2 1.3e-08 34.8 0.0 2.3 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus E1-E2_ATPase PF00122.15 ESA12786.1 - 9.5e-61 204.7 1.7 9.5e-61 204.7 1.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 ESA12786.1 - 1.4e-21 76.1 0.0 3.1e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 ESA12786.1 - 6.4e-21 75.7 0.0 3.7e-20 73.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA12786.1 - 2.1e-14 52.7 0.0 4.6e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 ESA12786.1 - 8.1e-10 39.1 0.0 1.5e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pneumo_att_G PF05539.6 ESA12786.1 - 0.22 10.8 21.2 0.41 9.9 14.7 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF4231 PF14015.1 ESA12786.1 - 2.7 8.0 5.7 2 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Pox_TAA1 PF03295.9 ESA12789.1 - 0.02 14.5 0.5 0.37 10.4 0.1 2.3 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal DUF2443 PF10398.4 ESA12789.1 - 0.095 12.5 0.8 1.6 8.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) ubiquitin PF00240.18 ESA12791.1 - 1.4e-108 354.3 33.2 7.5e-29 98.9 0.6 7.4 5 1 2 7 7 7 6 Ubiquitin family Rad60-SLD PF11976.3 ESA12791.1 - 4.6e-52 173.6 24.9 1.7e-13 50.0 0.6 6.9 6 1 1 7 7 7 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA12791.1 - 6.2e-17 61.6 21.6 0.00058 20.0 0.1 7.6 4 2 2 6 6 6 5 Ubiquitin-like domain ZZ PF00569.12 ESA12791.1 - 8.9e-10 37.9 5.2 1.7e-09 37.0 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF2407 PF10302.4 ESA12791.1 - 0.00021 21.3 5.9 6.2 7.0 0.1 5.3 4 1 0 4 4 4 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA12791.1 - 0.0019 18.0 0.7 0.71 9.7 0.0 3.6 3 1 1 4 4 4 1 Ubiquitin-2 like Rad60 SUMO-like Telomere_Sde2 PF13019.1 ESA12791.1 - 0.005 16.5 0.6 0.94 9.1 0.0 3.9 4 0 0 4 4 4 1 Telomere stability and silencing DUF1275 PF06912.6 ESA12791.1 - 0.013 14.7 0.5 0.02 14.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) C1_3 PF07649.7 ESA12791.1 - 0.019 14.9 6.8 0.037 14.0 4.7 1.5 1 0 0 1 1 1 0 C1-like domain Big_1 PF02369.11 ESA12791.1 - 0.033 14.0 0.1 3.9 7.4 0.0 3.3 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) TPR_14 PF13428.1 ESA12791.1 - 0.096 13.3 0.0 0.19 12.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Tnp_zf-ribbon_2 PF13842.1 ESA12791.1 - 3.5 8.1 5.6 8.3 6.9 3.9 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Sdh_cyt PF01127.17 ESA12792.1 - 5e-22 77.9 0.7 6.5e-22 77.6 0.5 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit p450 PF00067.17 ESA12796.1 - 6.8e-85 285.3 0.1 8.7e-85 284.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 XendoU PF09412.5 ESA12796.1 - 0.012 14.6 0.4 0.017 14.1 0.3 1.2 1 0 0 1 1 1 0 Endoribonuclease XendoU CtIP_N PF10482.4 ESA12796.1 - 0.37 10.5 3.0 0.71 9.6 2.1 1.4 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain ChuX_HutX PF06228.8 ESA12797.1 - 0.045 13.1 0.1 0.14 11.5 0.0 1.9 2 1 0 2 2 2 0 Haem utilisation ChuX/HutX Hepcidin PF06446.7 ESA12797.1 - 0.14 12.5 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Hepcidin F-box-like PF12937.2 ESA12798.1 - 0.00018 21.1 6.9 0.00064 19.4 1.9 3.0 3 0 0 3 3 3 2 F-box-like zf-BED PF02892.10 ESA12803.1 - 0.012 15.3 3.4 0.03 14.0 2.4 1.7 1 0 0 1 1 1 0 BED zinc finger PyrI_C PF02748.10 ESA12803.1 - 0.018 14.4 0.7 0.049 13.0 0.5 1.8 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain FAST_2 PF08368.7 ESA12804.1 - 0.046 14.1 0.1 11 6.4 0.0 2.6 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 2 DUF1015 PF06245.6 ESA12807.1 - 0.052 12.0 0.2 0.1 11.0 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1015) Lebercilin PF15619.1 ESA12808.1 - 0.005 16.2 5.5 0.0072 15.7 3.8 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF2278 PF10042.4 ESA12809.1 - 0.014 15.1 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) Pkinase PF00069.20 ESA12812.1 - 1.5e-37 129.1 0.0 1.8e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12812.1 - 5e-34 117.5 0.0 5.8e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA12812.1 - 0.00052 19.0 0.0 0.00077 18.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA12812.1 - 0.0085 15.4 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA12812.1 - 0.012 15.3 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA12812.1 - 0.024 14.1 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 ESA12812.1 - 0.024 13.6 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA12814.1 - 7.8e-12 44.8 0.0 1.2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12814.1 - 2.6e-05 23.4 0.0 4.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA12814.1 - 0.003 17.3 0.1 0.016 14.9 0.2 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA12814.1 - 0.14 11.1 0.0 0.32 10.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FNIP PF05725.7 ESA12817.1 - 0.078 12.9 12.0 0.67 9.9 0.0 5.0 6 2 0 6 6 6 0 FNIP Repeat Nodulin_late PF07127.6 ESA12818.1 - 0.82 9.8 3.2 1.1 9.4 0.8 2.1 1 1 1 2 2 2 0 Late nodulin protein Pkinase_Tyr PF07714.12 ESA12824.1 - 5.4e-20 71.5 0.2 6.3e-20 71.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12824.1 - 2.7e-19 69.3 0.5 3.5e-19 68.9 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain SMN PF06003.7 ESA12825.1 - 0.038 13.1 6.1 0.043 12.9 4.2 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF3408 PF11888.3 ESA12825.1 - 0.081 12.8 12.4 0.1 12.5 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Z1 PF10593.4 ESA12825.1 - 0.14 11.3 10.9 0.16 11.1 7.6 1.0 1 0 0 1 1 1 0 Z1 domain Bud13 PF09736.4 ESA12825.1 - 0.17 12.1 15.2 0.18 12.0 10.5 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Mcm10 PF09332.6 ESA12825.1 - 0.24 10.7 12.6 0.31 10.3 8.7 1.2 1 0 0 1 1 1 0 Mcm10 replication factor Serinc PF03348.10 ESA12825.1 - 0.47 9.0 11.5 0.47 9.0 7.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RED_N PF07808.8 ESA12825.1 - 0.48 9.5 18.7 0.53 9.4 13.0 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region Dala_Dala_lig_N PF01820.16 ESA12825.1 - 0.57 10.5 5.3 0.64 10.3 3.7 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus Neur_chan_memb PF02932.11 ESA12825.1 - 0.64 9.8 11.3 0.72 9.6 7.8 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1764 PF08576.5 ESA12825.1 - 0.75 10.6 13.0 0.97 10.2 9.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) BCS1_N PF08740.6 ESA12825.1 - 0.92 9.0 11.1 1.2 8.6 7.7 1.1 1 0 0 1 1 1 0 BCS1 N terminal DUF2828 PF11443.3 ESA12825.1 - 0.94 7.6 8.5 1 7.5 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Glyco_transf_6 PF03414.8 ESA12825.1 - 1.2 7.4 7.9 1.4 7.3 5.5 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 6 Plasmodium_Vir PF05795.6 ESA12825.1 - 1.3 8.1 6.9 1.4 8.0 4.8 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein FAM176 PF14851.1 ESA12825.1 - 1.4 8.5 5.0 1.6 8.4 3.5 1.1 1 0 0 1 1 1 0 FAM176 family FAM60A PF15396.1 ESA12825.1 - 1.5 8.5 10.0 1.7 8.3 6.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Prog_receptor PF02161.10 ESA12825.1 - 2.1 7.0 10.9 2.5 6.8 7.6 1.0 1 0 0 1 1 1 0 Progesterone receptor MMPL PF03176.10 ESA12825.1 - 2.1 6.9 7.1 2.4 6.8 4.9 1.0 1 0 0 1 1 1 0 MMPL family Kei1 PF08552.6 ESA12825.1 - 2.2 7.8 8.8 2.3 7.8 6.1 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SAGA-Tad1 PF12767.2 ESA12825.1 - 2.3 7.7 16.8 2.7 7.6 11.7 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Band_3_cyto PF07565.8 ESA12825.1 - 2.9 7.3 15.3 3.2 7.2 10.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MCPVI PF02993.9 ESA12825.1 - 3.2 7.8 13.2 3.9 7.5 9.2 1.1 1 0 0 1 1 1 0 Minor capsid protein VI Hid1 PF12722.2 ESA12825.1 - 3.2 5.2 19.8 3.7 5.1 13.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.7 ESA12825.1 - 3.3 7.5 11.3 3.4 7.4 7.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.1 ESA12825.1 - 3.3 6.8 15.6 3.7 6.6 10.8 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF1266 PF06889.6 ESA12825.1 - 3.3 7.4 9.8 4.3 7.1 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) G-7-MTase PF12803.2 ESA12825.1 - 3.4 6.7 9.8 3.5 6.6 6.8 1.0 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Mgr1 PF08602.5 ESA12825.1 - 3.4 6.5 9.4 3.6 6.5 6.5 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Gti1_Pac2 PF09729.4 ESA12825.1 - 3.6 7.4 9.2 3.9 7.3 6.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4557 PF15101.1 ESA12825.1 - 3.8 7.3 25.6 4.3 7.1 17.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) FLO_LFY PF01698.11 ESA12825.1 - 4 6.1 11.0 4.6 5.9 7.6 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein Mem_trans PF03547.13 ESA12825.1 - 4.3 5.5 7.4 4.4 5.4 5.1 1.0 1 0 0 1 1 1 0 Membrane transport protein BPL_N PF09825.4 ESA12825.1 - 4.4 6.0 7.6 4.5 5.9 5.3 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Zip PF02535.17 ESA12825.1 - 4.4 6.2 5.3 4.9 6.0 3.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CagX PF03524.10 ESA12825.1 - 4.6 6.4 13.5 5.6 6.1 9.4 1.2 1 0 0 1 1 1 0 Conjugal transfer protein Peptidase_S15 PF02129.13 ESA12825.1 - 4.7 6.5 12.3 4.7 6.5 8.6 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Otopetrin PF03189.8 ESA12825.1 - 4.7 6.0 6.4 5.1 5.9 4.5 1.0 1 0 0 1 1 1 0 Otopetrin DUF3513 PF12026.3 ESA12825.1 - 4.8 6.6 21.2 5.3 6.5 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) DUF4175 PF13779.1 ESA12825.1 - 5.1 4.6 43.1 4.9 4.7 29.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PMSI1 PF15322.1 ESA12825.1 - 5.2 6.0 10.9 5.8 5.8 7.6 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative AUX_IAA PF02309.11 ESA12825.1 - 5.3 6.7 12.1 5.9 6.5 8.4 1.1 1 0 0 1 1 1 0 AUX/IAA family SID-1_RNA_chan PF13965.1 ESA12825.1 - 5.3 5.0 8.1 5.2 5.1 5.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4638 PF15472.1 ESA12825.1 - 5.7 6.4 10.3 6.1 6.3 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) GPCR_chapero_1 PF11904.3 ESA12825.1 - 5.8 5.9 13.2 6 5.9 9.1 1.0 1 0 0 1 1 1 0 GPCR-chaperone CLPTM1 PF05602.7 ESA12825.1 - 5.8 5.5 12.6 6.5 5.3 8.7 1.0 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF4045 PF13254.1 ESA12825.1 - 5.8 6.0 13.9 6.9 5.8 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) eIF-3_zeta PF05091.7 ESA12825.1 - 6 5.3 18.1 6.2 5.3 12.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Auxin_canalis PF05703.6 ESA12825.1 - 6.9 6.4 6.6 7.3 6.3 4.6 1.0 1 0 0 1 1 1 0 Auxin canalisation Tim54 PF11711.3 ESA12825.1 - 7 5.1 12.2 7.6 5.0 8.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Peptidase_S49_N PF08496.5 ESA12825.1 - 7.6 6.3 13.1 9.4 6.0 9.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TT_ORF1 PF02956.9 ESA12825.1 - 7.6 4.8 18.5 9 4.6 12.8 1.0 1 0 0 1 1 1 0 TT viral orf 1 Glyco_transf_15 PF01793.11 ESA12825.1 - 7.6 5.3 12.6 8.3 5.2 8.7 1.1 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase IncA PF04156.9 ESA12825.1 - 7.9 6.0 26.4 8.6 5.8 18.3 1.1 1 0 0 1 1 1 0 IncA protein Baculo_PP31 PF05311.6 ESA12825.1 - 8 5.6 14.2 11 5.2 9.8 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) ARF7EP_C PF14949.1 ESA12825.1 - 8.1 6.9 13.9 11 6.4 9.7 1.2 1 0 0 1 1 1 0 ARF7 effector protein C-terminus DUF2215 PF10225.4 ESA12825.1 - 8.3 5.7 14.0 9.2 5.6 9.7 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2215) SprA-related PF12118.3 ESA12825.1 - 8.6 5.5 31.6 9.2 5.4 21.9 1.2 1 0 0 1 1 1 0 SprA-related family Het-C PF07217.6 ESA12825.1 - 9.5 4.2 10.4 10 4.1 7.2 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C AIF_C PF14721.1 ESA12825.1 - 9.8 6.4 12.5 13 6.0 8.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Folate_carrier PF01770.13 ESA12825.1 - 9.8 4.5 9.5 11 4.3 6.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier FrhB_FdhB_C PF04432.8 ESA12826.1 - 0.1 11.9 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus GATA PF00320.22 ESA12827.1 - 3.1e-16 58.4 2.9 3.1e-16 58.4 2.0 1.9 2 0 0 2 2 2 1 GATA zinc finger HTH_28 PF13518.1 ESA12832.1 - 7e-07 29.1 0.1 8.3e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA12832.1 - 5.2e-05 22.7 0.0 6.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA12832.1 - 0.00015 21.8 0.0 0.00016 21.7 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.1 ESA12832.1 - 0.001 18.6 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain CENP-B_N PF04218.8 ESA12832.1 - 0.015 14.7 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain PAX PF00292.13 ESA12832.1 - 0.022 14.4 0.0 0.024 14.3 0.0 1.0 1 0 0 1 1 1 0 'Paired box' domain HTH_Tnp_IS630 PF01710.11 ESA12832.1 - 0.023 14.3 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Transposase HTH_32 PF13565.1 ESA12832.1 - 0.023 15.4 0.1 0.036 14.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain LZ_Tnp_IS481 PF13011.1 ESA12832.1 - 0.074 13.4 0.0 0.082 13.2 0.0 1.1 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 HTH_27 PF13463.1 ESA12832.1 - 0.085 13.1 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain zf-C2H2 PF00096.21 ESA12834.1 - 4.7e-15 54.9 18.2 1.7e-05 24.8 1.1 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA12834.1 - 5.7e-13 48.2 16.5 0.00011 22.2 0.8 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA12834.1 - 3.1e-11 42.9 13.6 2.1e-06 27.7 0.6 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESA12834.1 - 7.8e-08 32.2 7.7 0.034 14.2 0.2 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA12834.1 - 1.6e-05 24.9 6.1 0.19 11.9 0.2 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type RRN7 PF11781.3 ESA12834.1 - 0.0055 16.1 4.3 1.6 8.3 0.0 3.1 3 0 0 3 3 3 1 RNA polymerase I-specific transcription initiation factor Rrn7 Zn-ribbon_8 PF09723.5 ESA12834.1 - 0.012 15.5 7.1 1.6 8.7 0.1 3.2 2 1 0 2 2 2 0 Zinc ribbon domain zf-C2H2_6 PF13912.1 ESA12834.1 - 0.012 15.4 7.3 0.53 10.2 0.0 3.4 3 1 0 3 3 3 0 C2H2-type zinc finger ADK_lid PF05191.9 ESA12834.1 - 0.012 15.2 0.4 0.012 15.2 0.3 2.9 3 0 0 3 3 3 0 Adenylate kinase, active site lid Prok-RING_1 PF14446.1 ESA12834.1 - 0.016 14.9 3.5 2 8.2 0.1 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-Di19 PF05605.7 ESA12834.1 - 0.19 11.8 7.2 0.37 10.9 1.5 2.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-TFIIB PF13453.1 ESA12834.1 - 0.25 10.5 2.2 5.4 6.2 0.2 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger PyrI_C PF02748.10 ESA12834.1 - 0.29 10.6 3.4 0.1 12.0 0.5 1.6 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-ribbon_3 PF13248.1 ESA12834.1 - 0.34 10.1 5.7 1.7 7.9 0.4 2.7 3 0 0 3 3 3 0 zinc-ribbon domain FANCL_C PF11793.3 ESA12834.1 - 0.43 10.5 3.8 1.2 9.1 2.6 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain C1_3 PF07649.7 ESA12834.1 - 0.81 9.7 5.2 7.9 6.6 0.1 2.8 3 0 0 3 3 3 0 C1-like domain IBR PF01485.16 ESA12834.1 - 0.82 9.5 6.9 0.26 11.1 1.4 2.0 1 1 0 2 2 2 0 IBR domain TF_Zn_Ribbon PF08271.7 ESA12834.1 - 1.6 8.1 5.3 3.6 6.9 0.1 2.5 3 0 0 3 3 2 0 TFIIB zinc-binding DUF2256 PF10013.4 ESA12834.1 - 1.7 8.4 11.2 0.5 10.1 1.2 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) TFIIS_C PF01096.13 ESA12834.1 - 1.7 8.3 7.4 0.5 10.0 1.3 2.4 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) Ogr_Delta PF04606.7 ESA12834.1 - 2.1 8.0 9.1 0.38 10.4 2.9 2.3 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger Zn_ribbon_recom PF13408.1 ESA12834.1 - 2.6 8.3 7.1 38 4.6 5.0 2.4 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-BED PF02892.10 ESA12834.1 - 2.9 7.7 11.9 0.51 10.1 1.0 2.9 1 1 2 3 3 3 0 BED zinc finger zf-HYPF PF07503.7 ESA12834.1 - 3.6 7.0 6.0 20 4.7 0.1 3.1 3 0 0 3 3 3 0 HypF finger Rad50_zn_hook PF04423.9 ESA12834.1 - 4.2 6.9 5.5 14 5.2 0.4 2.6 2 1 1 3 3 3 0 Rad50 zinc hook motif zf-RING_5 PF14634.1 ESA12834.1 - 4.6 7.0 10.1 0.95 9.2 0.2 2.7 2 1 0 2 2 2 0 zinc-RING finger domain zf-RING_3 PF14369.1 ESA12834.1 - 5.3 7.1 9.0 6.6 6.8 1.1 3.0 3 0 0 3 3 3 0 zinc-finger zinc_ribbon_2 PF13240.1 ESA12834.1 - 5.5 6.6 8.7 6.7 6.3 0.9 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 ESA12834.1 - 5.5 6.8 12.3 3.6 7.4 3.9 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-HIT PF04438.11 ESA12834.1 - 7.3 6.3 8.1 7.7 6.2 0.2 2.8 3 0 0 3 3 3 0 HIT zinc finger FYVE PF01363.16 ESA12834.1 - 9.9 6.1 10.9 1.7 8.6 0.1 2.9 2 1 0 2 2 2 0 FYVE zinc finger F-box-like PF12937.2 ESA12835.1 - 7.9e-08 31.9 0.8 2.6e-07 30.2 0.5 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA12835.1 - 1.1 9.0 5.7 21 4.9 4.0 3.0 1 1 0 1 1 1 0 F-box domain PyrI_C PF02748.10 ESA12837.1 - 0.084 12.3 2.6 0.092 12.1 0.1 2.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Sigma70_r4 PF04545.11 ESA12839.1 - 0.11 11.8 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 p450 PF00067.17 ESA12841.1 - 3.7e-55 187.2 0.0 4.3e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA12842.1 - 3e-21 75.4 0.2 3.6e-21 75.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3149 PF11346.3 ESA12842.1 - 0.26 10.8 3.2 0.72 9.4 2.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) UvsW PF11637.3 ESA12842.1 - 3.9 7.2 5.8 0.97 9.1 0.2 2.5 3 0 0 3 3 3 0 ATP-dependant DNA helicase UvsW GCR PF02155.10 ESA12846.1 - 0.047 12.4 0.1 0.061 12.0 0.1 1.1 1 0 0 1 1 1 0 Glucocorticoid receptor Baculo_PEP_C PF04513.7 ESA12846.1 - 0.097 12.4 1.1 0.18 11.6 0.8 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus BBP1_C PF15272.1 ESA12848.1 - 2.7e-06 27.0 12.4 3.1e-06 26.8 8.6 1.1 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal HTH_39 PF14090.1 ESA12848.1 - 0.0025 17.2 1.1 0.13 11.7 0.0 2.7 1 1 1 2 2 2 1 Helix-turn-helix domain DUF972 PF06156.8 ESA12848.1 - 0.0088 16.3 17.2 0.32 11.3 3.8 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF972) BLOC1_2 PF10046.4 ESA12848.1 - 0.009 16.1 1.3 0.009 16.1 0.9 2.3 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Halo_GVPC PF05465.8 ESA12848.1 - 0.026 14.4 1.0 1.1 9.2 0.0 3.0 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat CALCOCO1 PF07888.6 ESA12848.1 - 0.052 11.8 11.4 0.061 11.6 7.9 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Golgin_A5 PF09787.4 ESA12848.1 - 0.059 11.8 10.4 0.072 11.6 7.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Fez1 PF06818.10 ESA12848.1 - 0.07 13.1 9.4 0.093 12.7 6.5 1.3 1 0 0 1 1 1 0 Fez1 CCDC155 PF14662.1 ESA12848.1 - 0.1 12.2 16.2 0.85 9.1 11.2 2.1 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 CcmH PF03918.9 ESA12848.1 - 0.13 11.2 0.4 0.26 10.2 0.2 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein IncA PF04156.9 ESA12848.1 - 0.16 11.5 13.6 0.29 10.7 7.3 1.9 1 1 1 2 2 2 0 IncA protein TMF_TATA_bd PF12325.3 ESA12848.1 - 0.17 11.6 16.5 0.074 12.7 1.9 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 ESA12848.1 - 0.18 11.6 18.0 5.5 6.9 0.5 4.5 1 1 2 4 4 4 0 Basic region leucine zipper DUF4201 PF13870.1 ESA12848.1 - 0.19 11.1 14.3 1 8.7 9.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Atg14 PF10186.4 ESA12848.1 - 0.22 10.4 12.7 0.31 9.9 8.8 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 bZIP_1 PF00170.16 ESA12848.1 - 0.26 11.2 15.8 0.2 11.6 3.1 3.6 1 1 2 3 3 3 0 bZIP transcription factor DUF4398 PF14346.1 ESA12848.1 - 0.46 10.5 6.6 1.6 8.8 0.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) TMPIT PF07851.8 ESA12848.1 - 0.48 9.4 7.8 0.57 9.2 5.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein Pox_A_type_inc PF04508.7 ESA12848.1 - 0.57 10.0 0.2 0.57 10.0 0.1 4.1 4 1 0 4 4 3 0 Viral A-type inclusion protein repeat NYD-SP28 PF14772.1 ESA12848.1 - 0.61 10.1 13.4 0.54 10.3 1.7 2.3 1 1 1 2 2 2 0 Sperm tail DUF904 PF06005.7 ESA12848.1 - 0.82 9.9 21.3 1.9e+03 -0.8 14.7 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF904) NYD-SP28_assoc PF14775.1 ESA12848.1 - 1 9.1 7.7 15 5.4 0.2 3.8 2 2 2 4 4 4 0 Sperm tail C-terminal domain DUF2407_C PF13373.1 ESA12848.1 - 1.1 9.2 9.9 12 5.7 6.9 2.1 1 1 0 1 1 1 0 DUF2407 C-terminal domain DUF2216 PF10226.4 ESA12848.1 - 1.1 8.7 10.7 3 7.3 2.7 2.3 1 1 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) DUF724 PF05266.9 ESA12848.1 - 1.5 8.3 13.8 14 5.2 9.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Nup54 PF13874.1 ESA12848.1 - 1.9 8.1 11.5 6.2 6.4 3.4 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TSC22 PF01166.13 ESA12848.1 - 2.2 8.2 15.3 5.9 6.9 0.7 3.3 1 1 2 3 3 3 0 TSC-22/dip/bun family Viral_P18 PF04521.8 ESA12848.1 - 2.6 7.5 8.7 1.4 8.3 2.0 2.4 1 1 2 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein DUF2935 PF11155.3 ESA12848.1 - 3.1 7.8 6.9 6.4 6.8 4.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) Occludin_ELL PF07303.8 ESA12848.1 - 3.2 8.5 7.1 1.3 9.7 0.9 2.1 1 1 0 2 2 2 0 Occludin homology domain DUF641 PF04859.7 ESA12848.1 - 3.8 7.2 10.8 0.3 10.8 1.8 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ADIP PF11559.3 ESA12848.1 - 3.9 7.3 18.4 1.4 8.8 4.9 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF603 PF04645.7 ESA12848.1 - 3.9 7.3 13.5 0.23 11.3 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function, DUF603 CENP-H PF05837.7 ESA12848.1 - 6.3 7.0 15.5 1.4 9.1 5.6 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FlaC_arch PF05377.6 ESA12848.1 - 6.9 6.6 8.8 10 6.1 0.7 2.8 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) UPF0242 PF06785.6 ESA12848.1 - 7.9 5.0 9.4 9.6 4.7 6.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF2203 PF09969.4 ESA12848.1 - 8.1 6.6 7.5 46 4.2 5.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DivIC PF04977.10 ESA12848.1 - 9 5.8 17.8 4 6.9 2.8 3.6 1 1 2 3 3 3 0 Septum formation initiator ACCA PF03255.9 ESA12848.1 - 9.7 5.7 10.0 2.9 7.4 1.1 2.3 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Sel1 PF08238.7 ESA12851.1 - 1.5e-25 89.0 4.2 3.6e-12 46.4 0.2 3.0 3 0 0 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA12851.1 - 1.6 8.6 4.8 1.9 8.4 0.3 2.3 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain La PF05383.12 ESA12854.1 - 1.1e-19 70.0 0.2 2.6e-19 68.7 0.1 1.7 1 0 0 1 1 1 1 La domain GCIP PF13324.1 ESA12855.1 - 0.064 12.4 0.3 0.071 12.3 0.2 1.0 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Dimer_Tnp_hAT PF05699.9 ESA12856.1 - 4.4e-12 45.4 0.1 1.2e-11 44.0 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Nbs1_C PF08599.5 ESA12856.1 - 0.027 14.3 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Carbpep_Y_N PF05388.6 ESA12856.1 - 0.08 13.1 1.3 0.97 9.6 0.1 2.5 2 1 1 3 3 3 0 Carboxypeptidase Y pro-peptide TMEM154 PF15102.1 ESA12859.1 - 0.092 12.4 2.0 0.42 10.2 0.3 2.3 2 0 0 2 2 2 0 TMEM154 protein family DUF2370 PF10176.4 ESA12859.1 - 0.23 10.7 0.8 16 4.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) OAD_gamma PF04277.8 ESA12859.1 - 0.23 11.8 3.4 0.57 10.5 0.3 2.9 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF456 PF04306.8 ESA12859.1 - 0.31 11.0 4.8 1.3 8.9 1.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF456) p450 PF00067.17 ESA12864.1 - 3.1e-49 167.7 0.0 3.5e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA12865.1 - 2.3e-15 56.1 0.1 2.9e-15 55.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA12866.1 - 6.5e-50 169.9 1.6 7.7e-49 166.4 1.1 1.9 1 1 0 1 1 1 1 Cytochrome P450 Piwi PF02171.12 ESA12867.1 - 4.3e-07 29.2 0.2 8.5e-07 28.2 0.1 1.5 1 1 0 1 1 1 1 Piwi domain Sel1 PF08238.7 ESA12869.1 - 5.1e-73 239.9 16.3 3.2e-10 40.2 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat MIT PF04212.13 ESA12869.1 - 0.011 15.5 28.3 0.68 9.8 0.3 5.7 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain Acetyltransf_1 PF00583.19 ESA12869.1 - 0.021 14.8 1.1 32 4.6 0.0 3.8 2 2 2 4 4 4 0 Acetyltransferase (GNAT) family NSF PF02071.15 ESA12869.1 - 0.66 10.7 14.0 91 4.3 0.1 6.9 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat Pkinase_Tyr PF07714.12 ESA12870.1 - 1.7e-36 125.6 0.0 2.7e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA12870.1 - 5.6e-34 115.8 6.1 2.6e-08 34.2 0.0 5.6 5 1 0 5 5 5 5 Sel1 repeat Pkinase PF00069.20 ESA12870.1 - 2.9e-29 102.0 0.0 4.4e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA12870.1 - 0.0054 15.8 0.0 0.016 14.3 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA12870.1 - 0.027 14.2 0.1 0.042 13.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family AdoMet_MTase PF07757.8 ESA12870.1 - 0.027 14.5 0.2 6.6 6.8 0.0 2.8 2 1 1 3 3 3 0 Predicted AdoMet-dependent methyltransferase MIT PF04212.13 ESA12870.1 - 0.13 12.1 2.3 22 4.9 0.7 3.2 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain NYN PF01936.13 ESA12871.1 - 3.9e-05 23.9 0.0 4.5e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 NYN domain Pox_D2 PF04701.8 ESA12871.1 - 0.068 13.1 0.1 0.083 12.8 0.1 1.2 1 0 0 1 1 1 0 Pox virus D2 protein DUF267 PF03268.9 ESA12872.1 - 0.0079 15.0 0.1 0.0085 14.9 0.1 1.1 1 0 0 1 1 1 1 Caenorhabditis protein of unknown function, DUF267 DUF1192 PF06698.6 ESA12872.1 - 0.018 14.8 0.3 0.027 14.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Sel1 PF08238.7 ESA12873.1 - 2.2e-91 298.2 22.5 3.5e-12 46.5 0.4 10.1 10 0 0 10 10 10 10 Sel1 repeat AdoMet_MTase PF07757.8 ESA12873.1 - 9.6e-07 28.9 8.9 1.5 9.0 0.1 7.5 1 1 5 8 8 8 1 Predicted AdoMet-dependent methyltransferase TFIIB PF00382.14 ESA12873.1 - 0.0029 17.3 1.2 28 4.6 0.0 5.9 8 0 0 8 8 8 1 Transcription factor TFIIB repeat MIT PF04212.13 ESA12873.1 - 0.0033 17.2 30.1 0.67 9.8 1.6 7.5 3 3 4 7 7 7 6 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA12873.1 - 0.0041 17.4 14.7 18 6.0 0.3 7.8 9 0 0 9 9 9 2 Tetratricopeptide repeat PC_rep PF01851.17 ESA12875.1 - 6.6e-05 22.9 0.1 0.0073 16.4 0.0 2.5 2 0 0 2 2 2 2 Proteasome/cyclosome repeat Synapsin_C PF02750.9 ESA12875.1 - 0.026 13.6 0.0 0.11 11.6 0.0 1.7 1 1 1 2 2 2 0 Synapsin, ATP binding domain Diphthamide_syn PF01866.12 ESA12876.1 - 3.9e-119 397.4 0.0 6.8e-119 396.6 0.0 1.4 2 0 0 2 2 2 1 Putative diphthamide synthesis protein Bac_surface_Ag PF01103.18 ESA12877.1 - 7e-50 170.3 0.7 8.7e-50 170.0 0.5 1.1 1 0 0 1 1 1 1 Surface antigen DUF2373 PF10180.4 ESA12878.1 - 0.014 14.9 2.8 1.9 8.1 0.1 3.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) Fer4_9 PF13187.1 ESA12878.1 - 0.015 15.5 2.4 4.1 7.7 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 ESA12878.1 - 0.021 15.1 0.0 0.34 11.3 0.0 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain UPF0029 PF01205.14 ESA12878.1 - 0.09 12.4 0.4 2 8.1 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein family UPF0029 Glutaredoxin PF00462.19 ESA12878.1 - 0.81 9.7 3.6 18 5.4 0.2 3.0 2 2 0 2 2 2 0 Glutaredoxin Fer4_16 PF13484.1 ESA12878.1 - 5.7 7.7 11.9 13 6.6 1.6 2.9 2 2 1 3 3 3 0 4Fe-4S double cluster binding domain AAA PF00004.24 ESA12880.1 - 0.0026 17.9 0.0 0.0062 16.7 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA12880.1 - 0.011 15.8 0.0 0.17 12.0 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESA12880.1 - 0.012 16.4 0.1 0.37 11.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.12 ESA12882.1 - 1.2e-37 129.3 0.4 1.1e-31 109.9 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA12882.1 - 4.1e-37 127.7 2.1 6.2e-33 114.0 0.6 2.0 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA12882.1 - 9.2e-05 22.2 0.0 0.13 11.9 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA12882.1 - 0.00055 19.3 0.3 0.0013 18.0 0.2 1.7 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA12882.1 - 0.0011 18.4 0.2 0.0014 17.9 0.1 1.3 1 1 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA12882.1 - 0.0018 17.5 0.4 0.0029 16.8 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA12882.1 - 0.0074 15.3 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA12882.1 - 0.24 10.9 2.7 0.45 10.0 1.9 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 ESA12883.1 - 1.7e-30 105.9 0.5 1.6e-29 102.8 0.4 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12883.1 - 1.3e-25 90.0 0.3 1.3e-25 90.0 0.2 1.5 2 0 0 2 2 2 1 Protein kinase domain CCDC14 PF15254.1 ESA12883.1 - 1.1 7.5 6.1 1.7 6.9 4.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 Amidase_2 PF01510.20 ESA12884.1 - 0.0034 17.4 0.0 0.0042 17.1 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase MobC PF05713.6 ESA12885.1 - 0.15 12.0 0.2 0.31 11.0 0.1 1.5 1 1 1 2 2 2 0 Bacterial mobilisation protein (MobC) Pkinase PF00069.20 ESA12886.1 - 3.3e-24 85.4 0.0 3.6e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12886.1 - 1.3e-19 70.3 0.0 1.4e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA12886.1 - 0.00054 19.7 0.0 0.034 13.8 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA12886.1 - 0.0091 14.9 0.0 0.01 14.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA12886.1 - 0.01 14.9 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA12886.1 - 0.048 12.9 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family SpoOE-like PF09388.5 ESA12889.1 - 0.022 14.2 0.1 0.035 13.6 0.1 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein Hemagglutinin PF00509.13 ESA12889.1 - 0.03 12.4 0.2 0.03 12.4 0.1 1.0 1 0 0 1 1 1 0 Haemagglutinin DegS PF05384.6 ESA12889.1 - 0.032 13.4 0.2 0.18 11.0 0.1 1.9 1 1 0 1 1 1 0 Sensor protein DegS FlaC_arch PF05377.6 ESA12889.1 - 0.036 13.9 0.1 0.07 13.0 0.1 1.5 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) She2p PF11435.3 ESA12891.1 - 0.028 13.7 0.1 0.038 13.3 0.1 1.2 1 0 0 1 1 1 0 RNA binding protein She2p Imm26 PF15572.1 ESA12892.1 - 0.089 12.9 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 26 DUF4172 PF13776.1 ESA12892.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4172) p450 PF00067.17 ESA12894.1 - 9.8e-63 212.2 0.0 1.1e-62 212.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SRP72 PF08492.7 ESA12894.1 - 0.0072 16.6 0.1 0.016 15.5 0.1 1.6 1 0 0 1 1 1 1 SRP72 RNA-binding domain Pkinase_Tyr PF07714.12 ESA12895.1 - 1.9e-19 69.7 1.5 3e-16 59.2 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA12895.1 - 2.7e-16 59.4 1.7 1.1e-13 51.0 0.1 2.6 2 1 1 3 3 3 2 Protein kinase domain APH PF01636.18 ESA12895.1 - 0.012 15.3 0.0 0.024 14.3 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA12895.1 - 0.064 12.3 0.0 0.13 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA12895.1 - 0.1 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Med26 PF08711.6 ESA12896.1 - 3.7e-14 51.9 0.0 7.6e-14 50.9 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain REGB_T4 PF10715.4 ESA12897.1 - 0.047 13.7 0.1 0.059 13.4 0.1 1.1 1 0 0 1 1 1 0 Endoribonuclease RegB T4-bacteriophage encoded OTT_1508_deam PF14441.1 ESA12897.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 OTT_1508-like deaminase AAA_22 PF13401.1 ESA12898.1 - 0.0001 22.4 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA12898.1 - 0.0013 18.6 0.0 0.011 15.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain SieB PF14163.1 ESA12898.1 - 0.0017 17.9 0.1 0.0045 16.5 0.1 1.6 1 0 0 1 1 1 1 Superinfection exclusion protein B Arch_ATPase PF01637.13 ESA12898.1 - 0.0077 15.9 0.0 0.15 11.7 0.0 2.7 2 2 0 2 2 2 1 Archaeal ATPase AAA PF00004.24 ESA12898.1 - 0.046 13.9 0.0 0.12 12.5 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SpoIIIAH PF12685.2 ESA12899.1 - 6.7 6.1 10.7 64 2.9 7.4 2.2 1 1 0 1 1 1 0 SpoIIIAH-like protein Na_H_Exchanger PF00999.16 ESA12900.1 - 4.7e-53 180.0 49.3 6.7e-53 179.5 34.2 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Coprogen_oxidas PF01218.13 ESA12901.1 - 8.6e-135 448.0 0.2 1e-134 447.7 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF974 PF06159.8 ESA12902.1 - 5.1e-61 206.2 10.2 1.4e-59 201.5 7.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.2 ESA12902.1 - 3.8e-08 33.0 15.4 5.2e-07 29.2 0.0 3.2 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 Sec62 PF03839.11 ESA12902.1 - 8.6 5.6 12.8 0.89 8.9 5.7 1.5 2 0 0 2 2 2 0 Translocation protein Sec62 FF PF01846.14 ESA12903.1 - 7.8e-52 173.0 47.2 9.4e-15 54.3 1.5 6.5 6 0 0 6 6 6 6 FF domain WW PF00397.21 ESA12903.1 - 9.2e-14 50.9 10.4 3.6e-10 39.5 0.6 4.0 4 0 0 4 4 4 2 WW domain Herpes_capsid PF06112.6 ESA12904.1 - 2 8.4 7.3 2.5 8.1 5.1 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein HMG_box PF00505.14 ESA12907.1 - 0.028 14.6 2.3 1.5 9.1 0.0 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box DUF1433 PF07252.6 ESA12909.1 - 0.053 13.7 0.3 0.092 12.9 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1433) DUF2602 PF10782.4 ESA12910.1 - 0.046 13.5 0.1 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2602) Guanylate_cyc PF00211.15 ESA12910.1 - 0.064 12.6 0.1 0.09 12.1 0.1 1.2 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.12 ESA12911.1 - 1.4e-43 148.8 0.0 2.1e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12911.1 - 8.4e-42 143.1 0.3 2.4e-41 141.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain YchF-GTPase_C PF06071.8 ESA12911.1 - 0.0043 16.7 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) RBD-FIP PF09457.5 ESA12913.1 - 0.2 11.4 0.9 0.51 10.1 0.6 1.7 1 0 0 1 1 1 0 FIP domain Striatin PF08232.7 ESA12913.1 - 0.99 9.7 9.0 1.8 8.8 6.2 1.6 1 1 0 1 1 1 0 Striatin family DUF972 PF06156.8 ESA12913.1 - 2.2 8.6 8.7 8.8 6.7 5.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Epimerase PF01370.16 ESA12915.1 - 5.7e-30 104.4 0.0 9.2e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glycos_transf_2 PF00535.21 ESA12915.1 - 1e-12 48.0 0.1 8.2e-12 45.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 3Beta_HSD PF01073.14 ESA12915.1 - 9.7e-07 27.7 0.0 1.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_tranf_2_2 PF10111.4 ESA12915.1 - 3.1e-06 26.5 0.1 9.2e-06 24.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Polysacc_synt_2 PF02719.10 ESA12915.1 - 3.7e-05 22.7 0.0 0.0051 15.7 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Glyco_tranf_2_3 PF13641.1 ESA12915.1 - 0.00036 20.4 0.0 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF2207 PF09972.4 ESA12916.1 - 0.015 13.8 3.4 0.025 13.1 2.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_Treg PF04761.7 ESA12918.1 - 0.038 13.7 0.8 0.091 12.5 0.5 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator Vps5 PF09325.5 ESA12918.1 - 0.066 12.4 2.8 0.47 9.6 0.4 2.1 2 0 0 2 2 2 0 Vps5 C terminal like ECM11 PF15463.1 ESA12918.1 - 0.077 13.2 0.0 0.077 13.2 0.0 2.5 2 0 0 2 2 2 0 Extracellular mutant protein 11 ASD2 PF08687.6 ESA12918.1 - 0.32 10.3 5.0 0.15 11.3 0.6 1.9 1 1 0 2 2 2 0 Apx/Shroom domain ASD2 DUF3642 PF12182.3 ESA12918.1 - 0.55 10.6 3.7 0.35 11.3 1.2 1.6 2 0 0 2 2 2 0 Bacterial lipoprotein SET PF00856.23 ESA12919.1 - 3.3e-07 30.7 0.0 5.7e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 SET domain ATP13 PF12921.2 ESA12919.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase expression TPR_8 PF13181.1 ESA12919.1 - 0.083 12.7 0.1 1.2 9.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.15 ESA12919.1 - 0.11 12.5 0.1 4.2 7.5 0.0 2.9 2 0 0 2 2 2 0 PPR repeat DUF2789 PF10982.3 ESA12920.1 - 0.064 13.2 0.8 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) GPS PF01825.16 ESA12920.1 - 1.3 9.1 11.6 0.99 9.5 0.1 2.9 3 0 0 3 3 3 0 Latrophilin/CL-1-like GPS domain DnaB_2 PF07261.6 ESA12921.1 - 0.031 13.8 0.5 0.1 12.2 0.3 1.8 1 1 1 2 2 2 0 Replication initiation and membrane attachment DUF1371 PF07115.6 ESA12921.1 - 0.11 12.6 0.8 0.14 12.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1371) Nodulin PF02451.10 ESA12922.1 - 0.014 14.8 0.2 0.016 14.6 0.2 1.1 1 0 0 1 1 1 0 Nodulin Troponin PF00992.15 ESA12923.1 - 0.012 15.6 2.1 0.014 15.4 1.4 1.1 1 0 0 1 1 1 0 Troponin Snf7 PF03357.16 ESA12923.1 - 0.066 12.5 1.9 0.072 12.4 1.3 1.0 1 0 0 1 1 1 0 Snf7 ANAPC15 PF15243.1 ESA12924.1 - 0.63 10.1 3.3 14 5.8 2.3 2.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 15 Peptidase_U49 PF10463.4 ESA12927.1 - 0.027 14.2 0.3 0.049 13.4 0.2 1.4 1 0 0 1 1 1 0 Peptidase U49 HEXIM PF15313.1 ESA12927.1 - 0.04 14.0 2.5 0.22 11.6 1.8 2.3 1 1 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein DUF1461 PF07314.6 ESA12928.1 - 0.031 14.0 0.3 0.034 13.8 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) DHHA2 PF02833.9 ESA12929.1 - 1e-10 41.8 0.2 2.2e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 ESA12929.1 - 3.9e-08 33.0 0.0 7.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 DHH family UCH PF00443.24 ESA12930.1 - 9.3e-48 162.6 6.2 1.8e-47 161.7 4.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 ESA12930.1 - 1.4e-14 53.2 0.0 1.6e-08 33.8 0.0 2.7 2 0 0 2 2 2 2 A repeated domain in UCH-protein UCH_1 PF13423.1 ESA12930.1 - 2.8e-12 46.7 9.7 8.2e-06 25.4 0.0 3.1 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Pox_A_type_inc PF04508.7 ESA12930.1 - 3.2 7.7 6.1 22 5.1 0.1 3.7 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Pkinase_Tyr PF07714.12 ESA12933.1 - 5.9e-36 123.8 0.0 7.4e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA12933.1 - 9.2e-34 116.7 0.0 1.4e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Spt5-NGN PF03439.8 ESA12934.1 - 9.2e-06 25.3 8.8 1.4 8.7 0.0 6.6 7 0 0 7 7 7 2 Early transcription elongation factor of RNA pol II, NGN section DUF4618 PF15397.1 ESA12934.1 - 8.7e-05 21.9 2.8 2.9 7.1 0.0 4.4 4 0 0 4 4 4 2 Domain of unknown function (DUF4618) PA14_2 PF10528.4 ESA12934.1 - 0.00012 22.0 13.2 1 9.3 0.1 5.6 5 0 0 5 5 5 2 GLEYA domain DUF1694 PF07997.6 ESA12934.1 - 0.024 14.5 5.0 17 5.3 0.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1694) FerB PF08150.7 ESA12934.1 - 0.046 13.7 1.2 2.1e+02 2.0 0.0 4.8 5 0 0 5 5 5 0 FerB (NUC096) domain ETRAMP PF09716.5 ESA12934.1 - 0.051 13.5 10.1 13 5.7 0.2 5.0 5 0 0 5 5 5 0 Malarial early transcribed membrane protein (ETRAMP) DUF3588 PF12140.3 ESA12934.1 - 0.12 12.5 2.9 45 4.1 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3588) Imm20 PF15568.1 ESA12934.1 - 0.89 9.4 20.5 0.26 11.1 0.3 5.8 6 0 0 6 6 6 0 Immunity protein 20 TPR_8 PF13181.1 ESA12934.1 - 7 6.6 12.1 94 3.1 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DnaJ_CXXCXGXG PF00684.14 ESA12934.1 - 7.4 6.7 13.6 5.6 7.0 0.2 4.0 5 0 0 5 5 5 0 DnaJ central domain IL15 PF02372.10 ESA12934.1 - 9.2 6.0 24.8 1.2 8.9 0.1 5.8 5 1 0 5 5 5 0 Interleukin 15 p450 PF00067.17 ESA12935.1 - 1.9e-39 135.4 0.0 2.1e-39 135.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB PF00651.26 ESA12937.1 - 2e-08 34.1 0.0 3.8e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF4618 PF15397.1 ESA12940.1 - 0.063 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DDE_1 PF03184.14 ESA12941.1 - 1.2e-22 80.1 0.9 1.3e-22 80.0 0.6 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease BTB PF00651.26 ESA12943.1 - 2.9e-12 46.5 3.0 5.4e-11 42.4 0.3 2.9 2 2 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA12943.1 - 0.035 13.9 0.6 0.75 9.6 0.0 2.8 2 1 1 3 3 3 0 BTB And C-terminal Kelch Bacillus_HBL PF05791.6 ESA12945.1 - 0.054 12.8 1.7 0.072 12.4 0.2 1.7 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) AAA_5 PF07728.9 ESA12946.1 - 0.00021 21.0 0.0 0.00066 19.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA12946.1 - 0.018 15.2 0.0 0.05 13.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA12947.1 - 3.1e-05 23.7 0.0 0.00013 21.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA12947.1 - 0.0012 19.0 0.0 0.0033 17.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM PF00493.18 ESA12947.1 - 0.036 12.8 0.3 0.11 11.3 0.0 1.8 2 0 0 2 2 2 0 MCM2/3/5 family CPSF73-100_C PF11718.3 ESA12948.1 - 0.016 14.5 0.5 0.018 14.3 0.4 1.0 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Methyltransf_23 PF13489.1 ESA12949.1 - 1.6e-15 57.2 0.0 2.2e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA12949.1 - 1.6e-14 54.1 0.0 2.7e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA12949.1 - 1.9e-13 50.5 0.0 3.7e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA12949.1 - 3.8e-12 46.5 0.0 7.3e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA12949.1 - 5.7e-11 42.2 0.0 1.7e-10 40.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA12949.1 - 8.6e-09 34.8 0.0 1.2e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA12949.1 - 5e-08 33.5 0.0 1.5e-07 31.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA12949.1 - 3.6e-06 26.1 0.0 8.7e-06 24.9 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.14 ESA12949.1 - 7.4e-06 26.0 0.0 1.8e-05 24.7 0.0 1.6 1 1 1 2 2 2 1 FtsJ-like methyltransferase MetW PF07021.7 ESA12949.1 - 5.4e-05 22.6 0.0 8.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.15 ESA12949.1 - 0.0024 16.9 0.0 0.0045 16.0 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 ESA12949.1 - 0.013 15.5 0.0 0.048 13.6 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.10 ESA12949.1 - 0.029 14.0 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_29 PF03141.11 ESA12949.1 - 0.031 12.6 0.0 0.068 11.4 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Claudin_3 PF06653.6 ESA12950.1 - 0.064 12.9 0.7 0.09 12.4 0.5 1.2 1 0 0 1 1 1 0 Tight junction protein, Claudin-like DEK_C PF08766.6 ESA12951.1 - 3.9 7.3 6.0 10 5.9 0.3 2.9 3 0 0 3 3 3 0 DEK C terminal domain W2 PF02020.13 ESA12952.1 - 1.8e-20 72.6 1.7 8.8e-20 70.4 0.5 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon WD40 PF00400.27 ESA12953.1 - 5.4e-52 171.9 17.4 1.8e-09 37.1 0.2 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat Mso1_Sec1_bdg PF14475.1 ESA12954.1 - 6.8e-08 31.7 0.1 1.3e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 AAA-ATPase_like PF09820.4 ESA12955.1 - 3.8e-14 52.5 1.4 5.9e-14 51.8 1.0 1.2 1 0 0 1 1 1 1 Predicted AAA-ATPase Calici_coat_C PF08435.6 ESA12957.1 - 0.099 11.9 0.1 0.29 10.3 0.0 1.7 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal Retrotrans_gag PF03732.12 ESA12958.1 - 2.3e-09 37.1 0.1 8.5e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 Retrotransposon gag protein zf-CCHC PF00098.18 ESA12958.1 - 5.7e-07 29.1 1.2 9e-07 28.5 0.8 1.3 1 0 0 1 1 1 1 Zinc knuckle Syntaxin-6_N PF09177.6 ESA12958.1 - 0.0066 16.8 0.2 0.022 15.1 0.0 1.9 2 0 0 2 2 2 1 Syntaxin 6, N-terminal Shugoshin_N PF07558.6 ESA12958.1 - 0.15 11.8 0.1 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region RNase_H2_suC PF08615.6 ESA12959.1 - 0.027 14.3 0.2 0.054 13.3 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Spuma_A9PTase PF03539.9 ESA12959.1 - 0.037 13.9 0.2 0.072 12.9 0.1 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) Virulence_fact PF13769.1 ESA12959.1 - 0.26 11.1 5.2 0.94 9.3 3.6 2.0 1 0 0 1 1 1 0 Virulence factor PBP1_TM PF14812.1 ESA12959.1 - 0.36 11.1 5.1 0.93 9.8 3.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Adeno_terminal PF02459.10 ESA12959.1 - 0.53 8.3 7.1 0.76 7.8 5.0 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein 7tm_6 PF02949.15 ESA12960.1 - 0.028 13.2 0.8 0.026 13.3 0.5 1.0 1 0 0 1 1 1 0 7tm Odorant receptor DUF4229 PF14012.1 ESA12960.1 - 0.37 10.7 1.6 0.59 10.0 1.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4229) BIR PF00653.16 ESA12963.1 - 0.088 13.2 0.3 0.11 12.9 0.2 1.3 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain DUF2393 PF09624.5 ESA12964.1 - 0.27 10.7 3.3 4.2 6.8 0.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2393) zf-C2H2_4 PF13894.1 ESA12965.1 - 0.059 13.7 5.8 0.88 10.0 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger DUF1451 PF07295.6 ESA12965.1 - 0.065 13.0 0.6 0.11 12.2 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) zf-C4_ClpX PF06689.8 ESA12965.1 - 0.11 11.9 4.8 0.27 10.8 0.1 2.7 3 0 0 3 3 3 0 ClpX C4-type zinc finger Ribosomal_S14 PF00253.16 ESA12965.1 - 0.21 10.9 3.6 0.11 11.9 0.5 2.0 2 1 0 2 2 2 0 Ribosomal protein S14p/S29e DZR PF12773.2 ESA12965.1 - 0.91 9.3 4.7 3 7.7 3.3 2.0 1 1 0 1 1 1 0 Double zinc ribbon rve PF00665.21 ESA12966.1 - 5e-12 45.9 0.0 8.4e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Kelch_5 PF13854.1 ESA12967.1 - 2.4e-07 30.5 1.0 0.17 11.9 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA12967.1 - 3.6e-07 30.0 0.9 0.016 15.3 0.0 3.4 3 0 0 3 3 3 2 Kelch motif LVIVD PF08309.6 ESA12967.1 - 9.7e-05 21.2 1.0 0.00021 20.2 0.7 1.6 1 0 0 1 1 1 1 LVIVD repeat Kelch_3 PF13415.1 ESA12967.1 - 0.00017 21.6 0.5 0.072 13.2 0.0 3.5 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA12967.1 - 0.00018 21.1 0.9 0.032 14.0 0.0 3.0 4 0 0 4 4 3 1 Galactose oxidase, central domain DUF443 PF04276.7 ESA12967.1 - 0.0011 18.4 2.0 0.0027 17.1 1.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF443) TMEM154 PF15102.1 ESA12967.1 - 0.0024 17.6 0.1 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family Vpu PF00558.14 ESA12967.1 - 0.016 14.7 0.2 0.03 13.8 0.2 1.4 1 0 0 1 1 1 0 Vpu protein Kelch_1 PF01344.20 ESA12967.1 - 0.017 14.6 0.9 1.9 8.0 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Rax2 PF12768.2 ESA12967.1 - 0.018 14.3 0.0 2.1 7.4 0.0 2.2 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Rifin_STEVOR PF02009.11 ESA12967.1 - 0.025 14.2 1.7 0.041 13.5 1.2 1.3 1 0 0 1 1 1 0 Rifin/stevor family Chordopox_A13L PF05961.6 ESA12967.1 - 0.025 14.4 4.4 0.025 14.4 3.1 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF3609 PF12259.3 ESA12967.1 - 0.055 12.1 0.1 0.081 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3609) Kelch_2 PF07646.10 ESA12967.1 - 0.08 12.7 0.5 52 3.8 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Pox_A14 PF05767.7 ESA12967.1 - 0.082 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 YajC PF02699.10 ESA12967.1 - 0.098 12.3 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit DUF4051 PF13260.1 ESA12967.1 - 0.4 10.0 2.1 0.9 8.9 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) Bunya_G1 PF03557.10 ESA12969.1 - 0.0032 15.3 2.2 0.0035 15.2 1.5 1.0 1 0 0 1 1 1 1 Bunyavirus glycoprotein G1 IBR PF01485.16 ESA12970.1 - 7.7e-14 51.3 34.5 3.2e-11 42.9 4.2 4.1 3 1 1 4 4 4 3 IBR domain zf-ribbon_3 PF13248.1 ESA12970.1 - 0.28 10.4 6.3 5.5 6.3 0.3 3.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-ISL3 PF14690.1 ESA12970.1 - 2.1 8.4 12.6 2.5 8.1 0.7 3.0 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 IBR PF01485.16 ESA12971.1 - 1.8e-18 66.1 20.5 3.6e-12 45.9 2.4 4.4 3 1 1 4 4 4 3 IBR domain Peptidase_M16 PF00675.15 ESA12972.1 - 1.4e-40 138.4 0.0 2.8e-40 137.4 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESA12972.1 - 5.4e-20 71.8 0.1 6.1e-17 61.8 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain MAR_sialic_bdg PF10564.4 ESA12972.1 - 0.016 14.9 0.1 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat F_actin_cap_B PF01115.12 ESA12974.1 - 8.4e-101 336.2 0.0 9.9e-101 335.9 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.12 ESA12974.1 - 0.019 14.0 0.1 0.043 12.8 0.1 1.8 1 1 1 2 2 2 0 F-actin capping protein alpha subunit SPRY PF00622.23 ESA12975.1 - 1e-10 41.7 0.4 1.8e-10 40.9 0.3 1.3 1 0 0 1 1 1 1 SPRY domain CAGE1 PF15066.1 ESA12975.1 - 0.068 11.6 0.3 0.096 11.1 0.2 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family Dimer_Tnp_hAT PF05699.9 ESA12977.1 - 1.8e-08 33.8 0.1 4.1e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Vps54 PF07928.7 ESA12977.1 - 0.0035 17.4 0.0 0.006 16.7 0.0 1.4 1 0 0 1 1 1 1 Vps54-like protein Retrotrans_gag PF03732.12 ESA12977.1 - 0.99 9.5 3.8 16 5.6 0.1 2.7 2 1 0 2 2 2 0 Retrotransposon gag protein ABC2_membrane PF01061.19 ESA12978.1 - 9.9e-20 70.6 13.9 1.5e-19 70.0 9.6 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 ESA12978.1 - 1.1e-05 24.6 13.8 1.3e-05 24.4 9.6 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 ESA12978.1 - 0.0017 17.2 7.1 0.002 17.0 4.9 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 ESA12978.1 - 0.63 9.1 17.8 0.06 12.5 8.3 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein Med25_VWA PF11265.3 ESA12979.1 - 0.065 12.2 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A MULE PF10551.4 ESA12983.1 - 3.8e-07 30.1 0.0 1.5e-05 25.0 0.0 3.0 3 1 0 3 3 3 1 MULE transposase domain Transposase_mut PF00872.13 ESA12983.1 - 7.5e-06 24.7 0.2 1.2e-05 24.0 0.2 1.2 1 0 0 1 1 1 1 Transposase, Mutator family SWIM PF04434.12 ESA12983.1 - 0.012 15.1 0.1 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 SWIM zinc finger SPRY PF00622.23 ESA12985.1 - 2.5e-10 40.4 0.3 4.3e-10 39.7 0.2 1.3 1 0 0 1 1 1 1 SPRY domain CAGE1 PF15066.1 ESA12985.1 - 0.12 10.8 0.5 0.16 10.3 0.3 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family Glycos_transf_2 PF00535.21 ESA12986.1 - 1.6e-32 112.5 0.0 2.2e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESA12986.1 - 1.6e-11 44.4 0.0 2.3e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESA12986.1 - 6.9e-09 35.1 0.0 9.4e-09 34.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 ESA12986.1 - 0.00021 20.6 0.0 0.00038 19.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Novirhabdo_Nv PF05554.6 ESA12986.1 - 0.057 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein Pkinase PF00069.20 ESA12987.1 - 2.1e-71 240.1 0.1 2.5e-71 239.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12987.1 - 1.1e-47 162.3 0.0 1.3e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA12987.1 - 1.3e-07 30.9 0.0 2.2e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA12987.1 - 0.00021 20.4 0.1 0.00034 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA12987.1 - 0.0006 19.6 0.1 0.0025 17.6 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA12987.1 - 0.00076 18.3 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.17 ESA12987.1 - 0.0067 15.7 0.1 0.021 14.1 0.0 1.8 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA12987.1 - 0.0081 15.5 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 ESA12987.1 - 0.0084 15.6 0.1 0.05 13.1 0.0 1.9 1 1 1 2 2 2 1 Choline/ethanolamine kinase Pkinase PF00069.20 ESA12988.1 - 0.00022 20.4 0.0 0.016 14.3 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA12988.1 - 0.0014 17.7 0.0 0.031 13.3 0.0 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase PI3_PI4_kinase PF00454.22 ESA12988.1 - 0.03 13.7 0.3 0.072 12.5 0.0 1.7 2 0 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase Thymidylate_kin PF02223.12 ESA12990.1 - 9e-18 64.3 0.0 1.1e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Thymidylate kinase HMG_box PF00505.14 ESA12991.1 - 2.1e-23 82.3 1.4 2.9e-23 81.8 1.0 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA12991.1 - 1.2e-09 38.3 0.2 1.4e-09 38.1 0.1 1.1 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.7 ESA12991.1 - 0.021 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 CHDNT (NUC034) domain NHL PF01436.16 ESA12992.1 - 0.26 11.3 2.9 5.5 7.1 0.0 3.7 4 0 0 4 4 4 0 NHL repeat DUF1850 PF08905.6 ESA12994.1 - 0.0033 17.2 0.0 0.0058 16.4 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1850) Pox_P4B PF03292.9 ESA12994.1 - 0.07 11.0 0.0 0.087 10.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P4B major core protein zf-LYAR PF08790.6 ESA12994.1 - 0.14 11.8 1.0 0.29 10.8 0.7 1.5 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger Kelch_2 PF07646.10 ESA12994.1 - 0.59 9.9 2.6 0.94 9.3 0.4 2.2 2 0 0 2 2 2 0 Kelch motif Tachylectin PF14517.1 ESA12996.1 - 0.019 14.2 1.6 3.6 6.8 0.0 3.6 1 1 1 4 4 4 0 Tachylectin RIH_assoc PF08454.6 ESA12997.1 - 0.076 12.6 1.6 0.11 12.0 1.1 1.3 1 0 0 1 1 1 0 RyR and IP3R Homology associated Chordopox_RPO7 PF05864.7 ESA12998.1 - 0.028 14.5 0.3 0.03 14.4 0.2 1.2 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Pkinase_Tyr PF07714.12 ESA13000.1 - 0.00015 20.9 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13000.1 - 0.0053 15.9 0.0 0.015 14.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain AA_permease_2 PF13520.1 ESA13001.1 - 2.3e-18 65.9 22.7 2.8e-18 65.6 15.7 1.0 1 0 0 1 1 1 1 Amino acid permease Sel1 PF08238.7 ESA13002.1 - 1.6e-59 197.0 12.1 9.7e-08 32.4 0.0 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA13002.1 - 2 9.0 6.4 16 6.2 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat MACPF PF01823.14 ESA13003.1 - 2.4e-05 24.1 0.3 2.4e-05 24.1 0.2 2.8 2 2 0 2 2 2 1 MAC/Perforin domain Reo_sigmaC PF04582.7 ESA13004.1 - 0.11 11.6 58.6 0.025 13.7 3.7 5.2 1 1 4 6 6 6 0 Reovirus sigma C capsid protein WEMBL PF05701.6 ESA13004.1 - 0.75 8.1 110.8 0.87 7.9 31.3 2.7 1 1 0 2 2 2 0 Weak chloroplast movement under blue light IncA PF04156.9 ESA13004.1 - 4.9 6.6 119.9 4.8 6.7 10.2 6.0 1 1 4 5 5 5 0 IncA protein Methyltransf_23 PF13489.1 ESA13005.1 - 3.5e-14 52.8 0.0 4.2e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA13005.1 - 2.6e-13 50.2 0.0 4e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13005.1 - 3e-12 46.3 0.0 3.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 ESA13005.1 - 7.4e-09 35.8 0.0 1.7e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13005.1 - 1.2e-08 35.4 0.0 7.2e-08 33.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA13005.1 - 5.2e-08 33.2 0.0 1.7e-07 31.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA13005.1 - 2.7e-07 29.8 0.0 4.5e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.13 ESA13005.1 - 3.4e-07 29.6 0.0 1.5e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.13 ESA13005.1 - 0.00044 19.5 0.0 0.017 14.3 0.0 2.0 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_26 PF13659.1 ESA13005.1 - 0.0012 18.8 0.0 0.0028 17.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 ESA13005.1 - 0.0044 15.4 0.0 0.023 13.0 0.0 1.8 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_9 PF08003.6 ESA13005.1 - 0.0064 15.2 0.0 0.0079 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_8 PF05148.10 ESA13005.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase FtsJ PF01728.14 ESA13005.1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.5 1 1 1 2 2 2 0 FtsJ-like methyltransferase MetW PF07021.7 ESA13005.1 - 0.027 13.8 0.0 0.039 13.3 0.0 1.3 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.9 ESA13005.1 - 0.071 12.4 0.0 0.11 11.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.14 ESA13005.1 - 0.078 12.4 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.13 ESA13005.1 - 0.083 12.0 0.0 0.084 12.0 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase Hom_end_hint PF05203.11 ESA13006.1 - 0.00026 20.7 0.1 0.0011 18.7 0.0 1.9 2 0 0 2 2 2 1 Hom_end-associated Hint SRP54 PF00448.17 ESA13006.1 - 0.049 13.0 0.0 0.079 12.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF162 PF02589.10 ESA13006.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised ACR, YkgG family COG1556 Kelch_4 PF13418.1 ESA13008.1 - 1.8e-27 94.8 8.1 3.1e-05 23.6 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA13008.1 - 8.8e-20 70.2 9.2 0.00014 21.7 0.2 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 ESA13008.1 - 5.8e-16 58.1 2.0 0.022 14.9 0.0 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA13008.1 - 9e-15 54.1 15.6 0.0051 16.9 0.2 6.5 4 1 2 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ESA13008.1 - 4.3e-12 45.3 2.4 0.038 13.5 0.2 5.1 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.10 ESA13008.1 - 0.0002 21.0 6.7 1.8 8.4 0.3 5.8 5 1 0 5 5 5 2 Kelch motif FYRC PF05965.9 ESA13010.1 - 0.01 15.6 0.1 0.19 11.5 0.1 2.6 1 1 0 1 1 1 0 F/Y rich C-terminus F-box-like PF12937.2 ESA13015.1 - 0.00062 19.4 2.3 0.00079 19.0 0.5 2.0 2 0 0 2 2 2 1 F-box-like Pkinase PF00069.20 ESA13016.1 - 5.9e-25 87.8 0.1 8.3e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13016.1 - 7.6e-25 87.4 0.0 8.8e-25 87.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_11 PF08241.7 ESA13017.1 - 1.2e-11 44.8 0.0 2.3e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA13017.1 - 3.2e-09 37.0 0.0 8.4e-09 35.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13017.1 - 5.7e-09 35.7 0.0 2.8e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA13017.1 - 7.3e-08 32.3 0.0 1.1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13017.1 - 5.1e-06 27.0 0.0 9.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA13017.1 - 1.7e-05 23.9 0.0 5.1e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA13017.1 - 7.1e-05 23.2 0.0 0.00013 22.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA13017.1 - 9.1e-05 22.4 0.0 0.00013 21.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA13017.1 - 0.00074 18.6 0.0 0.0071 15.4 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 ESA13017.1 - 0.04 13.2 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_29 PF03141.11 ESA13017.1 - 0.05 11.9 0.0 0.37 9.0 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase FtsJ PF01728.14 ESA13017.1 - 0.052 13.5 0.0 0.069 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase LSM PF01423.17 ESA13019.1 - 8.7e-18 63.6 0.1 1e-17 63.4 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESA13019.1 - 2.9e-06 27.0 0.0 3.5e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Snf7 PF03357.16 ESA13020.1 - 2.6e-37 127.8 14.5 2.6e-37 127.8 10.0 1.5 2 0 0 2 2 2 1 Snf7 DUF3936 PF13072.1 ESA13020.1 - 0.14 11.6 0.4 0.37 10.2 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3936) DUF4559 PF15112.1 ESA13020.1 - 4.2 6.4 10.1 6 5.9 7.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Ist1 PF03398.9 ESA13021.1 - 6.3e-66 220.8 2.3 8e-66 220.5 1.6 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF605 PF04652.11 ESA13021.1 - 0.003 16.9 2.7 0.0031 16.9 1.9 1.1 1 0 0 1 1 1 1 Vta1 like Cyto_heme_lyase PF01265.12 ESA13022.1 - 5e-81 272.1 2.3 5.8e-81 271.8 1.6 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase BsuPI PF12690.2 ESA13022.1 - 0.015 14.9 0.1 0.039 13.6 0.1 1.7 1 0 0 1 1 1 0 Intracellular proteinase inhibitor PALP PF00291.20 ESA13023.1 - 1.7e-60 204.8 0.0 2.1e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CitF PF04223.7 ESA13023.1 - 0.015 14.0 0.0 0.023 13.3 0.0 1.3 1 0 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) zf-CCHC PF00098.18 ESA13024.1 - 1.1e-14 53.5 15.7 5.4e-06 26.0 0.9 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.1 ESA13024.1 - 3.7e-08 32.7 8.9 0.0084 15.5 0.3 3.2 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.1 ESA13024.1 - 6.5e-06 25.7 15.3 0.022 14.4 1.0 3.1 3 0 0 3 3 3 3 Zinc knuckle DUF4206 PF13901.1 ESA13024.1 - 2 7.9 9.9 0.56 9.7 4.9 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) zf-CHC2 PF01807.15 ESA13024.1 - 2.3 7.8 8.4 4.1 7.0 0.4 2.6 1 1 1 2 2 2 0 CHC2 zinc finger IGFBP PF00219.13 ESA13024.1 - 5.8 7.5 10.4 82 3.8 7.2 2.2 1 1 0 1 1 1 0 Insulin-like growth factor binding protein TNFR_c6 PF00020.13 ESA13024.1 - 6.2 6.9 17.3 0.94 9.5 0.7 3.2 2 1 1 3 3 3 0 TNFR/NGFR cysteine-rich region DUF4210 PF13915.1 ESA13025.1 - 9.9e-23 80.2 0.0 2.6e-22 78.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.1 ESA13025.1 - 1.1e-20 73.2 0.0 2.3e-20 72.2 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis zf-C2H2 PF00096.21 ESA13026.1 - 1e-17 63.2 54.6 3.1e-05 24.0 0.5 7.3 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA13026.1 - 2.8e-17 61.6 46.4 0.0026 17.9 0.9 7.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA13026.1 - 1e-15 57.1 62.3 6.4e-05 23.0 0.4 7.6 8 0 0 8 8 8 5 Zinc-finger double domain zf-met PF12874.2 ESA13026.1 - 0.05 13.8 16.2 5.1 7.4 0.1 5.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA13026.1 - 0.76 9.7 20.3 0.41 10.6 0.3 5.6 6 0 0 6 6 6 0 C2H2-type zinc finger R3H PF01424.17 ESA13029.1 - 1.8e-13 49.9 0.1 4.7e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 R3H domain F-box-like PF12937.2 ESA13029.1 - 0.0026 17.4 0.1 0.0051 16.5 0.1 1.4 1 0 0 1 1 1 1 F-box-like Zip PF02535.17 ESA13029.1 - 4.1 6.3 5.0 5.7 5.8 3.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter BTB_2 PF02214.17 ESA13030.1 - 1.7e-20 72.9 0.6 1.1e-18 67.1 0.2 2.8 2 1 0 2 2 2 1 BTB/POZ domain RNA_POL_M_15KD PF02150.11 ESA13031.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit SPC12 PF06645.8 ESA13032.1 - 1e-25 89.3 0.3 1.2e-25 89.0 0.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) TPR_11 PF13414.1 ESA13033.1 - 6.1e-24 83.4 0.7 2.9e-11 42.8 0.0 5.7 4 1 2 6 6 6 4 TPR repeat TPR_2 PF07719.12 ESA13033.1 - 9.1e-15 53.3 8.2 0.00092 18.9 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESA13033.1 - 3.4e-14 51.7 10.8 0.001 18.5 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA13033.1 - 4.4e-11 43.1 0.0 1e-06 29.2 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA13033.1 - 3.5e-09 36.4 4.2 0.005 16.7 0.0 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA13033.1 - 1.7e-08 34.0 7.0 3e-05 23.8 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA13033.1 - 6.4e-08 32.5 0.0 0.0012 19.2 0.0 5.4 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA13033.1 - 1.6e-07 30.5 1.5 1.6 8.6 0.0 6.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA13033.1 - 2.4e-07 30.9 0.0 6.6e-05 23.1 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA13033.1 - 1e-06 28.0 0.3 0.0002 20.5 0.1 2.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA13033.1 - 0.0018 17.9 0.4 11 6.1 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA13033.1 - 0.0033 17.2 0.0 0.045 13.6 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA13033.1 - 0.044 14.2 0.4 47 4.7 0.0 5.5 7 0 0 7 7 7 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.7 ESA13035.1 - 1.3e-18 67.3 0.1 1.9e-11 43.9 0.0 2.1 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 ESA13035.1 - 2e-08 33.8 0.0 5e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_8 PF01501.15 ESA13035.1 - 0.0069 15.7 0.1 0.0099 15.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 ESA13035.1 - 0.059 13.1 1.5 0.18 11.5 1.0 1.7 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase BTB PF00651.26 ESA13036.1 - 0.11 12.4 0.1 3.6 7.6 0.1 2.1 1 1 0 1 1 1 0 BTB/POZ domain Dimer_Tnp_hAT PF05699.9 ESA13039.1 - 1.9e-15 56.2 0.0 2.1e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Methyltransf_25 PF13649.1 ESA13041.1 - 8.8e-08 32.4 0.0 1.5e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13041.1 - 1.3e-07 31.3 0.3 8.2e-07 28.7 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA13041.1 - 2.1e-07 31.3 0.0 3.7e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13041.1 - 4e-06 27.3 0.0 9.1e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ESA13041.1 - 1.7e-05 24.9 0.0 2.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 ESA13041.1 - 1.8e-05 24.5 0.0 1.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA13041.1 - 4.4e-05 22.9 0.0 6.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ESA13041.1 - 7.4e-05 21.8 0.0 0.00021 20.4 0.0 1.6 1 1 1 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA13041.1 - 0.00011 22.5 0.0 0.00049 20.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA13041.1 - 0.0017 18.3 0.0 0.0028 17.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESA13041.1 - 0.0067 15.5 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 ESA13041.1 - 0.07 12.2 0.0 0.14 11.2 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Pkinase_Tyr PF07714.12 ESA13042.1 - 2.7e-06 26.6 0.1 5.1e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13042.1 - 0.0028 16.8 0.1 0.0072 15.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Flagellar_rod PF05149.7 ESA13042.1 - 0.046 12.9 0.8 0.065 12.4 0.6 1.2 1 0 0 1 1 1 0 Paraflagellar rod protein NPIP PF06409.6 ESA13042.1 - 0.074 11.7 0.1 0.098 11.3 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) WLM PF08325.5 ESA13043.1 - 0.034 14.0 0.3 0.084 12.7 0.2 1.6 1 0 0 1 1 1 0 WLM domain DUF965 PF06135.7 ESA13044.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF965) Aldo_ket_red PF00248.16 ESA13045.1 - 5.1e-36 123.9 0.0 5.7e-36 123.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family JmjN PF02375.12 ESA13046.1 - 0.0093 15.4 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 1 jmjN domain FlaA PF04620.7 ESA13046.1 - 0.11 11.8 0.0 0.11 11.8 0.0 1.0 1 0 0 1 1 1 0 Flagellar filament outer layer protein Flaa ubiquitin PF00240.18 ESA13047.1 - 1e-28 98.4 0.5 1.2e-28 98.3 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA13047.1 - 3.2e-18 65.1 0.2 3.5e-18 65.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA13047.1 - 7.9e-05 22.8 0.1 0.00056 20.1 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ESA13047.1 - 0.00051 19.7 0.0 0.00059 19.5 0.0 1.0 1 0 0 1 1 1 1 Telomere stability and silencing Plexin_cytopl PF08337.7 ESA13047.1 - 0.087 11.1 0.8 1 7.5 0.2 1.9 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain RA PF00788.18 ESA13047.1 - 0.098 13.1 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain T4_deiodinase PF00837.12 ESA13048.1 - 1.5e-17 63.4 0.0 2.3e-17 62.7 0.0 1.4 1 1 0 1 1 1 1 Iodothyronine deiodinase TPR_14 PF13428.1 ESA13048.1 - 0.003 18.0 0.1 0.007 16.9 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2847 PF11009.3 ESA13048.1 - 0.02 14.4 0.0 1.6 8.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2847) TPR_19 PF14559.1 ESA13048.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BTB PF00651.26 ESA13052.1 - 1.5e-16 60.3 0.4 2.6e-16 59.5 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA13052.1 - 2.5e-13 50.1 2.3 8.2e-13 48.5 1.0 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA13052.1 - 4.4e-07 29.6 4.9 0.00031 20.5 0.2 4.0 2 1 1 3 3 3 2 BTB And C-terminal Kelch PDR_CDR PF06422.7 ESA13053.1 - 0.089 12.4 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 CDR ABC transporter GRP PF07172.6 ESA13053.1 - 0.14 12.6 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family MotB_plug PF13677.1 ESA13053.1 - 0.14 11.4 0.2 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB OAD_gamma PF04277.8 ESA13053.1 - 3.1 8.2 5.3 8.6 6.8 3.6 1.7 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TraG-D_C PF12696.2 ESA13055.1 - 0.036 13.9 0.0 0.047 13.5 0.0 1.1 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG F-box-like PF12937.2 ESA13056.1 - 0.00054 19.6 3.7 0.0023 17.5 0.7 2.4 2 0 0 2 2 2 1 F-box-like 7TM_transglut PF14402.1 ESA13058.1 - 0.023 13.6 2.1 0.032 13.1 1.5 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DUF1690 PF07956.6 ESA13060.1 - 0.021 14.8 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) PGP_phosphatase PF09419.5 ESA13061.1 - 0.028 13.7 0.1 0.049 12.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Kdo PF06293.9 ESA13063.1 - 7.3e-05 21.9 0.1 0.00013 21.0 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA13063.1 - 8.3e-05 21.8 0.1 0.00011 21.4 0.1 1.2 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA13063.1 - 0.045 13.4 0.3 0.056 13.1 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family APH_6_hur PF04655.9 ESA13063.1 - 0.049 12.7 0.6 0.063 12.4 0.4 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Prenyltrans PF00432.16 ESA13066.1 - 2.5e-26 90.8 0.0 1.2e-09 37.5 0.0 4.2 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESA13066.1 - 4.8e-13 49.5 0.0 3.5e-05 24.1 0.0 3.0 1 1 2 3 3 3 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESA13066.1 - 0.022 14.7 0.0 0.43 10.6 0.0 2.2 2 0 0 2 2 2 0 Prenyltransferase-like Dimer_Tnp_hAT PF05699.9 ESA13067.1 - 6e-17 61.0 0.0 6.5e-17 60.9 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Aldo_ket_red PF00248.16 ESA13071.1 - 2e-46 158.1 0.0 2.4e-46 157.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family RHH_3 PF12651.2 ESA13071.1 - 0.017 14.8 0.3 0.14 11.9 0.1 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF3782 PF12644.2 ESA13071.1 - 0.16 11.8 0.4 0.37 10.6 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) Aldo_ket_red PF00248.16 ESA13072.1 - 6.4e-25 87.5 0.1 7.8e-25 87.2 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family P22_AR_C PF10548.4 ESA13072.1 - 0.054 13.3 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 P22AR C-terminal domain Aldo_ket_red PF00248.16 ESA13073.1 - 3.3e-10 39.2 0.0 2.9e-08 32.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Pkinase_Tyr PF07714.12 ESA13074.1 - 3.8e-28 98.2 0.0 6.8e-28 97.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13074.1 - 1.7e-26 92.9 0.1 3.7e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA13074.1 - 0.00011 21.3 0.0 0.00017 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA13074.1 - 0.0032 16.8 0.2 0.008 15.5 0.1 1.6 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA13074.1 - 0.0033 17.1 0.1 0.0049 16.6 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA13074.1 - 0.04 12.9 0.1 0.06 12.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA13074.1 - 0.05 14.2 0.0 0.18 12.4 0.0 1.9 2 0 0 2 2 2 0 Sel1 repeat Pkinase PF00069.20 ESA13076.1 - 6.1e-69 232.0 0.0 1.4e-43 148.9 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13076.1 - 2e-37 128.6 0.0 4.8e-25 88.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESA13076.1 - 8.1e-06 24.9 0.0 0.00041 19.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA13076.1 - 7e-05 22.6 0.0 0.00094 18.9 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA13076.1 - 0.00017 20.7 0.0 0.00033 19.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA13076.1 - 0.0037 16.6 0.1 0.015 14.6 0.0 1.9 2 0 0 2 2 2 1 RIO1 family AFOR_N PF02730.10 ESA13076.1 - 0.071 12.4 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain Kelch_6 PF13964.1 ESA13078.1 - 1.4e-10 40.8 3.7 0.0044 17.1 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.20 ESA13078.1 - 1.6e-10 40.3 0.9 9.1e-05 21.9 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESA13078.1 - 3e-08 33.3 6.8 0.017 14.8 0.0 4.1 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA13078.1 - 8.4e-06 25.3 2.6 0.0017 18.0 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.1 ESA13078.1 - 0.011 15.8 10.6 0.023 14.8 0.0 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain CATSPERD PF15020.1 ESA13078.1 - 0.013 13.5 0.0 0.015 13.3 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit delta Kelch_5 PF13854.1 ESA13078.1 - 0.024 14.6 0.2 3 7.9 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Aldo_ket_red PF00248.16 ESA13079.1 - 2.3e-33 115.2 0.0 2.8e-33 114.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family P22_AR_C PF10548.4 ESA13079.1 - 0.05 13.4 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 P22AR C-terminal domain Sel1 PF08238.7 ESA13080.1 - 7.7e-155 499.9 72.9 2.4e-13 50.2 0.4 13.0 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA13080.1 - 1e-13 50.7 42.5 0.89 10.1 0.2 12.5 13 0 0 13 13 13 7 Tetratricopeptide repeat TPR_17 PF13431.1 ESA13080.1 - 6.8e-12 44.5 35.9 5.2 7.5 0.0 13.6 13 0 0 13 13 13 3 Tetratricopeptide repeat MIT PF04212.13 ESA13080.1 - 4e-10 39.4 57.1 1 9.3 0.1 12.5 11 2 2 13 13 13 6 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA13080.1 - 1.6e-08 34.1 18.2 40 4.0 0.0 12.0 13 0 0 13 13 13 0 Lung surfactant protein D coiled-coil trimerisation Flu_M1_C PF08289.6 ESA13080.1 - 0.0019 18.2 0.0 42 4.2 0.0 5.9 2 2 3 7 7 7 0 Influenza Matrix protein (M1) C-terminal domain TPR_20 PF14561.1 ESA13080.1 - 0.0027 17.7 3.1 18 5.5 0.0 5.4 2 2 3 6 6 6 0 Tetratricopeptide repeat CDO_I PF05995.7 ESA13080.1 - 0.0028 16.8 2.3 0.99 8.5 0.0 4.3 3 3 2 5 5 5 1 Cysteine dioxygenase type I HNH PF01844.18 ESA13080.1 - 0.0051 16.6 4.1 0.78 9.6 0.1 4.5 2 1 2 4 4 4 1 HNH endonuclease Peptidase_C14 PF00656.17 ESA13080.1 - 0.0073 16.0 0.0 11 5.6 0.0 4.8 1 1 1 2 2 2 0 Caspase domain DUF3674 PF12426.3 ESA13080.1 - 0.025 13.9 41.3 4.1 6.8 0.0 11.2 12 0 0 12 12 12 0 RNA dependent RNA polymerase DUF3574 PF12098.3 ESA13080.1 - 0.049 13.2 2.2 23 4.6 0.0 4.6 4 1 1 6 6 6 0 Protein of unknown function (DUF3574) 23S_rRNA_IVP PF05635.6 ESA13080.1 - 0.31 10.9 7.3 14 5.6 0.2 3.8 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein DCP1 PF06058.8 ESA13080.1 - 0.41 10.7 19.4 2.6 8.1 0.1 6.8 1 1 6 8 8 8 0 Dcp1-like decapping family tRNA-synt_1b PF00579.20 ESA13081.1 - 0.075 12.1 1.1 0.085 11.9 0.8 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) CLU_N PF15044.1 ESA13081.1 - 2.6 8.2 5.2 1.3 9.2 1.9 1.7 1 1 1 2 2 2 0 Mitochondrial function, CLU-N-term Alginate_lyase PF05426.7 ESA13082.1 - 1e-64 218.5 0.0 1.3e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 Alginate lyase Pkinase_Tyr PF07714.12 ESA13083.1 - 1.1e-34 119.6 0.0 1.7e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13083.1 - 9.2e-31 106.9 0.0 2.6e-30 105.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA13083.1 - 2.1e-05 23.6 0.0 3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA13083.1 - 0.0044 16.1 0.0 0.0069 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA13083.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Prenyltrans_2 PF13249.1 ESA13084.1 - 0.00019 21.8 7.5 5.5 7.4 0.1 6.2 3 2 3 6 6 6 4 Prenyltransferase-like Prenyltrans PF00432.16 ESA13084.1 - 0.017 14.7 0.0 0.6 9.7 0.0 3.5 4 0 0 4 4 4 0 Prenyltransferase and squalene oxidase repeat Pkinase_Tyr PF07714.12 ESA13086.1 - 5.9e-06 25.5 0.0 9.1e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13086.1 - 0.023 13.8 0.0 0.059 12.5 0.0 1.6 2 0 0 2 2 2 0 Protein kinase domain Cu-binding_MopE PF11617.3 ESA13086.1 - 0.93 9.3 3.5 2.9 7.7 1.0 2.6 2 0 0 2 2 2 0 Protein metal binding site Pkinase_Tyr PF07714.12 ESA13087.1 - 0.082 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Rap_GAP PF02145.10 ESA13088.1 - 2.7e-53 180.1 0.0 2.9e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Rap/ran-GAP AAA_22 PF13401.1 ESA13089.1 - 2.6e-05 24.3 0.1 8.7e-05 22.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA-ATPase_like PF09820.4 ESA13089.1 - 7.9e-05 21.9 0.7 0.00017 20.8 0.0 1.9 2 0 0 2 2 2 1 Predicted AAA-ATPase AAA PF00004.24 ESA13089.1 - 0.0053 16.9 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RGS PF00615.14 ESA13089.1 - 0.0057 16.7 0.2 0.21 11.6 0.0 2.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain Dynamin_N PF00350.18 ESA13089.1 - 0.035 13.9 0.1 0.37 10.5 0.0 2.5 2 0 0 2 2 2 0 Dynamin family Sigma54_activ_2 PF14532.1 ESA13089.1 - 0.055 13.5 0.0 4.6 7.2 0.0 2.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.1 ESA13089.1 - 0.11 12.5 0.1 1.5 8.8 0.0 2.6 2 1 1 3 3 3 0 AAA ATPase domain Rad1 PF02144.11 ESA13090.1 - 0.0046 15.7 0.0 0.0051 15.6 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 MASE1 PF05231.9 ESA13091.1 - 6.8 5.6 16.3 0.21 10.5 2.6 2.5 2 1 1 3 3 3 0 MASE1 Pox_A32 PF04665.7 ESA13092.1 - 4e-05 23.0 0.0 7.3e-05 22.1 0.0 1.5 1 1 0 1 1 1 1 Poxvirus A32 protein FtsK_SpoIIIE PF01580.13 ESA13092.1 - 0.0031 17.0 0.0 0.0058 16.1 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Miro PF08477.8 ESA13092.1 - 0.15 12.5 0.1 0.35 11.3 0.1 2.0 1 1 0 1 1 1 0 Miro-like protein Sel1 PF08238.7 ESA13095.1 - 2.9e-27 94.4 6.8 2.4e-09 37.5 0.1 3.0 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ESA13095.1 - 0.067 13.6 1.9 16 6.1 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA13095.1 - 0.15 11.7 10.1 1.7 8.3 1.3 3.0 1 1 1 2 2 2 0 TPR repeat Ribonuclease_3 PF00636.21 ESA13096.1 - 0.00023 21.6 0.1 0.00046 20.5 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease III domain DBD_Tnp_Mut PF03108.10 ESA13098.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 MuDR family transposase ATP_sub_h PF10775.4 ESA13099.1 - 1.5e-13 50.2 0.2 2.2e-13 49.7 0.1 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.6 ESA13099.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 RNA12 PF10443.4 ESA13100.1 - 6.3e-115 384.1 0.3 1.4e-113 379.6 0.2 2.1 1 1 0 1 1 1 1 RNA12 protein Arch_ATPase PF01637.13 ESA13100.1 - 1.6e-12 47.6 0.3 6.7e-12 45.6 0.2 2.1 1 1 0 1 1 1 1 Archaeal ATPase RRM_1 PF00076.17 ESA13100.1 - 1.7e-07 30.7 0.0 4.1e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA13100.1 - 1.2e-05 25.1 0.0 3e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MMR_HSR1 PF01926.18 ESA13100.1 - 1.3e-05 25.1 0.6 5.9e-05 23.0 0.4 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA13100.1 - 6.7e-05 22.1 0.0 0.00015 20.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 ESA13100.1 - 0.0001 22.3 0.0 0.00035 20.6 0.0 2.0 2 0 0 2 2 1 1 AAA ATPase domain ABC_tran PF00005.22 ESA13100.1 - 0.00011 22.4 0.0 0.00031 21.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter cobW PF02492.14 ESA13100.1 - 0.00034 20.0 0.3 0.0017 17.8 0.2 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 ESA13100.1 - 0.00063 19.8 0.0 0.0034 17.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain RRM_6 PF14259.1 ESA13100.1 - 0.00072 19.4 0.0 0.0025 17.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SMC_N PF02463.14 ESA13100.1 - 0.0021 17.3 0.1 0.012 14.8 0.0 2.0 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain KAP_NTPase PF07693.9 ESA13100.1 - 0.0028 16.7 0.0 0.0054 15.7 0.0 1.5 1 0 0 1 1 1 1 KAP family P-loop domain AAA_35 PF14516.1 ESA13100.1 - 0.0032 16.1 0.0 0.017 13.7 0.0 2.0 2 0 0 2 2 2 1 AAA-like domain AAA_14 PF13173.1 ESA13100.1 - 0.0052 16.6 0.0 0.017 15.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 ESA13100.1 - 0.0057 17.1 0.0 0.029 14.8 0.0 2.2 1 0 0 1 1 1 1 Miro-like protein Guanylate_kin PF00625.16 ESA13100.1 - 0.0073 15.7 0.1 0.04 13.3 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase AAA_29 PF13555.1 ESA13100.1 - 0.0075 15.7 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_33 PF13671.1 ESA13100.1 - 0.0076 16.1 0.0 0.023 14.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA13100.1 - 0.016 14.1 0.0 0.03 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_21 PF13304.1 ESA13100.1 - 0.022 14.7 2.1 0.032 14.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.11 ESA13100.1 - 0.025 13.7 0.1 0.076 12.1 0.0 1.8 1 0 0 1 1 1 0 AIG1 family DUF815 PF05673.8 ESA13100.1 - 0.027 13.4 0.0 0.048 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 ESA13100.1 - 0.031 14.4 0.0 0.34 11.1 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_10 PF12846.2 ESA13100.1 - 0.033 13.6 0.1 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain Zeta_toxin PF06414.7 ESA13100.1 - 0.045 12.8 0.0 0.097 11.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 ESA13100.1 - 0.049 13.2 0.1 0.18 11.4 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Dynamin_N PF00350.18 ESA13100.1 - 0.073 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Dynamin family Apc9 PF12856.2 ESA13100.1 - 0.085 12.9 2.2 0.19 11.8 0.4 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 9 AAA_23 PF13476.1 ESA13100.1 - 4.9 7.4 18.0 0.31 11.3 0.3 3.9 3 1 1 4 4 3 0 AAA domain DDOST_48kD PF03345.9 ESA13101.1 - 2.9e-141 470.8 1.9 3.6e-141 470.5 1.3 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta RNA12 PF10443.4 ESA13102.1 - 5.2e-74 249.2 1.9 7.1e-72 242.2 1.3 2.5 1 1 0 1 1 1 1 RNA12 protein Arch_ATPase PF01637.13 ESA13102.1 - 3.4e-11 43.2 0.1 3.4e-11 43.2 0.1 2.6 2 1 1 3 3 3 1 Archaeal ATPase RRM_5 PF13893.1 ESA13102.1 - 6.2e-07 29.1 0.0 1.9e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA13102.1 - 7.6e-07 28.6 0.0 2.2e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.1 ESA13102.1 - 0.00015 21.6 1.7 0.001 18.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.18 ESA13102.1 - 0.00029 20.7 0.6 0.0011 18.8 0.4 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA13102.1 - 0.0047 16.1 0.0 0.01 15.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA13102.1 - 0.014 14.5 0.3 0.05 12.7 0.0 2.1 2 0 0 2 2 2 0 AIG1 family AAA_22 PF13401.1 ESA13102.1 - 0.026 14.6 0.0 0.087 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA13102.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain T2SE PF00437.15 ESA13102.1 - 0.082 11.7 0.0 0.18 10.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.14 ESA13102.1 - 0.094 12.1 0.1 7.5 5.9 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF1049 PF06305.6 ESA13102.1 - 6.1 6.4 7.4 1.7 8.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1049) DHHA1 PF02272.14 ESA13103.1 - 6.6e-05 22.5 0.0 0.00016 21.3 0.0 1.6 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.15 ESA13103.1 - 0.0029 17.2 0.0 0.0069 16.0 0.0 1.6 1 0 0 1 1 1 1 DHH family DUF3588 PF12140.3 ESA13103.1 - 0.016 15.3 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3588) TPT PF03151.11 ESA13104.1 - 9.9e-38 129.1 11.7 9.9e-38 129.1 8.1 2.6 3 0 0 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 ESA13104.1 - 9.9e-08 31.2 26.5 1.6e-07 30.5 18.4 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESA13104.1 - 0.0002 21.3 14.3 0.0002 21.3 9.9 3.4 2 1 2 4 4 4 2 EamA-like transporter family Pkinase PF00069.20 ESA13106.1 - 2.2e-75 253.1 0.0 3.5e-75 252.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13106.1 - 2e-39 135.2 0.0 3.4e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA13106.1 - 9.6e-09 34.6 0.0 1.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA13106.1 - 0.0049 16.2 0.4 0.0095 15.2 0.3 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA13106.1 - 0.006 16.3 0.0 0.066 12.9 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA13106.1 - 0.0091 15.3 0.1 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA13106.1 - 0.021 13.9 0.0 0.034 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ANTH PF07651.11 ESA13107.1 - 3.5e-57 193.2 0.3 5.8e-57 192.5 0.2 1.3 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 ESA13107.1 - 7.6e-07 29.0 0.0 2.6e-06 27.3 0.0 1.9 1 0 0 1 1 1 1 ENTH domain APC_CDC26 PF10471.4 ESA13107.1 - 0.0085 16.8 4.1 0.0085 16.8 2.9 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex APC subunit 1 DUF1494 PF07379.6 ESA13107.1 - 0.045 13.6 1.6 0.86 9.4 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1494) CBF PF03914.12 ESA13108.1 - 9.7e-48 161.7 1.3 9.7e-48 161.7 0.9 2.7 3 0 0 3 3 3 1 CBF/Mak21 family MMR1 PF08505.5 ESA13109.1 - 0.042 13.8 1.1 0.12 12.4 0.7 1.8 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Sel1 PF08238.7 ESA13110.1 - 4.8e-60 198.6 5.6 5.3e-09 36.4 0.5 7.3 7 0 0 7 7 7 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA13110.1 - 5.7e-48 163.2 0.0 9.5e-48 162.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13110.1 - 9.1e-47 159.3 0.1 1.5e-46 158.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA13110.1 - 9e-05 21.5 0.0 0.0003 19.8 0.0 1.8 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA13110.1 - 0.00046 19.5 0.8 0.0012 18.1 0.2 2.0 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA13110.1 - 0.0014 17.7 0.0 0.0024 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AdoMet_MTase PF07757.8 ESA13110.1 - 0.0084 16.2 2.2 2.3 8.3 0.0 4.5 3 2 2 5 5 5 1 Predicted AdoMet-dependent methyltransferase APH PF01636.18 ESA13110.1 - 0.0098 15.6 0.5 0.021 14.5 0.3 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family TPR_6 PF13174.1 ESA13110.1 - 0.01 16.2 7.1 4.8 7.8 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat YrbL-PhoP_reg PF10707.4 ESA13110.1 - 0.013 14.8 0.2 0.03 13.6 0.2 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL MIT PF04212.13 ESA13110.1 - 0.018 14.9 5.9 0.8 9.6 0.7 3.7 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA13110.1 - 0.13 11.9 16.3 0.77 9.4 0.2 4.6 1 1 4 5 5 5 0 TPR repeat MinE PF03776.9 ESA13110.1 - 0.18 11.3 2.0 0.44 10.0 1.4 1.6 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE TLD PF07534.11 ESA13111.1 - 8.1e-11 42.0 2.3 8.1e-11 42.0 1.6 1.7 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA13111.1 - 2.9e-08 33.6 0.1 6e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13111.1 - 2.1e-05 24.2 0.7 0.00017 21.3 0.0 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch SURF2 PF05477.6 ESA13113.1 - 0.008 15.3 8.5 0.013 14.6 5.9 1.3 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) DUF4379 PF14311.1 ESA13114.1 - 6.3e-05 22.7 5.2 0.0041 16.8 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4379) zf-CGNR PF11706.3 ESA13114.1 - 0.16 11.5 1.9 0.3 10.6 0.7 2.0 2 0 0 2 2 2 0 CGNR zinc finger GF_recep_IV PF14843.1 ESA13114.1 - 0.61 9.7 6.5 0.86 9.2 4.5 1.3 1 1 0 1 1 1 0 Growth factor receptor domain IV Kinesin PF00225.18 ESA13115.1 - 2.1e-66 223.9 0.0 4.2e-66 222.9 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA13115.1 - 0.032 13.1 0.0 0.053 12.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3896 PF13035.1 ESA13116.1 - 0.001 19.0 1.4 0.0016 18.4 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3896) DUF4618 PF15397.1 ESA13116.1 - 0.02 14.2 0.1 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) BRAP2 PF07576.7 ESA13119.1 - 1.7e-26 91.9 0.0 4.4e-26 90.6 0.0 1.8 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 ESA13119.1 - 1.2e-19 70.1 5.0 2.9e-19 68.9 3.5 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 ESA13119.1 - 2.4e-08 33.6 9.5 2.4e-08 33.6 6.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 ESA13119.1 - 0.00011 21.7 7.4 0.00025 20.6 5.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA13119.1 - 0.0004 20.4 4.1 0.0004 20.4 2.8 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA13119.1 - 0.00084 19.3 8.4 0.00084 19.3 5.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA13119.1 - 0.0014 18.2 6.1 0.0014 18.2 4.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA13119.1 - 0.0037 16.9 5.2 0.011 15.3 1.4 2.8 2 0 0 2 2 2 1 RING-type zinc-finger V_ATPase_I PF01496.14 ESA13119.1 - 0.19 9.5 10.2 0.32 8.8 7.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TerY-C PF15616.1 ESA13119.1 - 0.25 11.2 13.9 0.059 13.3 2.3 2.8 1 1 1 2 2 2 0 TerY-C metal binding domain zf-RING_4 PF14570.1 ESA13119.1 - 0.26 10.8 6.5 0.075 12.6 1.9 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain APG6 PF04111.7 ESA13119.1 - 0.47 9.4 16.4 1.5 7.8 11.4 1.8 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF342 PF03961.8 ESA13119.1 - 0.51 8.6 12.4 0.87 7.9 8.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF3450 PF11932.3 ESA13119.1 - 1.2 8.3 16.5 0.21 10.8 4.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) zf-Apc11 PF12861.2 ESA13119.1 - 2 8.3 14.7 0.12 12.1 4.3 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger IncA PF04156.9 ESA13119.1 - 2.2 7.8 23.2 11 5.6 16.1 2.0 1 1 0 1 1 1 0 IncA protein L31 PF09784.4 ESA13119.1 - 4.5 7.3 10.1 6.2 6.9 3.3 2.9 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 DUF948 PF06103.6 ESA13119.1 - 5.9 6.8 8.7 6.1 6.7 1.8 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HNH_5 PF14279.1 ESA13120.1 - 0.0056 16.6 0.2 0.0067 16.3 0.2 1.1 1 0 0 1 1 1 1 HNH endonuclease zf-BED PF02892.10 ESA13120.1 - 0.065 13.0 0.9 0.082 12.6 0.6 1.2 1 0 0 1 1 1 0 BED zinc finger CAP_GLY PF01302.20 ESA13121.1 - 6.8e-25 86.5 2.9 1.1e-24 85.8 2.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 ESA13121.1 - 4e-22 78.2 0.0 6.8e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.18 ESA13121.1 - 0.00012 21.3 0.0 0.00054 19.3 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family DM13 PF10517.4 ESA13123.1 - 0.0024 18.2 0.1 0.0037 17.6 0.0 1.3 1 0 0 1 1 1 1 Electron transfer DM13 Pkinase_Tyr PF07714.12 ESA13124.1 - 2.8e-05 23.3 0.0 3.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13124.1 - 0.02 14.0 0.0 0.029 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DnaB_2 PF07261.6 ESA13124.1 - 0.064 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Replication initiation and membrane attachment Pkinase_Tyr PF07714.12 ESA13125.1 - 0.00084 18.4 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13125.1 - 0.025 13.7 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain BTB PF00651.26 ESA13127.1 - 1.6e-18 66.7 0.7 3.5e-18 65.6 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA13127.1 - 0.00029 20.8 0.2 0.00029 20.8 0.1 2.5 2 1 0 2 2 2 1 TLD F-box-like PF12937.2 ESA13128.1 - 2.4e-06 27.1 0.1 2.7e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13128.1 - 0.011 15.3 0.1 0.035 13.7 0.1 1.9 1 1 0 1 1 1 0 F-box domain DnaB_2 PF07261.6 ESA13128.1 - 0.1 12.2 0.3 0.12 11.9 0.2 1.1 1 0 0 1 1 1 0 Replication initiation and membrane attachment LRR_8 PF13855.1 ESA13129.1 - 0.012 15.3 0.7 0.014 15.1 0.5 1.1 1 0 0 1 1 1 0 Leucine rich repeat CBM27 PF09212.5 ESA13130.1 - 0.036 14.0 0.1 0.065 13.2 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate binding module 27 TcdB_N PF12918.2 ESA13131.1 - 0.056 13.5 1.8 0.062 13.3 0.4 1.7 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Exo_endo_phos_2 PF14529.1 ESA13133.1 - 0.061 12.9 0.0 0.061 12.9 0.0 2.9 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase DUF749 PF05370.6 ESA13134.1 - 0.083 12.8 0.8 0.32 10.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF749) Ribosomal_L6 PF00347.18 ESA13136.1 - 2.9e-21 75.7 0.1 1.1e-15 57.8 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 TLP-20 PF06088.6 ESA13137.1 - 0.013 15.2 1.4 0.015 14.9 1.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Amidinotransf PF02274.12 ESA13137.1 - 0.017 14.2 0.4 0.018 14.1 0.2 1.1 1 0 0 1 1 1 0 Amidinotransferase OSTbeta PF15048.1 ESA13137.1 - 0.13 12.3 1.4 0.18 11.8 1.0 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein HMG_box PF00505.14 ESA13138.1 - 0.00092 19.4 0.6 0.0017 18.5 0.4 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA13138.1 - 0.097 13.0 0.3 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 HMG-box domain HMG_box_2 PF09011.5 ESA13139.1 - 6.4e-08 32.8 0.7 9.6e-08 32.2 0.5 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA13139.1 - 2.3e-07 30.9 2.6 6.8e-07 29.4 1.7 1.7 1 1 1 2 2 2 1 HMG (high mobility group) box DUF1074 PF06382.6 ESA13139.1 - 0.00032 20.7 0.6 0.00036 20.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1074) HSP70 PF00012.15 ESA13140.1 - 1.6e-06 26.3 0.0 0.0002 19.4 0.0 2.7 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA13140.1 - 6.9e-06 24.8 0.0 0.0025 16.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Peptidase_M22 PF00814.20 ESA13140.1 - 0.011 15.1 0.0 0.069 12.6 0.0 2.0 2 0 0 2 2 2 0 Glycoprotease family VWA_2 PF13519.1 ESA13141.1 - 1.8e-16 60.7 0.3 1.4e-13 51.3 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain TLD PF07534.11 ESA13141.1 - 1.7e-14 54.0 2.7 2.2e-14 53.6 0.9 1.9 2 0 0 2 2 2 1 TLD VWA PF00092.23 ESA13141.1 - 3.2e-07 30.2 1.3 4.2e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 ESA13141.1 - 0.0037 16.4 0.9 0.86 8.6 0.2 2.2 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.4 ESA13141.1 - 0.026 14.3 0.3 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 vWA found in TerF C terminus EF1G PF00647.14 ESA13142.1 - 0.068 12.8 2.4 0.089 12.5 1.7 1.2 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain BPD_transp_2 PF02653.11 ESA13143.1 - 0.0068 15.4 0.1 0.025 13.5 0.0 1.7 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component VASP_tetra PF08776.6 ESA13143.1 - 0.025 13.8 5.1 0.046 13.0 2.4 2.0 2 0 0 2 2 2 0 VASP tetramerisation domain Syndecan PF01034.15 ESA13143.1 - 0.16 11.6 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 Syndecan domain Orthopox_B11R PF07033.6 ESA13143.1 - 0.68 9.4 6.1 0.18 11.2 1.5 2.0 1 1 0 2 2 2 0 Orthopoxvirus B11R protein P12 PF12669.2 ESA13143.1 - 1.1 9.5 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 Virus attachment protein p12 family VASP_tetra PF08776.6 ESA13144.1 - 0.019 14.2 5.5 0.045 13.0 2.7 2.1 2 0 0 2 2 2 0 VASP tetramerisation domain Helicase_C PF00271.26 ESA13147.1 - 3.3e-27 94.1 0.1 8.4e-26 89.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA13147.1 - 5.4e-27 94.3 0.0 2.7e-19 69.2 0.0 3.5 3 1 1 4 4 4 2 DEAD/DEAH box helicase Helicase_C_2 PF13307.1 ESA13147.1 - 0.013 15.4 0.0 0.064 13.2 0.0 2.1 3 0 0 3 3 3 0 Helicase C-terminal domain SecA_DEAD PF07517.9 ESA13147.1 - 0.033 13.4 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain zf-CCHC PF00098.18 ESA13147.1 - 0.044 13.7 2.7 0.083 12.8 1.9 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESA13147.1 - 0.056 13.1 0.8 0.12 12.1 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle BACK PF07707.10 ESA13148.1 - 2.1e-06 27.5 0.2 1.4e-05 24.8 0.1 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Tetraspannin PF00335.15 ESA13150.1 - 0.006 15.8 5.8 0.006 15.8 4.0 1.9 1 1 1 2 2 2 2 Tetraspanin family Vma12 PF11712.3 ESA13150.1 - 1.5 8.5 6.7 0.33 10.6 1.6 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Noelin-1 PF12308.3 ESA13151.1 - 0.16 11.7 0.3 0.33 10.7 0.1 1.6 1 1 0 1 1 1 0 Neurogenesis glycoprotein TIMELESS PF04821.9 ESA13154.1 - 1.4e-11 44.2 7.7 3.9e-11 42.7 5.3 1.7 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.8 ESA13154.1 - 2.1e-08 33.5 0.8 3.8e-08 32.7 0.5 1.4 1 0 0 1 1 1 1 Timeless protein C terminal region Pkinase_Tyr PF07714.12 ESA13156.1 - 1.4e-12 47.2 0.0 1.9e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13156.1 - 3.6e-10 39.4 0.3 4.9e-10 39.0 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain TLD PF07534.11 ESA13157.1 - 1e-15 57.9 0.7 2.2e-15 56.8 0.5 1.6 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA13157.1 - 4.1e-07 29.9 1.5 5.5e-06 26.3 0.0 2.7 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA13157.1 - 0.00029 20.6 3.5 0.0044 16.8 0.7 2.8 1 1 2 3 3 3 1 BTB And C-terminal Kelch Thioredoxin_4 PF13462.1 ESA13158.1 - 0.084 12.8 0.6 0.11 12.4 0.4 1.1 1 0 0 1 1 1 0 Thioredoxin DUF3335 PF11814.3 ESA13158.1 - 0.49 9.4 2.0 0.67 9.0 1.4 1.2 1 0 0 1 1 1 0 Peptidase_C39 like family Striatin PF08232.7 ESA13158.1 - 8.1 6.7 15.4 1.1 9.5 5.2 2.1 1 1 1 2 2 2 0 Striatin family Sel1 PF08238.7 ESA13159.1 - 3.6e-84 275.3 54.2 1.8e-11 44.2 0.4 11.0 10 1 0 10 10 10 9 Sel1 repeat TPR_6 PF13174.1 ESA13159.1 - 4.1e-07 30.0 11.5 3 8.4 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat Pkinase PF00069.20 ESA13159.1 - 7.5e-07 28.5 0.1 5.1e-06 25.8 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13159.1 - 2.5e-06 26.7 0.0 3.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_16 PF13432.1 ESA13159.1 - 0.0093 16.6 6.2 2.9 8.6 0.1 4.9 3 2 2 5 5 5 1 Tetratricopeptide repeat DUF2433 PF10360.4 ESA13160.1 - 0.094 13.0 0.6 0.15 12.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) TLD PF07534.11 ESA13161.1 - 2.5e-07 30.7 3.0 3.7e-07 30.2 2.1 1.3 1 1 0 1 1 1 1 TLD TLD PF07534.11 ESA13162.1 - 1.1e-10 41.5 0.8 3.2e-10 40.1 0.6 1.9 1 1 0 1 1 1 1 TLD AMP-binding PF00501.23 ESA13164.1 - 8.7e-06 24.3 0.0 9.5e-06 24.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Pkinase PF00069.20 ESA13165.1 - 2e-10 40.2 0.1 2.7e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13165.1 - 5.2e-08 32.2 0.0 9.8e-08 31.3 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase NCA2 PF08637.5 ESA13166.1 - 0.015 14.1 0.0 0.015 14.1 0.0 1.0 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 Myb_DNA-binding PF00249.26 ESA13167.1 - 3.3e-09 36.6 0.8 6.4e-09 35.7 0.6 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA13167.1 - 3.6e-08 33.3 1.9 4.6e-08 33.0 0.2 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain DDE_2 PF02914.10 ESA13167.1 - 0.009 15.5 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage Mu transposase UvrB PF12344.3 ESA13167.1 - 6.1 6.4 6.4 6.1 6.4 0.1 3.2 3 0 0 3 3 3 0 Ultra-violet resistance protein B Pkinase_Tyr PF07714.12 ESA13168.1 - 2.2e-18 66.2 0.0 2.4e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13168.1 - 2.2e-15 56.5 0.0 2.3e-15 56.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Ubiquitin_2 PF14560.1 ESA13170.1 - 0.065 13.5 0.0 0.68 10.2 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain F-box-like PF12937.2 ESA13171.1 - 0.018 14.7 1.3 0.018 14.7 0.9 2.4 2 0 0 2 2 2 0 F-box-like AAA PF00004.24 ESA13172.1 - 5.7e-06 26.5 0.5 0.00022 21.4 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA13172.1 - 1.7e-05 24.5 0.0 4.1e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESA13172.1 - 6e-05 23.2 0.7 0.0047 17.0 0.0 3.5 3 1 1 4 4 4 1 AAA domain Miro PF08477.8 ESA13172.1 - 0.00072 20.0 0.0 0.0026 18.2 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AAA_14 PF13173.1 ESA13172.1 - 0.00073 19.4 0.1 0.0036 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA13172.1 - 0.0037 17.4 0.3 0.033 14.3 0.1 2.8 2 1 0 2 2 2 1 RNA helicase Viral_helicase1 PF01443.13 ESA13172.1 - 0.011 15.2 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 ESA13172.1 - 0.019 14.6 0.6 0.18 11.4 0.0 2.9 3 0 0 3 3 3 0 NACHT domain DUF258 PF03193.11 ESA13172.1 - 0.04 13.0 0.0 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Sigma54_activ_2 PF14532.1 ESA13172.1 - 0.042 13.9 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 Sigma-54 interaction domain BTB PF00651.26 ESA13173.1 - 9.2e-19 67.4 0.2 1.5e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13173.1 - 8.9e-05 22.2 2.5 0.00024 20.9 0.7 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA13173.1 - 0.022 13.9 1.0 0.024 13.7 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Skp1 PF01466.14 ESA13173.1 - 0.04 13.9 0.3 0.11 12.5 0.1 1.8 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Urm1 PF09138.6 ESA13173.1 - 0.2 11.8 1.4 0.81 9.8 1.0 2.1 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) BTB PF00651.26 ESA13174.1 - 4.7e-12 45.8 0.0 1.2e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13174.1 - 0.00088 19.0 5.3 0.0011 18.7 1.2 2.5 1 1 0 2 2 2 1 BTB And C-terminal Kelch Pentapeptide_3 PF13576.1 ESA13175.1 - 0.027 14.3 1.2 0.027 14.3 0.8 1.8 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.1 ESA13175.1 - 0.088 12.6 0.8 0.21 11.4 0.6 1.6 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Big_5 PF13205.1 ESA13176.1 - 4.4e-06 27.2 4.5 4.4e-06 27.2 3.1 2.1 2 0 0 2 2 2 1 Bacterial Ig-like domain CopC PF04234.7 ESA13176.1 - 0.016 15.7 0.3 0.04 14.5 0.0 1.8 2 0 0 2 2 2 0 CopC domain WD40 PF00400.27 ESA13178.1 - 3.7e-09 36.1 16.0 6e-05 22.7 0.1 4.8 4 1 1 5 5 5 3 WD domain, G-beta repeat DUF4360 PF14273.1 ESA13178.1 - 0.00015 21.4 1.7 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4360) Rib_recp_KP_reg PF05104.7 ESA13178.1 - 0.22 12.0 6.6 0.41 11.1 4.6 1.4 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Peptidase_S49_N PF08496.5 ESA13178.1 - 0.27 11.0 1.9 0.4 10.4 1.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3139 PF11337.3 ESA13178.1 - 1.5 9.1 6.2 4.9 7.5 4.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) DDE_1 PF03184.14 ESA13179.1 - 6.3e-11 41.8 0.1 6.3e-11 41.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF624 PF04854.9 ESA13179.1 - 0.13 12.0 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF624 DUF226 PF02890.9 ESA13183.1 - 0.039 13.7 1.0 0.98 9.1 0.2 2.2 1 1 1 2 2 2 0 Borrelia family of unknown function DUF226 Sel1 PF08238.7 ESA13185.1 - 2.5e-09 37.4 0.1 0.00014 22.3 0.0 2.4 2 0 0 2 2 2 2 Sel1 repeat Corona_nucleoca PF00937.13 ESA13185.1 - 0.0012 17.8 8.8 0.0018 17.2 6.1 1.2 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein Ndc1_Nup PF09531.5 ESA13185.1 - 0.068 11.5 5.9 0.086 11.2 4.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup THRAP3_BCLAF1 PF15440.1 ESA13185.1 - 0.4 9.2 16.8 0.56 8.7 11.6 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Macoilin PF09726.4 ESA13185.1 - 2 6.6 10.5 2.5 6.2 7.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Pkinase PF00069.20 ESA13186.1 - 7e-27 94.2 0.2 8.4e-27 93.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13186.1 - 1.6e-25 89.6 0.1 2e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA13187.1 - 8e-08 32.6 0.0 1.5e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Sel1 repeat Pkinase PF00069.20 ESA13188.1 - 5.4e-11 42.1 0.0 6e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13188.1 - 5.5e-08 32.1 0.0 6.1e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L28 PF00830.14 ESA13189.1 - 3.3e-22 78.0 0.1 3.8e-22 77.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28 family Kelch_2 PF07646.10 ESA13191.1 - 5.9 6.8 6.6 4.7 7.1 0.2 2.7 2 1 0 2 2 2 0 Kelch motif PCNA_N PF00705.13 ESA13194.1 - 1.7e-57 192.3 0.5 3.2e-57 191.5 0.3 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 ESA13194.1 - 4.4e-50 168.8 0.2 6.6e-50 168.3 0.1 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.8 ESA13194.1 - 3.5e-08 32.8 0.1 4e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 HOOK PF05622.7 ESA13195.1 - 0.014 13.2 12.1 0.016 13.0 8.4 1.0 1 0 0 1 1 1 0 HOOK protein DivIC PF04977.10 ESA13195.1 - 0.039 13.4 1.1 0.039 13.4 0.8 2.4 2 0 0 2 2 2 0 Septum formation initiator PilJ PF13675.1 ESA13195.1 - 0.064 13.5 7.7 0.21 11.9 2.2 2.1 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term PSII_Pbs27 PF13326.1 ESA13195.1 - 0.073 13.0 1.0 0.088 12.7 0.4 1.5 2 0 0 2 2 2 0 Photosystem II Pbs27 DUF3573 PF12097.3 ESA13195.1 - 0.15 10.6 1.3 0.16 10.5 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) FliD_N PF02465.13 ESA13195.1 - 0.19 12.0 6.1 4.6 7.6 1.2 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ArdA PF07275.6 ESA13195.1 - 0.25 11.5 6.3 0.96 9.6 4.4 1.9 1 1 0 1 1 1 0 Antirestriction protein (ArdA) MbeD_MobD PF04899.7 ESA13195.1 - 0.29 11.0 13.7 1.3 8.9 0.1 3.2 2 1 1 3 3 3 0 MbeD/MobD like LXG PF04740.7 ESA13195.1 - 0.31 10.7 9.0 0.39 10.4 0.4 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily SPX PF03105.14 ESA13195.1 - 0.69 9.6 11.2 1.1 9.0 7.8 1.3 1 0 0 1 1 1 0 SPX domain FliD_C PF07195.7 ESA13195.1 - 0.78 8.9 7.1 1.6 8.0 0.7 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus YkyA PF10368.4 ESA13195.1 - 1.1 8.6 10.5 0.33 10.2 3.8 2.0 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Prefoldin_3 PF13758.1 ESA13195.1 - 1.5 8.6 9.1 4.8 7.0 1.1 2.3 2 0 0 2 2 2 0 Prefoldin subunit GrpE PF01025.14 ESA13195.1 - 2.9 7.4 10.3 1 8.8 3.0 2.3 2 0 0 2 2 2 0 GrpE Phage_Mu_Gam PF07352.7 ESA13195.1 - 3.1 7.3 8.4 7 6.1 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Snapin_Pallidin PF14712.1 ESA13195.1 - 3.1 8.1 7.6 0.36 11.1 1.0 2.1 2 0 0 2 2 2 0 Snapin/Pallidin CENP-Q PF13094.1 ESA13195.1 - 4.7 7.2 9.0 4.7 7.2 2.9 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4047 PF13256.1 ESA13195.1 - 7.8 6.4 8.6 2.9 7.8 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) SAE2 PF08573.5 ESA13196.1 - 1.7e-13 51.0 2.5 1.7e-13 51.0 1.8 3.7 3 2 0 3 3 3 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Mst1_SARAH PF11629.3 ESA13197.1 - 0.095 12.5 0.4 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 P_C PF06640.6 ESA13197.1 - 0.62 10.0 4.0 0.16 11.9 0.2 1.9 2 0 0 2 2 2 0 P protein C-terminus Cylicin_N PF15241.1 ESA13198.1 - 0.027 14.3 0.4 0.027 14.3 0.3 1.8 2 0 0 2 2 2 0 Cylicin N-terminus DUF3295 PF11702.3 ESA13198.1 - 0.03 13.3 5.4 0.039 12.9 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Mucin PF01456.12 ESA13198.1 - 0.37 10.5 16.6 0.5 10.1 11.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Pkinase PF00069.20 ESA13199.1 - 0.0018 17.4 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain FTA2 PF13095.1 ESA13199.1 - 0.0059 16.2 0.6 0.0059 16.2 0.4 1.0 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 PI31_Prot_N PF11566.3 ESA13200.1 - 8.9e-27 93.5 0.0 1.2e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.6 ESA13200.1 - 8.2e-12 45.6 17.3 8.2e-12 45.6 12.0 2.3 2 0 0 2 2 2 1 PI31 proteasome regulator Mso1_C PF14477.1 ESA13200.1 - 0.028 14.7 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 Membrane-polarising domain of Mso1 Rrp15p PF07890.7 ESA13201.1 - 1.7e-27 96.0 6.3 1.7e-27 96.0 4.4 2.2 1 1 1 2 2 2 1 Rrp15p KapB PF08810.5 ESA13201.1 - 5.2 7.1 7.7 2.2 8.3 1.3 2.3 2 1 0 2 2 2 0 Kinase associated protein B Pkinase PF00069.20 ESA13202.1 - 5.3e-14 52.0 0.6 5.6e-14 51.9 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13202.1 - 2.7e-06 26.6 0.4 2.9e-06 26.5 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase NIF PF03031.13 ESA13206.1 - 0.076 12.6 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase zf-CCHC PF00098.18 ESA13207.1 - 4.5e-07 29.4 0.4 7.2e-07 28.8 0.3 1.3 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 ESA13207.1 - 2.1e-06 27.6 0.6 1.4e-05 25.1 0.0 2.7 3 0 0 3 3 3 1 Retrotransposon gag protein Hemagglutinin PF00509.13 ESA13209.1 - 0.014 13.5 0.2 0.022 12.9 0.1 1.2 1 0 0 1 1 1 0 Haemagglutinin DUF4265 PF14085.1 ESA13209.1 - 0.083 12.6 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) F-box-like PF12937.2 ESA13211.1 - 1e-06 28.3 3.2 2.8e-06 26.9 0.2 2.8 2 0 0 2 2 2 1 F-box-like F-box-like_2 PF13013.1 ESA13211.1 - 0.098 12.3 3.6 0.11 12.2 0.6 2.5 2 1 0 2 2 2 0 F-box-like domain Av_adeno_fibre PF06536.6 ESA13211.1 - 1.7 8.3 5.7 0.95 9.2 0.2 2.9 2 1 1 3 3 3 0 Avian adenovirus fibre BTB PF00651.26 ESA13213.1 - 2e-14 53.5 0.0 5e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA13213.1 - 3.8e-12 46.3 1.2 8.3e-12 45.2 0.9 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA13213.1 - 6.4e-05 22.7 1.8 0.033 14.0 0.1 3.5 1 1 2 3 3 3 2 BTB And C-terminal Kelch Pkinase PF00069.20 ESA13214.1 - 1.2e-26 93.4 0.1 1.3e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13214.1 - 8.1e-25 87.3 0.0 9.3e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA13214.1 - 0.00053 19.0 0.0 0.00061 18.8 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA13214.1 - 0.015 14.3 0.1 0.019 14.0 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA13215.1 - 7.7e-99 321.9 18.5 1.1e-13 51.3 0.9 11.0 11 0 0 11 11 11 10 Sel1 repeat MIT PF04212.13 ESA13215.1 - 0.04 13.8 21.5 23 4.9 0.1 7.4 5 3 2 7 7 7 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA13215.1 - 1.7 9.3 17.6 25 5.6 0.5 8.0 10 1 0 10 10 10 0 Tetratricopeptide repeat NSF PF02071.15 ESA13215.1 - 9.6 7.2 13.9 1.9e+02 3.4 0.0 7.0 7 0 0 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat DUF3169 PF11368.3 ESA13218.1 - 0.16 11.1 0.1 0.18 11.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4502 PF14950.1 ESA13218.1 - 0.25 10.4 2.1 0.26 10.3 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) DUF3823 PF12866.2 ESA13219.1 - 0.039 13.4 0.1 0.042 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3823) Pyrid_oxidase_2 PF13883.1 ESA13220.1 - 1.8e-16 60.3 0.9 2.4e-16 59.9 0.6 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase F-box-like PF12937.2 ESA13221.1 - 6e-05 22.6 0.1 0.0012 18.4 0.1 2.9 2 0 0 2 2 2 1 F-box-like Rft-1 PF04506.8 ESA13222.1 - 4.4e-86 289.4 20.4 5.5e-86 289.0 14.1 1.0 1 0 0 1 1 1 1 Rft protein Piwi PF02171.12 ESA13223.1 - 1.3e-78 264.0 1.8 2.3e-78 263.2 1.2 1.4 1 0 0 1 1 1 1 Piwi domain DUF3695 PF12494.3 ESA13223.1 - 0.0066 16.1 2.2 1 9.0 0.1 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF3695) DUF4080 PF13311.1 ESA13223.1 - 0.083 12.9 0.9 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4080) zf-MYND PF01753.13 ESA13225.1 - 5.6e-22 77.3 36.1 2.5e-11 43.2 10.7 2.5 2 0 0 2 2 2 2 MYND finger Beta_helix PF13229.1 ESA13225.1 - 2.5e-19 69.5 23.4 3.5e-10 39.8 3.0 3.0 3 0 0 3 3 3 2 Right handed beta helix region DUF4470 PF14737.1 ESA13225.1 - 2.9e-12 46.1 0.0 6.5e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) Ecl1 PF12855.2 ESA13225.1 - 0.49 9.7 17.8 1.2 8.4 2.3 2.6 2 0 0 2 2 2 0 Life-span regulatory factor DUF4206 PF13901.1 ESA13228.1 - 2 7.8 8.9 2.2 7.8 0.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4206) BTB PF00651.26 ESA13229.1 - 4.6e-16 58.7 0.4 8e-16 58.0 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA13229.1 - 9.3e-12 45.1 0.4 8.8e-11 41.9 0.2 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA13229.1 - 3.8e-06 26.6 0.3 0.00066 19.4 0.0 3.6 2 1 2 4 4 4 1 BTB And C-terminal Kelch ARPC4 PF05856.7 ESA13230.1 - 0.015 14.6 0.2 0.066 12.6 0.0 1.9 2 0 0 2 2 2 0 ARP2/3 complex 20 kDa subunit (ARPC4) Pkinase_Tyr PF07714.12 ESA13232.1 - 1.6e-11 43.7 0.0 2.7e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13232.1 - 2.1e-09 36.9 0.0 5e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain SprT-like PF10263.4 ESA13232.1 - 0.0039 16.8 14.7 0.74 9.4 0.8 4.2 4 0 0 4 4 4 2 SprT-like family zinc_ribbon_2 PF13240.1 ESA13232.1 - 5 6.7 24.9 0.69 9.4 0.2 4.8 4 0 0 4 4 4 0 zinc-ribbon domain zf-DBF PF07535.7 ESA13232.1 - 6.8 6.4 22.6 3.4 7.4 1.7 4.6 4 0 0 4 4 4 0 DBF zinc finger Ion_trans PF00520.26 ESA13236.1 - 1.6e-09 37.3 8.0 2.6e-09 36.6 5.5 1.3 1 0 0 1 1 1 1 Ion transport protein DnaI_N PF07319.6 ESA13237.1 - 0.0059 16.8 2.0 0.0059 16.8 1.4 2.9 4 0 0 4 4 4 1 Primosomal protein DnaI N-terminus Phage_int_SAM_4 PF13495.1 ESA13237.1 - 0.008 16.4 1.3 0.038 14.3 0.1 2.5 1 1 1 2 2 2 1 Phage integrase, N-terminal SAM-like domain Pkinase_Tyr PF07714.12 ESA13238.1 - 2.4e-32 112.0 0.0 3.9e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13238.1 - 6e-30 104.2 0.0 8.6e-30 103.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA13238.1 - 0.0032 16.5 0.0 0.0046 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family GPP34 PF05719.6 ESA13239.1 - 2.9e-54 184.2 0.0 3.5e-54 184.0 0.0 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Dpoe2NT PF12213.3 ESA13239.1 - 0.035 14.0 0.2 0.56 10.1 0.0 2.5 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal Tash_PEST PF07708.6 ESA13240.1 - 0.64 10.0 4.8 14 5.7 1.6 2.5 2 0 0 2 2 2 0 Tash protein PEST motif Nop14 PF04147.7 ESA13241.1 - 0.068 11.0 0.0 0.11 10.3 0.0 1.3 1 1 0 1 1 1 0 Nop14-like family FYRC PF05965.9 ESA13244.1 - 6.2e-18 64.3 0.0 1.2e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.9 ESA13244.1 - 7.2e-17 60.5 0.2 1.1e-16 59.9 0.1 1.3 1 0 0 1 1 1 1 F/Y-rich N-terminus ABC2_membrane PF01061.19 ESA13245.1 - 1.5e-38 132.0 15.1 1.5e-38 132.0 10.5 2.0 3 0 0 3 3 2 1 ABC-2 type transporter ABC_tran PF00005.22 ESA13245.1 - 9.3e-27 93.9 0.0 2.4e-26 92.6 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 ESA13245.1 - 9.5e-09 35.6 0.0 3.3e-08 33.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 ESA13245.1 - 1.1e-05 24.8 0.0 0.0079 15.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 ESA13245.1 - 3.9e-05 22.8 21.8 3.9e-05 22.8 15.1 2.3 2 1 0 2 2 2 1 ABC-2 family transporter protein DUF258 PF03193.11 ESA13245.1 - 0.0088 15.2 0.4 0.024 13.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function, DUF258 hEGF PF12661.2 ESA13245.1 - 0.011 15.7 22.7 0.064 13.3 0.6 4.7 4 0 0 4 4 4 0 Human growth factor-like EGF AAA_29 PF13555.1 ESA13245.1 - 0.012 15.1 0.1 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 ESA13245.1 - 0.047 13.5 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 ESA13245.1 - 0.081 11.9 0.0 4.7 6.1 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain AAA_18 PF13238.1 ESA13245.1 - 0.082 13.2 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESA13245.1 - 0.11 12.2 0.2 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.1 ESA13245.1 - 0.11 12.4 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA13245.1 - 0.12 12.4 0.1 0.38 10.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain SbcCD_C PF13558.1 ESA13245.1 - 0.16 11.9 0.0 0.52 10.2 0.0 1.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FliD_C PF07195.7 ESA13245.1 - 0.16 11.1 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus MobB PF03205.9 ESA13245.1 - 0.19 11.4 0.1 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B UPF0079 PF02367.12 ESA13245.1 - 0.21 11.2 0.2 0.46 10.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 FGGY_C PF02782.11 ESA13246.1 - 6.5e-23 81.3 0.0 5.1e-22 78.4 0.0 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 ESA13246.1 - 6.2e-22 78.0 0.0 1.7e-19 70.1 0.0 2.3 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain HSP70 PF00012.15 ESA13246.1 - 0.00044 18.2 0.1 0.00068 17.6 0.1 1.2 1 0 0 1 1 1 1 Hsp70 protein TLD PF07534.11 ESA13247.1 - 1.3e-39 135.4 0.1 2.8e-39 134.2 0.0 1.6 2 0 0 2 2 2 1 TLD SNARE_assoc PF09335.6 ESA13248.1 - 9.2e-20 71.0 8.7 9.2e-20 71.0 6.0 2.3 3 1 0 3 3 3 1 SNARE associated Golgi protein Amnionless PF14828.1 ESA13248.1 - 0.048 12.1 1.4 0.16 10.4 0.1 2.0 2 0 0 2 2 2 0 Amnionless DUF912 PF06024.7 ESA13248.1 - 0.093 12.7 0.3 0.093 12.7 0.2 3.4 3 1 1 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Viral_Beta_CD PF04530.7 ESA13248.1 - 0.11 12.7 1.9 9.3 6.4 0.0 3.2 2 1 1 3 3 3 0 Viral Beta C/D like family PAZ PF02170.17 ESA13249.1 - 0.027 13.7 0.7 0.03 13.6 0.5 1.1 1 0 0 1 1 1 0 PAZ domain TLD PF07534.11 ESA13250.1 - 5.7e-09 36.0 1.3 1.8e-08 34.4 0.9 1.9 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA13250.1 - 1.1e-08 34.8 2.8 3.6e-06 26.7 0.3 2.8 1 1 1 2 2 2 2 BTB And C-terminal Kelch GerE PF00196.14 ESA13251.1 - 0.23 10.8 1.9 0.37 10.1 0.4 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family DUF310 PF03750.8 ESA13251.1 - 0.45 10.7 2.3 8.8 6.5 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF310) Methyltransf_11 PF08241.7 ESA13252.1 - 7e-05 23.2 0.0 9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA13252.1 - 0.0011 19.2 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA13252.1 - 0.0084 15.2 0.0 0.0099 15.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family zf-CCHC PF00098.18 ESA13255.1 - 0.0025 17.6 4.3 0.0055 16.5 3.0 1.6 1 0 0 1 1 1 1 Zinc knuckle LRR_4 PF12799.2 ESA13256.1 - 2.4e-51 170.6 78.5 1.2e-09 37.5 0.5 12.8 6 2 3 12 12 12 10 Leucine Rich repeats (2 copies) PP2C PF00481.16 ESA13256.1 - 2.5e-48 164.6 0.0 4.9e-48 163.7 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.1 ESA13256.1 - 1.4e-44 149.6 77.2 6e-09 35.5 1.1 10.7 7 2 4 12 12 12 9 Leucine rich repeat Guanylate_cyc PF00211.15 ESA13256.1 - 5.4e-29 100.8 0.0 1e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 ESA13256.1 - 1e-26 88.8 76.7 0.0015 18.2 0.3 20.5 21 0 0 21 21 21 10 Leucine Rich Repeat LRR_7 PF13504.1 ESA13256.1 - 2.3e-12 44.9 74.8 0.13 12.5 0.1 19.1 21 0 0 21 21 21 7 Leucine rich repeat RA PF00788.18 ESA13256.1 - 4.4e-10 39.9 0.0 1.1e-09 38.6 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain LRR_6 PF13516.1 ESA13256.1 - 1.1e-05 25.0 64.6 1 9.6 0.3 16.2 15 1 2 17 17 17 4 Leucine Rich repeat P16-Arc PF04699.9 ESA13257.1 - 6.8e-18 65.1 0.1 7.6e-18 64.9 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) BRX_N PF13713.1 ESA13257.1 - 0.16 11.4 0.2 0.28 10.6 0.1 1.4 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain Prion_bPrPp PF11587.3 ESA13258.1 - 0.051 13.2 1.4 5.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal Pkinase_Tyr PF07714.12 ESA13259.1 - 2.5e-37 128.3 0.0 3.6e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13259.1 - 3.3e-32 111.6 0.0 5.3e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Tissue_fac PF01108.12 ESA13259.1 - 0.035 13.8 4.2 0.72 9.6 0.0 2.9 3 0 0 3 3 3 0 Tissue factor E1-E2_ATPase PF00122.15 ESA13260.1 - 2.7e-24 85.4 0.0 2.7e-24 85.4 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 ESA13260.1 - 2.9e-17 63.7 0.0 8.8e-17 62.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA13260.1 - 2.1e-11 44.3 0.4 7.1e-11 42.6 0.3 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA13260.1 - 8e-07 28.9 0.0 2.8e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESA13260.1 - 0.0004 20.0 0.2 0.0014 18.2 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TPR_11 PF13414.1 ESA13261.1 - 0.024 14.2 0.5 0.84 9.3 0.0 2.7 2 1 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 ESA13261.1 - 0.06 13.2 0.9 14 5.9 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat MAP65_ASE1 PF03999.7 ESA13262.1 - 0.0014 17.3 1.2 0.0017 17.0 0.8 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Pkinase_Tyr PF07714.12 ESA13263.1 - 0.042 12.9 0.1 0.11 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Nucleoporin_N PF08801.6 ESA13265.1 - 0.02 13.6 0.3 0.023 13.4 0.2 1.0 1 0 0 1 1 1 0 Nup133 N terminal like Pkinase PF00069.20 ESA13267.1 - 2.6e-34 118.5 0.0 4.7e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13267.1 - 1.1e-32 113.1 0.0 1.5e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA13267.1 - 0.12 11.4 0.2 0.23 10.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EntA_Immun PF08951.5 ESA13267.1 - 0.5 10.5 5.8 4.2 7.5 0.2 2.9 2 0 0 2 2 2 0 Enterocin A Immunity Serinc PF03348.10 ESA13270.1 - 9.4e-109 363.9 21.9 6.4e-76 255.7 7.6 3.0 1 1 2 3 3 3 3 Serine incorporator (Serinc) DUF3246 PF11596.3 ESA13270.1 - 0.00017 20.9 0.4 0.00023 20.5 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) HIG_1_N PF04588.8 ESA13270.1 - 0.14 11.9 3.0 0.9 9.3 0.3 3.2 2 0 0 2 2 2 0 Hypoxia induced protein conserved region ABC2_membrane_5 PF13346.1 ESA13270.1 - 9.9 5.3 31.7 0.2 10.9 6.2 3.0 3 0 0 3 3 3 0 ABC-2 family transporter protein DSBA PF01323.15 ESA13271.1 - 9.4e-54 181.9 0.0 9.2e-31 106.9 0.0 2.3 2 1 0 2 2 2 2 DSBA-like thioredoxin domain DNA_Packaging PF11053.3 ESA13272.1 - 0.042 13.4 0.4 0.047 13.3 0.3 1.2 1 0 0 1 1 1 0 Terminase DNA packaging enzyme BBE PF08031.7 ESA13275.1 - 3.5e-07 30.0 0.4 9e-07 28.7 0.3 1.7 1 0 0 1 1 1 1 Berberine and berberine like RRM_1 PF00076.17 ESA13276.1 - 3.1e-38 129.2 0.1 6.7e-18 64.1 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA13276.1 - 6.2e-32 109.3 0.0 1e-15 57.4 0.0 2.0 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA13276.1 - 7.9e-12 44.8 0.0 5.8e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA13276.1 - 0.00079 19.2 0.0 0.84 9.5 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif OB_RNB PF08206.6 ESA13276.1 - 0.064 12.7 0.1 7.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain 7TM_GPCR_Srbc PF10316.4 ESA13277.1 - 0.042 13.1 0.2 0.064 12.5 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2405 PF10293.4 ESA13279.1 - 0.013 15.2 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2405) TLD PF07534.11 ESA13280.1 - 3e-12 46.7 0.3 5e-12 45.9 0.2 1.4 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA13280.1 - 3e-09 36.8 0.5 9.9e-09 35.1 0.2 1.9 1 1 1 2 2 2 1 BTB/POZ domain DUF3909 PF13077.1 ESA13280.1 - 0.033 14.0 0.4 0.13 12.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3909) BACK PF07707.10 ESA13280.1 - 0.07 12.9 0.1 22 4.9 0.0 3.3 3 0 0 3 3 3 0 BTB And C-terminal Kelch TLD PF07534.11 ESA13281.1 - 0.00024 21.1 3.0 0.00042 20.3 2.1 1.4 1 1 0 1 1 1 1 TLD PI31_Prot_N PF11566.3 ESA13283.1 - 0.027 14.0 6.2 0.031 13.8 1.9 2.3 2 1 0 2 2 2 0 PI31 proteasome regulator N-terminal HMA PF00403.21 ESA13284.1 - 4e-16 58.8 1.3 4.7e-16 58.6 0.9 1.0 1 0 0 1 1 1 1 Heavy-metal-associated domain NapD PF03927.8 ESA13284.1 - 0.014 15.1 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 NapD protein CdhC PF03598.10 ESA13284.1 - 0.026 13.0 0.0 0.027 12.9 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit WD40 PF00400.27 ESA13285.1 - 1.1e-20 72.6 22.2 2.5e-06 27.1 0.9 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat 60KD_IMP PF02096.15 ESA13286.1 - 2.7e-33 115.3 4.8 4.1e-33 114.7 3.3 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Pro_isomerase PF00160.16 ESA13287.1 - 1.1e-47 162.1 0.6 1.6e-47 161.5 0.4 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 ESA13287.1 - 1.8e-17 62.7 4.4 8.3e-11 41.3 0.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA13287.1 - 6.8e-12 44.4 4.8 6.9e-05 22.2 0.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA13287.1 - 1.6e-11 43.1 0.8 0.00066 19.3 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA13287.1 - 3.5e-05 23.6 0.7 0.016 15.1 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA13287.1 - 0.00071 19.1 3.7 0.06 13.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA13287.1 - 0.0015 18.8 0.3 0.32 11.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA13287.1 - 0.0026 17.5 0.0 0.079 12.8 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA13287.1 - 0.0028 17.7 2.5 0.018 15.1 0.3 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESA13287.1 - 0.0096 16.4 0.1 0.29 11.8 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA13287.1 - 0.1 13.2 0.5 3.6 8.3 0.3 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat AFG1_ATPase PF03969.11 ESA13288.1 - 1.1e-105 353.3 0.2 1.4e-100 336.6 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.1 ESA13288.1 - 6.7e-05 22.9 0.4 0.0018 18.3 0.3 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ESA13288.1 - 0.0004 20.2 0.0 0.0014 18.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 ESA13288.1 - 0.0026 17.4 0.0 0.091 12.4 0.0 2.9 2 1 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 ESA13288.1 - 0.0065 16.2 0.3 0.2 11.3 0.0 2.7 2 1 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 ESA13288.1 - 0.0069 16.5 0.1 0.085 12.9 0.0 2.6 1 1 0 2 2 2 1 AAA domain AAA PF00004.24 ESA13288.1 - 0.01 16.0 0.0 0.046 13.9 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.13 ESA13288.1 - 0.024 14.3 2.0 0.074 12.6 0.3 2.4 2 1 0 2 2 2 0 Bacterial dnaA protein DUF87 PF01935.12 ESA13288.1 - 0.024 14.4 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 UvrD-helicase PF00580.16 ESA13288.1 - 0.067 12.4 0.1 0.22 10.8 0.0 1.8 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.9 ESA13288.1 - 0.079 12.6 0.0 0.25 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 ESA13288.1 - 0.082 13.0 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.1 ESA13288.1 - 0.11 11.9 0.0 0.31 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Thiolase_N PF00108.18 ESA13289.1 - 4.8e-91 304.3 0.4 1.2e-90 303.1 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 ESA13289.1 - 3.7e-45 152.3 0.6 6.7e-45 151.4 0.4 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 ESA13289.1 - 1.5e-05 24.6 0.2 3.2e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Med13_N PF11597.3 ESA13290.1 - 0.00096 17.9 0.2 0.0076 14.9 0.1 2.0 1 1 1 2 2 2 2 Mediator complex subunit 13 N-terminal EF-hand_7 PF13499.1 ESA13291.1 - 1e-25 89.6 19.7 4e-10 39.6 2.3 5.3 3 2 3 6 6 6 5 EF-hand domain pair EF-hand_1 PF00036.27 ESA13291.1 - 2.3e-25 85.9 25.5 4.6e-07 28.6 0.8 7.4 8 0 0 8 8 8 5 EF hand EF-hand_6 PF13405.1 ESA13291.1 - 2.7e-24 82.7 18.7 1.6e-05 24.3 0.7 7.6 8 0 0 8 8 8 5 EF-hand domain EF-hand_5 PF13202.1 ESA13291.1 - 2.2e-20 71.0 21.2 4.8e-06 25.6 0.4 5.8 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 ESA13291.1 - 4.2e-15 55.0 22.8 1.4e-06 27.8 0.2 7.1 7 1 1 8 8 8 4 EF-hand domain pair EF-hand_4 PF12763.2 ESA13291.1 - 8.4e-08 31.9 15.1 0.2 11.4 0.1 6.1 2 2 4 6 6 6 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA13291.1 - 1.2e-07 31.7 5.6 0.00053 19.9 0.1 3.7 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 ESA13291.1 - 0.0014 18.2 12.4 0.46 10.1 0.1 5.3 5 1 1 6 6 6 2 EF hand Gag_p10 PF02337.12 ESA13291.1 - 0.066 12.9 0.0 0.22 11.2 0.0 2.0 1 0 0 1 1 1 0 Retroviral GAG p10 protein Erf4 PF10256.4 ESA13291.1 - 0.1 12.4 0.7 4 7.3 0.0 2.5 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Swi5 PF07061.6 ESA13291.1 - 1.7 8.5 6.0 8.3 6.2 0.1 3.8 3 0 0 3 3 3 0 Swi5 p25-alpha PF05517.7 ESA13291.1 - 6.2 7.0 15.6 11 6.1 0.2 4.2 3 2 0 3 3 3 0 p25-alpha SET PF00856.23 ESA13292.1 - 2.7e-21 76.5 0.1 1.4e-20 74.2 0.1 2.2 1 1 0 1 1 1 1 SET domain GATA PF00320.22 ESA13292.1 - 6.7e-07 28.5 3.5 2.5e-06 26.7 2.4 2.0 1 0 0 1 1 1 1 GATA zinc finger Prp31_C PF09785.4 ESA13292.1 - 0.056 13.8 0.1 0.27 11.6 0.0 2.1 2 0 0 2 2 2 0 Prp31 C terminal domain SIN1 PF05422.7 ESA13293.1 - 1.8e-58 198.3 0.4 2.2e-58 198.0 0.3 1.2 1 0 0 1 1 1 1 Stress-activated map kinase interacting protein 1 (SIN1) TUG-UBL1 PF11470.3 ESA13293.1 - 0.014 15.2 0.1 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 GLUT4 regulating protein TUG RA PF00788.18 ESA13293.1 - 0.022 15.2 0.1 2.1 8.9 0.0 2.9 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Ras PF00071.17 ESA13294.1 - 6.2e-60 201.2 0.7 7.3e-60 201.0 0.5 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.16 ESA13294.1 - 9.4e-21 73.8 0.2 1.1e-20 73.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 ESA13294.1 - 7.5e-20 71.6 0.1 1.1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESA13294.1 - 1.6e-09 37.7 0.0 2.2e-09 37.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA13294.1 - 8.3e-09 35.1 0.1 4.5e-08 32.7 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESA13294.1 - 8.9e-09 34.8 0.1 1e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESA13294.1 - 8.5e-05 21.8 0.2 0.00025 20.3 0.1 1.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 ESA13294.1 - 0.0012 18.1 0.0 0.0027 16.9 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_22 PF13401.1 ESA13294.1 - 0.011 15.8 0.0 1.1 9.4 0.0 2.4 1 1 0 1 1 1 0 AAA domain PRP8_domainIV PF12134.3 ESA13294.1 - 0.034 13.4 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 PRP8 domain IV core Tfb2 PF03849.9 ESA13294.1 - 0.035 12.7 0.2 0.044 12.4 0.1 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 Dynamin_N PF00350.18 ESA13294.1 - 0.038 13.7 0.1 0.11 12.3 0.0 1.9 1 1 0 1 1 1 0 Dynamin family AAA_16 PF13191.1 ESA13294.1 - 0.066 13.2 0.0 2.8 7.8 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain DUF258 PF03193.11 ESA13294.1 - 0.071 12.2 0.1 0.18 10.9 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 ESA13294.1 - 0.086 12.3 0.0 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 ESA13294.1 - 0.093 12.2 0.3 3.4 7.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 ESA13294.1 - 0.097 12.9 0.1 0.23 11.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 ESA13294.1 - 0.14 11.7 0.1 0.38 10.3 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PDZ_2 PF13180.1 ESA13295.1 - 1.1e-08 34.8 0.1 2e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 ESA13295.1 - 1.6e-05 24.9 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.19 ESA13295.1 - 0.0019 18.3 0.0 0.0041 17.2 0.0 1.6 1 1 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) YlqD PF11068.3 ESA13295.1 - 0.11 12.5 2.1 0.25 11.3 1.5 1.6 1 1 0 1 1 1 0 YlqD protein HMG_box PF00505.14 ESA13296.1 - 4.6e-10 39.6 0.9 7.6e-10 38.9 0.6 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA13296.1 - 6.6e-07 29.6 0.5 7.7e-07 29.3 0.4 1.1 1 0 0 1 1 1 1 HMG-box domain DUF4247 PF14042.1 ESA13296.1 - 0.06 13.3 0.0 0.078 12.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4247) Med26 PF08711.6 ESA13296.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 TFIIS helical bundle-like domain DPCD PF14913.1 ESA13297.1 - 0.065 12.3 3.4 0.023 13.7 0.7 1.5 2 1 0 2 2 2 0 DPCD protein family Sigma54_AID PF00309.15 ESA13297.1 - 0.27 10.7 4.2 2 7.9 0.4 2.5 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) ASC PF00858.19 ESA13301.1 - 0.068 11.8 0.7 0.087 11.4 0.5 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel DUF2542 PF10808.3 ESA13302.1 - 0.12 12.6 0.3 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2542) Mitofilin PF09731.4 ESA13303.1 - 6.3 5.3 6.1 7.2 5.1 4.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Bcl-2_BAD PF10514.4 ESA13304.1 - 0.0033 17.3 0.0 0.0047 16.8 0.0 1.3 1 0 0 1 1 1 1 Pro-apoptotic Bcl-2 protein, BAD DNA_pol_B_2 PF03175.8 ESA13305.1 - 2e-05 23.4 2.1 0.00028 19.6 1.0 2.1 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral Endonuclease_7 PF02945.10 ESA13305.1 - 0.042 13.5 0.0 0.042 13.5 0.0 2.2 2 1 0 2 2 2 0 Recombination endonuclease VII Mg_trans_NIPA PF05653.9 ESA13309.1 - 3e-15 55.9 3.8 5.3e-15 55.1 2.6 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 ESA13309.1 - 6.2e-07 29.6 8.0 9.2e-07 29.0 5.5 1.2 1 0 0 1 1 1 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA13309.1 - 0.00022 21.2 10.1 0.0003 20.8 7.0 1.1 1 0 0 1 1 1 1 EamA-like transporter family UPF0546 PF10639.4 ESA13309.1 - 0.0073 16.1 1.9 0.0073 16.1 1.3 1.6 2 0 0 2 2 2 1 Uncharacterised protein family UPF0546 BatD PF13584.1 ESA13309.1 - 0.0091 14.6 0.2 0.012 14.1 0.1 1.1 1 0 0 1 1 1 1 Oxygen tolerance UPF0060 PF02694.10 ESA13309.1 - 0.11 12.5 2.3 0.23 11.5 1.6 1.4 1 0 0 1 1 1 0 Uncharacterised BCR, YnfA/UPF0060 family RBP_receptor PF14752.1 ESA13309.1 - 0.13 10.5 4.9 0.17 10.1 3.4 1.2 1 0 0 1 1 1 0 Retinol binding protein receptor RDD PF06271.7 ESA13310.1 - 0.092 12.6 0.9 0.11 12.3 0.6 1.1 1 0 0 1 1 1 0 RDD family Rap1_C PF11626.3 ESA13312.1 - 0.076 12.9 0.2 0.076 12.9 0.2 1.8 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UAA PF08449.6 ESA13313.1 - 6.6e-86 287.9 18.7 8e-86 287.6 13.0 1.0 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 ESA13313.1 - 0.0056 16.8 3.9 0.0056 16.8 2.7 2.9 3 2 0 3 3 3 1 Multidrug resistance efflux transporter F-box-like PF12937.2 ESA13314.1 - 2.8e-07 30.1 1.5 7.3e-07 28.8 1.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13314.1 - 0.0068 16.0 1.2 0.12 12.0 0.2 3.3 2 1 0 2 2 2 1 F-box domain MMR_HSR1 PF01926.18 ESA13315.1 - 5.6e-11 42.4 0.4 6.7e-10 38.9 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA13315.1 - 0.0002 20.8 0.4 0.011 15.2 0.1 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESA13315.1 - 0.0015 17.8 0.8 0.033 13.4 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Ras PF00071.17 ESA13315.1 - 0.0017 17.7 0.1 0.59 9.4 0.0 2.3 2 0 0 2 2 2 2 Ras family DUF258 PF03193.11 ESA13315.1 - 0.013 14.7 0.1 0.099 11.8 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function, DUF258 Miro PF08477.8 ESA13315.1 - 0.019 15.4 0.0 0.85 10.1 0.0 2.6 2 0 0 2 2 2 0 Miro-like protein MobB PF03205.9 ESA13315.1 - 0.02 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AIG1 PF04548.11 ESA13315.1 - 0.12 11.4 0.2 0.5 9.4 0.0 2.2 3 0 0 3 3 3 0 AIG1 family AAA_32 PF13654.1 ESA13315.1 - 0.14 10.7 0.1 0.22 10.1 0.1 1.1 1 0 0 1 1 1 0 AAA domain Mpp10 PF04006.7 ESA13318.1 - 0.86 7.8 18.9 1.1 7.5 13.1 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.9 ESA13318.1 - 1 7.3 9.4 1.2 7.0 6.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.8 ESA13318.1 - 1.9 6.5 17.9 2.1 6.3 12.4 1.1 1 0 0 1 1 1 0 Utp14 protein Pox_Ag35 PF03286.9 ESA13318.1 - 2.8 7.4 14.0 5.8 6.3 9.7 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.12 ESA13318.1 - 3 6.5 5.5 5 5.8 3.8 1.4 1 0 0 1 1 1 0 Presenilin Orbi_VP6 PF01516.11 ESA13318.1 - 4.4 6.2 12.0 6.4 5.7 8.3 1.2 1 0 0 1 1 1 0 Orbivirus helicase VP6 Pkinase PF00069.20 ESA13320.1 - 1.3e-38 132.6 0.5 2.5e-24 85.8 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13320.1 - 4.7e-38 130.7 0.0 2.5e-26 92.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 ESA13320.1 - 4e-06 26.0 0.0 0.0002 20.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA13320.1 - 0.0071 16.1 0.2 0.016 14.9 0.2 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA13320.1 - 0.0073 15.6 0.7 0.026 13.8 0.5 1.8 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA13320.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TLD PF07534.11 ESA13322.1 - 6.6e-11 42.3 2.0 1e-10 41.7 0.4 2.0 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA13322.1 - 2.6e-05 24.0 0.6 0.00037 20.2 0.1 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch PCYCGC PF13798.1 ESA13323.1 - 0.083 12.5 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif Pkinase PF00069.20 ESA13325.1 - 5e-41 140.5 0.2 6.2e-41 140.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13325.1 - 9.1e-41 139.6 0.1 1.1e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA13325.1 - 9.1e-06 24.8 0.0 2.1e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA13325.1 - 0.00078 18.8 0.1 0.0013 18.1 0.1 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA13325.1 - 0.001 18.8 0.1 0.0094 15.7 0.2 2.2 1 1 2 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA13325.1 - 0.002 17.4 2.6 0.0029 16.9 0.1 2.0 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA13325.1 - 0.0021 17.1 0.0 0.0034 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HXXEE PF13787.1 ESA13326.1 - 0.0018 18.6 9.4 0.0018 18.6 6.5 2.6 2 1 0 2 2 2 1 Protein of unknown function with HXXEE motif WTF PF03303.8 ESA13326.1 - 0.12 11.7 3.8 0.18 11.1 2.6 1.3 1 0 0 1 1 1 0 WTF protein He_PIG_assoc PF10632.4 ESA13327.1 - 0.074 12.3 0.3 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 He_PIG associated, NEW1 domain of bacterial glycohydrolase DUF1785 PF08699.5 ESA13328.1 - 0.014 14.7 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1785) LRR_4 PF12799.2 ESA13329.1 - 4.3 7.0 11.0 3.9 7.2 0.0 5.2 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) DUF3684 PF12449.3 ESA13331.1 - 1.3e-73 248.2 0.1 1.9e-73 247.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) WLM PF08325.5 ESA13331.1 - 0.1 12.4 1.3 0.23 11.3 0.9 1.5 1 0 0 1 1 1 0 WLM domain Neur_chan_memb PF02932.11 ESA13332.1 - 0.56 10.0 5.1 0.9 9.3 3.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PPR_2 PF13041.1 ESA13334.1 - 0.003 17.4 0.1 1.7 8.6 0.0 3.0 3 0 0 3 3 3 2 PPR repeat family LRR_4 PF12799.2 ESA13335.1 - 0.02 14.4 1.3 0.67 9.6 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Asp_protease PF09668.5 ESA13337.1 - 0.048 13.2 0.2 0.07 12.6 0.2 1.3 1 0 0 1 1 1 0 Aspartyl protease RVP_2 PF08284.6 ESA13337.1 - 0.074 12.9 0.2 0.089 12.7 0.1 1.1 1 0 0 1 1 1 0 Retroviral aspartyl protease MYT1 PF08474.6 ESA13337.1 - 0.4 10.1 3.0 0.12 11.7 0.5 1.4 2 0 0 2 2 2 0 Myelin transcription factor 1 Response_reg PF00072.19 ESA13338.1 - 4.2e-27 94.3 0.8 9.6e-24 83.5 0.1 2.7 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.21 ESA13338.1 - 7.7e-27 93.2 0.2 1.8e-26 92.0 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 ESA13338.1 - 1e-14 54.2 0.1 3.1e-14 52.7 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain OATP PF03137.15 ESA13338.1 - 0.037 12.0 1.3 0.21 9.6 0.1 2.1 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CCDC155 PF14662.1 ESA13338.1 - 0.046 13.3 3.5 0.099 12.2 2.4 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Pkinase_Tyr PF07714.12 ESA13339.1 - 6.9e-37 126.9 0.0 1.1e-36 126.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13339.1 - 2.9e-34 118.3 0.5 5.8e-34 117.4 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA13339.1 - 0.00055 19.3 0.5 0.0011 18.3 0.1 1.7 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA13339.1 - 0.00071 18.6 0.0 0.001 18.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA13339.1 - 0.0021 17.1 0.3 0.006 15.6 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA13339.1 - 0.0043 16.8 0.0 0.0079 15.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family UCR_UQCRX_QCR9 PF05365.7 ESA13339.1 - 0.0049 16.4 0.1 0.0095 15.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like WaaY PF06176.6 ESA13339.1 - 0.0075 15.5 0.1 0.017 14.3 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) HeLo PF14479.1 ESA13339.1 - 0.051 13.3 0.1 0.075 12.7 0.1 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation RAI16-like PF10257.4 ESA13340.1 - 2.4e-78 263.5 0.5 4.5e-78 262.6 0.4 1.4 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein ORC6 PF05460.8 ESA13340.1 - 0.013 14.6 8.3 0.025 13.6 5.8 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Macoilin PF09726.4 ESA13340.1 - 2.2 6.4 8.0 3.5 5.8 5.5 1.2 1 0 0 1 1 1 0 Transmembrane protein NifU_N PF01592.11 ESA13341.1 - 9.6e-53 177.4 0.0 1.2e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain PI-PLC-X PF00388.14 ESA13342.1 - 1.3e-62 209.5 0.0 3.5e-62 208.1 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 ESA13342.1 - 5.2e-47 158.6 0.7 1.9e-46 156.8 0.5 2.0 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.25 ESA13342.1 - 9.9e-17 60.5 0.0 3e-16 59.0 0.0 1.9 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.6 ESA13342.1 - 9e-11 41.6 4.7 1.1e-10 41.3 2.0 2.2 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.1 ESA13342.1 - 2e-07 31.0 4.7 0.00012 22.0 0.1 3.2 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_10 PF14788.1 ESA13342.1 - 0.00013 21.5 7.9 0.00024 20.7 0.0 3.4 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 ESA13342.1 - 0.0026 17.5 5.4 1.1 9.2 0.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 ESA13342.1 - 0.02 14.1 3.7 0.61 9.5 0.1 4.0 4 0 0 4 4 4 0 EF hand SPARC_Ca_bdg PF10591.4 ESA13342.1 - 0.16 12.0 5.0 0.087 12.8 0.9 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pox_A3L PF05288.6 ESA13343.1 - 0.025 14.2 1.7 0.063 13.0 0.1 2.6 3 0 0 3 3 3 0 Poxvirus A3L Protein DUF2148 PF09918.4 ESA13345.1 - 0.11 12.1 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) MRP-S25 PF13741.1 ESA13346.1 - 3.5 7.0 5.9 5.7 6.3 1.1 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal protein S25 Kelch_3 PF13415.1 ESA13347.1 - 2.1e-11 43.6 15.8 0.0046 17.0 0.0 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA13347.1 - 4.8e-11 42.3 15.1 0.0031 17.6 0.0 6.8 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.1 ESA13347.1 - 1.8e-10 40.5 19.6 9.3e-05 22.2 0.1 6.3 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.1 ESA13347.1 - 6.9e-10 38.5 23.9 0.0045 16.7 0.0 6.7 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA13347.1 - 3.2e-09 36.1 13.6 0.003 17.0 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA13347.1 - 7.1e-08 31.9 11.7 0.017 14.8 0.0 5.4 7 0 0 7 7 7 3 Kelch motif PP_M1 PF03012.9 ESA13348.1 - 0.027 13.8 0.3 0.041 13.2 0.2 1.3 1 0 0 1 1 1 0 Phosphoprotein Ion_trans PF00520.26 ESA13350.1 - 1.9e-15 56.6 18.2 1.9e-15 56.6 12.6 1.9 1 1 1 2 2 2 1 Ion transport protein BTB PF00651.26 ESA13351.1 - 2.3e-15 56.5 0.1 5.3e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA13351.1 - 5.2e-12 45.9 0.4 1.3e-11 44.6 0.3 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA13351.1 - 0.0055 16.5 5.4 0.0061 16.3 1.0 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF285 PF03382.9 ESA13351.1 - 0.03 13.8 1.5 0.05 13.1 0.0 2.0 2 0 0 2 2 2 0 Mycoplasma protein of unknown function, DUF285 BTB PF00651.26 ESA13353.1 - 3.3e-18 65.7 0.2 5.5e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13353.1 - 4.4e-10 39.3 1.8 2.4e-06 27.3 0.1 4.0 4 1 1 5 5 5 2 BTB And C-terminal Kelch TLD PF07534.11 ESA13353.1 - 1.1e-08 35.1 1.3 9.9e-08 32.0 0.4 2.3 2 0 0 2 2 2 1 TLD Pox_E2-like PF04497.7 ESA13354.1 - 0.059 11.4 0.0 0.059 11.4 0.0 1.0 1 0 0 1 1 1 0 Poxviridae protein PsbN PF02468.10 ESA13354.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Pkinase_Tyr PF07714.12 ESA13356.1 - 1.1e-29 103.3 0.0 1.4e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13356.1 - 1.2e-27 96.7 0.3 5e-27 94.6 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Orbi_VP6 PF01516.11 ESA13357.1 - 0.0069 15.4 0.4 0.0087 15.1 0.3 1.1 1 0 0 1 1 1 1 Orbivirus helicase VP6 DUF1044 PF06296.7 ESA13357.1 - 0.035 13.9 0.5 0.049 13.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1044) Ion_trans PF00520.26 ESA13359.1 - 3.6e-05 23.1 9.4 3.6e-05 23.1 6.5 2.2 1 1 1 2 2 2 1 Ion transport protein PKD_channel PF08016.7 ESA13359.1 - 0.0019 16.7 10.7 0.0031 16.0 7.4 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 ESA13362.1 - 9.4e-07 28.2 13.7 9.4e-07 28.2 9.5 2.2 1 1 2 3 3 3 1 Ion transport protein PKD_channel PF08016.7 ESA13362.1 - 0.011 14.1 13.9 0.047 12.1 6.4 2.4 2 1 0 2 2 2 0 Polycystin cation channel SDA1 PF05285.7 ESA13363.1 - 0.047 12.9 12.7 0.064 12.5 8.8 1.1 1 0 0 1 1 1 0 SDA1 RXT2_N PF08595.6 ESA13363.1 - 0.15 11.8 3.8 0.29 10.9 2.6 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Nucleoplasmin PF03066.10 ESA13363.1 - 0.17 11.3 2.8 0.29 10.6 2.0 1.4 1 0 0 1 1 1 0 Nucleoplasmin Usp PF00582.21 ESA13364.1 - 1e-07 32.2 0.0 6.5e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 Universal stress protein family Med22 PF06179.7 ESA13364.1 - 0.00036 20.5 0.1 0.00095 19.1 0.1 1.7 1 1 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex PIG-L PF02585.12 ESA13364.1 - 0.0017 18.8 0.2 0.035 14.6 0.0 2.3 1 1 1 2 2 2 1 GlcNAc-PI de-N-acetylase Rota_NS53 PF00981.12 ESA13364.1 - 0.65 8.5 8.9 2.2 6.8 6.2 1.6 1 1 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) F-box-like PF12937.2 ESA13365.1 - 1.2e-05 24.8 0.8 7.4e-05 22.4 0.0 2.4 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.1 ESA13365.1 - 0.0026 17.6 26.9 0.07 13.2 1.2 6.8 8 0 0 8 8 8 2 Leucine Rich repeat LRR_4 PF12799.2 ESA13365.1 - 0.048 13.3 1.0 0.048 13.3 0.7 5.7 5 2 0 5 5 5 0 Leucine Rich repeats (2 copies) DUF1284 PF06935.6 ESA13365.1 - 0.11 12.6 7.9 2.1 8.5 0.8 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1284) LRR_7 PF13504.1 ESA13365.1 - 1.6 9.2 15.1 30 5.4 0.1 6.6 6 0 0 6 6 6 0 Leucine rich repeat Fib_alpha PF08702.5 ESA13367.1 - 0.13 12.3 0.8 0.16 12.1 0.6 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Rad60-SLD PF11976.3 ESA13368.1 - 3.9e-12 45.6 0.0 4.9e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESA13368.1 - 0.0036 16.6 0.0 0.0043 16.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA13369.1 - 5e-15 54.9 1.4 7e-15 54.4 1.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 ESA13369.1 - 2e-06 27.1 1.0 2.8e-06 26.6 0.7 1.2 1 0 0 1 1 1 1 Ubiquitin family DUF3671 PF12420.3 ESA13370.1 - 0.034 14.1 2.2 0.047 13.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function MRVI1 PF05781.7 ESA13370.1 - 0.16 10.3 0.8 0.19 10.0 0.5 1.1 1 0 0 1 1 1 0 MRVI1 protein DUF3955 PF13127.1 ESA13370.1 - 0.43 10.1 3.7 0.27 10.7 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3955) Bromodomain PF00439.20 ESA13371.1 - 3.4e-13 49.3 0.4 3.5e-13 49.2 0.3 1.0 1 0 0 1 1 1 1 Bromodomain Tweety PF04906.8 ESA13373.1 - 0.13 10.6 0.6 0.14 10.5 0.4 1.1 1 0 0 1 1 1 0 Tweety DUF902 PF06001.8 ESA13373.1 - 0.21 11.7 0.2 0.21 11.7 0.1 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) eIF-3c_N PF05470.7 ESA13374.1 - 0.013 13.5 0.1 0.017 13.2 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus zf-C2H2_4 PF13894.1 ESA13375.1 - 0.014 15.6 1.1 0.062 13.6 0.2 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA13375.1 - 0.058 13.7 0.6 0.058 13.7 0.4 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3544 PF12064.3 ESA13375.1 - 0.077 12.7 0.3 0.1 12.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3544) DUF3614 PF12267.3 ESA13376.1 - 1.5 9.0 8.5 1.5 9.0 3.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3614) F-box-like PF12937.2 ESA13379.1 - 0.00036 20.1 4.5 0.00046 19.8 1.6 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA13379.1 - 0.77 9.4 4.1 8 6.2 1.0 3.6 2 1 0 2 2 2 0 F-box domain Fer4_2 PF12797.2 ESA13380.1 - 1.3 9.0 4.0 1.5 8.9 0.7 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4 PF00037.22 ESA13380.1 - 1.4 8.6 6.0 0.22 11.1 0.7 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain DUF2805 PF10985.3 ESA13381.1 - 0.03 14.2 0.1 0.03 14.2 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2805) Protocadherin PF08374.6 ESA13381.1 - 1.2 8.7 7.5 1.7 8.2 5.2 1.2 1 0 0 1 1 1 0 Protocadherin Pkinase_Tyr PF07714.12 ESA13382.1 - 7.2e-16 58.0 0.0 1e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13382.1 - 1.9e-14 53.4 0.0 3e-14 52.8 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain BTB PF00651.26 ESA13383.1 - 0.002 18.0 0.0 0.0032 17.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA13384.1 - 4.9e-18 65.1 0.0 7.3e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13384.1 - 0.00059 19.6 0.4 0.018 14.8 0.0 3.1 3 1 1 4 4 4 1 BTB And C-terminal Kelch Clathrin PF00637.15 ESA13384.1 - 0.84 9.2 7.3 0.62 9.6 0.7 3.0 2 1 2 4 4 4 0 Region in Clathrin and VPS FAD_binding_4 PF01565.18 ESA13385.1 - 6.2e-26 90.5 0.1 1.1e-25 89.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 ESA13385.1 - 9e-11 41.5 1.0 1.8e-10 40.5 0.7 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.5 ESA13385.1 - 0.041 13.0 0.4 0.19 10.8 0.1 2.1 2 1 0 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Myb_DNA-binding PF00249.26 ESA13389.1 - 0.0045 17.0 0.0 0.0088 16.0 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Mis14 PF08641.7 ESA13389.1 - 0.036 14.1 0.0 0.047 13.7 0.0 1.3 1 1 0 1 1 1 0 Kinetochore protein Mis14 like Myb_DNA-bind_6 PF13921.1 ESA13389.1 - 0.1 12.7 0.2 0.19 11.8 0.1 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA13390.1 - 0.0037 17.2 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Mis14 PF08641.7 ESA13390.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.4 1 1 0 1 1 1 0 Kinetochore protein Mis14 like Myb_DNA-bind_6 PF13921.1 ESA13390.1 - 0.13 12.3 0.3 0.39 10.8 0.1 1.8 1 1 1 2 2 2 0 Myb-like DNA-binding domain 7tm_1 PF00001.16 ESA13391.1 - 0.005 16.0 0.0 0.0051 15.9 0.0 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) BTB PF00651.26 ESA13394.1 - 4.4e-16 58.8 0.0 4.9e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain MU117 PF15474.1 ESA13395.1 - 0.25 11.8 1.7 1 9.8 1.2 1.9 1 1 0 1 1 1 0 Meiotically up-regulated gene family DUF2283 PF10049.4 ESA13397.1 - 2.8e-06 27.0 0.7 2.8e-06 27.0 0.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2283) Apt1 PF10351.4 ESA13400.1 - 1.9e-117 392.9 20.7 1.9e-117 392.9 14.3 2.1 2 0 0 2 2 2 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.4 ESA13400.1 - 2.4e-42 144.9 0.9 2.4e-42 144.9 0.6 3.7 4 0 0 4 4 4 2 RNA pol II promoter Fmp27 protein domain DUF4146 PF13652.1 ESA13401.1 - 0.015 15.0 0.9 0.038 13.8 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4146) PUA PF01472.15 ESA13402.1 - 9.1e-18 63.7 0.1 1.4e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 PUA domain CaMBD PF02888.11 ESA13406.1 - 0.049 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Calmodulin binding domain DUF4485 PF14846.1 ESA13406.1 - 0.05 13.3 0.2 0.13 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) F-box-like PF12937.2 ESA13407.1 - 3.8e-10 39.3 0.5 1e-09 37.9 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13407.1 - 1.9e-05 24.1 0.3 8.1e-05 22.1 0.2 2.2 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.2 ESA13407.1 - 2.5e-05 23.7 19.6 0.14 11.7 0.1 6.3 2 1 4 6 6 6 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA13407.1 - 3.5e-05 23.4 27.8 1.4 9.2 0.2 9.0 10 0 0 10 10 10 4 Leucine Rich repeat LRR_8 PF13855.1 ESA13407.1 - 0.001 18.7 23.1 0.38 10.5 0.6 6.2 3 3 3 6 6 6 4 Leucine rich repeat LRR_7 PF13504.1 ESA13407.1 - 0.24 11.7 18.3 35 5.2 0.1 8.3 8 1 0 8 8 8 0 Leucine rich repeat DUF1399 PF07173.7 ESA13409.1 - 9.7e-09 35.6 0.3 1.9e-08 34.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1399) zf-RING_4 PF14570.1 ESA13409.1 - 0.018 14.6 5.2 0.18 11.3 2.2 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Terminase_GpA PF05876.7 ESA13409.1 - 0.065 11.5 0.2 0.085 11.1 0.1 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) DZR PF12773.2 ESA13409.1 - 0.069 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 ESA13409.1 - 0.22 11.2 4.0 4.6 6.9 2.9 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C4_Topoisom PF01396.14 ESA13409.1 - 0.31 10.5 3.6 5.5 6.5 0.3 2.3 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger HobA PF12163.3 ESA13411.1 - 0.00099 18.4 0.2 0.0014 17.9 0.2 1.2 1 0 0 1 1 1 1 DNA replication regulator Ion_trans PF00520.26 ESA13412.1 - 6.6e-05 22.2 1.0 8.1e-05 21.9 0.7 1.2 1 0 0 1 1 1 1 Ion transport protein TRP PF06011.7 ESA13412.1 - 0.2 10.1 1.1 0.25 9.8 0.8 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel BTB PF00651.26 ESA13414.1 - 5.3e-18 65.0 0.0 7.4e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13414.1 - 0.031 14.0 1.2 1.6 8.6 0.0 2.6 3 0 0 3 3 3 0 BTB And C-terminal Kelch OTT_1508_deam PF14441.1 ESA13415.1 - 0.00044 20.0 0.7 0.00044 20.0 0.5 1.8 2 1 0 2 2 2 1 OTT_1508-like deaminase Tat PF00539.13 ESA13415.1 - 0.2 11.2 6.4 0.56 9.8 0.2 2.4 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) Pkinase_Tyr PF07714.12 ESA13416.1 - 0.00024 20.2 0.8 0.00059 18.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase CCDC155 PF14662.1 ESA13416.1 - 0.39 10.2 37.2 0.26 10.8 16.2 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 TPR_MLP1_2 PF07926.7 ESA13416.1 - 2.4 7.9 45.1 0.23 11.1 10.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1515 PF07439.6 ESA13416.1 - 6.1 6.6 5.3 6.7 6.5 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Toxin_61 PF15538.1 ESA13417.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Putative toxin 61 Herpes_V23 PF01802.12 ESA13418.1 - 0.0054 15.8 0.1 0.0057 15.7 0.0 1.0 1 0 0 1 1 1 1 Herpesvirus VP23 like capsid protein RE_HindIII PF09518.5 ESA13420.1 - 0.025 13.5 0.4 0.027 13.4 0.3 1.1 1 0 0 1 1 1 0 HindIII restriction endonuclease DUF787 PF05619.6 ESA13420.1 - 0.14 10.7 0.2 0.18 10.4 0.2 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) DUF2805 PF10985.3 ESA13421.1 - 0.022 14.7 0.3 0.028 14.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) MRP-S33 PF08293.6 ESA13421.1 - 0.074 13.0 0.5 0.11 12.5 0.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 OTT_1508_deam PF14441.1 ESA13423.1 - 3.3e-12 46.4 0.9 6.8e-12 45.3 0.6 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase DYW_deaminase PF14432.1 ESA13423.1 - 0.0068 16.3 2.1 0.0068 16.3 1.5 1.9 2 0 0 2 2 2 1 DYW family of nucleic acid deaminases DUF1546 PF07571.8 ESA13423.1 - 0.038 14.1 0.1 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1546) DUF1638 PF07796.6 ESA13423.1 - 0.044 13.4 0.4 0.12 12.0 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) Chitin_synth_2 PF03142.10 ESA13424.1 - 1.9e-259 861.4 0.2 3e-259 860.8 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.1 ESA13424.1 - 1.6e-16 60.8 0.0 3.6e-15 56.3 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESA13424.1 - 2.6e-16 59.9 6.0 2.6e-16 59.9 4.2 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.23 ESA13424.1 - 1.3e-06 28.1 0.1 3.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 ESA13424.1 - 0.0068 15.7 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 zinc-ribbons_6 PF07191.7 ESA13426.1 - 0.0003 20.5 0.7 0.00034 20.3 0.5 1.1 1 0 0 1 1 1 1 zinc-ribbons C1_1 PF00130.17 ESA13426.1 - 0.032 13.9 3.6 0.38 10.5 2.8 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2616 PF11077.3 ESA13426.1 - 0.042 13.3 1.3 0.04 13.3 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) zf-C4_ClpX PF06689.8 ESA13426.1 - 0.048 13.1 4.8 1.1 8.8 0.4 2.2 2 0 0 2 2 2 0 ClpX C4-type zinc finger DZR PF12773.2 ESA13426.1 - 0.059 13.1 1.3 0.078 12.8 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon NMD3 PF04981.8 ESA13426.1 - 0.061 12.4 0.6 0.064 12.3 0.4 1.1 1 0 0 1 1 1 0 NMD3 family DUF2256 PF10013.4 ESA13426.1 - 0.18 11.5 4.0 0.38 10.5 2.9 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2 PF00096.21 ESA13426.1 - 0.35 11.3 2.2 0.63 10.4 0.3 2.1 1 1 1 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.22 ESA13428.1 - 9.4e-06 25.1 0.3 9.4e-06 25.1 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DS PF01916.12 ESA13428.1 - 0.028 13.5 0.5 0.032 13.3 0.3 1.1 1 0 0 1 1 1 0 Deoxyhypusine synthase Cyc-maltodext_N PF09087.6 ESA13428.1 - 0.13 12.2 0.8 0.13 12.2 0.6 1.1 1 0 0 1 1 1 0 Cyclomaltodextrinase, N-terminal TLD PF07534.11 ESA13429.1 - 9.8e-09 35.3 3.3 1.3e-08 34.9 1.2 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA13429.1 - 0.00015 21.5 0.4 0.0039 17.0 0.0 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA13430.1 - 5.6e-16 58.5 1.5 8.6e-16 57.9 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA13430.1 - 1.8e-09 37.3 2.3 7.4e-09 35.3 0.0 3.0 3 0 0 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA13430.1 - 4.3e-07 30.0 1.0 3.7e-06 26.9 0.3 2.4 2 0 0 2 2 2 1 TLD DUF3342 PF11822.3 ESA13430.1 - 0.0063 15.6 0.7 0.01 15.0 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) TLD PF07534.11 ESA13431.1 - 2.9e-09 37.0 4.2 5.1e-09 36.2 2.9 1.4 1 1 0 1 1 1 1 TLD DnaI_N PF07319.6 ESA13432.1 - 1.2 9.4 9.6 0.048 13.8 1.4 2.5 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus MULE PF10551.4 ESA13433.1 - 0.0011 19.1 0.3 0.0074 16.4 0.1 2.0 2 0 0 2 2 2 1 MULE transposase domain tRNA-synt_1c PF00749.16 ESA13434.1 - 5.3e-110 366.9 0.1 1.1e-109 365.8 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 ESA13434.1 - 2e-37 128.5 2.9 2e-37 128.5 2.0 2.3 2 1 1 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 ESA13434.1 - 7e-10 39.2 0.5 2.8e-09 37.3 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESA13434.1 - 5.5e-07 29.4 0.1 3e-06 27.1 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA13434.1 - 4.7e-05 23.1 0.1 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TLD PF07534.11 ESA13435.1 - 2.1e-26 92.5 0.6 3.4e-26 91.8 0.4 1.4 1 0 0 1 1 1 1 TLD SWIM PF04434.12 ESA13437.1 - 0.0036 16.7 0.3 0.0069 15.8 0.2 1.4 1 0 0 1 1 1 1 SWIM zinc finger Cys_rich_VLP PF14194.1 ESA13437.1 - 0.011 15.4 0.1 0.025 14.3 0.1 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP SWIM PF04434.12 ESA13438.1 - 0.0033 16.8 0.4 0.0061 15.9 0.3 1.4 1 0 0 1 1 1 1 SWIM zinc finger Cys_rich_VLP PF14194.1 ESA13438.1 - 0.0099 15.5 0.3 0.026 14.2 0.2 1.6 1 0 0 1 1 1 1 Cysteine-rich VLP Pkinase_Tyr PF07714.12 ESA13439.1 - 4e-11 42.4 0.0 7.6e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13439.1 - 1.7e-10 40.5 1.6 3.1e-10 39.6 0.3 2.0 2 1 0 2 2 2 1 Protein kinase domain NOB1_Zn_bind PF08772.6 ESA13439.1 - 0.0052 16.5 9.1 0.15 11.9 1.2 2.7 2 0 0 2 2 2 2 Nin one binding (NOB1) Zn-ribbon like DUF2004 PF09406.5 ESA13439.1 - 0.016 15.2 0.9 0.1 12.6 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2004) DUF3027 PF11228.3 ESA13439.1 - 0.068 12.8 0.0 3.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) DUF4413 PF14372.1 ESA13439.1 - 0.12 12.4 4.7 0.97 9.4 0.6 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) Chal_sti_synt_N PF00195.14 ESA13439.1 - 0.26 10.4 3.3 0.26 10.5 0.7 1.9 2 0 0 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain DUF3740 PF12548.3 ESA13439.1 - 3 8.1 11.1 0.1 12.8 0.8 2.8 3 0 0 3 3 3 0 Sulfatase protein HMG_box_2 PF09011.5 ESA13440.1 - 0.016 15.5 0.1 0.027 14.8 0.1 1.3 1 0 0 1 1 1 0 HMG-box domain Cys_Met_Meta_PP PF01053.15 ESA13441.1 - 1.8e-07 29.7 0.0 1.9e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Mo-co_dimer PF03404.11 ESA13445.1 - 9.6e-49 164.3 0.1 2e-48 163.3 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.14 ESA13445.1 - 5.1e-37 126.8 0.0 9.6e-37 125.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Cyt-b5 PF00173.23 ESA13445.1 - 4.9e-26 90.3 0.7 1.2e-25 89.0 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF1344 PF07076.6 ESA13445.1 - 0.069 12.7 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) Pkinase PF00069.20 ESA13446.1 - 6.7e-31 107.3 0.5 7e-31 107.3 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13446.1 - 1.6e-27 96.1 0.0 1.8e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA13446.1 - 0.012 15.3 0.4 0.026 14.2 0.1 1.5 1 1 0 2 2 2 0 Phosphotransferase enzyme family Imm47 PF15586.1 ESA13446.1 - 0.084 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 47 Kinase-like PF14531.1 ESA13446.1 - 0.16 10.9 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Asp_protease_2 PF13650.1 ESA13447.1 - 0.028 14.9 0.0 0.056 13.9 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.15 ESA13447.1 - 0.043 13.7 0.0 2 8.3 0.0 2.3 1 1 0 1 1 1 0 Retroviral aspartyl protease RVP PF00077.15 ESA13448.1 - 0.0045 16.8 0.1 0.21 11.5 0.1 2.3 1 1 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 ESA13448.1 - 0.014 15.9 0.0 0.023 15.1 0.0 1.5 1 1 0 1 1 1 0 Aspartyl protease Ceramidase_alk PF04734.8 ESA13449.1 - 0.18 9.6 0.1 0.25 9.1 0.1 1.1 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase DUF4408 PF14364.1 ESA13450.1 - 0.00013 21.4 0.4 0.00021 20.7 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4408) Pkinase_Tyr PF07714.12 ESA13451.1 - 3e-44 151.0 0.0 8.2e-43 146.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13451.1 - 7.9e-41 139.9 0.1 2.8e-40 138.1 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Laminin_EGF PF00053.19 ESA13451.1 - 0.1 12.5 1.3 0.2 11.6 0.9 1.4 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) SAM_1 PF00536.25 ESA13453.1 - 0.0062 16.6 0.1 0.019 15.1 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF2972 PF11186.3 ESA13453.1 - 0.3 10.9 3.1 0.11 12.4 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) F-box-like PF12937.2 ESA13454.1 - 5e-10 38.9 0.3 9.7e-10 38.0 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13454.1 - 3.7e-08 32.8 0.2 8.9e-08 31.6 0.1 1.6 1 0 0 1 1 1 1 F-box domain RRM_1 PF00076.17 ESA13455.1 - 3.1e-06 26.7 0.0 5.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA13455.1 - 0.064 13.2 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Spermine_synth PF01564.12 ESA13457.1 - 4.7e-09 35.5 0.0 8.2e-09 34.7 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_30 PF05430.6 ESA13457.1 - 0.02 14.5 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_PK PF05891.7 ESA13457.1 - 0.053 12.8 0.0 0.091 12.0 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.1 ESA13457.1 - 0.13 12.0 0.1 0.28 10.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Uteroglobin PF01099.12 ESA13457.1 - 0.16 11.7 0.0 0.51 10.1 0.0 1.8 1 0 0 1 1 1 0 Uteroglobin family Ras PF00071.17 ESA13458.1 - 8.1e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 ESA13458.1 - 0.00015 21.7 0.1 0.00017 21.5 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA13458.1 - 0.00026 21.2 0.0 0.00029 21.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AIG1 PF04548.11 ESA13458.1 - 0.00031 19.9 0.0 0.00031 19.9 0.0 1.2 1 0 0 1 1 1 1 AIG1 family AAA_17 PF13207.1 ESA13458.1 - 0.0028 18.4 0.0 0.0033 18.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA13458.1 - 0.0033 17.1 0.2 0.004 16.8 0.1 1.2 1 0 0 1 1 1 1 Archaeal ATPase T2SE PF00437.15 ESA13458.1 - 0.0071 15.2 0.0 0.0071 15.2 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein Septin PF00735.13 ESA13458.1 - 0.0075 15.3 0.1 0.01 14.8 0.0 1.3 1 1 0 1 1 1 1 Septin FtsK_SpoIIIE PF01580.13 ESA13458.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_21 PF13304.1 ESA13458.1 - 0.015 15.3 0.1 0.018 14.9 0.1 1.3 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESA13458.1 - 0.017 15.3 0.1 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 ESA13458.1 - 0.019 14.7 0.2 0.033 14.0 0.1 1.6 1 1 0 1 1 1 0 Dynamin family Miro PF08477.8 ESA13458.1 - 0.027 14.9 0.0 0.031 14.7 0.0 1.2 1 0 0 1 1 1 0 Miro-like protein AAA_14 PF13173.1 ESA13458.1 - 0.028 14.3 0.0 0.032 14.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESA13458.1 - 0.03 13.7 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 ESA13458.1 - 0.032 13.7 0.0 0.064 12.7 0.0 1.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF4568 PF15132.1 ESA13458.1 - 0.062 12.4 0.0 0.07 12.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) CobU PF02283.11 ESA13458.1 - 0.087 12.2 0.1 0.29 10.5 0.0 1.7 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_23 PF13476.1 ESA13458.1 - 0.33 11.2 4.9 1.5 9.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain Fasciclin PF02469.17 ESA13459.1 - 3e-39 133.9 1.2 6.9e-19 68.1 0.1 2.3 2 0 0 2 2 2 2 Fasciclin domain HMG_box PF00505.14 ESA13460.1 - 4.5e-08 33.2 0.5 7.9e-08 32.4 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box Auxin_repressed PF05564.7 ESA13460.1 - 0.48 11.0 3.6 0.45 11.1 0.1 2.1 2 0 0 2 2 2 0 Dormancy/auxin associated protein EFP_N PF08207.7 ESA13461.1 - 0.034 14.0 0.4 0.048 13.5 0.3 1.4 1 1 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain DUF1108 PF06531.6 ESA13461.1 - 0.11 12.6 0.5 0.17 12.0 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1108) Spore_GerQ PF09671.5 ESA13461.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Spore coat protein (Spore_GerQ) AAA_18 PF13238.1 ESA13462.1 - 5e-08 33.3 2.3 7e-07 29.6 1.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA13462.1 - 2.9e-06 28.0 0.2 0.0001 23.1 0.2 2.1 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 ESA13462.1 - 0.0036 16.8 0.3 0.015 14.9 0.2 1.8 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_sub_bind PF04392.7 ESA13462.1 - 0.014 14.3 0.7 0.075 11.9 0.3 1.9 1 1 1 2 2 2 0 ABC transporter substrate binding protein tRNA_lig_kinase PF08303.6 ESA13462.1 - 0.016 15.0 0.7 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain Carbpep_Y_N PF05388.6 ESA13462.1 - 0.071 13.2 0.3 0.22 11.7 0.2 1.8 1 1 0 1 1 1 0 Carboxypeptidase Y pro-peptide AAA_33 PF13671.1 ESA13462.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain Ion_trans PF00520.26 ESA13463.1 - 0.00021 20.5 15.2 0.00044 19.5 10.5 1.6 1 0 0 1 1 1 1 Ion transport protein BACK PF07707.10 ESA13463.1 - 0.3 10.9 3.9 0.2 11.5 0.2 2.4 3 0 0 3 3 3 0 BTB And C-terminal Kelch Ufd2P_core PF10408.4 ESA13464.1 - 8.2e-194 645.3 21.6 9.3e-194 645.2 15.0 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 ESA13464.1 - 6.9e-26 90.0 2.3 1.3e-25 89.1 0.9 2.1 2 0 0 2 2 2 1 U-box domain zf-C4H2 PF10146.4 ESA13464.1 - 0.012 15.6 1.8 0.012 15.6 1.3 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein DNA_topoisoIV PF00521.15 ESA13464.1 - 2.1 7.0 9.9 1.4 7.6 5.2 1.9 2 1 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A Asp23 PF03780.8 ESA13467.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Asp23 family BTB PF00651.26 ESA13469.1 - 5.7e-18 64.9 0.0 1.3e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13469.1 - 2.9e-07 30.2 6.1 9.3e-06 25.4 0.7 3.2 1 1 2 3 3 3 2 BTB And C-terminal Kelch RPAP3_C PF13877.1 ESA13469.1 - 0.084 12.8 0.5 2.5 8.1 0.1 2.9 1 1 2 3 3 3 0 Potential Monad-binding region of RPAP3 TLD PF07534.11 ESA13470.1 - 1.2e-08 35.0 0.2 1.2e-08 35.0 0.1 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA13470.1 - 1.3 8.8 4.0 2.1 8.2 0.1 2.7 2 1 1 3 3 3 0 BTB And C-terminal Kelch SPRY PF00622.23 ESA13472.1 - 5.3e-26 91.1 0.3 8e-26 90.5 0.2 1.3 1 0 0 1 1 1 1 SPRY domain DUF4451 PF14616.1 ESA13473.1 - 3.2e-23 81.8 0.2 3.6e-23 81.6 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) DUF912 PF06024.7 ESA13477.1 - 0.027 14.5 0.5 0.056 13.5 0.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MMS1_N PF10433.4 ESA13482.1 - 2e-74 250.5 0.2 2.9e-74 250.0 0.1 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.10 ESA13482.1 - 2.1e-73 247.2 0.0 5.7e-73 245.8 0.0 1.8 2 0 0 2 2 2 1 CPSF A subunit region SIR2 PF02146.12 ESA13483.1 - 7.2e-20 71.4 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Sir2 family BIR PF00653.16 ESA13483.1 - 0.04 14.3 0.2 0.067 13.6 0.2 1.3 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain DUF4218 PF13960.1 ESA13484.1 - 6e-08 32.1 1.1 1.6e-07 30.7 0.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Transposase_21 PF02992.9 ESA13484.1 - 0.00011 21.3 0.4 0.0003 19.9 0.1 1.9 2 0 0 2 2 2 1 Transposase family tnp2 DPBB_1 PF03330.13 ESA13487.1 - 1.5e-06 28.1 0.0 1.9e-06 27.8 0.0 1.3 1 1 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 ESA13487.1 - 0.00011 21.8 0.2 0.00016 21.3 0.1 1.3 1 1 0 1 1 1 1 Barwin family Aminotran_5 PF00266.14 ESA13488.1 - 2e-35 122.2 0.0 2.9e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 ESA13488.1 - 0.00012 21.1 0.0 0.00019 20.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Sel1 PF08238.7 ESA13490.1 - 1.7e-156 505.2 76.4 1.4e-11 44.6 0.1 18.1 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA13490.1 - 1.1e-09 38.0 29.3 1 9.9 0.0 13.3 13 1 0 13 13 13 4 Tetratricopeptide repeat Retinin_C PF04527.7 ESA13492.1 - 0.027 14.4 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 Drosophila Retinin like protein AAA_22 PF13401.1 ESA13494.1 - 0.022 14.9 0.1 0.48 10.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 ESA13494.1 - 0.028 13.5 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 KaiC RNA_helicase PF00910.17 ESA13494.1 - 0.03 14.4 0.3 0.38 10.9 0.0 2.6 2 1 0 2 2 2 0 RNA helicase AAA_10 PF12846.2 ESA13494.1 - 0.037 13.4 0.0 0.14 11.5 0.0 2.0 1 1 1 2 2 2 0 AAA-like domain MitMem_reg PF13012.1 ESA13494.1 - 0.053 13.6 0.0 0.22 11.6 0.0 2.0 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function AAA_17 PF13207.1 ESA13494.1 - 0.054 14.3 0.1 2.3 9.0 0.0 3.0 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA13494.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF659 PF04937.10 ESA13497.1 - 0.047 13.1 0.6 0.066 12.7 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF 659) Sel1 PF08238.7 ESA13498.1 - 2e-91 298.4 45.6 1.6e-11 44.4 0.3 10.0 10 0 0 10 10 10 9 Sel1 repeat MIT PF04212.13 ESA13498.1 - 5.5e-10 38.9 28.3 0.23 11.3 0.1 8.4 8 0 0 8 8 8 6 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA13498.1 - 4.6e-06 26.2 9.9 1.7 8.4 0.0 7.4 8 0 0 8 8 8 1 Lung surfactant protein D coiled-coil trimerisation TPR_6 PF13174.1 ESA13498.1 - 0.0026 18.0 19.3 2 9.0 0.1 7.9 8 0 0 8 8 8 1 Tetratricopeptide repeat zinc-ribbons_6 PF07191.7 ESA13498.1 - 0.0066 16.2 0.8 0.015 15.0 0.5 1.5 1 0 0 1 1 1 1 zinc-ribbons DUF3574 PF12098.3 ESA13498.1 - 0.086 12.4 0.7 51 3.5 0.0 3.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3574) TPR_17 PF13431.1 ESA13498.1 - 0.093 12.9 10.3 5 7.5 0.2 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF3674 PF12426.3 ESA13498.1 - 0.2 11.1 11.9 1.2 8.5 0.5 3.9 4 0 0 4 4 4 0 RNA dependent RNA polymerase Glu_syn_central PF04898.9 ESA13498.1 - 0.87 8.7 7.5 40 3.3 0.0 5.1 3 1 3 6 6 6 0 Glutamate synthase central domain Prenyltrans_1 PF13243.1 ESA13498.1 - 5.1 7.1 10.2 28 4.7 0.7 4.6 2 1 1 3 3 3 0 Prenyltransferase-like Spot_14 PF07084.7 ESA13498.1 - 8.4 6.2 6.5 12 5.7 0.4 3.7 3 2 2 5 5 5 0 Thyroid hormone-inducible hepatic protein Spot 14 Sel1 PF08238.7 ESA13499.1 - 4.4e-70 230.5 48.7 3e-11 43.5 0.7 8.5 9 0 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.1 ESA13499.1 - 1.1e-07 31.8 26.4 0.13 12.7 0.7 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA13499.1 - 0.00072 19.2 8.4 31 4.4 0.0 6.1 7 0 0 7 7 7 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA13499.1 - 0.0074 16.3 19.9 5.7 7.3 0.4 7.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA13499.1 - 0.027 15.1 11.0 6.5 7.5 0.1 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA13499.1 - 0.04 13.8 28.1 3.3 7.6 0.4 7.0 6 2 1 8 8 8 0 MIT (microtubule interacting and transport) domain HTH_16 PF12645.2 ESA13499.1 - 0.078 12.9 5.4 3.1 7.8 0.1 4.1 4 0 0 4 4 4 0 Helix-turn-helix domain DUF1642 PF07852.6 ESA13499.1 - 2.4 8.5 13.1 20 5.5 5.2 3.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1642) Foie-gras_1 PF11817.3 ESA13499.1 - 2.7 7.3 9.8 6.1e+02 -0.4 6.8 3.3 1 1 0 1 1 1 0 Foie gras liver health family 1 Sel1 PF08238.7 ESA13500.1 - 6.5e-116 376.2 58.3 7.7e-13 48.6 0.7 11.0 11 0 0 11 11 11 11 Sel1 repeat TPR_17 PF13431.1 ESA13500.1 - 3.5e-12 45.5 32.0 0.45 10.8 0.1 11.6 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_6 PF13174.1 ESA13500.1 - 9.4e-12 44.5 29.0 0.088 13.3 0.0 9.4 11 0 0 11 11 11 5 Tetratricopeptide repeat MIT PF04212.13 ESA13500.1 - 1.2e-10 41.1 37.8 0.42 10.5 0.0 10.0 9 1 0 9 9 9 6 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA13500.1 - 1.7e-06 27.5 65.7 0.07 12.7 4.3 9.8 1 1 8 10 10 10 7 TPR repeat Peptidase_C14 PF00656.17 ESA13500.1 - 0.00019 21.2 0.0 7.4 6.1 0.0 4.6 1 1 2 3 3 3 2 Caspase domain Surfac_D-trimer PF09006.6 ESA13500.1 - 0.0002 21.0 15.4 32 4.3 0.0 8.5 10 0 0 10 10 10 0 Lung surfactant protein D coiled-coil trimerisation ICAP-1_inte_bdg PF10480.4 ESA13500.1 - 0.043 13.5 3.8 4.4 7.0 0.0 5.1 4 1 2 7 7 7 0 Beta-1 integrin binding protein DUF3574 PF12098.3 ESA13500.1 - 0.17 11.4 1.3 77 2.9 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3574) DUF3674 PF12426.3 ESA13500.1 - 0.23 10.9 5.0 1.6e+02 1.8 0.0 5.5 6 0 0 6 6 6 0 RNA dependent RNA polymerase HTH_16 PF12645.2 ESA13500.1 - 2.5 8.0 15.8 1.7 8.6 0.0 4.9 7 0 0 7 7 7 0 Helix-turn-helix domain DUF1053 PF06327.9 ESA13501.1 - 0.017 15.4 0.5 1.7 9.0 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) Pkinase PF00069.20 ESA13501.1 - 0.021 13.9 0.1 0.035 13.2 0.0 1.4 2 0 0 2 2 2 0 Protein kinase domain Ribosomal_L1 PF00687.16 ESA13501.1 - 0.18 11.1 1.5 1.4 8.2 0.5 2.0 1 1 1 2 2 2 0 Ribosomal protein L1p/L10e family Pkinase PF00069.20 ESA13504.1 - 5.2e-24 84.8 0.0 7.2e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13504.1 - 2.9e-19 69.1 0.0 3.7e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA13504.1 - 0.044 13.5 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA13505.1 - 0.054 13.2 0.8 0.054 13.2 0.6 2.2 2 0 0 2 2 2 0 F-box-like Sel1 PF08238.7 ESA13506.1 - 8.4e-171 550.7 71.5 1.6e-12 47.6 0.1 17.7 17 1 0 17 17 17 16 Sel1 repeat Pkinase PF00069.20 ESA13506.1 - 1.3e-46 158.8 0.1 2.9e-46 157.7 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13506.1 - 1.5e-45 155.3 0.0 2.3e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_6 PF13174.1 ESA13506.1 - 3e-06 27.3 18.4 8.4 7.0 0.1 10.4 9 1 0 9 9 9 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA13506.1 - 5.9e-06 26.2 0.4 18 5.4 0.0 7.9 4 3 7 11 11 11 1 Influenza Matrix protein (M1) C-terminal domain TPR_16 PF13432.1 ESA13506.1 - 5.1e-05 23.8 3.4 4.9 7.9 0.0 7.4 5 3 5 10 10 10 1 Tetratricopeptide repeat YrbL-PhoP_reg PF10707.4 ESA13506.1 - 0.0062 15.9 0.1 0.019 14.3 0.1 1.8 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA13506.1 - 0.016 14.9 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA13507.1 - 0.00068 19.3 1.0 0.0022 17.6 0.7 1.9 1 0 0 1 1 1 1 F-box-like TLD PF07534.11 ESA13509.1 - 1.3e-12 47.8 1.2 2.4e-12 47.0 0.8 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA13509.1 - 0.00085 19.1 0.1 0.0086 15.9 0.1 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch YtzH PF14165.1 ESA13509.1 - 0.082 13.1 0.9 3.1 8.0 0.2 2.2 2 0 0 2 2 2 0 YtzH-like protein Sel1 PF08238.7 ESA13510.1 - 5.8e-15 55.3 2.4 8.2e-07 29.4 0.2 2.7 3 0 0 3 3 3 2 Sel1 repeat DUF2185 PF09951.4 ESA13510.1 - 0.014 15.1 0.2 1.6 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2185) DUF2209 PF09974.4 ESA13510.1 - 0.081 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DASH_Dad3 PF08656.5 ESA13511.1 - 0.021 14.5 0.6 0.025 14.2 0.4 1.1 1 0 0 1 1 1 0 DASH complex subunit Dad3 DUF1759 PF03564.10 ESA13511.1 - 0.032 14.0 0.3 0.033 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DUF4618 PF15397.1 ESA13511.1 - 0.035 13.4 0.7 0.034 13.4 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) CASP_C PF08172.7 ESA13511.1 - 0.038 13.0 0.5 0.034 13.1 0.4 1.0 1 0 0 1 1 1 0 CASP C terminal SOG2 PF10428.4 ESA13511.1 - 0.055 12.1 0.4 0.054 12.1 0.3 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2413 PF10310.4 ESA13512.1 - 2.4e-70 237.6 10.1 5.2e-70 236.4 7.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2413) MAT1 PF06391.8 ESA13512.1 - 0.041 13.4 1.6 2 7.9 0.5 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 BRO1 PF03097.13 ESA13513.1 - 2.1e-123 411.8 3.2 2.1e-123 411.8 2.2 2.8 3 1 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 ESA13513.1 - 2e-52 178.0 18.0 5.2e-52 176.6 12.5 1.7 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Lipase_GDSL PF00657.17 ESA13517.1 - 3.7e-08 33.4 1.9 4.8e-08 33.1 1.3 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase tRNA_NucTran2_2 PF13735.1 ESA13518.1 - 0.05 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative WD40 PF00400.27 ESA13519.1 - 0.12 12.2 0.0 0.37 10.7 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat Pkinase PF00069.20 ESA13521.1 - 6.4e-05 22.2 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PAM2 PF07145.10 ESA13522.1 - 0.0067 15.8 8.6 0.37 10.4 0.6 2.7 2 0 0 2 2 2 2 Ataxin-2 C-terminal region zf-CCCH PF00642.19 ESA13522.1 - 0.022 14.4 3.4 0.046 13.4 2.4 1.5 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Thymidylate_kin PF02223.12 ESA13523.1 - 2.4e-41 141.1 0.0 2.7e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase DUF1433 PF07252.6 ESA13523.1 - 0.0033 17.5 0.6 0.0053 16.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1433) MRP-S23 PF10484.4 ESA13523.1 - 0.0037 17.1 0.1 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein S23 MobB PF03205.9 ESA13523.1 - 0.022 14.4 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 ESA13523.1 - 0.032 14.3 0.0 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.5 ESA13523.1 - 0.081 12.1 0.2 0.24 10.5 0.0 1.9 2 1 0 2 2 2 0 Chromatin associated protein KTI12 APS_kinase PF01583.15 ESA13523.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase zf-RanBP PF00641.13 ESA13524.1 - 5.4e-33 111.7 45.3 8.5e-08 31.1 2.7 5.5 5 0 0 5 5 5 5 Zn-finger in Ran binding protein and others RNase_T PF00929.19 ESA13524.1 - 2.7e-18 66.7 0.2 4.4e-18 66.1 0.1 1.4 1 0 0 1 1 1 1 Exonuclease RRM_1 PF00076.17 ESA13524.1 - 1.3e-10 40.7 0.0 2.9e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA13524.1 - 4.4e-09 36.1 0.0 2e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 ESA13524.1 - 0.55 10.0 40.0 3.2 7.6 2.4 4.6 1 1 4 5 5 5 0 Double zinc ribbon Auto_anti-p27 PF06677.7 ESA13524.1 - 4.9 6.9 12.6 17 5.2 0.3 4.4 5 0 0 5 5 5 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Pkinase PF00069.20 ESA13525.1 - 1.8e-40 138.7 0.2 2.3e-40 138.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13525.1 - 2.1e-40 138.4 0.0 2.5e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA13525.1 - 4.5e-06 26.0 0.2 8.2e-06 25.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA13525.1 - 0.015 15.0 0.2 0.028 14.1 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_J1 PF03338.10 ESA13525.1 - 0.039 13.6 0.0 0.11 12.1 0.0 1.7 1 1 0 1 1 1 0 Poxvirus J1 protein Pkinase_Tyr PF07714.12 ESA13529.1 - 3.5e-45 154.0 0.1 9.2e-45 152.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13529.1 - 5.1e-39 133.9 1.0 8.3e-39 133.2 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ESA13529.1 - 0.00052 19.0 0.5 0.015 14.3 0.0 2.8 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 ESA13529.1 - 0.032 13.2 0.0 0.066 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PNPase PF03726.9 ESA13529.1 - 10 6.5 8.9 1.3 9.3 1.7 2.9 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Sel1 PF08238.7 ESA13530.1 - 2.2e-43 145.6 11.2 3.2e-09 37.1 0.1 5.6 6 0 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA13530.1 - 0.00018 21.7 3.8 3.7 8.2 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA13530.1 - 0.00054 19.5 6.5 0.54 9.9 0.2 3.8 2 1 2 4 4 4 2 TPR repeat GSH-S_N PF02951.9 ESA13530.1 - 0.019 14.7 0.1 10 5.9 0.0 3.0 3 0 0 3 3 3 0 Prokaryotic glutathione synthetase, N-terminal domain MIT PF04212.13 ESA13530.1 - 3.9 7.4 7.7 11 6.0 0.7 3.8 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain LRR_4 PF12799.2 ESA13532.1 - 0.00033 20.2 0.5 30 4.3 0.2 5.1 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) Methyltransf_11 PF08241.7 ESA13533.1 - 2.7e-14 53.4 0.0 5e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA13533.1 - 2.3e-12 46.9 0.0 3.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13533.1 - 6e-10 38.9 0.0 9.4e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA13533.1 - 3.1e-09 37.1 0.1 5.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA13533.1 - 2e-07 30.3 0.1 3.1e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA13533.1 - 0.00023 21.4 0.0 0.00042 20.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13533.1 - 0.0014 19.1 0.0 0.0042 17.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESA13533.1 - 0.003 16.9 0.0 0.0049 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.7 ESA13533.1 - 0.0073 15.2 0.0 0.013 14.3 0.0 1.5 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_PK PF05891.7 ESA13533.1 - 0.045 13.0 0.1 0.076 12.3 0.1 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase DUF3606 PF12244.3 ESA13533.1 - 0.057 13.0 0.3 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Methyltransf_26 PF13659.1 ESA13533.1 - 0.064 13.2 0.0 0.18 11.8 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain E1_DerP2_DerF2 PF02221.10 ESA13534.1 - 0.00039 20.6 0.0 0.00048 20.3 0.0 1.2 1 0 0 1 1 1 1 ML domain Synaptobrevin PF00957.16 ESA13535.1 - 0.36 10.4 0.0 0.36 10.4 0.0 2.4 3 0 0 3 3 3 0 Synaptobrevin WD40 PF00400.27 ESA13536.1 - 3.8e-26 89.9 5.2 2.5e-11 42.9 0.3 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat CPSF_A PF03178.10 ESA13536.1 - 0.0077 15.3 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region TilS_C PF11734.3 ESA13538.1 - 0.04 13.1 0.6 0.054 12.7 0.4 1.3 1 0 0 1 1 1 0 TilS substrate C-terminal domain Ribosomal_L22 PF00237.14 ESA13539.1 - 6.4e-35 119.2 0.1 8.5e-35 118.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ank_2 PF12796.2 ESA13540.1 - 4.1e-18 65.5 0.1 1.3e-17 63.8 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA13540.1 - 2.8e-13 49.9 0.1 3e-09 37.1 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 ESA13540.1 - 8.7e-13 47.3 0.3 5.1e-08 32.3 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 ESA13540.1 - 1.7e-12 47.1 0.0 5.1e-12 45.6 0.0 1.9 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA13540.1 - 4.7e-10 38.7 0.6 6.8e-06 25.8 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat RrnaAD PF00398.15 ESA13540.1 - 0.043 12.8 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Staphostatin_B PF09023.5 ESA13540.1 - 0.054 13.3 0.0 0.097 12.5 0.0 1.4 1 0 0 1 1 1 0 Staphostatin B NUDIX PF00293.23 ESA13541.1 - 6.1e-12 45.3 0.0 1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Josephin PF02099.12 ESA13542.1 - 7.9e-53 178.2 0.1 1.2e-52 177.6 0.1 1.3 1 0 0 1 1 1 1 Josephin bZIP_1 PF00170.16 ESA13543.1 - 8.5e-07 28.8 18.1 9.4e-06 25.4 12.5 2.3 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 ESA13543.1 - 8.2e-06 25.5 16.3 8.2e-06 25.5 11.3 2.8 2 1 1 3 3 3 2 Basic region leucine zipper bZIP_Maf PF03131.12 ESA13543.1 - 0.00048 20.3 9.4 0.001 19.2 6.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF3450 PF11932.3 ESA13543.1 - 0.0031 16.8 5.0 0.0031 16.8 3.5 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) DUF2968 PF11180.3 ESA13543.1 - 0.0047 16.3 6.2 0.0085 15.4 4.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) TSC22 PF01166.13 ESA13543.1 - 0.0052 16.7 4.3 0.0071 16.2 1.9 2.1 1 1 1 2 2 2 1 TSC-22/dip/bun family TMF_DNA_bd PF12329.3 ESA13543.1 - 0.12 12.1 7.6 0.3 10.9 5.3 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 ESA13543.1 - 0.17 10.8 6.3 0.33 9.8 4.4 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF972 PF06156.8 ESA13543.1 - 0.93 9.8 5.3 2.1 8.7 3.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) PH_9 PF15410.1 ESA13544.1 - 3.2e-06 27.2 0.0 8.6e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESA13544.1 - 1.6e-05 25.0 0.7 0.0004 20.5 0.0 2.9 2 2 0 2 2 2 1 PH domain Fib_alpha PF08702.5 ESA13546.1 - 0.00027 21.0 12.6 0.0028 17.7 5.4 2.1 1 1 0 2 2 2 1 Fibrinogen alpha/beta chain family HOOK PF05622.7 ESA13546.1 - 0.0018 16.2 8.6 0.0018 16.2 5.9 1.9 1 1 1 2 2 2 1 HOOK protein Spc7 PF08317.6 ESA13546.1 - 0.0027 16.4 22.5 0.0044 15.7 9.0 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein MbeD_MobD PF04899.7 ESA13546.1 - 0.003 17.4 4.0 6.7 6.6 0.3 3.3 2 1 1 3 3 3 0 MbeD/MobD like Prefoldin PF02996.12 ESA13546.1 - 0.0035 16.9 4.0 0.0035 16.9 2.7 4.0 2 2 1 4 4 4 1 Prefoldin subunit Tropomyosin PF00261.15 ESA13546.1 - 0.014 14.4 30.2 0.17 10.9 5.0 2.8 1 1 0 2 2 2 0 Tropomyosin AAA_13 PF13166.1 ESA13546.1 - 0.018 13.5 17.5 0.028 12.8 12.1 1.4 1 1 0 1 1 1 0 AAA domain GAS PF13851.1 ESA13546.1 - 0.029 13.5 25.0 0.15 11.2 10.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Med9 PF07544.8 ESA13546.1 - 0.031 14.0 1.3 0.031 14.0 0.9 4.4 2 1 3 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 DUF1906 PF08924.6 ESA13546.1 - 0.032 14.1 0.4 0.064 13.1 0.2 1.6 1 1 1 2 2 1 0 Domain of unknown function (DUF1906) Vps53_N PF04100.7 ESA13546.1 - 0.032 13.0 9.7 0.037 12.8 6.2 1.5 1 1 0 1 1 1 0 Vps53-like, N-terminal Nup54 PF13874.1 ESA13546.1 - 0.044 13.4 12.5 0.039 13.6 3.4 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Spectrin PF00435.16 ESA13546.1 - 0.048 13.9 18.0 0.23 11.7 5.0 3.2 1 1 1 2 2 2 0 Spectrin repeat Reo_sigmaC PF04582.7 ESA13546.1 - 0.057 12.6 4.4 0.24 10.5 1.3 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Filament PF00038.16 ESA13546.1 - 0.058 12.8 21.1 0.61 9.4 14.6 2.2 1 1 0 1 1 1 0 Intermediate filament protein DUF2968 PF11180.3 ESA13546.1 - 0.071 12.4 16.7 0.27 10.5 5.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Prefoldin_2 PF01920.15 ESA13546.1 - 0.11 12.3 29.5 0.14 11.9 4.6 4.3 1 1 3 4 4 4 0 Prefoldin subunit DUF3584 PF12128.3 ESA13546.1 - 0.14 9.4 18.9 0.15 9.3 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Laminin_I PF06008.9 ESA13546.1 - 0.15 11.3 21.1 1.4 8.1 5.2 3.3 1 1 2 3 3 3 0 Laminin Domain I DUF4404 PF14357.1 ESA13546.1 - 0.16 12.4 0.4 0.16 12.4 0.3 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) DUF1110 PF06533.7 ESA13546.1 - 0.16 11.7 4.8 0.47 10.2 0.1 2.4 2 1 1 3 3 2 0 Protein of unknown function (DUF1110) DUF849 PF05853.7 ESA13546.1 - 0.16 10.8 1.2 0.26 10.1 0.7 1.6 1 1 0 1 1 1 0 Prokaryotic protein of unknown function (DUF849) NPV_P10 PF05531.7 ESA13546.1 - 0.17 12.1 10.3 20 5.5 4.1 3.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Corona_S2 PF01601.11 ESA13546.1 - 0.17 9.9 0.8 0.22 9.6 0.6 1.2 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein ATG16 PF08614.6 ESA13546.1 - 0.21 11.3 24.4 0.89 9.3 12.0 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.4 ESA13546.1 - 0.33 10.8 28.6 1.9 8.3 3.6 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.7 ESA13546.1 - 0.35 10.6 5.8 0.26 11.0 1.8 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.7 ESA13546.1 - 0.35 10.5 24.0 1.8 8.2 8.5 3.3 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Arg_repressor PF01316.16 ESA13546.1 - 0.36 10.4 6.3 3.6 7.1 0.5 2.9 3 0 0 3 3 2 0 Arginine repressor, DNA binding domain V_ATPase_I PF01496.14 ESA13546.1 - 0.37 8.5 12.9 0.54 8.0 8.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-C4H2 PF10146.4 ESA13546.1 - 0.4 10.6 19.3 0.24 11.3 12.2 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein TMF_DNA_bd PF12329.3 ESA13546.1 - 0.41 10.4 34.7 6.9 6.5 5.2 3.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF632 PF04782.7 ESA13546.1 - 0.43 9.6 11.8 2.2 7.2 8.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF632) Mnd1 PF03962.10 ESA13546.1 - 0.52 9.9 21.6 1.3 8.6 7.7 2.3 1 1 1 2 2 2 0 Mnd1 family HAMP PF00672.20 ESA13546.1 - 0.52 10.5 2.4 3.5 7.8 0.2 2.4 2 1 0 2 2 2 0 HAMP domain Phage_GP20 PF06810.6 ESA13546.1 - 0.54 9.6 22.0 0.81 9.1 9.1 3.0 1 1 2 3 3 3 0 Phage minor structural protein GP20 GDPD PF03009.12 ESA13546.1 - 0.54 9.7 4.6 0.71 9.3 3.1 1.3 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family IF-2B PF01008.12 ESA13546.1 - 0.56 9.1 5.6 0.69 8.8 3.7 1.3 1 1 0 1 1 1 0 Initiation factor 2 subunit family TMF_TATA_bd PF12325.3 ESA13546.1 - 0.84 9.3 29.3 3.5 7.3 2.7 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TPD52 PF04201.10 ESA13546.1 - 1.1 8.9 16.1 0.37 10.5 8.9 1.8 1 1 0 1 1 1 0 Tumour protein D52 family DUF972 PF06156.8 ESA13546.1 - 1.1 9.5 20.2 1.6 9.1 7.5 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TMCO5 PF14992.1 ESA13546.1 - 1.2 8.2 20.8 1.6 7.7 14.4 1.4 1 1 0 1 1 1 0 TMCO5 family FlaC_arch PF05377.6 ESA13546.1 - 1.4 8.9 19.7 4.7e+02 0.7 1.0 4.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) IncA PF04156.9 ESA13546.1 - 1.8 8.1 25.7 1.1 8.8 10.6 2.1 1 1 1 2 2 2 0 IncA protein CKAP2_C PF15297.1 ESA13546.1 - 2 7.1 18.1 1.1 7.9 2.0 1.9 1 1 1 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus Bap31 PF05529.7 ESA13546.1 - 2.3 7.6 16.0 0.17 11.3 6.2 2.3 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like DivIC PF04977.10 ESA13546.1 - 2.5 7.6 28.1 4.1 6.9 0.6 4.5 2 2 3 5 5 5 0 Septum formation initiator Syntaxin_2 PF14523.1 ESA13546.1 - 2.5 8.1 12.0 4.6 7.3 5.9 2.5 1 1 2 3 3 3 0 Syntaxin-like protein Prominin PF05478.6 ESA13546.1 - 2.6 5.4 7.1 3.3 5.1 4.7 1.5 1 1 0 1 1 1 0 Prominin Snapin_Pallidin PF14712.1 ESA13546.1 - 2.7 8.3 14.0 2.7 8.3 3.5 3.4 1 1 2 3 3 3 0 Snapin/Pallidin DivIVA PF05103.8 ESA13546.1 - 2.7 8.0 23.2 1.1 9.3 2.2 3.4 1 1 2 3 3 3 0 DivIVA protein CALCOCO1 PF07888.6 ESA13546.1 - 4.1 5.5 22.5 0.31 9.2 8.2 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Synaptobrevin PF00957.16 ESA13546.1 - 4.9 6.8 12.2 0.3 10.6 0.5 2.9 3 1 0 3 3 2 0 Synaptobrevin IFT57 PF10498.4 ESA13546.1 - 5.2 5.7 19.8 3.1 6.4 8.0 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF2229 PF09989.4 ESA13546.1 - 5.2 6.4 8.6 1.6 8.1 2.4 2.0 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) ACCA PF03255.9 ESA13546.1 - 5.9 6.4 13.0 5.1 6.6 3.6 3.1 1 1 2 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit 4HB_MCP_1 PF12729.2 ESA13546.1 - 6.2 6.1 18.3 1.3 8.3 4.5 2.8 1 1 2 3 3 3 0 Four helix bundle sensory module for signal transduction DUF904 PF06005.7 ESA13546.1 - 7 7.0 29.2 57 4.1 10.9 4.2 1 1 2 3 3 3 0 Protein of unknown function (DUF904) DUF2730 PF10805.3 ESA13546.1 - 7.6 6.3 15.4 1.1 9.0 3.9 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Laminin_II PF06009.7 ESA13546.1 - 8.3 6.1 14.0 9.1 6.0 2.9 2.6 1 1 1 2 2 2 0 Laminin Domain II Seryl_tRNA_N PF02403.17 ESA13546.1 - 9.5 6.2 23.6 7.1 6.6 9.7 3.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.6 ESA13546.1 - 9.8 6.1 12.2 19 5.1 0.3 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3847 PF12958.2 ESA13546.1 - 9.9 5.9 23.2 0.48 10.2 2.6 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF3847) Laminin_I PF06008.9 ESA13547.1 - 0.0073 15.6 6.3 0.01 15.2 4.4 1.1 1 0 0 1 1 1 1 Laminin Domain I eIF3g PF12353.3 ESA13547.1 - 0.019 14.8 8.1 0.023 14.6 0.6 2.7 1 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G ADIP PF11559.3 ESA13547.1 - 0.023 14.5 10.0 0.038 13.9 6.9 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding USP8_interact PF08941.5 ESA13547.1 - 0.029 13.6 0.7 0.029 13.6 0.5 2.0 1 1 1 2 2 2 0 USP8 interacting DUF4200 PF13863.1 ESA13547.1 - 0.03 14.2 14.9 0.056 13.3 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) SidE PF12252.3 ESA13547.1 - 0.032 11.5 2.6 0.037 11.3 1.8 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein V_ATPase_I PF01496.14 ESA13547.1 - 0.052 11.3 4.9 0.057 11.2 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.6 ESA13547.1 - 0.059 12.0 12.2 0.083 11.5 8.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF342 PF03961.8 ESA13547.1 - 0.062 11.7 7.2 0.072 11.4 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.7 ESA13547.1 - 0.16 11.1 0.3 0.18 10.9 0.2 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein bZIP_1 PF00170.16 ESA13547.1 - 0.2 11.6 12.9 1.3 8.9 2.0 2.5 2 0 0 2 2 2 0 bZIP transcription factor Bacillus_HBL PF05791.6 ESA13547.1 - 0.3 10.4 6.1 0.25 10.6 0.9 2.2 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) IncA PF04156.9 ESA13547.1 - 0.33 10.5 13.1 1.3 8.6 9.1 1.8 1 1 0 1 1 1 0 IncA protein DivIC PF04977.10 ESA13547.1 - 0.35 10.4 14.0 0.25 10.8 4.0 2.9 1 1 2 3 3 3 0 Septum formation initiator PEP-utilisers_N PF05524.8 ESA13547.1 - 0.46 10.2 3.6 0.55 10.0 1.7 1.7 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal TPR_MLP1_2 PF07926.7 ESA13547.1 - 0.47 10.2 12.8 1.5 8.5 8.9 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein SlyX PF04102.7 ESA13547.1 - 0.55 10.6 8.4 0.78 10.1 3.1 2.5 1 1 1 2 2 2 0 SlyX End3 PF12761.2 ESA13547.1 - 0.56 9.8 8.6 0.85 9.2 5.9 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 ATG16 PF08614.6 ESA13547.1 - 0.56 9.9 14.0 1.1 9.0 9.7 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) FlxA PF14282.1 ESA13547.1 - 0.59 10.1 9.2 12 5.9 6.4 2.4 1 1 0 1 1 1 0 FlxA-like protein DUF4618 PF15397.1 ESA13547.1 - 0.59 9.4 10.4 1.6 8.0 7.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) zf-C4H2 PF10146.4 ESA13547.1 - 0.68 9.9 12.2 1 9.3 8.0 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein HAUS-augmin3 PF14932.1 ESA13547.1 - 0.73 8.9 9.9 1 8.4 6.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Prefoldin PF02996.12 ESA13547.1 - 0.83 9.3 9.6 1.6 8.3 2.0 2.6 1 1 1 2 2 2 0 Prefoldin subunit zf-CCHC_3 PF13917.1 ESA13547.1 - 0.89 9.3 4.2 1.8 8.3 1.0 2.2 2 0 0 2 2 2 0 Zinc knuckle TBPIP PF07106.8 ESA13547.1 - 1.1 8.7 11.2 1.9 8.0 7.7 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) OmpH PF03938.9 ESA13547.1 - 1.2 9.0 8.5 1.6 8.6 5.9 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) eIF-4B PF06273.6 ESA13547.1 - 1.2 7.7 5.3 1.5 7.5 3.7 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B TMF_DNA_bd PF12329.3 ESA13547.1 - 1.6 8.6 20.8 0.84 9.4 5.7 2.7 2 1 1 3 3 2 0 TATA element modulatory factor 1 DNA binding TSC22 PF01166.13 ESA13547.1 - 1.7 8.6 11.0 0.34 10.8 0.6 3.0 1 1 1 2 2 2 0 TSC-22/dip/bun family Troponin PF00992.15 ESA13547.1 - 2 8.4 14.2 14 5.7 7.7 2.2 1 1 1 2 2 2 0 Troponin DUF2680 PF10925.3 ESA13547.1 - 2 8.3 4.8 33 4.4 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2680) TMPIT PF07851.8 ESA13547.1 - 2 7.3 4.3 2.8 6.9 3.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein APG6 PF04111.7 ESA13547.1 - 2.1 7.2 10.1 3.2 6.7 7.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF972 PF06156.8 ESA13547.1 - 2.5 8.4 10.0 1.5 9.2 4.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) zf-DBF PF07535.7 ESA13547.1 - 2.8 7.6 6.0 7.1 6.3 0.1 2.5 2 0 0 2 2 2 0 DBF zinc finger Spc24 PF08286.6 ESA13547.1 - 3 7.5 12.5 1.2 8.8 3.8 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Laminin_II PF06009.7 ESA13547.1 - 5 6.8 9.8 10 5.8 6.2 1.8 1 1 0 1 1 1 0 Laminin Domain II Pox_A_type_inc PF04508.7 ESA13547.1 - 6.1 6.8 21.1 0.57 10.1 0.8 4.2 3 1 0 3 3 3 0 Viral A-type inclusion protein repeat Wbp11 PF09429.5 ESA13547.1 - 8.6 6.4 11.5 6.3 6.8 2.2 2.4 1 1 1 2 2 2 0 WW domain binding protein 11 ACCA PF03255.9 ESA13547.1 - 9.2 5.8 9.3 18 4.8 2.4 2.2 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF4140 PF13600.1 ESA13547.1 - 9.3 6.7 10.2 3.9 7.9 2.4 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.7 ESA13547.1 - 9.6 6.0 7.3 31 4.3 5.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) SYCE1 PF15233.1 ESA13548.1 - 0.11 12.3 1.8 0.31 10.9 1.2 1.9 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 Polyketide_cyc PF03364.15 ESA13549.1 - 1.3e-17 64.0 0.0 1.6e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport zf-MYND PF01753.13 ESA13551.1 - 4.8e-08 32.7 19.7 4.8e-08 32.7 13.6 1.6 2 0 0 2 2 2 1 MYND finger P16-Arc PF04699.9 ESA13551.1 - 0.21 11.5 0.8 0.35 10.8 0.6 1.5 1 1 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) PolC_DP2 PF03833.8 ESA13551.1 - 1 6.9 4.7 0.99 6.9 3.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-Mss51 PF13824.1 ESA13551.1 - 1.5 8.7 9.7 2.7 7.9 6.7 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Ecl1 PF12855.2 ESA13551.1 - 1.9 7.8 15.8 3.9 6.8 10.9 1.5 1 0 0 1 1 1 0 Life-span regulatory factor zf-HIT PF04438.11 ESA13551.1 - 4.7 6.9 21.7 0.11 12.1 10.0 2.1 3 0 0 3 3 3 0 HIT zinc finger Metallothio PF00131.15 ESA13551.1 - 7 6.6 15.2 12 5.8 10.5 1.4 1 0 0 1 1 1 0 Metallothionein YfiO PF13525.1 ESA13553.1 - 0.0025 17.3 0.4 0.0028 17.1 0.3 1.1 1 0 0 1 1 1 1 Outer membrane lipoprotein Imm8 PF15560.1 ESA13554.1 - 0.048 13.3 0.3 0.061 12.9 0.2 1.2 1 0 0 1 1 1 0 Immunity protein 8 Beta_helix PF13229.1 ESA13554.1 - 0.14 11.8 0.7 0.18 11.5 0.1 1.5 2 0 0 2 2 2 0 Right handed beta helix region SAM_1 PF00536.25 ESA13555.1 - 0.0014 18.7 0.0 0.0039 17.3 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Amino_oxidase PF01593.19 ESA13555.1 - 0.017 14.2 0.0 0.021 13.9 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Exo_endo_phos PF03372.18 ESA13557.1 - 8.3e-23 81.5 0.0 1.2e-22 81.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PQQ_3 PF13570.1 ESA13557.1 - 0.57 10.5 8.8 15 6.0 0.0 5.5 7 0 0 7 7 7 0 PQQ-like domain PWWP PF00855.12 ESA13558.1 - 0.00018 21.6 0.9 0.00074 19.6 0.0 2.4 3 0 0 3 3 3 1 PWWP domain DZR PF12773.2 ESA13558.1 - 0.007 16.1 1.0 0.014 15.1 0.7 1.4 1 0 0 1 1 1 1 Double zinc ribbon DNApol3-delta_C PF09115.5 ESA13558.1 - 0.033 14.2 0.8 0.067 13.2 0.6 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal ABC2_membrane_3 PF12698.2 ESA13558.1 - 0.078 11.9 4.4 0.11 11.5 3.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein zinc_ribbon_2 PF13240.1 ESA13558.1 - 0.19 11.2 1.6 2 8.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain YhfH PF14149.1 ESA13558.1 - 0.74 9.6 2.9 2.4 8.0 0.1 2.3 2 0 0 2 2 2 0 YhfH-like protein NDUFB10 PF10249.4 ESA13559.1 - 3.2e-07 30.5 0.0 3.6e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 LRR_6 PF13516.1 ESA13560.1 - 3 8.1 6.0 23 5.4 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich repeat KRAB PF01352.22 ESA13561.1 - 0.16 11.4 0.4 0.3 10.5 0.0 1.6 2 0 0 2 2 2 0 KRAB box Dimer_Tnp_hAT PF05699.9 ESA13563.1 - 1.4e-12 47.0 0.2 1.5e-12 46.9 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sulfotransfer_1 PF00685.22 ESA13565.1 - 0.00037 19.8 0.2 0.00041 19.6 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 ESA13565.1 - 0.017 16.0 0.0 0.035 15.0 0.0 1.7 1 1 0 1 1 1 0 Sulfotransferase family Pkinase PF00069.20 ESA13566.1 - 7.1e-28 97.4 1.6 5.4e-26 91.2 1.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13566.1 - 5.5e-27 94.4 0.0 2.8e-25 88.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA13566.1 - 0.23 11.1 2.1 1.7 8.2 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA13567.1 - 8e-40 134.3 7.6 5.6e-11 42.7 0.7 5.3 5 0 0 5 5 5 5 Sel1 repeat Pkinase_Tyr PF07714.12 ESA13567.1 - 3.4e-33 114.8 0.0 6.4e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13567.1 - 9.4e-30 103.6 0.0 1.8e-29 102.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA13567.1 - 0.0003 19.9 0.1 0.0005 19.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA13567.1 - 0.00049 19.9 0.1 0.00073 19.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA13567.1 - 0.0023 17.3 0.1 0.0023 17.3 0.1 1.9 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA13567.1 - 0.044 12.7 0.0 0.069 12.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like MIT PF04212.13 ESA13567.1 - 1.6 8.6 8.2 10 6.1 0.2 4.4 4 2 0 4 4 4 0 MIT (microtubule interacting and transport) domain Suppressor_APC PF11414.3 ESA13570.1 - 0.0065 16.2 1.4 0.0083 15.8 1.0 1.2 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein TMCO5 PF14992.1 ESA13570.1 - 0.01 14.9 0.3 0.012 14.8 0.2 1.0 1 0 0 1 1 1 0 TMCO5 family GBS_Bsp-like PF08481.5 ESA13570.1 - 0.014 15.2 0.1 0.018 14.9 0.0 1.2 1 1 0 1 1 1 0 GBS Bsp-like repeat Bt_P21 PF05560.6 ESA13571.1 - 0.069 12.5 0.2 0.08 12.3 0.2 1.0 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein AMP-binding PF00501.23 ESA13572.1 - 8.6e-38 129.7 0.0 1.2e-37 129.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF4055 PF13264.1 ESA13573.1 - 0.093 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) p450 PF00067.17 ESA13574.1 - 2.1e-31 108.9 0.0 2.3e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA13574.1 - 0.0019 18.1 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1811) Sulfotransfer_1 PF00685.22 ESA13575.1 - 0.0003 20.1 0.3 0.0004 19.7 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase domain NmrA PF05368.8 ESA13576.1 - 3.9e-23 81.9 0.8 5e-23 81.5 0.5 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA13576.1 - 6.8e-06 26.2 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Methyltransf_11 PF08241.7 ESA13578.1 - 2.1e-10 40.9 0.0 4.3e-10 39.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA13578.1 - 1.4e-08 34.6 0.0 1.8e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13578.1 - 1.5e-08 34.4 0.0 0.0014 18.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.1 ESA13578.1 - 1.5e-08 34.8 0.0 4.8e-08 33.2 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA13578.1 - 4.2e-06 27.1 0.1 0.00066 20.1 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13578.1 - 9.1e-06 26.2 0.0 8.8e-05 23.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA13578.1 - 0.00016 21.6 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MetW PF07021.7 ESA13578.1 - 0.0017 17.8 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.13 ESA13578.1 - 0.003 16.8 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 ESA13578.1 - 0.0034 17.4 0.0 0.0092 16.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA13578.1 - 0.01 14.8 0.0 0.013 14.5 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 ESA13578.1 - 0.022 13.8 0.0 0.11 11.5 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 ESA13579.1 - 4.9e-16 59.0 0.0 1e-15 57.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA13579.1 - 1.2e-12 47.6 0.0 1.2e-11 44.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA13579.1 - 1.7e-12 47.3 0.0 2.7e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA13579.1 - 4.9e-10 39.7 0.0 1.1e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13579.1 - 1.3e-09 38.5 0.0 6.2e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA13579.1 - 3.3e-09 37.0 0.0 9.6e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA13579.1 - 1.4e-05 25.0 0.0 7.6e-05 22.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA13579.1 - 1.7e-05 24.0 0.0 6.2e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ESA13579.1 - 0.00037 19.9 0.0 0.00064 19.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 ESA13579.1 - 0.00041 20.3 0.0 0.00046 20.2 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 ESA13579.1 - 0.00053 19.0 0.0 0.0014 17.6 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_29 PF03141.11 ESA13579.1 - 0.015 13.6 0.0 0.055 11.8 0.0 1.7 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.13 ESA13579.1 - 0.026 13.7 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase CheR PF01739.13 ESA13579.1 - 0.066 12.5 0.0 0.56 9.4 0.0 2.1 1 1 0 2 2 2 0 CheR methyltransferase, SAM binding domain TehB PF03848.9 ESA13579.1 - 0.078 12.1 0.0 0.35 10.0 0.0 1.9 2 0 0 2 2 2 0 Tellurite resistance protein TehB Cu_bind_like PF02298.12 ESA13580.1 - 0.0086 15.8 0.5 0.098 12.4 0.3 2.2 1 1 0 1 1 1 1 Plastocyanin-like domain Copper-bind PF00127.15 ESA13580.1 - 0.057 13.6 0.5 0.092 12.9 0.3 1.4 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Ku PF02735.11 ESA13580.1 - 0.091 12.1 0.7 0.12 11.7 0.5 1.2 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain Sel1 PF08238.7 ESA13581.1 - 1.5e-87 286.1 17.8 4.1e-10 39.9 0.1 9.2 9 0 0 9 9 9 9 Sel1 repeat PRA-CH PF01502.13 ESA13583.1 - 0.033 13.8 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl-AMP cyclohydrolase COX7a PF02238.10 ESA13584.1 - 0.12 12.0 0.6 7 6.4 0.3 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIa DUF659 PF04937.10 ESA13584.1 - 0.14 11.6 3.3 0.6 9.5 0.3 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF 659) UDPGT PF00201.13 ESA13585.1 - 2.5e-23 82.3 0.0 5.4e-23 81.3 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA13585.1 - 1.3e-08 34.6 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA13585.1 - 0.00016 20.9 0.0 0.00028 20.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 1 Sigma_reg_C PF13791.1 ESA13585.1 - 0.081 12.9 0.4 1.1 9.3 0.1 2.2 2 0 0 2 2 2 0 Sigma factor regulator C-terminal DUF3718 PF12514.3 ESA13587.1 - 0.012 15.6 0.7 0.1 12.6 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3718) RRN3 PF05327.6 ESA13589.1 - 0.028 12.5 0.2 0.03 12.4 0.1 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2533 PF10752.4 ESA13589.1 - 0.095 13.0 0.2 0.19 12.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2533) tRNA_lig_kinase PF08303.6 ESA13593.1 - 8.5e-39 133.1 1.2 8.5e-39 133.1 0.8 1.8 2 0 0 2 2 2 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 ESA13593.1 - 5.1e-25 88.1 6.9 4.3e-24 85.1 4.8 2.1 1 1 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain KTI12 PF08433.5 ESA13593.1 - 0.00067 18.9 0.2 0.0012 18.1 0.1 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 ESA13593.1 - 0.0018 19.1 0.1 0.0093 16.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA13593.1 - 0.031 14.5 0.7 0.17 12.2 0.5 2.3 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA13593.1 - 0.093 12.6 0.2 0.35 10.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain Methyltransf_23 PF13489.1 ESA13593.1 - 0.095 12.4 0.0 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain TAF8_C PF10406.4 ESA13595.1 - 3.8e-15 55.6 2.9 1e-14 54.3 2.0 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.8 ESA13595.1 - 3.6e-10 39.4 0.1 5.7e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.19 ESA13595.1 - 0.00024 21.1 0.1 0.00044 20.3 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 U5_2-snRNA_bdg PF10597.4 ESA13595.1 - 0.018 14.6 1.1 1.7 8.2 0.3 2.5 1 1 1 2 2 2 0 U5-snRNA binding site 2 of PrP8 EBP PF05241.7 ESA13596.1 - 7.4e-53 178.4 5.2 9.9e-53 178.0 3.6 1.0 1 0 0 1 1 1 1 Emopamil binding protein NfeD PF01957.13 ESA13596.1 - 0.01 16.0 0.8 0.86 9.7 0.3 2.4 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF3307 PF11750.3 ESA13596.1 - 0.068 12.8 1.2 0.12 12.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3307) DUF2678 PF10856.3 ESA13596.1 - 0.12 12.1 0.9 0.73 9.5 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2678) DUF485 PF04341.7 ESA13596.1 - 4.8 6.9 5.8 4.4 7.0 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function, DUF485 Aa_trans PF01490.13 ESA13597.1 - 8e-72 241.9 31.8 1e-71 241.6 22.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PMP22_Claudin PF00822.15 ESA13597.1 - 0.0032 17.1 0.3 0.0032 17.1 0.2 3.4 4 1 1 5 5 5 1 PMP-22/EMP/MP20/Claudin family eIF-5_eIF-2B PF01873.12 ESA13598.1 - 1.1e-48 164.0 1.0 1.5e-48 163.5 0.7 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.7 ESA13598.1 - 0.022 14.0 0.3 0.039 13.2 0.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Casc1 PF12366.3 ESA13598.1 - 0.22 10.9 3.9 0.33 10.4 2.7 1.3 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 CN_hydrolase PF00795.17 ESA13599.1 - 2.8e-16 59.4 0.0 3.6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF3161 PF11362.3 ESA13600.1 - 5.2e-09 35.8 0.1 9.3e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3161) DUF1395 PF07160.7 ESA13600.1 - 4.4e-05 23.1 1.0 6.3e-05 22.5 0.6 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1395) Recep_L_domain PF01030.19 ESA13600.1 - 0.014 15.3 0.1 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Receptor L domain RED_N PF07808.8 ESA13600.1 - 0.056 12.6 2.6 0.078 12.1 1.8 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region Pkinase_Tyr PF07714.12 ESA13601.1 - 6.3e-36 123.7 0.0 9e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13601.1 - 1.7e-31 109.3 0.0 2.9e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain F-box-like PF12937.2 ESA13602.1 - 8e-05 22.2 0.1 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13602.1 - 0.011 15.4 1.6 0.066 12.8 1.1 2.2 1 1 0 1 1 1 0 F-box domain UDPGT PF00201.13 ESA13603.1 - 2e-23 82.7 0.0 3.2e-23 82.0 0.0 1.3 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA13603.1 - 7.4e-09 35.4 0.1 9.1e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA13603.1 - 8.2e-06 25.2 0.0 1.9e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 1 Sel1 PF08238.7 ESA13604.1 - 1.4e-116 378.3 38.0 2.4e-10 40.6 0.1 13.1 13 0 0 13 13 13 13 Sel1 repeat TPR_11 PF13414.1 ESA13604.1 - 1.9e-05 24.1 55.2 0.068 12.8 2.1 9.8 2 1 9 11 11 11 8 TPR repeat PrgU PF09627.5 ESA13604.1 - 0.032 13.8 0.6 3.8 7.1 0.0 3.4 4 0 0 4 4 4 0 PrgU-like protein MIT PF04212.13 ESA13604.1 - 0.39 10.6 54.7 1.7 8.5 1.2 10.9 3 3 9 12 12 12 0 MIT (microtubule interacting and transport) domain AIG1 PF04548.11 ESA13606.1 - 2.2e-09 36.7 0.0 2.6e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA13606.1 - 4.2e-05 23.4 0.0 0.00017 21.5 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.13 ESA13606.1 - 0.00039 19.5 0.1 0.00072 18.6 0.1 1.3 1 0 0 1 1 1 1 Septin DUF258 PF03193.11 ESA13606.1 - 0.00044 19.4 0.1 0.0011 18.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 RNA_helicase PF00910.17 ESA13606.1 - 0.00057 20.0 0.0 0.0012 18.9 0.0 1.5 2 0 0 2 2 2 1 RNA helicase Miro PF08477.8 ESA13606.1 - 0.012 16.1 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein DUF659 PF04937.10 ESA13606.1 - 0.016 14.6 0.0 0.052 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Dynamin_N PF00350.18 ESA13606.1 - 0.022 14.5 0.1 0.049 13.4 0.1 2.0 1 1 0 1 1 1 0 Dynamin family ABC_tran PF00005.22 ESA13606.1 - 0.023 14.9 0.2 0.03 14.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.13 ESA13606.1 - 0.082 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 ESA13606.1 - 0.092 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.1 ESA13606.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain p450 PF00067.17 ESA13607.1 - 2.7e-35 121.7 0.0 3e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 N6_Mtase PF02384.11 ESA13608.1 - 0.051 12.6 0.8 0.08 12.0 0.5 1.4 1 1 0 1 1 1 0 N-6 DNA Methylase ABC_sub_bind PF04392.7 ESA13609.1 - 0.014 14.3 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter substrate binding protein Uma2 PF05685.7 ESA13612.1 - 4e-12 45.8 0.0 6.3e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease Pkinase_Tyr PF07714.12 ESA13612.1 - 0.00023 20.3 0.0 0.00038 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AAA-ATPase_like PF09820.4 ESA13615.1 - 3.2e-52 177.4 9.5 3.2e-52 177.4 6.6 1.6 2 0 0 2 2 2 1 Predicted AAA-ATPase DUF1703 PF08011.6 ESA13615.1 - 3e-15 55.8 1.1 5.7e-15 54.9 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1703) Peptidase_C48 PF02902.14 ESA13616.1 - 1.4e-24 86.8 4.1 4.6e-24 85.2 2.9 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Hydrolase_3 PF08282.7 ESA13616.1 - 0.035 13.6 0.7 0.078 12.5 0.5 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_C48 PF02902.14 ESA13617.1 - 3.8e-19 69.1 0.9 1.2e-18 67.4 0.6 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain MULE PF10551.4 ESA13618.1 - 0.026 14.6 0.9 0.039 14.1 0.7 1.3 1 0 0 1 1 1 0 MULE transposase domain Pkinase PF00069.20 ESA13619.1 - 0.013 14.6 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13619.1 - 0.049 12.6 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2264 PF10022.4 ESA13620.1 - 0.028 13.1 0.1 0.044 12.4 0.0 1.2 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) DUF3872 PF12988.2 ESA13620.1 - 0.094 12.2 0.5 0.16 11.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) 7TM_GPCR_Srd PF10317.4 ESA13620.1 - 0.41 9.5 4.5 0.27 10.2 0.8 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srd Pkinase_Tyr PF07714.12 ESA13621.1 - 1.3e-44 152.2 0.0 2e-44 151.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13621.1 - 2.1e-39 135.2 0.1 3.6e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain GATA PF00320.22 ESA13621.1 - 9.1 5.7 9.9 4.1 6.8 0.0 3.4 2 1 1 3 3 3 0 GATA zinc finger DUF1601 PF07671.6 ESA13622.1 - 0.021 14.4 0.1 0.061 12.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1601) PP-binding PF00550.20 ESA13623.1 - 0.028 14.6 0.0 0.034 14.4 0.0 1.1 1 0 0 1 1 1 0 Phosphopantetheine attachment site AMP-binding PF00501.23 ESA13624.1 - 1e-38 132.8 0.0 2e-38 131.9 0.0 1.5 1 1 0 1 1 1 1 AMP-binding enzyme AAA_22 PF13401.1 ESA13628.1 - 0.076 13.1 0.3 0.2 11.7 0.2 1.7 1 1 0 1 1 1 0 AAA domain DUF2353 PF09789.4 ESA13629.1 - 0.0038 16.5 12.2 0.0067 15.7 8.4 1.4 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) CALCOCO1 PF07888.6 ESA13629.1 - 0.055 11.7 14.3 0.068 11.4 9.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Apolipoprotein PF01442.13 ESA13629.1 - 0.07 12.6 8.8 0.25 10.8 6.1 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF2968 PF11180.3 ESA13629.1 - 0.25 10.6 11.9 0.54 9.6 8.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Nup54 PF13874.1 ESA13629.1 - 0.57 9.8 14.1 2.1 8.0 9.0 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 bZIP_1 PF00170.16 ESA13629.1 - 0.79 9.7 13.9 1.3 9.0 7.5 2.7 2 0 0 2 2 2 0 bZIP transcription factor SecA_PP_bind PF01043.15 ESA13629.1 - 1 9.7 10.5 0.33 11.3 4.7 2.1 1 1 1 2 2 2 0 SecA preprotein cross-linking domain UPF0449 PF15136.1 ESA13629.1 - 6.1 7.1 10.2 6.9 6.9 4.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 P4Ha_N PF08336.6 ESA13629.1 - 6.6 6.5 15.0 5.3 6.8 6.6 2.4 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region tRNA_bind_2 PF13725.1 ESA13629.1 - 9.9 6.3 7.5 9.1 6.4 3.8 1.9 1 1 1 2 2 2 0 Possible tRNA binding domain DUF4614 PF15391.1 ESA13630.1 - 0.088 12.5 0.4 0.14 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Abhydrolase_3 PF07859.8 ESA13631.1 - 6.2e-27 94.5 0.0 1.1e-21 77.4 0.0 2.5 2 1 1 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA13631.1 - 2.6e-19 69.1 0.0 1.4e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA13631.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family NDUFA12 PF05071.11 ESA13633.1 - 0.073 13.5 0.5 0.1 13.0 0.4 1.3 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 Nup88 PF10168.4 ESA13633.1 - 0.12 10.1 1.4 0.15 9.9 1.0 1.0 1 0 0 1 1 1 0 Nuclear pore component Ribosomal_L30_N PF08079.7 ESA13633.1 - 0.17 11.9 3.4 0.19 11.7 1.8 1.5 1 1 1 2 2 2 0 Ribosomal L30 N-terminal domain F-box-like PF12937.2 ESA13634.1 - 0.00085 18.9 0.6 0.0033 17.1 0.0 2.3 2 0 0 2 2 2 1 F-box-like DUF874 PF05917.6 ESA13634.1 - 0.031 13.1 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) DDE_Tnp_4 PF13359.1 ESA13635.1 - 3.2e-14 52.8 0.0 3.7e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.9 ESA13635.1 - 7e-06 25.5 0.1 8.8e-06 25.2 0.1 1.1 1 0 0 1 1 1 1 Plant transposon protein Branch PF02485.16 ESA13635.1 - 0.069 12.3 0.1 0.088 11.9 0.1 1.0 1 0 0 1 1 1 0 Core-2/I-Branching enzyme Dimer_Tnp_hAT PF05699.9 ESA13636.1 - 5.2e-05 22.7 0.2 0.00015 21.2 0.1 1.8 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region MazG-like PF12643.2 ESA13636.1 - 0.06 13.2 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 MazG-like family YSIRK_signal PF04650.12 ESA13637.1 - 3 7.4 5.2 0.67 9.5 1.4 1.7 2 0 0 2 2 2 0 YSIRK type signal peptide TROVE PF05731.6 ESA13639.1 - 0.0062 15.3 2.5 0.0079 15.0 1.7 1.1 1 0 0 1 1 1 1 TROVE domain ELH PF02323.10 ESA13639.1 - 0.031 13.4 2.0 0.14 11.3 0.4 2.1 1 1 1 2 2 2 0 Egg-laying hormone precursor F-protein PF00469.15 ESA13639.1 - 0.19 11.0 3.5 0.24 10.7 2.4 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef cwf21 PF08312.7 ESA13639.1 - 1.4 8.7 4.3 1.3 8.9 1.5 2.1 2 1 0 2 2 2 0 cwf21 domain BTB PF00651.26 ESA13640.1 - 5.1e-15 55.4 0.0 1.3e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13640.1 - 1.8e-11 43.7 5.9 4e-08 33.0 0.4 4.1 4 0 0 4 4 4 3 BTB And C-terminal Kelch Urm1 PF09138.6 ESA13640.1 - 0.11 12.6 0.7 0.5 10.5 0.5 2.1 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) BACK PF07707.10 ESA13641.1 - 1e-11 44.5 0.4 6.9e-09 35.4 0.1 2.5 2 0 0 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.26 ESA13641.1 - 1.7e-10 40.8 0.0 3.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-DHHC PF01529.15 ESA13642.1 - 0.041 13.2 0.6 0.046 13.1 0.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase HemY_N PF07219.8 ESA13642.1 - 0.11 12.0 0.2 0.11 12.0 0.2 1.4 2 0 0 2 2 2 0 HemY protein N-terminus DUF2344 PF10105.4 ESA13643.1 - 0.031 13.7 0.1 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Aldo_ket_red PF00248.16 ESA13645.1 - 1e-17 63.8 0.0 1.6e-17 63.2 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family VP_N-CPKC PF11475.3 ESA13646.1 - 0.16 11.5 1.5 7.9 6.1 0.1 2.4 2 0 0 2 2 2 0 Virion protein N terminal domain GRAM PF02893.15 ESA13647.1 - 1.1e-13 50.5 0.2 2.2e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 GRAM domain ISN1 PF06437.6 ESA13648.1 - 3.3e-133 444.3 0.0 4e-133 444.0 0.0 1.1 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DPBB_1 PF03330.13 ESA13648.1 - 4.2e-10 39.4 0.1 8.4e-10 38.5 0.1 1.5 1 0 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 ESA13648.1 - 5.5e-05 22.8 0.7 0.00011 21.9 0.5 1.4 1 0 0 1 1 1 1 Barwin family RICTOR_N PF14664.1 ESA13648.1 - 0.052 12.1 0.0 0.09 11.3 0.0 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term Pkinase PF00069.20 ESA13649.1 - 9e-26 90.5 0.8 9e-26 90.5 0.6 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13649.1 - 1.8e-25 89.5 0.0 2.4e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA13649.1 - 0.0061 16.3 0.3 0.012 15.4 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-UBR PF02207.15 ESA13649.1 - 0.11 12.2 2.0 0.24 11.1 1.4 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DZR PF12773.2 ESA13649.1 - 0.13 12.1 0.8 0.21 11.4 0.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.1 ESA13649.1 - 0.68 10.3 5.9 1.3 9.4 4.1 1.4 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Fungal_trans PF04082.13 ESA13652.1 - 4e-35 120.9 0.2 4e-35 120.9 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ESA13652.1 - 3e-11 43.0 12.1 3e-11 43.0 8.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRK PF00485.13 ESA13652.1 - 0.7 9.4 2.8 1.8 8.1 1.9 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Ku_PK_bind PF08785.6 ESA13657.1 - 0.041 13.7 3.1 0.086 12.7 1.2 2.1 2 0 0 2 2 2 0 Ku C terminal domain like SSV1_ORF_D-335 PF07935.6 ESA13657.1 - 0.1 12.3 0.8 0.88 9.3 0.1 2.4 2 0 0 2 2 2 0 ORF D-335-like protein SAM_PNT PF02198.11 ESA13658.1 - 1.7e-05 24.4 0.0 3.8e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain DUF577 PF04510.7 ESA13658.1 - 0.044 13.4 0.4 0.073 12.7 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF577) DPCD PF14913.1 ESA13659.1 - 2.3 7.2 9.3 0.25 10.4 2.2 2.2 2 0 0 2 2 2 0 DPCD protein family F-box-like PF12937.2 ESA13660.1 - 0.0029 17.2 0.7 0.0067 16.1 0.5 1.6 1 0 0 1 1 1 1 F-box-like BTB PF00651.26 ESA13662.1 - 9.3e-14 51.3 0.2 3.1e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA13662.1 - 6.7e-07 29.1 5.4 0.00033 20.4 0.7 3.5 3 2 0 3 3 3 2 BTB And C-terminal Kelch RNA_pol_L_2 PF13656.1 ESA13662.1 - 0.012 15.0 0.1 7.1 6.1 0.0 2.9 2 1 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain PBP1_TM PF14812.1 ESA13666.1 - 0.0045 17.2 0.7 0.0046 17.2 0.5 1.0 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF912 PF06024.7 ESA13666.1 - 0.1 12.6 3.3 0.11 12.5 2.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ETRAMP PF09716.5 ESA13666.1 - 0.29 11.1 6.8 0.46 10.4 4.7 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) T-box PF00907.17 ESA13668.1 - 8.5e-45 152.4 3.1 2e-42 144.7 2.1 3.2 1 1 0 1 1 1 1 T-box TIM PF00121.13 ESA13669.1 - 1.1e-93 312.7 0.8 1.3e-93 312.5 0.6 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.9 ESA13669.1 - 0.00075 18.8 0.1 0.041 13.1 0.0 2.1 1 1 1 2 2 2 2 CutC family MreB_Mbl PF06723.8 ESA13669.1 - 0.002 16.8 0.0 0.27 9.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Phage_int_SAM_2 PF12834.2 ESA13669.1 - 0.051 13.9 0.1 0.37 11.2 0.0 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal Methyltransf_16 PF10294.4 ESA13670.1 - 1.3e-28 99.5 0.2 2e-28 99.0 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 ESA13670.1 - 1.8e-06 27.7 0.0 2.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13670.1 - 0.0014 19.2 0.0 0.0022 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA13670.1 - 0.0055 16.0 0.0 0.0082 15.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 ESA13670.1 - 0.01 15.0 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESA13670.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESA13670.1 - 0.029 14.8 0.0 0.096 13.1 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Proteasome PF00227.21 ESA13671.1 - 8.5e-64 214.3 0.1 1.1e-63 214.0 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA13671.1 - 4e-15 54.7 0.1 9.6e-15 53.5 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature FlxA PF14282.1 ESA13672.1 - 0.058 13.3 1.0 0.058 13.3 0.7 2.1 3 0 0 3 3 3 0 FlxA-like protein Snapin_Pallidin PF14712.1 ESA13672.1 - 0.15 12.4 4.9 0.27 11.5 3.0 1.8 1 1 0 1 1 1 0 Snapin/Pallidin AAA_13 PF13166.1 ESA13672.1 - 0.22 9.9 7.7 0.28 9.6 5.3 1.1 1 0 0 1 1 1 0 AAA domain Striatin PF08232.7 ESA13672.1 - 7.2 6.9 10.8 11 6.3 3.3 2.5 2 1 0 2 2 2 0 Striatin family F-box-like PF12937.2 ESA13675.1 - 1.9e-08 33.9 0.9 3.7e-08 32.9 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA13675.1 - 7.2e-06 25.5 1.1 7.2e-06 25.5 0.8 2.0 2 0 0 2 2 2 1 F-box domain BTB PF00651.26 ESA13676.1 - 9.4e-19 67.4 0.0 1.1e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain LisH PF08513.6 ESA13677.1 - 0.081 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 LisH Pkinase PF00069.20 ESA13678.1 - 4.5e-13 48.9 0.5 6.3e-13 48.4 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13678.1 - 2.9e-08 33.0 0.0 2.2e-07 30.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L18_c PF14204.1 ESA13680.1 - 1.9 9.0 7.8 0.37 11.3 2.0 2.2 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region BTB PF00651.26 ESA13681.1 - 5.6e-17 61.7 1.0 2.1e-16 59.9 0.7 1.8 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13681.1 - 0.026 14.3 1.4 3 7.7 0.0 3.1 1 1 2 3 3 3 0 BTB And C-terminal Kelch FancD2 PF14631.1 ESA13682.1 - 4.2e-222 740.0 29.1 6.2e-222 739.4 20.2 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease MA3 PF02847.12 ESA13682.1 - 0.02 14.6 4.5 0.12 12.1 0.2 3.7 2 1 1 3 3 3 0 MA3 domain Alginate_lyase PF05426.7 ESA13683.1 - 5.4e-70 235.8 0.0 7.2e-70 235.4 0.0 1.2 1 0 0 1 1 1 1 Alginate lyase RNA_pol_Rpc4 PF05132.9 ESA13684.1 - 5.4e-13 49.0 0.9 1e-12 48.1 0.0 1.9 2 1 0 2 2 2 1 RNA polymerase III RPC4 PP1c_bdg PF10488.4 ESA13684.1 - 0.1 11.7 0.7 0.13 11.4 0.5 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region PMT PF02366.13 ESA13686.1 - 2.9e-80 269.1 23.4 2.9e-80 269.1 16.2 2.2 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 ESA13686.1 - 2.9e-33 114.9 2.2 3.9e-33 114.5 1.5 1.2 1 0 0 1 1 1 1 MIR domain BTB PF00651.26 ESA13687.1 - 1.7e-19 69.8 0.1 1.1e-18 67.2 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain EzrA PF06160.7 ESA13688.1 - 0.0033 15.6 12.6 0.0033 15.6 8.7 1.8 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA Fis1_TPR_C PF14853.1 ESA13688.1 - 0.14 12.1 0.5 0.14 12.1 0.3 2.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_MLP1_2 PF07926.7 ESA13688.1 - 0.14 11.9 23.0 0.054 13.2 13.4 1.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF2096 PF09869.4 ESA13688.1 - 0.17 11.7 9.6 0.2 11.5 6.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) Fib_alpha PF08702.5 ESA13688.1 - 0.2 11.7 16.3 0.52 10.4 4.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family WEMBL PF05701.6 ESA13688.1 - 0.23 9.8 24.3 0.47 8.8 16.8 1.5 1 1 0 1 1 1 0 Weak chloroplast movement under blue light CENP-F_leu_zip PF10473.4 ESA13688.1 - 0.48 10.2 23.3 0.7 9.7 16.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF932 PF06067.6 ESA13688.1 - 0.56 9.4 5.7 0.67 9.2 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF932) DUF4407 PF14362.1 ESA13688.1 - 0.58 9.0 10.6 0.78 8.6 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) She9_MDM33 PF05546.6 ESA13688.1 - 0.67 9.4 15.4 0.38 10.2 2.3 2.2 1 1 1 2 2 2 0 She9 / Mdm33 family DUF3394 PF11874.3 ESA13688.1 - 1 8.8 4.4 0.91 9.0 1.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3394) IncA PF04156.9 ESA13688.1 - 1.5 8.3 20.6 2 7.9 14.3 1.2 1 0 0 1 1 1 0 IncA protein Cortex-I_coil PF09304.5 ESA13688.1 - 1.6 8.7 23.1 1.5 8.8 8.8 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil LRS4 PF10422.4 ESA13688.1 - 1.7 7.9 18.4 1.9 7.7 12.7 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 OEP PF02321.13 ESA13688.1 - 1.9 8.0 19.1 16 5.0 13.2 2.0 1 1 0 1 1 1 0 Outer membrane efflux protein APG6 PF04111.7 ESA13688.1 - 1.9 7.4 20.3 2.4 7.1 14.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 YscO PF07321.7 ESA13688.1 - 2.6 7.8 21.6 5.5 6.8 15.0 1.5 1 1 0 1 1 1 0 Type III secretion protein YscO DUF2968 PF11180.3 ESA13688.1 - 3 7.1 14.0 1.8 7.9 8.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) DUF3584 PF12128.3 ESA13688.1 - 3.4 4.8 18.5 4 4.6 12.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.1 ESA13688.1 - 4.3 6.4 24.8 7.3 5.7 17.1 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 ESA13688.1 - 5.9 5.2 17.3 8.3 4.7 12.0 1.3 1 0 0 1 1 1 0 AAA domain ADIP PF11559.3 ESA13688.1 - 7.3 6.4 22.7 1.2 9.0 10.8 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.6 ESA13688.1 - 9.3 4.7 21.7 21 3.6 15.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein ADIP PF11559.3 ESA13689.1 - 0.0018 18.1 14.9 0.0022 17.8 10.3 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Snapin_Pallidin PF14712.1 ESA13689.1 - 0.086 13.1 9.5 0.031 14.5 4.2 1.9 1 1 0 2 2 2 0 Snapin/Pallidin Rootletin PF15035.1 ESA13689.1 - 0.13 12.1 9.5 0.44 10.5 6.6 1.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF2009 PF09418.5 ESA13689.1 - 0.17 10.5 2.2 0.19 10.4 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) V_ATPase_I PF01496.14 ESA13689.1 - 0.3 8.9 9.6 0.33 8.7 6.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.7 ESA13689.1 - 0.72 9.6 5.1 0.42 10.4 1.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Phe_tRNA-synt_N PF02912.13 ESA13689.1 - 1.3 8.8 8.0 0.91 9.2 0.7 2.6 1 1 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Mgr1 PF08602.5 ESA13689.1 - 1.9 7.4 7.0 2.1 7.3 4.9 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit SlyX PF04102.7 ESA13689.1 - 2.2 8.7 8.6 1.4 9.3 1.2 2.4 1 1 1 2 2 2 0 SlyX DUF2997 PF11211.3 ESA13689.1 - 3.4 7.1 4.9 6.6 6.2 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2997) Atg14 PF10186.4 ESA13689.1 - 3.6 6.4 11.5 2 7.2 6.2 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Troponin PF00992.15 ESA13689.1 - 3.9 7.5 13.7 10 6.1 9.5 1.7 1 1 0 1 1 1 0 Troponin TMF_DNA_bd PF12329.3 ESA13689.1 - 5.2 6.9 22.0 2.2 8.1 2.0 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF342 PF03961.8 ESA13689.1 - 8.3 4.7 11.9 8.6 4.6 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IncA PF04156.9 ESA13689.1 - 8.4 5.9 15.5 20 4.6 10.7 1.7 1 1 0 1 1 1 0 IncA protein Fib_alpha PF08702.5 ESA13689.1 - 9.5 6.3 10.1 5.1 7.1 2.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Kinesin PF00225.18 ESA13690.1 - 6.3e-48 163.1 0.7 1.8e-47 161.7 0.5 1.6 1 1 0 1 1 1 1 Kinesin motor domain Sel1 PF08238.7 ESA13691.1 - 2.1e-37 126.6 9.6 9.8e-14 51.4 0.9 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_11 PF13414.1 ESA13691.1 - 1.3e-06 27.9 10.7 0.0031 17.1 1.9 2.7 1 1 2 3 3 3 3 TPR repeat TPR_17 PF13431.1 ESA13691.1 - 2.3e-05 24.2 2.5 0.08 13.1 0.1 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.13 ESA13691.1 - 0.0001 22.0 6.4 0.13 12.2 0.2 3.4 3 1 1 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESA13691.1 - 0.00018 22.0 0.1 0.084 13.5 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA13691.1 - 0.00027 21.1 2.9 0.02 15.3 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA13691.1 - 0.0028 17.3 0.3 4.4 7.1 0.0 3.4 4 0 0 4 4 4 1 Lung surfactant protein D coiled-coil trimerisation TPR_1 PF00515.23 ESA13691.1 - 0.003 17.0 13.4 2.8 7.7 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA13691.1 - 0.017 15.0 14.5 2.1 8.4 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA13691.1 - 0.017 15.0 8.8 0.9 9.5 1.4 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA13691.1 - 0.25 11.7 1.9 28 5.1 0.2 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA13691.1 - 4.4 7.3 12.3 15 5.6 1.1 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.24 ESA13694.1 - 6.1e-05 22.5 0.1 6.8e-05 22.4 0.1 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2620 PF10941.3 ESA13694.1 - 0.092 12.7 0.0 0.1 12.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF2620 NPV_P10 PF05531.7 ESA13697.1 - 8.5e-05 22.7 0.2 0.00013 22.1 0.2 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Syntaxin_2 PF14523.1 ESA13697.1 - 0.00081 19.3 0.9 0.0013 18.7 0.6 1.3 1 0 0 1 1 1 1 Syntaxin-like protein Baculo_PEP_C PF04513.7 ESA13697.1 - 0.00092 19.0 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2730 PF10805.3 ESA13697.1 - 0.0016 18.1 0.9 1.7 8.4 0.1 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF2730) DUF948 PF06103.6 ESA13697.1 - 0.0035 17.1 1.5 0.02 14.7 0.9 1.9 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) TBPIP PF07106.8 ESA13697.1 - 0.0039 16.7 1.1 0.0054 16.3 0.8 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Tropomyosin_1 PF12718.2 ESA13697.1 - 0.0042 16.9 0.8 0.0058 16.4 0.5 1.1 1 0 0 1 1 1 1 Tropomyosin like TPD52 PF04201.10 ESA13697.1 - 0.0058 16.3 2.2 0.0087 15.8 1.6 1.2 1 0 0 1 1 1 1 Tumour protein D52 family Laminin_II PF06009.7 ESA13697.1 - 0.0059 16.3 1.6 0.2 11.3 0.1 2.1 1 1 1 2 2 2 1 Laminin Domain II Seryl_tRNA_N PF02403.17 ESA13697.1 - 0.0072 16.3 3.3 0.014 15.3 2.3 1.5 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.1 ESA13697.1 - 0.0089 14.5 0.4 0.01 14.3 0.3 1.0 1 0 0 1 1 1 1 AAA domain SF-assemblin PF06705.6 ESA13697.1 - 0.0091 15.1 0.4 0.012 14.8 0.3 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Filament PF00038.16 ESA13697.1 - 0.011 15.2 0.1 0.014 14.9 0.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF1664 PF07889.7 ESA13697.1 - 0.013 15.3 0.4 0.021 14.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2353 PF09789.4 ESA13697.1 - 0.015 14.5 0.3 0.018 14.3 0.2 1.0 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Lectin_N PF03954.9 ESA13697.1 - 0.016 14.6 0.1 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain ApoLp-III PF07464.6 ESA13697.1 - 0.018 15.0 0.5 0.024 14.6 0.4 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Prefoldin_2 PF01920.15 ESA13697.1 - 0.019 14.7 3.7 0.048 13.4 2.5 1.7 1 1 0 1 1 1 0 Prefoldin subunit BLOC1_2 PF10046.4 ESA13697.1 - 0.022 14.8 0.4 0.034 14.2 0.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG2 PF06148.6 ESA13697.1 - 0.022 14.6 1.1 0.22 11.3 0.7 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Gp58 PF07902.6 ESA13697.1 - 0.023 12.9 0.1 0.026 12.7 0.0 1.0 1 0 0 1 1 1 0 gp58-like protein LXG PF04740.7 ESA13697.1 - 0.024 14.4 0.1 0.028 14.1 0.1 1.1 1 0 0 1 1 1 0 LXG domain of WXG superfamily Reo_sigmaC PF04582.7 ESA13697.1 - 0.024 13.8 0.0 0.029 13.5 0.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF1640 PF07798.6 ESA13697.1 - 0.025 14.6 0.5 0.03 14.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Spc7 PF08317.6 ESA13697.1 - 0.025 13.2 0.5 0.036 12.7 0.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DNA_repr_REX1B PF14966.1 ESA13697.1 - 0.028 14.7 0.0 0.12 12.7 0.0 1.8 1 1 0 1 1 1 0 DNA repair REX1-B NRN1 PF15056.1 ESA13697.1 - 0.029 14.3 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 Neuritin protein family Matrilin_ccoil PF10393.4 ESA13697.1 - 0.032 13.5 2.8 0.48 9.8 0.1 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Laminin_I PF06008.9 ESA13697.1 - 0.034 13.4 0.5 0.038 13.3 0.3 1.1 1 0 0 1 1 1 0 Laminin Domain I BicD PF09730.4 ESA13697.1 - 0.035 12.4 0.3 0.042 12.2 0.2 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D GCN5L1 PF06320.8 ESA13697.1 - 0.045 13.5 0.4 0.17 11.7 0.1 1.9 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) EzrA PF06160.7 ESA13697.1 - 0.047 11.8 0.2 0.057 11.5 0.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA IFT57 PF10498.4 ESA13697.1 - 0.049 12.3 1.6 0.29 9.8 1.3 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 TPR_MLP1_2 PF07926.7 ESA13697.1 - 0.055 13.2 0.2 0.066 12.9 0.1 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.4 ESA13697.1 - 0.057 13.6 0.1 0.077 13.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) HemX PF04375.9 ESA13697.1 - 0.07 11.7 0.1 0.087 11.4 0.1 1.1 1 0 0 1 1 1 0 HemX MAD PF05557.8 ESA13697.1 - 0.073 11.1 1.6 0.089 10.8 1.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein RmuC PF02646.11 ESA13697.1 - 0.08 11.7 1.3 0.13 11.0 0.9 1.4 1 1 0 1 1 1 0 RmuC family TMF_DNA_bd PF12329.3 ESA13697.1 - 0.097 12.4 8.0 0.76 9.6 1.2 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Bacillus_HBL PF05791.6 ESA13697.1 - 0.11 11.8 0.5 0.16 11.3 0.3 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Val_tRNA-synt_C PF10458.4 ESA13697.1 - 0.13 12.3 3.7 5.4 7.1 0.2 2.3 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Tektin PF03148.9 ESA13697.1 - 0.14 10.6 0.3 0.18 10.3 0.2 1.1 1 0 0 1 1 1 0 Tektin family H-kinase_dim PF02895.9 ESA13697.1 - 0.14 12.4 0.3 0.23 11.8 0.2 1.3 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Sec8_exocyst PF04048.9 ESA13697.1 - 0.21 11.1 2.0 5.5 6.6 0.1 2.1 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF1090 PF06476.7 ESA13697.1 - 0.26 10.9 1.8 0.36 10.5 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF3496 PF12001.3 ESA13697.1 - 0.32 11.2 2.4 1 9.6 1.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3496) FlaC_arch PF05377.6 ESA13697.1 - 1.3 8.9 3.9 4.9 7.1 2.7 2.0 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Ank PF00023.25 ESA13698.1 - 4.4e-25 86.1 3.3 1.6e-08 33.8 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 ESA13698.1 - 5e-25 87.6 0.1 6.8e-18 64.7 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESA13698.1 - 2.1e-17 62.7 0.6 2.6e-08 33.8 0.0 4.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA13698.1 - 1.5e-16 58.8 1.3 0.00019 21.3 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 ESA13698.1 - 8.3e-16 58.0 0.7 2.3e-06 27.9 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF3447 PF11929.3 ESA13698.1 - 0.05 13.3 0.0 5.8 6.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) NTP_transf_2 PF01909.18 ESA13698.1 - 0.096 13.0 0.1 0.75 10.1 0.0 2.5 3 0 0 3 3 3 0 Nucleotidyltransferase domain DUF1635 PF07795.6 ESA13698.1 - 0.25 10.6 6.5 0.48 9.7 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Dimer_Tnp_hAT PF05699.9 ESA13699.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.5 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region Na_Ca_ex PF01699.19 ESA13701.1 - 3.2e-13 49.4 8.7 3.8e-13 49.2 6.0 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF3981 PF13139.1 ESA13701.1 - 0.33 10.9 6.1 5.3 7.0 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3981) Hrs_helical PF12210.3 ESA13702.1 - 0.0042 17.2 1.4 0.0056 16.8 0.8 1.4 1 1 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate GAS PF13851.1 ESA13702.1 - 0.01 15.0 19.2 0.011 14.9 13.3 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Tweety PF04906.8 ESA13702.1 - 0.015 13.7 1.5 0.017 13.5 1.0 1.0 1 0 0 1 1 1 0 Tweety ATG16 PF08614.6 ESA13702.1 - 0.02 14.7 15.5 0.038 13.8 5.8 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SH3BP5 PF05276.9 ESA13702.1 - 0.023 13.9 9.4 0.043 13.1 6.5 1.5 1 1 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) DUF3450 PF11932.3 ESA13702.1 - 0.032 13.5 6.4 0.07 12.3 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Kinesin-relat_1 PF12711.2 ESA13702.1 - 0.048 14.0 11.8 1.2 9.5 3.0 2.3 1 1 1 2 2 2 0 Kinesin motor Viral_P18 PF04521.8 ESA13702.1 - 0.056 12.8 5.5 0.22 10.9 3.4 1.9 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein TMF_TATA_bd PF12325.3 ESA13702.1 - 0.064 12.9 17.1 0.25 11.0 3.2 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding HALZ PF02183.13 ESA13702.1 - 0.098 12.3 0.7 0.098 12.3 0.5 3.0 1 1 1 2 2 2 0 Homeobox associated leucine zipper Lge1 PF11488.3 ESA13702.1 - 0.11 12.6 12.5 0.71 10.0 4.7 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Gp_UL130 PF11668.3 ESA13702.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 1 0 1 1 1 0 HCMV glycoprotein pUL130 Fib_alpha PF08702.5 ESA13702.1 - 0.16 12.1 8.5 1.5 8.9 5.9 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family LOH1CR12 PF10158.4 ESA13702.1 - 0.17 11.7 2.9 0.2 11.4 2.0 1.2 1 0 0 1 1 1 0 Tumour suppressor protein Seryl_tRNA_N PF02403.17 ESA13702.1 - 0.17 11.9 14.4 0.66 10.0 8.2 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.7 ESA13702.1 - 0.18 12.0 2.8 0.62 10.3 1.8 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein APG6 PF04111.7 ESA13702.1 - 0.2 10.6 14.4 0.22 10.5 10.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 ESA13702.1 - 0.28 10.7 14.4 0.53 9.8 10.0 1.6 1 1 0 1 1 1 0 IncA protein TBPIP PF07106.8 ESA13702.1 - 0.32 10.5 13.8 0.48 9.9 9.6 1.4 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF724 PF05266.9 ESA13702.1 - 0.33 10.5 13.8 0.2 11.2 4.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF2408 PF10303.4 ESA13702.1 - 0.36 10.9 6.3 0.41 10.7 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Syntaxin_2 PF14523.1 ESA13702.1 - 0.37 10.8 8.3 0.3 11.1 2.9 2.0 1 1 1 2 2 2 0 Syntaxin-like protein DivIVA PF05103.8 ESA13702.1 - 0.44 10.6 11.3 1.3 9.0 1.8 2.2 1 1 1 2 2 2 0 DivIVA protein SlyX PF04102.7 ESA13702.1 - 0.61 10.4 7.3 1.2 9.6 2.6 2.3 1 1 1 2 2 2 0 SlyX Spc7 PF08317.6 ESA13702.1 - 0.69 8.5 16.1 2 6.9 11.1 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein H-kinase_dim PF02895.9 ESA13702.1 - 0.69 10.2 3.5 4.6 7.6 1.6 2.5 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Transposase_22 PF02994.9 ESA13702.1 - 0.74 8.2 13.5 0.78 8.1 9.4 1.1 1 0 0 1 1 1 0 L1 transposable element DUF4164 PF13747.1 ESA13702.1 - 1.1 9.4 7.8 1.6 8.8 4.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Ax_dynein_light PF10211.4 ESA13702.1 - 1.1 8.9 14.0 0.35 10.6 5.9 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain TMF_DNA_bd PF12329.3 ESA13702.1 - 1.3 8.8 24.0 7.8 6.3 10.6 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.7 ESA13702.1 - 1.4 8.7 7.4 1.3 8.8 4.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF848 PF05852.6 ESA13702.1 - 1.7 8.5 9.8 2.4 7.9 6.8 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) V_ATPase_I PF01496.14 ESA13702.1 - 1.8 6.3 10.2 2.1 6.0 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.10 ESA13702.1 - 2.2 7.7 13.3 2.3 7.7 3.9 2.5 1 1 1 2 2 2 0 Septum formation initiator Atg14 PF10186.4 ESA13702.1 - 2.3 7.0 10.1 2.9 6.7 7.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF972 PF06156.8 ESA13702.1 - 2.4 8.5 11.0 5.3 7.4 7.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) zf-C4H2 PF10146.4 ESA13702.1 - 2.7 7.9 14.5 3.3 7.6 10.1 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF342 PF03961.8 ESA13702.1 - 4.6 5.5 14.0 4.8 5.4 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Snapin_Pallidin PF14712.1 ESA13702.1 - 6.2 7.2 9.7 3.5 8.0 1.8 2.2 1 1 1 2 2 2 0 Snapin/Pallidin ATG16 PF08614.6 ESA13703.1 - 0.00028 20.7 14.2 0.00031 20.6 9.8 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) FliJ PF02050.11 ESA13703.1 - 0.00044 20.2 10.3 0.00058 19.9 7.1 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein Nsp1_C PF05064.8 ESA13703.1 - 0.0031 17.1 5.9 0.037 13.6 4.1 2.4 1 1 0 1 1 1 1 Nsp1-like C-terminal region NOSIC PF08060.8 ESA13703.1 - 0.0034 17.1 2.6 4 7.3 0.1 3.3 1 1 2 3 3 3 0 NOSIC (NUC001) domain IncA PF04156.9 ESA13703.1 - 0.0041 16.7 17.1 0.0054 16.3 11.8 1.1 1 0 0 1 1 1 1 IncA protein Tektin PF03148.9 ESA13703.1 - 0.0046 15.5 8.6 0.0058 15.2 6.0 1.3 1 0 0 1 1 1 1 Tektin family APG6 PF04111.7 ESA13703.1 - 0.0053 15.8 14.8 0.0062 15.6 10.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg6 Myosin_tail_1 PF01576.14 ESA13703.1 - 0.0066 14.2 13.1 0.0073 14.1 9.0 1.0 1 0 0 1 1 1 1 Myosin tail CHASE3 PF05227.8 ESA13703.1 - 0.0076 15.9 8.0 0.011 15.3 5.5 1.3 1 1 0 1 1 1 1 CHASE3 domain Seryl_tRNA_N PF02403.17 ESA13703.1 - 0.012 15.6 9.1 0.023 14.7 6.3 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Bacillus_HBL PF05791.6 ESA13703.1 - 0.014 14.7 3.9 0.019 14.3 2.7 1.4 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF2786 PF10979.3 ESA13703.1 - 0.014 15.0 1.2 3.2 7.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2786) MscS_porin PF12795.2 ESA13703.1 - 0.014 14.6 17.6 0.023 14.0 12.2 1.4 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain gpW PF02831.10 ESA13703.1 - 0.015 14.8 0.8 5.3 6.6 0.1 2.6 1 1 2 3 3 3 0 gpW DUF2353 PF09789.4 ESA13703.1 - 0.016 14.5 9.9 0.31 10.2 6.9 2.4 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) ECM11 PF15463.1 ESA13703.1 - 0.019 15.2 3.3 0.019 15.2 2.3 2.1 1 1 1 2 2 2 0 Extracellular mutant protein 11 Tropomyosin PF00261.15 ESA13703.1 - 0.022 13.8 15.5 0.024 13.7 10.8 1.0 1 0 0 1 1 1 0 Tropomyosin PilO PF04350.8 ESA13703.1 - 0.024 14.5 0.6 0.49 10.2 0.1 2.1 1 1 1 2 2 2 0 Pilus assembly protein, PilO DUF948 PF06103.6 ESA13703.1 - 0.025 14.4 5.7 0.04 13.7 1.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Suppressor_APC PF11414.3 ESA13703.1 - 0.033 13.9 7.1 0.2 11.4 2.6 2.3 1 1 1 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein DUF1904 PF08921.6 ESA13703.1 - 0.034 14.1 1.1 0.47 10.5 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1904) DUF327 PF03885.8 ESA13703.1 - 0.036 13.8 5.2 0.05 13.4 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF327) GLE1 PF07817.8 ESA13703.1 - 0.047 12.6 3.2 0.056 12.3 2.2 1.2 1 0 0 1 1 1 0 GLE1-like protein Vps52 PF04129.7 ESA13703.1 - 0.047 12.2 2.5 0.051 12.1 1.7 1.0 1 0 0 1 1 1 0 Vps52 / Sac2 family APG17 PF04108.7 ESA13703.1 - 0.059 12.1 7.4 0.068 11.9 5.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 MCC-bdg_PDZ PF10506.4 ESA13703.1 - 0.059 13.1 9.3 0.12 12.2 2.7 2.7 1 1 1 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF3552 PF12072.3 ESA13703.1 - 0.067 12.4 16.8 0.077 12.2 11.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Tropomyosin_1 PF12718.2 ESA13703.1 - 0.07 12.9 17.4 0.077 12.8 12.1 1.1 1 0 0 1 1 1 0 Tropomyosin like Olfactory_mark PF06554.7 ESA13703.1 - 0.071 12.6 1.1 6.7 6.2 0.0 2.7 1 1 2 3 3 3 0 Olfactory marker protein Spc7 PF08317.6 ESA13703.1 - 0.073 11.7 12.3 0.097 11.3 8.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein FemAB PF02388.11 ESA13703.1 - 0.079 11.6 8.3 0.099 11.3 5.8 1.3 1 0 0 1 1 1 0 FemAB family Med29 PF11568.3 ESA13703.1 - 0.081 12.9 1.4 0.09 12.8 1.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 29 MtrB PF05440.7 ESA13703.1 - 0.081 12.9 0.4 0.77 9.8 0.1 1.9 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF3719 PF12516.3 ESA13703.1 - 0.088 12.3 0.1 10 5.7 0.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3719) Reo_sigmaC PF04582.7 ESA13703.1 - 0.09 11.9 1.2 0.09 11.9 0.8 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein RRF_GI PF12614.3 ESA13703.1 - 0.094 12.5 3.7 0.33 10.7 2.5 1.9 1 1 0 1 1 1 0 Ribosome recycling factor Use1 PF09753.4 ESA13703.1 - 0.095 12.1 5.9 0.19 11.1 4.1 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 AAA_27 PF13514.1 ESA13703.1 - 0.12 10.0 8.8 0.11 10.1 6.1 1.0 1 0 0 1 1 1 0 AAA domain DUF1151 PF06625.6 ESA13703.1 - 0.13 12.0 10.6 0.19 11.4 7.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1151) BBP1_C PF15272.1 ESA13703.1 - 0.13 11.8 16.6 0.59 9.6 6.0 2.2 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal YjcZ PF13990.1 ESA13703.1 - 0.13 11.3 3.1 0.14 11.3 2.2 1.0 1 0 0 1 1 1 0 YjcZ-like protein PH_3 PF14593.1 ESA13703.1 - 0.15 11.9 1.1 8.7 6.2 0.0 2.7 1 1 2 3 3 3 0 PH domain BCNT PF07572.7 ESA13703.1 - 0.18 11.7 3.0 1.5 8.7 0.2 2.3 1 1 2 3 3 3 0 Bucentaur or craniofacial development TMF_DNA_bd PF12329.3 ESA13703.1 - 0.18 11.5 16.4 0.55 10.0 3.5 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding ScpA_ScpB PF02616.9 ESA13703.1 - 0.2 11.2 5.9 0.26 10.8 4.1 1.3 1 0 0 1 1 1 0 ScpA/B protein UxaC PF02614.9 ESA13703.1 - 0.21 10.1 2.9 0.23 10.0 2.0 1.0 1 0 0 1 1 1 0 Glucuronate isomerase DUF16 PF01519.11 ESA13703.1 - 0.21 11.8 7.6 0.87 9.8 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 ALIX_LYPXL_bnd PF13949.1 ESA13703.1 - 0.22 10.4 11.3 0.25 10.2 4.0 2.0 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV Laminin_I PF06008.9 ESA13703.1 - 0.22 10.8 11.4 0.23 10.7 7.9 1.1 1 0 0 1 1 1 0 Laminin Domain I RNA_pol_Rpb2_3 PF04565.11 ESA13703.1 - 0.23 11.2 1.0 16 5.3 0.1 2.6 2 1 0 2 2 2 0 RNA polymerase Rpb2, domain 3 DUF812 PF05667.6 ESA13703.1 - 0.24 9.8 11.2 0.28 9.6 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) THEG PF14912.1 ESA13703.1 - 0.25 11.9 1.1 8.6 6.9 0.7 2.6 1 1 0 1 1 1 0 Testicular haploid expressed repeat DUF1319 PF07028.6 ESA13703.1 - 0.25 11.5 7.7 0.17 12.0 1.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) ENT PF03735.9 ESA13703.1 - 0.27 11.0 5.5 0.14 11.9 0.7 2.1 1 1 1 2 2 2 0 ENT domain DUF1664 PF07889.7 ESA13703.1 - 0.27 11.0 3.0 0.39 10.5 2.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.7 ESA13703.1 - 0.27 10.9 13.7 1.7 8.3 9.5 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF342 PF03961.8 ESA13703.1 - 0.31 9.4 12.3 0.33 9.3 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spectrin PF00435.16 ESA13703.1 - 0.31 11.3 8.5 4.8 7.5 0.8 2.2 1 1 0 1 1 1 0 Spectrin repeat NumbF PF06311.7 ESA13703.1 - 0.32 11.1 2.3 5.1 7.2 1.6 2.4 1 1 0 1 1 1 0 NUMB domain Baculo_PEP_C PF04513.7 ESA13703.1 - 0.32 10.8 6.7 0.54 10.0 4.6 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Hemagglutinin PF00509.13 ESA13703.1 - 0.35 8.9 4.4 0.27 9.3 2.5 1.3 1 1 1 2 2 2 0 Haemagglutinin AFOR_C PF01314.13 ESA13703.1 - 0.37 9.4 2.3 0.8 8.3 0.1 1.9 1 1 1 2 2 2 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 Flu_NS2 PF00601.14 ESA13703.1 - 0.38 10.9 6.3 0.27 11.4 1.1 2.0 1 1 1 2 2 2 0 Influenza non-structural protein (NS2) PspB PF06667.7 ESA13703.1 - 0.39 10.6 8.4 0.2 11.5 2.0 2.4 1 1 2 3 3 3 0 Phage shock protein B COG2 PF06148.6 ESA13703.1 - 0.39 10.5 4.0 0.81 9.5 2.8 1.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 MAD PF05557.8 ESA13703.1 - 0.39 8.7 15.0 0.4 8.7 10.4 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein AAA_13 PF13166.1 ESA13703.1 - 0.4 9.0 10.9 0.43 8.9 7.6 1.1 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.5 ESA13703.1 - 0.43 10.6 9.5 0.54 10.3 6.6 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MCPsignal PF00015.16 ESA13703.1 - 0.44 10.0 5.2 0.44 10.0 3.6 1.1 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Mnd1 PF03962.10 ESA13703.1 - 0.47 10.1 13.2 2.2 7.8 9.2 1.8 1 1 0 1 1 1 0 Mnd1 family CDC37_N PF03234.9 ESA13703.1 - 0.57 10.4 6.8 0.61 10.3 4.7 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Med2 PF11214.3 ESA13703.1 - 0.61 10.1 6.8 0.76 9.8 4.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF4200 PF13863.1 ESA13703.1 - 0.62 10.0 15.7 0.74 9.7 5.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Cortex-I_coil PF09304.5 ESA13703.1 - 0.71 9.9 12.5 3.1 7.8 4.8 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil TMPIT PF07851.8 ESA13703.1 - 0.8 8.7 7.7 0.84 8.6 5.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF365 PF04033.7 ESA13703.1 - 0.86 9.6 4.6 5.5 7.0 1.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF365) FTO_CTD PF12934.2 ESA13703.1 - 0.92 9.0 7.3 2.8 7.4 4.7 1.7 1 1 1 2 2 2 0 FTO C-terminal domain HemX PF04375.9 ESA13703.1 - 0.98 7.9 5.7 1.1 7.7 3.9 1.2 1 0 0 1 1 1 0 HemX Prefoldin_2 PF01920.15 ESA13703.1 - 1 9.1 16.4 0.43 10.3 5.0 2.2 1 1 1 2 2 2 0 Prefoldin subunit DUF4404 PF14357.1 ESA13703.1 - 1.1 9.7 10.8 0.53 10.7 3.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Tweety PF04906.8 ESA13703.1 - 1.1 7.5 4.2 1.2 7.4 2.9 1.0 1 0 0 1 1 1 0 Tweety HAUS-augmin3 PF14932.1 ESA13703.1 - 1.2 8.3 13.6 4.5 6.3 4.3 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF745 PF05335.8 ESA13703.1 - 1.2 8.6 4.9 4.7 6.6 3.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF1366 PF07104.6 ESA13703.1 - 1.3 8.6 7.8 2.9 7.5 4.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1366) Prefoldin PF02996.12 ESA13703.1 - 1.4 8.6 11.9 1.4 8.5 1.0 2.8 1 1 2 3 3 3 0 Prefoldin subunit Med4 PF10018.4 ESA13703.1 - 1.4 8.2 9.4 1.7 7.9 6.5 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 IFT57 PF10498.4 ESA13703.1 - 1.5 7.5 12.7 1.9 7.1 8.8 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.4 ESA13703.1 - 1.6 7.5 11.9 1.7 7.5 8.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Tup_N PF08581.5 ESA13703.1 - 1.7 8.9 14.5 2.6 8.3 1.9 3.0 1 1 2 3 3 3 0 Tup N-terminal SlyX PF04102.7 ESA13703.1 - 1.7 9.0 11.5 3.9 7.9 3.1 2.1 1 1 1 2 2 2 0 SlyX XhlA PF10779.4 ESA13703.1 - 1.7 8.5 13.2 0.83 9.6 4.8 2.2 1 1 1 2 2 2 0 Haemolysin XhlA UVR PF02151.14 ESA13703.1 - 2 8.0 7.0 18 4.9 0.0 3.7 3 2 0 3 3 3 0 UvrB/uvrC motif GP41 PF00517.12 ESA13703.1 - 2.1 7.8 6.8 1.7 8.1 3.4 1.7 1 1 1 2 2 2 0 Retroviral envelope protein Glutaredoxin2_C PF04399.8 ESA13703.1 - 2.2 7.8 5.2 6.6 6.3 0.6 2.1 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain Uds1 PF15456.1 ESA13703.1 - 2.3 8.2 10.3 22 5.0 7.0 2.2 1 1 0 1 1 1 0 Up-regulated During Septation DUF2203 PF09969.4 ESA13703.1 - 2.5 8.3 7.0 5.2 7.3 4.8 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) V_ATPase_I PF01496.14 ESA13703.1 - 2.5 5.8 8.9 2.7 5.7 6.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2533 PF10752.4 ESA13703.1 - 2.5 8.4 5.7 4.4 7.6 3.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2533) TBPIP PF07106.8 ESA13703.1 - 2.5 7.6 12.0 3.4 7.2 8.3 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HSP70 PF00012.15 ESA13703.1 - 2.6 5.8 8.6 2.6 5.8 6.0 1.0 1 0 0 1 1 1 0 Hsp70 protein CENP-F_leu_zip PF10473.4 ESA13703.1 - 2.8 7.7 16.8 5.3 6.8 11.7 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Adeno_PIX PF03955.9 ESA13703.1 - 3 8.4 5.3 17 6.0 0.2 2.1 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) LMBR1 PF04791.11 ESA13703.1 - 4.2 5.8 6.0 4.2 5.8 4.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein YlqD PF11068.3 ESA13703.1 - 4.9 7.2 11.3 10 6.1 7.8 1.6 1 1 0 1 1 1 0 YlqD protein DUF4179 PF13786.1 ESA13703.1 - 5 7.4 5.4 19 5.5 0.6 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4179) DUF3450 PF11932.3 ESA13703.1 - 5.7 6.1 10.7 5.8 6.1 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF724 PF05266.9 ESA13703.1 - 5.9 6.4 9.2 6.8 6.2 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) YebO PF13974.1 ESA13703.1 - 5.9 6.7 8.7 1.2 9.0 0.6 2.3 1 1 1 2 2 2 0 YebO-like protein CENP-Q PF13094.1 ESA13703.1 - 6.5 6.7 20.2 4.6 7.2 7.0 2.1 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit FlaC_arch PF05377.6 ESA13703.1 - 6.8 6.6 10.8 17 5.3 0.3 3.0 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.1 ESA13703.1 - 7.1 7.1 9.6 2.4 8.6 1.9 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMF_TATA_bd PF12325.3 ESA13703.1 - 7.3 6.3 19.2 8.8 6.0 13.3 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Nup54 PF13874.1 ESA13703.1 - 9.3 5.9 11.6 18 5.0 8.0 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 WEMBL PF05701.6 ESA13704.1 - 0.00012 20.6 15.4 0.00012 20.6 10.7 1.7 1 1 1 2 2 2 1 Weak chloroplast movement under blue light IncA PF04156.9 ESA13704.1 - 0.0016 18.0 18.9 0.002 17.7 13.1 1.2 1 0 0 1 1 1 1 IncA protein APG6 PF04111.7 ESA13704.1 - 0.0028 16.7 17.9 0.003 16.6 12.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Fib_alpha PF08702.5 ESA13704.1 - 0.0061 16.6 12.5 0.0061 16.6 8.7 1.3 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family EzrA PF06160.7 ESA13704.1 - 0.0096 14.1 13.4 0.011 13.9 9.3 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Ada3 PF10198.4 ESA13704.1 - 0.023 14.4 4.9 0.023 14.4 3.4 2.3 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 YscO PF07321.7 ESA13704.1 - 0.065 13.0 17.2 0.082 12.7 10.4 1.8 1 1 1 2 2 2 0 Type III secretion protein YscO Cob_adeno_trans PF01923.13 ESA13704.1 - 0.067 12.9 9.0 1.4 8.6 0.2 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Tmemb_cc2 PF10267.4 ESA13704.1 - 0.1 11.1 16.0 0.25 9.9 11.1 1.6 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Reo_sigmaC PF04582.7 ESA13704.1 - 0.13 11.3 4.5 0.15 11.1 3.1 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein V_ATPase_I PF01496.14 ESA13704.1 - 0.15 9.8 11.3 0.16 9.8 7.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phlebovirus_NSM PF07246.6 ESA13704.1 - 0.17 11.0 11.5 0.037 13.1 1.4 2.1 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M Striatin PF08232.7 ESA13704.1 - 0.19 12.0 13.3 0.28 11.5 2.1 2.1 1 1 1 2 2 2 0 Striatin family Nup54 PF13874.1 ESA13704.1 - 0.23 11.1 13.0 0.47 10.1 8.8 1.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF869 PF05911.6 ESA13704.1 - 0.26 9.4 16.9 0.31 9.2 11.7 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Fez1 PF06818.10 ESA13704.1 - 0.47 10.4 15.2 1.5 8.7 10.6 1.7 1 1 0 1 1 1 0 Fez1 DUF4404 PF14357.1 ESA13704.1 - 0.68 10.3 15.5 0.73 10.2 2.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Flu_NS2 PF00601.14 ESA13704.1 - 0.77 10.0 6.3 1.3 9.3 0.8 2.2 1 1 1 2 2 2 0 Influenza non-structural protein (NS2) CASP_C PF08172.7 ESA13704.1 - 0.84 8.6 12.2 3.8 6.4 8.2 1.9 1 1 0 1 1 1 0 CASP C terminal Mnd1 PF03962.10 ESA13704.1 - 1.2 8.8 14.2 1.1 8.9 8.7 1.7 1 1 1 2 2 2 0 Mnd1 family DUF4200 PF13863.1 ESA13704.1 - 1.4 8.8 20.0 0.3 11.0 10.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF972 PF06156.8 ESA13704.1 - 1.7 9.0 15.8 0.27 11.6 3.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HrpB7 PF09486.5 ESA13704.1 - 1.7 8.5 11.3 20 5.0 7.8 2.0 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Pox_A_type_inc PF04508.7 ESA13704.1 - 1.8 8.5 0.0 1.8 8.5 0.0 4.1 5 0 0 5 5 3 0 Viral A-type inclusion protein repeat HAUS-augmin3 PF14932.1 ESA13704.1 - 1.9 7.5 17.4 2.3 7.3 12.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Atg14 PF10186.4 ESA13704.1 - 2 7.2 15.3 2.7 6.8 10.6 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 AF0941-like PF14591.1 ESA13704.1 - 2.2 8.3 11.7 3.1 7.8 8.1 1.4 1 1 0 1 1 1 0 AF0941-like DivIC PF04977.10 ESA13704.1 - 2.4 7.7 19.9 0.35 10.4 1.8 3.2 1 1 2 3 3 3 0 Septum formation initiator Spc7 PF08317.6 ESA13704.1 - 2.6 6.6 19.0 3 6.4 13.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.4 ESA13704.1 - 3.3 5.8 11.8 3.8 5.6 8.1 1.2 1 0 0 1 1 1 0 Transmembrane protein Cortex-I_coil PF09304.5 ESA13704.1 - 3.5 7.7 19.7 2.3 8.3 5.1 2.2 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF1664 PF07889.7 ESA13704.1 - 3.8 7.3 9.5 1.1 9.0 3.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Med9 PF07544.8 ESA13704.1 - 6.1 6.6 12.4 2.1 8.1 2.3 2.6 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Methyltransf_9 PF08003.6 ESA13704.1 - 7 5.2 6.3 3.5 6.2 2.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) Occludin_ELL PF07303.8 ESA13704.1 - 7 7.4 8.2 4.5 8.0 2.4 2.3 1 1 1 2 2 2 0 Occludin homology domain DUF2383 PF09537.5 ESA13705.1 - 0.00084 19.5 5.2 0.0075 16.5 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2383) DUF4455 PF14643.1 ESA13705.1 - 0.002 16.8 13.1 0.002 16.8 8.7 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4455) GAS PF13851.1 ESA13705.1 - 0.035 13.2 16.0 0.047 12.8 11.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Flagellin_C PF00700.16 ESA13705.1 - 0.041 14.0 0.9 0.083 13.0 0.6 1.6 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region DUF493 PF04359.9 ESA13705.1 - 0.11 12.9 1.1 0.17 12.2 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF493) Cep57_MT_bd PF06657.8 ESA13705.1 - 0.11 12.4 10.8 0.21 11.5 1.3 2.8 2 2 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3584 PF12128.3 ESA13705.1 - 0.11 9.7 11.5 0.12 9.7 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Striatin PF08232.7 ESA13705.1 - 0.15 12.3 13.6 7.7 6.8 9.5 2.1 1 1 0 1 1 1 0 Striatin family DUF1351 PF07083.6 ESA13705.1 - 0.19 11.3 10.4 0.23 11.0 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) HIGH_NTase1 PF05636.6 ESA13705.1 - 0.21 10.5 4.2 0.21 10.5 2.2 1.5 1 1 0 1 1 1 0 HIGH Nucleotidyl Transferase YqcI_YcgG PF08892.6 ESA13705.1 - 0.21 11.1 2.8 0.46 10.0 0.6 1.9 1 1 1 2 2 2 0 YqcI/YcgG family TMCO5 PF14992.1 ESA13705.1 - 0.24 10.5 18.2 2.4 7.1 9.0 2.2 1 1 1 2 2 2 0 TMCO5 family TPD PF14811.1 ESA13705.1 - 0.29 10.6 6.6 0.25 10.8 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function TPD sequence-motif AbiH PF14253.1 ESA13705.1 - 0.31 10.5 6.5 0.39 10.2 4.5 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH NYD-SP28_assoc PF14775.1 ESA13705.1 - 0.37 10.5 6.1 0.14 11.8 1.3 2.4 1 1 1 2 2 2 0 Sperm tail C-terminal domain DUF2408 PF10303.4 ESA13705.1 - 0.62 10.1 8.6 1.3 9.1 5.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF342 PF03961.8 ESA13705.1 - 0.64 8.3 10.3 0.71 8.2 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) HSP70 PF00012.15 ESA13705.1 - 0.8 7.5 10.1 0.95 7.2 7.0 1.0 1 0 0 1 1 1 0 Hsp70 protein OmpH PF03938.9 ESA13705.1 - 0.86 9.5 9.1 1.1 9.1 6.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vac_Fusion PF02346.11 ESA13705.1 - 0.88 9.0 6.3 2.5 7.6 0.9 2.6 2 1 0 2 2 2 0 Chordopoxvirus fusion protein Ferritin PF00210.19 ESA13705.1 - 0.95 9.2 7.5 1.9 8.2 3.6 2.2 1 1 1 2 2 2 0 Ferritin-like domain TBPIP PF07106.8 ESA13705.1 - 0.96 8.9 16.2 0.15 11.6 2.5 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BRO1 PF03097.13 ESA13705.1 - 0.99 8.0 6.5 1.3 7.6 4.2 1.4 1 1 1 2 2 2 0 BRO1-like domain TMPIT PF07851.8 ESA13705.1 - 0.99 8.4 8.1 1.1 8.2 5.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF745 PF05335.8 ESA13705.1 - 1 8.8 8.2 0.45 10.0 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Peptidase_S46 PF10459.4 ESA13705.1 - 1.3 7.2 7.2 1.4 7.2 5.0 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF2076 PF09849.4 ESA13705.1 - 1.6 8.7 5.0 22 5.0 1.5 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) TPR_MLP1_2 PF07926.7 ESA13705.1 - 1.9 8.2 17.5 5.1 6.8 12.2 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.7 ESA13705.1 - 1.9 8.7 7.3 23 5.3 1.6 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.10 ESA13705.1 - 2.2 7.8 13.1 2.3 7.7 2.8 2.7 2 1 1 3 3 3 0 Septum formation initiator IncA PF04156.9 ESA13705.1 - 2.2 7.8 16.6 4.3 6.8 11.5 1.5 1 1 0 1 1 1 0 IncA protein Fmp27_WPPW PF10359.4 ESA13705.1 - 3.1 6.0 14.4 0.4 9.0 1.9 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Fib_alpha PF08702.5 ESA13705.1 - 5.3 7.1 10.7 59 3.7 7.4 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family AKNA PF12443.3 ESA13705.1 - 6.2 6.8 7.6 4.1 7.4 1.5 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor DUF2203 PF09969.4 ESA13705.1 - 6.9 6.9 10.2 17 5.6 3.8 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Prefoldin_2 PF01920.15 ESA13705.1 - 7.9 6.3 19.8 1.5 8.6 2.3 3.0 1 1 2 3 3 3 0 Prefoldin subunit YqzL PF14006.1 ESA13705.1 - 7.9 6.7 9.0 3.2 8.0 0.2 3.1 3 0 0 3 3 3 0 YqzL-like protein DUF4200 PF13863.1 ESA13705.1 - 8.4 6.3 20.1 7.4 6.5 11.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Kinesin PF00225.18 ESA13706.1 - 9e-26 90.3 0.1 9.3e-26 90.3 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain tRNA-synt_1d PF00750.14 ESA13707.1 - 8.2e-91 304.4 7.7 1e-90 304.1 5.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 ESA13707.1 - 3.7e-23 81.7 0.1 1.7e-22 79.5 0.0 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 ESA13707.1 - 2.7e-10 40.6 0.3 1.2e-09 38.6 0.0 2.3 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain HTH_Crp_2 PF13545.1 ESA13707.1 - 0.078 12.7 0.0 0.28 10.9 0.0 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain GTP_EFTU PF00009.22 ESA13708.1 - 9.6e-65 217.5 0.4 1.4e-64 216.9 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESA13708.1 - 2.4e-35 120.7 0.0 6.2e-35 119.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 ESA13708.1 - 2.9e-20 71.9 0.0 8e-20 70.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 ESA13708.1 - 8.2e-15 54.4 0.2 2.5e-14 52.8 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 ESA13708.1 - 7.2e-13 48.4 0.0 6.8e-12 45.3 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA13708.1 - 8e-06 25.8 0.1 1.7e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESA13708.1 - 0.02 15.3 0.2 0.051 14.0 0.1 1.7 1 0 0 1 1 1 0 Miro-like protein PduV-EutP PF10662.4 ESA13708.1 - 0.074 12.5 0.6 0.49 9.8 0.3 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sec2p PF06428.6 ESA13709.1 - 0.024 14.4 1.5 0.67 9.8 0.3 2.6 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Phage_int_SAM_5 PF13102.1 ESA13709.1 - 0.043 13.8 0.4 0.16 11.9 0.3 1.9 1 0 0 1 1 1 0 Phage integrase SAM-like domain TAN PF11640.3 ESA13709.1 - 0.046 13.4 0.4 0.14 11.8 0.3 1.8 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair DAHP_synth_1 PF00793.15 ESA13710.1 - 3.8e-96 320.9 0.1 4.6e-96 320.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family LSM PF01423.17 ESA13711.1 - 9.4e-17 60.3 0.0 1.2e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESA13711.1 - 0.019 14.8 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Pkinase_Tyr PF07714.12 ESA13712.1 - 0.00071 18.7 0.0 0.001 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13712.1 - 0.023 13.8 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain CDC45 PF02724.9 ESA13712.1 - 0.06 11.3 1.9 0.079 10.9 1.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.7 ESA13712.1 - 5.5 6.1 6.0 6.9 5.8 4.2 1.1 1 0 0 1 1 1 0 SDA1 Methyltransf_33 PF10017.4 ESA13713.1 - 2.9e-27 95.0 0.3 7.1e-27 93.7 0.1 1.8 2 0 0 2 2 2 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.11 ESA13713.1 - 5.4e-23 81.6 0.7 2.3e-12 46.8 0.0 2.2 2 0 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.2 ESA13713.1 - 1.2e-06 28.9 0.1 3.1e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 DinB superfamily Kelch_5 PF13854.1 ESA13714.1 - 6.4e-06 26.0 4.5 0.00044 20.1 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA13714.1 - 2.5e-05 23.8 1.0 0.87 9.4 0.0 4.2 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA13714.1 - 0.001 19.1 3.4 0.15 12.2 0.0 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA13714.1 - 0.027 14.2 0.0 0.027 14.2 0.0 4.4 4 1 0 4 4 4 0 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA13714.1 - 0.038 14.1 3.8 4.6 7.5 0.0 3.9 4 1 0 4 4 4 0 Kelch motif Trp_oprn_chp PF09534.5 ESA13714.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Kelch_5 PF13854.1 ESA13715.1 - 2.1e-16 59.4 11.7 1.2e-06 28.2 0.3 6.3 7 0 0 7 7 7 3 Kelch motif Kelch_3 PF13415.1 ESA13715.1 - 9.6e-16 57.4 4.5 0.00031 20.8 0.1 6.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA13715.1 - 4.3e-15 54.8 11.4 0.0062 16.2 0.1 7.0 6 1 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA13715.1 - 5.6e-15 54.7 22.5 0.00095 19.2 0.6 7.3 6 2 1 7 7 7 4 Kelch motif Kelch_4 PF13418.1 ESA13715.1 - 5.6e-14 51.6 22.5 5.5e-05 22.8 0.1 6.7 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA13715.1 - 1.9e-08 33.6 15.9 0.014 14.9 0.3 6.9 7 1 0 7 7 7 3 Kelch motif DUF4331 PF14224.1 ESA13715.1 - 0.024 13.8 0.1 0.13 11.4 0.0 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4331) SKG6 PF08693.5 ESA13715.1 - 0.051 12.9 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Hydantoinase_A PF01968.13 ESA13715.1 - 0.062 12.3 0.4 0.099 11.7 0.3 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase AAA_30 PF13604.1 ESA13716.1 - 6.8e-10 38.8 0.0 2.3e-09 37.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain zf-RING_2 PF13639.1 ESA13717.1 - 1.7e-15 56.5 8.3 3.8e-15 55.4 5.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA13717.1 - 2e-08 34.2 10.3 1e-07 31.9 7.1 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA13717.1 - 2e-08 34.1 8.2 5.1e-08 32.8 5.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA13717.1 - 9.8e-08 31.5 5.7 2.2e-07 30.4 4.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA13717.1 - 1.6e-07 30.8 8.1 3.3e-07 29.8 5.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA13717.1 - 9.5e-05 22.1 5.2 0.00022 21.0 3.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESA13717.1 - 0.00017 21.2 6.7 0.00037 20.1 4.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA13717.1 - 0.0025 17.5 7.7 0.0051 16.5 5.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 ESA13717.1 - 0.0028 17.4 7.4 0.011 15.6 5.1 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 ESA13717.1 - 0.0044 16.5 2.2 0.0085 15.6 1.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.1 ESA13717.1 - 0.022 14.3 5.0 0.058 12.9 3.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 ESA13717.1 - 0.34 10.9 8.1 0.79 9.8 5.6 1.6 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 ESA13717.1 - 2.6 8.0 7.2 8.2 6.4 5.0 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING-like PF08746.6 ESA13717.1 - 4.3 7.4 6.7 9.1 6.3 4.7 1.5 1 0 0 1 1 1 0 RING-like domain BNIP2 PF12496.3 ESA13720.1 - 0.097 12.8 3.0 4.1 7.5 0.5 2.2 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PPR_2 PF13041.1 ESA13721.1 - 9e-57 188.8 29.5 1.6e-12 47.1 0.2 10.6 5 3 6 11 11 11 9 PPR repeat family PPR_3 PF13812.1 ESA13721.1 - 5e-35 116.8 0.0 0.00045 20.2 0.0 9.9 10 0 0 10 10 10 7 Pentatricopeptide repeat domain PPR PF01535.15 ESA13721.1 - 1.2e-34 115.8 27.0 0.00013 21.7 0.0 11.2 11 0 0 11 11 11 9 PPR repeat PPR_1 PF12854.2 ESA13721.1 - 8.1e-25 85.9 13.9 0.002 17.5 0.0 10.3 9 1 0 9 9 9 8 PPR repeat Apc3 PF12895.2 ESA13721.1 - 0.00087 19.3 0.1 0.0061 16.6 0.1 2.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF849 PF05853.7 ESA13721.1 - 0.023 13.6 0.1 2.5 6.8 0.0 3.6 2 1 1 3 3 3 0 Prokaryotic protein of unknown function (DUF849) Alpha_kinase PF02816.13 ESA13722.1 - 2.7e-37 128.3 1.3 4.5e-37 127.5 0.9 1.4 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA13722.1 - 3.9e-07 30.3 0.0 5.5e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA13722.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Ytp1 PF10355.4 ESA13723.1 - 2.8e-62 210.3 6.9 3.5e-62 210.0 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) Cytochrom_B_N PF00033.14 ESA13723.1 - 0.079 12.3 6.5 0.24 10.7 1.1 2.9 2 2 1 3 3 3 0 Cytochrome b(N-terminal)/b6/petB DUF869 PF05911.6 ESA13724.1 - 1.1e-05 23.9 4.1 1.3e-05 23.7 2.8 1.0 1 0 0 1 1 1 1 Plant protein of unknown function (DUF869) MscS_porin PF12795.2 ESA13724.1 - 0.00031 20.1 20.4 0.00053 19.3 14.2 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain IncA PF04156.9 ESA13724.1 - 0.00079 19.0 15.4 0.0013 18.4 10.7 1.3 1 0 0 1 1 1 1 IncA protein Macoilin PF09726.4 ESA13724.1 - 0.0011 17.3 4.9 0.0014 16.9 3.4 1.2 1 0 0 1 1 1 1 Transmembrane protein Myosin_tail_1 PF01576.14 ESA13724.1 - 0.002 15.9 20.0 0.0029 15.4 13.9 1.2 1 0 0 1 1 1 1 Myosin tail WEMBL PF05701.6 ESA13724.1 - 0.0055 15.2 16.4 0.0077 14.7 11.3 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF4200 PF13863.1 ESA13724.1 - 0.0081 16.1 10.7 0.0081 16.1 7.4 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4200) PuR_N PF09182.5 ESA13724.1 - 0.013 15.0 0.1 0.029 13.9 0.1 1.5 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal DUF4404 PF14357.1 ESA13724.1 - 0.021 15.2 8.7 0.021 15.2 6.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Tropomyosin PF00261.15 ESA13724.1 - 0.025 13.7 21.4 0.043 12.8 14.8 1.3 1 0 0 1 1 1 0 Tropomyosin Sec34 PF04136.10 ESA13724.1 - 0.026 14.2 8.3 0.057 13.1 5.4 1.7 2 0 0 2 2 2 0 Sec34-like family Reo_sigmaC PF04582.7 ESA13724.1 - 0.073 12.2 1.6 0.096 11.8 1.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.6 ESA13724.1 - 0.12 11.7 11.7 0.29 10.4 1.9 2.5 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF4559 PF15112.1 ESA13724.1 - 0.16 11.1 13.0 0.23 10.6 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) 4HB_MCP_1 PF12729.2 ESA13724.1 - 0.22 10.8 13.4 0.17 11.2 6.9 2.1 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction Rogdi_lz PF10259.4 ESA13724.1 - 0.25 10.4 7.0 0.18 10.9 3.6 1.6 1 1 1 2 2 2 0 Rogdi leucine zipper containing protein Fib_alpha PF08702.5 ESA13724.1 - 0.73 9.9 14.4 0.24 11.5 5.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PspA_IM30 PF04012.7 ESA13724.1 - 0.79 9.0 19.8 18 4.5 13.7 2.2 1 1 0 1 1 1 0 PspA/IM30 family Viral_P18 PF04521.8 ESA13724.1 - 1 8.8 9.3 0.19 11.1 3.1 2.1 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein TMCO5 PF14992.1 ESA13724.1 - 1.2 8.1 16.5 2.7 7.0 11.5 1.6 1 1 0 1 1 1 0 TMCO5 family DUF3416 PF11896.3 ESA13724.1 - 1.3 8.8 5.8 1.9 8.3 3.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) DUF2664 PF10867.3 ESA13724.1 - 1.5 9.5 11.1 0.11 13.1 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2664) DUF3300 PF11737.3 ESA13724.1 - 1.6 7.9 4.1 1.3 8.2 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3300) Tho2 PF11262.3 ESA13724.1 - 1.7 7.6 14.5 0.052 12.5 1.4 2.1 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 CENP-F_leu_zip PF10473.4 ESA13724.1 - 3.2 7.5 24.2 12 5.7 16.9 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.7 ESA13724.1 - 4.2 7.1 12.9 5.7 6.7 4.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TBPIP PF07106.8 ESA13724.1 - 5.1 6.6 20.7 11 5.5 0.6 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF948 PF06103.6 ESA13724.1 - 5.1 7.0 7.9 3.9 7.3 2.1 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) EMP24_GP25L PF01105.19 ESA13724.1 - 6.3 6.4 7.7 0.93 9.1 1.9 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD CALCOCO1 PF07888.6 ESA13724.1 - 8.3 4.5 19.0 12 4.0 13.2 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF745 PF05335.8 ESA13724.1 - 8.5 5.8 18.2 0.24 10.8 8.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Spc7 PF08317.6 ESA13724.1 - 9.4 4.7 22.1 2.1 6.9 9.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2203 PF09969.4 ESA13724.1 - 9.7 6.4 12.4 12 6.1 4.2 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) TMCO5 PF14992.1 ESA13725.1 - 0.0001 21.5 12.5 0.00011 21.4 8.6 1.0 1 0 0 1 1 1 1 TMCO5 family TBPIP PF07106.8 ESA13725.1 - 0.00012 21.6 13.4 0.0042 16.6 3.1 2.0 1 1 1 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_TATA_bd PF12325.3 ESA13725.1 - 0.00016 21.3 14.3 0.01 15.5 6.5 2.8 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding APG6 PF04111.7 ESA13725.1 - 0.0003 19.9 11.3 0.00032 19.8 7.8 1.0 1 0 0 1 1 1 1 Autophagy protein Apg6 Tropomyosin_1 PF12718.2 ESA13725.1 - 0.00041 20.2 16.1 0.0026 17.6 7.0 2.8 2 1 0 2 2 2 1 Tropomyosin like GAS PF13851.1 ESA13725.1 - 0.0017 17.6 13.4 0.004 16.3 9.3 1.5 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Med10 PF09748.4 ESA13725.1 - 0.0082 15.9 1.8 0.1 12.3 0.2 2.2 1 1 1 2 2 2 1 Transcription factor subunit Med10 of Mediator complex Troponin PF00992.15 ESA13725.1 - 0.012 15.6 5.4 0.02 14.9 3.8 1.4 1 1 0 1 1 1 0 Troponin IncA PF04156.9 ESA13725.1 - 0.014 15.0 14.3 0.032 13.8 9.9 1.6 1 1 0 1 1 1 0 IncA protein DUF904 PF06005.7 ESA13725.1 - 0.017 15.4 20.1 0.14 12.4 9.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF904) NPV_P10 PF05531.7 ESA13725.1 - 0.021 15.0 3.3 0.71 10.1 0.5 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fmp27_WPPW PF10359.4 ESA13725.1 - 0.029 12.8 6.4 0.035 12.5 4.4 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Reo_sigmaC PF04582.7 ESA13725.1 - 0.031 13.4 3.2 0.035 13.2 2.2 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CP12 PF02672.10 ESA13725.1 - 0.038 14.4 2.0 4.1 7.9 0.3 2.1 2 0 0 2 2 2 0 CP12 domain CALCOCO1 PF07888.6 ESA13725.1 - 0.038 12.2 7.3 0.044 12.0 5.1 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Cep57_MT_bd PF06657.8 ESA13725.1 - 0.039 13.9 13.3 0.14 12.0 3.0 3.2 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 AAA_13 PF13166.1 ESA13725.1 - 0.042 12.3 10.0 0.045 12.2 6.9 1.1 1 0 0 1 1 1 0 AAA domain FlxA PF14282.1 ESA13725.1 - 0.045 13.6 16.1 0.1 12.5 3.2 3.0 1 1 2 3 3 3 0 FlxA-like protein Spectrin PF00435.16 ESA13725.1 - 0.049 13.9 7.1 0.035 14.3 3.1 1.8 1 1 1 2 2 2 0 Spectrin repeat TMF_DNA_bd PF12329.3 ESA13725.1 - 0.062 13.1 23.0 1.4 8.8 4.4 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding ERM PF00769.14 ESA13725.1 - 0.068 12.7 9.9 0.14 11.6 6.8 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family BLOC1_2 PF10046.4 ESA13725.1 - 0.068 13.3 11.3 0.29 11.2 2.9 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4140 PF13600.1 ESA13725.1 - 0.07 13.5 8.6 0.11 13.0 1.3 3.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2935 PF11155.3 ESA13725.1 - 0.071 13.2 3.4 0.62 10.1 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) CENP-F_leu_zip PF10473.4 ESA13725.1 - 0.091 12.6 16.3 1.5 8.6 11.3 2.2 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin PF00261.15 ESA13725.1 - 0.11 11.5 12.5 0.27 10.2 8.6 1.5 1 1 0 1 1 1 0 Tropomyosin DUF1192 PF06698.6 ESA13725.1 - 0.12 12.2 6.5 0.99 9.2 0.9 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) DUF1664 PF07889.7 ESA13725.1 - 0.12 12.1 5.9 1.4 8.7 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LUC7 PF03194.10 ESA13725.1 - 0.13 11.7 6.1 0.15 11.5 4.2 1.2 1 0 0 1 1 1 0 LUC7 N_terminus WD40_alt PF14077.1 ESA13725.1 - 0.13 11.8 4.8 3.7 7.2 0.0 2.9 2 1 1 3 3 3 0 Alternative WD40 repeat motif DUF2968 PF11180.3 ESA13725.1 - 0.14 11.5 3.1 0.19 11.0 2.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) bZIP_1 PF00170.16 ESA13725.1 - 0.14 12.1 17.2 0.2 11.6 3.2 3.2 3 0 0 3 3 3 0 bZIP transcription factor DUF3450 PF11932.3 ESA13725.1 - 0.14 11.4 5.0 0.21 10.8 3.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Cep57_CLD PF14073.1 ESA13725.1 - 0.15 11.9 9.9 0.091 12.5 4.6 2.0 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Vps53_N PF04100.7 ESA13725.1 - 0.15 10.7 7.5 1.3 7.6 2.3 2.0 1 1 1 2 2 2 0 Vps53-like, N-terminal DUF4164 PF13747.1 ESA13725.1 - 0.16 12.1 6.7 3 8.0 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Jnk-SapK_ap_N PF09744.4 ESA13725.1 - 0.17 11.9 8.8 1.5 8.7 1.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ADIP PF11559.3 ESA13725.1 - 0.19 11.6 12.3 0.065 13.1 4.7 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding YlqD PF11068.3 ESA13725.1 - 0.21 11.6 8.8 0.17 11.8 3.1 2.4 1 1 1 2 2 2 0 YlqD protein DivIC PF04977.10 ESA13725.1 - 0.22 11.0 14.4 1.2 8.6 0.4 2.9 1 1 1 3 3 3 0 Septum formation initiator Macoilin PF09726.4 ESA13725.1 - 0.24 9.6 9.1 0.27 9.4 6.3 1.1 1 0 0 1 1 1 0 Transmembrane protein FTA4 PF13093.1 ESA13725.1 - 0.25 10.7 6.3 0.34 10.2 4.4 1.3 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Med15_fungi PF05397.7 ESA13725.1 - 0.27 11.2 2.6 0.9 9.5 0.7 2.2 1 1 1 2 2 2 0 Mediator complex subunit 15 HR1 PF02185.11 ESA13725.1 - 0.3 10.8 20.6 5 6.9 2.6 3.3 1 1 2 3 3 3 0 Hr1 repeat Med9 PF07544.8 ESA13725.1 - 0.31 10.7 9.2 0.29 10.9 0.8 2.7 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.5 ESA13725.1 - 0.34 11.0 8.0 0.62 10.1 5.5 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1515 PF07439.6 ESA13725.1 - 0.34 10.7 1.9 0.77 9.5 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) LETM1 PF07766.8 ESA13725.1 - 0.35 9.8 2.5 0.41 9.6 1.8 1.1 1 0 0 1 1 1 0 LETM1-like protein TSC22 PF01166.13 ESA13725.1 - 0.39 10.6 15.8 0.27 11.2 1.4 3.7 3 1 1 4 4 4 0 TSC-22/dip/bun family Transposase_22 PF02994.9 ESA13725.1 - 0.49 8.8 7.2 0.75 8.2 5.0 1.4 1 1 0 1 1 1 0 L1 transposable element Prothymosin PF03247.9 ESA13725.1 - 0.53 10.4 7.5 0.49 10.5 4.6 1.4 1 1 0 1 1 1 0 Prothymosin/parathymosin family Seryl_tRNA_N PF02403.17 ESA13725.1 - 0.54 10.2 14.8 0.81 9.7 6.7 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF342 PF03961.8 ESA13725.1 - 0.6 8.4 9.6 0.7 8.2 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 ESA13725.1 - 0.62 7.8 6.6 0.66 7.7 4.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.7 ESA13725.1 - 0.64 9.7 9.3 7.9 6.2 6.4 2.1 1 1 0 1 1 1 0 Laminin Domain II FlaC_arch PF05377.6 ESA13725.1 - 0.65 9.9 11.9 17 5.4 0.1 3.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2203 PF09969.4 ESA13725.1 - 0.78 9.9 2.8 1.2 9.3 2.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Mnd1 PF03962.10 ESA13725.1 - 0.82 9.3 10.0 5.3 6.6 6.9 2.2 1 1 0 1 1 1 0 Mnd1 family RE_Alw26IDE PF09665.5 ESA13725.1 - 1 7.9 5.1 1.1 7.8 3.6 1.0 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) HAUS-augmin3 PF14932.1 ESA13725.1 - 1.1 8.3 10.0 1.7 7.7 7.0 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Lebercilin PF15619.1 ESA13725.1 - 1.2 8.4 14.0 3.9 6.8 7.9 2.5 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF724 PF05266.9 ESA13725.1 - 1.5 8.4 10.9 0.82 9.2 4.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Spc7 PF08317.6 ESA13725.1 - 1.5 7.4 12.4 2.2 6.8 8.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.6 ESA13725.1 - 1.8 9.0 8.3 5.2 7.5 1.8 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DASH_Dad3 PF08656.5 ESA13725.1 - 1.9 8.2 11.2 2.4 7.8 0.9 3.0 1 1 2 3 3 3 0 DASH complex subunit Dad3 DUF4472 PF14739.1 ESA13725.1 - 2 8.9 11.5 8.3 6.9 0.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Sds3 PF08598.6 ESA13725.1 - 2.1 7.8 10.1 4.8 6.6 3.3 2.7 1 1 1 2 2 2 0 Sds3-like V-SNARE PF05008.10 ESA13725.1 - 2.1 8.5 11.2 1.8 8.7 1.5 3.2 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF972 PF06156.8 ESA13725.1 - 2.2 8.6 12.0 5.6 7.3 4.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF1136 PF06582.7 ESA13725.1 - 2.2 8.0 7.3 10 5.9 1.0 3.4 3 0 0 3 3 2 0 Repeat of unknown function (DUF1136) Snapin_Pallidin PF14712.1 ESA13725.1 - 2.2 8.6 8.3 10 6.5 3.5 2.7 1 1 1 2 2 2 0 Snapin/Pallidin DUF4404 PF14357.1 ESA13725.1 - 2.3 8.7 8.7 2.3 8.6 3.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Fzo_mitofusin PF04799.8 ESA13725.1 - 2.6 7.3 10.0 12 5.2 4.0 2.7 1 1 1 2 2 2 0 fzo-like conserved region rRNA_proc-arch PF13234.1 ESA13725.1 - 2.7 7.0 9.3 3.1 6.8 0.8 2.3 1 1 2 3 3 3 0 rRNA-processing arch domain Lzipper-MIP1 PF14389.1 ESA13725.1 - 3.1 7.9 16.5 6.4 6.9 0.3 3.8 2 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Ax_dynein_light PF10211.4 ESA13725.1 - 3.4 7.4 11.3 8.1 6.2 4.4 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain Striatin PF08232.7 ESA13725.1 - 3.4 7.9 9.4 17 5.7 6.1 2.2 1 1 0 1 1 1 0 Striatin family zf-C4H2 PF10146.4 ESA13725.1 - 3.9 7.4 7.1 5.7 6.8 4.9 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein DUF4200 PF13863.1 ESA13725.1 - 4.4 7.2 14.4 53 3.7 10.0 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Uds1 PF15456.1 ESA13725.1 - 4.4 7.3 9.5 18 5.3 4.8 2.8 1 1 1 2 2 2 0 Up-regulated During Septation Syntaxin PF00804.20 ESA13725.1 - 5.2 7.2 10.8 10 6.3 7.2 1.9 1 1 0 1 1 1 0 Syntaxin Nsp1_C PF05064.8 ESA13725.1 - 5.4 6.6 9.4 7.3 6.2 3.5 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF2312 PF10073.4 ESA13725.1 - 5.7 6.3 8.5 18 4.7 1.7 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) Tnp_P_element PF12017.3 ESA13725.1 - 6.5 5.9 8.2 14 4.8 1.5 2.7 1 1 2 3 3 3 0 Transposase protein Wbp11 PF09429.5 ESA13725.1 - 7 6.7 12.1 1.5 8.8 3.5 2.6 1 1 2 3 3 3 0 WW domain binding protein 11 Kinesin-relat_1 PF12711.2 ESA13725.1 - 7.1 7.1 13.8 0.66 10.4 3.0 2.8 1 1 2 3 3 3 0 Kinesin motor DUF603 PF04645.7 ESA13725.1 - 7.9 6.3 11.2 4 7.3 1.8 2.4 1 1 2 3 3 3 0 Protein of unknown function, DUF603 Shugoshin_N PF07558.6 ESA13725.1 - 9.9 5.9 11.5 0.88 9.3 0.7 3.3 4 0 0 4 4 3 0 Shugoshin N-terminal coiled-coil region ABC_tran_2 PF12848.2 ESA13726.1 - 0.001 18.8 7.4 0.0025 17.5 4.9 1.9 1 1 0 1 1 1 1 ABC transporter TMF_DNA_bd PF12329.3 ESA13726.1 - 0.0013 18.5 9.7 0.0013 18.5 6.7 2.8 2 1 1 3 3 3 1 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.5 ESA13726.1 - 0.0074 16.4 12.0 0.0095 16.0 8.3 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family FliD_C PF07195.7 ESA13726.1 - 0.011 15.0 6.7 0.016 14.4 4.6 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus H-kinase_dim PF02895.9 ESA13726.1 - 0.014 15.7 2.2 0.023 15.0 1.5 1.6 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF3418 PF11898.3 ESA13726.1 - 0.014 13.7 2.3 0.014 13.8 0.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3418) BLOC1_2 PF10046.4 ESA13726.1 - 0.018 15.1 10.3 0.094 12.8 7.1 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.1 ESA13726.1 - 0.026 13.7 15.5 0.037 13.2 10.8 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Macoilin PF09726.4 ESA13726.1 - 0.033 12.4 6.2 0.035 12.4 4.3 1.1 1 0 0 1 1 1 0 Transmembrane protein AAA_13 PF13166.1 ESA13726.1 - 0.035 12.5 9.8 0.04 12.3 6.8 1.2 1 0 0 1 1 1 0 AAA domain bZIP_1 PF00170.16 ESA13726.1 - 0.047 13.6 2.9 0.047 13.6 2.0 3.0 2 1 0 2 2 1 0 bZIP transcription factor Tropomyosin_1 PF12718.2 ESA13726.1 - 0.047 13.5 18.5 0.059 13.2 12.9 1.3 1 0 0 1 1 1 0 Tropomyosin like DUF1664 PF07889.7 ESA13726.1 - 0.048 13.4 5.8 0.46 10.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RE_TdeIII PF09520.5 ESA13726.1 - 0.077 12.2 4.8 0.088 12.0 3.4 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII ADIP PF11559.3 ESA13726.1 - 0.081 12.8 12.0 0.11 12.3 8.2 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Reo_sigmaC PF04582.7 ESA13726.1 - 0.095 11.8 0.2 0.097 11.8 0.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF724 PF05266.9 ESA13726.1 - 0.11 12.1 11.5 0.14 11.8 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.6 ESA13726.1 - 0.22 10.1 14.2 0.26 9.9 9.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PspA_IM30 PF04012.7 ESA13726.1 - 0.26 10.5 10.6 0.32 10.3 2.5 2.1 1 1 1 2 2 2 0 PspA/IM30 family Troponin PF00992.15 ESA13726.1 - 0.27 11.3 9.0 0.38 10.8 6.3 1.3 1 1 0 1 1 1 0 Troponin Snapin_Pallidin PF14712.1 ESA13726.1 - 0.27 11.5 9.5 0.099 12.9 4.8 1.6 1 1 1 2 2 2 0 Snapin/Pallidin Cast PF10174.4 ESA13726.1 - 0.27 9.2 17.1 0.3 9.0 11.8 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone TcdB_N PF12918.2 ESA13726.1 - 0.29 11.2 10.5 0.21 11.7 3.3 2.4 2 1 0 2 2 2 0 TcdB toxin N-terminal helical domain ATG16 PF08614.6 ESA13726.1 - 0.32 10.7 17.0 0.27 11.0 5.0 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) RNA_pol_Rpb1_5 PF04998.12 ESA13726.1 - 0.37 9.9 3.5 0.45 9.7 2.4 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF4047 PF13256.1 ESA13726.1 - 0.38 10.7 6.0 0.065 13.1 0.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) NPV_P10 PF05531.7 ESA13726.1 - 0.38 11.0 4.4 1.8 8.8 2.6 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Retrotrans_gag PF03732.12 ESA13726.1 - 0.41 10.7 4.5 1.7 8.7 1.5 2.1 1 1 1 2 2 2 0 Retrotransposon gag protein Laminin_II PF06009.7 ESA13726.1 - 0.46 10.2 6.1 0.86 9.3 4.3 1.6 1 1 0 1 1 1 0 Laminin Domain II Phage_GPO PF05929.6 ESA13726.1 - 0.48 9.6 7.5 0.68 9.1 4.3 1.6 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Spc24 PF08286.6 ESA13726.1 - 0.51 10.0 15.2 0.9 9.2 4.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CENP-Q PF13094.1 ESA13726.1 - 0.62 10.0 17.8 0.62 10.0 5.1 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CobN-Mg_chel PF02514.11 ESA13726.1 - 0.62 7.3 6.0 0.65 7.3 4.1 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase Tropomyosin PF00261.15 ESA13726.1 - 0.72 8.8 18.2 1.5 7.8 10.0 1.8 1 1 0 1 1 1 0 Tropomyosin Atg14 PF10186.4 ESA13726.1 - 0.86 8.4 10.7 0.82 8.5 6.7 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mgr1 PF08602.5 ESA13726.1 - 0.9 8.4 8.1 1 8.2 5.6 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit CASP_C PF08172.7 ESA13726.1 - 0.91 8.4 9.8 0.19 10.7 2.0 2.1 2 0 0 2 2 2 0 CASP C terminal Seryl_tRNA_N PF02403.17 ESA13726.1 - 1.6 8.8 11.9 5.9 6.9 6.8 2.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF2730 PF10805.3 ESA13726.1 - 1.7 8.4 8.9 1.9 8.2 1.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Mitofilin PF09731.4 ESA13726.1 - 1.9 7.0 12.2 1.9 7.0 8.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CtIP_N PF10482.4 ESA13726.1 - 1.9 8.2 12.2 2.4 7.9 8.2 1.4 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Tup_N PF08581.5 ESA13726.1 - 2.3 8.4 17.7 2e+02 2.2 12.3 2.9 1 1 0 1 1 1 0 Tup N-terminal DUF3373 PF11853.3 ESA13726.1 - 2.3 6.6 4.8 3.1 6.2 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Nup54 PF13874.1 ESA13726.1 - 2.9 7.5 11.7 3.5 7.2 5.3 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TMPIT PF07851.8 ESA13726.1 - 3 6.8 8.1 3.4 6.6 5.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein FlgM PF04316.8 ESA13726.1 - 3.1 7.8 4.9 3.3 7.7 0.2 2.3 2 1 0 2 2 2 0 Anti-sigma-28 factor, FlgM DUF342 PF03961.8 ESA13726.1 - 3.4 5.9 11.3 4.1 5.6 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SlyX PF04102.7 ESA13726.1 - 3.9 7.9 14.8 2.1 8.7 5.2 3.1 1 1 1 2 2 2 0 SlyX APG6 PF04111.7 ESA13726.1 - 5 6.0 17.4 5.6 5.9 12.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Syntaxin-6_N PF09177.6 ESA13726.1 - 5.8 7.3 8.5 20 5.6 5.9 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF641 PF04859.7 ESA13726.1 - 6 6.6 10.9 5.6 6.7 5.2 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) IncA PF04156.9 ESA13726.1 - 6.6 6.2 20.9 24 4.4 14.5 1.8 1 1 0 1 1 1 0 IncA protein FadA PF09403.5 ESA13726.1 - 7 6.6 12.9 2.2 8.2 2.7 2.2 1 1 0 2 2 2 0 Adhesion protein FadA Prefoldin_2 PF01920.15 ESA13726.1 - 7.6 6.3 19.9 4.9 6.9 3.2 2.8 1 1 2 3 3 3 0 Prefoldin subunit Adeno_PIX PF03955.9 ESA13726.1 - 8.3 6.9 5.9 8.7 6.9 1.1 2.4 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) TBPIP PF07106.8 ESA13726.1 - 8.5 5.8 16.8 3.4 7.2 5.0 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF16 PF01519.11 ESA13726.1 - 9 6.5 12.6 67 3.7 8.7 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF3782 PF12644.2 ESA13726.1 - 9.1 6.1 8.8 1.4e+02 2.3 5.7 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) Kinesin PF00225.18 ESA13727.1 - 8.9e-107 356.6 9.3 4.8e-106 354.2 6.5 1.8 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA13727.1 - 4.1e-05 22.6 0.5 0.0052 15.7 0.1 2.2 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.1 ESA13730.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Imm47 PF15586.1 ESA13731.1 - 0.064 13.0 0.3 0.16 11.8 0.1 1.7 2 0 0 2 2 2 0 Immunity protein 47 Topoisom_I_N PF02919.10 ESA13731.1 - 0.27 10.4 2.1 0.32 10.2 1.4 1.3 1 1 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF1235 PF06822.7 ESA13734.1 - 0.0054 15.7 0.9 0.0088 15.0 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1235) Tet_JBP PF12851.2 ESA13734.1 - 0.024 13.9 0.1 0.035 13.3 0.1 1.4 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily Anthrax-tox_M PF09156.5 ESA13734.1 - 0.42 9.6 6.5 0.065 12.3 1.0 1.8 2 0 0 2 2 2 0 Anthrax toxin lethal factor, middle domain Methyltransf_33 PF10017.4 ESA13735.1 - 4.9e-31 107.2 0.2 7.4e-31 106.6 0.1 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent GIDA PF01134.17 ESA13735.1 - 0.13 11.0 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A DEK_C PF08766.6 ESA13736.1 - 0.081 12.7 0.0 0.24 11.2 0.0 1.8 1 0 0 1 1 1 0 DEK C terminal domain DUF1660 PF07874.6 ESA13737.1 - 0.00044 20.4 4.6 0.025 14.8 0.5 2.5 2 0 0 2 2 2 2 Prophage protein (DUF1660) DUF953 PF06110.6 ESA13737.1 - 0.017 14.5 0.0 0.017 14.5 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) DUF4379 PF14311.1 ESA13737.1 - 0.063 13.0 10.5 0.053 13.3 2.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) DUF2726 PF10881.3 ESA13737.1 - 0.092 12.3 0.0 0.36 10.4 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2726) DUF2228 PF10228.4 ESA13738.1 - 0.089 12.3 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Alkyl_sulf_C PF14864.1 ESA13738.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Pkinase_Tyr PF07714.12 ESA13739.1 - 8.7e-36 123.3 0.0 2.4e-35 121.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13739.1 - 1.6e-32 112.7 0.1 3.8e-32 111.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA13739.1 - 0.044 13.5 0.1 0.075 12.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4379 PF14311.1 ESA13740.1 - 0.0045 16.7 12.2 0.24 11.2 0.8 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4379) DUF953 PF06110.6 ESA13740.1 - 0.047 13.1 0.3 0.047 13.1 0.2 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_7 PF13899.1 ESA13740.1 - 0.63 10.0 3.0 14 5.8 0.0 3.0 3 0 0 3 3 3 0 Thioredoxin-like OPT PF03169.10 ESA13743.1 - 0.0068 14.9 0.0 0.0069 14.8 0.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Polysacc_synt_3 PF13440.1 ESA13743.1 - 0.038 13.4 0.0 0.042 13.2 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Pkinase_Tyr PF07714.12 ESA13746.1 - 1.3e-37 129.3 0.0 1.8e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13746.1 - 6e-37 127.1 0.7 1e-36 126.4 0.5 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA13746.1 - 3.8e-07 30.5 0.0 3.4e-05 24.3 0.0 3.0 3 0 0 3 3 3 1 Sel1 repeat APH PF01636.18 ESA13746.1 - 0.017 14.8 0.1 0.029 14.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA13746.1 - 0.023 13.7 0.2 0.046 12.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HMG_box PF00505.14 ESA13747.1 - 2.9e-07 30.6 0.6 8.7e-07 29.1 0.4 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA13747.1 - 0.00059 20.1 0.1 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 HMG-box domain DUF1510 PF07423.6 ESA13748.1 - 0.0093 15.3 0.1 0.011 15.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1510) E1_DerP2_DerF2 PF02221.10 ESA13749.1 - 1.4e-09 38.2 0.1 1.7e-06 28.3 0.0 2.0 2 0 0 2 2 2 2 ML domain Carb_bind PF10645.4 ESA13749.1 - 0.062 13.1 1.4 13 5.6 0.1 3.1 3 0 0 3 3 3 0 Carbohydrate binding DUF333 PF03891.10 ESA13749.1 - 0.099 12.4 0.0 0.26 11.1 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF333) Kelch_3 PF13415.1 ESA13752.1 - 4.4e-22 77.6 1.5 3.5e-05 23.8 0.2 5.5 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA13752.1 - 8.7e-17 60.6 19.6 0.00038 20.1 0.4 6.5 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA13752.1 - 3.2e-13 49.3 15.1 0.0067 16.3 0.5 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESA13752.1 - 2e-11 43.5 17.8 0.065 13.4 0.1 6.4 3 2 3 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESA13752.1 - 2.2e-09 36.7 6.4 0.16 11.8 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA13752.1 - 1.8e-07 30.6 16.6 0.0065 15.9 0.2 5.3 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.1 ESA13753.1 - 2.2e-07 30.6 0.1 0.039 13.9 0.0 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESA13753.1 - 1.3e-06 28.0 7.6 0.061 13.1 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA13753.1 - 2.1e-05 24.5 2.2 0.69 10.1 0.0 4.2 4 1 1 5 5 5 2 Kelch motif Plasmodium_Vir PF05795.6 ESA13753.1 - 0.00017 20.9 4.3 0.00017 20.9 3.0 1.5 2 0 0 2 2 2 1 Plasmodium vivax Vir protein Kelch_2 PF07646.10 ESA13753.1 - 0.0003 20.4 0.0 0.2 11.5 0.0 3.4 2 1 1 3 3 3 1 Kelch motif Kelch_3 PF13415.1 ESA13753.1 - 0.0022 18.1 3.2 7.2 6.9 0.0 4.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA13753.1 - 0.022 14.2 0.3 0.15 11.6 0.0 2.5 2 0 0 2 2 2 0 Kelch motif Peptidase_M14 PF00246.19 ESA13753.1 - 0.095 12.2 5.5 0.16 11.5 3.8 1.3 1 0 0 1 1 1 0 Zinc carboxypeptidase DUF2681 PF10883.3 ESA13755.1 - 0.048 13.8 2.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ubiquitin PF00240.18 ESA13756.1 - 0.00013 21.2 0.1 0.00035 19.9 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin family GPI-anchored PF10342.4 ESA13757.1 - 0.036 14.5 0.6 0.38 11.2 0.4 2.5 1 1 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Ctr PF04145.10 ESA13761.1 - 5.9e-37 126.9 8.8 6.9e-37 126.6 6.1 1.0 1 0 0 1 1 1 1 Ctr copper transporter family FUN14 PF04930.10 ESA13761.1 - 0.02 15.1 3.3 0.061 13.5 0.1 2.1 2 0 0 2 2 2 0 FUN14 family DUF3169 PF11368.3 ESA13761.1 - 2.6 7.1 10.8 0.93 8.6 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) Pkinase PF00069.20 ESA13762.1 - 1.2e-10 41.0 0.1 1.4e-10 40.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA13762.1 - 1.7e-10 40.5 0.1 4.8e-10 39.1 0.0 1.7 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.9 ESA13762.1 - 6.8e-10 38.3 0.0 9.3e-10 37.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA13762.1 - 3.9e-08 33.3 0.0 0.00043 20.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA13762.1 - 1.8e-07 30.5 0.1 2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.15 ESA13762.1 - 4e-05 22.9 0.2 5.7e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase WaaY PF06176.6 ESA13762.1 - 0.00038 19.7 0.2 0.00047 19.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.15 ESA13762.1 - 0.0063 16.1 0.1 0.012 15.1 0.1 1.7 1 1 0 1 1 1 1 Choline/ethanolamine kinase HTH_24 PF13412.1 ESA13762.1 - 0.017 14.5 0.0 0.88 9.0 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF1679 PF07914.6 ESA13762.1 - 0.02 13.5 0.1 0.026 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF4296 PF14129.1 ESA13762.1 - 0.12 12.5 1.4 0.21 11.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Hamartin PF04388.7 ESA13763.1 - 0.0039 15.9 2.6 0.0045 15.7 1.8 1.1 1 0 0 1 1 1 1 Hamartin protein SR-25 PF10500.4 ESA13763.1 - 0.27 10.6 10.3 0.33 10.3 7.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EXS PF03124.9 ESA13764.1 - 1.8e-56 191.6 13.9 2.2e-56 191.4 9.6 1.1 1 0 0 1 1 1 1 EXS family PAPS_reduct PF01507.14 ESA13765.1 - 2.1e-21 76.4 0.0 1.4e-17 64.0 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family DUF2753 PF10952.3 ESA13765.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2753) Hep_59 PF07052.6 ESA13766.1 - 1.2e-15 57.6 0.8 1.2e-15 57.6 0.5 2.8 2 1 1 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 WD-3 PF09765.4 ESA13766.1 - 0.069 12.4 1.8 0.098 11.9 1.2 1.2 1 0 0 1 1 1 0 WD-repeat region NAM-associated PF14303.1 ESA13766.1 - 1.3 9.2 26.2 0.31 11.3 15.4 1.7 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain alpha-hel2 PF14456.1 ESA13766.1 - 1.4 7.5 7.2 1.1 7.9 4.2 1.4 1 1 0 1 1 1 0 Alpha-helical domain 2 Kelch_3 PF13415.1 ESA13767.1 - 2.6e-16 59.2 0.3 0.002 18.2 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA13767.1 - 1.9e-15 56.3 9.5 0.0024 17.5 0.0 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA13767.1 - 1.9e-14 53.2 13.2 0.0022 17.8 0.3 6.9 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 ESA13767.1 - 9.2e-13 47.7 12.6 0.011 15.8 0.0 6.8 5 2 1 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA13767.1 - 4.7e-08 32.4 6.1 0.12 12.1 0.0 6.3 7 0 0 7 7 7 2 Kelch motif Kelch_1 PF01344.20 ESA13767.1 - 2.4e-07 30.1 7.2 0.021 14.3 0.0 5.4 5 2 0 5 5 5 2 Kelch motif GOLD_2 PF13897.1 ESA13767.1 - 0.029 14.5 3.0 1.9 8.7 0.1 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking p450 PF00067.17 ESA13768.1 - 3.3e-17 62.1 1.0 5.5e-17 61.4 0.7 1.2 1 1 0 1 1 1 1 Cytochrome P450 IL6 PF00489.12 ESA13768.1 - 0.1 12.2 0.0 0.48 10.0 0.0 1.8 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family DUF70 PF01901.11 ESA13768.1 - 0.72 8.8 3.8 0.13 11.2 0.3 1.4 2 0 0 2 2 2 0 Protein of unknown function DUF70 HMG_box PF00505.14 ESA13769.1 - 6.5e-09 35.9 0.2 2e-08 34.3 0.1 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA13769.1 - 0.0022 18.3 1.0 0.0061 16.9 0.0 2.2 2 0 0 2 2 2 1 HMG-box domain Zip PF02535.17 ESA13769.1 - 3.1 6.7 8.3 4.1 6.3 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter dTMP_synthase PF02593.9 ESA13770.1 - 0.0021 17.4 6.5 1.6 8.0 0.1 4.3 4 0 0 4 4 4 3 Thymidylate synthase DUF1233 PF06806.7 ESA13770.1 - 0.012 15.1 13.1 7 6.2 0.1 5.9 6 0 0 6 6 6 0 Putative excisionase (DUF1233) SpoOE-like PF09388.5 ESA13770.1 - 0.062 12.8 9.2 10 5.7 0.1 5.0 5 0 0 5 5 5 0 Spo0E like sporulation regulatory protein SF3a60_bindingd PF12108.3 ESA13770.1 - 0.26 10.8 13.8 54 3.4 0.1 5.5 5 0 0 5 5 5 0 Splicing factor SF3a60 binding domain BLOC1_2 PF10046.4 ESA13770.1 - 1.1 9.4 22.4 3.5 7.8 0.1 5.5 6 0 0 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cbl_N PF02262.11 ESA13772.1 - 0.34 10.6 4.0 0.25 11.0 0.1 2.4 3 0 0 3 3 3 0 CBL proto-oncogene N-terminal domain 1 Pkinase_Tyr PF07714.12 ESA13773.1 - 4.3e-09 35.8 0.2 4.4e-09 35.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13773.1 - 6.1e-09 35.4 0.3 6.8e-09 35.2 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain KOG2701 PF09762.4 ESA13773.1 - 0.13 12.2 0.0 0.13 12.2 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) Ribosomal_L10 PF00466.15 ESA13774.1 - 4.3e-12 45.8 0.2 1e-11 44.6 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 DUF1910 PF08928.5 ESA13776.1 - 0.00099 19.1 2.6 0.0016 18.4 1.8 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1910) Tox-MPTase2 PF15638.1 ESA13776.1 - 0.018 14.5 0.7 0.022 14.2 0.5 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 2 OmpH PF03938.9 ESA13776.1 - 0.048 13.6 0.1 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MKT1_C PF12246.3 ESA13776.1 - 0.067 12.1 0.1 0.093 11.7 0.1 1.3 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication DUF4473 PF14747.1 ESA13776.1 - 0.086 13.0 0.6 0.086 13.0 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4473) 4HB_MCP_1 PF12729.2 ESA13776.1 - 0.14 11.4 5.3 0.18 11.1 3.4 1.3 1 1 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF3150 PF11348.3 ESA13776.1 - 1.2 8.2 5.0 2.7 7.0 3.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3150) DUF1033 PF06279.6 ESA13776.1 - 1.9 8.2 7.0 1.2 8.9 3.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1033) GHL6 PF14871.1 ESA13777.1 - 0.037 14.0 0.1 0.042 13.8 0.0 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 SWI-SNF_Ssr4 PF08549.5 ESA13778.1 - 2.3e-05 22.9 0.0 2.3e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1750) Pkinase_Tyr PF07714.12 ESA13781.1 - 0.062 12.3 0.0 0.064 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Imm8 PF15560.1 ESA13782.1 - 0.0032 17.1 0.2 0.012 15.3 0.0 1.9 2 1 0 2 2 2 1 Immunity protein 8 Chordopox_A20R PF05941.8 ESA13782.1 - 0.029 13.1 0.1 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A20R protein DNA_pol3_a_NII PF11490.3 ESA13783.1 - 0.02 14.4 2.1 0.026 14.1 1.4 1.2 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Rad60-SLD PF11976.3 ESA13783.1 - 0.091 12.4 0.0 0.28 10.9 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like KaiC PF06745.8 ESA13786.1 - 0.054 12.5 0.0 0.065 12.3 0.0 1.3 1 1 0 1 1 1 0 KaiC BTB PF00651.26 ESA13787.1 - 6.5e-07 29.3 0.0 9e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 BTB/POZ domain USP7_ICP0_bdg PF12436.3 ESA13790.1 - 2.9e-74 249.4 4.9 6.7e-72 241.7 0.6 2.8 1 1 2 3 3 3 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA13790.1 - 4.4e-52 176.6 9.6 8e-52 175.7 2.1 2.6 2 1 1 3 3 3 2 Ubiquitin-specific protease C-terminal Rad60-SLD PF11976.3 ESA13790.1 - 0.038 13.6 3.2 0.43 10.2 0.1 3.6 3 1 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like BTB PF00651.26 ESA13794.1 - 3.7e-16 59.0 0.9 4.1e-16 58.9 0.6 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA13794.1 - 0.017 14.2 0.5 0.02 14.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB_2 PF02214.17 ESA13794.1 - 0.058 13.5 0.3 0.082 13.1 0.2 1.3 1 0 0 1 1 1 0 BTB/POZ domain p450 PF00067.17 ESA13795.1 - 6.3e-20 71.1 0.0 2.9e-19 68.9 0.0 1.8 1 1 0 1 1 1 1 Cytochrome P450 Sel1 PF08238.7 ESA13796.1 - 2.5e-112 364.8 40.1 1.3e-11 44.7 0.4 10.0 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA13796.1 - 0.00044 20.5 10.2 3.7 8.2 0.1 7.0 9 0 0 9 9 9 2 Tetratricopeptide repeat P22_Tail-4 PF11650.3 ESA13796.1 - 0.011 15.3 4.6 0.44 10.0 0.0 3.6 2 1 2 4 4 4 0 P22 tail accessory factor MIT PF04212.13 ESA13796.1 - 0.023 14.5 31.9 2.8 7.9 2.0 8.7 8 2 0 8 8 8 0 MIT (microtubule interacting and transport) domain Msg2_C PF12373.3 ESA13796.1 - 0.049 12.8 4.1 1.5 8.1 0.0 3.3 3 0 0 3 3 3 0 Major surface glycoprotein 2 C terminal Med1 PF10744.4 ESA13797.1 - 2.8e-06 26.3 0.8 4.1e-06 25.8 0.1 1.6 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Pentapeptide_4 PF13599.1 ESA13797.1 - 0.043 13.6 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) ubiquitin PF00240.18 ESA13798.1 - 0.0039 16.5 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family AAA_14 PF13173.1 ESA13799.1 - 0.012 15.5 2.1 0.015 15.1 0.0 2.3 2 2 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESA13799.1 - 0.066 14.0 0.1 0.21 12.3 0.0 1.9 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 ESA13801.1 - 1.6e-18 67.0 0.0 2.1e-17 63.4 0.0 2.4 1 1 0 1 1 1 1 Dynamin family EF-hand_4 PF12763.2 ESA13801.1 - 7e-17 61.0 0.0 2.4e-16 59.3 0.0 2.0 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.18 ESA13801.1 - 5.3e-09 36.0 0.1 2.8e-08 33.6 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA13801.1 - 1.4e-07 31.1 0.0 3.6e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 ESA13801.1 - 9.5e-07 28.1 0.0 1.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA13801.1 - 1.1e-05 25.8 0.0 0.0017 18.8 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein EF-hand_1 PF00036.27 ESA13801.1 - 0.00032 19.8 0.0 0.0013 17.8 0.0 2.1 1 0 0 1 1 1 1 EF hand FeoB_N PF02421.13 ESA13801.1 - 0.0028 16.9 0.1 0.17 11.1 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B PduV-EutP PF10662.4 ESA13801.1 - 0.0029 17.0 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation EF-hand_6 PF13405.1 ESA13801.1 - 0.009 15.8 0.0 0.042 13.7 0.0 2.2 2 0 0 2 2 1 1 EF-hand domain AIG1 PF04548.11 ESA13801.1 - 0.0099 15.0 0.0 0.65 9.0 0.0 2.3 2 0 0 2 2 2 1 AIG1 family Thioredoxin_6 PF13848.1 ESA13801.1 - 0.011 15.5 0.3 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like domain SRPRB PF09439.5 ESA13801.1 - 0.034 13.3 0.0 0.42 9.7 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit UPF0079 PF02367.12 ESA13801.1 - 0.046 13.3 0.0 0.093 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Ras PF00071.17 ESA13801.1 - 0.053 12.9 0.2 7.1 5.9 0.0 2.3 2 0 0 2 2 2 0 Ras family Septin PF00735.13 ESA13801.1 - 0.068 12.1 0.0 0.89 8.5 0.0 2.1 1 1 0 1 1 1 0 Septin ABC_tran PF00005.22 ESA13801.1 - 0.081 13.2 0.0 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 ESA13801.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Lectin_leg-like PF03388.8 ESA13802.1 - 2e-57 194.0 0.0 2.7e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family IFT57 PF10498.4 ESA13802.1 - 0.0043 15.8 1.9 0.0063 15.2 1.3 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 ING PF12998.2 ESA13802.1 - 0.61 10.3 3.8 1.1 9.6 0.1 2.6 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding FlaC_arch PF05377.6 ESA13802.1 - 1.5 8.7 4.1 3.2 7.7 0.1 2.9 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) YjeF_N PF03853.10 ESA13803.1 - 5.3e-36 123.7 0.0 1e-35 122.8 0.0 1.5 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 ESA13803.1 - 7.8e-07 29.5 9.6 7.8e-07 29.5 6.6 2.4 2 0 0 2 2 2 1 FDF domain LSM14 PF12701.2 ESA13803.1 - 0.00019 21.1 0.7 0.0014 18.4 0.5 2.3 1 1 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.1 ESA13803.1 - 0.004 17.0 0.5 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 Ataxin 2 SM domain LSM PF01423.17 ESA13803.1 - 0.005 16.3 0.0 0.015 14.7 0.0 1.8 1 0 0 1 1 1 1 LSM domain UDPGP PF01704.13 ESA13804.1 - 1.3e-62 211.7 0.0 1.7e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Ribosomal_S24e PF01282.14 ESA13805.1 - 1.9e-36 123.6 0.3 2.9e-36 123.1 0.1 1.4 1 1 0 1 1 1 1 Ribosomal protein S24e Cas_Csm6 PF09659.5 ESA13805.1 - 0.025 13.2 0.1 0.31 9.6 0.2 1.9 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csm6) Tocopherol_cycl PF14249.1 ESA13806.1 - 5.6e-14 51.5 2.5 2.5e-11 42.8 1.7 2.7 2 1 0 2 2 2 2 Tocopherol cyclase CDH PF02611.10 ESA13810.1 - 0.043 13.0 0.0 0.043 13.0 0.0 1.1 1 0 0 1 1 1 0 CDP-diacylglycerol pyrophosphatase Dimer_Tnp_hAT PF05699.9 ESA13811.1 - 1.4e-17 63.0 0.3 2.1e-17 62.5 0.2 1.4 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2784 PF10861.3 ESA13811.1 - 0.053 13.3 0.1 0.085 12.6 0.0 1.3 1 1 0 1 1 1 0 Protein of Unknown function (DUF2784) Dimer_Tnp_hAT PF05699.9 ESA13812.1 - 8.8e-20 70.1 0.1 1.5e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA13812.1 - 0.0054 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) F-box-like PF12937.2 ESA13813.1 - 0.0013 18.4 0.1 0.0057 16.3 0.0 2.1 2 0 0 2 2 2 1 F-box-like HMG_box PF00505.14 ESA13814.1 - 1.3e-17 63.8 17.5 2.4e-09 37.3 0.5 3.9 3 1 0 3 3 3 3 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA13814.1 - 3.4e-11 43.3 18.7 0.00016 21.9 0.2 4.6 3 1 1 4 4 4 3 HMG-box domain DUF4279 PF14106.1 ESA13814.1 - 0.00076 19.3 1.0 0.0017 18.2 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4279) HMG_box_5 PF14887.1 ESA13814.1 - 0.026 14.2 0.9 0.026 14.2 0.6 3.5 4 0 0 4 4 4 0 HMG (high mobility group) box 5 ATP-synt PF00231.14 ESA13815.1 - 1.1e-68 231.7 6.3 1.3e-68 231.5 4.4 1.1 1 0 0 1 1 1 1 ATP synthase Ribosomal_L18ae PF01775.12 ESA13816.1 - 3.1e-57 191.8 0.5 3.9e-57 191.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal L18ae/LX protein domain Ribonuc_2-5A PF06479.7 ESA13817.1 - 3.3e-47 159.5 0.1 5.1e-47 158.9 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.20 ESA13817.1 - 1.6e-43 148.7 0.0 2.2e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13817.1 - 6.8e-23 81.0 0.0 7.7e-21 74.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESA13817.1 - 0.014 14.2 0.1 0.026 13.3 0.0 1.4 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Kdo PF06293.9 ESA13817.1 - 0.081 11.9 0.0 0.24 10.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cyt-b5 PF00173.23 ESA13819.1 - 1.4e-12 47.2 0.0 1.8e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Atx10homo_assoc PF09759.4 ESA13820.1 - 2.1e-36 123.7 0.8 1.6e-35 120.8 0.1 2.5 2 1 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.1 ESA13820.1 - 0.001 19.2 0.0 0.0032 17.7 0.0 1.8 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.17 ESA13820.1 - 0.0044 16.9 0.4 0.07 13.2 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.18 ESA13820.1 - 0.011 15.5 0.0 0.07 12.9 0.0 2.5 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat Glyco_transf_34 PF05637.7 ESA13821.1 - 2.7e-22 79.4 1.1 5e-21 75.2 0.7 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 ESA13821.1 - 9.2e-10 38.2 0.1 1.7e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_8 PF01501.15 ESA13821.1 - 0.0047 16.2 0.9 0.0091 15.3 0.5 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 ESA13821.1 - 0.021 14.6 1.0 0.038 13.7 0.7 1.4 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Pil1 PF13805.1 ESA13822.1 - 3.3e-34 118.2 5.0 3.9e-34 118.0 3.4 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 GvpL_GvpF PF06386.6 ESA13822.1 - 0.0031 17.1 4.8 0.036 13.6 3.4 2.1 1 1 0 1 1 1 1 Gas vesicle synthesis protein GvpL/GvpF GrpE PF01025.14 ESA13822.1 - 0.17 11.3 6.5 0.34 10.4 4.5 1.6 1 0 0 1 1 1 0 GrpE Pollen_allerg_2 PF01620.11 ESA13822.1 - 0.22 11.8 2.0 0.24 11.6 0.5 1.7 2 0 0 2 2 2 0 Ribonuclease (pollen allergen) DUF1411 PF07199.6 ESA13822.1 - 0.73 9.2 3.4 2.3 7.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) Spore_II_R PF09551.5 ESA13822.1 - 1.1 9.3 4.4 0.8 9.7 1.7 1.8 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) V_ATPase_I PF01496.14 ESA13822.1 - 4.1 5.1 7.0 3.3 5.4 0.0 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family zf-UBP PF02148.14 ESA13823.1 - 4.6e-19 68.2 9.2 5.9e-19 67.9 6.4 1.1 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Pox_A28 PF04584.9 ESA13823.1 - 0.0048 16.7 0.2 0.0058 16.5 0.1 1.3 1 0 0 1 1 1 1 Poxvirus A28 family zf-RING_3 PF14369.1 ESA13823.1 - 0.13 12.3 0.1 0.13 12.3 0.0 3.3 3 1 0 3 3 3 0 zinc-finger zf-HIT PF04438.11 ESA13823.1 - 0.31 10.7 5.6 0.73 9.5 3.9 1.6 1 0 0 1 1 1 0 HIT zinc finger C1_1 PF00130.17 ESA13823.1 - 0.59 9.9 5.8 1.7 8.4 2.2 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_4 PF07975.7 ESA13823.1 - 1.2 9.2 8.4 15 5.6 0.1 2.6 2 1 0 2 2 2 0 TFIIH C1-like domain Pkinase PF00069.20 ESA13825.1 - 1.5e-29 102.9 1.2 3.3e-29 101.8 0.9 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13825.1 - 2.1e-29 102.3 0.0 5.3e-29 101.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESA13825.1 - 0.012 15.3 0.1 0.019 14.6 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BCS1_N PF08740.6 ESA13825.1 - 0.046 13.3 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 BCS1 N terminal Nop14 PF04147.7 ESA13826.1 - 0.022 12.6 9.5 0.031 12.2 6.6 1.1 1 0 0 1 1 1 0 Nop14-like family LMBR1 PF04791.11 ESA13826.1 - 0.048 12.2 0.6 0.049 12.2 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_C12 PF01088.16 ESA13827.1 - 0.025 13.7 0.3 0.025 13.7 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 HTH_38 PF13936.1 ESA13828.1 - 2.5e-05 23.7 0.4 3e-05 23.4 0.3 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA13828.1 - 7.1e-05 22.3 0.0 7.6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_1 PF11427.3 ESA13828.1 - 0.0074 15.9 0.0 0.01 15.4 0.0 1.3 1 1 0 1 1 1 1 Tc3 transposase PAX PF00292.13 ESA13828.1 - 0.0094 15.6 0.0 0.0094 15.6 0.0 1.0 1 0 0 1 1 1 1 'Paired box' domain HTH_35 PF13693.1 ESA13828.1 - 0.033 13.9 0.0 0.036 13.8 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_29 PF13551.1 ESA13828.1 - 0.04 14.0 0.0 0.044 13.9 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn helix HTH_27 PF13463.1 ESA13828.1 - 0.057 13.7 0.0 0.064 13.5 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain DDE_3 PF13358.1 ESA13829.1 - 1.6e-06 27.9 0.4 1.6e-05 24.6 0.1 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease Propeptide_C1 PF08127.8 ESA13831.1 - 0.014 14.9 0.0 0.055 13.1 0.0 1.8 2 0 0 2 2 2 0 Peptidase family C1 propeptide TLD PF07534.11 ESA13834.1 - 1.2e-15 57.6 5.4 1.4e-15 57.5 0.6 2.5 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA13834.1 - 5.5e-15 55.3 0.0 1.1e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13834.1 - 0.0026 17.5 1.6 0.0089 15.8 1.1 1.9 1 0 0 1 1 1 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA13834.1 - 0.053 12.5 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Pga1 PF10333.4 ESA13834.1 - 0.07 12.7 3.3 0.15 11.7 0.0 2.4 2 0 0 2 2 2 0 GPI-Mannosyltransferase II co-activator RNase_H PF00075.19 ESA13836.1 - 0.0036 17.6 0.1 0.0053 17.0 0.1 1.3 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.1 ESA13836.1 - 1 9.6 5.4 0.23 11.7 0.5 2.1 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase TLD PF07534.11 ESA13838.1 - 7.6e-10 38.9 2.8 1e-09 38.4 1.9 1.2 1 0 0 1 1 1 1 TLD Inhibitor_I24 PF10465.4 ESA13838.1 - 0.0092 15.7 0.1 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 PinA peptidase inhibitor BTB PF00651.26 ESA13839.1 - 1.6e-13 50.6 1.2 1.8e-13 50.4 0.2 1.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA13839.1 - 5.7e-05 22.8 3.1 0.00057 19.6 0.4 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA13839.1 - 0.0025 17.0 0.8 0.003 16.7 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Dehyd-heme_bind PF09098.5 ESA13839.1 - 0.06 12.7 0.0 0.075 12.4 0.0 1.1 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding HCV_NS4a PF01006.15 ESA13841.1 - 0.091 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a Ceramidase_alk PF04734.8 ESA13842.1 - 5.6e-258 857.3 0.0 6.3e-258 857.1 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase Pkinase_Tyr PF07714.12 ESA13843.1 - 1.2e-36 126.1 0.0 1.7e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13843.1 - 1.4e-31 109.5 0.0 2.5e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA13843.1 - 2.2e-07 31.2 9.9 1.5e-06 28.6 0.9 3.6 3 0 0 3 3 3 1 Sel1 repeat Striatin PF08232.7 ESA13845.1 - 0.00037 20.8 5.2 0.0023 18.2 3.6 1.9 1 1 0 1 1 1 1 Striatin family BCAS2 PF05700.6 ESA13845.1 - 0.012 15.0 2.8 0.012 15.0 1.9 1.0 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF972 PF06156.8 ESA13845.1 - 0.017 15.4 3.0 0.018 15.3 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Glypican PF01153.14 ESA13845.1 - 0.04 12.5 0.7 0.044 12.3 0.5 1.0 1 0 0 1 1 1 0 Glypican Microtub_assoc PF07989.6 ESA13845.1 - 0.14 12.0 7.7 0.52 10.1 5.3 1.9 1 1 0 1 1 1 0 Microtubule associated IncA PF04156.9 ESA13845.1 - 0.19 11.2 2.9 0.2 11.2 2.0 1.0 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ESA13845.1 - 0.27 11.2 5.8 0.42 10.5 3.9 1.5 1 1 0 1 1 1 0 bZIP transcription factor CCDC-167 PF15188.1 ESA13845.1 - 0.33 10.9 3.5 0.41 10.6 2.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF904 PF06005.7 ESA13845.1 - 0.55 10.5 5.6 1 9.7 3.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF3568 PF12092.3 ESA13845.1 - 0.64 9.7 4.0 4.4 7.0 2.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3568) DWNN PF08783.6 ESA13845.1 - 1.2 9.1 4.5 5.4 7.0 0.8 2.0 1 1 1 2 2 2 0 DWNN domain bZIP_2 PF07716.10 ESA13845.1 - 1.3 8.9 6.6 7 6.5 0.3 2.0 1 1 1 2 2 2 0 Basic region leucine zipper DivIC PF04977.10 ESA13845.1 - 1.3 8.5 6.8 1.4 8.4 3.1 1.9 1 1 1 2 2 2 0 Septum formation initiator Ribosomal_S27e PF01667.12 ESA13848.1 - 0.018 14.5 2.4 3.1 7.4 0.2 2.9 3 0 0 3 3 3 0 Ribosomal protein S27 zinc_ribbon_4 PF13717.1 ESA13848.1 - 0.26 11.0 4.0 3.7 7.3 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 ESA13848.1 - 0.35 10.4 4.5 2.9 7.5 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain C1_1 PF00130.17 ESA13848.1 - 1.1 9.0 4.2 4.3 7.1 0.9 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HIT PF04438.11 ESA13848.1 - 1.8 8.2 7.2 0.54 9.9 0.1 2.5 3 0 0 3 3 3 0 HIT zinc finger WD40 PF00400.27 ESA13850.1 - 1.1e-43 145.5 12.8 8.7e-10 38.1 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA13850.1 - 7.7e-08 32.2 0.7 0.00068 19.4 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ESA13850.1 - 0.00073 17.7 0.3 0.053 11.6 0.0 2.8 1 1 2 3 3 3 1 Nucleoporin Nup120/160 PQQ_2 PF13360.1 ESA13850.1 - 0.0023 17.4 0.0 0.011 15.2 0.0 2.1 2 1 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.11 ESA13850.1 - 0.026 12.8 0.0 0.11 10.7 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Tub PF01167.13 ESA13850.1 - 0.068 12.1 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Tub family Lactamase_B PF00753.22 ESA13851.1 - 3.1e-24 85.7 0.4 4.8e-24 85.0 0.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESA13851.1 - 7.8e-07 28.8 0.2 1.2e-06 28.2 0.2 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 ESA13851.1 - 0.012 15.2 0.2 0.016 14.9 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain HARE-HTH PF05066.8 ESA13851.1 - 0.088 13.1 0.1 0.19 12.0 0.1 1.6 1 0 0 1 1 1 0 HB1, ASXL, restriction endonuclease HTH domain DUF695 PF05117.7 ESA13851.1 - 0.11 12.4 0.1 1.3 8.9 0.0 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF695) Autotrns_rpt PF12951.2 ESA13851.1 - 0.33 10.7 3.6 3.5 7.4 1.1 2.4 2 0 0 2 2 2 0 Autotransporter-associated beta strand repeat Iso_dh PF00180.15 ESA13852.1 - 7.5e-20 71.1 0.0 8.3e-20 71.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RhoGAP PF00620.22 ESA13853.1 - 2.4e-42 144.1 0.0 9.9e-42 142.1 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.24 ESA13853.1 - 1e-13 51.3 1.9 2e-13 50.4 0.1 2.6 2 0 0 2 2 2 1 PH domain PX PF00787.19 ESA13853.1 - 2.1e-11 43.5 0.0 1.6e-10 40.7 0.0 2.6 3 0 0 3 3 3 1 PX domain PH_8 PF15409.1 ESA13853.1 - 0.0027 17.7 0.2 0.015 15.3 0.0 2.4 3 0 0 3 3 3 1 Pleckstrin homology domain PH_7 PF15408.1 ESA13853.1 - 0.0076 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain TFIIB PF00382.14 ESA13854.1 - 0.0019 17.9 0.0 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 Transcription factor TFIIB repeat BRF1 PF07741.8 ESA13854.1 - 0.045 13.9 11.0 0.17 12.1 7.6 2.1 1 1 0 1 1 1 0 Brf1-like TBP-binding domain DUF1168 PF06658.7 ESA13854.1 - 0.54 9.7 11.7 1.7 8.1 8.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) CS PF04969.11 ESA13855.1 - 5.3e-10 39.7 0.0 2e-09 37.8 0.0 2.1 1 0 0 1 1 1 1 CS domain C-term_anchor PF13461.1 ESA13856.1 - 7.7e-08 32.6 8.1 2.8 8.4 0.0 6.0 5 1 0 5 5 5 1 Cell-wall surface anchor repeat DUF896 PF05979.7 ESA13856.1 - 4.3e-07 29.4 6.3 1 8.9 0.1 5.4 1 1 4 5 5 5 2 Bacterial protein of unknown function (DUF896) DUF4604 PF15377.1 ESA13856.1 - 8e-06 26.1 12.3 0.65 10.1 0.2 4.6 1 1 2 3 3 3 3 Domain of unknown function (DUF4604) MucBP PF06458.7 ESA13856.1 - 6.1e-05 23.5 10.9 4.3 7.9 2.0 5.0 1 1 4 5 5 5 2 MucBP domain Cas_Csa5 PF09702.5 ESA13856.1 - 6.3e-05 22.9 4.8 10 6.2 1.0 5.0 1 1 3 4 4 4 0 CRISPR-associated protein (Cas_Csa5) DsbC_N PF10411.4 ESA13856.1 - 0.00086 18.5 0.2 49 3.2 0.0 4.9 5 0 0 5 5 5 0 Disulfide bond isomerase protein N-terminus zf-CCHC_5 PF14787.1 ESA13856.1 - 0.001 18.4 0.1 18 4.8 0.0 4.8 5 0 0 5 5 5 0 GAG-polyprotein viral zinc-finger NosD PF05048.8 ESA13856.1 - 0.0012 18.0 1.2 0.0024 17.0 0.8 1.7 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF3319 PF11782.3 ESA13856.1 - 0.0048 16.6 0.0 4.6 7.1 0.0 3.3 1 1 4 5 5 5 1 Protein of unknown function (DUF3319) SAM_adeno_trans PF01887.11 ESA13856.1 - 0.013 14.6 0.4 10 5.0 0.0 3.2 1 1 2 3 3 3 0 S-adenosyl-l-methionine hydroxide adenosyltransferase DUF3804 PF12707.2 ESA13856.1 - 0.02 14.4 0.4 1.8 8.1 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3804) Iso_dh PF00180.15 ESA13856.1 - 0.032 13.2 0.3 0.54 9.1 0.0 2.5 1 1 1 2 2 2 0 Isocitrate/isopropylmalate dehydrogenase DUF2688 PF10892.3 ESA13856.1 - 0.039 13.6 4.0 46 3.7 0.0 4.6 5 1 1 6 6 6 0 Protein of unknown function (DUF2688) DUF3109 PF11307.3 ESA13856.1 - 0.097 12.1 2.1 0.48 9.9 0.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3109) Adeno_PIX PF03955.9 ESA13856.1 - 0.13 12.7 0.2 1.9 9.0 0.0 2.5 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) Pox_A21 PF05323.7 ESA13856.1 - 0.15 12.4 0.3 7.2 7.0 0.0 2.8 2 1 1 3 3 3 0 Poxvirus A21 Protein Pox_polyA_pol_N PF12630.2 ESA13859.1 - 0.015 15.3 0.0 0.015 15.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain DUF4561 PF15120.1 ESA13859.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4561) Cohesin_HEAT PF12765.2 ESA13859.1 - 0.12 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion RasGEF PF00617.14 ESA13860.1 - 3.1e-58 196.6 0.6 3.1e-58 196.6 0.4 3.0 3 1 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.15 ESA13860.1 - 4.4e-29 100.6 2.5 9.6e-29 99.5 0.3 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.23 ESA13860.1 - 5.3e-16 57.7 0.1 1.3e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain WW PF00397.21 ESA13860.1 - 6.1e-15 54.7 7.2 1.4e-07 31.2 0.5 3.7 3 0 0 3 3 3 2 WW domain SH3_9 PF14604.1 ESA13860.1 - 2.9e-12 45.9 0.0 6.8e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA13860.1 - 4.6e-11 42.0 0.0 1e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Histone PF00125.19 ESA13860.1 - 0.09 12.9 0.0 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Glyco_hydro_49 PF03718.8 ESA13861.1 - 0.022 12.8 0.9 0.026 12.5 0.6 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 49 SPX PF03105.14 ESA13861.1 - 0.068 12.9 4.3 0.085 12.6 3.0 1.0 1 0 0 1 1 1 0 SPX domain DUF2808 PF10989.3 ESA13862.1 - 0.06 12.9 0.1 0.081 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) F-box-like PF12937.2 ESA13863.1 - 6.6e-08 32.1 1.3 7.3e-08 32.0 0.3 1.6 2 0 0 2 2 2 1 F-box-like CENP-B_dimeris PF09026.5 ESA13863.1 - 0.1 12.8 3.6 0.067 13.4 1.2 1.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PRANC PF09372.5 ESA13863.1 - 0.21 11.5 0.2 0.21 11.5 0.1 2.7 3 0 0 3 3 3 0 PRANC domain NOA36 PF06524.7 ESA13863.1 - 0.33 10.1 3.0 0.41 9.8 2.1 1.1 1 0 0 1 1 1 0 NOA36 protein LRR_4 PF12799.2 ESA13864.1 - 1.5 8.5 9.6 0.79 9.4 0.3 4.3 4 2 0 4 4 4 0 Leucine Rich repeats (2 copies) AP_endonuc_2 PF01261.19 ESA13868.1 - 2.9e-33 114.9 0.0 3.9e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel EF-hand_3 PF09069.6 ESA13871.1 - 0.00094 19.2 0.1 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand DUF2431 PF10354.4 ESA13871.1 - 0.013 15.5 0.4 0.016 15.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) TIMELESS PF04821.9 ESA13871.1 - 0.014 14.6 1.5 0.019 14.2 1.0 1.1 1 0 0 1 1 1 0 Timeless protein PWI PF01480.12 ESA13871.1 - 0.072 13.2 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 PWI domain bZIP_2 PF07716.10 ESA13873.1 - 0.004 16.9 11.2 1.4 8.8 0.7 3.2 2 1 1 3 3 3 3 Basic region leucine zipper DivIC PF04977.10 ESA13873.1 - 0.0062 15.9 8.9 0.019 14.4 2.3 2.7 1 1 2 3 3 3 1 Septum formation initiator DUF972 PF06156.8 ESA13873.1 - 0.016 15.5 6.5 0.075 13.3 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2857 PF11198.3 ESA13873.1 - 0.041 13.4 1.5 0.054 13.0 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) ERM PF00769.14 ESA13873.1 - 0.16 11.4 5.9 0.18 11.2 4.1 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Lge1 PF11488.3 ESA13873.1 - 0.54 10.4 2.4 1.1 9.5 1.5 1.7 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 MRP-S26 PF14943.1 ESA13873.1 - 0.81 9.2 7.5 1 8.8 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 NYD-SP28_assoc PF14775.1 ESA13873.1 - 1.1 8.9 6.4 3.7 7.3 0.2 3.1 1 1 2 3 3 3 0 Sperm tail C-terminal domain TSC22 PF01166.13 ESA13873.1 - 1.4 8.9 8.9 13 5.7 0.2 3.0 1 1 2 3 3 3 0 TSC-22/dip/bun family bZIP_1 PF00170.16 ESA13873.1 - 1.5 8.8 10.3 11 6.0 1.1 3.1 1 1 2 3 3 3 0 bZIP transcription factor TMF_DNA_bd PF12329.3 ESA13873.1 - 2 8.2 11.1 12 5.8 3.9 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding IncA PF04156.9 ESA13873.1 - 2.3 7.7 8.2 5.9 6.4 1.6 1.9 1 1 1 2 2 2 0 IncA protein IFP_35_N PF07334.8 ESA13873.1 - 5.7 6.9 7.2 29 4.7 1.3 2.9 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus HALZ PF02183.13 ESA13873.1 - 7.1 6.4 8.3 14 5.4 0.4 3.1 1 1 2 3 3 3 0 Homeobox associated leucine zipper DUF1985 PF09331.6 ESA13874.1 - 0.053 13.3 1.5 0.33 10.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1985) DUF3068 PF11271.3 ESA13874.1 - 0.5 9.3 3.1 0.77 8.7 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3068) PQQ PF01011.16 ESA13875.1 - 3.6e-15 54.6 1.3 3.6e-05 23.0 0.0 4.2 3 1 1 4 4 4 3 PQQ enzyme repeat PQQ_2 PF13360.1 ESA13875.1 - 2.4e-12 46.8 0.1 3e-11 43.2 0.1 1.9 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.1 ESA13875.1 - 4e-10 39.6 0.8 0.055 13.7 0.0 4.5 4 0 0 4 4 4 3 PQQ-like domain FAD_binding_3 PF01494.14 ESA13876.1 - 1.2e-12 47.5 0.0 6.6e-09 35.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.5 ESA13876.1 - 0.064 12.0 0.0 0.24 10.1 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase Viral_helicase1 PF01443.13 ESA13879.1 - 0.013 15.0 0.6 0.034 13.6 0.4 1.7 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Acyl-CoA_dh_N PF02771.11 ESA13880.1 - 4.2e-30 104.6 0.1 7.6e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.19 ESA13880.1 - 2.2e-26 92.7 0.0 4.6e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 ESA13880.1 - 2.3e-19 68.6 0.0 4.5e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 ESA13880.1 - 2.4e-06 27.8 0.0 4.3e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.3 ESA13880.1 - 0.035 13.4 0.1 0.4 10.0 0.0 2.1 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Cript PF10235.4 ESA13881.1 - 1.7e-28 98.8 9.0 1.7e-28 98.8 6.2 1.5 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT DUF2039 PF10217.4 ESA13881.1 - 0.0023 17.8 8.2 0.0023 17.8 5.7 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) DUF1272 PF06906.6 ESA13881.1 - 0.039 13.7 9.1 0.17 11.7 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DUF2616 PF11077.3 ESA13881.1 - 0.079 12.4 5.2 0.095 12.1 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) stn_TNFRSF12A PF12191.3 ESA13881.1 - 0.11 12.4 2.4 0.19 11.7 1.7 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain zf-C3HC4_3 PF13920.1 ESA13881.1 - 0.36 10.5 16.6 14 5.4 0.7 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc-ribbons_6 PF07191.7 ESA13881.1 - 0.45 10.3 11.0 3.3 7.5 5.0 2.3 2 0 0 2 2 2 0 zinc-ribbons PHF5 PF03660.9 ESA13881.1 - 1.2 9.2 13.6 0.066 13.2 4.3 2.0 1 1 1 2 2 2 0 PHF5-like protein XPA_N PF01286.13 ESA13881.1 - 1.5 8.5 7.6 3.2 7.4 0.1 3.3 3 0 0 3 3 3 0 XPA protein N-terminal Endonuclease_7 PF02945.10 ESA13881.1 - 1.7 8.4 12.3 4.2 7.1 5.4 2.2 1 1 1 2 2 2 0 Recombination endonuclease VII Gin PF10764.4 ESA13881.1 - 3.1 7.5 16.8 4.6 7.0 4.6 3.1 2 2 0 2 2 2 0 Inhibitor of sigma-G Gin zinc_ribbon_2 PF13240.1 ESA13881.1 - 3.5 7.2 0.0 3.5 7.2 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain PLATZ PF04640.9 ESA13881.1 - 3.9 7.7 8.3 0.92 9.7 1.2 2.7 2 1 1 3 3 3 0 PLATZ transcription factor Prok-RING_1 PF14446.1 ESA13881.1 - 4 7.2 17.0 6 6.6 2.0 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 zf-ribbon_3 PF13248.1 ESA13881.1 - 7 5.9 12.4 1.9 7.8 1.1 3.4 3 1 0 3 3 3 0 zinc-ribbon domain Tnp_zf-ribbon_2 PF13842.1 ESA13881.1 - 9.1 6.7 17.7 15 6.0 0.8 2.5 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon GCD14 PF08704.5 ESA13882.1 - 2.7e-26 92.5 0.1 9.1e-26 90.8 0.0 1.7 1 1 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 ESA13882.1 - 1.3e-12 47.5 0.0 2.7e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA13882.1 - 7.3e-09 36.1 0.0 1.4e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 ESA13882.1 - 3.4e-06 26.7 0.0 5.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 ESA13882.1 - 1.9e-05 25.0 0.0 5.5e-05 23.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESA13882.1 - 2.6e-05 24.9 0.0 5.3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA13882.1 - 2.9e-05 24.0 0.0 6.3e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 ESA13882.1 - 5.6e-05 22.2 0.0 9e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_4 PF02390.12 ESA13882.1 - 0.00031 19.8 0.0 0.00065 18.8 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 ESA13882.1 - 0.00043 20.0 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA13882.1 - 0.00047 20.5 0.0 0.00088 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA13882.1 - 0.00085 18.7 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CDC45 PF02724.9 ESA13882.1 - 0.00093 17.3 5.1 0.0012 17.0 3.5 1.1 1 0 0 1 1 1 1 CDC45-like protein Methyltransf_25 PF13649.1 ESA13882.1 - 0.0011 19.2 0.0 0.002 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 ESA13882.1 - 0.0015 18.0 0.0 0.015 14.8 0.0 2.1 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Ubie_methyltran PF01209.13 ESA13882.1 - 0.0055 15.8 0.0 0.0085 15.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.15 ESA13882.1 - 0.01 14.9 0.0 0.02 13.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_32 PF13679.1 ESA13882.1 - 0.082 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Astro_capsid PF03115.9 ESA13882.1 - 0.099 10.8 2.3 0.13 10.5 1.6 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Nop14 PF04147.7 ESA13882.1 - 0.1 10.4 12.9 0.16 9.8 8.9 1.3 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.5 ESA13882.1 - 0.38 10.7 5.4 0.66 9.9 3.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.7 ESA13882.1 - 0.75 9.0 9.0 1.1 8.4 6.2 1.2 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.8 ESA13882.1 - 0.83 9.2 10.1 1.4 8.4 7.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Arrestin_N PF00339.24 ESA13883.1 - 7.5e-10 38.8 1.1 3.3e-07 30.2 0.1 3.1 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Formyl_trans_N PF00551.14 ESA13884.1 - 6.2e-30 104.0 0.2 1.2e-29 103.1 0.0 1.6 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.13 ESA13884.1 - 5.8e-10 39.1 0.1 2e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Formyl transferase, C-terminal domain Fungal_trans PF04082.13 ESA13886.1 - 0.36 9.6 4.4 0.41 9.4 3.1 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain IncA PF04156.9 ESA13886.1 - 0.55 9.8 3.8 0.61 9.6 2.6 1.1 1 0 0 1 1 1 0 IncA protein Ribosomal_L6e PF01159.14 ESA13886.1 - 1.9 8.7 5.6 4.2 7.6 3.9 1.6 1 1 0 1 1 1 0 Ribosomal protein L6e RGS PF00615.14 ESA13888.1 - 3.2e-16 59.4 0.3 4.3e-16 59.0 0.2 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain CENP-O PF09496.5 ESA13889.1 - 8.5e-23 80.4 0.3 1.3e-22 79.8 0.2 1.3 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component p450 PF00067.17 ESA13890.1 - 6.4e-39 133.7 0.0 6.8e-39 133.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SUKH-3 PF14433.1 ESA13891.1 - 0.0072 16.1 0.8 0.015 15.0 0.5 1.6 1 1 0 1 1 1 1 SUKH-3 immunity protein Arylsulfotrans PF05935.6 ESA13891.1 - 0.028 12.9 0.2 0.04 12.4 0.1 1.1 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) Beta-Casp PF10996.3 ESA13893.1 - 1.6e-28 99.1 0.0 1.8e-27 95.7 0.0 2.5 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.7 ESA13893.1 - 1.4e-14 53.6 0.0 3.5e-14 52.3 0.0 1.8 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_2 PF12706.2 ESA13893.1 - 6.8e-14 51.8 0.5 1.6e-11 44.1 0.1 2.9 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESA13893.1 - 8.5e-13 48.3 0.0 6.4e-12 45.5 0.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.1 ESA13893.1 - 0.0039 16.9 0.0 0.015 14.9 0.0 1.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Crust_neurohorm PF01147.12 ESA13893.1 - 0.04 13.2 0.1 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family Peptidase_M54 PF07998.6 ESA13893.1 - 0.047 13.4 1.2 0.082 12.6 0.2 1.8 2 0 0 2 2 2 0 Peptidase family M54 MotCF PF09158.5 ESA13893.1 - 0.11 12.1 0.0 0.11 12.1 0.0 2.5 3 0 0 3 3 3 0 Bacteriophage T4 MotA, C-terminal Proteasome PF00227.21 ESA13894.1 - 2e-59 200.0 0.2 2.5e-59 199.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA13894.1 - 2.1e-14 52.4 0.0 3.6e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature PAS_2 PF08446.6 ESA13894.1 - 0.019 15.4 0.2 0.072 13.5 0.0 1.9 2 0 0 2 2 2 0 PAS fold GatB_Yqey PF02637.13 ESA13894.1 - 0.048 13.3 0.6 0.073 12.7 0.4 1.2 1 0 0 1 1 1 0 GatB domain Vps51 PF08700.6 ESA13895.1 - 2.2e-12 46.6 3.4 2.4e-12 46.4 0.5 2.4 2 1 0 2 2 2 1 Vps51/Vps67 PH PF00169.24 ESA13895.1 - 0.00014 21.9 0.6 0.00038 20.6 0.4 1.7 1 0 0 1 1 1 1 PH domain Bromodomain PF00439.20 ESA13895.1 - 0.038 13.9 2.1 1.5 8.7 0.1 3.7 3 1 0 3 3 3 0 Bromodomain Longin PF13774.1 ESA13896.1 - 6.1e-17 60.9 0.0 1.1e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 ESA13896.1 - 1.9e-14 53.0 1.6 3.3e-14 52.2 1.1 1.4 1 0 0 1 1 1 1 Synaptobrevin Tbf5 PF06331.7 ESA13896.1 - 0.012 15.3 0.6 0.023 14.4 0.4 1.4 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 TSCPD PF12637.2 ESA13896.1 - 0.045 13.6 0.0 0.091 12.7 0.0 1.5 1 0 0 1 1 1 0 TSCPD domain TFR_dimer PF04253.10 ESA13896.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 1 0 1 1 1 0 Transferrin receptor-like dimerisation domain DUF3440 PF11922.3 ESA13897.1 - 0.054 13.0 0.4 0.15 11.6 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3440) tRNA-synt_2 PF00152.15 ESA13899.1 - 4.5e-34 117.7 0.0 5.3e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 ESA13899.1 - 0.0039 16.4 0.0 0.0055 15.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) YlbD_coat PF14071.1 ESA13899.1 - 0.059 13.4 0.0 0.088 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative coat protein CENP-O PF09496.5 ESA13901.1 - 0.043 14.0 0.2 0.31 11.3 0.0 2.3 2 1 0 2 2 2 0 Cenp-O kinetochore centromere component Pkinase_Tyr PF07714.12 ESA13903.1 - 0.0017 17.4 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13903.1 - 0.0042 16.2 0.0 0.0078 15.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA13904.1 - 3.9e-157 507.2 73.9 2.4e-10 40.6 0.3 18.1 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA13904.1 - 0.81 10.2 52.0 2.7 8.6 0.3 13.5 16 1 1 17 17 17 0 Tetratricopeptide repeat zf-BED PF02892.10 ESA13905.1 - 9.8e-07 28.4 0.6 2e-06 27.4 0.4 1.5 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.10 ESA13905.1 - 0.014 14.7 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_2 PF13465.1 ESA13905.1 - 0.054 13.8 2.8 0.13 12.5 1.9 1.7 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA13905.1 - 0.083 13.2 1.3 0.083 13.2 0.9 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA13905.1 - 0.13 12.4 1.7 4.1 7.6 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Pkinase_Tyr PF07714.12 ESA13906.1 - 4.7e-05 22.5 0.0 6.9e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13906.1 - 0.073 12.2 0.0 0.14 11.3 0.0 1.5 1 1 0 1 1 1 0 Protein kinase domain Utp12 PF04003.7 ESA13908.1 - 0.44 10.4 3.7 1.2 9.0 0.8 2.0 1 1 1 2 2 2 0 Dip2/Utp12 Family Homeobox PF00046.24 ESA13909.1 - 1.6e-16 59.6 3.1 1.9e-16 59.4 2.2 1.0 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 ESA13909.1 - 0.002 17.8 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.1 ESA13909.1 - 0.0092 15.6 0.4 0.015 14.9 0.0 1.5 2 0 0 2 2 2 1 Homeodomain-like domain zf-CCHC PF00098.18 ESA13910.1 - 0.0073 16.1 5.1 0.015 15.1 3.6 1.6 1 0 0 1 1 1 1 Zinc knuckle PTSIIB_sorb PF03830.10 ESA13910.1 - 0.027 14.3 0.1 0.049 13.4 0.1 1.4 1 0 0 1 1 1 0 PTS system sorbose subfamily IIB component Myb_DNA-bind_4 PF13837.1 ESA13911.1 - 0.0085 16.2 5.1 0.014 15.4 3.3 1.6 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain PriCT_2 PF08707.6 ESA13911.1 - 0.051 13.4 0.8 0.1 12.4 0.6 1.5 1 0 0 1 1 1 0 Primase C terminal 2 (PriCT-2) FTHFS PF01268.14 ESA13912.1 - 0.12 10.3 0.0 0.18 9.7 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase SR-25 PF10500.4 ESA13912.1 - 2.6 7.4 13.4 5.1 6.5 9.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MT-A70 PF05063.9 ESA13916.1 - 1.7e-56 190.5 0.1 3.2e-56 189.6 0.0 1.5 2 0 0 2 2 2 1 MT-A70 GHMP_kinases_N PF00288.21 ESA13917.1 - 1.2e-06 28.5 0.0 2.8e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESA13917.1 - 0.044 13.9 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 GHMP kinases C terminal tRNA-synt_2 PF00152.15 ESA13918.1 - 4.6e-116 387.2 0.1 6.1e-116 386.8 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 ESA13918.1 - 5.2e-06 26.1 0.1 0.0018 17.9 0.1 2.6 1 1 1 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_anti-codon PF01336.20 ESA13918.1 - 6e-05 22.8 0.0 0.00015 21.5 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESA13918.1 - 0.0032 16.7 0.1 0.0082 15.3 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) F-box PF00646.28 ESA13919.1 - 6.4e-05 22.5 0.1 0.00028 20.4 0.0 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 ESA13919.1 - 0.0004 20.0 0.1 0.0011 18.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like DUF2628 PF10947.3 ESA13920.1 - 0.63 9.8 6.1 0.8 9.5 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) RRM_1 PF00076.17 ESA13921.1 - 1.6e-30 104.5 0.0 1.9e-16 59.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.14 ESA13921.1 - 1.3e-27 93.6 0.2 3.6e-06 26.1 0.1 6.0 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_6 PF14259.1 ESA13921.1 - 2.1e-20 72.4 0.0 7e-10 38.7 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA13921.1 - 2.2e-17 62.6 0.0 2.5e-07 30.4 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAD_M PF08527.5 ESA13923.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain Pkinase_Tyr PF07714.12 ESA13924.1 - 2.9e-14 52.7 0.0 4.5e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13924.1 - 1.1e-09 37.8 0.1 3.4e-09 36.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA13924.1 - 4.2e-08 33.5 0.0 0.004 17.7 0.0 2.4 2 0 0 2 2 2 2 Sel1 repeat Peptidase_C6 PF00851.13 ESA13924.1 - 0.035 12.7 5.0 0.045 12.3 3.4 1.1 1 0 0 1 1 1 0 Helper component proteinase DUF262 PF03235.9 ESA13924.1 - 0.56 10.1 14.1 0.29 11.0 5.7 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF262 MIP-T3 PF10243.4 ESA13926.1 - 1.1e-10 40.6 24.9 1.1e-10 40.6 17.3 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 VIT1 PF01988.14 ESA13926.1 - 0.0037 16.7 0.0 0.0059 16.1 0.0 1.3 1 0 0 1 1 1 1 VIT family DUF912 PF06024.7 ESA13926.1 - 1.2 9.1 0.0 1.2 9.1 0.0 5.1 3 2 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Asp-B-Hydro_N PF05279.6 ESA13926.1 - 3.4 7.4 33.7 5.2 6.8 23.4 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Pkinase_Tyr PF07714.12 ESA13927.1 - 1.2e-25 90.1 0.0 1.7e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13927.1 - 1.3e-25 90.0 1.6 2.5e-25 89.1 1.1 1.5 1 1 0 1 1 1 1 Protein kinase domain zf-UBR PF02207.15 ESA13928.1 - 0.0049 16.5 1.8 0.0071 16.0 1.2 1.2 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF955 PF06114.8 ESA13928.1 - 0.009 15.7 0.1 0.011 15.4 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF955) Crust_neurohorm PF01147.12 ESA13928.1 - 0.033 13.5 2.1 0.049 12.9 1.5 1.3 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family BRCT_assoc PF12820.2 ESA13928.1 - 0.057 13.1 1.3 0.061 13.0 0.9 1.1 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT Ribosomal_S27e PF01667.12 ESA13928.1 - 0.084 12.4 0.8 0.13 11.8 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 Perilipin PF03036.11 ESA13929.1 - 0.0022 16.9 5.8 0.64 8.7 0.0 3.1 2 1 0 2 2 2 2 Perilipin family Apolipoprotein PF01442.13 ESA13929.1 - 0.031 13.7 6.1 0.51 9.8 0.0 2.9 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain PEP-utilisers_N PF05524.8 ESA13929.1 - 0.093 12.5 0.7 0.48 10.2 0.4 2.2 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal IncA PF04156.9 ESA13929.1 - 0.17 11.4 5.1 1.6 8.2 1.8 2.7 2 1 0 2 2 2 0 IncA protein Laminin_II PF06009.7 ESA13929.1 - 3.3 7.4 10.2 1.1 9.0 2.5 3.1 3 1 0 3 3 3 0 Laminin Domain II CPSase_L_D2 PF02786.12 ESA13931.1 - 0.048 12.9 0.0 0.063 12.5 0.0 1.1 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Pkinase_Tyr PF07714.12 ESA13932.1 - 0.00051 19.1 0.0 0.00085 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ino80_Iec3 PF14612.1 ESA13932.1 - 0.041 13.9 8.9 0.052 13.6 6.2 1.2 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling BACK PF07707.10 ESA13933.1 - 7.4e-12 45.0 4.2 8.3e-08 32.0 0.3 4.3 4 0 0 4 4 4 3 BTB And C-terminal Kelch TLD PF07534.11 ESA13933.1 - 5.8e-11 42.5 2.5 1.9e-10 40.9 0.5 2.2 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA13933.1 - 9e-09 35.3 0.2 1.8e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain Flavokinase PF01687.12 ESA13935.1 - 1.7e-40 137.7 0.0 2e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase EXOSC1 PF10447.4 ESA13936.1 - 1.7e-25 88.7 1.6 1.7e-25 88.7 1.1 1.7 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.1 ESA13936.1 - 7.3e-15 53.9 1.8 4.2e-14 51.5 0.2 2.5 3 0 0 3 3 3 1 Exosome complex exonuclease RRP4 N-terminal region S1 PF00575.18 ESA13936.1 - 0.084 12.9 0.4 1.1 9.4 0.3 2.3 1 1 0 1 1 1 0 S1 RNA binding domain Securin PF04856.8 ESA13937.1 - 0.078 12.6 1.5 0.089 12.4 1.1 1.3 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor TP1 PF02079.11 ESA13937.1 - 0.18 11.5 2.0 0.3 10.8 1.4 1.3 1 0 0 1 1 1 0 Nuclear transition protein 1 Ank_2 PF12796.2 ESA13938.1 - 8e-22 77.3 0.0 1.5e-13 50.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESA13938.1 - 4.7e-19 67.1 0.1 6.3e-10 38.3 0.0 3.9 3 1 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 ESA13938.1 - 7e-19 67.8 0.2 2.8e-07 30.8 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA13938.1 - 1.3e-18 66.5 0.0 7.6e-13 48.2 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA13938.1 - 4.3e-13 48.1 0.1 4.7e-07 29.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat SNF2_N PF00176.18 ESA13939.1 - 1.8e-81 273.1 0.1 2.8e-81 272.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 ESA13939.1 - 4e-16 58.8 1.1 2.7e-15 56.2 0.0 2.4 2 0 0 2 2 2 1 HIRAN domain Helicase_C PF00271.26 ESA13939.1 - 1e-11 44.5 0.0 2.3e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.1 ESA13939.1 - 9.6e-10 38.1 8.7 9.6e-10 38.1 6.0 2.1 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA13939.1 - 2.6e-07 30.5 10.7 2.6e-07 30.5 7.4 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA13939.1 - 4.4e-07 29.4 9.5 4.4e-07 29.4 6.6 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 ESA13939.1 - 9.4e-07 28.2 6.6 2.7e-06 26.7 4.6 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.20 ESA13939.1 - 1.8e-06 27.4 10.3 1.8e-06 27.4 7.1 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA13939.1 - 2.3e-06 27.1 6.7 6.7e-06 25.7 4.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 ESA13939.1 - 2.9e-06 27.2 3.8 2.9e-06 27.2 2.7 2.0 2 0 0 2 2 1 1 RING-H2 zinc finger U-box PF04564.10 ESA13939.1 - 6.6e-06 26.0 0.7 4.5e-05 23.3 0.1 2.7 3 0 0 3 3 2 1 U-box domain zf-RING_5 PF14634.1 ESA13939.1 - 0.00039 20.0 15.8 0.0013 18.4 5.7 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESA13939.1 - 0.0011 18.7 0.7 0.0011 18.7 0.5 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 ESA13939.1 - 0.0013 18.5 8.7 0.0032 17.3 6.1 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 ESA13939.1 - 0.096 12.4 3.8 0.29 10.9 2.6 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Rtf2 PF04641.7 ESA13939.1 - 0.39 9.8 16.5 0.2 10.8 2.4 2.8 3 0 0 3 3 3 0 Rtf2 RING-finger zf-RING_4 PF14570.1 ESA13939.1 - 1.5 8.5 6.6 3.8 7.1 4.6 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF566 PF04484.7 ESA13939.1 - 2.7 7.4 11.1 4.5 6.7 7.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) BTB PF00651.26 ESA13941.1 - 9.5e-15 54.5 0.1 2.2e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13941.1 - 2.5e-11 43.3 5.9 6.6e-08 32.3 0.8 4.1 3 1 1 4 4 4 2 BTB And C-terminal Kelch Histone PF00125.19 ESA13941.1 - 0.069 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Ndr PF03096.9 ESA13941.1 - 0.075 11.4 0.1 0.25 9.7 0.0 1.8 2 0 0 2 2 2 0 Ndr family Clathrin PF00637.15 ESA13941.1 - 0.11 12.1 4.6 3 7.4 0.0 3.7 3 1 1 4 4 4 0 Region in Clathrin and VPS Dehyd-heme_bind PF09098.5 ESA13941.1 - 0.11 11.9 0.0 8.9 5.7 0.0 2.2 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Pkinase_Tyr PF07714.12 ESA13944.1 - 3.1e-09 36.2 0.0 3.4e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13944.1 - 1.4e-08 34.2 0.0 1.5e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Spindle_Spc25 PF08234.7 ESA13944.1 - 0.088 12.8 0.0 0.22 11.5 0.0 1.6 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 DUF624 PF04854.9 ESA13944.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF624 RVT_1 PF00078.22 ESA13945.1 - 4.8e-15 55.5 0.0 3.1e-14 52.8 0.0 1.9 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF497 PF04365.8 ESA13945.1 - 0.064 13.1 5.2 0.53 10.2 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF497) Pkinase PF00069.20 ESA13947.1 - 1.3e-53 181.7 0.0 2.6e-53 180.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13947.1 - 3.3e-23 82.0 0.0 5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA13948.1 - 3.1e-25 88.7 0.4 1.5e-24 86.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13948.1 - 1.7e-22 79.8 1.5 4.9e-22 78.3 1.0 1.8 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA13948.1 - 0.00035 20.2 0.4 0.21 11.1 0.0 3.7 4 0 0 4 4 4 1 BCS1 N terminal Zn_Tnp_IS91 PF14319.1 ESA13948.1 - 0.0018 17.7 0.6 0.0018 17.7 0.4 2.9 3 0 0 3 3 3 1 Transposase zinc-binding domain APH PF01636.18 ESA13948.1 - 0.084 12.5 0.2 0.13 11.9 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family NMD3 PF04981.8 ESA13948.1 - 3.8 6.5 10.3 7.2 5.6 0.4 3.7 3 0 0 3 3 3 0 NMD3 family ADK_lid PF05191.9 ESA13948.1 - 5.6 6.7 14.3 0.68 9.6 2.6 3.5 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-C4pol PF14260.1 ESA13948.1 - 9.5 6.3 15.7 6.7 6.7 0.4 3.7 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta HNH_3 PF13392.1 ESA13949.1 - 2.4 7.6 4.8 0.43 10.0 0.3 2.0 2 0 0 2 2 2 0 HNH endonuclease HHH_3 PF12836.2 ESA13951.1 - 2e-06 27.6 0.0 3.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_6 PF14579.1 ESA13951.1 - 6.3e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif PsbU PF06514.6 ESA13951.1 - 0.00018 21.2 0.0 0.00031 20.5 0.0 1.3 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) HHH PF00633.18 ESA13951.1 - 0.026 14.2 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif LsmAD PF06741.8 ESA13951.1 - 0.031 14.3 0.2 0.039 14.0 0.2 1.3 1 0 0 1 1 1 0 LsmAD domain HHH_5 PF14520.1 ESA13951.1 - 0.045 13.9 0.1 0.051 13.7 0.1 1.3 1 1 0 1 1 1 0 Helix-hairpin-helix domain Ribosomal_S13 PF00416.17 ESA13951.1 - 0.082 13.3 0.0 0.098 13.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S13/S18 HHH_2 PF12826.2 ESA13951.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif EutC PF05985.6 ESA13952.1 - 0.11 11.5 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine ammonia-lyase light chain (EutC) Exo_endo_phos PF03372.18 ESA13955.1 - 0.049 13.5 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.18 ESA13956.1 - 3.4e-13 50.0 0.0 4.9e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA13956.1 - 4.2e-09 36.0 1.2 4.2e-09 36.0 0.8 2.4 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Tox-HNH-HHH PF15637.1 ESA13956.1 - 8.9 6.1 8.3 1.9 8.2 0.2 3.0 3 0 0 3 3 3 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Inhibitor_I53 PF11714.3 ESA13958.1 - 2.6 8.1 4.8 4.4 7.3 0.4 2.3 1 1 1 2 2 2 0 Thrombin inhibitor Madanin BTB PF00651.26 ESA13959.1 - 2.9e-08 33.6 0.0 3.2e-08 33.5 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain ATP-synt_DE PF00401.15 ESA13960.1 - 0.077 12.8 0.1 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain HMG_box PF00505.14 ESA13961.1 - 0.04 14.1 0.3 0.093 13.0 0.2 1.6 1 1 0 1 1 1 0 HMG (high mobility group) box BTB PF00651.26 ESA13962.1 - 2.9e-19 69.0 1.3 5.5e-19 68.2 0.9 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA13962.1 - 4e-12 46.3 3.5 7.3e-12 45.4 1.5 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA13962.1 - 3.4e-06 26.8 4.9 0.00019 21.2 0.2 4.2 2 2 2 4 4 4 1 BTB And C-terminal Kelch UBA_e1_C PF09358.5 ESA13962.1 - 1.8 8.7 7.7 7 6.8 0.1 3.2 3 1 1 4 4 4 0 Ubiquitin-activating enzyme e1 C-terminal domain Staphylcoagulse PF04022.7 ESA13963.1 - 0.11 11.8 0.5 6 6.3 0.3 2.4 2 0 0 2 2 2 0 Staphylocoagulase repeat HSP70 PF00012.15 ESA13964.1 - 2.7e-05 22.3 0.0 2.9e-05 22.2 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Gb3_synth PF04572.7 ESA13964.1 - 0.013 15.2 0.1 0.013 15.1 0.0 1.0 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region FoP_duplication PF13865.1 ESA13966.1 - 0.62 10.5 9.2 0.77 10.2 6.4 1.1 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 API5 PF05918.6 ESA13966.1 - 6.3 5.1 9.1 7 5.0 6.3 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Sel1 PF08238.7 ESA13967.1 - 9.6e-123 397.9 86.4 6.8e-12 45.6 0.6 13.9 14 0 0 14 14 14 13 Sel1 repeat TPR_7 PF13176.1 ESA13967.1 - 1.4e-07 30.7 15.1 1.8 8.5 0.0 7.1 6 2 1 7 7 7 4 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA13967.1 - 5.4e-05 23.1 1.3 20 5.2 0.0 6.5 5 3 1 7 7 7 1 Influenza Matrix protein (M1) C-terminal domain TPR_6 PF13174.1 ESA13967.1 - 0.0074 16.6 38.3 0.69 10.5 0.2 8.9 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA13967.1 - 0.11 12.1 62.2 0.68 9.6 3.2 8.5 4 3 4 8 8 8 0 TPR repeat SHNi-TPR PF10516.4 ESA13967.1 - 4.2 6.6 10.6 1e+02 2.2 0.0 6.4 8 0 0 8 8 8 0 SHNi-TPR Pkinase_Tyr PF07714.12 ESA13968.1 - 2e-56 190.9 0.0 4.3e-56 189.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13968.1 - 1.2e-49 168.8 0.1 1.5e-49 168.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA13968.1 - 0.0017 17.4 0.3 0.0031 16.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA13968.1 - 0.0027 16.7 0.0 0.049 12.5 0.0 2.3 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESA13968.1 - 0.0057 16.4 0.1 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA13968.1 - 0.0061 15.9 0.1 0.013 14.8 0.1 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL ABC1 PF03109.11 ESA13968.1 - 0.036 14.0 0.0 0.25 11.3 0.0 2.3 1 1 1 2 2 2 0 ABC1 family RIO1 PF01163.17 ESA13968.1 - 0.039 13.2 1.3 0.085 12.2 0.8 1.7 1 1 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.12 ESA13969.1 - 1e-46 159.1 0.0 1.3e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA13969.1 - 3.2e-46 157.5 0.3 4.1e-46 157.2 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA13969.1 - 0.00012 21.2 0.2 0.0002 20.4 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA13969.1 - 0.00024 20.9 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA13969.1 - 0.00026 20.0 0.0 0.0004 19.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 ESA13969.1 - 0.0017 17.6 0.1 0.0029 16.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA13969.1 - 0.003 16.9 0.5 0.0062 15.9 0.2 1.5 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA13969.1 - 0.0085 15.4 0.3 0.021 14.1 0.2 1.7 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.12 ESA13970.1 - 2.9e-24 85.5 0.0 2.2e-15 56.4 0.0 5.2 5 0 0 5 5 5 3 Protein tyrosine kinase Pkinase PF00069.20 ESA13970.1 - 3e-15 56.0 0.3 3e-15 56.0 0.2 3.8 4 0 0 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ESA13970.1 - 2.1e-10 40.4 0.4 0.052 13.1 0.0 5.2 5 0 0 5 5 5 3 BCS1 N terminal NOB1_Zn_bind PF08772.6 ESA13970.1 - 2.9e-06 27.0 22.8 0.19 11.5 0.3 5.6 5 0 0 5 5 5 4 Nin one binding (NOB1) Zn-ribbon like DUF3299 PF11736.3 ESA13970.1 - 0.029 14.2 0.0 93 2.8 0.0 4.8 6 0 0 6 6 6 0 Protein of unknown function (DUF3299) DUF4413 PF14372.1 ESA13970.1 - 0.045 13.7 20.2 0.14 12.1 0.1 5.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) zf-DBF PF07535.7 ESA13970.1 - 2.1 8.0 48.3 0.31 10.7 1.7 7.6 7 3 0 7 7 7 0 DBF zinc finger DUF1687 PF07955.6 ESA13973.1 - 0.012 15.5 2.8 1.4 8.8 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1687) FAD_binding_2 PF00890.19 ESA13975.1 - 8.6e-105 350.9 0.8 1.2e-104 350.5 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 ESA13975.1 - 4.9e-48 162.2 2.9 7.1e-48 161.7 2.0 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 ESA13975.1 - 0.048 13.5 0.0 0.14 12.0 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RNA12 PF10443.4 ESA13979.1 - 5.6e-07 28.4 0.0 0.0096 14.4 0.0 2.2 2 0 0 2 2 2 2 RNA12 protein Arch_ATPase PF01637.13 ESA13979.1 - 2.4e-05 24.1 0.2 0.00061 19.5 0.0 2.2 1 1 1 2 2 2 1 Archaeal ATPase AAA_16 PF13191.1 ESA13979.1 - 0.0025 17.8 0.0 0.0031 17.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 ESA13979.1 - 0.024 14.5 0.1 0.055 13.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESA13979.1 - 0.037 14.2 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 ESA13979.1 - 0.047 13.6 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA13979.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain Staphostatin_A PF09022.5 ESA13980.1 - 0.055 13.2 0.9 1.2 8.9 0.2 2.3 2 1 0 2 2 2 0 Staphostatin A SlyX PF04102.7 ESA13982.1 - 0.014 15.7 4.1 0.014 15.7 2.9 4.1 2 1 2 4 4 4 0 SlyX TMF_TATA_bd PF12325.3 ESA13982.1 - 0.57 9.9 41.2 0.056 13.1 11.1 3.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.6 ESA13982.1 - 1.9 8.2 47.1 57 3.4 3.4 3.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DASH_Dam1 PF08653.5 ESA13982.1 - 4.3 7.1 7.3 2.2 8.1 0.5 3.1 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF724 PF05266.9 ESA13982.1 - 5.8 6.4 41.9 0.02 14.5 10.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Abhydrolase_3 PF07859.8 ESA13983.1 - 2.9e-36 125.0 0.0 1.6e-29 103.0 0.0 2.7 3 0 0 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA13983.1 - 3e-08 32.7 0.0 4.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA13983.1 - 6.8e-05 22.6 0.0 0.00013 21.7 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Metallophos PF00149.23 ESA13983.1 - 0.024 14.0 0.9 0.46 9.8 0.2 2.4 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase Colicin_Pyocin PF01320.13 ESA13984.1 - 3.6 7.5 11.7 2.1 8.2 0.2 3.8 4 1 0 4 4 4 0 Colicin immunity protein / pyocin immunity protein Enterotoxin_a PF01375.12 ESA13985.1 - 1.1 8.5 3.9 1.3 8.2 2.7 1.2 1 0 0 1 1 1 0 Heat-labile enterotoxin alpha chain Sec62 PF03839.11 ESA13985.1 - 4.1 6.7 9.0 4.8 6.5 6.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DDE_1 PF03184.14 ESA13987.1 - 0.0033 16.6 5.0 1 8.4 0.1 3.4 1 1 2 3 3 3 2 DDE superfamily endonuclease Homeobox PF00046.24 ESA13987.1 - 0.0054 16.3 2.2 0.2 11.2 0.1 2.7 1 1 0 2 2 2 1 Homeobox domain HTH_Tnp_Tc5 PF03221.11 ESA13987.1 - 0.022 14.5 12.4 0.19 11.5 0.3 4.0 4 1 1 5 5 5 0 Tc5 transposase DNA-binding domain HTH_28 PF13518.1 ESA13987.1 - 0.2 11.7 1.3 0.5 10.4 0.0 2.4 2 1 1 3 3 3 0 Helix-turn-helix domain IBR PF01485.16 ESA13989.1 - 6.9e-10 38.6 10.5 1.3e-09 37.7 4.4 2.0 2 0 0 2 2 2 1 IBR domain Zn-ribbon_8 PF09723.5 ESA13989.1 - 0.0048 16.8 6.1 0.33 10.9 1.6 2.4 2 0 0 2 2 2 2 Zinc ribbon domain FeS PF04060.8 ESA13989.1 - 0.057 12.9 0.9 0.057 12.9 0.6 3.1 3 0 0 3 3 3 0 Putative Fe-S cluster zf-tcix PF14952.1 ESA13989.1 - 0.06 12.6 0.3 0.06 12.6 0.2 3.5 4 0 0 4 4 4 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.1 ESA13989.1 - 0.29 10.4 11.0 0.48 9.7 0.1 3.2 4 0 0 4 4 4 0 zinc-ribbon domain C1_4 PF07975.7 ESA13989.1 - 0.68 9.9 6.8 0.19 11.7 1.1 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain YhfH PF14149.1 ESA13989.1 - 2.1 8.2 8.6 3 7.7 0.8 2.8 2 0 0 2 2 2 0 YhfH-like protein zf-AN1 PF01428.11 ESA13989.1 - 3 7.7 8.1 2.2 8.2 2.5 2.5 2 1 0 2 2 2 0 AN1-like Zinc finger DNA_RNApol_7kD PF03604.8 ESA13989.1 - 3.1 7.3 7.8 10 5.6 1.8 3.1 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-HIT PF04438.11 ESA13989.1 - 4.3 7.0 8.5 13 5.5 1.2 2.6 2 0 0 2 2 2 0 HIT zinc finger zinc_ribbon_2 PF13240.1 ESA13989.1 - 5.7 6.5 8.4 1.1 8.8 0.2 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING-like PF08746.6 ESA13989.1 - 9.2 6.3 15.3 2.5e+02 1.7 0.1 3.1 2 1 0 2 2 2 0 RING-like domain DUF1877 PF08974.5 ESA13990.1 - 0.02 14.5 0.9 0.29 10.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) BTB PF00651.26 ESA13992.1 - 1.1e-18 67.2 0.5 1.9e-18 66.4 0.4 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA13992.1 - 6.1e-08 32.4 7.0 2.3e-06 27.3 0.1 4.3 4 1 0 5 5 5 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA13992.1 - 0.059 12.4 0.3 0.087 11.9 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB_2 PF02214.17 ESA13992.1 - 0.076 13.2 0.9 0.16 12.2 0.1 2.0 2 1 0 2 2 2 0 BTB/POZ domain Pkinase PF00069.20 ESA13994.1 - 9.6e-59 198.6 0.0 1.8e-58 197.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA13994.1 - 2.1e-38 131.8 0.0 2.6e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA13994.1 - 8.4e-05 21.6 0.0 0.00028 19.9 0.0 1.8 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESA13994.1 - 0.0035 17.1 1.0 0.0077 15.9 0.7 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA13994.1 - 0.03 13.6 0.1 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family APH_6_hur PF04655.9 ESA13994.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase zf-AN1 PF01428.11 ESA13995.1 - 1.8e-22 78.8 19.8 1.3e-12 47.3 4.8 2.3 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.10 ESA13995.1 - 0.026 14.7 14.2 0.13 12.4 2.0 2.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain HypA PF01155.14 ESA13995.1 - 3 7.5 8.7 5.2 6.7 2.1 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF3970 PF13113.1 ESA13996.1 - 0.081 12.6 0.1 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3970) DAD PF02109.11 ESA13997.1 - 1.3e-49 166.9 2.6 1.5e-49 166.7 1.8 1.0 1 0 0 1 1 1 1 DAD family DUF1440 PF07274.7 ESA13997.1 - 0.27 11.2 1.5 0.38 10.7 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1440) LSM PF01423.17 ESA13998.1 - 1.9e-18 65.7 0.2 2.5e-18 65.3 0.2 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L34 PF00468.12 ESA13999.1 - 3.3e-21 74.6 8.6 3.6e-21 74.5 6.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L34 Latrophilin PF02354.11 ESA14000.1 - 0.02 13.6 0.1 0.024 13.3 0.1 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region ADH_zinc_N PF00107.21 ESA14001.1 - 4.7e-36 123.2 0.2 7.3e-36 122.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA14001.1 - 1.6e-12 48.4 0.0 3.2e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA14001.1 - 6.5e-12 45.1 0.2 2.2e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain SIS_2 PF13580.1 ESA14001.1 - 0.05 13.3 0.3 0.12 12.0 0.2 1.6 1 1 0 1 1 1 0 SIS domain F-box-like PF12937.2 ESA14002.1 - 6.1e-05 22.6 7.4 0.00016 21.2 0.8 4.1 5 0 0 5 5 5 1 F-box-like F-box PF00646.28 ESA14002.1 - 0.0092 15.6 1.1 0.19 11.4 0.3 2.9 2 0 0 2 2 2 1 F-box domain IKKbetaNEMObind PF12179.3 ESA14002.1 - 0.043 13.6 0.4 0.28 11.0 0.0 2.5 2 1 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain DEAD PF00270.24 ESA14003.1 - 2e-18 66.4 0.0 3.4e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA14003.1 - 2.9e-08 33.7 0.0 4.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.12 ESA14003.1 - 0.13 11.6 0.0 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein TRF PF08558.5 ESA14006.1 - 9.4e-10 38.2 5.8 2.9e-09 36.6 3.7 1.7 1 1 0 1 1 1 1 Telomere repeat binding factor (TRF) BTB PF00651.26 ESA14007.1 - 6.7e-18 64.7 1.6 8.1e-17 61.2 0.1 2.2 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA14007.1 - 6.2e-08 32.7 0.1 9.6e-08 32.1 0.1 1.3 1 0 0 1 1 1 1 SPRY domain BK_channel_a PF03493.13 ESA14008.1 - 1.8e-20 72.7 0.2 1e-18 67.1 0.0 3.3 3 1 0 3 3 3 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.13 ESA14008.1 - 4.5e-07 29.8 0.3 0.00097 19.1 0.0 3.0 2 1 1 3 3 3 2 TrkA-N domain Securin PF04856.8 ESA14008.1 - 0.023 14.4 1.0 0.04 13.6 0.7 1.3 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor HMG_box PF00505.14 ESA14010.1 - 8e-10 38.8 6.5 1.3e-09 38.2 4.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA14010.1 - 1e-07 32.2 9.5 1.5e-07 31.6 6.6 1.3 1 0 0 1 1 1 1 HMG-box domain mRNA_stabil PF13929.1 ESA14010.1 - 0.016 14.1 1.4 0.017 14.0 1.0 1.1 1 0 0 1 1 1 0 mRNA stabilisation IMD PF08397.6 ESA14010.1 - 0.032 13.5 10.2 0.035 13.4 7.1 1.1 1 0 0 1 1 1 0 IRSp53/MIM homology domain RTX PF02382.10 ESA14010.1 - 0.083 11.1 0.7 0.098 10.8 0.5 1.0 1 0 0 1 1 1 0 RTX N-terminal domain TF_Zn_Ribbon PF08271.7 ESA14012.1 - 0.057 12.7 12.5 1.4 8.3 0.1 4.2 4 1 0 4 4 4 0 TFIIB zinc-binding DUF1244 PF06844.6 ESA14012.1 - 0.075 12.8 2.5 0.091 12.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) OrfB_Zn_ribbon PF07282.6 ESA14012.1 - 0.27 10.9 0.1 0.27 10.9 0.1 3.7 4 1 0 4 4 4 0 Putative transposase DNA-binding domain Pkinase_Tyr PF07714.12 ESA14013.1 - 1.1e-21 77.1 0.0 1.2e-21 77.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14013.1 - 4.4e-19 68.6 0.0 5.2e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain DUF1266 PF06889.6 ESA14014.1 - 0.055 13.2 0.1 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) zf-C2H2_2 PF12756.2 ESA14014.1 - 0.23 11.6 6.6 0.13 12.3 1.6 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 ESA14014.1 - 2.8 8.4 7.4 3.7 8.1 2.9 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type VCBS PF13517.1 ESA14017.1 - 0.03 14.6 0.2 0.034 14.5 0.1 1.0 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EPTP PF03736.12 ESA14018.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 EPTP domain DUF912 PF06024.7 ESA14021.1 - 0.0053 16.7 5.4 0.0058 16.6 0.7 2.2 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) 7TM_GPCR_Srw PF10324.4 ESA14021.1 - 0.0055 15.8 0.4 0.007 15.5 0.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF4064 PF13273.1 ESA14021.1 - 0.007 16.4 0.3 0.011 15.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) CD20 PF04103.10 ESA14021.1 - 0.007 16.3 5.2 0.059 13.2 3.7 1.9 1 1 0 1 1 1 1 CD20-like family TMEM154 PF15102.1 ESA14021.1 - 0.011 15.4 1.9 0.011 15.4 1.0 1.3 1 1 0 1 1 1 0 TMEM154 protein family Rifin_STEVOR PF02009.11 ESA14021.1 - 0.025 14.2 0.4 0.025 14.2 0.3 1.7 2 0 0 2 2 2 0 Rifin/stevor family DUF2208 PF09973.4 ESA14021.1 - 0.036 13.3 0.7 0.061 12.5 0.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) 7tm_1 PF00001.16 ESA14021.1 - 0.043 12.9 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4199 PF13858.1 ESA14021.1 - 0.046 13.6 0.1 0.07 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF687 PF05095.7 ESA14021.1 - 0.051 11.9 2.2 0.063 11.6 1.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF687) DUF1180 PF06679.7 ESA14021.1 - 0.055 13.3 0.1 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1356 PF07092.7 ESA14021.1 - 0.057 12.5 3.3 0.083 12.0 2.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1356) 7TM_GPCR_Srh PF10318.4 ESA14021.1 - 0.074 11.8 0.4 0.11 11.2 0.3 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh EpsG PF14897.1 ESA14021.1 - 0.087 11.7 0.7 0.12 11.2 0.5 1.3 1 1 0 1 1 1 0 EpsG family NfeD PF01957.13 ESA14021.1 - 0.11 12.6 0.1 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding YajC PF02699.10 ESA14021.1 - 0.12 12.0 0.2 0.12 12.0 0.2 1.8 2 1 0 2 2 2 0 Preprotein translocase subunit DUF4083 PF13314.1 ESA14021.1 - 0.76 9.6 7.6 0.074 12.8 1.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) HHH_3 PF12836.2 ESA14022.1 - 0.00086 19.2 0.3 0.0025 17.6 0.2 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif PsbU PF06514.6 ESA14022.1 - 0.025 14.4 0.0 0.22 11.3 0.0 2.6 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) HHH_6 PF14579.1 ESA14022.1 - 0.078 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF1454 PF07305.7 ESA14023.1 - 0.045 12.8 0.6 0.047 12.7 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) tRNA-synt_1b PF00579.20 ESA14023.1 - 0.049 12.7 1.0 0.053 12.6 0.7 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Herpes_UL6 PF01763.11 ESA14023.1 - 0.049 11.8 0.9 0.055 11.6 0.6 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Peptidase_C65 PF10275.4 ESA14023.1 - 0.054 12.8 0.2 0.062 12.6 0.1 1.1 1 0 0 1 1 1 0 Peptidase C65 Otubain TPR_20 PF14561.1 ESA14023.1 - 0.11 12.6 0.3 0.13 12.4 0.2 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1042 PF06294.6 ESA14024.1 - 0.033 13.7 0.1 0.048 13.2 0.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1042) BTB PF00651.26 ESA14026.1 - 4.8e-14 52.2 0.0 1.1e-13 51.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA14026.1 - 1.8e-13 50.6 6.2 5.2e-13 49.1 4.3 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA14026.1 - 8.4e-08 31.9 1.6 4.7e-07 29.5 0.2 2.9 4 0 0 4 4 4 1 BTB And C-terminal Kelch DUF2421 PF10334.4 ESA14026.1 - 0.13 11.8 0.2 5.6 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2421) Ion_trans PF00520.26 ESA14027.1 - 0.011 14.9 0.4 0.011 14.9 0.3 1.5 2 0 0 2 2 2 0 Ion transport protein Mob_synth_C PF06463.8 ESA14032.1 - 0.064 12.9 0.0 0.072 12.7 0.0 1.1 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Nbl1_Borealin_N PF10444.4 ESA14032.1 - 0.085 12.2 0.3 0.14 11.5 0.2 1.4 1 1 0 1 1 1 0 Nbl1 / Borealin N terminal Pkinase_Tyr PF07714.12 ESA14033.1 - 3.4e-37 127.9 0.0 5.6e-37 127.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14033.1 - 1e-33 116.6 0.0 2.1e-33 115.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Methyltransf_11 PF08241.7 ESA14034.1 - 2.2e-13 50.5 0.0 2.9e-11 43.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA14034.1 - 4.9e-10 39.3 0.0 7.8e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA14034.1 - 1.5e-09 38.1 0.0 3.1e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA14034.1 - 2.3e-09 37.0 0.1 8.1e-09 35.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA14034.1 - 3.6e-07 29.5 0.0 5.8e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA14034.1 - 2.7e-06 27.7 0.0 6.8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA14034.1 - 5.5e-06 26.9 0.0 3e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA14034.1 - 0.00012 21.5 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA14034.1 - 0.00078 19.4 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA14034.1 - 0.0041 17.1 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 ESA14034.1 - 0.0043 16.1 0.0 0.0065 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 ESA14034.1 - 0.059 12.4 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase BTB PF00651.26 ESA14035.1 - 1.8e-15 56.9 0.1 4e-15 55.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA14035.1 - 6.3e-12 45.6 2.4 6.3e-12 45.6 1.7 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA14035.1 - 0.015 15.1 1.0 0.049 13.4 0.3 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch Kelch_4 PF13418.1 ESA14036.1 - 9.6e-18 63.6 8.6 0.00085 19.0 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA14036.1 - 9.8e-16 57.3 3.7 0.0016 18.3 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA14036.1 - 6.2e-12 44.7 1.0 0.053 13.3 0.0 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA14036.1 - 2.3e-11 43.3 14.0 0.0058 16.7 0.0 6.6 6 1 1 7 7 7 3 Kelch motif Kelch_3 PF13415.1 ESA14036.1 - 1.1e-06 28.5 5.8 0.7 10.1 0.1 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA14036.1 - 0.0087 15.5 11.1 4.8 6.8 0.0 6.2 7 0 0 7 7 7 2 Kelch motif Secretin PF00263.16 ESA14036.1 - 0.01 15.2 0.0 0.12 11.7 0.0 2.3 1 1 0 1 1 1 0 Bacterial type II and III secretion system protein MatE PF01554.13 ESA14038.1 - 4.4e-56 188.9 27.3 6e-28 97.4 8.0 2.5 2 0 0 2 2 2 2 MatE Flagellin_IN PF07196.8 ESA14039.1 - 1.5 8.8 4.4 8.1 6.5 0.1 2.7 3 0 0 3 3 3 0 Flagellin hook IN motif HMG_box PF00505.14 ESA14041.1 - 0.00016 21.8 0.6 0.0032 17.7 0.3 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box COQ7 PF03232.8 ESA14041.1 - 0.33 10.3 1.5 1.6 8.2 1.1 2.1 1 1 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 HMG_box PF00505.14 ESA14042.1 - 0.00073 19.7 0.7 0.00073 19.7 0.5 2.9 4 0 0 4 4 4 1 HMG (high mobility group) box DUF3783 PF12646.2 ESA14042.1 - 1.2 8.9 5.7 1.7 8.4 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) DUF4234 PF14018.1 ESA14043.1 - 0.02 14.6 1.0 0.02 14.6 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) DUF3043 PF11241.3 ESA14043.1 - 0.052 13.1 0.1 0.094 12.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) C2 PF00168.25 ESA14044.1 - 3.3e-21 74.9 0.4 5.2e-21 74.2 0.3 1.3 1 0 0 1 1 1 1 C2 domain DUF4429 PF14472.1 ESA14044.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4429) TLD PF07534.11 ESA14045.1 - 7.7e-13 48.6 1.5 1e-11 45.0 0.2 2.6 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA14045.1 - 0.0001 22.0 3.1 0.0093 15.7 1.0 2.8 1 1 1 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.26 ESA14045.1 - 0.00034 20.5 0.5 0.0017 18.3 0.0 2.4 2 1 0 2 2 2 1 BTB/POZ domain Nucleoplasmin PF03066.10 ESA14046.1 - 0.69 9.4 5.2 0.83 9.1 3.6 1.2 1 0 0 1 1 1 0 Nucleoplasmin DUF2457 PF10446.4 ESA14046.1 - 1.8 7.2 9.7 2 7.0 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 ESA14046.1 - 5.1 7.4 9.8 7.9 6.8 6.8 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3110 PF11360.3 ESA14048.1 - 0.03 14.1 0.2 0.035 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3110) BTB_2 PF02214.17 ESA14049.1 - 2.1e-22 79.1 0.1 5.3e-22 77.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_L21e PF01157.13 ESA14051.1 - 0.012 15.4 0.3 3.2 7.6 0.0 2.9 3 1 1 4 4 4 0 Ribosomal protein L21e DZR PF12773.2 ESA14051.1 - 0.5 10.2 41.9 1 9.2 3.2 4.6 1 1 3 4 4 4 0 Double zinc ribbon RsbU_N PF08673.5 ESA14051.1 - 0.83 9.7 2.8 34 4.5 0.0 3.0 3 0 0 3 3 3 0 Phosphoserine phosphatase RsbU, N-terminal domain Cytochrom_C PF00034.16 ESA14051.1 - 1.6 9.6 12.9 14 6.5 0.7 3.5 3 0 0 3 3 3 0 Cytochrome c Cytochrom_c3_2 PF14537.1 ESA14051.1 - 3.8 7.9 51.7 0.57 10.5 10.1 4.4 1 1 2 3 3 3 0 Cytochrome c3 Ras PF00071.17 ESA14052.1 - 1.8e-66 222.5 0.1 2.5e-66 222.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA14052.1 - 4.8e-21 75.4 0.1 1e-20 74.4 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESA14052.1 - 3.4e-14 52.4 0.1 4.4e-14 52.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA14052.1 - 5.4e-07 28.9 0.0 7.7e-07 28.4 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA14052.1 - 1.5e-06 27.8 0.1 4.8e-06 26.1 0.0 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA14052.1 - 8.9e-05 22.4 0.1 0.00026 20.9 0.0 1.7 1 1 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESA14052.1 - 0.00048 19.3 0.2 0.00062 19.0 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ESA14052.1 - 0.0088 15.2 0.1 0.04 13.1 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESA14052.1 - 0.0093 15.2 0.0 0.13 11.5 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.1 ESA14052.1 - 0.018 15.0 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 ESA14052.1 - 0.036 13.5 0.0 0.11 12.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Enolase_N PF03952.11 ESA14052.1 - 0.042 13.7 0.1 0.082 12.8 0.1 1.4 1 0 0 1 1 1 0 Enolase, N-terminal domain G-alpha PF00503.15 ESA14052.1 - 0.057 12.0 5.7 0.63 8.6 1.2 2.8 1 1 1 2 2 2 0 G-protein alpha subunit AAA_22 PF13401.1 ESA14052.1 - 0.081 13.0 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA14052.1 - 0.76 10.0 3.1 3.8 7.8 2.2 2.0 1 1 0 1 1 1 0 ABC transporter Pkinase PF00069.20 ESA14053.1 - 3.6e-74 249.1 0.0 4.4e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14053.1 - 1.3e-31 109.6 0.0 1.6e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA14053.1 - 2.4e-05 23.4 0.0 8.7e-05 21.6 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA14053.1 - 0.00045 20.0 0.0 0.00093 18.9 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA14053.1 - 0.0018 17.2 0.0 0.022 13.7 0.0 2.1 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA14053.1 - 0.017 14.4 0.1 0.052 12.9 0.0 1.8 2 0 0 2 2 2 0 RIO1 family SPT16 PF08644.6 ESA14054.1 - 2.3e-54 183.3 0.0 2.3e-54 183.3 0.0 2.3 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) MFS_1 PF07690.11 ESA14055.1 - 0.022 13.4 0.2 0.023 13.4 0.1 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily Arrestin_N PF00339.24 ESA14056.1 - 4.7e-12 45.9 0.2 1.1e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA14056.1 - 0.0023 18.0 1.7 0.0056 16.7 0.1 2.1 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain WASH-7_mid PF14744.1 ESA14057.1 - 0.021 13.6 0.5 0.023 13.5 0.3 1.0 1 0 0 1 1 1 0 WASH complex subunit 7 SE PF08491.5 ESA14057.1 - 0.063 12.0 0.1 0.2 10.4 0.0 1.4 1 1 1 2 2 2 0 Squalene epoxidase VASP_tetra PF08776.6 ESA14057.1 - 0.066 12.5 4.3 1.3 8.4 1.5 2.9 1 1 1 2 2 2 0 VASP tetramerisation domain DinI PF06183.8 ESA14057.1 - 0.11 12.5 1.8 9.2 6.3 0.0 3.0 1 1 2 3 3 3 0 DinI-like family VPR PF00522.13 ESA14057.1 - 0.12 12.1 0.2 2.9 7.7 0.1 1.7 1 1 1 2 2 2 0 VPR/VPX protein DUF1601 PF07671.6 ESA14057.1 - 0.17 11.5 3.6 12 5.6 0.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1601) Cep57_MT_bd PF06657.8 ESA14057.1 - 0.26 11.2 1.8 5.8 6.9 0.0 2.4 1 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DrrA_P4M PF14860.1 ESA14057.1 - 0.69 9.6 4.8 2.6 7.7 1.6 2.1 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Antimicrobial_7 PF08102.6 ESA14057.1 - 7.5 6.6 8.9 44 4.1 0.1 3.1 1 1 2 3 3 3 0 Scorpion antimicrobial peptide CAF-1_p150 PF11600.3 ESA14058.1 - 0.0048 16.3 3.1 0.0065 15.8 2.1 1.1 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal ORC6 PF05460.8 ESA14058.1 - 0.27 10.2 6.7 0.33 10.0 4.6 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Methyltransf_11 PF08241.7 ESA14061.1 - 4.7e-09 36.6 0.0 8.8e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA14061.1 - 1e-08 35.0 0.0 2e-08 34.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA14061.1 - 2.6e-08 33.5 0.0 1.5e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA14061.1 - 3.7e-08 33.6 0.0 8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA14061.1 - 9.2e-05 21.8 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA14061.1 - 0.00018 22.0 0.0 0.0013 19.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA14061.1 - 0.00024 20.3 0.0 0.00078 18.6 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA14061.1 - 0.0011 19.3 0.0 0.0084 16.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 ESA14061.1 - 0.0017 18.3 0.0 0.0054 16.7 0.0 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.12 ESA14061.1 - 0.0061 15.6 0.0 0.018 14.1 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase DUF562 PF04763.7 ESA14064.1 - 0.065 12.4 0.1 0.069 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF562) FIBP PF05427.6 ESA14068.1 - 0.035 13.3 0.2 0.053 12.7 0.2 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) ParBc_2 PF08857.6 ESA14070.1 - 0.065 13.0 0.1 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative ParB-like nuclease DUF3007 PF11460.3 ESA14070.1 - 0.39 10.7 2.1 0.91 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) NAPRTase PF04095.11 ESA14072.1 - 3.7e-11 42.7 0.0 5.2e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Pkinase_Tyr PF07714.12 ESA14076.1 - 0.047 12.7 0.0 0.047 12.7 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase WLM PF08325.5 ESA14077.1 - 5.4e-43 147.0 0.1 6.7e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 WLM domain zf-RanBP PF00641.13 ESA14077.1 - 7.6e-07 28.1 0.7 1.4e-06 27.3 0.5 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF45 PF01863.12 ESA14077.1 - 0.0025 17.6 0.2 0.005 16.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 SprT-like PF10263.4 ESA14077.1 - 0.096 12.3 0.1 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 SprT-like family LRR_4 PF12799.2 ESA14080.1 - 2.2e-05 23.9 5.2 0.00091 18.7 0.4 4.3 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) Cluap1 PF10234.4 ESA14080.1 - 0.0013 18.0 13.9 0.0021 17.3 9.6 1.3 1 0 0 1 1 1 1 Clusterin-associated protein-1 LRR_8 PF13855.1 ESA14080.1 - 0.0028 17.3 3.1 0.034 13.9 0.1 3.2 2 1 0 2 2 2 1 Leucine rich repeat NPV_P10 PF05531.7 ESA14080.1 - 0.008 16.4 9.9 0.43 10.8 1.6 3.3 2 1 2 4 4 4 1 Nucleopolyhedrovirus P10 protein DUF885 PF05960.6 ESA14080.1 - 0.0098 15.0 3.3 0.013 14.6 2.3 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) DUF745 PF05335.8 ESA14080.1 - 0.015 14.8 6.2 0.015 14.8 4.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Spc7 PF08317.6 ESA14080.1 - 0.062 11.9 20.4 0.1 11.2 14.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.1 ESA14080.1 - 0.1 11.5 2.4 0.11 11.4 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Corona_S2 PF01601.11 ESA14080.1 - 0.22 9.5 2.6 0.31 9.0 1.8 1.3 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein LRR_7 PF13504.1 ESA14080.1 - 0.28 11.5 2.3 51 4.7 0.1 4.5 4 0 0 4 4 3 0 Leucine rich repeat Erp_C PF06780.6 ESA14080.1 - 0.42 10.4 23.5 1.3 8.9 12.5 2.4 2 0 0 2 2 2 0 Erp protein C-terminus Laminin_II PF06009.7 ESA14080.1 - 0.66 9.7 12.5 0.46 10.2 1.0 2.6 1 1 0 2 2 2 0 Laminin Domain II DUF4208 PF13907.1 ESA14080.1 - 0.86 9.8 16.7 0.56 10.4 3.4 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Cob_adeno_trans PF01923.13 ESA14080.1 - 1 9.1 7.8 5.5 6.7 3.7 2.8 1 1 1 2 2 2 0 Cobalamin adenosyltransferase DUF641 PF04859.7 ESA14080.1 - 1.2 8.9 14.1 3.1 7.5 6.5 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) APG6 PF04111.7 ESA14080.1 - 1.3 7.9 25.1 2 7.3 17.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 ESA14080.1 - 1.8 8.0 25.0 2.6 7.6 14.8 2.1 1 1 1 2 2 2 0 IncA protein SlyX PF04102.7 ESA14080.1 - 4 7.8 13.3 22 5.4 0.2 2.7 1 1 0 2 2 2 0 SlyX DUF3450 PF11932.3 ESA14080.1 - 4.1 6.5 11.8 23 4.1 8.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ALMT PF11744.3 ESA14080.1 - 6.2 5.3 7.0 8.2 4.9 4.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1664 PF07889.7 ESA14080.1 - 6.5 6.5 11.1 20 5.0 7.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) P4Ha_N PF08336.6 ESA14080.1 - 8.2 6.2 19.1 1.2 8.9 6.5 2.9 1 1 2 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region PRD PF00874.15 ESA14080.1 - 8.4 6.5 16.0 0.14 12.3 2.8 2.6 1 1 1 2 2 2 0 PRD domain UPF0184 PF03670.8 ESA14081.1 - 0.00027 21.0 14.6 0.15 12.2 0.5 3.6 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0184) Nucleic_acid_bd PF13820.1 ESA14081.1 - 0.0031 17.1 2.3 0.41 10.2 0.1 2.7 2 0 0 2 2 2 2 Putative nucleic acid-binding region Tower PF09121.5 ESA14081.1 - 0.041 13.8 0.9 0.041 13.8 0.6 2.4 2 0 0 2 2 2 0 Tower Reo_sigmaC PF04582.7 ESA14081.1 - 0.12 11.5 4.0 0.036 13.2 0.5 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein CHD5 PF04420.9 ESA14081.1 - 8.6 6.0 18.3 0.026 14.1 2.4 3.2 1 1 2 3 3 3 0 CHD5-like protein zf-CCHC_4 PF14392.1 ESA14082.1 - 0.02 14.5 1.1 0.041 13.5 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle KSR1-SAM PF13543.1 ESA14082.1 - 0.085 12.6 0.1 0.12 12.1 0.1 1.4 1 1 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 PLU-1 PF08429.6 ESA14082.1 - 0.09 11.6 0.0 0.096 11.5 0.0 1.0 1 0 0 1 1 1 0 PLU-1-like protein zf-CCHC PF00098.18 ESA14082.1 - 0.11 12.4 2.9 0.19 11.6 2.0 1.4 1 0 0 1 1 1 0 Zinc knuckle Copper-fist PF00649.13 ESA14082.1 - 0.14 11.4 7.6 0.09 11.9 3.1 2.0 2 0 0 2 2 2 0 Copper fist DNA binding domain PIF1 PF05970.9 ESA14084.1 - 1.5e-47 162.3 1.6 1e-24 87.1 0.1 2.0 1 1 1 2 2 2 2 PIF1-like helicase AAA_19 PF13245.1 ESA14084.1 - 0.05 13.3 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain Pkinase PF00069.20 ESA14087.1 - 2.1e-31 109.0 0.0 2.6e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14087.1 - 8.5e-09 34.8 0.0 1.6e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA14087.1 - 0.00017 20.6 0.0 0.0058 15.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA14087.1 - 0.00045 20.0 0.1 0.064 12.9 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family DNA_pol_B_palm PF14792.1 ESA14088.1 - 3.1e-18 65.8 0.0 5.4e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.1 ESA14088.1 - 4.9e-17 61.8 0.9 2.7e-16 59.4 1.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_thumb PF14791.1 ESA14088.1 - 8.6e-08 31.7 0.0 2.2e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESA14088.1 - 0.00013 21.3 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.1 ESA14088.1 - 0.0026 17.9 0.0 0.0048 17.0 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain Sel1 PF08238.7 ESA14089.1 - 1.6e-54 181.1 16.2 6e-10 39.4 0.0 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA14089.1 - 3.2e-06 26.9 9.8 0.015 15.2 0.2 4.0 3 1 0 3 3 3 3 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA14089.1 - 0.0011 19.1 0.5 3.3 7.8 0.0 3.8 2 1 2 4 4 4 1 Predicted AdoMet-dependent methyltransferase TPR_6 PF13174.1 ESA14089.1 - 0.0014 18.9 9.3 1.2 9.7 0.2 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA14089.1 - 0.0083 16.0 17.1 0.18 11.7 0.0 5.2 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA14089.1 - 0.024 14.2 22.1 0.81 9.3 0.9 4.9 1 1 3 4 4 4 0 TPR repeat TPR_7 PF13176.1 ESA14089.1 - 0.042 13.6 4.1 4.1 7.4 0.4 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TFIIB PF00382.14 ESA14089.1 - 0.27 11.0 2.0 29 4.5 0.0 4.1 5 0 0 5 5 5 0 Transcription factor TFIIB repeat TPR_16 PF13432.1 ESA14089.1 - 0.34 11.6 3.7 26 5.6 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 ESA14089.1 - 1 10.1 3.7 32 5.7 0.1 4.4 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat RasGEF PF00617.14 ESA14090.1 - 1.3e-50 171.7 0.2 2.6e-50 170.7 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 ESA14090.1 - 2.3e-15 56.5 2.2 4.2e-15 55.7 0.1 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif Miro PF08477.8 ESA14090.1 - 3e-10 40.6 0.1 1.2e-09 38.7 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Ras PF00071.17 ESA14090.1 - 2e-08 33.8 0.0 4.7e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Ras family AAA_17 PF13207.1 ESA14090.1 - 0.052 14.3 0.1 0.3 11.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain HypA PF01155.14 ESA14091.1 - 0.0025 17.5 7.3 0.13 11.9 0.0 4.3 4 0 0 4 4 4 2 Hydrogenase expression/synthesis hypA family DZR PF12773.2 ESA14091.1 - 0.23 11.3 13.2 2 8.2 1.6 4.0 4 0 0 4 4 4 0 Double zinc ribbon V-SNARE PF05008.10 ESA14091.1 - 7.7 6.7 9.2 4.7 7.4 0.0 4.3 5 0 0 5 5 5 0 Vesicle transport v-SNARE protein N-terminus Aminotran_3 PF00202.16 ESA14092.1 - 7.2e-42 143.4 0.0 1.4e-41 142.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.1 ESA14092.1 - 1.5e-08 34.4 0.0 2.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF3605 PF12239.3 ESA14094.1 - 2.3e-33 115.2 1.6 2.6e-33 115.0 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Ins_P5_2-kin PF06090.7 ESA14096.1 - 0.023 13.7 0.1 0.03 13.3 0.1 1.3 1 1 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase AAA_18 PF13238.1 ESA14096.1 - 0.035 14.4 2.3 0.056 13.7 1.6 1.6 1 1 0 1 1 1 0 AAA domain Syntaxin-6_N PF09177.6 ESA14096.1 - 0.053 13.9 2.4 0.19 12.1 0.1 2.7 2 1 1 3 3 3 0 Syntaxin 6, N-terminal EF-hand_10 PF14788.1 ESA14096.1 - 0.075 12.7 0.2 0.18 11.5 0.1 1.7 1 0 0 1 1 1 0 EF hand CCDC155 PF14662.1 ESA14097.1 - 0.013 15.0 1.9 0.024 14.2 1.3 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 DUF904 PF06005.7 ESA14097.1 - 0.022 15.0 1.7 0.063 13.5 1.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF342 PF03961.8 ESA14097.1 - 0.44 8.8 3.3 0.69 8.2 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) XOO_2897-deam PF14440.1 ESA14100.1 - 0.016 14.8 0.2 0.025 14.2 0.1 1.5 1 1 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase DUF4100 PF13352.1 ESA14100.1 - 0.028 13.8 0.1 0.031 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) DUF3883 PF13020.1 ESA14100.1 - 0.078 12.7 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3883) CfAFP PF05264.6 ESA14101.1 - 0.35 10.6 5.7 0.44 10.3 4.0 1.2 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) Ran_BP1 PF00638.13 ESA14102.1 - 4.9e-51 171.9 2.0 6.9e-51 171.4 1.4 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 ESA14102.1 - 1.1e-06 28.3 0.4 8.2e-06 25.5 0.3 2.0 1 1 0 1 1 1 1 WH1 domain DUF1681 PF07933.9 ESA14102.1 - 7e-06 25.6 0.7 9.9e-06 25.2 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) AAA_16 PF13191.1 ESA14103.1 - 1.7e-06 28.1 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ESA14103.1 - 0.0073 15.2 0.0 0.0082 15.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 ESA14103.1 - 0.051 12.9 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF258 PF03193.11 ESA14103.1 - 0.052 12.7 0.0 0.057 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA14103.1 - 0.052 13.8 0.2 0.11 12.8 0.1 1.5 1 1 1 2 2 2 0 ABC transporter AAA_19 PF13245.1 ESA14103.1 - 0.061 13.0 0.0 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 ESA14103.1 - 0.079 13.1 0.9 0.22 11.6 0.2 1.8 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.1 ESA14103.1 - 0.099 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.5 ESA14103.1 - 0.11 11.7 0.1 0.35 10.0 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ATP-synt_ab PF00006.20 ESA14103.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.24 ESA14103.1 - 0.15 12.2 0.1 0.37 11.0 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) THUMP PF02926.12 ESA14104.1 - 2.5e-16 59.8 0.2 2.5e-16 59.8 0.1 2.0 2 1 0 3 3 3 1 THUMP domain Pro_isomerase PF00160.16 ESA14105.1 - 2.4e-41 141.5 0.1 2.6e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TLD PF07534.11 ESA14106.1 - 1.6e-16 60.5 3.4 3.3e-16 59.5 2.4 1.6 1 0 0 1 1 1 1 TLD zf-BED PF02892.10 ESA14107.1 - 4.9e-11 42.2 0.8 8.4e-11 41.4 0.6 1.4 1 0 0 1 1 1 1 BED zinc finger zf-met2 PF12907.2 ESA14107.1 - 0.00014 21.7 0.7 0.00033 20.5 0.5 1.7 1 0 0 1 1 1 1 Zinc-binding DBD_Tnp_Hermes PF10683.4 ESA14107.1 - 0.0026 17.2 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Hermes transposase DNA-binding domain Pox_H7 PF04787.7 ESA14107.1 - 0.046 13.5 1.5 0.058 13.1 0.2 1.7 2 1 0 2 2 2 0 Late protein H7 DUF3505 PF12013.3 ESA14107.1 - 0.1 12.8 0.8 0.17 12.1 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3505) THAP PF05485.7 ESA14107.1 - 0.13 12.4 2.2 0.27 11.4 1.5 1.7 1 1 0 1 1 1 0 THAP domain AAA_32 PF13654.1 ESA14107.1 - 0.38 9.3 5.2 0.43 9.1 3.6 1.1 1 0 0 1 1 1 0 AAA domain zf-H2C2_5 PF13909.1 ESA14107.1 - 1.7 8.9 4.1 0.83 10.0 0.6 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain PP_M1 PF03012.9 ESA14107.1 - 4.3 6.6 8.4 11 5.3 5.5 1.8 1 1 0 1 1 1 0 Phosphoprotein IPT PF01745.11 ESA14109.1 - 0.061 12.4 0.1 1.7 7.7 0.0 2.7 2 1 1 3 3 3 0 Isopentenyl transferase Pkinase_Tyr PF07714.12 ESA14114.1 - 2.4e-36 125.1 0.0 3.6e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14114.1 - 1.6e-34 119.2 0.1 6.8e-34 117.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA14114.1 - 0.00087 19.8 0.0 0.0019 18.7 0.0 1.6 1 0 0 1 1 1 1 Sel1 repeat Kinase-like PF14531.1 ESA14114.1 - 0.014 14.4 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA14114.1 - 0.014 15.1 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA14114.1 - 0.04 12.9 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1390 PF07150.6 ESA14114.1 - 0.75 9.1 12.2 0.25 10.6 6.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1390) TerD PF02342.13 ESA14116.1 - 4e-09 36.0 0.0 6.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ESA14116.1 - 1.3e-08 34.0 0.4 3.2e-08 32.8 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA14116.1 - 7.4e-05 22.3 0.1 0.00015 21.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Glyco_transf_4 PF13439.1 ESA14116.1 - 0.032 13.9 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 NMD3 PF04981.8 ESA14116.1 - 0.052 12.6 1.1 0.086 11.9 0.8 1.3 1 0 0 1 1 1 0 NMD3 family zf-RING_5 PF14634.1 ESA14116.1 - 0.14 11.8 2.8 0.38 10.5 1.9 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA14116.1 - 0.19 11.4 4.1 0.48 10.1 2.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sel1 PF08238.7 ESA14122.1 - 1.2e-39 133.8 16.3 4.5e-12 46.1 0.3 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ESA14122.1 - 0.026 14.1 1.8 0.026 14.1 1.2 2.8 2 1 0 3 3 3 0 TPR repeat MIT PF04212.13 ESA14122.1 - 0.03 14.1 7.6 0.64 9.9 1.2 3.2 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA14122.1 - 0.047 14.1 6.0 13 6.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA14122.1 - 3.3 7.7 10.9 4.9 7.1 1.3 3.8 1 1 2 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA14126.1 - 1.2e-11 44.3 0.0 1.2e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14126.1 - 2.3e-08 33.4 0.0 2.4e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA14127.1 - 3.6e-05 22.9 0.0 4.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14127.1 - 0.0086 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA14128.1 - 0.0034 16.5 0.1 0.0038 16.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA14128.1 - 0.078 12.1 0.0 0.081 12.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA14128.1 - 0.13 11.3 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Herpes_UL14 PF03580.9 ESA14129.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL14-like protein Myb_DNA-binding PF00249.26 ESA14129.1 - 0.1 12.6 0.8 5.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA14129.1 - 0.17 12.0 3.5 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain SET PF00856.23 ESA14130.1 - 0.077 13.2 0.3 0.089 13.0 0.2 1.1 1 0 0 1 1 1 0 SET domain Pkinase PF00069.20 ESA14132.1 - 2e-13 50.1 0.0 2.9e-13 49.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14132.1 - 4.2e-12 45.6 0.0 6.3e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Rad9 PF04139.8 ESA14132.1 - 0.017 14.2 0.7 0.025 13.7 0.5 1.2 1 0 0 1 1 1 0 Rad9 Pkinase_Tyr PF07714.12 ESA14134.1 - 0.01 14.9 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14134.1 - 0.022 13.8 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14135.1 - 4.8e-51 173.3 0.0 6.9e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14135.1 - 8.3e-50 169.3 3.1 1.4e-49 168.6 0.6 2.0 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA14135.1 - 0.023 14.4 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA14135.1 - 0.12 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF678 PF05077.7 ESA14135.1 - 0.96 9.4 6.6 0.92 9.5 1.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Nucleoporin_C PF03177.9 ESA14136.1 - 4.8e-18 65.0 5.2 3.2e-16 59.0 1.2 2.7 2 1 1 3 3 3 2 Non-repetitive/WGA-negative nucleoporin C-terminal Far-17a_AIG1 PF04750.9 ESA14137.1 - 0.00041 19.5 12.1 0.00068 18.8 8.3 1.5 1 1 0 1 1 1 1 FAR-17a/AIG1-like protein PSD5 PF07637.6 ESA14138.1 - 0.035 14.1 0.3 0.12 12.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1595) VWA_2 PF13519.1 ESA14139.1 - 1.9e-13 50.8 0.0 3e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA14139.1 - 4.8e-11 42.6 0.3 8.9e-11 41.8 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain BACK PF07707.10 ESA14139.1 - 0.00018 21.3 1.0 0.00047 19.9 0.1 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA14140.1 - 9.1e-13 47.8 0.8 3.2e-11 42.8 0.6 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14140.1 - 3.1e-12 46.2 1.8 3.7e-10 39.4 1.2 2.0 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA14140.1 - 0.11 12.1 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2089 PF09862.4 ESA14142.1 - 0.04 13.6 0.2 0.048 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) DNA_pol3_beta PF00712.14 ESA14142.1 - 0.074 12.9 0.7 0.081 12.8 0.5 1.1 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain Ribonuclease_3 PF00636.21 ESA14142.1 - 0.1 13.0 0.2 0.11 12.9 0.2 1.1 1 0 0 1 1 1 0 Ribonuclease III domain Myb_DNA-bind_6 PF13921.1 ESA14143.1 - 3.7e-14 52.5 9.0 2.2e-10 40.4 0.1 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA14143.1 - 5.6e-09 35.9 1.1 0.0012 18.8 0.0 2.5 2 1 0 2 2 2 2 Myb-like DNA-binding domain DUF4313 PF14190.1 ESA14143.1 - 0.022 14.4 0.2 0.055 13.1 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4313) Myb_DNA-bind_2 PF08914.6 ESA14143.1 - 0.067 13.0 0.5 0.067 13.0 0.3 2.9 2 1 1 3 3 3 0 Rap1 Myb domain RNase_H PF00075.19 ESA14146.1 - 2.9e-05 24.4 0.7 0.00019 21.7 0.5 1.9 1 1 0 1 1 1 1 RNase H Myb_DNA-bind_4 PF13837.1 ESA14150.1 - 0.00079 19.5 2.7 0.00079 19.5 1.9 2.6 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain YmgB PF10798.3 ESA14150.1 - 0.014 15.1 0.2 0.037 13.8 0.1 1.7 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR Pkinase_Tyr PF07714.12 ESA14151.1 - 1.9e-09 37.0 2.9 4.3e-09 35.8 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14151.1 - 8.5e-06 25.0 0.1 8.5e-06 25.0 0.1 2.0 2 1 0 2 2 2 1 Protein kinase domain TRA-1_regulated PF02343.11 ESA14151.1 - 0.00086 18.8 0.3 0.0025 17.3 0.2 1.7 1 0 0 1 1 1 1 TRA-1 regulated protein R03H10.4 Sec34 PF04136.10 ESA14151.1 - 0.0013 18.4 9.2 0.14 11.8 0.4 2.5 1 1 0 2 2 2 2 Sec34-like family Spectrin PF00435.16 ESA14151.1 - 0.21 11.9 3.7 0.36 11.1 0.2 2.8 2 2 0 2 2 2 0 Spectrin repeat MCPsignal PF00015.16 ESA14151.1 - 2.2 7.7 6.0 2.7 7.4 0.3 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4413 PF14372.1 ESA14151.1 - 5.4 7.0 8.8 6 6.9 0.1 4.1 3 1 2 5 5 5 0 Domain of unknown function (DUF4413) Pkinase_Tyr PF07714.12 ESA14152.1 - 8.1e-45 152.9 4.3 3.7e-44 150.7 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14152.1 - 6e-37 127.1 0.2 6e-37 127.1 0.2 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA14152.1 - 1.1e-15 57.6 2.7 6.7e-07 29.7 0.0 3.5 3 0 0 3 3 3 2 Sel1 repeat TRA-1_regulated PF02343.11 ESA14152.1 - 0.00051 19.5 0.1 0.0013 18.2 0.1 1.7 1 0 0 1 1 1 1 TRA-1 regulated protein R03H10.4 Sec34 PF04136.10 ESA14152.1 - 0.0079 15.9 6.2 0.1 12.2 0.0 3.2 3 0 0 3 3 3 1 Sec34-like family Kdo PF06293.9 ESA14152.1 - 0.015 14.3 0.1 0.029 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Baculo_PEP_C PF04513.7 ESA14152.1 - 0.027 14.3 0.8 0.27 11.0 0.1 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESA14152.1 - 0.21 11.4 8.4 0.037 13.8 0.8 3.1 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) TPR_8 PF13181.1 ESA14152.1 - 4.9 7.1 6.8 28 4.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA14153.1 - 1.2e-42 145.8 0.0 2.6e-42 144.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14153.1 - 3.1e-35 121.5 1.3 4.6e-35 121.0 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA14153.1 - 3.4e-16 59.3 4.8 1.1e-07 32.2 0.1 2.7 2 0 0 2 2 2 2 Sel1 repeat PhageMin_Tail PF10145.4 ESA14153.1 - 0.00097 18.8 0.6 0.0021 17.7 0.4 1.5 1 0 0 1 1 1 1 Phage-related minor tail protein TRA-1_regulated PF02343.11 ESA14153.1 - 0.0011 18.4 0.1 0.0043 16.5 0.1 2.0 1 0 0 1 1 1 1 TRA-1 regulated protein R03H10.4 Syntaxin_2 PF14523.1 ESA14153.1 - 0.0036 17.3 2.7 0.091 12.7 0.8 2.9 2 1 1 3 3 3 1 Syntaxin-like protein Hormone_1 PF00103.15 ESA14153.1 - 0.0063 15.8 2.5 0.015 14.6 1.7 1.6 1 0 0 1 1 1 1 Somatotropin hormone family MCPsignal PF00015.16 ESA14153.1 - 0.017 14.6 1.4 0.034 13.6 1.0 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TPR_6 PF13174.1 ESA14153.1 - 0.025 14.9 0.7 5.4 7.7 0.0 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat Kdo PF06293.9 ESA14153.1 - 0.027 13.5 0.0 0.054 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Lipoprot_C PF08794.5 ESA14153.1 - 0.055 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Lipoprotein GNA1870 C terminal like Mod_r PF07200.8 ESA14153.1 - 0.13 12.2 6.3 0.36 10.7 4.4 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CheB_methylest PF01339.12 ESA14153.1 - 0.17 11.3 0.0 0.43 9.9 0.0 1.6 1 0 0 1 1 1 0 CheB methylesterase DUF972 PF06156.8 ESA14153.1 - 0.18 12.1 9.3 0.8 10.0 2.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF948 PF06103.6 ESA14153.1 - 0.35 10.7 2.8 1.1 9.2 1.9 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 ESA14153.1 - 0.35 9.9 2.6 0.55 9.3 1.8 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein YtxH PF12732.2 ESA14153.1 - 0.41 11.0 3.7 3.2 8.1 0.5 2.8 1 1 1 2 2 2 0 YtxH-like protein zf-C4H2 PF10146.4 ESA14153.1 - 1.3 8.9 6.9 4.1 7.3 4.6 1.9 1 1 0 1 1 1 0 Zinc finger-containing protein DASH_Dad2 PF08654.5 ESA14153.1 - 1.7 8.7 7.5 8.6 6.4 0.8 2.9 2 0 0 2 2 2 0 DASH complex subunit Dad2 Cep57_MT_bd PF06657.8 ESA14153.1 - 8.8 6.3 7.4 14 5.6 2.3 2.9 2 1 1 3 3 2 0 Centrosome microtubule-binding domain of Cep57 ABC_membrane PF00664.18 ESA14156.1 - 4.4e-31 108.3 27.8 2.2e-22 79.7 7.6 4.2 3 1 1 4 4 4 3 ABC transporter transmembrane region ABC_tran PF00005.22 ESA14156.1 - 4.6e-20 72.3 0.0 1.3e-19 70.8 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 ESA14156.1 - 0.0014 18.6 0.0 0.0033 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Dynamin_N PF00350.18 ESA14156.1 - 0.0069 16.2 0.6 0.023 14.5 0.2 2.1 2 0 0 2 2 2 1 Dynamin family T2SE PF00437.15 ESA14156.1 - 0.0088 14.9 0.0 0.028 13.3 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.1 ESA14156.1 - 0.02 15.2 2.1 0.12 12.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 ESA14156.1 - 0.022 14.2 0.2 0.085 12.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 ESA14156.1 - 0.029 13.9 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.1 ESA14156.1 - 0.054 13.4 0.1 0.054 13.4 0.0 3.6 4 1 0 4 4 4 0 AAA domain Miro PF08477.8 ESA14156.1 - 0.057 13.9 0.3 0.31 11.5 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein AAA_25 PF13481.1 ESA14156.1 - 0.078 12.3 0.0 0.35 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 ESA14156.1 - 0.18 10.9 2.2 0.33 10.0 0.0 2.3 2 1 1 3 3 3 0 Zeta toxin MMR_HSR1 PF01926.18 ESA14156.1 - 0.25 11.3 2.7 0.5 10.3 0.1 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.14 ESA14156.1 - 0.6 9.3 5.9 1.1 8.4 0.1 3.1 4 0 0 4 4 4 0 RecF/RecN/SMC N terminal domain zf-AN1 PF01428.11 ESA14157.1 - 4.2e-10 39.3 6.0 7.7e-10 38.4 4.2 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.10 ESA14157.1 - 0.019 15.1 1.7 0.035 14.3 1.2 1.5 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain IBR PF01485.16 ESA14157.1 - 0.27 11.1 9.3 0.8 9.6 6.4 1.9 1 1 0 1 1 1 0 IBR domain TB2_DP1_HVA22 PF03134.14 ESA14158.1 - 8.4e-29 99.1 2.7 1.1e-28 98.7 1.9 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Pro_racemase PF05544.6 ESA14159.1 - 1.9e-79 266.8 0.0 2.6e-79 266.4 0.0 1.2 1 0 0 1 1 1 1 Proline racemase DUF771 PF05595.6 ESA14159.1 - 0.00073 19.3 0.5 0.18 11.7 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF771) PhzC-PhzF PF02567.11 ESA14159.1 - 0.03 13.5 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein Abhydrolase_6 PF12697.2 ESA14160.1 - 3.5e-10 40.1 0.0 5.9e-10 39.4 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA14160.1 - 4.5e-10 39.4 0.0 6e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESA14160.1 - 3.8e-06 26.2 0.1 6.7e-06 25.4 0.0 1.7 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 ESA14160.1 - 0.0002 20.9 0.0 0.043 13.3 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.8 ESA14160.1 - 0.002 17.5 0.0 0.0028 17.1 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.11 ESA14160.1 - 0.0021 17.5 0.1 0.19 11.1 0.0 2.2 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.5 ESA14160.1 - 0.032 14.1 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Hydrolase_4 PF12146.3 ESA14160.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase DUF4344 PF14247.1 ESA14160.1 - 0.077 12.6 0.1 7.6 6.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4344) Tetraspannin PF00335.15 ESA14161.1 - 1.1e-13 50.9 9.9 1.6e-13 50.4 6.9 1.2 1 0 0 1 1 1 1 Tetraspanin family Sds3 PF08598.6 ESA14162.1 - 1.3e-12 47.7 13.7 2e-12 47.1 9.5 1.2 1 0 0 1 1 1 1 Sds3-like ASFV_L11L PF05293.6 ESA14164.1 - 0.74 9.9 6.7 1 9.5 0.1 3.0 2 1 0 2 2 2 0 African swine fever virus (ASFV) L11L protein DPBB_1 PF03330.13 ESA14166.1 - 3.4e-13 49.3 0.0 8.3e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Barwin PF00967.12 ESA14166.1 - 0.00078 19.1 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 Barwin family OppC_N PF12911.2 ESA14166.1 - 0.0074 15.6 0.6 0.015 14.6 0.4 1.5 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C ETRAMP PF09716.5 ESA14166.1 - 0.0081 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Cerato-platanin PF07249.7 ESA14166.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 Cerato-platanin Tetraspannin PF00335.15 ESA14166.1 - 0.074 12.3 0.3 0.1 11.8 0.2 1.4 1 1 0 1 1 1 0 Tetraspanin family DUF2116 PF09889.4 ESA14166.1 - 0.075 12.8 0.4 0.075 12.8 0.2 2.1 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Rifin_STEVOR PF02009.11 ESA14166.1 - 0.091 12.3 0.6 0.12 11.9 0.4 1.1 1 0 0 1 1 1 0 Rifin/stevor family CAAD PF14159.1 ESA14166.1 - 0.1 12.2 0.4 0.17 11.5 0.3 1.3 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF221 PF02714.10 ESA14166.1 - 0.86 8.4 3.5 1 8.1 2.1 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF221 BCIP PF13862.1 ESA14167.1 - 1.5e-70 236.7 7.2 1.8e-70 236.3 5.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein HN PF00423.14 ESA14167.1 - 0.11 10.7 0.9 0.13 10.5 0.6 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase RRF_GI PF12614.3 ESA14167.1 - 0.16 11.8 1.4 0.34 10.7 0.3 1.9 2 0 0 2 2 2 0 Ribosome recycling factor Orn_Arg_deC_N PF02784.11 ESA14168.1 - 5.2e-75 251.8 0.0 6.7e-75 251.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 ESA14168.1 - 2.2e-32 111.2 0.1 4.2e-32 110.2 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain FemAB PF02388.11 ESA14168.1 - 0.16 10.6 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 FemAB family TPR_11 PF13414.1 ESA14169.1 - 1.9e-25 88.2 1.3 1.3e-16 59.9 0.1 2.6 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA14169.1 - 2e-19 68.3 0.2 2.3e-06 26.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA14169.1 - 1.3e-18 65.3 0.3 1.1e-05 24.8 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA14169.1 - 3.2e-09 37.2 0.0 3.4e-07 30.7 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA14169.1 - 1.3e-08 34.0 5.3 0.053 13.3 0.0 4.3 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESA14169.1 - 1.3e-08 34.5 0.1 3.4e-08 33.2 0.1 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA14169.1 - 5e-08 33.1 0.5 0.0015 18.8 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA14169.1 - 6.3e-07 29.0 0.9 0.03 14.4 0.1 4.0 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA14169.1 - 1.2e-06 28.5 0.1 0.34 11.6 0.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA14169.1 - 4.2e-06 26.5 0.2 0.011 15.5 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA14169.1 - 9.1e-05 21.9 0.0 0.59 10.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA14169.1 - 0.00019 21.2 0.3 0.35 10.7 0.0 3.3 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ESA14169.1 - 0.00033 20.9 3.3 0.26 11.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA14169.1 - 0.00082 19.4 0.0 0.0018 18.3 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 ESA14169.1 - 0.0018 17.4 0.2 0.061 12.3 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF2693 PF10902.3 ESA14169.1 - 0.85 9.5 4.6 0.2 11.6 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2693) PRELI PF04707.9 ESA14171.1 - 3.9e-42 143.4 0.1 4.5e-42 143.2 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family Pkinase PF00069.20 ESA14174.1 - 6.8e-14 51.6 0.1 1.2e-13 50.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA14174.1 - 9.2e-14 51.5 5.4 5.8e-06 26.7 0.1 2.7 2 0 0 2 2 2 2 Sel1 repeat Pkinase_Tyr PF07714.12 ESA14174.1 - 1.7e-12 46.9 0.0 3.7e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_1 PF00515.23 ESA14174.1 - 0.087 12.4 5.0 1.9 8.2 0.5 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA14174.1 - 0.099 12.9 0.6 2.8 8.3 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA14174.1 - 0.11 13.0 2.3 20 5.9 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA14174.1 - 0.12 13.0 0.2 0.85 10.3 0.1 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA14174.1 - 0.25 11.0 3.2 1.8 8.2 0.1 2.5 1 1 1 2 2 2 0 TPR repeat TPR_2 PF07719.12 ESA14174.1 - 1.7 8.7 6.3 1.4 8.9 0.3 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat Vps39_2 PF10367.4 ESA14175.1 - 1.2e-19 70.4 0.1 4.1e-19 68.7 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 ESA14175.1 - 9e-07 28.5 18.7 1.5e-05 24.6 5.1 4.3 3 2 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.4 ESA14175.1 - 1.9e-06 27.8 12.3 6.2e-06 26.2 0.1 4.0 3 1 1 4 4 4 2 Vacuolar sorting protein 39 domain 1 TerB-N PF13208.1 ESA14175.1 - 0.0041 16.5 0.2 0.013 14.9 0.1 1.9 1 1 0 1 1 1 1 TerB-N DUF445 PF04286.7 ESA14175.1 - 0.027 13.9 2.2 0.12 11.8 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF445) TPR_1 PF00515.23 ESA14175.1 - 0.03 13.9 1.2 10 5.9 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DSPc PF00782.15 ESA14176.1 - 1.5e-33 115.1 0.0 1.8e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA14176.1 - 0.0039 16.5 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase AAA PF00004.24 ESA14177.1 - 6.9e-22 78.0 0.2 6.6e-21 74.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 ESA14177.1 - 0.016 15.0 1.1 0.027 14.3 0.1 1.8 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) Histone PF00125.19 ESA14177.1 - 0.022 14.8 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Polysacc_deac_1 PF01522.16 ESA14178.1 - 1.4e-22 79.6 0.0 3.9e-22 78.1 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA14178.1 - 0.00057 18.8 0.0 0.00075 18.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 SRI PF08236.6 ESA14178.1 - 0.12 12.3 0.1 13 5.8 0.1 2.2 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain PLAC8 PF04749.12 ESA14179.1 - 1.6e-24 86.5 14.2 1.9e-24 86.2 9.8 1.1 1 0 0 1 1 1 1 PLAC8 family DUF1218 PF06749.7 ESA14179.1 - 0.17 12.3 3.3 0.25 11.8 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) p450 PF00067.17 ESA14180.1 - 1.6e-38 132.4 3.7 6.2e-38 130.5 1.4 2.0 2 0 0 2 2 2 1 Cytochrome P450 DUF2347 PF09804.4 ESA14180.1 - 0.0059 15.9 0.9 0.011 15.0 0.6 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) RP-C_C PF11800.3 ESA14180.1 - 0.21 11.2 0.4 0.36 10.5 0.3 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region O-FucT PF10250.4 ESA14181.1 - 7.3e-10 38.4 0.0 1.1e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF1744 PF08490.7 ESA14181.1 - 0.075 11.5 0.1 0.093 11.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) Epimerase_2 PF02350.14 ESA14181.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Med15_fungi PF05397.7 ESA14182.1 - 2.3e-19 69.4 0.8 2.3e-19 69.4 0.5 4.5 4 0 0 4 4 4 1 Mediator complex subunit 15 Miro PF08477.8 ESA14183.1 - 0.00012 22.5 0.2 0.0033 17.9 0.0 3.0 2 0 0 2 2 2 1 Miro-like protein AAA_5 PF07728.9 ESA14183.1 - 0.0004 20.1 0.0 0.0016 18.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA14183.1 - 0.00057 20.0 1.3 0.0019 18.4 0.1 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 ESA14183.1 - 0.0033 17.5 1.1 0.27 11.4 0.0 4.2 4 0 0 4 4 4 1 RNA helicase AAA_22 PF13401.1 ESA14183.1 - 0.015 15.4 5.0 0.051 13.7 0.0 3.8 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.22 ESA14183.1 - 0.027 14.7 0.0 0.14 12.4 0.0 2.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 ESA14183.1 - 0.19 11.6 0.0 0.79 9.6 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 ESA14183.1 - 0.38 11.5 3.8 4.3 8.1 0.0 4.5 4 0 0 4 4 4 0 AAA domain FA_hydroxylase PF04116.8 ESA14184.1 - 1.8e-11 44.4 12.9 4.4e-11 43.1 5.4 2.3 2 1 0 2 2 2 2 Fatty acid hydroxylase superfamily TraT PF05818.7 ESA14185.1 - 0.03 13.7 0.0 0.07 12.5 0.0 1.6 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein hNIFK_binding PF12196.3 ESA14185.1 - 0.84 9.0 8.6 2 7.8 2.5 3.0 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK Cut8_N PF14482.1 ESA14185.1 - 3 7.9 5.9 2.3 8.3 2.2 2.3 2 0 0 2 2 2 0 Cut8 proteasome-binding domain ATP-sulfurylase PF01747.12 ESA14186.1 - 3.4e-87 291.2 0.3 4.7e-87 290.8 0.2 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 ESA14186.1 - 5.2e-54 181.9 0.0 8.7e-54 181.2 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain APS_kinase PF01583.15 ESA14186.1 - 2e-53 180.2 0.0 2.9e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase SH3_9 PF14604.1 ESA14187.1 - 2.2e-29 100.7 0.7 4.1e-15 55.0 0.1 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 ESA14187.1 - 4.2e-26 90.0 0.6 1.4e-14 53.1 0.1 2.2 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 ESA14187.1 - 5.5e-21 73.8 0.1 2.7e-12 45.9 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 ESA14187.1 - 0.00024 21.2 3.7 0.00092 19.3 0.0 2.7 3 0 0 3 3 3 1 Bacterial SH3 domain FCH PF00611.18 ESA14188.1 - 4.1e-24 84.5 1.1 4.1e-24 84.5 0.8 2.7 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Mod_r PF07200.8 ESA14188.1 - 0.0097 15.8 8.8 0.0097 15.8 6.1 2.3 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein DUF2458 PF10454.4 ESA14188.1 - 0.021 14.7 0.9 0.021 14.7 0.7 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF2458) CotJB PF12652.2 ESA14188.1 - 0.076 13.0 1.0 0.34 11.0 0.0 2.4 2 1 0 2 2 2 0 CotJB protein DUF3287 PF11690.3 ESA14188.1 - 0.25 11.4 7.6 0.28 11.2 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) Ion_trans PF00520.26 ESA14189.1 - 2.2e-24 85.8 11.1 2.2e-24 85.8 7.7 1.6 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.11 ESA14189.1 - 1.2e-12 47.3 2.4 1.2e-12 47.3 1.6 2.3 2 1 0 2 2 2 1 Ion channel DUF4446 PF14584.1 ESA14189.1 - 0.49 10.2 5.2 0.097 12.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) SAM_1 PF00536.25 ESA14190.1 - 1.6e-08 34.5 0.6 3.6e-08 33.4 0.2 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Chitin_synth_2 PF03142.10 ESA14191.1 - 1.4e-246 819.0 0.7 1.8e-246 818.6 0.5 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.16 ESA14191.1 - 1.9e-155 518.7 10.1 4.6e-155 517.4 7.0 1.5 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.6 ESA14191.1 - 1.3e-18 66.4 3.2 9.7e-16 57.2 2.5 3.4 3 0 0 3 3 3 1 DEK C terminal domain Glyco_trans_2_3 PF13632.1 ESA14191.1 - 4.8e-18 65.5 2.5 4.8e-18 65.5 1.7 2.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.23 ESA14191.1 - 2e-16 59.5 0.7 9.7e-09 34.9 0.0 3.6 3 0 0 3 3 3 3 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.1 ESA14191.1 - 3.2e-16 59.8 0.0 1.3e-13 51.2 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 ESA14191.1 - 1.5e-06 27.9 0.0 0.00033 20.3 0.0 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 ESA14191.1 - 1.4e-05 24.4 0.1 0.00038 19.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 DPCD PF14913.1 ESA14193.1 - 0.025 13.6 0.6 0.052 12.6 0.4 1.6 1 1 1 2 2 2 0 DPCD protein family PI31_Prot_N PF11566.3 ESA14193.1 - 0.15 11.6 3.2 0.086 12.4 0.8 1.7 2 0 0 2 2 2 0 PI31 proteasome regulator N-terminal DUF2872 PF11071.3 ESA14194.1 - 2.3 8.0 9.4 0.74 9.6 1.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2872) RcsC PF09456.5 ESA14194.1 - 6.4 6.4 10.8 1.8 8.2 0.3 3.1 4 0 0 4 4 4 0 RcsC Alpha-Beta-Loop (ABL) Carb_anhydrase PF00194.16 ESA14196.1 - 2.7e-26 92.0 0.0 8.9e-26 90.3 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase DUF4269 PF14091.1 ESA14196.1 - 0.044 13.7 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) S_100 PF01023.14 ESA14196.1 - 0.12 11.7 0.9 0.32 10.3 0.6 1.7 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain eIF3g PF12353.3 ESA14197.1 - 0.0026 17.6 6.4 0.0026 17.6 4.4 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RED_N PF07808.8 ESA14197.1 - 0.09 11.9 1.4 0.17 11.0 1.0 1.4 1 0 0 1 1 1 0 RED-like protein N-terminal region DUF2946 PF11162.3 ESA14197.1 - 0.27 11.4 3.8 0.61 10.3 2.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2946) PepSY_2 PF13670.1 ESA14197.1 - 2.7 7.9 6.1 4.9 7.1 4.3 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF3716 PF12511.3 ESA14197.1 - 3.9 7.1 9.6 12 5.5 6.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) Herpes_UL3 PF03369.8 ESA14197.1 - 9.7 6.1 9.3 4.4 7.2 3.0 2.2 1 1 1 2 2 2 0 Herpesvirus UL3 protein zf-C2H2 PF00096.21 ESA14198.1 - 1e-12 47.5 17.1 1.9e-07 31.0 0.7 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA14198.1 - 3.4e-10 39.6 20.4 5.2e-05 23.3 0.1 3.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA14198.1 - 5.9e-10 38.7 17.7 1.6e-05 24.8 0.8 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-TRAF PF02176.13 ESA14198.1 - 7.4e-05 23.0 0.4 7.4e-05 23.0 0.3 2.0 1 1 1 2 2 2 1 TRAF-type zinc finger zf-C2H2_6 PF13912.1 ESA14198.1 - 0.0011 18.8 1.0 0.022 14.6 0.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA14198.1 - 0.0021 18.1 7.6 0.05 13.7 0.1 3.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA14198.1 - 0.029 14.5 6.2 0.044 13.9 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type IBR PF01485.16 ESA14198.1 - 0.098 12.5 2.2 0.18 11.7 0.3 2.0 1 1 1 2 2 2 0 IBR domain zf-C2HC_2 PF13913.1 ESA14198.1 - 0.17 11.6 0.9 0.17 11.6 0.7 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type FeS PF04060.8 ESA14198.1 - 0.32 10.6 0.4 0.32 10.6 0.3 1.8 2 0 0 2 2 2 0 Putative Fe-S cluster zf-LYAR PF08790.6 ESA14198.1 - 0.39 10.4 2.9 5.3 6.8 0.0 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger RPAP2_Rtr1 PF04181.8 ESA14198.1 - 0.45 10.6 3.2 1.1 9.3 1.4 2.2 1 1 1 2 2 2 0 Rtr1/RPAP2 family zf-UBP PF02148.14 ESA14198.1 - 2.5 8.2 8.4 10 6.3 4.1 2.5 1 1 1 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF202 PF02656.10 ESA14199.1 - 1.2e-24 86.2 0.3 1.2e-24 86.2 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF1129 PF06570.6 ESA14199.1 - 0.0025 17.1 1.2 0.003 16.8 0.6 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1129) YtpI PF14007.1 ESA14199.1 - 0.0076 16.1 3.1 0.01 15.7 1.0 2.0 2 0 0 2 2 2 1 YtpI-like protein XK-related PF09815.4 ESA14199.1 - 0.022 13.7 0.2 0.035 13.1 0.0 1.3 1 1 0 1 1 1 0 XK-related protein MscS_TM PF12794.2 ESA14199.1 - 0.031 12.9 1.0 0.044 12.4 0.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 PMP22_Claudin PF00822.15 ESA14199.1 - 0.24 11.0 2.4 0.37 10.4 0.2 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF3784 PF12650.2 ESA14199.1 - 0.32 10.9 5.7 0.23 11.4 2.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) SdpI PF13630.1 ESA14199.1 - 0.45 10.2 6.4 0.099 12.3 1.6 1.9 2 0 0 2 2 2 0 SdpI/YhfL protein family Herpes_UL45 PF05473.7 ESA14199.1 - 0.76 9.1 4.7 66 2.8 0.0 2.4 2 1 0 2 2 2 0 UL45 protein Claudin_2 PF13903.1 ESA14199.1 - 8.1 6.1 8.7 99 2.5 6.0 2.1 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF3292 PF11696.3 ESA14200.1 - 0.11 10.4 5.7 0.17 9.7 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) HCV_NS5a_C PF12941.2 ESA14200.1 - 2.4 7.6 7.4 5.1 6.5 5.1 1.6 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region Na_trans_assoc PF06512.8 ESA14200.1 - 2.8 7.8 15.8 1.7 8.5 7.5 2.3 2 0 0 2 2 2 0 Sodium ion transport-associated DUF4407 PF14362.1 ESA14200.1 - 4 6.2 15.8 6.7 5.5 11.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ndc1_Nup PF09531.5 ESA14200.1 - 8.2 4.7 23.2 11 4.3 16.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HMG_box PF00505.14 ESA14201.1 - 4.4e-21 74.9 20.3 3.4e-13 49.6 3.6 3.3 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA14201.1 - 1.1e-14 54.4 17.7 7.1e-08 32.7 3.6 3.0 2 1 0 2 2 2 2 HMG-box domain Corona_S2 PF01601.11 ESA14201.1 - 0.021 12.9 0.5 0.03 12.4 0.3 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Serinc PF03348.10 ESA14201.1 - 0.19 10.4 0.9 0.43 9.2 0.6 1.6 1 0 0 1 1 1 0 Serine incorporator (Serinc) GCD14 PF08704.5 ESA14201.1 - 1.1 8.7 9.8 0.24 10.8 2.3 2.2 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Mucin PF01456.12 ESA14201.1 - 1.7 8.4 11.2 2.6 7.7 7.8 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Ribosomal_L21p PF00829.16 ESA14202.1 - 2.9e-18 65.8 1.4 3.4e-18 65.5 1.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein DUF3465 PF11948.3 ESA14202.1 - 0.054 13.3 0.4 1.2 8.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3465) UCH PF00443.24 ESA14203.1 - 6.6e-49 166.4 29.6 1e-47 162.5 17.8 3.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ESA14203.1 - 2.5e-20 72.3 4.8 5.5e-20 71.2 2.6 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 ESA14203.1 - 2.9e-16 59.7 20.2 3.5e-16 59.5 5.9 3.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-RING_3 PF14369.1 ESA14203.1 - 0.0069 16.3 0.4 0.053 13.5 0.1 2.5 2 0 0 2 2 2 1 zinc-finger IMD PF08397.6 ESA14204.1 - 0.019 14.3 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF1128 PF06569.6 ESA14204.1 - 0.11 12.2 0.2 0.28 10.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) DUF4263 PF14082.1 ESA14206.1 - 0.055 13.4 0.1 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4263) HMG_box PF00505.14 ESA14207.1 - 4e-07 30.2 0.1 1.1e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box BCDHK_Adom3 PF10436.4 ESA14209.1 - 0.004 16.6 0.0 0.0072 15.8 0.0 1.4 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase CENP-B_N PF04218.8 ESA14210.1 - 6.6e-06 25.4 0.4 1.1e-05 24.7 0.3 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_4 PF13613.1 ESA14210.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease TrbM PF07424.6 ESA14210.1 - 0.074 13.0 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 TrbM Consortin_C PF15281.1 ESA14210.1 - 0.1 12.1 1.3 0.14 11.6 0.0 1.8 2 1 0 2 2 2 0 Consortin C-terminus DUF3698 PF12479.3 ESA14210.1 - 0.11 12.5 0.4 0.16 12.1 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) HTH_Tnp_Tc5 PF03221.11 ESA14211.1 - 2.4e-12 46.4 0.1 5.3e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain MFS_2 PF13347.1 ESA14212.1 - 5.6e-06 25.0 26.3 0.00018 20.0 18.2 2.4 2 1 0 2 2 2 1 MFS/sugar transport protein PUCC PF03209.10 ESA14212.1 - 0.0001 21.1 0.7 0.0002 20.2 0.4 1.5 1 1 0 1 1 1 1 PUCC protein MFS_1_like PF12832.2 ESA14212.1 - 0.54 10.0 0.0 0.54 10.0 0.0 4.9 6 0 0 6 6 6 0 MFS_1 like family HMG_box PF00505.14 ESA14213.1 - 0.018 15.3 0.3 0.033 14.4 0.2 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box ThiC-associated PF13667.1 ESA14214.1 - 0.03 13.8 0.1 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 ThiC-associated domain Glutaredoxin2_C PF04399.8 ESA14214.1 - 0.11 12.1 0.2 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain RRM_1 PF00076.17 ESA14215.1 - 1.1e-22 79.4 0.0 1.8e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 ESA14215.1 - 7.1e-16 58.0 11.7 7.1e-16 58.0 8.1 4.8 3 2 2 5 5 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_6 PF14259.1 ESA14215.1 - 3.7e-15 55.6 0.0 7.5e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA14215.1 - 4.6e-08 32.7 0.0 1.2e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.17 ESA14215.1 - 0.014 14.4 9.7 0.045 12.7 3.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Gti1_Pac2 PF09729.4 ESA14215.1 - 0.099 12.5 10.1 0.78 9.5 0.7 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family Otopetrin PF03189.8 ESA14215.1 - 0.36 9.7 6.8 1.5 7.7 0.3 2.1 2 0 0 2 2 2 0 Otopetrin CDC45 PF02724.9 ESA14215.1 - 0.52 8.2 17.2 0.035 12.1 2.2 2.1 2 0 0 2 2 2 0 CDC45-like protein Folliculin PF11704.3 ESA14215.1 - 3.4 7.2 16.3 0.044 13.3 0.9 2.4 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Mitofilin PF09731.4 ESA14215.1 - 3.8 6.0 25.1 2.3 6.7 4.3 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein eIF-3_zeta PF05091.7 ESA14215.1 - 5.2 5.5 28.8 3.3 6.2 6.1 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) FLO_LFY PF01698.11 ESA14215.1 - 6.8 5.4 17.4 4.8 5.9 3.1 2.3 2 0 0 2 2 2 0 Floricaula / Leafy protein TCP PF03634.8 ESA14215.1 - 7.8 6.8 29.2 6 7.2 6.2 2.6 2 0 0 2 2 2 0 TCP family transcription factor FUN14 PF04930.10 ESA14216.1 - 8.2e-25 86.9 1.9 8.2e-25 86.9 1.3 1.7 2 1 0 2 2 2 1 FUN14 family EF-hand_1 PF00036.27 ESA14216.1 - 0.0011 18.1 0.2 0.002 17.3 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 ESA14216.1 - 0.0043 16.8 0.1 0.0088 15.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 ESA14216.1 - 0.022 14.0 0.2 0.043 13.1 0.1 1.4 1 0 0 1 1 1 0 EF hand HTH_34 PF13601.1 ESA14216.1 - 0.027 14.4 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain PadR PF03551.9 ESA14216.1 - 0.08 12.7 0.0 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family Dockerin_1 PF00404.13 ESA14216.1 - 0.16 11.6 0.3 0.31 10.8 0.2 1.5 1 0 0 1 1 1 0 Dockerin type I repeat VHS PF00790.14 ESA14219.1 - 6.8e-31 106.7 0.0 1.6e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.9 ESA14219.1 - 1.8e-08 34.2 0.2 4.1e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 GAT domain Dsh_C PF12316.3 ESA14219.1 - 0.055 13.5 6.6 0.12 12.4 4.6 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DDE_3 PF13358.1 ESA14220.1 - 0.0003 20.5 0.0 0.0012 18.6 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF2457 PF10446.4 ESA14220.1 - 0.14 10.8 22.5 0.15 10.7 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) DUF4484 PF14831.1 ESA14220.1 - 0.8 9.7 17.3 3.9 7.5 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) TRAP_alpha PF03896.11 ESA14220.1 - 2.2 7.2 15.1 2.1 7.2 2.5 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.9 ESA14220.1 - 2.6 5.9 18.1 1.4 6.8 4.5 2.2 2 0 0 2 2 2 0 CDC45-like protein Daxx PF03344.10 ESA14220.1 - 5.6 5.3 19.8 2.6 6.4 2.2 2.1 2 0 0 2 2 2 0 Daxx Family DUF1397 PF07165.6 ESA14221.1 - 0.061 12.5 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1397) RGS PF00615.14 ESA14221.1 - 0.19 11.8 4.0 0.19 11.8 0.7 2.4 1 1 0 2 2 2 0 Regulator of G protein signaling domain p450 PF00067.17 ESA14222.1 - 1.6e-47 162.1 0.0 1.8e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FERM_C PF09380.5 ESA14225.1 - 0.06 13.5 0.5 0.15 12.3 0.4 1.7 1 0 0 1 1 1 0 FERM C-terminal PH-like domain SpoVA PF03862.8 ESA14225.1 - 0.096 12.7 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 SpoVA protein DUF3456 PF11938.3 ESA14225.1 - 0.82 9.6 10.3 1.5 8.8 7.2 1.4 1 1 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP BTB PF00651.26 ESA14226.1 - 5.7e-20 71.3 0.1 1.2e-19 70.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14226.1 - 4.7e-05 23.1 0.5 0.00034 20.3 0.3 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch Cullin_binding PF03556.10 ESA14226.1 - 0.068 13.3 1.0 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 Cullin binding MIR PF02815.14 ESA14228.1 - 0.0029 17.1 0.1 0.018 14.5 0.1 2.2 1 1 0 1 1 1 1 MIR domain BTB PF00651.26 ESA14229.1 - 1.7e-20 73.0 0.2 2e-20 72.8 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF552 PF04472.7 ESA14229.1 - 0.11 12.3 0.0 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF552) TLD PF07534.11 ESA14230.1 - 7.2e-10 38.9 2.2 4e-09 36.5 0.4 2.6 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA14230.1 - 1.8e-06 27.6 2.7 3.4e-05 23.6 0.1 3.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch RPM2 PF08579.6 ESA14230.1 - 0.054 13.6 1.2 5 7.2 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) Toxin_64 PF15542.1 ESA14230.1 - 0.35 11.4 2.3 0.37 11.3 0.1 2.0 2 0 0 2 2 2 0 Putative toxin 64 DUF912 PF06024.7 ESA14231.1 - 0.024 14.7 0.8 0.024 14.7 0.6 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Lactamase_B_4 PF13691.1 ESA14232.1 - 3.5e-16 58.4 0.1 6.6e-16 57.5 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease AAA_11 PF13086.1 ESA14233.1 - 8e-10 38.6 3.0 1.3e-09 37.9 2.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA14233.1 - 0.0033 17.1 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 Part of AAA domain AAA PF00004.24 ESA14233.1 - 0.12 12.6 2.9 0.13 12.4 0.8 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) XdhC_C PF13478.1 ESA14233.1 - 0.17 12.2 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain ResIII PF04851.10 ESA14233.1 - 9.3 6.0 9.9 0.36 10.6 1.1 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit DUF2743 PF10899.3 ESA14234.1 - 0.08 12.3 1.7 0.18 11.1 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2743) Pkinase PF00069.20 ESA14235.1 - 1.2e-10 41.0 0.0 1.7e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14235.1 - 1.7e-09 37.1 0.0 3.2e-09 36.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2372 PF10178.4 ESA14240.1 - 0.017 15.2 0.2 0.038 14.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2372) MTBP_N PF14918.1 ESA14240.1 - 0.047 13.1 0.0 0.056 12.8 0.0 1.1 1 0 0 1 1 1 0 MDM2-binding zf-MYND PF01753.13 ESA14242.1 - 0.46 10.4 2.0 0.99 9.3 1.4 1.6 1 0 0 1 1 1 0 MYND finger Pkinase_Tyr PF07714.12 ESA14243.1 - 2.3e-15 56.3 0.0 2.7e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14243.1 - 7e-08 31.9 0.0 9.2e-08 31.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain AflR PF08493.5 ESA14244.1 - 2.1 7.2 6.6 0.27 10.2 1.7 1.6 2 0 0 2 2 2 0 Aflatoxin regulatory protein MGC-24 PF05283.6 ESA14244.1 - 2.6 7.7 5.9 3.7 7.3 4.0 1.3 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) DUF1033 PF06279.6 ESA14245.1 - 2.2 8.1 7.8 0.35 10.6 1.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1033) AAA_21 PF13304.1 ESA14245.1 - 3 7.7 8.0 0.57 10.0 2.1 1.9 2 0 0 2 2 2 0 AAA domain DUF148 PF02520.12 ESA14246.1 - 0.00088 19.0 0.9 0.0013 18.4 0.6 1.3 1 1 0 1 1 1 1 Domain of unknown function DUF148 DUF1542 PF07564.6 ESA14246.1 - 0.0031 17.4 0.6 0.0031 17.4 0.4 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF3657 PF12394.3 ESA14248.1 - 0.033 14.2 0.7 0.098 12.7 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3657) PB1 PF00564.19 ESA14248.1 - 0.08 12.6 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 PB1 domain CENP-P PF13096.1 ESA14249.1 - 4.9e-22 78.0 4.4 1.4e-21 76.6 0.8 2.7 2 1 0 2 2 2 1 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P DUF4588 PF15251.1 ESA14250.1 - 2.8e-06 27.5 5.5 1.3e-05 25.3 3.8 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) DUF273 PF03314.9 ESA14250.1 - 0.054 12.7 0.0 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function, DUF273 KH_1 PF00013.24 ESA14251.1 - 5.8e-09 35.4 0.6 1.7e-08 33.9 0.1 2.1 2 0 0 2 2 2 1 KH domain zf-CCHC PF00098.18 ESA14251.1 - 5.9e-09 35.4 10.1 0.0003 20.5 1.1 2.3 2 0 0 2 2 2 2 Zinc knuckle KH_3 PF13014.1 ESA14251.1 - 3.2e-07 29.8 0.1 1.1e-06 28.1 0.1 2.0 1 0 0 1 1 1 1 KH domain zf-CCHC_6 PF15288.1 ESA14251.1 - 0.0085 15.7 8.2 0.38 10.4 0.4 2.6 2 0 0 2 2 2 2 Zinc knuckle DnaJ_CXXCXGXG PF00684.14 ESA14251.1 - 0.016 15.2 6.9 0.037 14.0 4.8 1.5 1 0 0 1 1 1 0 DnaJ central domain zf-CCHC_4 PF14392.1 ESA14251.1 - 0.038 13.6 9.0 0.38 10.4 0.6 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESA14251.1 - 0.13 12.0 12.5 0.068 12.9 2.8 2.5 1 1 1 2 2 2 0 Zinc knuckle Nucleocap_ssRNA PF11128.3 ESA14251.1 - 0.13 11.7 0.6 0.87 9.0 0.0 2.1 2 0 0 2 2 2 0 Plant viral coat protein nucleocapsid Pantoate_transf PF02548.10 ESA14253.1 - 0.042 12.9 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase Rep_4 PF05797.6 ESA14255.1 - 0.0067 15.1 0.4 0.058 12.0 0.0 2.2 2 0 0 2 2 2 1 Yeast trans-acting factor (REP1/REP2) AAA_22 PF13401.1 ESA14255.1 - 0.32 11.1 2.4 30 4.7 0.4 3.1 3 0 0 3 3 3 0 AAA domain Acyl-CoA_dh_1 PF00441.19 ESA14256.1 - 2e-39 135.0 1.5 2.6e-39 134.7 1.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.6 ESA14256.1 - 3.2e-07 30.6 0.4 5.1e-07 29.9 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 ESA14256.1 - 0.022 14.2 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain TPR_10 PF13374.1 ESA14256.1 - 0.29 11.1 1.6 0.66 9.9 0.7 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA14257.1 - 9.7e-10 37.9 0.0 2.4e-05 23.5 0.0 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase BCS1_N PF08740.6 ESA14257.1 - 7.2e-09 35.5 0.1 0.16 11.5 0.0 3.9 4 0 0 4 4 4 3 BCS1 N terminal Pkinase PF00069.20 ESA14257.1 - 3.3e-08 33.0 1.5 2.4e-05 23.6 0.1 3.4 3 0 0 3 3 3 1 Protein kinase domain Frataxin_Cyay PF01491.11 ESA14257.1 - 0.0018 18.0 0.7 3.7 7.3 0.0 3.5 3 0 0 3 3 3 2 Frataxin-like domain Spt5-NGN PF03439.8 ESA14257.1 - 0.0082 15.8 1.9 28 4.5 0.0 4.8 5 0 0 5 5 5 0 Early transcription elongation factor of RNA pol II, NGN section DUF1811 PF08838.5 ESA14257.1 - 0.024 14.6 2.5 2.6 8.0 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1811) PTH2 PF01981.11 ESA14257.1 - 0.15 11.7 0.1 18 5.0 0.0 2.7 2 0 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 DZR PF12773.2 ESA14257.1 - 0.23 11.2 4.7 2.5 8.0 0.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon DUF3078 PF11276.3 ESA14259.1 - 0.0048 17.0 20.3 0.028 14.6 0.2 4.4 3 1 1 4 4 4 2 Protein of unknown function (DUF3078) BBS2_Mid PF14783.1 ESA14259.1 - 0.17 11.6 4.6 4.2 7.1 0.4 2.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region MHC_I PF00129.13 ESA14259.1 - 0.81 9.0 5.8 0.63 9.3 0.6 2.3 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Fer4_16 PF13484.1 ESA14259.1 - 2.7 8.7 8.1 8.8 7.1 0.1 2.9 3 1 0 3 3 3 0 4Fe-4S double cluster binding domain Swi5 PF07061.6 ESA14259.1 - 6.5 6.6 6.9 0.7 9.7 0.5 2.4 3 0 0 3 3 3 0 Swi5 MreB_Mbl PF06723.8 ESA14260.1 - 0.002 16.7 0.6 0.029 12.9 0.0 2.1 1 1 0 2 2 2 1 MreB/Mbl protein DJ-1_PfpI PF01965.19 ESA14260.1 - 0.0055 16.1 0.0 0.012 15.0 0.0 1.6 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4325 PF14213.1 ESA14260.1 - 1.8 8.2 5.7 9.3 5.9 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4325) ASC PF00858.19 ESA14261.1 - 0.12 10.9 0.6 0.34 9.5 0.1 1.8 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel Pkinase_Tyr PF07714.12 ESA14262.1 - 4.6e-20 71.7 0.5 1.4e-19 70.2 0.0 1.9 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14262.1 - 1e-17 64.1 0.8 1e-17 64.1 0.6 2.7 2 1 0 3 3 3 1 Protein kinase domain DZR PF12773.2 ESA14262.1 - 0.0027 17.4 4.0 0.18 11.6 0.3 2.4 2 0 0 2 2 2 2 Double zinc ribbon NMD3 PF04981.8 ESA14262.1 - 0.016 14.3 5.6 0.17 10.9 0.8 2.3 2 0 0 2 2 2 0 NMD3 family Kinase-like PF14531.1 ESA14262.1 - 0.1 11.5 2.1 0.13 11.2 0.1 2.1 3 0 0 3 3 3 0 Kinase-like DUF3795 PF12675.2 ESA14262.1 - 0.1 12.7 3.7 3.2 7.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3795) APH PF01636.18 ESA14262.1 - 0.12 12.0 0.1 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family NOB1_Zn_bind PF08772.6 ESA14262.1 - 0.51 10.2 4.8 4.2 7.2 0.9 2.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF1272 PF06906.6 ESA14262.1 - 0.68 9.8 4.5 1.4 8.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) XPA_N PF01286.13 ESA14262.1 - 3 7.6 9.9 2.6 7.7 0.4 2.5 2 0 0 2 2 2 0 XPA protein N-terminal zf-ribbon_3 PF13248.1 ESA14262.1 - 8.6 5.7 7.1 1.2 8.4 0.4 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Pkinase_Tyr PF07714.12 ESA14268.1 - 2.4e-14 53.0 0.0 3.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14268.1 - 3.4e-10 39.5 0.4 1.5e-09 37.4 0.3 1.8 1 1 0 1 1 1 1 Protein kinase domain Myb_DNA-bind_6 PF13921.1 ESA14269.1 - 8.2e-09 35.4 0.5 9.3e-09 35.2 0.4 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA14269.1 - 6.6e-06 26.0 0.1 7.6e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 ESA14269.1 - 0.077 12.8 0.4 0.2 11.4 0.3 1.7 1 1 0 1 1 1 0 Rap1 Myb domain Kelch_1 PF01344.20 ESA14269.1 - 0.12 11.8 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Kelch motif zf-CCHC PF00098.18 ESA14270.1 - 0.00029 20.5 6.8 0.0005 19.8 4.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.1 ESA14270.1 - 0.058 13.0 4.1 0.12 12.0 1.7 2.2 2 0 0 2 2 2 0 Zinc knuckle TPR_1 PF00515.23 ESA14271.1 - 0.0099 15.4 1.4 0.024 14.2 1.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA14271.1 - 0.023 14.6 0.3 0.033 14.1 0.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA14271.1 - 0.078 12.9 1.2 0.16 11.9 0.8 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat IF3_N PF05198.11 ESA14271.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain F-box-like PF12937.2 ESA14271.1 - 0.094 12.4 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 F-box-like LEA_4 PF02987.11 ESA14271.1 - 0.18 11.7 4.4 0.44 10.4 3.1 1.6 1 1 0 1 1 1 0 Late embryogenesis abundant protein Sel1 PF08238.7 ESA14275.1 - 5.6e-55 182.5 35.0 6.1e-11 42.5 0.6 7.5 7 0 0 7 7 7 7 Sel1 repeat STE PF02200.11 ESA14275.1 - 0.026 14.6 2.6 0.031 14.4 0.2 2.3 2 0 0 2 2 2 0 STE like transcription factor Ribosomal_S27 PF01599.14 ESA14275.1 - 0.072 12.9 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Ribosomal protein S27a CaKB PF03185.10 ESA14275.1 - 0.14 11.4 0.7 0.28 10.5 0.5 1.4 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit Pkinase_Tyr PF07714.12 ESA14276.1 - 1.7e-59 201.0 0.0 3.1e-33 114.9 0.0 4.1 3 1 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA14276.1 - 1.7e-52 178.1 0.3 2.9e-35 121.6 0.0 4.5 4 0 0 4 4 4 3 Protein kinase domain PsbU PF06514.6 ESA14276.1 - 0.0014 18.4 0.2 1.8 8.4 0.0 2.8 2 0 0 2 2 2 2 Photosystem II 12 kDa extrinsic protein (PsbU) Usg PF06233.7 ESA14276.1 - 0.0076 16.0 0.1 3 7.7 0.0 2.9 3 0 0 3 3 3 1 Usg-like family DUF2296 PF10058.4 ESA14276.1 - 0.015 15.0 2.2 4.3 7.1 0.1 4.4 4 0 0 4 4 4 0 Predicted integral membrane metal-binding protein (DUF2296) DZR PF12773.2 ESA14276.1 - 0.63 9.9 8.2 6.9 6.5 1.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon COX14 PF14880.1 ESA14277.1 - 1.4 8.5 3.9 33 4.1 0.4 3.2 3 0 0 3 3 3 0 Cytochrome oxidase c assembly DUF4131 PF13567.1 ESA14277.1 - 2.4 7.5 15.1 0.34 10.3 0.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Nucleo_P87 PF07267.6 ESA14279.1 - 0.063 11.9 4.9 0.017 13.8 1.5 1.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 Phage_int_SAM_3 PF14659.1 ESA14281.1 - 0.07 13.4 0.4 4.2 7.7 0.1 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain CUE PF02845.11 ESA14282.1 - 7.8e-11 41.2 2.1 0.00026 20.4 0.2 2.7 2 0 0 2 2 2 2 CUE domain DUF1771 PF08590.5 ESA14282.1 - 3.8e-10 39.6 2.7 8.2e-10 38.5 1.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.16 ESA14282.1 - 0.025 14.7 0.0 0.061 13.5 0.0 1.6 1 0 0 1 1 1 0 Smr domain UBA PF00627.26 ESA14282.1 - 0.11 12.4 0.2 15 5.5 0.0 2.4 2 0 0 2 2 2 0 UBA/TS-N domain Smr PF01713.16 ESA14283.1 - 1.4e-07 31.6 0.0 1.5e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Smr domain Pyridoxal_deC PF00282.14 ESA14286.1 - 0.042 12.2 0.1 0.042 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain CDC27 PF09507.5 ESA14287.1 - 2.7e-49 168.5 61.6 1.3e-48 166.3 42.7 1.8 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Nup96 PF12110.3 ESA14288.1 - 4.3e-64 216.4 5.9 8.6e-64 215.4 4.1 1.5 1 0 0 1 1 1 1 Nuclear protein 96 Sec16_C PF12931.2 ESA14288.1 - 0.005 16.6 0.1 0.0081 15.9 0.1 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Pkinase_Tyr PF07714.12 ESA14289.1 - 1.6e-10 40.4 0.0 0.00044 19.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase BCS1_N PF08740.6 ESA14289.1 - 4.6e-05 23.1 0.0 0.011 15.4 0.0 2.2 2 0 0 2 2 2 2 BCS1 N terminal DUF4413 PF14372.1 ESA14289.1 - 0.01 15.8 6.4 1 9.3 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) DUF2024 PF09630.5 ESA14289.1 - 0.22 11.2 6.8 5 6.9 0.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF2024) DnaJ_CXXCXGXG PF00684.14 ESA14289.1 - 0.85 9.7 16.7 1.4 9.0 0.8 3.4 3 0 0 3 3 3 0 DnaJ central domain Ribosomal_L37e PF01907.14 ESA14289.1 - 3.2 7.6 19.7 1.2 8.9 2.1 3.4 3 0 0 3 3 3 0 Ribosomal protein L37e DUF2806 PF10987.3 ESA14290.1 - 0.035 13.5 0.1 0.039 13.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) Pkinase PF00069.20 ESA14291.1 - 1.6e-22 79.9 1.3 2.3e-22 79.4 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14291.1 - 8.8e-20 70.8 0.0 1.2e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF970 PF06153.6 ESA14291.1 - 0.07 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF970) Cwf_Cwc_15 PF04889.7 ESA14293.1 - 0.068 12.8 8.6 0.068 12.8 6.0 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nodulin_late PF07127.6 ESA14294.1 - 0.05 13.7 1.7 0.059 13.4 0.2 1.9 2 0 0 2 2 2 0 Late nodulin protein DUF2457 PF10446.4 ESA14295.1 - 0.18 10.4 17.8 0.24 10.1 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Antimicrobial14 PF08109.6 ESA14296.1 - 2 8.3 5.7 3.8 7.4 0.0 3.0 2 1 0 2 2 2 0 Lactocin 705 family Sel1 PF08238.7 ESA14297.1 - 0.00036 21.0 0.1 0.00084 19.9 0.0 1.6 2 0 0 2 2 2 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA14297.1 - 0.00067 19.4 2.4 0.00087 19.0 1.7 1.3 1 1 0 1 1 1 1 zinc-ribbons DUF2616 PF11077.3 ESA14297.1 - 0.025 14.0 4.5 0.024 14.1 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) PocR PF10114.4 ESA14297.1 - 0.065 12.3 2.5 0.076 12.1 1.7 1.1 1 0 0 1 1 1 0 Sensory domain found in PocR TPR_6 PF13174.1 ESA14297.1 - 0.12 12.8 0.0 0.32 11.5 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA14297.1 - 0.13 12.4 0.1 0.3 11.3 0.1 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat Stc1 PF12898.2 ESA14297.1 - 0.19 11.7 6.3 0.29 11.2 4.1 1.6 1 1 0 1 1 1 0 Stc1 domain zf-C4_ClpX PF06689.8 ESA14297.1 - 2.9 7.4 6.0 1.3 8.6 0.2 2.4 3 0 0 3 3 3 0 ClpX C4-type zinc finger F-box-like PF12937.2 ESA14300.1 - 0.00053 19.6 1.6 0.00053 19.6 1.1 1.7 2 0 0 2 2 2 1 F-box-like Med24_N PF11277.3 ESA14300.1 - 0.013 13.0 0.0 0.016 12.7 0.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Pkinase_Tyr PF07714.12 ESA14301.1 - 5.9e-09 35.3 0.0 1.3e-07 30.9 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14301.1 - 6.1e-06 25.5 0.1 0.11 11.6 0.0 3.0 2 1 0 2 2 2 2 Protein kinase domain GIDA PF01134.17 ESA14304.1 - 0.97 8.2 4.7 0.24 10.1 1.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Kelch_3 PF13415.1 ESA14305.1 - 6.3e-11 42.1 12.0 0.018 15.2 0.0 5.6 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA14305.1 - 2.5e-09 36.7 12.8 0.084 12.6 0.6 5.0 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA14305.1 - 4.1e-07 29.9 13.9 0.0038 17.3 0.2 5.2 4 1 1 5 5 5 3 Kelch motif Kelch_5 PF13854.1 ESA14305.1 - 1.7e-06 27.8 13.2 0.12 12.3 0.3 5.6 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.10 ESA14305.1 - 0.0012 18.4 4.1 2.7 7.8 0.1 4.7 5 0 0 5 5 5 2 Kelch motif VASP_tetra PF08776.6 ESA14305.1 - 0.46 9.8 3.3 0.95 8.8 1.1 2.3 1 1 1 2 2 2 0 VASP tetramerisation domain Kelch_1 PF01344.20 ESA14305.1 - 1.6 8.3 14.7 0.27 10.7 0.2 4.1 4 0 0 4 4 4 0 Kelch motif PH PF00169.24 ESA14306.1 - 1.6e-14 53.9 1.9 3.6e-14 52.8 0.2 2.4 2 0 0 2 2 2 1 PH domain SH3_9 PF14604.1 ESA14306.1 - 4.6e-12 45.3 0.0 8.9e-12 44.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 ESA14306.1 - 5.7e-12 44.8 0.8 1.7e-11 43.3 0.1 2.1 2 0 0 2 2 2 1 SH3 domain SAM_2 PF07647.12 ESA14306.1 - 1.2e-11 44.2 0.1 2.6e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA14306.1 - 2.2e-09 37.3 0.1 4.2e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.12 ESA14306.1 - 8.3e-07 28.4 0.0 1.8e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.1 ESA14306.1 - 2.3e-06 27.7 1.0 9e-06 25.9 0.7 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain SAM_PNT PF02198.11 ESA14306.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Ste50p-SAM PF09235.5 ESA14306.1 - 0.074 13.0 0.9 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Ste50p, sterile alpha motif PH_9 PF15410.1 ESA14306.1 - 0.082 13.0 0.6 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain YGGT PF02325.12 ESA14306.1 - 0.19 11.7 1.8 8.2 6.4 0.1 2.4 1 1 1 2 2 2 0 YGGT family KH_1 PF00013.24 ESA14307.1 - 0.034 13.7 0.0 0.093 12.3 0.0 1.8 1 0 0 1 1 1 0 KH domain D-ser_dehydrat PF14031.1 ESA14307.1 - 0.14 12.3 0.2 1.1 9.4 0.0 2.2 2 0 0 2 2 2 0 Putative serine dehydratase domain Kelch_3 PF13415.1 ESA14309.1 - 2e-12 46.9 4.9 9e-05 22.5 0.2 5.2 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA14309.1 - 4.4e-10 39.1 11.3 0.0031 17.2 1.1 5.2 4 2 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA14309.1 - 5.8e-10 38.8 0.6 0.00032 20.5 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA14309.1 - 3.2e-09 36.5 11.2 0.0014 18.7 0.1 5.1 3 1 2 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA14309.1 - 1.4e-07 30.9 14.3 1.1e-05 24.8 0.1 4.8 5 1 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 ESA14309.1 - 0.00067 19.3 7.1 0.0018 17.9 0.1 3.9 4 1 0 4 4 4 1 Kelch motif BTB PF00651.26 ESA14312.1 - 1.4e-17 63.6 0.2 3e-17 62.6 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA14312.1 - 6.6e-11 41.9 3.0 6.9e-08 32.2 0.3 3.3 3 1 0 3 3 3 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA14312.1 - 0.042 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain RPM2 PF08579.6 ESA14312.1 - 0.12 12.5 1.9 0.58 10.3 0.0 2.8 2 2 1 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) BTB PF00651.26 ESA14313.1 - 1.6e-19 69.8 0.2 3.9e-19 68.6 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA14313.1 - 2.2e-09 37.0 4.8 1e-07 31.7 0.6 3.7 3 1 1 4 4 4 1 BTB And C-terminal Kelch Cupin_4 PF08007.7 ESA14313.1 - 0.0069 15.6 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 Cupin superfamily protein DUF3342 PF11822.3 ESA14313.1 - 0.042 12.9 0.7 0.076 12.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) JmjN PF02375.12 ESA14314.1 - 0.022 14.2 0.2 0.78 9.3 0.1 2.5 2 0 0 2 2 2 0 jmjN domain DUF1351 PF07083.6 ESA14314.1 - 0.054 13.1 0.4 0.062 12.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) LURAP PF14854.1 ESA14314.1 - 0.14 11.8 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Leucine rich adaptor protein Conotoxin PF02950.12 ESA14315.1 - 1.2 9.9 11.3 2.5e+02 2.5 7.8 2.7 1 1 0 1 1 1 0 Conotoxin FOP_dimer PF09398.5 ESA14316.1 - 0.1 12.6 2.2 0.38 10.7 0.1 2.5 1 1 1 2 2 2 0 FOP N terminal dimerisation domain Pkinase PF00069.20 ESA14317.1 - 0.077 12.1 0.0 0.49 9.4 0.0 2.1 1 1 1 2 2 2 0 Protein kinase domain Cys_Met_Meta_PP PF01053.15 ESA14319.1 - 6.5e-15 54.3 0.0 3.9e-14 51.7 0.0 1.9 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Bac_export_2 PF01312.14 ESA14320.1 - 0.68 8.7 3.4 0.9 8.3 2.3 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Carn_acyltransf PF00755.15 ESA14323.1 - 2.4e-175 584.0 0.0 2.7e-175 583.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase PGP_phosphatase PF09419.5 ESA14324.1 - 0.024 14.0 0.1 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase SWIRM PF04433.12 ESA14325.1 - 1.8e-35 120.8 0.5 4.9e-35 119.5 0.1 2.0 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-bind_6 PF13921.1 ESA14325.1 - 6.9e-10 38.8 0.1 3.5e-08 33.4 0.0 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.12 ESA14325.1 - 1.1e-09 37.6 3.0 2.2e-09 36.7 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 ESA14325.1 - 1e-08 35.0 0.4 3.4e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Dimer_Tnp_hAT PF05699.9 ESA14326.1 - 3.2e-18 65.1 0.1 3.7e-18 64.9 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ESA14327.1 - 6.8e-40 136.7 0.0 9.1e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14327.1 - 3.1e-37 128.1 0.1 4e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA14327.1 - 0.034 13.8 0.1 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA14328.1 - 3e-41 141.2 0.0 3.3e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14328.1 - 7.2e-38 130.2 0.1 7.9e-38 130.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA14328.1 - 0.018 14.8 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA14328.1 - 0.043 12.8 0.0 0.062 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Zn_clus PF00172.13 ESA14332.1 - 0.00013 21.7 10.5 0.00031 20.5 7.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF972 PF06156.8 ESA14332.1 - 0.047 14.0 3.1 0.094 13.0 2.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) L71 PF02448.10 ESA14332.1 - 0.076 12.8 10.2 0.24 11.2 0.3 2.5 2 0 0 2 2 2 0 L71 family COG2 PF06148.6 ESA14332.1 - 0.21 11.4 3.1 0.37 10.6 2.1 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DASH_Duo1 PF08651.5 ESA14332.1 - 0.56 9.8 4.2 0.29 10.7 0.9 1.9 2 0 0 2 2 2 0 DASH complex subunit Duo1 ATP-gua_PtransN PF02807.10 ESA14333.1 - 0.36 11.0 2.4 0.45 10.6 0.4 2.1 2 0 0 2 2 2 0 ATP:guanido phosphotransferase, N-terminal domain Pkinase_Tyr PF07714.12 ESA14334.1 - 0.024 13.7 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase MutH PF02976.10 ESA14334.1 - 0.035 13.9 0.3 0.053 13.3 0.2 1.4 1 0 0 1 1 1 0 DNA mismatch repair enzyme MutH HTH_33 PF13592.1 ESA14334.1 - 0.087 12.3 0.1 0.36 10.4 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix HMG_box PF00505.14 ESA14335.1 - 3.2e-08 33.7 0.0 8.5e-08 32.3 0.0 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box NUDIX PF00293.23 ESA14337.1 - 5.3e-12 45.5 0.0 6.2e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Scm3 PF10384.4 ESA14338.1 - 2.9e-12 45.8 0.2 1.1e-11 43.9 0.1 2.0 1 0 0 1 1 1 1 Centromere protein Scm3 Aldedh PF00171.17 ESA14340.1 - 1.7e-134 448.6 0.0 2e-134 448.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 ESA14340.1 - 7.8e-08 31.4 0.0 1.4e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) tRNA_edit PF04073.10 ESA14342.1 - 4.3e-21 75.0 0.0 6.1e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DEAD PF00270.24 ESA14343.1 - 5.6e-16 58.4 0.0 8.6e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA14343.1 - 1.5e-07 31.4 0.2 3.9e-07 30.0 0.1 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Kdo PF06293.9 ESA14343.1 - 0.016 14.2 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DivIC PF04977.10 ESA14345.1 - 0.00037 19.9 2.0 0.00037 19.9 1.4 1.9 2 0 0 2 2 2 1 Septum formation initiator HLH PF00010.21 ESA14345.1 - 0.0042 16.7 0.4 0.037 13.7 0.0 2.4 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain TMF_DNA_bd PF12329.3 ESA14345.1 - 0.25 11.1 9.0 0.21 11.4 1.7 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Wbp11 PF09429.5 ESA14345.1 - 2.1 8.4 6.7 0.55 10.2 1.9 2.0 2 0 0 2 2 2 0 WW domain binding protein 11 DUF904 PF06005.7 ESA14345.1 - 2.7 8.3 10.3 0.65 10.3 2.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF904) bZIP_1 PF00170.16 ESA14345.1 - 6.1 6.8 8.3 2 8.4 1.4 2.5 2 0 0 2 2 2 0 bZIP transcription factor HAP1_N PF04849.8 ESA14348.1 - 0.0022 16.9 3.1 0.0026 16.7 2.1 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Phlebovirus_NSM PF07246.6 ESA14348.1 - 0.011 14.8 4.7 0.014 14.5 3.1 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ADIP PF11559.3 ESA14348.1 - 0.032 14.1 2.5 0.044 13.6 1.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.6 ESA14348.1 - 0.044 13.4 1.0 0.2 11.4 0.7 2.1 1 1 0 1 1 1 0 Shugoshin N-terminal coiled-coil region IncA PF04156.9 ESA14348.1 - 0.046 13.3 5.5 0.27 10.7 3.4 2.0 1 1 1 2 2 2 0 IncA protein bZIP_1 PF00170.16 ESA14348.1 - 0.099 12.6 8.0 0.043 13.7 2.9 2.5 2 1 0 2 2 2 0 bZIP transcription factor DivIC PF04977.10 ESA14348.1 - 0.11 12.0 3.6 0.27 10.7 2.5 1.7 1 0 0 1 1 1 0 Septum formation initiator TSC22 PF01166.13 ESA14348.1 - 0.3 11.0 4.6 0.19 11.6 0.9 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF972 PF06156.8 ESA14348.1 - 0.86 9.9 5.3 3.5 8.0 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Lge1 PF11488.3 ESA14348.1 - 0.92 9.7 5.1 2.6 8.2 2.3 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF904 PF06005.7 ESA14348.1 - 1.1 9.6 8.6 1.9 8.8 3.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF904) bZIP_2 PF07716.10 ESA14348.1 - 2.5 7.9 10.9 0.08 12.7 1.9 2.6 2 2 0 2 2 2 0 Basic region leucine zipper Osmo_CC PF08946.5 ESA14348.1 - 3.4 7.7 7.4 9 6.4 3.4 2.3 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DUF2205 PF10224.4 ESA14348.1 - 6.9 6.3 9.3 2.7 7.6 3.7 2.1 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) SUKH-3 PF14433.1 ESA14349.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 SUKH-3 immunity protein Pkinase_Tyr PF07714.12 ESA14350.1 - 0.021 13.9 0.0 0.048 12.7 0.0 1.6 1 1 0 1 1 1 0 Protein tyrosine kinase RecR PF02132.10 ESA14350.1 - 0.084 12.3 0.6 0.13 11.6 0.4 1.3 1 0 0 1 1 1 0 RecR protein Tetraspannin PF00335.15 ESA14354.1 - 6.6e-06 25.5 12.5 6.6e-06 25.5 8.6 2.5 2 1 0 2 2 2 1 Tetraspanin family AF1Q PF15017.1 ESA14354.1 - 0.06 13.2 1.0 0.11 12.4 0.7 1.4 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator DUF4231 PF14015.1 ESA14354.1 - 7.9 6.5 6.7 7.3 6.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) TFCD_C PF12612.3 ESA14357.1 - 0.057 12.8 1.3 0.16 11.3 0.5 2.0 1 1 1 2 2 2 0 Tubulin folding cofactor D C terminal TLD PF07534.11 ESA14358.1 - 0.00019 21.4 0.3 0.00059 19.8 0.2 1.8 1 1 0 1 1 1 1 TLD Pkinase_Tyr PF07714.12 ESA14359.1 - 1.3e-47 162.1 0.0 1.9e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14359.1 - 3.4e-43 147.6 2.1 1.3e-42 145.7 1.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Glyoxal_oxid_N PF07250.6 ESA14360.1 - 3.9e-59 199.6 0.0 1.5e-56 191.2 0.0 3.1 2 2 1 3 3 3 2 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ESA14360.1 - 1.6e-15 56.9 0.4 3.4e-15 55.9 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.10 ESA14360.1 - 0.0047 16.6 0.9 0.12 12.1 0.0 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.1 ESA14360.1 - 0.017 14.8 4.4 3.5 7.4 0.0 4.0 3 1 1 4 4 4 0 Galactose oxidase, central domain Dimer_Tnp_hAT PF05699.9 ESA14362.1 - 5.8e-10 38.6 0.7 1.4e-09 37.4 0.5 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase PF00069.20 ESA14363.1 - 1.9e-42 145.2 0.2 2.3e-42 144.9 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14363.1 - 2.1e-41 141.7 0.0 2.5e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA14363.1 - 0.00016 21.5 0.0 0.14 11.8 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA14363.1 - 0.00091 18.6 0.4 0.0021 17.4 0.3 1.6 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA14363.1 - 0.00099 18.5 0.2 0.0017 17.7 0.1 1.4 1 1 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA14363.1 - 0.0066 15.6 0.7 0.012 14.8 0.5 1.4 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA14363.1 - 0.01 14.8 0.1 0.016 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Dabb PF07876.7 ESA14363.1 - 0.023 15.1 0.1 0.046 14.1 0.1 1.5 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain Choline_kinase PF01633.15 ESA14363.1 - 0.091 12.3 1.9 0.15 11.5 1.3 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 ESA14364.1 - 3.9e-37 127.7 0.0 5.4e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14364.1 - 2e-33 115.6 0.1 2.9e-33 115.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA14364.1 - 6.2e-11 42.5 4.0 0.0016 18.9 0.0 4.7 4 1 0 4 4 4 2 Sel1 repeat TPR_19 PF14559.1 ESA14364.1 - 0.042 14.1 0.1 0.12 12.6 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Hexokinase_2 PF03727.11 ESA14365.1 - 1.3e-77 260.2 0.0 2.4e-77 259.4 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 ESA14365.1 - 2.5e-74 249.0 0.2 3.7e-74 248.5 0.2 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.16 ESA14365.1 - 0.041 13.1 0.0 0.089 12.0 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Ldh_2 PF02615.9 ESA14365.1 - 0.049 12.3 0.0 0.12 11.1 0.0 1.5 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase FAM176 PF14851.1 ESA14366.1 - 0.1 12.2 0.5 0.1 12.2 0.4 1.5 1 1 1 2 2 2 0 FAM176 family Borrelia_P83 PF05262.6 ESA14366.1 - 0.57 8.3 10.2 0.65 8.2 7.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein MFS_1 PF07690.11 ESA14367.1 - 1.7e-14 53.3 22.8 2.3e-14 52.8 15.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pkinase PF00069.20 ESA14370.1 - 4.6e-36 124.2 0.0 5.6e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14370.1 - 1.2e-13 50.7 0.0 1.7e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA14370.1 - 0.0021 17.8 0.0 1.1 8.9 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF2142 PF09913.4 ESA14371.1 - 0.11 11.0 0.9 0.12 10.9 0.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) p450 PF00067.17 ESA14373.1 - 3.5e-09 35.6 0.3 4.1e-09 35.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 BAT2_N PF07001.6 ESA14374.1 - 1.1 9.5 6.9 1.3 9.3 4.8 1.1 1 0 0 1 1 1 0 BAT2 N-terminus Dicty_REP PF05086.7 ESA14374.1 - 2.3 5.8 8.4 2.3 5.8 5.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Menin PF05053.8 ESA14374.1 - 3.8 5.5 5.0 4 5.4 3.4 1.0 1 0 0 1 1 1 0 Menin MGC-24 PF05283.6 ESA14374.1 - 7.5 6.3 13.3 8.3 6.1 9.2 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) Mucin PF01456.12 ESA14374.1 - 7.7 6.2 22.5 8.7 6.1 15.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Herpes_capsid PF06112.6 ESA14374.1 - 9.4 6.2 9.3 11 5.9 6.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein G-patch PF01585.18 ESA14375.1 - 3.5e-16 58.6 0.4 3.5e-16 58.6 0.3 2.2 3 0 0 3 3 3 1 G-patch domain RRM_5 PF13893.1 ESA14375.1 - 3.3e-06 26.8 0.0 1e-05 25.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA14375.1 - 0.00012 21.6 0.0 0.00029 20.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.2 ESA14375.1 - 0.0014 18.4 1.6 0.0022 17.7 0.1 2.2 2 0 0 2 2 2 1 DExH-box splicing factor binding site WASH-7_mid PF14744.1 ESA14375.1 - 0.063 12.1 0.4 0.092 11.5 0.2 1.1 1 0 0 1 1 1 0 WASH complex subunit 7 Ribosomal_S2 PF00318.15 ESA14376.1 - 1.2e-45 155.3 0.1 2e-23 82.7 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 IL3 PF02059.10 ESA14377.1 - 0.13 12.2 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Interleukin-3 Dimer_Tnp_hAT PF05699.9 ESA14381.1 - 0.0029 17.1 0.0 0.0061 16.1 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region tRNA-synt_1 PF00133.17 ESA14382.1 - 3.4e-07 28.6 0.1 0.013 13.5 0.0 3.1 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) Ycf15 PF10705.4 ESA14382.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Chloroplast protein precursor Ycf15 putative Cyclin PF08613.6 ESA14383.1 - 1e-16 61.6 0.2 3e-16 60.1 0.1 1.7 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESA14383.1 - 0.033 13.7 0.0 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Cyclin, N-terminal domain FAR1 PF03101.10 ESA14384.1 - 2.8e-08 34.1 1.6 5.4e-08 33.2 0.4 1.8 2 0 0 2 2 2 1 FAR1 DNA-binding domain Pkinase PF00069.20 ESA14385.1 - 1.8e-31 109.2 0.8 1.8e-31 109.2 0.5 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14385.1 - 1.1e-30 106.5 0.5 1.1e-30 106.5 0.4 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Sel1 PF08238.7 ESA14385.1 - 4e-09 36.8 4.5 1.4e-05 25.5 0.0 3.7 3 1 0 3 3 3 2 Sel1 repeat DUF1722 PF08349.6 ESA14385.1 - 0.067 13.0 1.0 0.18 11.6 0.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1722) ABC_tran PF00005.22 ESA14386.1 - 2.7e-48 163.7 0.0 1.1e-28 100.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 ESA14386.1 - 2.2e-44 151.9 40.6 3.5e-25 88.9 8.2 3.1 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 ESA14386.1 - 7.1e-08 31.9 7.6 0.00031 20.0 1.8 4.2 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain T2SE PF00437.15 ESA14386.1 - 7.6e-06 25.0 0.0 0.032 13.1 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.1 ESA14386.1 - 2.5e-05 23.7 0.0 0.19 11.1 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 ESA14386.1 - 0.0009 18.7 0.5 0.3 10.6 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.1 ESA14386.1 - 0.0015 18.8 9.9 0.051 13.9 0.1 3.9 5 0 0 5 5 4 2 AAA domain FtsK_SpoIIIE PF01580.13 ESA14386.1 - 0.0016 17.9 0.1 0.99 8.8 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.1 ESA14386.1 - 0.0019 18.3 2.2 0.27 11.3 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_17 PF13207.1 ESA14386.1 - 0.0023 18.7 0.6 1.2 9.9 0.5 3.2 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 ESA14386.1 - 0.003 17.0 1.1 3.4 7.0 0.0 3.2 3 0 0 3 3 3 1 AAA-like domain AAA_18 PF13238.1 ESA14386.1 - 0.0044 17.3 0.0 3.5 7.9 0.1 2.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA14386.1 - 0.0049 16.8 0.2 2.4 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.12 ESA14386.1 - 0.011 15.6 0.7 0.32 10.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 ResIII PF04851.10 ESA14386.1 - 0.011 15.6 0.0 7.3 6.3 0.0 2.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MobB PF03205.9 ESA14386.1 - 0.015 15.0 2.3 6.2 6.5 0.0 3.5 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 ESA14386.1 - 0.032 14.7 0.1 11 6.5 0.0 2.8 2 0 0 2 2 2 0 Miro-like protein DUF258 PF03193.11 ESA14386.1 - 0.036 13.2 0.1 2 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DEAD PF00270.24 ESA14386.1 - 0.037 13.5 0.6 3.8 6.9 0.0 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_33 PF13671.1 ESA14386.1 - 0.045 13.6 1.4 1.5 8.6 0.1 2.8 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.9 ESA14386.1 - 0.068 12.8 0.0 14 5.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 ESA14386.1 - 0.085 11.8 0.4 2.4 7.0 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 ESA14386.1 - 0.58 9.7 2.7 2.1 8.0 0.2 2.6 3 0 0 3 3 2 0 NACHT domain Pkinase_Tyr PF07714.12 ESA14389.1 - 1.4e-31 109.5 0.0 1.5e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14389.1 - 5.2e-31 107.7 0.0 5.7e-31 107.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA14389.1 - 1.3e-05 24.3 0.1 1.5e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA14389.1 - 8.7e-05 22.3 0.1 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA14389.1 - 0.0018 17.6 0.2 0.0021 17.4 0.1 1.1 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA14389.1 - 0.0048 16.1 0.1 0.0059 15.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA14389.1 - 0.023 14.0 0.1 0.029 13.6 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_Tyr PF07714.12 ESA14391.1 - 3.7e-15 55.6 0.1 4.2e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14391.1 - 9.6e-11 41.3 0.0 1.2e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pribosyltran PF00156.22 ESA14392.1 - 9.2e-06 25.4 0.0 3.1e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 ESA14392.1 - 0.0038 16.5 0.0 0.95 8.7 0.0 2.1 2 0 0 2 2 2 2 Phosphoribosyl transferase Peripla_BP_4 PF13407.1 ESA14392.1 - 0.0092 15.3 0.1 0.18 11.1 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein domain UPRTase PF14681.1 ESA14392.1 - 0.12 11.6 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase WH1 PF00568.18 ESA14394.1 - 8.1e-29 99.5 0.2 1.1e-28 99.1 0.1 1.1 1 0 0 1 1 1 1 WH1 domain PBD PF00786.23 ESA14394.1 - 8.4e-11 42.1 1.4 1.8e-10 41.1 0.1 2.1 2 0 0 2 2 2 1 P21-Rho-binding domain zf-C2H2_4 PF13894.1 ESA14395.1 - 0.0003 20.8 2.8 0.15 12.4 0.5 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA14395.1 - 0.0067 16.6 5.8 0.57 10.6 0.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-RING_5 PF14634.1 ESA14396.1 - 1.2 8.8 7.4 0.12 12.0 0.8 2.2 2 0 0 2 2 2 0 zinc-RING finger domain Phage-scaffold PF09306.5 ESA14398.1 - 0.12 11.4 0.0 0.14 11.3 0.0 1.0 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein Pkinase_Tyr PF07714.12 ESA14399.1 - 1.1e-37 129.5 0.0 1.7e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14399.1 - 8e-35 120.2 0.0 1.3e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SPK PF04435.13 ESA14399.1 - 0.069 13.1 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF545) Pkinase_Tyr PF07714.12 ESA14400.1 - 1.4e-31 109.5 0.0 1.8e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14400.1 - 4.9e-30 104.5 0.1 7.3e-30 103.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA14400.1 - 0.0011 18.0 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family zf-HIT PF04438.11 ESA14400.1 - 0.089 12.4 3.8 0.16 11.5 2.6 1.4 1 0 0 1 1 1 0 HIT zinc finger Spindle_Spc25 PF08234.7 ESA14401.1 - 0.0083 16.1 0.7 0.096 12.7 0.0 2.0 1 1 1 2 2 2 1 Chromosome segregation protein Spc25 TaqI_C PF12950.2 ESA14401.1 - 0.036 13.7 0.3 0.046 13.4 0.2 1.1 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain F-box-like PF12937.2 ESA14402.1 - 3.4e-06 26.6 0.3 6.8e-06 25.7 0.2 1.5 1 0 0 1 1 1 1 F-box-like Rota_NSP4 PF01452.11 ESA14403.1 - 0.063 12.6 0.8 0.083 12.2 0.5 1.2 1 0 0 1 1 1 0 Rotavirus non structural protein LRR_4 PF12799.2 ESA14403.1 - 0.3 10.7 5.9 3.8 7.2 2.5 3.0 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA14404.1 - 0.00059 19.5 0.6 0.0018 17.9 0.4 1.9 1 0 0 1 1 1 1 F-box-like Peptidase_M22 PF00814.20 ESA14406.1 - 1.7e-48 165.4 0.2 1.7e-24 86.7 0.0 2.1 1 1 1 2 2 2 2 Glycoprotease family CDC14 PF08045.6 ESA14407.1 - 0.086 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 14, SIN component Neugrin PF06413.6 ESA14407.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Neugrin AMP-binding_C PF13193.1 ESA14408.1 - 1.6e-14 54.5 0.0 2e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain HTH_28 PF13518.1 ESA14409.1 - 0.00012 21.9 0.1 0.00015 21.6 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.1 ESA14409.1 - 0.00052 19.5 0.1 0.0012 18.3 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 ESA14409.1 - 0.0023 18.0 0.0 0.0025 17.9 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA14409.1 - 0.0031 17.1 0.0 0.0055 16.3 0.0 1.4 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 ESA14409.1 - 0.0035 17.0 0.2 0.0038 16.8 0.2 1.1 1 0 0 1 1 1 1 Transposase DUF2757 PF10955.3 ESA14409.1 - 0.064 13.4 0.1 0.4 10.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2757) GerE PF00196.14 ESA14409.1 - 0.086 12.1 0.1 0.46 9.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Pkinase_Tyr PF07714.12 ESA14410.1 - 3.5e-32 111.4 0.0 3.8e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14410.1 - 1.1e-31 109.9 0.3 1.2e-31 109.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA14410.1 - 0.00069 19.4 0.1 0.00084 19.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA14410.1 - 0.0042 16.3 0.0 0.0062 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA14410.1 - 0.016 14.3 0.0 0.019 14.0 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA14410.1 - 0.035 13.4 0.2 0.045 13.0 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Herpes_ori_bp PF02399.10 ESA14412.1 - 2.4e-12 45.7 0.4 3.3e-12 45.2 0.3 1.1 1 0 0 1 1 1 1 Origin of replication binding protein HMG_box PF00505.14 ESA14413.1 - 2.1e-09 37.4 0.0 3.6e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA14413.1 - 1.8e-06 28.1 0.0 2.2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain DUF4554 PF15091.1 ESA14414.1 - 0.079 11.6 0.1 0.089 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) PAGK PF15284.1 ESA14414.1 - 0.098 12.4 0.9 0.69 9.6 0.6 2.0 1 1 0 1 1 1 0 Phage-encoded virulence factor Dicty_REP PF05086.7 ESA14415.1 - 0.057 11.1 6.0 0.059 11.1 4.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Imm22 PF15592.1 ESA14415.1 - 0.061 13.6 1.2 0.096 13.0 0.8 1.5 1 1 0 1 1 1 0 Immunity protein 22 Phage_lambd_GpG PF06894.6 ESA14415.1 - 0.078 12.6 0.3 0.15 11.6 0.1 1.6 1 1 0 1 1 1 0 Bacteriophage lambda minor tail protein (GpG) LRR_8 PF13855.1 ESA14415.1 - 0.083 12.6 3.5 6.6 6.5 2.2 2.5 1 1 1 2 2 2 0 Leucine rich repeat LRR_4 PF12799.2 ESA14415.1 - 0.35 10.5 9.2 33 4.2 6.4 2.9 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) LUC7 PF03194.10 ESA14415.1 - 0.97 8.9 7.6 1.1 8.6 5.3 1.1 1 0 0 1 1 1 0 LUC7 N_terminus DUF4375 PF14300.1 ESA14415.1 - 1.5 8.8 5.8 5.7 6.9 4.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) THUMP PF02926.12 ESA14415.1 - 1.9 8.3 7.1 5.7 6.8 4.9 1.7 1 1 0 1 1 1 0 THUMP domain YihI PF04220.7 ESA14415.1 - 2.8 7.2 12.8 3.8 6.7 8.9 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) AHH PF14412.1 ESA14415.1 - 3.7 7.5 5.2 18 5.3 3.6 2.1 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH RRF_GI PF12614.3 ESA14415.1 - 5.9 6.7 8.7 2.5 7.9 2.0 2.0 1 1 1 2 2 2 0 Ribosome recycling factor Eaf7 PF07904.8 ESA14415.1 - 7.1 6.6 8.2 43 4.1 5.7 2.0 1 1 0 1 1 1 0 Chromatin modification-related protein EAF7 AAA_23 PF13476.1 ESA14415.1 - 9 6.5 19.4 11 6.2 13.5 1.1 1 0 0 1 1 1 0 AAA domain NPV_P10 PF05531.7 ESA14416.1 - 0.15 12.3 7.7 0.96 9.7 5.2 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.1 ESA14416.1 - 0.17 12.2 28.3 0.21 11.8 19.6 1.1 1 0 0 1 1 1 0 AAA domain tRNA-synt_His PF13393.1 ESA14416.1 - 0.29 10.1 6.0 0.33 9.9 4.1 1.2 1 0 0 1 1 1 0 Histidyl-tRNA synthetase Gasdermin PF04598.7 ESA14416.1 - 0.35 9.5 11.1 0.36 9.5 7.7 1.1 1 0 0 1 1 1 0 Gasdermin family Allexi_40kDa PF05549.6 ESA14416.1 - 0.97 8.6 6.7 1.1 8.4 4.6 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein V-ATPase_C PF03223.10 ESA14416.1 - 0.98 8.2 12.2 2.3 7.0 5.5 2.0 1 1 1 2 2 2 0 V-ATPase subunit C SidE PF12252.3 ESA14416.1 - 1.3 6.2 10.2 1.2 6.3 7.1 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein Ribosomal_S2 PF00318.15 ESA14416.1 - 3.8 6.6 8.4 4.3 6.5 5.6 1.4 1 1 0 1 1 1 0 Ribosomal protein S2 DUF4552 PF15089.1 ESA14417.1 - 0.0098 14.8 1.1 0.0098 14.8 0.7 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4552) Autophagy_act_C PF03987.10 ESA14418.1 - 0.096 12.8 0.3 0.13 12.4 0.2 1.4 1 1 0 1 1 1 0 Autophagocytosis associated protein, active-site domain DDE_1 PF03184.14 ESA14420.1 - 0.00011 21.3 0.1 0.073 12.2 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF853 PF05872.7 ESA14421.1 - 0.00044 18.7 0.0 0.00056 18.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.1 ESA14421.1 - 0.0005 20.3 0.0 0.00089 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA14421.1 - 0.00076 19.6 0.0 0.0017 18.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESA14421.1 - 0.0024 18.6 0.1 0.0047 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESA14421.1 - 0.0028 17.8 0.0 0.0045 17.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA14421.1 - 0.0098 14.9 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESA14421.1 - 0.019 14.9 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 ESA14421.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 ESA14421.1 - 0.025 13.4 0.0 0.063 12.1 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 ESA14421.1 - 0.053 13.5 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.21 ESA14421.1 - 0.072 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.22 ESA14421.1 - 0.13 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Somatostatin PF03002.10 ESA14421.1 - 1.8 8.3 4.6 4 7.1 3.2 1.6 1 0 0 1 1 1 0 Somatostatin/Cortistatin family Fijivirus_P9-2 PF06837.6 ESA14421.1 - 2 7.4 6.9 3.2 6.8 4.8 1.3 1 0 0 1 1 1 0 Fijivirus P9-2 protein NPV_P10 PF05531.7 ESA14422.1 - 0.18 12.0 3.9 0.26 11.5 2.6 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3571 PF12095.3 ESA14422.1 - 0.21 11.8 3.2 0.27 11.5 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3571) Synaptobrevin PF00957.16 ESA14422.1 - 1.1 8.8 4.9 1.5 8.4 1.3 2.1 1 1 1 2 2 2 0 Synaptobrevin DUF4375 PF14300.1 ESA14422.1 - 1.2 9.1 3.7 1.8 8.5 2.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) Orbi_VP5 PF00901.12 ESA14422.1 - 1.3 7.1 4.5 1.5 6.8 3.1 1.0 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 RRF_GI PF12614.3 ESA14422.1 - 1.8 8.3 4.8 3 7.6 3.1 1.5 1 1 0 1 1 1 0 Ribosome recycling factor DDE_3 PF13358.1 ESA14424.1 - 2.7e-10 40.1 0.0 3.2e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Tetraspannin PF00335.15 ESA14426.1 - 0.00015 21.1 0.3 0.00018 20.8 0.2 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4588 PF15251.1 ESA14426.1 - 0.055 13.4 4.6 0.076 12.9 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) CBM_19 PF03427.8 ESA14427.1 - 0.018 14.8 2.0 0.044 13.5 1.4 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) DNA_pol_B PF00136.16 ESA14428.1 - 0.0046 15.8 0.0 0.0073 15.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B Rpr2 PF04032.11 ESA14428.1 - 0.093 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain TFIID_20kDa PF03847.8 ESA14432.1 - 0.24 11.6 1.2 0.37 11.1 0.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A DUF908 PF06012.7 ESA14435.1 - 0.23 10.7 11.4 0.022 14.0 4.7 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) RR_TM4-6 PF06459.7 ESA14435.1 - 0.27 11.0 6.5 0.51 10.1 4.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.17 ESA14435.1 - 0.32 9.9 0.7 0.44 9.5 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.8 ESA14435.1 - 0.93 8.9 6.6 1 8.8 3.2 1.8 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DDHD PF02862.12 ESA14435.1 - 3.1 7.5 10.8 0.47 10.2 4.7 1.6 2 0 0 2 2 2 0 DDHD domain RNA_polI_A34 PF08208.6 ESA14435.1 - 3.8 7.1 25.8 0.59 9.7 14.7 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Cnd1_N PF12922.2 ESA14435.1 - 5.8 6.5 10.4 13 5.3 5.2 2.6 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Med19 PF10278.4 ESA14435.1 - 8.9 5.9 22.5 3.7 7.1 12.7 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 BTB PF00651.26 ESA14436.1 - 1e-18 67.3 0.1 2.1e-18 66.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14436.1 - 3.1e-11 43.0 4.2 1.8e-07 30.9 0.5 4.2 3 1 1 4 4 4 3 BTB And C-terminal Kelch Mito_fiss_reg PF05308.6 ESA14437.1 - 0.058 12.7 2.0 0.081 12.2 1.4 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator F-box PF00646.28 ESA14438.1 - 1e-07 31.3 0.1 2.7e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA14438.1 - 8.5e-07 28.6 0.2 2.2e-06 27.2 0.2 1.8 1 0 0 1 1 1 1 F-box-like BTB_2 PF02214.17 ESA14438.1 - 0.0074 16.4 0.1 0.017 15.3 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TryThrA_C PF12319.3 ESA14438.1 - 0.28 10.3 5.4 0.039 13.1 0.9 1.6 2 0 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal TPR_11 PF13414.1 ESA14439.1 - 1.8e-06 27.4 7.2 0.014 15.0 0.1 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESA14439.1 - 0.0015 18.2 11.9 0.041 13.8 0.8 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat zf-C3HC4_3 PF13920.1 ESA14439.1 - 0.0027 17.3 2.4 0.0058 16.2 1.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA14439.1 - 0.01 15.5 2.2 0.01 15.5 1.5 2.0 2 0 0 2 2 2 1 zinc-RING finger domain TPR_16 PF13432.1 ESA14439.1 - 0.016 15.8 0.2 1.2 9.9 0.4 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA14439.1 - 0.027 14.2 0.7 0.027 14.2 0.5 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TerY-C PF15616.1 ESA14439.1 - 0.055 13.4 0.2 0.12 12.3 0.2 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain TPR_12 PF13424.1 ESA14439.1 - 0.078 12.9 5.2 0.14 12.1 0.4 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA14439.1 - 0.089 13.1 0.3 0.25 11.7 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Rtf2 PF04641.7 ESA14439.1 - 0.17 11.0 5.6 0.3 10.2 3.8 1.6 1 1 0 1 1 1 0 Rtf2 RING-finger DUF2370 PF10176.4 ESA14441.1 - 0.002 17.5 0.1 0.002 17.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2370) CD34_antigen PF06365.7 ESA14441.1 - 0.0068 16.0 4.2 0.015 14.9 2.9 1.6 1 0 0 1 1 1 1 CD34/Podocalyxin family GRP PF07172.6 ESA14441.1 - 0.021 15.2 3.9 0.021 15.2 2.7 2.3 2 0 0 2 2 2 0 Glycine rich protein family DUF912 PF06024.7 ESA14441.1 - 0.024 14.6 1.0 0.024 14.6 0.7 3.3 3 1 1 4 4 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 ESA14441.1 - 0.037 12.2 0.0 0.053 11.7 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E gpUL132 PF11359.3 ESA14441.1 - 0.044 13.1 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycoprotein UL132 Peptidase_M56 PF05569.6 ESA14441.1 - 0.054 12.4 0.1 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 Neur_chan_memb PF02932.11 ESA14441.1 - 0.085 12.7 0.0 0.085 12.7 0.0 2.9 2 1 1 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Selenoprotein_S PF06936.6 ESA14441.1 - 0.29 10.6 3.0 0.34 10.4 0.2 2.0 1 1 1 2 2 2 0 Selenoprotein S (SelS) CcoS PF03597.10 ESA14441.1 - 0.54 9.7 6.6 0.04 13.3 1.0 1.7 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type Gag_p6 PF08705.6 ESA14441.1 - 1.7 8.7 9.2 0.22 11.5 0.4 2.7 2 0 0 2 2 2 0 Gag protein p6 DEAD PF00270.24 ESA14442.1 - 3.6e-47 159.9 0.0 5.9e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA14442.1 - 2.3e-28 97.8 0.0 5.6e-28 96.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA14442.1 - 0.0014 18.4 0.0 0.0078 16.0 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 ESA14442.1 - 0.0099 15.4 0.2 0.16 11.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain SecA_DEAD PF07517.9 ESA14442.1 - 0.026 13.8 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain Laminin_I PF06008.9 ESA14443.1 - 0.00087 18.6 6.0 0.0012 18.2 4.2 1.3 1 0 0 1 1 1 1 Laminin Domain I Spc7 PF08317.6 ESA14443.1 - 0.001 17.8 8.8 0.001 17.8 6.1 1.5 1 1 1 2 2 2 1 Spc7 kinetochore protein Med9 PF07544.8 ESA14443.1 - 0.0019 17.9 4.2 0.0019 17.9 2.9 3.0 1 1 2 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 Baculo_PEP_C PF04513.7 ESA14443.1 - 0.0071 16.1 4.0 0.024 14.4 1.6 2.3 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus HrpB7 PF09486.5 ESA14443.1 - 0.0073 16.2 7.3 0.085 12.7 5.2 2.0 1 1 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) PhoU PF01895.14 ESA14443.1 - 0.0083 16.5 2.5 0.0083 16.5 1.7 2.6 1 1 1 2 2 2 1 PhoU domain HAUS2 PF15003.1 ESA14443.1 - 0.0099 14.9 3.0 0.73 8.8 3.1 2.1 1 1 1 2 2 2 1 HAUS augmin-like complex subunit 2 IFT57 PF10498.4 ESA14443.1 - 0.013 14.3 6.8 0.031 13.0 1.9 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Peptidase_S46 PF10459.4 ESA14443.1 - 0.013 13.9 2.1 0.016 13.6 1.4 1.1 1 0 0 1 1 1 0 Peptidase S46 APG6 PF04111.7 ESA14443.1 - 0.014 14.5 5.5 0.018 14.0 3.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESA14443.1 - 0.017 13.0 2.9 0.019 12.8 2.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 ESA14443.1 - 0.021 13.2 7.5 0.028 12.9 5.2 1.1 1 0 0 1 1 1 0 AAA domain Cob_adeno_trans PF01923.13 ESA14443.1 - 0.026 14.2 4.1 0.078 12.7 0.6 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase SlyX PF04102.7 ESA14443.1 - 0.027 14.8 5.9 0.88 9.9 0.4 2.8 1 1 2 3 3 3 0 SlyX Golgin_A5 PF09787.4 ESA14443.1 - 0.029 12.9 9.3 0.039 12.4 6.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 WEMBL PF05701.6 ESA14443.1 - 0.036 12.5 9.8 0.041 12.3 6.8 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light IncA PF04156.9 ESA14443.1 - 0.036 13.6 15.9 0.026 14.1 6.5 1.9 1 1 1 2 2 2 0 IncA protein Prominin PF05478.6 ESA14443.1 - 0.048 11.1 2.6 0.051 11.1 1.8 1.1 1 0 0 1 1 1 0 Prominin NPV_P10 PF05531.7 ESA14443.1 - 0.052 13.7 5.2 1.5 9.0 2.1 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF445 PF04286.7 ESA14443.1 - 0.053 13.0 3.3 0.062 12.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF3435 PF11917.3 ESA14443.1 - 0.064 11.9 2.5 0.052 12.2 1.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3435) ADIP PF11559.3 ESA14443.1 - 0.076 12.9 10.7 2.8 7.8 5.8 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GLE1 PF07817.8 ESA14443.1 - 0.084 11.7 2.8 1.4 7.8 0.0 2.1 1 1 1 2 2 2 0 GLE1-like protein DivIC PF04977.10 ESA14443.1 - 0.088 12.3 14.7 0.19 11.2 0.2 3.3 1 1 2 3 3 3 0 Septum formation initiator RE_AlwI PF09491.5 ESA14443.1 - 0.098 11.1 5.7 0.11 10.9 3.9 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease Bacillus_HBL PF05791.6 ESA14443.1 - 0.1 11.9 6.8 0.19 11.0 3.9 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HhH-GPD PF00730.20 ESA14443.1 - 0.1 12.8 0.2 0.16 12.2 0.1 1.2 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein TSC22 PF01166.13 ESA14443.1 - 0.11 12.5 7.6 6 6.9 0.0 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family Cep57_MT_bd PF06657.8 ESA14443.1 - 0.13 12.2 10.6 2 8.3 0.6 3.0 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF1664 PF07889.7 ESA14443.1 - 0.14 12.0 6.4 2.1 8.1 1.5 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HAUS6_N PF14661.1 ESA14443.1 - 0.2 10.9 2.8 0.28 10.5 2.0 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF972 PF06156.8 ESA14443.1 - 0.21 11.9 8.5 0.19 12.0 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Reo_sigmaC PF04582.7 ESA14443.1 - 0.22 10.6 1.4 0.61 9.1 0.9 1.6 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.3 ESA14443.1 - 0.35 10.6 11.2 0.11 12.2 2.0 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.5 ESA14443.1 - 0.36 10.9 9.4 0.53 10.3 2.3 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.1 ESA14443.1 - 0.39 9.8 14.8 1.4 8.0 10.3 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.1 ESA14443.1 - 0.42 10.5 10.1 9 6.2 0.3 2.6 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion OmpH PF03938.9 ESA14443.1 - 0.43 10.5 4.6 0.67 9.8 3.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Cnl2_NKP2 PF09447.5 ESA14443.1 - 0.47 10.1 3.7 2.1 8.0 0.2 3.2 2 1 2 4 4 3 0 Cnl2/NKP2 family protein ATG16 PF08614.6 ESA14443.1 - 0.48 10.2 14.8 1.4 8.7 10.2 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Alb1 PF09135.6 ESA14443.1 - 0.71 10.5 8.0 1.5 9.4 5.6 1.6 1 1 0 1 1 1 0 Alb1 Myb_DNA-bind_4 PF13837.1 ESA14443.1 - 0.99 9.5 4.0 9.8 6.3 0.1 2.4 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Ran-binding PF05508.6 ESA14443.1 - 1 8.1 6.8 1.5 7.6 4.2 1.5 1 1 1 2 2 2 0 RanGTP-binding protein DUF4559 PF15112.1 ESA14443.1 - 1.1 8.3 7.6 1.4 8.0 3.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) CorA PF01544.13 ESA14443.1 - 1.2 8.1 13.4 4.1 6.3 8.8 2.0 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF3552 PF12072.3 ESA14443.1 - 1.2 8.3 15.9 0.38 9.9 6.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) FlxA PF14282.1 ESA14443.1 - 1.7 8.6 10.0 1.9 8.4 5.0 2.3 1 1 0 1 1 1 0 FlxA-like protein TPR_MLP1_2 PF07926.7 ESA14443.1 - 2 8.1 12.8 33 4.2 8.5 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein GrpE PF01025.14 ESA14443.1 - 2.1 7.8 8.9 34 3.9 6.2 2.7 1 1 0 1 1 1 0 GrpE DUF4140 PF13600.1 ESA14443.1 - 3.1 8.2 9.4 22 5.5 0.5 3.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) UPF0184 PF03670.8 ESA14443.1 - 3.5 7.8 7.2 39 4.5 0.1 3.8 1 1 2 4 4 4 0 Uncharacterised protein family (UPF0184) Lebercilin PF15619.1 ESA14443.1 - 3.8 6.8 17.5 37 3.6 11.5 2.1 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Ead_Ea22 PF13935.1 ESA14443.1 - 4.4 7.6 9.2 30 4.9 6.2 2.2 1 1 0 1 1 1 0 Ead/Ea22-like protein Atg14 PF10186.4 ESA14443.1 - 4.6 6.1 14.6 9.4 5.0 10.1 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ALMT PF11744.3 ESA14443.1 - 4.7 5.7 5.5 8.4 4.9 3.9 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter DUF724 PF05266.9 ESA14443.1 - 7.8 6.0 12.3 3.4 7.2 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Seryl_tRNA_N PF02403.17 ESA14443.1 - 7.9 6.5 13.9 5.7 7.0 3.0 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.8 ESA14443.1 - 8.4 5.3 6.8 8.3 5.3 1.0 1.7 1 1 1 2 2 2 0 TMPIT-like protein F-box-like PF12937.2 ESA14444.1 - 0.00061 19.4 0.4 0.0017 17.9 0.3 1.8 1 0 0 1 1 1 1 F-box-like Chs3p PF12271.3 ESA14445.1 - 1.7e-48 165.1 9.7 1.9e-48 164.9 6.7 1.0 1 0 0 1 1 1 1 Chitin synthase III catalytic subunit QueT PF06177.6 ESA14445.1 - 0.33 10.9 4.0 1 9.3 2.8 1.9 1 1 0 1 1 1 0 QueT transporter DUF2427 PF10348.4 ESA14445.1 - 0.35 10.4 2.3 0.51 9.9 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) DUF4199 PF13858.1 ESA14445.1 - 4 7.3 6.4 5.5 6.8 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) SASP PF00269.15 ESA14446.1 - 0.0091 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type DHC_N2 PF08393.8 ESA14447.1 - 0.004 15.7 0.1 0.0046 15.5 0.1 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 Spindle_Spc25 PF08234.7 ESA14447.1 - 0.04 13.9 0.1 0.068 13.1 0.1 1.4 1 1 0 1 1 1 0 Chromosome segregation protein Spc25 DUF4583 PF15190.1 ESA14448.1 - 0.13 11.8 1.4 0.16 11.6 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4583) Kelch_3 PF13415.1 ESA14449.1 - 9e-15 54.3 1.6 0.0092 16.1 0.0 5.5 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA14449.1 - 1.7e-14 53.2 16.9 0.0056 16.8 0.0 6.1 3 2 2 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA14449.1 - 7.7e-14 51.1 13.9 0.0005 19.7 0.0 5.8 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA14449.1 - 1.4e-11 44.0 15.1 0.019 14.8 0.3 6.3 5 2 2 7 7 7 5 Kelch motif Kelch_2 PF07646.10 ESA14449.1 - 9e-08 31.5 3.7 0.016 14.9 0.0 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 ESA14449.1 - 4.3e-05 22.9 15.2 0.00028 20.3 0.0 4.9 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.9 ESA14449.1 - 0.007 15.1 0.0 0.31 9.7 0.0 2.7 3 0 0 3 3 3 1 Recombination activating protein 2 BTB PF00651.26 ESA14450.1 - 5.5e-19 68.2 0.1 6.4e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA14450.1 - 0.036 13.1 0.0 0.042 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Kelch_5 PF13854.1 ESA14451.1 - 4.5e-21 74.3 11.1 0.015 15.1 1.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 ESA14451.1 - 3.2e-20 71.7 2.9 0.00049 20.1 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA14451.1 - 7.3e-20 70.4 9.9 0.00052 19.7 0.1 6.7 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA14451.1 - 1e-17 63.4 10.0 0.0011 19.0 0.3 6.3 5 1 1 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA14451.1 - 1.6e-16 59.3 5.4 0.00052 19.6 0.1 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 ESA14451.1 - 8.6e-12 44.4 11.7 0.0046 16.4 0.5 5.6 5 0 0 5 5 5 3 Kelch motif DUF1376 PF07120.6 ESA14452.1 - 0.086 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) LRR_9 PF14580.1 ESA14454.1 - 6.3e-63 211.4 0.6 8.1e-63 211.1 0.4 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 ESA14454.1 - 1.1e-13 50.6 4.8 2.2e-12 46.5 0.9 3.4 3 0 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.2 ESA14454.1 - 2.2e-13 49.4 20.0 4.6e-09 35.7 2.5 4.0 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA14454.1 - 4.9e-06 25.8 8.9 1.3 9.3 0.6 5.5 4 1 1 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 ESA14454.1 - 0.0048 16.8 5.4 32 5.3 1.8 4.7 3 1 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 ESA14454.1 - 0.011 15.7 6.7 1.4 9.2 0.5 4.6 4 1 0 4 4 4 0 Leucine Rich repeat Arylesterase PF01731.15 ESA14455.1 - 5.8e-10 39.0 0.0 1.8e-09 37.4 0.0 1.9 1 0 0 1 1 1 1 Arylesterase SGL PF08450.7 ESA14455.1 - 1.9e-06 27.4 0.1 2.9e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Metallophos PF00149.23 ESA14456.1 - 2e-40 138.3 0.1 3.2e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LRR_4 PF12799.2 ESA14458.1 - 0.003 17.1 5.8 0.023 14.3 0.3 3.4 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA14458.1 - 0.0043 16.7 0.3 0.0043 16.7 0.2 2.2 2 0 0 2 2 2 1 F-box-like Ubiq-assoc PF09145.5 ESA14458.1 - 0.03 14.1 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-associated EFP PF01132.15 ESA14460.1 - 0.028 14.0 0.0 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain Abhydro_lipase PF04083.11 ESA14461.1 - 4.1e-20 70.8 0.3 1.2e-19 69.4 0.2 1.8 1 1 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 ESA14461.1 - 9.5e-15 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA14461.1 - 8.2e-05 22.3 0.0 0.0003 20.5 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 ESA14461.1 - 0.081 12.3 0.0 0.35 10.2 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Podoplanin PF05808.6 ESA14462.1 - 0.0099 15.4 1.4 0.013 15.0 1.0 1.1 1 0 0 1 1 1 1 Podoplanin DUF3353 PF11833.3 ESA14462.1 - 1.4 8.3 6.9 1.6 8.1 4.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3353) Pkinase PF00069.20 ESA14463.1 - 0.034 13.3 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Peptidase_S31 PF05578.7 ESA14464.1 - 0.065 12.4 0.2 0.07 12.3 0.1 1.1 1 0 0 1 1 1 0 Pestivirus NS3 polyprotein peptidase S31 DUF4167 PF13763.1 ESA14464.1 - 0.1 12.6 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) US2 PF02476.10 ESA14466.1 - 0.087 13.3 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 US2 family CBM_20 PF00686.14 ESA14467.1 - 3.9e-05 23.1 0.0 0.00011 21.7 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain DUF2430 PF10353.4 ESA14467.1 - 0.015 15.4 0.8 3.6 7.8 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2430) Tape_meas_lam_C PF09718.5 ESA14470.1 - 0.04 13.8 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Phage_holin PF04688.8 ESA14471.1 - 0.1 12.1 0.2 2.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Phage lysis protein, holin DUF1542 PF07564.6 ESA14472.1 - 0.0033 17.4 0.6 0.0053 16.7 0.1 1.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA14472.1 - 0.01 15.6 0.2 0.015 15.1 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF148 Methyltransf_11 PF08241.7 ESA14474.1 - 3.5e-07 30.6 0.0 4.2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA14474.1 - 4.5e-06 26.3 0.0 9.4e-06 25.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA14474.1 - 0.0001 22.5 0.0 0.00013 22.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA14474.1 - 0.0028 17.3 0.0 0.003 17.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA14474.1 - 0.0042 16.2 0.0 0.0048 16.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA14474.1 - 0.031 14.8 0.0 0.083 13.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 ESA14474.1 - 0.098 13.1 0.0 0.18 12.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain AAA_7 PF12775.2 ESA14475.1 - 0.019 14.0 0.3 0.019 14.0 0.2 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region D3 UPF0139 PF03669.8 ESA14475.1 - 0.076 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) SAD_SRA PF02182.12 ESA14475.1 - 0.091 12.0 0.5 0.14 11.4 0.4 1.2 1 0 0 1 1 1 0 SAD/SRA domain E2R135 PF11570.3 ESA14476.1 - 0.16 12.0 1.3 0.35 10.9 0.3 2.0 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 BTB PF00651.26 ESA14478.1 - 2.4e-05 24.2 1.2 0.00036 20.4 0.1 2.5 2 1 0 2 2 2 1 BTB/POZ domain DASH_Ask1 PF08655.5 ESA14482.1 - 0.12 12.2 0.4 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 DASH complex subunit Ask1 DBD_Tnp_Mut PF03108.10 ESA14483.1 - 4.5e-05 22.9 0.2 0.00065 19.2 0.0 2.7 3 0 0 3 3 3 1 MuDR family transposase FAR1 PF03101.10 ESA14483.1 - 7.6e-05 23.1 0.1 0.00019 21.8 0.0 1.7 1 0 0 1 1 1 1 FAR1 DNA-binding domain Sec16_C PF12931.2 ESA14484.1 - 4.1e-77 259.7 0.0 6.4e-77 259.0 0.0 1.3 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 ESA14484.1 - 1.5e-21 76.5 0.0 3.9e-21 75.2 0.0 1.7 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DHBP_synthase PF00926.14 ESA14485.1 - 1.7e-85 285.1 0.0 2e-85 284.9 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase DUF2183 PF09949.4 ESA14485.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) Snf7 PF03357.16 ESA14486.1 - 1.1e-48 164.7 16.9 1.4e-48 164.4 11.7 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.7 ESA14486.1 - 0.002 18.3 13.2 0.15 12.3 3.4 3.2 2 1 0 2 2 2 2 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.15 ESA14486.1 - 0.0031 17.2 18.6 0.0073 16.0 0.0 3.5 2 1 0 3 3 3 1 Prefoldin subunit DUF3091 PF11291.3 ESA14486.1 - 0.021 14.7 5.6 0.029 14.3 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) Prefoldin PF02996.12 ESA14486.1 - 0.058 13.0 0.4 0.058 13.0 0.3 3.8 3 1 2 5 5 4 0 Prefoldin subunit NIT PF08376.5 ESA14486.1 - 0.06 12.8 3.9 0.072 12.5 2.0 1.7 1 1 0 1 1 1 0 Nitrate and nitrite sensing Peptidase_M13 PF01431.16 ESA14486.1 - 0.29 10.2 4.3 0.41 9.7 3.0 1.1 1 0 0 1 1 1 0 Peptidase family M13 Seryl_tRNA_N PF02403.17 ESA14486.1 - 0.51 10.3 18.7 1.5 8.8 5.8 2.9 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF4006 PF13179.1 ESA14486.1 - 0.54 9.8 3.6 0.22 11.0 0.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF4006) Mnd1 PF03962.10 ESA14486.1 - 0.62 9.6 14.2 38 3.8 9.9 2.2 1 1 0 1 1 1 0 Mnd1 family OmpH PF03938.9 ESA14486.1 - 0.66 9.8 19.9 0.23 11.4 5.4 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.6 ESA14486.1 - 1.1 9.2 10.8 0.79 9.6 0.2 3.4 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) SlyX PF04102.7 ESA14486.1 - 1.2 9.5 0.0 1.2 9.5 0.0 3.8 3 1 2 5 5 5 0 SlyX DUF4140 PF13600.1 ESA14486.1 - 1.7 9.1 9.7 1.3 9.4 0.1 3.4 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2730 PF10805.3 ESA14486.1 - 1.8 8.3 5.4 2.7 7.7 0.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) DUF972 PF06156.8 ESA14486.1 - 2.2 8.6 12.1 8.4 6.7 4.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) NuA4 PF09340.5 ESA14486.1 - 3.4 7.3 10.7 0.038 13.6 1.7 2.2 3 0 0 3 3 3 0 Histone acetyltransferase subunit NuA4 Sugarporin_N PF11471.3 ESA14486.1 - 3.6 7.3 7.2 1.1 8.9 0.0 2.8 3 0 0 3 3 2 0 Maltoporin periplasmic N-terminal extension EMP24_GP25L PF01105.19 ESA14486.1 - 5.5 6.6 9.6 1.5 8.4 0.2 2.5 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD GrpE PF01025.14 ESA14486.1 - 7.9 5.9 16.1 3.3 7.2 8.9 2.0 1 1 1 2 2 2 0 GrpE Homoserine_dh PF00742.14 ESA14487.1 - 1e-50 171.8 0.0 1.4e-50 171.4 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 ESA14487.1 - 1.6e-21 76.8 0.0 2.6e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.15 ESA14487.1 - 0.067 13.1 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 ESA14487.1 - 0.093 13.2 0.0 0.28 11.7 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold 6PF2K PF01591.13 ESA14487.1 - 0.095 11.7 0.0 0.27 10.2 0.0 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Semialdhyde_dh PF01118.19 ESA14487.1 - 0.11 12.8 0.1 0.48 10.7 0.1 2.1 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SUI1 PF01253.17 ESA14488.1 - 2.8e-20 71.9 0.1 7.3e-20 70.5 0.1 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 Bunya_nucleocap PF00952.12 ESA14488.1 - 0.22 11.4 1.6 1.3 9.0 0.2 2.1 1 1 1 2 2 2 0 Bunyavirus nucleocapsid (N) protein DNA_primase_S PF01896.14 ESA14489.1 - 3.6e-55 185.7 0.9 1.1e-54 184.1 0.3 1.9 1 1 0 2 2 2 1 Eukaryotic and archaeal DNA primase small subunit DUF4371 PF14291.1 ESA14491.1 - 2.5e-07 30.5 0.0 3.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.9 ESA14491.1 - 1.8e-05 24.2 0.0 4.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3903 PF13043.1 ESA14491.1 - 0.096 12.2 0.3 2.2 7.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3903) PGAP1 PF07819.8 ESA14492.1 - 5.2e-81 271.5 0.0 7.5e-81 270.9 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 ESA14492.1 - 0.00031 20.5 0.0 0.00065 19.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 ESA14492.1 - 0.00066 19.3 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 ESA14492.1 - 0.0021 18.0 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ESA14492.1 - 0.039 13.2 0.1 0.086 12.1 0.1 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Adaptin_N PF01602.15 ESA14493.1 - 5.1e-148 493.6 10.2 6.5e-148 493.3 7.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESA14493.1 - 7.1e-09 35.8 1.7 0.0077 16.4 0.0 3.8 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.17 ESA14493.1 - 0.003 17.4 4.2 43 4.5 0.0 6.2 6 0 0 6 6 6 0 HEAT repeat SDA1 PF05285.7 ESA14493.1 - 0.037 13.2 27.7 0.082 12.1 18.7 2.0 2 0 0 2 2 2 0 SDA1 Cnd1 PF12717.2 ESA14493.1 - 0.26 11.0 6.4 0.53 10.1 0.0 3.7 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Na_trans_assoc PF06512.8 ESA14493.1 - 6.1 6.7 21.1 17 5.2 14.6 1.7 1 0 0 1 1 1 0 Sodium ion transport-associated RNA_pol_N PF01194.12 ESA14494.1 - 1.4e-29 101.9 0.8 1.5e-29 101.7 0.5 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Sel1 PF08238.7 ESA14496.1 - 3.4e-57 189.6 36.7 2.2e-12 47.1 0.8 6.0 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA14496.1 - 1.1e-10 41.1 18.1 0.34 11.4 0.1 5.9 6 0 0 6 6 6 5 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA14496.1 - 1.6e-06 28.0 0.0 0.32 10.6 0.0 4.0 1 1 2 3 3 3 2 Caspase domain TPR_17 PF13431.1 ESA14496.1 - 1.3e-05 24.9 19.7 1.6 9.0 0.1 6.7 6 2 0 6 6 6 3 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA14496.1 - 0.00011 21.7 2.6 17 5.2 0.0 4.7 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation MIT PF04212.13 ESA14496.1 - 0.0009 19.0 21.5 1.8 8.5 0.1 5.1 5 0 0 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_20 PF14561.1 ESA14496.1 - 0.0012 18.8 0.3 0.38 10.9 0.0 3.6 1 1 5 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA14496.1 - 0.049 13.9 9.0 1.9 8.8 0.1 4.3 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA14496.1 - 0.053 13.4 21.6 0.31 10.9 2.4 4.5 1 1 4 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA14496.1 - 0.098 13.3 5.1 8.5 7.1 0.1 4.2 2 1 4 6 6 5 0 Tetratricopeptide repeat Recep_L_domain PF01030.19 ESA14496.1 - 0.27 11.2 1.3 25 4.8 0.0 2.7 2 1 1 3 3 3 0 Receptor L domain SnoaL_3 PF13474.1 ESA14496.1 - 1 9.3 4.0 2.4 8.1 0.3 3.0 3 1 1 4 4 4 0 SnoaL-like domain DUF3087 PF11286.3 ESA14496.1 - 1.5 8.0 7.4 17 4.6 0.1 3.9 2 1 3 5 5 5 0 Protein of unknown function (DUF3087) Apc3 PF12895.2 ESA14496.1 - 1.5 9.0 24.0 0.81 9.8 0.2 4.4 2 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Prenyltrans_1 PF13243.1 ESA14496.1 - 3.9 7.5 6.2 8.9 6.3 0.7 2.8 1 1 2 3 3 3 0 Prenyltransferase-like YpzG PF14139.1 ESA14497.1 - 0.099 12.5 0.5 0.35 10.8 0.3 1.8 1 1 0 1 1 1 0 YpzG-like protein DUF1978 PF09321.5 ESA14498.1 - 0.08 12.3 3.9 0.1 12.0 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) IMPDH PF00478.20 ESA14499.1 - 4.2e-139 463.3 1.1 5e-139 463.0 0.8 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 ESA14499.1 - 1.9e-17 62.7 0.0 1.2e-08 34.5 0.0 2.7 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 ESA14499.1 - 8.3e-11 41.6 8.4 1.9e-07 30.5 5.8 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 ESA14499.1 - 1.9e-09 36.8 0.8 4.1e-09 35.7 0.6 1.5 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 ESA14499.1 - 8.4e-09 35.0 3.3 5e-08 32.4 2.3 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 ESA14499.1 - 3.2e-05 23.1 4.5 5.2e-05 22.4 0.9 2.2 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.9 ESA14499.1 - 0.00011 21.2 2.5 0.0004 19.4 0.9 2.4 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.16 ESA14499.1 - 0.0007 18.6 4.5 0.0094 14.9 0.2 2.3 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Dus PF01207.12 ESA14499.1 - 0.00091 18.1 0.6 0.062 12.1 0.0 2.9 3 0 0 3 3 3 1 Dihydrouridine synthase (Dus) PcrB PF01884.12 ESA14499.1 - 0.011 15.0 5.0 0.53 9.4 0.2 3.8 3 1 0 4 4 4 0 PcrB family PK PF00224.16 ESA14499.1 - 0.013 14.1 0.2 0.039 12.5 0.0 1.8 2 0 0 2 2 2 0 Pyruvate kinase, barrel domain EAL PF00563.15 ESA14499.1 - 0.018 14.5 0.4 1.2 8.5 0.1 2.3 2 0 0 2 2 2 0 EAL domain DUF561 PF04481.7 ESA14499.1 - 0.086 11.7 0.5 0.47 9.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF561) Tat PF00539.13 ESA14500.1 - 0.13 11.8 2.1 0.28 10.8 1.5 1.4 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) BTB PF00651.26 ESA14501.1 - 5.9e-18 64.8 0.4 1.5e-17 63.5 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA14501.1 - 1e-05 25.3 0.3 6.2e-05 22.7 0.1 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA14501.1 - 5.8e-05 23.1 4.5 0.00013 21.9 3.1 1.7 1 0 0 1 1 1 1 TLD DUF3342 PF11822.3 ESA14501.1 - 0.014 14.5 0.3 0.023 13.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Sel1 PF08238.7 ESA14502.1 - 8.7e-65 213.7 20.8 2.9e-10 40.4 0.4 7.1 7 0 0 7 7 7 7 Sel1 repeat MIT PF04212.13 ESA14502.1 - 2.3e-05 24.1 16.3 0.033 14.0 0.2 5.1 5 1 0 5 5 5 3 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA14502.1 - 0.00033 20.7 1.2 19 5.4 0.0 4.5 1 1 3 4 4 4 2 Predicted AdoMet-dependent methyltransferase DUF4394 PF14339.1 ESA14502.1 - 0.89 8.7 5.0 11 5.2 0.1 3.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4394) EF-hand_10 PF14788.1 ESA14502.1 - 1.9 8.2 4.4 5.7 6.6 0.0 3.6 6 0 0 6 6 6 0 EF hand BTB PF00651.26 ESA14504.1 - 1.7e-10 40.8 0.0 1.9e-10 40.6 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain p450 PF00067.17 ESA14505.1 - 1.7e-38 132.3 0.0 1.9e-38 132.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA14507.1 - 2.1e-08 33.1 0.6 1.1e-05 24.2 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 RdRP PF05183.7 ESA14508.1 - 0.00066 18.4 0.0 0.00085 18.1 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF1410 PF07198.6 ESA14508.1 - 0.057 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) UBA_3 PF09288.5 ESA14509.1 - 0.66 9.6 2.8 0.57 9.8 0.3 2.1 1 1 1 2 2 2 0 Fungal ubiquitin-associated domain FHA PF00498.21 ESA14510.1 - 2.2e-16 59.7 0.1 2.6e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 FHA domain ERF PF04404.7 ESA14511.1 - 0.0024 17.3 0.2 0.0034 16.9 0.1 1.4 1 0 0 1 1 1 1 ERF superfamily Spectrin PF00435.16 ESA14511.1 - 0.06 13.6 0.2 0.091 13.0 0.2 1.3 1 0 0 1 1 1 0 Spectrin repeat DUF1510 PF07423.6 ESA14512.1 - 0.36 10.1 12.2 0.38 10.0 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) TRAP_alpha PF03896.11 ESA14512.1 - 0.37 9.7 5.8 0.39 9.6 4.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.3 ESA14512.1 - 0.96 7.9 4.9 1.1 7.8 3.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Daxx PF03344.10 ESA14512.1 - 1.1 7.6 9.6 1 7.7 6.7 1.1 1 0 0 1 1 1 0 Daxx Family Nop25 PF09805.4 ESA14512.1 - 1.2 9.1 8.1 1.6 8.8 5.6 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF2457 PF10446.4 ESA14512.1 - 1.3 7.7 16.5 1.6 7.3 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 ESA14512.1 - 1.4 6.7 10.4 1.3 6.8 7.2 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.5 ESA14512.1 - 1.4 7.8 11.4 1.5 7.8 7.9 1.0 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 ESA14512.1 - 2.3 6.1 9.3 2.1 6.2 6.5 1.0 1 0 0 1 1 1 0 CDC45-like protein FLO_LFY PF01698.11 ESA14512.1 - 2.4 6.9 6.3 2.6 6.7 4.4 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein Pox_Ag35 PF03286.9 ESA14512.1 - 3.5 7.1 11.4 3.6 7.0 7.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SNARE PF05739.14 ESA14515.1 - 2.2e-08 33.6 0.1 3.3e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.4 ESA14515.1 - 0.00047 19.6 0.0 0.00053 19.5 0.0 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Cas_TM1802 PF09484.5 ESA14515.1 - 0.028 12.9 0.0 0.031 12.7 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) DUF1664 PF07889.7 ESA14515.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ATG27 PF09451.5 ESA14515.1 - 0.15 11.3 0.9 0.18 11.0 0.6 1.3 1 1 0 1 1 1 0 Autophagy-related protein 27 DUF3753 PF12575.3 ESA14515.1 - 0.15 11.8 1.2 0.29 10.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) zf-MYND PF01753.13 ESA14516.1 - 1.6e-09 37.4 44.4 1.3e-08 34.5 11.2 3.5 3 0 0 3 3 3 2 MYND finger zf-Mss51 PF13824.1 ESA14516.1 - 0.00045 20.0 29.1 0.0018 18.0 4.8 3.3 3 0 0 3 3 3 2 Zinc-finger of mitochondrial splicing suppressor 51 His_Phos_2 PF00328.17 ESA14517.1 - 1e-15 57.9 0.0 1.2e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Phosphodiest PF01663.17 ESA14518.1 - 4.7e-13 49.2 1.0 5.6e-07 29.2 0.5 2.3 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 ESA14518.1 - 4.3e-07 29.4 0.0 1.3e-06 27.8 0.0 1.7 1 1 0 2 2 2 1 Sulfatase PRANC PF09372.5 ESA14518.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 PRANC domain Complex1_LYR_2 PF13233.1 ESA14519.1 - 4.3e-11 43.2 1.8 5.7e-11 42.8 1.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 ESA14519.1 - 9.6e-08 31.7 1.1 1.7e-07 30.9 0.7 1.5 1 1 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA14519.1 - 2.6e-05 24.3 1.5 3.9e-05 23.7 1.0 1.3 1 0 0 1 1 1 1 Complex1_LYR-like Sec23_helical PF04815.10 ESA14520.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Pkinase PF00069.20 ESA14521.1 - 6.6e-48 163.1 0.1 1e-47 162.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14521.1 - 8.1e-48 162.7 0.0 1e-47 162.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA14521.1 - 0.00016 20.9 0.1 0.00036 19.8 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA14521.1 - 0.0047 16.2 0.0 0.009 15.3 0.0 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA14521.1 - 0.0056 16.0 0.6 0.032 13.5 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA14521.1 - 0.0071 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA14521.1 - 0.0084 15.1 0.0 0.016 14.2 0.0 1.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA14521.1 - 0.086 12.5 0.1 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3965 PF13112.1 ESA14523.1 - 0.095 11.8 0.0 0.17 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3965) F-box-like PF12937.2 ESA14525.1 - 3.8e-05 23.3 0.1 0.00013 21.6 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA14525.1 - 0.0058 16.2 1.9 0.018 14.6 0.0 2.7 3 0 0 3 3 3 1 F-box domain Sel1 PF08238.7 ESA14526.1 - 1.7e-86 282.7 50.4 3.1e-12 46.6 0.8 8.6 9 0 0 9 9 9 8 Sel1 repeat MIT PF04212.13 ESA14526.1 - 8.2e-06 25.6 19.3 0.71 9.7 0.2 5.4 4 3 1 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA14526.1 - 7.1e-05 22.9 22.8 12 6.5 0.1 7.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA14526.1 - 0.00066 19.6 27.4 2.2 8.6 0.9 9.6 6 4 2 9 9 9 1 Tetratricopeptide repeat TPR_20 PF14561.1 ESA14526.1 - 0.00083 19.4 1.2 7.7 6.7 0.1 4.6 1 1 2 4 4 4 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA14526.1 - 0.0021 17.7 4.2 30 4.4 0.0 5.5 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation Peptidase_C14 PF00656.17 ESA14526.1 - 0.041 13.5 0.0 10 5.7 0.0 3.6 1 1 3 4 4 4 0 Caspase domain TPR_12 PF13424.1 ESA14526.1 - 0.21 11.5 27.1 0.53 10.2 2.5 5.9 3 2 3 6 6 6 0 Tetratricopeptide repeat DUF3674 PF12426.3 ESA14526.1 - 0.35 10.3 9.9 85 2.6 0.0 6.3 7 0 0 7 7 7 0 RNA dependent RNA polymerase PixA PF12306.3 ESA14526.1 - 0.94 9.3 7.8 3.4 7.4 0.1 3.3 2 2 1 3 3 3 0 Inclusion body protein CPSase_L_D2 PF02786.12 ESA14528.1 - 8e-112 371.6 0.3 2.5e-81 272.0 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 ESA14528.1 - 9.8e-48 160.9 0.0 2.4e-47 159.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 ESA14528.1 - 6.2e-47 159.5 0.1 4.4e-46 156.7 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 ESA14528.1 - 8.6e-45 151.8 0.0 1.9e-44 150.8 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_chain PF00289.17 ESA14528.1 - 6.9e-44 148.4 0.0 1e-21 77.1 0.0 3.0 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 ESA14528.1 - 9.4e-44 148.1 2.4 1.3e-43 147.7 0.6 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.19 ESA14528.1 - 7.2e-37 126.7 0.3 5.2e-36 123.8 0.0 2.5 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp_4 PF13535.1 ESA14528.1 - 9.6e-34 116.7 0.1 6.1e-23 81.5 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.17 ESA14528.1 - 1.4e-23 82.6 0.0 1.2e-22 79.6 0.0 2.8 2 0 0 2 2 2 1 MGS-like domain ATPgrasp_Ter PF15632.1 ESA14528.1 - 4.1e-20 71.8 0.1 1.3e-11 43.8 0.0 3.8 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 ESA14528.1 - 1.3e-15 57.1 0.1 3.3e-09 36.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESA14528.1 - 1.4e-15 57.2 0.6 5.8e-09 35.6 0.1 3.0 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 ESA14528.1 - 9.6e-08 31.7 0.1 2.1e-06 27.3 0.1 2.5 2 0 0 2 2 2 1 RimK-like ATP-grasp domain Peptidase_C26 PF07722.8 ESA14528.1 - 1.5e-05 24.5 0.2 0.00046 19.6 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 GARS_A PF01071.14 ESA14528.1 - 0.0099 15.4 0.1 0.062 12.8 0.0 2.3 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Vps5 PF09325.5 ESA14528.1 - 0.038 13.2 0.2 0.083 12.1 0.1 1.5 1 0 0 1 1 1 0 Vps5 C terminal like Gmad1 PF10647.4 ESA14528.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain BTB PF00651.26 ESA14529.1 - 1.8e-12 47.1 0.1 3.3e-12 46.3 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA14529.1 - 8.5e-07 29.0 0.4 4.9e-06 26.5 0.3 2.3 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA14529.1 - 8.9e-05 22.2 0.1 0.00034 20.3 0.1 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF4321 PF14209.1 ESA14530.1 - 0.2 11.3 0.9 1.5 8.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4321) Scm3 PF10384.4 ESA14531.1 - 0.017 14.5 0.1 0.037 13.5 0.1 1.6 1 0 0 1 1 1 0 Centromere protein Scm3 COesterase PF00135.23 ESA14531.1 - 0.08 11.6 0.6 0.16 10.6 0.3 1.5 1 1 1 2 2 2 0 Carboxylesterase family TcpQ PF10671.4 ESA14531.1 - 0.086 12.7 0.6 23 4.9 0.0 3.0 1 1 1 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q zf-C2H2 PF00096.21 ESA14534.1 - 3.8e-12 45.7 17.2 4.3e-06 26.7 3.9 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA14534.1 - 3.4e-11 42.8 16.7 1.3e-09 37.9 2.2 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA14534.1 - 3.9e-10 39.3 14.8 3.4e-05 23.8 3.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger TP1 PF02079.11 ESA14534.1 - 0.002 17.8 3.6 0.0021 17.7 1.6 1.6 1 1 1 2 2 2 1 Nuclear transition protein 1 zf-C2H2_6 PF13912.1 ESA14534.1 - 0.002 17.9 12.9 0.012 15.5 0.2 2.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA14534.1 - 0.0058 16.7 9.1 0.47 10.6 2.2 2.5 2 1 1 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.13 ESA14534.1 - 0.027 14.8 4.6 0.034 14.5 3.2 1.1 1 0 0 1 1 1 0 TRAF-type zinc finger zf-met PF12874.2 ESA14534.1 - 0.064 13.4 5.7 0.081 13.1 1.3 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.1 ESA14534.1 - 0.083 12.5 8.0 1.3 8.7 2.0 2.5 2 1 0 2 2 2 0 zinc-finger of a C2HC-type zf-DBF PF07535.7 ESA14534.1 - 0.88 9.2 3.9 2.1 8.0 2.7 1.9 1 1 0 1 1 1 0 DBF zinc finger zf-C2H2_2 PF12756.2 ESA14534.1 - 0.9 9.6 7.1 0.74 9.9 2.2 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF629 PF04780.7 ESA14534.1 - 5 5.5 5.9 11 4.4 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Exo_endo_phos PF03372.18 ESA14535.1 - 7.4e-05 22.7 0.0 0.0001 22.3 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NCD1 PF04904.8 ESA14536.1 - 5.2e-06 26.0 0.0 9.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) NCD2 PF04905.8 ESA14536.1 - 0.0079 16.0 0.1 0.034 13.9 0.0 2.0 2 0 0 2 2 2 1 NAB conserved region 2 (NCD2) SAM_1 PF00536.25 ESA14536.1 - 0.063 13.4 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA14536.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PAM2 PF07145.10 ESA14536.1 - 0.094 12.2 1.4 0.26 10.8 0.9 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region BTB PF00651.26 ESA14537.1 - 1e-14 54.4 0.3 1.3e-14 54.0 0.2 1.2 1 0 0 1 1 1 1 BTB/POZ domain Ost4 PF10215.4 ESA14538.1 - 0.11 11.9 0.2 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Oligosaccaryltransferase Dimer_Tnp_hAT PF05699.9 ESA14539.1 - 1.3e-11 43.9 0.0 1.6e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SPRY PF00622.23 ESA14542.1 - 1.7e-18 66.9 0.2 1.8e-18 66.7 0.1 1.0 1 0 0 1 1 1 1 SPRY domain IBR PF01485.16 ESA14544.1 - 3.2e-19 68.5 18.7 9.2e-12 44.6 0.3 4.3 3 2 1 4 4 4 2 IBR domain zf-C3HC4_2 PF13923.1 ESA14544.1 - 0.00077 19.4 9.6 0.00077 19.4 6.7 4.1 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA14544.1 - 0.0012 18.4 9.1 0.0012 18.4 6.3 3.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA14544.1 - 0.01 15.5 8.9 0.01 15.5 6.2 3.3 3 0 0 3 3 3 0 zinc-RING finger domain zf-RING_4 PF14570.1 ESA14544.1 - 2.7 7.6 31.4 0.03 13.9 8.6 3.4 3 2 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.1 ESA14544.1 - 8.1 6.3 37.1 0.099 12.4 5.2 3.1 3 0 0 3 3 3 0 Ring finger domain CENP-B_dimeris PF09026.5 ESA14545.1 - 0.11 12.7 4.2 0.14 12.4 2.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.4 ESA14545.1 - 3.6 6.1 16.1 4.1 6.0 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Orthopox_B11R PF07033.6 ESA14546.1 - 0.0089 15.4 0.5 2 7.9 0.0 2.2 2 0 0 2 2 2 2 Orthopoxvirus B11R protein Moricin PF06451.6 ESA14547.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Moricin TLD PF07534.11 ESA14549.1 - 9.7e-12 45.0 1.9 1.5e-11 44.4 1.3 1.3 1 0 0 1 1 1 1 TLD DNA_pol_B PF00136.16 ESA14552.1 - 8.1e-15 54.5 0.0 1.3e-14 53.8 0.0 1.3 1 1 0 1 1 1 1 DNA polymerase family B Plus-3 PF03126.13 ESA14552.1 - 0.035 14.1 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 Plus-3 domain Membr_traf_MHD PF10540.4 ESA14553.1 - 0.036 13.8 0.2 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain Imm23 PF15593.1 ESA14554.1 - 0.02 15.1 1.0 0.061 13.5 0.7 1.8 1 0 0 1 1 1 0 Immunity protein 23 DUF3289 PF11692.3 ESA14554.1 - 0.069 12.4 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3289) Pkinase_Tyr PF07714.12 ESA14556.1 - 3.8e-23 81.8 0.2 4.5e-16 58.7 0.0 5.1 5 0 0 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ESA14556.1 - 8.4e-15 54.6 0.4 8.4e-15 54.6 0.3 4.4 5 0 0 5 5 5 1 Protein kinase domain BCS1_N PF08740.6 ESA14556.1 - 2.3e-08 33.9 0.7 0.14 11.7 0.0 5.5 6 0 0 6 6 6 2 BCS1 N terminal NOB1_Zn_bind PF08772.6 ESA14556.1 - 0.00091 19.0 27.4 0.062 13.1 0.2 5.5 5 0 0 5 5 5 3 Nin one binding (NOB1) Zn-ribbon like HSBP1 PF06825.7 ESA14556.1 - 0.017 14.7 2.9 25 4.5 0.0 4.5 4 0 0 4 4 4 0 Heat shock factor binding protein 1 zf-DBF PF07535.7 ESA14556.1 - 0.04 13.5 34.1 0.3 10.8 0.4 5.8 5 3 0 5 5 5 0 DBF zinc finger DUF4413 PF14372.1 ESA14556.1 - 8.4 6.4 12.3 12 5.8 0.0 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) DDE_1 PF03184.14 ESA14557.1 - 3e-20 72.2 0.0 3.5e-20 72.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease BBE PF08031.7 ESA14557.1 - 0.095 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Berberine and berberine like Exo_endo_phos PF03372.18 ESA14558.1 - 0.0057 16.6 0.0 0.0057 16.6 0.0 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family BTB PF00651.26 ESA14559.1 - 8.8e-14 51.4 0.1 1.3e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14559.1 - 2e-06 27.5 0.0 8.6e-06 25.5 0.0 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA14560.1 - 6.7e-17 61.4 0.0 9.6e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14560.1 - 3.2e-06 26.9 0.0 1.1e-05 25.2 0.0 1.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA14561.1 - 8.2e-14 51.7 0.3 9.5e-14 51.5 0.2 1.0 1 0 0 1 1 1 1 TLD ZZ PF00569.12 ESA14563.1 - 8.8e-08 31.5 4.5 8.8e-08 31.5 3.1 2.7 2 1 0 2 2 2 1 Zinc finger, ZZ type zf-B_box PF00643.19 ESA14563.1 - 1.2 9.0 19.8 0.3 10.9 1.8 2.6 2 1 0 2 2 2 0 B-box zinc finger DnaJ PF00226.26 ESA14566.1 - 4.1e-22 77.6 0.9 4.9e-22 77.4 0.6 1.1 1 0 0 1 1 1 1 DnaJ domain SdiA-regulated PF06977.6 ESA14566.1 - 0.099 11.5 0.0 0.1 11.5 0.0 1.0 1 0 0 1 1 1 0 SdiA-regulated DnaJ PF00226.26 ESA14569.1 - 3.8e-26 90.6 4.0 5.7e-26 90.0 2.8 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 ESA14569.1 - 1.2e-23 82.7 0.3 1.1e-21 76.4 0.0 2.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 ESA14569.1 - 1.2e-15 57.3 16.6 1.9e-15 56.6 11.5 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESA14569.1 - 6.7e-05 22.5 2.3 0.019 14.6 0.0 2.3 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family zf-RING_5 PF14634.1 ESA14569.1 - 1.1 9.0 10.2 3.1 7.5 5.1 2.3 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA14569.1 - 4.7 6.9 9.1 27 4.5 6.3 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Arv1 PF04161.8 ESA14570.1 - 1.1e-45 156.1 16.3 8e-32 110.8 0.8 2.2 1 1 1 2 2 2 2 Arv1-like family Ocular_alb PF02101.10 ESA14570.1 - 1.2 7.6 6.7 0.68 8.4 3.1 1.5 1 1 1 2 2 2 0 Ocular albinism type 1 protein Pkinase PF00069.20 ESA14572.1 - 1.5e-61 207.8 0.0 1.9e-61 207.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14572.1 - 1.6e-31 109.3 0.0 2.2e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 ESA14572.1 - 1.6e-09 38.1 0.7 3.6e-09 36.9 0.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 ESA14572.1 - 0.00054 19.0 0.0 0.00088 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA14572.1 - 0.00097 18.2 0.0 0.0018 17.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family KH_1 PF00013.24 ESA14573.1 - 3.2e-08 33.1 0.2 8.5e-08 31.7 0.1 1.8 1 0 0 1 1 1 1 KH domain XH PF03469.9 ESA14573.1 - 0.0071 15.9 1.7 1.2 8.7 0.0 2.6 1 1 1 2 2 2 2 XH domain KH_3 PF13014.1 ESA14573.1 - 0.023 14.3 0.4 0.053 13.1 0.3 1.7 1 0 0 1 1 1 0 KH domain DUF4373 PF14297.1 ESA14573.1 - 0.039 14.2 0.5 0.19 12.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) Aa_trans PF01490.13 ESA14574.1 - 2.7e-14 52.5 24.7 3.6e-14 52.0 17.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESA14574.1 - 0.017 13.9 20.3 0.17 10.6 13.9 2.5 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family DUF2626 PF11117.3 ESA14574.1 - 0.27 11.6 8.5 0.1 13.0 2.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2626) PIN_4 PF13638.1 ESA14575.1 - 7.3e-13 48.7 0.8 1.6e-12 47.6 0.6 1.6 1 0 0 1 1 1 1 PIN domain hSH3 PF14603.1 ESA14575.1 - 0.079 12.9 0.1 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Helically-extended SH3 domain EF-hand_1 PF00036.27 ESA14576.1 - 1.4e-24 83.4 14.4 3.8e-07 28.9 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESA14576.1 - 5.7e-22 77.6 4.4 1.1e-11 44.6 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 ESA14576.1 - 1.6e-18 65.1 12.3 4.3e-05 22.6 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESA14576.1 - 1.8e-18 64.7 9.4 5e-05 22.8 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 ESA14576.1 - 2.6e-13 49.3 16.2 6e-05 22.5 1.0 4.7 3 2 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESA14576.1 - 5.7e-07 29.5 0.1 0.00092 19.2 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 ESA14576.1 - 0.00042 20.0 8.0 0.014 15.1 0.9 3.6 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 ESA14576.1 - 0.036 13.9 0.1 0.7 9.8 0.0 2.7 2 1 1 3 3 3 0 EF-hand domain TAFII28 PF04719.9 ESA14577.1 - 2.3e-33 113.8 0.0 2.8e-33 113.5 0.0 1.1 1 0 0 1 1 1 1 hTAFII28-like protein conserved region AAA_35 PF14516.1 ESA14577.1 - 0.036 12.7 0.0 0.038 12.6 0.0 1.0 1 0 0 1 1 1 0 AAA-like domain DUF4565 PF15127.1 ESA14577.1 - 0.14 12.5 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4565) zf-Tim10_DDP PF02953.10 ESA14579.1 - 1.4e-21 75.5 3.0 2.1e-21 74.9 2.1 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Vicilin_N PF04702.7 ESA14579.1 - 0.035 13.7 3.4 0.043 13.4 2.4 1.2 1 0 0 1 1 1 0 Vicilin N terminal region DUF842 PF05811.8 ESA14579.1 - 0.074 12.5 5.8 0.13 11.7 4.0 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) UQ_con PF00179.21 ESA14580.1 - 4.3e-43 146.1 0.0 4.8e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA14580.1 - 0.096 12.5 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF3684 PF12449.3 ESA14581.1 - 2.5e-224 747.2 1.8 1.9e-221 737.7 0.7 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA14581.1 - 7.3e-07 28.9 0.0 2e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA14581.1 - 0.016 14.9 0.0 0.045 13.4 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SAM_1 PF00536.25 ESA14582.1 - 3e-05 24.0 0.2 0.00018 21.5 0.0 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA14582.1 - 0.03 14.1 0.0 0.087 12.6 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF1372 PF07116.6 ESA14582.1 - 0.05 13.5 0.5 0.17 11.8 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1372) Ku_PK_bind PF08785.6 ESA14582.1 - 0.065 13.1 3.2 0.21 11.4 2.2 1.9 1 0 0 1 1 1 0 Ku C terminal domain like zf-CCHC PF00098.18 ESA14583.1 - 0.0084 16.0 4.4 0.018 14.9 3.1 1.6 1 0 0 1 1 1 1 Zinc knuckle Utp13 PF08625.6 ESA14583.1 - 0.036 13.7 0.4 0.061 12.9 0.0 1.6 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain Imm39 PF15600.1 ESA14586.1 - 0.0016 18.2 3.9 0.0094 15.8 1.8 2.3 1 1 1 2 2 2 1 Immunity protein 39 Pkinase_Tyr PF07714.12 ESA14586.1 - 0.0059 15.7 0.3 0.38 9.7 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA14587.1 - 1e-42 145.9 0.0 1.2e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14587.1 - 1.3e-38 132.6 0.5 1.6e-38 132.3 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA14587.1 - 0.0089 15.0 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA14587.1 - 0.0099 14.9 0.2 0.015 14.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA14587.1 - 0.019 14.6 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-met PF12874.2 ESA14589.1 - 0.0032 17.6 1.6 0.0066 16.6 1.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESA14589.1 - 0.018 15.1 0.1 0.031 14.4 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 ESA14589.1 - 0.035 14.2 1.2 0.081 13.0 0.9 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding SAICAR_synt PF01259.13 ESA14590.1 - 6.8e-64 215.3 0.7 2.1e-34 118.7 0.0 2.5 1 1 1 2 2 2 2 SAICAR synthetase SNF2_N PF00176.18 ESA14592.1 - 2.4e-46 157.9 0.0 5.6e-46 156.6 0.0 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 ESA14592.1 - 1.2e-13 50.4 0.4 9.9e-09 34.7 0.0 3.1 2 1 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.24 ESA14592.1 - 1.5e-08 34.2 0.0 3.6e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.24 ESA14592.1 - 3e-06 26.8 23.2 0.0002 20.9 5.8 3.1 3 0 0 3 3 3 2 PHD-finger zf-PHD-like PF15446.1 ESA14592.1 - 0.00046 19.5 27.0 0.026 13.8 7.7 2.9 2 1 1 3 3 3 2 PHD/FYVE-zinc-finger like domain DUF479 PF04336.7 ESA14593.1 - 0.095 12.8 0.1 0.22 11.6 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF479 PLDc_2 PF13091.1 ESA14594.1 - 6.5e-10 38.8 1.8 2.1e-08 33.9 1.2 2.5 2 1 0 2 2 2 1 PLD-like domain PLDc PF00614.17 ESA14594.1 - 2.1e-05 24.1 0.3 5.2e-05 22.8 0.2 1.7 1 0 0 1 1 1 1 Phospholipase D Active site motif Ins145_P3_rec PF08709.6 ESA14595.1 - 2.4e-06 26.7 0.4 5.7e-06 25.5 0.0 1.8 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA14595.1 - 0.0001 21.9 0.4 0.0004 19.9 0.3 2.0 1 1 0 1 1 1 1 MIR domain DUF569 PF04601.8 ESA14595.1 - 0.09 12.2 0.2 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF569) MIR PF02815.14 ESA14596.1 - 0.072 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 MIR domain Pkinase PF00069.20 ESA14597.1 - 1.1e-29 103.3 0.0 1.3e-29 103.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14597.1 - 2.2e-29 102.3 0.0 2.5e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA14597.1 - 8.8e-05 21.6 0.3 0.00018 20.6 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA14597.1 - 0.0013 18.1 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA14597.1 - 0.0025 17.0 0.0 0.0039 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA14597.1 - 0.0063 15.5 0.0 0.008 15.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA14597.1 - 0.015 15.0 0.2 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pab87_oct PF13969.1 ESA14599.1 - 0.028 14.5 0.0 0.074 13.1 0.0 1.7 1 0 0 1 1 1 0 Pab87 octamerisation domain DIOX_N PF14226.1 ESA14600.1 - 1.1e-05 25.9 0.0 4.6e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESA14600.1 - 0.00065 19.9 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Trypan_PARP PF05887.6 ESA14603.1 - 0.065 13.0 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Phage_Gp111 PF07410.6 ESA14604.1 - 0.0004 20.4 0.2 7.5 6.7 0.0 3.4 3 0 0 3 3 3 2 Streptococcus thermophilus bacteriophage Gp111 protein CDC45 PF02724.9 ESA14604.1 - 0.002 16.2 10.0 0.0028 15.7 6.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.7 ESA14604.1 - 0.011 13.6 13.0 0.018 12.9 9.0 1.2 1 0 0 1 1 1 0 Nop14-like family DUF953 PF06110.6 ESA14604.1 - 0.031 13.7 3.2 0.24 10.8 0.2 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Jiv90 PF14901.1 ESA14604.1 - 0.097 12.6 0.2 0.097 12.6 0.2 4.5 3 1 1 4 4 4 0 Cleavage inducing molecular chaperone DUF2457 PF10446.4 ESA14604.1 - 0.11 11.2 21.5 0.19 10.4 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) YL1 PF05764.8 ESA14604.1 - 0.91 9.0 11.5 1.9 8.0 7.9 1.4 1 0 0 1 1 1 0 YL1 nuclear protein BTB_2 PF02214.17 ESA14605.1 - 6e-20 71.2 0.2 7.4e-20 70.9 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain COMPASS-Shg1 PF05205.7 ESA14605.1 - 0.11 12.8 0.3 0.16 12.2 0.2 1.4 1 1 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Flavodoxin_NdrI PF07972.6 ESA14606.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 NrdI Flavodoxin like Pkinase PF00069.20 ESA14607.1 - 2.2e-20 72.8 0.1 2.6e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14607.1 - 8e-20 70.9 0.0 9.4e-20 70.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mgr1 PF08602.5 ESA14607.1 - 0.059 12.3 0.2 0.068 12.1 0.1 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit TLD PF07534.11 ESA14608.1 - 4.2e-13 49.4 2.0 6.5e-13 48.8 1.4 1.3 1 0 0 1 1 1 1 TLD DUF3322 PF11795.3 ESA14608.1 - 0.11 12.0 0.1 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) CLASP_N PF12348.3 ESA14610.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 CLASP N terminal HSP70 PF00012.15 ESA14613.1 - 2.5e-104 349.3 7.1 1.7e-103 346.5 4.9 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA14613.1 - 9.2e-09 34.3 0.0 2.6e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 MreB/Mbl protein PseudoU_synth_2 PF00849.17 ESA14614.1 - 1.5e-27 96.4 0.0 2.1e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF261 PF03196.8 ESA14614.1 - 0.033 14.1 0.1 0.091 12.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF261 TRAPP PF04051.11 ESA14615.1 - 4e-43 146.5 0.0 5.1e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component MRP-S33 PF08293.6 ESA14616.1 - 1.1e-28 99.0 0.2 1.3e-28 98.8 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Rad51 PF08423.6 ESA14617.1 - 0.00084 18.3 0.1 0.0079 15.1 0.0 2.3 2 1 0 2 2 2 1 Rad51 OHCU_decarbox PF09349.5 ESA14618.1 - 3.6e-37 128.0 0.1 5e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 OHCU decarboxylase Pkinase PF00069.20 ESA14619.1 - 3.5e-48 164.0 0.0 5.7e-48 163.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14619.1 - 1.5e-43 148.7 0.0 2.1e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA14619.1 - 8.5e-40 134.3 9.9 6.1e-08 33.0 0.0 7.1 7 0 0 7 7 7 6 Sel1 repeat TPR_7 PF13176.1 ESA14619.1 - 0.00017 21.1 1.9 0.1 12.4 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat RIO1 PF01163.17 ESA14619.1 - 0.00018 20.9 0.1 0.00045 19.6 0.1 1.6 1 0 0 1 1 1 1 RIO1 family TPR_11 PF13414.1 ESA14619.1 - 0.0029 17.2 12.8 2 8.1 0.2 3.9 2 1 0 3 3 3 3 TPR repeat TPR_6 PF13174.1 ESA14619.1 - 0.0071 16.7 7.6 4.7 7.8 0.3 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat Kinase-like PF14531.1 ESA14619.1 - 0.032 13.1 0.0 4.2 6.2 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.9 ESA14619.1 - 0.053 12.5 0.0 0.15 11.1 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIT PF04212.13 ESA14619.1 - 0.15 11.9 11.9 14 5.6 0.1 4.6 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.12 ESA14620.1 - 1.5e-38 132.3 0.0 4.2e-38 130.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14620.1 - 2.6e-34 118.5 0.2 5.1e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA14620.1 - 9.1e-07 29.3 5.7 1.7e-06 28.4 0.5 2.8 2 0 0 2 2 2 1 Sel1 repeat DUF2524 PF10732.4 ESA14620.1 - 0.14 12.2 4.0 0.49 10.5 1.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2524) Ribosomal_L17 PF01196.14 ESA14620.1 - 0.19 12.3 3.7 0.99 10.0 0.3 2.6 2 0 0 2 2 2 0 Ribosomal protein L17 TPR_16 PF13432.1 ESA14620.1 - 0.92 10.2 3.7 1.5 9.5 0.5 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Lon_2 PF13337.1 ESA14621.1 - 0.039 12.2 0.2 0.076 11.3 0.0 1.5 2 0 0 2 2 2 0 Putative ATP-dependent Lon protease RapA_C PF12137.3 ESA14621.1 - 0.088 11.6 0.2 0.2 10.4 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal HOOK PF05622.7 ESA14621.1 - 0.13 10.0 6.0 0.056 11.2 2.2 1.6 1 1 0 1 1 1 0 HOOK protein DUF904 PF06005.7 ESA14621.1 - 0.92 9.8 8.0 0.24 11.7 2.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF972 PF06156.8 ESA14621.1 - 1.4 9.2 5.4 0.86 9.9 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) F-box-like PF12937.2 ESA14622.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 F-box-like HTH_11 PF08279.7 ESA14624.1 - 0.0014 18.2 1.5 0.41 10.3 0.2 2.6 1 1 2 3 3 3 3 HTH domain HTH_38 PF13936.1 ESA14624.1 - 0.0092 15.5 5.8 0.8 9.3 0.0 4.1 1 1 3 4 4 4 2 Helix-turn-helix domain IF2_N PF04760.10 ESA14624.1 - 0.3 10.7 2.9 4.7 6.9 0.2 3.0 1 1 2 3 3 3 0 Translation initiation factor IF-2, N-terminal region GST_C PF00043.20 ESA14626.1 - 2.2e-15 56.3 0.0 3.1e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA14626.1 - 3.7e-12 46.2 0.0 7.2e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA14626.1 - 2.3e-10 40.4 0.0 4.1e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA14626.1 - 1.2e-07 31.4 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESA14626.1 - 4.8e-07 29.6 0.0 8.4e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Nsp1_C PF05064.8 ESA14626.1 - 0.064 12.8 0.1 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region MetRS-N PF09635.5 ESA14626.1 - 0.073 13.4 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 MetRS-N binding domain BTB PF00651.26 ESA14627.1 - 2.1e-08 34.1 0.2 8.6e-08 32.1 0.0 1.8 1 1 1 2 2 2 1 BTB/POZ domain WSC PF01822.14 ESA14627.1 - 0.092 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 WSC domain DUF3700 PF12481.3 ESA14628.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Aluminium induced protein ABC_trans_N PF14510.1 ESA14630.1 - 0.07 13.2 0.1 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 ABC-transporter extracellular N-terminal His_binding PF02098.11 ESA14630.1 - 0.089 12.6 3.3 0.093 12.5 2.3 1.1 1 0 0 1 1 1 0 Tick histamine binding protein Colicin_D PF11429.3 ESA14630.1 - 0.16 12.1 3.3 0.7 10.0 0.2 2.1 1 1 1 2 2 2 0 Colicin D Myb_DNA-bind_4 PF13837.1 ESA14635.1 - 5.3e-06 26.4 1.1 1.4e-05 25.1 0.8 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain TIG PF01833.19 ESA14635.1 - 0.022 14.7 4.2 3.5 7.6 0.3 3.3 1 1 2 3 3 3 0 IPT/TIG domain YqzE PF14038.1 ESA14636.1 - 0.0024 17.5 0.2 0.0044 16.7 0.1 1.4 1 0 0 1 1 1 1 YqzE-like protein DUF1348 PF07080.6 ESA14637.1 - 7.2e-56 187.9 7.5 8.4e-56 187.7 5.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.2 ESA14637.1 - 1.9e-05 24.9 0.2 2.5e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 ESA14637.1 - 0.0065 16.6 0.0 0.0087 16.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Phenol_Hydrox PF02332.13 ESA14637.1 - 2.2 7.5 7.8 0.58 9.4 3.3 1.6 2 0 0 2 2 2 0 Methane/Phenol/Toluene Hydroxylase SSXT PF05030.7 ESA14638.1 - 2.4e-08 33.4 2.6 2.8e-08 33.1 0.3 2.3 2 0 0 2 2 2 1 SSXT protein (N-terminal region) NOB1_Zn_bind PF08772.6 ESA14639.1 - 0.059 13.1 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF1406 PF07190.6 ESA14639.1 - 0.28 10.8 3.5 0.61 9.7 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1406) Sel1 PF08238.7 ESA14641.1 - 6e-47 157.0 10.6 5.9e-12 45.8 0.0 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA14641.1 - 0.00058 20.1 2.6 1.3 9.6 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA14641.1 - 0.015 15.3 0.0 49 4.0 0.0 3.5 1 1 3 4 4 4 0 Influenza Matrix protein (M1) C-terminal domain TPR_17 PF13431.1 ESA14641.1 - 0.25 11.6 8.1 2.7 8.3 0.3 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA14641.1 - 0.45 10.2 11.7 1.1 8.9 0.4 3.9 2 1 2 4 4 4 0 TPR repeat Uma2 PF05685.7 ESA14642.1 - 4.6e-10 39.1 0.0 5e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Putative restriction endonuclease Ifi-6-16 PF06140.8 ESA14643.1 - 0.00015 21.4 18.4 0.00024 20.8 12.7 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family Herpes_LMP2 PF07415.6 ESA14644.1 - 0.093 11.3 2.0 0.11 11.1 1.4 1.0 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein BTB PF00651.26 ESA14645.1 - 1.2e-14 54.2 0.1 2.8e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14645.1 - 7.3e-14 51.4 7.5 9.2e-09 35.0 0.8 4.3 3 1 1 4 4 4 2 BTB And C-terminal Kelch Urm1 PF09138.6 ESA14645.1 - 0.066 13.3 0.6 0.16 12.0 0.2 1.9 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Cupin_4 PF08007.7 ESA14645.1 - 0.07 12.3 0.2 0.11 11.6 0.1 1.4 1 0 0 1 1 1 0 Cupin superfamily protein DUF3342 PF11822.3 ESA14645.1 - 0.13 11.3 0.6 0.18 10.9 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) SapB_1 PF05184.10 ESA14645.1 - 1.7 8.5 3.9 0.72 9.7 0.1 2.4 3 0 0 3 3 3 0 Saposin-like type B, region 1 BTB PF00651.26 ESA14646.1 - 2.7e-14 53.0 0.2 7.2e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14646.1 - 6e-10 38.8 7.0 7.2e-08 32.2 1.0 3.5 3 1 1 4 4 4 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA14646.1 - 0.013 15.6 0.1 0.21 11.6 0.0 2.9 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain FAM178 PF14816.1 ESA14647.1 - 4e-06 25.7 0.6 6.3e-06 25.1 0.4 1.2 1 0 0 1 1 1 1 Family of unknown function, FAM178 WD40 PF00400.27 ESA14648.1 - 7e-22 76.4 11.8 5.9e-10 38.6 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat Rep_fac-A_C PF08646.5 ESA14648.1 - 0.0072 16.0 4.9 0.026 14.2 3.4 1.9 1 0 0 1 1 1 1 Replication factor-A C terminal domain DUF4182 PF13790.1 ESA14648.1 - 5.5 6.8 8.3 14 5.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) WD40 PF00400.27 ESA14649.1 - 5.4e-32 108.5 15.2 1.9e-06 27.4 0.1 6.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.9 ESA14649.1 - 2.1e-31 107.8 12.3 2.1e-31 107.8 8.5 1.6 2 0 0 2 2 2 1 Sof1-like domain DUF3260 PF11658.3 ESA14650.1 - 0.056 11.5 0.1 0.086 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3260) Peptidase_M4 PF01447.13 ESA14652.1 - 0.71 9.9 4.2 0.2 11.7 0.4 1.9 2 0 0 2 2 2 0 Thermolysin metallopeptidase, catalytic domain Pkinase_Tyr PF07714.12 ESA14654.1 - 9.1e-30 103.5 0.0 3.4e-14 52.5 0.0 4.2 3 2 1 5 5 5 3 Protein tyrosine kinase Pkinase PF00069.20 ESA14654.1 - 8.9e-25 87.3 6.0 1.6e-16 60.2 0.0 4.0 3 1 1 4 4 4 2 Protein kinase domain BCS1_N PF08740.6 ESA14654.1 - 1.2e-05 25.0 0.2 1.9 8.0 0.0 3.9 4 0 0 4 4 4 3 BCS1 N terminal Complex1_30kDa PF00329.14 ESA14654.1 - 0.0015 18.7 0.0 0.091 13.0 0.0 2.5 2 0 0 2 2 2 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit AAA_5 PF07728.9 ESA14655.1 - 6.7e-07 29.1 0.0 1.9e-05 24.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA14655.1 - 0.00017 21.7 0.1 0.0019 18.3 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA14655.1 - 0.00071 19.7 0.0 0.024 14.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 ESA14655.1 - 0.002 18.5 0.0 0.0053 17.2 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein Sigma54_activ_2 PF14532.1 ESA14655.1 - 0.0029 17.6 0.0 0.29 11.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.1 ESA14655.1 - 0.024 14.5 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA14655.1 - 0.035 14.4 0.3 0.73 10.1 0.0 2.5 2 1 0 2 2 2 0 ABC transporter T2SE PF00437.15 ESA14655.1 - 0.039 12.8 0.0 0.08 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_10 PF12846.2 ESA14655.1 - 0.048 13.0 0.0 2 7.7 0.0 2.4 2 1 0 2 2 2 0 AAA-like domain RNA_helicase PF00910.17 ESA14655.1 - 0.056 13.6 0.0 0.6 10.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.1 ESA14655.1 - 0.11 12.7 0.3 0.47 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESA14655.1 - 0.12 12.3 0.0 3.6 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain Viral_helicase1 PF01443.13 ESA14655.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF258 PF03193.11 ESA14655.1 - 0.14 11.3 0.1 0.43 9.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF755 PF05501.6 ESA14656.1 - 0.017 15.1 1.7 0.033 14.2 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pkinase_Tyr PF07714.12 ESA14656.1 - 0.033 13.2 0.1 0.27 10.2 0.0 2.1 1 1 1 2 2 2 0 Protein tyrosine kinase DUF1322 PF07032.6 ESA14658.1 - 0.074 13.2 0.2 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1322) Transthyretin PF00576.16 ESA14659.1 - 6.1e-33 113.0 0.2 9.5e-33 112.4 0.1 1.3 1 1 0 1 1 1 1 HIUase/Transthyretin family DUF3601 PF12208.3 ESA14659.1 - 0.01 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3601) Utp11 PF03998.8 ESA14660.1 - 1.4e-73 247.7 21.0 1.6e-73 247.5 14.6 1.0 1 0 0 1 1 1 1 Utp11 protein Flu_NS2 PF00601.14 ESA14660.1 - 0.14 12.3 0.2 0.14 12.3 0.1 3.1 1 1 2 3 3 3 0 Influenza non-structural protein (NS2) WD40 PF00400.27 ESA14661.1 - 8.7e-53 174.4 30.4 5.1e-10 38.8 1.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat NLE PF08154.7 ESA14661.1 - 1.6e-23 82.4 0.3 1.1e-22 79.8 0.1 2.1 2 0 0 2 2 2 1 NLE (NUC135) domain eIF2A PF08662.6 ESA14661.1 - 0.0023 17.6 0.7 0.072 12.7 0.0 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Zw10 PF06248.8 ESA14662.1 - 0.0083 14.3 0.5 0.0098 14.0 0.4 1.1 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 F5_F8_type_C PF00754.20 ESA14666.1 - 0.029 14.2 0.4 0.069 12.9 0.3 1.6 1 0 0 1 1 1 0 F5/8 type C domain DUF1059 PF06348.6 ESA14666.1 - 0.06 13.1 0.6 0.19 11.5 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1059) Med4 PF10018.4 ESA14666.1 - 0.5 9.7 7.7 1.2 8.5 0.1 4.2 3 1 2 5 5 5 0 Vitamin-D-receptor interacting Mediator subunit 4 AAA PF00004.24 ESA14667.1 - 6.2e-19 68.5 0.0 1.5e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA14667.1 - 2.5e-05 24.4 0.5 0.00073 19.6 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 ESA14667.1 - 4e-05 24.4 0.2 0.00015 22.6 0.1 2.1 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESA14667.1 - 7.2e-05 22.8 2.1 0.00019 21.5 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain Zot PF05707.7 ESA14667.1 - 0.00065 19.2 0.2 0.05 13.0 0.0 2.5 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) AAA_18 PF13238.1 ESA14667.1 - 0.0008 19.7 0.3 0.0039 17.5 0.0 2.3 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.9 ESA14667.1 - 0.0022 17.7 0.0 0.0047 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESA14667.1 - 0.0035 17.0 0.2 0.0091 15.7 0.0 1.7 2 0 0 2 2 2 1 Part of AAA domain AAA_2 PF07724.9 ESA14667.1 - 0.014 15.2 0.0 0.056 13.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 ESA14667.1 - 0.017 14.2 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 ESA14667.1 - 0.028 13.8 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 ESA14667.1 - 0.044 12.9 0.1 0.1 11.7 0.1 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 ESA14667.1 - 0.077 12.5 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 ESA14667.1 - 0.091 11.4 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus KaiC PF06745.8 ESA14667.1 - 0.63 9.1 2.8 7.2 5.6 0.3 2.5 1 1 1 2 2 2 0 KaiC NUMOD1 PF07453.8 ESA14668.1 - 0.057 13.2 0.1 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 NUMOD1 domain MSP7_C PF12948.2 ESA14672.1 - 0.025 14.8 0.3 0.025 14.8 0.2 1.1 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain VKOR PF07884.9 ESA14673.1 - 0.047 13.5 0.3 0.092 12.5 0.2 1.4 1 0 0 1 1 1 0 Vitamin K epoxide reductase family AATase PF07247.7 ESA14674.1 - 0.032 12.7 0.2 0.032 12.7 0.1 1.0 1 0 0 1 1 1 0 Alcohol acetyltransferase Pkinase_Tyr PF07714.12 ESA14677.1 - 2.9e-41 141.2 0.0 3.6e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14677.1 - 1.4e-39 135.8 0.7 2.9e-39 134.7 0.5 1.4 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA14677.1 - 0.0047 16.5 0.0 0.0094 15.5 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal TMEM18 PF14770.1 ESA14680.1 - 6.4e-35 119.3 2.3 8.3e-35 118.9 1.6 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 BPD_transp_2 PF02653.11 ESA14680.1 - 0.059 12.3 1.0 0.073 12.0 0.7 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component Herp-Cyclin PF09241.5 ESA14681.1 - 0.054 13.7 0.0 0.066 13.5 0.0 1.1 1 0 0 1 1 1 0 Herpesviridae viral cyclin Ribosomal_S19 PF00203.16 ESA14682.1 - 2.4e-15 55.8 0.0 3.1e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 DTW PF03942.10 ESA14683.1 - 8.3e-26 90.4 0.1 1.5e-25 89.6 0.0 1.4 1 1 0 1 1 1 1 DTW domain PEARLI-4 PF05278.7 ESA14684.1 - 0.0061 15.9 4.2 0.0099 15.2 2.3 1.8 1 1 0 1 1 1 1 Arabidopsis phospholipase-like protein (PEARLI 4) Macoilin PF09726.4 ESA14684.1 - 0.044 12.0 15.5 0.071 11.3 10.7 1.2 1 1 0 1 1 1 0 Transmembrane protein Zein-binding PF04576.10 ESA14684.1 - 0.074 13.1 4.3 0.1 12.6 1.8 2.2 1 1 1 2 2 2 0 Zein-binding DUF605 PF04652.11 ESA14684.1 - 0.25 10.7 10.1 0.34 10.2 7.0 1.2 1 0 0 1 1 1 0 Vta1 like CCDC32 PF14989.1 ESA14684.1 - 0.41 10.4 6.6 0.16 11.7 0.2 2.9 1 1 2 3 3 3 0 Coiled-coil domain containing 32 Peptidase_S64 PF08192.6 ESA14684.1 - 0.46 8.7 11.3 0.73 8.0 7.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 DUF1664 PF07889.7 ESA14684.1 - 0.68 9.7 6.2 0.56 10.0 2.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.13 ESA14684.1 - 0.87 8.5 5.5 1.8 7.5 3.8 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ndc1_Nup PF09531.5 ESA14684.1 - 1.5 7.1 8.8 2 6.7 6.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sec2p PF06428.6 ESA14684.1 - 1.9 8.3 12.5 6.9 6.5 1.8 3.1 2 2 0 2 2 2 0 GDP/GTP exchange factor Sec2p DS PF01916.12 ESA14685.1 - 1.5e-141 470.8 0.0 1.8e-141 470.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase OTT_1508_deam PF14441.1 ESA14686.1 - 1.3e-13 50.9 0.2 2.9e-13 49.8 0.2 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase Gemin6 PF06372.7 ESA14687.1 - 8.1e-14 51.2 0.8 9.9e-14 50.9 0.6 1.1 1 0 0 1 1 1 1 Gemin6 protein Sipho_Gp157 PF05565.6 ESA14687.1 - 1.3 8.6 5.6 4.5 6.8 1.4 2.7 2 1 1 3 3 3 0 Siphovirus Gp157 Peptidase_M41 PF01434.13 ESA14689.1 - 2.5e-73 246.0 5.8 4e-73 245.4 4.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 ESA14689.1 - 7.9e-43 145.8 0.0 1.8e-42 144.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA14689.1 - 6.8e-06 26.9 0.0 2.2e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESA14689.1 - 1.6e-05 23.8 0.0 3.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 ESA14689.1 - 2.5e-05 23.9 0.0 7.5e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA14689.1 - 2.7e-05 24.2 0.4 0.0012 18.8 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 ESA14689.1 - 8.2e-05 22.2 0.1 0.00022 20.8 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 ESA14689.1 - 0.00012 22.2 0.9 0.013 15.6 0.1 3.2 3 1 0 3 3 2 1 AAA domain RuvB_N PF05496.7 ESA14689.1 - 0.00025 20.1 0.0 0.0015 17.6 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESA14689.1 - 0.00063 19.1 3.8 0.017 14.5 0.3 3.1 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.12 ESA14689.1 - 0.0017 17.7 0.1 0.0038 16.6 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 ESA14689.1 - 0.0035 17.3 0.6 0.0098 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESA14689.1 - 0.0074 16.1 0.0 0.021 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA14689.1 - 0.01 16.1 0.0 0.03 14.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.16 ESA14689.1 - 0.012 14.8 0.2 0.037 13.1 0.1 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 ESA14689.1 - 0.013 15.4 0.0 0.093 12.6 0.0 2.5 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 ESA14689.1 - 0.025 13.6 0.1 0.051 12.6 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 ESA14689.1 - 0.03 14.2 0.0 0.089 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESA14689.1 - 0.039 13.9 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.7 ESA14689.1 - 0.073 12.7 0.3 0.82 9.3 0.1 2.2 2 0 0 2 2 2 0 NACHT domain KaiC PF06745.8 ESA14689.1 - 0.11 11.5 3.6 0.17 11.0 0.0 2.9 4 0 0 4 4 4 0 KaiC FYVE_2 PF02318.11 ESA14690.1 - 1.6 8.6 15.7 7.5 6.4 6.2 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger Vps39_2 PF10367.4 ESA14690.1 - 3.8 7.7 10.8 1.4 9.1 0.0 3.4 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 RVT_1 PF00078.22 ESA14693.1 - 2.7e-16 59.5 0.1 3.1e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESA14694.1 - 0.00024 20.7 1.1 0.00035 20.1 0.8 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA14694.1 - 0.0012 18.8 0.0 0.0012 18.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SusD-like_3 PF14322.1 ESA14694.1 - 0.056 13.4 1.8 0.093 12.7 1.3 1.4 1 0 0 1 1 1 0 Starch-binding associating with outer membrane HTH_Tnp_1_2 PF13022.1 ESA14694.1 - 0.063 13.0 0.6 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase B1 PF02246.10 ESA14696.1 - 0.091 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein L b1 domain Ribosomal_S13_N PF08069.7 ESA14697.1 - 0.15 11.9 0.7 0.4 10.5 0.2 1.9 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain RIG-I_C-RD PF11648.3 ESA14697.1 - 0.31 10.9 2.6 0.29 11.0 0.4 2.1 1 1 0 1 1 1 0 C-terminal domain of RIG-I DUF4182 PF13790.1 ESA14698.1 - 0.91 9.3 9.5 1.5 8.7 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) HTH_Tnp_Tc5 PF03221.11 ESA14700.1 - 5.8e-10 38.8 0.3 1.1e-09 37.9 0.2 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA14700.1 - 6.6e-06 25.4 0.5 1.8e-05 24.0 0.2 1.8 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain Sel1 PF08238.7 ESA14701.1 - 1.1e-07 32.1 0.5 2.5e-06 27.9 0.1 2.1 2 0 0 2 2 2 1 Sel1 repeat TPR_11 PF13414.1 ESA14701.1 - 0.0016 18.0 0.3 0.0022 17.6 0.2 1.4 1 1 0 1 1 1 1 TPR repeat TPR_17 PF13431.1 ESA14701.1 - 0.0018 18.3 0.3 0.003 17.6 0.2 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA14701.1 - 0.069 13.8 0.2 0.31 11.7 0.2 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA14701.1 - 0.15 11.9 2.9 2.3 8.1 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA14701.1 - 0.15 12.5 2.6 0.34 11.4 0.9 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat HMG_box PF00505.14 ESA14703.1 - 2.5e-09 37.2 6.6 2.5e-09 37.2 4.6 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box TLD PF07534.11 ESA14704.1 - 4.6e-12 46.1 4.3 7.9e-12 45.3 3.0 1.4 1 0 0 1 1 1 1 TLD TLD PF07534.11 ESA14705.1 - 6.2e-15 55.4 3.0 2e-14 53.7 0.9 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA14705.1 - 1.7e-06 27.7 0.0 5.7e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 BTB And C-terminal Kelch TLD PF07534.11 ESA14706.1 - 1.5e-06 28.2 0.9 1.8e-06 28.0 0.6 1.1 1 0 0 1 1 1 1 TLD Cas_Cas4 PF01930.12 ESA14708.1 - 4.3e-08 33.2 0.8 2e-07 31.0 0.0 2.4 2 1 1 3 3 3 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.2 ESA14708.1 - 1.4e-07 31.2 0.1 2.8e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily ATP-grasp_4 PF13535.1 ESA14709.1 - 6.9e-15 55.2 0.0 6.6e-14 52.0 0.0 2.3 2 1 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 ESA14709.1 - 1.3e-07 31.2 0.0 6.3e-07 28.9 0.0 2.3 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 ESA14709.1 - 5.3e-06 26.3 0.0 9.3e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESA14709.1 - 8.1e-06 24.8 0.0 1.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATPgrasp_ST PF14397.1 ESA14709.1 - 8.2e-05 21.8 0.0 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp GARS_A PF01071.14 ESA14709.1 - 0.0003 20.4 0.0 0.00076 19.0 0.0 1.6 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.12 ESA14709.1 - 0.012 14.8 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.6 ESA14709.1 - 0.071 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain TauD PF02668.11 ESA14710.1 - 4e-09 36.5 0.0 5.9e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Pkinase_Tyr PF07714.12 ESA14711.1 - 6.9e-44 149.8 0.1 1.1e-43 149.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14711.1 - 2e-36 125.4 0.3 3.9e-36 124.5 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA14711.1 - 1.3e-15 57.4 0.4 1.2e-06 28.9 0.0 2.9 2 0 0 2 2 2 2 Sel1 repeat Kdo PF06293.9 ESA14711.1 - 0.015 14.3 0.0 0.029 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40_alt PF14077.1 ESA14711.1 - 0.045 13.3 0.8 0.14 11.8 0.6 1.9 1 0 0 1 1 1 0 Alternative WD40 repeat motif Reo_sigmaC PF04582.7 ESA14711.1 - 0.047 12.8 0.2 0.074 12.2 0.1 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESA14711.1 - 0.061 13.5 2.8 0.2 11.9 1.9 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.7 ESA14711.1 - 0.22 11.2 4.9 0.21 11.3 1.8 2.2 2 1 0 2 2 2 0 Laminin Domain II STAT_alpha PF01017.15 ESA14711.1 - 1.4 8.6 8.0 3.1 7.4 5.6 1.6 1 1 0 1 1 1 0 STAT protein, all-alpha domain Img2 PF05046.9 ESA14712.1 - 0.02 15.1 1.7 1.9 8.7 0.1 2.7 1 1 2 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) Sec34 PF04136.10 ESA14712.1 - 0.022 14.4 5.1 2.1 8.0 0.1 2.4 2 1 0 2 2 2 0 Sec34-like family Mod_r PF07200.8 ESA14712.1 - 0.026 14.4 2.3 0.048 13.5 0.1 2.3 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Pox_Ag35 PF03286.9 ESA14712.1 - 0.031 13.7 0.1 0.031 13.7 0.1 1.9 2 1 1 3 3 3 0 Pox virus Ag35 surface protein Reo_sigmaC PF04582.7 ESA14712.1 - 0.044 12.9 1.8 0.16 11.1 0.2 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NTPase_I-T PF01931.13 ESA14712.1 - 0.046 13.4 0.3 0.15 11.7 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF84 DUF972 PF06156.8 ESA14712.1 - 0.15 12.3 7.0 0.39 11.0 0.5 3.4 2 1 1 4 4 4 0 Protein of unknown function (DUF972) DUF1664 PF07889.7 ESA14712.1 - 0.23 11.2 2.6 1.1 9.0 0.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 ESA14712.1 - 0.53 10.5 3.8 7 6.9 0.3 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein F-box-like PF12937.2 ESA14714.1 - 0.00027 20.5 2.4 0.00038 20.1 0.6 2.1 2 0 0 2 2 2 1 F-box-like GAT PF03127.9 ESA14714.1 - 0.034 14.1 0.2 1.1 9.3 0.0 2.8 2 0 0 2 2 2 0 GAT domain Dimer_Tnp_hAT PF05699.9 ESA14716.1 - 6.6e-19 67.3 0.3 6.6e-19 67.3 0.2 1.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region p450 PF00067.17 ESA14718.1 - 3.1e-62 210.6 0.5 3.6e-62 210.4 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA14719.1 - 0.037 12.5 0.0 0.042 12.3 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.17 ESA14720.1 - 2.4e-52 178.0 0.0 2.8e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1251 PF06856.6 ESA14720.1 - 0.07 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1251) Fungal_trans PF04082.13 ESA14721.1 - 6.3e-15 54.7 0.0 7.2e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain bZIP_2 PF07716.10 ESA14723.1 - 1.9e-06 27.5 14.5 1.9e-06 27.5 10.1 3.7 3 1 1 4 4 4 2 Basic region leucine zipper bZIP_1 PF00170.16 ESA14723.1 - 0.00038 20.3 15.1 0.00038 20.3 10.5 4.1 3 1 2 5 5 5 2 bZIP transcription factor bZIP_Maf PF03131.12 ESA14723.1 - 0.00046 20.4 11.0 0.00046 20.4 7.6 2.5 3 1 0 3 3 3 1 bZIP Maf transcription factor NPV_P10 PF05531.7 ESA14723.1 - 0.043 14.0 0.5 0.12 12.6 0.3 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SUZ PF12752.2 ESA14723.1 - 2.5 8.6 12.8 0.21 12.1 5.1 2.2 2 0 0 2 2 2 0 SUZ domain Biopterin_H PF00351.16 ESA14724.1 - 2.7e-166 552.3 0.0 3.5e-166 551.9 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.20 ESA14724.1 - 6.6e-05 22.2 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 ESA14724.1 - 0.01 16.1 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 ACT domain DUF1638 PF07796.6 ESA14724.1 - 0.15 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1638) BTB PF00651.26 ESA14725.1 - 1.6e-17 63.4 0.1 1.1e-16 60.8 0.0 2.4 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA14725.1 - 1.4e-09 38.0 2.7 9.8e-09 35.3 1.6 2.6 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA14725.1 - 4.2e-07 29.7 0.0 6.1e-06 26.0 0.0 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA14726.1 - 8.5e-17 61.1 0.1 1.9e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA14726.1 - 1.3e-10 41.4 0.3 4.6e-10 39.6 0.2 2.0 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA14726.1 - 2.4e-06 27.3 1.4 1.4e-05 24.8 0.0 2.9 3 1 1 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA14727.1 - 4.6e-18 65.2 1.2 7.2e-18 64.5 0.2 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA14727.1 - 5.2e-07 29.4 0.2 4.6e-06 26.4 0.1 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA14727.1 - 1.2e-06 28.5 1.7 0.059 13.3 0.0 2.7 2 0 0 2 2 2 2 TLD HALZ PF02183.13 ESA14729.1 - 8.5e-06 25.3 4.7 1.6e-05 24.4 0.3 2.3 2 0 0 2 2 2 1 Homeobox associated leucine zipper ERM PF00769.14 ESA14729.1 - 0.0069 15.9 5.3 0.008 15.7 3.7 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.4 ESA14729.1 - 0.014 15.2 6.4 0.017 15.0 4.4 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HOOK PF05622.7 ESA14729.1 - 0.036 11.8 7.9 0.051 11.3 5.5 1.4 1 1 0 1 1 1 0 HOOK protein TPR_MLP1_2 PF07926.7 ESA14729.1 - 0.057 13.1 7.5 0.74 9.5 0.5 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS6_N PF14661.1 ESA14729.1 - 0.061 12.6 4.1 0.063 12.6 2.8 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus bZIP_2 PF07716.10 ESA14729.1 - 0.29 10.9 10.3 0.78 9.6 1.0 2.5 2 1 0 2 2 2 0 Basic region leucine zipper Ax_dynein_light PF10211.4 ESA14729.1 - 0.36 10.6 7.4 0.46 10.2 5.1 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain DUF724 PF05266.9 ESA14729.1 - 1 8.9 6.8 1.1 8.7 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TSC22 PF01166.13 ESA14729.1 - 1.7 8.6 8.0 0.68 9.9 0.4 2.5 1 1 2 3 3 3 0 TSC-22/dip/bun family IncA PF04156.9 ESA14729.1 - 2.3 7.7 8.2 2.7 7.5 5.7 1.1 1 0 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 ESA14729.1 - 3 7.8 6.6 3.2 7.6 4.5 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF972 PF06156.8 ESA14729.1 - 3.8 7.9 7.2 0.76 10.1 1.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF972) RNase_H PF00075.19 ESA14730.1 - 0.00017 21.9 0.2 0.012 16.0 0.0 2.5 1 1 1 2 2 2 1 RNase H DUF3027 PF11228.3 ESA14730.1 - 0.13 11.9 0.0 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) tRNA-synt_1b PF00579.20 ESA14732.1 - 5.3e-77 258.8 0.2 7.1e-77 258.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 ESA14732.1 - 0.063 11.9 0.4 1.1 7.9 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (K) BTB PF00651.26 ESA14736.1 - 0.003 17.5 0.0 0.015 15.2 0.0 2.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4107 PF13389.1 ESA14736.1 - 0.48 10.1 1.8 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4107) FF PF01846.14 ESA14738.1 - 0.0052 16.7 4.2 0.042 13.7 0.8 2.2 1 1 1 2 2 2 2 FF domain Pkinase_Tyr PF07714.12 ESA14740.1 - 5.1e-16 58.5 0.0 8.1e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14740.1 - 1e-12 47.7 0.2 1.8e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA14740.1 - 0.0052 15.8 0.1 0.0082 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Spore_GerQ PF09671.5 ESA14740.1 - 0.13 11.9 1.4 0.47 10.1 0.0 2.7 2 1 1 3 3 3 0 Spore coat protein (Spore_GerQ) zf-RING_2 PF13639.1 ESA14741.1 - 3.1e-10 39.6 2.6 4.6e-10 39.1 1.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA14741.1 - 2.2e-06 27.5 4.4 3.9e-06 26.8 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA14741.1 - 2.2e-06 27.2 1.8 4.5e-06 26.2 1.3 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA14741.1 - 1.2e-05 24.8 1.7 1.8e-05 24.2 1.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA14741.1 - 0.0061 16.2 3.7 0.011 15.4 2.6 1.5 1 1 0 1 1 1 1 zinc-RING finger domain DUF2175 PF09943.4 ESA14741.1 - 0.0092 16.0 3.1 0.014 15.4 2.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2175) RE_LlaMI PF09562.5 ESA14741.1 - 0.018 14.1 0.4 0.027 13.6 0.1 1.4 2 0 0 2 2 2 0 LlaMI restriction endonuclease zf-RING_UBOX PF13445.1 ESA14741.1 - 0.037 13.7 0.3 0.069 12.8 0.2 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 ESA14741.1 - 0.041 13.4 3.7 1.4 8.5 4.0 2.4 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain GAGA PF09237.6 ESA14741.1 - 0.084 12.4 0.6 0.56 9.8 0.0 2.2 2 0 0 2 2 2 0 GAGA factor Prok-RING_1 PF14446.1 ESA14741.1 - 0.1 12.3 4.3 0.19 11.5 0.8 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.3 ESA14741.1 - 0.26 11.2 3.0 0.48 10.4 2.1 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-rbx1 PF12678.2 ESA14741.1 - 0.55 10.3 8.2 1.3 9.1 5.7 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger UPF0547 PF10571.4 ESA14741.1 - 0.56 9.9 4.1 0.78 9.4 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C3HC4_4 PF15227.1 ESA14741.1 - 2.4 8.0 4.9 15 5.5 1.5 2.7 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING Myb_DNA-bind_6 PF13921.1 ESA14742.1 - 0.00037 20.5 0.3 0.00037 20.5 0.2 2.5 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA14742.1 - 0.0033 17.4 2.8 0.44 10.6 0.2 2.5 2 1 0 2 2 2 2 Myb-like DNA-binding domain HgmA PF04209.8 ESA14742.1 - 0.061 11.7 1.0 0.07 11.5 0.7 1.1 1 0 0 1 1 1 0 homogentisate 1,2-dioxygenase Myb_DNA-bind_3 PF12776.2 ESA14742.1 - 3.8 8.2 6.3 1.8 9.2 0.5 2.1 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain BTB PF00651.26 ESA14743.1 - 3.8e-19 68.6 0.0 7.3e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14743.1 - 5.9e-09 35.6 3.2 1.4e-05 24.8 0.1 3.7 4 0 0 4 4 4 2 BTB And C-terminal Kelch Bcl-2 PF00452.14 ESA14743.1 - 0.13 12.3 0.1 0.44 10.6 0.0 2.0 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family IpaB_EvcA PF03278.8 ESA14744.1 - 0.053 12.7 0.2 0.066 12.4 0.1 1.2 1 0 0 1 1 1 0 IpaB/EvcA family TF_AP-2 PF03299.9 ESA14745.1 - 0.084 12.4 2.2 0.082 12.4 1.5 1.1 1 0 0 1 1 1 0 Transcription factor AP-2 Pkinase PF00069.20 ESA14746.1 - 4.1e-21 75.3 0.0 6.3e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14746.1 - 8.2e-21 74.2 0.0 1.1e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA14747.1 - 4.7e-22 78.2 0.0 3.7e-21 75.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14747.1 - 5.4e-22 78.1 0.5 2.3e-21 76.1 0.2 2.3 2 0 0 2 2 2 1 Protein kinase domain HypA PF01155.14 ESA14747.1 - 3.2e-09 36.4 12.7 0.042 13.5 0.5 5.3 5 0 0 5 5 5 5 Hydrogenase expression/synthesis hypA family DUF1657 PF07870.6 ESA14747.1 - 0.12 12.0 0.2 41 3.9 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1657) TraT PF05818.7 ESA14747.1 - 0.37 10.1 10.7 6.4 6.1 0.0 4.6 5 0 0 5 5 5 0 Enterobacterial TraT complement resistance protein SprT-like PF10263.4 ESA14747.1 - 1 9.0 18.3 0.21 11.2 0.2 4.7 5 0 0 5 5 5 0 SprT-like family DUF445 PF04286.7 ESA14747.1 - 1.2 8.6 4.3 12 5.2 0.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF445) zinc_ribbon_2 PF13240.1 ESA14747.1 - 8.1 6.0 41.1 1.6 8.2 0.5 5.8 5 0 0 5 5 5 0 zinc-ribbon domain DUF247 PF03140.10 ESA14749.1 - 0.29 10.1 4.1 4.5 6.1 0.4 2.1 1 1 1 2 2 2 0 Plant protein of unknown function QLQ PF08880.6 ESA14749.1 - 1.6 8.1 5.6 5.1 6.6 0.0 3.4 4 0 0 4 4 4 0 QLQ CitX PF03802.9 ESA14750.1 - 0.053 12.9 0.1 0.085 12.2 0.1 1.2 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Peptidase_M54 PF07998.6 ESA14755.1 - 0.091 12.5 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 Peptidase family M54 DUF885 PF05960.6 ESA14755.1 - 0.096 11.8 0.1 0.12 11.5 0.1 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Pkinase_Tyr PF07714.12 ESA14756.1 - 5.5e-36 123.9 0.0 8.7e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14756.1 - 2.5e-31 108.7 0.0 4.5e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Replicase PF03090.12 ESA14756.1 - 0.039 13.8 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Replicase family DDE_1 PF03184.14 ESA14758.1 - 2.6e-40 137.8 0.1 3.1e-40 137.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA14758.1 - 0.013 15.2 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease PhoPQ_related PF10142.4 ESA14758.1 - 0.018 13.5 0.1 0.024 13.1 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein YbjM PF11045.3 ESA14758.1 - 0.13 12.0 0.0 0.29 10.8 0.0 1.6 1 1 1 2 2 2 0 Putative inner membrane protein of Enterobacteriaceae DUF285 PF03382.9 ESA14759.1 - 0.087 12.3 3.0 0.23 11.0 1.6 2.0 1 1 1 2 2 2 0 Mycoplasma protein of unknown function, DUF285 SCAMP PF04144.8 ESA14759.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 SCAMP family DUF3467 PF11950.3 ESA14759.1 - 0.13 12.3 0.5 0.97 9.4 0.0 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3467) 5_3_exonuc PF01367.15 ESA14759.1 - 1.6 8.9 5.0 7.2 6.9 0.0 3.2 2 1 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold LRS4 PF10422.4 ESA14759.1 - 9.3 5.5 10.4 0.56 9.5 1.0 2.1 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 NEL PF14496.1 ESA14761.1 - 0.067 12.4 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting DUF1473 PF07341.6 ESA14761.1 - 0.088 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1473) DDE_3 PF13358.1 ESA14763.1 - 2.1e-05 24.3 0.1 3.3e-05 23.6 0.1 1.7 1 1 0 1 1 1 1 DDE superfamily endonuclease Ub-RnfH PF03658.9 ESA14766.1 - 0.065 13.1 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 RnfH family Ubiquitin Ubiquitin_2 PF14560.1 ESA14766.1 - 0.067 13.4 0.0 0.082 13.1 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain TLD PF07534.11 ESA14767.1 - 2.1e-09 37.5 1.4 4.6e-09 36.3 1.0 1.6 1 1 0 1 1 1 1 TLD Dimer_Tnp_hAT PF05699.9 ESA14769.1 - 6.1e-21 73.8 0.3 2.1e-19 68.9 0.3 3.2 2 1 0 2 2 2 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA14769.1 - 1.1e-05 25.3 2.1 3e-05 23.9 0.7 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) DDE_1 PF03184.14 ESA14770.1 - 0.027 13.6 0.1 0.042 12.9 0.1 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Pkinase_Tyr PF07714.12 ESA14771.1 - 1.1e-48 165.6 0.0 2.1e-48 164.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14771.1 - 1e-45 155.9 2.2 1e-45 155.9 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Tox-REase-5 PF15648.1 ESA14775.1 - 0.011 16.0 0.2 0.012 15.8 0.1 1.2 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 5 Sel1 PF08238.7 ESA14776.1 - 5.7e-103 335.1 59.1 7.6e-13 48.6 1.0 10.0 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA14776.1 - 3.5e-15 55.3 32.6 0.27 11.7 0.5 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat MIT PF04212.13 ESA14776.1 - 8.9e-07 28.6 30.3 0.16 11.8 0.2 8.1 8 0 0 8 8 8 5 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA14776.1 - 0.0019 17.8 11.7 44 3.9 0.0 7.2 8 0 0 8 8 8 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA14776.1 - 0.0026 17.8 23.4 2.3 8.6 0.2 9.4 9 2 0 9 9 9 2 Tetratricopeptide repeat HTH_16 PF12645.2 ESA14776.1 - 0.82 9.6 6.3 5.3 7.0 0.1 3.8 4 0 0 4 4 4 0 Helix-turn-helix domain DUF2763 PF10961.3 ESA14780.1 - 0.017 15.5 1.4 0.025 14.9 1.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2763) CobT PF06213.7 ESA14780.1 - 0.021 14.0 3.1 0.023 13.8 2.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SpoVR PF04293.8 ESA14780.1 - 0.021 13.2 0.3 0.023 13.1 0.2 1.0 1 0 0 1 1 1 0 SpoVR like protein CDC45 PF02724.9 ESA14780.1 - 0.032 12.2 1.5 0.036 12.1 1.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Glypican PF01153.14 ESA14780.1 - 0.063 11.8 0.2 0.073 11.6 0.1 1.0 1 0 0 1 1 1 0 Glypican Pex14_N PF04695.8 ESA14780.1 - 0.087 12.8 4.5 0.11 12.5 3.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HeLo PF14479.1 ESA14780.1 - 0.096 12.4 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF2428 PF10350.4 ESA14780.1 - 0.097 11.6 0.1 0.11 11.4 0.1 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) Period_C PF12114.3 ESA14780.1 - 0.14 11.7 8.2 0.17 11.4 5.7 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF2201_N PF13203.1 ESA14780.1 - 0.2 10.7 2.3 0.22 10.6 1.6 1.0 1 0 0 1 1 1 0 Putative metallopeptidase domain Apc15p PF05841.6 ESA14780.1 - 1.4 9.6 9.5 1.8 9.2 6.6 1.1 1 0 0 1 1 1 0 Apc15p protein CAF-1_p150 PF11600.3 ESA14780.1 - 6.2 6.1 7.8 8.3 5.7 5.4 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal R3H PF01424.17 ESA14782.1 - 7.9e-17 60.7 0.2 1.8e-16 59.5 0.2 1.7 1 0 0 1 1 1 1 R3H domain SUZ PF12752.2 ESA14782.1 - 1.9e-14 53.9 2.3 3.9e-14 52.9 1.6 1.5 1 0 0 1 1 1 1 SUZ domain Porphobil_deam PF01379.15 ESA14783.1 - 6.3e-85 283.4 0.0 8e-85 283.1 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 ESA14783.1 - 4.6e-18 65.0 0.7 8.6e-18 64.2 0.5 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Mito_carr PF00153.22 ESA14784.1 - 5e-69 228.0 3.1 1.3e-24 85.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Chromate_transp PF02417.10 ESA14784.1 - 0.011 15.3 0.2 0.8 9.2 0.0 2.6 3 0 0 3 3 3 0 Chromate transporter DUF3658 PF12395.3 ESA14784.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function NAC PF01849.13 ESA14785.1 - 2.1e-24 84.7 2.5 6e-24 83.3 0.1 2.6 3 0 0 3 3 3 1 NAC domain UBA PF00627.26 ESA14785.1 - 1.5e-05 24.6 0.4 3.3e-05 23.5 0.3 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Mem_trans PF03547.13 ESA14785.1 - 6.5 4.9 15.3 0.76 8.0 2.9 2.0 2 0 0 2 2 2 0 Membrane transport protein WD40 PF00400.27 ESA14786.1 - 1.6e-18 65.8 18.8 1.3e-05 24.8 0.3 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat eIF2A PF08662.6 ESA14786.1 - 0.0034 17.1 0.0 0.021 14.5 0.0 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 ESA14786.1 - 0.0093 14.2 0.0 0.042 12.1 0.0 2.0 1 1 1 2 2 2 1 Cytochrome D1 heme domain Lactonase PF10282.4 ESA14786.1 - 0.098 11.7 0.0 0.25 10.3 0.0 1.6 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Gtr1_RagA PF04670.7 ESA14787.1 - 1.1e-70 237.4 2.6 1.3e-70 237.1 1.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 ESA14787.1 - 5.1e-06 25.8 0.1 7.6e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA14787.1 - 0.00037 20.4 0.0 0.001 19.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESA14787.1 - 0.00037 20.9 0.1 0.0009 19.7 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 ESA14787.1 - 0.011 14.9 0.2 0.021 14.0 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 ESA14787.1 - 0.02 14.7 0.1 0.051 13.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 ESA14787.1 - 0.059 13.0 0.2 0.25 10.9 0.2 2.0 1 1 0 1 1 1 0 Archaeal ATPase ABC_tran PF00005.22 ESA14788.1 - 0.002 18.4 0.0 0.004 17.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.1 ESA14788.1 - 0.0056 16.5 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 ESA14788.1 - 0.01 15.7 0.0 0.083 12.8 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA14788.1 - 0.021 15.6 0.0 0.037 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 ESA14788.1 - 0.035 13.9 0.1 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Dynamin family RNA_helicase PF00910.17 ESA14788.1 - 0.04 14.0 0.0 0.12 12.5 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.1 ESA14788.1 - 0.068 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Miro PF08477.8 ESA14788.1 - 0.069 13.6 0.1 0.18 12.3 0.1 1.8 1 1 0 1 1 1 0 Miro-like protein MobB PF03205.9 ESA14788.1 - 0.073 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 ESA14788.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Virul_Fac PF10139.4 ESA14788.1 - 0.092 10.6 0.0 0.13 10.1 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor ArgK PF03308.11 ESA14788.1 - 0.1 11.3 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 ArgK protein DNA_pol_B_thumb PF14791.1 ESA14789.1 - 1.4e-20 72.6 0.0 3e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 ESA14789.1 - 2.4e-15 55.8 1.1 3.8e-15 55.1 0.1 1.9 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 ESA14789.1 - 7.4e-14 51.6 0.1 6.6e-13 48.6 0.2 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.1 ESA14789.1 - 1e-13 51.3 0.0 3.2e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase beta palm NTP_transf_2 PF01909.18 ESA14789.1 - 0.0026 18.0 0.0 0.0059 16.9 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain IMS_HHH PF11798.3 ESA14789.1 - 0.092 12.8 0.4 20 5.4 0.0 2.8 2 0 0 2 2 2 0 IMS family HHH motif RRM_1 PF00076.17 ESA14791.1 - 1.5e-08 34.1 0.2 0.0015 18.1 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA14791.1 - 3.1e-08 33.4 0.5 0.0011 18.9 0.0 3.6 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA14791.1 - 8e-05 22.4 0.0 0.098 12.5 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA14791.1 - 0.057 13.2 0.5 0.88 9.3 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif zf-CCHC PF00098.18 ESA14791.1 - 0.071 13.0 4.1 0.2 11.6 2.8 1.8 1 0 0 1 1 1 0 Zinc knuckle CD99L2 PF12301.3 ESA14791.1 - 0.41 10.3 4.4 0.08 12.6 0.3 1.8 2 0 0 2 2 2 0 CD99 antigen like protein 2 Exo_endo_phos_2 PF14529.1 ESA14792.1 - 4.8e-08 32.6 0.7 1.3e-07 31.2 0.5 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA14792.1 - 2.4e-07 30.9 0.1 5.2e-07 29.8 0.1 1.7 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ubiquitin_2 PF14560.1 ESA14792.1 - 0.0081 16.3 0.2 0.022 15.0 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain DUF640 PF04852.7 ESA14792.1 - 0.36 11.0 1.7 1.5 9.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF640) ADH_zinc_N PF00107.21 ESA14794.1 - 5.8e-19 67.9 0.0 9.5e-19 67.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA14794.1 - 0.00014 22.7 0.0 0.00028 21.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Phyto_Pns9_10 PF05878.6 ESA14795.1 - 0.00028 19.9 0.1 0.00037 19.6 0.0 1.1 1 0 0 1 1 1 1 Phytoreovirus nonstructural protein Pns9/Pns10 ADH_zinc_N PF00107.21 ESA14795.1 - 0.015 14.8 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF2315 PF10231.4 ESA14795.1 - 0.067 13.0 0.1 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) CBM_20 PF00686.14 ESA14796.1 - 0.00039 19.9 0.1 0.0012 18.3 0.0 1.9 1 0 0 1 1 1 1 Starch binding domain Fes1 PF08609.5 ESA14797.1 - 0.065 13.7 0.2 0.12 12.9 0.1 1.5 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Snf7 PF03357.16 ESA14797.1 - 0.12 11.7 2.4 0.17 11.2 1.7 1.1 1 0 0 1 1 1 0 Snf7 SlyX PF04102.7 ESA14799.1 - 0.0039 17.5 4.7 0.0049 17.2 1.9 2.2 1 1 1 2 2 2 1 SlyX SWI-SNF_Ssr4 PF08549.5 ESA14799.1 - 0.012 13.9 3.1 0.15 10.3 0.8 2.1 1 1 1 2 2 2 0 Fungal domain of unknown function (DUF1750) FemAB PF02388.11 ESA14799.1 - 0.17 10.5 2.5 0.26 9.9 1.8 1.2 1 0 0 1 1 1 0 FemAB family DivIC PF04977.10 ESA14799.1 - 1.9 8.0 4.9 2.4 7.7 2.4 1.9 1 1 1 2 2 2 0 Septum formation initiator SRPRB PF09439.5 ESA14800.1 - 1.2e-45 154.9 0.1 1.6e-45 154.5 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 ESA14800.1 - 4e-17 62.0 0.0 6e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA14800.1 - 7.2e-07 28.8 0.3 1.1e-05 24.9 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA14800.1 - 6e-06 26.2 0.0 1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 ESA14800.1 - 9.3e-06 26.1 0.0 1.9e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein ATP_bind_1 PF03029.12 ESA14800.1 - 0.0002 20.9 0.1 0.00084 18.9 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.15 ESA14800.1 - 0.011 14.5 1.5 2 6.9 0.2 2.4 1 1 1 2 2 2 0 G-protein alpha subunit DUF929 PF06053.6 ESA14800.1 - 0.043 12.8 1.2 0.6 9.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF929) Tmemb_cc2 PF10267.4 ESA14800.1 - 0.079 11.5 0.4 0.25 9.8 0.4 1.7 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DUF4064 PF13273.1 ESA14800.1 - 2.6 8.2 5.3 2.4 8.3 2.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) RRM_1 PF00076.17 ESA14801.1 - 2.9e-16 58.8 0.0 4.8e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA14801.1 - 1.1e-12 47.7 0.0 1.7e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA14801.1 - 7.8e-09 35.2 0.1 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3602 PF12223.3 ESA14801.1 - 0.072 13.4 0.5 0.16 12.4 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3602) Dus PF01207.12 ESA14802.1 - 1.1e-73 247.8 0.0 1.3e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Oxidored_FMN PF00724.15 ESA14802.1 - 5e-05 22.4 0.1 8.3e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family TMP-TENI PF02581.12 ESA14802.1 - 0.0027 16.8 0.0 0.0055 15.8 0.0 1.5 2 0 0 2 2 2 1 Thiamine monophosphate synthase/TENI His_biosynth PF00977.16 ESA14802.1 - 0.0046 16.2 0.0 0.0079 15.4 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein DHO_dh PF01180.16 ESA14802.1 - 0.012 14.5 0.2 0.65 8.9 0.2 2.2 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase NanE PF04131.9 ESA14802.1 - 0.022 13.7 0.0 0.033 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase DUF561 PF04481.7 ESA14802.1 - 0.027 13.4 0.1 0.047 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Eaf7 PF07904.8 ESA14802.1 - 0.11 12.4 0.1 0.34 10.9 0.1 1.8 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 IMPDH PF00478.20 ESA14802.1 - 0.15 10.8 0.1 0.23 10.3 0.1 1.3 1 1 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Prenyltrans PF00432.16 ESA14803.1 - 1.3e-65 216.5 7.6 5.7e-13 48.1 0.0 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESA14803.1 - 2.5e-37 127.7 0.0 1.7e-17 63.8 0.0 3.9 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESA14803.1 - 2.2e-13 50.1 0.0 3.8e-06 26.8 0.0 3.4 2 1 2 4 4 4 3 Prenyltransferase-like MtrA PF04208.9 ESA14803.1 - 0.054 12.9 0.0 0.34 10.3 0.0 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit A Sad1_UNC PF07738.8 ESA14804.1 - 2.2e-29 101.9 0.0 7.1e-16 58.2 0.0 2.6 1 1 0 2 2 2 2 Sad1 / UNC-like C-terminal SpoVIF PF14069.1 ESA14804.1 - 0.032 13.9 0.3 0.11 12.2 0.2 1.9 1 0 0 1 1 1 0 Stage VI sporulation protein F 7TM_GPCR_Sri PF10327.4 ESA14805.1 - 0.014 14.4 2.0 0.13 11.2 1.2 2.1 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sri Glyco_transf_20 PF00982.16 ESA14806.1 - 1.1e-193 644.0 0.0 1.3e-193 643.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.15 ESA14806.1 - 0.16 11.3 0.6 14 5.1 0.1 2.9 2 1 0 2 2 2 0 Glycosyl transferases group 1 Pkinase_Tyr PF07714.12 ESA14807.1 - 1.1e-41 142.6 0.0 1.4e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14807.1 - 1.5e-37 129.1 0.1 2.4e-37 128.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA14807.1 - 0.062 13.0 0.0 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDE_1 PF03184.14 ESA14808.1 - 1.5e-34 119.0 1.8 1.7e-34 118.8 1.3 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-TFIIIC PF12660.2 ESA14808.1 - 0.054 13.3 0.1 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex BTB_2 PF02214.17 ESA14809.1 - 6.6e-17 61.4 0.0 4.1e-16 58.9 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain RNR_inhib PF08591.5 ESA14809.1 - 0.13 13.1 3.8 0.4 11.6 2.6 1.9 1 0 0 1 1 1 0 Ribonucleotide reductase inhibitor HPS3_C PF14763.1 ESA14813.1 - 0.026 13.4 0.5 0.036 13.0 0.3 1.3 1 1 0 1 1 1 0 Hermansky-Pudlak syndrome 3, C-terminal DUF4446 PF14584.1 ESA14813.1 - 0.066 13.0 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) NPV_P10 PF05531.7 ESA14813.1 - 0.071 13.3 0.1 0.2 11.9 0.0 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein KRTDAP PF15200.1 ESA14815.1 - 1.9 8.3 4.8 3.7 7.3 0.1 3.0 3 1 1 4 4 4 0 Keratinocyte differentiation-associated PSRP-3_Ycf65 PF04839.8 ESA14819.1 - 0.024 14.7 1.0 5.1 7.2 0.0 3.4 3 0 0 3 3 3 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) bPH_4 PF06713.6 ESA14819.1 - 0.2 11.5 3.9 8.6 6.3 0.2 2.9 2 1 1 3 3 3 0 Bacterial PH domain YadA_head PF05658.9 ESA14821.1 - 2.1 8.7 4.7 24 5.3 0.0 2.7 3 1 0 3 3 3 0 Head domain of trimeric autotransporter adhesin zf-CCHC PF00098.18 ESA14822.1 - 0.0022 17.8 3.8 0.0044 16.8 2.6 1.5 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.3 ESA14822.1 - 0.005 16.7 11.1 0.018 14.9 7.8 1.8 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G TauD PF02668.11 ESA14824.1 - 2.8e-11 43.5 0.8 1.2e-10 41.4 0.0 1.9 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family Baculo_PEP_C PF04513.7 ESA14825.1 - 0.1 12.3 2.5 2.4 8.0 0.4 2.9 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ACDC PF14733.1 ESA14825.1 - 0.85 9.7 5.4 0.94 9.6 1.0 2.8 2 0 0 2 2 2 0 AP2-coincident C-terminal Pribosyltran PF00156.22 ESA14826.1 - 1.8e-06 27.6 0.2 3.8e-05 23.4 0.1 2.2 1 1 0 1 1 1 1 Phosphoribosyl transferase domain GN3L_Grn1 PF08701.6 ESA14827.1 - 1.9e-19 69.3 20.1 1.9e-19 69.3 14.0 2.0 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 ESA14827.1 - 2.3e-19 69.4 0.4 9.7e-14 51.3 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA14827.1 - 5.6e-09 35.4 0.1 5.4e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESA14827.1 - 1.6e-05 24.4 3.1 0.00028 20.3 0.1 3.4 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESA14827.1 - 0.00065 19.5 4.2 0.42 10.4 0.2 3.9 2 2 1 3 3 3 1 Dynamin family DUF258 PF03193.11 ESA14827.1 - 0.0076 15.4 0.0 0.019 14.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA14827.1 - 0.012 16.4 1.9 0.088 13.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain Miro PF08477.8 ESA14827.1 - 0.03 14.8 1.6 2.2 8.7 0.0 3.1 3 1 0 3 3 3 0 Miro-like protein Bromodomain PF00439.20 ESA14828.1 - 5.7e-22 77.4 0.9 1.7e-21 75.9 0.6 1.9 1 0 0 1 1 1 1 Bromodomain DUF3512 PF12024.3 ESA14828.1 - 2.8e-08 33.3 0.0 2.8e-08 33.3 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3512) HSDR_N_2 PF13588.1 ESA14829.1 - 0.085 12.6 0.0 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DAP3 PF10236.4 ESA14831.1 - 9.6e-09 34.5 0.3 5.2e-07 28.8 0.0 3.0 2 1 0 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 IstB_IS21 PF01695.12 ESA14831.1 - 6.6e-05 22.4 0.1 0.00037 19.9 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESA14831.1 - 0.0016 18.3 0.0 0.26 11.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA14831.1 - 0.0025 18.1 0.1 0.018 15.3 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA14831.1 - 0.0042 17.2 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESA14831.1 - 0.0066 16.6 0.2 0.03 14.5 0.1 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESA14831.1 - 0.0085 15.5 0.0 0.02 14.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA14831.1 - 0.036 14.8 0.4 0.31 11.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain PhoH PF02562.11 ESA14831.1 - 0.12 11.5 0.2 0.46 9.6 0.0 2.0 3 0 0 3 3 3 0 PhoH-like protein F-box-like PF12937.2 ESA14832.1 - 8.2e-05 22.2 4.4 0.00023 20.8 3.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA14832.1 - 0.099 12.3 1.2 0.31 10.7 0.8 1.9 1 0 0 1 1 1 0 F-box domain Glyco_transf_49 PF13896.1 ESA14834.1 - 3.4e-27 95.3 1.6 2.1e-19 69.7 0.1 2.2 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_tranf_2_2 PF10111.4 ESA14834.1 - 0.0028 16.7 0.1 0.0044 16.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 APG9 PF04109.11 ESA14835.1 - 0.0057 15.6 1.9 0.72 8.6 0.2 2.1 2 0 0 2 2 2 2 Autophagy protein Apg9 MHC_I PF00129.13 ESA14836.1 - 0.0036 16.6 4.2 0.043 13.1 0.5 2.3 1 1 0 2 2 2 2 Class I Histocompatibility antigen, domains alpha 1 and 2 DUF3024 PF11225.3 ESA14836.1 - 0.27 11.1 4.3 2.5 8.0 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3024) DUF1104 PF06518.6 ESA14837.1 - 0.0076 16.3 0.7 0.0076 16.3 0.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1104) DUF2652 PF10851.3 ESA14837.1 - 0.084 12.8 0.3 0.13 12.2 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2652) DUF1268 PF06896.6 ESA14837.1 - 0.49 10.7 5.7 1.2 9.4 3.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1268) RhaA PF06134.6 ESA14839.1 - 0.14 11.0 0.0 0.16 10.8 0.0 1.0 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) Pkinase PF00069.20 ESA14841.1 - 4.7e-15 55.4 0.5 1.5e-10 40.7 0.2 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14841.1 - 2e-08 33.6 0.3 1.7e-06 27.3 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Galactosyl_T PF01762.16 ESA14842.1 - 3e-08 33.4 0.3 2.1e-07 30.7 0.1 1.9 1 1 1 2 2 2 1 Galactosyltransferase DUF3016 PF11454.3 ESA14842.1 - 0.11 12.0 0.1 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) DUF3912 PF13051.1 ESA14844.1 - 0.017 14.8 0.0 0.064 13.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3912) Pkinase_Tyr PF07714.12 ESA14845.1 - 0.11 11.4 0.1 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase SRP-alpha_N PF04086.8 ESA14846.1 - 9.2e-50 169.5 14.1 2.3e-49 168.2 9.8 1.6 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal Hom_end_hint PF05203.11 ESA14846.1 - 3.2e-31 108.7 0.0 1e-30 107.0 0.0 1.9 1 0 0 1 1 1 1 Hom_end-associated Hint SRP54_N PF02881.14 ESA14846.1 - 2e-08 34.2 0.1 6.5e-08 32.5 0.1 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain SRP54 PF00448.17 ESA14846.1 - 2.5e-08 33.5 0.1 4.5e-07 29.4 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Hint_2 PF13403.1 ESA14846.1 - 0.0019 18.1 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Hint domain Hint PF01079.15 ESA14846.1 - 0.028 13.6 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 Hint module Dimer_Tnp_hAT PF05699.9 ESA14848.1 - 4.4e-12 45.4 0.0 4.7e-12 45.3 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sel1 PF08238.7 ESA14849.1 - 1.8e-29 101.4 6.3 1.1e-10 41.8 0.0 3.7 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.1 ESA14849.1 - 0.0052 17.1 0.2 0.23 12.0 0.0 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA14849.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain TPR_11 PF13414.1 ESA14849.1 - 0.47 10.1 5.0 3.6 7.3 0.4 3.0 2 1 1 3 3 3 0 TPR repeat TPR_1 PF00515.23 ESA14849.1 - 1 9.0 10.8 1.6 8.5 0.3 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA14850.1 - 2.4e-10 39.9 0.1 2.7e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14850.1 - 4.5e-09 35.8 0.1 5.2e-09 35.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain GMC_oxred_C PF05199.8 ESA14851.1 - 5.5e-36 124.0 0.0 6.2e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase Pkinase_Tyr PF07714.12 ESA14852.1 - 3.6e-08 32.8 0.0 4.4e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14852.1 - 0.002 17.3 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF2597 PF10772.4 ESA14854.1 - 0.069 13.0 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2597) FliD_C PF07195.7 ESA14855.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.0 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Pkinase_Tyr PF07714.12 ESA14859.1 - 5.9e-14 51.7 0.7 4.8e-09 35.6 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA14859.1 - 2.3e-12 46.6 0.4 1.5e-06 27.5 0.0 2.5 2 1 1 3 3 3 2 Protein kinase domain GAS PF13851.1 ESA14859.1 - 0.0064 15.7 9.6 0.014 14.6 6.7 1.6 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESA14859.1 - 0.02 14.4 4.4 0.028 14.0 3.1 1.2 1 0 0 1 1 1 0 IncA protein Shugoshin_N PF07558.6 ESA14859.1 - 0.037 13.7 3.2 0.037 13.7 2.3 2.3 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region V_ATPase_I PF01496.14 ESA14859.1 - 0.17 9.7 5.0 0.21 9.3 3.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cluap1 PF10234.4 ESA14859.1 - 0.22 10.6 6.6 0.32 10.1 4.6 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 XH PF03469.9 ESA14859.1 - 0.24 11.0 3.3 0.82 9.3 0.0 2.7 1 1 2 3 3 3 0 XH domain DUF972 PF06156.8 ESA14859.1 - 0.54 10.6 8.9 1 9.7 4.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FliT PF05400.8 ESA14859.1 - 0.6 10.5 7.0 16 5.9 4.7 2.4 1 1 0 1 1 1 0 Flagellar protein FliT Rootletin PF15035.1 ESA14859.1 - 2.3 8.1 11.6 7.9 6.4 8.0 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion RVT_1 PF00078.22 ESA14860.1 - 2e-08 33.8 0.1 0.00012 21.4 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) F-box-like PF12937.2 ESA14861.1 - 0.00036 20.1 2.7 0.00037 20.1 0.8 1.8 2 0 0 2 2 2 1 F-box-like INSIG PF07281.7 ESA14862.1 - 1.8e-10 40.4 0.0 3.2e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) LRR_8 PF13855.1 ESA14864.1 - 0.31 10.8 10.5 0.63 9.8 0.1 4.1 4 1 0 4 4 4 0 Leucine rich repeat DUF2660 PF10859.3 ESA14864.1 - 0.71 10.1 7.5 10 6.3 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2660) An_peroxidase PF03098.10 ESA14865.1 - 1e-90 304.6 0.0 1.5e-90 304.1 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase DOMON PF03351.12 ESA14865.1 - 2e-12 47.1 0.9 3.8e-12 46.2 0.2 1.8 2 0 0 2 2 2 1 DOMON domain DUF2427 PF10348.4 ESA14865.1 - 0.029 13.9 0.2 0.063 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) WAK_assoc PF14380.1 ESA14865.1 - 0.26 11.7 0.0 5.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal DUF221 PF02714.10 ESA14866.1 - 3e-87 292.5 20.6 5.7e-87 291.6 14.3 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 ESA14866.1 - 1e-48 164.8 0.9 1e-48 164.8 0.6 2.7 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport DUF4463 PF14703.1 ESA14866.1 - 5.3e-09 36.4 0.1 9.4e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Histone PF00125.19 ESA14869.1 - 0.29 11.3 2.1 2.5 8.3 0.0 2.7 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 YCII PF03795.9 ESA14870.1 - 2e-10 40.7 0.0 2.8e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Apc3 PF12895.2 ESA14870.1 - 0.11 12.6 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 F-box-like PF12937.2 ESA14873.1 - 0.00073 19.2 0.7 0.0022 17.6 0.5 1.7 1 0 0 1 1 1 1 F-box-like MIR PF02815.14 ESA14874.1 - 0.00062 19.3 0.1 0.29 10.6 0.0 2.4 1 1 1 2 2 2 2 MIR domain Pkinase PF00069.20 ESA14875.1 - 0.00022 20.4 3.7 0.00025 20.2 0.3 2.4 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14875.1 - 0.0003 19.9 0.0 0.0003 19.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2118 PF09891.4 ESA14875.1 - 0.05 13.3 0.2 0.098 12.3 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) HypA PF01155.14 ESA14875.1 - 0.099 12.3 2.3 0.16 11.6 1.6 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family U3_assoc_6 PF08640.6 ESA14875.1 - 0.2 11.4 2.4 0.35 10.6 0.0 2.4 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 Cytochrome_C7 PF14522.1 ESA14875.1 - 0.46 10.1 5.4 0.89 9.2 3.7 1.5 1 0 0 1 1 1 0 Cytochrome c7 XPA_N PF01286.13 ESA14875.1 - 0.86 9.3 5.5 9.8 5.9 0.2 2.3 2 0 0 2 2 2 0 XPA protein N-terminal DZR PF12773.2 ESA14875.1 - 7.3 6.4 8.2 27 4.6 5.8 1.6 1 1 0 1 1 1 0 Double zinc ribbon Prok_Ub PF14454.1 ESA14876.1 - 0.068 12.8 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DUF4123 PF13503.1 ESA14876.1 - 0.12 12.2 0.1 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) HSP70 PF00012.15 ESA14877.1 - 0.0011 17.0 0.0 0.0016 16.4 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.15 ESA14877.1 - 0.039 13.2 0.0 0.05 12.8 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family RSD-2 PF07547.8 ESA14877.1 - 0.045 13.8 0.1 0.39 10.8 0.0 2.2 2 0 0 2 2 2 0 RSD-2 N-terminal domain EMG1 PF03587.9 ESA14877.1 - 0.081 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase MreB_Mbl PF06723.8 ESA14877.1 - 0.12 10.9 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein PUF PF00806.14 ESA14877.1 - 0.15 11.5 0.6 17 5.1 0.0 3.3 3 0 0 3 3 3 0 Pumilio-family RNA binding repeat Peptidase_M22 PF00814.20 ESA14877.1 - 0.18 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycoprotease family MreB_Mbl PF06723.8 ESA14878.1 - 3.8e-06 25.7 0.0 0.064 11.8 0.0 2.4 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA14878.1 - 7.3e-05 20.8 1.2 0.0005 18.1 0.8 2.3 1 1 0 1 1 1 1 Hsp70 protein Stn1_C PF12659.2 ESA14878.1 - 0.063 13.0 3.5 0.22 11.3 1.1 2.5 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH CTK3 PF12243.3 ESA14878.1 - 0.079 12.5 0.9 0.34 10.5 0.1 2.2 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 IZUMO PF15005.1 ESA14878.1 - 0.22 11.5 5.4 0.08 12.9 1.9 1.6 2 0 0 2 2 2 0 Izumo sperm-egg fusion DUF605 PF04652.11 ESA14879.1 - 1.4 8.1 12.7 1.5 8.1 8.8 1.0 1 0 0 1 1 1 0 Vta1 like TLD PF07534.11 ESA14881.1 - 2.6e-12 46.9 2.1 6e-12 45.7 1.5 1.6 1 1 0 1 1 1 1 TLD DSPc PF00782.15 ESA14883.1 - 2.7e-12 46.4 0.0 5e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain BTB PF00651.26 ESA14884.1 - 3.3e-19 68.9 0.3 6.9e-19 67.8 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA14884.1 - 1.9e-16 60.3 2.2 6.6e-16 58.5 1.5 2.0 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA14884.1 - 1.7e-06 27.7 4.6 0.0089 15.8 0.5 3.5 1 1 2 3 3 3 3 BTB And C-terminal Kelch Na_Ca_ex PF01699.19 ESA14885.1 - 3.4e-24 85.0 30.3 1.1e-15 57.4 6.7 3.7 2 2 2 4 4 4 3 Sodium/calcium exchanger protein ATP-synt_8 PF00895.15 ESA14885.1 - 0.18 12.0 0.1 0.18 12.0 0.1 5.0 5 1 1 6 6 6 0 ATP synthase protein 8 FBP PF07299.6 ESA14886.1 - 0.012 15.0 0.4 0.013 14.8 0.3 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein (FBP) RGS PF00615.14 ESA14886.1 - 0.046 13.8 1.9 0.053 13.6 1.3 1.3 1 0 0 1 1 1 0 Regulator of G protein signaling domain HXXSHH PF07586.6 ESA14886.1 - 0.13 11.1 0.1 0.17 10.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Med28 PF11594.3 ESA14886.1 - 0.14 12.3 1.0 0.24 11.6 0.6 1.4 1 1 0 1 1 1 0 Mediator complex subunit 28 NAGLU_C PF12972.2 ESA14887.1 - 0.14 11.5 0.2 0.16 11.3 0.2 1.0 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain Cys_rich_VLP PF14194.1 ESA14889.1 - 0.016 14.9 0.3 0.047 13.4 0.2 1.7 1 0 0 1 1 1 0 Cysteine-rich VLP FAR1 PF03101.10 ESA14890.1 - 1.2e-06 28.8 5.6 3.1e-06 27.6 3.9 1.6 1 1 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA14890.1 - 4.4e-06 26.1 0.4 0.073 12.6 0.0 2.5 2 0 0 2 2 2 2 MuDR family transposase Bet_v_1 PF00407.14 ESA14890.1 - 0.055 13.0 3.5 0.11 12.1 0.2 2.6 1 1 2 3 3 3 0 Pathogenesis-related protein Bet v I family Cys_rich_VLP PF14194.1 ESA14891.1 - 0.0023 17.6 0.5 0.0049 16.5 0.4 1.5 1 0 0 1 1 1 1 Cysteine-rich VLP MULE PF10551.4 ESA14891.1 - 0.012 15.7 0.1 0.038 14.1 0.0 1.8 1 0 0 1 1 1 0 MULE transposase domain Transposase_mut PF00872.13 ESA14891.1 - 0.026 13.0 0.0 0.038 12.5 0.0 1.2 1 0 0 1 1 1 0 Transposase, Mutator family YagB_YeeU_YfjZ PF06154.6 ESA14891.1 - 0.07 13.3 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 YagB/YeeU/YfjZ family TIP49 PF06068.8 ESA14892.1 - 0.038 12.7 0.2 0.051 12.2 0.1 1.1 1 0 0 1 1 1 0 TIP49 C-terminus Ribosomal_L36e PF01158.13 ESA14892.1 - 0.038 13.9 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L36e Pkinase_Tyr PF07714.12 ESA14893.1 - 0.021 13.9 0.0 0.029 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase YyzF PF14116.1 ESA14893.1 - 0.023 14.6 0.1 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 YyzF-like protein Pkinase PF00069.20 ESA14893.1 - 0.044 12.9 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Glyco_hydro_32C PF08244.7 ESA14894.1 - 0.076 13.4 0.5 0.23 11.8 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 C terminal DUF4411 PF14367.1 ESA14894.1 - 0.84 9.3 7.0 0.18 11.4 0.7 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4411) zf-RING_5 PF14634.1 ESA14896.1 - 0.022 14.4 9.8 0.022 14.4 6.8 1.8 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.1 ESA14896.1 - 0.91 9.4 14.2 0.043 13.6 5.8 1.9 2 0 0 2 2 2 0 Ring finger domain Pkinase_Tyr PF07714.12 ESA14897.1 - 1.8e-36 125.5 0.0 2.1e-36 125.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14897.1 - 5.7e-31 107.6 0.0 6.9e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA14897.1 - 3.8e-05 22.8 0.2 5.3e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA14897.1 - 0.00057 18.9 0.0 0.00073 18.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA14897.1 - 0.0015 18.3 0.1 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PIP49_C PF12260.3 ESA14897.1 - 0.017 14.5 0.1 0.026 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 PsbU PF06514.6 ESA14897.1 - 0.028 14.2 0.0 0.16 11.7 0.0 2.1 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) RIO1 PF01163.17 ESA14897.1 - 0.031 13.6 0.1 0.049 12.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 ESA14897.1 - 0.047 13.2 0.5 0.075 12.5 0.3 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF3567 PF12091.3 ESA14898.1 - 0.013 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) SCA7 PF08313.7 ESA14899.1 - 1.4e-25 88.7 4.9 1.4e-25 88.7 3.4 2.1 1 1 1 2 2 2 1 SCA7, zinc-binding domain GNVR PF13807.1 ESA14899.1 - 0.042 13.5 0.3 0.077 12.7 0.2 1.6 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase RasGEF_N PF00618.15 ESA14899.1 - 1 9.4 6.4 0.11 12.6 0.9 1.8 1 1 1 2 2 2 0 RasGEF N-terminal motif Salp15 PF12115.3 ESA14900.1 - 0.016 15.4 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Pkinase_Tyr PF07714.12 ESA14904.1 - 9.8e-24 83.8 0.1 1.6e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14904.1 - 1.8e-20 73.2 4.1 6.3e-20 71.4 2.3 2.2 2 1 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA14904.1 - 0.0013 18.4 0.2 0.0033 17.1 0.2 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA14904.1 - 0.0075 15.3 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Spore_coat_CotO PF14153.1 ESA14904.1 - 0.043 13.2 0.1 0.095 12.1 0.1 1.6 1 1 0 1 1 1 0 Spore coat protein CotO M20_dimer PF07687.9 ESA14906.1 - 1.4e-08 34.4 0.1 2.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESA14906.1 - 4.7e-07 29.4 0.0 1.3e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 zf-C2H2 PF00096.21 ESA14907.1 - 5.8e-13 48.3 9.7 1.3e-06 28.3 1.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA14907.1 - 1.8e-10 40.3 7.0 3.4e-06 26.9 0.8 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA14907.1 - 2.9e-10 39.8 12.1 1.5e-07 31.3 0.5 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-met PF12874.2 ESA14907.1 - 7.7e-06 25.9 1.3 7.7e-06 25.9 0.9 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESA14907.1 - 5e-05 23.3 4.3 0.00018 21.5 0.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESA14907.1 - 0.012 15.4 0.7 0.012 15.4 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.1 ESA14907.1 - 0.029 14.0 3.3 4.3 7.1 0.0 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Di19 PF05605.7 ESA14907.1 - 0.065 13.3 1.8 0.13 12.3 1.2 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 ESA14907.1 - 0.099 12.4 5.5 1.3 8.8 3.8 2.3 1 1 0 1 1 1 0 BED zinc finger GAGA PF09237.6 ESA14907.1 - 7.9 6.1 6.2 7.1 6.3 0.1 2.9 1 1 2 3 3 3 0 GAGA factor TLD PF07534.11 ESA14908.1 - 7.7e-13 48.6 0.1 1e-12 48.2 0.1 1.2 1 0 0 1 1 1 1 TLD zf-BED PF02892.10 ESA14910.1 - 3e-07 30.1 3.0 7e-07 28.9 2.1 1.7 1 0 0 1 1 1 1 BED zinc finger HSP70 PF00012.15 ESA14912.1 - 7.6e-187 621.9 9.9 1.3e-105 353.6 2.6 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA14912.1 - 2.9e-08 32.6 0.4 0.00016 20.3 0.0 3.2 3 0 0 3 3 3 2 MreB/Mbl protein DUF1464 PF07318.7 ESA14912.1 - 0.018 13.8 0.0 0.051 12.3 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1464) Hydantoinase_A PF01968.13 ESA14912.1 - 0.076 12.1 1.2 1 8.4 0.1 2.5 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase CPSF73-100_C PF11718.3 ESA14913.1 - 0.0097 15.2 5.1 0.014 14.7 3.5 1.1 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term SurA_N_2 PF13623.1 ESA14913.1 - 0.024 14.6 0.5 0.024 14.6 0.3 1.6 2 0 0 2 2 2 0 SurA N-terminal domain CUE PF02845.11 ESA14913.1 - 0.043 13.3 0.1 0.11 12.0 0.1 1.7 1 0 0 1 1 1 0 CUE domain RNA_pol_Rpb1_5 PF04998.12 ESA14913.1 - 0.26 10.5 2.7 0.26 10.5 1.9 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 PFEMP PF03011.10 ESA14913.1 - 0.37 11.1 11.8 0.025 14.9 4.0 1.9 2 0 0 2 2 2 0 PFEMP DBL domain DUF295 PF03478.13 ESA14914.1 - 0.0086 15.4 0.1 0.023 14.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF295) zf-BED PF02892.10 ESA14915.1 - 0.003 17.2 8.0 0.21 11.3 5.5 2.5 1 1 0 1 1 1 1 BED zinc finger DUF310 PF03750.8 ESA14915.1 - 0.11 12.7 1.6 4.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF310) HSP70 PF00012.15 ESA14920.1 - 1.1e-15 56.6 0.0 1.2e-15 56.5 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein HALZ PF02183.13 ESA14921.1 - 3e-06 26.8 5.6 3e-06 26.8 3.9 3.8 3 0 0 3 3 3 2 Homeobox associated leucine zipper Phage_GP20 PF06810.6 ESA14921.1 - 0.0026 17.2 43.8 0.015 14.6 12.6 3.1 1 1 1 2 2 2 2 Phage minor structural protein GP20 DUF972 PF06156.8 ESA14921.1 - 0.017 15.4 12.5 0.017 15.4 8.7 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF972) Cluap1 PF10234.4 ESA14921.1 - 0.13 11.3 26.3 0.33 10.1 18.2 1.6 1 0 0 1 1 1 0 Clusterin-associated protein-1 ADIP PF11559.3 ESA14921.1 - 0.16 11.9 40.4 0.38 10.6 8.8 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.2 ESA14921.1 - 0.21 11.4 42.7 0.14 11.9 27.6 2.2 1 1 1 2 2 2 0 Tropomyosin like Spc7 PF08317.6 ESA14921.1 - 0.24 10.0 47.4 0.044 12.4 26.5 2.7 3 1 0 3 3 3 0 Spc7 kinetochore protein DUF3584 PF12128.3 ESA14921.1 - 0.4 7.9 34.6 0.57 7.4 24.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CCDC-167 PF15188.1 ESA14921.1 - 0.91 9.5 27.0 4.6 7.2 6.8 3.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 TBPIP PF07106.8 ESA14921.1 - 1.4 8.3 45.5 0.036 13.6 16.0 3.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) AAA_27 PF13514.1 ESA14921.1 - 3.2 5.3 23.1 4.3 4.8 16.0 1.1 1 0 0 1 1 1 0 AAA domain Tnp_P_element PF12017.3 ESA14921.1 - 3.4 6.8 19.3 23 4.0 7.4 3.3 2 1 1 3 3 3 0 Transposase protein UPF0075 PF03702.9 ESA14921.1 - 4.6 6.0 7.5 0.97 8.2 0.0 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0075) Reo_sigmaC PF04582.7 ESA14921.1 - 7.1 5.6 9.7 1.2 8.2 4.0 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TLD PF07534.11 ESA14922.1 - 3.1e-11 43.4 1.6 5.4e-11 42.6 1.1 1.4 1 0 0 1 1 1 1 TLD DnaI_N PF07319.6 ESA14922.1 - 0.0012 19.0 0.0 0.0037 17.4 0.0 1.9 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus RasGEF_N PF00618.15 ESA14922.1 - 0.039 14.0 1.6 0.057 13.5 0.1 2.0 2 0 0 2 2 2 0 RasGEF N-terminal motif HSP70 PF00012.15 ESA14923.1 - 6.8e-10 37.4 0.1 7e-10 37.4 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Sel1 PF08238.7 ESA14924.1 - 7.2e-15 55.0 7.7 2.8e-09 37.2 0.2 3.1 3 0 0 3 3 3 2 Sel1 repeat Pec_lyase PF09492.5 ESA14924.1 - 0.025 13.7 1.5 1.6 7.8 0.1 2.0 1 1 1 2 2 2 0 Pectic acid lyase Fucose_iso_N2 PF07882.7 ESA14924.1 - 0.31 10.6 1.8 1.2 8.7 1.3 1.7 1 1 0 1 1 1 0 L-fucose isomerase, second N-terminal domain TPR_2 PF07719.12 ESA14924.1 - 0.65 10.0 4.7 7 6.8 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA14924.1 - 0.85 9.3 5.6 32 4.3 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TLD PF07534.11 ESA14926.1 - 3.6e-13 49.6 3.4 6.5e-13 48.8 2.3 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA14926.1 - 0.018 14.8 3.6 0.053 13.3 0.3 3.0 1 1 2 3 3 3 0 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA14927.1 - 0.057 12.4 0.1 0.16 11.0 0.1 1.7 1 1 1 2 2 2 0 Protein tyrosine kinase DUF3078 PF11276.3 ESA14927.1 - 0.17 12.0 2.0 1.3 9.2 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3078) Pkinase_Tyr PF07714.12 ESA14928.1 - 0.071 12.1 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1033 PF06279.6 ESA14929.1 - 0.14 11.9 4.0 0.11 12.3 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1033) HMG_box PF00505.14 ESA14930.1 - 1.3e-07 31.7 0.0 2.7e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA14930.1 - 0.0014 18.9 0.0 0.0027 18.0 0.0 1.5 1 1 0 1 1 1 1 HMG-box domain Rubrerythrin PF02915.12 ESA14931.1 - 0.0066 16.7 0.3 0.011 16.0 0.2 1.3 1 1 0 1 1 1 1 Rubrerythrin LRR_8 PF13855.1 ESA14934.1 - 0.81 9.4 10.7 1.5 8.6 1.3 3.2 2 1 1 3 3 3 0 Leucine rich repeat LRR_7 PF13504.1 ESA14934.1 - 1 9.8 5.7 27 5.5 0.1 4.2 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 ESA14934.1 - 2.9 7.5 11.3 1.1 8.9 1.4 3.6 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) DUF1358 PF07096.6 ESA14935.1 - 2.4e-07 30.4 0.0 3.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) Acetyltransf_1 PF00583.19 ESA14936.1 - 4.3e-08 33.0 0.0 5.5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA14936.1 - 4.6e-07 29.9 0.0 6.7e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA14936.1 - 8.6e-07 29.0 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA14936.1 - 0.00036 20.2 0.0 0.00053 19.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 ESA14936.1 - 0.005 16.6 0.2 0.087 12.6 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain LRR_4 PF12799.2 ESA14938.1 - 1.9e-06 27.3 10.1 0.31 10.7 0.0 6.1 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA14938.1 - 4.3e-05 23.1 9.6 3.8 7.8 0.1 7.2 8 1 0 8 8 8 2 Leucine Rich repeat F-box-like PF12937.2 ESA14938.1 - 0.00025 20.6 0.0 0.00064 19.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA14938.1 - 0.015 15.0 13.5 3.1 7.6 0.8 5.5 4 2 1 5 5 5 0 Leucine rich repeat Paf67 PF10255.4 ESA14939.1 - 1.5e-168 560.8 3.2 2.2e-168 560.3 2.2 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.12 ESA14939.1 - 0.00069 19.3 0.0 0.0044 16.8 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA14939.1 - 0.0038 16.7 0.1 0.021 14.4 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TLD PF07534.11 ESA14940.1 - 5.6e-12 45.8 2.9 9.9e-12 45.0 2.0 1.4 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA14940.1 - 0.00022 21.2 0.1 0.00048 20.1 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA14940.1 - 0.0073 16.1 1.9 0.032 14.0 1.3 2.2 1 1 0 1 1 1 1 BTB And C-terminal Kelch Gly_transf_sug PF04488.10 ESA14941.1 - 2.1e-09 37.6 0.2 4.6e-09 36.5 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 ESA14941.1 - 5.1e-06 25.8 0.1 9.4e-06 24.9 0.0 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 ESA14941.1 - 7.3e-05 21.4 0.0 9.6e-05 21.0 0.0 1.2 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain DUF3369 PF11849.3 ESA14942.1 - 0.034 14.1 0.6 0.073 13.0 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3369) Agro_virD5 PF04730.7 ESA14942.1 - 0.044 11.8 0.0 0.05 11.6 0.0 1.1 1 0 0 1 1 1 0 Agrobacterium VirD5 protein Pkinase_Tyr PF07714.12 ESA14943.1 - 7.5e-41 139.9 0.1 1e-40 139.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14943.1 - 1.1e-36 126.3 1.4 1.8e-36 125.6 1.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA14943.1 - 0.00012 21.2 0.0 0.00019 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA14943.1 - 0.17 11.6 0.1 6.4 6.4 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_C39_2 PF13529.1 ESA14944.1 - 0.28 11.5 2.0 2.9 8.2 0.1 2.6 1 1 1 2 2 2 0 Peptidase_C39 like family STAT_int PF02865.12 ESA14944.1 - 0.48 10.3 4.4 0.44 10.5 0.7 2.3 1 1 1 2 2 2 0 STAT protein, protein interaction domain Orthopox_B11R PF07033.6 ESA14945.1 - 0.013 15.0 2.6 0.04 13.3 1.8 1.8 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Pox_VERT_large PF04441.8 ESA14945.1 - 0.017 13.2 0.4 0.023 12.9 0.3 1.1 1 0 0 1 1 1 0 Poxvirus early transcription factor (VETF), large subunit Pkinase_Tyr PF07714.12 ESA14946.1 - 5.1e-15 55.2 0.0 3.6e-11 42.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA14946.1 - 2.2e-14 53.2 0.8 2.4e-06 26.9 0.2 2.5 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA14946.1 - 0.2 11.3 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Chitin_synth_2 PF03142.10 ESA14947.1 - 1.4e-175 584.6 5.1 1.7e-175 584.4 3.5 1.0 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA14947.1 - 2.6e-17 63.1 0.4 2.6e-17 63.1 0.3 2.2 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA14947.1 - 9.4e-15 55.0 0.0 1.5e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 ESA14947.1 - 3.6e-06 26.3 0.0 0.0054 16.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 ESA14947.1 - 0.03 14.0 0.0 0.074 12.7 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 BTB PF00651.26 ESA14948.1 - 0.011 15.6 0.0 0.047 13.6 0.0 1.8 1 1 1 2 2 2 0 BTB/POZ domain DNApol3-delta_C PF09115.5 ESA14948.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal Poxvirus_B22R_N PF13169.1 ESA14948.1 - 0.12 12.6 0.9 0.16 12.2 0.6 1.1 1 0 0 1 1 1 0 Poxvirus B22R protein N-terminal S_locus_glycop PF00954.15 ESA14950.1 - 0.22 11.7 1.0 0.3 11.3 0.7 1.1 1 0 0 1 1 1 0 S-locus glycoprotein family TLD PF07534.11 ESA14951.1 - 7.4e-11 42.1 0.8 1.2e-10 41.5 0.6 1.3 1 0 0 1 1 1 1 TLD RasGEF_N PF00618.15 ESA14951.1 - 0.091 12.8 1.7 0.22 11.6 1.2 1.7 1 1 0 1 1 1 0 RasGEF N-terminal motif DUF3942 PF13078.1 ESA14951.1 - 1.2 9.1 7.3 0.35 10.9 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3942) TFIIS_M PF07500.9 ESA14951.1 - 2.3 8.2 5.5 0.21 11.6 0.7 1.6 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS), central domain FAD_binding_4 PF01565.18 ESA14952.1 - 2.3e-22 78.9 0.5 1e-21 76.8 0.7 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.7 ESA14952.1 - 9.5e-06 25.4 0.0 2.3e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like C2 PF00168.25 ESA14953.1 - 7.7e-45 150.6 0.1 8.4e-17 60.8 0.0 3.4 3 0 0 3 3 3 3 C2 domain DUF2404 PF10296.4 ESA14953.1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Putative integral membrane protein conserved region (DUF2404) F-box-like PF12937.2 ESA14954.1 - 4.6e-05 23.0 2.6 0.00022 20.8 0.8 2.6 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 ESA14954.1 - 0.01 15.5 6.0 0.3 10.8 0.4 4.4 4 1 1 5 5 5 0 Leucine rich repeat LRR_4 PF12799.2 ESA14954.1 - 1.2 8.8 9.0 2.5 7.8 0.5 4.4 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.12 ESA14955.1 - 8.5e-32 110.2 0.0 9.7e-32 110.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14955.1 - 1.2e-30 106.5 0.1 1.4e-30 106.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA14955.1 - 0.00031 19.8 0.0 0.00038 19.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA14955.1 - 0.00035 19.9 0.0 0.00045 19.6 0.0 1.1 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA14955.1 - 0.0022 17.2 0.0 0.003 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA14955.1 - 0.024 14.3 0.1 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA14955.1 - 0.032 13.1 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Big_5 PF13205.1 ESA14959.1 - 0.0084 16.7 1.1 0.027 15.0 0.2 2.2 2 0 0 2 2 2 1 Bacterial Ig-like domain VEFS-Box PF09733.4 ESA14960.1 - 10 5.7 13.0 8.7 6.0 7.3 1.8 1 1 1 2 2 2 0 VEFS-Box of polycomb protein DUF2847 PF11009.3 ESA14961.1 - 0.039 13.5 0.4 0.044 13.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) UN_NPL4 PF11543.3 ESA14961.1 - 0.13 12.5 0.6 0.13 12.5 0.4 1.1 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 ISK_Channel PF02060.10 ESA14961.1 - 0.14 11.7 0.1 0.16 11.5 0.1 1.1 1 0 0 1 1 1 0 Slow voltage-gated potassium channel DIX PF00778.12 ESA14963.1 - 0.033 13.9 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 DIX domain Pkinase PF00069.20 ESA14965.1 - 4.1e-21 75.3 0.0 7e-21 74.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA14965.1 - 7.9e-20 71.0 0.0 1.1e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 ESA14965.1 - 0.044 13.3 0.8 0.47 9.9 0.1 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase APH PF01636.18 ESA14965.1 - 0.05 13.3 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA14966.1 - 5.7e-12 45.2 0.2 1.9e-11 43.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA14966.1 - 7e-09 35.2 0.1 1.7e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF1462 PF07315.6 ESA14967.1 - 0.053 13.4 0.2 0.72 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1462) Inhibitor_I34 PF10466.4 ESA14968.1 - 0.15 12.1 0.9 0.19 11.8 0.5 1.4 1 1 0 1 1 1 0 Saccharopepsin inhibitor I34 Mpv17_PMP22 PF04117.7 ESA14970.1 - 0.071 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Mpv17 / PMP22 family LRR_8 PF13855.1 ESA14973.1 - 0.0003 20.4 4.9 0.065 12.9 0.2 3.3 3 0 0 3 3 3 2 Leucine rich repeat DUF3092 PF11289.3 ESA14973.1 - 0.023 13.9 0.8 0.037 13.2 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3092) GMC_oxred_N PF00732.14 ESA14974.1 - 1.5e-31 109.6 0.0 2.1e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ESA14974.1 - 0.00012 21.1 0.0 0.00015 20.8 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 ESA14974.1 - 0.00091 18.2 0.0 0.0016 17.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA14974.1 - 0.0061 16.5 0.0 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESA14974.1 - 0.044 12.8 0.0 0.097 11.7 0.0 1.5 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.9 ESA14974.1 - 0.1 12.4 0.1 0.15 11.8 0.1 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AAA_25 PF13481.1 ESA14978.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESA14978.1 - 0.025 14.0 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain AAA_14 PF13173.1 ESA14978.1 - 0.035 14.0 0.0 0.3 10.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain Thr_synth_N PF14821.1 ESA14978.1 - 0.046 13.7 0.4 11 6.1 0.1 3.1 3 0 0 3 3 3 0 Threonine synthase N terminus Pox_A32 PF04665.7 ESA14978.1 - 0.063 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein ERCC4 PF02732.10 ESA14978.1 - 0.097 12.4 0.0 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 ERCC4 domain zf-C4H2 PF10146.4 ESA14978.1 - 0.14 12.2 0.1 3 7.8 0.0 2.0 2 0 0 2 2 2 0 Zinc finger-containing protein T2SE PF00437.15 ESA14978.1 - 0.16 10.8 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AIG1 PF04548.11 ESA14979.1 - 6.6e-31 107.0 0.2 6.6e-31 107.0 0.1 2.5 2 1 1 3 3 3 1 AIG1 family Hint PF01079.15 ESA14979.1 - 5.3e-22 78.0 0.0 1.1e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Hint module MMR_HSR1 PF01926.18 ESA14979.1 - 1.7e-10 40.8 0.1 1.7e-10 40.8 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA14979.1 - 1.7e-05 24.0 0.0 5.2e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 ESA14979.1 - 2e-05 23.9 0.0 4.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.1 ESA14979.1 - 0.00067 19.9 0.1 0.00067 19.9 0.1 3.5 2 1 0 2 2 1 1 AAA domain Miro PF08477.8 ESA14979.1 - 0.00068 20.1 0.0 0.0031 18.0 0.0 2.2 1 1 0 1 1 1 1 Miro-like protein ABC_tran PF00005.22 ESA14979.1 - 0.00069 19.9 0.6 0.00069 19.9 0.4 2.7 2 2 0 2 2 2 1 ABC transporter SRPRB PF09439.5 ESA14979.1 - 0.00097 18.4 0.2 0.00097 18.4 0.1 1.8 2 0 0 2 2 1 1 Signal recognition particle receptor beta subunit RNA_helicase PF00910.17 ESA14979.1 - 0.0017 18.4 0.0 0.0049 17.0 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.1 ESA14979.1 - 0.0049 17.0 2.2 0.0071 16.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 ESA14979.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.1 ESA14979.1 - 0.012 15.6 0.2 0.044 13.7 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 ESA14979.1 - 0.026 14.0 0.1 0.05 13.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 ESA14979.1 - 0.049 12.5 0.3 0.1 11.5 0.2 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 ESA14979.1 - 0.062 13.3 0.3 0.33 10.9 0.0 2.3 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_14 PF13173.1 ESA14979.1 - 0.076 12.9 0.1 0.076 12.9 0.1 2.8 2 1 0 2 2 1 0 AAA domain AAA_5 PF07728.9 ESA14979.1 - 0.1 12.3 0.5 0.44 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESA14979.1 - 0.12 13.1 0.0 0.12 13.1 0.0 3.7 2 2 0 2 2 1 0 AAA domain Dynamin_N PF00350.18 ESA14979.1 - 0.15 11.8 0.0 0.15 11.8 0.0 4.2 2 2 1 3 3 2 0 Dynamin family AAA PF00004.24 ESA14979.1 - 0.15 12.2 4.4 0.23 11.6 0.0 2.8 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.4 ESA14979.1 - 0.17 11.3 1.0 0.52 9.7 0.7 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 ESA14979.1 - 0.43 9.9 0.0 0.43 9.9 0.0 2.3 2 2 0 3 3 2 0 Elongation factor Tu GTP binding domain DUF3810 PF12725.2 ESA14979.1 - 0.58 9.0 5.4 1.6 7.5 3.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) DinB PF05163.7 ESA14979.1 - 0.79 9.4 5.3 1.6 8.4 1.4 2.5 2 1 1 3 3 3 0 DinB family AAA_24 PF13479.1 ESA14979.1 - 0.82 9.2 7.8 8.5 5.8 0.3 3.8 4 1 0 4 4 4 0 AAA domain BTB PF00651.26 ESA14980.1 - 5.4e-07 29.5 0.8 9e-06 25.6 0.5 2.5 1 1 0 1 1 1 1 BTB/POZ domain SPC12 PF06645.8 ESA14980.1 - 0.12 12.1 0.1 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) TPPII_N PF12583.3 ESA14983.1 - 0.1 12.7 0.4 17 5.5 0.0 2.2 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal Sel1 PF08238.7 ESA14984.1 - 2.1e-83 272.9 26.1 4.1e-11 43.1 0.6 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_7 PF13176.1 ESA14984.1 - 0.00019 21.0 5.4 4.7 7.2 0.0 5.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA14984.1 - 0.0026 17.3 21.5 0.61 9.7 2.1 5.9 4 1 1 5 5 5 4 TPR repeat MIR PF02815.14 ESA14985.1 - 0.006 16.1 0.1 0.01 15.3 0.1 1.4 1 0 0 1 1 1 1 MIR domain Viral_helicase1 PF01443.13 ESA14986.1 - 0.26 10.7 1.9 9.5 5.6 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF4119 PF13494.1 ESA14987.1 - 0.042 13.8 0.2 14 5.7 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) SH3_9 PF14604.1 ESA14990.1 - 2.6e-07 30.1 0.1 3.1e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 ESA14990.1 - 6.6e-07 28.6 0.0 1.3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA14990.1 - 2.6e-05 23.5 0.0 5.3e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Variant SH3 domain DUF1517 PF07466.6 ESA14992.1 - 0.036 13.0 0.0 0.038 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) UPF0233 PF06781.7 ESA14992.1 - 0.35 10.5 1.6 7.2 6.3 1.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0233) Polysacc_deac_1 PF01522.16 ESA14993.1 - 4.3e-35 120.0 0.0 8e-35 119.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA14993.1 - 0.0013 17.7 0.3 0.0063 15.4 0.1 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 Peptidase_C48 PF02902.14 ESA14994.1 - 5.6e-20 71.8 1.4 2e-19 70.0 1.0 1.9 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C39 PF03412.10 ESA14994.1 - 0.065 13.0 0.1 0.28 10.9 0.0 2.0 2 1 0 2 2 2 0 Peptidase C39 family Sel1 PF08238.7 ESA14995.1 - 2.1e-66 218.9 26.5 4.8e-10 39.7 0.3 9.1 9 0 0 9 9 9 9 Sel1 repeat End_N_terminal PF12218.3 ESA14995.1 - 0.0023 17.3 0.3 0.029 13.8 0.1 2.8 3 1 0 4 4 4 1 N terminal extension of bacteriophage endosialidase MIT PF04212.13 ESA14995.1 - 0.0052 16.6 21.0 0.26 11.2 1.1 5.5 4 1 1 5 5 5 2 MIT (microtubule interacting and transport) domain AdoMet_MTase PF07757.8 ESA14995.1 - 0.029 14.4 1.3 2 8.5 0.0 3.8 4 1 1 5 5 5 0 Predicted AdoMet-dependent methyltransferase DUF2553 PF10830.3 ESA14995.1 - 0.68 10.4 11.9 15 6.1 0.2 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2553) CTV_P13 PF06922.6 ESA14996.1 - 0.02 14.7 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 Citrus tristeza virus P13 protein Sel1 PF08238.7 ESA14997.1 - 6.1e-265 849.9 110.9 7.7e-12 45.4 0.0 28.0 28 0 0 28 28 28 27 Sel1 repeat TPR_6 PF13174.1 ESA14997.1 - 1.5e-07 31.4 20.5 5.3 7.7 0.0 14.5 15 1 1 16 16 16 1 Tetratricopeptide repeat Synaptobrevin PF00957.16 ESA14999.1 - 0.01 15.4 1.5 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Synaptobrevin Innexin PF00876.13 ESA14999.1 - 0.021 13.9 0.4 0.036 13.1 0.3 1.4 1 0 0 1 1 1 0 Innexin Prominin PF05478.6 ESA14999.1 - 0.029 11.9 0.0 0.27 8.7 0.0 2.0 2 0 0 2 2 2 0 Prominin Pkinase PF00069.20 ESA15001.1 - 2e-06 27.1 0.1 2.4e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15001.1 - 1.7e-05 24.0 0.0 2.3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DDE_1 PF03184.14 ESA15002.1 - 2.7e-30 105.1 0.3 7.5e-16 57.9 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease CENP-B_N PF04218.8 ESA15002.1 - 0.012 15.0 0.6 0.051 12.9 0.0 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain LRR_8 PF13855.1 ESA15003.1 - 0.0012 18.5 5.4 0.2 11.4 0.3 3.3 3 0 0 3 3 3 2 Leucine rich repeat DUF3092 PF11289.3 ESA15003.1 - 0.023 13.9 0.8 0.037 13.2 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3092) Rsd_AlgQ PF04353.8 ESA15005.1 - 0.0015 18.2 1.1 0.0017 18.0 0.8 1.1 1 0 0 1 1 1 1 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Muted PF14942.1 ESA15005.1 - 0.012 15.5 2.3 0.015 15.1 1.6 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein MutS_III PF05192.13 ESA15005.1 - 0.017 14.8 0.2 0.021 14.6 0.1 1.1 1 0 0 1 1 1 0 MutS domain III CCDC155 PF14662.1 ESA15005.1 - 0.032 13.8 2.7 0.037 13.6 1.9 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Tht1 PF04163.7 ESA15005.1 - 0.058 11.7 0.5 0.061 11.7 0.4 1.1 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein Endotoxin_N PF03945.9 ESA15005.1 - 0.068 12.5 0.7 0.082 12.2 0.5 1.1 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain DUF1640 PF07798.6 ESA15005.1 - 0.077 13.0 3.7 0.1 12.6 2.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF692 PF05114.8 ESA15005.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF692) T_Ag_DNA_bind PF02217.11 ESA15005.1 - 0.12 12.8 0.4 2.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Origin of replication binding protein PIF1 PF05970.9 ESA15005.1 - 0.14 11.0 1.0 0.15 10.9 0.7 1.1 1 0 0 1 1 1 0 PIF1-like helicase DUF904 PF06005.7 ESA15005.1 - 0.21 11.9 3.5 0.4 11.0 2.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Syntaxin PF00804.20 ESA15005.1 - 0.27 11.4 4.1 3.5 7.8 2.8 2.1 1 1 0 1 1 1 0 Syntaxin Seryl_tRNA_N PF02403.17 ESA15005.1 - 0.29 11.1 3.3 0.4 10.7 2.3 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Pinin_SDK_memA PF04696.8 ESA15005.1 - 0.3 10.6 3.6 0.36 10.4 2.5 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Phage_T7_tail PF03906.9 ESA15006.1 - 0.06 12.9 0.0 0.083 12.5 0.0 1.1 1 0 0 1 1 1 0 Phage T7 tail fibre protein DDRGK PF09756.4 ESA15007.1 - 0.018 14.4 5.7 0.022 14.1 4.0 1.0 1 0 0 1 1 1 0 DDRGK domain GN3L_Grn1 PF08701.6 ESA15007.1 - 0.14 12.1 6.0 0.22 11.4 4.1 1.4 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase Sel1 PF08238.7 ESA15008.1 - 6e-60 198.3 7.7 2.2e-09 37.6 0.0 7.1 7 0 0 7 7 7 7 Sel1 repeat Vhr1 PF04001.8 ESA15008.1 - 0.00034 20.4 0.1 0.72 9.8 0.0 2.5 2 0 0 2 2 2 2 Transcription factor Vhr1 MIT PF04212.13 ESA15008.1 - 0.0029 17.4 4.4 1.5 8.7 0.0 5.1 5 1 1 6 6 6 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA15008.1 - 0.68 9.6 12.1 9.6 5.9 0.0 4.5 3 1 3 6 6 6 0 TPR repeat NSF PF02071.15 ESA15008.1 - 2.7 8.9 8.4 2 9.3 0.3 4.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat DUF4435 PF14491.1 ESA15009.1 - 0.0026 17.6 2.8 0.27 11.0 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF4435) LRR_4 PF12799.2 ESA15010.1 - 7.9e-39 130.6 45.1 5.8e-09 35.3 0.3 6.7 6 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA15010.1 - 2.3e-22 78.5 62.0 1e-07 31.5 3.0 5.7 1 1 7 8 8 8 7 Leucine rich repeat LRR_9 PF14580.1 ESA15010.1 - 2.2e-14 53.3 17.7 1.3e-06 28.1 0.1 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.28 ESA15010.1 - 2.3e-12 45.1 38.4 0.39 10.9 0.2 10.8 11 1 1 12 12 12 6 Leucine Rich Repeat LRR_7 PF13504.1 ESA15010.1 - 3.4e-08 32.4 15.2 6.7 7.3 0.2 10.0 7 2 1 8 8 8 2 Leucine rich repeat LRR_6 PF13516.1 ESA15010.1 - 1.6e-06 27.5 26.5 3.7 7.9 0.0 10.6 3 2 6 9 9 9 2 Leucine Rich repeat PPR_2 PF13041.1 ESA15011.1 - 2.9e-66 219.2 29.9 2.8e-11 43.1 0.0 11.1 4 3 7 11 11 11 10 PPR repeat family PPR PF01535.15 ESA15011.1 - 4.1e-46 151.7 32.7 5e-06 26.1 0.0 11.7 11 1 0 11 11 11 11 PPR repeat PPR_3 PF13812.1 ESA15011.1 - 5.6e-43 141.6 0.0 6.2e-06 26.0 0.0 11.2 11 0 0 11 11 11 6 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA15011.1 - 1.4e-39 133.2 23.4 3.2e-08 32.9 0.0 11.3 10 2 0 10 10 10 8 PPR repeat TPR_19 PF14559.1 ESA15011.1 - 5.8e-06 26.5 0.1 2.7 8.3 0.0 4.2 5 0 0 5 5 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA15011.1 - 1.4e-05 25.0 5.8 0.047 13.8 0.4 5.0 3 1 3 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 Ribonuc_red_lgN PF00317.16 ESA15011.1 - 2.4e-05 24.0 4.9 1.8 8.4 0.0 5.0 4 1 0 4 4 3 3 Ribonucleotide reductase, all-alpha domain TPR_2 PF07719.12 ESA15011.1 - 3.3e-05 23.4 5.1 1.1 9.3 0.1 7.3 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15011.1 - 0.00013 22.5 0.0 1.8 9.3 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat SPOB_a PF14689.1 ESA15011.1 - 0.00035 20.0 5.9 1.7 8.3 0.1 5.3 6 0 0 6 6 6 1 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_8 PF13181.1 ESA15011.1 - 0.00061 19.3 15.5 11 6.0 0.1 7.9 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA15011.1 - 0.00064 20.0 8.1 11 6.7 0.0 7.8 9 0 0 9 9 8 0 Tetratricopeptide repeat ECSIT PF06239.6 ESA15011.1 - 0.0016 17.3 0.3 0.0016 17.3 0.2 4.4 3 1 2 6 6 6 1 Evolutionarily conserved signalling intermediate in Toll pathway TPPII_N PF12583.3 ESA15011.1 - 0.0019 18.3 1.2 2.4 8.2 0.1 3.2 3 0 0 3 3 3 1 Tripeptidyl peptidase II N terminal DUF823 PF05689.6 ESA15011.1 - 0.0097 15.2 0.2 0.014 14.7 0.1 1.2 1 0 0 1 1 1 1 Salmonella repeat of unknown function (DUF823) Cas_Cas02710 PF09670.5 ESA15011.1 - 0.085 11.4 1.2 4.6 5.7 0.1 3.0 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) TPR_1 PF00515.23 ESA15011.1 - 0.5 10.0 15.7 14 5.4 0.1 7.4 10 0 0 10 10 10 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA15013.1 - 0.00059 19.5 1.1 0.0014 18.3 0.7 1.6 1 0 0 1 1 1 1 F-box-like MucB_RseB PF03888.9 ESA15013.1 - 0.028 13.4 0.0 0.049 12.6 0.0 1.3 1 0 0 1 1 1 0 MucB/RseB family LRR_8 PF13855.1 ESA15013.1 - 4.8 7.0 12.9 0.98 9.2 0.2 4.1 4 1 0 4 4 4 0 Leucine rich repeat AAA_12 PF13087.1 ESA15014.1 - 1.8e-36 125.4 1.3 6.8e-36 123.5 0.9 2.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA15014.1 - 2.1e-25 89.6 2.5 2.1e-25 89.6 1.7 2.8 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA15014.1 - 4.1e-05 23.2 0.0 8.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA15014.1 - 4.2e-05 22.6 8.5 0.00018 20.5 0.0 3.5 4 0 0 4 4 4 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESA15014.1 - 0.00067 19.2 0.0 0.056 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA15014.1 - 0.026 14.5 0.1 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 ESA15014.1 - 0.032 14.3 0.0 0.79 9.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESA15014.1 - 0.033 14.3 0.4 0.21 11.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) XdhC_C PF13478.1 ESA15014.1 - 0.17 12.1 0.0 5 7.4 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain AAA_12 PF13087.1 ESA15015.1 - 2.6e-34 118.3 0.1 2.6e-34 118.3 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA15015.1 - 2.7e-23 82.7 7.8 5.1e-21 75.3 5.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA15015.1 - 8.5e-05 22.2 0.0 0.00022 20.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA15015.1 - 0.00042 19.3 9.4 0.021 13.7 0.0 3.9 3 1 1 4 4 4 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.1 ESA15015.1 - 0.0085 15.6 0.0 2.8 7.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESA15015.1 - 0.043 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ResIII PF04851.10 ESA15015.1 - 0.062 13.1 0.2 0.062 13.1 0.1 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA PF00004.24 ESA15015.1 - 3.3 7.9 11.7 0.8 9.9 0.5 3.8 2 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.1 ESA15017.1 - 5.5e-36 123.8 1.8 1.4e-35 122.5 1.3 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA15017.1 - 1.7e-12 47.4 0.1 1.7e-12 47.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.1 ESA15019.1 - 2.5e-35 121.6 10.3 7.5e-35 120.1 1.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.1 ESA15019.1 - 2.3e-12 47.0 19.6 5.6e-10 39.1 10.6 3.5 2 1 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 ESA15019.1 - 0.0045 17.0 1.2 0.024 14.7 0.0 2.5 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain HMG_box PF00505.14 ESA15020.1 - 1.8e-07 31.3 0.0 2.9e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA15020.1 - 0.069 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 HMG-box domain Sel1 PF08238.7 ESA15022.1 - 1.9e-91 298.4 16.3 1.3e-10 41.5 0.1 9.0 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA15022.1 - 6.6e-06 26.2 1.3 1 9.9 0.0 5.8 6 1 0 6 6 6 1 Tetratricopeptide repeat IR1-M PF12185.3 ESA15022.1 - 0.14 11.8 2.2 16 5.2 0.0 4.5 6 0 0 6 6 6 0 Nup358/RanBP2 E3 ligase domain Zn_ribbon_2 PF12674.2 ESA15022.1 - 6.4 7.1 12.9 0.77 10.1 0.7 4.5 5 1 1 6 6 6 0 Putative zinc ribbon domain Pkinase_Tyr PF07714.12 ESA15023.1 - 0.083 11.9 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Cut8_N PF14482.1 ESA15023.1 - 0.39 10.7 3.3 5 7.2 0.1 2.5 1 1 1 2 2 2 0 Cut8 proteasome-binding domain FYRC PF05965.9 ESA15024.1 - 0.038 13.8 0.1 1.2 9.0 0.0 3.0 2 2 0 2 2 2 0 F/Y rich C-terminus Pkinase_Tyr PF07714.12 ESA15025.1 - 2.9e-35 121.5 0.0 3.3e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15025.1 - 2.7e-32 111.9 0.1 3e-32 111.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA15025.1 - 0.00066 18.7 0.0 0.00093 18.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA15025.1 - 0.00079 19.2 0.1 0.00097 18.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA15025.1 - 0.0031 16.6 0.1 0.0043 16.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA15025.1 - 0.056 12.7 0.1 0.078 12.3 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Sel1 PF08238.7 ESA15026.1 - 2.3e-101 330.0 14.3 5.2e-10 39.6 0.0 10.1 10 0 0 10 10 10 10 Sel1 repeat Cytomega_US3 PF05963.6 ESA15026.1 - 0.012 14.9 0.5 26 4.0 0.0 4.8 4 2 2 6 6 6 0 Cytomegalovirus US3 protein End3 PF12761.2 ESA15026.1 - 0.15 11.7 1.7 28 4.2 0.0 3.6 2 1 2 4 4 4 0 Actin cytoskeleton-regulatory complex protein END3 Voltage_CLC PF00654.15 ESA15028.1 - 7.1e-96 321.3 27.0 7.1e-96 321.3 18.7 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 ESA15028.1 - 4.9e-13 48.6 0.2 2.5e-08 33.5 0.0 2.6 2 0 0 2 2 2 2 CBS domain AMP-binding PF00501.23 ESA15029.1 - 7.5e-22 77.2 0.0 9.5e-22 76.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme BTB PF00651.26 ESA15032.1 - 7.5e-17 61.3 0.9 1.6e-16 60.2 0.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15032.1 - 1.3e-11 44.7 2.7 1.3e-11 44.7 1.9 2.1 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA15033.1 - 1.3e-15 57.3 0.1 3.5e-15 55.9 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA15033.1 - 7.5e-09 35.3 0.4 5.1e-06 26.2 0.0 3.4 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ESA15033.1 - 1.3e-06 28.4 1.4 1.3e-06 28.4 1.0 1.8 2 0 0 2 2 2 1 TLD LAGLIDADG_WhiA PF14527.1 ESA15033.1 - 0.12 12.2 0.5 0.55 10.1 0.1 2.4 2 1 0 2 2 2 0 WhiA LAGLIDADG-like domain Sel1 PF08238.7 ESA15036.1 - 2.9e-100 326.5 28.3 9.6e-12 45.1 0.3 12.1 12 0 0 12 12 12 12 Sel1 repeat MIT PF04212.13 ESA15036.1 - 0.0025 17.6 25.7 4.5 7.2 0.1 7.9 7 2 1 8 8 8 2 MIT (microtubule interacting and transport) domain HisK_N PF09385.5 ESA15036.1 - 0.0083 15.7 1.2 2.4 7.7 0.0 3.0 2 1 1 3 3 3 2 Histidine kinase N terminal DUF2989 PF11207.3 ESA15036.1 - 0.065 12.6 16.7 1.4 8.3 0.0 5.1 2 1 3 5 5 5 0 Protein of unknown function (DUF2989) HTH_40 PF14493.1 ESA15036.1 - 0.4 10.9 2.3 16 5.8 0.0 3.7 3 1 0 3 3 3 0 Helix-turn-helix domain RVT_1 PF00078.22 ESA15037.1 - 6.6e-12 45.2 0.0 8.9e-11 41.5 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.22 ESA15038.1 - 1.5e-10 40.7 0.0 5.9e-10 38.8 0.0 2.0 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) SpoVG PF04026.7 ESA15038.1 - 0.013 15.5 0.1 0.039 13.9 0.1 1.8 1 0 0 1 1 1 0 SpoVG DNA_pol3_beta_3 PF02768.10 ESA15038.1 - 0.14 11.7 2.3 1.6 8.2 0.6 2.3 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain Chordopox_A15 PF05846.7 ESA15038.1 - 0.49 10.4 4.9 3.6 7.7 0.2 2.8 1 1 3 4 4 4 0 Chordopoxvirus A15 protein CPSase_L_D2 PF02786.12 ESA15039.1 - 8.9e-77 257.1 0.0 1.3e-76 256.5 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 ESA15039.1 - 7.8e-34 116.0 0.1 1.7e-33 115.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 ESA15039.1 - 1.2e-31 108.8 0.0 2.1e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 ESA15039.1 - 1.6e-18 67.1 0.1 2.8e-18 66.3 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 ESA15039.1 - 3.3e-18 65.5 0.0 1.8e-17 63.1 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 ESA15039.1 - 1.4e-09 37.6 0.0 2.8e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.6 ESA15039.1 - 2e-08 33.9 0.0 4.5e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp PF02222.17 ESA15039.1 - 6.3e-07 28.9 0.0 1.2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 ESA15039.1 - 8.5e-05 22.4 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain MetW PF07021.7 ESA15040.1 - 0.0049 16.2 0.0 0.0065 15.8 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.1 ESA15040.1 - 0.017 15.4 0.0 0.031 14.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 ESA15040.1 - 0.021 14.4 0.2 0.083 12.4 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESA15040.1 - 0.042 14.3 0.0 0.083 13.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 ESA15040.1 - 0.075 13.6 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 ESA15040.1 - 0.095 11.7 0.0 0.61 9.1 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DDE_1 PF03184.14 ESA15041.1 - 1.1e-26 93.3 0.6 1.6e-25 89.4 0.1 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA15041.1 - 2.8e-05 23.8 0.1 6.5e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF1706 PF08020.6 ESA15041.1 - 0.024 14.1 2.1 2.2 7.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1706) Pkinase PF00069.20 ESA15044.1 - 1.4e-18 66.9 0.0 1.8e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15044.1 - 2.6e-18 66.0 0.0 5.4e-18 64.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Laminin_EGF PF00053.19 ESA15044.1 - 0.02 14.8 1.2 0.043 13.7 0.9 1.5 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) PRK PF00485.13 ESA15046.1 - 7.5e-19 68.0 0.0 1.1e-17 64.1 0.0 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 ESA15046.1 - 1.1e-08 35.4 0.7 2.1e-08 34.5 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA15046.1 - 5e-06 27.3 0.1 1.1e-05 26.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA15046.1 - 2e-05 23.7 0.0 0.00018 20.6 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin KTI12 PF08433.5 ESA15046.1 - 5.2e-05 22.5 0.0 0.00015 21.0 0.0 1.7 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_14 PF13173.1 ESA15046.1 - 0.00014 21.7 0.1 0.00024 21.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.15 ESA15046.1 - 0.00048 19.8 0.0 0.011 15.4 0.0 2.1 2 0 0 2 2 2 1 Adenylylsulphate kinase ATP_bind_1 PF03029.12 ESA15046.1 - 0.00071 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 ESA15046.1 - 0.00092 19.2 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Cytidylate_kin PF02224.13 ESA15046.1 - 0.0051 16.2 0.3 0.0084 15.5 0.0 1.6 2 0 0 2 2 2 1 Cytidylate kinase SRP54 PF00448.17 ESA15046.1 - 0.0051 16.2 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain T2SE PF00437.15 ESA15046.1 - 0.0052 15.7 0.0 0.009 14.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein CoaE PF01121.15 ESA15046.1 - 0.0055 16.1 0.1 0.12 11.7 0.0 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase G-alpha PF00503.15 ESA15046.1 - 0.0068 15.1 0.2 0.0084 14.8 0.2 1.4 1 1 0 1 1 1 1 G-protein alpha subunit AAA_30 PF13604.1 ESA15046.1 - 0.01 15.4 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESA15046.1 - 0.017 15.0 0.1 0.18 11.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 ESA15046.1 - 0.027 14.2 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain AAA_28 PF13521.1 ESA15046.1 - 0.03 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.12 ESA15046.1 - 0.033 13.5 0.8 0.32 10.3 0.0 2.3 2 1 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.1 ESA15046.1 - 0.033 14.3 0.0 0.054 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain CobU PF02283.11 ESA15046.1 - 0.043 13.2 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase NTPase_1 PF03266.10 ESA15046.1 - 0.046 13.4 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 NTPase TrwB_AAD_bind PF10412.4 ESA15046.1 - 0.051 12.2 0.0 0.072 11.6 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain 6PF2K PF01591.13 ESA15046.1 - 0.054 12.5 0.0 0.11 11.4 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase KAP_NTPase PF07693.9 ESA15046.1 - 0.055 12.4 0.0 0.056 12.4 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_31 PF13614.1 ESA15046.1 - 0.081 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 ESA15046.1 - 0.093 12.3 0.0 0.2 11.3 0.0 1.5 2 0 0 2 2 1 0 NACHT domain UPF0079 PF02367.12 ESA15046.1 - 0.097 12.2 0.0 0.27 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 R3H PF01424.17 ESA15047.1 - 1.7e-15 56.4 0.0 3.5e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 ESA15047.1 - 1.6e-05 24.7 39.8 0.00043 20.1 5.6 13.2 13 2 1 14 14 14 7 NF-X1 type zinc finger Sel1 PF08238.7 ESA15048.1 - 3.1e-32 110.2 6.0 1.5e-07 31.8 0.1 5.2 5 0 0 5 5 5 5 Sel1 repeat DUF3139 PF11337.3 ESA15048.1 - 0.018 15.2 3.1 0.11 12.8 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3139) MIT PF04212.13 ESA15048.1 - 0.021 14.7 3.8 5.4 6.9 1.7 4.0 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA15048.1 - 0.53 9.9 3.3 0.96 9.1 0.7 2.7 2 1 2 4 4 4 0 TPR repeat PHO4 PF01384.15 ESA15049.1 - 1.4e-111 372.3 13.0 2.2e-111 371.6 9.0 1.3 1 1 0 1 1 1 1 Phosphate transporter family Na_H_Exchanger PF00999.16 ESA15050.1 - 2.3e-55 187.6 32.2 3.1e-55 187.2 22.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family ATPase_gene1 PF09527.5 ESA15050.1 - 0.024 14.4 1.2 0.024 14.4 0.8 3.6 4 0 0 4 4 4 0 Putative F0F1-ATPase subunit (ATPase_gene1) Nha1_C PF08619.5 ESA15050.1 - 0.05 12.8 0.1 0.067 12.4 0.1 1.1 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus PSI_PsaF PF02507.10 ESA15050.1 - 2.9 7.4 5.2 26 4.3 0.7 3.1 3 0 0 3 3 3 0 Photosystem I reaction centre subunit III FAD_binding_6 PF00970.19 ESA15051.1 - 2.5e-14 53.1 0.1 7.2e-14 51.7 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 ESA15051.1 - 4.8e-09 35.9 0.0 9.7e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 ESA15051.1 - 3.7e-08 33.9 0.0 1.5e-05 25.5 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA15051.1 - 7.3e-05 22.7 0.6 0.00044 20.1 0.4 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain GATase_2 PF00310.16 ESA15051.1 - 0.12 11.1 0.0 0.21 10.2 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferases class-II GST_N_3 PF13417.1 ESA15052.1 - 2.5e-08 33.9 0.0 5.4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA15052.1 - 2.2e-07 30.9 0.0 7.9e-07 29.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA15052.1 - 1.3e-06 28.2 0.1 2.7e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 ESA15052.1 - 0.0014 18.4 0.0 0.0034 17.2 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 ESA15052.1 - 0.0028 17.6 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESA15052.1 - 0.0079 16.6 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ecl1 PF12855.2 ESA15053.1 - 0.02 14.1 1.3 0.031 13.5 0.9 1.4 1 0 0 1 1 1 0 Life-span regulatory factor WD40 PF00400.27 ESA15054.1 - 0.057 13.3 0.0 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 WD domain, G-beta repeat Tim17 PF02466.14 ESA15057.1 - 2.2e-10 40.6 0.1 4e-10 39.8 0.1 1.4 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_OmpA PF13436.1 ESA15057.1 - 0.00094 18.8 0.0 0.0075 15.9 0.0 2.0 2 0 0 2 2 2 1 Glycine-zipper containing OmpA-like membrane domain Romo1 PF10247.4 ESA15057.1 - 0.21 11.8 2.7 1.4 9.1 0.3 2.7 2 1 1 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 PAPA-1 PF04795.7 ESA15058.1 - 3.1e-18 66.2 0.6 3.1e-18 66.2 0.4 3.6 3 1 0 3 3 3 1 PAPA-1-like conserved region DivIVA PF05103.8 ESA15059.1 - 0.0033 17.4 0.3 0.0042 17.1 0.2 1.3 1 0 0 1 1 1 1 DivIVA protein SurA_N_2 PF13623.1 ESA15059.1 - 0.016 15.1 0.1 0.019 14.9 0.1 1.3 1 0 0 1 1 1 0 SurA N-terminal domain Myosin_tail_1 PF01576.14 ESA15059.1 - 0.019 12.7 1.0 0.021 12.5 0.7 1.1 1 0 0 1 1 1 0 Myosin tail TMF_TATA_bd PF12325.3 ESA15059.1 - 0.019 14.6 5.6 0.089 12.5 4.2 1.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding MpPF1 PF07668.6 ESA15059.1 - 0.048 12.8 0.1 0.059 12.5 0.1 1.0 1 0 0 1 1 1 0 M penetrans paralogue family 1 ISG65-75 PF11727.3 ESA15059.1 - 0.086 11.8 0.2 0.1 11.6 0.1 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Tropomyosin PF00261.15 ESA15059.1 - 0.14 11.2 4.1 0.17 10.9 2.8 1.2 1 0 0 1 1 1 0 Tropomyosin Bac_GDH PF05088.7 ESA15059.1 - 0.21 8.9 3.5 0.23 8.7 2.4 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Reo_sigmaC PF04582.7 ESA15059.1 - 0.41 9.7 3.3 0.47 9.5 2.3 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein CENP-Q PF13094.1 ESA15060.1 - 0.0046 16.9 10.4 0.0046 16.9 7.2 2.5 1 1 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Allexi_40kDa PF05549.6 ESA15060.1 - 0.0071 15.6 1.3 0.0071 15.6 0.9 2.1 1 1 2 3 3 3 1 Allexivirus 40kDa protein DUF932 PF06067.6 ESA15060.1 - 0.038 13.3 1.2 0.062 12.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF932) Laminin_II PF06009.7 ESA15060.1 - 0.046 13.4 1.0 0.046 13.4 0.7 3.0 2 1 1 3 3 3 0 Laminin Domain II DUF3391 PF11871.3 ESA15060.1 - 0.075 13.2 4.3 0.45 10.7 3.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) PV-1 PF06637.6 ESA15060.1 - 0.14 10.7 9.5 0.18 10.3 6.6 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF3166 PF11365.3 ESA15060.1 - 0.27 11.7 15.1 0.1 13.0 1.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3166) AAA_23 PF13476.1 ESA15060.1 - 0.38 11.0 16.5 0.63 10.3 11.4 1.3 1 0 0 1 1 1 0 AAA domain IncA PF04156.9 ESA15060.1 - 0.91 9.0 20.0 0.42 10.1 8.2 2.4 1 1 1 2 2 2 0 IncA protein AAA_14 PF13173.1 ESA15060.1 - 1.5 8.7 5.9 0.71 9.7 1.9 2.0 1 1 1 2 2 2 0 AAA domain Atg14 PF10186.4 ESA15060.1 - 1.6 7.6 12.6 3.3 6.5 8.7 1.5 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4613 PF15390.1 ESA15060.1 - 2.1 6.4 12.2 3.3 5.7 8.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4613) APG6 PF04111.7 ESA15060.1 - 6.7 5.6 25.5 0.3 10.0 11.9 2.5 2 1 1 3 3 3 0 Autophagy protein Apg6 Ham1p_like PF01725.11 ESA15062.1 - 5.9e-55 185.5 0.0 6.7e-55 185.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family MCM PF00493.18 ESA15063.1 - 1.6e-14 53.4 0.1 2.1e-14 53.0 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family DUF3156 PF11354.3 ESA15063.1 - 0.017 14.5 0.1 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3156) SecA_SW PF07516.8 ESA15064.1 - 0.45 10.2 7.3 0.21 11.3 3.2 1.8 2 0 0 2 2 2 0 SecA Wing and Scaffold domain Med16 PF11635.3 ESA15065.1 - 0.06 11.3 0.1 0.061 11.2 0.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 16 Tom22 PF04281.8 ESA15066.1 - 3.4e-25 88.1 0.4 5.3e-25 87.5 0.2 1.3 1 1 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Ig_J_chain PF15097.1 ESA15066.1 - 0.14 11.7 0.2 0.2 11.2 0.1 1.2 1 0 0 1 1 1 0 Immunoglobulin J chain TFIIB PF00382.14 ESA15067.1 - 6e-37 125.2 0.8 2.6e-17 62.3 0.1 2.8 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 ESA15067.1 - 2.6e-24 85.2 2.2 2.6e-24 85.2 1.5 2.0 2 1 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 ESA15067.1 - 1.4e-09 37.1 1.3 3.2e-09 35.9 0.9 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 ESA15067.1 - 2.5e-07 30.2 0.2 0.0013 18.3 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain zf-ribbon_3 PF13248.1 ESA15067.1 - 8.2e-05 21.6 2.4 0.00017 20.6 1.7 1.6 1 0 0 1 1 1 1 zinc-ribbon domain A2L_zn_ribbon PF08792.5 ESA15067.1 - 0.00026 20.3 0.6 0.00055 19.3 0.4 1.6 1 0 0 1 1 1 1 A2L zinc ribbon domain DZR PF12773.2 ESA15067.1 - 0.024 14.4 0.8 0.06 13.1 0.5 1.6 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESA15067.1 - 0.069 12.6 2.7 2.5 7.6 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS91 PF14319.1 ESA15067.1 - 0.1 12.0 0.4 0.24 10.9 0.3 1.6 1 0 0 1 1 1 0 Transposase zinc-binding domain OrfB_Zn_ribbon PF07282.6 ESA15067.1 - 0.17 11.5 1.1 0.37 10.4 0.8 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain RRN7 PF11781.3 ESA15067.1 - 0.68 9.4 5.6 0.19 11.2 1.2 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 DUF383 PF04063.9 ESA15068.1 - 3.3e-71 238.7 3.3 1.1e-70 237.1 0.1 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.8 ESA15068.1 - 7.3e-21 73.5 0.4 2.3e-20 71.9 0.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF384) HEAT_2 PF13646.1 ESA15068.1 - 0.0061 16.8 0.0 0.45 10.8 0.0 3.4 2 2 1 3 3 3 1 HEAT repeats HEAT_EZ PF13513.1 ESA15068.1 - 0.016 15.7 0.1 41 4.8 0.0 3.9 5 0 0 5 5 5 0 HEAT-like repeat HEAT PF02985.17 ESA15068.1 - 0.053 13.6 0.0 0.47 10.6 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat Cyclin_N PF00134.18 ESA15069.1 - 1.5e-09 37.4 0.1 1.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain FISNA PF14484.1 ESA15070.1 - 0.52 10.3 2.8 0.29 11.1 0.3 1.8 2 0 0 2 2 2 0 Fish-specific NACHT associated domain VEFS-Box PF09733.4 ESA15072.1 - 1.1e-20 73.6 0.8 1.1e-20 73.6 0.5 1.6 2 0 0 2 2 2 1 VEFS-Box of polycomb protein Tubulin_C PF03953.12 ESA15072.1 - 0.015 15.2 0.1 0.032 14.2 0.1 1.4 1 0 0 1 1 1 0 Tubulin C-terminal domain zf-Di19 PF05605.7 ESA15072.1 - 0.12 12.5 0.5 0.27 11.3 0.3 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 ESA15072.1 - 0.13 12.6 2.5 0.34 11.3 1.7 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type FSA_C PF10479.4 ESA15073.1 - 0.01 13.9 0.1 0.012 13.7 0.1 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FXR1P_C PF12235.3 ESA15073.1 - 0.03 14.4 3.2 0.032 14.3 2.2 1.1 1 0 0 1 1 1 0 Fragile X-related 1 protein C terminal API5 PF05918.6 ESA15073.1 - 0.62 8.5 3.6 0.63 8.4 2.5 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) RAM PF15320.1 ESA15073.1 - 3.8 7.8 6.4 4.9 7.5 4.4 1.2 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein DUF4233 PF14017.1 ESA15075.1 - 0.018 14.9 1.3 0.02 14.7 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4233) DUF1443 PF07280.6 ESA15075.1 - 0.35 10.4 8.0 0.5 9.9 5.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1443) Pkinase PF00069.20 ESA15077.1 - 8.4e-07 28.3 0.1 9.1e-07 28.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15077.1 - 0.0016 17.5 0.0 0.0018 17.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase p450 PF00067.17 ESA15078.1 - 1.1e-12 47.2 0.0 1.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Phosphorylase PF00343.15 ESA15079.1 - 1.4e-175 585.2 0.3 1.8e-175 584.7 0.2 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Ribosomal_S14 PF00253.16 ESA15080.1 - 6.1e-18 63.9 0.9 9.9e-18 63.2 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e BACK PF07707.10 ESA15081.1 - 1.4e-05 24.8 0.2 0.00013 21.7 0.1 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch Ribosomal_60s PF00428.14 ESA15081.1 - 0.00091 19.5 0.8 0.0014 18.9 0.6 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein Kelch_1 PF01344.20 ESA15085.1 - 4.1e-07 29.4 2.3 0.00012 21.4 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 ESA15085.1 - 1.1e-06 28.5 0.5 0.0017 18.4 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA15085.1 - 3.5e-06 26.5 0.3 0.03 14.0 0.0 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_5 PF13854.1 ESA15085.1 - 4e-06 26.6 4.3 0.0069 16.3 0.0 2.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESA15085.1 - 6e-05 22.7 0.2 0.089 12.5 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA15085.1 - 0.00018 21.5 0.1 0.028 14.5 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA15087.1 - 5.3e-21 73.8 9.7 0.00019 21.4 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.20 ESA15087.1 - 2.4e-19 68.6 13.2 0.0003 20.2 0.1 5.7 5 1 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ESA15087.1 - 9e-18 63.2 1.2 0.004 16.8 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA15087.1 - 6.4e-17 61.0 5.5 0.0071 16.0 0.0 5.6 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA15087.1 - 3e-15 55.9 1.7 0.036 14.2 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA15087.1 - 3e-15 55.7 13.6 3.1e-05 23.7 0.2 5.5 5 0 0 5 5 5 5 Kelch motif SPRY PF00622.23 ESA15088.1 - 2.7e-07 30.7 0.2 4.4e-07 30.0 0.1 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA15088.1 - 0.00013 21.9 0.6 0.00026 20.9 0.4 1.5 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA15088.1 - 0.0084 16.1 0.9 0.92 9.6 0.0 3.3 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain Pkinase PF00069.20 ESA15089.1 - 2.1e-77 259.7 0.0 2.4e-77 259.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15089.1 - 4.9e-37 127.4 0.0 7.4e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA15089.1 - 0.0015 17.5 0.5 0.13 11.2 0.1 2.4 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 ESA15089.1 - 0.011 15.4 0.0 0.042 13.5 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA15089.1 - 0.014 14.2 0.0 0.026 13.3 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.9 ESA15089.1 - 0.044 12.8 0.6 0.12 11.4 0.3 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LSM PF01423.17 ESA15090.1 - 1.9e-17 62.5 0.8 2.6e-17 62.1 0.5 1.2 1 0 0 1 1 1 1 LSM domain P-II PF00543.17 ESA15090.1 - 0.06 13.8 0.0 0.067 13.6 0.0 1.1 1 0 0 1 1 1 0 Nitrogen regulatory protein P-II Mito_carr PF00153.22 ESA15091.1 - 1.8e-65 216.6 0.4 9.2e-21 73.3 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein GAGA PF09237.6 ESA15091.1 - 0.03 13.9 0.1 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 GAGA factor BTB PF00651.26 ESA15092.1 - 1.8e-15 56.8 0.1 3.8e-15 55.8 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15092.1 - 1.2e-05 25.1 0.3 0.00013 21.7 0.2 2.4 1 1 0 1 1 1 1 BTB And C-terminal Kelch RNase_H PF00075.19 ESA15094.1 - 5.5e-05 23.5 0.0 0.13 12.5 0.0 2.4 2 0 0 2 2 2 2 RNase H Nsp1_C PF05064.8 ESA15095.1 - 0.026 14.1 2.4 0.046 13.3 1.6 1.5 1 1 0 1 1 1 0 Nsp1-like C-terminal region F-box-like PF12937.2 ESA15096.1 - 0.0027 17.3 0.9 0.0027 17.3 0.6 3.1 5 0 0 5 5 5 1 F-box-like NADH_oxidored PF08040.6 ESA15096.1 - 0.0043 16.6 0.0 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 MNLL subunit CAMSAP_CH PF11971.3 ESA15097.1 - 0.098 12.3 0.2 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 CAMSAP CH domain MreB_Mbl PF06723.8 ESA15098.1 - 0.018 13.6 0.0 0.066 11.7 0.0 1.9 1 1 0 1 1 1 0 MreB/Mbl protein Mnd1 PF03962.10 ESA15098.1 - 0.023 14.3 9.0 0.052 13.2 6.2 1.5 1 0 0 1 1 1 0 Mnd1 family DUF755 PF05501.6 ESA15098.1 - 0.082 12.9 3.9 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) APG6 PF04111.7 ESA15098.1 - 0.98 8.4 12.8 1.9 7.4 8.9 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Laminin_II PF06009.7 ESA15098.1 - 1.1 8.9 8.9 2.3 7.9 6.2 1.4 1 0 0 1 1 1 0 Laminin Domain II Fib_alpha PF08702.5 ESA15098.1 - 3.1 7.9 8.6 9.5 6.3 5.9 1.8 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family IncA PF04156.9 ESA15098.1 - 8.3 5.9 11.5 15 5.1 8.0 1.4 1 0 0 1 1 1 0 IncA protein p450 PF00067.17 ESA15099.1 - 1.5e-47 162.1 0.4 6.4e-41 140.3 0.0 2.1 1 1 0 2 2 2 2 Cytochrome P450 p450 PF00067.17 ESA15100.1 - 8.3e-32 110.3 0.1 1e-31 110.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 HlyIII PF03006.15 ESA15102.1 - 4.4e-65 219.1 31.5 5.4e-65 218.9 21.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related ADH_zinc_N PF00107.21 ESA15103.1 - 3e-15 55.9 0.0 5.5e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA15103.1 - 2.1e-09 37.0 0.2 5.2e-09 35.8 0.1 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 ESA15103.1 - 8.8e-05 23.4 0.0 0.00016 22.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PHP_C PF13263.1 ESA15103.1 - 0.13 11.7 0.3 0.35 10.4 0.2 1.7 1 0 0 1 1 1 0 PHP-associated Glycos_transf_1 PF00534.15 ESA15103.1 - 0.48 9.8 4.7 5.9 6.2 0.0 3.0 3 0 0 3 3 3 0 Glycosyl transferases group 1 DUF778 PF05608.7 ESA15104.1 - 0.33 10.8 1.9 0.31 10.9 0.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF778) DNA_ligase_OB_2 PF14743.1 ESA15105.1 - 8.7e-24 82.9 0.0 1.9e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.16 ESA15105.1 - 4.7e-18 65.2 0.1 3.3e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 ATP dependent DNA ligase domain BRCT PF00533.21 ESA15105.1 - 2.9e-06 27.3 0.4 9.6e-06 25.6 0.3 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESA15105.1 - 7.6e-06 25.6 0.1 2.2e-05 24.2 0.1 1.8 1 0 0 1 1 1 1 twin BRCT domain WGR PF05406.10 ESA15105.1 - 0.0053 16.6 1.4 0.0053 16.6 0.9 2.0 2 0 0 2 2 2 1 WGR domain Cag12 PF13117.1 ESA15107.1 - 0.0067 16.3 0.2 0.0082 16.0 0.1 1.2 1 0 0 1 1 1 1 Cag pathogenicity island protein Cag12 DUF2704 PF10866.3 ESA15107.1 - 0.038 13.3 2.3 0.048 13.0 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2704) zf-C2H2_4 PF13894.1 ESA15109.1 - 0.00073 19.6 2.8 0.0047 17.1 2.0 2.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-FCS PF06467.9 ESA15109.1 - 0.023 14.3 1.5 0.023 14.3 1.1 2.1 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_6 PF13912.1 ESA15109.1 - 0.027 14.3 2.6 0.038 13.9 0.8 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger PAP_RNA-bind PF04926.10 ESA15109.1 - 0.029 13.9 0.1 0.084 12.3 0.1 1.6 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain Pox_vIL-18BP PF05566.7 ESA15109.1 - 0.071 13.1 0.2 0.22 11.5 0.1 1.8 2 0 0 2 2 2 0 Orthopoxvirus interleukin 18 binding protein zf-C2H2 PF00096.21 ESA15109.1 - 0.25 11.7 6.7 0.15 12.5 2.5 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type DASH_Dad4 PF08650.5 ESA15110.1 - 0.00025 20.8 4.0 0.027 14.3 0.1 2.5 1 1 1 2 2 2 2 DASH complex subunit Dad4 Med9 PF07544.8 ESA15110.1 - 0.0075 15.9 0.3 0.015 14.9 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Nup54 PF13874.1 ESA15110.1 - 0.055 13.1 2.6 0.084 12.5 1.8 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF1759 PF03564.10 ESA15110.1 - 0.83 9.4 5.6 0.25 11.1 1.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) BTB PF00651.26 ESA15112.1 - 1.6e-08 34.4 0.1 3.8e-08 33.3 0.1 1.5 1 1 1 2 2 2 1 BTB/POZ domain Imm6 PF14434.1 ESA15112.1 - 0.024 14.3 0.2 0.042 13.5 0.1 1.4 1 0 0 1 1 1 0 Immunity protein Imm6 APH PF01636.18 ESA15114.1 - 3.3e-06 27.0 0.0 4.2e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family PAG PF15347.1 ESA15115.1 - 0.037 13.1 0.1 0.04 13.0 0.0 1.0 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched DUF4160 PF13711.1 ESA15115.1 - 0.051 13.4 0.6 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) BTB PF00651.26 ESA15116.1 - 2.2e-13 50.1 1.3 1.1e-12 47.8 0.0 2.4 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA15116.1 - 2.8e-07 30.3 0.9 1.1e-06 28.3 0.2 2.5 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA15116.1 - 0.013 14.6 0.1 0.018 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Cupin_4 PF08007.7 ESA15116.1 - 0.052 12.7 0.0 0.067 12.4 0.0 1.1 1 0 0 1 1 1 0 Cupin superfamily protein PIP49_N PF14875.1 ESA15117.1 - 0.71 9.5 4.1 0.19 11.3 0.3 1.7 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 Abhydrolase_6 PF12697.2 ESA15118.1 - 1.5e-27 96.9 0.0 1.8e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA15118.1 - 2.2e-13 50.3 0.0 1.1e-11 44.8 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA15118.1 - 1.4e-10 41.1 0.0 3.7e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 ESA15118.1 - 3e-05 23.5 0.0 6.7e-05 22.4 0.0 1.8 2 1 0 2 2 2 1 Serine hydrolase (FSH1) LCAT PF02450.10 ESA15118.1 - 9.9e-05 21.4 0.0 0.00026 20.0 0.0 1.7 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF2305 PF10230.4 ESA15118.1 - 0.0016 17.8 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) VirJ PF06057.6 ESA15118.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Sel1 PF08238.7 ESA15119.1 - 4.4e-16 58.9 5.6 0.00024 21.6 0.0 6.4 6 0 0 6 6 6 3 Sel1 repeat TPR_1 PF00515.23 ESA15119.1 - 0.001 18.5 13.1 0.1 12.2 0.2 4.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA15119.1 - 0.0029 17.9 1.4 0.033 14.5 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA15119.1 - 0.0033 17.0 7.9 0.053 13.1 0.2 3.6 3 1 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 ESA15119.1 - 0.0051 16.6 11.4 0.1 12.5 0.2 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA15119.1 - 0.0089 16.5 0.4 1.5 9.6 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA15119.1 - 0.021 14.5 10.9 0.16 11.8 0.5 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15119.1 - 0.047 13.6 2.3 2.4 8.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PB1 PF00564.19 ESA15120.1 - 2.2e-10 40.0 0.1 3.1e-10 39.5 0.1 1.3 1 0 0 1 1 1 1 PB1 domain LRR_4 PF12799.2 ESA15121.1 - 0.00061 19.3 3.8 0.00061 19.3 2.6 4.6 3 2 2 5 5 5 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA15121.1 - 0.0068 16.1 8.2 0.013 15.2 2.9 3.4 2 1 1 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 ESA15121.1 - 4.9 7.5 13.5 6.6 7.1 0.3 5.6 6 1 0 6 6 6 0 Leucine Rich Repeat VID27 PF08553.5 ESA15122.1 - 9.6e-245 814.5 14.1 1.2e-244 814.2 9.7 1.1 1 0 0 1 1 1 1 VID27 cytoplasmic protein CRC_subunit PF08624.5 ESA15123.1 - 8.2e-43 145.6 0.1 1.2e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Requiem_N PF14051.1 ESA15123.1 - 0.0026 17.6 0.2 0.007 16.2 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of DPF2/REQ. DUF4414 PF14377.1 ESA15123.1 - 0.067 13.1 0.1 0.18 11.7 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4414) UDPGP PF01704.13 ESA15124.1 - 1.3e-183 610.3 1.7 1.5e-183 610.1 1.2 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Nol1_Nop2_Fmu PF01189.12 ESA15125.1 - 3e-32 112.1 0.0 4.1e-28 98.5 0.0 3.0 2 1 0 2 2 2 2 NOL1/NOP2/sun family GTP_EFTU PF00009.22 ESA15126.1 - 1.1e-59 201.0 0.8 4.7e-59 198.9 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 ESA15126.1 - 2e-38 130.6 0.0 9.3e-38 128.4 0.0 2.2 3 0 0 3 3 3 1 Elongation factor G, domain IV EFG_II PF14492.1 ESA15126.1 - 3.8e-29 100.3 0.0 8.5e-29 99.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 ESA15126.1 - 9.1e-24 83.1 0.0 2e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 ESA15126.1 - 7.5e-14 51.5 0.2 2.4e-13 50.0 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF4196 PF13846.1 ESA15126.1 - 0.2 11.9 1.5 0.5 10.6 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4196) Pkinase_Tyr PF07714.12 ESA15128.1 - 6.5e-25 87.6 0.0 2.1e-20 72.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA15128.1 - 3.6e-23 82.0 0.0 3.2e-18 65.8 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pox_MCEL PF03291.11 ESA15128.1 - 0.0094 14.8 0.2 0.017 14.0 0.1 1.4 1 0 0 1 1 1 1 mRNA capping enzyme DUF4095 PF13338.1 ESA15130.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4095) Pkinase_Tyr PF07714.12 ESA15131.1 - 8.8e-42 142.9 0.0 1.1e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15131.1 - 5.9e-35 120.6 0.0 1.3e-34 119.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15132.1 - 7.7e-07 28.4 0.0 1.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15132.1 - 0.0049 16.0 0.0 0.0085 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15133.1 - 6.1e-26 91.0 1.1 1.1e-23 83.6 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15133.1 - 3.9e-20 72.0 4.6 1.8e-18 66.6 0.1 3.0 2 1 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA15133.1 - 1.2e-11 44.7 12.9 9.4e-06 26.0 0.3 3.9 3 1 0 3 3 3 2 Sel1 repeat TPR_19 PF14559.1 ESA15133.1 - 0.011 16.0 4.2 0.083 13.2 0.2 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat Glyco_transf_49 PF13896.1 ESA15134.1 - 1.9e-11 43.6 3.2 2.3e-11 43.3 2.2 1.1 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_transf_18 PF15024.1 ESA15134.1 - 0.016 13.5 0.0 0.02 13.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 18 DUF148 PF02520.12 ESA15135.1 - 0.1 12.3 0.2 0.28 10.9 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function DUF148 Pkinase_Tyr PF07714.12 ESA15136.1 - 4.3e-40 137.4 0.0 5.8e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15136.1 - 3.7e-38 131.1 0.0 5.3e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA15136.1 - 0.0088 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family A2L_zn_ribbon PF08792.5 ESA15137.1 - 0.0078 15.6 4.1 0.011 15.1 2.9 1.2 1 0 0 1 1 1 1 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.7 ESA15137.1 - 0.011 14.9 1.4 0.02 14.2 1.0 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Ribosomal_S27e PF01667.12 ESA15137.1 - 0.035 13.6 0.4 0.052 13.1 0.3 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 NCD3G PF07562.9 ESA15137.1 - 0.12 12.1 2.0 0.16 11.7 1.4 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Endonuclease_7 PF02945.10 ESA15137.1 - 0.12 12.0 0.9 0.15 11.7 0.6 1.4 1 1 0 1 1 1 0 Recombination endonuclease VII Zn_clus PF00172.13 ESA15137.1 - 0.18 11.7 4.1 0.28 11.1 2.8 1.2 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HTH_Tnp_Tc3_2 PF01498.13 ESA15138.1 - 5.1e-06 26.4 0.9 0.039 14.0 0.7 2.1 1 1 0 1 1 1 1 Transposase HTH_32 PF13565.1 ESA15138.1 - 0.058 14.1 0.3 0.1 13.3 0.1 1.5 1 1 1 2 2 2 0 Homeodomain-like domain zf-UBR PF02207.15 ESA15139.1 - 0.0065 16.1 0.6 0.0066 16.1 0.4 1.1 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Ral PF11058.3 ESA15139.1 - 0.014 14.7 0.2 0.017 14.4 0.1 1.1 1 0 0 1 1 1 0 Antirestriction protein Ral Peptidase_C65 PF10275.4 ESA15140.1 - 5.6e-53 179.7 6.0 6.3e-53 179.6 4.1 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.14 ESA15140.1 - 4.8e-05 23.9 0.0 0.0071 16.9 0.0 2.2 1 1 0 1 1 1 1 OTU-like cysteine protease ThylakoidFormat PF11264.3 ESA15141.1 - 0.024 14.2 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Thylakoid formation protein Ta0938 PF11494.3 ESA15143.1 - 0.2 11.7 1.3 0.61 10.2 0.7 1.8 1 1 1 2 2 2 0 Ta0938 DDE_1 PF03184.14 ESA15144.1 - 2.8e-54 183.5 0.3 3.1e-54 183.4 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA15144.1 - 0.00046 19.9 0.0 0.0007 19.3 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF1192 PF06698.6 ESA15145.1 - 0.001 18.7 1.6 0.73 9.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1192) Striatin PF08232.7 ESA15145.1 - 0.0033 17.7 7.5 0.12 12.7 5.2 2.1 1 1 1 2 2 2 1 Striatin family Tnp_P_element PF12017.3 ESA15145.1 - 0.0047 16.1 3.7 0.34 10.0 0.1 2.1 2 0 0 2 2 2 2 Transposase protein Filament PF00038.16 ESA15145.1 - 0.01 15.3 8.6 0.023 14.1 5.9 1.5 1 1 0 1 1 1 0 Intermediate filament protein DUF848 PF05852.6 ESA15145.1 - 0.012 15.4 3.9 0.012 15.4 1.9 1.6 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DASH_Spc34 PF08657.5 ESA15145.1 - 0.012 15.3 6.6 0.33 10.5 0.8 2.2 1 1 0 2 2 2 0 DASH complex subunit Spc34 SlyX PF04102.7 ESA15145.1 - 0.015 15.6 4.3 0.35 11.2 1.1 2.3 2 0 0 2 2 2 0 SlyX CASP_C PF08172.7 ESA15145.1 - 0.057 12.4 2.5 0.077 12.0 1.8 1.2 1 0 0 1 1 1 0 CASP C terminal DUF4201 PF13870.1 ESA15145.1 - 0.088 12.2 12.6 0.12 11.8 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Lzipper-MIP1 PF14389.1 ESA15145.1 - 0.099 12.7 1.7 0.54 10.3 0.6 2.1 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Sec34 PF04136.10 ESA15145.1 - 0.22 11.2 4.4 0.22 11.2 2.2 1.6 1 1 0 1 1 1 0 Sec34-like family DUF4404 PF14357.1 ESA15145.1 - 0.24 11.8 2.6 0.4 11.1 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) TMF_TATA_bd PF12325.3 ESA15145.1 - 0.4 10.4 6.3 2.3 7.9 4.3 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4094 PF13334.1 ESA15145.1 - 0.43 11.0 2.6 9.1 6.7 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) LemA PF04011.7 ESA15145.1 - 0.45 9.5 7.8 3.2 6.8 0.2 2.9 2 1 0 3 3 3 0 LemA family Med4 PF10018.4 ESA15145.1 - 0.53 9.6 5.7 0.6 9.4 1.7 2.0 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Tropomyosin_1 PF12718.2 ESA15145.1 - 0.69 9.7 10.2 0.36 10.6 3.5 2.1 1 1 1 2 2 2 0 Tropomyosin like Syntaxin-6_N PF09177.6 ESA15145.1 - 0.77 10.1 5.6 2 8.8 2.2 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.4 ESA15145.1 - 0.9 9.7 12.3 0.52 10.4 0.7 2.4 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cep57_CLD_2 PF14197.1 ESA15145.1 - 0.98 9.4 6.8 2.5 8.1 2.0 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF2304 PF10066.4 ESA15145.1 - 1.2 8.9 3.5 5.9 6.7 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) TPR_MLP1_2 PF07926.7 ESA15145.1 - 2.2 8.0 12.2 4.5 7.0 8.5 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Med9 PF07544.8 ESA15145.1 - 2.4 7.9 6.2 6.7 6.5 0.5 2.8 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_1 PF00170.16 ESA15145.1 - 2.5 8.1 10.6 1.6 8.7 1.1 2.8 2 1 0 2 2 2 0 bZIP transcription factor PRKCSH-like PF12999.2 ESA15145.1 - 2.5 7.6 7.0 1 8.8 2.1 1.9 1 1 1 2 2 2 0 Glucosidase II beta subunit-like DivIC PF04977.10 ESA15145.1 - 3.2 7.3 10.2 3.9 7.0 1.4 2.6 2 1 0 2 2 2 0 Septum formation initiator TSC22 PF01166.13 ESA15145.1 - 3.3 7.7 8.7 11 6.1 0.1 3.1 2 1 1 3 3 3 0 TSC-22/dip/bun family CENP-F_leu_zip PF10473.4 ESA15145.1 - 4.1 7.2 9.8 12 5.7 0.4 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.5 ESA15145.1 - 5 7.2 10.2 42 4.2 7.1 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Syntaxin PF00804.20 ESA15145.1 - 5.6 7.1 9.3 11 6.2 1.1 2.2 1 1 1 2 2 2 0 Syntaxin DUF3886 PF13025.1 ESA15145.1 - 6.2 6.8 8.0 1.9 8.4 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) FlaC_arch PF05377.6 ESA15145.1 - 8 6.4 8.6 16 5.5 0.6 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) F-box-like PF12937.2 ESA15147.1 - 0.00098 18.8 0.0 0.0036 16.9 0.0 2.0 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 ESA15147.1 - 0.15 12.1 3.9 0.23 11.6 0.2 3.4 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.1 ESA15147.1 - 2.5 7.9 12.6 0.2 11.4 1.0 4.0 3 2 1 4 4 4 0 Leucine rich repeat CENP-B_N PF04218.8 ESA15148.1 - 4.6e-07 29.1 0.4 7.4e-07 28.4 0.3 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain TrbM PF07424.6 ESA15148.1 - 0.0027 17.6 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 TrbM UPF0122 PF04297.9 ESA15148.1 - 0.053 13.5 0.2 0.074 13.0 0.1 1.4 1 1 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_Tnp_4 PF13613.1 ESA15148.1 - 0.08 12.4 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Mur_ligase_C PF02875.16 ESA15148.1 - 0.12 12.4 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain CLCA_N PF08434.6 ESA15149.1 - 0.038 13.2 0.1 0.052 12.7 0.0 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel HeLo PF14479.1 ESA15150.1 - 0.00033 20.4 3.0 0.00059 19.6 2.1 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation CMV_1a PF12467.3 ESA15150.1 - 0.019 15.3 1.8 0.038 14.3 1.2 1.5 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family TPR_MLP1_2 PF07926.7 ESA15150.1 - 0.019 14.7 10.8 2.5 7.8 6.3 2.8 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 ESA15150.1 - 0.14 11.8 12.9 0.021 14.4 4.9 2.3 1 1 0 2 2 2 0 Mnd1 family DUF1664 PF07889.7 ESA15150.1 - 0.77 9.5 10.2 0.072 12.8 2.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Mem_trans PF03547.13 ESA15150.1 - 0.91 7.7 3.1 1.1 7.4 2.2 1.2 1 0 0 1 1 1 0 Membrane transport protein COG2 PF06148.6 ESA15150.1 - 2.1 8.2 7.2 0.38 10.6 1.0 2.6 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Atg14 PF10186.4 ESA15150.1 - 2.4 7.0 13.7 3.8 6.3 9.5 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Snapin_Pallidin PF14712.1 ESA15150.1 - 5 7.5 11.7 2.6 8.4 2.0 3.8 3 2 1 4 4 4 0 Snapin/Pallidin Vfa1 PF08432.5 ESA15150.1 - 5.3 7.0 12.8 2.2 8.2 7.1 1.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF4284 PF14112.1 ESA15151.1 - 0.059 13.8 4.5 0.4 11.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4284) ApoO PF09769.4 ESA15151.1 - 0.27 10.9 1.7 0.33 10.6 0.3 1.7 2 0 0 2 2 2 0 Apolipoprotein O DUF1778 PF08681.6 ESA15152.1 - 0.0021 17.8 0.1 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) DUF2262 PF10020.4 ESA15152.1 - 0.015 15.4 0.3 0.017 15.3 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) DUF4041 PF13250.1 ESA15152.1 - 0.05 13.1 0.6 0.083 12.4 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4041) Exonuc_VII_S PF02609.11 ESA15152.1 - 0.17 11.6 0.7 0.4 10.4 0.2 1.9 1 1 1 2 2 2 0 Exonuclease VII small subunit CHU_C PF13585.1 ESA15153.1 - 0.084 12.7 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 C-terminal domain of CHU protein family Ricin_B_lectin PF00652.17 ESA15155.1 - 0.00011 22.2 0.0 0.00021 21.3 0.0 1.5 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 ESA15155.1 - 0.00032 21.0 0.1 0.0024 18.2 0.0 1.9 1 1 1 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Ribosomal_L6e PF01159.14 ESA15157.1 - 0.056 13.6 3.3 1 9.6 0.3 2.6 2 1 0 2 2 2 0 Ribosomal protein L6e Sel1 PF08238.7 ESA15158.1 - 4.7e-82 268.6 25.9 2.7e-14 53.2 0.8 8.2 8 0 0 8 8 8 8 Sel1 repeat TPR_11 PF13414.1 ESA15158.1 - 2.9e-12 46.0 31.0 0.00083 18.9 0.8 6.1 3 2 5 8 8 8 7 TPR repeat TPR_6 PF13174.1 ESA15158.1 - 2.7e-07 30.5 3.5 4 8.1 0.1 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15158.1 - 5.1e-07 30.1 0.0 5 7.9 0.0 5.0 2 1 2 5 5 5 2 Tetratricopeptide repeat MIT PF04212.13 ESA15158.1 - 6.6e-06 25.9 17.2 4.1 7.3 0.1 8.3 9 0 0 9 9 9 1 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 ESA15158.1 - 0.00068 19.2 0.8 20 5.3 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15158.1 - 0.02 14.8 18.1 5.6 6.9 0.3 7.1 3 2 3 6 6 6 0 Tetratricopeptide repeat Peptidase_S39 PF02122.10 ESA15158.1 - 0.058 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase S39 PPR PF01535.15 ESA15158.1 - 0.12 12.4 1.0 81 3.5 0.0 4.7 5 0 0 5 5 5 0 PPR repeat TPR_17 PF13431.1 ESA15158.1 - 0.43 10.9 16.5 24 5.4 0.1 6.5 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA15158.1 - 1.9 8.6 40.4 18 5.5 0.0 11.7 14 0 0 14 14 14 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA15159.1 - 2.9e-104 339.2 44.4 8.2e-12 45.3 0.2 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_11 PF13414.1 ESA15159.1 - 8.5e-13 47.7 49.6 0.0047 16.5 2.4 8.2 2 2 7 9 9 9 9 TPR repeat TPR_16 PF13432.1 ESA15159.1 - 2.1e-09 37.7 0.0 13 6.5 0.0 6.8 3 2 5 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA15159.1 - 5.5e-09 35.9 9.4 24 5.6 0.0 9.5 10 0 0 10 10 10 0 Tetratricopeptide repeat MIT PF04212.13 ESA15159.1 - 5.3e-06 26.2 23.5 6.1 6.8 0.0 9.4 10 0 0 10 10 10 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA15159.1 - 5e-05 23.1 25.1 4.2 7.3 0.2 9.4 2 2 7 9 9 9 2 Tetratricopeptide repeat PPR PF01535.15 ESA15159.1 - 6.4e-05 22.6 10.2 14 5.9 0.0 7.9 9 0 0 9 9 9 1 PPR repeat HATPase_c PF02518.21 ESA15159.1 - 0.052 13.2 0.0 31 4.3 0.0 3.8 1 1 2 3 3 3 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 23S_rRNA_IVP PF05635.6 ESA15159.1 - 0.072 12.9 0.6 4.7 7.1 0.0 3.4 3 1 1 4 4 4 0 23S rRNA-intervening sequence protein TPR_1 PF00515.23 ESA15159.1 - 7.1 6.4 78.8 5.1 6.8 0.3 17.1 20 0 0 20 20 20 0 Tetratricopeptide repeat Remorin_C PF03763.8 ESA15160.1 - 0.035 13.6 0.7 0.055 12.9 0.5 1.2 1 0 0 1 1 1 0 Remorin, C-terminal region Sel1 PF08238.7 ESA15162.1 - 1.8e-86 282.6 49.9 2.4e-12 47.0 0.4 8.0 8 0 0 8 8 8 8 Sel1 repeat MIT PF04212.13 ESA15162.1 - 3.7e-05 23.5 16.4 4.5 7.2 0.0 7.7 8 0 0 8 8 8 2 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA15162.1 - 0.00024 20.9 17.5 4.5 7.2 0.0 6.8 3 2 3 6 6 6 5 Tetratricopeptide repeat CPW_WPC PF09717.5 ESA15162.1 - 4.8 7.8 8.5 21 5.8 0.6 3.0 1 1 1 2 2 2 0 Plasmodium falciparum domain of unknown function (CPW_WPC) BTB PF00651.26 ESA15163.1 - 3.3e-17 62.4 0.1 1.2e-16 60.6 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15163.1 - 6.5e-12 45.6 3.2 1.8e-10 40.9 0.6 3.3 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA15163.1 - 3.6e-05 23.5 0.4 0.00016 21.4 0.2 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch Sel1 PF08238.7 ESA15164.1 - 2.7e-109 355.2 29.4 3.6e-11 43.3 0.8 12.1 12 0 0 12 12 12 12 Sel1 repeat Myb_DNA-bind_3 PF12776.2 ESA15165.1 - 0.011 16.3 0.1 0.011 16.3 0.1 2.6 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain eIF-5_eIF-2B PF01873.12 ESA15165.1 - 0.025 14.2 1.5 0.091 12.4 0.4 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Dimer_Tnp_hAT PF05699.9 ESA15167.1 - 4.5e-09 35.8 0.1 5.3e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region GerE PF00196.14 ESA15167.1 - 0.091 12.0 0.2 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family DUF19 PF01579.13 ESA15168.1 - 5.8 6.8 13.0 0.2 11.6 2.9 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF19) Ion_trans PF00520.26 ESA15169.1 - 0.15 11.3 1.8 0.2 10.8 1.3 1.3 1 0 0 1 1 1 0 Ion transport protein Fe_bilin_red PF05996.7 ESA15171.1 - 0.011 15.2 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase zf-CCHC_2 PF13696.1 ESA15171.1 - 0.035 13.6 0.8 0.066 12.7 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.18 ESA15171.1 - 0.092 12.7 2.5 0.14 12.1 1.8 1.3 1 0 0 1 1 1 0 Zinc knuckle PhoU PF01895.14 ESA15171.1 - 0.11 12.8 0.4 0.23 11.9 0.3 1.5 1 0 0 1 1 1 0 PhoU domain ubiquitin PF00240.18 ESA15172.1 - 1.8e-50 168.2 8.6 8.6e-30 101.9 0.4 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA15172.1 - 6.8e-31 105.7 8.9 1.2e-17 63.2 0.5 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA15172.1 - 5.5e-07 29.7 5.5 5e-05 23.4 0.2 3.3 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA15172.1 - 8.6e-06 25.6 1.5 0.0032 17.3 0.2 2.6 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Telomere_Sde2 PF13019.1 ESA15172.1 - 2.3e-05 24.1 0.2 0.019 14.6 0.0 2.1 2 0 0 2 2 2 2 Telomere stability and silencing DUF2407 PF10302.4 ESA15172.1 - 5.3e-05 23.3 0.5 0.00053 20.1 0.3 2.1 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain ATLF PF07737.6 ESA15172.1 - 0.0013 18.1 1.5 0.0017 17.8 1.0 1.1 1 0 0 1 1 1 1 Anthrax toxin lethal factor, N- and C-terminal domain Cystatin PF00031.16 ESA15172.1 - 0.0093 16.0 1.0 0.096 12.8 0.1 2.3 1 1 1 2 2 2 1 Cystatin domain Plexin_cytopl PF08337.7 ESA15172.1 - 0.026 12.8 9.3 0.79 7.9 0.3 3.4 1 1 2 4 4 4 0 Plexin cytoplasmic RasGAP domain EMG1 PF03587.9 ESA15172.1 - 0.029 13.6 0.2 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 EMG1/NEP1 methyltransferase TUG-UBL1 PF11470.3 ESA15172.1 - 0.048 13.5 0.8 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 GLUT4 regulating protein TUG UBX PF00789.15 ESA15172.1 - 0.13 12.3 0.3 0.55 10.3 0.0 2.1 3 0 0 3 3 3 0 UBX domain PI3K_rbd PF00794.13 ESA15172.1 - 0.18 11.7 5.3 2.5 8.0 0.4 2.5 1 1 1 2 2 2 0 PI3-kinase family, ras-binding domain ecTbetaR2 PF08917.5 ESA15174.1 - 0.074 12.8 0.2 0.14 11.9 0.2 1.4 1 1 0 1 1 1 0 Transforming growth factor beta receptor 2 ectodomain Chitin_synth_2 PF03142.10 ESA15175.1 - 3e-51 174.4 0.3 5e-51 173.6 0.0 1.5 2 0 0 2 2 2 1 Chitin synthase Cyt-b5 PF00173.23 ESA15175.1 - 0.016 15.0 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain Dimer_Tnp_hAT PF05699.9 ESA15176.1 - 2e-16 59.3 0.1 2.2e-16 59.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region SRP14 PF02290.10 ESA15178.1 - 1.1e-22 79.7 3.3 2.2e-22 78.7 2.3 1.5 1 0 0 1 1 1 1 Signal recognition particle 14kD protein Y_phosphatase2 PF03162.8 ESA15178.1 - 0.0013 18.1 1.2 0.0019 17.6 0.2 1.6 1 1 1 2 2 2 1 Tyrosine phosphatase family HAND PF09110.6 ESA15178.1 - 0.077 13.4 10.4 0.064 13.6 3.7 2.0 2 0 0 2 2 2 0 HAND DUF3323 PF11796.3 ESA15178.1 - 0.11 11.7 0.9 0.14 11.4 0.4 1.2 1 1 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) DUF365 PF04033.7 ESA15178.1 - 3.2 7.8 7.3 0.41 10.6 0.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF365) MCM_bind PF09739.4 ESA15179.1 - 6.6e-27 93.4 2.1 9e-27 93.0 0.4 1.9 2 0 0 2 2 2 1 Mini-chromosome maintenance replisome factor Racemase_4 PF13615.1 ESA15179.1 - 3.6e-21 75.3 2.0 4.6e-21 74.9 0.5 1.9 2 0 0 2 2 2 1 Putative alanine racemase F-box-like PF12937.2 ESA15181.1 - 0.008 15.8 0.1 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA15181.1 - 0.01 15.4 0.1 0.059 13.0 0.0 2.3 2 0 0 2 2 2 0 F-box domain F-box PF00646.28 ESA15182.1 - 0.00092 18.8 0.0 0.0052 16.4 0.0 2.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA15182.1 - 0.0036 17.0 0.2 0.0036 17.0 0.1 2.0 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 ESA15182.1 - 0.31 10.8 3.4 6.1 6.6 0.2 3.4 2 1 1 3 3 3 0 Leucine rich repeat Dimer_Tnp_hAT PF05699.9 ESA15183.1 - 2.2e-09 36.7 0.3 7.2e-09 35.1 0.0 2.0 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Adaptin_binding PF10199.4 ESA15183.1 - 0.0068 16.6 0.0 0.012 15.8 0.0 1.4 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 NB PF04159.8 ESA15183.1 - 0.13 12.0 0.0 0.37 10.5 0.0 1.7 1 0 0 1 1 1 0 NB glycoprotein RNA_pol_A_bac PF01000.21 ESA15184.1 - 2.2e-30 105.0 0.3 6e-30 103.6 0.0 1.8 2 1 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 ESA15184.1 - 1.2e-16 59.5 0.0 1.8e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Ubie_methyltran PF01209.13 ESA15186.1 - 1.1e-82 276.6 0.0 1.4e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 ESA15186.1 - 2.1e-16 59.8 0.0 3.7e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA15186.1 - 1.1e-14 54.6 0.0 2.1e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA15186.1 - 2.1e-14 53.7 0.0 4.3e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA15186.1 - 7.2e-11 42.3 0.0 1.5e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA15186.1 - 9.7e-10 38.3 0.0 1.5e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA15186.1 - 1e-09 38.9 0.0 1.9e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA15186.1 - 2.3e-08 34.0 0.0 5.6e-08 32.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.12 ESA15186.1 - 0.009 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 ESA15186.1 - 0.021 14.1 0.0 0.058 12.7 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.13 ESA15186.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase MBOAT_2 PF13813.1 ESA15189.1 - 2.5e-11 43.4 4.2 4.4e-11 42.6 2.5 1.8 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Pkinase PF00069.20 ESA15191.1 - 2.3e-11 43.3 1.1 9.5e-11 41.3 0.7 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15191.1 - 4.2e-11 42.4 0.0 3.1e-08 33.0 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Crust_neurohorm PF01147.12 ESA15191.1 - 0.065 12.5 1.6 0.13 11.5 1.1 1.4 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Pkinase_Tyr PF07714.12 ESA15192.1 - 0.027 13.5 0.0 1.6 7.7 0.0 2.7 3 0 0 3 3 3 0 Protein tyrosine kinase Glyco_hydro_11 PF00457.12 ESA15192.1 - 0.027 13.7 6.4 0.035 13.4 0.4 3.0 1 1 2 3 3 3 0 Glycosyl hydrolases family 11 Pkinase PF00069.20 ESA15192.1 - 0.063 12.4 1.6 3.8 6.5 0.0 2.8 3 0 0 3 3 3 0 Protein kinase domain Phage-A118_gp45 PF10653.4 ESA15192.1 - 0.086 12.7 0.1 9.4 6.1 0.1 2.5 2 0 0 2 2 2 0 Protein gp45 of Bacteriophage A118 AAA_18 PF13238.1 ESA15192.1 - 3 8.1 5.1 2.8 8.2 0.5 2.6 2 2 0 2 2 2 0 AAA domain Pkinase PF00069.20 ESA15197.1 - 4.3e-27 94.8 0.1 2.9e-25 88.8 0.1 3.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15197.1 - 3.2e-23 82.1 0.0 2.7e-17 62.6 0.0 2.7 1 1 1 2 2 2 2 Protein tyrosine kinase ComFB PF10719.4 ESA15197.1 - 0.084 12.6 0.8 1.5 8.5 0.0 2.9 2 0 0 2 2 2 0 Late competence development protein ComFB Membr_traf_MHD PF10540.4 ESA15199.1 - 0.13 12.0 1.7 0.89 9.3 0.5 2.2 1 1 1 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain zf-H2C2_2 PF13465.1 ESA15201.1 - 7.2e-11 41.8 12.8 5.1e-06 26.5 0.2 3.9 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 ESA15201.1 - 1.5e-10 40.7 14.5 6.9e-06 26.0 1.9 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA15201.1 - 1.3e-07 31.4 8.2 0.0011 19.1 1.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.7 ESA15201.1 - 0.00024 21.1 0.5 0.0005 20.1 0.4 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 ESA15201.1 - 0.0045 17.0 1.6 0.049 13.7 0.2 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 ESA15201.1 - 0.0065 16.2 2.4 1.1 9.0 0.1 2.6 2 0 0 2 2 2 2 BED zinc finger zf-C2HC_2 PF13913.1 ESA15201.1 - 0.015 14.9 0.5 0.015 14.9 0.3 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type TerY-C PF15616.1 ESA15201.1 - 0.053 13.4 3.6 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 TerY-C metal binding domain zf-C2H2_6 PF13912.1 ESA15201.1 - 0.063 13.2 4.4 1.2 9.1 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.2 ESA15201.1 - 0.063 13.5 2.8 0.41 10.9 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ETF PF01012.16 ESA15202.1 - 3.1e-43 147.3 0.6 4e-43 146.9 0.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain RNA_POL_M_15KD PF02150.11 ESA15203.1 - 9.5e-10 38.0 8.2 7.5e-09 35.1 2.3 2.8 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 ESA15203.1 - 2e-09 36.9 12.0 5.6e-09 35.4 1.1 2.9 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) UPF0547 PF10571.4 ESA15203.1 - 0.014 15.0 0.4 0.014 15.0 0.3 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DZR PF12773.2 ESA15203.1 - 0.19 11.5 6.9 3.3 7.5 0.1 2.6 2 0 0 2 2 2 0 Double zinc ribbon Ogr_Delta PF04606.7 ESA15203.1 - 0.39 10.3 14.3 0.09 12.4 3.3 3.2 2 2 0 2 2 2 0 Ogr/Delta-like zinc finger Lar_restr_allev PF14354.1 ESA15203.1 - 0.53 10.6 7.0 0.18 12.1 0.6 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 ESA15203.1 - 0.98 8.7 9.9 0.91 8.8 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Tme5_EGF_like PF09064.5 ESA15203.1 - 2.4 7.8 6.1 12 5.6 1.4 2.6 2 0 0 2 2 2 0 Thrombomodulin like fifth domain, EGF-like DUF4407 PF14362.1 ESA15206.1 - 0.14 11.1 4.5 0.2 10.5 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Imm22 PF15592.1 ESA15208.1 - 0.035 14.4 0.8 0.39 11.0 0.6 2.1 1 1 0 1 1 1 0 Immunity protein 22 DUF4375 PF14300.1 ESA15208.1 - 0.052 13.5 3.4 0.052 13.5 1.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) HSBP1 PF06825.7 ESA15208.1 - 0.22 11.0 1.4 2 8.0 1.0 2.6 1 1 0 1 1 1 0 Heat shock factor binding protein 1 Astro_capsid PF03115.9 ESA15209.1 - 0.16 10.1 8.9 0.19 9.9 6.2 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor BUD22 PF09073.5 ESA15209.1 - 0.28 10.1 14.9 0.36 9.8 10.3 1.1 1 0 0 1 1 1 0 BUD22 ESAG1 PF03238.8 ESA15211.1 - 0.065 12.5 0.0 0.18 11.1 0.0 1.6 1 1 1 2 2 2 0 ESAG protein Peptidase_C50 PF03568.12 ESA15211.1 - 0.1 11.2 0.1 0.092 11.4 0.1 1.1 1 0 0 1 1 1 0 Peptidase family C50 Vac_ImportDeg PF09783.4 ESA15213.1 - 1.2e-31 109.6 1.2 1.3e-31 109.4 0.0 1.5 2 0 0 2 2 2 1 Vacuolar import and degradation protein Rota_NS26 PF01525.11 ESA15215.1 - 0.12 12.1 0.2 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Rotavirus NS26 APH PF01636.18 ESA15217.1 - 1.8e-22 80.2 0.0 3.7e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA15217.1 - 9.3e-05 22.0 0.7 0.00018 21.1 0.3 1.7 1 1 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.9 ESA15217.1 - 0.00023 20.2 0.0 0.17 10.8 0.0 2.2 2 0 0 2 2 2 2 Fructosamine kinase RIO1 PF01163.17 ESA15217.1 - 0.0038 16.5 1.2 0.15 11.3 0.1 2.5 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 ESA15217.1 - 0.021 13.9 0.4 2.3 7.3 0.1 2.3 2 0 0 2 2 2 0 Protein kinase domain HSBP1 PF06825.7 ESA15217.1 - 0.19 11.3 5.6 0.52 9.9 0.9 2.8 2 1 0 2 2 2 0 Heat shock factor binding protein 1 Astacin PF01400.19 ESA15218.1 - 0.011 15.1 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) ATG19_autophagy PF12744.2 ESA15218.1 - 0.054 12.7 0.1 0.064 12.5 0.0 1.0 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding Enolase_N PF03952.11 ESA15221.1 - 0.1 12.5 0.3 0.16 11.8 0.2 1.4 1 1 0 1 1 1 0 Enolase, N-terminal domain Pkinase_Tyr PF07714.12 ESA15222.1 - 0.0006 18.9 0.0 0.00093 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MENTAL PF10457.4 ESA15223.1 - 0.032 13.8 0.3 0.032 13.8 0.2 1.9 1 1 1 2 2 2 0 Cholesterol-capturing domain NPCC PF08058.6 ESA15223.1 - 0.1 12.4 1.3 0.14 11.9 0.9 1.2 1 0 0 1 1 1 0 Nuclear pore complex component stn_TNFRSF12A PF12191.3 ESA15226.1 - 0.0028 17.7 0.5 0.0048 16.9 0.3 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Pkinase PF00069.20 ESA15227.1 - 4.6e-13 48.9 0.0 5.1e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15227.1 - 7.6e-06 25.1 0.0 8.6e-06 24.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15231.1 - 1e-17 64.1 0.3 1.6e-17 63.5 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15231.1 - 2.1e-13 49.9 0.0 3.7e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TRM13 PF05206.9 ESA15232.1 - 3.4e-80 269.0 1.4 4.4e-80 268.6 1.0 1.1 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.3 ESA15232.1 - 3.5e-10 39.0 2.3 3.5e-10 39.0 1.6 2.7 3 0 0 3 3 3 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.7 ESA15232.1 - 4.6e-08 32.5 0.5 4.6e-08 32.5 0.3 2.3 3 0 0 3 3 3 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.1 ESA15232.1 - 0.0018 18.0 0.5 0.004 16.8 0.3 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA15232.1 - 0.029 13.9 0.4 0.06 12.9 0.1 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF2457 PF10446.4 ESA15232.1 - 0.64 8.6 4.5 1.1 7.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoplasmin PF03066.10 ESA15232.1 - 2.2 7.7 6.8 2.3 7.7 3.8 1.6 2 0 0 2 2 2 0 Nucleoplasmin CDC73 PF05179.9 ESA15233.1 - 1.3e-43 149.3 9.1 2.3e-43 148.5 6.3 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family Ribonucleas_3_3 PF14622.1 ESA15234.1 - 8.7e-33 113.0 0.0 1.6e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 ESA15234.1 - 3.1e-19 69.4 2.7 3.6e-19 69.2 0.0 2.4 2 2 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.20 ESA15234.1 - 7.2e-13 48.9 2.2 1.4e-12 47.9 0.0 2.5 3 0 0 3 3 3 1 Double-stranded RNA binding motif Phage_integ_N PF09003.5 ESA15234.1 - 0.091 12.4 0.5 1.8 8.3 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage lambda integrase, N-terminal domain COX7a PF02238.10 ESA15234.1 - 0.16 11.7 0.7 0.33 10.7 0.5 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIa Pkinase_Tyr PF07714.12 ESA15235.1 - 6.4e-06 25.4 0.0 6.9e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15235.1 - 4.3e-05 22.7 0.0 4.6e-05 22.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain BEN PF10523.4 ESA15239.1 - 0.11 12.5 1.0 0.32 11.0 0.7 1.8 1 0 0 1 1 1 0 BEN domain HEAT_2 PF13646.1 ESA15240.1 - 1.7e-09 37.8 0.4 1.5e-05 25.2 0.0 4.9 5 0 0 5 5 5 1 HEAT repeats HEAT PF02985.17 ESA15240.1 - 3.3e-08 32.9 1.1 0.028 14.4 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat CLASP_N PF12348.3 ESA15240.1 - 0.0028 17.0 0.1 0.85 8.9 0.0 2.8 2 1 1 3 3 3 2 CLASP N terminal DUF1878 PF08963.5 ESA15240.1 - 0.01 16.0 0.5 0.04 14.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) HEAT_EZ PF13513.1 ESA15240.1 - 0.02 15.3 0.2 8.6 6.9 0.0 3.5 3 0 0 3 3 3 0 HEAT-like repeat RTTN_N PF14726.1 ESA15240.1 - 0.52 10.9 3.5 41 4.8 0.0 3.5 3 0 0 3 3 3 0 Rotatin, an armadillo repeat protein, centriole functioning Ribosomal_S8 PF00410.14 ESA15241.1 - 9.7e-29 99.8 0.1 1.3e-28 99.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 PHD_2 PF13831.1 ESA15244.1 - 1.3e-11 43.5 4.0 1.3e-11 43.5 2.8 2.2 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H_2 PF13832.1 ESA15244.1 - 5.7e-11 42.3 1.7 8.8e-08 32.1 0.0 2.2 2 0 0 2 2 2 2 PHD-zinc-finger like domain PHD PF00628.24 ESA15244.1 - 1.1e-08 34.6 9.3 1.1e-08 34.6 6.4 2.3 3 0 0 3 3 3 1 PHD-finger zf-HC5HC2H PF13771.1 ESA15244.1 - 0.0019 18.2 4.0 5.1 7.3 0.0 3.2 3 0 0 3 3 3 2 PHD-like zinc-binding domain C1_1 PF00130.17 ESA15244.1 - 0.023 14.4 2.7 0.023 14.4 1.9 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.6 ESA15244.1 - 0.19 11.7 5.8 0.23 11.4 1.8 2.3 2 0 0 2 2 2 0 RING-like domain COX17 PF05051.8 ESA15244.1 - 0.23 11.4 5.3 0.54 10.3 3.7 1.6 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) DUF948 PF06103.6 ESA15245.1 - 0.00011 21.9 2.3 0.0037 17.1 0.3 2.2 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) Spc7 PF08317.6 ESA15245.1 - 0.00014 20.6 1.4 0.00019 20.1 1.0 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Not3 PF04065.10 ESA15245.1 - 0.00015 21.0 0.9 0.00016 21.0 0.1 1.4 2 0 0 2 2 1 1 Not1 N-terminal domain, CCR4-Not complex component Laminin_II PF06009.7 ESA15245.1 - 0.00017 21.3 1.6 0.00027 20.7 0.8 1.5 1 1 0 1 1 1 1 Laminin Domain II DUF1192 PF06698.6 ESA15245.1 - 0.00037 20.2 0.2 0.017 14.9 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) ADIP PF11559.3 ESA15245.1 - 0.00037 20.4 1.5 0.00075 19.4 0.2 1.8 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Prominin PF05478.6 ESA15245.1 - 0.0005 17.7 0.9 0.00066 17.3 0.6 1.1 1 0 0 1 1 1 1 Prominin DivIC PF04977.10 ESA15245.1 - 0.00057 19.3 2.8 0.0047 16.3 0.2 2.2 2 0 0 2 2 2 1 Septum formation initiator TSC22 PF01166.13 ESA15245.1 - 0.00062 19.6 3.8 0.0043 16.9 0.8 2.4 2 0 0 2 2 2 1 TSC-22/dip/bun family AAA_27 PF13514.1 ESA15245.1 - 0.0018 16.0 0.1 0.0022 15.7 0.1 1.0 1 0 0 1 1 1 1 AAA domain Baculo_PEP_C PF04513.7 ESA15245.1 - 0.0021 17.8 2.7 0.0035 17.1 1.9 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.3 ESA15245.1 - 0.0023 17.6 5.2 0.014 15.1 1.8 2.4 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding PspA_IM30 PF04012.7 ESA15245.1 - 0.0026 17.1 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 PspA/IM30 family Med9 PF07544.8 ESA15245.1 - 0.0029 17.2 1.7 0.0046 16.6 0.3 1.8 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF342 PF03961.8 ESA15245.1 - 0.0031 16.0 1.3 0.0032 15.9 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) Laminin_I PF06008.9 ESA15245.1 - 0.0032 16.8 2.4 0.0045 16.3 0.8 1.6 1 1 0 1 1 1 1 Laminin Domain I IFT57 PF10498.4 ESA15245.1 - 0.0065 15.2 1.8 0.0086 14.8 1.3 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 AAA_13 PF13166.1 ESA15245.1 - 0.007 14.9 1.3 0.0085 14.6 0.9 1.1 1 0 0 1 1 1 1 AAA domain DUF3373 PF11853.3 ESA15245.1 - 0.0073 14.8 0.5 0.011 14.3 0.1 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF3373) HSBP1 PF06825.7 ESA15245.1 - 0.0075 15.8 5.1 0.017 14.6 1.1 2.6 2 1 0 2 2 2 1 Heat shock factor binding protein 1 DASH_Spc34 PF08657.5 ESA15245.1 - 0.0084 15.7 0.6 0.01 15.5 0.4 1.1 1 0 0 1 1 1 1 DASH complex subunit Spc34 Prefoldin_2 PF01920.15 ESA15245.1 - 0.0091 15.7 3.0 0.032 13.9 0.6 2.2 2 0 0 2 2 2 1 Prefoldin subunit DUF4559 PF15112.1 ESA15245.1 - 0.0093 15.1 5.0 0.014 14.6 3.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4559) Reo_sigmaC PF04582.7 ESA15245.1 - 0.0094 15.1 0.1 0.012 14.8 0.1 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Snf7 PF03357.16 ESA15245.1 - 0.0095 15.3 3.5 0.41 10.0 1.0 2.1 1 1 1 2 2 2 1 Snf7 DUF972 PF06156.8 ESA15245.1 - 0.011 16.0 3.6 0.012 15.9 1.2 1.8 1 1 0 2 2 1 0 Protein of unknown function (DUF972) IDO PF01231.13 ESA15245.1 - 0.011 14.1 0.1 0.014 13.8 0.0 1.3 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase ArsR PF09824.4 ESA15245.1 - 0.011 14.9 1.3 0.017 14.4 0.3 1.7 2 1 0 2 2 1 0 ArsR transcriptional regulator Orthopox_A5L PF06193.6 ESA15245.1 - 0.012 15.5 4.8 0.08 12.8 1.0 2.1 1 1 1 2 2 2 0 Orthopoxvirus A5L protein-like Snapin_Pallidin PF14712.1 ESA15245.1 - 0.014 15.7 0.6 0.69 10.2 0.0 2.4 2 0 0 2 2 2 0 Snapin/Pallidin GAS PF13851.1 ESA15245.1 - 0.015 14.5 3.8 0.046 12.9 2.6 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding AKNA PF12443.3 ESA15245.1 - 0.015 15.3 1.1 0.066 13.2 0.2 2.2 1 1 1 2 2 2 0 AT-hook-containing transcription factor UPF0449 PF15136.1 ESA15245.1 - 0.015 15.4 1.6 1.2 9.3 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 COG6 PF06419.6 ESA15245.1 - 0.016 13.3 2.5 0.022 12.9 1.7 1.2 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 BicD PF09730.4 ESA15245.1 - 0.016 13.5 1.3 0.02 13.2 0.9 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D EzrA PF06160.7 ESA15245.1 - 0.019 13.2 0.9 0.023 12.8 0.6 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Syntaxin_2 PF14523.1 ESA15245.1 - 0.019 14.9 4.0 0.021 14.8 0.7 2.0 1 1 1 2 2 2 0 Syntaxin-like protein FH2 PF02181.18 ESA15245.1 - 0.02 13.7 1.0 0.28 10.0 0.5 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain LPP PF04728.8 ESA15245.1 - 0.024 14.4 0.2 0.068 12.9 0.0 1.7 2 0 0 2 2 1 0 Lipoprotein leucine-zipper BLOC1_2 PF10046.4 ESA15245.1 - 0.024 14.7 3.5 0.078 13.1 2.5 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4200 PF13863.1 ESA15245.1 - 0.025 14.5 3.4 0.067 13.1 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF327 PF03885.8 ESA15245.1 - 0.025 14.3 2.4 0.1 12.4 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF327) Fmp27_WPPW PF10359.4 ESA15245.1 - 0.026 12.9 0.2 0.025 12.9 0.2 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain HlyE PF06109.8 ESA15245.1 - 0.027 13.4 0.2 0.035 13.1 0.2 1.1 1 0 0 1 1 1 0 Haemolysin E (HlyE) Tropomyosin PF00261.15 ESA15245.1 - 0.027 13.5 1.1 0.029 13.4 0.2 1.5 2 0 0 2 2 1 0 Tropomyosin DUF904 PF06005.7 ESA15245.1 - 0.027 14.7 6.8 0.84 9.9 3.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Syntaxin PF00804.20 ESA15245.1 - 0.03 14.4 2.2 0.073 13.2 0.3 2.1 1 1 1 2 2 2 0 Syntaxin Sipho_Gp157 PF05565.6 ESA15245.1 - 0.034 13.7 3.2 0.14 11.7 1.5 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 MscS_porin PF12795.2 ESA15245.1 - 0.036 13.3 0.1 0.27 10.5 0.0 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain AF0941-like PF14591.1 ESA15245.1 - 0.039 14.0 2.0 0.075 13.0 1.3 1.6 1 1 0 1 1 1 0 AF0941-like FliJ PF02050.11 ESA15245.1 - 0.039 13.9 0.1 0.098 12.7 0.1 1.7 1 1 0 1 1 1 0 Flagellar FliJ protein Erp_C PF06780.6 ESA15245.1 - 0.04 13.7 4.0 0.057 13.2 2.8 1.3 1 1 0 1 1 1 0 Erp protein C-terminus DUF4455 PF14643.1 ESA15245.1 - 0.042 12.4 0.6 0.051 12.1 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) P4Ha_N PF08336.6 ESA15245.1 - 0.043 13.6 1.7 0.06 13.1 0.4 1.7 2 0 0 2 2 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF1397 PF07165.6 ESA15245.1 - 0.056 12.6 0.8 0.12 11.5 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1397) WD40_alt PF14077.1 ESA15245.1 - 0.057 13.0 1.1 0.17 11.5 0.8 1.9 1 0 0 1 1 1 0 Alternative WD40 repeat motif DUF3573 PF12097.3 ESA15245.1 - 0.06 11.9 0.7 0.074 11.6 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) GP41 PF00517.12 ESA15245.1 - 0.06 12.8 0.1 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 Retroviral envelope protein DUF1664 PF07889.7 ESA15245.1 - 0.062 13.0 3.1 0.089 12.6 0.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.6 ESA15245.1 - 0.063 13.1 8.6 0.12 12.2 1.0 3.1 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin_3 PF13758.1 ESA15245.1 - 0.065 13.0 3.8 0.72 9.6 1.5 2.4 1 1 1 2 2 2 0 Prefoldin subunit Fusion_gly PF00523.13 ESA15245.1 - 0.066 11.2 0.1 0.093 10.7 0.0 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 MCPsignal PF00015.16 ESA15245.1 - 0.067 12.7 0.1 0.089 12.3 0.1 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1319 PF07028.6 ESA15245.1 - 0.068 13.3 3.3 0.12 12.5 0.6 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) PhoU_div PF01865.11 ESA15245.1 - 0.071 12.2 1.3 0.1 11.7 0.8 1.3 1 1 0 1 1 1 0 Protein of unknown function DUF47 MIP-T3 PF10243.4 ESA15245.1 - 0.074 11.5 0.2 0.095 11.1 0.2 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 bZIP_1 PF00170.16 ESA15245.1 - 0.078 12.9 8.0 0.23 11.4 1.9 2.8 2 1 1 3 3 3 0 bZIP transcription factor DNA_primase_lrg PF04104.9 ESA15245.1 - 0.085 12.1 0.2 0.15 11.3 0.0 1.5 2 0 0 2 2 1 0 Eukaryotic and archaeal DNA primase, large subunit Phasin PF05597.6 ESA15245.1 - 0.086 12.6 1.0 0.27 10.9 0.7 1.8 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TBPIP PF07106.8 ESA15245.1 - 0.09 12.3 5.0 0.21 11.1 3.5 1.7 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) zf-C4H2 PF10146.4 ESA15245.1 - 0.096 12.6 1.9 0.17 11.8 1.3 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein GCN5L1 PF06320.8 ESA15245.1 - 0.11 12.3 2.6 0.12 12.2 0.8 1.7 1 1 1 2 2 1 0 GCN5-like protein 1 (GCN5L1) CorA PF01544.13 ESA15245.1 - 0.11 11.5 1.9 0.29 10.1 0.5 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Tropomyosin_1 PF12718.2 ESA15245.1 - 0.12 12.2 3.7 0.11 12.2 0.8 1.9 2 0 0 2 2 2 0 Tropomyosin like DUF4618 PF15397.1 ESA15245.1 - 0.12 11.6 3.8 0.39 9.9 2.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Fib_alpha PF08702.5 ESA15245.1 - 0.12 12.4 3.3 0.52 10.4 2.3 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family UPF0184 PF03670.8 ESA15245.1 - 0.13 12.4 1.1 0.25 11.5 0.8 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) ATG16 PF08614.6 ESA15245.1 - 0.13 12.0 5.1 0.29 10.9 3.6 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HALZ PF02183.13 ESA15245.1 - 0.14 11.9 2.0 1.1 8.9 0.5 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper WXG100 PF06013.7 ESA15245.1 - 0.14 12.1 0.1 1.5 8.9 0.0 2.6 2 1 1 3 3 2 0 Proteins of 100 residues with WXG CENP-F_leu_zip PF10473.4 ESA15245.1 - 0.15 11.8 7.9 0.45 10.3 4.1 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PhoU PF01895.14 ESA15245.1 - 0.16 12.4 1.7 0.2 12.1 0.7 1.6 1 1 0 1 1 1 0 PhoU domain HR1 PF02185.11 ESA15245.1 - 0.16 11.7 5.3 0.42 10.4 2.1 2.7 1 1 1 2 2 1 0 Hr1 repeat LXG PF04740.7 ESA15245.1 - 0.17 11.6 3.0 0.33 10.7 2.1 1.5 1 1 0 1 1 1 0 LXG domain of WXG superfamily NPV_P10 PF05531.7 ESA15245.1 - 0.18 12.1 2.7 3.6 7.9 1.9 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.1 ESA15245.1 - 0.18 11.7 1.3 2 8.4 0.0 2.5 3 0 0 3 3 2 0 FlxA-like protein Syntaxin-6_N PF09177.6 ESA15245.1 - 0.2 12.0 2.7 0.95 9.9 1.9 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal KLRAQ PF10205.4 ESA15245.1 - 0.22 11.5 1.7 0.34 10.9 0.5 1.7 1 1 1 2 2 1 0 Predicted coiled-coil domain-containing protein DUF4446 PF14584.1 ESA15245.1 - 0.23 11.2 1.9 1.1 9.1 0.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) DUF2046 PF09755.4 ESA15245.1 - 0.24 10.2 5.4 0.099 11.5 1.2 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) Seryl_tRNA_N PF02403.17 ESA15245.1 - 0.26 11.3 3.9 0.43 10.6 0.8 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Kinetocho_Slk19 PF12709.2 ESA15245.1 - 0.26 11.3 2.7 0.29 11.2 0.5 2.0 2 0 0 2 2 1 0 Central kinetochore-associated Lge1 PF11488.3 ESA15245.1 - 0.29 11.3 1.6 0.42 10.8 0.9 1.5 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DASH_Duo1 PF08651.5 ESA15245.1 - 0.34 10.5 4.5 0.37 10.3 0.8 2.4 1 1 2 3 3 3 0 DASH complex subunit Duo1 Cast PF10174.4 ESA15245.1 - 0.38 8.7 3.5 0.57 8.1 2.4 1.3 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone IncA PF04156.9 ESA15245.1 - 0.39 10.3 2.3 0.63 9.5 1.6 1.4 1 1 0 1 1 1 0 IncA protein TMF_TATA_bd PF12325.3 ESA15245.1 - 0.46 10.2 5.6 0.9 9.2 3.9 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding K-box PF01486.12 ESA15245.1 - 0.53 10.1 4.3 9.7 6.0 3.0 2.4 1 1 0 1 1 1 0 K-box region Prefoldin PF02996.12 ESA15245.1 - 0.59 9.7 6.0 3.9 7.1 1.6 3.0 2 1 1 3 3 3 0 Prefoldin subunit Vps51 PF08700.6 ESA15245.1 - 0.8 9.5 3.4 2.4 8.0 0.7 2.6 2 1 0 2 2 2 0 Vps51/Vps67 Spc24 PF08286.6 ESA15245.1 - 1.1 9.0 5.8 0.68 9.6 1.1 2.2 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 ORF6C PF10552.4 ESA15245.1 - 1.4 8.6 6.8 0.65 9.7 0.7 2.7 1 1 2 3 3 3 0 ORF6C domain DMPK_coil PF08826.5 ESA15245.1 - 1.7 8.5 4.9 3 7.8 2.0 2.4 2 1 0 2 2 2 0 DMPK coiled coil domain like bZIP_2 PF07716.10 ESA15245.1 - 2.6 7.9 9.2 0.25 11.1 1.0 2.7 3 0 0 3 3 3 0 Basic region leucine zipper FtsH_ext PF06480.10 ESA15246.1 - 0.082 13.0 0.6 3.6 7.8 0.0 2.3 2 1 0 2 2 2 0 FtsH Extracellular SF3a60_bindingd PF12108.3 ESA15246.1 - 0.6 9.6 5.3 14 5.2 0.1 3.2 3 0 0 3 3 3 0 Splicing factor SF3a60 binding domain Pkinase_Tyr PF07714.12 ESA15247.1 - 1.1e-33 116.4 0.0 1.2e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15247.1 - 1.2e-33 116.3 0.0 1.3e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA15248.1 - 0.00046 19.8 0.0 5.2 6.6 0.0 4.1 4 0 0 4 4 4 2 BCS1 N terminal Herpes_Helicase PF02689.9 ESA15249.1 - 4.8e-05 21.3 0.0 4.8e-05 21.3 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA15249.1 - 0.042 13.9 0.1 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain MARVEL PF01284.18 ESA15250.1 - 0.018 14.8 3.9 0.018 14.8 2.7 2.4 2 1 0 2 2 2 0 Membrane-associating domain Oxidored_q3 PF00499.15 ESA15250.1 - 0.33 10.7 10.8 1.5 8.5 7.5 2.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Cytochrom_B_C PF00032.12 ESA15250.1 - 2.5 8.3 10.2 0.96 9.7 0.9 2.5 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD 7TMR-DISM_7TM PF07695.6 ESA15250.1 - 9.1 5.8 24.8 24 4.5 17.2 1.8 1 1 0 1 1 1 0 7TM diverse intracellular signalling POM121 PF15229.1 ESA15251.1 - 0.052 12.9 10.0 0.059 12.7 6.9 1.1 1 0 0 1 1 1 0 POM121 family Pox_Ag35 PF03286.9 ESA15251.1 - 0.16 11.4 11.9 0.18 11.3 8.2 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Striatin PF08232.7 ESA15251.1 - 0.29 11.4 10.0 0.38 11.0 6.9 1.2 1 0 0 1 1 1 0 Striatin family FancD2 PF14631.1 ESA15251.1 - 0.97 6.4 7.4 1 6.3 5.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Miff PF05644.6 ESA15251.1 - 0.97 9.0 5.6 1.2 8.7 3.9 1.0 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DUF913 PF06025.7 ESA15251.1 - 1.3 7.6 5.3 1.4 7.6 3.7 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2201_N PF13203.1 ESA15251.1 - 1.4 8.0 6.2 1.5 7.9 4.3 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF1510 PF07423.6 ESA15251.1 - 1.4 8.2 13.8 1.7 7.9 9.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Zip PF02535.17 ESA15251.1 - 1.5 7.7 3.3 1.6 7.6 2.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.2 ESA15251.1 - 1.9 6.0 10.8 2.2 5.8 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.7 ESA15251.1 - 2.2 8.1 9.7 2.4 7.9 6.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RP-C_C PF11800.3 ESA15251.1 - 2.9 7.5 7.7 3.3 7.3 5.3 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Neur_chan_memb PF02932.11 ESA15251.1 - 3 7.6 7.3 3.5 7.4 5.1 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec62 PF03839.11 ESA15251.1 - 3.7 6.9 13.4 4.2 6.7 9.3 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3807 PF12720.2 ESA15251.1 - 4.9 7.2 12.3 6 6.9 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF1980 PF09323.5 ESA15251.1 - 7.2 6.3 7.9 8.3 6.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Rtf2 PF04641.7 ESA15251.1 - 9.2 5.3 16.8 10 5.1 11.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger BTB PF00651.26 ESA15252.1 - 2e-07 30.9 0.0 2.4e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF570 PF04489.8 ESA15252.1 - 0.11 10.9 0.0 0.11 10.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF570) SecA_SW PF07516.8 ESA15253.1 - 0.025 14.3 0.1 0.027 14.2 0.1 1.1 1 0 0 1 1 1 0 SecA Wing and Scaffold domain BTB PF00651.26 ESA15254.1 - 8.3e-18 64.4 0.3 1.7e-17 63.4 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15254.1 - 2.1e-08 33.9 1.5 2.7e-06 27.1 0.1 3.3 2 1 1 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA15254.1 - 1.4e-06 28.3 4.7 3.4e-06 27.0 3.3 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA15255.1 - 1.4e-17 63.6 0.0 2.9e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15255.1 - 3.4e-07 30.3 2.1 3.4e-07 30.3 1.4 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15255.1 - 3.8e-05 23.4 1.0 0.003 17.3 0.1 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA15255.1 - 0.0014 17.8 0.1 0.0022 17.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.26 ESA15256.1 - 1.9e-17 63.2 0.2 3.6e-17 62.3 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15256.1 - 4.4e-15 55.8 2.1 8.2e-15 55.0 1.4 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15256.1 - 0.00013 21.7 0.0 0.00092 19.0 0.0 2.4 2 1 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15257.1 - 1.8e-19 69.7 0.0 4.4e-19 68.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15257.1 - 5.6e-11 42.5 6.3 1.3e-10 41.3 4.4 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15257.1 - 6e-07 29.2 0.0 1.2e-05 25.0 0.0 2.6 2 1 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15258.1 - 1.6e-19 69.9 1.4 5.9e-19 68.0 0.1 2.2 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15258.1 - 3.4e-10 40.0 1.9 7.5e-10 38.9 1.3 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15258.1 - 4.7e-07 29.6 2.7 1.3e-06 28.1 0.0 2.9 4 0 0 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15259.1 - 1.1e-18 67.2 0.0 6.2e-18 64.8 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15259.1 - 1.8e-12 47.3 4.8 3.7e-12 46.4 3.3 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15259.1 - 2.2e-08 33.8 0.0 1.6e-06 27.8 0.0 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch PIG-F PF06699.6 ESA15260.1 - 6.7e-28 97.9 5.8 7.5e-28 97.7 4.0 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F DUF4310 PF14187.1 ESA15260.1 - 0.019 14.4 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4310) Gly-zipper_YMGG PF13441.1 ESA15260.1 - 1.1 8.8 4.3 1.6 8.2 0.9 2.0 2 0 0 2 2 2 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.10 ESA15260.1 - 1.2 8.8 5.5 2.5 7.8 1.0 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.1 ESA15260.1 - 3.3 7.4 6.1 3.3 7.4 1.1 2.1 2 0 0 2 2 2 0 Glycine zipper DUF2273 PF10031.4 ESA15260.1 - 6 6.5 6.7 12 5.6 0.6 2.4 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) Upf2 PF04050.9 ESA15262.1 - 0.044 13.5 0.3 0.058 13.1 0.2 1.2 1 0 0 1 1 1 0 Up-frameshift suppressor 2 CGI-121 PF08617.5 ESA15262.1 - 0.045 13.4 1.8 0.056 13.1 1.2 1.1 1 0 0 1 1 1 0 Kinase binding protein CGI-121 BTB PF00651.26 ESA15266.1 - 1.5e-16 60.3 0.8 2.7e-16 59.5 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15266.1 - 4.8e-07 29.8 0.2 4.5e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15266.1 - 3.8e-06 26.6 5.6 5.6e-06 26.1 0.5 3.3 3 1 1 4 4 4 1 BTB And C-terminal Kelch Asp_protease_2 PF13650.1 ESA15267.1 - 1.7e-08 34.8 0.2 2.9e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 ESA15267.1 - 9.6e-07 28.3 0.1 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA15267.1 - 7.8e-05 22.4 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 ESA15267.1 - 0.0078 16.1 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 ESA15267.1 - 0.017 15.0 0.2 0.04 13.8 0.2 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease Peptidase_A2B PF12384.3 ESA15267.1 - 0.1 11.9 0.6 0.3 10.4 0.1 1.8 2 0 0 2 2 2 0 Ty3 transposon peptidase PBP1_TM PF14812.1 ESA15267.1 - 0.12 12.6 1.6 3.3 8.0 0.6 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BTB PF00651.26 ESA15268.1 - 1.2e-15 57.4 0.3 7.2e-15 54.9 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15268.1 - 3.3e-11 43.3 3.9 5.8e-11 42.5 2.7 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15268.1 - 1.2e-07 31.4 0.8 1.7e-06 27.8 0.1 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA15269.1 - 0.0012 17.9 0.2 0.0024 16.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase YusW PF14039.1 ESA15269.1 - 0.16 12.2 2.8 0.66 10.2 1.8 2.1 1 1 0 1 1 1 0 YusW-like protein DNA_pol_alpha_N PF12254.3 ESA15269.1 - 0.24 11.2 4.6 0.067 13.0 0.9 1.8 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal Ion_trans PF00520.26 ESA15272.1 - 2.4e-07 30.1 13.9 4.1e-07 29.4 9.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans PF00520.26 ESA15273.1 - 0.0033 16.6 1.3 0.0049 16.1 0.9 1.3 1 0 0 1 1 1 1 Ion transport protein DUF3384 PF11864.3 ESA15275.1 - 0.00033 19.2 4.8 0.00034 19.2 3.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Peptidase_U57 PF05582.7 ESA15275.1 - 0.13 11.1 0.4 0.15 10.9 0.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 Apis_Csd PF11671.3 ESA15275.1 - 2.8 7.7 8.1 3.1 7.6 5.6 1.1 1 0 0 1 1 1 0 Complementary sex determiner protein zf-BED PF02892.10 ESA15276.1 - 6e-08 32.3 6.4 1.4e-07 31.1 4.4 1.6 1 0 0 1 1 1 1 BED zinc finger Dimer_Tnp_hAT PF05699.9 ESA15277.1 - 5e-13 48.4 0.0 5.7e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region XRN_N PF03159.13 ESA15281.1 - 1.5e-63 214.3 0.0 1.7e-63 214.2 0.0 1.0 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus AAA PF00004.24 ESA15283.1 - 1.8e-97 322.6 0.0 7e-49 165.4 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA15283.1 - 3.6e-16 58.9 0.0 2.9e-09 36.3 0.0 2.5 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ESA15283.1 - 1.5e-12 48.4 0.0 8.4e-07 29.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESA15283.1 - 1.6e-12 47.6 0.8 0.0027 17.8 0.0 5.1 3 2 2 5 5 4 2 AAA domain AAA_2 PF07724.9 ESA15283.1 - 2.9e-12 46.8 0.0 5.4e-05 23.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESA15283.1 - 3.8e-12 46.5 2.2 8.2e-05 22.6 0.0 4.3 3 2 1 4 4 3 2 AAA ATPase domain AAA_14 PF13173.1 ESA15283.1 - 4.1e-11 42.8 0.0 0.00026 20.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 ESA15283.1 - 3.6e-10 39.8 0.0 0.00045 20.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 ESA15283.1 - 1e-09 38.0 4.9 0.13 11.6 0.0 4.3 2 2 1 4 4 4 3 AAA domain TIP49 PF06068.8 ESA15283.1 - 1.6e-09 37.0 0.0 4.4e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_5 PF07728.9 ESA15283.1 - 2.3e-09 37.0 2.1 0.0055 16.4 0.1 4.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESA15283.1 - 5.1e-09 35.5 0.0 0.0037 16.3 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin RNA_helicase PF00910.17 ESA15283.1 - 2.2e-08 34.2 0.0 0.0054 16.8 0.0 3.0 2 1 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 ESA15283.1 - 1.4e-07 31.1 2.6 0.0041 16.8 0.1 3.1 3 1 0 3 3 2 2 Part of AAA domain IstB_IS21 PF01695.12 ESA15283.1 - 1.6e-07 30.9 0.7 0.015 14.6 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.1 ESA15283.1 - 2.4e-07 30.8 0.0 0.0077 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 ESA15283.1 - 3.6e-07 29.9 0.3 0.11 12.1 0.0 4.0 4 0 0 4 4 4 2 NACHT domain Mg_chelatase PF01078.16 ESA15283.1 - 5.1e-07 29.0 0.4 0.031 13.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 ESA15283.1 - 6.4e-07 29.7 0.1 0.021 15.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain Cytidylate_kin2 PF13189.1 ESA15283.1 - 2.4e-06 27.5 0.0 0.0041 17.0 0.0 2.5 2 0 0 2 2 2 2 Cytidylate kinase-like family KaiC PF06745.8 ESA15283.1 - 2.6e-06 26.7 0.4 0.86 8.6 0.0 3.5 2 1 1 3 3 3 2 KaiC ABC_tran PF00005.22 ESA15283.1 - 7.4e-06 26.3 0.0 0.12 12.6 0.0 2.9 2 1 0 2 2 2 2 ABC transporter SKI PF01202.17 ESA15283.1 - 1.5e-05 24.9 0.0 0.11 12.3 0.0 2.9 2 0 0 2 2 2 2 Shikimate kinase Arch_ATPase PF01637.13 ESA15283.1 - 2.6e-05 24.0 1.5 1 8.9 0.0 4.5 3 2 1 4 4 4 2 Archaeal ATPase AAA_3 PF07726.6 ESA15283.1 - 4e-05 23.2 0.0 0.094 12.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 ESA15283.1 - 5.2e-05 22.2 0.0 0.17 10.7 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain Sigma54_activat PF00158.21 ESA15283.1 - 5.3e-05 22.7 0.1 0.4 10.1 0.0 3.7 3 1 1 4 4 4 1 Sigma-54 interaction domain Rad17 PF03215.10 ESA15283.1 - 0.00031 19.5 0.0 0.31 9.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein Sigma54_activ_2 PF14532.1 ESA15283.1 - 0.00045 20.2 0.0 0.76 9.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Viral_helicase1 PF01443.13 ESA15283.1 - 0.00084 18.9 0.8 0.93 8.9 0.0 2.7 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 ESA15283.1 - 0.00091 18.5 0.3 1.3 8.2 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein Parvo_NS1 PF01057.12 ESA15283.1 - 0.00095 18.1 0.1 1.2 8.0 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 DUF815 PF05673.8 ESA15283.1 - 0.001 18.0 0.0 0.024 13.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) UPF0079 PF02367.12 ESA15283.1 - 0.0018 17.8 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 ESA15283.1 - 0.0036 17.1 0.2 5 6.9 0.0 3.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.20 ESA15283.1 - 0.0052 16.3 0.0 3 7.2 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 ESA15283.1 - 0.0061 16.2 0.5 8.6 6.0 0.0 3.5 2 1 1 3 3 3 0 NTPase AFG1_ATPase PF03969.11 ESA15283.1 - 0.0062 15.3 0.0 2.9 6.5 0.0 2.3 2 0 0 2 2 2 1 AFG1-like ATPase AAA_11 PF13086.1 ESA15283.1 - 0.01 15.4 0.8 3.8 7.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain DUF2075 PF09848.4 ESA15283.1 - 0.014 14.3 0.0 1.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.1 ESA15283.1 - 0.017 14.7 0.1 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA15283.1 - 0.023 14.2 0.0 7 6.1 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 ESA15283.1 - 0.026 13.4 0.0 0.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ADK PF00406.17 ESA15283.1 - 0.031 14.1 0.0 9 6.1 0.0 2.8 2 0 0 2 2 2 0 Adenylate kinase Bac_DnaA PF00308.13 ESA15283.1 - 0.045 13.3 0.0 5.8 6.4 0.0 2.9 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_10 PF12846.2 ESA15283.1 - 0.075 12.4 1.0 22 4.3 0.0 3.5 3 0 0 3 3 3 0 AAA-like domain CPT PF07931.7 ESA15283.1 - 0.077 12.6 0.0 0.79 9.3 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Vps4_C PF09336.5 ESA15283.1 - 0.084 12.7 0.2 3.5 7.6 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain IPT PF01745.11 ESA15283.1 - 0.17 11.0 0.0 15 4.6 0.0 2.4 2 0 0 2 2 2 0 Isopentenyl transferase DUF1462 PF07315.6 ESA15284.1 - 0.0047 16.8 0.7 0.0057 16.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1462) YqfD PF06898.6 ESA15284.1 - 0.052 12.2 4.9 0.063 11.9 3.4 1.0 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Sel1 PF08238.7 ESA15285.1 - 2.9e-54 180.3 4.5 5.5e-10 39.5 0.0 5.0 5 0 0 5 5 5 5 Sel1 repeat DUF2235 PF09994.4 ESA15285.1 - 0.0018 17.6 3.5 2.9 7.1 0.0 3.2 1 1 1 3 3 3 3 Uncharacterized alpha/beta hydrolase domain (DUF2235) Fib_alpha PF08702.5 ESA15286.1 - 0.012 15.7 5.1 0.012 15.7 3.5 4.2 4 1 2 6 6 6 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.7 ESA15286.1 - 0.14 11.9 3.7 0.82 9.4 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 ESA15286.1 - 6.9 6.2 13.1 3 7.4 5.2 2.6 2 0 0 2 2 2 0 IncA protein Occludin_ELL PF07303.8 ESA15286.1 - 8.2 7.2 10.4 20 5.9 0.2 3.6 3 0 0 3 3 3 0 Occludin homology domain RIO1 PF01163.17 ESA15288.1 - 1.9e-49 167.5 0.3 1.9e-49 167.5 0.2 2.5 3 0 0 3 3 3 1 RIO1 family Rio2_N PF09202.6 ESA15288.1 - 2.5e-34 117.1 1.6 4.3e-34 116.4 0.1 2.2 3 0 0 3 3 3 1 Rio2, N-terminal APH PF01636.18 ESA15288.1 - 2.5e-10 40.4 0.9 0.0001 22.1 0.3 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 ESA15288.1 - 1.6e-06 27.3 0.0 4.9e-05 22.4 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA15288.1 - 0.0048 16.0 1.7 0.0066 15.6 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain MarR_2 PF12802.2 ESA15288.1 - 0.039 13.6 0.0 0.17 11.5 0.0 2.0 2 0 0 2 2 2 0 MarR family PAS_6 PF08348.6 ESA15288.1 - 0.068 12.7 3.8 0.2 11.1 2.6 1.7 1 0 0 1 1 1 0 YheO-like PAS domain Prominin PF05478.6 ESA15289.1 - 0.021 12.3 3.2 0.03 11.8 2.2 1.1 1 0 0 1 1 1 0 Prominin MinC_N PF05209.8 ESA15289.1 - 0.063 13.0 0.2 0.2 11.4 0.1 1.8 1 1 1 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain DUF4071 PF13281.1 ESA15289.1 - 0.16 10.7 3.2 0.061 12.1 0.5 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4071) BDV_P24 PF06595.6 ESA15289.1 - 0.56 9.9 7.9 0.063 13.0 1.2 2.0 2 0 0 2 2 2 0 Borna disease virus P24 protein CENP-T PF15511.1 ESA15289.1 - 3.5 6.7 18.7 0.38 9.9 1.9 2.6 2 1 1 3 3 3 0 Centromere kinetochore component CENP-T BTB PF00651.26 ESA15292.1 - 4.3e-14 52.4 0.1 7.7e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15292.1 - 1.6e-09 37.8 0.5 2.5e-08 34.0 0.0 2.8 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA15292.1 - 1.2e-05 25.0 0.4 0.00038 20.2 0.1 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch BCS1_N PF08740.6 ESA15293.1 - 0.0055 16.3 0.0 2.8 7.5 0.0 2.3 2 0 0 2 2 2 2 BCS1 N terminal DUF4284 PF14112.1 ESA15293.1 - 1.9 8.9 9.4 0.65 10.4 1.6 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4284) Gtr1_RagA PF04670.7 ESA15298.1 - 0.00062 18.9 0.7 0.0017 17.5 0.5 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Glyco_hydro_31 PF01055.21 ESA15299.1 - 8.8e-173 575.1 1.8 4.8e-172 572.7 0.8 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 ESA15299.1 - 6.4e-09 35.5 0.1 8.1e-08 32.0 0.1 2.8 2 0 0 2 2 2 1 Galactose mutarotase-like Trefoil PF00088.13 ESA15299.1 - 0.0011 18.5 1.7 0.0011 18.5 1.2 2.2 2 0 0 2 2 2 1 Trefoil (P-type) domain ArdA PF07275.6 ESA15300.1 - 0.05 13.8 1.4 0.054 13.7 1.0 1.1 1 0 0 1 1 1 0 Antirestriction protein (ArdA) DUF3832 PF12909.2 ESA15300.1 - 0.067 13.2 1.4 0.26 11.3 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3832) Spc7 PF08317.6 ESA15300.1 - 0.095 11.3 1.9 0.1 11.2 1.3 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Pkinase PF00069.20 ESA15301.1 - 2.8e-10 39.7 0.0 3.2e-10 39.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15301.1 - 4.7e-09 35.6 0.0 5.4e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA15301.1 - 0.0028 17.4 0.1 0.0095 15.6 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA15302.1 - 1.1e-36 126.2 0.0 1.5e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15302.1 - 4e-32 111.3 0.0 6.1e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA15303.1 - 6.3e-16 58.2 3.1 8.7e-15 54.5 2.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15303.1 - 1.6e-15 56.8 0.4 1.1e-11 44.3 0.0 3.0 2 1 1 3 3 3 2 Protein tyrosine kinase Crust_neurohorm PF01147.12 ESA15303.1 - 0.1 11.9 2.7 0.23 10.7 1.9 1.5 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Rgp1 PF08737.5 ESA15304.1 - 1e-67 229.0 1.1 1.8e-67 228.2 0.0 1.9 2 0 0 2 2 2 1 Rgp1 SMC_Nse1 PF07574.8 ESA15304.1 - 0.072 12.7 0.2 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex Afi1 PF07792.7 ESA15305.1 - 6.9e-42 142.8 0.0 2.1e-41 141.3 0.0 1.6 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.4 ESA15305.1 - 1.2e-05 23.9 0.0 1.3e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.4 ESA15305.1 - 0.049 12.9 0.0 0.05 12.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) BTB PF00651.26 ESA15306.1 - 9.5e-19 67.4 0.6 2.3e-18 66.1 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15306.1 - 1.1e-13 51.3 4.1 1.9e-13 50.5 2.1 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15306.1 - 0.00015 21.5 0.0 0.002 17.9 0.0 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch YozD PF14162.1 ESA15306.1 - 0.14 12.2 1.4 13 5.9 0.0 2.7 2 0 0 2 2 2 0 YozD-like protein BTB PF00651.26 ESA15307.1 - 7e-20 71.0 0.5 1.8e-19 69.7 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15307.1 - 2.2e-13 50.3 3.0 2.2e-13 50.3 2.1 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15307.1 - 6.3e-07 29.1 1.5 1.6e-05 24.6 0.0 3.0 3 1 0 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA15308.1 - 1.8e-14 53.8 5.1 1.8e-14 53.8 3.5 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15308.1 - 0.00027 20.7 0.0 0.0055 16.5 0.0 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Myelin_PLP PF01275.14 ESA15308.1 - 0.051 12.8 0.1 0.082 12.2 0.1 1.2 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) BTB PF00651.26 ESA15309.1 - 1.6e-18 66.7 0.1 3.1e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15309.1 - 1.7e-08 34.5 2.4 6e-08 32.7 1.7 2.0 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA15309.1 - 0.00029 20.6 0.0 0.0034 17.2 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA15309.1 - 0.036 13.2 0.1 0.055 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) ENTH PF01417.15 ESA15311.1 - 9.8e-49 164.3 0.2 1.3e-48 164.0 0.1 1.1 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 ESA15311.1 - 3.1e-07 29.3 0.2 3.8e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 ANTH domain Biopterin_H PF00351.16 ESA15311.1 - 0.081 11.6 0.3 0.1 11.3 0.2 1.4 1 1 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase VHS PF00790.14 ESA15311.1 - 0.095 12.3 0.0 0.16 11.5 0.0 1.6 1 1 0 1 1 1 0 VHS domain HA2 PF04408.18 ESA15313.1 - 2.1e-25 88.7 0.0 4.1e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESA15313.1 - 2.7e-24 85.1 0.0 4.7e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold MAGSP PF03082.9 ESA15316.1 - 0.017 14.5 0.1 0.024 14.0 0.1 1.2 1 0 0 1 1 1 0 Male accessory gland secretory protein Pox_polyA_pol_N PF12630.2 ESA15316.1 - 0.99 9.5 6.0 1.9 8.6 0.7 2.2 1 1 1 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain MIR PF02815.14 ESA15317.1 - 0.0043 16.6 0.5 0.0085 15.6 0.3 1.5 1 1 0 1 1 1 1 MIR domain Tox-ART-HYD1 PF15633.1 ESA15317.1 - 0.07 13.9 0.3 0.18 12.6 0.2 1.7 1 0 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase DBD_Tnp_Mut PF03108.10 ESA15317.1 - 0.086 12.4 2.3 0.13 11.8 0.7 2.0 2 0 0 2 2 2 0 MuDR family transposase Antimicrobial19 PF08225.6 ESA15318.1 - 0.14 11.5 0.1 0.14 11.5 0.1 1.5 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Tap-RNA_bind PF09162.5 ESA15319.1 - 0.0029 17.1 0.0 0.0033 16.9 0.0 1.1 1 0 0 1 1 1 1 Tap, RNA-binding GluR_Homer-bdg PF10606.4 ESA15320.1 - 0.078 12.8 0.3 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 Homer-binding domain of metabotropic glutamate receptor Pkinase_Tyr PF07714.12 ESA15321.1 - 5.6e-29 100.9 0.0 9.6e-29 100.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15321.1 - 7.7e-26 90.7 0.0 1e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ARGLU PF15346.1 ESA15322.1 - 0.029 14.1 25.2 0.039 13.7 17.5 1.2 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 HAUS-augmin3 PF14932.1 ESA15322.1 - 0.35 10.0 19.6 0.43 9.7 13.6 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Macoilin PF09726.4 ESA15322.1 - 1.8 6.7 22.6 1.9 6.6 15.7 1.0 1 0 0 1 1 1 0 Transmembrane protein SpoIIIAH PF12685.2 ESA15322.1 - 2 7.8 17.2 2.1 7.7 11.9 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CENP-I PF07778.6 ESA15322.1 - 2.5 6.2 8.1 2.9 5.9 5.6 1.1 1 0 0 1 1 1 0 Mis6 eIF3_subunit PF08597.5 ESA15322.1 - 3.2 7.2 25.1 3.8 6.9 17.4 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Med17 PF10156.4 ESA15322.1 - 3.2 5.8 14.3 3.9 5.6 9.9 1.2 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DNA_pol3_a_NII PF11490.3 ESA15322.1 - 4.7 6.8 23.3 9.4e+02 -0.6 16.2 2.1 1 1 0 1 1 1 0 DNA polymerase III polC-type N-terminus II PCEMA1 PF07418.6 ESA15322.1 - 5.6 6.2 14.7 6.3 6.0 10.2 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 HSP70 PF00012.15 ESA15322.1 - 6.7 4.4 17.3 7.6 4.2 12.0 1.0 1 0 0 1 1 1 0 Hsp70 protein Asp-B-Hydro_N PF05279.6 ESA15322.1 - 8.9 6.0 21.6 10 5.9 15.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Atg14 PF10186.4 ESA15322.1 - 9.1 5.1 13.6 11 4.8 9.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 SH3_1 PF00018.23 ESA15324.1 - 1.6e-18 65.7 0.1 2.3e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA15324.1 - 8.4e-15 54.0 0.1 1.1e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA15324.1 - 3.4e-14 52.0 0.0 4.3e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain Ric8 PF10165.4 ESA15325.1 - 2.4e-100 336.4 0.1 3e-100 336.1 0.0 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn LRR_4 PF12799.2 ESA15326.1 - 3.9e-11 42.2 19.6 2.2e-05 23.9 0.4 6.9 4 3 3 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA15326.1 - 2.5e-10 39.8 1.5 6e-10 38.6 0.2 2.3 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.1 ESA15326.1 - 5.2e-09 35.2 24.7 1.7 8.9 0.2 9.8 7 2 1 9 9 9 4 Leucine Rich repeat F-box PF00646.28 ESA15326.1 - 4e-05 23.1 2.2 7.6e-05 22.2 0.0 2.7 3 0 0 3 3 3 1 F-box domain LRR_7 PF13504.1 ESA15326.1 - 0.00032 20.3 8.4 6.9 7.3 0.0 7.8 8 0 0 8 8 8 1 Leucine rich repeat LRR_1 PF00560.28 ESA15326.1 - 0.00059 19.5 20.8 15 6.0 0.1 9.2 7 2 0 7 7 7 1 Leucine Rich Repeat HEM4 PF02602.10 ESA15327.1 - 3.8e-40 137.5 0.0 4.3e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD zf-met2 PF12907.2 ESA15328.1 - 2.1e-17 62.8 1.9 3.1e-17 62.2 1.3 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.9 ESA15328.1 - 0.0011 19.6 9.2 0.0011 19.6 6.4 2.2 2 0 0 2 2 2 1 4F5 protein family DUF601 PF04642.7 ESA15329.1 - 0.03 13.6 6.2 0.031 13.6 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF601 Vfa1 PF08432.5 ESA15329.1 - 1.3 8.9 15.5 2.2 8.2 10.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PP2C_C PF07830.8 ESA15329.1 - 5.1 7.2 6.3 3.1 7.9 0.9 2.6 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain SH3_9 PF14604.1 ESA15330.1 - 9.6e-22 76.3 3.4 2.9e-13 49.1 0.2 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.23 ESA15330.1 - 1.6e-18 65.8 1.3 4.2e-10 38.8 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.12 ESA15330.1 - 5.9e-18 64.1 0.7 4.9e-08 32.3 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 ESA15330.1 - 1e-07 32.0 2.5 0.00053 20.1 0.1 2.4 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_4 PF06347.8 ESA15330.1 - 2.5e-07 30.1 2.9 5.3e-05 22.6 0.1 2.4 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_6 PF12913.2 ESA15330.1 - 3e-06 26.3 0.2 0.0047 16.1 0.0 2.5 2 0 0 2 2 2 2 SH3 domain of the SH3b1 type RA PF00788.18 ESA15330.1 - 0.0029 18.0 0.2 0.0078 16.6 0.0 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Pkinase_Tyr PF07714.12 ESA15331.1 - 2.5e-21 75.9 0.0 5.1e-20 71.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15331.1 - 2e-16 59.9 1.1 8.6e-16 57.8 0.7 2.1 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA15331.1 - 2.8e-06 27.1 0.1 0.0011 18.5 0.0 2.5 2 0 0 2 2 2 2 BCS1 N terminal APH PF01636.18 ESA15331.1 - 0.034 13.8 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family AIP3 PF03915.8 ESA15332.1 - 0.0043 16.0 0.4 0.0048 15.8 0.3 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 XPA_C PF05181.7 ESA15332.1 - 0.12 11.9 0.1 0.72 9.4 0.0 1.9 2 0 0 2 2 2 0 XPA protein C-terminus Tetraspannin PF00335.15 ESA15333.1 - 0.23 10.6 10.2 0.31 10.2 7.1 1.4 1 0 0 1 1 1 0 Tetraspanin family Pox_A9 PF04835.7 ESA15333.1 - 0.32 10.9 0.1 0.32 10.9 0.1 2.6 2 0 0 2 2 2 0 A9 protein conserved region YqhR PF11085.3 ESA15333.1 - 1 8.8 11.4 1.3 8.5 7.9 1.1 1 0 0 1 1 1 0 Conserved membrane protein YqhR Fumarate_red_C PF02300.12 ESA15334.1 - 0.06 13.2 0.5 0.075 12.9 0.3 1.1 1 0 0 1 1 1 0 Fumarate reductase subunit C S1 PF00575.18 ESA15335.1 - 7.7e-10 38.7 0.5 5.7e-09 35.9 0.2 2.4 2 0 0 2 2 2 1 S1 RNA binding domain DEAD PF00270.24 ESA15335.1 - 8e-09 35.2 0.0 1.9e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESA15335.1 - 9.8e-05 22.4 0.0 0.00029 20.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA15335.1 - 0.00014 20.9 0.1 0.00045 19.2 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.1 ESA15335.1 - 0.0024 17.4 0.0 0.014 14.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESA15335.1 - 0.024 14.5 0.1 0.25 11.2 0.0 2.4 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA15335.1 - 0.024 14.0 3.3 0.3 10.5 0.0 3.0 2 1 0 2 2 2 0 FtsK/SpoIIIE family ResIII PF04851.10 ESA15335.1 - 0.028 14.2 5.2 0.55 10.0 0.0 3.3 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.4 ESA15335.1 - 0.028 13.0 1.0 0.041 12.5 0.1 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Flavi_DEAD PF07652.9 ESA15335.1 - 0.066 12.9 0.5 0.19 11.4 0.0 2.1 3 0 0 3 3 3 0 Flavivirus DEAD domain AAA_29 PF13555.1 ESA15335.1 - 0.18 11.3 0.0 0.43 10.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PRP38_assoc PF12871.2 ESA15335.1 - 1.2 9.7 64.1 0.48 10.9 41.3 2.6 2 1 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term ABC_tran PF00005.22 ESA15335.1 - 1.2 9.4 6.6 0.3 11.3 0.1 3.0 2 2 1 3 3 3 0 ABC transporter ubiquitin PF00240.18 ESA15336.1 - 6.8e-26 89.4 0.1 7.5e-26 89.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA15336.1 - 2.1e-16 59.3 0.2 2.3e-16 59.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 ESA15336.1 - 0.00014 21.7 0.1 0.00031 20.6 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA15336.1 - 0.00014 22.0 0.0 0.00017 21.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.4 ESA15336.1 - 0.0023 18.0 0.0 0.0026 17.9 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UN_NPL4 PF11543.3 ESA15336.1 - 0.09 13.0 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Ribosomal_L7Ae PF01248.21 ESA15337.1 - 2.3e-25 87.9 0.1 2.8e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 ESA15337.1 - 0.0003 20.6 0.1 0.00035 20.4 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 ESA15337.1 - 0.041 13.6 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Cullin_Nedd8 PF10557.4 ESA15337.1 - 0.1 12.4 0.8 0.17 11.7 0.1 1.7 2 0 0 2 2 2 0 Cullin protein neddylation domain Ribosomal_L24e PF01246.15 ESA15338.1 - 1e-30 105.3 3.3 2.2e-30 104.2 2.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e tRNA-synt_His PF13393.1 ESA15338.1 - 0.039 13.0 0.1 0.046 12.7 0.1 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase DUF1825 PF08855.5 ESA15338.1 - 0.083 12.8 0.5 0.12 12.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) zf-FCS PF06467.9 ESA15338.1 - 0.19 11.3 2.9 0.32 10.6 2.0 1.3 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Fmp27_SW PF10305.4 ESA15338.1 - 0.25 11.7 2.9 0.88 10.0 0.7 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain LysM PF01476.15 ESA15339.1 - 1.2e-06 28.3 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 LysM domain UBA_4 PF14555.1 ESA15339.1 - 0.00059 19.3 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain zf-RING_5 PF14634.1 ESA15339.1 - 0.0017 18.0 10.2 0.0036 16.9 7.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA15339.1 - 0.0077 15.8 8.2 0.014 15.0 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.13 ESA15339.1 - 0.025 13.6 2.2 0.025 13.6 1.5 2.1 2 1 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-RING_2 PF13639.1 ESA15339.1 - 0.21 11.4 11.2 0.39 10.5 7.7 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 ESA15339.1 - 0.5 10.4 11.5 1.1 9.3 8.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Dimer_Tnp_hAT PF05699.9 ESA15340.1 - 1.3e-07 31.1 1.0 2.6e-07 30.1 0.1 2.0 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA15340.1 - 0.00052 19.5 0.1 0.0013 18.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.9 ESA15341.1 - 1.1e-06 28.1 0.1 2.3e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Erf4 PF10256.4 ESA15341.1 - 0.039 13.8 0.2 0.88 9.4 0.0 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family CENP-B_dimeris PF09026.5 ESA15341.1 - 0.46 10.7 12.3 1 9.6 8.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.7 ESA15341.1 - 0.57 9.3 4.5 0.77 8.9 3.1 1.2 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.13 ESA15343.1 - 1e-23 83.5 2.8 1.3e-23 83.2 2.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2392 PF10288.4 ESA15343.1 - 0.096 13.0 0.0 15 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2392) Thioredoxin PF00085.15 ESA15344.1 - 4e-33 113.1 3.1 3.2e-27 94.2 0.4 4.0 3 2 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 ESA15344.1 - 4.2e-14 52.7 11.2 4.9e-05 23.2 2.2 3.4 2 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESA15344.1 - 1.1e-11 44.6 1.6 2.2e-05 24.4 0.0 4.5 3 2 1 4 4 4 3 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA15344.1 - 6.5e-08 32.7 5.7 5.1e-05 23.4 1.5 3.9 1 1 1 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.16 ESA15344.1 - 0.00012 21.6 0.3 0.0016 18.1 0.1 2.6 2 0 0 2 2 2 1 AhpC/TSA family TraF PF13728.1 ESA15344.1 - 0.0058 16.1 3.4 1.6 8.1 0.0 3.6 4 0 0 4 4 4 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.1 ESA15344.1 - 0.015 15.2 0.1 0.074 13.0 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.1 ESA15344.1 - 0.021 14.6 0.1 0.28 11.0 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_4 PF13462.1 ESA15344.1 - 0.033 14.1 5.0 0.15 12.0 1.2 2.6 2 1 0 2 2 2 0 Thioredoxin Redoxin PF08534.5 ESA15344.1 - 0.042 13.4 0.1 0.18 11.3 0.1 2.0 2 0 0 2 2 2 0 Redoxin HyaE PF07449.6 ESA15344.1 - 0.11 12.3 0.0 0.62 9.9 0.0 2.2 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Rap_GAP PF02145.10 ESA15345.1 - 5.4e-55 185.6 0.0 1.2e-54 184.5 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP THOC7 PF05615.8 ESA15345.1 - 0.0045 17.2 0.6 0.0098 16.1 0.4 1.7 1 0 0 1 1 1 1 Tho complex subunit 7 GldM_C PF12080.3 ESA15346.1 - 0.0075 16.2 0.8 0.017 15.0 0.5 1.9 1 1 0 1 1 1 1 GldM C-terminal domain Ribonucleas_3_3 PF14622.1 ESA15347.1 - 1e-14 54.5 0.0 2.4e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 ESA15347.1 - 4.4e-07 30.3 0.4 4.4e-07 30.3 0.3 3.0 2 2 0 2 2 2 1 Ribonuclease III domain Mis12 PF05859.7 ESA15349.1 - 4.1e-24 85.0 0.9 4.1e-24 85.0 0.7 2.1 2 0 0 2 2 2 1 Mis12 protein ArsR PF09824.4 ESA15349.1 - 0.038 13.2 0.2 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 ArsR transcriptional regulator Phasin PF05597.6 ESA15349.1 - 0.17 11.6 0.1 0.17 11.6 0.1 1.9 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF904 PF06005.7 ESA15349.1 - 1.1 9.5 7.1 0.44 10.8 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF904) YkuI_C PF10388.4 ESA15349.1 - 1.3 8.7 5.9 6.3 6.4 1.1 2.1 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain DUF4616 PF15394.1 ESA15350.1 - 0.003 16.6 1.5 0.003 16.6 1.1 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4616) DUF4610 PF15384.1 ESA15350.1 - 0.24 10.9 2.6 0.3 10.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4610) TrbM PF07424.6 ESA15350.1 - 3.3 7.6 6.8 11 5.9 1.2 2.3 2 0 0 2 2 2 0 TrbM Glyco_hydro_101 PF12905.2 ESA15351.1 - 0.19 10.3 2.8 0.21 10.1 1.9 1.0 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase DUF792 PF05632.6 ESA15352.1 - 0.032 13.5 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) DUF1510 PF07423.6 ESA15353.1 - 0.01 15.1 0.1 0.012 15.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF3328 PF11807.3 ESA15353.1 - 0.011 15.4 0.0 0.012 15.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF2263 PF10021.4 ESA15355.1 - 2.3e-20 73.0 1.4 5.1e-20 71.9 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) UBA PF00627.26 ESA15355.1 - 3.2e-08 33.1 0.0 8.8e-08 31.7 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain DUF572 PF04502.8 ESA15356.1 - 1.1e-57 195.7 0.8 1.4e-57 195.4 0.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF106 PF01956.11 ESA15356.1 - 0.017 14.6 0.1 0.022 14.2 0.1 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF106 DUF866 PF05907.8 ESA15356.1 - 0.022 14.2 0.1 0.037 13.5 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) COX7C PF02935.11 ESA15357.1 - 2.7e-09 36.6 0.0 3e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc ECR1_N PF14382.1 ESA15358.1 - 6.3e-11 41.3 0.6 1.2e-10 40.5 0.4 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 ESA15358.1 - 0.00014 21.7 0.1 0.0054 16.6 0.1 2.4 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Lum_binding PF00677.12 ESA15359.1 - 0.058 13.2 0.2 0.091 12.6 0.1 1.4 1 0 0 1 1 1 0 Lumazine binding domain Helitron_like_N PF14214.1 ESA15361.1 - 9.2e-21 74.4 0.0 1.3e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus GlutR_N PF05201.10 ESA15361.1 - 0.038 13.5 0.0 0.09 12.3 0.0 1.6 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Piwi PF02171.12 ESA15362.1 - 5.6e-05 22.2 0.0 0.014 14.4 0.0 2.2 2 0 0 2 2 2 2 Piwi domain Poxvirus_B22R_N PF13169.1 ESA15362.1 - 0.13 12.4 0.3 0.42 10.8 0.0 1.8 2 0 0 2 2 2 0 Poxvirus B22R protein N-terminal Herpes_LMP1 PF05297.6 ESA15363.1 - 0.13 11.1 0.1 0.14 11.0 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) WD40 PF00400.27 ESA15366.1 - 1.4e-16 59.6 15.8 2.2e-05 24.1 0.0 7.4 8 0 0 8 8 8 5 WD domain, G-beta repeat Coatamer_beta_C PF07718.7 ESA15366.1 - 0.031 13.9 0.2 0.1 12.2 0.0 1.9 2 0 0 2 2 2 0 Coatomer beta C-terminal region DHFR_2 PF06442.6 ESA15366.1 - 0.052 13.1 0.1 12 5.6 0.0 2.4 2 0 0 2 2 2 0 R67 dihydrofolate reductase TIP49 PF06068.8 ESA15367.1 - 2.2e-190 632.5 0.6 2.6e-190 632.3 0.4 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 ESA15367.1 - 8.2e-12 45.4 0.3 3.1e-07 30.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA15367.1 - 6.3e-10 38.5 1.4 1.7e-06 27.2 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESA15367.1 - 3.4e-06 27.1 0.0 0.022 14.7 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 ESA15367.1 - 1.7e-05 24.9 0.1 0.24 11.5 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESA15367.1 - 0.00021 20.9 0.0 0.00046 19.8 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 ESA15367.1 - 0.0013 18.2 0.3 0.0023 17.3 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESA15367.1 - 0.0014 18.3 0.1 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 ESA15367.1 - 0.0016 18.3 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA15367.1 - 0.0023 18.2 0.1 0.037 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain GvpD PF07088.6 ESA15367.1 - 0.0031 15.8 0.1 0.33 9.2 0.0 2.2 2 0 0 2 2 2 1 GvpD gas vesicle protein Mg_chelatase PF01078.16 ESA15367.1 - 0.0036 16.4 0.1 0.12 11.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 ESA15367.1 - 0.0079 15.3 0.4 0.019 14.0 0.3 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 ESA15367.1 - 0.0088 16.8 0.1 0.053 14.3 0.0 2.2 2 2 0 2 2 2 1 AAA domain DUF2075 PF09848.4 ESA15367.1 - 0.01 14.8 0.0 0.022 13.7 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 ESA15367.1 - 0.011 15.6 0.0 5.7 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ESA15367.1 - 0.011 15.5 0.0 0.33 10.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ESA15367.1 - 0.014 14.8 0.1 2.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 ESA15367.1 - 0.016 14.6 0.1 0.035 13.5 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Inositol_P PF00459.20 ESA15367.1 - 0.02 14.1 0.1 0.37 10.0 0.0 2.2 2 0 0 2 2 2 0 Inositol monophosphatase family DnaB_C PF03796.10 ESA15367.1 - 0.033 13.0 0.0 0.056 12.3 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ResIII PF04851.10 ESA15367.1 - 0.06 13.1 0.2 0.85 9.4 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MinE PF03776.9 ESA15367.1 - 0.084 12.3 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE Parvo_NS1 PF01057.12 ESA15367.1 - 0.12 11.1 0.0 0.25 10.1 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 BUD22 PF09073.5 ESA15368.1 - 0.22 10.5 8.8 0.29 10.1 6.1 1.1 1 0 0 1 1 1 0 BUD22 Na_trans_assoc PF06512.8 ESA15368.1 - 0.29 11.0 7.1 0.49 10.3 4.9 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Nop14 PF04147.7 ESA15368.1 - 0.55 8.0 10.2 0.68 7.7 7.1 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA15368.1 - 0.58 8.1 5.9 0.75 7.7 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.6 ESA15368.1 - 3.2 7.5 9.0 6.2 6.6 6.2 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.1 ESA15368.1 - 7 6.8 12.1 12 6.0 7.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) VTC PF09359.5 ESA15369.1 - 2.9e-104 348.0 2.3 4.3e-104 347.5 0.0 1.9 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 ESA15369.1 - 2e-24 86.8 15.0 3.3e-12 46.7 5.9 3.9 2 2 1 3 3 3 2 SPX domain DUF202 PF02656.10 ESA15369.1 - 2.8e-12 46.6 2.3 5.9e-12 45.6 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) Pox_polyA_pol_N PF12630.2 ESA15369.1 - 0.2 11.7 1.8 7.7 6.6 0.2 2.6 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Glyco_hydro_65N PF03636.10 ESA15372.1 - 0.0099 15.2 1.9 0.015 14.6 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain DUF3685 PF12452.3 ESA15375.1 - 0.037 13.2 0.1 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) NARP1 PF12569.3 ESA15375.1 - 0.12 11.0 0.0 0.16 10.7 0.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAD_binding_4 PF01565.18 ESA15376.1 - 5.2e-29 100.4 3.4 7.5e-29 99.9 2.4 1.2 1 0 0 1 1 1 1 FAD binding domain Phage_int_SAM_3 PF14659.1 ESA15376.1 - 0.043 14.0 2.4 0.087 13.1 1.7 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain MIG-14_Wnt-bd PF06664.7 ESA15378.1 - 0.052 12.3 1.7 0.052 12.3 1.1 1.1 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion TLD PF07534.11 ESA15379.1 - 4e-10 39.8 0.4 5.7e-10 39.3 0.3 1.2 1 0 0 1 1 1 1 TLD DUF3656 PF12392.3 ESA15381.1 - 0.0014 18.6 0.0 0.0016 18.5 0.0 1.1 1 0 0 1 1 1 1 Collagenase Sel1 PF08238.7 ESA15382.1 - 9.6e-78 254.9 32.8 1.2e-13 51.1 0.1 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA15382.1 - 5.8e-06 26.4 12.4 4.1 8.0 0.1 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15382.1 - 9.8e-05 22.2 16.6 0.43 10.8 0.0 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA15382.1 - 0.0054 16.3 32.3 0.0081 15.7 4.7 5.4 2 1 2 5 5 5 2 TPR repeat Sel1 PF08238.7 ESA15383.1 - 1.3e-170 550.1 98.5 7.6e-11 42.2 0.4 23.2 23 0 0 23 23 23 21 Sel1 repeat TPR_6 PF13174.1 ESA15383.1 - 2.6e-13 49.4 46.2 2 9.0 0.0 15.9 17 0 0 17 17 17 6 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA15383.1 - 8.5e-05 21.7 0.0 0.00019 20.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase WW PF00397.21 ESA15383.1 - 0.053 13.3 0.2 0.18 11.6 0.2 2.0 1 0 0 1 1 1 0 WW domain TPR_12 PF13424.1 ESA15383.1 - 0.076 12.9 44.1 0.41 10.6 0.9 11.4 8 5 1 9 9 9 0 Tetratricopeptide repeat PPR_2 PF13041.1 ESA15383.1 - 3.9 7.5 13.2 4.9 7.2 0.1 5.2 7 0 0 7 7 7 0 PPR repeat family MT-A70 PF05063.9 ESA15385.1 - 0.082 12.4 0.0 0.082 12.4 0.0 1.0 1 0 0 1 1 1 0 MT-A70 Metallophos PF00149.23 ESA15386.1 - 1.5e-06 27.7 3.8 8.4e-06 25.3 2.6 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Sel1 PF08238.7 ESA15387.1 - 5.3e-143 462.3 53.4 6.1e-13 48.9 0.1 12.4 13 0 0 13 13 13 12 Sel1 repeat TPR_6 PF13174.1 ESA15387.1 - 4.8e-09 36.0 23.9 4.3 8.0 0.0 11.0 11 0 0 11 11 11 3 Tetratricopeptide repeat SinI PF08671.5 ESA15387.1 - 0.39 10.1 19.5 15 5.1 0.0 8.5 10 0 0 10 10 10 0 Anti-repressor SinI MgrB PF13998.1 ESA15387.1 - 7 6.5 14.7 60 3.5 0.1 6.4 7 0 0 7 7 7 0 MgrB protein FYVE PF01363.16 ESA15388.1 - 1.7e-14 53.4 17.8 3.1e-14 52.6 10.3 2.5 2 1 0 2 2 2 1 FYVE zinc finger Cyc-maltodext_C PF10438.4 ESA15389.1 - 0.041 13.9 3.3 0.19 11.7 0.8 2.9 1 1 1 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain Prefoldin_3 PF13758.1 ESA15390.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Prefoldin subunit AAA_5 PF07728.9 ESA15391.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MFS_1 PF07690.11 ESA15392.1 - 5.3e-32 110.8 50.6 4.2e-24 84.9 24.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA15392.1 - 6.2e-08 31.6 37.9 1e-06 27.6 5.6 3.2 1 1 2 3 3 3 3 Sugar (and other) transporter ATG22 PF11700.3 ESA15392.1 - 5.5e-05 21.8 6.9 5.5e-05 21.8 4.8 2.4 1 1 1 2 2 2 1 Vacuole effluxer Atg22 like MRAP PF15183.1 ESA15392.1 - 0.075 12.6 1.3 0.22 11.1 0.0 2.5 2 1 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DUF2216 PF10226.4 ESA15393.1 - 0.0007 19.1 3.5 0.0007 19.1 2.5 1.7 1 1 0 1 1 1 1 Uncharacterized conserved proteins (DUF2216) Tropomyosin_1 PF12718.2 ESA15393.1 - 0.0099 15.7 14.7 0.013 15.3 10.2 1.3 1 0 0 1 1 1 1 Tropomyosin like DUF972 PF06156.8 ESA15393.1 - 0.02 15.2 13.7 0.029 14.7 7.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ATP_Ca_trans_C PF12424.3 ESA15393.1 - 0.036 14.4 0.5 0.65 10.3 0.0 2.5 2 1 0 2 2 2 0 Plasma membrane calcium transporter ATPase C terminal DUF812 PF05667.6 ESA15393.1 - 0.096 11.1 11.1 0.12 10.8 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2347 PF09804.4 ESA15393.1 - 0.26 10.5 4.4 0.35 10.0 3.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF2422 PF10337.4 ESA15393.1 - 0.26 10.0 5.9 0.34 9.6 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) DivIVA PF05103.8 ESA15393.1 - 0.31 11.1 9.1 0.53 10.3 5.9 1.7 1 1 0 1 1 1 0 DivIVA protein Lectin_N PF03954.9 ESA15393.1 - 0.83 9.0 8.5 0.35 10.2 3.4 1.9 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF904 PF06005.7 ESA15393.1 - 1.1 9.6 14.9 3.4 8.0 10.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF904) IncA PF04156.9 ESA15393.1 - 2.5 7.6 16.6 6.6 6.2 11.5 1.6 1 1 0 1 1 1 0 IncA protein FAST_1 PF06743.10 ESA15394.1 - 0.053 13.2 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Urb2 PF10441.4 ESA15397.1 - 0.026 14.1 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 Urb2/Npa2 family DUF788 PF05620.6 ESA15399.1 - 0.0095 15.8 0.3 0.011 15.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF788) Kelch_4 PF13418.1 ESA15400.1 - 4.8e-08 32.6 1.0 0.033 13.9 0.0 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA15400.1 - 4.2e-07 29.4 0.2 0.13 11.8 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA15400.1 - 1.3e-05 25.1 1.4 0.2 11.9 0.0 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA15400.1 - 0.00019 21.5 0.5 0.027 14.6 0.0 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA15400.1 - 0.00054 19.8 0.1 0.21 11.5 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA15400.1 - 0.0028 17.3 1.0 0.53 10.1 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.1 ESA15401.1 - 4.9e-10 39.0 2.0 2.7e-05 23.8 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA15401.1 - 1.6e-08 34.4 0.1 7.8e-05 22.7 0.0 2.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA15401.1 - 3.4e-08 33.3 0.6 0.0035 17.4 0.0 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ESA15401.1 - 1.2e-07 31.1 0.3 0.001 18.5 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 ESA15401.1 - 5.8e-06 26.1 0.4 0.021 14.7 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA15401.1 - 0.00033 20.2 0.9 0.011 15.5 0.0 2.9 3 0 0 3 3 3 1 Kelch motif DUF1938 PF09153.5 ESA15401.1 - 0.051 13.3 0.1 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1938) Kelch_5 PF13854.1 ESA15402.1 - 3.9e-07 29.8 1.4 0.024 14.5 0.0 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 ESA15402.1 - 4.4e-07 29.5 0.6 0.0017 18.0 0.0 3.6 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA15402.1 - 4.5e-07 29.7 0.9 0.033 14.3 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA15402.1 - 7.2e-07 29.2 0.1 0.022 14.8 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA15402.1 - 7.6e-06 25.3 2.8 0.019 14.4 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA15402.1 - 9.8e-05 21.9 0.5 0.51 10.2 0.0 4.6 4 1 0 4 4 4 1 Kelch motif ApbA_C PF08546.6 ESA15403.1 - 1.3e-26 92.9 0.0 2.2e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 ESA15403.1 - 2.8e-07 30.1 0.0 1.3e-06 27.9 0.0 2.1 2 1 1 3 3 3 1 Ketopantoate reductase PanE/ApbA Pkinase PF00069.20 ESA15404.1 - 8.2e-16 57.9 0.0 1e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15404.1 - 1.8e-10 40.3 0.0 2.2e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA15404.1 - 0.057 13.1 0.2 0.073 12.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA15404.1 - 0.13 11.2 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UBA PF00627.26 ESA15405.1 - 3.6e-08 32.9 0.3 5.5e-08 32.4 0.2 1.3 1 0 0 1 1 1 1 UBA/TS-N domain Pkinase_Tyr PF07714.12 ESA15406.1 - 0.033 13.2 0.2 0.087 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA15407.1 - 9.4e-39 133.0 0.1 1.4e-34 119.3 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA15407.1 - 3.6e-35 121.3 0.2 4.9e-29 101.2 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain DUF2599 PF10783.4 ESA15407.1 - 0.024 15.2 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) WaaY PF06176.6 ESA15407.1 - 0.049 12.8 0.1 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) MA3 PF02847.12 ESA15408.1 - 3.3e-07 29.9 0.0 6.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 MA3 domain zf-C3HC4_4 PF15227.1 ESA15410.1 - 3.1e-11 42.9 11.1 3.1e-11 42.9 7.7 2.7 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESA15410.1 - 7.4e-10 38.3 11.4 7.4e-10 38.3 7.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA15410.1 - 1.6e-09 37.4 9.8 1.6e-09 37.4 6.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA15410.1 - 2.3e-08 33.5 6.8 2.3e-08 33.5 4.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA15410.1 - 8.7e-08 32.0 11.9 8.7e-08 32.0 8.2 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA15410.1 - 0.00018 21.1 4.6 0.00065 19.3 3.2 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 ESA15410.1 - 0.00021 21.3 7.1 0.00021 21.3 4.9 2.7 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ESA15410.1 - 0.0012 18.4 10.1 0.0012 18.4 7.0 2.6 2 1 0 2 2 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESA15410.1 - 0.004 16.9 1.7 0.004 16.9 1.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger IBR PF01485.16 ESA15410.1 - 1 9.2 14.5 8.2 6.3 6.8 2.9 2 1 0 2 2 2 0 IBR domain DiS_P_DiS PF06750.8 ESA15410.1 - 1 9.1 7.8 1.8 8.3 1.4 2.8 2 1 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain PolC_DP2 PF03833.8 ESA15410.1 - 3.6 5.1 7.9 0.91 7.1 0.3 2.2 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 zf-RING_4 PF14570.1 ESA15410.1 - 4.7 6.8 23.5 0.032 13.8 6.6 3.0 2 1 1 3 3 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 ESA15410.1 - 7.7 6.5 15.3 0.5 10.3 5.7 2.7 2 2 0 2 2 2 0 FANCL C-terminal domain zinc_ribbon_2 PF13240.1 ESA15410.1 - 9.6 5.8 15.9 0.95 9.0 1.8 3.7 3 1 0 3 3 3 0 zinc-ribbon domain Ssu72 PF04722.8 ESA15412.1 - 0.0087 15.3 0.1 0.011 15.0 0.1 1.2 1 0 0 1 1 1 1 Ssu72-like protein Daxx PF03344.10 ESA15412.1 - 0.033 12.7 0.0 0.034 12.6 0.0 1.1 1 0 0 1 1 1 0 Daxx Family Leptin PF02024.10 ESA15412.1 - 0.061 12.9 0.5 0.42 10.2 0.3 1.9 1 1 0 1 1 1 0 Leptin DUF3644 PF12358.3 ESA15412.1 - 0.1 12.8 0.1 0.14 12.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3644) DDE_Tnp_4 PF13359.1 ESA15413.1 - 6.7e-05 22.5 1.1 0.00011 21.8 0.7 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Plant_tran PF04827.9 ESA15413.1 - 0.019 14.3 0.2 0.06 12.7 0.1 1.7 1 1 1 2 2 2 0 Plant transposon protein DUF506 PF04720.7 ESA15413.1 - 0.043 13.4 1.7 0.05 13.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) ubiquitin PF00240.18 ESA15414.1 - 4e-34 115.8 1.0 4e-34 115.8 0.7 1.6 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.14 ESA15414.1 - 1.4e-27 95.1 1.5 3.1e-27 94.1 1.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.3 ESA15414.1 - 2.1e-20 72.1 1.0 4.2e-20 71.2 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA15414.1 - 2.8e-06 27.5 0.5 2e-05 24.7 0.2 2.4 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA15414.1 - 0.00012 21.9 0.6 0.00024 20.9 0.4 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Telomere_Sde2 PF13019.1 ESA15414.1 - 0.00012 21.8 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Telomere stability and silencing DUF2407 PF10302.4 ESA15414.1 - 0.0019 18.3 0.7 0.0025 17.9 0.5 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain DUF2207 PF09972.4 ESA15414.1 - 0.018 13.6 0.5 0.021 13.4 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Stig1 PF04885.8 ESA15414.1 - 0.096 12.8 0.6 0.16 12.1 0.3 1.4 1 1 0 1 1 1 0 Stigma-specific protein, Stig1 zf-C2H2_3 PF13878.1 ESA15414.1 - 0.13 11.8 0.2 0.31 10.6 0.1 1.7 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Plexin_cytopl PF08337.7 ESA15414.1 - 0.19 9.9 2.8 1.7 6.8 0.1 2.2 1 1 0 1 1 1 0 Plexin cytoplasmic RasGAP domain U-box PF04564.10 ESA15415.1 - 3.5e-07 30.0 0.1 1.6e-06 27.9 0.0 2.1 1 0 0 1 1 1 1 U-box domain FYRC PF05965.9 ESA15415.1 - 5.1e-07 29.4 0.0 1.5e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 F/Y rich C-terminus zf-ZPR1 PF03367.8 ESA15416.1 - 3.1e-108 358.0 6.2 1.9e-56 189.6 1.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain NB-ARC PF00931.17 ESA15416.1 - 0.02 13.7 0.1 0.047 12.5 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain SPOUT_MTase_2 PF14419.1 ESA15416.1 - 0.084 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP zf-ribbon_3 PF13248.1 ESA15416.1 - 1.3 8.2 9.3 13 5.1 0.0 3.9 3 1 1 4 4 4 0 zinc-ribbon domain DUF2757 PF10955.3 ESA15416.1 - 1.8 8.8 6.0 2.3 8.4 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2757) DZR PF12773.2 ESA15416.1 - 1.9 8.3 10.1 3.5 7.5 0.7 3.4 2 1 1 3 3 3 0 Double zinc ribbon bZIP_2 PF07716.10 ESA15417.1 - 1.3e-06 28.0 10.6 3.1e-06 26.9 7.4 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 ESA15417.1 - 2.1e-05 24.3 21.4 0.00014 21.7 9.4 2.3 2 1 1 3 3 3 2 bZIP transcription factor Cep57_CLD_2 PF14197.1 ESA15417.1 - 0.035 14.0 3.8 0.035 14.0 2.7 2.0 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF1664 PF07889.7 ESA15417.1 - 0.11 12.2 0.9 0.16 11.8 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) OmpH PF03938.9 ESA15417.1 - 0.23 11.3 4.0 0.41 10.5 2.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tetraspannin PF00335.15 ESA15417.1 - 0.49 9.6 3.2 0.88 8.8 2.2 1.4 1 0 0 1 1 1 0 Tetraspanin family IncA PF04156.9 ESA15417.1 - 0.87 9.1 7.4 1.1 8.7 5.2 1.2 1 0 0 1 1 1 0 IncA protein DivIC PF04977.10 ESA15417.1 - 1.1 8.7 5.4 0.8 9.2 1.4 1.7 1 1 1 2 2 2 0 Septum formation initiator DUF87 PF01935.12 ESA15417.1 - 1.3 8.8 4.7 1.6 8.4 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF87 YlqD PF11068.3 ESA15417.1 - 1.9 8.5 7.6 0.51 10.3 2.6 2.0 1 1 1 2 2 2 0 YlqD protein SpoU_sub_bind PF08032.7 ESA15417.1 - 3.5 7.8 5.6 1 9.5 0.2 2.3 2 1 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DUF342 PF03961.8 ESA15417.1 - 3.8 5.8 8.9 1.4 7.1 4.2 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF342) DUF4094 PF13334.1 ESA15417.1 - 6.9 7.1 9.4 0.92 9.9 3.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Glyco_trans_1_4 PF13692.1 ESA15418.1 - 5e-23 81.7 0.0 1.5e-22 80.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 ESA15418.1 - 2.9e-13 49.6 0.0 6.9e-13 48.3 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ESA15418.1 - 1.3e-07 31.8 0.0 2.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 ESA15418.1 - 0.00017 21.8 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESA15418.1 - 0.028 14.1 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 LAGLIDADG_1 PF00961.14 ESA15418.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 LAGLIDADG endonuclease DUF2639 PF11121.3 ESA15420.1 - 0.21 11.1 4.1 25 4.4 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2639) SPT6_acidic PF14632.1 ESA15421.1 - 0.097 12.8 3.1 1.1 9.4 0.3 2.2 1 1 1 2 2 2 0 Acidic N-terminal SPT6 DDE_3 PF13358.1 ESA15422.1 - 3.6e-13 49.5 0.1 7.8e-10 38.6 0.0 2.9 2 1 1 3 3 3 2 DDE superfamily endonuclease DDE_Tnp_ISAZ013 PF07592.6 ESA15422.1 - 0.064 11.9 0.1 0.098 11.3 0.1 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF4231 PF14015.1 ESA15424.1 - 0.25 11.3 2.0 1 9.3 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF1474 PF07342.6 ESA15424.1 - 1.5 9.1 6.7 0.95 9.7 0.1 3.2 2 2 0 3 3 3 0 Protein of unknown function (DUF1474) Sel1 PF08238.7 ESA15425.1 - 6.9e-56 185.4 10.6 1.6e-11 44.4 0.3 6.3 6 0 0 6 6 6 6 Sel1 repeat EF-hand_10 PF14788.1 ESA15425.1 - 0.00033 20.2 0.5 0.14 11.8 0.0 3.8 4 0 0 4 4 4 1 EF hand DUF1125 PF06563.6 ESA15425.1 - 0.023 14.4 0.9 0.11 12.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1125) AdoMet_MTase PF07757.8 ESA15425.1 - 0.043 13.9 0.9 1.1 9.4 0.0 3.2 3 1 1 4 4 4 0 Predicted AdoMet-dependent methyltransferase TPR_11 PF13414.1 ESA15425.1 - 0.083 12.5 13.6 0.3 10.7 1.2 4.5 1 1 2 3 3 3 0 TPR repeat MIT PF04212.13 ESA15425.1 - 0.25 11.2 8.9 13 5.7 2.7 3.9 4 2 0 4 4 4 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ESA15425.1 - 1.8 9.5 6.6 1.7e+02 3.5 0.0 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat L27_N PF09060.5 ESA15425.1 - 2.2 8.1 0.0 2.2 8.1 0.0 3.3 5 0 0 5 5 5 0 L27_N SPRY PF00622.23 ESA15426.1 - 8.6e-09 35.5 0.2 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA15426.1 - 8.9e-06 25.6 1.8 3.1e-05 23.9 0.1 2.4 2 1 0 2 2 2 1 BTB/POZ domain Pkinase PF00069.20 ESA15428.1 - 4.8e-28 98.0 2.4 8e-28 97.2 1.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15428.1 - 1.8e-27 96.0 0.4 2.5e-27 95.5 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase p450 PF00067.17 ESA15429.1 - 5.7e-84 282.2 0.8 6.6e-84 282.0 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1542 PF07564.6 ESA15430.1 - 0.00047 20.1 0.8 0.00071 19.5 0.1 1.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA15430.1 - 0.018 14.8 0.5 0.022 14.5 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 ARL2_Bind_BART PF11527.3 ESA15430.1 - 0.025 14.3 0.6 0.029 14.1 0.4 1.1 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART zf-B_box PF00643.19 ESA15430.1 - 0.63 9.9 6.4 1.1 9.2 4.4 1.4 1 0 0 1 1 1 0 B-box zinc finger Pkinase_Tyr PF07714.12 ESA15431.1 - 2.1e-18 66.3 0.0 1.9e-17 63.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15431.1 - 1.8e-17 63.3 1.9 2.1e-17 63.1 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain NinF PF05810.7 ESA15431.1 - 0.038 13.8 1.5 0.097 12.4 1.0 1.7 1 0 0 1 1 1 0 NinF protein APH PF01636.18 ESA15431.1 - 0.19 11.4 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDE_1 PF03184.14 ESA15432.1 - 0.0017 17.5 0.2 0.0017 17.5 0.1 1.8 2 1 0 2 2 2 1 DDE superfamily endonuclease NDUF_B8 PF05821.6 ESA15434.1 - 2.1e-08 34.0 0.0 2.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DUF3867 PF12983.2 ESA15438.1 - 0.021 14.7 0.8 0.025 14.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3867) DUF1433 PF07252.6 ESA15438.1 - 0.097 12.8 0.4 0.37 11.0 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1433) BTB_2 PF02214.17 ESA15439.1 - 0.05 13.8 0.6 0.4 10.9 0.0 2.4 1 1 2 3 3 3 0 BTB/POZ domain Peptidase_M3_N PF08439.5 ESA15439.1 - 0.089 12.8 0.2 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Oligopeptidase F Imm5 PF14423.1 ESA15440.1 - 0.0031 17.1 0.1 0.0046 16.6 0.1 1.3 1 0 0 1 1 1 1 Immunity protein Imm5 DUF1832 PF08870.6 ESA15441.1 - 0.031 13.9 0.1 0.037 13.7 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1832) DUF4085 PF13315.1 ESA15441.1 - 0.043 13.1 0.3 0.049 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Drf_FH3 PF06367.11 ESA15441.1 - 0.06 12.7 0.5 0.084 12.2 0.4 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain DUF4004 PF13171.1 ESA15441.1 - 0.086 12.9 0.3 0.089 12.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4004) DUF3837 PF12939.2 ESA15441.1 - 0.13 12.2 0.6 0.19 11.7 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3837) PQ-loop PF04193.9 ESA15442.1 - 2e-39 132.9 15.4 4.6e-21 74.1 1.0 3.6 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.11 ESA15442.1 - 0.018 14.8 11.8 0.082 12.7 0.7 2.7 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange EMP70 PF02990.11 ESA15443.1 - 0.0089 14.5 5.8 0.011 14.2 4.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Sel1 PF08238.7 ESA15444.1 - 3.5e-89 291.3 44.4 5.6e-09 36.3 1.1 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA15444.1 - 0.00041 20.6 19.5 3.9 8.1 0.0 8.8 9 1 1 10 10 10 2 Tetratricopeptide repeat S_tail_recep_bd PF14928.1 ESA15444.1 - 0.016 15.4 2.3 0.093 12.9 0.1 3.0 2 1 1 3 3 3 0 Short tail fibre protein receptor-binding domain TPR_11 PF13414.1 ESA15444.1 - 0.14 11.8 26.2 0.084 12.5 0.3 6.2 4 2 2 6 6 6 0 TPR repeat EAF PF09816.4 ESA15445.1 - 0.093 12.7 0.5 1.1 9.2 0.1 2.5 2 1 0 2 2 2 0 RNA polymerase II transcription elongation factor zf-H2C2_5 PF13909.1 ESA15445.1 - 0.67 10.2 2.9 1.6 9.1 2.0 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain F-box-like PF12937.2 ESA15446.1 - 0.025 14.3 1.3 0.041 13.6 0.2 1.8 2 0 0 2 2 2 0 F-box-like BTB PF00651.26 ESA15448.1 - 4.4e-18 65.3 1.3 5e-18 65.1 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15448.1 - 5.3e-16 58.8 3.1 9.2e-16 58.0 1.8 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15448.1 - 8.9e-07 28.7 0.2 8.4e-06 25.5 0.0 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15449.1 - 1.3e-19 70.1 0.1 3.7e-19 68.7 0.1 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15449.1 - 2e-11 44.0 5.7 2.1e-07 30.9 3.0 3.4 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA15449.1 - 3.1e-05 23.7 0.1 0.00023 20.9 0.0 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15450.1 - 3.3e-18 65.6 1.6 3.7e-18 65.5 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA15450.1 - 5.7e-09 35.7 0.3 2e-08 34.0 0.1 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch TLD PF07534.11 ESA15450.1 - 6.2e-07 29.4 0.4 7.9e-06 25.9 0.0 2.6 3 0 0 3 3 3 1 TLD Myb_DNA-bind_2 PF08914.6 ESA15451.1 - 0.0017 18.1 0.1 0.07 12.9 0.0 2.5 2 0 0 2 2 2 1 Rap1 Myb domain Myb_DNA-bind_6 PF13921.1 ESA15451.1 - 0.0075 16.3 1.5 0.0075 16.3 1.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Colicin PF01024.14 ESA15451.1 - 0.12 11.9 0.5 0.18 11.3 0.4 1.3 1 0 0 1 1 1 0 Colicin pore forming domain Myb_DNA-binding PF00249.26 ESA15451.1 - 0.34 11.0 2.6 1.1 9.3 0.4 2.5 2 2 0 2 2 2 0 Myb-like DNA-binding domain PRCC PF10253.4 ESA15452.1 - 0.0063 17.2 0.5 0.0071 17.0 0.4 1.0 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting ROF PF07073.7 ESA15452.1 - 0.075 13.0 0.3 0.091 12.7 0.2 1.2 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) DUF777 PF05606.6 ESA15452.1 - 0.13 11.4 2.2 0.14 11.2 1.5 1.0 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF777) DUF4337 PF14235.1 ESA15452.1 - 0.29 10.9 1.8 0.32 10.8 1.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ion_trans PF00520.26 ESA15456.1 - 1.1e-05 24.7 22.6 1.7e-05 24.1 15.7 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 ESA15456.1 - 1.5 7.1 16.6 0.0098 14.3 4.4 2.0 2 0 0 2 2 2 0 Polycystin cation channel PGG PF13962.1 ESA15456.1 - 1.9 8.1 11.0 5.1 6.7 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function TatC PF00902.13 ESA15457.1 - 4.1 6.7 15.1 0.51 9.7 6.0 2.3 1 1 0 2 2 2 0 Sec-independent protein translocase protein (TatC) Kinesin PF00225.18 ESA15458.1 - 8.4e-94 313.9 10.0 8.4e-94 313.9 7.0 2.0 2 1 0 3 3 3 1 Kinesin motor domain ATG16 PF08614.6 ESA15458.1 - 0.0029 17.4 13.7 0.0029 17.4 9.5 2.9 2 2 1 3 3 3 1 Autophagy protein 16 (ATG16) LOH1CR12 PF10158.4 ESA15458.1 - 0.0086 15.8 1.5 0.031 14.0 1.1 2.1 1 0 0 1 1 1 1 Tumour suppressor protein AAA_22 PF13401.1 ESA15458.1 - 0.027 14.5 0.6 0.12 12.4 0.4 2.1 1 1 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.7 ESA15458.1 - 0.95 9.2 22.3 0.41 10.3 11.9 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Glyco_hydro_18 PF00704.23 ESA15459.1 - 4.4e-87 292.7 10.6 1.9e-86 290.6 7.4 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_C93 PF06035.6 ESA15459.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial transglutaminase-like cysteine proteinase BTLCP Peptidase_C39 PF03412.10 ESA15459.1 - 0.11 12.3 0.0 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Peptidase C39 family DUF3877 PF12993.2 ESA15460.1 - 0.046 13.2 1.3 0.065 12.7 0.9 1.3 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) DUF3332 PF11810.3 ESA15460.1 - 0.093 12.3 0.6 0.11 12.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) DUF3890 PF13029.1 ESA15460.1 - 0.17 11.9 2.4 0.36 10.9 1.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3890) IncA PF04156.9 ESA15460.1 - 0.25 10.9 9.1 0.37 10.3 6.3 1.3 1 0 0 1 1 1 0 IncA protein HSP33 PF01430.14 ESA15460.1 - 0.65 9.0 2.9 0.78 8.8 2.0 1.1 1 0 0 1 1 1 0 Hsp33 protein HSBP1 PF06825.7 ESA15460.1 - 4.8 6.8 7.6 2.2 7.8 0.2 3.0 3 1 0 3 3 3 0 Heat shock factor binding protein 1 Cation_ATPase_N PF00690.21 ESA15461.1 - 1.7e-16 59.4 0.0 2e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Gemini_AL1 PF00799.15 ESA15462.1 - 0.016 15.0 0.6 0.34 10.7 0.4 2.5 1 1 0 1 1 1 0 Geminivirus Rep catalytic domain DUF3718 PF12514.3 ESA15463.1 - 0.017 15.1 0.4 0.1 12.6 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3718) DUF346 PF03984.8 ESA15464.1 - 2.1 7.8 2.8 13 5.3 0.0 2.4 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) TGS PF02824.16 ESA15465.1 - 1e-22 79.7 0.1 2.1e-22 78.7 0.1 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 ESA15465.1 - 7.7e-21 74.2 0.1 1.4e-20 73.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA15465.1 - 9.5e-14 50.9 0.0 1.9e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 ESA15465.1 - 1.3e-05 25.0 0.1 0.084 12.6 0.0 2.4 1 1 0 2 2 2 2 Dynamin family Miro PF08477.8 ESA15465.1 - 0.0011 19.5 0.0 0.015 15.8 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein ArgK PF03308.11 ESA15465.1 - 0.0024 16.6 0.2 0.007 15.1 0.0 1.9 1 1 1 2 2 2 1 ArgK protein SRPRB PF09439.5 ESA15465.1 - 0.0051 16.0 0.0 0.0096 15.1 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 ESA15465.1 - 0.0083 16.1 0.6 0.015 15.3 0.0 1.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_28 PF13521.1 ESA15465.1 - 0.0096 15.8 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA15465.1 - 0.01 15.9 0.1 0.05 13.7 0.1 2.2 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 ESA15465.1 - 0.016 14.8 0.1 0.097 12.3 0.0 2.2 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zea_mays_MuDR PF05928.6 ESA15465.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) AAA_17 PF13207.1 ESA15465.1 - 0.02 15.6 1.8 0.22 12.3 1.2 2.4 1 1 0 1 1 1 0 AAA domain AIG1 PF04548.11 ESA15465.1 - 0.039 13.0 0.0 0.058 12.5 0.0 1.3 1 0 0 1 1 1 0 AIG1 family DUF258 PF03193.11 ESA15465.1 - 0.045 12.9 0.0 0.088 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_18 PF13238.1 ESA15465.1 - 0.093 13.0 0.9 0.25 11.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 ESA15465.1 - 0.13 11.6 0.6 1.1 8.7 0.0 2.5 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Pkinase_Tyr PF07714.12 ESA15467.1 - 1.1e-24 86.8 0.0 1.4e-16 60.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA15467.1 - 7.8e-17 61.2 0.0 1.3e-12 47.3 0.0 2.2 1 1 0 2 2 2 2 Protein kinase domain TCO89 PF10452.4 ESA15470.1 - 8.8e-06 24.9 0.0 1.1e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 TORC1 subunit TCO89 L1R_F9L PF02442.12 ESA15471.1 - 0.025 14.0 0.1 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses SAICAR_synt PF01259.13 ESA15472.1 - 9.5e-87 290.2 0.2 1.2e-86 289.9 0.2 1.1 1 0 0 1 1 1 1 SAICAR synthetase DZR PF12773.2 ESA15473.1 - 0.079 12.7 4.7 0.11 12.3 3.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESA15473.1 - 0.19 11.2 4.9 0.5 9.9 3.4 1.8 1 1 0 1 1 1 0 zinc-ribbon domain zf-AN1 PF01428.11 ESA15473.1 - 2 8.3 8.1 5.3 6.9 5.6 1.7 1 1 1 2 2 2 0 AN1-like Zinc finger phiKZ_IP PF12699.2 ESA15474.1 - 0.0025 16.7 2.6 7.2 5.4 0.0 3.5 4 0 0 4 4 4 3 phiKZ-like phage internal head proteins NOB1_Zn_bind PF08772.6 ESA15474.1 - 0.0032 17.2 8.5 1.4 8.8 0.1 3.4 3 0 0 3 3 3 2 Nin one binding (NOB1) Zn-ribbon like Fzo_mitofusin PF04799.8 ESA15474.1 - 0.0051 16.2 2.0 0.48 9.7 0.0 3.6 4 0 0 4 4 4 1 fzo-like conserved region zf-DBF PF07535.7 ESA15474.1 - 0.026 14.1 2.0 0.026 14.1 1.4 4.7 3 2 0 3 3 3 0 DBF zinc finger DUF4413 PF14372.1 ESA15474.1 - 0.03 14.2 15.3 1.6 8.7 0.1 5.2 6 0 0 6 6 6 0 Domain of unknown function (DUF4413) DUF551 PF04448.7 ESA15474.1 - 0.17 12.6 1.3 2.3 9.0 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF551) CENP-F_leu_zip PF10473.4 ESA15474.1 - 1.9 8.3 7.1 5.1 6.9 0.1 3.5 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3740 PF12548.3 ESA15474.1 - 5 7.3 11.6 2.2 8.5 1.2 2.9 3 1 0 3 3 3 0 Sulfatase protein UQ_con PF00179.21 ESA15476.1 - 9.2e-50 167.7 0.0 1.1e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PHD PF00628.24 ESA15477.1 - 3.1e-06 26.7 7.9 3.1e-06 26.7 5.5 2.5 2 0 0 2 2 2 1 PHD-finger zf-UBR PF02207.15 ESA15477.1 - 0.003 17.2 0.2 0.003 17.2 0.1 4.3 4 1 1 5 5 5 1 Putative zinc finger in N-recognin (UBR box) Prok-RING_2 PF14445.1 ESA15477.1 - 0.54 10.2 9.7 5.5 7.0 0.9 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 2 Ribosomal_L16 PF00252.13 ESA15478.1 - 1.2e-43 148.0 0.5 1.3e-43 147.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e APG5 PF04106.7 ESA15479.1 - 0.13 11.7 2.8 0.17 11.3 2.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg5 FlaG PF03646.10 ESA15479.1 - 0.23 11.6 0.0 0.23 11.6 0.0 2.7 2 1 1 3 3 3 0 FlaG protein Tho2 PF11262.3 ESA15480.1 - 0.00097 18.2 1.8 0.0018 17.4 0.7 1.9 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 DUF1748 PF08520.5 ESA15480.1 - 0.011 15.2 0.6 0.48 10.1 0.1 3.1 2 1 0 2 2 2 0 Fungal protein of unknown function (DUF1748) PFEMP PF03011.10 ESA15481.1 - 0.017 15.4 5.2 0.025 14.9 3.6 1.2 1 0 0 1 1 1 0 PFEMP DBL domain IFNGR1 PF07140.6 ESA15481.1 - 0.076 12.7 5.7 0.069 12.8 2.7 1.7 1 1 1 2 2 2 0 Interferon gamma receptor (IFNGR1) Sec20 PF03908.8 ESA15481.1 - 0.82 9.4 5.9 2.5 7.8 1.4 2.5 1 1 2 3 3 3 0 Sec20 Pkinase_Tyr PF07714.12 ESA15482.1 - 3.6e-26 91.8 0.0 4.8e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15482.1 - 5.7e-26 91.2 0.0 9.8e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA15482.1 - 0.042 13.5 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DIL PF01843.14 ESA15483.1 - 0.018 14.9 1.7 1.1 9.1 0.0 3.2 3 0 0 3 3 3 0 DIL domain Gb3_synth PF04572.7 ESA15485.1 - 0.035 13.8 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 Alpha 1,4-glycosyltransferase conserved region DSPc PF00782.15 ESA15487.1 - 0.098 12.2 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain P22_AR_C PF10548.4 ESA15490.1 - 0.0041 16.9 0.1 0.0056 16.5 0.1 1.2 1 0 0 1 1 1 1 P22AR C-terminal domain DUF4180 PF13788.1 ESA15490.1 - 0.018 14.7 0.2 0.021 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4180) Nanovirus_C8 PF05629.6 ESA15490.1 - 0.032 14.0 0.4 0.037 13.8 0.3 1.0 1 0 0 1 1 1 0 Nanovirus component 8 (C8) protein DUF3723 PF12520.3 ESA15490.1 - 0.075 11.5 0.1 0.076 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) BTB PF00651.26 ESA15491.1 - 6.7e-17 61.4 0.3 1.7e-16 60.1 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15491.1 - 1.6e-14 54.0 1.2 2e-13 50.5 0.5 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15491.1 - 1.1e-06 28.4 2.6 0.00012 21.8 0.3 3.3 1 1 2 3 3 3 2 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA15491.1 - 0.018 15.2 0.1 0.066 13.4 0.0 1.9 1 1 1 2 2 2 0 BTB/POZ domain Rep_fac-A_C PF08646.5 ESA15492.1 - 7.7e-53 178.1 9.8 9.9e-49 164.7 4.6 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 ESA15492.1 - 1.1e-16 60.4 2.5 1e-12 47.7 0.0 3.1 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain Rep-A_N PF04057.7 ESA15492.1 - 2.5e-10 40.0 0.0 1.5e-09 37.5 0.0 2.3 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain Pox_A32 PF04665.7 ESA15492.1 - 0.0012 18.2 0.2 0.0031 16.8 0.1 1.7 1 0 0 1 1 1 1 Poxvirus A32 protein IBR PF01485.16 ESA15492.1 - 0.05 13.4 1.1 0.12 12.2 0.8 1.6 1 0 0 1 1 1 0 IBR domain Bac_small_YrzI PF09501.5 ESA15493.1 - 1 9.3 3.2 1.7 8.6 0.3 2.2 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) WSC PF01822.14 ESA15496.1 - 2.7e-25 88.1 30.9 1.5e-17 63.2 10.0 3.0 3 0 0 3 3 3 2 WSC domain PAN_3 PF08277.7 ESA15496.1 - 4.6 6.9 8.8 1.9 8.1 1.2 2.9 3 0 0 3 3 3 0 PAN-like domain Arb1 PF09692.5 ESA15498.1 - 7.7e-17 61.2 1.5 8.9e-15 54.4 0.0 2.9 1 1 2 3 3 3 3 Argonaute siRNA chaperone (ARC) complex subunit Arb1 PRP3 PF08572.5 ESA15498.1 - 0.099 12.0 0.5 0.13 11.6 0.3 1.1 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) Arb1 PF09692.5 ESA15499.1 - 1.5e-20 73.4 0.0 1.5e-20 73.4 0.0 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Pkinase_Tyr PF07714.12 ESA15500.1 - 2.3e-33 115.3 0.0 3.1e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15500.1 - 3.4e-32 111.6 0.0 4.5e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA15500.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA15500.1 - 0.011 14.8 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA15500.1 - 0.069 12.4 0.2 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.15 ESA15500.1 - 0.083 12.4 0.3 0.083 12.4 0.2 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase BTB PF00651.26 ESA15501.1 - 2.1e-18 66.2 0.3 2.6e-18 66.0 0.2 1.1 1 0 0 1 1 1 1 BTB/POZ domain YokU PF14122.1 ESA15503.1 - 0.018 14.7 0.1 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 YokU-like protein DUF2856 PF11043.3 ESA15504.1 - 0.099 12.7 0.3 0.16 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) zf-RING_2 PF13639.1 ESA15505.1 - 0.00013 21.7 23.0 0.0086 15.8 6.6 2.4 2 0 0 2 2 2 2 Ring finger domain Prok-RING_1 PF14446.1 ESA15505.1 - 0.0022 17.6 4.4 0.0022 17.6 3.1 2.8 2 1 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_5 PF14634.1 ESA15505.1 - 0.02 14.6 24.2 0.25 11.1 4.0 2.3 2 0 0 2 2 2 0 zinc-RING finger domain bcl-2I13 PF12201.3 ESA15505.1 - 0.04 13.3 0.9 0.077 12.4 0.2 1.7 2 0 0 2 2 2 0 Bcl2-interacting killer, BH3-domain containing zf-rbx1 PF12678.2 ESA15505.1 - 0.053 13.6 17.2 0.63 10.1 1.6 2.4 1 1 1 2 2 2 0 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA15505.1 - 0.066 13.2 23.1 0.96 9.5 8.0 2.8 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Apolipoprotein PF01442.13 ESA15506.1 - 0.0032 17.0 3.1 0.021 14.3 0.9 2.0 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain CreA PF05981.7 ESA15506.1 - 0.0089 15.5 0.4 0.012 15.1 0.3 1.3 1 0 0 1 1 1 1 CreA protein PEP-utilizers_C PF02896.13 ESA15506.1 - 0.093 11.5 0.1 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, TIM barrel domain DUF730 PF05325.6 ESA15506.1 - 0.91 9.3 5.5 0.23 11.2 0.8 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF730) Cob_adeno_trans PF01923.13 ESA15506.1 - 1.3 8.7 5.1 3.9 7.2 0.3 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Mitofilin PF09731.4 ESA15506.1 - 1.7 7.1 14.4 0.28 9.7 7.2 1.5 1 1 1 2 2 2 0 Mitochondrial inner membrane protein SprA-related PF12118.3 ESA15506.1 - 5.1 6.3 9.7 6.6 5.9 6.7 1.1 1 0 0 1 1 1 0 SprA-related family Exonuc_VII_L PF02601.10 ESA15506.1 - 7.7 5.6 14.4 9.6 5.2 10.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.4 ESA15507.1 - 0.00042 20.1 5.3 0.00042 20.1 3.7 1.6 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.16 ESA15507.1 - 0.00049 19.9 16.6 0.32 10.9 0.6 4.1 1 1 3 4 4 4 3 bZIP transcription factor PRTase_1 PF11202.3 ESA15507.1 - 0.029 13.3 0.7 0.039 12.9 0.5 1.1 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) DUF896 PF05979.7 ESA15507.1 - 0.11 12.0 6.9 0.056 13.0 1.3 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) HALZ PF02183.13 ESA15507.1 - 0.75 9.5 6.4 0.48 10.1 0.2 2.9 3 1 0 3 3 3 0 Homeobox associated leucine zipper ATG16 PF08614.6 ESA15507.1 - 1.2 8.9 8.3 2.3 7.9 2.6 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.1 ESA15507.1 - 4.6 7.2 7.4 8.1 6.4 3.3 2.5 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 zf-C4H2 PF10146.4 ESA15507.1 - 5.6 6.9 10.6 8 6.4 7.3 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Pkinase PF00069.20 ESA15508.1 - 1.2e-62 211.4 0.0 1.5e-62 211.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15508.1 - 1.9e-34 118.9 0.0 2.7e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA15508.1 - 1.1e-05 24.5 0.0 1.9e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like FHA PF00498.21 ESA15508.1 - 0.0003 20.8 0.2 0.00066 19.7 0.1 1.6 1 0 0 1 1 1 1 FHA domain Kdo PF06293.9 ESA15508.1 - 0.0034 16.4 0.0 0.0062 15.6 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 ESA15508.1 - 0.0039 16.0 0.5 0.0075 15.1 0.3 1.5 1 1 0 1 1 1 1 Poxvirus serine/threonine protein kinase RIO1 PF01163.17 ESA15508.1 - 0.004 16.5 0.2 0.0064 15.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA15508.1 - 0.13 11.6 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FA_desaturase PF00487.19 ESA15509.1 - 1.2 8.5 3.6 1.4 8.2 2.5 1.2 1 0 0 1 1 1 0 Fatty acid desaturase DUF1700 PF08006.6 ESA15509.1 - 1.2 8.3 10.3 1.5 8.0 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF2207 PF09972.4 ESA15509.1 - 1.6 7.2 4.5 1.6 7.2 3.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF898 PF05987.8 ESA15509.1 - 3.1 6.5 12.9 3.5 6.4 9.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Amastin PF07344.6 ESA15509.1 - 4.6 6.8 17.0 5.2 6.6 11.8 1.1 1 0 0 1 1 1 0 Amastin surface glycoprotein Adipogenin PF15202.1 ESA15509.1 - 4.9 7.0 5.2 1.4 8.8 1.5 1.7 1 1 1 2 2 2 0 Adipogenin SUR7 PF06687.7 ESA15509.1 - 4.9 6.6 11.3 5.6 6.4 7.8 1.2 1 0 0 1 1 1 0 SUR7/PalI family Caveolin PF01146.12 ESA15509.1 - 5.3 6.6 9.5 7 6.2 6.6 1.1 1 0 0 1 1 1 0 Caveolin Abhydrolase_9_N PF15420.1 ESA15509.1 - 8.7 6.0 17.3 11 5.7 12.0 1.1 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus FUSC-like PF12805.2 ESA15511.1 - 0.031 13.2 0.9 0.041 12.8 0.6 1.1 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Bromodomain PF00439.20 ESA15513.1 - 4.2e-18 65.0 0.3 6.4e-18 64.4 0.2 1.3 1 0 0 1 1 1 1 Bromodomain DUF3977 PF13122.1 ESA15513.1 - 0.036 13.8 0.1 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) Bromodomain PF00439.20 ESA15514.1 - 2.5e-16 59.3 0.3 2.6e-16 59.2 0.2 1.0 1 0 0 1 1 1 1 Bromodomain Sel1 PF08238.7 ESA15515.1 - 1.6e-155 502.1 60.3 2.7e-11 43.7 0.5 17.1 17 0 0 17 17 17 17 Sel1 repeat TPR_6 PF13174.1 ESA15515.1 - 1.5e-05 25.1 21.7 0.35 11.4 0.1 10.9 11 2 1 12 12 12 2 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA15515.1 - 0.17 11.6 2.6 6.6 6.5 0.0 3.4 3 0 0 3 3 3 0 Aurora-A binding FA_desaturase PF00487.19 ESA15516.1 - 2.8e-24 85.9 17.5 4.1e-24 85.3 12.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 ESA15516.1 - 1.6e-10 40.0 0.5 4.3e-10 38.6 0.1 2.0 2 0 0 2 2 2 1 Sphingolipid Delta4-desaturase (DES) MFS_1 PF07690.11 ESA15517.1 - 6e-12 44.9 45.2 1.5e-05 23.8 24.2 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase_Tyr PF07714.12 ESA15518.1 - 7e-42 143.2 0.0 8.7e-42 142.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15518.1 - 1.2e-36 126.1 0.4 1.5e-36 125.9 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA15518.1 - 1.2e-07 31.2 0.3 2e-07 30.5 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA15518.1 - 0.0054 15.8 0.1 0.0086 15.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA15518.1 - 0.025 13.9 0.3 0.051 12.9 0.2 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA15518.1 - 0.048 12.6 0.0 0.079 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA15518.1 - 0.19 11.4 0.4 0.75 9.4 0.3 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family BACK PF07707.10 ESA15519.1 - 6.1e-07 29.2 3.4 7.2e-05 22.5 1.0 3.0 1 1 2 3 3 3 3 BTB And C-terminal Kelch BTB PF00651.26 ESA15519.1 - 0.002 18.1 0.1 0.0036 17.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain RRM_6 PF14259.1 ESA15520.1 - 2.1e-10 40.3 0.0 1.9e-05 24.5 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA15520.1 - 2.1e-09 36.8 0.0 0.0018 17.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DASH_Dad3 PF08656.5 ESA15520.1 - 0.068 12.8 2.5 0.15 11.8 0.3 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad3 Exo_endo_phos PF03372.18 ESA15521.1 - 2.3e-15 57.2 0.1 2.8e-15 56.9 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA15521.1 - 4.6e-11 42.3 1.2 4.6e-11 42.3 0.8 1.9 2 1 1 3 3 3 1 Endonuclease-reverse transcriptase zf-RING_5 PF14634.1 ESA15522.1 - 8.8e-05 22.1 2.7 8.8e-05 22.1 1.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESA15522.1 - 0.0017 18.1 2.9 0.0017 18.1 2.0 1.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 ESA15522.1 - 0.0026 17.8 0.5 0.005 16.9 0.1 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger C1_1 PF00130.17 ESA15522.1 - 0.0034 17.0 0.5 0.074 12.8 0.0 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_UBOX PF13445.1 ESA15522.1 - 0.012 15.2 0.1 0.034 13.8 0.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.1 ESA15522.1 - 0.033 14.2 3.6 0.033 14.2 2.5 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 ESA15522.1 - 0.08 12.7 3.2 0.29 10.9 0.4 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4 PF00097.20 ESA15522.1 - 0.084 12.5 5.8 0.044 13.4 1.7 2.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DNA_RNApol_7kD PF03604.8 ESA15522.1 - 0.76 9.2 3.8 12 5.5 0.1 3.2 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Prok-RING_1 PF14446.1 ESA15522.1 - 1.1 9.0 7.0 2.5 7.8 2.0 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 IBR PF01485.16 ESA15522.1 - 2.3 8.1 5.1 2.8 7.8 1.0 2.5 1 1 1 2 2 2 0 IBR domain FAR1 PF03101.10 ESA15523.1 - 1e-11 45.1 2.2 1e-11 45.1 1.5 2.1 2 0 0 2 2 2 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA15523.1 - 0.00017 21.0 0.5 0.00058 19.3 0.1 2.0 2 0 0 2 2 2 1 MuDR family transposase Cys_rich_VLP PF14194.1 ESA15523.1 - 0.096 12.4 0.6 0.2 11.4 0.4 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP DUF4223 PF13978.1 ESA15525.1 - 0.034 13.8 1.4 0.069 12.8 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) Pkinase_Tyr PF07714.12 ESA15526.1 - 1.5e-07 30.7 0.0 0.011 14.8 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase BCS1_N PF08740.6 ESA15526.1 - 7.7e-07 28.9 0.0 0.12 12.0 0.0 4.1 4 0 0 4 4 4 2 BCS1 N terminal PTH2 PF01981.11 ESA15526.1 - 0.011 15.4 1.3 2.5 7.8 0.0 3.4 3 0 0 3 3 3 0 Peptidyl-tRNA hydrolase PTH2 Spt5-NGN PF03439.8 ESA15526.1 - 0.02 14.6 1.2 7.9 6.3 0.0 3.2 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section Frataxin_Cyay PF01491.11 ESA15526.1 - 0.098 12.4 6.0 2.1 8.1 0.0 3.8 4 0 0 4 4 4 0 Frataxin-like domain DUF4413 PF14372.1 ESA15526.1 - 0.46 10.4 6.8 6.4 6.8 0.1 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) Pkinase_Tyr PF07714.12 ESA15528.1 - 2.1e-20 72.8 0.1 4.4e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15528.1 - 3.7e-20 72.1 1.5 7.3e-20 71.1 1.0 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF4413 PF14372.1 ESA15528.1 - 0.31 11.0 14.5 2.6 8.0 0.1 5.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) Spt5-NGN PF03439.8 ESA15528.1 - 6.1 6.6 8.3 12 5.7 0.0 4.4 5 0 0 5 5 5 0 Early transcription elongation factor of RNA pol II, NGN section AAA PF00004.24 ESA15529.1 - 1.3e-30 106.2 0.0 1.1e-29 103.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA15529.1 - 4.3e-06 27.5 0.0 1.3e-05 26.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 ESA15529.1 - 2.3e-05 24.3 0.0 5.9e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 ESA15529.1 - 3.7e-05 23.7 0.0 9.6e-05 22.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 ESA15529.1 - 0.00015 21.4 0.0 0.00047 19.8 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 ESA15529.1 - 0.00018 21.2 3.4 0.00077 19.2 0.2 3.1 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESA15529.1 - 0.00035 20.8 0.2 0.0024 18.1 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.1 ESA15529.1 - 0.00064 19.8 1.9 0.12 12.5 0.1 3.3 1 1 2 3 3 3 1 AAA domain KaiC PF06745.8 ESA15529.1 - 0.00066 18.8 0.0 0.025 13.6 0.0 2.2 2 0 0 2 2 2 1 KaiC IstB_IS21 PF01695.12 ESA15529.1 - 0.00086 18.7 0.0 0.0019 17.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.1 ESA15529.1 - 0.00092 19.2 0.1 0.0026 17.7 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESA15529.1 - 0.0012 18.8 0.4 0.0033 17.4 0.1 2.1 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.16 ESA15529.1 - 0.0025 17.0 0.1 0.006 15.7 0.0 1.6 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 ESA15529.1 - 0.0026 17.9 0.0 0.0057 16.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 ESA15529.1 - 0.0026 17.1 0.3 0.0093 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA15529.1 - 0.0036 16.4 0.0 0.0079 15.3 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin RuvB_N PF05496.7 ESA15529.1 - 0.0039 16.2 0.0 0.0086 15.1 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 ESA15529.1 - 0.0045 15.7 0.1 0.0095 14.6 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_11 PF13086.1 ESA15529.1 - 0.02 14.4 0.0 0.036 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESA15529.1 - 0.022 14.6 0.0 0.042 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 ESA15529.1 - 0.041 13.7 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SKI PF01202.17 ESA15529.1 - 0.05 13.4 0.2 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase T2SE PF00437.15 ESA15529.1 - 0.054 12.3 0.0 0.096 11.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.22 ESA15529.1 - 0.057 13.7 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.11 ESA15529.1 - 0.077 12.2 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.1 ESA15529.1 - 0.082 12.4 0.1 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESA15529.1 - 0.095 12.1 0.0 0.3 10.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 ESA15529.1 - 0.11 12.1 0.2 2.8 7.5 0.1 2.4 1 1 1 2 2 2 0 NACHT domain Lipase_GDSL_2 PF13472.1 ESA15529.1 - 0.14 12.3 0.0 0.37 10.9 0.0 1.8 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Uma2 PF05685.7 ESA15530.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 Putative restriction endonuclease DUF3990 PF13151.1 ESA15531.1 - 0.00038 19.8 0.0 0.00072 18.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) Bestrophin PF01062.16 ESA15533.1 - 1.2e-43 149.1 0.1 5.8e-22 77.9 0.0 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel DUF3981 PF13139.1 ESA15533.1 - 0.088 12.8 3.1 1.1 9.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3981) Dexa_ind PF15198.1 ESA15533.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.3 2 1 1 3 3 3 0 Dexamethasone-induced DSPc PF00782.15 ESA15534.1 - 5.6e-22 77.7 0.0 6.2e-22 77.6 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA15534.1 - 3.2e-05 23.4 0.0 3.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Cpn60_TCP1 PF00118.19 ESA15535.1 - 3.4e-143 477.8 16.2 3.9e-143 477.5 11.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RNA_pol_Rpb2_6 PF00562.23 ESA15535.1 - 0.053 12.2 0.2 0.079 11.6 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 6 DUF3767 PF12597.3 ESA15536.1 - 5.6e-30 103.4 0.7 4.8e-27 93.9 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3767) WD40 PF00400.27 ESA15537.1 - 9.5e-45 148.9 23.8 1.7e-10 40.3 0.1 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat eIF2A PF08662.6 ESA15537.1 - 2.4e-06 27.4 1.6 0.07 12.8 0.1 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF4221 PF13970.1 ESA15537.1 - 1.1e-05 24.9 0.0 7.3e-05 22.2 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4221) CLTH PF10607.4 ESA15537.1 - 0.0036 17.0 0.4 0.0074 15.9 0.2 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain CPSF_A PF03178.10 ESA15537.1 - 0.029 13.4 0.1 0.46 9.5 0.0 2.3 1 1 1 2 2 2 0 CPSF A subunit region PD40 PF07676.7 ESA15537.1 - 0.083 12.5 0.3 8.8 6.1 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF4581 PF15167.1 ESA15537.1 - 0.13 12.1 0.2 0.76 9.6 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4581) Peptidase_S26 PF10502.4 ESA15538.1 - 4.8e-08 32.6 0.0 8.8e-05 22.0 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.18 ESA15538.1 - 1.2e-06 28.0 0.0 3.3e-06 26.6 0.0 1.7 1 1 1 2 2 2 1 Peptidase S24-like MIP PF00230.15 ESA15540.1 - 3.6e-43 147.6 9.2 4.6e-43 147.3 6.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein DZR PF12773.2 ESA15540.1 - 0.014 15.2 4.2 0.023 14.4 2.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESA15540.1 - 0.035 13.5 8.6 0.066 12.7 6.0 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESA15540.1 - 0.35 10.1 6.4 0.66 9.2 4.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Pkinase PF00069.20 ESA15541.1 - 6.2e-33 114.0 2.6 7.2e-33 113.8 1.8 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15541.1 - 6.7e-30 104.0 0.3 7.7e-30 103.8 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 ESA15541.1 - 0.00019 20.8 0.3 0.00029 20.2 0.2 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA15541.1 - 0.0063 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA15541.1 - 0.0083 15.8 0.8 0.087 12.5 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA15541.1 - 0.031 13.6 2.3 0.049 12.9 0.9 1.8 1 1 1 2 2 2 0 RIO1 family MutS_IV PF05190.13 ESA15541.1 - 0.12 12.6 3.5 0.33 11.1 0.6 2.2 1 1 1 2 2 2 0 MutS family domain IV WaaY PF06176.6 ESA15541.1 - 0.79 8.8 8.2 1.6 7.9 5.7 1.5 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Bse634I PF07832.6 ESA15545.1 - 0.024 13.7 3.3 0.025 13.7 1.7 1.4 1 1 0 1 1 1 0 Cfr10I/Bse634I restriction endonuclease FliS PF02561.9 ESA15545.1 - 0.061 13.1 3.1 0.07 12.9 0.4 2.2 1 1 1 2 2 2 0 Flagellar protein FliS zf-CCHC_4 PF14392.1 ESA15545.1 - 0.25 11.0 1.7 2.1 8.1 0.1 2.9 1 1 2 3 3 3 0 Zinc knuckle Spore_YhcN_YlaJ PF09580.5 ESA15545.1 - 6 6.9 7.6 0.14 12.2 0.5 1.7 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Piwi PF02171.12 ESA15546.1 - 1.5e-56 191.5 0.3 1.1e-37 129.6 0.0 2.2 1 1 1 2 2 2 2 Piwi domain IL31 PF15209.1 ESA15546.1 - 0.037 13.6 0.0 2.7 7.6 0.0 2.4 2 0 0 2 2 2 0 Interleukin 31 DUF218 PF02698.12 ESA15546.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 DUF218 domain DUF1785 PF08699.5 ESA15547.1 - 3.5e-10 39.0 0.0 5.8e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) Sec8_exocyst PF04048.9 ESA15547.1 - 0.079 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain zf-met2 PF12907.2 ESA15548.1 - 0.06 13.3 0.1 0.071 13.0 0.0 1.1 1 0 0 1 1 1 0 Zinc-binding TLD PF07534.11 ESA15549.1 - 3e-10 40.2 1.2 4e-10 39.8 0.8 1.2 1 0 0 1 1 1 1 TLD Laminin_G_3 PF13385.1 ESA15550.1 - 1e-14 55.0 0.2 1e-14 55.0 0.2 2.0 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA15550.1 - 3.7e-08 33.1 0.0 2.4e-05 23.9 0.0 2.2 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA15550.1 - 4.1e-05 22.7 0.0 7.7e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor zf-BED PF02892.10 ESA15552.1 - 0.014 15.0 6.3 0.098 12.4 4.4 2.2 1 1 0 1 1 1 0 BED zinc finger UQ_con PF00179.21 ESA15553.1 - 4.1e-38 129.9 0.0 4.4e-38 129.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA15553.1 - 0.14 12.0 0.6 0.19 11.6 0.3 1.4 1 1 0 1 1 1 0 RWD domain Xylanase PF13201.1 ESA15554.1 - 0.18 10.5 6.5 0.65 8.7 0.6 2.1 1 1 1 2 2 2 0 Putative glycoside hydrolase xylanase DUF4419 PF14388.1 ESA15555.1 - 3e-70 236.8 0.5 3.2e-70 236.6 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Aldo_ket_red PF00248.16 ESA15557.1 - 1.6e-33 115.7 0.0 1.8e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FAA_hydrolase PF01557.13 ESA15558.1 - 1.5e-44 152.0 0.0 2e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.6 ESA15558.1 - 4.9e-11 42.5 0.1 1.4e-10 41.0 0.1 1.7 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal zf-Tim10_DDP PF02953.10 ESA15561.1 - 0.0031 16.7 0.1 0.0095 15.2 0.1 1.8 1 0 0 1 1 1 1 Tim10/DDP family zinc finger FKBP_C PF00254.23 ESA15562.1 - 1.9e-24 85.5 0.0 4e-24 84.4 0.0 1.5 1 1 1 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase GIT_SHD PF08518.6 ESA15563.1 - 4.9e-25 86.5 4.8 1.3e-12 46.7 0.8 2.5 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT DUF869 PF05911.6 ESA15563.1 - 3.5e-06 25.5 4.8 3.5e-06 25.5 3.3 3.2 2 2 1 3 3 3 1 Plant protein of unknown function (DUF869) HAP1_N PF04849.8 ESA15563.1 - 0.0011 17.9 18.8 0.0011 17.9 13.0 2.0 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Baculo_PEP_C PF04513.7 ESA15563.1 - 0.035 13.9 21.2 1.3 8.7 2.7 4.8 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 ESA15563.1 - 0.097 12.2 33.2 0.094 12.3 18.6 3.6 3 1 0 3 3 3 0 IncA protein Pox_A_type_inc PF04508.7 ESA15563.1 - 0.16 11.8 6.7 1.6 8.7 0.2 4.0 3 0 0 3 3 2 0 Viral A-type inclusion protein repeat TMCO5 PF14992.1 ESA15563.1 - 0.42 9.6 31.6 0.0095 15.1 12.5 3.7 3 1 1 4 4 4 0 TMCO5 family ERM PF00769.14 ESA15563.1 - 0.42 10.1 30.3 0.47 9.9 17.1 3.1 2 1 0 2 2 2 0 Ezrin/radixin/moesin family WD40_alt PF14077.1 ESA15563.1 - 0.99 9.0 5.1 16 5.2 0.1 3.8 4 0 0 4 4 4 0 Alternative WD40 repeat motif CHD5 PF04420.9 ESA15563.1 - 4.3 6.9 7.7 21 4.7 5.3 2.2 1 0 0 1 1 1 0 CHD5-like protein LMBR1 PF04791.11 ESA15563.1 - 6.7 5.1 8.6 12 4.3 6.0 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6 PF04111.7 ESA15563.1 - 7.2 5.5 28.8 1.1 8.2 16.7 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Tropomyosin PF00261.15 ESA15563.1 - 8.1 5.4 37.8 1.4 7.9 18.7 3.3 3 1 1 4 4 4 0 Tropomyosin THP2 PF09432.5 ESA15563.1 - 8.3 6.2 16.2 0.41 10.5 5.6 2.9 4 0 0 4 4 3 0 Tho complex subunit THP2 V_ATPase_I PF01496.14 ESA15563.1 - 8.6 4.0 24.8 0.019 12.8 9.1 2.3 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family SNARE_assoc PF09335.6 ESA15564.1 - 0.097 12.8 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 SNARE associated Golgi protein zf-LITAF-like PF10601.4 ESA15565.1 - 0.055 13.3 0.1 0.055 13.3 0.1 1.9 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Dimer_Tnp_hAT PF05699.9 ESA15567.1 - 2.4e-07 30.2 0.3 4.9e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sel1 PF08238.7 ESA15569.1 - 1.2e-86 283.2 36.4 2.7e-12 46.8 0.3 9.3 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA15569.1 - 0.00015 22.0 14.3 6.5 7.4 0.0 7.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15569.1 - 0.0012 19.4 1.7 25 5.7 0.0 4.9 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15569.1 - 0.021 15.0 21.2 2.2 8.7 0.1 8.1 8 2 1 9 9 9 0 Tetratricopeptide repeat TPR_5 PF12688.2 ESA15569.1 - 1.5 8.9 4.6 14 5.6 0.0 3.6 4 1 1 5 5 5 0 Tetratrico peptide repeat Dimer_Tnp_hAT PF05699.9 ESA15570.1 - 8.3e-14 50.9 0.1 8.5e-14 50.9 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Kinesin PF00225.18 ESA15571.1 - 2.3e-45 154.7 0.1 2.6e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA15571.1 - 0.1 11.4 0.0 0.18 10.6 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Kinesin PF00225.18 ESA15572.1 - 4.5e-65 219.5 0.4 1.7e-64 217.6 0.3 1.7 1 1 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA15572.1 - 0.063 12.1 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Kelch_5 PF13854.1 ESA15573.1 - 5e-11 42.2 0.6 0.00099 19.0 0.0 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA15573.1 - 3.1e-10 39.6 5.6 0.0018 18.0 0.2 4.5 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA15573.1 - 1.9e-08 34.1 6.5 0.00056 19.9 0.1 3.6 3 1 1 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA15573.1 - 6.8e-08 32.4 0.4 0.0034 17.5 0.0 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA15573.1 - 1.5e-07 30.8 0.8 0.018 14.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA15573.1 - 4.8e-06 26.0 0.3 0.2 11.2 0.4 3.2 3 0 0 3 3 3 2 Kelch motif Glyco_transf_7C PF02709.9 ESA15573.1 - 0.026 13.9 0.4 0.059 12.8 0.3 1.5 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase BCS1_N PF08740.6 ESA15574.1 - 1.1e-08 34.8 1.3 0.68 9.5 0.0 4.7 5 0 0 5 5 5 4 BCS1 N terminal phiKZ_IP PF12699.2 ESA15574.1 - 0.15 10.9 6.6 4.6 6.0 0.0 3.9 5 0 0 5 5 5 0 phiKZ-like phage internal head proteins DUF4413 PF14372.1 ESA15574.1 - 0.18 11.8 16.0 7.3 6.6 0.1 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) ACCA PF03255.9 ESA15574.1 - 0.49 9.9 6.8 8.2 5.9 0.0 4.3 5 1 0 5 5 5 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CENP-F_leu_zip PF10473.4 ESA15574.1 - 0.69 9.7 9.1 22 4.9 0.1 4.4 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Med4 PF10018.4 ESA15574.1 - 3.4 7.0 8.0 3.2 7.1 0.0 3.6 4 0 0 4 4 4 0 Vitamin-D-receptor interacting Mediator subunit 4 zf-DBF PF07535.7 ESA15574.1 - 6.4 6.5 17.0 14 5.4 2.3 4.9 4 2 0 4 4 4 0 DBF zinc finger OmpH PF03938.9 ESA15575.1 - 0.014 15.3 3.2 0.021 14.7 2.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) IncA PF04156.9 ESA15575.1 - 0.015 14.9 0.0 0.032 13.8 0.0 1.6 1 1 0 1 1 1 0 IncA protein Lge1 PF11488.3 ESA15575.1 - 0.031 14.4 1.9 0.052 13.7 1.3 1.3 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF4527 PF15030.1 ESA15575.1 - 0.034 13.4 0.1 0.048 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) HSBP1 PF06825.7 ESA15575.1 - 0.23 11.0 6.9 0.44 10.1 4.8 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 WXG100 PF06013.7 ESA15575.1 - 0.29 11.1 3.4 0.45 10.5 2.4 1.3 1 0 0 1 1 1 0 Proteins of 100 residues with WXG DUF1515 PF07439.6 ESA15575.1 - 0.38 10.5 1.6 0.69 9.7 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) ABC2_membrane_5 PF13346.1 ESA15575.1 - 4.5 6.5 46.5 2.8 7.1 17.2 3.1 2 1 1 3 3 3 0 ABC-2 family transporter protein PAT1 PF09770.4 ESA15576.1 - 3.6 5.7 34.6 4.3 5.4 24.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 HMG_box PF00505.14 ESA15577.1 - 0.014 15.6 0.2 0.024 14.8 0.1 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box Pox_C7_F8A PF03287.9 ESA15577.1 - 0.06 13.0 0.6 0.068 12.8 0.4 1.1 1 0 0 1 1 1 0 Poxvirus C7/F8A protein F-box-like PF12937.2 ESA15578.1 - 0.00086 18.9 0.8 0.00086 18.9 0.6 1.7 2 0 0 2 2 2 1 F-box-like GTP_EFTU PF00009.22 ESA15580.1 - 0.016 14.6 0.1 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain ubiquitin PF00240.18 ESA15580.1 - 0.016 14.5 0.0 0.063 12.6 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin family Peptidase_M48 PF01435.13 ESA15580.1 - 0.028 13.9 0.1 0.066 12.7 0.1 1.6 2 0 0 2 2 2 0 Peptidase family M48 Metallophos PF00149.23 ESA15581.1 - 0.0042 16.5 5.3 0.025 13.9 3.7 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pyr_redox_2 PF07992.9 ESA15582.1 - 9e-23 81.2 0.0 2.5e-22 79.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 ESA15582.1 - 1.9e-15 56.9 0.0 6.6e-12 45.6 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 ESA15582.1 - 2.7e-11 41.9 2.2 5.7e-05 22.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 ESA15582.1 - 5.1e-09 36.1 0.4 1.7e-08 34.4 0.2 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 ESA15582.1 - 7e-08 31.7 0.5 0.0012 18.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 ESA15582.1 - 5.3e-07 28.6 0.9 0.004 16.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 ESA15582.1 - 0.00013 21.4 0.4 0.067 12.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.1 ESA15582.1 - 0.00022 21.3 0.0 3.8 7.5 0.0 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Bunya_G1 PF03557.10 ESA15582.1 - 0.0066 14.3 0.0 0.0089 13.8 0.0 1.1 1 0 0 1 1 1 1 Bunyavirus glycoprotein G1 TrkA_N PF02254.13 ESA15582.1 - 0.056 13.4 0.2 27 4.7 0.0 3.7 4 0 0 4 4 4 0 TrkA-N domain zf-DHHC PF01529.15 ESA15583.1 - 4e-36 124.0 9.6 4e-36 124.0 6.7 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.2 ESA15583.1 - 2.2e-19 69.5 0.1 3.4e-13 49.7 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESA15583.1 - 2.5e-17 61.6 1.3 2.9e-07 29.9 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 ESA15583.1 - 9.7e-14 51.0 4.3 2.5e-08 33.9 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESA15583.1 - 2.6e-12 46.8 0.9 2.6e-05 24.5 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA15583.1 - 1.2e-09 37.4 0.2 0.011 15.8 0.0 4.2 3 0 0 3 3 3 3 Ankyrin repeat stn_TNFRSF12A PF12191.3 ESA15583.1 - 0.069 13.1 2.6 0.19 11.7 1.8 1.7 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF4209 PF13910.1 ESA15585.1 - 3.1e-21 75.2 2.3 3.9e-20 71.7 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) LXG PF04740.7 ESA15586.1 - 0.033 13.9 0.7 0.35 10.6 0.6 2.0 1 1 1 2 2 2 0 LXG domain of WXG superfamily RPEL PF02755.10 ESA15586.1 - 0.36 10.2 1.5 0.64 9.4 0.0 2.0 2 0 0 2 2 2 0 RPEL repeat FlaG PF03646.10 ESA15586.1 - 0.49 10.5 2.7 3.9 7.6 0.4 2.1 2 0 0 2 2 2 0 FlaG protein Ribosomal_S21e PF01249.13 ESA15587.1 - 9.9e-37 124.7 0.0 1.1e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e UPF0197 PF05251.7 ESA15588.1 - 3e-13 49.8 4.8 4.3e-13 49.3 3.4 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0197) PMP22_Claudin PF00822.15 ESA15588.1 - 0.1 12.2 0.8 0.11 12.1 0.6 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family DPM3 PF08285.6 ESA15588.1 - 0.13 12.1 2.6 0.15 11.9 1.8 1.1 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF4131 PF13567.1 ESA15588.1 - 0.46 9.8 2.6 0.53 9.6 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BTB_2 PF02214.17 ESA15589.1 - 0.00016 21.8 0.0 0.006 16.7 0.0 2.8 1 1 0 1 1 1 1 BTB/POZ domain NPR3 PF03666.8 ESA15590.1 - 0.24 9.8 4.5 0.32 9.4 3.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNase_H PF00075.19 ESA15592.1 - 1.4e-09 38.3 0.0 5e-09 36.5 0.0 1.9 1 1 0 1 1 1 1 RNase H RNase_H PF00075.19 ESA15593.1 - 3.4e-13 50.0 0.3 3.8e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 RNase H HTH_Tnp_Tc3_2 PF01498.13 ESA15594.1 - 0.0066 16.4 0.2 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 Transposase VHS PF00790.14 ESA15597.1 - 0.0079 15.8 0.5 0.073 12.7 0.0 2.4 2 0 0 2 2 2 1 VHS domain HypA PF01155.14 ESA15597.1 - 0.017 14.8 7.0 2 8.1 0.3 4.0 4 0 0 4 4 4 0 Hydrogenase expression/synthesis hypA family TF_Zn_Ribbon PF08271.7 ESA15597.1 - 0.12 11.6 8.0 1.2 8.5 0.2 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding Fork_head PF00250.13 ESA15599.1 - 0.094 12.7 0.1 0.22 11.6 0.0 1.6 2 0 0 2 2 2 0 Fork head domain FliD_C PF07195.7 ESA15601.1 - 0.0043 16.3 8.0 0.008 15.5 0.5 2.2 2 0 0 2 2 2 2 Flagellar hook-associated protein 2 C-terminus Peptidase_M75 PF09375.5 ESA15601.1 - 0.011 15.0 0.0 0.026 13.8 0.0 1.5 1 1 0 1 1 1 0 Imelysin Glyco_hydro_67M PF07488.7 ESA15601.1 - 0.026 13.4 3.3 0.45 9.3 0.4 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 middle domain EIF_2_alpha PF07541.7 ESA15601.1 - 0.074 12.7 1.2 0.38 10.4 0.1 2.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit Spidroin_MaSp PF11260.3 ESA15601.1 - 0.15 12.1 1.6 0.43 10.6 0.2 2.3 2 1 1 3 3 3 0 Major ampullate spidroin 1 and 2 DUF1886 PF09171.5 ESA15601.1 - 0.29 10.1 5.6 0.24 10.3 2.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1886) Myb_DNA-bind_3 PF12776.2 ESA15601.1 - 0.72 10.5 3.7 7.2 7.3 0.1 2.8 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain WIYLD PF10440.4 ESA15601.1 - 1.2 9.0 4.4 0.67 9.9 0.3 2.4 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain F-box-like PF12937.2 ESA15602.1 - 6.9e-06 25.6 4.9 3.2e-05 23.5 3.4 2.2 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA15602.1 - 0.092 12.3 11.9 0.24 11.0 0.3 4.9 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) F-box PF00646.28 ESA15602.1 - 1.4 8.6 7.8 1 9.0 3.4 2.5 2 1 0 2 2 2 0 F-box domain Myb_DNA-bind_6 PF13921.1 ESA15605.1 - 0.63 10.1 8.8 0.27 11.3 0.2 3.2 3 0 0 3 3 3 0 Myb-like DNA-binding domain Pkinase PF00069.20 ESA15606.1 - 2.4e-39 135.0 0.0 4.1e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15606.1 - 1.1e-23 83.5 0.0 2e-23 82.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.3 ESA15606.1 - 0.0043 16.6 0.2 0.013 15.1 0.1 1.8 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C terminal DUF2479 PF10651.4 ESA15606.1 - 0.019 14.4 1.5 0.038 13.5 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2479) Sel1 PF08238.7 ESA15607.1 - 3.7e-106 345.2 42.9 8e-11 42.2 0.8 10.3 10 0 0 10 10 10 10 Sel1 repeat TPR_11 PF13414.1 ESA15607.1 - 4.2e-13 48.7 46.9 0.00011 21.7 3.9 7.7 2 1 6 8 8 8 7 TPR repeat TPR_6 PF13174.1 ESA15607.1 - 1.4e-07 31.4 13.1 27 5.4 0.2 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15607.1 - 0.00046 20.0 24.4 1.9 8.4 1.2 8.4 3 1 5 8 8 8 4 Tetratricopeptide repeat PPR PF01535.15 ESA15607.1 - 0.00086 19.1 0.6 1.1e+02 3.0 0.0 6.3 7 0 0 7 7 7 0 PPR repeat MIT PF04212.13 ESA15607.1 - 0.0037 17.1 31.3 17 5.3 0.1 9.4 9 1 0 9 9 9 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.1 ESA15607.1 - 0.056 13.7 7.8 46 4.4 0.0 5.7 6 2 2 8 8 8 0 Tetratricopeptide repeat MA3 PF02847.12 ESA15607.1 - 0.19 11.4 0.4 55 3.5 0.0 3.7 2 2 3 5 5 5 0 MA3 domain DUF3047 PF11249.3 ESA15607.1 - 0.74 9.1 5.7 32 3.8 0.0 4.5 2 1 3 5 5 5 0 Protein of unknown function (DUF3047) TPR_17 PF13431.1 ESA15607.1 - 5.4 7.4 32.1 16 5.9 0.2 8.7 3 2 5 9 9 9 0 Tetratricopeptide repeat BTB PF00651.26 ESA15609.1 - 1.3e-14 54.1 0.4 2.2e-14 53.3 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15609.1 - 1.2e-13 51.2 1.1 1.2e-13 51.2 0.7 2.4 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA15609.1 - 4.5e-09 36.0 0.7 0.00028 20.6 0.0 3.6 2 1 1 3 3 3 3 BTB And C-terminal Kelch HMG_box PF00505.14 ESA15610.1 - 1.1e-05 25.6 2.5 2.7e-05 24.3 1.4 1.9 1 1 1 2 2 2 1 HMG (high mobility group) box U3_assoc_6 PF08640.6 ESA15610.1 - 0.013 15.2 0.2 0.033 13.9 0.0 1.7 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 Methyltransf_31 PF13847.1 ESA15613.1 - 1.6e-05 24.5 0.1 7e-05 22.4 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA15613.1 - 5.5e-05 23.5 0.0 0.00018 21.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA15613.1 - 7.3e-05 22.5 0.0 0.00032 20.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA15613.1 - 0.00032 21.0 0.0 0.00079 19.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA15613.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.7 ESA15613.1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA15613.1 - 0.05 14.1 0.0 0.1 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESA15613.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Acetyltransf_7 PF13508.1 ESA15614.1 - 3.8e-12 46.1 0.0 6e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA15614.1 - 3.6e-11 42.9 0.0 5.4e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESA15614.1 - 1.3e-06 28.5 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA15614.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein SAP PF02037.22 ESA15615.1 - 0.15 11.6 0.6 0.28 10.7 0.4 1.5 1 0 0 1 1 1 0 SAP domain Pkinase_Tyr PF07714.12 ESA15617.1 - 1.2e-30 106.4 0.0 1.3e-30 106.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15617.1 - 1.4e-29 103.0 0.0 1.6e-29 102.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA15617.1 - 0.00018 20.5 0.0 0.00022 20.3 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA15617.1 - 0.003 17.3 0.1 0.0091 15.7 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA15617.1 - 0.0079 15.4 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA15617.1 - 0.025 13.6 0.0 0.032 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA15617.1 - 0.063 12.6 0.0 0.085 12.1 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kelch_5 PF13854.1 ESA15618.1 - 6.1e-09 35.6 0.0 0.019 14.9 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA15618.1 - 6.2e-08 32.5 0.0 0.0046 17.0 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA15618.1 - 2.4e-07 30.3 0.1 0.0033 17.1 0.0 3.4 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA15618.1 - 1.4e-05 24.6 0.0 0.15 11.9 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA15618.1 - 9.6e-05 22.3 0.1 2.1 8.6 0.0 3.5 3 1 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESA15618.1 - 0.00063 19.2 0.1 1.2 8.7 0.0 3.3 4 0 0 4 4 4 2 Kelch motif TMEM154 PF15102.1 ESA15618.1 - 0.001 18.7 0.2 0.0017 18.0 0.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family DUF2393 PF09624.5 ESA15618.1 - 0.0052 16.3 0.5 0.0052 16.3 0.3 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF2393) DUF912 PF06024.7 ESA15618.1 - 0.0059 16.6 0.1 0.016 15.2 0.1 1.7 1 1 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1180 PF06679.7 ESA15618.1 - 0.0098 15.7 0.2 0.016 15.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) DUF508 PF04370.7 ESA15618.1 - 0.011 15.3 1.8 0.021 14.4 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Rax2 PF12768.2 ESA15618.1 - 0.013 14.7 4.6 0.28 10.3 3.2 2.3 1 1 0 1 1 1 0 Cortical protein marker for cell polarity RCR PF12273.3 ESA15618.1 - 0.013 16.0 1.1 0.029 14.9 0.8 1.6 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Herpes_gE PF02480.11 ESA15618.1 - 0.021 13.1 0.1 0.039 12.2 0.0 1.4 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E 7TM_GPCR_Srh PF10318.4 ESA15618.1 - 0.022 13.6 0.2 0.033 13.0 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh Sigma_reg_N PF13800.1 ESA15618.1 - 0.044 13.8 2.5 0.13 12.3 0.3 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Peptidase_M56 PF05569.6 ESA15618.1 - 0.047 12.6 0.2 0.065 12.1 0.2 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 NfeD PF01957.13 ESA15618.1 - 0.068 13.3 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF4381 PF14316.1 ESA15618.1 - 0.089 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.1 ESA15618.1 - 0.12 12.7 0.9 0.31 11.4 0.2 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ATP-synt_8 PF00895.15 ESA15618.1 - 0.13 12.4 1.2 0.51 10.5 0.0 2.6 3 0 0 3 3 2 0 ATP synthase protein 8 Baculo_VP91_N PF08475.5 ESA15618.1 - 0.42 9.9 3.0 0.25 10.6 0.5 1.7 2 0 0 2 2 2 0 Viral capsid protein 91 N-terminal DUF1426 PF07234.6 ESA15620.1 - 0.034 13.8 0.2 0.043 13.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1426) LrgA PF03788.9 ESA15620.1 - 0.04 13.6 0.1 0.058 13.0 0.1 1.3 1 0 0 1 1 1 0 LrgA family Voldacs PF03517.8 ESA15621.1 - 0.035 13.9 1.7 0.057 13.2 1.2 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling HMGL-like PF00682.14 ESA15621.1 - 0.13 11.9 0.8 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 HMGL-like DUF4611 PF15387.1 ESA15621.1 - 0.27 11.3 6.6 0.11 12.7 1.3 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Ly49 PF08391.5 ESA15624.1 - 1.2 9.2 7.1 5.4 7.1 0.9 2.1 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Pox_D5 PF03288.11 ESA15624.1 - 1.6 9.0 7.1 0.25 11.6 1.7 1.9 2 1 0 2 2 2 0 Poxvirus D5 protein-like PrgU PF09627.5 ESA15625.1 - 0.093 12.3 0.1 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 PrgU-like protein DDE_1 PF03184.14 ESA15626.1 - 0.0036 16.4 0.1 0.0054 15.8 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease ADIP PF11559.3 ESA15626.1 - 0.014 15.3 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Tn7_Tnp_TnsA_C PF08721.6 ESA15626.1 - 0.026 14.5 0.3 0.047 13.6 0.2 1.4 1 0 0 1 1 1 0 TnsA endonuclease C terminal DUF4361 PF14274.1 ESA15626.1 - 0.034 13.7 0.1 0.041 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4361) Aldo_ket_red PF00248.16 ESA15627.1 - 3e-71 239.5 0.0 3.5e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2370 PF10176.4 ESA15629.1 - 5.4e-75 251.7 7.8 1.3e-74 250.4 1.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2370) DUF2408 PF10303.4 ESA15630.1 - 0.00029 20.9 1.2 0.00064 19.8 0.5 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF2408) DUF1664 PF07889.7 ESA15630.1 - 0.00036 20.3 0.6 0.00068 19.4 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) DUF241 PF03087.9 ESA15630.1 - 0.029 13.8 0.2 0.054 12.9 0.1 1.6 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Cluap1 PF10234.4 ESA15630.1 - 0.056 12.6 0.1 0.089 11.9 0.1 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 Baculo_PEP_C PF04513.7 ESA15630.1 - 0.062 13.1 0.1 0.15 11.8 0.0 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Baculo_p24 PF05073.7 ESA15630.1 - 0.064 12.8 0.2 0.078 12.5 0.1 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Syntaxin PF00804.20 ESA15630.1 - 0.085 13.0 0.8 0.21 11.7 0.6 1.8 1 1 0 1 1 1 0 Syntaxin TFIID-18kDa PF02269.11 ESA15630.1 - 0.12 12.2 0.6 0.25 11.1 0.3 1.7 1 1 1 2 2 2 0 Transcription initiation factor IID, 18kD subunit RPA_interact_M PF14767.1 ESA15630.1 - 0.16 12.7 0.2 0.16 12.7 0.1 2.0 3 0 0 3 3 3 0 Replication protein A interacting middle FlaC_arch PF05377.6 ESA15630.1 - 0.28 11.1 5.1 0.56 10.1 1.1 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF2013 PF09431.5 ESA15631.1 - 4.3e-49 165.8 10.0 4.9e-49 165.6 3.5 2.7 2 1 0 3 3 3 1 Protein of unknown function (DUF2013) TLD PF07534.11 ESA15634.1 - 8.1e-09 35.5 0.6 7.7e-08 32.4 0.3 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15634.1 - 5.5e-07 29.3 0.3 9.1e-07 28.6 0.2 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 ESA15634.1 - 0.00015 21.7 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA15635.1 - 4.4e-11 42.7 0.0 9e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15635.1 - 1.5e-10 40.7 1.8 5e-08 32.7 0.2 3.1 3 1 1 4 4 4 2 BTB And C-terminal Kelch UvsY PF11056.3 ESA15635.1 - 0.05 13.7 0.6 0.15 12.1 0.1 2.0 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY BTB PF00651.26 ESA15636.1 - 1.2e-16 60.6 0.1 2.2e-16 59.8 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15636.1 - 9.8e-09 34.9 1.4 1.1e-06 28.3 0.2 3.2 2 1 2 4 4 4 2 BTB And C-terminal Kelch UvsY PF11056.3 ESA15636.1 - 0.035 14.2 0.3 0.12 12.4 0.1 1.9 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Pkinase_Tyr PF07714.12 ESA15637.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Lactamase_B_2 PF12706.2 ESA15639.1 - 3.7e-20 72.2 0.0 6.6e-20 71.4 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 ESA15639.1 - 4.9e-12 45.9 0.1 3.1e-11 43.2 0.0 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.1 ESA15639.1 - 0.00037 19.8 0.0 0.00076 18.9 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease PDEase_II PF02112.10 ESA15639.1 - 0.059 12.2 0.3 0.16 10.9 0.0 1.7 2 0 0 2 2 2 0 cAMP phosphodiesterases class-II PTH2 PF01981.11 ESA15640.1 - 6.4e-47 158.0 0.0 8e-47 157.7 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Aa_trans PF01490.13 ESA15641.1 - 4.7e-61 206.4 34.2 5.3e-61 206.3 23.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.8 ESA15641.1 - 4.9e-06 25.4 19.8 4.9e-06 25.4 13.7 2.7 1 1 1 2 2 2 1 Spore germination protein Peripla_BP_2 PF01497.13 ESA15642.1 - 2.7e-16 59.4 0.0 3.4e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Cytochrom_C1 PF02167.10 ESA15643.1 - 3e-88 295.1 0.0 3.4e-88 294.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 ESA15643.1 - 0.0016 18.5 0.0 0.0034 17.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 ESA15643.1 - 0.093 13.5 0.2 0.32 11.8 0.0 1.9 2 1 0 2 2 2 0 Cytochrome c LMBR1 PF04791.11 ESA15644.1 - 2.5 6.5 4.0 2.9 6.3 2.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Na_Ca_ex PF01699.19 ESA15647.1 - 1.4e-33 115.4 39.2 8.3e-20 70.8 6.5 2.9 2 1 1 3 3 3 2 Sodium/calcium exchanger protein DUF1980 PF09323.5 ESA15647.1 - 0.037 13.7 0.9 0.037 13.7 0.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1980) ATP-synt_8 PF00895.15 ESA15647.1 - 0.092 12.9 0.1 0.092 12.9 0.1 4.8 5 2 2 7 7 7 0 ATP synthase protein 8 Cyt-b5 PF00173.23 ESA15649.1 - 6.3e-25 86.7 0.0 1.3e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 ESA15649.1 - 6.1e-14 52.0 2.8 7.1e-14 51.8 1.1 1.6 2 0 0 2 2 2 1 Fatty acid desaturase TauE PF01925.14 ESA15649.1 - 0.02 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Ribosomal_S19 PF00203.16 ESA15649.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S19 LRR_4 PF12799.2 ESA15650.1 - 3.4 7.4 7.4 0.13 11.9 1.0 1.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF1626 PF07788.6 ESA15651.1 - 0.12 12.2 0.2 0.23 11.2 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1626) SKI PF01202.17 ESA15652.1 - 0.075 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase AAA_23 PF13476.1 ESA15652.1 - 0.15 12.3 7.5 0.2 11.9 5.2 1.1 1 0 0 1 1 1 0 AAA domain Dimer_Tnp_hAT PF05699.9 ESA15654.1 - 3.7e-11 42.4 0.2 6.1e-11 41.7 0.2 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3969 PF13108.1 ESA15654.1 - 0.0083 15.7 1.1 0.014 15.0 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3969) YbjN PF10722.4 ESA15655.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.5 2 0 0 2 2 2 0 Putative bacterial sensory transduction regulator GTP_EFTU PF00009.22 ESA15657.1 - 3.8e-39 134.0 0.0 6.2e-39 133.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 ESA15657.1 - 2.6e-38 129.9 0.3 5.7e-38 128.8 0.2 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 ESA15657.1 - 6.6e-13 48.5 0.4 1.8e-12 47.1 0.3 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 ESA15657.1 - 0.0043 16.9 0.0 0.012 15.5 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA15657.1 - 0.085 12.6 0.0 0.32 10.8 0.0 1.9 2 0 0 2 2 2 0 Dynamin family Exo_endo_phos_2 PF14529.1 ESA15658.1 - 3.9e-07 29.6 0.2 6.2e-07 29.0 0.2 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA15658.1 - 0.00073 19.5 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Minor_capsid_2 PF11114.3 ESA15659.1 - 0.031 14.1 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Minor capsid protein GP41 PF00517.12 ESA15659.1 - 0.075 12.5 0.5 0.093 12.2 0.3 1.2 1 0 0 1 1 1 0 Retroviral envelope protein LRR_7 PF13504.1 ESA15660.1 - 0.88 10.0 6.1 69 4.3 0.1 5.2 6 1 0 6 6 6 0 Leucine rich repeat PARP PF00644.15 ESA15661.1 - 2.4e-13 50.0 0.2 5e-08 32.6 0.0 2.5 2 1 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain DUF1768 PF08719.6 ESA15662.1 - 3.5e-32 111.3 0.6 3.5e-32 111.3 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1768) TLD PF07534.11 ESA15664.1 - 5.5e-14 52.3 2.2 1.4e-13 51.0 1.5 1.7 1 0 0 1 1 1 1 TLD Peptidase_M9 PF01752.12 ESA15665.1 - 0.024 13.5 3.5 0.028 13.3 2.4 1.1 1 0 0 1 1 1 0 Collagenase Pkinase_Tyr PF07714.12 ESA15666.1 - 3.1e-07 29.7 0.1 4.7e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15666.1 - 0.023 13.8 0.0 0.049 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain HSP70 PF00012.15 ESA15669.1 - 0.00049 18.1 0.0 0.0045 14.9 0.0 2.3 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESA15669.1 - 0.0008 18.0 0.0 0.11 11.0 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein TDH PF03347.8 ESA15670.1 - 0.0042 16.6 0.2 0.0052 16.3 0.2 1.2 1 0 0 1 1 1 1 Vibrio thermostable direct hemolysin GP40 PF11025.3 ESA15670.1 - 0.033 13.7 0.1 0.043 13.3 0.1 1.3 1 1 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium F1F0-ATPsyn_F PF10791.4 ESA15670.1 - 0.097 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi Opy2 PF09463.5 ESA15670.1 - 0.13 12.3 0.8 0.13 12.3 0.6 1.9 2 0 0 2 2 2 0 Opy2 protein PITH PF06201.8 ESA15670.1 - 0.15 11.8 4.6 0.2 11.3 3.2 1.4 1 1 0 1 1 1 0 PITH domain RNase_H PF00075.19 ESA15672.1 - 1.8e-11 44.5 0.0 2.9e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 RNase H CLN5 PF15014.1 ESA15672.1 - 0.017 14.4 0.2 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Ceroid-lipofuscinosis neuronal protein 5 zf-C3HC4_2 PF13923.1 ESA15674.1 - 0.26 11.3 4.1 2.4 8.2 0.1 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA15674.1 - 0.29 10.8 3.3 0.79 9.4 0.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HNH PF01844.18 ESA15675.1 - 0.033 14.0 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 HNH endonuclease Leptin PF02024.10 ESA15675.1 - 0.091 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Leptin HNH_5 PF14279.1 ESA15675.1 - 0.12 12.4 0.7 0.18 11.8 0.2 1.6 2 0 0 2 2 2 0 HNH endonuclease p450 PF00067.17 ESA15676.1 - 4e-87 292.6 2.9 4.5e-87 292.5 2.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LAGLIDADG_1 PF00961.14 ESA15676.1 - 0.029 14.9 10.2 0.12 12.8 0.2 2.9 3 0 0 3 3 3 0 LAGLIDADG endonuclease DUF1241 PF06840.6 ESA15677.1 - 0.051 12.8 0.3 0.059 12.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) DUF240 PF03086.9 ESA15679.1 - 0.42 10.2 6.4 0.84 9.2 4.4 1.6 1 1 0 1 1 1 0 MG032/MG096/MG288 family 2 DUF2296 PF10058.4 ESA15680.1 - 2.2e-19 68.9 1.3 3.7e-19 68.2 0.9 1.4 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) tRNA_anti-like PF12869.2 ESA15680.1 - 0.13 11.7 1.0 0.24 10.8 0.7 1.4 1 1 0 1 1 1 0 tRNA_anti-like Pkinase PF00069.20 ESA15682.1 - 0.054 12.6 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15682.1 - 0.059 12.4 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF21 PF01595.15 ESA15684.1 - 1.1e-35 122.5 0.4 1.6e-35 122.0 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 ESA15684.1 - 1.3e-09 37.6 0.1 0.00086 19.0 0.0 3.0 3 0 0 3 3 3 2 CBS domain T4_Gp59_C PF08994.5 ESA15684.1 - 0.021 14.9 0.0 0.056 13.6 0.0 1.7 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term Cullin_binding PF03556.10 ESA15687.1 - 0.04 14.0 0.3 0.072 13.2 0.2 1.4 1 0 0 1 1 1 0 Cullin binding Osteopontin PF00865.13 ESA15688.1 - 2.5 7.2 14.1 1.2 8.3 8.6 1.2 1 1 0 1 1 1 0 Osteopontin DUF3364 PF11844.3 ESA15689.1 - 0.0014 18.6 0.5 0.0034 17.3 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3364) TPR_2 PF07719.12 ESA15691.1 - 2.6e-22 76.8 23.1 0.03 14.2 0.0 9.5 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 ESA15691.1 - 2.1e-21 75.3 29.8 8e-08 31.8 0.7 6.1 3 2 2 6 6 5 5 TPR repeat TPR_1 PF00515.23 ESA15691.1 - 2.3e-16 58.6 40.8 0.0027 17.2 0.1 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15691.1 - 1e-10 41.9 0.0 0.042 14.5 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA15691.1 - 1.8e-10 40.9 1.9 0.047 14.0 0.0 5.8 4 2 1 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA15691.1 - 7.1e-09 35.6 28.4 2.5e-05 24.2 3.3 4.6 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESA15691.1 - 1.5e-06 28.2 0.0 21 6.1 0.0 6.5 3 2 4 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15691.1 - 2.5e-06 27.3 11.1 0.52 10.2 0.2 5.5 4 3 2 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA15691.1 - 4.5e-05 23.6 3.5 11 6.7 0.0 7.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESA15691.1 - 0.00023 20.9 0.0 2.8 7.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA15691.1 - 0.00036 20.1 37.8 0.0023 17.5 0.0 8.8 8 1 2 10 10 10 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15691.1 - 0.0007 19.5 24.3 1.7 9.0 0.1 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat ChAPs PF09295.5 ESA15691.1 - 0.0013 17.5 7.3 0.0067 15.2 0.3 3.2 2 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.1 ESA15691.1 - 0.0015 18.1 1.2 13 5.9 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-C3HC4_3 PF13920.1 ESA15691.1 - 0.0021 17.6 2.6 0.005 16.4 1.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA15691.1 - 0.0062 16.2 3.0 0.02 14.6 2.1 1.9 1 0 0 1 1 1 1 zinc-RING finger domain SHNi-TPR PF10516.4 ESA15691.1 - 0.027 13.7 0.1 21 4.4 0.0 3.8 3 0 0 3 3 3 0 SHNi-TPR zf-RING_UBOX PF13445.1 ESA15691.1 - 0.034 13.8 4.0 0.17 11.6 2.8 2.3 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.1 ESA15691.1 - 0.36 10.7 2.3 1.1 9.1 1.6 1.9 1 0 0 1 1 1 0 Ring finger domain DUF2341 PF10102.4 ESA15692.1 - 0.082 13.0 0.3 0.72 10.0 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2341) Transposase_21 PF02992.9 ESA15693.1 - 1.7e-12 46.9 0.0 1.8e-12 46.8 0.0 1.0 1 0 0 1 1 1 1 Transposase family tnp2 DUF1258 PF06869.7 ESA15693.1 - 0.099 11.7 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) Mitofilin PF09731.4 ESA15695.1 - 0.65 8.5 18.0 0.75 8.3 12.5 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein V_ATPase_I PF01496.14 ESA15695.1 - 2 6.2 7.1 2.2 6.0 4.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MIP-T3 PF10243.4 ESA15695.1 - 3.7 5.8 28.3 4.4 5.6 19.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 CPSF73-100_C PF11718.3 ESA15695.1 - 7.1 5.9 12.3 13 5.0 8.5 1.4 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Cnd3 PF12719.2 ESA15696.1 - 0.52 9.2 3.3 4.4 6.2 0.3 2.2 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain TPR_11 PF13414.1 ESA15697.1 - 5e-22 77.3 6.6 1.3e-11 43.9 0.1 2.6 1 1 3 4 4 4 4 TPR repeat TPR_2 PF07719.12 ESA15697.1 - 4.1e-18 63.7 4.2 3.9e-07 29.4 0.0 4.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 ESA15697.1 - 3.1e-17 61.3 6.2 1.4e-08 34.0 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA15697.1 - 4.4e-14 51.1 11.1 2.5e-07 29.9 0.1 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15697.1 - 5.4e-12 44.9 6.2 0.055 13.6 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15697.1 - 4e-08 33.0 3.2 8.9e-05 22.3 0.1 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15697.1 - 2.5e-07 31.2 0.0 1.3e-05 25.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA15697.1 - 2.7e-07 30.6 0.2 0.00032 20.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA15697.1 - 2.3e-06 27.6 5.9 0.00016 21.7 1.1 3.3 2 2 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 ESA15697.1 - 8.9e-05 22.7 0.0 0.11 13.1 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA15697.1 - 0.00012 21.8 0.0 0.52 10.2 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA15697.1 - 0.00033 20.9 0.1 0.16 12.2 0.3 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA15697.1 - 0.0031 17.2 0.2 0.99 9.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Caudo_TAP PF02413.12 ESA15697.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.6 1 1 0 1 1 1 0 Caudovirales tail fibre assembly protein Fis1_TPR_C PF14853.1 ESA15697.1 - 0.22 11.4 8.6 2 8.3 0.0 3.0 4 0 0 4 4 2 0 Fis1 C-terminal tetratricopeptide repeat Cystatin PF00031.16 ESA15697.1 - 0.28 11.3 1.3 10 6.3 0.0 2.4 2 0 0 2 2 2 0 Cystatin domain TPR_3 PF07720.7 ESA15697.1 - 0.67 9.8 11.1 0.79 9.5 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA15698.1 - 2e-27 94.6 22.0 2.2e-08 33.6 0.4 5.8 4 1 1 6 6 6 5 TPR repeat TPR_2 PF07719.12 ESA15698.1 - 8.5e-27 90.8 17.8 0.00057 19.6 0.0 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESA15698.1 - 1.2e-21 75.2 30.8 0.0013 18.2 0.1 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_19 PF14559.1 ESA15698.1 - 7e-15 55.1 1.9 0.00069 19.9 0.0 5.4 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA15698.1 - 5.8e-14 52.3 0.0 0.00017 22.1 0.1 5.1 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15698.1 - 7.1e-14 50.7 16.4 0.04 14.1 0.0 8.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 ESA15698.1 - 4.9e-13 48.4 0.0 0.55 11.0 0.0 7.4 5 3 3 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15698.1 - 8.3e-12 44.8 11.0 0.00081 19.2 0.1 5.6 3 2 4 7 7 7 5 Tetratricopeptide repeat Apc3 PF12895.2 ESA15698.1 - 6.3e-11 42.2 27.9 4.7e-05 23.4 2.2 5.3 2 2 4 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESA15698.1 - 1.3e-09 37.8 1.3 0.23 11.9 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA15698.1 - 6.7e-09 34.8 4.1 2.3 8.2 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 ESA15698.1 - 3.4e-07 30.0 0.0 0.22 11.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA15698.1 - 6.2e-07 28.7 26.6 0.33 10.8 0.0 8.1 7 1 1 8 8 8 4 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA15698.1 - 1.1e-05 25.2 13.5 2.2 8.2 0.0 7.0 6 1 1 7 7 7 2 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.5 ESA15698.1 - 0.00076 18.3 1.5 0.0043 15.8 0.2 2.4 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.1 ESA15698.1 - 0.0013 17.8 0.0 0.017 14.1 0.0 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA15698.1 - 0.0015 17.7 0.3 1 8.6 0.0 4.1 4 0 0 4 4 4 1 SHNi-TPR zf-C3HC4_3 PF13920.1 ESA15698.1 - 0.0039 16.8 3.1 0.01 15.5 2.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NARP1 PF12569.3 ESA15698.1 - 0.0044 15.8 9.2 0.031 13.0 0.4 3.2 2 1 2 4 4 4 2 NMDA receptor-regulated protein 1 zf-RING_5 PF14634.1 ESA15698.1 - 0.009 15.7 4.6 0.029 14.0 3.2 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA15698.1 - 0.048 13.3 4.2 0.26 11.0 2.8 2.4 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.1 ESA15698.1 - 0.95 9.3 4.2 3.1 7.6 2.9 2.0 1 0 0 1 1 1 0 Ring finger domain TPR_2 PF07719.12 ESA15699.1 - 7.7e-24 81.6 16.5 0.00037 20.1 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 ESA15699.1 - 3.2e-21 74.7 22.1 2.7e-06 26.9 0.3 5.4 5 0 0 5 5 5 5 TPR repeat TPR_1 PF00515.23 ESA15699.1 - 4.8e-16 57.6 32.5 3.3e-05 23.2 0.3 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESA15699.1 - 5.5e-08 32.0 36.4 0.00037 20.0 0.6 8.1 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESA15699.1 - 5.2e-07 29.5 14.9 0.19 11.6 0.1 5.9 3 1 4 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.1 ESA15699.1 - 5.5e-07 29.2 16.1 0.25 11.6 0.0 7.6 8 0 0 8 8 7 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA15699.1 - 4e-06 26.8 32.3 0.034 14.2 2.9 5.5 2 1 2 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 ESA15699.1 - 4.8e-06 27.0 0.0 2.8 8.7 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA15699.1 - 7e-05 23.1 0.0 8.2 7.3 0.0 6.2 3 2 5 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA15699.1 - 8.7e-05 22.7 1.9 0.43 11.1 0.0 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA15699.1 - 0.0012 19.1 0.8 1.5 9.1 0.0 4.7 3 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA15699.1 - 0.01 14.8 0.2 0.022 13.8 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA15699.1 - 0.33 10.8 7.8 37 4.4 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA15699.1 - 9.1 6.2 15.4 15 5.5 0.0 5.6 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat zf-BED PF02892.10 ESA15702.1 - 0.0061 16.2 0.2 0.013 15.2 0.1 1.5 1 0 0 1 1 1 1 BED zinc finger GATA PF00320.22 ESA15702.1 - 0.06 12.6 1.1 0.62 9.4 0.1 2.5 2 0 0 2 2 2 0 GATA zinc finger HTH_11 PF08279.7 ESA15702.1 - 0.37 10.4 3.0 0.43 10.2 0.2 2.7 3 0 0 3 3 3 0 HTH domain DUF262 PF03235.9 ESA15702.1 - 7.5 6.4 10.7 1.8 8.4 4.6 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF262 IPPT PF01715.12 ESA15704.1 - 0.079 11.9 0.1 0.079 11.9 0.1 1.0 1 0 0 1 1 1 0 IPP transferase HMG_box PF00505.14 ESA15706.1 - 3.3e-09 36.8 0.2 5.2e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA15706.1 - 1.1e-07 32.0 0.1 1.8e-07 31.3 0.1 1.3 1 0 0 1 1 1 1 HMG-box domain CPSF_A PF03178.10 ESA15707.1 - 0.072 12.1 0.0 0.076 12.0 0.0 1.0 1 0 0 1 1 1 0 CPSF A subunit region Adeno_E3_CR1 PF02440.10 ESA15708.1 - 0.71 9.3 4.4 3.3 7.2 0.2 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 DZR PF12773.2 ESA15711.1 - 0.038 13.8 0.6 0.057 13.2 0.4 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-UBR PF02207.15 ESA15711.1 - 0.055 13.1 1.9 0.091 12.4 1.3 1.3 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Tnp_zf-ribbon_2 PF13842.1 ESA15711.1 - 0.87 10.0 4.5 1.6 9.1 3.1 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Pkinase PF00069.20 ESA15712.1 - 2.2e-26 92.5 2.4 3.9e-26 91.7 1.7 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15712.1 - 9.7e-26 90.3 0.1 1.3e-25 89.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA15712.1 - 0.056 12.4 0.1 0.34 9.9 0.0 2.0 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA15712.1 - 0.18 11.5 0.1 0.26 10.9 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1014 PF06244.7 ESA15713.1 - 0.017 15.3 2.4 0.021 15.0 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1014) FAM131 PF15010.1 ESA15713.1 - 0.039 13.6 0.2 0.045 13.5 0.2 1.0 1 0 0 1 1 1 0 Putative cell signalling Acetyltransf_1 PF00583.19 ESA15714.1 - 5e-12 45.6 0.0 7.4e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 ESA15714.1 - 1.3e-06 28.0 0.0 2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 ESA15714.1 - 4.8e-06 26.6 0.2 9.4e-06 25.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA15714.1 - 0.00076 19.4 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA15714.1 - 0.00095 19.0 0.1 0.0019 18.0 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA15714.1 - 0.0018 18.3 0.0 0.0027 17.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA15714.1 - 0.0021 17.9 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-CCCH PF00642.19 ESA15716.1 - 1.8e-12 46.6 18.5 3.4e-07 29.7 1.7 3.9 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 ESA15716.1 - 9.5e-09 34.9 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA15716.1 - 5.9e-05 22.6 0.1 0.00021 20.8 0.0 1.9 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA15716.1 - 0.001 18.9 0.1 0.0048 16.8 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CART PF06373.6 ESA15716.1 - 0.075 12.9 2.1 2.1 8.3 0.3 2.6 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) CTC1 PF15489.1 ESA15717.1 - 2.9e-28 97.8 0.0 1.4e-14 52.5 0.0 5.0 4 1 0 4 4 4 4 CST, telomere maintenance, complex subunit CTC1 CTC1_2 PF15491.1 ESA15717.1 - 0.00011 21.2 0.0 0.00021 20.4 0.0 1.4 1 0 0 1 1 1 1 CST, telomere maintenance, complex subunit CTC1 DUF4539 PF15072.1 ESA15717.1 - 0.0096 15.5 0.0 14 5.4 0.0 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF4539) Rab5ip PF07019.7 ESA15720.1 - 5.6e-19 68.0 8.5 6.9e-19 67.7 5.9 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF788 PF05620.6 ESA15720.1 - 0.14 12.0 0.5 0.16 11.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF788) Tachystatin_B PF11478.3 ESA15721.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Zn_clus PF00172.13 ESA15721.1 - 0.15 11.9 2.6 0.28 11.1 1.8 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3371 PF11851.3 ESA15722.1 - 0.1 13.2 18.9 0.12 13.1 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3371) Peptidase_S15 PF02129.13 ESA15722.1 - 0.39 10.1 13.2 0.48 9.7 9.2 1.0 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Late_protein_L2 PF00513.13 ESA15722.1 - 0.86 8.3 11.7 0.85 8.4 8.1 1.0 1 0 0 1 1 1 0 Late Protein L2 DUF966 PF06136.8 ESA15722.1 - 0.95 8.8 18.6 1 8.6 12.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Na_trans_assoc PF06512.8 ESA15722.1 - 1 9.2 12.5 1.2 9.0 8.7 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Glyco_hydro_1 PF00232.13 ESA15722.1 - 1.7 6.7 7.0 1.9 6.6 4.9 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 SR-25 PF10500.4 ESA15722.1 - 2 7.8 15.0 2.4 7.5 10.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Med15 PF09606.5 ESA15722.1 - 2 6.4 40.5 2 6.5 28.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peptidase_C58 PF03543.9 ESA15722.1 - 2.9 7.3 18.1 3 7.2 12.5 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Peptidase_S30 PF01577.11 ESA15722.1 - 4 6.7 13.0 5 6.4 9.0 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease Plasmodium_Vir PF05795.6 ESA15722.1 - 4.6 6.3 8.3 5.2 6.1 5.8 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Neur_chan_memb PF02932.11 ESA15722.1 - 4.8 7.0 11.8 5 6.9 8.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lyase_8 PF02278.13 ESA15722.1 - 5.1 6.3 12.7 5.8 6.2 8.8 1.0 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain SID-1_RNA_chan PF13965.1 ESA15722.1 - 5.8 4.9 13.9 6.4 4.8 9.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TT_ORF1 PF02956.9 ESA15722.1 - 6.5 5.0 15.3 6.7 5.0 10.6 1.0 1 0 0 1 1 1 0 TT viral orf 1 Hom_end_hint PF05203.11 ESA15722.1 - 10 5.8 12.9 12 5.6 9.0 1.1 1 0 0 1 1 1 0 Hom_end-associated Hint XPG_N PF00752.12 ESA15723.1 - 2.2e-37 127.3 0.0 5.7e-37 126.0 0.0 1.7 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 ESA15723.1 - 1.9e-29 101.5 0.0 3.8e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 ESA15723.1 - 4.8e-06 26.7 0.0 1.3e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.1 ESA15723.1 - 0.052 13.7 0.0 0.19 11.9 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix domain HAD_2 PF13419.1 ESA15724.1 - 1.3e-19 71.1 0.0 2.2e-19 70.3 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA15724.1 - 3.8e-08 34.0 0.0 6.1e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA15724.1 - 1.6e-05 24.4 0.0 3.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Fusion_gly PF00523.13 ESA15724.1 - 0.03 12.4 0.0 0.04 11.9 0.0 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 GTP_cyclohydroI PF01227.17 ESA15725.1 - 1.5e-71 239.3 3.5 1.5e-43 148.1 0.5 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase I QueF PF14489.1 ESA15725.1 - 0.0012 18.7 0.0 0.0043 16.9 0.0 1.9 2 0 0 2 2 2 1 QueF-like protein SNO PF01174.14 ESA15727.1 - 5.4e-57 192.4 0.0 6.3e-57 192.2 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 ESA15727.1 - 2.2e-11 43.6 0.0 8e-11 41.7 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 ESA15727.1 - 1.1e-06 28.2 0.0 2.7e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.19 ESA15727.1 - 5.9e-06 25.8 0.0 8.4e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 ESA15727.1 - 0.00028 20.1 0.0 0.00041 19.6 0.0 1.4 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_S51 PF03575.12 ESA15727.1 - 0.00037 20.2 0.0 0.00057 19.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 Peptidase_C26 PF07722.8 ESA15727.1 - 0.025 13.9 0.1 0.47 9.8 0.0 2.6 2 1 0 2 2 2 0 Peptidase C26 TIM-br_sig_trns PF09370.5 ESA15727.1 - 0.05 12.6 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 TIM-barrel signal transduction protein CLTH PF10607.4 ESA15728.1 - 3.5e-37 127.2 3.8 9.5e-37 125.9 2.6 1.8 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 ESA15728.1 - 7.4e-06 25.5 1.3 1.5e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA15728.1 - 0.064 13.1 0.3 3.1 7.7 0.0 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Reo_sigmaC PF04582.7 ESA15728.1 - 0.14 11.3 1.6 0.14 11.2 0.3 1.5 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TLD PF07534.11 ESA15729.1 - 2.4e-20 72.9 0.1 5e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA15729.1 - 2.3e-18 66.2 0.0 4e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15729.1 - 8.1e-05 22.4 2.1 0.0035 17.1 0.6 3.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch Fumerase PF05681.9 ESA15732.1 - 0.0073 15.4 0.8 0.013 14.6 0.1 1.7 2 0 0 2 2 2 1 Fumarate hydratase (Fumerase) F-box-like PF12937.2 ESA15733.1 - 0.002 17.7 0.8 0.0045 16.6 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box-like PF12937.2 ESA15734.1 - 0.023 14.4 0.5 0.067 12.9 0.4 1.8 1 0 0 1 1 1 0 F-box-like p450 PF00067.17 ESA15735.1 - 1.5e-87 294.0 0.1 1.8e-87 293.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dimer_Tnp_hAT PF05699.9 ESA15736.1 - 0.00063 19.3 0.0 0.00096 18.7 0.0 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF1980 PF09323.5 ESA15737.1 - 0.046 13.4 1.1 0.06 13.0 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF3357 PF11837.3 ESA15737.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) SVM_signal PF12113.3 ESA15737.1 - 0.22 11.3 2.1 0.43 10.4 1.5 1.4 1 0 0 1 1 1 0 SVM protein signal sequence AAA_12 PF13087.1 ESA15739.1 - 5.9e-38 130.2 1.2 1.7e-37 128.7 0.9 1.9 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA15739.1 - 1.1e-28 100.4 5.8 3.7e-28 98.6 0.0 3.5 3 1 0 3 3 3 1 AAA domain DUF2075 PF09848.4 ESA15739.1 - 1.8e-07 30.4 0.2 0.0001 21.4 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 ESA15739.1 - 3.6e-07 29.8 0.0 7.7e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA15739.1 - 1.2e-05 24.9 0.0 0.0039 16.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain zf-C3HC4_2 PF13923.1 ESA15739.1 - 0.0051 16.8 0.6 0.0051 16.8 0.4 21.7 8 4 16 24 24 24 4 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.10 ESA15739.1 - 0.024 14.4 0.1 0.024 14.4 0.1 2.8 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESA15739.1 - 0.035 14.0 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain zf-RING_2 PF13639.1 ESA15739.1 - 0.1 12.4 0.0 0.1 12.4 0.0 16.4 10 5 7 18 18 18 0 Ring finger domain zf-RING_UBOX PF13445.1 ESA15739.1 - 0.19 11.4 0.0 0.19 11.4 0.0 18.2 12 3 8 20 20 20 0 RING-type zinc-finger LRR_8 PF13855.1 ESA15741.1 - 0.0014 18.2 4.6 0.035 13.8 0.1 3.3 3 1 0 3 3 3 2 Leucine rich repeat HECT_2 PF09814.4 ESA15742.1 - 0.021 13.5 0.8 0.025 13.2 0.6 1.1 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF4521 PF15021.1 ESA15742.1 - 0.071 12.7 0.1 0.39 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4521) GRP PF07172.6 ESA15744.1 - 3.9 8.0 10.3 8.2 6.9 7.2 1.6 1 1 0 1 1 1 0 Glycine rich protein family SOXp PF12336.3 ESA15746.1 - 0.062 13.9 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 SOX transcription factor Pkinase_Tyr PF07714.12 ESA15749.1 - 0.068 12.2 0.4 0.16 10.9 0.1 1.7 1 1 1 2 2 2 0 Protein tyrosine kinase DUF2653 PF10850.3 ESA15749.1 - 0.11 12.8 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Pup_ligase PF03136.10 ESA15752.1 - 0.065 11.8 0.0 0.065 11.8 0.0 1.0 1 0 0 1 1 1 0 Pup-ligase protein DUF2660 PF10859.3 ESA15753.1 - 0.37 11.0 2.4 0.66 10.2 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) DUF3464 PF11947.3 ESA15753.1 - 4.9 6.5 7.4 0.93 8.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3464) DOCK-C2 PF14429.1 ESA15754.1 - 0.046 13.3 0.2 0.052 13.1 0.1 1.1 1 0 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins DUF2217 PF10265.4 ESA15757.1 - 0.1 11.3 5.9 0.12 11.1 4.1 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Cor1 PF04803.7 ESA15758.1 - 0.071 12.8 0.6 0.074 12.8 0.4 1.1 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Sfi1_C PF10638.4 ESA15759.1 - 0.05 14.0 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 Spindle body associated protein C-terminus Cor1 PF04803.7 ESA15760.1 - 0.045 13.5 0.7 0.049 13.4 0.5 1.1 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Gemin7 PF11095.3 ESA15761.1 - 0.0058 16.3 0.1 0.01 15.5 0.1 1.3 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) YebO PF13974.1 ESA15761.1 - 1.9 8.3 7.4 0.45 10.3 2.6 1.8 2 0 0 2 2 2 0 YebO-like protein DUF3078 PF11276.3 ESA15762.1 - 0.073 13.2 0.1 0.098 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3078) CD20 PF04103.10 ESA15764.1 - 0.078 12.9 2.7 1.5 8.7 0.2 2.6 2 1 1 3 3 3 0 CD20-like family DUF2899 PF11449.3 ESA15764.1 - 0.36 9.9 4.0 0.27 10.3 1.4 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2899) MreB_Mbl PF06723.8 ESA15768.1 - 1.6e-05 23.6 0.0 0.076 11.6 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA15768.1 - 0.00021 19.3 0.0 0.0016 16.4 0.0 2.2 2 1 0 2 2 2 1 Hsp70 protein BcrAD_BadFG PF01869.15 ESA15768.1 - 0.021 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Ribosomal_S30AE PF02482.14 ESA15769.1 - 0.054 13.9 3.0 0.14 12.6 1.0 2.4 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein p450 PF00067.17 ESA15771.1 - 9.9e-79 265.0 0.0 1.2e-78 264.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA15772.1 - 2e-36 125.5 0.7 3.5e-35 121.4 0.0 2.6 1 1 1 2 2 2 1 Cytochrome P450 Kelch_4 PF13418.1 ESA15773.1 - 0.00075 19.2 0.8 0.95 9.2 0.0 2.6 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA15773.1 - 0.001 18.7 0.0 0.99 9.2 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.20 ESA15773.1 - 0.0019 17.6 0.2 0.25 10.9 0.0 2.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 ESA15773.1 - 0.0024 17.9 0.1 0.73 10.1 0.0 2.3 2 0 0 2 2 2 2 Kelch motif REV PF00424.13 ESA15774.1 - 0.048 13.5 0.4 0.048 13.5 0.3 2.3 2 1 0 2 2 2 0 REV protein (anti-repression trans-activator protein) F-box PF00646.28 ESA15775.1 - 6.2e-08 32.1 0.1 1.4e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA15775.1 - 3.8e-07 29.7 0.2 8.8e-07 28.5 0.2 1.7 1 0 0 1 1 1 1 F-box-like EXOSC1 PF10447.4 ESA15776.1 - 0.06 13.3 1.1 0.3 11.0 0.2 2.2 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 CTP-dep_RFKase PF01982.11 ESA15776.1 - 0.11 12.0 0.4 0.21 11.1 0.1 1.6 1 1 0 2 2 2 0 Domain of unknown function DUF120 TCR PF03638.10 ESA15776.1 - 7.3 6.5 20.3 1.5 8.7 11.3 1.8 2 0 0 2 2 2 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain RGS PF00615.14 ESA15777.1 - 6.9e-06 26.1 1.0 2.5e-05 24.3 0.7 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain TB2_DP1_HVA22 PF03134.14 ESA15777.1 - 0.045 13.4 0.1 0.045 13.4 0.1 3.0 3 0 0 3 3 3 0 TB2/DP1, HVA22 family TRAP_beta PF05753.9 ESA15777.1 - 0.41 9.7 1.9 0.43 9.7 0.1 1.9 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) RseC_MucC PF04246.7 ESA15777.1 - 1 8.9 5.2 7.2 6.1 0.3 2.6 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC AIG1 PF04548.11 ESA15778.1 - 1.7e-07 30.5 0.0 4.1e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA15778.1 - 3.4e-06 27.0 0.0 1.1e-05 25.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA15778.1 - 0.026 13.7 0.2 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA15778.1 - 0.029 14.6 0.9 0.072 13.3 0.6 1.9 1 1 0 1 1 1 0 ABC transporter Dynamin_N PF00350.18 ESA15778.1 - 0.047 13.5 1.1 0.52 10.1 0.0 2.5 2 0 0 2 2 2 0 Dynamin family Pkinase PF00069.20 ESA15778.1 - 0.16 11.0 3.4 0.24 10.5 0.1 2.3 2 0 0 2 2 2 0 Protein kinase domain Lipase_GDSL PF00657.17 ESA15779.1 - 5.8e-12 45.9 0.0 2.5e-11 43.8 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 ESA15779.1 - 8.1e-07 29.3 0.0 2.7e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CD34_antigen PF06365.7 ESA15780.1 - 0.00076 19.1 0.5 0.0012 18.5 0.2 1.5 1 1 0 1 1 1 1 CD34/Podocalyxin family TMEM154 PF15102.1 ESA15780.1 - 0.00086 19.0 0.9 0.00086 19.0 0.6 1.7 1 1 1 2 2 2 1 TMEM154 protein family SID-1_RNA_chan PF13965.1 ESA15780.1 - 0.0063 14.7 1.5 0.0068 14.6 1.0 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF3432 PF11914.3 ESA15780.1 - 0.011 15.7 0.6 0.028 14.4 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) Tetraspannin PF00335.15 ESA15780.1 - 0.014 14.6 0.0 0.063 12.5 0.0 1.8 1 1 1 2 2 2 0 Tetraspanin family DUF1632 PF07857.7 ESA15780.1 - 0.031 13.5 0.3 0.047 12.9 0.2 1.5 1 0 0 1 1 1 0 CEO family (DUF1632) EphA2_TM PF14575.1 ESA15780.1 - 0.052 13.9 0.1 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ninjurin PF04923.7 ESA15780.1 - 0.052 13.2 0.1 0.1 12.3 0.1 1.6 1 1 0 1 1 1 0 Ninjurin ASFV_J13L PF05568.6 ESA15780.1 - 0.083 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3365 PF11845.3 ESA15780.1 - 0.096 12.5 0.1 0.25 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) DUF912 PF06024.7 ESA15780.1 - 0.98 9.5 3.8 0.85 9.7 0.2 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ABC2_membrane_3 PF12698.2 ESA15780.1 - 2.9 6.8 6.3 4.5 6.1 0.2 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein Ly49 PF08391.5 ESA15780.1 - 4.3 7.4 5.4 1.1 9.4 0.3 2.3 2 1 1 3 3 3 0 Ly49-like protein, N-terminal region Pox_H7 PF04787.7 ESA15781.1 - 0.17 11.7 3.1 0.29 10.9 2.1 1.5 1 1 0 1 1 1 0 Late protein H7 Acetyltransf_7 PF13508.1 ESA15782.1 - 5.8e-12 45.6 0.1 1.1e-11 44.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA15782.1 - 1.4e-09 37.8 0.0 2.5e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 ESA15782.1 - 8.9e-05 22.4 0.3 0.00013 21.9 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA15782.1 - 0.00048 20.2 0.0 0.00073 19.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Phage_cap_E PF03864.10 ESA15782.1 - 0.026 13.4 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein E DUF1722 PF08349.6 ESA15782.1 - 0.027 14.3 0.6 0.11 12.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) DUF2570 PF10828.3 ESA15782.1 - 0.046 13.3 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Acetyltransf_9 PF13527.1 ESA15782.1 - 0.064 13.1 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain tRNA-synt_1g PF09334.6 ESA15783.1 - 8.3e-126 419.7 2.8 1.4e-125 419.0 2.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 ESA15783.1 - 5.1e-24 84.2 7.1 1.7e-11 42.8 0.2 3.3 1 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 ESA15783.1 - 2.1e-15 56.6 1.0 1.4e-07 30.9 0.2 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 ESA15783.1 - 1.7e-05 23.7 0.1 0.00022 20.1 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (R) Anticodon_1 PF08264.8 ESA15783.1 - 0.00061 19.5 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA F-box-like PF12937.2 ESA15784.1 - 0.00071 19.2 0.4 0.0022 17.6 0.1 2.0 2 0 0 2 2 2 1 F-box-like G-gamma PF00631.17 ESA15784.1 - 0.063 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 GGL domain DXP_synthase_N PF13292.1 ESA15786.1 - 0.096 11.5 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Calc_CGRP_IAPP PF00214.14 ESA15787.1 - 0.19 11.7 0.9 0.61 10.1 0.1 2.0 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family F-box PF00646.28 ESA15788.1 - 2.1e-07 30.3 0.0 5.2e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA15788.1 - 2.7e-06 26.9 0.1 2.7e-06 26.9 0.0 1.8 2 1 0 2 2 2 1 F-box-like Feld-I_B PF09252.5 ESA15790.1 - 0.062 13.2 0.0 5.7 6.9 0.0 2.6 1 1 1 2 2 2 0 Allergen Fel d I-B chain F-box-like PF12937.2 ESA15791.1 - 3.8e-05 23.3 1.0 3.8e-05 23.3 0.7 2.7 4 0 0 4 4 4 1 F-box-like TypeIII_RM_meth PF12564.3 ESA15791.1 - 0.22 11.5 4.1 3.8 7.5 0.2 3.2 3 1 1 4 4 4 0 Type III restriction/modification enzyme methylation subunit BTB PF00651.26 ESA15792.1 - 5.8e-16 58.4 0.2 5.6e-15 55.2 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA15792.1 - 1e-09 38.5 0.2 2.7e-09 37.1 0.1 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA15792.1 - 1.3e-05 24.9 4.1 8.7e-05 22.3 0.2 3.1 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF2435 PF10363.4 ESA15792.1 - 0.11 12.4 0.5 0.33 10.8 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) WH1 PF00568.18 ESA15793.1 - 0.11 12.1 0.9 17 5.1 0.1 2.9 2 1 1 3 3 3 0 WH1 domain WH1 PF00568.18 ESA15794.1 - 0.011 15.4 0.6 2.7 7.7 0.0 2.7 2 1 1 3 3 3 0 WH1 domain IMS PF00817.15 ESA15795.1 - 0.11 12.2 0.4 0.7 9.6 0.2 2.1 1 1 1 2 2 2 0 impB/mucB/samB family Zn_clus PF00172.13 ESA15796.1 - 2.7e-12 46.4 11.8 3.6e-12 45.9 8.1 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-FCS PF06467.9 ESA15796.1 - 1.9 8.2 8.2 3.9 7.1 2.0 2.3 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif F-box-like PF12937.2 ESA15798.1 - 0.0035 17.0 0.5 0.0085 15.7 0.4 1.7 1 0 0 1 1 1 1 F-box-like LRR_7 PF13504.1 ESA15799.1 - 0.2 11.9 6.1 26 5.6 0.0 5.2 6 1 0 6 6 6 0 Leucine rich repeat LRR_8 PF13855.1 ESA15799.1 - 0.44 10.3 12.7 0.78 9.5 0.6 3.3 3 1 1 4 4 4 0 Leucine rich repeat Pox_D5 PF03288.11 ESA15800.1 - 0.002 18.3 0.0 0.0045 17.2 0.0 1.6 1 0 0 1 1 1 1 Poxvirus D5 protein-like AdoMet_dc PF02675.10 ESA15801.1 - 0.066 13.1 0.0 0.066 13.1 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase BTB PF00651.26 ESA15804.1 - 4.2e-21 75.0 0.3 7.7e-21 74.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15804.1 - 1.7e-13 50.7 1.3 5.3e-13 49.1 0.4 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15804.1 - 5e-07 29.5 3.8 0.0033 17.2 0.1 4.4 3 1 2 5 5 5 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA15804.1 - 0.0094 15.1 0.1 0.015 14.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) C6_DPF PF10170.4 ESA15810.1 - 0.014 15.4 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich domain Lipocalin_3 PF12702.2 ESA15810.1 - 0.024 14.6 3.5 0.096 12.7 0.2 2.3 2 0 0 2 2 2 0 Lipocalin-like DUF2789 PF10982.3 ESA15810.1 - 0.027 14.4 0.2 9.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) DUF2535 PF10751.4 ESA15810.1 - 0.036 14.1 1.1 11 6.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2535) TolB_N PF04052.8 ESA15810.1 - 0.04 14.0 0.2 7.6 6.6 0.0 2.3 2 0 0 2 2 2 0 TolB amino-terminal domain Sortase PF04203.8 ESA15810.1 - 0.082 12.4 0.3 0.94 9.0 0.0 2.2 2 0 0 2 2 2 0 Sortase family UCR_6-4kD PF08997.5 ESA15810.1 - 0.14 11.8 0.6 23 4.7 0.0 2.7 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein DUF3046 PF11248.3 ESA15810.1 - 0.15 12.0 0.0 2.7 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3046) Dimer_Tnp_hAT PF05699.9 ESA15812.1 - 0.00084 18.9 0.1 0.003 17.1 0.0 1.9 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region gag_pre-integrs PF13976.1 ESA15813.1 - 0.047 13.3 0.4 0.11 12.1 0.2 1.7 2 0 0 2 2 2 0 GAG-pre-integrase domain Chromadorea_ALT PF05535.7 ESA15813.1 - 0.067 13.2 0.3 0.076 13.1 0.2 1.3 1 0 0 1 1 1 0 Chromadorea ALT protein DUF1708 PF08101.6 ESA15817.1 - 0.0045 15.8 0.8 0.0058 15.5 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Stanniocalcin PF03298.8 ESA15819.1 - 1.5e-05 24.1 3.3 1.9e-05 23.8 2.2 1.3 1 1 0 1 1 1 1 Stanniocalcin family ThiC-associated PF13667.1 ESA15820.1 - 0.015 14.8 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 ThiC-associated domain DUF4428 PF14471.1 ESA15820.1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Cpn10 PF00166.16 ESA15820.1 - 0.095 12.6 0.4 0.24 11.3 0.2 1.8 1 1 1 2 2 2 0 Chaperonin 10 Kd subunit Sel1 PF08238.7 ESA15822.1 - 6e-06 26.7 0.6 0.00049 20.6 0.0 2.1 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.1 ESA15822.1 - 0.0085 16.4 0.1 0.018 15.4 0.0 1.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Sel1 PF08238.7 ESA15823.1 - 2.6e-23 81.8 8.4 5.8e-07 29.9 0.2 4.2 4 0 0 4 4 4 3 Sel1 repeat DUF2361 PF10153.4 ESA15823.1 - 0.018 15.2 0.3 0.033 14.3 0.1 1.4 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2361) TPR_6 PF13174.1 ESA15823.1 - 0.059 13.8 2.3 1.9 9.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Jnk-SapK_ap_N PF09744.4 ESA15823.1 - 0.098 12.6 0.3 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TPR_17 PF13431.1 ESA15823.1 - 5.5 7.4 6.1 9.7 6.6 0.3 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA15824.1 - 2.1e-32 112.2 1.6 3.9e-19 68.7 0.0 5.7 6 0 0 6 6 6 4 Protein tyrosine kinase Pkinase PF00069.20 ESA15824.1 - 2.2e-24 86.0 23.5 7.1e-23 81.0 0.3 5.5 5 0 0 5 5 5 2 Protein kinase domain BCS1_N PF08740.6 ESA15824.1 - 4e-07 29.8 6.0 3.3 7.2 0.1 6.6 7 1 1 8 8 8 3 BCS1 N terminal NOB1_Zn_bind PF08772.6 ESA15824.1 - 0.00083 19.1 15.0 1.5 8.7 0.1 5.4 5 0 0 5 5 5 2 Nin one binding (NOB1) Zn-ribbon like DUF4413 PF14372.1 ESA15824.1 - 0.25 11.3 28.2 1.3 9.0 0.3 6.4 6 0 0 6 6 6 0 Domain of unknown function (DUF4413) CENP-F_leu_zip PF10473.4 ESA15824.1 - 0.51 10.2 7.1 2.1 8.1 0.1 4.0 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-DBF PF07535.7 ESA15824.1 - 4.5 7.0 39.8 0.2 11.3 0.6 6.8 5 2 0 5 5 5 0 DBF zinc finger VWA_2 PF13519.1 ESA15826.1 - 7.8e-10 39.1 0.0 1.2e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA15826.1 - 4.8e-07 29.6 0.4 1.1e-06 28.5 0.3 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA15827.1 - 3.5e-08 33.7 0.0 1.3e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 ESA15827.1 - 3e-06 27.0 0.1 6.1e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain SRP54 PF00448.17 ESA15828.1 - 5.2e-19 68.4 0.2 9.8e-19 67.5 0.1 1.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain DJ-1_PfpI PF01965.19 ESA15829.1 - 0.00041 19.8 0.0 0.0008 18.8 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family MreB_Mbl PF06723.8 ESA15829.1 - 0.0015 17.2 0.6 0.027 13.0 0.0 2.1 1 1 1 2 2 2 1 MreB/Mbl protein DUF4325 PF14213.1 ESA15829.1 - 0.011 15.4 1.7 5.7 6.6 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4325) GABP-alpha PF11620.3 ESA15829.1 - 0.041 13.8 0.6 0.083 12.8 0.4 1.5 1 0 0 1 1 1 0 GA-binding protein alpha chain Peptidase_M22 PF00814.20 ESA15829.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycoprotease family GIY-YIG PF01541.19 ESA15831.1 - 5.6e-12 45.8 0.0 1.4e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain T5orf172 PF10544.4 ESA15831.1 - 0.017 15.5 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 T5orf172 domain PBP1_TM PF14812.1 ESA15831.1 - 9 6.6 13.3 30 4.9 9.2 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BTB PF00651.26 ESA15832.1 - 2.4e-12 46.8 0.3 4.7e-12 45.8 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15832.1 - 3.5e-08 33.5 0.1 8.4e-08 32.3 0.1 1.7 1 0 0 1 1 1 1 TLD DUF2018 PF09442.5 ESA15832.1 - 0.12 12.9 2.2 0.19 12.3 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) BTB PF00651.26 ESA15833.1 - 4.7e-19 68.4 0.1 8.5e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA15833.1 - 9.1e-12 45.1 1.5 9.1e-12 45.1 1.0 2.1 2 0 0 2 2 2 1 TLD Ricin_B_lectin PF00652.17 ESA15833.1 - 2.2e-09 37.3 0.0 1e-08 35.2 0.0 2.2 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain BACK PF07707.10 ESA15833.1 - 6.1e-07 29.2 0.9 9.5e-06 25.3 0.0 3.1 3 1 0 3 3 3 1 BTB And C-terminal Kelch RicinB_lectin_2 PF14200.1 ESA15833.1 - 8.5e-06 26.0 0.0 0.0036 17.6 0.0 2.7 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ion_trans PF00520.26 ESA15834.1 - 4.1e-05 22.9 5.1 5.5e-05 22.4 3.5 1.2 1 0 0 1 1 1 1 Ion transport protein DUF1385 PF07136.6 ESA15834.1 - 0.068 12.2 0.2 0.084 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) S4 PF01479.20 ESA15834.1 - 0.17 11.3 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 S4 domain DUF2615 PF11027.3 ESA15834.1 - 0.27 11.1 1.2 0.63 10.0 0.3 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) NmrA PF05368.8 ESA15835.1 - 3.2e-17 62.5 0.1 3.4e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA15835.1 - 6e-08 32.9 0.0 6.7e-08 32.7 0.0 1.0 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA15835.1 - 1.6e-05 23.7 0.1 1.8e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.13 ESA15835.1 - 0.00024 21.0 0.1 0.00028 20.8 0.1 1.1 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.16 ESA15835.1 - 0.0004 19.8 0.0 0.00054 19.4 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 ESA15835.1 - 0.0016 17.4 0.0 0.0018 17.3 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase adh_short PF00106.20 ESA15835.1 - 0.002 18.0 0.0 0.0024 17.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA15835.1 - 0.011 15.3 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 KR domain DapB_N PF01113.15 ESA15835.1 - 0.041 13.8 0.1 0.047 13.6 0.1 1.2 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Herpes_UL6 PF01763.11 ESA15836.1 - 0.0098 14.1 0.3 0.0098 14.1 0.2 1.0 1 0 0 1 1 1 1 Herpesvirus UL6 like Mis12 PF05859.7 ESA15836.1 - 0.022 14.5 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 Mis12 protein GED PF02212.13 ESA15836.1 - 0.048 13.5 0.5 0.06 13.2 0.1 1.4 2 0 0 2 2 2 0 Dynamin GTPase effector domain AstA PF04958.7 ESA15836.1 - 0.12 10.8 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit Pkinase_Tyr PF07714.12 ESA15837.1 - 0.0009 18.3 0.0 0.00094 18.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SpoIISA_toxin PF14171.1 ESA15839.1 - 0.069 12.3 0.2 0.08 12.1 0.1 1.0 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Lamp PF01299.12 ESA15839.1 - 1 8.4 3.7 0.83 8.7 1.7 1.4 1 1 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) SKG6 PF08693.5 ESA15839.1 - 5.2 6.4 8.6 8.6 5.7 6.0 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DNA_mis_repair PF01119.14 ESA15840.1 - 4.8e-11 42.1 0.2 1.3e-10 40.7 0.2 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain PIG-Y PF15159.1 ESA15841.1 - 1e-26 92.9 6.1 1.4e-26 92.5 4.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y ATP-synt_8 PF00895.15 ESA15841.1 - 0.042 14.0 0.1 0.042 14.0 0.1 2.1 2 0 0 2 2 2 0 ATP synthase protein 8 Astacin PF01400.19 ESA15842.1 - 6.7e-22 77.8 0.6 1e-21 77.2 0.4 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) DUF1091 PF06477.8 ESA15842.1 - 0.021 15.2 0.5 0.14 12.5 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1091) Rav1p_C PF12234.3 ESA15843.1 - 3e-175 583.9 3.5 4.4e-175 583.4 2.4 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal BTB PF00651.26 ESA15844.1 - 3.6e-10 39.8 0.1 6.9e-10 38.8 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain VWA PF00092.23 ESA15844.1 - 1.8e-08 34.3 0.3 7.4e-07 29.0 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA15844.1 - 1.5e-06 28.4 0.1 3.3e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain BACK PF07707.10 ESA15845.1 - 0.017 14.9 0.6 0.06 13.1 0.1 1.9 2 0 0 2 2 2 0 BTB And C-terminal Kelch WD40 PF00400.27 ESA15846.1 - 9.2e-19 66.5 16.3 2e-05 24.2 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat CAMSAP_CH PF11971.3 ESA15846.1 - 0.01 15.4 0.1 0.082 12.5 0.0 2.3 2 0 0 2 2 2 0 CAMSAP CH domain Arm PF00514.18 ESA15847.1 - 1e-34 117.1 7.3 5.9e-11 41.7 0.1 5.1 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESA15847.1 - 4.8e-07 29.9 0.0 0.014 15.7 0.0 3.2 1 1 1 2 2 2 2 HEAT repeats V-ATPase_H_C PF11698.3 ESA15847.1 - 8.3e-06 25.7 0.6 0.94 9.4 0.0 3.4 2 1 2 4 4 4 3 V-ATPase subunit H HEAT PF02985.17 ESA15847.1 - 2.4e-05 24.0 0.8 0.32 11.1 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat Arm_2 PF04826.8 ESA15847.1 - 2.8e-05 23.3 5.4 0.00018 20.6 0.7 2.8 1 1 2 3 3 3 2 Armadillo-like Mo25 PF08569.6 ESA15847.1 - 5.2e-05 22.4 2.2 0.00052 19.1 0.1 2.1 1 1 1 2 2 2 1 Mo25-like HEAT_EZ PF13513.1 ESA15847.1 - 0.00019 21.8 0.1 1.8 9.1 0.0 3.2 2 1 1 3 3 3 2 HEAT-like repeat Adaptin_N PF01602.15 ESA15847.1 - 0.00025 19.5 4.7 0.0034 15.7 3.4 2.2 1 1 0 1 1 1 1 Adaptin N terminal region CLASP_N PF12348.3 ESA15847.1 - 0.0084 15.4 3.2 0.011 15.1 1.9 1.4 1 1 0 1 1 1 1 CLASP N terminal CTNNBL PF08216.6 ESA15847.1 - 0.05 13.1 0.2 7.7 6.1 0.0 2.7 3 0 0 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear Proteasom_PSMB PF10508.4 ESA15847.1 - 0.39 8.9 6.0 0.15 10.3 0.7 2.1 1 1 1 2 2 2 0 Proteasome non-ATPase 26S subunit DUF743 PF05332.6 ESA15850.1 - 0.0045 16.9 3.4 0.0099 15.8 2.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF743) Cep57_CLD PF14073.1 ESA15850.1 - 0.014 15.2 4.6 0.014 15.2 3.2 1.9 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 DUF237 PF03072.9 ESA15850.1 - 0.047 13.5 3.6 0.097 12.5 2.5 1.5 1 0 0 1 1 1 0 MG032/MG096/MG288 family 1 Receptor_2B4 PF11465.3 ESA15850.1 - 0.16 11.8 2.0 2.2 8.2 0.3 2.2 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Phage_GP20 PF06810.6 ESA15851.1 - 0.024 14.0 2.4 0.029 13.7 1.7 1.0 1 0 0 1 1 1 0 Phage minor structural protein GP20 CemA PF03040.9 ESA15851.1 - 0.14 11.7 0.7 0.15 11.6 0.5 1.0 1 0 0 1 1 1 0 CemA family ATP-synt_ab PF00006.20 ESA15853.1 - 4.8e-70 235.4 0.0 6.8e-70 234.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 ESA15853.1 - 2.6e-23 82.6 0.0 6.4e-23 81.3 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 ESA15853.1 - 3.9e-20 71.8 1.2 1e-19 70.5 0.8 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 ESA15853.1 - 5.1e-05 23.0 0.7 0.00013 21.8 0.5 1.7 1 0 0 1 1 1 1 HAS barrel domain AAA_25 PF13481.1 ESA15853.1 - 0.085 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain SH3_1 PF00018.23 ESA15854.1 - 1.1e-40 136.7 15.5 5.7e-14 51.2 1.1 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.1 ESA15854.1 - 2.4e-34 116.6 8.3 7.5e-11 41.4 0.3 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.12 ESA15854.1 - 9.3e-25 85.8 2.1 1.6e-09 37.1 0.0 3.9 4 0 0 4 4 4 3 Variant SH3 domain IRS PF02174.12 ESA15854.1 - 0.045 13.3 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 PTB domain (IRS-1 type) SH3_3 PF08239.6 ESA15854.1 - 0.083 13.0 3.8 19 5.5 0.3 3.4 3 0 0 3 3 3 0 Bacterial SH3 domain Selenoprotein_S PF06936.6 ESA15854.1 - 0.75 9.3 9.3 2.2 7.7 6.0 2.1 2 0 0 2 2 2 0 Selenoprotein S (SelS) FBA_3 PF08268.7 ESA15854.1 - 4.7 6.9 6.4 1.1 8.9 0.2 2.7 3 0 0 3 3 3 0 F-box associated domain MCPVI PF02993.9 ESA15854.1 - 9 6.3 9.5 1.4 9.0 2.7 2.2 2 0 0 2 2 2 0 Minor capsid protein VI Hemerythrin PF01814.18 ESA15860.1 - 0.0029 17.7 0.5 0.018 15.2 0.2 2.2 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain IncA PF04156.9 ESA15860.1 - 0.35 10.4 9.7 0.041 13.4 2.9 2.0 2 0 0 2 2 2 0 IncA protein Costars PF14705.1 ESA15862.1 - 0.0042 17.0 0.3 0.012 15.6 0.2 1.8 1 0 0 1 1 1 1 Costars PHB_acc_N PF07879.6 ESA15864.1 - 0.13 12.0 0.5 1.3 8.8 0.2 2.2 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain Orthopox_A43R PF06517.6 ESA15865.1 - 0.024 14.1 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 Orthopoxvirus A43R protein DUF4473 PF14747.1 ESA15865.1 - 0.81 9.9 4.1 0.29 11.3 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) DBINO PF13892.1 ESA15865.1 - 2.2 8.3 9.4 1.8 8.5 3.3 2.1 2 0 0 2 2 2 0 DNA-binding domain YjcZ PF13990.1 ESA15866.1 - 0.15 11.1 0.8 0.48 9.5 0.0 1.8 2 0 0 2 2 2 0 YjcZ-like protein BTB PF00651.26 ESA15867.1 - 1.3e-20 73.4 0.2 1.3e-20 73.4 0.1 2.0 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA15867.1 - 1.9e-08 34.3 7.5 1.9e-08 34.3 5.2 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15867.1 - 1.5e-07 31.1 0.5 1.5e-07 31.1 0.4 2.9 3 1 1 4 4 4 1 BTB And C-terminal Kelch AAA_22 PF13401.1 ESA15869.1 - 0.00011 22.4 0.0 0.002 18.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain DUF4349 PF14257.1 ESA15870.1 - 0.011 15.0 1.7 0.014 14.6 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) NEP PF10167.4 ESA15870.1 - 0.02 14.5 2.1 3.1 7.5 0.5 2.4 2 0 0 2 2 2 0 Uncharacterised conserved protein COG2 PF06148.6 ESA15870.1 - 0.12 12.2 3.8 0.18 11.6 2.6 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 REGB_T4 PF10715.4 ESA15870.1 - 0.15 12.1 3.2 0.18 11.8 0.6 1.9 1 1 1 2 2 2 0 Endoribonuclease RegB T4-bacteriophage encoded DUF573 PF04504.9 ESA15870.1 - 0.2 11.9 5.1 0.068 13.4 1.4 1.8 2 1 0 2 2 2 0 Protein of unknown function, DUF573 Pkinase_Tyr PF07714.12 ESA15871.1 - 2.8e-30 105.2 0.0 4.1e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15871.1 - 8.3e-22 77.5 0.1 1.7e-21 76.5 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain CAF-1_p150 PF11600.3 ESA15872.1 - 0.0081 15.5 13.4 0.011 15.1 9.3 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal APG6 PF04111.7 ESA15872.1 - 1.2 8.1 13.2 1.6 7.7 9.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncFII_repA PF02387.10 ESA15872.1 - 1.9 7.5 9.6 1.8 7.6 6.1 1.4 1 1 0 1 1 1 0 IncFII RepA protein family RCC1_2 PF13540.1 ESA15875.1 - 0.028 14.0 0.2 0.039 13.5 0.2 1.2 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat GMC_oxred_N PF00732.14 ESA15876.1 - 1.1e-37 129.7 0.0 1.5e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ESA15876.1 - 0.00019 20.4 0.1 0.00025 20.0 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 ESA15876.1 - 0.0006 18.8 0.0 0.00089 18.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA15876.1 - 0.0063 16.5 0.0 0.021 14.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DUF1080 PF06439.6 ESA15876.1 - 0.026 14.3 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Thi4 PF01946.12 ESA15876.1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Thi4 family TAP_C PF03943.8 ESA15876.1 - 0.11 11.8 0.3 0.22 10.9 0.2 1.5 1 0 0 1 1 1 0 TAP C-terminal domain NAD_binding_9 PF13454.1 ESA15876.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pkinase PF00069.20 ESA15879.1 - 0.00013 21.2 0.0 0.00016 20.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15879.1 - 0.02 13.9 0.0 0.024 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase ABC1 PF03109.11 ESA15879.1 - 0.06 13.3 0.0 0.13 12.1 0.0 1.6 1 1 1 2 2 2 0 ABC1 family Mating_C PF12737.2 ESA15881.1 - 0.012 14.5 2.5 0.013 14.4 1.7 1.1 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 ATG2_CAD PF13329.1 ESA15881.1 - 0.055 13.0 6.9 0.034 13.7 3.2 1.7 1 1 1 2 2 2 0 Autophagy-related protein 2 CAD motif Birna_VP5 PF03042.9 ESA15881.1 - 0.066 12.7 0.0 0.21 11.1 0.0 1.7 1 1 1 2 2 2 0 Birnavirus VP5 protein PsaA_PsaB PF00223.14 ESA15881.1 - 0.083 10.9 0.2 0.099 10.7 0.1 1.0 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein KapB PF08810.5 ESA15882.1 - 0.015 15.3 0.1 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 Kinase associated protein B zf-NADH-PPase PF09297.6 ESA15882.1 - 0.054 13.0 0.2 0.077 12.5 0.1 1.2 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain DUF1542 PF07564.6 ESA15882.1 - 0.12 12.4 0.5 6.2 6.9 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) TLV_coat PF00429.14 ESA15883.1 - 0.38 9.1 2.1 0.43 8.9 1.4 1.0 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) zf-C2H2_2 PF12756.2 ESA15884.1 - 0.14 12.2 0.2 0.14 12.2 0.1 3.6 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Baculo_E66 PF04850.7 ESA15885.1 - 0.52 9.2 4.3 0.57 9.1 2.9 1.1 1 0 0 1 1 1 0 Baculovirus E66 occlusion-derived virus envelope protein RRM_6 PF14259.1 ESA15886.1 - 0.00028 20.7 0.1 0.0011 18.8 0.0 2.1 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA15886.1 - 0.00064 19.2 0.4 0.18 11.4 0.0 3.2 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4482 PF14818.1 ESA15886.1 - 0.011 16.4 14.1 0.021 15.4 9.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) RRM_5 PF13893.1 ESA15886.1 - 0.032 14.0 0.4 0.4 10.5 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GAGA_bind PF06217.7 ESA15886.1 - 0.23 11.3 10.9 0.35 10.7 7.6 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family APG6 PF04111.7 ESA15886.1 - 8.8 5.2 17.8 15 4.5 12.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 RQC PF09382.5 ESA15887.1 - 0.0031 17.1 0.0 0.005 16.5 0.0 1.4 1 1 0 1 1 1 1 RQC domain TraA PF05513.6 ESA15887.1 - 0.049 13.7 0.1 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 TraA RVT_N PF13655.1 ESA15888.1 - 0.11 12.5 0.9 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase Pkinase_Tyr PF07714.12 ESA15889.1 - 1.5e-20 73.3 0.6 2.3e-17 62.9 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA15889.1 - 1.7e-16 60.1 4.0 1.3e-15 57.2 1.6 2.1 2 0 0 2 2 2 1 Protein kinase domain DUF3488 PF11992.3 ESA15889.1 - 0.025 13.2 0.0 3.8 6.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) Salp15 PF12115.3 ESA15889.1 - 0.056 13.6 6.4 1.4 9.1 1.2 2.4 2 0 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation HSP70 PF00012.15 ESA15890.1 - 2.1e-06 25.9 0.0 1.2e-05 23.4 0.0 2.1 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESA15890.1 - 6.7e-05 21.6 0.0 0.0049 15.5 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Myosin_tail_1 PF01576.14 ESA15891.1 - 0.0015 16.3 19.7 0.0019 16.0 13.7 1.1 1 0 0 1 1 1 1 Myosin tail TPR_MLP1_2 PF07926.7 ESA15891.1 - 0.0038 16.9 20.7 0.0065 16.2 14.3 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein APG6 PF04111.7 ESA15891.1 - 0.0041 16.1 18.1 0.0057 15.7 12.6 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESA15891.1 - 0.014 13.2 8.8 0.017 13.0 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_TATA_bd PF12325.3 ESA15891.1 - 0.046 13.4 22.6 0.053 13.2 4.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Filo_VP35 PF02097.10 ESA15891.1 - 0.071 12.2 0.5 0.094 11.8 0.3 1.5 1 0 0 1 1 1 0 Filoviridae VP35 DUF972 PF06156.8 ESA15891.1 - 0.088 13.1 18.9 1 9.7 1.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) ADIP PF11559.3 ESA15891.1 - 0.3 10.9 22.4 1.6 8.5 7.9 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4200 PF13863.1 ESA15891.1 - 0.35 10.8 21.3 0.46 10.4 11.7 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Mnd1 PF03962.10 ESA15891.1 - 0.43 10.2 15.8 0.81 9.3 10.5 1.7 1 1 0 1 1 1 0 Mnd1 family Phage_GP20 PF06810.6 ESA15891.1 - 0.49 9.8 22.8 0.41 10.0 13.7 2.1 1 1 1 2 2 2 0 Phage minor structural protein GP20 Reo_sigmaC PF04582.7 ESA15891.1 - 0.57 9.3 2.9 1 8.4 0.8 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein bZIP_1 PF00170.16 ESA15891.1 - 0.62 10.0 25.7 1.7 8.6 7.5 3.8 1 1 3 4 4 4 0 bZIP transcription factor DUF2400 PF09674.5 ESA15891.1 - 0.75 9.4 4.8 1 8.9 2.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) PA26 PF04636.8 ESA15891.1 - 0.97 8.0 7.3 1.2 7.7 5.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) IncA PF04156.9 ESA15891.1 - 1.1 8.8 20.7 11 5.5 9.2 2.5 1 1 1 2 2 2 0 IncA protein FTA4 PF13093.1 ESA15891.1 - 1.3 8.4 14.8 6.5 6.1 10.3 2.1 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Tropomyosin_1 PF12718.2 ESA15891.1 - 1.6 8.5 27.0 0.86 9.4 12.0 2.4 1 1 1 2 2 2 0 Tropomyosin like Tox-ODYAM1 PF15642.1 ESA15891.1 - 2.3 6.7 9.8 3.1 6.3 6.8 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Exonuc_VII_L PF02601.10 ESA15891.1 - 3.5 6.7 12.9 4.4 6.3 8.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PRKCSH-like PF12999.2 ESA15891.1 - 3.6 7.1 7.6 5.7 6.4 5.1 1.5 1 1 0 1 1 1 0 Glucosidase II beta subunit-like Spc24 PF08286.6 ESA15891.1 - 3.9 7.1 21.0 5.2 6.8 6.7 2.6 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 CENP-Q PF13094.1 ESA15891.1 - 3.9 7.4 23.9 0.14 12.1 1.5 3.0 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF3552 PF12072.3 ESA15891.1 - 5.3 6.2 22.8 3.9 6.6 14.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Prefoldin PF02996.12 ESA15891.1 - 5.6 6.6 14.8 0.4 10.3 2.3 3.3 2 1 1 3 3 3 0 Prefoldin subunit Syntaxin-6_N PF09177.6 ESA15891.1 - 5.8 7.3 11.5 2.3 8.6 4.6 2.5 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF3571 PF12095.3 ESA15891.1 - 6.6 7.0 9.7 1.1 9.5 3.3 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3571) UPF0231 PF06062.6 ESA15891.1 - 8.2 6.3 9.8 5.9 6.8 5.1 1.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0231) DivIC PF04977.10 ESA15891.1 - 9.3 5.8 23.7 0.11 12.0 5.7 3.7 1 1 2 3 3 3 0 Septum formation initiator DUF4337 PF14235.1 ESA15891.1 - 9.6 6.0 10.5 13 5.5 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) HSP70 PF00012.15 ESA15892.1 - 0.075 10.9 0.0 0.075 10.9 0.0 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF2365 PF10157.4 ESA15893.1 - 2.4e-15 56.6 0.7 2.7e-15 56.5 0.5 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) Spc7 PF08317.6 ESA15893.1 - 0.0074 14.9 1.1 0.0096 14.6 0.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein LPP PF04728.8 ESA15893.1 - 0.019 14.7 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ACDC PF14733.1 ESA15893.1 - 0.069 13.2 0.5 0.1 12.7 0.3 1.4 1 0 0 1 1 1 0 AP2-coincident C-terminal Jnk-SapK_ap_N PF09744.4 ESA15893.1 - 0.074 13.0 0.5 8.6 6.3 0.0 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.5 ESA15893.1 - 0.097 12.7 2.0 0.14 12.2 1.4 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.7 ESA15893.1 - 0.12 12.1 1.9 0.18 11.5 1.3 1.2 1 0 0 1 1 1 0 Laminin Domain II Acylphosphatase PF00708.13 ESA15893.1 - 0.12 12.4 0.2 0.49 10.5 0.0 1.9 1 1 1 2 2 2 0 Acylphosphatase Peptidase_M11 PF05548.6 ESA15894.1 - 0.092 11.6 0.1 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 Gametolysin peptidase M11 FYRC PF05965.9 ESA15897.1 - 0.0021 17.8 0.1 0.052 13.3 0.0 2.4 2 0 0 2 2 2 1 F/Y rich C-terminus DUF2372 PF10178.4 ESA15897.1 - 0.097 12.8 0.0 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2372) LRR_7 PF13504.1 ESA15898.1 - 0.12 12.6 4.8 66 4.3 0.0 5.1 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 ESA15898.1 - 0.47 10.2 8.1 0.39 10.5 2.5 3.1 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 ESA15898.1 - 0.48 10.0 13.8 3 7.5 4.2 3.7 2 2 1 3 3 3 0 Leucine Rich repeats (2 copies) Chordopox_A30L PF06015.7 ESA15898.1 - 3.5 7.2 8.4 0.17 11.5 1.0 2.5 3 0 0 3 3 3 0 Chordopoxvirus A30L protein MACPF PF01823.14 ESA15899.1 - 1.4e-07 31.4 7.2 1.5e-07 31.3 3.9 1.9 1 1 1 2 2 2 1 MAC/Perforin domain Uma2 PF05685.7 ESA15900.1 - 0.012 14.9 0.0 0.059 12.7 0.0 1.9 1 1 0 1 1 1 0 Putative restriction endonuclease UQ_con PF00179.21 ESA15903.1 - 6.8e-43 145.4 0.1 7.6e-43 145.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pet191_N PF10203.4 ESA15904.1 - 5.8e-26 90.3 5.3 6.3e-26 90.2 3.6 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 ESA15904.1 - 4.3 7.1 7.9 5.9 6.7 1.0 2.5 2 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Snf7 PF03357.16 ESA15905.1 - 8.8e-39 132.6 33.3 9.8e-39 132.4 23.1 1.0 1 0 0 1 1 1 1 Snf7 Mitofilin PF09731.4 ESA15905.1 - 0.06 11.9 11.2 0.079 11.6 7.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ist1 PF03398.9 ESA15905.1 - 0.22 10.9 10.6 0.33 10.3 7.3 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF1499 PF07386.6 ESA15905.1 - 0.3 11.2 3.6 1.3 9.2 2.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1499) Phage_Integr_2 PF13009.1 ESA15905.1 - 0.75 8.6 6.7 0.28 10.0 2.8 1.6 1 1 1 2 2 2 0 Putative phage integrase SopA PF13981.1 ESA15905.1 - 1.7 8.7 9.0 0.46 10.4 2.9 2.1 1 1 1 2 2 2 0 SopA-like central domain Sec20 PF03908.8 ESA15905.1 - 3 7.5 11.5 3.9 7.2 2.2 2.4 1 1 0 2 2 2 0 Sec20 PTH2 PF01981.11 ESA15905.1 - 3.2 7.4 9.8 4.3 7.0 1.6 2.3 1 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 V_ATPase_I PF01496.14 ESA15905.1 - 9.3 3.9 12.3 11 3.6 8.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDE_1 PF03184.14 ESA15907.1 - 2.4e-50 170.7 0.2 4e-50 169.9 0.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA15907.1 - 2.8e-07 30.2 0.0 7.3e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA15907.1 - 0.0076 15.9 0.5 0.014 15.1 0.4 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease LBP_BPI_CETP PF01273.20 ESA15907.1 - 0.064 12.5 0.2 0.75 9.1 0.0 2.2 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain Glyco_hydro_88 PF07470.8 ESA15907.1 - 1.3 8.0 4.2 7.1 5.5 0.2 2.8 3 0 0 3 3 3 0 Glycosyl Hydrolase Family 88 Arch_ATPase PF01637.13 ESA15908.1 - 0.00093 18.9 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESA15908.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESA15908.1 - 0.039 14.1 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Tcp11 PF05794.8 ESA15908.1 - 0.061 12.0 0.0 0.074 11.7 0.0 1.2 1 0 0 1 1 1 0 T-complex protein 11 Ldh_2 PF02615.9 ESA15909.1 - 0.035 12.8 0.1 0.044 12.5 0.0 1.0 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase FTA4 PF13093.1 ESA15910.1 - 0.1 12.0 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Striatin PF08232.7 ESA15911.1 - 6.1e-05 23.3 5.8 0.00015 22.0 4.1 1.6 1 1 0 1 1 1 1 Striatin family BCAS2 PF05700.6 ESA15911.1 - 0.00034 20.1 1.5 0.00037 20.0 1.0 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) bZIP_1 PF00170.16 ESA15911.1 - 0.0012 18.7 4.3 0.0015 18.4 3.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor GAS PF13851.1 ESA15911.1 - 0.0042 16.3 4.4 0.0045 16.2 3.1 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DivIC PF04977.10 ESA15911.1 - 0.0052 16.2 5.7 0.012 15.1 3.9 1.7 1 1 0 1 1 1 1 Septum formation initiator BRE1 PF08647.6 ESA15911.1 - 0.0075 16.2 3.4 0.0088 15.9 2.4 1.1 1 0 0 1 1 1 1 BRE1 E3 ubiquitin ligase Ycf1 PF05758.7 ESA15911.1 - 0.014 13.1 2.6 0.013 13.2 1.8 1.0 1 0 0 1 1 1 0 Ycf1 ERM PF00769.14 ESA15911.1 - 0.018 14.5 2.4 0.024 14.1 1.7 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Ax_dynein_light PF10211.4 ESA15911.1 - 0.018 14.8 2.8 0.021 14.6 1.9 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain Phage_GP20 PF06810.6 ESA15911.1 - 0.02 14.3 2.1 0.023 14.1 1.4 1.0 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF724 PF05266.9 ESA15911.1 - 0.024 14.2 1.4 0.024 14.2 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF2730 PF10805.3 ESA15911.1 - 0.024 14.3 0.5 0.032 13.9 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Microtub_assoc PF07989.6 ESA15911.1 - 0.032 14.0 3.0 0.044 13.6 2.1 1.5 1 1 0 1 1 1 0 Microtubule associated V-SNARE PF05008.10 ESA15911.1 - 0.033 14.3 2.8 0.074 13.2 0.4 1.9 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus IncA PF04156.9 ESA15911.1 - 0.036 13.6 1.9 0.039 13.5 1.3 1.0 1 0 0 1 1 1 0 IncA protein Tup_N PF08581.5 ESA15911.1 - 0.041 14.0 1.3 0.045 13.9 0.9 1.1 1 0 0 1 1 1 0 Tup N-terminal DUF2216 PF10226.4 ESA15911.1 - 0.042 13.3 0.7 0.046 13.2 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) DUF972 PF06156.8 ESA15911.1 - 0.042 14.1 1.1 0.046 14.0 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Glypican PF01153.14 ESA15911.1 - 0.053 12.1 0.8 0.059 11.9 0.5 1.0 1 0 0 1 1 1 0 Glypican Mnd1 PF03962.10 ESA15911.1 - 0.056 13.0 3.8 0.065 12.8 2.7 1.0 1 0 0 1 1 1 0 Mnd1 family MbeD_MobD PF04899.7 ESA15911.1 - 0.064 13.1 0.1 0.1 12.5 0.1 1.4 1 1 0 1 1 1 0 MbeD/MobD like DUF4315 PF14193.1 ESA15911.1 - 0.07 13.0 7.5 0.1 12.5 5.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) Shugoshin_N PF07558.6 ESA15911.1 - 0.074 12.7 2.3 0.12 12.1 0.6 2.0 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region TPR_MLP1_2 PF07926.7 ESA15911.1 - 0.085 12.5 2.3 0.11 12.2 1.6 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 ESA15911.1 - 0.093 11.6 3.0 0.093 11.6 2.1 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CASP_C PF08172.7 ESA15911.1 - 0.11 11.5 1.7 0.14 11.1 1.2 1.1 1 0 0 1 1 1 0 CASP C terminal Spc24 PF08286.6 ESA15911.1 - 0.11 12.1 1.3 0.12 12.0 0.9 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 bZIP_2 PF07716.10 ESA15911.1 - 0.12 12.2 4.3 0.27 11.1 3.0 1.8 1 1 0 1 1 1 0 Basic region leucine zipper AAA_13 PF13166.1 ESA15911.1 - 0.12 10.8 2.9 0.12 10.8 2.0 1.0 1 0 0 1 1 1 0 AAA domain CALCOCO1 PF07888.6 ESA15911.1 - 0.12 10.6 2.4 0.24 9.6 1.7 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HalX PF08663.5 ESA15911.1 - 0.14 12.1 1.8 2.4 8.2 0.4 2.1 1 1 1 2 2 2 0 HalX domain Glyco_hydro_101 PF12905.2 ESA15911.1 - 0.14 10.7 2.1 0.15 10.6 1.4 1.0 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase APG6 PF04111.7 ESA15911.1 - 0.15 11.0 2.1 0.15 11.0 1.5 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF904 PF06005.7 ESA15911.1 - 0.16 12.2 3.4 0.21 11.9 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DnaA_N PF11638.3 ESA15911.1 - 0.17 11.4 1.2 0.46 10.1 0.7 1.8 1 1 1 2 2 2 0 DnaA N-terminal domain CCDC-167 PF15188.1 ESA15911.1 - 0.2 11.6 4.3 0.26 11.2 3.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Bap31 PF05529.7 ESA15911.1 - 0.2 11.0 1.2 0.22 10.9 0.8 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Prefoldin PF02996.12 ESA15911.1 - 0.25 10.9 4.4 0.33 10.6 3.0 1.2 1 0 0 1 1 1 0 Prefoldin subunit Syntaxin-6_N PF09177.6 ESA15911.1 - 0.26 11.7 2.9 0.8 10.1 2.0 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal IFRD_C PF04836.7 ESA15911.1 - 0.32 11.1 2.6 0.24 11.6 0.9 1.5 2 0 0 2 2 1 0 Interferon-related protein conserved region TMF_TATA_bd PF12325.3 ESA15911.1 - 0.33 10.6 5.3 1 9.1 3.7 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding TSC22 PF01166.13 ESA15911.1 - 0.38 10.7 4.8 0.7 9.9 0.5 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF4254 PF14063.1 ESA15911.1 - 0.39 10.3 3.9 0.79 9.3 1.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4254) TMF_DNA_bd PF12329.3 ESA15911.1 - 0.73 9.6 7.3 1.5 8.7 5.0 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Cep57_CLD_2 PF14197.1 ESA15911.1 - 0.82 9.6 4.5 1.2 9.1 3.1 1.4 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 Pox_A_type_inc PF04508.7 ESA15911.1 - 2.2 8.2 7.3 17 5.4 1.3 2.8 1 1 0 2 2 2 0 Viral A-type inclusion protein repeat IFP_35_N PF07334.8 ESA15911.1 - 2.6 8.0 5.8 1.7 8.6 0.7 2.0 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus ADH_N PF08240.7 ESA15912.1 - 9e-26 89.7 2.0 1.7e-25 88.8 1.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESA15912.1 - 1.2e-25 89.5 0.0 1.9e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 ESA15912.1 - 0.0011 18.9 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 ESA15912.1 - 0.064 12.4 0.0 0.098 11.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Met_10 PF02475.11 ESA15912.1 - 0.14 11.6 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Baculo_11_kDa PF06143.6 ESA15918.1 - 0.46 9.8 3.1 0.2 11.0 0.4 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family WD40 PF00400.27 ESA15922.1 - 3.8e-06 26.5 0.3 0.0035 17.1 0.1 2.1 2 0 0 2 2 2 2 WD domain, G-beta repeat Multi_ubiq PF14452.1 ESA15923.1 - 0.0033 17.3 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 Multiubiquitin zf-C4pol PF14260.1 ESA15924.1 - 0.063 13.2 3.8 0.11 12.5 2.7 1.5 1 1 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta DUF4495 PF14906.1 ESA15924.1 - 0.075 11.9 1.9 0.088 11.7 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4495) vWF_A PF12450.3 ESA15924.1 - 0.086 12.5 0.1 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor HTH_Tnp_Tc3_1 PF11427.3 ESA15924.1 - 0.14 11.8 0.8 0.25 10.9 0.5 1.4 1 0 0 1 1 1 0 Tc3 transposase MMR_HSR1 PF01926.18 ESA15925.1 - 9.2e-07 28.8 2.4 1.3e-06 28.3 0.2 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA15925.1 - 0.00016 21.6 0.0 0.00067 19.6 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA15925.1 - 0.00046 20.3 0.6 0.026 14.6 0.0 3.1 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA15925.1 - 0.0012 18.0 1.9 0.0018 17.4 0.1 2.3 2 1 0 2 2 2 1 Protein of unknown function, DUF258 AAA PF00004.24 ESA15925.1 - 0.0017 18.5 2.1 0.026 14.7 0.0 3.3 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 ESA15925.1 - 0.0038 16.7 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 ESA15925.1 - 0.0051 17.2 0.8 0.27 11.7 0.0 3.3 2 0 0 2 2 2 1 Miro-like protein UPF0079 PF02367.12 ESA15925.1 - 0.0055 16.3 0.2 0.67 9.6 0.0 2.7 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 ESA15925.1 - 0.0055 16.8 0.9 0.37 10.9 0.0 3.6 3 0 0 3 3 2 1 RNA helicase AAA_17 PF13207.1 ESA15925.1 - 0.0057 17.4 0.2 0.065 14.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 ESA15925.1 - 0.0057 15.5 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.7 ESA15925.1 - 0.012 15.2 0.2 0.13 11.9 0.0 2.7 3 0 0 3 3 3 0 NACHT domain GTP_EFTU PF00009.22 ESA15925.1 - 0.015 14.6 0.5 0.046 13.1 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.22 ESA15925.1 - 0.017 15.3 1.7 0.056 13.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter FtsK_SpoIIIE PF01580.13 ESA15925.1 - 0.028 13.9 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.1 ESA15925.1 - 0.054 13.8 0.1 0.054 13.8 0.0 4.2 3 1 1 4 4 4 0 AAA domain IstB_IS21 PF01695.12 ESA15925.1 - 0.057 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.9 ESA15925.1 - 0.071 12.8 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 ESA15926.1 - 1.3e-08 34.8 0.1 6.1e-08 32.6 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA15926.1 - 2.9e-05 23.3 0.0 0.00013 21.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA15926.1 - 0.0001 21.4 0.0 0.57 9.2 0.0 2.9 2 0 0 2 2 2 2 AIG1 family AAA_29 PF13555.1 ESA15926.1 - 0.00067 19.1 0.0 0.002 17.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ESA15926.1 - 0.011 15.2 0.6 0.033 13.6 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 ESA15926.1 - 0.019 14.9 0.0 0.094 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 ESA15926.1 - 0.021 15.0 0.2 0.39 10.9 0.0 3.0 2 0 0 2 2 2 0 RNA helicase MobB PF03205.9 ESA15926.1 - 0.031 13.9 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 ESA15926.1 - 0.032 13.1 0.0 0.067 12.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 ESA15926.1 - 0.033 14.5 0.0 0.033 14.5 0.0 3.7 4 0 0 4 4 4 0 AAA domain NACHT PF05729.7 ESA15926.1 - 0.047 13.3 0.0 0.62 9.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.13 ESA15926.1 - 0.049 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESA15926.1 - 0.06 13.4 0.0 0.3 11.2 0.0 2.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA15926.1 - 0.15 12.3 0.0 0.15 12.3 0.0 3.1 2 1 0 2 2 1 0 ABC transporter AAA_17 PF13207.1 ESA15926.1 - 0.19 12.5 0.0 0.19 12.5 0.0 3.9 3 2 0 3 3 3 0 AAA domain AAA PF00004.24 ESA15926.1 - 0.25 11.5 2.7 0.45 10.7 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.18 ESA15926.1 - 7.5 6.3 12.5 6.7 6.4 0.0 4.2 3 1 0 3 3 2 0 Dynamin family NAD_binding_6 PF08030.7 ESA15928.1 - 9.4e-35 119.8 0.0 2.6e-34 118.3 0.0 1.8 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 ESA15928.1 - 1.4e-24 85.9 0.0 3.3e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 ESA15928.1 - 3.9e-16 59.2 9.2 3.9e-16 59.2 6.4 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.19 ESA15928.1 - 8.2e-06 25.8 0.0 1.9e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 ESA15928.1 - 0.0076 16.8 0.0 0.4 11.2 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF2975 PF11188.3 ESA15928.1 - 1.4 8.6 8.3 8.8 6.0 5.5 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) Pyr_redox_2 PF07992.9 ESA15929.1 - 4.9e-32 111.4 0.0 1.3e-31 110.1 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.21 ESA15929.1 - 5.8e-17 61.0 0.0 1.7e-16 59.5 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.22 ESA15929.1 - 1.7e-10 41.1 0.3 1.7e-10 41.1 0.2 3.7 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.1 ESA15929.1 - 4.4e-09 36.4 0.0 9e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Reductase C-terminal Pyr_redox_3 PF13738.1 ESA15929.1 - 1.4e-08 35.0 0.0 0.0091 16.0 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.1 ESA15929.1 - 2.9e-07 30.1 0.0 8.2e-07 28.6 0.0 1.8 2 0 0 2 2 1 1 Rieske-like [2Fe-2S] domain DAO PF01266.19 ESA15929.1 - 1.7e-06 27.2 1.2 0.0068 15.3 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.9 ESA15929.1 - 0.00019 20.0 0.3 1.7 7.0 0.1 3.1 3 0 0 3 3 3 3 HI0933-like protein Lycopene_cycl PF05834.7 ESA15929.1 - 0.00051 19.0 0.0 0.76 8.6 0.0 2.8 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_9 PF13454.1 ESA15929.1 - 0.00069 19.4 0.5 13 5.5 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 ESA15929.1 - 0.0024 16.8 2.6 0.013 14.3 0.0 2.8 3 1 0 3 3 3 1 FAD binding domain GIDA PF01134.17 ESA15929.1 - 0.0047 15.8 4.4 2.5 6.8 0.1 3.2 2 1 1 3 3 3 2 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESA15929.1 - 0.017 15.1 0.1 0.061 13.3 0.1 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 ESA15929.1 - 0.08 13.2 0.5 0.82 9.9 0.0 2.6 3 0 0 3 3 3 0 Putative NAD(P)-binding FAD_oxidored PF12831.2 ESA15929.1 - 0.24 10.4 0.5 4.2 6.3 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase MCRS_N PF13325.1 ESA15930.1 - 0.23 10.9 5.7 0.32 10.4 4.0 1.1 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein Fes1 PF08609.5 ESA15931.1 - 0.77 10.2 5.0 1.3 9.5 3.5 1.3 1 0 0 1 1 1 0 Nucleotide exchange factor Fes1 Vpu PF00558.14 ESA15931.1 - 1.7 8.2 5.2 0.95 9.0 1.1 2.0 2 0 0 2 2 2 0 Vpu protein Abhydrolase_3 PF07859.8 ESA15932.1 - 2.9e-05 23.7 0.1 0.0002 21.0 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold NatB_MDM20 PF09797.4 ESA15932.1 - 0.07 11.8 0.4 0.099 11.3 0.3 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Fe_dep_repr_C PF02742.10 ESA15932.1 - 0.11 12.2 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain PHB_depo_C PF06850.6 ESA15933.1 - 0.074 12.2 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 PHB de-polymerase C-terminus Complex1_51K PF01512.12 ESA15933.1 - 0.18 11.5 1.1 0.38 10.4 0.1 2.0 2 1 1 3 3 3 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit DUF4200 PF13863.1 ESA15933.1 - 0.26 11.2 17.0 0.2 11.5 4.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Spectrin PF00435.16 ESA15933.1 - 0.69 10.2 10.4 0.12 12.6 1.3 3.0 3 0 0 3 3 3 0 Spectrin repeat DUF641 PF04859.7 ESA15933.1 - 3.8 7.2 15.4 3 7.6 1.3 3.1 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Sgf11 PF08209.6 ESA15935.1 - 0.055 12.7 1.0 0.055 12.7 0.7 1.9 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Rad1 PF02144.11 ESA15935.1 - 0.079 11.7 0.2 0.1 11.3 0.1 1.1 1 0 0 1 1 1 0 Repair protein Rad1/Rec1/Rad17 Fer4_7 PF12838.2 ESA15935.1 - 0.49 10.8 4.0 0.86 10.0 2.8 1.4 1 0 0 1 1 1 0 4Fe-4S dicluster domain DUF3505 PF12013.3 ESA15935.1 - 0.96 9.7 6.7 0.13 12.5 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3505) zf-C2H2 PF00096.21 ESA15935.1 - 4.2 7.9 8.0 4.4 7.8 2.4 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type p450 PF00067.17 ESA15936.1 - 2e-79 267.3 0.5 2.2e-79 267.1 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyoxal_oxid_N PF07250.6 ESA15937.1 - 5.9e-58 195.7 0.0 4.2e-56 189.7 0.0 3.0 3 1 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.6 ESA15937.1 - 4.9e-14 52.2 1.3 1e-13 51.1 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_4 PF13418.1 ESA15937.1 - 0.00023 20.8 0.5 1 9.1 0.0 3.6 3 1 1 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA15937.1 - 0.0043 16.7 0.0 1.1 9.0 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Nop14 PF04147.7 ESA15938.1 - 0.0058 14.6 18.2 0.0063 14.5 12.6 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2457 PF10446.4 ESA15938.1 - 0.0065 15.2 32.9 0.0075 15.0 22.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CENP-T PF15511.1 ESA15938.1 - 0.011 15.0 9.4 0.011 15.0 6.5 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TFIIA PF03153.8 ESA15938.1 - 0.028 14.3 20.5 0.042 13.7 14.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.9 ESA15938.1 - 0.052 11.5 13.4 0.062 11.3 9.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 ESA15938.1 - 0.37 10.1 8.5 0.49 9.7 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PPP4R2 PF09184.6 ESA15938.1 - 0.5 9.8 19.6 0.72 9.3 13.6 1.3 1 0 0 1 1 1 0 PPP4R2 FimP PF09766.4 ESA15938.1 - 1.2 8.1 3.7 1.6 7.7 2.5 1.1 1 0 0 1 1 1 0 Fms-interacting protein Astro_capsid PF03115.9 ESA15938.1 - 1.3 7.1 9.0 1.5 7.0 6.2 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor BUD22 PF09073.5 ESA15938.1 - 2.4 7.1 14.1 2.8 6.9 9.8 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.7 ESA15938.1 - 5.4 6.1 23.2 7.2 5.7 16.1 1.1 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.7 ESA15938.1 - 6.6 5.9 21.5 7.7 5.7 14.9 1.1 1 0 0 1 1 1 0 SDA1 TLD PF07534.11 ESA15939.1 - 1.9e-06 27.9 0.2 2e-06 27.8 0.2 1.0 1 0 0 1 1 1 1 TLD PDZ_2 PF13180.1 ESA15943.1 - 1e-10 41.3 3.0 2.8e-06 27.1 0.1 3.2 3 0 0 3 3 3 2 PDZ domain PDZ_1 PF12812.2 ESA15943.1 - 2.2e-07 30.6 0.0 9.3e-07 28.6 0.0 2.0 2 0 0 2 2 2 1 PDZ-like domain PDZ PF00595.19 ESA15943.1 - 1.9e-05 24.7 0.3 0.021 14.9 0.1 3.2 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) Big_5 PF13205.1 ESA15944.1 - 1.2e-05 25.8 1.2 2.6e-05 24.7 0.8 1.6 1 0 0 1 1 1 1 Bacterial Ig-like domain Mrr_cat PF04471.7 ESA15949.1 - 0.0019 17.9 0.1 0.0045 16.7 0.0 1.6 2 0 0 2 2 2 1 Restriction endonuclease DUF3647 PF12363.3 ESA15951.1 - 0.0012 18.9 2.0 0.0014 18.6 1.4 1.2 1 0 0 1 1 1 1 Phage protein DUF1493 PF07377.7 ESA15951.1 - 0.043 13.9 0.9 0.049 13.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) DDE_1 PF03184.14 ESA15952.1 - 5.3e-06 25.7 0.1 5.8e-06 25.6 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease SieB PF14163.1 ESA15954.1 - 6.3e-05 22.5 0.4 0.00013 21.5 0.3 1.6 1 0 0 1 1 1 1 Superinfection exclusion protein B CAGE1 PF15066.1 ESA15954.1 - 0.052 11.9 2.4 0.077 11.4 1.7 1.2 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family AAA_26 PF13500.1 ESA15954.1 - 0.078 12.5 0.0 0.49 9.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain Ribosomal_L37ae PF01780.14 ESA15955.1 - 0.032 14.0 0.5 0.074 12.9 0.3 1.6 1 0 0 1 1 1 0 Ribosomal L37ae protein family DAOA PF15199.1 ESA15955.1 - 0.047 14.3 0.7 0.096 13.3 0.5 1.6 1 0 0 1 1 1 0 D-amino acid oxidase activator zinc-ribbons_6 PF07191.7 ESA15955.1 - 0.21 11.3 3.8 0.38 10.5 2.6 1.3 1 0 0 1 1 1 0 zinc-ribbons zf-C3HC4_2 PF13923.1 ESA15955.1 - 1 9.4 5.6 5.1 7.2 3.9 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 ESA15957.1 - 3.3e-29 101.8 0.3 5.4e-29 101.1 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA15957.1 - 1.9e-28 99.2 0.0 2.8e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Spore_III_AB PF09548.5 ESA15957.1 - 0.039 13.6 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3753 PF12575.3 ESA15957.1 - 0.076 12.8 0.6 1.2 8.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3753) Pyocin_S PF06958.7 ESA15958.1 - 0.09 13.1 0.5 1e+02 3.2 0.0 4.2 5 0 0 5 5 5 0 S-type Pyocin DUF3072 PF11272.3 ESA15958.1 - 0.2 11.3 0.0 4.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) HypA PF01155.14 ESA15958.1 - 8.2 6.1 15.1 11 5.7 0.2 4.7 5 0 0 5 5 5 0 Hydrogenase expression/synthesis hypA family DUF3500 PF12006.3 ESA15960.1 - 0.031 13.2 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) zf-CCCH PF00642.19 ESA15961.1 - 2.6e-17 62.0 13.4 9.1e-09 34.8 0.9 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESA15961.1 - 5.1e-06 26.2 16.6 0.0025 17.7 1.6 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type SspO PF08175.7 ESA15961.1 - 0.08 13.2 6.1 1.1 9.5 2.6 2.4 2 0 0 2 2 2 0 Small acid-soluble spore protein O family zf-C3H1 PF10650.4 ESA15961.1 - 8.1 6.0 8.9 12 5.5 0.7 3.1 2 2 0 2 2 2 0 Putative zinc-finger domain Ran-binding PF05508.6 ESA15962.1 - 1.7e-71 240.5 11.1 7.7e-71 238.4 4.4 2.5 1 1 1 2 2 2 2 RanGTP-binding protein PNRC PF15365.1 ESA15962.1 - 0.0033 17.3 0.2 0.022 14.7 0.2 2.5 1 0 0 1 1 1 1 Proline-rich nuclear receptor coactivator 2OG-FeII_Oxy_2 PF13532.1 ESA15963.1 - 8.2e-24 84.5 0.0 1.5e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.7 ESA15963.1 - 2.5e-10 40.1 1.1 7.4e-10 38.6 0.7 1.9 1 0 0 1 1 1 1 GRF zinc finger NPFF PF15085.1 ESA15963.1 - 0.044 14.0 7.3 0.34 11.2 1.7 3.0 3 1 0 3 3 3 0 Neuropeptide FF ADH_zinc_N PF00107.21 ESA15964.1 - 3.3e-30 104.2 0.0 7.6e-30 103.1 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA15964.1 - 1.7e-16 61.2 0.0 3.3e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA15964.1 - 2.5e-11 43.2 1.1 1.1e-10 41.2 0.2 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.13 ESA15964.1 - 0.019 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain WD40 PF00400.27 ESA15965.1 - 5.8e-13 48.1 15.8 1.4e-05 24.7 0.6 5.8 6 1 0 6 6 6 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 ESA15965.1 - 0.00092 18.9 0.0 1.6 8.5 0.0 2.7 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.6 ESA15965.1 - 0.0027 17.4 0.0 2.8 7.5 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.1 ESA15965.1 - 0.041 13.3 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 0 PQQ-like domain UCR_UQCRX_QCR9 PF05365.7 ESA15966.1 - 4.5e-30 103.0 2.2 5.3e-30 102.8 1.5 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Tricorn_C1 PF14684.1 ESA15966.1 - 0.075 12.9 1.3 0.12 12.2 0.9 1.3 1 0 0 1 1 1 0 Tricorn protease C1 domain SAP18 PF06487.7 ESA15967.1 - 8.1e-41 138.6 0.2 1.2e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) DUF4203 PF13886.1 ESA15969.1 - 5.6e-15 55.3 27.5 7.3e-15 54.9 19.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Kelch_6 PF13964.1 ESA15971.1 - 3.7e-25 86.9 17.1 2.9e-07 30.3 0.3 6.2 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.1 ESA15971.1 - 4.1e-25 87.2 18.0 8.6e-10 38.2 0.1 6.3 6 2 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA15971.1 - 1.7e-22 78.9 13.8 1.8e-06 27.7 0.1 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.1 ESA15971.1 - 7.9e-20 70.4 11.7 3.4e-08 33.4 0.0 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA15971.1 - 1.5e-15 56.4 16.2 0.00074 19.0 0.3 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.10 ESA15971.1 - 1.8e-14 52.8 6.8 0.0005 19.7 0.0 5.3 6 0 0 6 6 6 4 Kelch motif YjgP_YjgQ PF03739.9 ESA15971.1 - 0.0075 15.0 0.1 0.031 13.0 0.1 1.9 2 1 0 2 2 2 1 Predicted permease YjgP/YjgQ family DUF2080 PF09853.4 ESA15972.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative transposon-encoded protein (DUF2080) Aminotran_5 PF00266.14 ESA15973.1 - 1.1e-07 30.9 0.0 1.4e-07 30.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V PG_binding_2 PF08823.6 ESA15973.1 - 0.12 12.4 0.0 5.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Putative peptidoglycan binding domain HMG_box PF00505.14 ESA15974.1 - 1.5e-05 25.1 0.0 3.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Laminin_N PF00055.12 ESA15974.1 - 0.089 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Laminin N-terminal (Domain VI) Citrate_synt PF00285.16 ESA15975.1 - 4.4e-128 426.9 0.0 5.8e-128 426.5 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase E1_DerP2_DerF2 PF02221.10 ESA15976.1 - 3.6e-05 24.0 0.1 4.7e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 ML domain GDI PF00996.13 ESA15977.1 - 4.4e-124 414.1 0.1 6.6e-124 413.5 0.0 1.2 1 1 0 1 1 1 1 GDP dissociation inhibitor Pkinase_Tyr PF07714.12 ESA15978.1 - 6.7e-48 163.0 0.0 9.4e-48 162.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15978.1 - 3.7e-40 137.7 0.0 6.3e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF1509 PF07420.6 ESA15978.1 - 1.1 8.4 7.1 1.7 7.8 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Pkinase_Tyr PF07714.12 ESA15979.1 - 4.1e-36 124.3 0.8 7.2e-36 123.5 0.5 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15979.1 - 7.5e-26 90.8 0.9 1.7e-25 89.6 0.6 1.5 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA15979.1 - 2.4e-11 43.8 2.9 0.002 18.7 0.0 3.5 3 0 0 3 3 3 3 Sel1 repeat Pkinase_Tyr PF07714.12 ESA15980.1 - 6.2e-47 159.8 0.0 8.7e-47 159.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA15980.1 - 3.8e-42 144.2 0.1 6.5e-42 143.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain AAA_22 PF13401.1 ESA15981.1 - 3.1e-06 27.3 0.0 6.7e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA15981.1 - 0.00027 20.7 0.2 0.00074 19.2 0.1 1.8 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA15981.1 - 0.004 17.1 0.0 0.031 14.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 ESA15981.1 - 0.0056 16.5 5.8 0.0089 15.9 0.1 3.5 3 1 0 3 3 3 1 AAA domain SieB PF14163.1 ESA15981.1 - 0.032 13.7 0.0 0.071 12.6 0.0 1.5 1 0 0 1 1 1 0 Superinfection exclusion protein B AAA_25 PF13481.1 ESA15981.1 - 0.048 13.0 0.1 3 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain Uma2 PF05685.7 ESA15983.1 - 0.078 12.3 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Putative restriction endonuclease DUF1751 PF08551.5 ESA15984.1 - 1.5e-25 89.4 0.5 1.5e-25 89.4 0.3 2.2 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.17 ESA15984.1 - 0.002 18.1 7.9 0.0042 17.1 5.5 1.6 1 1 0 1 1 1 1 Rhomboid family HR_lesion PF05514.6 ESA15984.1 - 0.022 14.5 1.1 0.022 14.5 0.8 2.0 1 1 1 2 2 2 0 HR-like lesion-inducing Birna_RdRp PF04197.7 ESA15985.1 - 0.078 11.0 0.4 0.08 10.9 0.3 1.0 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) AAA-ATPase_like PF09820.4 ESA15986.1 - 8.8e-06 25.0 0.5 0.016 14.3 0.1 2.1 1 1 1 2 2 2 2 Predicted AAA-ATPase Actin PF00022.14 ESA15987.1 - 1.1e-104 349.9 0.0 1.3e-104 349.7 0.0 1.0 1 0 0 1 1 1 1 Actin Uma2 PF05685.7 ESA15988.1 - 9.9e-07 28.2 0.0 1.1e-06 28.1 0.0 1.0 1 0 0 1 1 1 1 Putative restriction endonuclease Omp28 PF11551.3 ESA15988.1 - 0.11 12.0 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein Omp28 DDE_3 PF13358.1 ESA15991.1 - 4.1e-07 29.8 0.1 5.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Nop14 PF04147.7 ESA15992.1 - 1.1 7.0 29.6 1.4 6.7 20.5 1.1 1 0 0 1 1 1 0 Nop14-like family AA_permease PF00324.16 ESA15993.1 - 0.043 12.1 0.0 0.049 11.9 0.0 1.0 1 0 0 1 1 1 0 Amino acid permease SpoIIIAH PF12685.2 ESA15993.1 - 0.057 12.8 0.4 0.068 12.6 0.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF1510 PF07423.6 ESA15993.1 - 0.068 12.5 1.8 0.084 12.2 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Fic PF02661.13 ESA15994.1 - 4.2e-16 59.4 0.0 9.8e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 Fic/DOC family Eaf7 PF07904.8 ESA15994.1 - 0.0051 16.7 0.4 0.013 15.4 0.2 1.8 1 1 0 1 1 1 1 Chromatin modification-related protein EAF7 UCR_UQCRX_QCR9 PF05365.7 ESA15994.1 - 0.03 13.9 1.1 0.24 11.0 0.2 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like HPD PF05044.7 ESA15994.1 - 0.12 12.0 3.2 10 5.7 0.1 3.5 2 1 1 4 4 4 0 Homeo-prospero domain TLD PF07534.11 ESA15996.1 - 3.5e-12 46.4 0.6 3.5e-12 46.4 0.4 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA15996.1 - 4.5e-07 29.6 0.3 1.3e-06 28.1 0.2 1.9 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF1986 PF09342.6 ESA15996.1 - 0.011 14.9 0.7 3 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) SAM_2 PF07647.12 ESA15997.1 - 0.034 14.0 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF3109 PF11307.3 ESA15997.1 - 0.051 13.0 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3109) SAM_1 PF00536.25 ESA15997.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF1823 PF08853.6 ESA15998.1 - 0.036 13.7 0.3 0.99 9.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1823) TLD PF07534.11 ESA15999.1 - 2.1e-11 43.9 0.7 6.5e-11 42.3 0.5 1.9 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA15999.1 - 2.7e-10 40.2 0.0 5.9e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA15999.1 - 0.0068 16.2 0.4 0.23 11.3 0.0 3.3 3 1 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA16000.1 - 1.4e-20 73.3 0.3 5.3e-20 71.4 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA16000.1 - 3e-13 49.9 2.1 6.9e-13 48.7 1.5 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16000.1 - 0.0079 16.0 1.4 0.035 13.9 0.0 2.8 3 1 0 3 3 3 1 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA16000.1 - 0.24 11.4 2.2 6.5 6.9 0.0 3.3 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain TLD PF07534.11 ESA16001.1 - 7e-13 48.7 3.9 1.6e-12 47.5 2.7 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA16001.1 - 5.6e-11 42.4 1.0 1.8e-10 40.8 0.7 1.9 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA16002.1 - 1.2e-11 44.5 0.0 1.5e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16003.1 - 3.3e-06 27.1 3.0 5.6e-06 26.4 2.1 1.5 1 0 0 1 1 1 1 TLD TLD PF07534.11 ESA16004.1 - 2.1e-10 40.7 0.2 4.9e-10 39.5 0.1 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA16004.1 - 0.0018 18.2 1.0 0.0037 17.2 0.4 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA16004.1 - 0.052 13.3 0.2 0.26 11.1 0.0 2.3 1 1 1 2 2 2 0 BTB And C-terminal Kelch ALO PF04030.9 ESA16007.1 - 3.2e-10 40.0 2.9 1.1e-09 38.2 2.0 1.8 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESA16007.1 - 1.2e-06 28.0 0.0 2.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FF PF01846.14 ESA16007.1 - 0.082 12.8 2.0 5.6 6.9 0.1 3.0 3 0 0 3 3 3 0 FF domain AMP-binding PF00501.23 ESA16009.1 - 3.9e-97 325.2 0.0 4.7e-97 325.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESA16009.1 - 8.1e-14 52.3 0.4 3.9e-13 50.1 0.1 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF826 PF05696.6 ESA16012.1 - 0.026 14.6 1.3 0.042 13.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF826) CTD_bind PF04818.8 ESA16012.1 - 0.049 13.8 1.6 0.071 13.3 1.1 1.2 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Herpes_UL92 PF03048.9 ESA16012.1 - 0.059 12.9 0.3 0.062 12.8 0.2 1.0 1 0 0 1 1 1 0 UL92 family MreB_Mbl PF06723.8 ESA16012.1 - 0.068 11.7 1.0 0.073 11.6 0.7 1.0 1 0 0 1 1 1 0 MreB/Mbl protein Sel1 PF08238.7 ESA16013.1 - 2.2e-25 88.5 0.8 4.6e-07 30.2 0.0 3.2 3 0 0 3 3 3 3 Sel1 repeat TPR_17 PF13431.1 ESA16013.1 - 0.0012 18.9 0.3 3.5 8.0 0.1 3.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16013.1 - 0.0056 17.0 3.1 1.9 9.0 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat Colicin_immun PF09204.5 ESA16013.1 - 0.03 14.3 0.2 1 9.4 0.0 2.1 1 1 1 2 2 2 0 Bacterial self-protective colicin-like immunity PARG_cat PF05028.9 ESA16022.1 - 4e-10 39.4 0.0 1.4e-09 37.7 0.0 1.7 2 0 0 2 2 2 1 Poly (ADP-ribose) glycohydrolase (PARG) CAT PF00302.13 ESA16023.1 - 0.033 13.7 0.1 0.04 13.5 0.1 1.1 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase Lactate_perm PF02652.9 ESA16025.1 - 0.089 11.2 0.1 0.089 11.2 0.0 1.0 1 0 0 1 1 1 0 L-lactate permease Prenylcys_lyase PF07156.9 ESA16026.1 - 0.018 13.9 0.2 0.021 13.7 0.1 1.2 1 0 0 1 1 1 0 Prenylcysteine lyase LRR_6 PF13516.1 ESA16026.1 - 5.2 7.4 6.2 23 5.4 0.6 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Colicin_D PF11429.3 ESA16027.1 - 0.05 13.7 0.1 0.14 12.3 0.1 1.8 1 0 0 1 1 1 0 Colicin D COX5A PF02284.11 ESA16028.1 - 3.4e-41 139.5 0.1 4.3e-41 139.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va LRR_6 PF13516.1 ESA16033.1 - 0.2 11.8 3.3 32 5.0 0.0 4.0 2 0 0 2 2 2 0 Leucine Rich repeat Myb_DNA-bind_6 PF13921.1 ESA16034.1 - 0.0065 16.5 4.0 0.011 15.8 0.1 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain CENP-B_dimeris PF09026.5 ESA16035.1 - 0.027 14.7 2.4 0.029 14.5 1.6 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sel1 PF08238.7 ESA16037.1 - 6.2e-123 398.5 47.1 2.3e-12 47.1 0.3 11.6 12 0 0 12 12 12 11 Sel1 repeat TPR_6 PF13174.1 ESA16037.1 - 5.4e-08 32.7 22.3 0.53 10.8 0.0 9.7 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_11 PF13414.1 ESA16037.1 - 0.015 14.9 51.4 0.033 13.8 1.0 8.3 2 1 5 8 8 8 0 TPR repeat TPR_12 PF13424.1 ESA16037.1 - 1 9.3 32.7 2.8 7.9 1.4 8.1 5 2 5 10 10 10 0 Tetratricopeptide repeat MIT PF04212.13 ESA16037.1 - 2.4 8.0 41.7 7.5 6.5 0.4 9.3 7 2 2 9 9 9 0 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.12 ESA16040.1 - 0.0002 20.5 0.1 0.00025 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase GXWXG PF14231.1 ESA16041.1 - 0.031 13.9 0.1 0.065 12.8 0.1 1.5 1 1 0 1 1 1 0 GXWXG protein Oxidored_q2 PF00420.19 ESA16042.1 - 0.0021 17.6 2.7 0.0039 16.7 1.9 1.4 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Ion_trans PF00520.26 ESA16042.1 - 0.079 12.1 13.2 0.11 11.7 9.2 1.2 1 0 0 1 1 1 0 Ion transport protein zf-DBF PF07535.7 ESA16043.1 - 0.0033 17.0 0.3 0.008 15.8 0.2 1.6 1 0 0 1 1 1 1 DBF zinc finger NusA_N PF08529.6 ESA16043.1 - 0.056 13.4 0.2 4.2 7.3 0.0 2.4 2 0 0 2 2 2 0 NusA N-terminal domain zf-C2H2_jaz PF12171.3 ESA16043.1 - 0.41 10.8 3.2 2.1 8.6 2.2 2.1 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding SCO1-SenC PF02630.9 ESA16048.1 - 0.048 13.2 2.2 0.5 9.9 0.3 2.2 2 0 0 2 2 2 0 SCO1/SenC Ldh_2 PF02615.9 ESA16048.1 - 0.26 9.9 1.2 1.6 7.4 0.1 2.0 2 0 0 2 2 2 0 Malate/L-lactate dehydrogenase Alpha_L_fucos PF01120.12 ESA16049.1 - 0.11 11.4 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Alpha-L-fucosidase HPD PF05044.7 ESA16050.1 - 0.01 15.5 3.0 0.19 11.4 1.4 2.0 1 1 1 2 2 2 0 Homeo-prospero domain LRR_5 PF13306.1 ESA16050.1 - 0.027 14.1 0.9 0.033 13.9 0.6 1.3 1 1 0 1 1 1 0 Leucine rich repeats (6 copies) IBD PF10416.4 ESA16050.1 - 0.036 13.8 0.9 0.043 13.6 0.6 1.2 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD TcdB_N PF12918.2 ESA16050.1 - 0.037 14.0 0.7 0.037 14.0 0.5 1.5 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain RFC1 PF08519.7 ESA16050.1 - 0.16 11.7 1.5 0.28 10.9 0.9 1.5 1 1 1 2 2 2 0 Replication factor RFC1 C terminal domain Eaf7 PF07904.8 ESA16050.1 - 1.8 8.5 4.8 3.3 7.7 3.3 1.4 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 C2 PF00168.25 ESA16051.1 - 1e-15 57.3 0.2 1.5e-15 56.7 0.1 1.3 1 0 0 1 1 1 1 C2 domain Mito_carr PF00153.22 ESA16052.1 - 2.9e-70 232.0 4.0 2.9e-23 81.3 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Miro PF08477.8 ESA16053.1 - 3.8e-38 130.6 0.0 6.2e-21 75.1 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein EF_assoc_2 PF08356.7 ESA16053.1 - 3e-35 119.8 0.0 6.3e-35 118.8 0.0 1.6 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.7 ESA16053.1 - 1.8e-31 107.2 0.6 3.5e-31 106.2 0.4 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.17 ESA16053.1 - 1.2e-28 99.5 0.0 7.3e-21 74.2 0.0 2.2 2 0 0 2 2 2 2 Ras family Arf PF00025.16 ESA16053.1 - 2.1e-10 40.1 0.0 1.1e-05 24.7 0.0 2.4 2 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA16053.1 - 6e-10 39.0 0.1 0.00029 20.7 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_22 PF13401.1 ESA16053.1 - 6.5e-10 39.2 0.0 0.00021 21.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain EF-hand_1 PF00036.27 ESA16053.1 - 1.4e-09 36.5 3.5 0.0006 18.9 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 ESA16053.1 - 1.3e-08 33.9 1.8 0.0029 17.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain SRPRB PF09439.5 ESA16053.1 - 1.6e-08 33.9 0.1 0.00078 18.7 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit MobB PF03205.9 ESA16053.1 - 1.8e-07 30.9 0.0 0.0079 15.9 0.0 2.4 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B EF-hand_7 PF13499.1 ESA16053.1 - 2e-07 31.0 0.4 0.0094 16.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Dynamin_N PF00350.18 ESA16053.1 - 4.3e-07 29.9 0.0 0.0014 18.4 0.0 2.7 2 0 0 2 2 2 2 Dynamin family EF-hand_5 PF13202.1 ESA16053.1 - 5.1e-06 25.5 5.5 0.027 13.8 0.8 2.6 2 0 0 2 2 2 2 EF hand ABC_tran PF00005.22 ESA16053.1 - 8e-06 26.1 0.0 0.06 13.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_18 PF13238.1 ESA16053.1 - 1e-05 25.8 0.0 0.041 14.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 ESA16053.1 - 1.1e-05 25.4 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.7 ESA16053.1 - 1.3e-05 24.9 0.0 0.2 11.3 0.0 2.7 2 1 0 2 2 2 2 NACHT domain EF-hand_8 PF13833.1 ESA16053.1 - 1.7e-05 24.3 2.8 0.015 14.8 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair AAA_29 PF13555.1 ESA16053.1 - 1.9e-05 24.1 0.0 0.04 13.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_24 PF13479.1 ESA16053.1 - 2.2e-05 24.1 0.1 0.18 11.3 0.0 2.6 3 0 0 3 3 2 2 AAA domain AAA PF00004.24 ESA16053.1 - 4.5e-05 23.6 0.0 0.36 11.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Septin PF00735.13 ESA16053.1 - 4.9e-05 22.4 0.2 0.014 14.4 0.1 3.0 2 1 1 3 3 3 1 Septin Arch_ATPase PF01637.13 ESA16053.1 - 9.5e-05 22.1 0.0 0.024 14.3 0.0 2.3 2 0 0 2 2 2 1 Archaeal ATPase AAA_33 PF13671.1 ESA16053.1 - 0.00019 21.2 0.0 0.24 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA16053.1 - 0.00023 20.3 0.0 0.031 13.4 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Viral_helicase1 PF01443.13 ESA16053.1 - 0.00044 19.8 0.0 0.15 11.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.1 ESA16053.1 - 0.00045 20.2 0.0 1.1 9.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.8 ESA16053.1 - 0.00046 19.1 0.0 0.31 9.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF815) EF-hand_10 PF14788.1 ESA16053.1 - 0.00059 19.4 3.1 0.029 14.0 0.1 2.5 2 0 0 2 2 2 1 EF hand RNA_helicase PF00910.17 ESA16053.1 - 0.00061 19.9 0.0 0.46 10.6 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.9 ESA16053.1 - 0.00068 19.3 0.0 0.0072 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) G-alpha PF00503.15 ESA16053.1 - 0.00071 18.3 0.0 1.4 7.5 0.0 3.1 3 0 0 3 3 3 1 G-protein alpha subunit NB-ARC PF00931.17 ESA16053.1 - 0.00083 18.2 0.0 0.86 8.4 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AIG1 PF04548.11 ESA16053.1 - 0.00091 18.3 0.7 0.0027 16.8 0.1 1.9 2 0 0 2 2 2 1 AIG1 family ATP_bind_1 PF03029.12 ESA16053.1 - 0.0017 17.9 1.3 1.9 7.9 0.1 3.3 2 1 1 3 3 3 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.7 ESA16053.1 - 0.003 16.7 0.0 1.7 7.7 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_17 PF13207.1 ESA16053.1 - 0.0065 17.2 0.0 2.8 8.7 0.0 3.1 3 0 0 3 3 2 0 AAA domain Pox_A32 PF04665.7 ESA16053.1 - 0.0097 15.2 0.0 3.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein GTP_EFTU PF00009.22 ESA16053.1 - 0.01 15.3 0.5 1.3 8.3 0.0 3.1 3 1 0 4 4 4 1 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 ESA16053.1 - 0.012 15.0 0.0 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain AAA_25 PF13481.1 ESA16053.1 - 0.017 14.5 0.0 0.94 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA16053.1 - 0.02 14.3 0.1 11 5.5 0.0 3.1 4 0 0 4 4 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 ESA16053.1 - 0.025 14.4 0.0 8.7 6.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 ESA16053.1 - 0.026 14.4 0.0 4.1 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA16053.1 - 0.037 13.4 0.0 8.6 5.7 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_23 PF13476.1 ESA16053.1 - 0.037 14.3 0.3 6 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 ESA16053.1 - 0.04 13.3 3.9 2 7.8 0.0 3.5 3 1 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.7 ESA16053.1 - 0.052 12.6 0.0 9.6 5.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.1 ESA16053.1 - 0.062 13.0 0.0 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain T2SE PF00437.15 ESA16053.1 - 0.082 11.7 0.1 6.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SRP54 PF00448.17 ESA16053.1 - 0.092 12.1 0.1 7.6 5.9 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain SPARC_Ca_bdg PF10591.4 ESA16053.1 - 0.11 12.4 2.5 5.7 7.0 0.0 3.4 3 1 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region TrwB_AAD_bind PF10412.4 ESA16053.1 - 0.13 10.8 0.0 6.3 5.3 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.1 ESA16053.1 - 0.14 11.7 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain MCM PF00493.18 ESA16053.1 - 0.16 10.7 0.0 0.46 9.2 0.0 1.8 2 0 0 2 2 2 0 MCM2/3/5 family AAA_32 PF13654.1 ESA16053.1 - 0.2 10.2 0.0 2.3 6.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain VHS PF00790.14 ESA16054.1 - 1e-31 109.4 0.7 2.5e-31 108.1 0.5 1.7 1 0 0 1 1 1 1 VHS domain SH3_9 PF14604.1 ESA16054.1 - 1.4e-17 63.0 0.8 3.4e-17 61.7 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 ESA16054.1 - 1.5e-16 59.5 0.0 4.5e-16 57.9 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA16054.1 - 3.5e-12 45.5 0.3 9.2e-12 44.2 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain GAT PF03127.9 ESA16054.1 - 1.9e-06 27.7 0.2 1.9e-06 27.7 0.2 4.2 4 1 1 5 5 5 1 GAT domain DUF3221 PF11518.3 ESA16058.1 - 0.03 13.9 0.5 0.045 13.4 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3221) Nefa_Nip30_N PF10187.4 ESA16059.1 - 0.066 13.3 0.5 0.087 13.0 0.4 1.2 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 LRR_4 PF12799.2 ESA16060.1 - 0.00017 21.0 1.5 0.00017 21.0 1.0 3.8 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA16060.1 - 0.026 14.2 1.3 0.026 14.2 0.9 2.4 2 0 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.1 ESA16060.1 - 0.063 13.3 2.5 2.5 8.4 0.4 3.8 2 1 1 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.28 ESA16060.1 - 0.14 12.2 4.9 23 5.5 0.0 4.8 4 0 0 4 4 4 0 Leucine Rich Repeat ATG16 PF08614.6 ESA16060.1 - 0.22 11.3 81.0 0.038 13.8 16.8 4.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) MCPsignal PF00015.16 ESA16060.1 - 0.59 9.6 14.2 1.8 8.0 0.6 2.9 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Spc7 PF08317.6 ESA16060.1 - 8 5.0 75.8 5 5.6 17.1 3.3 1 1 3 4 4 4 0 Spc7 kinetochore protein MULE PF10551.4 ESA16061.1 - 2.8e-06 27.4 0.0 4.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain L71 PF02448.10 ESA16061.1 - 0.082 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 L71 family HGTP_anticodon2 PF12745.2 ESA16063.1 - 0.026 13.6 0.0 0.051 12.7 0.1 1.3 2 0 0 2 2 2 0 Anticodon binding domain of tRNAs CCDC14 PF15254.1 ESA16063.1 - 0.34 9.2 4.3 0.42 8.9 3.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 HMG_box PF00505.14 ESA16066.1 - 0.00034 20.8 1.6 0.00092 19.4 1.1 1.7 1 1 0 1 1 1 1 HMG (high mobility group) box DUF3965 PF13112.1 ESA16066.1 - 0.014 14.5 0.8 0.022 13.9 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) HMG_box_2 PF09011.5 ESA16066.1 - 0.019 15.3 0.3 0.035 14.4 0.2 1.5 1 0 0 1 1 1 0 HMG-box domain Toxin_trans PF07952.7 ESA16066.1 - 0.023 13.5 0.7 0.031 13.2 0.5 1.1 1 0 0 1 1 1 0 Clostridium neurotoxin, Translocation domain zf-AD PF07776.10 ESA16066.1 - 0.3 11.1 8.4 0.74 9.8 1.3 2.7 2 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) zf-C3HC4_3 PF13920.1 ESA16066.1 - 1 9.0 9.7 2.5 7.8 0.9 3.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc-ribbons_6 PF07191.7 ESA16066.1 - 1.4 8.7 9.5 12 5.7 6.3 2.3 1 1 1 2 2 2 0 zinc-ribbons DZR PF12773.2 ESA16066.1 - 4.4 7.1 9.1 38 4.2 6.3 2.4 1 1 0 1 1 1 0 Double zinc ribbon COG6 PF06419.6 ESA16067.1 - 8.9e-176 585.6 14.2 1.1e-175 585.4 9.9 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Aldo_ket_red PF00248.16 ESA16068.1 - 2.5e-64 216.8 0.0 2.9e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NAS PF03059.11 ESA16069.1 - 0.024 13.8 0.1 0.034 13.3 0.0 1.1 1 0 0 1 1 1 0 Nicotianamine synthase protein RVT_2 PF07727.9 ESA16069.1 - 0.082 11.8 0.1 0.088 11.7 0.1 1.0 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) ABC_tran_2 PF12848.2 ESA16071.1 - 0.011 15.4 5.0 0.62 9.9 1.1 2.1 2 0 0 2 2 2 0 ABC transporter DUF2031 PF09592.5 ESA16071.1 - 0.023 13.8 4.3 0.028 13.5 3.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2031) Endonuc-BglII PF09195.6 ESA16071.1 - 0.053 13.0 0.2 0.065 12.7 0.1 1.2 1 0 0 1 1 1 0 Restriction endonuclease BglII Microtub_assoc PF07989.6 ESA16071.1 - 0.063 13.1 1.3 0.12 12.1 0.9 1.4 1 0 0 1 1 1 0 Microtubule associated AKNA PF12443.3 ESA16071.1 - 0.093 12.7 0.8 0.14 12.1 0.5 1.3 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF972 PF06156.8 ESA16071.1 - 0.13 12.5 1.0 0.23 11.8 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CLTH PF10607.4 ESA16071.1 - 0.14 11.8 1.7 0.16 11.6 1.2 1.1 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain DivIC PF04977.10 ESA16071.1 - 0.17 11.4 1.7 0.3 10.5 1.2 1.5 1 0 0 1 1 1 0 Septum formation initiator Rootletin PF15035.1 ESA16071.1 - 0.26 11.2 3.2 0.18 11.7 1.0 1.5 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion zf-RVT PF13966.1 ESA16073.1 - 4.4e-05 23.7 0.4 4.4e-05 23.7 0.3 1.6 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Rad21_Rec8_N PF04825.8 ESA16075.1 - 2.1e-42 143.5 0.0 4.3e-42 142.5 0.0 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 ESA16075.1 - 1.6e-13 49.6 0.0 3.3e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 ESA16075.1 - 2.5e-06 27.2 3.5 3.1e-06 26.9 0.2 2.5 3 0 0 3 3 3 1 ScpA/B protein Syja_N PF02383.13 ESA16076.1 - 9.2e-98 326.9 0.0 2.9e-97 325.2 0.0 1.8 1 1 0 1 1 1 1 SacI homology domain hSac2 PF12456.3 ESA16076.1 - 3.8e-26 90.7 0.8 5.9e-26 90.1 0.0 1.7 2 0 0 2 2 2 1 Inositol phosphatase Adaptin_binding PF10199.4 ESA16076.1 - 0.0055 16.9 1.0 0.0055 16.9 0.7 2.3 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 YgbB PF02542.11 ESA16076.1 - 0.015 15.1 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 YgbB family DUF1048 PF06304.6 ESA16076.1 - 0.043 14.1 0.1 0.17 12.1 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) adh_short PF00106.20 ESA16077.1 - 8.5e-23 81.0 0.0 1.1e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA16077.1 - 1.8e-15 57.3 0.0 2.6e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.5 ESA16077.1 - 4.5e-13 49.0 0.8 3.4e-12 46.1 0.6 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.5 ESA16077.1 - 2.3e-05 24.1 0.0 3e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 ESA16077.1 - 0.0051 16.8 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 ESA16077.1 - 0.0052 16.2 0.0 0.027 13.8 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 ESA16077.1 - 0.021 14.1 0.0 0.037 13.2 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family CLN6 PF15156.1 ESA16077.1 - 0.058 12.4 0.6 0.14 11.1 0.1 1.8 2 0 0 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 6 NAD_binding_2 PF03446.10 ESA16077.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF3456 PF11938.3 ESA16078.1 - 0.00093 19.2 0.2 0.0016 18.4 0.1 1.5 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP RPAP3_C PF13877.1 ESA16078.1 - 0.018 15.0 0.0 0.052 13.5 0.0 1.8 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 SPOB_ab PF14682.1 ESA16080.1 - 0.015 15.1 1.2 0.042 13.6 0.2 2.2 2 0 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal BTB PF00651.26 ESA16081.1 - 3.4e-16 59.2 0.9 8e-16 58.0 0.2 1.9 2 0 0 2 2 2 1 BTB/POZ domain GWT1 PF06423.7 ESA16082.1 - 3.5e-39 134.0 4.2 3.5e-39 134.0 2.9 2.9 2 1 0 2 2 2 1 GWT1 DUF3357 PF11837.3 ESA16082.1 - 0.072 12.9 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) DUF872 PF05915.7 ESA16082.1 - 4.5 7.1 10.0 0.38 10.6 0.1 3.5 2 2 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Mg_trans_NIPA PF05653.9 ESA16084.1 - 0.033 13.1 0.4 0.036 13.0 0.3 1.1 1 0 0 1 1 1 0 Magnesium transporter NIPA T2SG PF08334.6 ESA16084.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G DUF1776 PF08643.5 ESA16085.1 - 0.14 11.2 0.2 0.23 10.5 0.1 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Renin_r PF07850.9 ESA16086.1 - 0.0045 17.3 1.6 0.0045 17.3 1.1 1.5 1 1 0 1 1 1 1 Renin receptor-like protein Sel1 PF08238.7 ESA16087.1 - 5.6e-49 163.4 14.1 3.2e-12 46.6 0.8 6.1 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA16087.1 - 0.0011 18.7 15.6 0.035 13.9 0.1 4.5 3 1 2 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA16087.1 - 0.0088 15.9 12.3 1.1 9.2 0.2 5.2 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16087.1 - 0.039 14.4 9.7 25 5.6 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16087.1 - 4.3 7.3 5.6 16 5.5 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat IF4E PF01652.13 ESA16088.1 - 1.6e-37 128.6 0.2 1.6e-37 128.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E WD40 PF00400.27 ESA16089.1 - 1.5e-19 69.0 15.5 3.1e-07 30.0 0.0 6.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Pkinase_Tyr PF07714.12 ESA16090.1 - 3.8e-19 68.7 0.0 9.5e-19 67.4 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16090.1 - 3.7e-15 55.7 0.0 8.3e-15 54.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Myb_DNA-bind_3 PF12776.2 ESA16090.1 - 0.5 11.0 4.2 23 5.6 1.3 2.3 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase_Tyr PF07714.12 ESA16091.1 - 0.0006 18.9 0.0 0.0013 17.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase ALMS_motif PF15309.1 ESA16091.1 - 0.015 15.1 1.5 0.057 13.2 0.0 2.0 2 0 0 2 2 2 0 ALMS motif Exo_endo_phos PF03372.18 ESA16092.1 - 9.1e-11 42.1 0.0 1.1e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family OGFr_N PF04664.8 ESA16092.1 - 0.068 12.4 0.0 8.9 5.5 0.0 2.9 3 0 0 3 3 3 0 Opioid growth factor receptor (OGFr) conserved region COG5 PF10392.4 ESA16093.1 - 7.3e-31 106.8 1.0 7.3e-31 106.8 0.7 3.4 4 0 0 4 4 4 1 Golgi transport complex subunit 5 Vps51 PF08700.6 ESA16093.1 - 1.7e-05 24.5 0.3 0.00026 20.7 0.1 3.1 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.1 ESA16093.1 - 0.0029 17.3 4.0 0.014 15.0 0.6 2.8 2 1 0 2 2 2 1 Exocyst complex component Sec5 DUF2450 PF10475.4 ESA16093.1 - 0.71 8.7 8.8 0.2 10.5 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function N-terminal domain (DUF2450) PPR_2 PF13041.1 ESA16094.1 - 1.1e-13 50.9 2.7 0.00012 21.9 0.2 3.7 2 1 1 3 3 3 3 PPR repeat family PPR_3 PF13812.1 ESA16094.1 - 5.6e-10 38.7 0.2 0.25 11.7 0.0 4.4 4 0 0 4 4 4 4 Pentatricopeptide repeat domain PPR PF01535.15 ESA16094.1 - 1.3e-09 37.3 2.6 0.15 12.0 0.2 4.5 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.2 ESA16094.1 - 0.00031 20.1 3.7 1.6 8.2 0.1 4.5 5 0 0 5 5 5 2 PPR repeat Peptidase_M3_N PF08439.5 ESA16095.1 - 0.071 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Oligopeptidase F Oxidored_q3 PF00499.15 ESA16096.1 - 0.056 13.2 0.2 0.077 12.7 0.1 1.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 RNA_pol_Rpb2_6 PF00562.23 ESA16097.1 - 5e-129 430.4 3.8 8.3e-129 429.6 2.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESA16097.1 - 2.6e-53 179.9 0.2 3.9e-53 179.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 ESA16097.1 - 1.4e-30 105.3 0.1 6.1e-30 103.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.9 ESA16097.1 - 2.4e-30 105.3 0.1 5.3e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 ESA16097.1 - 9e-24 83.0 0.0 2.2e-23 81.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESA16097.1 - 2.5e-16 59.3 1.2 5.7e-16 58.2 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.8 ESA16097.1 - 4e-12 45.7 0.1 1e-11 44.4 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 DDE_1 PF03184.14 ESA16098.1 - 1.3e-17 63.6 0.7 1.4e-17 63.5 0.5 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease FAM195 PF14799.1 ESA16098.1 - 0.076 12.8 0.5 0.11 12.3 0.4 1.5 1 1 0 1 1 1 0 FAM195 family DUF4251 PF14059.1 ESA16099.1 - 0.0023 17.7 0.2 0.0033 17.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4251) SapB_1 PF05184.10 ESA16099.1 - 0.037 13.8 1.3 0.12 12.2 0.4 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 rRNA_proc-arch PF13234.1 ESA16102.1 - 0.029 13.5 3.6 0.19 10.8 0.5 2.5 2 1 1 3 3 3 0 rRNA-processing arch domain Potyvirid-P3 PF13608.1 ESA16104.1 - 0.029 13.4 0.5 0.03 13.4 0.3 1.0 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein RNase_H PF00075.19 ESA16105.1 - 0.00087 19.6 0.1 0.0017 18.6 0.0 1.5 2 0 0 2 2 2 1 RNase H HisKA PF00512.20 ESA16106.1 - 5.2e-10 39.1 0.9 1.5e-09 37.7 0.6 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.21 ESA16106.1 - 0.0097 15.6 1.2 0.035 13.8 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PucR PF07905.6 ESA16106.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family SDA1 PF05285.7 ESA16107.1 - 0.0031 16.8 4.5 0.0035 16.6 3.1 1.1 1 0 0 1 1 1 1 SDA1 TFIIA PF03153.8 ESA16107.1 - 0.0099 15.8 4.9 0.011 15.6 3.4 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.7 ESA16107.1 - 0.24 9.2 6.7 0.27 9.1 4.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA16107.1 - 0.69 7.8 2.3 0.79 7.6 1.6 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.5 ESA16107.1 - 7.9 5.4 7.4 10 5.0 5.1 1.1 1 0 0 1 1 1 0 BUD22 DUF2871 PF11070.3 ESA16112.1 - 0.13 12.3 0.1 0.15 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) GST_N_3 PF13417.1 ESA16113.1 - 2.4e-14 53.2 0.0 3.9e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA16113.1 - 5.3e-12 45.7 0.0 7.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA16113.1 - 1.7e-07 31.1 0.0 2.6e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA16113.1 - 0.013 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.5 ESA16113.1 - 0.089 13.1 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 MetRS-N binding domain Glutaredoxin PF00462.19 ESA16113.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin GST_N_3 PF13417.1 ESA16114.1 - 4.8e-14 52.3 0.0 6.2e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA16114.1 - 1.6e-10 41.0 0.0 2e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA16114.1 - 1.4e-06 28.1 0.0 1.7e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GCR1_C PF12550.3 ESA16115.1 - 0.051 13.4 1.9 4.6 7.1 0.1 2.0 1 1 1 2 2 2 0 Transcriptional activator of glycolytic enzymes SHS2_FTSA PF02491.15 ESA16117.1 - 0.13 12.1 0.2 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA Cohesin_load PF10345.4 ESA16119.1 - 0.049 11.8 0.1 0.056 11.6 0.0 1.0 1 0 0 1 1 1 0 Cohesin loading factor DUF2365 PF10157.4 ESA16119.1 - 0.08 12.8 0.0 0.09 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) ProQ PF04352.8 ESA16119.1 - 0.15 11.6 0.6 0.18 11.4 0.4 1.2 1 0 0 1 1 1 0 ProQ/FINO family Ricin_B_lectin PF00652.17 ESA16122.1 - 0.012 15.6 0.1 0.03 14.3 0.1 1.7 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain F-box-like PF12937.2 ESA16123.1 - 0.00037 20.1 2.0 0.00037 20.1 1.4 2.0 2 0 0 2 2 2 1 F-box-like ABC_tran PF00005.22 ESA16125.1 - 4.6e-27 95.0 0.1 7.4e-27 94.3 0.1 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 ESA16125.1 - 4.6e-12 45.5 10.9 4.6e-12 45.5 7.5 1.5 2 0 0 2 2 1 1 ABC-2 type transporter AAA_16 PF13191.1 ESA16125.1 - 0.00039 20.4 0.0 0.00063 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 ESA16125.1 - 0.0012 18.0 0.2 0.0021 17.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 ESA16125.1 - 0.0017 17.4 10.2 0.0065 15.5 5.9 2.2 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.1 ESA16125.1 - 0.0032 17.4 0.4 2 8.3 0.0 2.3 1 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESA16125.1 - 0.047 13.2 1.2 0.1 12.1 0.8 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-synt_ab PF00006.20 ESA16125.1 - 0.067 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.1 ESA16125.1 - 0.072 13.2 0.0 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 ESA16125.1 - 0.098 13.4 0.1 0.22 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESA16125.1 - 0.12 12.5 0.9 0.76 9.9 0.6 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.22 ESA16125.1 - 0.16 11.4 0.2 0.76 9.1 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.1 ESA16125.1 - 0.17 11.8 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESA16125.1 - 0.54 10.0 1.5 0.99 9.1 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 GST_N_3 PF13417.1 ESA16128.1 - 6.2e-14 51.9 0.0 9.4e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 ESA16128.1 - 4.4e-12 45.9 0.0 6.3e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA16128.1 - 2.7e-08 33.7 0.0 4.1e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MetRS-N PF09635.5 ESA16128.1 - 0.038 14.3 0.0 0.052 13.9 0.0 1.3 1 0 0 1 1 1 0 MetRS-N binding domain GST_N_3 PF13417.1 ESA16129.1 - 4.9e-13 49.1 0.0 1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA16129.1 - 5e-13 48.8 0.0 8.3e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA16129.1 - 9.2e-12 44.9 0.0 1.4e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA16129.1 - 2.2e-08 33.9 0.0 3.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA16129.1 - 1.6e-07 31.1 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Leu_zip PF15294.1 ESA16130.1 - 0.00025 20.2 0.8 0.00025 20.2 0.6 1.1 1 0 0 1 1 1 1 Leucine zipper Shugoshin_N PF07558.6 ESA16130.1 - 0.0017 18.0 1.2 0.0032 17.1 0.8 1.5 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DivIC PF04977.10 ESA16130.1 - 0.0068 15.8 3.5 0.0072 15.7 1.0 1.9 1 1 1 2 2 2 1 Septum formation initiator Microtub_assoc PF07989.6 ESA16130.1 - 0.029 14.1 1.3 0.1 12.4 0.7 2.0 1 1 1 2 2 2 0 Microtubule associated bZIP_1 PF00170.16 ESA16130.1 - 0.063 13.2 3.8 0.13 12.1 2.4 1.8 1 1 1 2 2 2 0 bZIP transcription factor DUF972 PF06156.8 ESA16130.1 - 0.22 11.8 2.9 1.2 9.5 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HALZ PF02183.13 ESA16131.1 - 0.00092 18.8 1.5 0.0018 17.9 1.0 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper Shugoshin_N PF07558.6 ESA16131.1 - 0.002 17.8 0.8 0.0036 16.9 0.5 1.4 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Herpes_BLRF2 PF05812.7 ESA16131.1 - 0.02 14.6 0.5 0.028 14.2 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein DivIC PF04977.10 ESA16131.1 - 0.031 13.7 0.6 0.081 12.4 0.4 1.7 1 0 0 1 1 1 0 Septum formation initiator DUF972 PF06156.8 ESA16131.1 - 0.16 12.3 0.5 0.27 11.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) NYD-SP28_assoc PF14775.1 ESA16131.1 - 2.7 7.7 7.8 0.17 11.6 1.8 1.6 2 0 0 2 2 2 0 Sperm tail C-terminal domain IncA PF04156.9 ESA16131.1 - 5.2 6.6 6.9 11 5.5 0.8 2.2 2 0 0 2 2 2 0 IncA protein SET PF00856.23 ESA16133.1 - 1.3e-10 41.8 0.3 7.5e-10 39.3 0.0 2.4 2 2 0 2 2 2 1 SET domain Pkinase PF00069.20 ESA16134.1 - 1.3e-41 142.5 0.7 1.4e-41 142.3 0.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16134.1 - 1.1e-23 83.7 0.1 1.1e-23 83.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA16134.1 - 0.0084 15.4 0.1 0.012 15.0 0.1 1.2 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA16134.1 - 0.017 14.4 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA16134.1 - 0.025 13.6 0.1 0.042 12.8 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA16134.1 - 0.034 13.8 0.2 0.38 10.4 0.1 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family OAD_gamma PF04277.8 ESA16136.1 - 0.25 11.7 0.1 0.25 11.7 0.1 2.8 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain SPRY PF00622.23 ESA16138.1 - 1.2e-18 67.3 0.8 1.5e-18 67.0 0.6 1.0 1 0 0 1 1 1 1 SPRY domain Secretin_N_2 PF07655.8 ESA16141.1 - 2.1 8.7 14.3 3.5 8.0 9.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Mito_fiss_reg PF05308.6 ESA16141.1 - 3.3 7.0 5.8 3.8 6.8 4.0 1.0 1 0 0 1 1 1 0 Mitochondrial fission regulator VAD1-2 PF15310.1 ESA16144.1 - 0.046 13.3 0.2 0.049 13.2 0.2 1.0 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling DivIC PF04977.10 ESA16144.1 - 0.054 12.9 0.9 0.12 11.9 0.6 1.7 1 1 0 1 1 1 0 Septum formation initiator Packaging_FI PF14000.1 ESA16144.1 - 0.49 10.5 3.0 0.63 10.2 2.1 1.1 1 0 0 1 1 1 0 DNA packaging protein FI IncA PF04156.9 ESA16144.1 - 0.94 9.0 3.9 0.94 9.0 2.7 1.1 1 0 0 1 1 1 0 IncA protein SGT1 PF07093.6 ESA16145.1 - 8.5e-36 123.4 40.0 9.9e-36 123.2 27.7 1.0 1 0 0 1 1 1 1 SGT1 protein CBM_19 PF03427.8 ESA16146.1 - 0.0092 15.7 3.0 0.014 15.1 1.5 1.8 1 1 0 1 1 1 1 Carbohydrate binding domain (family 19) Lustrin_cystein PF14625.1 ESA16146.1 - 3.4 7.8 7.4 1.9 8.5 3.0 2.2 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Kelch_6 PF13964.1 ESA16147.1 - 6.7e-21 73.5 16.6 0.00064 19.7 0.0 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 ESA16147.1 - 1.6e-18 65.9 21.2 2e-06 27.2 0.7 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 ESA16147.1 - 2.1e-18 65.8 9.6 0.0085 16.0 0.0 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.10 ESA16147.1 - 7.1e-17 60.4 12.6 0.0052 16.5 0.0 6.7 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 ESA16147.1 - 3.7e-15 55.4 16.3 8.8e-06 25.4 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA16147.1 - 2.7e-13 49.6 12.9 1.5e-05 25.0 0.0 5.9 8 0 0 8 8 8 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA16148.1 - 1.1e-12 47.5 3.6 0.002 18.0 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 ESA16148.1 - 2.8e-12 46.2 0.6 0.00083 19.4 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.1 ESA16148.1 - 3.1e-12 46.2 2.9 0.0022 18.1 0.1 4.8 4 2 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA16148.1 - 1e-07 31.5 8.9 0.11 12.2 0.1 4.7 3 2 1 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA16148.1 - 1.3e-06 27.8 0.1 0.033 13.9 0.0 4.0 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA16148.1 - 1.2e-05 24.7 2.2 0.00044 19.7 0.1 3.2 2 1 0 2 2 2 1 Kelch motif Pkinase_Tyr PF07714.12 ESA16149.1 - 0.00066 18.8 0.0 0.00085 18.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16149.1 - 0.00084 18.5 0.0 0.0011 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain GON PF08685.6 ESA16151.1 - 3 7.6 6.2 2.9 7.6 1.8 2.0 1 1 1 2 2 2 0 GON domain Nbas_N PF15492.1 ESA16153.1 - 0.023 13.7 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal PI-PLC-Y PF00387.14 ESA16153.1 - 9 6.3 6.6 1.5 8.8 0.1 2.5 2 1 1 3 3 3 0 Phosphatidylinositol-specific phospholipase C, Y domain WD40 PF00400.27 ESA16154.1 - 0.00019 21.1 0.4 0.001 18.8 0.1 2.3 2 1 0 2 2 2 1 WD domain, G-beta repeat SET PF00856.23 ESA16155.1 - 2.1e-20 73.6 1.4 1.6e-19 70.7 0.1 3.1 3 1 0 3 3 3 1 SET domain EMP24_GP25L PF01105.19 ESA16156.1 - 1.3e-49 168.3 0.2 1.8e-49 167.9 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD B3_4 PF03483.12 ESA16157.1 - 1.7e-26 92.7 0.0 2.8e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 ESA16157.1 - 3.7e-20 71.5 0.0 2.6e-16 59.2 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetase B5 domain tRNA-synt_2d PF01409.15 ESA16157.1 - 0.037 13.2 0.0 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Ribosomal_S8 PF00410.14 ESA16158.1 - 1.2e-25 89.7 0.0 1.7e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Glyco_hydro_100 PF12899.2 ESA16158.1 - 0.082 11.2 0.0 0.082 11.2 0.0 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase Aminotran_3 PF00202.16 ESA16159.1 - 1.2e-107 359.6 0.0 1.8e-107 359.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 ESA16159.1 - 0.009 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 ESA16159.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II UMP1 PF05348.6 ESA16160.1 - 6.5e-39 132.8 0.1 7.8e-39 132.6 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Guanylate_kin PF00625.16 ESA16161.1 - 1.1e-66 223.8 0.0 1.3e-66 223.5 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 ESA16161.1 - 9.1e-09 35.3 0.0 3.6e-08 33.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA16161.1 - 5.9e-08 32.9 0.0 2e-07 31.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESA16161.1 - 1.1e-06 29.4 0.1 3.4e-05 24.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA16161.1 - 7e-06 26.2 0.0 5.3e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA16161.1 - 6.1e-05 23.3 0.1 0.00039 20.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA16161.1 - 0.00026 20.7 0.2 0.00086 19.0 0.1 1.8 1 1 0 1 1 1 1 Archaeal ATPase DUF258 PF03193.11 ESA16161.1 - 0.00029 20.0 0.0 0.00042 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA16161.1 - 0.00032 20.1 0.0 0.0023 17.4 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.22 ESA16161.1 - 0.00057 20.1 0.0 0.001 19.3 0.0 1.7 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.17 ESA16161.1 - 0.00069 19.7 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.7 ESA16161.1 - 0.00084 19.0 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.1 ESA16161.1 - 0.0011 18.9 0.0 0.002 17.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESA16161.1 - 0.0013 18.2 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain KAP_NTPase PF07693.9 ESA16161.1 - 0.0018 17.3 0.1 0.0085 15.1 0.0 1.9 1 1 0 1 1 1 1 KAP family P-loop domain Miro PF08477.8 ESA16161.1 - 0.0026 18.2 0.0 0.0063 16.9 0.0 1.7 2 0 0 2 2 1 1 Miro-like protein T2SE PF00437.15 ESA16161.1 - 0.0062 15.4 0.0 0.012 14.5 0.0 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.1 ESA16161.1 - 0.013 15.8 0.6 0.19 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 ESA16161.1 - 0.014 15.4 0.0 0.03 14.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESA16161.1 - 0.014 14.3 0.0 0.02 13.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA PF00004.24 ESA16161.1 - 0.014 15.6 0.0 0.54 10.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.14 ESA16161.1 - 0.014 14.8 0.1 0.05 13.0 0.0 1.9 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.18 ESA16161.1 - 0.015 15.2 0.0 0.02 14.8 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.1 ESA16161.1 - 0.017 14.8 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Zeta_toxin PF06414.7 ESA16161.1 - 0.017 14.1 0.1 0.27 10.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Sigma54_activ_2 PF14532.1 ESA16161.1 - 0.027 14.5 0.0 0.076 13.0 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 ESA16161.1 - 0.038 13.4 0.0 0.058 12.9 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 ESA16161.1 - 0.039 13.4 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain KTI12 PF08433.5 ESA16161.1 - 0.044 12.9 0.1 0.083 12.0 0.0 1.4 2 0 0 2 2 1 0 Chromatin associated protein KTI12 NB-ARC PF00931.17 ESA16161.1 - 0.058 12.2 0.0 0.27 10.0 0.0 1.9 1 1 1 2 2 2 0 NB-ARC domain AAA_30 PF13604.1 ESA16161.1 - 0.062 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.7 ESA16161.1 - 0.07 12.4 0.0 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Poxvirus A32 protein NTPase_1 PF03266.10 ESA16161.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 NTPase ATP_bind_1 PF03029.12 ESA16161.1 - 0.076 12.5 0.1 0.47 9.9 0.0 2.2 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein MobB PF03205.9 ESA16161.1 - 0.082 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 ESA16161.1 - 0.089 12.3 0.2 0.15 11.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain PC-Esterase PF13839.1 ESA16162.1 - 0.00021 21.2 0.2 0.0004 20.2 0.1 1.7 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p WD40 PF00400.27 ESA16163.1 - 5e-14 51.5 8.5 0.00095 18.9 0.1 5.2 4 0 0 4 4 4 4 WD domain, G-beta repeat RabGAP-TBC PF00566.13 ESA16165.1 - 2.9e-57 193.5 0.3 2.9e-57 193.5 0.2 1.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF2457 PF10446.4 ESA16165.1 - 0.04 12.6 1.3 0.055 12.1 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MRP-S31 PF15433.1 ESA16165.1 - 0.049 13.0 0.1 0.06 12.7 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Transposase_21 PF02992.9 ESA16166.1 - 0.0042 16.1 1.0 0.0048 16.0 0.1 1.5 2 0 0 2 2 2 1 Transposase family tnp2 NdhO PF11910.3 ESA16167.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Cyanobacterial and plant NDH-1 subunit O MRI PF15325.1 ESA16168.1 - 0.0079 17.1 1.7 0.0086 17.0 1.2 1.0 1 0 0 1 1 1 1 Modulator of retrovirus infection ETRAMP PF09716.5 ESA16168.1 - 0.065 13.2 5.1 0.1 12.5 3.5 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SR-25 PF10500.4 ESA16168.1 - 0.089 12.2 15.1 0.11 11.9 10.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRP1_N PF06424.7 ESA16168.1 - 1.2 9.5 9.5 1.3 9.3 6.6 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal SID-1_RNA_chan PF13965.1 ESA16168.1 - 2 6.4 5.2 2.1 6.4 3.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Peptidase_S49_N PF08496.5 ESA16168.1 - 4.8 6.9 10.4 7 6.4 7.2 1.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal KIAA1430 PF13879.1 ESA16169.1 - 0.024 15.0 4.1 0.033 14.6 2.8 1.2 1 0 0 1 1 1 0 KIAA1430 homologue bZIP_1 PF00170.16 ESA16170.1 - 0.035 14.0 2.7 0.1 12.5 0.4 2.0 1 1 1 2 2 2 0 bZIP transcription factor DUF4201 PF13870.1 ESA16170.1 - 0.066 12.6 0.3 0.11 11.9 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Nup54 PF13874.1 ESA16170.1 - 0.093 12.3 0.4 0.1 12.2 0.3 1.1 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF2312 PF10073.4 ESA16170.1 - 0.097 12.0 0.2 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF2163 PF09931.4 ESA16170.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) bZIP_2 PF07716.10 ESA16170.1 - 0.12 12.2 1.9 5.8 6.8 0.2 2.3 1 1 1 2 2 2 0 Basic region leucine zipper NST1 PF13945.1 ESA16170.1 - 0.17 11.9 1.7 0.17 11.9 1.2 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator M PF02370.11 ESA16170.1 - 1.7 9.2 6.6 17 6.1 0.1 2.8 3 1 0 3 3 3 0 M protein repeat p450 PF00067.17 ESA16172.1 - 6.6e-05 21.6 0.1 7.1e-05 21.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4474 PF14751.1 ESA16172.1 - 0.0096 15.1 0.0 0.015 14.4 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4474) RTTN_N PF14726.1 ESA16172.1 - 0.14 12.7 0.3 0.2 12.2 0.2 1.3 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning Pkinase_Tyr PF07714.12 ESA16174.1 - 9.5e-36 123.1 0.0 1e-35 123.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16174.1 - 9.2e-29 100.3 0.0 1e-28 100.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain MORN_2 PF07661.8 ESA16174.1 - 0.25 11.4 1.6 0.7 10.1 0.2 2.4 3 0 0 3 3 3 0 MORN repeat variant DUF573 PF04504.9 ESA16177.1 - 0.0089 16.2 0.9 0.033 14.4 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF573 MIR PF02815.14 ESA16177.1 - 0.019 14.4 1.4 0.7 9.3 0.0 2.9 1 1 1 3 3 3 0 MIR domain DUF1684 PF07920.6 ESA16178.1 - 0.018 14.9 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1684) Pox_VLTF3 PF04947.9 ESA16179.1 - 0.0055 16.2 3.1 0.0077 15.7 2.1 1.2 1 0 0 1 1 1 1 Poxvirus Late Transcription Factor VLTF3 like LMF1 PF06762.9 ESA16179.1 - 0.053 12.3 0.7 0.06 12.1 0.5 1.1 1 0 0 1 1 1 0 Lipase maturation factor DSL PF01414.14 ESA16179.1 - 0.21 11.5 3.3 2.2 8.3 0.1 3.0 3 0 0 3 3 3 0 Delta serrate ligand AIB PF15334.1 ESA16180.1 - 0.0024 16.9 7.9 0.003 16.6 1.2 2.0 1 1 1 2 2 2 2 Aurora kinase A and ninein interacting protein IFT57 PF10498.4 ESA16180.1 - 0.0064 15.2 2.0 0.0067 15.2 1.4 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Flavodoxin_5 PF12724.2 ESA16180.1 - 0.081 12.9 0.9 0.12 12.3 0.6 1.5 1 1 0 1 1 1 0 Flavodoxin domain YgaB PF14182.1 ESA16180.1 - 0.082 13.1 1.7 0.25 11.6 0.4 2.2 1 1 1 2 2 2 0 YgaB-like protein DUF948 PF06103.6 ESA16180.1 - 0.15 11.8 1.6 0.36 10.7 0.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BRE1 PF08647.6 ESA16181.1 - 0.016 15.1 1.1 0.37 10.7 0.2 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Chordopox_A30L PF06015.7 ESA16181.1 - 0.017 14.7 0.5 0.042 13.4 0.3 1.7 1 1 0 1 1 1 0 Chordopoxvirus A30L protein DUF4200 PF13863.1 ESA16181.1 - 0.019 14.9 0.6 0.024 14.5 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF148 PF02520.12 ESA16181.1 - 0.039 13.7 0.5 0.041 13.6 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF148 SspH PF08141.7 ESA16181.1 - 0.041 13.9 0.1 1.6 8.8 0.0 2.3 3 0 0 3 3 3 0 Small acid-soluble spore protein H family Prefoldin PF02996.12 ESA16181.1 - 0.047 13.3 0.6 1.2 8.8 0.1 2.0 1 1 1 2 2 2 0 Prefoldin subunit Arfaptin PF06456.8 ESA16181.1 - 0.058 12.7 0.2 0.21 10.9 0.2 1.8 1 1 0 1 1 1 0 Arfaptin-like domain Erp_C PF06780.6 ESA16181.1 - 0.083 12.7 0.2 0.2 11.4 0.1 1.6 1 1 1 2 2 2 0 Erp protein C-terminus RICH PF05062.7 ESA16181.1 - 0.11 12.6 1.8 0.13 12.4 1.2 1.2 1 0 0 1 1 1 0 RICH domain Cytochrom_C_2 PF01322.15 ESA16181.1 - 0.19 12.3 0.8 0.19 12.2 0.5 1.1 1 0 0 1 1 1 0 Cytochrome C' 4HB_MCP_1 PF12729.2 ESA16181.1 - 0.2 11.0 1.0 0.21 10.9 0.7 1.0 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DMPK_coil PF08826.5 ESA16181.1 - 0.36 10.7 3.3 1.5 8.7 1.9 2.2 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF3389 PF11869.3 ESA16182.1 - 0.071 13.0 0.1 0.085 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3389) zf-BED PF02892.10 ESA16184.1 - 0.00026 20.7 2.0 0.00059 19.5 1.4 1.6 1 0 0 1 1 1 1 BED zinc finger DUF3508 PF12018.3 ESA16184.1 - 0.005 15.8 0.1 0.0061 15.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3508) HBS1_N PF08938.5 ESA16185.1 - 0.027 14.5 0.1 0.031 14.4 0.1 1.1 1 0 0 1 1 1 0 HBS1 N-terminus Acylphosphatase PF00708.13 ESA16186.1 - 0.064 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Acylphosphatase DSS1_SEM1 PF05160.8 ESA16188.1 - 1.7e-20 72.5 21.5 1.7e-20 72.5 14.9 1.5 1 1 1 2 2 2 1 DSS1/SEM1 family FAM195 PF14799.1 ESA16188.1 - 0.011 15.5 3.1 0.015 15.1 2.2 1.2 1 0 0 1 1 1 0 FAM195 family Smg4_UPF3 PF03467.10 ESA16188.1 - 0.27 11.2 3.0 0.32 10.9 2.1 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family Spore_coat_CotO PF14153.1 ESA16188.1 - 2.3 7.5 8.9 2.5 7.5 6.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO RhoGAP PF00620.22 ESA16189.1 - 6e-50 168.8 0.0 1.4e-49 167.5 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain Myb_DNA-bind_6 PF13921.1 ESA16191.1 - 4.8e-67 221.9 37.9 6.5e-09 35.7 0.5 10.4 9 1 1 10 10 10 10 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA16191.1 - 3.7e-61 202.9 14.3 9.4e-09 35.1 0.0 10.4 10 0 0 10 10 10 10 Myb-like DNA-binding domain Nop16 PF09420.5 ESA16191.1 - 0.006 16.6 5.9 9.7 6.2 0.0 6.2 6 1 0 7 7 7 1 Ribosome biogenesis protein Nop16 Death PF00531.17 ESA16191.1 - 0.043 13.5 0.0 6 6.7 0.0 3.4 2 0 0 2 2 2 0 Death domain VPS11_C PF12451.3 ESA16191.1 - 0.054 13.3 0.1 0.24 11.3 0.1 2.1 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Myb_DNA-bind_5 PF13873.1 ESA16191.1 - 0.65 9.9 16.2 2.4 8.0 0.0 7.3 8 2 1 9 9 9 0 Myb/SANT-like DNA-binding domain DUF4479 PF14794.1 ESA16191.1 - 0.89 9.1 4.0 23 4.5 0.0 4.5 6 0 0 6 6 6 0 Domain of unknown function (DUF4479) WIYLD PF10440.4 ESA16191.1 - 7.7 6.5 29.6 3.2 7.7 0.1 7.6 9 0 0 9 9 9 0 Ubiquitin-binding WIYLD domain p450 PF00067.17 ESA16192.1 - 1.9e-45 155.2 0.1 2.2e-45 155.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.13 ESA16193.1 - 3.4e-07 30.0 16.0 5.2e-07 29.4 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain mRNA_stabil PF13929.1 ESA16193.1 - 0.089 11.7 0.1 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 mRNA stabilisation zf-BED PF02892.10 ESA16194.1 - 2.9e-07 30.1 0.1 5.9e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 BED zinc finger zf-TRAF PF02176.13 ESA16194.1 - 0.038 14.3 0.4 0.038 14.3 0.3 1.5 2 0 0 2 2 2 0 TRAF-type zinc finger zf-H2C2_2 PF13465.1 ESA16194.1 - 0.046 14.0 2.6 0.049 13.9 0.7 1.9 2 1 0 2 2 2 0 Zinc-finger double domain RVT_1 PF00078.22 ESA16196.1 - 0.00031 20.1 0.2 0.00047 19.5 0.2 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Lipoprotein_17 PF04200.7 ESA16196.1 - 0.14 12.3 4.8 0.4 10.8 3.3 1.8 1 0 0 1 1 1 0 Lipoprotein associated domain APG6 PF04111.7 ESA16197.1 - 0.1 11.6 7.9 0.16 10.9 5.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF722 PF05263.6 ESA16197.1 - 0.27 11.3 6.8 0.1 12.7 2.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF722) RRM_1 PF00076.17 ESA16200.1 - 5.5e-19 67.5 0.1 6.2e-19 67.4 0.1 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA16200.1 - 5.5e-15 55.1 0.1 6.7e-15 54.8 0.1 1.0 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA16200.1 - 2.3e-12 46.5 0.0 2.8e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SCP2 PF02036.12 ESA16201.1 - 1.3e-24 86.3 1.2 1.6e-24 86.1 0.8 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 ESA16201.1 - 1.5e-06 28.2 0.8 2.2e-06 27.6 0.6 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Acetyltransf_1 PF00583.19 ESA16202.1 - 3.5e-10 39.7 0.0 6.1e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 ESA16202.1 - 7e-09 35.3 0.0 4.4e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.1 ESA16202.1 - 2.4e-07 30.8 0.0 4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA16202.1 - 5.4e-05 23.2 0.0 7.7e-05 22.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA16202.1 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Borrelia_lipo_1 PF05714.6 ESA16202.1 - 0.012 14.7 4.6 0.017 14.2 3.2 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Acetyltransf_CG PF14542.1 ESA16202.1 - 0.022 14.6 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.1 ESA16202.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.1 ESA16202.1 - 0.054 12.8 0.3 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase 2 DUF2251 PF10008.4 ESA16203.1 - 0.016 15.3 1.3 0.026 14.6 0.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) DUF1640 PF07798.6 ESA16204.1 - 0.04 13.9 2.4 0.084 12.9 1.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) AAA_14 PF13173.1 ESA16205.1 - 0.052 13.4 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Fungal_trans PF04082.13 ESA16210.1 - 6.5e-37 126.8 1.5 1.6e-36 125.5 1.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ESA16210.1 - 1.6e-10 40.7 10.3 2.9e-10 39.9 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Alpha_kinase PF02816.13 ESA16211.1 - 1.7e-36 125.6 1.0 2.7e-36 124.9 0.7 1.3 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA16211.1 - 0.043 13.9 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain Alpha_kinase PF02816.13 ESA16212.1 - 0.00035 20.2 0.0 0.00043 19.9 0.0 1.1 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.7 ESA16214.1 - 3.1e-05 24.4 0.1 0.00033 21.1 0.0 2.1 2 0 0 2 2 2 1 Sel1 repeat POLO_box PF00659.13 ESA16215.1 - 0.092 12.7 2.0 42 4.2 0.0 3.5 3 0 0 3 3 3 0 POLO box duplicated region DUF3662 PF12401.3 ESA16215.1 - 0.12 12.5 0.1 4.6 7.4 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2662) LRR_8 PF13855.1 ESA16217.1 - 0.01 15.5 3.0 0.23 11.2 0.1 3.6 3 1 0 3 3 3 0 Leucine rich repeat FTH PF01827.22 ESA16217.1 - 0.017 14.6 4.2 1.3 8.5 0.2 3.0 2 2 0 2 2 2 0 FTH domain LRR_6 PF13516.1 ESA16217.1 - 0.15 12.1 2.2 2.7 8.3 0.1 3.3 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.2 ESA16217.1 - 2.7 7.7 10.7 1.5 8.5 0.2 4.2 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.12 ESA16218.1 - 4e-14 52.3 0.0 5.1e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16218.1 - 6.4e-10 38.6 0.0 1.1e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain zinc-ribbons_6 PF07191.7 ESA16218.1 - 0.011 15.5 0.5 0.019 14.7 0.4 1.3 1 0 0 1 1 1 0 zinc-ribbons Stc1 PF12898.2 ESA16218.1 - 0.063 13.3 0.5 0.1 12.6 0.4 1.3 1 0 0 1 1 1 0 Stc1 domain ABM PF03992.11 ESA16218.1 - 0.11 12.5 0.0 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase DnaJ PF00226.26 ESA16220.1 - 4.6e-24 83.9 0.6 8.1e-24 83.1 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.4 ESA16220.1 - 4.5e-16 59.1 37.9 1.6e-06 27.8 4.5 3.2 2 1 1 3 3 3 3 Transmembrane Fragile-X-F protein DUF788 PF05620.6 ESA16220.1 - 0.24 11.2 0.0 0.24 11.2 0.0 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF788) Mgr1 PF08602.5 ESA16221.1 - 0.012 14.6 0.4 0.017 14.1 0.3 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DUF2972 PF11186.3 ESA16221.1 - 0.4 10.5 5.2 0.99 9.2 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2972) Clathrin PF00637.15 ESA16224.1 - 5e-81 269.3 18.0 1.8e-35 121.6 0.9 4.4 4 0 0 4 4 4 3 Region in Clathrin and VPS Clathrin_propel PF01394.15 ESA16224.1 - 5.9e-29 98.3 0.2 2e-06 27.6 0.0 7.6 7 0 0 7 7 7 7 Clathrin propeller repeat Clathrin_H_link PF13838.1 ESA16224.1 - 9e-29 99.1 0.5 4.9e-28 96.8 0.1 2.4 2 0 0 2 2 2 1 Clathrin-H-link TPR_19 PF14559.1 ESA16224.1 - 8.7e-07 29.1 3.3 0.89 9.9 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat Clathrin-link PF09268.5 ESA16224.1 - 3.9e-05 22.5 2.8 0.00016 20.6 2.0 2.1 1 1 0 1 1 1 1 Clathrin, heavy-chain linker TPR_12 PF13424.1 ESA16224.1 - 0.018 14.9 0.6 3.7 7.5 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16224.1 - 0.13 12.1 0.5 19 5.3 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TAF4 PF05236.9 ESA16225.1 - 1.8e-30 106.1 9.2 4.1e-30 104.9 6.4 1.5 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family SAGA-Tad1 PF12767.2 ESA16225.1 - 0.0028 17.3 0.0 0.0028 17.3 0.0 2.3 2 1 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit GAGA_bind PF06217.7 ESA16225.1 - 0.17 11.7 4.4 0.24 11.3 3.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF1764 PF08576.5 ESA16225.1 - 0.29 11.9 4.5 0.73 10.6 3.1 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3385 PF11865.3 ESA16227.1 - 6.9e-64 214.5 1.1 1.1e-61 207.4 0.1 4.3 4 2 1 5 5 5 1 Domain of unknown function (DUF3385) HEAT PF02985.17 ESA16227.1 - 5.9e-20 69.5 11.2 0.0086 16.0 0.0 11.1 11 0 0 11 11 10 4 HEAT repeat HEAT_EZ PF13513.1 ESA16227.1 - 9.1e-20 70.5 19.9 1.2e-07 31.9 0.3 11.3 12 2 2 14 14 13 3 HEAT-like repeat HEAT_2 PF13646.1 ESA16227.1 - 4e-19 68.6 12.6 3.5e-05 23.9 1.4 8.6 4 3 3 7 7 7 5 HEAT repeats CLASP_N PF12348.3 ESA16227.1 - 5.7e-11 42.1 0.8 0.18 11.1 0.0 6.8 5 3 3 8 8 8 3 CLASP N terminal Vac14_Fab1_bd PF12755.2 ESA16227.1 - 3.4e-10 40.1 0.8 3.1 8.2 0.0 7.9 6 1 2 8 8 8 2 Vacuolar 14 Fab1-binding region Proteasom_PSMB PF10508.4 ESA16227.1 - 4.6e-05 21.8 7.6 0.032 12.5 0.4 2.7 2 0 0 2 2 2 2 Proteasome non-ATPase 26S subunit MMS19_C PF12460.3 ESA16227.1 - 0.00011 21.1 9.7 0.028 13.1 0.2 5.1 4 1 0 5 5 5 2 RNAPII transcription regulator C-terminal DUF2454 PF10521.4 ESA16227.1 - 0.00028 19.9 8.1 0.44 9.4 0.1 5.3 3 1 1 5 5 5 2 Protein of unknown function (DUF2454) Fanconi_C PF02106.10 ESA16227.1 - 0.018 13.5 0.3 0.07 11.5 0.0 1.9 1 1 1 2 2 2 0 Fanconi anaemia group C protein DUF1678 PF07913.6 ESA16227.1 - 0.024 14.2 0.6 3.5 7.1 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1678) Vitellogenin_N PF01347.17 ESA16227.1 - 0.042 12.0 0.0 5.4 5.1 0.0 2.7 2 1 0 2 2 2 0 Lipoprotein amino terminal region G-alpha PF00503.15 ESA16228.1 - 7.7e-124 413.3 1.1 9.5e-124 413.0 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 ESA16228.1 - 7.8e-16 57.8 0.2 2.1e-10 40.1 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA16228.1 - 0.00025 20.2 0.1 0.44 9.6 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA16228.1 - 0.0011 19.4 0.0 0.5 10.8 0.0 2.9 3 0 0 3 3 3 1 Miro-like protein GTP_EFTU PF00009.22 ESA16228.1 - 0.024 14.0 0.0 1.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ESA16228.1 - 0.034 13.6 0.0 0.081 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain C1_1 PF00130.17 ESA16229.1 - 3.4e-12 45.9 10.8 1.3e-07 31.2 2.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) UNC-79 PF14776.1 ESA16229.1 - 5.1e-05 21.8 0.1 0.0004 18.9 0.0 2.2 2 0 0 2 2 2 1 Cation-channel complex subunit UNC-79 MYCBPAP PF14646.1 ESA16229.1 - 0.087 11.5 0.1 0.14 10.8 0.1 1.2 1 0 0 1 1 1 0 MYCBP-associated protein family PHD_2 PF13831.1 ESA16229.1 - 0.092 12.0 7.0 0.11 11.8 0.1 2.8 2 0 0 2 2 2 0 PHD-finger PHD PF00628.24 ESA16229.1 - 0.41 10.3 14.3 0.63 9.7 0.8 2.7 2 0 0 2 2 2 0 PHD-finger zf-RING-like PF08746.6 ESA16229.1 - 0.6 10.1 15.5 2.7 8.0 1.4 2.6 2 0 0 2 2 2 0 RING-like domain FYVE_2 PF02318.11 ESA16229.1 - 0.73 9.7 6.9 0.26 11.2 1.1 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger C1_3 PF07649.7 ESA16229.1 - 0.8 9.7 13.3 1.8 8.6 1.4 2.9 2 0 0 2 2 2 0 C1-like domain CWC25 PF12542.3 ESA16230.1 - 0.035 14.5 1.0 0.044 14.2 0.7 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor Alpha_kinase PF02816.13 ESA16231.1 - 1.2e-36 126.1 0.9 2.1e-36 125.3 0.6 1.4 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA16231.1 - 0.00057 20.0 0.0 0.00086 19.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF310 PF03750.8 ESA16231.1 - 0.036 14.2 0.9 0.13 12.4 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF310) DivIC PF04977.10 ESA16232.1 - 0.015 14.7 1.2 0.021 14.2 0.8 1.3 1 0 0 1 1 1 0 Septum formation initiator Microtub_assoc PF07989.6 ESA16232.1 - 0.021 14.6 1.6 0.05 13.4 0.8 1.9 1 1 1 2 2 2 0 Microtubule associated Phasin PF05597.6 ESA16232.1 - 0.035 13.8 0.4 0.051 13.3 0.3 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF724 PF05266.9 ESA16232.1 - 0.16 11.6 3.8 0.21 11.1 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.6 ESA16232.1 - 0.32 10.9 2.3 2.5 8.0 1.6 2.1 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Pkinase PF00069.20 ESA16237.1 - 3e-07 29.8 0.0 4.1e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16237.1 - 2.3e-06 26.8 0.0 2.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Orthopox_F7 PF05813.7 ESA16237.1 - 0.029 14.2 0.3 0.036 13.9 0.2 1.3 1 0 0 1 1 1 0 Orthopoxvirus F7 protein UBX PF00789.15 ESA16239.1 - 9.7e-12 44.7 0.0 2.4e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.1 ESA16239.1 - 0.00032 20.6 0.0 0.00086 19.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like FliD_N PF02465.13 ESA16240.1 - 0.027 14.8 0.4 0.051 13.9 0.3 1.6 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus RRM_6 PF14259.1 ESA16240.1 - 0.05 13.5 0.0 0.094 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Astro_capsid PF03115.9 ESA16240.1 - 0.074 11.2 4.5 0.077 11.2 3.1 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor RP-C_C PF11800.3 ESA16240.1 - 0.38 10.4 4.6 0.5 10.0 3.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region COQ7 PF03232.8 ESA16240.1 - 0.62 9.5 6.2 0.13 11.7 1.0 2.0 1 1 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 IncA PF04156.9 ESA16240.1 - 0.86 9.1 7.6 0.64 9.5 4.2 1.5 1 1 0 1 1 1 0 IncA protein CENP-Q PF13094.1 ESA16240.1 - 7.2 6.6 11.4 2.8 7.9 5.6 2.0 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit eIF-3_zeta PF05091.7 ESA16244.1 - 7.3e-148 493.3 5.2 3.5e-89 299.7 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Snapin_Pallidin PF14712.1 ESA16245.1 - 6.2e-18 64.8 1.8 8.1e-18 64.5 1.3 1.2 1 0 0 1 1 1 1 Snapin/Pallidin NAD_binding_3 PF03447.11 ESA16245.1 - 0.00067 20.0 0.1 0.00078 19.8 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF489 PF04356.7 ESA16245.1 - 0.0027 17.3 0.5 0.003 17.1 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF489) TBPIP PF07106.8 ESA16245.1 - 0.0031 17.0 1.5 0.0045 16.5 1.1 1.3 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Laminin_II PF06009.7 ESA16245.1 - 0.0035 17.1 2.6 0.0058 16.3 1.8 1.4 1 0 0 1 1 1 1 Laminin Domain II DivIC PF04977.10 ESA16245.1 - 0.0085 15.5 3.3 1 8.9 0.1 2.2 2 0 0 2 2 2 2 Septum formation initiator DUF1664 PF07889.7 ESA16245.1 - 0.0097 15.7 1.7 0.014 15.1 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Shikimate_DH PF01488.15 ESA16245.1 - 0.019 15.0 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Membr_traf_MHD PF10540.4 ESA16245.1 - 0.033 13.9 0.2 0.059 13.1 0.1 1.4 1 1 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain Spc7 PF08317.6 ESA16245.1 - 0.038 12.6 3.7 0.046 12.3 2.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Dna2 PF08696.6 ESA16245.1 - 0.082 12.2 0.3 0.15 11.3 0.2 1.5 1 1 0 1 1 1 0 DNA replication factor Dna2 FlgN PF05130.7 ESA16245.1 - 0.086 13.0 1.3 0.11 12.7 0.9 1.2 1 0 0 1 1 1 0 FlgN protein ZapA PF05164.8 ESA16245.1 - 0.089 12.7 0.7 0.15 12.0 0.5 1.3 1 0 0 1 1 1 0 Cell division protein ZapA MCC-bdg_PDZ PF10506.4 ESA16245.1 - 0.1 12.4 0.1 0.1 12.4 0.1 2.4 3 1 0 3 3 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Baculo_PEP_C PF04513.7 ESA16245.1 - 0.12 12.2 0.7 0.17 11.6 0.5 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Kinetocho_Slk19 PF12709.2 ESA16245.1 - 0.13 12.3 2.5 3.4 7.8 0.2 2.3 2 0 0 2 2 2 0 Central kinetochore-associated bZIP_1 PF00170.16 ESA16245.1 - 0.16 11.9 5.4 0.86 9.6 0.5 2.3 2 0 0 2 2 2 0 bZIP transcription factor BLOC1_2 PF10046.4 ESA16245.1 - 0.24 11.5 2.3 3.3 7.9 0.3 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-ZPR1 PF03367.8 ESA16245.1 - 0.31 10.1 1.8 0.69 9.0 0.2 1.9 1 1 1 2 2 2 0 ZPR1 zinc-finger domain XhlA PF10779.4 ESA16245.1 - 0.36 10.7 2.2 4.2 7.3 1.5 2.3 1 1 0 1 1 1 0 Haemolysin XhlA Fez1 PF06818.10 ESA16245.1 - 0.43 10.5 3.2 12 5.8 0.1 2.0 1 1 1 2 2 2 0 Fez1 DUF2730 PF10805.3 ESA16245.1 - 0.75 9.5 3.6 2.3 7.9 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Seryl_tRNA_N PF02403.17 ESA16245.1 - 0.85 9.6 4.5 7.1 6.6 3.1 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Prefoldin PF02996.12 ESA16245.1 - 0.95 9.1 4.3 11 5.6 0.5 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF948 PF06103.6 ESA16245.1 - 1.1 9.1 3.6 16 5.3 0.6 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin_2 PF01920.15 ESA16245.1 - 1.2 8.9 5.8 6 6.6 0.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit Vps51 PF08700.6 ESA16245.1 - 1.3 8.9 4.5 16 5.4 0.1 2.3 2 0 0 2 2 2 0 Vps51/Vps67 DUF972 PF06156.8 ESA16245.1 - 2.5 8.4 5.6 5.3 7.4 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF4200 PF13863.1 ESA16245.1 - 9.3 6.2 8.4 2e+02 1.9 5.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Tmemb_9 PF05434.6 ESA16246.1 - 2.8 7.6 6.4 0.69 9.6 1.8 1.8 2 0 0 2 2 2 0 TMEM9 Peptidase_C37 PF05416.7 ESA16247.1 - 0.04 12.2 1.1 0.042 12.1 0.7 1.0 1 0 0 1 1 1 0 Southampton virus-type processing peptidase MCRS_N PF13325.1 ESA16247.1 - 0.05 13.1 0.2 0.057 12.9 0.1 1.2 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein UPF0180 PF03698.8 ESA16247.1 - 0.08 12.7 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) UDPGT PF00201.13 ESA16248.1 - 3.3e-12 45.7 0.0 1.1e-11 43.9 0.0 1.7 1 1 1 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Nop PF01798.13 ESA16249.1 - 8.7e-60 200.3 1.2 2.2e-59 199.0 0.8 1.7 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 ESA16249.1 - 1.1e-27 95.6 0.1 2.5e-27 94.4 0.0 1.7 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 ESA16249.1 - 4.3e-20 71.6 0.6 1.3e-19 70.1 0.4 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain DUF3209 PF11483.3 ESA16249.1 - 0.1 12.9 0.1 0.27 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) TPR_11 PF13414.1 ESA16250.1 - 6e-14 51.4 0.7 1.9e-06 27.4 0.1 2.5 2 0 0 2 2 2 2 TPR repeat SHNi-TPR PF10516.4 ESA16250.1 - 3.5e-12 45.3 1.7 3.6e-11 42.1 0.0 3.4 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.1 ESA16250.1 - 1.8e-10 40.5 2.1 3.4e-05 23.6 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16250.1 - 2.6e-08 33.1 0.7 0.0099 15.4 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16250.1 - 2.1e-07 30.3 4.3 0.053 13.4 0.0 4.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16250.1 - 0.00013 22.5 0.4 0.054 14.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16250.1 - 0.0047 16.6 3.2 0.25 11.1 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TOM20_plant PF06552.7 ESA16250.1 - 0.008 15.7 0.7 0.057 13.0 0.0 2.5 2 0 0 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_7 PF13176.1 ESA16250.1 - 0.012 15.3 1.0 19 5.3 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat CRISPR_Cse1 PF09481.5 ESA16250.1 - 0.042 12.5 0.0 0.069 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) Exonuc_VII_S PF02609.11 ESA16250.1 - 0.13 12.0 0.2 0.13 12.0 0.1 3.9 4 0 0 4 4 4 0 Exonuclease VII small subunit DUF2443 PF10398.4 ESA16250.1 - 0.29 10.9 4.2 0.28 11.0 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) MRP-L28 PF09812.4 ESA16250.1 - 0.57 9.9 9.4 0.096 12.5 1.6 2.8 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L28 DUF1664 PF07889.7 ESA16250.1 - 1.1 9.1 11.2 0.16 11.7 2.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4398 PF14346.1 ESA16250.1 - 2 8.5 7.1 9.1 6.3 1.4 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4398) PEP-utilisers_N PF05524.8 ESA16250.1 - 8.8 6.1 7.6 1.8 8.4 1.6 2.6 2 1 1 3 3 2 0 PEP-utilising enzyme, N-terminal WD40 PF00400.27 ESA16251.1 - 2.3e-54 179.4 11.1 2.3e-10 39.9 0.0 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 ESA16251.1 - 3.2e-12 46.5 0.2 0.0012 18.5 0.0 3.8 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 ESA16251.1 - 3e-05 22.0 0.3 0.0066 14.3 0.0 2.7 2 1 1 3 3 3 2 IKI3 family Coatomer_WDAD PF04053.9 ESA16251.1 - 4.8e-05 22.3 0.7 0.22 10.2 0.0 2.9 1 1 0 2 2 2 2 Coatomer WD associated region Apc4_WD40 PF12894.2 ESA16251.1 - 0.00054 19.4 0.0 1.7 8.2 0.0 3.6 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.11 ESA16251.1 - 0.00055 18.3 0.0 0.0074 14.6 0.0 2.5 1 1 2 3 3 3 1 Cytochrome D1 heme domain PD40 PF07676.7 ESA16251.1 - 0.00094 18.7 0.3 1.2 8.8 0.1 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Lactonase PF10282.4 ESA16251.1 - 0.019 14.0 0.0 1.4 7.9 0.0 2.9 1 1 2 3 3 3 0 Lactonase, 7-bladed beta-propeller TFIIIC_delta PF12657.2 ESA16251.1 - 0.022 14.4 2.9 2.1 8.0 0.1 3.2 2 1 0 3 3 3 0 Transcription factor IIIC subunit delta N-term Nucleoporin_N PF08801.6 ESA16251.1 - 0.029 13.1 1.3 7.3 5.2 0.0 3.4 2 2 1 3 3 3 0 Nup133 N terminal like DUF3312 PF11768.3 ESA16251.1 - 0.12 10.5 0.1 5.7 5.0 0.0 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3312) PDT PF00800.13 ESA16252.1 - 5.9e-63 211.6 0.0 8.6e-63 211.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase CM_2 PF01817.16 ESA16252.1 - 3e-16 59.2 0.3 7.1e-16 58.0 0.2 1.6 1 0 0 1 1 1 1 Chorismate mutase type II ACT PF01842.20 ESA16252.1 - 2.2e-08 33.3 0.0 5.6e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 ACT domain Med11 PF10280.4 ESA16252.1 - 0.083 12.9 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Mediator complex protein DUF837 PF05769.6 ESA16253.1 - 0.0014 18.1 1.5 0.0014 18.1 1.1 2.3 3 1 0 3 3 3 1 Protein of unknown function (DUF837) Geminin PF07412.7 ESA16253.1 - 0.0038 16.9 1.7 0.0038 16.9 1.2 2.1 2 0 0 2 2 2 1 Geminin DUF4163 PF13739.1 ESA16253.1 - 0.049 14.4 1.8 0.049 14.4 1.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4163) AHSP PF09236.5 ESA16253.1 - 0.72 10.0 4.0 1.8 8.8 0.4 2.8 2 1 0 2 2 2 0 Alpha-haemoglobin stabilising protein TSC22 PF01166.13 ESA16253.1 - 3 7.8 8.0 1.3 9.0 0.2 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family tRNA_bind_2 PF13725.1 ESA16255.1 - 0.0066 16.5 0.1 0.018 15.1 0.1 1.8 1 0 0 1 1 1 1 Possible tRNA binding domain CCDC155 PF14662.1 ESA16255.1 - 0.27 10.8 45.8 0.034 13.7 22.0 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Reo_sigmaC PF04582.7 ESA16255.1 - 4 6.5 9.1 9 5.3 0.4 2.2 2 0 0 2 2 2 0 Reovirus sigma C capsid protein GAGA_bind PF06217.7 ESA16255.1 - 9.5 6.0 26.0 48 3.7 16.5 2.5 1 1 0 1 1 1 0 GAGA binding protein-like family UPF0233 PF06781.7 ESA16257.1 - 0.017 14.7 0.1 0.025 14.2 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0233) Endonuc-MspI PF09208.5 ESA16257.1 - 0.047 12.7 0.6 0.058 12.4 0.4 1.1 1 0 0 1 1 1 0 Restriction endonuclease MspI Xpo1 PF08389.7 ESA16257.1 - 0.18 11.6 1.5 0.29 11.0 1.0 1.5 1 1 0 1 1 1 0 Exportin 1-like protein YkyA PF10368.4 ESA16258.1 - 0.049 12.9 0.5 0.066 12.5 0.1 1.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Zip PF02535.17 ESA16259.1 - 1.3 7.9 3.7 1.6 7.6 2.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter HMG_box PF00505.14 ESA16260.1 - 6.5e-08 32.7 2.9 6.5e-08 32.7 2.0 2.3 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA16260.1 - 0.00018 21.8 4.9 0.00018 21.8 3.4 2.0 1 1 1 2 2 2 1 HMG-box domain DUF1014 PF06244.7 ESA16260.1 - 0.00076 19.6 5.4 0.00087 19.4 0.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1014) YABBY PF04690.8 ESA16260.1 - 0.00096 19.4 2.3 0.00096 19.4 1.6 1.8 1 1 1 2 2 2 1 YABBY protein Radial_spoke PF04712.7 ESA16260.1 - 0.033 12.9 3.6 0.042 12.6 2.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein BTB PF00651.26 ESA16261.1 - 4.9e-13 49.0 0.1 9.4e-13 48.1 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16261.1 - 1.7e-11 44.2 0.5 6.3e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA16261.1 - 9.3e-06 25.4 1.1 0.00034 20.4 0.0 3.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF1219 PF06755.7 ESA16261.1 - 0.11 11.9 0.2 16 5.0 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1219) NdhL PF10716.4 ESA16261.1 - 0.12 12.1 0.9 0.26 11.0 0.6 1.5 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit MIR PF02815.14 ESA16267.1 - 4.2e-18 65.5 0.1 8e-18 64.6 0.1 1.4 1 0 0 1 1 1 1 MIR domain Ins145_P3_rec PF08709.6 ESA16267.1 - 0.00087 18.3 0.1 0.052 12.5 0.0 2.2 2 0 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor SPX PF03105.14 ESA16268.1 - 4.4e-24 85.7 12.9 6.5e-24 85.1 8.9 1.2 1 0 0 1 1 1 1 SPX domain zf-RING_2 PF13639.1 ESA16268.1 - 1.4e-06 28.0 14.6 2.7e-06 27.0 10.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 ESA16268.1 - 1.6e-06 27.8 13.0 3.9e-06 26.6 9.0 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 ESA16268.1 - 5e-06 26.4 16.0 9.7e-06 25.5 11.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA16268.1 - 1.3e-05 24.8 14.3 0.00012 21.6 9.9 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA16268.1 - 0.00087 18.8 13.6 0.0016 18.0 9.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA16268.1 - 0.0076 15.9 7.2 0.0076 15.9 5.0 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.1 ESA16268.1 - 0.015 14.9 15.8 0.028 14.1 10.0 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cys_rich_CPCC PF14206.1 ESA16268.1 - 0.84 9.2 5.5 0.97 9.0 0.5 2.5 2 0 0 2 2 2 0 Cysteine-rich CPCC zf-RING_4 PF14570.1 ESA16268.1 - 3 7.5 12.3 1.3 8.6 5.7 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain AAA_2 PF07724.9 ESA16270.1 - 0.039 13.8 0.1 0.041 13.7 0.1 1.2 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF177 PF02620.12 ESA16270.1 - 0.067 13.2 0.2 0.081 12.9 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, COG1399 Pox_VP8_L4R PF04498.7 ESA16272.1 - 0.036 13.3 0.0 0.042 13.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R Nuc_sug_transp PF04142.10 ESA16273.1 - 0.041 12.9 0.0 0.046 12.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-sugar transporter TatD_DNase PF01026.16 ESA16274.1 - 0.049 12.8 0.0 0.091 11.9 0.0 1.4 1 0 0 1 1 1 0 TatD related DNase DUF2011 PF09428.5 ESA16276.1 - 0.0032 17.3 1.5 0.0036 17.1 1.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) DUF896 PF05979.7 ESA16276.1 - 0.086 12.4 2.4 0.091 12.3 0.9 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) Pkinase PF00069.20 ESA16277.1 - 4.3e-27 94.8 0.1 1.3e-26 93.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16277.1 - 1e-25 90.2 0.0 1.7e-25 89.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3737 PF12541.3 ESA16278.1 - 0.014 14.4 1.0 0.017 14.0 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3737) Beta_helix PF13229.1 ESA16278.1 - 0.19 11.4 2.7 0.29 10.8 1.8 1.3 1 0 0 1 1 1 0 Right handed beta helix region Glyco_hydro_28 PF00295.12 ESA16278.1 - 0.21 10.4 3.9 0.99 8.2 2.7 1.8 1 1 0 1 1 1 0 Glycosyl hydrolases family 28 CDtoxinA PF03498.9 ESA16278.1 - 0.45 9.8 7.5 0.58 9.5 5.2 1.2 1 0 0 1 1 1 0 Cytolethal distending toxin A/C family DUF4499 PF14934.1 ESA16279.1 - 0.024 14.5 1.9 0.034 14.0 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4499) Caps_synth_CapC PF14102.1 ESA16279.1 - 0.16 12.0 4.1 0.21 11.7 2.9 1.2 1 0 0 1 1 1 0 Capsule biosynthesis CapC FixQ PF05545.6 ESA16279.1 - 1.6 8.4 5.0 0.97 9.1 0.5 2.5 2 1 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF2470 PF10615.4 ESA16280.1 - 1.1e-13 51.1 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pro_Al_protease PF02983.9 ESA16280.1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Alpha-lytic protease prodomain GCFC PF07842.7 ESA16281.1 - 1.1e-66 225.0 10.9 1.5e-66 224.5 7.5 1.2 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.18 ESA16281.1 - 3.6e-14 52.2 1.7 7.2e-14 51.3 1.2 1.5 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.3 ESA16281.1 - 9.6e-08 32.0 5.3 4.5e-07 29.9 3.7 2.2 1 1 0 1 1 1 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.2 ESA16281.1 - 7.5e-05 22.5 2.0 0.00025 20.8 0.1 2.7 2 0 0 2 2 2 1 DExH-box splicing factor binding site Mitoc_L55 PF09776.4 ESA16282.1 - 0.0078 15.7 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 DUF3960 PF13142.1 ESA16282.1 - 0.21 11.3 1.4 0.67 9.7 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3960) OppC_N PF12911.2 ESA16284.1 - 6.4 6.2 6.2 3 7.2 0.8 2.2 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Sel1 PF08238.7 ESA16287.1 - 3.3e-125 405.7 40.0 4.8e-11 42.9 0.0 13.1 13 0 0 13 13 13 13 Sel1 repeat TPR_16 PF13432.1 ESA16287.1 - 1.6e-06 28.5 0.1 7.7 7.3 0.0 6.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16287.1 - 0.0078 16.1 13.2 8.4 6.4 0.0 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat 23S_rRNA_IVP PF05635.6 ESA16287.1 - 0.19 11.6 2.1 21 5.0 0.0 3.9 4 1 1 5 5 5 0 23S rRNA-intervening sequence protein Sel1 PF08238.7 ESA16289.1 - 1.3e-20 73.3 0.1 2.2e-09 37.6 0.2 2.1 2 0 0 2 2 2 2 Sel1 repeat TPR_1 PF00515.23 ESA16289.1 - 0.034 13.7 5.7 0.28 10.8 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16289.1 - 0.071 13.0 0.3 0.13 12.1 0.2 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16289.1 - 0.093 12.6 2.6 0.92 9.5 0.1 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA16289.1 - 0.11 12.3 0.2 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain MMtag PF10159.4 ESA16289.1 - 0.37 10.8 2.1 6.7 6.8 1.5 2.0 1 1 1 2 2 2 0 Kinase phosphorylation protein TPR_8 PF13181.1 ESA16289.1 - 0.55 10.1 0.2 0.55 10.1 0.1 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ATX_III PF08098.6 ESA16289.1 - 5.5 6.9 6.2 0.55 10.0 1.2 1.7 2 0 0 2 2 2 0 Anemonia sulcata toxin III family Sel1 PF08238.7 ESA16290.1 - 1.6e-13 50.8 0.6 6.4e-09 36.1 0.1 3.7 3 0 0 3 3 3 2 Sel1 repeat Sel1 PF08238.7 ESA16291.1 - 3.6e-30 103.7 8.3 1e-08 35.5 0.2 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_16 PF13432.1 ESA16291.1 - 0.0018 18.9 0.0 7.3 7.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat SLT PF01464.15 ESA16291.1 - 0.024 14.1 4.0 0.26 10.8 0.4 2.3 1 1 1 2 2 2 0 Transglycosylase SLT domain TPR_2 PF07719.12 ESA16291.1 - 0.034 14.0 2.9 0.98 9.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16291.1 - 0.041 13.4 5.8 0.41 10.3 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA16291.1 - 0.054 13.4 0.1 1.1 9.2 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16291.1 - 0.15 12.0 1.5 2 8.4 0.0 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16291.1 - 0.18 11.6 3.8 0.72 9.7 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat MMtag PF10159.4 ESA16291.1 - 0.36 10.9 7.6 3.2 7.8 1.9 3.1 1 1 1 2 2 2 0 Kinase phosphorylation protein TPR_11 PF13414.1 ESA16291.1 - 0.48 10.1 5.4 9.8 5.9 0.2 3.0 1 1 0 2 2 2 0 TPR repeat Sel1 PF08238.7 ESA16292.1 - 7.4e-100 325.2 25.8 6.1e-11 42.5 0.0 9.1 9 0 0 9 9 9 9 Sel1 repeat 23S_rRNA_IVP PF05635.6 ESA16292.1 - 0.0054 16.6 2.0 32 4.4 0.0 4.3 3 1 2 5 5 5 1 23S rRNA-intervening sequence protein IR1-M PF12185.3 ESA16292.1 - 0.64 9.7 9.2 73 3.1 0.0 6.1 7 0 0 7 7 7 0 Nup358/RanBP2 E3 ligase domain SLT PF01464.15 ESA16292.1 - 1.7 8.1 14.7 3.7 7.0 0.4 4.7 3 1 1 5 5 5 0 Transglycosylase SLT domain KH_5 PF13184.1 ESA16293.1 - 0.096 12.4 0.1 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 NusA-like KH domain TSC22 PF01166.13 ESA16294.1 - 0.03 14.3 0.2 0.072 13.0 0.1 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family FlaC_arch PF05377.6 ESA16294.1 - 0.043 13.7 1.3 0.093 12.6 0.3 2.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.7 ESA16294.1 - 0.051 13.3 3.0 0.072 12.9 2.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nup54 PF13874.1 ESA16294.1 - 0.085 12.5 1.0 0.18 11.4 0.7 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 RNase_H PF00075.19 ESA16294.1 - 0.088 13.1 0.1 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 RNase H DDE_1 PF03184.14 ESA16295.1 - 5.4e-09 35.5 0.0 7.5e-06 25.2 0.0 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease Laminin_II PF06009.7 ESA16296.1 - 0.081 12.6 0.2 0.2 11.4 0.2 1.6 1 0 0 1 1 1 0 Laminin Domain II NPV_P10 PF05531.7 ESA16296.1 - 0.11 12.8 1.1 0.37 11.0 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-RING_2 PF13639.1 ESA16296.1 - 0.86 9.4 7.5 4.8 7.0 3.8 2.6 2 1 0 2 2 2 0 Ring finger domain LIM PF00412.17 ESA16296.1 - 1.7 8.7 9.6 0.29 11.2 3.5 2.2 2 0 0 2 2 2 0 LIM domain HEAT PF02985.17 ESA16297.1 - 4.7e-26 88.4 7.0 0.0002 21.1 0.0 10.8 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.1 ESA16297.1 - 5.3e-24 84.3 0.1 1.4e-08 34.9 0.1 7.0 5 2 3 8 8 8 5 HEAT repeats HEAT_EZ PF13513.1 ESA16297.1 - 6.2e-24 83.8 6.5 5e-06 26.8 0.1 10.8 9 1 2 11 11 11 5 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ESA16297.1 - 3.3e-16 59.4 3.3 9e-05 22.7 0.0 8.6 7 1 2 10 10 10 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 ESA16297.1 - 5.9e-10 38.8 0.0 0.012 14.9 0.0 6.8 5 3 2 7 7 7 2 CLASP N terminal Cnd1 PF12717.2 ESA16297.1 - 2.9e-07 30.5 6.4 0.36 10.6 0.0 5.8 5 2 2 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.3 ESA16297.1 - 1.2e-06 28.3 0.0 0.63 10.0 0.0 6.0 5 1 1 6 6 6 2 Rix1 complex component involved in 60S ribosome maturation IBN_N PF03810.14 ESA16297.1 - 1.6e-05 24.7 1.8 1.6e-05 24.7 1.3 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain MMS19_C PF12460.3 ESA16297.1 - 0.00081 18.2 8.2 0.041 12.5 1.0 5.6 4 2 0 4 4 4 1 RNAPII transcription regulator C-terminal DUF3385 PF11865.3 ESA16297.1 - 0.014 15.2 7.6 0.27 11.1 0.0 5.3 6 1 0 6 6 6 0 Domain of unknown function (DUF3385) RNA_pol_Rpc82 PF05645.8 ESA16299.1 - 0.0043 16.6 0.5 0.026 14.0 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 BAR PF03114.13 ESA16302.1 - 5.1e-22 78.5 10.5 5.1e-22 78.5 7.3 2.3 3 0 0 3 3 3 1 BAR domain RhoGEF PF00621.15 ESA16302.1 - 1.5e-16 60.7 0.1 1.5e-16 60.7 0.0 3.1 2 1 1 3 3 3 1 RhoGEF domain SH3_1 PF00018.23 ESA16302.1 - 2.8e-06 26.5 1.6 2.8e-06 26.5 1.1 2.2 3 0 0 3 3 3 1 SH3 domain SH3_2 PF07653.12 ESA16302.1 - 7.7e-05 22.1 0.1 0.00018 20.9 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF2365 PF10157.4 ESA16302.1 - 0.016 15.0 0.3 0.039 13.8 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) SH3_9 PF14604.1 ESA16302.1 - 0.019 14.5 0.1 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain KIP1 PF07765.7 ESA16302.1 - 3.9 7.3 9.2 2.3 8.1 0.6 3.9 3 1 1 4 4 4 0 KIP1-like protein Sec10 PF07393.6 ESA16303.1 - 9.8e-132 440.5 15.4 1.2e-131 440.2 10.6 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.2 ESA16303.1 - 1.2e-08 34.4 0.5 3.2e-08 33.1 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA16303.1 - 1.5e-07 30.9 0.1 3.5e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain FDX-ACB PF03147.9 ESA16303.1 - 0.013 15.6 0.8 0.74 10.0 0.0 3.2 3 0 0 3 3 3 0 Ferredoxin-fold anticodon binding domain Peptidase_C2 PF00648.16 ESA16304.1 - 4.3e-34 117.8 0.0 6.7e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 ESA16304.1 - 1.5e-23 83.1 0.1 2.8e-15 56.2 0.0 2.9 2 1 0 2 2 2 2 Calpain large subunit, domain III DUF1180 PF06679.7 ESA16305.1 - 0.066 13.0 1.2 0.073 12.9 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3586 PF12131.3 ESA16305.1 - 0.088 12.8 5.2 0.12 12.4 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3586) AflR PF08493.5 ESA16305.1 - 3.2 6.6 5.1 3.6 6.5 3.6 1.1 1 0 0 1 1 1 0 Aflatoxin regulatory protein Somatomedin_B PF01033.12 ESA16306.1 - 4.8 7.2 9.9 5 7.1 1.0 2.1 1 1 1 2 2 2 0 Somatomedin B domain PARP PF00644.15 ESA16307.1 - 6.6e-06 25.6 0.0 8.6e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Dynamin_M PF01031.15 ESA16308.1 - 9e-107 356.2 4.5 2.4e-106 354.8 0.0 2.2 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.18 ESA16308.1 - 1.4e-56 190.8 1.6 1.6e-56 190.7 0.1 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 ESA16308.1 - 1.4e-29 101.8 7.9 3.8e-29 100.4 5.5 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 ESA16308.1 - 0.00021 21.2 2.4 0.011 15.6 0.6 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 ESA16308.1 - 0.029 14.8 0.0 0.076 13.5 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein UPF0139 PF03669.8 ESA16309.1 - 3.4e-18 65.0 0.0 4e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF4190 PF13828.1 ESA16309.1 - 0.017 14.6 0.6 0.047 13.2 0.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4190) Ribosomal_L11_N PF03946.9 ESA16310.1 - 2.4e-18 65.3 0.1 3.7e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 ESA16310.1 - 1.9e-14 53.5 0.1 3.3e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain AAR2 PF05282.6 ESA16311.1 - 1.1e-79 267.9 5.9 3.6e-79 266.3 4.1 1.6 1 1 0 1 1 1 1 AAR2 protein UEV PF05743.8 ESA16312.1 - 7.8e-37 125.6 0.2 1.4e-36 124.8 0.1 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.5 ESA16312.1 - 6.4e-25 86.5 0.2 1.2e-24 85.6 0.1 1.5 1 0 0 1 1 1 1 Vps23 core domain DUF342 PF03961.8 ESA16312.1 - 0.031 12.6 3.1 0.045 12.1 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) UQ_con PF00179.21 ESA16312.1 - 0.035 13.5 1.7 0.064 12.6 0.7 1.8 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme DUF948 PF06103.6 ESA16312.1 - 0.19 11.6 0.6 0.41 10.5 0.4 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Ribosomal_L37 PF08561.5 ESA16313.1 - 1.4e-23 82.2 1.2 2.1e-23 81.6 0.8 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Statherin PF03875.8 ESA16314.1 - 2 8.3 12.1 0.51 10.2 3.7 2.4 2 0 0 2 2 2 0 Statherin DUF1421 PF07223.6 ESA16314.1 - 7.7 6.1 15.6 8.5 6.0 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1421) PAM2 PF07145.10 ESA16315.1 - 0.22 11.0 5.8 1.7 8.3 0.9 2.5 2 0 0 2 2 2 0 Ataxin-2 C-terminal region MIP-T3 PF10243.4 ESA16315.1 - 0.52 8.7 35.7 0.57 8.5 24.7 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF2201_N PF13203.1 ESA16315.1 - 4.5 6.3 17.8 5.5 6.0 12.4 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain Ndc1_Nup PF09531.5 ESA16315.1 - 5.2 5.3 12.8 5.7 5.2 8.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GET2 PF08690.5 ESA16315.1 - 9.8 5.3 10.1 12 5.0 7.0 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 LsmAD PF06741.8 ESA16316.1 - 5.6e-25 87.2 2.6 1.5e-24 85.8 1.8 1.8 1 0 0 1 1 1 1 LsmAD domain DUF3439 PF11921.3 ESA16316.1 - 0.44 10.2 9.3 0.87 9.3 6.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.12 ESA16316.1 - 1.1 9.0 18.1 1.8 8.3 12.6 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein RRM_1 PF00076.17 ESA16317.1 - 1.2e-20 72.8 0.0 1.8e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA16317.1 - 3.9e-16 58.7 0.0 5.3e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA16317.1 - 2.9e-11 43.0 0.0 4.4e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dymeclin PF09742.4 ESA16318.1 - 2.5e-116 389.4 10.3 2.9e-116 389.2 7.1 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.2 ESA16318.1 - 0.0044 14.7 17.7 0.0076 13.9 6.3 2.6 2 1 0 2 2 2 2 High-temperature-induced dauer-formation protein Aa_trans PF01490.13 ESA16320.1 - 3.5e-86 289.2 32.0 4.3e-86 288.9 22.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 ESA16320.1 - 6.5e-07 28.4 17.5 6.5e-07 28.4 12.1 1.9 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family CIAPIN1 PF05093.8 ESA16321.1 - 1.7e-23 82.5 15.1 9.2e-18 64.1 3.4 2.4 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Hex_IIIa PF02455.11 ESA16321.1 - 0.051 12.2 0.0 0.078 11.6 0.0 1.2 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Arm PF00514.18 ESA16322.1 - 2.9e-09 36.4 0.1 9.8e-05 22.0 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 ESA16322.1 - 3.6e-05 23.0 0.5 5.2e-05 22.4 0.3 1.2 1 0 0 1 1 1 1 Armadillo-like HEAT_2 PF13646.1 ESA16322.1 - 0.01 16.0 0.0 0.2 11.9 0.0 2.4 1 1 0 1 1 1 0 HEAT repeats WAPL PF07814.8 ESA16322.1 - 0.011 14.4 0.2 0.014 14.1 0.2 1.2 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin Ndr PF03096.9 ESA16322.1 - 0.033 12.6 0.4 0.044 12.2 0.3 1.2 1 0 0 1 1 1 0 Ndr family MMS19_C PF12460.3 ESA16322.1 - 0.16 10.7 4.9 0.06 12.0 1.2 1.9 2 1 0 2 2 2 0 RNAPII transcription regulator C-terminal BTB PF00651.26 ESA16324.1 - 2.6e-20 72.4 0.1 5.7e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain MATH PF00917.21 ESA16324.1 - 0.0072 16.5 0.1 0.023 14.9 0.0 1.9 1 1 0 1 1 1 1 MATH domain DUF4379 PF14311.1 ESA16326.1 - 0.0087 15.8 4.5 0.015 15.0 3.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) GATA PF00320.22 ESA16327.1 - 4.5e-05 22.6 0.6 8.4e-05 21.8 0.4 1.5 1 0 0 1 1 1 1 GATA zinc finger FAM220 PF15487.1 ESA16327.1 - 0.12 11.7 3.2 0.16 11.3 2.2 1.2 1 0 0 1 1 1 0 FAM220 family CAF-1_p150 PF11600.3 ESA16327.1 - 0.88 8.9 4.5 1 8.7 3.1 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal GATA PF00320.22 ESA16328.1 - 2e-16 58.9 4.6 2.7e-16 58.6 3.2 1.2 1 0 0 1 1 1 1 GATA zinc finger OrfB_Zn_ribbon PF07282.6 ESA16328.1 - 0.022 14.4 0.4 0.027 14.1 0.3 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain eIF-5_eIF-2B PF01873.12 ESA16328.1 - 0.03 13.9 0.5 0.04 13.5 0.4 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 RRN7 PF11781.3 ESA16328.1 - 0.031 13.7 0.7 0.055 12.9 0.5 1.5 1 1 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn-ribbon_8 PF09723.5 ESA16328.1 - 0.035 14.0 0.3 0.051 13.5 0.2 1.3 1 0 0 1 1 1 0 Zinc ribbon domain DZR PF12773.2 ESA16328.1 - 0.048 13.4 3.1 0.17 11.7 2.1 1.7 1 1 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.7 ESA16328.1 - 0.056 12.7 0.1 0.083 12.2 0.1 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding ArfGap PF01412.13 ESA16328.1 - 0.074 12.8 0.1 0.074 12.8 0.1 1.2 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf zf-B_box PF00643.19 ESA16328.1 - 0.084 12.7 0.8 0.26 11.1 0.6 1.8 1 1 0 1 1 1 0 B-box zinc finger zf-ribbon_3 PF13248.1 ESA16328.1 - 0.65 9.2 5.2 4.4 6.6 3.6 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA16328.1 - 1.1 8.7 5.7 6 6.5 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GSu_C4xC__C2xCH PF09698.5 ESA16328.1 - 6.8 6.9 6.2 16 5.7 4.3 1.6 1 1 0 1 1 1 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) SelR PF01641.13 ESA16329.1 - 1.5e-52 176.5 0.1 1.7e-52 176.3 0.1 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.9 ESA16329.1 - 0.036 14.0 0.4 0.11 12.5 0.3 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly GFA PF04828.9 ESA16329.1 - 0.046 13.6 0.3 2.2 8.2 0.0 2.2 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Tnp_zf-ribbon_2 PF13842.1 ESA16329.1 - 0.05 14.0 0.1 4.6 7.7 0.0 2.3 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DUF678 PF05077.7 ESA16329.1 - 0.061 13.3 0.4 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) ZF-HD_dimer PF04770.7 ESA16329.1 - 0.068 13.2 0.7 2.2 8.3 0.0 2.3 2 0 0 2 2 2 0 ZF-HD protein dimerisation region DZR PF12773.2 ESA16329.1 - 0.14 12.0 1.6 0.66 9.8 1.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon DNA_RNApol_7kD PF03604.8 ESA16329.1 - 0.4 10.1 3.4 13 5.3 0.2 3.0 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Zn_Tnp_IS1595 PF12760.2 ESA16329.1 - 0.83 9.5 3.0 4.5 7.1 0.0 2.4 2 1 0 2 2 2 0 Transposase zinc-ribbon domain DnaJ PF00226.26 ESA16330.1 - 2.2e-18 65.7 3.0 2.3e-18 65.7 1.2 1.7 2 0 0 2 2 2 1 DnaJ domain ESSS PF10183.4 ESA16330.1 - 0.15 12.4 0.9 0.28 11.5 0.3 1.8 2 1 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) MMR_HSR1 PF01926.18 ESA16331.1 - 4.5e-18 65.3 0.4 5.1e-15 55.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA16331.1 - 1.7e-06 27.3 0.2 0.00016 21.0 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 ESA16331.1 - 0.00014 21.0 0.0 0.0003 20.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA16331.1 - 0.0013 17.8 1.4 0.0016 17.5 0.0 1.8 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.18 ESA16331.1 - 0.014 15.2 0.3 0.014 15.2 0.2 3.3 3 1 0 3 3 3 0 Dynamin family Miro PF08477.8 ESA16331.1 - 0.026 15.0 0.3 0.1 13.0 0.0 2.2 2 1 0 2 2 2 0 Miro-like protein cobW PF02492.14 ESA16331.1 - 0.036 13.5 0.3 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNase_HII PF01351.13 ESA16332.1 - 1.9e-39 135.3 0.0 2.4e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII DUF2677 PF10838.3 ESA16334.1 - 0.012 15.3 0.1 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) NdhM PF10664.4 ESA16334.1 - 0.082 12.8 0.2 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M Septin PF00735.13 ESA16335.1 - 3.2e-81 272.4 0.1 3.2e-81 272.4 0.1 1.4 2 0 0 2 2 2 1 Septin Pro_3_hydrox_C PF05373.6 ESA16335.1 - 0.029 14.3 1.3 0.083 12.9 0.9 1.9 1 1 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal YbjQ_1 PF01906.12 ESA16335.1 - 0.14 12.6 0.2 0.28 11.6 0.2 1.4 1 0 0 1 1 1 0 Putative heavy-metal-binding BRCT PF00533.21 ESA16338.1 - 5.5e-10 39.2 0.1 5.8e-09 35.9 0.0 2.5 2 1 1 3 3 3 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 ESA16338.1 - 2.3e-09 36.9 0.0 4.1e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.16 ESA16338.1 - 4.4e-05 23.5 0.0 0.00013 22.0 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.3 ESA16338.1 - 0.00075 19.1 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) LSM PF01423.17 ESA16339.1 - 1.8e-14 53.0 0.3 2.3e-14 52.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 ESA16339.1 - 4.4e-06 26.5 0.0 5.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain bZIP_1 PF00170.16 ESA16340.1 - 0.00011 22.0 10.8 0.051 13.5 4.1 2.2 2 0 0 2 2 2 2 bZIP transcription factor CENP-F_leu_zip PF10473.4 ESA16340.1 - 0.00027 20.8 13.9 0.0074 16.1 9.6 2.0 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 ESA16340.1 - 0.00053 19.7 5.3 0.00053 19.7 3.6 1.3 1 1 0 1 1 1 1 TPR/MLP1/MLP2-like protein Herpes_BLRF2 PF05812.7 ESA16340.1 - 0.00093 18.9 6.1 0.17 11.6 0.2 2.2 1 1 1 2 2 2 2 Herpesvirus BLRF2 protein Caldesmon PF02029.10 ESA16340.1 - 0.0022 16.4 10.3 0.0026 16.2 7.1 1.0 1 0 0 1 1 1 1 Caldesmon Spc7 PF08317.6 ESA16340.1 - 0.0023 16.6 6.2 0.0026 16.5 4.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Shugoshin_N PF07558.6 ESA16340.1 - 0.0033 17.1 5.2 0.18 11.5 0.4 2.6 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region DivIC PF04977.10 ESA16340.1 - 0.0046 16.4 9.0 0.13 11.7 2.3 2.3 1 1 1 2 2 2 2 Septum formation initiator ACCA PF03255.9 ESA16340.1 - 0.0093 15.5 1.4 0.013 15.0 0.9 1.3 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Uds1 PF15456.1 ESA16340.1 - 0.011 15.7 9.6 0.019 14.9 6.6 1.4 1 1 0 1 1 1 0 Up-regulated During Septation NYD-SP28_assoc PF14775.1 ESA16340.1 - 0.011 15.3 2.2 0.35 10.6 0.2 2.3 2 0 0 2 2 2 0 Sperm tail C-terminal domain Ax_dynein_light PF10211.4 ESA16340.1 - 0.014 15.2 7.3 0.014 15.2 5.1 1.8 1 1 1 2 2 2 0 Axonemal dynein light chain Nup54 PF13874.1 ESA16340.1 - 0.016 14.8 4.9 0.22 11.1 2.0 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 IncA PF04156.9 ESA16340.1 - 0.016 14.7 9.9 0.022 14.3 6.9 1.1 1 0 0 1 1 1 0 IncA protein CALCOCO1 PF07888.6 ESA16340.1 - 0.02 13.2 7.5 0.022 13.0 5.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.1 ESA16340.1 - 0.021 14.0 9.0 0.025 13.7 6.3 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Mnd1 PF03962.10 ESA16340.1 - 0.025 14.2 7.1 0.029 14.0 4.9 1.1 1 0 0 1 1 1 0 Mnd1 family TBPIP PF07106.8 ESA16340.1 - 0.033 13.7 7.0 0.059 12.9 4.8 1.5 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4201 PF13870.1 ESA16340.1 - 0.035 13.5 8.8 0.044 13.2 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) TMCO5 PF14992.1 ESA16340.1 - 0.035 13.2 6.4 0.041 13.0 4.4 1.1 1 0 0 1 1 1 0 TMCO5 family TMF_DNA_bd PF12329.3 ESA16340.1 - 0.036 13.8 7.1 1 9.2 0.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding bZIP_2 PF07716.10 ESA16340.1 - 0.041 13.6 12.0 1.3 8.9 3.4 2.6 1 1 1 3 3 3 0 Basic region leucine zipper AKNA PF12443.3 ESA16340.1 - 0.042 13.8 2.6 1.1 9.3 0.4 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor Leu_zip PF15294.1 ESA16340.1 - 0.044 12.8 9.1 0.89 8.6 2.8 2.1 1 1 1 2 2 2 0 Leucine zipper DUF2802 PF10975.3 ESA16340.1 - 0.045 13.4 2.3 3.2 7.5 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2802) MCC-bdg_PDZ PF10506.4 ESA16340.1 - 0.065 13.0 0.3 0.065 13.0 0.2 2.3 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF972 PF06156.8 ESA16340.1 - 0.068 13.5 8.2 0.41 11.0 4.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Tho2 PF11262.3 ESA16340.1 - 0.07 12.1 3.5 0.085 11.8 2.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF724 PF05266.9 ESA16340.1 - 0.071 12.7 6.7 0.096 12.3 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) IFP_35_N PF07334.8 ESA16340.1 - 0.08 12.9 5.7 3 7.8 0.4 2.6 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus BBP1_C PF15272.1 ESA16340.1 - 0.087 12.3 7.5 0.099 12.1 5.2 1.1 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal Microtub_assoc PF07989.6 ESA16340.1 - 0.11 12.3 6.2 2.6 7.9 0.1 2.1 1 1 1 2 2 2 0 Microtubule associated Spc24 PF08286.6 ESA16340.1 - 0.11 12.2 8.7 1.1 8.9 3.9 2.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Seryl_tRNA_N PF02403.17 ESA16340.1 - 0.12 12.4 9.7 0.16 11.9 6.8 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF904 PF06005.7 ESA16340.1 - 0.12 12.6 9.9 9.7 6.5 6.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF904) CENP-H PF05837.7 ESA16340.1 - 0.13 12.4 6.8 0.23 11.6 4.7 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) AAA_13 PF13166.1 ESA16340.1 - 0.13 10.6 5.6 0.15 10.5 3.9 1.0 1 0 0 1 1 1 0 AAA domain DivIVA PF05103.8 ESA16340.1 - 0.15 12.1 9.2 0.98 9.4 1.3 2.0 1 1 1 2 2 2 0 DivIVA protein Mto2_bdg PF12808.2 ESA16340.1 - 0.16 12.1 10.7 3.8 7.6 3.6 2.5 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region CCDC155 PF14662.1 ESA16340.1 - 0.18 11.3 9.1 2.4 7.6 6.3 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 GrpE PF01025.14 ESA16340.1 - 0.18 11.3 10.6 3 7.3 7.4 1.9 1 1 0 1 1 1 0 GrpE Atg14 PF10186.4 ESA16340.1 - 0.18 10.6 6.5 0.21 10.4 4.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Dor1 PF04124.7 ESA16340.1 - 0.19 10.1 6.5 0.23 9.8 4.5 1.1 1 0 0 1 1 1 0 Dor1-like family Troponin PF00992.15 ESA16340.1 - 0.2 11.7 12.4 1.2 9.2 8.6 1.9 1 1 0 1 1 1 0 Troponin ADIP PF11559.3 ESA16340.1 - 0.21 11.4 10.3 1.9 8.3 4.7 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.2 ESA16340.1 - 0.21 11.4 10.8 0.27 11.0 7.5 1.1 1 0 0 1 1 1 0 Tropomyosin like Lipoprotein_6 PF01441.14 ESA16340.1 - 0.23 11.2 3.2 1.5 8.5 2.2 1.9 1 1 0 1 1 1 0 Lipoprotein Phage_GP20 PF06810.6 ESA16340.1 - 0.23 10.8 6.0 2.7 7.4 4.2 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 SlyX PF04102.7 ESA16340.1 - 0.25 11.7 6.0 2.8 8.3 0.9 2.2 1 1 1 2 2 2 0 SlyX DUF4200 PF13863.1 ESA16340.1 - 0.28 11.1 14.0 0.4 10.6 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1640 PF07798.6 ESA16340.1 - 0.33 10.9 7.1 0.62 10.0 4.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Tnp_P_element PF12017.3 ESA16340.1 - 0.34 10.1 5.7 0.44 9.7 0.4 2.0 1 1 1 2 2 2 0 Transposase protein DUF4398 PF14346.1 ESA16340.1 - 0.38 10.8 4.2 0.31 11.0 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4398) COG2 PF06148.6 ESA16340.1 - 0.39 10.5 4.6 0.67 9.8 3.1 1.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Striatin PF08232.7 ESA16340.1 - 0.72 10.1 10.1 2.4 8.4 6.0 2.0 1 1 1 2 2 2 0 Striatin family Fmp27_WPPW PF10359.4 ESA16340.1 - 0.8 8.0 7.6 0.87 7.9 5.3 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF342 PF03961.8 ESA16340.1 - 0.81 8.0 5.0 0.94 7.8 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TMF_TATA_bd PF12325.3 ESA16340.1 - 1.1 9.0 9.8 2.5 7.8 6.9 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FlaC_arch PF05377.6 ESA16340.1 - 1.1 9.2 6.3 2.4 8.1 0.4 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) APG6 PF04111.7 ESA16340.1 - 1.2 8.1 10.5 3.1 6.7 7.4 1.5 1 1 0 1 1 1 0 Autophagy protein Apg6 Prefoldin PF02996.12 ESA16340.1 - 1.3 8.6 5.8 11 5.6 0.2 2.2 1 1 0 2 2 2 0 Prefoldin subunit KIAA1430 PF13879.1 ESA16340.1 - 1.4 9.4 9.2 1.3 9.5 4.4 2.3 1 1 1 2 2 2 0 KIAA1430 homologue Cortex-I_coil PF09304.5 ESA16340.1 - 1.4 8.9 10.3 3.2 7.8 5.5 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil Phlebovirus_NSM PF07246.6 ESA16340.1 - 1.5 7.8 6.8 2.6 7.1 4.7 1.4 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF641 PF04859.7 ESA16340.1 - 2 8.1 5.9 2.2 8.0 0.7 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Prefoldin_2 PF01920.15 ESA16340.1 - 2.2 8.1 9.8 2.1 8.1 0.3 2.1 1 1 1 2 2 2 0 Prefoldin subunit CASP_C PF08172.7 ESA16340.1 - 2.4 7.1 9.6 3.7 6.4 0.1 2.1 1 1 1 2 2 2 0 CASP C terminal DUF4140 PF13600.1 ESA16340.1 - 2.5 8.5 8.0 6.8 7.2 2.6 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.14 ESA16340.1 - 2.6 5.7 7.0 3.1 5.5 4.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HAUS5 PF14817.1 ESA16340.1 - 9.8 4.5 11.6 9.5 4.6 3.0 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 5 DDE_1 PF03184.14 ESA16341.1 - 6.5e-13 48.3 0.7 1.4e-11 43.9 0.1 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease Flavi_M PF01004.14 ESA16341.1 - 0.079 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Flavivirus envelope glycoprotein M Pkinase_Tyr PF07714.12 ESA16342.1 - 1.3e-37 129.3 0.0 2e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16342.1 - 2.4e-31 108.8 0.0 5.5e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HHH_6 PF14579.1 ESA16344.1 - 0.016 15.2 0.0 0.02 14.9 0.0 1.1 1 0 0 1 1 1 0 Helix-hairpin-helix motif YhzD PF14120.1 ESA16344.1 - 0.02 14.8 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 YhzD-like protein HHH_3 PF12836.2 ESA16344.1 - 0.031 14.2 0.0 0.054 13.4 0.0 1.4 1 1 0 1 1 1 0 Helix-hairpin-helix motif PsbU PF06514.6 ESA16344.1 - 0.056 13.2 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Clathrin PF00637.15 ESA16344.1 - 0.09 12.3 0.7 0.12 11.9 0.5 1.4 1 1 0 1 1 1 0 Region in Clathrin and VPS ATP-synt_A PF00119.15 ESA16344.1 - 0.1 12.0 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 ATP synthase A chain F-box-like PF12937.2 ESA16346.1 - 0.004 16.8 0.0 0.021 14.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like DUF1542 PF07564.6 ESA16349.1 - 0.0047 16.9 3.9 0.0075 16.2 0.8 2.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA16349.1 - 0.075 12.8 0.6 0.087 12.6 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF972 PF06156.8 ESA16350.1 - 1.6e-05 25.1 2.5 4.3e-05 23.8 1.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF972) HALZ PF02183.13 ESA16350.1 - 0.0006 19.4 6.6 0.0006 19.4 4.6 2.2 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF4201 PF13870.1 ESA16350.1 - 0.0022 17.4 6.8 0.0046 16.4 4.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF904 PF06005.7 ESA16350.1 - 0.016 15.4 7.4 0.016 15.4 5.1 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF904) DivIC PF04977.10 ESA16350.1 - 0.022 14.2 8.6 0.022 14.2 6.0 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF1875 PF08961.5 ESA16350.1 - 0.053 12.8 1.7 0.1 11.9 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) Lebercilin PF15619.1 ESA16350.1 - 0.063 12.6 11.4 0.037 13.4 4.9 2.5 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF1640 PF07798.6 ESA16350.1 - 0.089 12.8 5.1 0.15 12.0 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) LicD PF04991.8 ESA16350.1 - 0.094 12.8 5.9 0.12 12.4 4.1 1.2 1 0 0 1 1 1 0 LicD family Tnp_P_element PF12017.3 ESA16350.1 - 0.29 10.3 7.6 0.46 9.6 4.3 1.8 1 1 1 2 2 2 0 Transposase protein bZIP_1 PF00170.16 ESA16350.1 - 0.37 10.7 8.1 0.38 10.7 4.4 2.0 1 1 0 1 1 1 0 bZIP transcription factor V_ATPase_I PF01496.14 ESA16350.1 - 0.41 8.4 3.1 0.44 8.3 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rootletin PF15035.1 ESA16350.1 - 1.2 9.0 10.9 0.58 10.1 5.5 1.8 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.6 ESA16350.1 - 2 8.2 12.7 0.33 10.7 6.0 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) IncA PF04156.9 ESA16350.1 - 3 7.4 9.1 4.9 6.7 6.3 1.3 1 0 0 1 1 1 0 IncA protein Bap31 PF05529.7 ESA16350.1 - 4.8 6.5 9.7 8.8 5.7 6.7 1.3 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Nup54 PF13874.1 ESA16351.1 - 1.9e-25 89.1 8.7 1.9e-25 89.1 6.1 1.6 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 ESA16351.1 - 1 9.6 31.5 1.8 8.7 21.9 1.4 1 0 0 1 1 1 0 Nucleoporin FG repeat region IncA PF04156.9 ESA16351.1 - 1.5 8.3 6.9 3.3 7.2 4.8 1.6 1 1 0 1 1 1 0 IncA protein S-AdoMet_synt_C PF02773.11 ESA16352.1 - 1.3e-71 238.7 0.2 2.1e-71 238.0 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 ESA16352.1 - 2.2e-47 159.8 0.0 4.3e-47 158.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 ESA16352.1 - 2.4e-42 143.2 0.1 4.8e-42 142.2 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain F-box-like PF12937.2 ESA16353.1 - 1.4e-07 31.1 0.1 3.3e-07 29.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA16353.1 - 5e-06 26.0 0.1 1.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 F-box domain MULE PF10551.4 ESA16355.1 - 0.078 13.1 0.6 0.9 9.7 0.1 2.3 1 1 1 2 2 2 0 MULE transposase domain p450 PF00067.17 ESA16356.1 - 1.8e-94 316.9 0.2 2.2e-94 316.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.11 ESA16357.1 - 1.5e-23 83.1 13.0 6.1e-23 81.0 9.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.8 ESA16357.1 - 0.0026 15.9 0.1 0.0029 15.7 0.1 1.0 1 0 0 1 1 1 1 Transmembrane secretion effector Sugar_tr PF00083.19 ESA16357.1 - 0.005 15.4 9.4 0.005 15.4 6.5 1.4 1 1 1 2 2 2 1 Sugar (and other) transporter DUF1275 PF06912.6 ESA16357.1 - 0.075 12.2 4.2 0.1 11.7 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1275) OATP PF03137.15 ESA16357.1 - 0.078 11.0 6.2 0.071 11.1 1.0 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Transgly_assoc PF04226.8 ESA16357.1 - 0.68 10.0 11.9 1.8 8.7 8.3 1.7 1 0 0 1 1 1 0 Transglycosylase associated protein DUF4131 PF13567.1 ESA16357.1 - 2.4 7.5 6.4 0.27 10.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Trs65 PF12735.2 ESA16358.1 - 4.5e-15 55.7 6.7 4.5e-15 55.7 4.7 1.8 1 1 1 2 2 2 1 TRAPP trafficking subunit Trs65 LMWPc PF01451.16 ESA16359.1 - 2.5e-29 102.3 0.0 2.8e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase ALMT PF11744.3 ESA16360.1 - 0.0026 16.4 0.2 0.0029 16.3 0.1 1.2 1 0 0 1 1 1 1 Aluminium activated malate transporter CAF1 PF04857.15 ESA16360.1 - 0.0063 15.8 0.0 0.015 14.6 0.0 2.0 1 1 0 1 1 1 1 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.15 ESA16360.1 - 0.0065 15.9 0.1 0.15 11.5 0.0 2.7 2 1 0 2 2 2 1 3'-5' exonuclease FUN14 PF04930.10 ESA16360.1 - 0.096 12.9 1.9 0.23 11.7 1.3 1.6 1 0 0 1 1 1 0 FUN14 family DUF4363 PF14276.1 ESA16360.1 - 0.28 10.8 4.9 0.53 10.0 3.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Peptidase_C12 PF01088.16 ESA16361.1 - 3.1e-72 242.2 0.0 7.9e-72 240.9 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 APG6 PF04111.7 ESA16361.1 - 0.035 13.1 3.6 0.05 12.6 2.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4463 PF14703.1 ESA16361.1 - 2 8.9 10.4 0.36 11.3 0.7 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4463) PPTA PF01239.17 ESA16362.1 - 1.1e-17 62.4 13.9 3e-06 26.3 1.5 5.2 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat PRP21_like_P PF12230.3 ESA16363.1 - 8.9e-59 198.7 13.0 8.9e-59 198.7 9.0 1.7 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 ESA16363.1 - 2.2e-41 139.2 5.6 2.1e-20 72.1 0.2 2.7 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.18 ESA16363.1 - 1.4e-10 40.3 0.0 3.6e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA16363.1 - 0.0075 15.9 2.1 0.028 14.1 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like OB_NTP_bind PF07717.11 ESA16364.1 - 1.2e-29 102.4 0.1 5.1e-29 100.4 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESA16364.1 - 1.5e-28 98.7 0.2 5.3e-28 97.0 0.1 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESA16364.1 - 2.3e-11 43.4 0.0 5.2e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA16364.1 - 3.1e-09 36.5 0.1 8e-09 35.2 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase SRP54 PF00448.17 ESA16364.1 - 1.9e-05 24.1 0.1 7.4e-05 22.2 0.1 1.9 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.1 ESA16364.1 - 0.00073 19.6 0.0 0.003 17.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESA16364.1 - 0.0041 16.9 0.0 0.86 9.3 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_23 PF13476.1 ESA16364.1 - 0.02 15.1 0.0 0.079 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 ESA16364.1 - 0.062 12.1 0.0 0.14 11.0 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.9 ESA16364.1 - 0.11 12.2 0.1 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain IF-2B PF01008.12 ESA16365.1 - 1.1e-73 247.6 0.1 1.9e-73 246.9 0.1 1.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family KxDL PF10241.4 ESA16366.1 - 3.6e-12 46.0 0.3 3.9e-12 45.9 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein Receptor_2B4 PF11465.3 ESA16366.1 - 0.096 12.6 0.3 0.11 12.4 0.2 1.1 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 Acyltransferase PF01553.16 ESA16367.1 - 2.6e-05 23.6 0.0 7.3e-05 22.2 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase zf-LYAR PF08790.6 ESA16368.1 - 2.3e-14 52.7 3.9 2.3e-14 52.7 2.7 2.0 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-TRAF PF02176.13 ESA16368.1 - 0.00092 19.5 3.3 0.0014 18.9 2.3 1.4 1 0 0 1 1 1 1 TRAF-type zinc finger IBR PF01485.16 ESA16368.1 - 0.021 14.6 6.0 0.021 14.6 4.2 1.5 2 0 0 2 2 2 0 IBR domain DUF3133 PF11331.3 ESA16368.1 - 0.048 13.2 1.4 0.048 13.2 1.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3133) Prok-RING_1 PF14446.1 ESA16368.1 - 0.47 10.2 4.3 2.5 7.8 3.0 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Opy2 PF09463.5 ESA16368.1 - 1.7 8.8 6.6 3.7 7.7 0.1 2.6 3 0 0 3 3 3 0 Opy2 protein C1_4 PF07975.7 ESA16368.1 - 2.5 8.1 7.5 2.3 8.2 4.0 1.9 1 1 1 2 2 2 0 TFIIH C1-like domain GCR1_C PF12550.3 ESA16370.1 - 1.1e-12 47.6 0.1 2.2e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes CAP59_mtransfer PF11735.3 ESA16371.1 - 6.3e-69 231.8 0.0 9.2e-69 231.3 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 E1_DerP2_DerF2 PF02221.10 ESA16372.1 - 2.4e-07 31.0 0.4 2.8e-07 30.8 0.3 1.2 1 0 0 1 1 1 1 ML domain Peptidase_M16_C PF05193.16 ESA16373.1 - 4.5e-06 26.4 0.1 5.3e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Pkinase_Tyr PF07714.12 ESA16375.1 - 9.7e-35 119.8 0.0 1.7e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16375.1 - 5.9e-34 117.3 0.1 5.9e-34 117.3 0.1 2.0 3 0 0 3 3 3 1 Protein kinase domain APH PF01636.18 ESA16375.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA16375.1 - 0.015 14.3 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tet_JBP PF12851.2 ESA16378.1 - 1.9e-11 43.5 0.0 3.3e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily Tox-REase-2 PF15646.1 ESA16378.1 - 0.0097 15.7 0.4 0.029 14.2 0.0 1.8 2 0 0 2 2 2 1 Restriction endonuclease fold toxin 2 2OG-FeII_Oxy_3 PF13640.1 ESA16378.1 - 0.011 16.2 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ArgJ PF01960.13 ESA16379.1 - 1.4e-147 491.1 7.0 1.6e-147 490.9 4.8 1.0 1 0 0 1 1 1 1 ArgJ family Arrestin_N PF00339.24 ESA16381.1 - 7e-11 42.1 0.0 1.1e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Rxt3 PF08642.5 ESA16382.1 - 2.6e-07 30.8 0.3 5.2e-05 23.4 0.1 2.2 1 1 1 2 2 2 2 Histone deacetylation protein Rxt3 Tic20 PF09685.5 ESA16383.1 - 3 7.8 8.0 11 6.0 5.5 1.8 1 1 0 1 1 1 0 Tic20-like protein tRNA_U5-meth_tr PF05958.6 ESA16384.1 - 0.088 11.4 0.1 0.091 11.4 0.1 1.0 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Lipase_3 PF01764.20 ESA16386.1 - 7.8e-21 74.1 0.0 1.4e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Inhibitor_I29 PF08246.7 ESA16386.1 - 2.5 8.4 5.5 2.1 8.6 0.2 2.7 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) CYTL1 PF15153.1 ESA16387.1 - 0.02 14.5 0.2 0.033 13.8 0.2 1.3 1 0 0 1 1 1 0 Cytokine-like protein 1 Tafi-CsgC PF10610.4 ESA16387.1 - 0.051 13.4 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Thin aggregative fimbriae synthesis protein UQ_con PF00179.21 ESA16388.1 - 1.6e-46 157.1 0.0 1.8e-46 157.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA16388.1 - 0.0048 16.7 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA16388.1 - 0.13 11.9 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 UEV domain UQ_con PF00179.21 ESA16389.1 - 8e-47 158.1 0.0 1.2e-46 157.6 0.0 1.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA16389.1 - 0.005 16.7 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA16389.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain HSP20 PF00011.16 ESA16391.1 - 1.4e-23 82.6 0.1 1.7e-23 82.3 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 ESA16391.1 - 0.1 13.1 0.1 0.95 10.0 0.1 2.1 1 1 1 2 2 2 0 CS domain UBA_4 PF14555.1 ESA16391.1 - 0.11 12.0 0.5 0.23 11.0 0.3 1.5 1 0 0 1 1 1 0 UBA-like domain adh_short PF00106.20 ESA16392.1 - 7.2e-60 201.6 11.2 2.8e-31 108.6 1.9 2.3 2 0 0 2 2 2 2 short chain dehydrogenase MaoC_dehydratas PF01575.14 ESA16392.1 - 1e-30 105.6 0.0 2.8e-30 104.2 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain KR PF08659.5 ESA16392.1 - 6.2e-30 104.1 7.2 3.4e-16 59.4 0.9 2.2 2 0 0 2 2 2 2 KR domain SCP2 PF02036.12 ESA16392.1 - 3.7e-27 94.5 0.4 1.3e-26 92.8 0.2 2.0 2 0 0 2 2 2 1 SCP-2 sterol transfer family MaoC_dehydrat_N PF13452.1 ESA16392.1 - 1.7e-15 56.9 0.0 9.1e-15 54.6 0.0 2.2 3 0 0 3 3 3 1 N-terminal half of MaoC dehydratase Alkyl_sulf_C PF14864.1 ESA16392.1 - 0.00016 21.6 0.0 0.012 15.6 0.0 2.5 2 0 0 2 2 2 1 Alkyl sulfatase C-terminal Epimerase PF01370.16 ESA16392.1 - 0.00017 21.0 2.6 0.047 13.1 0.2 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 ESA16392.1 - 0.0029 16.6 2.5 0.048 12.7 0.2 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4161 PF13722.1 ESA16392.1 - 0.031 14.5 0.8 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 C-terminal domain on CstA (DUF4161) WD40 PF00400.27 ESA16393.1 - 1.9e-63 208.2 22.3 2.8e-08 33.3 0.0 11.4 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.7 ESA16393.1 - 2e-22 79.1 1.2 3.8e-22 78.2 0.8 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 ESA16393.1 - 5.2e-06 24.8 4.9 0.28 9.2 0.1 5.1 4 2 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA16393.1 - 4e-05 22.5 9.6 3.7 6.1 0.0 6.2 3 2 2 6 6 6 4 Nup133 N terminal like CDI PF02234.14 ESA16393.1 - 3.7 7.4 5.6 20 5.0 0.1 3.4 3 0 0 3 3 3 0 Cyclin-dependent kinase inhibitor 2-oxoacid_dh PF00198.18 ESA16394.1 - 6.2e-70 235.0 0.0 1.8e-69 233.5 0.0 1.7 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 ESA16394.1 - 3.9e-19 68.0 0.1 7.6e-19 67.1 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 ESA16394.1 - 1.4e-15 56.5 0.0 2.4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 e3 binding domain NT-C2 PF10358.4 ESA16395.1 - 3.3e-28 97.9 1.9 4.3e-28 97.5 1.3 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins BTB PF00651.26 ESA16396.1 - 3.9e-17 62.2 0.1 8.5e-17 61.1 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16396.1 - 8.6e-14 51.7 0.6 8.6e-14 51.7 0.4 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA16396.1 - 0.0033 17.2 0.3 0.055 13.3 0.0 2.6 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA16396.1 - 0.0098 15.0 0.1 0.015 14.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB_2 PF02214.17 ESA16399.1 - 2.1e-10 40.6 0.0 4.6e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF2207 PF09972.4 ESA16400.1 - 0.22 10.0 1.3 0.23 10.0 0.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Yip1 PF04893.12 ESA16400.1 - 0.36 10.3 12.0 0.94 8.9 8.2 1.6 1 1 0 1 1 1 0 Yip1 domain DUF4233 PF14017.1 ESA16400.1 - 0.79 9.6 9.5 8.4 6.3 6.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4233) DnaJ PF00226.26 ESA16401.1 - 3.5e-18 65.0 0.7 5.6e-18 64.4 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain DNAPolymera_Pol PF11590.3 ESA16401.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol Ribosomal_S18 PF01084.15 ESA16402.1 - 1.4e-22 79.2 0.3 4.6e-22 77.6 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 LRR_8 PF13855.1 ESA16403.1 - 0.54 10.0 18.2 0.33 10.7 0.2 6.1 5 2 1 7 7 7 0 Leucine rich repeat LRR_7 PF13504.1 ESA16403.1 - 2.2 8.8 7.3 1.1e+02 3.7 0.1 5.4 5 0 0 5 5 5 0 Leucine rich repeat zf-like PF04071.7 ESA16405.1 - 0.11 12.2 0.1 0.12 12.0 0.0 1.3 1 1 0 1 1 1 0 Cysteine-rich small domain DUF4414 PF14377.1 ESA16407.1 - 0.07 13.0 0.2 0.07 13.0 0.2 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4414) RRM_1 PF00076.17 ESA16408.1 - 0.057 13.0 0.3 0.14 11.8 0.1 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nucleoporin_FG PF13634.1 ESA16414.1 - 0.082 13.1 0.3 0.084 13.1 0.2 1.0 1 0 0 1 1 1 0 Nucleoporin FG repeat region Toxin_39 PF15500.1 ESA16415.1 - 0.012 15.7 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Putative RNase-like toxin Fic PF02661.13 ESA16416.1 - 9.1e-14 51.9 0.0 2e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Fic/DOC family DUF2763 PF10961.3 ESA16417.1 - 0.29 11.5 1.1 0.39 11.1 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2763) LRR_6 PF13516.1 ESA16418.1 - 0.039 14.0 0.6 0.069 13.2 0.4 1.5 1 1 0 1 1 1 0 Leucine Rich repeat UDPGT PF00201.13 ESA16420.1 - 7.5e-12 44.5 0.0 2.9e-11 42.6 0.0 1.9 2 1 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.1 ESA16420.1 - 3.9e-05 23.0 0.2 0.0068 15.6 0.0 2.6 2 1 1 3 3 3 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 ESA16420.1 - 0.0046 16.6 0.0 0.0084 15.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.1 ESA16420.1 - 0.056 13.5 0.0 4.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Glycosyl transferases group 1 AF1Q PF15017.1 ESA16420.1 - 0.082 12.8 0.1 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator Shisa PF13908.1 ESA16420.1 - 0.12 12.5 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator HATPase_c PF02518.21 ESA16422.1 - 1.3e-23 82.8 0.1 3.9e-23 81.2 0.1 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 ESA16422.1 - 3.5e-10 39.8 0.1 8.6e-10 38.6 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 ESA16422.1 - 6e-10 38.9 0.1 1.6e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.1 ESA16422.1 - 0.00011 21.9 0.0 0.00023 20.9 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.1 ESA16422.1 - 0.0092 15.6 0.1 0.023 14.3 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMG_box PF00505.14 ESA16424.1 - 4.8e-05 23.5 0.3 0.00012 22.2 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA16424.1 - 0.0018 18.6 0.1 0.0037 17.5 0.1 1.6 1 0 0 1 1 1 1 HMG-box domain Maf1 PF09174.5 ESA16424.1 - 0.0044 16.8 1.5 0.0093 15.8 1.1 1.5 1 0 0 1 1 1 1 Maf1 regulator GPP34 PF05719.6 ESA16424.1 - 0.13 12.3 0.0 11 6.0 0.0 2.1 1 1 1 2 2 2 0 Golgi phosphoprotein 3 (GPP34) YtxH PF12732.2 ESA16424.1 - 0.23 11.8 0.8 0.39 11.1 0.6 1.3 1 0 0 1 1 1 0 YtxH-like protein YvrJ PF12841.2 ESA16425.1 - 0.1 11.9 1.1 5.3 6.4 0.1 3.5 3 1 1 4 4 4 0 YvrJ protein family K1 PF02960.9 ESA16426.1 - 0.00015 21.8 0.1 0.00015 21.8 0.1 1.5 2 0 0 2 2 2 1 K1 glycoprotein Alpha_GJ PF03229.8 ESA16426.1 - 0.012 15.9 0.5 0.02 15.2 0.3 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J Herpes_capsid PF06112.6 ESA16426.1 - 8.6 6.3 9.2 13 5.7 6.4 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Pkinase_Tyr PF07714.12 ESA16427.1 - 8e-51 172.5 0.1 1.1e-50 172.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16427.1 - 9.3e-48 162.6 0.8 1.5e-47 161.9 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA16427.1 - 1.5e-30 104.8 3.2 1.5e-10 41.3 0.2 4.4 4 0 0 4 4 4 3 Sel1 repeat Kinase-like PF14531.1 ESA16427.1 - 2.4e-05 23.4 0.0 0.0001 21.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA16427.1 - 0.00038 19.8 0.5 0.0012 18.2 0.4 1.9 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA16427.1 - 0.0068 15.5 0.1 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA16427.1 - 0.011 15.0 0.1 0.025 13.8 0.1 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ESA16427.1 - 0.046 13.4 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Vel1p PF10339.4 ESA16429.1 - 0.057 12.5 0.0 0.058 12.5 0.0 1.0 1 0 0 1 1 1 0 Yeast-specific zinc responsive RdRP_3 PF00998.18 ESA16430.1 - 0.11 11.0 0.1 0.13 10.7 0.1 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase Sel1 PF08238.7 ESA16431.1 - 1.1e-08 35.3 0.1 0.0015 19.1 0.0 3.5 4 0 0 4 4 4 2 Sel1 repeat HGD-D PF06050.8 ESA16431.1 - 0.086 11.6 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component TPR_2 PF07719.12 ESA16431.1 - 6.9 6.8 5.8 34 4.6 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16431.1 - 8.5 6.4 9.1 11 6.0 2.4 3.8 2 2 3 5 5 5 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 ESA16434.1 - 6.6e-10 38.2 0.0 4.5e-05 22.4 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family MOR2-PAG1_N PF14222.1 ESA16435.1 - 2.7e-149 498.3 1.0 4.8e-149 497.5 0.7 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 ESA16435.1 - 1.2e-79 267.7 0.8 4e-79 266.0 0.6 1.9 1 0 0 1 1 1 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 ESA16435.1 - 2e-61 207.8 14.9 1.4e-24 85.9 0.1 4.9 2 1 2 4 4 4 4 Cell morphogenesis central region Myb_DNA-binding PF00249.26 ESA16437.1 - 0.00065 19.6 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SAM_1 PF00536.25 ESA16437.1 - 0.0026 17.9 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Myb_DNA-bind_6 PF13921.1 ESA16437.1 - 0.015 15.4 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Nop14 PF04147.7 ESA16438.1 - 0.00076 17.5 23.1 0.00095 17.2 16.0 1.2 1 0 0 1 1 1 1 Nop14-like family Homez PF11569.3 ESA16438.1 - 0.027 13.5 0.2 2.7 7.1 0.0 2.5 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez DUF1153 PF06627.6 ESA16438.1 - 0.05 13.4 0.1 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) TPR_6 PF13174.1 ESA16438.1 - 0.075 13.5 0.1 6.4 7.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_28 PF13518.1 ESA16438.1 - 0.079 12.9 2.4 6.9 6.7 0.2 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HALZ PF02183.13 ESA16438.1 - 0.094 12.4 7.6 0.13 11.9 2.7 2.5 1 1 1 2 2 2 0 Homeobox associated leucine zipper Sigma70_ner PF04546.8 ESA16438.1 - 0.14 11.7 26.7 0.022 14.3 14.9 2.2 2 1 0 2 2 2 0 Sigma-70, non-essential region DUF2457 PF10446.4 ESA16438.1 - 0.33 9.6 25.0 0.57 8.8 17.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DivIC PF04977.10 ESA16438.1 - 0.74 9.3 6.6 0.47 9.9 0.8 2.7 1 1 1 2 2 2 0 Septum formation initiator DUF904 PF06005.7 ESA16438.1 - 1.7 8.9 10.7 0.26 11.6 3.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Striatin PF08232.7 ESA16438.1 - 2.1 8.6 21.0 0.65 10.3 8.2 2.6 2 1 0 2 2 2 0 Striatin family CobT PF06213.7 ESA16438.1 - 4.1 6.4 21.1 4.8 6.2 13.9 1.6 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT NMT PF01233.14 ESA16443.1 - 3.8e-79 263.9 0.7 6.2e-79 263.2 0.0 1.7 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 ESA16443.1 - 2e-73 245.8 1.8 1.1e-72 243.4 0.3 2.1 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_1 PF00583.19 ESA16443.1 - 0.032 14.2 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA16443.1 - 0.044 13.9 0.0 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA16443.1 - 0.1 12.4 0.0 0.39 10.5 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FAR1 PF03101.10 ESA16444.1 - 2.1e-13 50.5 1.3 4.2e-13 49.6 0.9 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA16444.1 - 0.13 11.8 0.2 5.1 6.7 0.0 2.3 2 0 0 2 2 2 0 MuDR family transposase Brix PF04427.13 ESA16445.1 - 1.2e-32 113.0 2.1 4.5e-32 111.2 1.4 1.8 1 1 0 1 1 1 1 Brix domain Ank_2 PF12796.2 ESA16446.1 - 2.8e-33 114.1 2.2 2.5e-18 66.1 0.3 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 ESA16446.1 - 3.3e-23 80.2 0.0 1.1e-09 37.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 ESA16446.1 - 2e-21 75.9 0.6 3.4e-08 33.7 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA16446.1 - 5.2e-19 66.4 0.1 6.2e-07 29.0 0.0 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 ESA16446.1 - 1.9e-17 62.9 0.1 1.7e-09 37.5 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Pan_kinase PF03309.9 ESA16446.1 - 0.55 9.7 2.4 0.6 9.5 0.1 2.1 3 0 0 3 3 3 0 Type III pantothenate kinase Vps55 PF04133.9 ESA16447.1 - 2.8e-43 146.4 2.4 3.2e-43 146.2 1.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 7TMR-DISM_7TM PF07695.6 ESA16447.1 - 0.0032 17.1 6.2 0.004 16.8 4.3 1.0 1 0 0 1 1 1 1 7TM diverse intracellular signalling Herpes_LMP1 PF05297.6 ESA16447.1 - 0.069 12.0 0.4 0.099 11.5 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) SdpI PF13630.1 ESA16447.1 - 2.6 7.8 7.3 6 6.6 0.1 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family Mito_carr PF00153.22 ESA16448.1 - 1.1e-31 108.4 0.0 1.7e-17 62.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Rhomboid PF01694.17 ESA16449.1 - 2.2e-27 95.8 10.7 2.2e-27 95.8 7.4 1.5 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.5 ESA16449.1 - 0.00042 20.5 1.0 0.0007 19.8 0.1 1.8 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) UNC-50 PF05216.8 ESA16449.1 - 0.057 12.6 5.9 0.15 11.2 4.1 1.7 1 1 0 1 1 1 0 UNC-50 family DUF308 PF03729.8 ESA16449.1 - 3.7 7.6 7.9 2 8.4 0.0 3.1 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) Ribosomal_L6e PF01159.14 ESA16450.1 - 2e-37 127.7 2.2 2e-37 127.7 1.6 1.5 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.10 ESA16450.1 - 1.5e-13 50.3 1.3 1.5e-13 50.3 0.9 2.3 2 1 0 2 2 2 1 Ribosomal protein L6, N-terminal domain eIF3_N PF09440.5 ESA16451.1 - 1.4e-48 164.4 4.1 4.4e-48 162.8 2.8 1.9 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.22 ESA16451.1 - 7.5e-09 35.8 0.7 4.4e-05 23.7 0.0 3.4 3 0 0 3 3 3 2 PCI domain Phage_pRha PF09669.5 ESA16451.1 - 0.041 14.2 0.6 8.1 6.8 0.0 2.7 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) RPN7 PF10602.4 ESA16452.1 - 2.2e-60 203.0 1.2 3.2e-60 202.5 0.9 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 ESA16452.1 - 4.1e-15 55.9 0.9 1.4e-14 54.2 0.0 2.4 4 0 0 4 4 3 1 PCI domain SAC3_GANP PF03399.11 ESA16452.1 - 0.0012 18.4 2.2 0.0012 18.4 1.5 1.7 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family TPR_7 PF13176.1 ESA16452.1 - 0.0084 15.8 0.2 0.11 12.3 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA16452.1 - 0.0094 15.0 0.7 0.016 14.2 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16452.1 - 0.015 15.1 1.0 0.062 13.2 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16452.1 - 0.019 15.5 0.0 0.17 12.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16452.1 - 0.02 14.6 0.2 0.11 12.3 0.1 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16452.1 - 0.024 15.3 0.2 0.15 12.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16452.1 - 0.15 11.7 1.9 0.37 10.4 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16452.1 - 0.34 11.4 2.9 0.55 10.8 0.2 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat SET PF00856.23 ESA16453.1 - 7.8e-14 52.3 0.1 2.8e-13 50.5 0.0 1.9 1 1 0 1 1 1 1 SET domain FAM176 PF14851.1 ESA16453.1 - 0.013 15.2 2.1 0.023 14.3 1.5 1.4 1 0 0 1 1 1 0 FAM176 family Rubis-subs-bind PF09273.6 ESA16453.1 - 0.013 15.4 0.3 0.013 15.4 0.2 1.8 2 0 0 2 2 2 0 Rubisco LSMT substrate-binding Nucleoplasmin PF03066.10 ESA16453.1 - 0.017 14.6 5.1 0.037 13.5 3.5 1.5 1 0 0 1 1 1 0 Nucleoplasmin Myc_N PF01056.13 ESA16453.1 - 0.54 9.3 3.6 0.84 8.7 2.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF2457 PF10446.4 ESA16453.1 - 0.98 8.0 8.1 1.5 7.4 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.5 ESA16453.1 - 1.6 8.9 10.6 3.2 8.0 7.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DMRL_synthase PF00885.14 ESA16454.1 - 2.7e-40 137.3 0.1 6.1e-24 84.3 0.0 2.0 2 0 0 2 2 2 2 6,7-dimethyl-8-ribityllumazine synthase NUDIX PF00293.23 ESA16455.1 - 6.6e-19 67.8 0.4 8.4e-19 67.5 0.3 1.1 1 0 0 1 1 1 1 NUDIX domain DUF3782 PF12644.2 ESA16455.1 - 0.061 13.1 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) DUF2802 PF10975.3 ESA16455.1 - 0.092 12.5 0.0 0.27 10.9 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2802) P68HR PF08061.6 ESA16455.1 - 1 9.1 3.0 0.45 10.3 0.2 1.7 2 0 0 2 2 2 0 P68HR (NUC004) repeat Ste50p-SAM PF09235.5 ESA16456.1 - 0.001 19.0 0.9 0.0019 18.1 0.0 1.8 2 0 0 2 2 2 1 Ste50p, sterile alpha motif SAM_2 PF07647.12 ESA16456.1 - 0.0073 16.1 0.1 0.015 15.1 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA16456.1 - 0.012 15.7 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Sel1 PF08238.7 ESA16457.1 - 2e-70 231.6 24.1 7.1e-08 32.8 0.1 10.3 10 0 0 10 10 10 10 Sel1 repeat Pkinase_Tyr PF07714.12 ESA16457.1 - 3.8e-28 98.2 0.3 9.3e-28 96.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16457.1 - 4.6e-22 78.4 2.6 4.9e-22 78.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA16457.1 - 2.4e-06 27.6 16.5 0.21 12.1 0.1 7.4 7 1 1 8 8 8 3 Tetratricopeptide repeat Kinase-like PF14531.1 ESA16457.1 - 8.7e-05 21.6 0.0 0.00022 20.3 0.0 1.6 2 0 0 2 2 2 1 Kinase-like DUF2235 PF09994.4 ESA16457.1 - 0.015 14.6 3.9 5.6 6.2 0.0 4.1 1 1 1 4 4 4 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_16 PF13432.1 ESA16457.1 - 0.084 13.5 3.9 22 5.8 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.15 ESA16457.1 - 0.088 12.8 14.2 33 4.7 0.0 7.6 8 0 0 8 8 8 0 PPR repeat Transposase_21 PF02992.9 ESA16458.1 - 1.3e-13 50.5 0.4 4.4e-13 48.8 0.0 1.8 1 1 1 2 2 2 1 Transposase family tnp2 DUF4218 PF13960.1 ESA16459.1 - 0.0048 16.3 0.2 0.014 14.8 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4218) Nop14 PF04147.7 ESA16460.1 - 0.006 14.5 13.9 0.0058 14.6 9.6 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.9 ESA16460.1 - 0.27 9.2 10.3 0.3 9.0 7.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.11 ESA16460.1 - 0.38 9.7 8.6 0.48 9.3 5.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3295 PF11702.3 ESA16460.1 - 0.45 9.4 8.7 0.5 9.2 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) YL1 PF05764.8 ESA16460.1 - 0.85 9.1 16.5 1.1 8.8 11.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF2457 PF10446.4 ESA16460.1 - 1.2 7.7 30.0 1.6 7.3 20.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Astro_capsid PF03115.9 ESA16460.1 - 1.3 7.2 6.3 1.3 7.1 4.4 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF2722 PF10846.3 ESA16460.1 - 1.5 7.7 6.8 1.7 7.5 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1510 PF07423.6 ESA16460.1 - 1.7 7.9 7.1 2.2 7.5 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Daxx PF03344.10 ESA16460.1 - 3.1 6.1 16.7 3.8 5.8 11.6 1.1 1 0 0 1 1 1 0 Daxx Family RRN3 PF05327.6 ESA16460.1 - 3.4 5.6 13.2 4.4 5.2 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIA PF03153.8 ESA16460.1 - 3.8 7.3 17.2 3.6 7.3 11.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FtsL PF04999.8 ESA16464.1 - 0.1 12.3 0.1 0.83 9.4 0.0 2.4 2 0 0 2 2 2 0 Cell division protein FtsL Glyco_hydro_46 PF01374.13 ESA16466.1 - 0.013 15.0 3.0 0.018 14.6 2.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 Oligomerisation PF02410.10 ESA16467.1 - 1.1e-20 73.5 0.0 2.1e-20 72.6 0.0 1.5 1 1 0 1 1 1 1 Oligomerisation domain UDPG_MGDP_dh_C PF03720.10 ESA16467.1 - 0.043 13.9 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Ribosomal_L32p PF01783.18 ESA16468.1 - 4.2e-16 58.8 5.1 4.7e-16 58.7 3.5 1.0 1 0 0 1 1 1 1 Ribosomal L32p protein family eIF3g PF12353.3 ESA16468.1 - 0.016 15.0 0.5 0.017 14.9 0.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Prok-RING_1 PF14446.1 ESA16468.1 - 0.021 14.5 1.2 0.024 14.3 0.8 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DUF2752 PF10825.3 ESA16468.1 - 0.031 14.3 0.4 0.052 13.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Stc1 PF12898.2 ESA16468.1 - 0.1 12.6 1.5 0.12 12.4 1.0 1.1 1 0 0 1 1 1 0 Stc1 domain Spc97_Spc98 PF04130.8 ESA16469.1 - 2.9e-32 111.7 1.0 6.5e-32 110.5 0.7 1.5 1 1 0 1 1 1 1 Spc97 / Spc98 family DUF1298 PF06974.8 ESA16471.1 - 0.0038 17.0 0.2 0.045 13.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1298) SecE PF00584.15 ESA16472.1 - 2.6e-14 52.5 0.1 3e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Complex1_LYR PF05347.10 ESA16473.1 - 9.5e-18 63.7 1.0 1.3e-17 63.3 0.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 ESA16473.1 - 1.7e-17 63.3 1.3 2.1e-17 63.0 0.9 1.1 1 0 0 1 1 1 1 Complex1_LYR-like UPF0122 PF04297.9 ESA16473.1 - 0.026 14.5 0.5 0.032 14.2 0.4 1.2 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Synaphin PF05835.7 ESA16473.1 - 0.096 12.8 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Synaphin protein Ribosomal_S17e PF00833.13 ESA16474.1 - 9.3e-61 202.9 0.8 1.1e-60 202.8 0.6 1.0 1 0 0 1 1 1 1 Ribosomal S17 ubiquitin PF00240.18 ESA16475.1 - 1.5e-102 335.0 17.0 2.5e-34 116.4 0.7 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.3 ESA16475.1 - 1.7e-59 197.4 15.1 1.1e-19 69.8 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA16475.1 - 1.6e-19 69.9 7.3 3.3e-05 24.0 0.2 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ESA16475.1 - 2.5e-15 56.5 0.3 0.0012 18.5 0.0 3.1 3 0 0 3 3 3 3 Telomere stability and silencing DUF2407 PF10302.4 ESA16475.1 - 1.1e-10 41.5 0.6 0.057 13.6 0.0 3.2 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA16475.1 - 1.5e-10 40.9 1.6 0.062 13.1 0.0 3.8 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 ESA16475.1 - 1.4e-07 31.4 0.0 0.99 9.4 0.0 3.7 3 0 0 3 3 3 3 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 ESA16475.1 - 1.6e-07 31.1 2.7 0.46 10.4 0.0 3.2 3 0 0 3 3 3 3 GLUT4 regulating protein TUG Plexin_cytopl PF08337.7 ESA16475.1 - 3.1e-06 25.7 8.7 0.16 10.2 0.3 4.6 4 2 0 4 4 4 3 Plexin cytoplasmic RasGAP domain DUF3221 PF11518.3 ESA16475.1 - 7.7e-05 22.3 0.6 4.1 7.0 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3221) Methyltrans_RNA PF04452.9 ESA16475.1 - 0.00027 20.1 0.2 0.64 9.0 0.0 2.3 2 0 0 2 2 2 2 RNA methyltransferase USP7_C2 PF14533.1 ESA16475.1 - 0.0022 17.4 2.4 4.2 6.7 0.1 3.0 1 1 1 3 3 3 1 Ubiquitin-specific protease C-terminal FlgD_ig PF13860.1 ESA16475.1 - 0.0027 17.4 2.0 5 6.9 0.0 3.3 3 0 0 3 3 3 1 FlgD Ig-like domain RA PF00788.18 ESA16475.1 - 0.005 17.2 0.0 35 4.9 0.0 3.4 3 0 0 3 3 3 0 Ras association (RalGDS/AF-6) domain ANTAR PF03861.9 ESA16475.1 - 0.0071 15.9 0.0 13 5.4 0.0 3.1 3 0 0 3 3 3 0 ANTAR domain ACT_4 PF13291.1 ESA16475.1 - 0.01 16.1 0.2 34 4.8 0.0 3.2 3 0 0 3 3 3 0 ACT domain Tash_PEST PF07708.6 ESA16475.1 - 0.047 13.6 20.2 2.5 8.1 1.2 3.3 3 0 0 3 3 3 0 Tash protein PEST motif EMG1 PF03587.9 ESA16475.1 - 0.06 12.6 0.9 16 4.6 0.0 2.9 3 0 0 3 3 3 0 EMG1/NEP1 methyltransferase FERM_N PF09379.5 ESA16475.1 - 0.065 13.2 9.0 9.8 6.3 0.2 4.7 3 3 0 3 3 3 0 FERM N-terminal domain Sortase PF04203.8 ESA16475.1 - 0.083 12.4 1.2 21 4.7 0.0 2.9 1 1 1 3 3 3 0 Sortase family PcfJ PF14284.1 ESA16475.1 - 0.1 12.0 0.8 35 3.8 0.0 3.1 3 0 0 3 3 3 0 PcfJ-like protein CDC48_2 PF02933.12 ESA16475.1 - 0.12 12.0 9.1 3.8 7.2 0.1 3.2 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 CTDII PF01556.13 ESA16475.1 - 0.13 12.2 9.1 5.2 7.0 0.3 3.4 1 1 2 3 3 3 0 DnaJ C terminal domain DUF39 PF01837.11 ESA16475.1 - 0.24 10.0 1.5 9.2 4.7 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF39 CsbD PF05532.7 ESA16475.1 - 0.27 10.9 2.9 4.4 7.0 0.0 3.0 3 0 0 3 3 3 0 CsbD-like GABP-alpha PF11620.3 ESA16475.1 - 0.47 10.4 4.0 52 3.9 0.1 3.0 3 0 0 3 3 3 0 GA-binding protein alpha chain DUF2207 PF09972.4 ESA16475.1 - 2.1 6.8 9.3 7.7 4.9 0.2 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) TFIIF_alpha PF05793.7 ESA16476.1 - 1.6e-12 46.6 7.5 3.3e-12 45.5 5.2 1.5 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Tricorn_PDZ PF14685.1 ESA16476.1 - 0.1 12.3 0.4 0.25 11.1 0.3 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Sel1 PF08238.7 ESA16477.1 - 4.3e-51 170.2 30.4 2.6e-12 46.9 0.8 7.1 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.1 ESA16477.1 - 0.022 15.1 9.9 2.7 8.6 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16477.1 - 1.6 9.5 5.5 17 6.2 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4367 PF14285.1 ESA16478.1 - 1.6 8.0 9.0 3.7 6.8 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4367) Pkinase_Tyr PF07714.12 ESA16479.1 - 7.8e-36 123.4 0.0 1.1e-35 122.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16479.1 - 1.7e-29 102.7 0.1 2.6e-29 102.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF2704 PF10866.3 ESA16479.1 - 0.028 13.8 0.2 0.21 10.9 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2704) TIP49 PF06068.8 ESA16481.1 - 0.031 13.0 0.0 0.031 12.9 0.0 1.0 1 0 0 1 1 1 0 TIP49 C-terminus Response_reg PF00072.19 ESA16482.1 - 7.8e-22 77.3 1.1 1.6e-21 76.3 0.7 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 ESA16482.1 - 5.9e-07 29.1 0.1 2.1e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DDE_1 PF03184.14 ESA16485.1 - 0.0055 15.8 0.0 0.0069 15.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Myb_DNA-bind_6 PF13921.1 ESA16487.1 - 0.019 15.0 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain Alginate_lyase PF05426.7 ESA16488.1 - 5.4e-64 216.1 1.0 7.5e-64 215.7 0.7 1.2 1 0 0 1 1 1 1 Alginate lyase VASP_tetra PF08776.6 ESA16489.1 - 0.011 15.0 0.3 0.014 14.6 0.2 1.2 1 0 0 1 1 1 0 VASP tetramerisation domain DUF577 PF04510.7 ESA16489.1 - 0.065 12.9 0.1 0.073 12.7 0.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF577) TaqI_C PF12950.2 ESA16490.1 - 0.088 12.5 0.4 0.13 12.0 0.3 1.1 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain CENP-B_N PF04218.8 ESA16491.1 - 1.2e-10 40.6 0.4 1.8e-10 40.0 0.3 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.11 ESA16491.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain HTH_24 PF13412.1 ESA16491.1 - 0.02 14.2 0.1 0.056 12.8 0.1 1.9 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Tnp_4 PF13613.1 ESA16491.1 - 0.032 13.7 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Sel1 PF08238.7 ESA16492.1 - 2.5e-54 180.4 17.1 8e-12 45.4 0.2 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA16492.1 - 0.049 14.0 13.9 6.6 7.4 0.5 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16492.1 - 0.12 12.1 3.0 73 3.5 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA16492.1 - 3.5 7.3 16.9 2 8.1 1.4 4.1 1 1 4 5 5 5 0 TPR repeat TPR_3 PF07720.7 ESA16492.1 - 3.8 7.4 13.6 2.1 8.2 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA16494.1 - 3.3e-97 316.7 30.9 2.1e-11 44.0 0.2 12.4 13 0 0 13 13 13 11 Sel1 repeat TPR_6 PF13174.1 ESA16494.1 - 8.7e-07 29.0 22.1 5.9 7.5 0.2 9.9 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16494.1 - 2.5e-06 27.2 10.3 14 6.1 0.1 8.8 9 1 0 9 9 9 0 Tetratricopeptide repeat ANTAR PF03861.9 ESA16494.1 - 0.0032 17.0 0.5 12 5.5 0.0 3.7 4 0 0 4 4 4 1 ANTAR domain DUF544 PF04424.8 ESA16494.1 - 0.0039 16.9 1.9 9.2 6.0 0.0 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF544) Herpes_teg_N PF04843.7 ESA16494.1 - 0.014 14.8 0.6 21 4.4 0.0 3.2 3 0 0 3 3 3 0 Herpesvirus tegument protein, N-terminal conserved region CLN6 PF15156.1 ESA16494.1 - 0.043 12.9 0.4 14 4.6 0.0 3.5 4 0 0 4 4 4 0 Ceroid-lipofuscinosis neuronal protein 6 TPR_20 PF14561.1 ESA16494.1 - 0.055 13.5 9.7 33 4.6 0.0 5.9 5 2 1 6 6 6 0 Tetratricopeptide repeat DEP PF00610.16 ESA16494.1 - 0.092 12.4 0.0 18 5.1 0.0 3.7 4 0 0 4 4 4 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Arena_glycoprot PF00798.13 ESA16494.1 - 0.22 9.8 0.9 2.3 6.5 0.2 2.3 1 1 3 4 4 4 0 Arenavirus glycoprotein Msg2_C PF12373.3 ESA16494.1 - 1.2 8.4 8.5 28 4.0 0.0 5.3 5 0 0 5 5 5 0 Major surface glycoprotein 2 C terminal Bet_v_1 PF00407.14 ESA16494.1 - 1.2 8.7 10.9 1.5 8.4 0.6 3.6 2 1 2 4 4 4 0 Pathogenesis-related protein Bet v I family Pkinase_Tyr PF07714.12 ESA16495.1 - 4e-16 58.8 0.1 2.1e-09 36.8 0.0 4.1 3 1 1 4 4 4 4 Protein tyrosine kinase Pkinase PF00069.20 ESA16495.1 - 2.5e-10 39.9 0.7 3e-06 26.5 0.1 2.8 2 1 1 3 3 3 2 Protein kinase domain DZR PF12773.2 ESA16495.1 - 0.0051 16.6 1.8 0.055 13.3 0.5 2.3 2 0 0 2 2 2 1 Double zinc ribbon Rio2_N PF09202.6 ESA16495.1 - 0.037 14.0 0.0 4.4 7.4 0.0 3.6 4 0 0 4 4 4 0 Rio2, N-terminal HypA PF01155.14 ESA16495.1 - 0.19 11.4 1.0 0.63 9.7 0.2 2.0 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-ribbon_3 PF13248.1 ESA16495.1 - 0.8 8.9 6.3 0.26 10.5 1.9 1.9 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_4 PF13894.1 ESA16495.1 - 9.3 6.8 6.9 40 4.8 3.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger ELO PF01151.13 ESA16496.1 - 2.9e-58 197.1 27.3 2.9e-58 197.1 18.9 1.3 2 0 0 2 2 2 1 GNS1/SUR4 family TPR_11 PF13414.1 ESA16497.1 - 4.5e-35 119.1 14.4 8e-08 31.8 0.0 8.1 6 2 0 7 7 7 6 TPR repeat TPR_2 PF07719.12 ESA16497.1 - 6.3e-27 91.2 13.4 0.0024 17.6 0.0 11.9 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16497.1 - 3e-25 86.7 15.2 0.00033 20.1 0.2 10.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16497.1 - 1.7e-21 74.7 1.1 0.0034 17.8 0.0 10.7 7 3 4 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16497.1 - 2.3e-20 72.2 10.1 0.0026 17.6 0.0 10.1 7 2 4 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16497.1 - 7.9e-20 71.0 0.0 9e-05 23.0 0.0 8.9 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16497.1 - 4.8e-17 60.3 19.9 0.022 14.5 0.0 10.8 13 0 0 13 13 11 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16497.1 - 6.9e-17 61.5 8.5 0.00061 20.0 1.4 8.3 7 2 2 10 10 9 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16497.1 - 3.7e-16 57.5 12.3 0.028 14.2 0.0 10.5 11 1 1 12 12 10 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA16497.1 - 1.6e-15 57.0 1.4 0.00026 21.0 0.0 6.2 5 1 1 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 ESA16497.1 - 3.3e-12 45.9 2.6 0.21 12.1 0.0 8.2 10 0 0 10 10 7 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESA16497.1 - 6.3e-12 45.1 0.0 0.0098 15.7 0.0 5.8 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16497.1 - 8.8e-11 41.1 10.1 0.0091 16.1 0.0 10.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA16497.1 - 2.3e-06 27.6 0.1 0.69 10.0 1.2 5.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA16497.1 - 0.0064 16.3 15.4 0.32 11.0 0.2 6.7 8 0 0 8 8 8 2 Tetratricopeptide repeat Blt1 PF12754.2 ESA16497.1 - 0.007 16.0 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Cell-cycle control medial ring component DUF1765 PF08578.5 ESA16498.1 - 1.2e-26 93.2 7.3 3e-26 91.9 5.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Gcd10p PF04189.8 ESA16499.1 - 1.6e-78 263.8 4.1 1.6e-78 263.8 2.8 2.5 2 1 0 2 2 2 1 Gcd10p family Rep_fac_C PF08542.6 ESA16499.1 - 0.008 16.1 0.6 0.053 13.5 0.2 2.4 2 1 0 2 2 2 1 Replication factor C C-terminal domain Copper-fist PF00649.13 ESA16500.1 - 3.2e-20 71.0 0.6 3.2e-20 71.0 0.4 3.0 2 1 1 3 3 3 1 Copper fist DNA binding domain LIM PF00412.17 ESA16501.1 - 0.034 14.2 2.9 0.076 13.0 2.0 1.6 1 0 0 1 1 1 0 LIM domain Toxin_61 PF15538.1 ESA16502.1 - 0.14 12.1 0.0 0.15 12.0 0.0 1.0 1 0 0 1 1 1 0 Putative toxin 61 DNA_pol3_a_NII PF11490.3 ESA16503.1 - 0.15 11.6 0.7 0.21 11.2 0.4 1.4 1 1 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Pkinase_Tyr PF07714.12 ESA16505.1 - 8.3e-41 139.7 0.0 1.2e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16505.1 - 5.2e-37 127.3 0.1 1.4e-36 125.9 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Sugar_tr PF00083.19 ESA16506.1 - 5.3e-48 163.7 25.2 1.3e-47 162.4 17.5 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESA16506.1 - 9.7e-26 90.3 43.6 5.2e-25 87.9 16.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily CAT PF00302.13 ESA16506.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase Dimer_Tnp_hAT PF05699.9 ESA16507.1 - 9.8e-15 53.9 0.1 1.1e-14 53.8 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Dimer_Tnp_hAT PF05699.9 ESA16508.1 - 2.5e-14 52.6 0.1 3e-14 52.4 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region GLTP PF08718.6 ESA16509.1 - 1.1e-07 31.9 0.0 4.1e-07 30.1 0.0 1.6 1 1 1 2 2 2 1 Glycolipid transfer protein (GLTP) Feld-I_B PF09252.5 ESA16509.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Allergen Fel d I-B chain Sel1 PF08238.7 ESA16510.1 - 3.3e-49 164.2 4.9 6.2e-11 42.5 0.1 5.3 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA16510.1 - 2.2e-06 27.7 3.2 0.8 10.3 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16510.1 - 1.5e-05 24.7 1.7 4 7.8 0.0 4.5 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16510.1 - 2.9e-05 23.8 7.0 0.04 13.8 0.0 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16510.1 - 0.00052 19.6 0.4 0.95 9.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA16510.1 - 0.0007 19.2 5.8 0.22 11.2 0.3 3.2 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 ESA16510.1 - 0.0011 18.4 19.0 0.0023 17.4 0.1 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16510.1 - 0.0013 18.4 16.5 0.018 14.9 0.0 5.6 7 0 0 7 7 6 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA16510.1 - 0.013 15.6 3.9 0.11 12.6 0.5 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 ESA16510.1 - 0.013 15.4 0.0 1.7 8.6 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16510.1 - 0.03 14.9 0.0 2.5 8.9 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16510.1 - 0.031 14.9 0.5 0.28 11.9 0.1 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16510.1 - 0.079 13.3 0.6 16 5.9 0.8 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16510.1 - 0.082 12.7 0.2 0.082 12.7 0.1 5.2 5 2 1 6 6 6 0 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA16510.1 - 0.2 11.4 1.0 1.2 8.9 0.2 2.4 2 1 1 3 3 3 0 Aurora-A binding MIT PF04212.13 ESA16510.1 - 2.8 7.8 10.1 17 5.4 0.2 4.4 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA16511.1 - 1.5e-116 378.2 25.5 9.5e-10 38.7 0.5 12.1 12 0 0 12 12 12 12 Sel1 repeat MIT PF04212.13 ESA16511.1 - 7.1e-07 29.0 30.5 0.098 12.5 1.9 7.8 6 3 0 6 6 6 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA16511.1 - 1.6e-05 25.0 20.8 9.6 6.9 0.0 10.0 11 0 0 11 11 11 1 Tetratricopeptide repeat DUF4376 PF14301.1 ESA16511.1 - 0.00011 22.2 0.1 4.5 7.4 0.0 4.1 1 1 2 4 4 4 1 Domain of unknown function (DUF4376) TPR_11 PF13414.1 ESA16511.1 - 0.0061 16.1 40.2 0.08 12.6 0.8 7.5 4 3 2 7 7 7 3 TPR repeat Glyco_hydro_38 PF01074.17 ESA16511.1 - 0.047 12.9 4.2 0.87 8.7 0.1 3.1 1 1 1 2 2 2 0 Glycosyl hydrolases family 38 N-terminal domain PPR PF01535.15 ESA16511.1 - 0.075 13.0 10.5 12 6.1 0.1 6.3 7 0 0 7 7 7 0 PPR repeat TPR_7 PF13176.1 ESA16511.1 - 0.095 12.5 14.6 15 5.6 0.1 6.8 7 1 1 8 8 8 0 Tetratricopeptide repeat 23S_rRNA_IVP PF05635.6 ESA16511.1 - 0.2 11.5 2.6 3.2 7.7 0.1 3.7 5 0 0 5 5 5 0 23S rRNA-intervening sequence protein DUF3303 PF11746.3 ESA16511.1 - 0.39 11.1 3.6 46 4.4 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3303) TPR_12 PF13424.1 ESA16511.1 - 0.41 10.6 29.8 1.7 8.6 0.1 8.2 4 1 4 8 8 8 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16511.1 - 0.5 10.6 22.5 30 5.1 0.2 9.6 6 3 5 11 11 11 0 Tetratricopeptide repeat DUF1031 PF06275.6 ESA16511.1 - 0.89 9.6 5.9 2.2 8.3 0.1 3.8 5 0 0 5 5 4 0 Protein of unknown function (DUF1031) PRD PF00874.15 ESA16511.1 - 1.2 9.2 5.9 21 5.3 0.1 4.0 4 0 0 4 4 4 0 PRD domain Aurora-A_bind PF09041.5 ESA16511.1 - 1.4 8.7 4.0 6.6 6.5 0.1 3.5 4 0 0 4 4 4 0 Aurora-A binding Sel1 PF08238.7 ESA16512.1 - 8.5e-37 124.7 17.0 5.5e-08 33.2 0.1 7.1 7 0 0 7 7 7 6 Sel1 repeat Viral_NABP PF05515.6 ESA16512.1 - 0.026 14.7 0.4 5 7.4 0.0 2.3 2 0 0 2 2 2 0 Viral nucleic acid binding DUF1392 PF07154.6 ESA16512.1 - 0.14 11.9 0.4 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1392) DSPc PF00782.15 ESA16516.1 - 1.1e-35 122.0 0.2 1.3e-35 121.8 0.1 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA16516.1 - 1.5e-06 27.7 0.0 1.6e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 ESA16516.1 - 0.00012 22.1 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF816 PF05674.7 ESA16516.1 - 0.037 13.7 0.5 0.065 12.9 0.2 1.4 1 1 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) EVE PF01878.13 ESA16517.1 - 2.7e-55 186.3 1.2 2.9e-55 186.2 0.3 1.4 2 0 0 2 2 2 1 EVE domain Toxin_63 PF15541.1 ESA16518.1 - 0.13 12.1 0.0 0.16 11.9 0.0 1.0 1 0 0 1 1 1 0 Putative toxin 63 F-box-like PF12937.2 ESA16519.1 - 0.00015 21.3 0.3 0.00066 19.3 0.2 2.2 1 0 0 1 1 1 1 F-box-like GAT PF03127.9 ESA16519.1 - 0.0085 16.0 0.0 0.036 14.0 0.0 2.0 2 0 0 2 2 2 1 GAT domain Thioredoxin_6 PF13848.1 ESA16519.1 - 0.021 14.6 0.2 0.082 12.7 0.1 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain LRR_8 PF13855.1 ESA16519.1 - 0.67 9.7 5.8 0.43 10.3 0.1 3.4 4 0 0 4 4 4 0 Leucine rich repeat Rsa3 PF14615.1 ESA16520.1 - 0.079 12.2 0.1 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Ribosome-assembly protein 3 LppC PF04348.8 ESA16520.1 - 0.099 11.1 1.0 0.11 11.0 0.7 1.2 1 0 0 1 1 1 0 LppC putative lipoprotein DUF4413 PF14372.1 ESA16523.1 - 1.4e-06 28.2 0.0 1.4e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) CPDase PF07823.6 ESA16523.1 - 0.1 12.0 0.1 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein Dimer_Tnp_hAT PF05699.9 ESA16524.1 - 2.1e-17 62.5 0.2 2.3e-17 62.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region VIT PF08487.5 ESA16525.1 - 0.038 13.6 0.1 0.076 12.7 0.0 1.6 1 1 0 1 1 1 0 Vault protein inter-alpha-trypsin domain CBM_6 PF03422.10 ESA16525.1 - 0.11 12.7 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) SH3_8 PF13457.1 ESA16526.1 - 0.02 15.0 0.8 0.04 14.0 0.5 1.6 1 0 0 1 1 1 0 SH3-like domain DUF3236 PF11576.3 ESA16527.1 - 0.0057 16.0 2.5 0.0061 15.9 1.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3236) Sugar_tr PF00083.19 ESA16528.1 - 2.1e-49 168.3 21.9 3.4e-48 164.3 15.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 ESA16528.1 - 8.4e-33 113.5 25.8 2.4e-31 108.7 3.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily CDC45 PF02724.9 ESA16528.1 - 0.059 11.3 2.7 0.088 10.8 1.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Pex14_N PF04695.8 ESA16528.1 - 0.06 13.3 2.6 0.14 12.2 1.8 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2457 PF10446.4 ESA16528.1 - 0.16 10.6 13.9 0.25 10.0 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TT_ORF1 PF02956.9 ESA16528.1 - 0.34 9.2 6.1 0.49 8.7 4.2 1.1 1 0 0 1 1 1 0 TT viral orf 1 Zip PF02535.17 ESA16528.1 - 1.6 7.6 9.5 0.46 9.4 2.6 2.6 2 1 1 3 3 3 0 ZIP Zinc transporter Pkr1 PF08636.5 ESA16529.1 - 1 9.4 3.9 1.3 9.1 2.7 1.1 1 0 0 1 1 1 0 ER protein Pkr1 Dsl1_N PF11988.3 ESA16530.1 - 0.0051 15.7 1.4 0.0057 15.5 1.0 1.0 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 N terminal DUF1818 PF08848.6 ESA16530.1 - 0.1 12.6 1.2 2 8.5 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1818) RIX1 PF08167.7 ESA16530.1 - 0.1 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis GatB_Yqey PF02637.13 ESA16531.1 - 0.079 12.6 0.0 5.2 6.7 0.0 2.1 1 1 1 2 2 2 0 GatB domain zf-U1 PF06220.7 ESA16532.1 - 0.0024 17.3 3.2 0.0047 16.4 2.2 1.4 1 0 0 1 1 1 1 U1 zinc finger DUF972 PF06156.8 ESA16532.1 - 0.0072 16.6 6.2 0.013 15.8 4.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF972) zf-BED PF02892.10 ESA16532.1 - 0.011 15.4 1.0 0.025 14.3 0.7 1.5 1 0 0 1 1 1 0 BED zinc finger CENP-Q PF13094.1 ESA16532.1 - 0.016 15.2 7.4 0.026 14.5 5.2 1.3 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit CASP_C PF08172.7 ESA16532.1 - 0.032 13.2 7.0 0.058 12.4 4.8 1.5 1 1 0 1 1 1 0 CASP C terminal XRCC4 PF06632.7 ESA16532.1 - 0.045 12.6 4.7 0.059 12.2 3.3 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Mnd1 PF03962.10 ESA16532.1 - 0.066 12.8 6.1 0.096 12.3 4.2 1.2 1 0 0 1 1 1 0 Mnd1 family Sgf11 PF08209.6 ESA16532.1 - 0.068 12.4 0.2 0.14 11.4 0.1 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) zf-FCS PF06467.9 ESA16532.1 - 0.082 12.5 0.8 0.21 11.2 0.6 1.6 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Hormone_1 PF00103.15 ESA16532.1 - 0.084 12.1 3.2 0.15 11.4 2.2 1.4 1 0 0 1 1 1 0 Somatotropin hormone family zf-C2H2_jaz PF12171.3 ESA16532.1 - 0.11 12.6 6.2 0.32 11.1 4.3 1.8 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding HBS1_N PF08938.5 ESA16532.1 - 0.12 12.5 2.8 0.17 12.0 1.0 2.0 1 1 1 2 2 2 0 HBS1 N-terminus APG6 PF04111.7 ESA16532.1 - 0.13 11.2 7.8 0.17 10.8 5.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Nup54 PF13874.1 ESA16532.1 - 0.19 11.3 5.7 0.29 10.8 3.9 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 IncA PF04156.9 ESA16532.1 - 0.29 10.7 7.7 0.41 10.2 5.3 1.2 1 0 0 1 1 1 0 IncA protein Cortex-I_coil PF09304.5 ESA16532.1 - 0.31 11.1 10.6 0.74 9.8 7.4 1.6 1 1 0 1 1 1 0 Cortexillin I, coiled coil PyrI_C PF02748.10 ESA16532.1 - 1.2 8.6 5.2 0.45 10.0 0.2 2.2 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Prefoldin_2 PF01920.15 ESA16532.1 - 1.2 8.9 11.4 0.11 12.2 4.4 1.8 2 0 0 2 2 2 0 Prefoldin subunit NTR2 PF15458.1 ESA16532.1 - 1.3 8.1 11.3 0.05 12.8 3.4 1.9 2 0 0 2 2 2 0 Nineteen complex-related protein 2 zf-CpG_bind_C PF12269.3 ESA16532.1 - 1.4 8.3 8.4 0.73 9.2 3.4 1.9 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DMPK_coil PF08826.5 ESA16532.1 - 2.5 8.0 10.5 1 9.3 3.0 2.4 1 1 1 2 2 2 0 DMPK coiled coil domain like IL5 PF02025.10 ESA16533.1 - 0.14 12.1 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Interleukin 5 Pkinase PF00069.20 ESA16534.1 - 4.7e-26 91.4 6.1 7.1e-26 90.9 2.3 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16534.1 - 7.6e-11 41.5 1.0 7.9e-10 38.2 0.7 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA16534.1 - 0.00044 19.3 0.1 0.00077 18.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA16534.1 - 0.01 15.1 0.0 0.028 13.7 0.0 1.8 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL F-box-like PF12937.2 ESA16536.1 - 1.1e-06 28.2 3.6 4.3e-06 26.3 1.8 2.5 2 0 0 2 2 2 1 F-box-like DUF4116 PF13475.1 ESA16537.1 - 1.1 8.7 4.6 0.59 9.6 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4116) TPR_11 PF13414.1 ESA16538.1 - 2.4e-39 132.8 25.4 3.5e-10 39.3 1.2 6.9 5 1 2 7 7 7 7 TPR repeat TPR_1 PF00515.23 ESA16538.1 - 4.2e-37 124.2 18.3 3.2e-09 36.0 0.0 8.9 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16538.1 - 7.3e-37 122.3 17.1 2.7e-06 26.8 0.0 10.4 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16538.1 - 7.9e-26 89.8 15.1 6.5e-05 22.7 0.7 8.1 6 2 2 8 8 8 7 Tetratricopeptide repeat Apc3 PF12895.2 ESA16538.1 - 9.2e-23 80.1 35.4 1.2e-17 63.7 5.5 5.7 4 2 1 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESA16538.1 - 2.1e-21 74.0 9.8 0.007 16.0 0.0 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16538.1 - 1.3e-20 71.8 14.4 1.7e-05 24.6 0.0 8.7 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16538.1 - 2.7e-19 69.2 7.3 1.4e-05 25.3 0.1 7.0 5 3 3 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16538.1 - 2.4e-18 66.2 1.1 5.2e-05 23.7 0.0 7.0 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16538.1 - 3.5e-18 64.4 0.2 0.025 15.1 0.0 8.8 6 1 3 9 9 8 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16538.1 - 6.3e-14 50.5 3.6 0.023 14.4 0.0 8.9 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16538.1 - 1.7e-08 34.3 16.2 5.6 7.6 0.0 9.9 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESA16538.1 - 1.9e-08 33.9 0.8 16 5.6 0.0 7.3 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.1 ESA16538.1 - 2e-06 27.0 0.3 0.0097 14.9 0.0 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA16538.1 - 0.00012 22.0 0.5 0.019 15.0 0.0 3.8 3 2 2 5 5 4 1 Tetratricopeptide repeat BTAD PF03704.12 ESA16538.1 - 0.00014 22.1 4.9 0.073 13.3 0.0 3.9 2 1 2 4 4 4 2 Bacterial transcriptional activator domain TPR_9 PF13371.1 ESA16538.1 - 0.018 14.8 0.1 5.2 7.0 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat zf-MYND PF01753.13 ESA16539.1 - 7.9e-11 41.6 12.9 2.5e-10 40.0 8.9 1.9 1 0 0 1 1 1 1 MYND finger TPR_11 PF13414.1 ESA16539.1 - 5.2e-07 29.2 0.0 0.00011 21.7 0.0 3.9 1 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 ESA16539.1 - 6e-05 22.4 3.3 0.045 13.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16539.1 - 0.0052 16.8 0.2 1.7 9.0 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16539.1 - 0.0069 16.2 0.0 0.0069 16.2 0.0 4.3 6 0 0 6 6 6 1 Tetratricopeptide repeat P22_AR_C PF10548.4 ESA16539.1 - 0.017 14.9 0.1 0.056 13.3 0.0 1.9 2 0 0 2 2 2 0 P22AR C-terminal domain TPR_8 PF13181.1 ESA16539.1 - 0.03 14.0 7.1 0.79 9.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESA16539.1 - 0.037 13.8 0.1 0.29 10.9 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16539.1 - 0.24 11.9 2.1 23 5.7 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat eRF1_1 PF03463.10 ESA16540.1 - 2.8e-49 166.0 0.2 5e-49 165.2 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 ESA16540.1 - 7.4e-33 113.7 0.3 1.1e-32 113.1 0.2 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 ESA16540.1 - 3.8e-23 81.9 0.0 1.1e-22 80.4 0.0 1.8 1 0 0 1 1 1 1 eRF1 domain 3 Bystin PF05291.6 ESA16541.1 - 3.9e-139 462.7 3.3 3.9e-139 462.7 2.3 1.8 1 1 1 2 2 2 1 Bystin DUF2624 PF11116.3 ESA16541.1 - 0.04 14.4 0.4 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) Sdh5 PF03937.11 ESA16541.1 - 1.8 8.2 7.7 1.7 8.3 0.0 3.0 3 0 0 3 3 3 0 Flavinator of succinate dehydrogenase HSP70 PF00012.15 ESA16542.1 - 2.8e-271 900.7 13.6 3.2e-271 900.5 9.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA16542.1 - 4.5e-18 64.9 0.9 7.7e-17 60.8 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.5 ESA16542.1 - 0.0063 15.3 0.3 0.32 9.7 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 ESA16542.1 - 0.021 13.9 5.0 0.2 10.7 0.1 3.0 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase DUF1043 PF06295.7 ESA16542.1 - 1.2 8.7 6.0 2.2 7.9 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Syntaxin-6_N PF09177.6 ESA16542.1 - 1.9 8.9 7.4 4.4 7.7 0.1 3.5 4 0 0 4 4 4 0 Syntaxin 6, N-terminal BTB PF00651.26 ESA16543.1 - 6.6e-19 67.9 0.1 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA16543.1 - 8e-07 28.8 1.0 1.8e-05 24.4 0.1 2.9 1 1 1 2 2 2 1 BTB And C-terminal Kelch Pkinase PF00069.20 ESA16544.1 - 1.9e-33 115.7 0.2 3.5e-33 114.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16544.1 - 1.9e-33 115.6 0.0 3.4e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA16544.1 - 3e-07 30.8 0.2 0.00013 22.4 0.0 2.8 3 0 0 3 3 3 1 Sel1 repeat Kinase-like PF14531.1 ESA16544.1 - 0.0012 17.8 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA16544.1 - 0.0017 17.4 0.0 0.0037 16.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA16544.1 - 0.016 14.5 0.0 0.037 13.3 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.20 ESA16545.1 - 6.6e-05 22.1 0.1 0.00012 21.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16545.1 - 0.012 14.6 0.1 0.024 13.6 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase DUF2095 PF09868.4 ESA16545.1 - 0.11 12.2 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) Big_5 PF13205.1 ESA16546.1 - 0.00032 21.2 0.6 0.0011 19.5 0.4 1.9 1 0 0 1 1 1 1 Bacterial Ig-like domain US22 PF02393.11 ESA16548.1 - 0.057 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 US22 like DUF2246 PF10229.4 ESA16549.1 - 1.1e-17 64.3 0.0 1.1e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2246) MDM31_MDM32 PF08118.6 ESA16549.1 - 0.14 10.5 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Sel1 PF08238.7 ESA16551.1 - 1e-10 41.9 11.7 0.013 16.1 0.0 5.8 5 0 0 5 5 5 3 Sel1 repeat TPR_12 PF13424.1 ESA16551.1 - 0.0017 18.2 8.5 0.058 13.3 0.6 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16551.1 - 0.0067 16.2 2.0 0.0067 16.2 1.4 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16551.1 - 0.0073 15.8 1.8 0.0073 15.8 1.2 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16551.1 - 0.0091 16.5 3.3 0.58 10.9 0.2 4.0 4 1 1 5 5 4 1 Tetratricopeptide repeat RPN7 PF10602.4 ESA16551.1 - 0.017 14.5 0.5 0.017 14.5 0.4 2.4 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_6 PF13174.1 ESA16551.1 - 0.046 14.1 9.5 17 6.1 0.6 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Smr PF01713.16 ESA16551.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Smr domain TPR_16 PF13432.1 ESA16551.1 - 0.13 12.9 5.8 6.6 7.5 1.6 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16551.1 - 0.16 11.8 13.4 0.86 9.5 2.3 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA16551.1 - 0.33 10.6 14.0 0.18 11.4 1.4 3.7 3 1 1 4 4 4 0 TPR repeat TPR_8 PF13181.1 ESA16551.1 - 4.3 7.3 20.7 1.4 8.8 1.2 5.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Cortex-I_coil PF09304.5 ESA16552.1 - 0.21 11.6 7.8 0.5 10.4 4.7 2.2 1 1 0 1 1 1 0 Cortexillin I, coiled coil CPSase_L_D3 PF02787.14 ESA16552.1 - 0.36 10.6 7.6 0.22 11.2 0.2 3.0 2 2 1 4 4 4 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Pkinase PF00069.20 ESA16554.1 - 0.00019 20.6 0.0 0.00019 20.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16554.1 - 0.016 14.2 0.1 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA16556.1 - 1.7e-40 138.7 0.0 2.5e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16556.1 - 1.6e-33 115.9 0.0 3.3e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA16556.1 - 2.5e-21 75.6 0.0 1.9e-06 28.2 0.0 3.7 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ESA16556.1 - 2.2e-05 24.6 1.4 6.7 7.4 0.0 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat Kinase-like PF14531.1 ESA16556.1 - 4.5e-05 22.5 0.0 7.3e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like TPR_16 PF13432.1 ESA16556.1 - 7e-05 23.3 1.1 0.1 13.3 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA16556.1 - 0.0017 17.9 1.3 0.25 11.0 0.0 3.0 1 1 2 3 3 3 1 TPR repeat TPR_8 PF13181.1 ESA16556.1 - 0.048 13.4 3.6 8.8 6.3 0.1 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16556.1 - 0.067 13.1 3.9 1.5 8.7 0.2 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16556.1 - 0.1 12.5 7.3 4.7 7.3 0.5 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat GLTSCR1 PF15249.1 ESA16557.1 - 2.1e-21 76.0 6.7 1.1e-20 73.7 0.3 2.7 2 0 0 2 2 2 2 Glioma tumor suppressor candidate region WD40 PF00400.27 ESA16558.1 - 1.3e-61 202.4 20.6 2.4e-10 39.8 0.3 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA16558.1 - 0.0066 14.6 3.3 0.23 9.5 0.2 3.4 1 1 2 3 3 3 2 Nucleoporin Nup120/160 CLTH PF10607.4 ESA16558.1 - 0.016 14.8 0.1 0.034 13.8 0.1 1.5 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain BBS2_Mid PF14783.1 ESA16558.1 - 0.035 13.8 2.6 1.5 8.6 0.0 4.2 3 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Mito_carr PF00153.22 ESA16559.1 - 2.6e-11 43.0 0.0 4.6e-11 42.2 0.0 1.4 1 1 0 1 1 1 1 Mitochondrial carrier protein Mito_carr PF00153.22 ESA16560.1 - 8.6e-67 220.9 3.7 5.9e-25 86.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DOMON PF03351.12 ESA16561.1 - 0.053 13.4 0.1 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 DOMON domain Dimer_Tnp_hAT PF05699.9 ESA16562.1 - 7e-08 31.9 0.0 2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3255 PF11631.3 ESA16563.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3255) YL1 PF05764.8 ESA16563.1 - 6.2 6.3 5.9 7.4 6.1 4.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Pkinase PF00069.20 ESA16564.1 - 1.3e-34 119.5 0.4 1.6e-34 119.2 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16564.1 - 1.2e-33 116.3 0.1 1.3e-33 116.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA16564.1 - 2.9e-06 26.6 1.2 4.2e-06 26.1 0.8 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA16564.1 - 1.6e-05 24.7 0.5 0.01 15.6 0.2 2.6 2 1 0 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.17 ESA16564.1 - 7.9e-05 22.0 0.4 0.003 16.9 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA16564.1 - 0.0012 17.9 0.1 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RQC PF09382.5 ESA16564.1 - 0.046 13.4 0.5 8.9 6.0 0.0 3.0 1 1 2 3 3 3 0 RQC domain YrbL-PhoP_reg PF10707.4 ESA16564.1 - 0.048 12.9 0.1 0.14 11.4 0.1 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA16564.1 - 0.087 11.7 0.0 0.42 9.5 0.0 1.8 2 0 0 2 2 2 0 Kinase-like DUF1070 PF06376.7 ESA16564.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1070) dTDP_sugar_isom PF00908.12 ESA16565.1 - 0.019 14.2 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 dTDP-4-dehydrorhamnose 3,5-epimerase NAD_binding_6 PF08030.7 ESA16565.1 - 0.14 12.0 1.4 0.17 11.7 0.9 1.2 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Pkinase_Tyr PF07714.12 ESA16566.1 - 8e-47 159.4 0.0 1.4e-46 158.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16566.1 - 1.6e-44 152.0 0.4 2.8e-44 151.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA16566.1 - 1.4e-42 143.1 11.1 1.9e-10 41.0 0.3 5.5 5 0 0 5 5 5 5 Sel1 repeat Kinase-like PF14531.1 ESA16566.1 - 3.2e-06 26.3 0.0 0.00017 20.6 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA16566.1 - 0.0093 15.7 0.1 0.017 14.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA16566.1 - 0.017 14.1 0.1 0.032 13.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIT PF04212.13 ESA16566.1 - 0.053 13.4 5.4 0.39 10.6 0.2 3.7 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain BTB PF00651.26 ESA16567.1 - 0.00015 21.6 0.2 0.00045 20.1 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA16567.1 - 0.00022 21.2 0.6 0.11 12.4 0.1 2.4 1 1 1 2 2 2 2 TLD BACK PF07707.10 ESA16567.1 - 0.047 13.5 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch Laminin_G_3 PF13385.1 ESA16568.1 - 4.9e-15 56.1 0.0 1.1e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA16568.1 - 3.6e-07 29.8 0.0 5.8e-05 22.7 0.0 2.2 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA16568.1 - 0.00027 20.0 0.0 0.0034 16.4 0.0 2.2 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF316 PF03761.10 ESA16568.1 - 0.033 13.5 0.1 0.061 12.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF316) TFIIS_M PF07500.9 ESA16569.1 - 1.6e-30 105.4 1.3 2.3e-30 105.0 0.2 1.8 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 ESA16569.1 - 2.9e-19 68.3 5.7 4.5e-19 67.7 4.0 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 ESA16569.1 - 9.4e-13 47.4 0.2 1.9e-12 46.4 0.1 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain SF-assemblin PF06705.6 ESA16569.1 - 0.059 12.5 1.0 0.18 10.9 0.1 2.1 2 0 0 2 2 2 0 SF-assemblin/beta giardin PBP PF01161.15 ESA16570.1 - 2.6e-25 88.9 0.1 5.3e-25 87.9 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylethanolamine-binding protein Bac_DnaA PF00308.13 ESA16571.1 - 0.00067 19.3 0.0 0.00081 19.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial dnaA protein IstB_IS21 PF01695.12 ESA16571.1 - 0.017 14.5 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 IstB-like ATP binding protein PIF1 PF05970.9 ESA16571.1 - 0.026 13.4 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase Arch_ATPase PF01637.13 ESA16571.1 - 0.031 13.9 0.0 0.038 13.6 0.0 1.1 1 0 0 1 1 1 0 Archaeal ATPase AAA_10 PF12846.2 ESA16571.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.13 ESA16571.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family Phage_min_cap2 PF06152.6 ESA16572.1 - 0.023 13.7 0.1 0.028 13.4 0.1 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 DUF4419 PF14388.1 ESA16574.1 - 2.5e-81 273.1 0.2 3.3e-81 272.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) BpuSI_N PF15516.1 ESA16576.1 - 0.042 13.5 0.0 0.045 13.4 0.0 1.0 1 0 0 1 1 1 0 BpuSI N-terminal domain BTB PF00651.26 ESA16577.1 - 1.6e-18 66.7 0.2 3.4e-18 65.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16577.1 - 1.8e-07 31.1 5.7 3.7e-07 30.2 1.6 2.4 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA16577.1 - 8.1e-05 22.4 5.6 0.024 14.4 0.7 3.5 1 1 2 3 3 3 2 BTB And C-terminal Kelch F-box-like PF12937.2 ESA16579.1 - 4.8e-05 22.9 1.7 4.8e-05 22.9 1.2 2.5 2 0 0 2 2 2 1 F-box-like Exo_endo_phos PF03372.18 ESA16581.1 - 2.4e-25 89.8 0.0 2.9e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA16581.1 - 1e-08 34.8 0.0 1.6e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase IBR PF01485.16 ESA16582.1 - 9.3e-20 70.2 36.6 3.9e-10 39.4 6.6 4.2 3 1 1 4 4 4 3 IBR domain zf-C3HC4_2 PF13923.1 ESA16582.1 - 0.0063 16.5 7.6 0.0063 16.5 5.3 4.0 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA16582.1 - 0.017 14.8 6.8 0.017 14.8 4.7 4.2 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA16582.1 - 0.021 14.6 5.2 0.021 14.6 3.6 3.5 2 1 1 3 3 3 0 Ring finger domain RNaseH_C PF09293.5 ESA16582.1 - 0.053 13.4 0.0 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 T4 RNase H, C terminal zf-TRAF PF02176.13 ESA16582.1 - 0.38 11.1 0.2 0.38 11.1 0.1 4.4 2 2 2 4 4 4 0 TRAF-type zinc finger zf-RING_5 PF14634.1 ESA16582.1 - 3.1 7.6 36.5 0.61 9.8 8.7 4.0 3 2 0 3 3 3 0 zinc-RING finger domain DUF2325 PF10087.4 ESA16582.1 - 4.6 7.1 6.5 5.1 7.0 0.4 3.2 2 2 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2325) ubiquitin PF00240.18 ESA16583.1 - 2.7e-15 55.5 6.1 1.7e-13 49.7 1.7 2.1 2 0 0 2 2 2 2 Ubiquitin family Ubiquitin_2 PF14560.1 ESA16583.1 - 0.00013 22.1 3.8 0.0027 17.9 0.8 2.2 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD PF11976.3 ESA16583.1 - 0.00017 21.2 5.6 0.0004 20.0 1.3 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like UN_NPL4 PF11543.3 ESA16583.1 - 0.0057 16.9 2.1 0.046 14.0 0.3 2.2 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 Telomere_Sde2 PF13019.1 ESA16583.1 - 0.032 13.9 0.4 2.3 7.9 0.1 2.0 2 0 0 2 2 2 0 Telomere stability and silencing DUF972 PF06156.8 ESA16583.1 - 0.043 14.1 0.4 0.065 13.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ESA16583.1 - 0.057 13.7 0.8 0.098 12.9 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF904) PI3K_rbd PF00794.13 ESA16583.1 - 0.85 9.5 3.4 12 5.9 0.1 2.3 1 1 0 2 2 2 0 PI3-kinase family, ras-binding domain DUF2177 PF09945.4 ESA16584.1 - 0.052 13.5 0.2 0.081 12.9 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2177) DUF4131 PF13567.1 ESA16584.1 - 0.11 11.8 0.3 0.16 11.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YajC PF02699.10 ESA16584.1 - 0.23 11.1 1.3 0.46 10.1 0.9 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit DUF4064 PF13273.1 ESA16584.1 - 0.4 10.8 5.0 1.2 9.2 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SPRY PF00622.23 ESA16585.1 - 8.3e-12 45.2 0.2 9.9e-12 45.0 0.1 1.1 1 0 0 1 1 1 1 SPRY domain Sugar_tr PF00083.19 ESA16588.1 - 5.7e-96 321.8 18.6 1.5e-52 178.7 2.1 2.0 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 ESA16588.1 - 1.4e-32 112.7 14.1 1.4e-32 112.7 9.8 1.5 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 ESA16588.1 - 0.00039 18.9 18.0 0.01 14.2 3.2 3.0 2 2 0 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.8 ESA16588.1 - 0.002 16.3 9.0 0.0052 14.9 2.9 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector zf-LITAF-like PF10601.4 ESA16589.1 - 4e-22 77.8 11.6 5e-22 77.5 8.1 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain DUF164 PF02591.10 ESA16589.1 - 0.0012 18.5 0.6 1.5 8.6 0.1 2.4 2 0 0 2 2 2 2 Putative zinc ribbon domain Sgf11 PF08209.6 ESA16589.1 - 0.0079 15.4 3.1 1.8 7.9 0.6 2.3 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) zf-ISL3 PF14690.1 ESA16589.1 - 0.11 12.5 3.6 4.1 7.5 0.9 2.5 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C2HC_2 PF13913.1 ESA16589.1 - 0.12 12.1 2.2 0.67 9.6 0.0 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DZR PF12773.2 ESA16589.1 - 0.12 12.2 4.8 6.5 6.6 1.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon Mut7-C PF01927.11 ESA16589.1 - 0.15 12.0 0.8 0.28 11.1 0.6 1.3 1 1 0 1 1 1 0 Mut7-C RNAse domain UPF0547 PF10571.4 ESA16589.1 - 0.61 9.8 10.8 0.99 9.1 0.5 3.3 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 RecR PF02132.10 ESA16589.1 - 1.1 8.7 4.1 1.3 8.5 0.9 2.2 2 0 0 2 2 2 0 RecR protein SEO_C PF14577.1 ESA16589.1 - 1.7 7.9 4.3 4.3 6.6 0.4 2.1 2 0 0 2 2 2 0 Sieve element occlusion C-terminus zf-FPG_IleRS PF06827.9 ESA16589.1 - 3 7.5 6.6 2.1 8.0 0.4 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-TFIIB PF13453.1 ESA16589.1 - 3.8 6.7 6.9 5.7 6.2 0.2 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-LITAF-like PF10601.4 ESA16590.1 - 1.7e-21 75.8 8.8 2.3e-21 75.4 6.1 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain RecR PF02132.10 ESA16590.1 - 0.00018 20.8 1.6 0.24 10.8 0.4 2.5 2 0 0 2 2 2 2 RecR protein DUF164 PF02591.10 ESA16590.1 - 0.003 17.3 1.2 2 8.3 0.2 2.5 2 0 0 2 2 2 2 Putative zinc ribbon domain zf-ribbon_3 PF13248.1 ESA16590.1 - 0.0097 15.0 1.1 2.5 7.4 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon domain zf-ISL3 PF14690.1 ESA16590.1 - 0.025 14.5 2.0 4.9 7.2 0.1 2.4 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 UPF0547 PF10571.4 ESA16590.1 - 0.094 12.4 1.3 8.3 6.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-TFIIB PF13453.1 ESA16590.1 - 0.095 11.9 0.2 3.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger zinc_ribbon_4 PF13717.1 ESA16590.1 - 0.13 12.0 1.5 15 5.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_3 PF14369.1 ESA16590.1 - 0.15 12.0 3.8 1.7 8.6 0.1 2.4 2 0 0 2 2 2 0 zinc-finger zinc_ribbon_5 PF13719.1 ESA16590.1 - 0.16 11.5 1.6 13 5.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 ESA16590.1 - 0.29 10.9 2.5 4 7.3 0.2 2.3 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESA16590.1 - 0.61 9.6 5.9 8.6 5.9 0.9 2.5 2 0 0 2 2 2 0 zinc-ribbon domain TerY-C PF15616.1 ESA16590.1 - 1.8 8.4 6.6 90 3.0 4.6 2.2 1 1 0 1 1 1 0 TerY-C metal binding domain DNA_ligase_ZBD PF03119.11 ESA16590.1 - 2.7 7.7 5.3 7 6.4 0.2 3.0 3 1 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-LITAF-like PF10601.4 ESA16591.1 - 2.1e-10 40.2 11.4 3.1e-10 39.7 7.9 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-ribbon_3 PF13248.1 ESA16591.1 - 0.0012 18.0 0.7 0.55 9.5 0.1 2.7 2 0 0 2 2 2 2 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 ESA16591.1 - 0.39 10.5 13.6 3.2 7.6 5.6 2.5 2 1 0 2 2 2 0 PhnA Zinc-Ribbon Stm1_N PF09598.5 ESA16591.1 - 0.61 10.8 4.3 0.85 10.3 3.0 1.2 1 0 0 1 1 1 0 Stm1 zf-LITAF-like PF10601.4 ESA16593.1 - 2.5e-10 40.0 13.6 2.5e-10 40.0 9.4 1.5 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain Mec-17 PF05301.6 ESA16594.1 - 4.3e-40 136.3 0.7 6.5e-40 135.8 0.5 1.3 1 0 0 1 1 1 1 Touch receptor neuron protein Mec-17 Acetyltransf_1 PF00583.19 ESA16594.1 - 0.027 14.5 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA16594.1 - 0.037 14.1 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CAF-1_p150 PF11600.3 ESA16594.1 - 0.62 9.3 2.2 0.95 8.7 1.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Spt5_N PF11942.3 ESA16595.1 - 4.4e-05 24.0 17.0 4.4e-05 24.0 11.8 3.0 2 2 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal PPV_E1_N PF00524.13 ESA16595.1 - 0.026 14.7 6.8 0.026 14.7 4.7 2.5 1 1 1 2 2 2 0 E1 Protein, N terminal domain UPF0149 PF03695.8 ESA16595.1 - 0.32 10.8 0.0 0.32 10.8 0.0 2.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0149) ADIP PF11559.3 ESA16596.1 - 3.3e-28 98.4 4.5 3.3e-28 98.4 3.1 2.9 2 1 0 3 3 3 2 Afadin- and alpha -actinin-Binding ERM PF00769.14 ESA16596.1 - 0.025 14.1 36.4 0.021 14.3 9.5 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family TRAUB PF08164.7 ESA16596.1 - 0.026 14.6 4.1 0.11 12.6 0.0 3.1 3 0 0 3 3 3 0 Apoptosis-antagonizing transcription factor, C-terminal DUF2987 PF11205.3 ESA16596.1 - 0.21 11.2 6.7 4.3 6.9 0.9 3.2 2 2 2 4 4 4 0 Protein of unknown function (DUF2987) SAC3_GANP PF03399.11 ESA16597.1 - 4.4e-20 72.1 0.9 5.3e-20 71.8 0.6 1.0 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 ESA16597.1 - 2e-14 53.5 0.0 3.2e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 DUF3772 PF12607.3 ESA16597.1 - 0.027 14.1 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) DUF4116 PF13475.1 ESA16598.1 - 3 7.3 6.8 1.5 8.3 1.0 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4116) LBP_BPI_CETP PF01273.20 ESA16599.1 - 0.027 13.8 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain SDA1 PF05285.7 ESA16600.1 - 6.9 5.8 6.1 7.9 5.6 4.2 1.1 1 0 0 1 1 1 0 SDA1 Terminase_2 PF03592.11 ESA16602.1 - 0.093 13.0 4.4 0.12 12.7 3.1 1.1 1 0 0 1 1 1 0 Terminase small subunit AAA_33 PF13671.1 ESA16602.1 - 0.18 11.7 2.0 0.43 10.4 1.0 1.7 1 1 1 2 2 2 0 AAA domain MAP7 PF05672.6 ESA16602.1 - 0.26 10.6 18.9 0.35 10.2 13.1 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family COesterase PF00135.23 ESA16602.1 - 0.3 9.7 1.8 0.34 9.5 1.3 1.0 1 0 0 1 1 1 0 Carboxylesterase family OPT PF03169.10 ESA16603.1 - 8.1e-175 582.8 44.7 9.3e-175 582.6 31.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Proteasome PF00227.21 ESA16604.1 - 3.6e-33 114.4 0.0 4e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit CMAS PF02353.15 ESA16605.1 - 7.2e-63 212.2 0.7 8.7e-63 211.9 0.5 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 ESA16605.1 - 1.3e-10 41.2 0.0 2.6e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA16605.1 - 1.5e-05 25.3 0.0 2.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA16605.1 - 3.3e-05 24.2 0.0 5.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA16605.1 - 0.00082 18.9 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 ESA16605.1 - 0.001 18.4 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 ESA16605.1 - 0.0021 18.6 0.0 0.0047 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA16605.1 - 0.0023 17.3 0.0 0.005 16.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 ESA16605.1 - 0.01 16.1 0.1 0.029 14.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.7 ESA16605.1 - 0.014 14.8 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA16605.1 - 0.014 15.4 0.0 0.043 13.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 ESA16605.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) P2X_receptor PF00864.14 ESA16607.1 - 0.0025 16.5 0.1 0.12 11.0 0.0 2.1 2 0 0 2 2 2 2 ATP P2X receptor HTH_Tnp_Tc5 PF03221.11 ESA16608.1 - 7.1e-06 25.7 1.0 0.0061 16.3 0.1 2.6 2 1 1 3 3 3 2 Tc5 transposase DNA-binding domain FBP PF07299.6 ESA16609.1 - 0.018 14.4 1.0 0.022 14.0 0.7 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein (FBP) TMA7 PF09072.5 ESA16609.1 - 0.17 12.3 2.3 0.36 11.3 0.1 2.1 2 0 0 2 2 2 0 Translation machinery associated TMA7 TLD PF07534.11 ESA16610.1 - 3e-13 49.9 5.9 5.2e-13 49.1 4.1 1.3 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16610.1 - 9.5e-09 35.0 0.1 7.1e-08 32.2 0.1 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA16610.1 - 1.5e-07 31.4 0.2 3.8e-06 26.8 0.0 2.5 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA16611.1 - 1.4e-09 38.1 0.4 2.3e-09 37.3 0.3 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16611.1 - 1.1e-07 31.6 0.1 2e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA16611.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain PS_Dcarbxylase PF02666.10 ESA16613.1 - 1.4e-49 168.1 0.0 1.6e-49 167.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.1 ESA16613.1 - 0.0021 17.7 2.8 0.027 14.1 0.9 2.5 2 1 0 2 2 2 1 Biotin-lipoyl like Peptidase_M23 PF01551.17 ESA16613.1 - 0.086 12.8 0.1 1.1 9.3 0.0 2.2 1 1 1 2 2 2 0 Peptidase family M23 DUF2118 PF09891.4 ESA16613.1 - 0.12 12.0 0.1 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) APG5 PF04106.7 ESA16615.1 - 0.14 11.6 4.4 0.27 10.6 3.0 1.5 1 0 0 1 1 1 0 Autophagy protein Apg5 F-box-like PF12937.2 ESA16616.1 - 0.0026 17.4 0.2 0.0058 16.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA16617.1 - 0.013 15.2 0.5 0.013 15.2 0.3 1.6 2 0 0 2 2 2 0 F-box-like Borrelia_orfA PF02414.10 ESA16617.1 - 0.047 12.7 0.1 0.063 12.3 0.1 1.1 1 0 0 1 1 1 0 Borrelia ORF-A zinc_ribbon_2 PF13240.1 ESA16618.1 - 0.083 12.3 3.9 4.9 6.7 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-BED PF02892.10 ESA16618.1 - 1.9 8.2 6.1 0.13 12.0 0.3 2.1 2 0 0 2 2 2 0 BED zinc finger Metallophos PF00149.23 ESA16619.1 - 5.7e-07 29.1 0.1 7.4e-07 28.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA16619.1 - 0.022 14.5 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Sel1 PF08238.7 ESA16621.1 - 4.1e-25 87.6 13.9 3.5e-08 33.8 0.1 6.5 5 1 1 6 6 6 5 Sel1 repeat Prenyltrans_1 PF13243.1 ESA16621.1 - 2.2e-08 34.0 0.9 0.002 18.0 0.0 2.7 2 1 0 2 2 2 2 Prenyltransferase-like TPR_11 PF13414.1 ESA16621.1 - 3.5e-06 26.5 8.6 0.029 14.0 1.1 3.5 3 0 0 3 3 3 3 TPR repeat TPR_2 PF07719.12 ESA16621.1 - 2.7e-05 23.7 16.5 0.00081 19.1 0.7 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16621.1 - 2.9e-05 23.5 5.5 0.11 12.3 0.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16621.1 - 7.6e-05 22.5 5.7 0.13 12.1 2.3 3.4 2 1 0 2 2 2 2 Tetratricopeptide repeat Prenyltrans_2 PF13249.1 ESA16621.1 - 0.00015 22.1 1.2 0.73 10.2 0.0 2.8 2 1 0 2 2 2 2 Prenyltransferase-like TPR_6 PF13174.1 ESA16621.1 - 0.0036 17.6 5.6 3.4 8.3 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16621.1 - 0.0045 16.5 21.0 0.12 11.9 1.5 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat Prenyltrans PF00432.16 ESA16621.1 - 0.044 13.3 0.5 8.5 6.0 0.1 2.6 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat TPR_16 PF13432.1 ESA16621.1 - 0.046 14.4 0.1 12 6.7 0.1 3.0 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16621.1 - 0.063 13.9 0.0 5.1 8.0 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA16621.1 - 0.074 12.8 11.2 1 9.2 0.6 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16621.1 - 0.089 13.1 0.7 1.6 9.1 0.2 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA16621.1 - 0.12 12.3 0.1 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16621.1 - 0.23 11.3 23.4 0.51 10.2 1.5 4.9 3 2 1 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA16621.1 - 0.34 11.0 10.6 0.91 9.6 3.7 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1987 PF09345.5 ESA16621.1 - 0.37 10.6 9.0 1.5 8.6 0.2 3.7 4 1 1 5 5 5 0 Domain of unknown function (DUF1987) TPR_17 PF13431.1 ESA16621.1 - 0.45 10.8 4.3 44 4.6 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat Methyltransf_11 PF08241.7 ESA16622.1 - 7.6e-13 48.7 0.0 1.9e-12 47.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA16622.1 - 1.3e-11 44.5 0.0 2.1e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA16622.1 - 3.7e-11 42.8 0.2 5.9e-10 38.9 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA16622.1 - 1.8e-09 37.0 0.0 5.1e-09 35.5 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA16622.1 - 3.9e-08 33.5 0.0 1.4e-07 31.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA16622.1 - 1.9e-07 31.6 0.0 1.3e-06 28.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA16622.1 - 2.9e-07 30.8 0.0 9.7e-07 29.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA16622.1 - 1.4e-06 27.8 0.0 3e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ESA16622.1 - 4.6e-05 22.5 0.0 0.0001 21.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA16622.1 - 0.00066 19.7 0.0 0.0019 18.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESA16622.1 - 0.0042 16.1 0.0 0.0074 15.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.14 ESA16622.1 - 0.0076 16.2 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ESA16622.1 - 0.015 14.4 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase PrmA PF06325.8 ESA16622.1 - 0.063 12.3 0.0 0.13 11.3 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) DUF3535 PF12054.3 ESA16622.1 - 0.065 11.8 0.0 0.32 9.5 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3535) TehB PF03848.9 ESA16622.1 - 0.083 12.0 0.2 0.58 9.2 0.1 2.1 1 1 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.9 ESA16622.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.14 ESA16622.1 - 0.093 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AIG1 PF04548.11 ESA16623.1 - 6.7e-14 51.4 0.5 8e-14 51.2 0.4 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA16623.1 - 9.8e-09 35.1 0.3 1.5e-08 34.5 0.2 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.13 ESA16623.1 - 1.4e-06 27.5 0.8 2.2e-06 26.9 0.5 1.3 1 0 0 1 1 1 1 Septin DUF258 PF03193.11 ESA16623.1 - 4.4e-05 22.7 0.2 0.00011 21.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA16623.1 - 0.00062 19.2 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.17 ESA16623.1 - 0.00065 19.8 0.1 0.0015 18.7 0.0 1.6 2 0 0 2 2 1 1 RNA helicase ABC_tran PF00005.22 ESA16623.1 - 0.00089 19.5 0.4 0.0018 18.5 0.2 1.5 1 1 0 1 1 1 1 ABC transporter T2SE PF00437.15 ESA16623.1 - 0.0014 17.6 0.0 0.0026 16.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Mg_chelatase PF01078.16 ESA16623.1 - 0.0017 17.5 0.0 0.27 10.3 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESA16623.1 - 0.0028 17.1 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 ESA16623.1 - 0.0052 16.8 0.0 0.021 14.8 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_17 PF13207.1 ESA16623.1 - 0.0055 17.5 0.5 0.014 16.1 0.4 1.8 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 ESA16623.1 - 0.0058 17.1 0.3 0.0097 16.3 0.1 1.6 1 1 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 ESA16623.1 - 0.006 16.7 0.0 0.013 15.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA16623.1 - 0.0065 16.7 0.8 0.011 16.0 0.5 1.7 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 ESA16623.1 - 0.0067 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.13 ESA16623.1 - 0.007 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family SRPRB PF09439.5 ESA16623.1 - 0.0076 15.4 0.5 0.018 14.2 0.3 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit IstB_IS21 PF01695.12 ESA16623.1 - 0.009 15.4 0.4 0.039 13.3 0.3 1.9 1 1 0 1 1 1 1 IstB-like ATP binding protein Ras PF00071.17 ESA16623.1 - 0.011 15.1 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 Ras family DUF87 PF01935.12 ESA16623.1 - 0.024 14.4 0.7 0.061 13.1 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF87 DUF815 PF05673.8 ESA16623.1 - 0.029 13.3 0.0 0.049 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.17 ESA16623.1 - 0.035 12.9 0.3 0.056 12.2 0.2 1.4 1 1 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.7 ESA16623.1 - 0.039 13.0 0.0 0.065 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.2 ESA16623.1 - 0.04 13.3 0.2 0.068 12.5 0.1 1.3 1 1 0 1 1 1 0 AAA-like domain AAA_16 PF13191.1 ESA16623.1 - 0.05 13.5 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TFIIS_M PF07500.9 ESA16623.1 - 0.064 13.3 1.8 0.14 12.2 1.3 1.7 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain AAA PF00004.24 ESA16623.1 - 0.089 12.9 0.2 0.15 12.2 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Kelch_1 PF01344.20 ESA16623.1 - 0.12 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 Kelch motif Dynamin_N PF00350.18 ESA16623.1 - 0.15 11.8 2.1 0.32 10.7 0.3 2.2 1 1 1 2 2 2 0 Dynamin family SRP54 PF00448.17 ESA16623.1 - 0.21 10.9 1.5 4.7 6.5 0.2 2.1 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain AIG1 PF04548.11 ESA16624.1 - 2.3e-13 49.7 0.2 2.6e-13 49.5 0.2 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA16624.1 - 1.9e-08 34.2 0.3 2.1e-08 34.1 0.2 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.13 ESA16624.1 - 1.9e-07 30.3 0.8 3e-07 29.7 0.6 1.3 1 1 0 1 1 1 1 Septin DUF258 PF03193.11 ESA16624.1 - 0.00024 20.3 0.0 0.00032 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Mago_nashi PF02792.9 ESA16624.1 - 0.00044 19.9 0.2 0.0005 19.7 0.1 1.1 1 0 0 1 1 1 1 Mago nashi protein Miro PF08477.8 ESA16624.1 - 0.0008 19.8 0.2 0.0009 19.7 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 ESA16624.1 - 0.0013 18.1 0.2 0.002 17.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ras PF00071.17 ESA16624.1 - 0.0018 17.7 0.2 0.0026 17.1 0.2 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 ESA16624.1 - 0.0027 16.9 0.5 0.0076 15.4 0.4 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit T2SE PF00437.15 ESA16624.1 - 0.003 16.5 0.2 0.0061 15.4 0.1 1.5 1 1 1 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.12 ESA16624.1 - 0.0034 17.2 0.5 0.013 15.2 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function DUF87 ABC_tran PF00005.22 ESA16624.1 - 0.0036 17.6 0.1 0.0039 17.4 0.1 1.2 1 0 0 1 1 1 1 ABC transporter AAA_10 PF12846.2 ESA16624.1 - 0.009 15.4 0.1 0.017 14.5 0.1 1.4 1 1 0 1 1 1 1 AAA-like domain FtsK_SpoIIIE PF01580.13 ESA16624.1 - 0.0091 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.1 ESA16624.1 - 0.014 15.3 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.17 ESA16624.1 - 0.014 15.5 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.1 ESA16624.1 - 0.015 14.7 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ESA16624.1 - 0.016 15.3 0.0 0.018 15.2 0.0 1.2 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESA16624.1 - 0.026 14.0 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Dynamin_N PF00350.18 ESA16624.1 - 0.038 13.8 3.9 0.14 11.9 0.3 2.1 1 1 1 2 2 2 0 Dynamin family IstB_IS21 PF01695.12 ESA16624.1 - 0.045 13.1 0.1 0.069 12.5 0.1 1.4 1 1 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.8 ESA16624.1 - 0.059 12.2 0.1 0.11 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PUD PF03714.9 ESA16624.1 - 0.061 13.4 0.3 0.086 12.9 0.2 1.3 1 0 0 1 1 1 0 Bacterial pullanase-associated domain AAA_17 PF13207.1 ESA16624.1 - 0.061 14.1 0.2 0.085 13.6 0.1 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 ESA16624.1 - 0.07 13.1 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 ESA16624.1 - 0.094 12.3 0.0 0.16 11.6 0.0 1.4 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 ESA16624.1 - 0.096 12.9 0.5 0.11 12.7 0.4 1.3 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 ESA16624.1 - 0.16 12.1 1.1 0.59 10.3 0.8 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TLD PF07534.11 ESA16627.1 - 5.3e-13 49.1 1.9 1.1e-12 48.1 0.4 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA16627.1 - 6.2e-05 22.7 4.0 0.0014 18.4 0.5 3.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3440 PF11922.3 ESA16627.1 - 0.0095 15.5 0.0 0.071 12.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3440) TLD PF07534.11 ESA16628.1 - 7.9e-15 55.0 2.9 7.9e-15 55.0 2.0 2.4 3 1 0 3 3 3 1 TLD BTB PF00651.26 ESA16628.1 - 3.5e-11 43.0 0.1 6.5e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA16628.1 - 7.8e-07 28.8 1.9 0.00047 19.9 1.0 3.0 2 1 0 2 2 2 1 BTB And C-terminal Kelch OTU PF02338.14 ESA16629.1 - 6.7e-05 23.4 0.0 0.00017 22.1 0.0 1.6 1 1 0 1 1 1 1 OTU-like cysteine protease DUF2408 PF10303.4 ESA16631.1 - 0.027 14.5 0.5 0.037 14.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) MSP7_C PF12948.2 ESA16631.1 - 0.24 11.6 3.4 0.33 11.2 2.3 1.3 1 1 0 1 1 1 0 MSP7-like protein C-terminal domain zf-BED PF02892.10 ESA16632.1 - 2.4e-05 23.9 0.2 3.6e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 BED zinc finger DIT1_PvcA PF05141.7 ESA16632.1 - 0.085 12.1 0.2 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein PA26 PF04636.8 ESA16633.1 - 3.2e-106 355.7 0.0 7.9e-106 354.4 0.0 1.5 1 1 0 1 1 1 1 PA26 p53-induced protein (sestrin) Pkinase PF00069.20 ESA16634.1 - 4.1e-33 114.6 0.5 6.1e-32 110.7 0.1 2.2 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16634.1 - 1.4e-22 80.0 0.0 3e-22 78.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase ADIP PF11559.3 ESA16634.1 - 0.0002 21.2 0.4 0.00039 20.3 0.3 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.6 ESA16634.1 - 0.00037 20.1 2.9 0.0015 18.2 0.8 2.5 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF904 PF06005.7 ESA16634.1 - 0.0019 18.4 5.9 0.0053 17.0 4.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF904) Cep57_CLD PF14073.1 ESA16634.1 - 0.002 18.0 1.2 0.004 16.9 0.8 1.5 1 0 0 1 1 1 1 Centrosome localisation domain of Cep57 HAP1_N PF04849.8 ESA16634.1 - 0.0025 16.8 1.3 0.0044 16.0 0.9 1.4 1 0 0 1 1 1 1 HAP1 N-terminal conserved region FlxA PF14282.1 ESA16634.1 - 0.0025 17.7 4.2 0.0053 16.6 2.9 1.5 1 0 0 1 1 1 1 FlxA-like protein CENP-F_leu_zip PF10473.4 ESA16634.1 - 0.0028 17.5 5.4 0.0063 16.3 3.7 1.6 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.16 ESA16634.1 - 0.0034 17.2 5.7 0.0034 17.2 4.0 2.0 2 0 0 2 2 2 1 bZIP transcription factor IncA PF04156.9 ESA16634.1 - 0.0052 16.4 3.3 0.01 15.4 2.3 1.4 1 0 0 1 1 1 1 IncA protein DivIC PF04977.10 ESA16634.1 - 0.006 16.0 4.9 0.017 14.6 3.4 1.8 1 0 0 1 1 1 1 Septum formation initiator TMF_DNA_bd PF12329.3 ESA16634.1 - 0.0072 16.1 9.6 0.0072 16.1 6.6 2.2 3 0 0 3 3 2 1 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.4 ESA16634.1 - 0.0084 16.2 1.8 0.036 14.1 1.2 2.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 ESA16634.1 - 0.013 15.8 2.8 0.041 14.2 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Herpes_UL6 PF01763.11 ESA16634.1 - 0.02 13.0 1.4 0.032 12.4 1.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF641 PF04859.7 ESA16634.1 - 0.029 14.1 1.3 0.029 14.1 0.9 2.3 3 0 0 3 3 2 0 Plant protein of unknown function (DUF641) TSC22 PF01166.13 ESA16634.1 - 0.03 14.2 3.7 0.03 14.2 2.5 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family DUF3450 PF11932.3 ESA16634.1 - 0.053 12.7 1.7 0.083 12.1 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF2681 PF10883.3 ESA16634.1 - 0.057 13.6 2.5 0.15 12.3 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) CENP-H PF05837.7 ESA16634.1 - 0.061 13.4 4.0 0.17 12.1 2.8 1.8 1 0 0 1 1 1 0 Centromere protein H (CENP-H) GCR1_C PF12550.3 ESA16634.1 - 0.093 12.6 0.4 0.85 9.5 0.0 2.6 3 0 0 3 3 2 0 Transcriptional activator of glycolytic enzymes DUF3186 PF11382.3 ESA16634.1 - 0.23 10.5 1.3 0.36 9.9 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Tropomyosin_1 PF12718.2 ESA16634.1 - 0.28 11.0 10.0 0.039 13.8 4.1 1.6 2 0 0 2 2 1 0 Tropomyosin like Sipho_Gp157 PF05565.6 ESA16634.1 - 0.29 10.6 8.1 0.068 12.7 2.2 2.1 2 0 0 2 2 2 0 Siphovirus Gp157 XhlA PF10779.4 ESA16634.1 - 0.7 9.8 9.4 0.82 9.6 5.4 2.0 2 0 0 2 2 1 0 Haemolysin XhlA bZIP_2 PF07716.10 ESA16634.1 - 2.5 7.9 10.3 4.5 7.1 5.0 2.7 2 1 1 3 3 3 0 Basic region leucine zipper DUF1542 PF07564.6 ESA16636.1 - 0.0027 17.6 0.4 0.0027 17.6 0.3 1.6 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF148 PF02520.12 ESA16636.1 - 0.026 14.2 0.5 0.029 14.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 HTH_22 PF13309.1 ESA16636.1 - 0.13 12.0 0.2 0.19 11.4 0.1 1.4 1 1 0 1 1 1 0 HTH domain TLD PF07534.11 ESA16637.1 - 2.8e-11 43.5 1.2 5e-11 42.7 0.8 1.5 1 1 0 1 1 1 1 TLD Pkinase PF00069.20 ESA16641.1 - 0.0003 20.0 0.0 0.00047 19.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MIF4G_like_2 PF09090.6 ESA16641.1 - 0.067 12.4 0.1 1 8.5 0.0 2.0 2 0 0 2 2 2 0 MIF4G like HSF_DNA-bind PF00447.12 ESA16641.1 - 0.11 12.6 1.0 0.2 11.8 0.7 1.6 1 1 0 1 1 1 0 HSF-type DNA-binding F-box-like PF12937.2 ESA16642.1 - 2.1e-05 24.1 2.4 0.00023 20.7 0.5 2.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA16642.1 - 0.0093 15.6 1.5 0.12 12.0 0.1 3.1 3 0 0 3 3 3 1 F-box domain HSDR_N PF04313.9 ESA16643.1 - 0.0076 16.0 0.1 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) TPR_11 PF13414.1 ESA16644.1 - 1.6e-29 101.3 5.4 9e-10 38.0 0.0 4.2 1 1 4 5 5 5 5 TPR repeat TPR_1 PF00515.23 ESA16644.1 - 5.4e-20 70.0 0.0 2e-05 23.9 0.0 5.8 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16644.1 - 1.9e-17 61.7 0.0 0.01 15.6 0.0 5.9 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_9 PF13371.1 ESA16644.1 - 7.3e-12 44.9 0.0 0.00076 19.2 0.2 4.8 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16644.1 - 1.4e-10 41.5 0.0 0.071 13.8 0.2 4.2 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16644.1 - 1.3e-08 34.6 3.3 0.0036 17.2 1.9 4.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16644.1 - 7.4e-08 31.6 1.5 0.29 11.0 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16644.1 - 7.8e-06 26.1 3.7 0.65 10.3 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16644.1 - 2.4e-05 24.1 5.2 1.9 8.8 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA16644.1 - 0.0015 17.7 2.5 16 4.8 0.0 5.4 5 1 1 6 6 6 0 SHNi-TPR TPR_14 PF13428.1 ESA16644.1 - 0.0023 18.3 0.0 91 4.1 0.1 4.9 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA16644.1 - 0.0094 15.6 0.1 43 4.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA16644.1 - 0.025 14.6 8.8 1.1 9.4 0.4 4.2 2 1 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-RING_5 PF14634.1 ESA16644.1 - 0.075 12.7 0.2 0.22 11.2 0.1 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA16644.1 - 0.25 11.1 3.0 0.38 10.5 0.0 2.9 3 0 0 3 3 2 0 RING-type zinc-finger TLD PF07534.11 ESA16645.1 - 3.8e-12 46.3 2.3 1.2e-11 44.7 1.6 1.9 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA16645.1 - 5.2e-11 42.5 0.4 1.3e-10 41.2 0.3 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA16645.1 - 0.0003 20.5 0.3 0.0003 20.5 0.2 3.2 3 1 1 4 4 4 1 BTB And C-terminal Kelch FLYWCH PF04500.11 ESA16646.1 - 0.026 14.4 1.0 0.039 13.8 0.7 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain MSA_2 PF00985.12 ESA16646.1 - 0.078 13.1 0.8 0.11 12.6 0.5 1.3 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family DDE_1 PF03184.14 ESA16648.1 - 1.1e-06 27.9 0.0 1.2e-06 27.8 0.0 1.2 1 1 0 1 1 1 1 DDE superfamily endonuclease Sel1 PF08238.7 ESA16649.1 - 8.5e-36 121.6 10.5 1.3e-11 44.7 0.2 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ESA16649.1 - 0.014 14.9 10.5 0.13 11.9 1.4 3.4 1 1 2 3 3 3 0 TPR repeat DUF2219 PF09982.4 ESA16649.1 - 0.08 11.7 0.0 0.098 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2219) TPR_12 PF13424.1 ESA16649.1 - 0.48 10.3 7.6 11 6.0 0.1 4.0 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16649.1 - 0.65 10.3 4.1 27 5.2 0.1 4.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16649.1 - 1.6 9.3 5.3 53 4.5 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA16649.1 - 5.3 7.2 11.8 17 5.6 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat SPO22 PF08631.5 ESA16650.1 - 0.11 11.5 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF4618 PF15397.1 ESA16650.1 - 0.16 11.2 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) F-box-like PF12937.2 ESA16652.1 - 0.0012 18.5 0.9 0.0027 17.3 0.0 2.1 2 0 0 2 2 2 1 F-box-like LRR_2 PF07723.8 ESA16652.1 - 0.56 10.8 6.1 20 5.8 0.4 4.5 3 0 0 3 3 3 0 Leucine Rich Repeat Glyco_transf_64 PF09258.5 ESA16653.1 - 0.016 14.4 1.0 0.02 14.0 0.7 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 64 domain Anoctamin PF04547.7 ESA16653.1 - 0.052 12.1 2.0 0.052 12.1 0.7 1.4 1 1 0 1 1 1 0 Calcium-activated chloride channel SapB_2 PF03489.12 ESA16653.1 - 0.079 13.0 0.4 0.38 10.8 0.1 2.3 2 0 0 2 2 2 0 Saposin-like type B, region 2 RusA PF05866.6 ESA16653.1 - 0.11 12.9 0.4 0.41 11.0 0.1 1.9 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA p450 PF00067.17 ESA16654.1 - 5.4e-36 124.0 0.0 5.9e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Metallophos PF00149.23 ESA16655.1 - 2e-37 128.5 0.3 2.6e-37 128.1 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESA16655.1 - 1.5e-10 40.9 2.1 3.3e-10 39.8 0.4 2.2 2 0 0 2 2 2 1 PPP5 TPR repeat region DivIC PF04977.10 ESA16657.1 - 0.025 14.0 0.3 0.039 13.4 0.2 1.3 1 0 0 1 1 1 0 Septum formation initiator HALZ PF02183.13 ESA16657.1 - 0.075 12.7 0.5 0.76 9.5 0.4 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF3342 PF11822.3 ESA16657.1 - 0.076 12.1 0.0 0.15 11.1 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) PspB PF06667.7 ESA16657.1 - 0.079 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Phage shock protein B PUB PF09409.5 ESA16657.1 - 0.4 10.4 2.5 4.1 7.2 0.3 2.2 2 0 0 2 2 2 0 PUB domain HemY_N PF07219.8 ESA16658.1 - 0.089 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus Pkinase_Tyr PF07714.12 ESA16659.1 - 2.5e-40 138.2 0.0 3.2e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16659.1 - 3.5e-36 124.6 0.1 5.1e-35 120.8 0.1 2.4 2 1 0 2 2 2 1 Protein kinase domain Stc1 PF12898.2 ESA16659.1 - 0.087 12.8 0.1 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Stc1 domain DUF3780 PF12635.2 ESA16660.1 - 0.053 13.0 1.1 0.074 12.5 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) Retrotrans_gag PF03732.12 ESA16660.1 - 0.099 12.7 4.3 0.072 13.1 1.9 1.5 2 0 0 2 2 2 0 Retrotransposon gag protein DUF3671 PF12420.3 ESA16660.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function Imm20 PF15568.1 ESA16661.1 - 0.043 13.7 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 20 zf-PHD-like PF15446.1 ESA16662.1 - 0.022 14.0 0.3 0.087 12.1 0.0 1.7 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain EmrE PF13536.1 ESA16663.1 - 0.078 13.1 7.9 0.12 12.5 5.4 1.2 1 0 0 1 1 1 0 Multidrug resistance efflux transporter COX7C PF02935.11 ESA16663.1 - 0.5 10.1 2.1 2.4 7.9 1.5 2.2 1 1 0 1 1 1 0 Cytochrome c oxidase subunit VIIc DUF3353 PF11833.3 ESA16663.1 - 1.1 8.6 3.7 2.2 7.7 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3353) zf-RING_2 PF13639.1 ESA16664.1 - 2.8e-13 49.4 5.2 4.4e-13 48.8 3.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA16664.1 - 6.2e-10 39.0 4.3 1.2e-09 38.1 3.0 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESA16664.1 - 5.8e-07 29.0 3.7 8.7e-07 28.5 2.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA16664.1 - 4e-06 26.7 6.9 6.4e-06 26.1 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA16664.1 - 2.7e-05 23.7 8.4 4.5e-05 23.0 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA16664.1 - 0.0013 18.4 4.0 0.0066 16.2 2.8 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 ESA16664.1 - 0.0015 18.2 5.6 0.0025 17.5 3.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.3 ESA16664.1 - 0.027 14.0 3.7 0.053 13.0 2.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 ESA16664.1 - 0.046 13.3 5.1 0.079 12.5 3.5 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ribbon_3 PF13248.1 ESA16664.1 - 0.085 12.0 0.4 0.19 10.9 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Ins_beta PF03488.9 ESA16664.1 - 0.11 12.2 1.3 0.26 11.0 0.9 1.6 1 0 0 1 1 1 0 Nematode insulin-related peptide beta type zf-RING_UBOX PF13445.1 ESA16664.1 - 0.43 10.3 4.7 1.2 8.8 3.3 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.1 ESA16664.1 - 0.47 10.0 4.3 1.2 8.7 3.0 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 C2 PF00168.25 ESA16665.1 - 1.8e-33 114.2 1.9 6.4e-14 51.5 0.0 3.5 3 0 0 3 3 3 3 C2 domain UPF0444 PF15475.1 ESA16665.1 - 0.05 13.6 0.3 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Transmembrane protein C12orf23, UPF0444 DUF2072 PF09845.4 ESA16665.1 - 8.3 6.3 15.6 0.35 10.8 0.6 3.7 2 1 1 3 3 3 0 Zn-ribbon containing protein (DUF2072) C2 PF00168.25 ESA16666.1 - 4.1e-28 97.0 0.2 1.3e-15 57.0 0.0 2.4 2 0 0 2 2 2 2 C2 domain DUF2404 PF10296.4 ESA16666.1 - 4.2e-05 23.5 0.0 0.00044 20.3 0.0 2.7 3 0 0 3 3 3 1 Putative integral membrane protein conserved region (DUF2404) Dimer_Tnp_hAT PF05699.9 ESA16667.1 - 7.6e-22 76.7 0.0 1e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Noc2 PF03715.8 ESA16669.1 - 8.2e-115 382.7 0.7 1.7e-114 381.7 0.5 1.6 1 0 0 1 1 1 1 Noc2p family DUF2944 PF11161.3 ESA16670.1 - 0.24 11.0 0.0 0.99 9.0 0.0 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF2946) SAM_1 PF00536.25 ESA16671.1 - 0.024 14.8 0.0 0.027 14.6 0.0 1.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA16671.1 - 0.065 13.0 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA16672.1 - 3.2e-06 26.8 0.2 6.9e-05 22.6 0.1 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Hydrolase PF00702.21 ESA16673.1 - 8.3e-14 52.5 0.1 9.2e-11 42.5 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA16673.1 - 2.3e-13 49.8 0.1 4e-12 45.9 0.0 2.8 2 1 1 3 3 3 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 ESA16673.1 - 1.5e-12 47.0 0.4 1.5e-11 43.7 0.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase HAD PF12710.2 ESA16673.1 - 6.6e-12 45.9 0.1 4.2e-11 43.3 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA16673.1 - 0.00088 18.9 0.1 0.00088 18.9 0.1 4.1 5 0 0 5 5 5 1 haloacid dehalogenase-like hydrolase Kinesin PF00225.18 ESA16674.1 - 2.7e-92 309.0 0.1 3.1e-92 308.8 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_33 PF13671.1 ESA16674.1 - 0.074 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3647 PF12363.3 ESA16675.1 - 0.04 14.0 0.2 0.046 13.8 0.1 1.2 1 0 0 1 1 1 0 Phage protein BHD_1 PF10403.4 ESA16676.1 - 0.024 14.1 0.1 0.05 13.1 0.1 1.6 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 DUF630 PF04783.7 ESA16677.1 - 0.011 15.6 0.0 0.48 10.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF630) WXG100 PF06013.7 ESA16677.1 - 3.1 7.8 7.6 17 5.5 0.0 3.6 3 1 1 4 4 4 0 Proteins of 100 residues with WXG DUF3940 PF13076.1 ESA16680.1 - 0.054 13.0 0.8 34 4.0 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3940) F-box-like PF12937.2 ESA16682.1 - 1.1e-08 34.6 0.2 2.6e-08 33.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA16682.1 - 0.00017 21.1 0.2 0.00053 19.5 0.1 1.9 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.1 ESA16682.1 - 1.3 9.3 3.8 32 5.0 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat SPX PF03105.14 ESA16683.1 - 2.5e-15 56.9 14.3 1e-07 32.0 4.1 3.0 2 1 1 3 3 3 2 SPX domain HAD PF12710.2 ESA16683.1 - 5e-14 52.9 0.4 1.9e-13 51.0 0.0 2.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 ESA16683.1 - 4.9e-11 43.4 1.9 9.5e-10 39.2 1.3 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA16683.1 - 3e-09 36.8 0.1 3e-09 36.8 0.1 2.9 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase ACT_6 PF13740.1 ESA16683.1 - 3.2e-06 26.7 0.0 2.6e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 ACT domain Put_Phosphatase PF06888.7 ESA16683.1 - 0.00011 21.4 0.0 0.027 13.6 0.0 2.3 2 0 0 2 2 2 2 Putative Phosphatase HAD_2 PF13419.1 ESA16683.1 - 0.00052 20.2 0.0 0.0016 18.7 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase TPR_11 PF13414.1 ESA16684.1 - 9.1e-16 57.2 7.1 7.8e-13 47.8 0.2 4.0 3 1 0 4 4 4 2 TPR repeat TPR_2 PF07719.12 ESA16684.1 - 7.2e-09 34.9 14.4 0.042 13.7 0.0 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat SET PF00856.23 ESA16684.1 - 3.9e-08 33.7 0.0 3.3e-07 30.7 0.0 2.5 1 1 0 1 1 1 1 SET domain TPR_1 PF00515.23 ESA16684.1 - 1.8e-07 30.4 11.7 0.0056 16.2 0.1 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA16684.1 - 0.0002 21.7 0.1 0.73 10.6 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA16684.1 - 0.00041 20.3 4.0 0.19 12.0 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA16684.1 - 0.0009 19.8 2.4 0.81 10.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA16684.1 - 0.00097 19.2 6.5 0.0088 16.1 1.2 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 ESA16684.1 - 0.01 15.7 8.4 1.5 8.7 0.8 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA16684.1 - 0.018 15.3 1.4 11 6.3 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat PPR PF01535.15 ESA16684.1 - 0.14 12.1 0.1 28 4.9 0.0 3.3 3 0 0 3 3 3 0 PPR repeat TPR_7 PF13176.1 ESA16684.1 - 0.17 11.7 2.7 16 5.5 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16684.1 - 0.32 11.5 1.5 41 4.9 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA16684.1 - 0.34 11.0 2.2 13 5.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA16685.1 - 1.1e-239 769.7 128.3 2.4e-11 43.9 0.4 25.3 25 0 0 25 25 25 25 Sel1 repeat TPR_16 PF13432.1 ESA16685.1 - 7.5e-11 42.3 4.5 0.43 11.3 0.1 11.2 7 4 9 17 17 17 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16685.1 - 0.00043 20.5 51.0 3.8 8.1 0.0 16.5 21 1 1 22 22 22 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16685.1 - 0.5 10.3 65.2 1.1 9.3 0.0 15.1 5 3 13 19 19 19 0 Tetratricopeptide repeat Nbl1_Borealin_N PF10444.4 ESA16685.1 - 2 7.8 5.7 15 5.0 0.7 2.5 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal PDZ_1 PF12812.2 ESA16687.1 - 1.8e-31 107.8 0.0 1.3e-22 79.4 0.0 2.8 2 0 0 2 2 2 2 PDZ-like domain PDZ_2 PF13180.1 ESA16687.1 - 3.2e-20 71.7 0.2 8e-07 28.8 0.1 4.5 4 0 0 4 4 4 3 PDZ domain Trypsin_2 PF13365.1 ESA16687.1 - 1.4e-12 47.6 0.0 7.7e-10 38.8 0.0 2.8 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ PF00595.19 ESA16687.1 - 8.3e-12 45.1 0.1 0.0033 17.5 0.0 3.9 4 0 0 4 4 4 3 PDZ domain (Also known as DHR or GLGF) Trypsin PF00089.21 ESA16687.1 - 5.2e-05 22.9 0.0 0.0017 17.9 0.0 2.4 2 0 0 2 2 2 1 Trypsin Peptidase_S7 PF00949.16 ESA16687.1 - 0.049 13.0 1.5 0.13 11.6 0.6 2.0 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S29 PF02907.10 ESA16687.1 - 0.075 12.5 0.1 0.43 10.0 0.0 2.2 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease Peptidase_S3 PF00944.14 ESA16687.1 - 0.078 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Alphavirus core protein Peptidase_S46 PF10459.4 ESA16687.1 - 0.16 10.3 0.1 0.31 9.3 0.1 1.4 1 0 0 1 1 1 0 Peptidase S46 BTB PF00651.26 ESA16688.1 - 4.4e-21 74.9 0.1 6.7e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA16688.1 - 0.019 14.1 0.1 0.02 14.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Skp1_POZ PF03931.10 ESA16688.1 - 0.069 13.2 0.6 0.35 11.0 0.0 2.4 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain Urm1 PF09138.6 ESA16688.1 - 0.078 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Bcl-2 PF00452.14 ESA16688.1 - 0.088 12.9 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family DUF2956 PF11169.3 ESA16689.1 - 0.09 12.7 4.5 0.11 12.4 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Peptidase_S49_N PF08496.5 ESA16689.1 - 0.17 11.6 3.5 0.19 11.5 2.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CAF-1_p150 PF11600.3 ESA16689.1 - 0.24 10.7 14.5 0.28 10.5 10.1 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF1764 PF08576.5 ESA16689.1 - 0.46 11.3 4.5 0.5 11.1 3.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3464 PF11947.3 ESA16689.1 - 0.75 9.2 3.4 0.84 9.0 2.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) BRF1 PF07741.8 ESA16689.1 - 1.6 8.9 8.9 2 8.6 6.2 1.1 1 0 0 1 1 1 0 Brf1-like TBP-binding domain KOG2701 PF09762.4 ESA16689.1 - 2.3 8.2 5.3 2.6 8.0 3.7 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) FimP PF09766.4 ESA16689.1 - 7 5.6 9.1 10 5.0 6.3 1.3 1 1 0 1 1 1 0 Fms-interacting protein DUF4337 PF14235.1 ESA16689.1 - 7.7 6.3 6.4 8.8 6.1 4.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Pkinase_Tyr PF07714.12 ESA16691.1 - 1.5e-23 83.2 0.0 1.8e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16691.1 - 2.1e-19 69.7 0.0 2.8e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DDE_3 PF13358.1 ESA16692.1 - 1.6e-06 27.9 0.2 1.6e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2002 PF09400.5 ESA16693.1 - 0.049 13.3 0.1 0.051 13.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2002) CBAH PF02275.13 ESA16693.1 - 0.065 12.6 0.0 0.07 12.5 0.0 1.0 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family Myb_DNA-bind_6 PF13921.1 ESA16694.1 - 2.7e-36 123.4 0.1 3.6e-15 55.8 0.0 4.0 2 1 2 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA16694.1 - 3.1e-36 123.1 4.8 7.9e-13 48.2 0.1 4.1 4 1 0 4 4 4 3 Myb-like DNA-binding domain Rap1_C PF11626.3 ESA16694.1 - 8.9e-07 28.7 1.0 0.16 11.8 0.0 3.2 2 1 1 3 3 3 3 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_4 PF13837.1 ESA16694.1 - 6.5e-05 22.9 1.7 0.066 13.3 0.0 3.6 3 1 0 3 3 3 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA16694.1 - 0.049 13.5 3.2 25 4.8 0.0 4.8 5 2 1 6 6 6 0 Myb/SANT-like DNA-binding domain SnoaL PF07366.7 ESA16698.1 - 0.0097 15.4 0.0 0.01 15.4 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Skp1_POZ PF03931.10 ESA16698.1 - 0.017 15.2 0.3 0.027 14.5 0.2 1.3 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Kinesin PF00225.18 ESA16699.1 - 8.5e-94 313.9 0.7 8.5e-94 313.9 0.5 1.5 2 0 0 2 2 2 1 Kinesin motor domain DUF2513 PF10711.4 ESA16699.1 - 0.077 13.0 1.4 0.19 11.8 1.0 1.7 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) Ribosomal_L27e PF01777.13 ESA16699.1 - 1.1 9.4 4.8 17 5.6 0.0 2.7 2 0 0 2 2 2 0 Ribosomal L27e protein family Histone PF00125.19 ESA16700.1 - 3.1e-23 81.6 0.1 4.3e-23 81.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA16700.1 - 2.3e-06 27.5 0.0 4.7e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 ESA16700.1 - 0.00077 19.6 0.0 0.0013 18.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 ESA16700.1 - 0.015 14.0 0.2 0.018 13.6 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1018 PF06252.7 ESA16700.1 - 0.031 14.7 0.1 0.041 14.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) RNA_pol_Rpb2_1 PF04563.10 ESA16700.1 - 0.28 10.0 3.3 3.1 6.6 0.8 2.0 1 1 1 2 2 2 0 RNA polymerase beta subunit FAD_binding_4 PF01565.18 ESA16705.1 - 3e-08 33.2 0.0 5.9e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 ESA16705.1 - 3.1e-08 33.5 0.0 6.3e-08 32.5 0.0 1.5 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FF PF01846.14 ESA16705.1 - 0.16 11.9 1.6 20 5.2 0.1 3.3 4 0 0 4 4 4 0 FF domain DDE_Tnp_IS66 PF03050.9 ESA16707.1 - 0.047 12.8 0.0 0.083 12.0 0.0 1.3 1 0 0 1 1 1 0 Transposase IS66 family Mhr1 PF12829.2 ESA16707.1 - 0.085 12.6 0.1 0.23 11.2 0.1 1.8 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Kri1 PF05178.7 ESA16707.1 - 2.4 8.5 5.7 0.16 12.2 0.4 1.8 2 0 0 2 2 2 0 KRI1-like family Tropomyosin_1 PF12718.2 ESA16709.1 - 0.0005 19.9 12.1 0.0005 19.9 8.4 3.2 1 1 1 2 2 2 1 Tropomyosin like ATG16 PF08614.6 ESA16709.1 - 0.034 13.9 40.2 0.28 10.9 9.7 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HlyD PF00529.15 ESA16709.1 - 0.059 12.6 19.2 0.085 12.1 13.3 1.2 1 0 0 1 1 1 0 HlyD family secretion protein DUF1633 PF07794.6 ESA16709.1 - 0.21 9.5 3.9 0.25 9.2 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) SlyX PF04102.7 ESA16709.1 - 0.5 10.7 28.0 0.46 10.8 6.1 3.7 1 1 1 3 3 3 0 SlyX DUF812 PF05667.6 ESA16709.1 - 0.66 8.4 26.1 0.92 7.9 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) TMF_DNA_bd PF12329.3 ESA16709.1 - 0.83 9.5 44.6 0.04 13.7 9.0 4.1 2 1 3 5 5 5 0 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.7 ESA16709.1 - 1.4 8.6 43.4 0.98 9.1 20.5 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CCDC155 PF14662.1 ESA16709.1 - 2.2 7.8 34.9 2.8 7.4 24.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 ADIP PF11559.3 ESA16709.1 - 8.7 6.2 41.6 0.66 9.8 13.0 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding MreB_Mbl PF06723.8 ESA16710.1 - 8.7e-05 21.2 0.0 0.017 13.7 0.0 2.5 2 0 0 2 2 2 2 MreB/Mbl protein Reo_sigmaC PF04582.7 ESA16710.1 - 0.79 8.8 9.7 0.53 9.3 4.5 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein ATP-synt_8 PF00895.15 ESA16711.1 - 1.5 9.1 4.6 0.49 10.6 0.8 2.0 2 0 0 2 2 2 0 ATP synthase protein 8 DivIC PF04977.10 ESA16712.1 - 0.0046 16.4 9.6 0.0086 15.5 2.4 2.3 1 1 1 2 2 2 1 Septum formation initiator TSC22 PF01166.13 ESA16712.1 - 0.012 15.5 9.3 0.8 9.7 1.7 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family PspA_IM30 PF04012.7 ESA16712.1 - 0.024 13.9 1.6 0.033 13.5 1.1 1.2 1 0 0 1 1 1 0 PspA/IM30 family bZIP_1 PF00170.16 ESA16712.1 - 0.027 14.4 9.6 0.053 13.4 3.4 2.3 1 1 1 2 2 2 0 bZIP transcription factor BLOC1_2 PF10046.4 ESA16712.1 - 0.046 13.8 7.0 0.082 13.0 4.8 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.2 ESA16712.1 - 0.053 13.3 8.1 0.1 12.4 5.6 1.5 1 0 0 1 1 1 0 Tropomyosin like APG6 PF04111.7 ESA16712.1 - 0.098 11.6 6.4 0.18 10.7 4.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF904 PF06005.7 ESA16712.1 - 0.11 12.7 10.1 5.5 7.3 7.0 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Spc7 PF08317.6 ESA16712.1 - 0.13 10.9 4.9 0.17 10.5 3.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Rootletin PF15035.1 ESA16712.1 - 0.14 12.1 7.9 0.23 11.3 5.5 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion IncA PF04156.9 ESA16712.1 - 0.14 11.7 3.5 0.23 11.0 2.4 1.3 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 ESA16712.1 - 0.22 11.3 7.4 0.11 12.3 1.3 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding ERM PF00769.14 ESA16712.1 - 0.31 10.5 6.9 0.55 9.7 4.7 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family bZIP_2 PF07716.10 ESA16712.1 - 0.36 10.6 10.1 1.8 8.4 3.8 2.3 1 1 1 2 2 2 0 Basic region leucine zipper DivIVA PF05103.8 ESA16712.1 - 0.41 10.7 5.1 0.8 9.7 3.6 1.5 1 0 0 1 1 1 0 DivIVA protein HR1 PF02185.11 ESA16712.1 - 0.83 9.4 6.5 0.71 9.6 2.4 2.3 2 1 0 2 2 2 0 Hr1 repeat CCDC92 PF14916.1 ESA16712.1 - 0.9 9.1 3.9 3.8 7.1 1.5 2.3 1 1 1 2 2 2 0 Coiled-coil domain of unknown function Tup_N PF08581.5 ESA16712.1 - 1.2 9.4 7.4 0.83 9.8 3.8 1.7 2 0 0 2 2 1 0 Tup N-terminal Spc24 PF08286.6 ESA16712.1 - 1.6 8.4 7.5 0.56 9.9 3.4 1.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF972 PF06156.8 ESA16712.1 - 1.6 9.1 9.0 3.2 8.1 4.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF972) NYD-SP28_assoc PF14775.1 ESA16712.1 - 5.6 6.7 9.2 3.7 7.3 1.6 2.3 2 0 0 2 2 2 0 Sperm tail C-terminal domain RSD-2 PF07547.8 ESA16714.1 - 0.064 13.4 0.1 0.064 13.4 0.0 2.4 2 0 0 2 2 2 0 RSD-2 N-terminal domain Laminin_II PF06009.7 ESA16714.1 - 0.19 11.4 7.9 0.49 10.1 5.5 1.6 1 0 0 1 1 1 0 Laminin Domain II MreB_Mbl PF06723.8 ESA16714.1 - 0.2 10.2 0.0 5.5 5.4 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein Mnd1 PF03962.10 ESA16714.1 - 0.55 9.8 11.3 0.24 11.0 5.7 1.9 2 0 0 2 2 2 0 Mnd1 family BLOC1_2 PF10046.4 ESA16714.1 - 4.7 7.4 15.4 0.75 9.9 6.6 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 ESA16714.1 - 6.2 6.3 9.3 13 5.3 6.5 1.4 1 0 0 1 1 1 0 IncA protein Fib_alpha PF08702.5 ESA16714.1 - 8.6 6.4 11.2 1.6 8.8 4.9 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Aminotran_1_2 PF00155.16 ESA16716.1 - 7.7e-84 281.7 0.0 8.8e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Citrate_synt PF00285.16 ESA16717.1 - 1.1e-17 63.8 0.0 3.6e-16 58.8 0.0 2.5 1 1 1 2 2 2 1 Citrate synthase Ligase_CoA PF00549.14 ESA16717.1 - 7.6e-17 61.3 0.0 1.5e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.14 ESA16717.1 - 1.6e-11 44.5 0.0 5.5e-11 42.8 0.0 2.0 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.5 ESA16717.1 - 3.8e-09 36.2 0.0 7.2e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.1 ESA16717.1 - 4e-05 23.2 0.0 0.00034 20.2 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain SF3a60_bindingd PF12108.3 ESA16719.1 - 1.8e-12 46.5 0.2 3.1e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain ApbA_C PF08546.6 ESA16719.1 - 0.0033 17.3 0.2 0.0055 16.6 0.0 1.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal DUF3939 PF13075.1 ESA16719.1 - 0.056 13.1 0.1 0.093 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) Matrilin_ccoil PF10393.4 ESA16719.1 - 0.075 12.4 0.3 0.15 11.4 0.2 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin BBP1_C PF15272.1 ESA16719.1 - 0.44 10.0 4.5 0.58 9.6 1.8 2.1 1 1 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF4511 PF14974.1 ESA16720.1 - 0.05 13.3 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4511) DUF3782 PF12644.2 ESA16720.1 - 0.067 12.9 0.0 0.7 9.7 0.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) TLD PF07534.11 ESA16721.1 - 1.9e-12 47.3 0.7 3.5e-12 46.4 0.5 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA16723.1 - 7.4e-19 67.7 0.0 1.8e-18 66.5 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA16723.1 - 0.0023 17.7 0.4 0.0055 16.5 0.1 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3954 PF13128.1 ESA16723.1 - 0.076 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3954) SBP_bac_7 PF03480.8 ESA16723.1 - 0.18 10.9 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 ESCRT-II PF05871.7 ESA16724.1 - 0.02 14.8 2.1 0.026 14.4 1.4 1.2 1 0 0 1 1 1 0 ESCRT-II complex subunit Adeno_E1A PF02703.9 ESA16724.1 - 0.043 13.2 4.8 0.64 9.4 0.5 2.0 1 1 1 2 2 2 0 Early E1A protein LIM_bind PF01803.11 ESA16724.1 - 0.056 12.5 5.1 0.17 10.9 0.3 2.0 1 1 1 2 2 2 0 LIM-domain binding protein AAA-ATPase_like PF09820.4 ESA16724.1 - 0.07 12.2 2.5 0.1 11.7 1.8 1.2 1 0 0 1 1 1 0 Predicted AAA-ATPase DUF572 PF04502.8 ESA16726.1 - 1.5e-93 313.5 7.2 1.9e-93 313.2 5.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Lar_restr_allev PF14354.1 ESA16726.1 - 0.033 14.4 0.9 2.3 8.6 1.1 2.3 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-FCS PF06467.9 ESA16726.1 - 0.077 12.6 1.0 0.21 11.2 0.1 2.0 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-ribbon_3 PF13248.1 ESA16726.1 - 0.22 10.7 1.1 9 5.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin PF00301.15 ESA16726.1 - 0.32 10.9 2.6 1.3 8.9 1.8 2.0 1 1 0 1 1 1 0 Rubredoxin zf-FPG_IleRS PF06827.9 ESA16726.1 - 0.35 10.5 1.8 7.4 6.3 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-dskA_traR PF01258.12 ESA16726.1 - 0.42 10.3 2.1 0.49 10.1 0.2 1.9 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger SET PF00856.23 ESA16727.1 - 1.1e-07 32.3 0.0 0.0076 16.5 0.0 2.1 2 0 0 2 2 2 2 SET domain DUF3173 PF11372.3 ESA16727.1 - 0.018 14.6 0.0 0.065 12.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3173) DSPc PF00782.15 ESA16728.1 - 8.2e-36 122.5 0.0 1.3e-35 121.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 ESA16728.1 - 0.0055 16.0 0.0 0.0083 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 ESA16728.1 - 0.013 15.7 0.0 0.62 10.2 0.0 2.3 1 1 1 2 2 2 0 Tyrosine phosphatase family DUF2963 PF11178.3 ESA16729.1 - 0.29 10.5 2.7 6.3 6.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2963) Sel1 PF08238.7 ESA16730.1 - 2.4e-17 62.9 5.8 8e-08 32.6 0.1 3.1 3 0 0 3 3 3 3 Sel1 repeat HypA PF01155.14 ESA16731.1 - 0.015 14.9 0.5 0.021 14.4 0.4 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF3991 PF13154.1 ESA16731.1 - 0.067 13.3 1.0 0.14 12.3 0.3 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3991) Phage_int_SAM_1 PF02899.12 ESA16733.1 - 0.073 13.2 0.5 2.2 8.5 0.2 2.9 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Retrotrans_gag PF03732.12 ESA16733.1 - 0.17 11.9 5.2 2.9 8.0 0.1 3.5 2 1 1 3 3 3 0 Retrotransposon gag protein DUF2497 PF10691.4 ESA16733.1 - 1.6 8.7 7.0 10 6.2 0.2 3.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2497) Pox_vIL-18BP PF05566.7 ESA16734.1 - 0.059 13.3 0.2 0.059 13.3 0.1 1.0 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein Pentapeptide_4 PF13599.1 ESA16736.1 - 0.18 11.6 3.1 0.41 10.4 1.1 2.2 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) Ribosomal_L5_C PF00673.16 ESA16737.1 - 4.7e-23 80.7 0.0 6.8e-23 80.2 0.0 1.2 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 ESA16737.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L5 Ribosomal_L19 PF01245.15 ESA16738.1 - 2.5e-25 88.4 0.1 3.7e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 PAT1 PF09770.4 ESA16740.1 - 7.8e-175 583.4 4.0 2e-156 522.5 0.0 2.0 1 1 0 2 2 2 2 Topoisomerase II-associated protein PAT1 NARG2_C PF10505.4 ESA16741.1 - 0.089 11.9 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus Med10 PF09748.4 ESA16742.1 - 6.7e-23 80.9 1.0 9.8e-23 80.3 0.7 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Amdo_NSP PF12475.3 ESA16742.1 - 0.0036 17.1 0.1 0.0093 15.8 0.1 1.7 1 0 0 1 1 1 1 Amdovirus non-structural protein DUF3969 PF13108.1 ESA16742.1 - 0.014 15.0 0.7 0.061 12.9 0.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3969) GrpE PF01025.14 ESA16743.1 - 1.4e-50 171.1 0.9 1.7e-50 170.8 0.6 1.0 1 0 0 1 1 1 1 GrpE Erf4 PF10256.4 ESA16744.1 - 0.015 15.1 0.5 0.016 15.0 0.4 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family E1-E2_ATPase PF00122.15 ESA16745.1 - 9.9e-14 50.9 0.0 2.1e-13 49.8 0.0 1.6 1 1 0 1 1 1 1 E1-E2 ATPase ComK PF06338.6 ESA16746.1 - 0.26 10.7 2.9 0.46 9.9 0.8 1.9 1 1 0 2 2 2 0 ComK protein RNase_H PF00075.19 ESA16752.1 - 1e-07 32.3 0.0 1.7e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 RNase H Imm8 PF15560.1 ESA16752.1 - 0.0011 18.6 5.1 0.0043 16.7 0.7 2.4 1 1 1 2 2 2 2 Immunity protein 8 DNA_pack_C PF02499.10 ESA16752.1 - 0.0024 16.6 0.2 0.0031 16.3 0.1 1.2 1 0 0 1 1 1 1 Probable DNA packing protein, C-terminus Borrelia_REV PF03978.8 ESA16754.1 - 0.041 13.6 2.8 0.06 13.0 1.9 1.3 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein DUF4550 PF15084.1 ESA16756.1 - 0.024 14.7 0.1 0.042 13.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4550) Ly49 PF08391.5 ESA16756.1 - 0.04 14.0 1.5 0.063 13.3 1.0 1.3 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region HIGH_NTase1 PF05636.6 ESA16756.1 - 0.052 12.5 0.2 0.074 12.0 0.1 1.3 1 1 0 1 1 1 0 HIGH Nucleotidyl Transferase 6PGD PF00393.14 ESA16757.1 - 5.5e-133 442.6 0.0 6.7e-133 442.3 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 ESA16757.1 - 6.6e-53 178.8 0.0 9.4e-53 178.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 ESA16757.1 - 0.0082 16.5 0.1 0.017 15.5 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.1 ESA16757.1 - 0.055 13.5 0.0 0.32 11.0 0.0 2.2 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase CGI-121 PF08617.5 ESA16758.1 - 8.7e-40 136.0 3.3 9.9e-40 135.8 2.3 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 HNF-1A_C PF04813.7 ESA16758.1 - 0.35 11.1 5.0 1.1 9.6 0.0 2.6 2 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus Myb_DNA-binding PF00249.26 ESA16759.1 - 0.00023 21.1 0.0 0.00055 19.9 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF2413 PF10310.4 ESA16759.1 - 4.3 6.0 27.3 6.6 5.4 18.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2413) DUF2182 PF09948.4 ESA16760.1 - 0.11 12.3 0.2 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) DUF1113 PF06541.6 ESA16761.1 - 0.052 13.3 1.5 0.08 12.7 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1113) Pkinase PF00069.20 ESA16763.1 - 9.7e-46 156.0 0.0 1.2e-45 155.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16763.1 - 1.5e-45 155.2 0.0 1.8e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA16763.1 - 7.2e-07 28.4 0.0 6e-06 25.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA16763.1 - 0.00018 21.3 0.0 0.0098 15.6 0.1 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA16763.1 - 0.0017 17.6 0.1 0.0028 16.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA16763.1 - 0.0042 16.4 0.2 0.014 14.7 0.1 1.9 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.9 ESA16763.1 - 0.016 14.2 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IQ PF00612.22 ESA16765.1 - 0.045 13.4 0.9 0.13 11.9 0.6 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Pkinase_Tyr PF07714.12 ESA16766.1 - 1.2e-22 80.2 0.1 3.3e-22 78.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16766.1 - 4.8e-18 65.2 0.7 1.1e-17 64.0 0.5 1.7 1 0 0 1 1 1 1 Protein kinase domain HypA PF01155.14 ESA16766.1 - 0.0093 15.6 9.4 1.5 8.5 0.2 4.2 4 0 0 4 4 4 2 Hydrogenase expression/synthesis hypA family CPSase_sm_chain PF00988.17 ESA16766.1 - 0.063 12.7 0.0 5 6.6 0.0 3.4 4 0 0 4 4 4 0 Carbamoyl-phosphate synthase small chain, CPSase domain APH PF01636.18 ESA16766.1 - 0.073 12.7 0.1 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family zf-C2H2_jaz PF12171.3 ESA16766.1 - 0.31 11.2 8.8 2.7 8.2 1.2 3.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DZR PF12773.2 ESA16766.1 - 2.4 8.0 22.1 2.4 8.0 1.4 4.4 4 0 0 4 4 4 0 Double zinc ribbon BTB PF00651.26 ESA16767.1 - 2.5e-16 59.6 0.0 4.9e-16 58.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16767.1 - 5.1e-15 55.6 1.9 1.7e-14 53.9 0.2 2.4 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA16767.1 - 0.00017 21.3 3.7 0.00031 20.5 0.7 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA16767.1 - 0.028 13.4 0.0 0.23 10.4 0.0 2.2 2 0 0 2 2 2 0 Satellite tobacco necrosis virus coat protein Myosin_N PF02736.14 ESA16768.1 - 0.09 12.4 2.5 0.13 11.9 1.7 1.3 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain DUF4599 PF15371.1 ESA16768.1 - 4.5 7.4 5.0 25 5.0 3.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4599) RRM_1 PF00076.17 ESA16770.1 - 6.2e-05 22.5 0.0 0.00078 19.0 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4419 PF14388.1 ESA16773.1 - 1.1e-38 133.1 0.5 1.8e-38 132.4 0.3 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4419) DUF4419 PF14388.1 ESA16774.1 - 3.7e-68 229.9 0.1 4.1e-68 229.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) DUF4108 PF13390.1 ESA16775.1 - 0.061 13.0 0.9 0.079 12.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4108) Cript PF10235.4 ESA16775.1 - 0.37 11.1 4.4 0.66 10.3 3.0 1.4 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT HTH_Tnp_Tc3_2 PF01498.13 ESA16778.1 - 1.2e-06 28.4 0.1 2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.1 ESA16778.1 - 1.8e-05 25.4 0.1 4.8e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 ESA16778.1 - 0.0001 21.9 0.8 0.0014 18.2 0.2 2.0 1 1 1 2 2 2 1 Transposase HTH_23 PF13384.1 ESA16778.1 - 0.0011 18.5 0.1 0.023 14.3 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_7 PF02796.10 ESA16778.1 - 0.048 13.5 0.2 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase SecD-TM1 PF13721.1 ESA16778.1 - 0.048 13.9 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 SecD export protein N-terminal TM region HTH_Tnp_1 PF01527.15 ESA16778.1 - 0.051 13.5 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Transposase HTH_29 PF13551.1 ESA16778.1 - 0.074 13.2 0.0 0.2 11.7 0.0 1.6 1 1 1 2 2 2 0 Winged helix-turn helix Transposase_mut PF00872.13 ESA16779.1 - 0.001 17.7 4.2 0.0081 14.7 1.2 2.0 2 0 0 2 2 2 2 Transposase, Mutator family DUF4508 PF14969.1 ESA16779.1 - 0.057 13.4 0.1 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF4181 PF13789.1 ESA16779.1 - 0.2 11.6 1.1 0.39 10.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) BTB PF00651.26 ESA16780.1 - 2.6e-13 49.9 0.1 6.1e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16780.1 - 3e-09 36.9 1.9 1.5e-08 34.7 1.3 2.2 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA16780.1 - 0.00065 19.5 2.1 0.0039 17.0 0.5 2.8 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA16780.1 - 0.039 13.1 0.7 0.057 12.5 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Dehyd-heme_bind PF09098.5 ESA16780.1 - 0.049 13.0 0.0 0.81 9.1 0.0 2.5 3 0 0 3 3 3 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding HTH_Tnp_Tc3_2 PF01498.13 ESA16781.1 - 1.2e-05 25.2 0.2 1.5e-05 24.9 0.2 1.1 1 0 0 1 1 1 1 Transposase HTH_DeoR PF08220.7 ESA16781.1 - 0.011 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_11 PF08279.7 ESA16781.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_12 PF08461.5 ESA16781.1 - 0.034 13.8 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain Sel1 PF08238.7 ESA16782.1 - 2e-10 40.9 1.1 3.6e-10 40.1 0.3 1.7 2 0 0 2 2 2 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA16782.1 - 0.015 15.0 0.1 0.019 14.7 0.1 1.2 1 0 0 1 1 1 0 zinc-ribbons DUF2256 PF10013.4 ESA16782.1 - 0.071 12.8 1.1 0.16 11.7 0.3 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) NMD3 PF04981.8 ESA16782.1 - 0.1 11.6 0.9 0.12 11.4 0.6 1.2 1 1 0 1 1 1 0 NMD3 family Haem_bd PF14376.1 ESA16782.1 - 0.12 12.0 1.5 0.14 11.8 1.0 1.2 1 0 0 1 1 1 0 Haem-binding domain Pkinase PF00069.20 ESA16785.1 - 2.3e-75 253.0 0.1 3.5e-75 252.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16785.1 - 7.5e-35 120.2 0.0 1.1e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA16785.1 - 1.3e-08 34.1 0.0 3.3e-07 29.5 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESA16785.1 - 0.00051 19.1 0.0 0.00082 18.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA16785.1 - 0.00083 18.7 0.0 0.0019 17.5 0.0 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA16785.1 - 0.0086 15.8 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family TP_methylase PF00590.15 ESA16786.1 - 1.7e-44 152.0 0.0 2.4e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 ESA16786.1 - 5.8e-25 87.5 0.0 2e-24 85.7 0.0 2.0 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 ESA16786.1 - 6e-21 73.5 0.0 1.1e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 ESA16786.1 - 3.6e-12 45.0 0.0 6.9e-12 44.1 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Hydrolase_6 PF13344.1 ESA16786.1 - 0.14 12.0 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase SUI1 PF01253.17 ESA16788.1 - 0.024 14.4 0.2 0.03 14.1 0.1 1.2 1 0 0 1 1 1 0 Translation initiation factor SUI1 DDE_5 PF13546.1 ESA16788.1 - 0.031 13.1 0.6 0.035 12.9 0.4 1.0 1 0 0 1 1 1 0 DDE superfamily endonuclease ICAP-1_inte_bdg PF10480.4 ESA16788.1 - 3 7.5 6.9 3.4 7.4 4.8 1.1 1 0 0 1 1 1 0 Beta-1 integrin binding protein RRM_6 PF14259.1 ESA16789.1 - 0.0044 16.9 0.0 0.22 11.5 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF1255 PF06865.6 ESA16789.1 - 0.02 15.1 0.9 0.051 13.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1255) VARLMGL PF14383.1 ESA16789.1 - 0.054 12.6 0.2 0.13 11.4 0.1 1.7 1 0 0 1 1 1 0 DUF761-associated sequence motif PIP49_N PF14875.1 ESA16789.1 - 0.12 12.0 5.0 0.89 9.1 0.5 2.5 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 DUF2525 PF10733.4 ESA16789.1 - 0.15 11.8 0.8 4.1 7.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2525) FHIPEP PF00771.15 ESA16789.1 - 4.5 5.4 7.8 0.46 8.7 2.4 1.5 2 0 0 2 2 2 0 FHIPEP family AIG1 PF04548.11 ESA16791.1 - 5.4e-05 22.4 1.9 5.4e-05 22.4 1.3 2.6 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ESA16791.1 - 0.031 14.2 2.0 0.059 13.3 0.1 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA16791.1 - 0.35 11.6 0.1 0.35 11.6 0.0 2.7 2 2 0 2 2 2 0 AAA domain Pkinase_Tyr PF07714.12 ESA16792.1 - 2.9e-32 111.7 0.0 4.8e-32 111.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16792.1 - 3.2e-28 98.6 0.2 7.9e-28 97.3 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain AIG1 PF04548.11 ESA16792.1 - 1.7e-16 59.9 6.3 7.6e-16 57.8 0.6 3.2 3 0 0 3 3 3 1 AIG1 family MMR_HSR1 PF01926.18 ESA16792.1 - 9.4e-08 32.0 1.1 3.4e-07 30.2 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase LRR_4 PF12799.2 ESA16792.1 - 0.00064 19.2 65.0 0.22 11.2 1.5 8.3 2 1 6 8 8 7 3 Leucine Rich repeats (2 copies) DUF258 PF03193.11 ESA16792.1 - 0.0015 17.7 0.0 0.0054 15.9 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA16792.1 - 0.002 18.4 0.1 0.0058 16.9 0.1 1.7 1 0 0 1 1 1 1 ABC transporter RIO1 PF01163.17 ESA16792.1 - 0.011 15.1 0.1 0.026 13.8 0.1 1.6 1 0 0 1 1 1 0 RIO1 family AAA_18 PF13238.1 ESA16792.1 - 0.013 15.8 1.9 0.066 13.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.22 ESA16792.1 - 0.018 14.5 0.1 0.05 13.0 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Kdo PF06293.9 ESA16792.1 - 0.018 14.1 0.1 0.04 12.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_7 PF13504.1 ESA16792.1 - 0.02 15.0 38.8 7.4 7.2 0.2 11.2 6 3 2 8 8 8 0 Leucine rich repeat FeoB_N PF02421.13 ESA16792.1 - 0.033 13.4 1.7 0.061 12.5 0.1 2.3 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_29 PF13555.1 ESA16792.1 - 0.045 13.2 0.1 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 ESA16792.1 - 0.049 13.0 0.3 0.32 10.3 0.0 2.5 3 0 0 3 3 3 0 AAA-like domain PduV-EutP PF10662.4 ESA16792.1 - 0.062 12.7 0.0 0.23 10.9 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SE PF00437.15 ESA16792.1 - 0.063 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 ESA16792.1 - 0.12 11.7 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_17 PF13207.1 ESA16792.1 - 0.14 12.9 5.7 2 9.2 3.9 2.9 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.12 ESA16792.1 - 0.16 11.7 2.8 0.2 11.4 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function DUF87 AIG1 PF04548.11 ESA16793.1 - 2.3e-11 43.2 3.2 3.5e-11 42.6 2.2 1.3 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA16793.1 - 2.4e-10 40.3 1.3 4.2e-10 39.6 0.2 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA16793.1 - 0.00032 19.9 0.7 0.00074 18.8 0.1 1.9 1 1 1 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 ESA16793.1 - 0.0066 15.6 1.1 0.07 12.3 0.7 2.4 1 1 0 1 1 1 1 Protein of unknown function, DUF258 MobB PF03205.9 ESA16793.1 - 0.015 14.9 0.1 0.052 13.2 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 ESA16793.1 - 0.046 14.2 0.3 0.12 12.9 0.1 1.9 1 1 1 2 2 2 0 Miro-like protein Dynamin_N PF00350.18 ESA16793.1 - 0.051 13.4 2.4 0.38 10.5 1.6 2.4 1 1 0 1 1 1 0 Dynamin family EFG_IV PF03764.13 ESA16793.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Elongation factor G, domain IV ABC_tran PF00005.22 ESA16793.1 - 0.16 12.2 0.6 0.26 11.5 0.2 1.6 1 1 0 1 1 1 0 ABC transporter LRR_4 PF12799.2 ESA16793.1 - 0.57 9.8 9.6 1.4 8.6 5.0 2.7 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) AIG1 PF04548.11 ESA16794.1 - 0.0028 16.8 0.3 0.0033 16.5 0.2 1.2 1 0 0 1 1 1 1 AIG1 family BTB PF00651.26 ESA16795.1 - 6.7e-18 64.7 0.1 9.1e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Nefa_Nip30_N PF10187.4 ESA16797.1 - 0.036 14.2 1.6 0.12 12.5 0.5 2.3 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF3095 PF11294.3 ESA16797.1 - 0.071 12.1 0.1 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) MMR_HSR1 PF01926.18 ESA16798.1 - 9.1e-08 32.0 0.0 9.4e-08 32.0 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_17 PF13207.1 ESA16798.1 - 9.3e-05 23.2 0.0 9.5e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain Septin PF00735.13 ESA16798.1 - 0.0001 21.4 0.0 0.0001 21.4 0.0 1.0 1 0 0 1 1 1 1 Septin AIG1 PF04548.11 ESA16798.1 - 0.00011 21.3 0.0 0.00012 21.2 0.0 1.0 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.22 ESA16798.1 - 0.00029 20.3 0.0 0.0003 20.2 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MobB PF03205.9 ESA16798.1 - 0.0011 18.6 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 ESA16798.1 - 0.0018 18.6 0.2 0.0021 18.4 0.1 1.0 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 ESA16798.1 - 0.0021 17.2 0.0 0.0021 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Ras PF00071.17 ESA16798.1 - 0.003 16.9 0.0 0.0031 16.9 0.0 1.1 1 0 0 1 1 1 1 Ras family ABC_tran PF00005.22 ESA16798.1 - 0.0032 17.7 0.0 0.0032 17.7 0.0 1.1 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.13 ESA16798.1 - 0.0059 15.8 0.0 0.0059 15.8 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.1 ESA16798.1 - 0.0063 16.0 0.0 0.0067 15.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain PduV-EutP PF10662.4 ESA16798.1 - 0.0077 15.7 0.0 0.0085 15.5 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.1 ESA16798.1 - 0.0085 16.4 0.0 0.0097 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESA16798.1 - 0.0087 16.2 0.0 0.0096 16.0 0.0 1.1 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.1 ESA16798.1 - 0.011 15.6 0.1 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESA16798.1 - 0.046 14.2 0.0 0.052 14.0 0.0 1.1 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 ESA16798.1 - 0.051 13.4 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESA16798.1 - 0.053 12.9 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESA16798.1 - 0.1 12.7 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA16798.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 ESA16798.1 - 0.16 11.9 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AIG1 PF04548.11 ESA16799.1 - 1.2e-16 60.4 1.4 1.8e-13 50.1 0.0 3.3 2 1 1 3 3 3 2 AIG1 family MMR_HSR1 PF01926.18 ESA16799.1 - 1.6e-09 37.6 0.0 5.2e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase LRR_4 PF12799.2 ESA16799.1 - 4.5e-05 22.9 46.1 1.3 8.7 2.9 8.0 1 1 4 5 5 4 2 Leucine Rich repeats (2 copies) ABC_tran PF00005.22 ESA16799.1 - 4.9e-05 23.6 0.0 9.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.13 ESA16799.1 - 0.00031 20.0 0.1 0.0012 18.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 ESA16799.1 - 0.00038 19.6 0.0 0.00092 18.4 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Septin PF00735.13 ESA16799.1 - 0.00054 19.0 0.1 0.001 18.1 0.0 1.6 1 0 0 1 1 1 1 Septin T2SE PF00437.15 ESA16799.1 - 0.00081 18.3 0.0 0.0014 17.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.12 ESA16799.1 - 0.0023 17.7 0.1 0.0054 16.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_29 PF13555.1 ESA16799.1 - 0.0042 16.5 0.1 0.01 15.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 ESA16799.1 - 0.0054 17.0 0.3 0.022 15.0 0.0 2.1 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.13 ESA16799.1 - 0.0074 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_17 PF13207.1 ESA16799.1 - 0.0094 16.7 0.0 0.022 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 ESA16799.1 - 0.017 14.5 0.0 0.039 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.1 ESA16799.1 - 0.018 15.1 0.0 0.08 13.0 0.0 2.2 2 0 0 2 2 1 0 AAA domain DUF1257 PF06868.6 ESA16799.1 - 0.047 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) LRR_7 PF13504.1 ESA16799.1 - 0.051 13.7 35.6 6.8 7.3 0.1 11.2 5 2 4 9 9 9 0 Leucine rich repeat GTP_EFTU PF00009.22 ESA16799.1 - 0.076 12.4 0.1 0.44 9.9 0.0 2.3 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 ESA16799.1 - 0.095 12.1 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SLEI_Leptospira PF07620.6 ESA16799.1 - 0.25 11.2 10.1 2.8 7.9 0.3 4.9 4 0 0 4 4 4 0 SLEI LRR_8 PF13855.1 ESA16799.1 - 0.36 10.6 39.5 1 9.1 1.3 6.7 1 1 6 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 ESA16799.1 - 2.7 8.3 41.3 18 5.8 0.1 10.3 5 3 2 8 8 8 0 Leucine Rich Repeat ChW PF07538.6 ESA16800.1 - 0.1 12.1 0.6 0.18 11.3 0.4 1.3 1 0 0 1 1 1 0 Clostridial hydrophobic W MFS_2 PF13347.1 ESA16800.1 - 0.38 9.1 4.4 0.41 8.9 3.0 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein Ins145_P3_rec PF08709.6 ESA16801.1 - 0.024 13.6 0.0 0.047 12.7 0.0 1.5 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor GH114_assoc PF14741.1 ESA16801.1 - 0.05 13.3 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain MIR PF02815.14 ESA16801.1 - 0.076 12.5 0.1 0.21 11.0 0.0 1.9 1 1 0 1 1 1 0 MIR domain UBN2 PF14223.1 ESA16801.1 - 0.46 10.2 2.5 1.2 8.9 0.4 2.2 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type Ank_2 PF12796.2 ESA16802.1 - 1.3e-28 99.1 15.3 1.9e-08 34.5 0.6 9.2 3 3 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 ESA16802.1 - 9.4e-21 72.5 14.7 0.00015 21.4 0.1 10.1 10 0 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.1 ESA16802.1 - 2.4e-20 72.0 1.9 0.00022 21.3 0.5 8.8 9 1 1 10 10 10 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA16802.1 - 7e-17 59.8 16.1 0.031 14.5 0.1 11.2 11 1 1 12 12 12 6 Ankyrin repeat Ank_4 PF13637.1 ESA16802.1 - 4.7e-12 46.0 6.7 0.00093 19.6 0.6 8.2 7 1 3 10 10 10 5 Ankyrin repeats (many copies) Phage_int_SAM_4 PF13495.1 ESA16802.1 - 0.03 14.6 6.4 0.047 14.0 0.4 3.9 3 1 1 4 4 4 0 Phage integrase, N-terminal SAM-like domain Pkinase_Tyr PF07714.12 ESA16803.1 - 2.7e-43 147.9 0.0 4.1e-43 147.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16803.1 - 2.4e-41 141.6 0.2 3.6e-41 141.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA16803.1 - 0.00024 20.5 1.1 0.0011 18.4 0.7 2.1 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA16803.1 - 0.002 17.9 0.1 0.0074 16.0 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family TBPIP PF07106.8 ESA16804.1 - 0.0051 16.3 13.9 0.0051 16.3 9.6 2.4 1 1 1 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Herpes_BLRF2 PF05812.7 ESA16804.1 - 0.011 15.4 1.3 0.011 15.4 0.9 4.3 1 1 3 4 4 4 0 Herpesvirus BLRF2 protein DUF3410 PF11890.3 ESA16804.1 - 0.027 14.0 2.7 0.029 14.0 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3410) DUF4164 PF13747.1 ESA16804.1 - 0.087 12.9 7.5 1.2 9.2 0.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) bZIP_1 PF00170.16 ESA16804.1 - 0.17 11.8 25.5 0.43 10.5 0.5 4.7 2 2 3 5 5 5 0 bZIP transcription factor DUF4140 PF13600.1 ESA16804.1 - 0.24 11.8 3.8 11 6.4 0.1 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Rab5-bind PF09311.6 ESA16804.1 - 1.1 9.0 11.9 0.26 11.1 0.4 3.2 2 2 2 4 4 4 0 Rabaptin-like protein DUF4473 PF14747.1 ESA16804.1 - 1.8 8.8 7.9 0.44 10.7 0.2 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4473) CENP-F_leu_zip PF10473.4 ESA16804.1 - 1.8 8.4 17.0 0.45 10.3 6.1 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.6 ESA16804.1 - 2.6 7.9 7.8 0.6 9.9 2.2 2.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) APG6 PF04111.7 ESA16804.1 - 2.6 7.0 20.2 0.28 10.1 7.2 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF972 PF06156.8 ESA16804.1 - 2.8 8.3 21.0 0.3 11.4 3.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Seryl_tRNA_N PF02403.17 ESA16804.1 - 3.4 7.7 19.0 4.1 7.4 1.6 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BTB PF00651.26 ESA16805.1 - 1.9e-17 63.2 0.2 5.2e-17 61.8 0.1 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16805.1 - 2.7e-10 40.3 0.5 5.8e-10 39.3 0.4 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16805.1 - 4.3e-05 23.2 2.8 0.0002 21.1 0.3 3.0 1 1 2 3 3 3 1 BTB And C-terminal Kelch DDE_1 PF03184.14 ESA16807.1 - 1.7e-42 144.9 0.3 4.1e-21 75.1 0.1 2.1 2 0 0 2 2 2 2 DDE superfamily endonuclease Nop14 PF04147.7 ESA16807.1 - 1.9e-05 22.8 4.4 2.1e-05 22.6 3.1 1.2 1 0 0 1 1 1 1 Nop14-like family DDE_3 PF13358.1 ESA16807.1 - 2.5e-05 24.0 0.0 4.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease CDC45 PF02724.9 ESA16807.1 - 0.0081 14.2 3.9 0.01 13.8 2.7 1.2 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.5 ESA16807.1 - 0.2 10.7 7.7 0.28 10.2 5.4 1.2 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.6 ESA16807.1 - 0.3 9.1 4.1 0.38 8.7 2.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.8 ESA16807.1 - 1.3 8.5 10.1 2 7.9 7.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Pox_RNA_Pol_19 PF05320.7 ESA16807.1 - 9 6.0 13.2 1.9 8.2 6.3 2.0 3 0 0 3 3 3 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF1914 PF08932.5 ESA16808.1 - 0.024 14.6 0.3 0.037 14.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1914) Leuk-A4-hydro_C PF09127.6 ESA16808.1 - 0.17 11.4 2.0 0.27 10.8 0.3 1.8 2 0 0 2 2 2 0 Leukotriene A4 hydrolase, C-terminal Phage_min_cap2 PF06152.6 ESA16810.1 - 0.0068 15.4 0.0 0.017 14.1 0.0 1.6 1 1 1 2 2 2 1 Phage minor capsid protein 2 RdRP_4 PF02123.11 ESA16810.1 - 0.056 12.1 0.3 0.069 11.8 0.2 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase Gemini_AL3 PF01407.12 ESA16810.1 - 0.24 10.8 3.2 0.17 11.3 1.2 1.5 2 0 0 2 2 2 0 Geminivirus AL3 protein Replicase PF03090.12 ESA16814.1 - 0.045 13.6 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 Replicase family CBM_20 PF00686.14 ESA16814.1 - 0.095 12.3 0.2 0.25 10.9 0.2 1.7 1 1 1 2 2 2 0 Starch binding domain Pkinase PF00069.20 ESA16817.1 - 1.1e-34 119.8 1.0 1.3e-34 119.5 0.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16817.1 - 1.4e-34 119.3 0.1 1.9e-34 118.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA16817.1 - 0.0079 15.1 0.0 0.018 13.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA16817.1 - 0.019 14.0 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA16817.1 - 0.061 13.0 0.2 3.4 7.3 0.1 2.1 1 1 0 2 2 2 0 Phosphotransferase enzyme family TLD PF07534.11 ESA16818.1 - 4.3e-09 36.4 8.1 9.2e-09 35.4 2.2 2.5 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA16818.1 - 5.3e-09 36.0 0.0 1.1e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA16818.1 - 0.24 11.2 1.8 0.96 9.3 0.3 2.5 3 0 0 3 3 3 0 BTB And C-terminal Kelch Mito_carr PF00153.22 ESA16820.1 - 2.4e-13 49.5 0.1 2.5e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial carrier protein Lipid_bd PF12888.2 ESA16820.1 - 0.12 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipid-binding putative hydrolase PDZ_2 PF13180.1 ESA16821.1 - 5.7e-10 38.9 0.1 5.1e-06 26.2 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_1 PF12812.2 ESA16821.1 - 1.4e-07 31.2 0.1 4.5e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 PDZ-like domain Tricorn_PDZ PF14685.1 ESA16821.1 - 0.0027 17.4 0.0 2.2 8.1 0.0 2.6 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ PF00595.19 ESA16821.1 - 0.036 14.2 0.7 0.18 12.0 0.0 2.5 3 0 0 3 3 3 0 PDZ domain (Also known as DHR or GLGF) CN_hydrolase PF00795.17 ESA16824.1 - 2.9e-29 101.7 0.0 4.3e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DivIC PF04977.10 ESA16830.1 - 0.00015 21.1 17.5 0.32 10.5 0.9 3.6 2 1 1 3 3 3 3 Septum formation initiator ATG16 PF08614.6 ESA16830.1 - 0.011 15.5 17.2 0.013 15.3 5.1 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3573 PF12097.3 ESA16830.1 - 0.012 14.2 5.7 0.027 13.0 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) DUF4200 PF13863.1 ESA16830.1 - 0.029 14.2 19.3 0.24 11.3 11.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Microtub_assoc PF07989.6 ESA16830.1 - 0.034 13.9 15.7 0.088 12.6 5.1 3.6 2 1 1 3 3 3 0 Microtubule associated Rootletin PF15035.1 ESA16830.1 - 0.13 12.1 20.5 0.43 10.5 13.9 1.8 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion MerR-DNA-bind PF09278.6 ESA16830.1 - 0.19 12.1 6.1 0.15 12.4 1.7 2.5 2 0 0 2 2 2 0 MerR, DNA binding Bap31 PF05529.7 ESA16830.1 - 0.2 11.1 12.8 0.24 10.8 1.1 2.2 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like TPR_MLP1_2 PF07926.7 ESA16830.1 - 0.24 11.1 13.7 1.2 8.9 0.2 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1192 PF06698.6 ESA16830.1 - 0.44 10.4 13.5 6.6 6.6 0.4 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) DUF724 PF05266.9 ESA16830.1 - 0.99 8.9 18.8 0.32 10.6 4.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Erp_C PF06780.6 ESA16830.1 - 1.1 9.1 16.9 0.1 12.4 5.7 2.3 1 1 1 2 2 2 0 Erp protein C-terminus CorA PF01544.13 ESA16830.1 - 1.1 8.2 9.2 1.6 7.6 5.8 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein bZIP_1 PF00170.16 ESA16830.1 - 1.1 9.2 18.2 3 7.8 1.1 4.1 2 1 3 5 5 4 0 bZIP transcription factor TMF_TATA_bd PF12325.3 ESA16830.1 - 1.5 8.6 20.3 0.3 10.8 7.7 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FlxA PF14282.1 ESA16830.1 - 1.7 8.6 9.8 0.55 10.2 0.4 2.5 1 1 0 2 2 2 0 FlxA-like protein Ax_dynein_light PF10211.4 ESA16830.1 - 1.9 8.3 20.0 3.5 7.4 4.4 2.6 1 1 2 3 3 3 0 Axonemal dynein light chain CENP-F_leu_zip PF10473.4 ESA16830.1 - 2.4 8.0 22.4 3.4 7.5 9.7 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_L29 PF00831.18 ESA16830.1 - 2.5 7.8 15.9 8.4 6.1 0.4 4.6 3 2 1 4 4 4 0 Ribosomal L29 protein AKNA PF12443.3 ESA16830.1 - 3 7.9 9.4 6.3 6.8 3.4 3.2 1 1 3 4 4 4 0 AT-hook-containing transcription factor IncA PF04156.9 ESA16830.1 - 3.1 7.3 23.2 8.3 5.9 1.9 2.3 1 1 0 2 2 2 0 IncA protein TMF_DNA_bd PF12329.3 ESA16830.1 - 3.3 7.5 18.5 19 5.1 4.2 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DMPK_coil PF08826.5 ESA16830.1 - 3.9 7.4 16.8 7.8 6.4 1.3 4.2 1 1 3 4 4 4 0 DMPK coiled coil domain like Striatin PF08232.7 ESA16830.1 - 3.9 7.7 17.1 3.3 8.0 8.0 2.6 1 1 1 2 2 2 0 Striatin family MutS_IV PF05190.13 ESA16830.1 - 4.3 7.5 10.5 8.6 6.6 0.8 2.7 2 1 0 2 2 2 0 MutS family domain IV Tnp_P_element PF12017.3 ESA16830.1 - 4.3 6.5 9.4 5.2 6.2 1.6 2.2 1 1 0 2 2 2 0 Transposase protein DUF972 PF06156.8 ESA16830.1 - 5.7 7.3 16.4 6 7.2 2.6 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF904 PF06005.7 ESA16830.1 - 6.9 7.0 24.3 1.1 9.6 1.1 3.7 3 1 0 3 3 2 0 Protein of unknown function (DUF904) Shugoshin_N PF07558.6 ESA16830.1 - 7 6.4 8.3 24 4.7 2.4 3.4 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Mnd1 PF03962.10 ESA16830.1 - 8 6.0 17.7 6.4 6.3 5.7 2.2 1 1 1 2 2 2 0 Mnd1 family Dimer_Tnp_hAT PF05699.9 ESA16835.1 - 1.4e-18 66.2 0.0 1.6e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region CX PF01705.14 ESA16836.1 - 0.005 16.7 0.2 0.0067 16.3 0.1 1.2 1 0 0 1 1 1 1 CX module RNase_H PF00075.19 ESA16838.1 - 1.3e-05 25.5 0.1 2.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 RNase H DnaB_2 PF07261.6 ESA16840.1 - 0.013 15.0 0.1 0.037 13.6 0.0 1.8 1 1 0 1 1 1 0 Replication initiation and membrane attachment Pkinase_Tyr PF07714.12 ESA16840.1 - 0.054 12.5 0.0 0.083 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase RNA_pol_Rbc25 PF08292.7 ESA16840.1 - 0.26 11.4 2.7 0.54 10.4 1.9 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Ctr PF04145.10 ESA16842.1 - 1.1e-06 28.7 8.5 0.00023 21.2 2.6 2.1 1 1 1 2 2 2 2 Ctr copper transporter family DUF3754 PF12576.3 ESA16842.1 - 0.055 13.1 0.3 0.055 13.1 0.2 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3754) DUF3671 PF12420.3 ESA16842.1 - 1.6 8.7 9.2 5.8 6.9 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function AA_permease_2 PF13520.1 ESA16843.1 - 5.2e-74 249.2 43.5 6.3e-74 249.0 30.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 ESA16843.1 - 2.6e-36 124.9 37.5 3.7e-36 124.5 26.0 1.1 1 0 0 1 1 1 1 Amino acid permease Kei1 PF08552.6 ESA16844.1 - 2.2e-10 40.5 5.0 1.7e-08 34.3 3.5 2.0 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Gemini_mov PF01708.11 ESA16844.1 - 0.031 13.8 0.3 0.046 13.2 0.1 1.4 1 1 0 1 1 1 0 Geminivirus putative movement protein MFS_1 PF07690.11 ESA16844.1 - 0.087 11.5 3.6 0.098 11.3 2.5 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily Vel1p PF10339.4 ESA16846.1 - 0.014 14.5 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Yeast-specific zinc responsive RVT_1 PF00078.22 ESA16850.1 - 2.4e-13 49.9 0.0 3e-09 36.5 0.0 2.7 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Acyl_CoA_thio PF02551.10 ESA16850.1 - 0.076 12.6 2.4 1 8.9 0.0 3.0 3 0 0 3 3 3 0 Acyl-CoA thioesterase Abhydrolase_3 PF07859.8 ESA16852.1 - 2.9e-13 49.8 0.0 4.1e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold BSD PF03909.12 ESA16852.1 - 0.19 11.4 0.6 0.83 9.4 0.2 2.0 2 0 0 2 2 2 0 BSD domain FAR1 PF03101.10 ESA16856.1 - 9.2e-07 29.2 6.0 5.9e-06 26.7 4.1 2.2 1 1 0 1 1 1 1 FAR1 DNA-binding domain Phage_BR0599 PF09356.5 ESA16856.1 - 0.12 12.5 0.2 0.31 11.2 0.0 1.8 2 0 0 2 2 2 0 Phage conserved hypothetical protein BR0599 Scm3 PF10384.4 ESA16856.1 - 0.43 10.1 4.5 40 3.8 0.0 3.7 3 0 0 3 3 3 0 Centromere protein Scm3 ubiquitin PF00240.18 ESA16858.1 - 2.6e-13 49.1 0.2 5.4e-13 48.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA16858.1 - 0.00014 21.4 0.1 0.00032 20.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 ESA16858.1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 ESA16858.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain zf-tcix PF14952.1 ESA16858.1 - 8.1 5.8 22.5 4 6.8 4.5 3.6 4 0 0 4 4 4 0 Putative treble-clef, zinc-finger, Zn-binding DUF2115 PF09888.4 ESA16859.1 - 5.2 7.1 10.4 1.5 8.9 2.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Spc97_Spc98 PF04130.8 ESA16861.1 - 0.011 14.0 2.3 0.012 14.0 1.6 1.0 1 0 0 1 1 1 0 Spc97 / Spc98 family Pkinase_Tyr PF07714.12 ESA16864.1 - 8e-29 100.4 0.4 4.6e-21 75.0 0.0 6.2 6 1 1 7 7 7 3 Protein tyrosine kinase Pkinase PF00069.20 ESA16864.1 - 1.4e-23 83.4 0.1 1.4e-23 83.4 0.1 4.1 4 0 0 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ESA16864.1 - 0.0063 16.1 0.9 0.74 9.3 0.0 4.1 5 0 0 5 5 5 1 BCS1 N terminal NOB1_Zn_bind PF08772.6 ESA16864.1 - 0.017 14.8 39.4 1.1 9.1 0.5 7.0 7 0 0 7 7 7 0 Nin one binding (NOB1) Zn-ribbon like DUF3299 PF11736.3 ESA16864.1 - 0.022 14.6 0.2 50 3.7 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3299) THF_DHG_CYH PF00763.18 ESA16864.1 - 0.041 13.9 3.8 1.6 8.8 0.0 3.5 4 0 0 4 4 4 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain SHS2_FTSA PF02491.15 ESA16864.1 - 0.15 11.9 1.7 5.4 6.9 0.0 3.9 3 0 0 3 3 3 0 SHS2 domain inserted in FTSA zf-DBF PF07535.7 ESA16864.1 - 1 9.0 39.8 0.026 14.1 0.6 6.8 6 1 0 6 6 6 0 DBF zinc finger HCBP_related PF06594.6 ESA16865.1 - 0.082 12.5 0.1 7.7 6.2 0.0 2.7 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain Synaptobrevin PF00957.16 ESA16867.1 - 2.3e-06 27.1 1.9 2.3e-06 27.1 1.3 2.5 2 0 0 2 2 2 1 Synaptobrevin MutL_C PF08676.6 ESA16868.1 - 6.7e-07 28.9 0.4 0.00016 21.3 0.1 3.5 2 1 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 ESA16868.1 - 6.3e-05 22.4 0.0 0.00022 20.6 0.0 1.9 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain NADH-u_ox-rdase PF10785.4 ESA16871.1 - 6.8e-31 106.3 0.1 9.1e-31 105.9 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.2 ESA16871.1 - 8.7e-16 57.4 0.1 1.3e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Med7 PF05983.6 ESA16872.1 - 3.7e-47 160.1 2.2 4.4e-47 159.8 1.5 1.0 1 0 0 1 1 1 1 MED7 protein DUF2383 PF09537.5 ESA16872.1 - 0.01 16.0 0.3 0.021 15.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) Mis12 PF05859.7 ESA16872.1 - 0.031 14.0 1.1 0.05 13.4 0.8 1.3 1 0 0 1 1 1 0 Mis12 protein Cir_Bir_Yir PF06022.6 ESA16872.1 - 0.05 12.8 0.3 0.067 12.4 0.2 1.1 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir GAS PF13851.1 ESA16872.1 - 0.11 11.6 9.1 0.27 10.3 0.1 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding cwf21 PF08312.7 ESA16872.1 - 0.14 12.0 1.8 0.43 10.4 0.7 2.1 2 0 0 2 2 2 0 cwf21 domain rRNA_proc-arch PF13234.1 ESA16873.1 - 2.5e-54 184.2 1.7 3.9e-54 183.6 1.2 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 ESA16873.1 - 2.9e-52 176.5 0.0 6.5e-52 175.3 0.0 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 ESA16873.1 - 8.1e-24 84.0 0.0 1e-22 80.4 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA16873.1 - 8.6e-09 35.1 0.0 2.6e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA16873.1 - 0.0039 17.0 0.3 0.025 14.4 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SE PF00437.15 ESA16873.1 - 0.018 13.9 0.0 0.032 13.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.11 ESA16873.1 - 0.05 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein FemAB PF02388.11 ESA16874.1 - 0.00044 19.0 7.6 0.00077 18.2 5.2 1.3 1 0 0 1 1 1 1 FemAB family Tropomyosin_1 PF12718.2 ESA16874.1 - 0.0018 18.1 12.3 0.0045 16.8 8.5 1.8 1 1 0 1 1 1 1 Tropomyosin like APG6 PF04111.7 ESA16874.1 - 0.0022 17.1 10.2 0.0022 17.1 7.1 1.4 2 0 0 2 2 2 1 Autophagy protein Apg6 BRE1 PF08647.6 ESA16874.1 - 0.055 13.4 9.4 0.11 12.4 6.5 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase bZIP_2 PF07716.10 ESA16874.1 - 0.091 12.6 4.6 0.26 11.1 1.2 2.5 2 0 0 2 2 2 0 Basic region leucine zipper PDCD2_C PF04194.8 ESA16874.1 - 0.25 10.9 3.6 0.25 10.9 2.0 1.3 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain DUF2616 PF11077.3 ESA16874.1 - 0.43 10.0 6.1 0.053 13.0 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) Fib_alpha PF08702.5 ESA16874.1 - 1.4 8.9 6.6 1.1 9.3 3.3 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF16 PF01519.11 ESA16874.1 - 1.5 9.0 10.7 0.31 11.2 4.9 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF3340 PF11818.3 ESA16874.1 - 1.7 8.5 10.5 4.2 7.3 7.3 1.6 1 1 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) IncA PF04156.9 ESA16874.1 - 2.4 7.6 7.7 3.4 7.1 5.3 1.3 1 0 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 ESA16874.1 - 6.9 6.5 18.7 19 5.1 10.7 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF972 PF06156.8 ESA16875.1 - 0.063 13.6 1.5 0.072 13.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) GCOM2 PF15328.1 ESA16875.1 - 0.07 12.8 2.7 0.083 12.6 1.9 1.0 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 DUF1911 PF08929.5 ESA16877.1 - 0.051 14.2 0.1 0.086 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) MAP65_ASE1 PF03999.7 ESA16880.1 - 3.9e-27 95.1 26.5 4.9e-27 94.8 14.8 2.2 2 0 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) DUF3921 PF13060.1 ESA16880.1 - 0.061 13.2 1.3 1.7 8.5 0.1 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3921) GreA_GreB_N PF03449.10 ESA16880.1 - 2.8 8.0 10.1 3.4 7.7 0.2 3.7 3 1 0 3 3 3 0 Transcription elongation factor, N-terminal zf-H2C2_2 PF13465.1 ESA16881.1 - 4.2e-10 39.3 25.7 1.6e-06 28.1 0.4 4.8 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA16881.1 - 4.1e-08 33.0 18.6 0.00025 21.1 0.1 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA16881.1 - 5e-08 32.8 33.0 3.5e-06 27.0 0.2 4.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-TRAF PF02176.13 ESA16881.1 - 0.089 13.1 8.2 0.07 13.5 1.7 2.8 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.3 ESA16881.1 - 1.4 9.1 12.7 1 9.6 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Tetraspannin PF00335.15 ESA16883.1 - 0.099 11.9 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Tetraspanin family Abhydrolase_3 PF07859.8 ESA16884.1 - 0.00018 21.1 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hid1 PF12722.2 ESA16885.1 - 1.4e-218 727.8 18.7 2.1e-218 727.3 13.0 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.4 ESA16885.1 - 3.1e-98 329.6 5.5 5.4e-98 328.8 3.8 1.4 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein tRNA-synt_1b PF00579.20 ESA16886.1 - 9.8e-68 228.3 0.0 1.5e-67 227.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.15 ESA16886.1 - 9.7e-24 83.0 0.0 1.7e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain RRM_1 PF00076.17 ESA16888.1 - 0.0031 17.1 0.0 0.0078 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OEP PF02321.13 ESA16888.1 - 0.091 12.3 1.8 0.12 11.9 1.3 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein Polysacc_deac_1 PF01522.16 ESA16889.1 - 2.7e-34 117.4 0.0 4.4e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA16889.1 - 0.00012 21.1 0.5 0.00082 18.3 0.1 2.2 1 1 2 3 3 3 1 Glycosyl hydrolase family 57 SSP160 PF06933.6 ESA16889.1 - 6.6 4.5 19.8 13 3.5 13.7 1.5 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Lipoprotein_3 PF00938.12 ESA16890.1 - 0.15 11.8 0.3 0.3 10.8 0.1 1.6 1 1 1 2 2 2 0 Lipoprotein UDG PF03167.14 ESA16891.1 - 3.3e-09 36.3 0.0 4.3e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Pkinase_Tyr PF07714.12 ESA16892.1 - 8.7e-05 21.7 0.0 9.7e-05 21.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16892.1 - 0.0087 15.2 0.0 0.0088 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16893.1 - 1.8e-09 37.0 0.0 2e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16893.1 - 3.6e-09 36.1 0.0 3.9e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA16893.1 - 0.084 12.5 0.1 0.098 12.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Glycos_transf_3 PF00591.16 ESA16894.1 - 1.5e-58 198.1 1.5 1.5e-58 198.1 1.0 1.4 2 0 0 2 2 2 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 ESA16894.1 - 3.3e-07 29.8 0.0 6.4e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain AIG2 PF06094.7 ESA16895.1 - 0.00013 22.4 0.0 0.00015 22.2 0.0 1.1 1 0 0 1 1 1 1 AIG2-like family AIG2_2 PF13772.1 ESA16895.1 - 0.049 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 AIG2-like family Presenilin PF01080.12 ESA16896.1 - 5.5e-88 295.5 9.1 5.5e-88 295.5 6.3 1.5 2 0 0 2 2 2 1 Presenilin zf-MYND PF01753.13 ESA16896.1 - 9.1e-06 25.4 13.8 1.3e-05 24.9 9.6 1.3 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.11 ESA16896.1 - 0.0041 16.7 10.9 0.0079 15.8 7.6 1.4 1 0 0 1 1 1 1 HIT zinc finger DUF3592 PF12158.3 ESA16896.1 - 0.13 12.0 5.1 0.48 10.1 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3592) Baculo_E56 PF04639.7 ESA16896.1 - 0.28 9.8 1.7 0.58 8.7 1.2 1.5 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope zf-B_box PF00643.19 ESA16896.1 - 0.42 10.5 4.1 0.76 9.7 2.8 1.3 1 0 0 1 1 1 0 B-box zinc finger Sec62 PF03839.11 ESA16896.1 - 1.3 8.3 7.2 2.8 7.2 5.0 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 Toxin_R_bind_C PF07951.7 ESA16897.1 - 0.0094 15.6 5.0 0.013 15.1 3.5 1.2 1 0 0 1 1 1 1 Clostridium neurotoxin, C-terminal receptor binding Flu_NS2 PF00601.14 ESA16897.1 - 0.039 14.1 0.7 0.039 14.1 0.5 2.1 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) Cys_Met_Meta_PP PF01053.15 ESA16898.1 - 2.6e-136 453.9 0.0 2.9e-136 453.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.6 ESA16898.1 - 0.00028 19.3 0.0 0.0023 16.2 0.0 2.0 1 1 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.16 ESA16898.1 - 0.0003 19.8 0.0 0.00058 18.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DHFR_1 PF00186.14 ESA16899.1 - 4.8e-37 127.0 0.1 2.7e-28 98.5 0.0 2.2 2 0 0 2 2 2 2 Dihydrofolate reductase MULE PF10551.4 ESA16901.1 - 0.00045 20.3 0.0 0.0013 18.8 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain Transposase_mut PF00872.13 ESA16901.1 - 0.0098 14.4 0.1 0.013 14.0 0.1 1.2 1 0 0 1 1 1 1 Transposase, Mutator family HMG_box_2 PF09011.5 ESA16902.1 - 0.0074 16.6 0.1 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA16902.1 - 0.018 15.3 0.2 0.031 14.5 0.1 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box Pkinase_Tyr PF07714.12 ESA16903.1 - 1.2e-34 119.5 0.0 1.7e-34 119.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA16903.1 - 2.6e-33 113.6 8.2 5.2e-09 36.4 0.0 5.4 5 0 0 5 5 5 5 Sel1 repeat Pkinase PF00069.20 ESA16903.1 - 4.5e-32 111.2 0.1 8.4e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA16903.1 - 0.00014 21.0 0.1 0.00027 20.0 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA16903.1 - 0.002 17.1 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA16903.1 - 0.0038 16.5 0.4 0.009 15.3 0.3 1.6 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA16903.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2535 PF10751.4 ESA16904.1 - 0.11 12.6 0.1 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2535) Cag12 PF13117.1 ESA16904.1 - 0.12 12.3 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Cag pathogenicity island protein Cag12 Ku_PK_bind PF08785.6 ESA16904.1 - 0.13 12.1 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Ku C terminal domain like DUF70 PF01901.11 ESA16905.1 - 0.0092 15.0 0.1 0.0099 14.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF70 Glucos_trans_II PF14264.1 ESA16905.1 - 0.011 14.7 1.4 0.013 14.5 1.0 1.0 1 0 0 1 1 1 0 Glucosyl transferase GtrII FTR1 PF03239.9 ESA16905.1 - 0.012 14.5 0.1 0.014 14.3 0.1 1.0 1 0 0 1 1 1 0 Iron permease FTR1 family Choline_transpo PF04515.7 ESA16905.1 - 0.016 13.9 0.4 0.018 13.7 0.3 1.0 1 0 0 1 1 1 0 Plasma-membrane choline transporter DUF4131 PF13567.1 ESA16905.1 - 0.051 12.9 0.4 0.057 12.8 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4149 PF13664.1 ESA16905.1 - 0.058 13.4 0.2 0.069 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) Nramp PF01566.13 ESA16905.1 - 0.061 12.1 0.9 0.064 12.0 0.6 1.0 1 0 0 1 1 1 0 Natural resistance-associated macrophage protein DUF420 PF04238.7 ESA16905.1 - 0.084 12.8 0.8 0.088 12.7 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF420) DUF4181 PF13789.1 ESA16905.1 - 0.096 12.6 1.3 0.12 12.3 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) DUF3611 PF12263.3 ESA16905.1 - 0.14 11.5 0.7 0.17 11.2 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF2340 PF10209.4 ESA16906.1 - 1.1e-45 154.7 2.7 1.2e-45 154.5 1.8 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Phage_hub_GP28 PF11110.3 ESA16908.1 - 0.047 13.3 0.2 0.075 12.7 0.1 1.4 1 1 0 1 1 1 0 Baseplate hub distal subunit DUF4551 PF15087.1 ESA16910.1 - 2.4 6.4 6.7 2.8 6.2 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Di19_C PF14571.1 ESA16911.1 - 4.8 7.5 10.2 0.5 10.6 1.5 2.0 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal SHIPPO-rpt PF07004.7 ESA16911.1 - 7.6 7.6 7.5 1.8 9.6 1.7 2.3 2 1 0 2 2 2 0 Sperm-tail PG-rich repeat E2 PF08199.6 ESA16912.1 - 0.075 12.6 0.9 0.16 11.6 0.6 1.6 1 0 0 1 1 1 0 Bacteriophage E2-like protein Baculo_11_kDa PF06143.6 ESA16913.1 - 0.076 12.3 1.8 0.24 10.7 1.3 1.9 1 0 0 1 1 1 0 Baculovirus 11 kDa family Sec66 PF09802.4 ESA16913.1 - 0.13 11.6 0.9 0.13 11.6 0.1 1.6 1 1 1 2 2 2 0 Preprotein translocase subunit Sec66 PEX-2N PF09263.5 ESA16916.1 - 0.04 14.2 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal DUF2913 PF11140.3 ESA16916.1 - 0.07 12.4 0.1 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2913) Transpos_assoc PF13963.1 ESA16916.1 - 0.12 12.3 1.5 0.27 11.2 1.0 1.6 1 1 0 1 1 1 0 Transposase-associated domain DBD_Tnp_Mut PF03108.10 ESA16916.1 - 0.15 11.6 1.1 0.73 9.4 0.8 2.0 1 1 0 1 1 1 0 MuDR family transposase zf-C2H2 PF00096.21 ESA16916.1 - 0.16 12.4 1.2 0.16 12.4 0.9 2.9 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA16916.1 - 0.41 11.0 6.2 4.3 7.8 0.5 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 ESA16916.1 - 3.2 8.0 6.0 0.57 10.4 1.0 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF1615 PF07759.7 ESA16918.1 - 0.085 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) Peptidase_C30 PF05409.8 ESA16918.1 - 0.096 11.7 0.2 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Coronavirus endopeptidase C30 RVT_1 PF00078.22 ESA16919.1 - 1.6e-07 30.9 0.0 0.0026 17.1 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_S15 PF02129.13 ESA16920.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Arm PF00514.18 ESA16923.1 - 1e-68 225.0 29.4 1.7e-12 46.6 0.0 11.0 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESA16923.1 - 3.1e-21 75.4 14.7 1.7e-05 25.0 0.1 7.3 2 2 5 7 7 7 7 HEAT repeats HEAT PF02985.17 ESA16923.1 - 1.5e-18 65.1 15.6 0.031 14.3 0.0 10.2 10 0 0 10 10 10 5 HEAT repeat HEAT_EZ PF13513.1 ESA16923.1 - 4.5e-12 46.0 18.0 0.019 15.4 0.1 8.7 7 2 3 10 10 9 5 HEAT-like repeat Arm_2 PF04826.8 ESA16923.1 - 5e-11 42.1 7.2 4.4e-06 26.0 2.1 3.7 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.15 ESA16923.1 - 9.9e-11 40.6 7.2 9.1e-08 30.8 0.2 2.4 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.7 ESA16923.1 - 1.7e-09 36.2 0.3 2.8e-09 35.5 0.2 1.4 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.9 ESA16923.1 - 1e-05 24.8 3.8 0.026 13.6 0.1 4.0 2 1 1 3 3 3 2 V-ATPase subunit H HEAT_PBS PF03130.11 ESA16923.1 - 0.0013 19.0 9.4 1.1 9.9 0.2 6.9 8 0 0 8 8 7 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.3 ESA16923.1 - 0.002 18.0 2.9 14 5.6 0.0 4.8 2 1 2 5 5 5 0 V-ATPase subunit H Vac14_Fab1_bd PF12755.2 ESA16923.1 - 0.0081 16.5 0.1 9.8 6.6 0.0 3.0 1 1 2 3 3 3 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.7 ESA16924.1 - 5.1e-05 23.0 0.1 0.0049 16.5 0.0 3.2 2 2 0 2 2 2 1 rRNA processing/ribosome biogenesis DUF3895 PF13034.1 ESA16924.1 - 0.031 13.7 0.0 0.19 11.2 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3895) Sel1 PF08238.7 ESA16925.1 - 1.7e-27 95.2 3.6 4.5e-07 30.2 0.2 4.1 4 0 0 4 4 4 4 Sel1 repeat MIT PF04212.13 ESA16925.1 - 0.023 14.5 2.5 5.9 6.8 0.1 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA16925.1 - 0.029 14.0 2.7 1.9 8.1 0.0 3.0 2 1 1 3 3 3 0 TPR repeat TPR_7 PF13176.1 ESA16925.1 - 0.089 12.6 0.2 3.2 7.7 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA16925.1 - 0.15 12.5 8.7 12 6.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA16925.1 - 0.19 11.3 0.1 0.19 11.3 0.1 3.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA16925.1 - 0.64 9.9 0.1 0.64 9.9 0.1 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF536 PF04394.9 ESA16925.1 - 0.77 9.5 13.8 1.9 8.2 9.5 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF536 NSF PF02071.15 ESA16925.1 - 2.1 9.2 3.8 3.9 8.4 0.1 3.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.12 ESA16925.1 - 2.9 8.0 0.0 2.9 8.0 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat HAUS-augmin3 PF14932.1 ESA16926.1 - 0.073 12.2 0.0 0.083 12.0 0.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ING PF12998.2 ESA16926.1 - 0.092 13.0 0.2 0.1 12.8 0.2 1.3 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Menin PF05053.8 ESA16929.1 - 0.0015 16.8 5.1 0.0016 16.7 3.6 1.1 1 0 0 1 1 1 1 Menin Nucleos_tra2_C PF07662.8 ESA16929.1 - 0.037 13.4 0.4 0.05 13.0 0.3 1.2 1 0 0 1 1 1 0 Na+ dependent nucleoside transporter C-terminus DUF3464 PF11947.3 ESA16929.1 - 0.045 13.2 1.0 0.057 12.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Claudin_2 PF13903.1 ESA16929.1 - 0.11 12.1 1.3 0.15 11.6 0.9 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF3385 PF11865.3 ESA16929.1 - 0.14 12.1 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) Spore_YhcN_YlaJ PF09580.5 ESA16929.1 - 0.25 11.4 15.3 0.31 11.1 10.6 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Tetraspannin PF00335.15 ESA16929.1 - 0.29 10.3 4.9 0.44 9.7 3.4 1.4 1 0 0 1 1 1 0 Tetraspanin family Pex14_N PF04695.8 ESA16929.1 - 0.54 10.2 8.4 0.59 10.1 4.9 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NRDE-2 PF08424.5 ESA16929.1 - 0.8 8.5 8.3 0.25 10.1 4.0 1.5 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference POX PF07526.6 ESA16929.1 - 4.2 7.6 5.2 5.8 7.1 3.6 1.2 1 0 0 1 1 1 0 Associated with HOX XAP5 PF04921.9 ESA16929.1 - 4.5 6.7 9.4 6.6 6.2 6.5 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator HSP90 PF00183.13 ESA16930.1 - 1.4e-164 548.4 12.7 1.4e-164 548.4 8.8 1.4 2 0 0 2 2 2 1 Hsp90 protein HATPase_c_3 PF13589.1 ESA16930.1 - 3.4e-12 46.1 0.5 3.4e-12 46.1 0.4 2.8 4 0 0 4 4 4 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA16930.1 - 1.3e-09 37.7 0.1 2.9e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TRAP_alpha PF03896.11 ESA16930.1 - 0.011 14.7 3.4 0.37 9.7 0.5 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RNase_PH_C PF03725.10 ESA16930.1 - 0.021 14.7 0.4 0.46 10.4 0.0 3.0 3 0 0 3 3 3 0 3' exoribonuclease family, domain 2 7tm_1 PF00001.16 ESA16931.1 - 7e-06 25.3 14.8 1.9e-05 23.9 9.8 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) F-box-like_2 PF13013.1 ESA16932.1 - 0.0028 17.3 0.8 1.6 8.4 0.2 2.3 1 1 1 2 2 2 2 F-box-like domain BTB PF00651.26 ESA16936.1 - 2.3e-16 59.7 0.1 4.1e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA16936.1 - 1.2e-15 57.6 2.4 2.6e-15 56.6 1.7 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16936.1 - 6.8e-05 22.6 0.9 6.8e-05 22.6 0.6 2.6 3 0 0 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA16937.1 - 3.1e-14 53.1 1.0 7.2e-14 51.9 0.7 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA16937.1 - 8.5e-09 35.3 0.1 1e-07 31.9 0.0 2.4 1 1 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA16937.1 - 3.3e-05 23.6 2.3 0.00085 19.1 0.3 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch TLD PF07534.11 ESA16938.1 - 2.2e-12 47.1 2.4 2.3e-12 47.0 0.4 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA16938.1 - 1.3e-06 28.2 3.1 0.00021 21.0 0.3 3.8 4 0 0 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA16938.1 - 2.3e-06 27.5 0.3 2.2e-05 24.3 0.1 2.3 1 1 1 2 2 2 1 BTB/POZ domain CesT PF05932.8 ESA16938.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Tir chaperone protein (CesT) family TLD PF07534.11 ESA16939.1 - 2.9e-08 33.8 1.3 5.8e-08 32.8 0.9 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA16939.1 - 3.8e-06 26.6 0.6 5.2e-05 23.0 0.1 2.8 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA16939.1 - 6.6e-05 22.8 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Peptidase_S8 PF00082.17 ESA16940.1 - 4.4e-40 137.6 3.7 6.1e-40 137.1 2.6 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA16940.1 - 1.4e-05 25.5 0.0 3.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Hrs_helical PF12210.3 ESA16940.1 - 0.094 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Peptidase_S8 PF00082.17 ESA16941.1 - 3.3e-43 147.8 9.0 4.7e-43 147.3 6.3 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA16941.1 - 3e-06 27.7 0.0 6.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.17 ESA16942.1 - 3.6e-40 137.8 8.0 4.6e-40 137.5 5.5 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA16942.1 - 0.011 16.2 0.1 0.025 15.1 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 SLH PF00395.15 ESA16942.1 - 0.037 13.7 0.0 0.15 11.8 0.0 2.1 1 0 0 1 1 1 0 S-layer homology domain HCNGP PF07818.8 ESA16943.1 - 5.2e-29 100.1 1.6 8.7e-29 99.4 0.1 2.1 2 0 0 2 2 2 1 HCNGP-like protein DUF605 PF04652.11 ESA16943.1 - 1.1 8.6 13.9 1.4 8.1 9.6 1.1 1 0 0 1 1 1 0 Vta1 like Peptidase_C13 PF01650.13 ESA16944.1 - 2.4e-30 105.6 0.1 3.2e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family Pkinase_Tyr PF07714.12 ESA16945.1 - 6e-39 133.6 0.0 1.3e-38 132.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16945.1 - 2.7e-31 108.6 0.0 5.7e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Viral_NABP PF05515.6 ESA16945.1 - 0.013 15.8 1.5 0.035 14.3 1.0 1.7 1 0 0 1 1 1 0 Viral nucleic acid binding DUF4419 PF14388.1 ESA16946.1 - 5e-51 173.6 4.0 7.1e-28 97.6 0.4 2.6 2 1 1 3 3 3 2 Domain of unknown function (DUF4419) OSTMP1 PF09777.4 ESA16947.1 - 0.074 12.2 0.0 0.077 12.1 0.0 1.0 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Phage_T4_Gp30_7 PF06919.6 ESA16947.1 - 0.092 12.7 0.1 0.095 12.6 0.1 1.0 1 0 0 1 1 1 0 Phage Gp30.7 protein F-box-like PF12937.2 ESA16948.1 - 0.0016 18.1 0.8 0.0048 16.5 0.6 1.8 1 0 0 1 1 1 1 F-box-like LUC7 PF03194.10 ESA16949.1 - 0.022 14.3 0.5 0.025 14.1 0.3 1.1 1 0 0 1 1 1 0 LUC7 N_terminus DUF3529 PF12046.3 ESA16949.1 - 0.049 12.6 0.1 0.064 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3529) Syntaxin-6_N PF09177.6 ESA16949.1 - 0.05 14.0 1.6 0.4 11.0 1.1 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Spore_III_AB PF09548.5 ESA16949.1 - 0.073 12.8 0.4 0.1 12.3 0.3 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) EF-hand_10 PF14788.1 ESA16949.1 - 0.13 11.9 1.6 0.36 10.5 1.1 1.8 1 1 0 1 1 1 0 EF hand RFC1 PF08519.7 ESA16949.1 - 0.16 11.6 0.8 0.35 10.6 0.7 1.5 1 1 0 1 1 1 0 Replication factor RFC1 C terminal domain DUF2833 PF11090.3 ESA16949.1 - 0.66 10.1 2.3 27 4.9 0.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2833) Pkinase_Tyr PF07714.12 ESA16950.1 - 5.2e-48 163.3 0.0 8.1e-48 162.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16950.1 - 7.2e-48 162.9 0.4 1.4e-47 162.0 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA16950.1 - 0.0012 18.2 6.7 0.0013 18.1 0.1 2.5 2 1 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA16950.1 - 0.0043 16.0 0.0 0.012 14.5 0.0 1.8 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 ESA16950.1 - 0.0044 16.1 0.0 0.0075 15.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA16950.1 - 0.014 15.1 0.6 0.024 14.3 0.4 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA16951.1 - 8.4e-59 194.7 15.1 3.8e-10 40.0 0.1 7.1 7 0 0 7 7 7 7 Sel1 repeat TPR_11 PF13414.1 ESA16951.1 - 0.0024 17.4 29.6 0.13 11.9 1.0 5.3 1 1 5 6 6 6 6 TPR repeat MIT PF04212.13 ESA16951.1 - 0.0031 17.3 20.7 4 7.3 1.4 7.1 4 3 3 7 7 7 3 MIT (microtubule interacting and transport) domain DUF4500 PF14937.1 ESA16951.1 - 0.0062 16.3 0.3 2.3 8.0 0.0 3.8 2 1 3 5 5 5 1 Domain of unknown function (DUF4500) DUF3326 PF11805.3 ESA16951.1 - 0.034 12.8 0.0 0.05 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) TPR_7 PF13176.1 ESA16951.1 - 0.21 11.4 0.0 0.21 11.4 0.0 5.7 7 2 2 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA16951.1 - 1.2 9.0 26.9 9.7 6.2 3.1 6.2 1 1 5 6 6 6 0 Tetratricopeptide repeat BACK PF07707.10 ESA16953.1 - 3.7e-07 29.9 2.5 1.5e-06 27.9 0.4 2.5 1 1 2 3 3 3 1 BTB And C-terminal Kelch Thioredoxin PF00085.15 ESA16954.1 - 6.7e-52 173.5 0.6 8.7e-25 86.4 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 ESA16954.1 - 1.8e-22 80.0 0.2 1.7e-17 63.8 0.0 3.4 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 ESA16954.1 - 1.3e-10 41.2 4.7 0.073 13.1 0.1 5.0 3 2 1 4 4 4 3 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA16954.1 - 1.7e-06 28.1 2.8 0.14 12.3 0.1 4.4 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_3 PF13192.1 ESA16954.1 - 1.1e-05 25.0 0.1 0.29 10.9 0.0 3.2 4 0 0 4 4 4 2 Thioredoxin domain Thioredoxin_7 PF13899.1 ESA16954.1 - 0.00018 21.4 0.3 0.88 9.6 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like TraF PF13728.1 ESA16954.1 - 0.0017 17.8 0.0 0.58 9.6 0.0 3.7 4 0 0 4 4 4 1 F plasmid transfer operon protein Thioredoxin_5 PF13743.1 ESA16954.1 - 0.0052 16.3 0.6 3.9 6.9 0.0 3.5 3 1 0 3 3 3 1 Thioredoxin Thioredoxin_9 PF14595.1 ESA16954.1 - 0.031 13.8 0.4 0.55 9.8 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin zf-FPG_IleRS PF06827.9 ESA16954.1 - 0.93 9.1 5.7 3.6 7.3 0.4 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Peptidase_S8 PF00082.17 ESA16955.1 - 5.7e-44 150.3 7.9 8.3e-44 149.8 5.5 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 ESA16955.1 - 8.5e-05 23.0 0.0 0.00019 21.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Hom_end_hint PF05203.11 ESA16956.1 - 0.00029 20.6 1.1 0.00034 20.4 0.8 1.0 1 0 0 1 1 1 1 Hom_end-associated Hint IER PF05760.7 ESA16956.1 - 0.019 14.8 0.3 0.022 14.6 0.2 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) CAML PF14963.1 ESA16956.1 - 0.23 10.8 1.7 0.26 10.6 1.2 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Rad60-SLD PF11976.3 ESA16957.1 - 0.12 12.0 1.2 0.36 10.5 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Abhydrolase_3 PF07859.8 ESA16958.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Metallophos PF00149.23 ESA16958.1 - 0.045 13.1 0.1 0.047 13.0 0.1 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase AAA PF00004.24 ESA16959.1 - 1.8e-62 209.3 0.0 2.3e-42 144.3 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA16959.1 - 2.8e-09 37.2 4.4 0.0032 17.4 0.1 4.0 3 2 1 4 4 4 2 AAA ATPase domain AAA_5 PF07728.9 ESA16959.1 - 1.2e-07 31.5 0.0 0.0061 16.2 0.0 3.4 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA16959.1 - 2.9e-07 30.4 0.0 0.033 14.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 ESA16959.1 - 1.4e-06 28.4 0.7 0.0018 18.4 0.1 3.6 2 2 1 3 3 3 1 AAA domain AAA_17 PF13207.1 ESA16959.1 - 1.7e-06 28.8 0.0 0.0025 18.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 ESA16959.1 - 4.8e-06 25.8 0.0 0.0015 17.5 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 ESA16959.1 - 2.3e-05 23.8 1.0 0.042 13.2 0.1 3.1 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.1 ESA16959.1 - 2.4e-05 24.2 0.0 0.06 13.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESA16959.1 - 4.3e-05 23.1 0.2 0.0016 18.1 0.0 2.7 3 0 0 3 3 2 1 Part of AAA domain IstB_IS21 PF01695.12 ESA16959.1 - 7.9e-05 22.1 0.1 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.17 ESA16959.1 - 9e-05 22.6 0.0 0.034 14.3 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Sigma54_activat PF00158.21 ESA16959.1 - 0.00048 19.6 0.0 0.49 9.8 0.0 3.1 4 0 0 4 4 3 1 Sigma-54 interaction domain NACHT PF05729.7 ESA16959.1 - 0.00052 19.7 0.2 1 8.9 0.0 3.2 3 0 0 3 3 3 1 NACHT domain TIP49 PF06068.8 ESA16959.1 - 0.00066 18.5 0.0 0.0073 15.0 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus Mg_chelatase PF01078.16 ESA16959.1 - 0.00091 18.4 0.4 0.0097 15.0 0.1 2.4 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 ESA16959.1 - 0.00094 19.1 0.0 0.0055 16.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 ESA16959.1 - 0.0018 17.2 0.0 0.58 9.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 ESA16959.1 - 0.0022 17.9 0.1 0.054 13.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA16959.1 - 0.0027 18.0 0.0 0.042 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA16959.1 - 0.0027 17.3 0.0 1 8.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESA16959.1 - 0.0033 17.0 0.9 0.035 13.6 0.1 2.7 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.1 ESA16959.1 - 0.0043 17.1 0.0 0.72 9.9 0.0 3.0 3 1 0 3 3 2 1 Sigma-54 interaction domain KaiC PF06745.8 ESA16959.1 - 0.0047 16.0 0.3 0.02 13.9 0.0 2.1 3 0 0 3 3 2 1 KaiC Parvo_NS1 PF01057.12 ESA16959.1 - 0.0063 15.4 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 ESA16959.1 - 0.0093 15.5 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 PhoH PF02562.11 ESA16959.1 - 0.013 14.7 0.2 0.042 13.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein NB-ARC PF00931.17 ESA16959.1 - 0.016 14.1 0.0 0.66 8.7 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ABC_tran PF00005.22 ESA16959.1 - 0.017 15.4 0.0 3.8 7.8 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_3 PF07726.6 ESA16959.1 - 0.018 14.6 0.0 0.16 11.5 0.0 2.4 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 ESA16959.1 - 0.02 13.5 0.0 0.19 10.3 0.0 2.0 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein T2SE PF00437.15 ESA16959.1 - 0.029 13.2 0.3 2.8 6.7 0.0 2.6 2 1 0 3 3 3 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 ESA16959.1 - 0.037 13.7 0.1 3.4 7.3 0.0 2.7 2 1 1 3 3 3 0 Archaeal ATPase Zeta_toxin PF06414.7 ESA16959.1 - 0.052 12.6 0.0 0.24 10.4 0.0 2.1 3 0 0 3 3 3 0 Zeta toxin NTPase_1 PF03266.10 ESA16959.1 - 0.071 12.8 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA_29 PF13555.1 ESA16959.1 - 0.11 12.0 0.1 13 5.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.1 ESA16959.1 - 0.11 12.0 0.1 0.6 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.4 ESA16959.1 - 0.11 11.3 0.0 3.4 6.5 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 SKI PF01202.17 ESA16959.1 - 0.12 12.2 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase Vps4_C PF09336.5 ESA16960.1 - 0.00058 19.7 0.3 0.0031 17.3 0.2 2.0 1 1 0 1 1 1 1 Vps4 C terminal oligomerisation domain DUF3770 PF12603.3 ESA16960.1 - 0.12 11.4 0.2 2.8 6.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3770) Pkinase_Tyr PF07714.12 ESA16961.1 - 1.5e-13 50.4 0.0 1.7e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16961.1 - 2.8e-12 46.3 0.0 3.3e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA16962.1 - 7.1e-29 100.7 0.2 9e-29 100.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16962.1 - 1.1e-26 93.5 0.0 1.3e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA16962.1 - 1.7e-05 24.7 0.0 2.3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA16962.1 - 0.0011 18.2 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA16962.1 - 0.017 14.4 0.3 0.049 12.9 0.0 1.8 1 1 1 2 2 2 0 RIO1 family Kdo PF06293.9 ESA16962.1 - 0.026 13.6 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESA16962.1 - 0.029 13.2 0.2 0.065 12.0 0.1 1.7 1 1 1 2 2 2 0 Seadornavirus VP7 Choline_kinase PF01633.15 ESA16962.1 - 0.03 13.9 0.1 0.069 12.7 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase MFS_1 PF07690.11 ESA16963.1 - 1.3e-37 129.3 31.6 1.4e-37 129.2 21.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Pkinase_Tyr PF07714.12 ESA16965.1 - 1.8e-20 73.1 0.0 2.4e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA16965.1 - 8.7e-20 70.9 0.4 3.1e-19 69.1 0.3 1.8 1 1 0 1 1 1 1 Protein kinase domain Integrin_B_tail PF07965.7 ESA16965.1 - 0.09 13.2 2.0 0.16 12.4 1.4 1.4 1 0 0 1 1 1 0 Integrin beta tail domain CBM_20 PF00686.14 ESA16966.1 - 0.0063 16.0 0.0 0.02 14.4 0.0 1.8 1 0 0 1 1 1 1 Starch binding domain p450 PF00067.17 ESA16967.1 - 3.4e-44 151.1 1.3 6.2e-44 150.2 0.9 1.4 1 1 0 1 1 1 1 Cytochrome P450 BTB PF00651.26 ESA16968.1 - 1.4e-21 76.5 0.4 2.6e-21 75.6 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain LAG1-DNAbind PF09271.6 ESA16968.1 - 0.0087 16.5 0.1 0.024 15.1 0.1 1.7 1 0 0 1 1 1 1 LAG1, DNA binding ADAM_spacer1 PF05986.9 ESA16968.1 - 0.09 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 ADAM-TS Spacer 1 DUF4449 PF14613.1 ESA16969.1 - 0.00013 21.9 0.7 0.00013 21.9 0.5 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF4449) DUF4363 PF14276.1 ESA16969.1 - 0.037 13.7 7.7 1.9 8.2 0.6 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) Papo_T_antigen PF02380.10 ESA16971.1 - 0.11 12.3 0.7 0.17 11.7 0.5 1.2 1 0 0 1 1 1 0 T-antigen specific domain Pkinase PF00069.20 ESA16973.1 - 8.8e-27 93.8 4.9 7.7e-24 84.2 0.1 2.8 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA16973.1 - 1.1e-22 80.4 0.6 2e-16 59.8 0.0 2.6 2 1 1 3 3 3 2 Protein tyrosine kinase APH PF01636.18 ESA16973.1 - 0.00049 19.9 0.1 0.0014 18.4 0.1 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA16973.1 - 0.0034 16.7 0.0 0.0034 16.7 0.0 2.6 2 1 0 3 3 3 1 RIO1 family COG2 PF06148.6 ESA16973.1 - 0.0045 16.8 1.9 0.01 15.7 1.3 1.6 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 CENP-Q PF13094.1 ESA16973.1 - 0.033 14.2 9.0 0.027 14.5 4.6 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Kdo PF06293.9 ESA16973.1 - 0.07 12.1 0.2 0.13 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GLE1 PF07817.8 ESA16973.1 - 0.11 11.4 3.0 0.18 10.6 2.1 1.3 1 0 0 1 1 1 0 GLE1-like protein IncA PF04156.9 ESA16973.1 - 0.25 10.9 6.2 0.49 9.9 4.3 1.4 1 0 0 1 1 1 0 IncA protein Med9 PF07544.8 ESA16973.1 - 0.44 10.3 7.9 1.1 9.0 5.5 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Syntaxin PF00804.20 ESA16973.1 - 1.5 8.9 11.2 3.7 7.7 4.5 2.5 2 0 0 2 2 2 0 Syntaxin Atg14 PF10186.4 ESA16973.1 - 3 6.7 9.9 7.6 5.3 6.8 1.7 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 zf-C4H2 PF10146.4 ESA16973.1 - 5.1 7.0 16.3 0.93 9.4 8.6 1.6 2 0 0 2 2 2 0 Zinc finger-containing protein DUF812 PF05667.6 ESA16973.1 - 9.2 4.6 12.4 1.9 6.8 5.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Mac PF12464.3 ESA16975.1 - 2.5e-15 56.2 0.2 5.4e-15 55.1 0.0 1.6 2 0 0 2 2 2 1 Maltose acetyltransferase Hexapep PF00132.19 ESA16975.1 - 1.1e-12 46.7 13.7 2.1e-10 39.6 4.3 3.6 4 1 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESA16975.1 - 1.5e-12 46.7 8.9 1.1e-10 40.8 3.1 3.1 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Acetyltransf_11 PF13720.1 ESA16975.1 - 0.0037 17.4 1.2 0.02 15.1 0.1 2.3 2 1 1 3 3 3 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Pkinase_Tyr PF07714.12 ESA16977.1 - 1.3e-26 93.2 0.1 1.3e-20 73.5 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA16977.1 - 1.1e-23 83.7 4.8 1.1e-22 80.4 0.2 2.8 3 0 0 3 3 3 2 Protein kinase domain BCS1_N PF08740.6 ESA16977.1 - 3.4e-12 46.3 0.1 0.03 13.9 0.0 4.3 4 0 0 4 4 4 3 BCS1 N terminal DUF4413 PF14372.1 ESA16977.1 - 0.087 12.8 6.0 4.4 7.3 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) Cas_Cas4 PF01930.12 ESA16979.1 - 0.00014 21.8 3.0 0.00062 19.7 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.2 ESA16979.1 - 0.0029 17.0 0.4 0.0029 17.0 0.3 3.1 2 1 1 3 3 3 2 PD-(D/E)XK nuclease superfamily COQ9 PF08511.6 ESA16980.1 - 1e-30 105.0 0.5 1.6e-30 104.4 0.3 1.3 1 0 0 1 1 1 1 COQ9 OTT_1508_deam PF14441.1 ESA16984.1 - 1.5e-09 37.7 1.3 2.5e-09 37.0 0.4 1.8 2 0 0 2 2 2 1 OTT_1508-like deaminase Ribos_L4_asso_C PF14374.1 ESA16984.1 - 0.033 14.0 1.1 2.1 8.3 0.0 2.9 2 0 0 2 2 2 0 60S ribosomal protein L4 C-terminal domain DUF496 PF04363.7 ESA16984.1 - 0.2 11.5 8.0 1.5 8.6 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF496) zf-U1 PF06220.7 ESA16985.1 - 0.0085 15.6 2.2 0.021 14.3 1.6 1.6 1 0 0 1 1 1 1 U1 zinc finger AAA_12 PF13087.1 ESA16986.1 - 5.1e-12 45.5 0.6 5.1e-12 45.5 0.4 1.7 2 0 0 2 2 2 1 AAA domain DUF3211 PF11485.3 ESA16986.1 - 0.53 10.3 5.7 10 6.1 4.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3211) YhhN PF07947.9 ESA16987.1 - 0.00032 20.1 7.0 0.0012 18.2 4.9 1.9 1 1 0 1 1 1 1 YhhN-like protein HABP4_PAI-RBP1 PF04774.10 ESA16988.1 - 0.0012 19.3 0.2 0.0016 18.9 0.1 1.5 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family HD_assoc PF13286.1 ESA16989.1 - 0.12 12.6 1.1 0.18 12.0 0.8 1.3 1 1 0 1 1 1 0 Phosphohydrolase-associated domain DUF2573 PF10835.3 ESA16989.1 - 0.16 12.0 3.0 0.31 11.1 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2573) Fzo_mitofusin PF04799.8 ESA16990.1 - 2.1 7.7 7.8 1.2 8.4 0.2 2.9 2 1 1 3 3 3 0 fzo-like conserved region Adaptin_binding PF10199.4 ESA16990.1 - 4.7 7.4 8.0 93 3.2 5.6 2.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF4094 PF13334.1 ESA16991.1 - 0.16 12.3 4.3 0.32 11.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) DUF1192 PF06698.6 ESA16991.1 - 0.41 10.5 2.7 28 4.6 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) TMF_TATA_bd PF12325.3 ESA16991.1 - 4.1 7.1 13.0 0.31 10.7 4.5 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding YyzF PF14116.1 ESA16991.1 - 6.6 6.7 8.3 48 4.0 0.0 4.1 4 0 0 4 4 4 0 YyzF-like protein Retrotrans_gag PF03732.12 ESA16992.1 - 3.1e-08 33.5 0.0 8.3e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC PF00098.18 ESA16992.1 - 4.2e-06 26.4 2.1 4.2e-06 26.4 1.5 2.7 3 0 0 3 3 3 1 Zinc knuckle UBN2 PF14223.1 ESA16992.1 - 0.0011 18.7 1.8 0.0024 17.6 0.0 2.6 3 1 1 4 4 4 1 gag-polypeptide of LTR copia-type zf-CCHC_4 PF14392.1 ESA16992.1 - 0.14 11.8 3.1 0.09 12.4 0.3 2.2 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.1 ESA16992.1 - 2.4 7.8 3.8 5.9 6.6 2.7 1.6 1 0 0 1 1 1 0 Zinc knuckle Spc7 PF08317.6 ESA16993.1 - 0.0025 16.5 3.5 0.003 16.2 2.4 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein BLOC1_2 PF10046.4 ESA16993.1 - 0.043 13.9 1.0 0.086 12.9 0.7 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3544 PF12064.3 ESA16993.1 - 1.6 8.4 6.7 2.3 7.9 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3544) BTB PF00651.26 ESA16994.1 - 4.5e-22 78.1 0.2 5.6e-22 77.8 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA16994.1 - 0.0011 18.1 0.1 0.0014 17.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Urm1 PF09138.6 ESA16994.1 - 0.03 14.4 0.1 0.069 13.2 0.1 1.7 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Skp1_POZ PF03931.10 ESA16994.1 - 0.079 13.0 0.2 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain BTB_2 PF02214.17 ESA16994.1 - 0.084 13.0 0.2 0.19 11.9 0.0 1.8 1 1 1 2 2 2 0 BTB/POZ domain DUF4325 PF14213.1 ESA16994.1 - 0.099 12.3 0.1 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4325) TLD PF07534.11 ESA16995.1 - 2.5e-11 43.7 1.6 4e-11 43.0 0.9 1.5 2 0 0 2 2 2 1 TLD SH2 PF00017.19 ESA16995.1 - 0.093 12.5 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 SH2 domain RasGEF_N PF00618.15 ESA16995.1 - 0.1 12.7 0.2 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 RasGEF N-terminal motif TLD PF07534.11 ESA16996.1 - 1.7e-08 34.5 0.3 2.6e-07 30.6 0.2 2.2 1 1 0 1 1 1 1 TLD YihI PF04220.7 ESA16999.1 - 0.057 12.7 3.3 0.075 12.3 2.3 1.3 1 1 0 1 1 1 0 Der GTPase activator (YihI) Dynamin_N PF00350.18 ESA17000.1 - 1.9e-17 63.5 0.2 1.9e-17 63.5 0.1 3.6 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.18 ESA17000.1 - 3.8e-12 46.1 4.1 1.7e-11 44.0 0.2 3.8 3 2 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA17000.1 - 4.4e-08 32.7 4.9 5.2e-08 32.5 0.6 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 ESA17000.1 - 1.8e-05 25.2 0.3 0.0011 19.4 0.2 3.0 1 1 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 ESA17000.1 - 0.01 15.3 0.0 2.5 7.6 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF258 PF03193.11 ESA17000.1 - 0.014 14.5 0.1 0.069 12.3 0.1 2.2 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PglZ PF08665.7 ESA17000.1 - 0.015 14.9 3.1 0.15 11.7 0.1 3.0 2 0 0 2 2 2 0 PglZ domain AAA_29 PF13555.1 ESA17000.1 - 0.019 14.4 0.0 0.052 13.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_32 PF13654.1 ESA17000.1 - 0.029 13.0 13.7 1.3 7.5 4.6 3.8 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA17000.1 - 0.045 13.2 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family SynMuv_product PF06047.6 ESA17001.1 - 2.3e-51 171.9 3.4 2.3e-51 171.9 2.4 2.5 2 1 0 2 2 2 1 Ras-induced vulval development antagonist Dsh_C PF12316.3 ESA17001.1 - 0.27 11.3 8.5 0.54 10.3 5.9 1.6 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4614 PF15391.1 ESA17001.1 - 1.4 8.6 15.3 2.7 7.7 10.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Hid1 PF12722.2 ESA17001.1 - 4.5 4.8 14.8 7.5 4.0 10.2 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pkinase_Tyr PF07714.12 ESA17002.1 - 4.3e-19 68.5 0.0 5.9e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17002.1 - 4.4e-10 39.1 0.0 6.5e-10 38.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain DnaB_2 PF07261.6 ESA17002.1 - 0.015 14.8 0.1 0.032 13.8 0.1 1.6 1 0 0 1 1 1 0 Replication initiation and membrane attachment PI3_PI4_kinase PF00454.22 ESA17002.1 - 0.053 12.9 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Pkinase_Tyr PF07714.12 ESA17003.1 - 0.0007 18.7 0.0 0.00094 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17003.1 - 0.014 14.5 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Rep_N PF08724.5 ESA17003.1 - 0.091 12.2 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Rep protein catalytic domain like Pkinase_Tyr PF07714.12 ESA17004.1 - 2.8e-26 92.1 0.0 7.2e-25 87.5 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17004.1 - 7.8e-22 77.6 0.1 2.8e-21 75.8 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain DUF2348 PF09807.4 ESA17005.1 - 1.2e-40 139.2 3.1 3.8e-39 134.2 2.1 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2348) Elong_Iki1 PF10483.4 ESA17005.1 - 2.2e-05 23.9 4.1 0.00016 21.1 2.8 2.1 1 1 0 1 1 1 1 Elongator subunit Iki1 KaiC PF06745.8 ESA17005.1 - 0.0002 20.5 0.2 0.00029 20.0 0.1 1.3 1 0 0 1 1 1 1 KaiC TFIIA PF03153.8 ESA17006.1 - 3.4e-48 165.4 31.7 7.5e-32 111.6 19.2 2.5 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Peptidase_M48 PF01435.13 ESA17007.1 - 1.9e-13 50.5 0.0 3e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 DUF45 PF01863.12 ESA17007.1 - 0.0066 16.2 0.4 0.027 14.2 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function DUF45 HPS3_Mid PF14762.1 ESA17007.1 - 0.028 13.0 0.0 0.044 12.3 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, middle region Peptidase_MA_2 PF13485.1 ESA17007.1 - 0.11 12.5 0.1 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase MA superfamily Pkinase_Tyr PF07714.12 ESA17008.1 - 4.3e-13 48.9 0.1 4.3e-13 48.9 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase MCPsignal PF00015.16 ESA17008.1 - 0.026 14.0 7.4 0.2 11.1 2.7 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain End3 PF12761.2 ESA17008.1 - 0.13 11.8 11.8 0.069 12.7 4.5 2.5 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 KxDL PF10241.4 ESA17008.1 - 0.78 9.6 9.9 0.24 11.3 2.6 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF848 PF05852.6 ESA17008.1 - 1.8 8.4 12.4 0.27 11.0 3.7 2.7 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Reo_sigmaC PF04582.7 ESA17008.1 - 2 7.5 7.2 4 6.5 1.6 2.2 1 1 0 2 2 2 0 Reovirus sigma C capsid protein SlyX PF04102.7 ESA17008.1 - 2.4 8.5 7.3 1.6 9.1 3.4 2.1 2 0 0 2 2 2 0 SlyX Pkinase_Tyr PF07714.12 ESA17009.1 - 8.6e-08 31.5 0.1 9.1e-08 31.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17009.1 - 3.6e-07 29.5 0.0 3.9e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain CoA_transf_3 PF02515.12 ESA17010.1 - 1.4e-48 164.6 0.0 1.7e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III MARVEL PF01284.18 ESA17011.1 - 0.025 14.3 0.5 0.04 13.7 0.3 1.4 1 1 0 1 1 1 0 Membrane-associating domain EF-hand_7 PF13499.1 ESA17012.1 - 4.3e-10 39.5 3.4 7.1e-10 38.8 2.3 1.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESA17012.1 - 3e-09 35.7 0.2 0.00075 18.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 ESA17012.1 - 3.4e-09 35.3 1.9 0.00018 20.5 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESA17012.1 - 1.6e-08 33.7 2.8 8.5e-06 25.2 0.4 2.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ESA17012.1 - 9e-07 28.4 4.9 0.0044 16.5 0.7 2.5 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESA17012.1 - 0.0011 19.0 0.3 0.0079 16.2 0.2 1.9 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.13 ESA17012.1 - 0.076 12.7 5.8 0.64 9.8 0.3 2.5 2 0 0 2 2 2 0 Dockerin type I repeat FG-GAP PF01839.18 ESA17012.1 - 0.42 10.3 2.1 2.7 7.7 0.1 2.3 2 0 0 2 2 2 0 FG-GAP repeat Chalcone PF02431.10 ESA17013.1 - 8.6e-45 152.5 0.0 1.2e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Chalcone-flavanone isomerase TetR PF13972.1 ESA17013.1 - 0.012 15.0 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial transcriptional repressor AdoHcyase PF05221.12 ESA17014.1 - 1.1e-141 470.4 0.1 1.3e-141 470.2 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 ESA17014.1 - 3.6e-85 283.7 2.9 6.1e-85 283.0 2.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 ESA17014.1 - 5.7e-09 35.3 0.3 1.8e-08 33.7 0.2 1.8 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESA17014.1 - 8.5e-05 21.9 0.3 0.00014 21.3 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain ELFV_dehydrog PF00208.16 ESA17014.1 - 0.0025 17.4 0.2 0.0045 16.5 0.1 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.13 ESA17014.1 - 0.027 14.4 0.1 0.078 12.9 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain DUF4448 PF14610.1 ESA17014.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SNAP PF14938.1 ESA17015.1 - 4.9e-113 376.9 20.5 5.6e-113 376.7 14.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.1 ESA17015.1 - 7.4e-08 31.9 17.4 0.0058 16.2 0.4 4.1 1 1 3 4 4 4 4 TPR repeat TPR_7 PF13176.1 ESA17015.1 - 4.6e-07 29.1 11.4 0.17 11.7 0.1 6.1 5 1 1 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17015.1 - 6.1e-07 29.2 17.3 6.8e-05 22.7 0.4 3.1 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA17015.1 - 5.8e-06 25.8 23.1 0.23 11.4 0.1 7.3 5 2 3 8 8 8 3 Tetratricopeptide repeat Spatacsin_C PF14649.1 ESA17015.1 - 0.00026 19.9 4.8 0.13 11.0 0.2 2.3 1 1 1 2 2 2 2 Spatacsin C-terminus TPR_1 PF00515.23 ESA17015.1 - 0.00051 19.5 18.6 0.23 11.1 0.1 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESA17015.1 - 0.014 15.3 3.0 2.7 8.0 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17015.1 - 0.023 15.3 16.2 0.62 10.8 0.1 4.6 3 1 2 5 5 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA17015.1 - 0.058 13.2 8.9 1.4 8.8 0.1 4.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.4 ESA17015.1 - 0.074 12.3 0.3 2 7.7 0.0 2.8 2 0 0 2 2 2 0 SHNi-TPR TPR_6 PF13174.1 ESA17015.1 - 0.15 12.6 13.2 1.5 9.4 0.1 5.8 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17015.1 - 0.35 10.7 21.5 1.2 9.1 0.1 6.3 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17015.1 - 0.49 11.1 13.8 5.2 7.9 0.0 5.9 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA17015.1 - 6.5 7.1 19.5 0.72 10.2 0.9 4.4 2 1 3 5 5 5 0 Tetratricopeptide repeat BCDHK_Adom3 PF10436.4 ESA17016.1 - 3.6e-45 153.4 0.1 6.8e-45 152.5 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 ESA17016.1 - 1.4e-15 56.9 0.0 5e-14 51.9 0.0 2.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESA17016.1 - 0.0021 17.6 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GLF PF03275.8 ESA17016.1 - 0.021 14.3 0.1 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 UDP-galactopyranose mutase ATP-synt_F PF01990.12 ESA17016.1 - 0.13 12.6 0.4 10 6.5 0.0 2.9 2 1 1 3 3 3 0 ATP synthase (F/14-kDa) subunit Pkinase PF00069.20 ESA17017.1 - 1.7e-71 240.4 0.1 3.1e-71 239.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17017.1 - 3.1e-30 105.1 0.2 3.9e-29 101.4 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA17017.1 - 8.6e-08 31.4 1.3 0.00057 18.9 0.0 3.1 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 ESA17017.1 - 0.037 13.7 0.0 0.28 10.8 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA17017.1 - 0.053 12.5 0.0 0.089 11.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MCR_beta PF02241.13 ESA17017.1 - 0.17 11.0 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain BTB PF00651.26 ESA17020.1 - 1.6e-18 66.6 0.2 3e-18 65.8 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17020.1 - 5.2e-06 26.2 0.4 0.00034 20.4 0.2 3.0 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA17023.1 - 2.1e-21 75.9 0.6 8e-21 74.1 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA17023.1 - 0.00031 20.7 0.2 0.26 11.3 0.0 2.7 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain Urease_gamma PF00547.13 ESA17023.1 - 0.0062 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Urease, gamma subunit CompInhib_SCIN PF11546.3 ESA17023.1 - 0.36 10.6 3.4 0.33 10.8 0.4 2.3 3 0 0 3 3 3 0 Staphylococcal complement inhibitor SCIN Ras PF00071.17 ESA17024.1 - 8.8e-56 187.7 0.0 1e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA17024.1 - 2.9e-18 66.4 0.0 4.6e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA17024.1 - 1.9e-07 30.5 0.0 2.6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA17024.1 - 0.00016 21.1 0.0 0.0016 17.8 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain COG7 PF10191.4 ESA17025.1 - 1.7e-109 366.8 7.4 2.1e-93 313.6 2.1 3.0 2 1 0 2 2 2 2 Golgi complex component 7 (COG7) Reo_sigmaC PF04582.7 ESA17025.1 - 0.0092 15.1 2.3 0.025 13.7 1.6 1.7 1 0 0 1 1 1 1 Reovirus sigma C capsid protein LMSTEN PF07988.7 ESA17025.1 - 2.9 7.2 8.5 0.15 11.3 1.5 2.2 2 0 0 2 2 2 0 LMSTEN motif TLD PF07534.11 ESA17026.1 - 2.1e-09 37.4 0.1 5.5e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA17027.1 - 4e-17 62.2 0.2 2.5e-07 30.6 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain SR-25 PF10500.4 ESA17027.1 - 8.4 5.7 10.3 14 5.0 7.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein BacA PF02673.13 ESA17028.1 - 0.045 12.9 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacitracin resistance protein BacA PgaD PF13994.1 ESA17028.1 - 0.046 13.1 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 PgaD-like protein PetG PF02529.10 ESA17028.1 - 0.062 12.8 0.1 2 7.9 0.1 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit 5 DUF4500 PF14937.1 ESA17028.1 - 0.065 13.0 0.2 0.16 11.7 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) LRR_4 PF12799.2 ESA17029.1 - 1.3 8.7 8.0 13 5.5 0.2 4.4 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA17029.1 - 2.3 8.5 7.8 1.3 9.3 0.1 4.3 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 ESA17029.1 - 9.1 6.9 7.0 8 7.1 0.1 4.4 6 0 0 6 6 6 0 Leucine rich repeat DUF2605 PF10792.4 ESA17030.1 - 0.076 12.6 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Sel1 PF08238.7 ESA17031.1 - 5.2e-66 217.6 20.8 2.2e-09 37.6 0.6 9.5 10 0 0 10 10 10 8 Sel1 repeat TPR_16 PF13432.1 ESA17031.1 - 0.26 11.9 9.5 14 6.5 0.4 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Myb_DNA-binding PF00249.26 ESA17032.1 - 7.1e-06 25.9 0.4 1.2e-05 25.2 0.3 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Sugarporin_N PF11471.3 ESA17032.1 - 0.035 13.7 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Myb_DNA-bind_6 PF13921.1 ESA17032.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain 7TM_GPCR_Sri PF10327.4 ESA17033.1 - 0.0081 15.1 3.9 0.011 14.7 2.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Sri ArfGap PF01412.13 ESA17034.1 - 3.8e-35 120.1 0.6 3.8e-35 120.1 0.4 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BTB PF00651.26 ESA17035.1 - 5e-16 58.6 0.1 1e-15 57.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA17035.1 - 1.9e-12 47.3 0.8 4.2e-12 46.2 0.6 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA17035.1 - 2.2e-05 24.2 2.6 0.0021 17.8 0.2 4.1 3 2 1 4 4 4 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA17036.1 - 2.9e-40 137.9 0.0 3.6e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17036.1 - 2.2e-38 131.9 0.0 3.8e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA17036.1 - 0.09 12.3 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 BCS1 N terminal APH PF01636.18 ESA17036.1 - 0.16 11.7 0.2 0.36 10.5 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family MIR PF02815.14 ESA17037.1 - 0.054 13.0 0.1 1.2 8.5 0.0 2.4 1 1 2 3 3 3 0 MIR domain BTB PF00651.26 ESA17038.1 - 5.6e-18 64.9 0.3 1.1e-17 64.0 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17038.1 - 0.0019 18.0 4.1 0.012 15.3 1.0 3.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3311 PF11755.3 ESA17039.1 - 0.097 12.2 9.9 0.05 13.1 1.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3311) DUF2613 PF11021.3 ESA17039.1 - 1.3 8.7 5.4 4.5 7.0 0.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) bZIP_1 PF00170.16 ESA17040.1 - 5.9e-06 26.1 4.1 8.9e-06 25.5 2.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor SMN PF06003.7 ESA17040.1 - 0.0015 17.7 0.1 0.0015 17.7 0.1 1.9 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) HrpB7 PF09486.5 ESA17040.1 - 0.016 15.0 0.2 0.021 14.7 0.1 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) FlaC_arch PF05377.6 ESA17040.1 - 0.032 14.1 0.9 0.032 14.1 0.6 1.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Phage_lysis PF03245.8 ESA17040.1 - 0.17 11.8 3.0 0.073 13.0 0.4 1.6 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein SPX PF03105.14 ESA17040.1 - 0.45 10.2 10.0 0.63 9.7 7.0 1.2 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.4 ESA17040.1 - 0.63 8.2 9.0 0.15 10.2 4.2 1.4 1 1 0 1 1 1 0 Transmembrane protein Fib_alpha PF08702.5 ESA17040.1 - 1.6 8.8 7.9 0.89 9.6 3.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3039 PF11238.3 ESA17042.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) Tom22 PF04281.8 ESA17042.1 - 0.13 11.7 0.3 0.2 11.1 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Pkinase PF00069.20 ESA17043.1 - 9.6e-06 24.9 0.0 1.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DDE_Tnp_ISAZ013 PF07592.6 ESA17044.1 - 0.00014 20.6 0.0 0.0033 16.2 0.0 2.2 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain zf-C2H2_jaz PF12171.3 ESA17044.1 - 0.17 12.0 2.5 0.38 10.9 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding UPF0122 PF04297.9 ESA17044.1 - 2.7 8.0 11.5 0.047 13.6 2.8 1.9 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like Pkinase_Tyr PF07714.12 ESA17045.1 - 0.011 14.8 0.0 0.012 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF872 PF05915.7 ESA17047.1 - 0.012 15.5 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DnaA_N PF11638.3 ESA17047.1 - 0.072 12.6 0.2 0.079 12.5 0.1 1.1 1 0 0 1 1 1 0 DnaA N-terminal domain PUB PF09409.5 ESA17047.1 - 0.091 12.5 0.3 0.11 12.2 0.2 1.1 1 0 0 1 1 1 0 PUB domain TRP_N PF14558.1 ESA17047.1 - 0.12 12.4 0.3 0.12 12.4 0.2 1.0 1 0 0 1 1 1 0 ML-like domain Planc_extracel PF07595.7 ESA17048.1 - 0.092 12.4 5.0 0.14 11.9 3.4 1.2 1 0 0 1 1 1 0 Planctomycete extracellular UDPGT PF00201.13 ESA17049.1 - 0.039 12.4 0.1 0.065 11.7 0.1 1.4 1 1 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Cation_ATPase_N PF00690.21 ESA17050.1 - 2.9e-17 61.8 0.0 3.5e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Exonuc_VII_L PF02601.10 ESA17051.1 - 0.12 11.5 0.3 0.11 11.6 0.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4419 PF14388.1 ESA17052.1 - 7.1e-71 238.8 2.4 7.9e-71 238.7 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Pkinase_Tyr PF07714.12 ESA17053.1 - 3.9e-12 45.7 0.0 5.2e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17053.1 - 5.5e-11 42.1 0.0 9.1e-11 41.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain VirionAssem_T7 PF11653.3 ESA17054.1 - 0.088 13.5 2.8 0.17 12.6 1.9 1.4 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein UCH PF00443.24 ESA17055.1 - 2.5e-58 197.2 0.7 3.2e-58 196.9 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA17055.1 - 3.5e-19 69.3 4.3 6.7e-19 68.4 3.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 ESA17055.1 - 5.8e-13 48.0 0.5 3.8e-12 45.4 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.3 ESA17055.1 - 0.00047 19.7 0.3 0.0015 18.2 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA17055.1 - 0.045 14.0 0.2 0.045 14.0 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain DUF4472 PF14739.1 ESA17055.1 - 0.058 13.8 2.1 0.095 13.1 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Fib_alpha PF08702.5 ESA17055.1 - 0.13 12.4 4.0 1 9.4 0.1 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Ribosomal_60s PF00428.14 ESA17056.1 - 5.4e-25 87.5 4.6 6.4e-25 87.3 3.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Chorion_3 PF05387.6 ESA17056.1 - 0.17 11.2 1.8 0.2 11.0 1.2 1.1 1 0 0 1 1 1 0 Chorion family 3 PPR PF01535.15 ESA17057.1 - 1.1e-11 43.9 6.6 0.0069 16.2 0.0 6.4 6 0 0 6 6 6 3 PPR repeat PPR_2 PF13041.1 ESA17057.1 - 1.4e-10 40.9 14.6 0.00012 21.9 0.0 6.4 6 1 2 8 8 8 4 PPR repeat family PPR_3 PF13812.1 ESA17057.1 - 4e-09 36.0 0.2 0.45 10.9 0.0 6.3 7 0 0 7 7 7 2 Pentatricopeptide repeat domain DUF309 PF03745.9 ESA17057.1 - 0.0013 18.1 0.0 4.1 6.9 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF309) TPR_8 PF13181.1 ESA17057.1 - 0.017 14.8 0.5 3.3 7.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_1 PF12854.2 ESA17057.1 - 0.068 12.6 0.0 0.068 12.6 0.0 3.3 4 0 0 4 4 4 0 PPR repeat Prefoldin_2 PF01920.15 ESA17058.1 - 2.8e-23 81.7 19.0 3.5e-23 81.3 13.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.1 ESA17058.1 - 0.00064 19.4 8.0 0.00067 19.3 5.1 1.4 1 1 0 1 1 1 1 Prefoldin subunit DUF2117 PF09890.4 ESA17058.1 - 0.024 13.8 1.7 0.025 13.7 1.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) IncA PF04156.9 ESA17058.1 - 0.025 14.2 19.0 0.52 9.8 4.8 2.0 1 1 0 2 2 2 0 IncA protein DUF848 PF05852.6 ESA17058.1 - 0.037 13.8 11.2 0.028 14.2 1.7 2.1 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1192 PF06698.6 ESA17058.1 - 0.075 12.8 3.6 1 9.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF1640 PF07798.6 ESA17058.1 - 0.13 12.3 12.3 0.084 12.9 5.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Fzo_mitofusin PF04799.8 ESA17058.1 - 0.15 11.4 11.0 0.099 12.0 1.0 2.1 2 0 0 2 2 2 0 fzo-like conserved region TPR_MLP1_2 PF07926.7 ESA17058.1 - 0.19 11.4 16.0 0.17 11.5 4.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein COG5 PF10392.4 ESA17058.1 - 0.19 11.6 11.1 1.3 8.9 0.4 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF972 PF06156.8 ESA17058.1 - 0.26 11.6 13.4 1.5 9.2 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 ESA17058.1 - 0.26 12.0 11.3 2.2 9.0 0.6 2.1 2 0 0 2 2 2 0 Occludin homology domain FlxA PF14282.1 ESA17058.1 - 0.31 11.0 20.2 0.069 13.0 6.1 2.2 2 0 0 2 2 2 0 FlxA-like protein CENP-F_leu_zip PF10473.4 ESA17058.1 - 0.31 10.8 15.7 0.71 9.7 2.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.12 ESA17058.1 - 0.4 10.3 13.5 2.4 7.8 9.3 2.1 1 1 0 1 1 1 0 Prefoldin subunit DUF1664 PF07889.7 ESA17058.1 - 0.41 10.4 10.8 0.9 9.3 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) She9_MDM33 PF05546.6 ESA17058.1 - 0.42 10.1 12.6 0.53 9.8 3.0 2.0 1 1 1 2 2 2 0 She9 / Mdm33 family YgaB PF14182.1 ESA17058.1 - 0.47 10.7 14.9 0.061 13.5 4.1 2.3 2 0 0 2 2 2 0 YgaB-like protein EzrA PF06160.7 ESA17058.1 - 0.48 8.5 16.0 0.037 12.2 4.5 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Macoilin PF09726.4 ESA17058.1 - 0.49 8.6 11.8 0.62 8.2 8.2 1.1 1 0 0 1 1 1 0 Transmembrane protein MitMem_reg PF13012.1 ESA17058.1 - 0.5 10.4 9.6 0.23 11.5 2.2 2.1 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function ERM PF00769.14 ESA17058.1 - 1 8.8 14.9 1.5 8.3 10.3 1.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Rootletin PF15035.1 ESA17058.1 - 1.4 8.8 12.3 2.5 8.0 1.1 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.6 ESA17058.1 - 1.9 7.1 16.0 2.3 6.8 11.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Vac_Fusion PF02346.11 ESA17058.1 - 2 7.9 5.8 5.7 6.4 0.0 3.1 3 1 0 3 3 2 0 Chordopoxvirus fusion protein TBPIP PF07106.8 ESA17058.1 - 2.1 7.8 18.6 2.9 7.4 2.4 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF948 PF06103.6 ESA17058.1 - 2.2 8.1 6.7 1.6 8.6 1.0 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.2 ESA17058.1 - 2.5 7.9 18.2 2.5 7.9 2.4 2.1 2 0 0 2 2 2 0 Tropomyosin like ATG16 PF08614.6 ESA17058.1 - 2.6 7.8 14.4 13 5.5 10.0 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3847 PF12958.2 ESA17058.1 - 2.7 7.8 15.0 0.99 9.2 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) NPV_P10 PF05531.7 ESA17058.1 - 3.7 7.8 10.3 4.2 7.6 2.0 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.4 ESA17058.1 - 5.2 6.1 14.5 55 2.8 9.9 2.0 1 1 0 1 1 1 0 Clusterin-associated protein-1 DMPK_coil PF08826.5 ESA17058.1 - 6 6.8 17.3 1.3 8.9 2.2 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like Seryl_tRNA_N PF02403.17 ESA17058.1 - 7.6 6.6 14.1 32 4.5 2.0 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3166 PF11365.3 ESA17058.1 - 7.6 7.0 8.3 0.87 10.0 1.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3166) Fib_alpha PF08702.5 ESA17058.1 - 9.7 6.3 14.7 2.7 8.0 4.1 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Robl_LC7 PF03259.12 ESA17059.1 - 1.3e-16 59.9 0.0 1.5e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain DUF2680 PF10925.3 ESA17059.1 - 0.06 13.2 0.1 1.2 9.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2680) Cauli_DNA-bind PF03310.8 ESA17059.1 - 0.093 12.5 0.1 0.095 12.5 0.1 1.1 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Claudin_2 PF13903.1 ESA17060.1 - 0.0045 16.6 0.5 0.0051 16.5 0.4 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.4 ESA17060.1 - 0.06 11.9 0.6 0.065 11.8 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Methyltransf_23 PF13489.1 ESA17061.1 - 1.5e-12 47.5 0.0 3.6e-12 46.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA17061.1 - 1.2e-10 41.7 0.0 2e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA17061.1 - 1.8e-07 30.8 0.0 9.2e-07 28.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17061.1 - 1.4e-06 28.5 0.0 3e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA17061.1 - 5.2e-05 23.6 0.0 0.00023 21.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA17061.1 - 0.00015 22.3 0.0 0.001 19.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA17061.1 - 0.00021 20.5 0.0 0.00043 19.4 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA17061.1 - 0.0029 16.6 0.0 0.0056 15.7 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase MetW PF07021.7 ESA17061.1 - 0.0034 16.7 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.15 ESA17061.1 - 0.028 13.4 0.0 0.043 12.8 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.10 ESA17061.1 - 0.055 13.0 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_26 PF13659.1 ESA17061.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Pkinase_Tyr PF07714.12 ESA17062.1 - 7.9e-05 21.8 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17062.1 - 0.0038 16.4 0.0 0.0077 15.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain DUF1542 PF07564.6 ESA17064.1 - 0.0043 17.0 1.2 0.0055 16.7 0.2 1.6 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) Scaffolding_pro PF11418.3 ESA17064.1 - 0.01 16.1 0.3 0.014 15.6 0.2 1.3 1 1 0 1 1 1 0 Phi29 scaffolding protein Baculo_VP91_N PF08475.5 ESA17064.1 - 0.016 14.5 0.4 0.018 14.4 0.3 1.1 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal DUF148 PF02520.12 ESA17064.1 - 0.049 13.4 0.6 0.081 12.7 0.4 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 KapB PF08810.5 ESA17064.1 - 0.052 13.6 0.2 0.056 13.5 0.1 1.1 1 0 0 1 1 1 0 Kinase associated protein B DUF1033 PF06279.6 ESA17064.1 - 0.13 12.1 1.3 0.17 11.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) DUF3896 PF13035.1 ESA17064.1 - 0.33 11.0 2.3 0.94 9.5 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3896) P34-Arc PF04045.9 ESA17065.1 - 1.2e-16 60.7 2.2 8.1e-09 35.1 0.6 2.1 1 1 1 2 2 2 2 Arp2/3 complex, 34 kD subunit p34-Arc Pkinase_Tyr PF07714.12 ESA17066.1 - 2.3e-36 125.1 0.0 5.7e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17066.1 - 1.9e-33 115.7 1.2 2.8e-33 115.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA17066.1 - 3.1e-10 40.3 5.2 0.00047 20.7 0.0 3.8 3 0 0 3 3 3 2 Sel1 repeat Herpes_UL36 PF03586.8 ESA17066.1 - 0.0054 15.8 1.3 0.01 14.9 0.9 1.4 1 0 0 1 1 1 1 Herpesvirus UL36 tegument protein DUF4419 PF14388.1 ESA17067.1 - 5.6e-71 239.1 0.4 6.2e-71 239.0 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Aldo_ket_red PF00248.16 ESA17069.1 - 4.1e-66 222.7 0.0 4.7e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA17071.1 - 5.9e-35 120.4 0.0 6.6e-35 120.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AhpC-TSA_2 PF13911.1 ESA17072.1 - 0.055 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Peptidase_C54 PF03416.14 ESA17074.1 - 1.1e-19 70.6 0.0 1.7e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 DUF1294 PF06961.8 ESA17075.1 - 1.1e-17 63.7 0.6 2.1e-17 62.8 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1294) TauE PF01925.14 ESA17075.1 - 0.0037 16.7 0.9 0.0051 16.2 0.6 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE DUF3329 PF11808.3 ESA17075.1 - 0.014 15.4 0.7 0.014 15.4 0.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3329) HemY_N PF07219.8 ESA17075.1 - 0.4 10.2 3.4 4.6 6.8 0.3 2.6 2 1 0 2 2 2 0 HemY protein N-terminus Pkinase PF00069.20 ESA17076.1 - 5.6e-16 58.4 0.0 6.2e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17076.1 - 2.4e-15 56.3 0.0 2.6e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PsbU PF06514.6 ESA17076.1 - 0.024 14.4 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) E3_UbLigase_EDD PF11547.3 ESA17077.1 - 0.054 12.9 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD DUF4446 PF14584.1 ESA17078.1 - 0.16 11.7 0.0 0.16 11.7 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF4446) IBN_N PF03810.14 ESA17078.1 - 2.7 7.9 6.1 43 4.1 0.1 3.4 3 0 0 3 3 3 0 Importin-beta N-terminal domain RCR PF12273.3 ESA17078.1 - 3.5 8.1 0.0 3.5 8.1 0.0 3.7 4 1 1 5 5 5 0 Chitin synthesis regulation, resistance to Congo red DUF3470 PF11953.3 ESA17079.1 - 0.008 15.7 0.1 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3470) DUF3974 PF13120.1 ESA17079.1 - 0.066 13.0 4.5 0.33 10.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3974) Gram_pos_anchor PF00746.16 ESA17080.1 - 0.029 14.1 4.3 1.2 8.9 0.6 2.3 2 0 0 2 2 2 0 Gram positive anchor DUF4366 PF14283.1 ESA17080.1 - 0.5 9.7 5.5 0.15 11.5 0.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Metallophos PF00149.23 ESA17085.1 - 5e-15 55.4 2.9 9e-15 54.6 2.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PEX11 PF05648.9 ESA17086.1 - 4.4e-27 94.7 0.1 5.3e-27 94.5 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Pro_dh PF01619.13 ESA17087.1 - 4.8e-60 203.1 0.1 7.8e-60 202.4 0.1 1.4 1 0 0 1 1 1 1 Proline dehydrogenase EF-hand_7 PF13499.1 ESA17087.1 - 3.7e-08 33.3 9.5 6.7e-08 32.5 3.7 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 ESA17087.1 - 2.1e-06 26.6 11.6 0.00025 20.1 0.2 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 ESA17087.1 - 5.6e-05 22.6 11.8 0.0064 16.2 0.2 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 ESA17087.1 - 0.00023 20.7 3.5 0.19 11.3 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESA17087.1 - 0.00023 21.1 0.4 0.00023 21.1 0.3 2.9 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.1 ESA17087.1 - 0.0062 15.8 0.5 0.0062 15.8 0.4 2.7 2 0 0 2 2 2 1 EF hand AP_endonuc_2 PF01261.19 ESA17087.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Symplekin_C PF12295.3 ESA17087.1 - 0.26 11.2 3.0 4.3 7.2 0.1 2.5 2 0 0 2 2 2 0 Symplekin tight junction protein C terminal Alpha-amylase PF00128.19 ESA17087.1 - 0.34 10.2 4.1 0.48 9.7 0.4 2.4 3 0 0 3 3 3 0 Alpha amylase, catalytic domain Radical_SAM PF04055.16 ESA17089.1 - 3.1e-27 95.7 0.2 6.5e-27 94.7 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Wyosine_form PF08608.7 ESA17089.1 - 1.8e-23 82.3 0.1 6.7e-23 80.5 0.0 2.0 2 0 0 2 2 2 1 Wyosine base formation Flavodoxin_1 PF00258.20 ESA17089.1 - 5.7e-18 65.2 0.1 1.2e-17 64.2 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin Peptidase_C65 PF10275.4 ESA17089.1 - 0.031 13.6 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase C65 Otubain F-box-like PF12937.2 ESA17090.1 - 1.8e-05 24.3 1.2 1.8e-05 24.3 0.8 2.3 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.2 ESA17090.1 - 0.00095 18.7 1.3 0.63 9.7 0.0 3.9 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA17090.1 - 0.0075 15.9 4.7 1.3 8.8 0.3 3.5 3 0 0 3 3 3 2 Leucine rich repeat DUF4203 PF13886.1 ESA17092.1 - 1.1e-16 60.9 24.8 2.1e-16 60.0 17.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF3040 PF11239.3 ESA17092.1 - 0.13 12.2 0.7 0.44 10.6 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) VHS PF00790.14 ESA17093.1 - 3.9e-40 136.7 3.9 1.2e-38 131.9 0.0 3.3 3 0 0 3 3 3 1 VHS domain FYVE PF01363.16 ESA17093.1 - 1.5e-17 63.1 11.0 3e-17 62.2 7.6 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 ESA17093.1 - 7.2e-08 32.3 4.9 7.2e-08 32.3 3.4 2.6 2 0 0 2 2 2 1 FYVE-type zinc finger UIM PF02809.15 ESA17093.1 - 8.7e-05 21.7 10.1 0.021 14.3 0.5 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif IBR PF01485.16 ESA17093.1 - 0.0042 16.9 3.3 0.0092 15.8 2.3 1.5 1 0 0 1 1 1 1 IBR domain Hrs_helical PF12210.3 ESA17093.1 - 0.14 12.4 3.0 0.095 12.9 0.7 1.7 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF4375 PF14300.1 ESA17093.1 - 0.36 10.8 0.0 0.36 10.8 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) S4 PF01479.20 ESA17095.1 - 8.1e-06 25.1 0.0 1.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 S4 domain TB2_DP1_HVA22 PF03134.14 ESA17096.1 - 1.7e-21 75.7 3.2 3.5e-21 74.7 2.2 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Pkinase PF00069.20 ESA17097.1 - 3.1e-38 131.4 0.0 4e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17097.1 - 3.9e-37 127.7 0.0 4.7e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA17097.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA17098.1 - 1.9e-32 112.3 0.8 1.4e-23 83.3 0.1 7.7 9 0 0 9 9 9 2 Protein tyrosine kinase BCS1_N PF08740.6 ESA17098.1 - 6.4e-13 48.7 6.4 0.15 11.6 0.0 7.9 8 0 0 8 8 8 5 BCS1 N terminal Tubulin_C PF03953.12 ESA17098.1 - 0.0023 17.9 6.8 2.5 8.1 0.0 5.9 5 2 1 6 6 6 1 Tubulin C-terminal domain Rio2_N PF09202.6 ESA17098.1 - 0.026 14.5 0.0 1.5e+02 2.5 0.0 5.3 6 0 0 6 6 6 0 Rio2, N-terminal DUF2179 PF10035.4 ESA17098.1 - 0.035 13.7 0.1 6.3 6.4 0.0 3.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2179) vATP-synt_E PF01991.13 ESA17098.1 - 0.051 12.8 4.2 12 5.0 0.0 4.2 4 0 0 4 4 4 0 ATP synthase (E/31 kDa) subunit CENP-X PF09415.5 ESA17098.1 - 0.15 11.8 0.3 1e+02 2.7 0.0 4.1 4 0 0 4 4 4 0 CENP-S associating Centromere protein X Pkinase_Tyr PF07714.12 ESA17100.1 - 7.6e-37 126.7 0.0 9.2e-37 126.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17100.1 - 1.8e-36 125.6 0.2 2.2e-36 125.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA17100.1 - 0.0002 20.4 0.0 0.00026 20.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA17100.1 - 0.001 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA17100.1 - 0.0031 16.8 0.3 0.0049 16.2 0.2 1.4 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA17100.1 - 0.0037 16.6 0.1 0.076 12.3 0.0 2.0 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL APH PF01636.18 ESA17100.1 - 0.016 14.9 0.1 4.6 6.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family TrfA PF07042.6 ESA17100.1 - 0.047 12.5 0.1 0.062 12.1 0.1 1.2 1 0 0 1 1 1 0 TrfA protein Sel1 PF08238.7 ESA17101.1 - 8.6e-49 162.9 6.9 2.8e-09 37.3 0.0 6.2 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA17101.1 - 0.006 16.9 3.3 27 5.5 0.0 4.7 4 1 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 ESA17101.1 - 4.5 7.2 6.8 7.7 6.4 0.3 3.6 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain Aldo_ket_red PF00248.16 ESA17104.1 - 2.7e-16 59.2 0.0 4.6e-16 58.4 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA17105.1 - 6.8e-29 100.5 0.0 7.9e-29 100.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family P22_AR_C PF10548.4 ESA17105.1 - 0.051 13.4 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 P22AR C-terminal domain WD40 PF00400.27 ESA17106.1 - 1e-11 44.2 2.5 0.0082 15.9 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat PQQ_2 PF13360.1 ESA17106.1 - 0.001 18.5 0.0 0.021 14.2 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain Coatomer_WDAD PF04053.9 ESA17106.1 - 0.001 17.9 1.8 0.21 10.3 0.2 2.4 2 1 0 2 2 2 2 Coatomer WD associated region BBS2_Mid PF14783.1 ESA17106.1 - 0.0094 15.7 0.1 0.42 10.3 0.0 3.0 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Chordopox_L2 PF05803.7 ESA17108.1 - 0.21 11.2 5.5 0.29 10.7 0.9 2.3 1 1 1 2 2 2 0 Chordopoxvirus L2 protein FAT PF02259.18 ESA17110.1 - 7.8e-63 212.5 6.8 2.4e-62 210.9 4.7 1.9 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.22 ESA17110.1 - 8.3e-28 97.4 3.4 9e-28 97.3 0.8 2.4 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 ESA17110.1 - 0.0022 17.3 1.0 0.0062 15.9 0.7 1.8 1 0 0 1 1 1 1 FATC domain TPR_2 PF07719.12 ESA17110.1 - 0.021 14.7 0.0 0.19 11.6 0.0 2.8 1 0 0 1 1 1 0 Tetratricopeptide repeat HEAT_2 PF13646.1 ESA17110.1 - 0.039 14.2 1.8 0.43 10.9 0.0 3.7 4 0 0 4 4 4 0 HEAT repeats DUF92 PF01940.11 ESA17110.1 - 0.36 9.9 0.0 0.67 9.0 0.0 1.3 1 0 0 1 1 1 0 Integral membrane protein DUF92 MBOAT PF03062.14 ESA17111.1 - 1.7e-27 96.4 20.2 3.7e-27 95.3 14.0 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 ESA17111.1 - 1.5e-05 24.9 1.7 5.8e-05 23.0 1.2 2.1 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Nucleos_tra2_N PF01773.15 ESA17111.1 - 0.16 12.3 3.8 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter N-terminus MRP_L53 PF10780.4 ESA17114.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 CCDC155 PF14662.1 ESA17115.1 - 0.0034 17.0 6.8 0.0034 17.0 4.7 2.0 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 IncA PF04156.9 ESA17115.1 - 0.0047 16.5 5.7 0.0076 15.8 4.0 1.4 1 0 0 1 1 1 1 IncA protein DUF4075 PF13294.1 ESA17115.1 - 0.017 15.1 1.5 0.042 13.8 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4075) GAS PF13851.1 ESA17115.1 - 0.027 13.6 18.4 0.018 14.2 5.9 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding HAUS-augmin3 PF14932.1 ESA17115.1 - 0.12 11.5 10.3 0.02 14.0 4.3 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Mit_KHE1 PF10173.4 ESA17115.1 - 0.14 12.0 2.9 0.19 11.5 0.2 2.0 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Filament PF00038.16 ESA17115.1 - 0.15 11.5 16.0 0.22 10.9 0.2 3.4 1 1 2 3 3 3 0 Intermediate filament protein DUF812 PF05667.6 ESA17115.1 - 0.15 10.5 14.1 0.21 10.0 9.7 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF812) GldM_N PF12081.3 ESA17115.1 - 0.16 11.5 11.9 0.035 13.6 5.5 2.0 2 1 0 2 2 2 0 GldM N-terminal domain PilJ PF13675.1 ESA17115.1 - 0.21 11.9 3.1 0.23 11.7 0.3 2.2 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term BLOC1_2 PF10046.4 ESA17115.1 - 0.21 11.7 9.2 0.062 13.4 3.5 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ACCA PF03255.9 ESA17115.1 - 0.32 10.5 5.8 0.084 12.4 1.6 1.9 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF3450 PF11932.3 ESA17115.1 - 0.44 9.7 9.6 0.04 13.1 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4047 PF13256.1 ESA17115.1 - 0.46 10.4 8.0 0.13 12.2 2.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DUF445 PF04286.7 ESA17115.1 - 0.49 9.8 10.7 0.25 10.8 5.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF445) DUF883 PF05957.8 ESA17115.1 - 0.54 10.6 5.8 1.7 9.1 0.5 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) AAA_23 PF13476.1 ESA17115.1 - 0.55 10.5 17.7 0.77 10.0 12.3 1.3 1 0 0 1 1 1 0 AAA domain Mnd1 PF03962.10 ESA17115.1 - 1.4 8.5 12.2 0.033 13.8 2.6 2.2 2 1 0 2 2 2 0 Mnd1 family Syntaxin-6_N PF09177.6 ESA17115.1 - 1.6 9.1 12.6 0.1 12.9 3.6 2.7 2 2 1 3 3 3 0 Syntaxin 6, N-terminal Atg14 PF10186.4 ESA17115.1 - 2.1 7.2 18.8 1.4 7.7 0.4 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF724 PF05266.9 ESA17115.1 - 2.5 7.6 10.4 0.26 10.8 4.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Syntaxin PF00804.20 ESA17115.1 - 5 7.3 18.7 0.054 13.6 5.5 2.8 2 2 0 2 2 2 0 Syntaxin DUF1664 PF07889.7 ESA17115.1 - 5.8 6.7 7.2 1.5 8.6 2.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TSC22 PF01166.13 ESA17115.1 - 7.9 6.5 10.1 3 7.8 3.6 2.6 2 1 0 2 2 2 0 TSC-22/dip/bun family DUF342 PF03961.8 ESA17115.1 - 9.5 4.5 15.3 2.8 6.2 8.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF342) BEX PF04538.7 ESA17115.1 - 9.8 6.4 9.4 28 4.9 6.4 2.1 1 1 0 1 1 1 0 Brain expressed X-linked like family Cyt-b5 PF00173.23 ESA17117.1 - 2e-20 72.3 0.0 3.3e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2895 PF11444.3 ESA17117.1 - 0.0086 15.3 0.2 0.36 9.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2895) GFO_IDH_MocA PF01408.17 ESA17118.1 - 1.9e-21 76.7 0.0 4e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 ESA17118.1 - 3.7e-08 33.1 0.0 1.3e-06 28.2 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain TauD PF02668.11 ESA17120.1 - 0.044 13.4 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family KTI12 PF08433.5 ESA17120.1 - 0.086 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Peptidase_S8 PF00082.17 ESA17122.1 - 1.3e-33 116.3 1.8 1.5e-33 116.1 1.3 1.0 1 0 0 1 1 1 1 Subtilase family Bcl-2 PF00452.14 ESA17122.1 - 0.15 12.1 0.3 1.7 8.7 0.2 2.2 1 1 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Exonuc_V_gamma PF04257.9 ESA17125.1 - 0.0011 17.1 0.5 0.0014 16.7 0.2 1.2 1 1 0 1 1 1 1 Exodeoxyribonuclease V, gamma subunit Rapamycin_bind PF08771.6 ESA17125.1 - 0.008 16.2 0.7 0.12 12.4 0.1 2.2 2 0 0 2 2 2 1 Rapamycin binding domain DUF4108 PF13390.1 ESA17125.1 - 0.12 12.0 6.8 0.18 11.5 4.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4108) CTD_bind PF04818.8 ESA17125.1 - 0.75 10.0 3.7 17 5.7 0.1 2.8 1 1 2 3 3 3 0 RNA polymerase II-binding domain. MFS_1 PF07690.11 ESA17128.1 - 8e-21 74.1 28.0 2.1e-13 49.7 7.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.8 ESA17128.1 - 3.5e-18 65.7 7.8 3.5e-18 65.7 5.4 2.1 2 0 0 2 2 2 1 Nodulin-like DUF498 PF04430.9 ESA17129.1 - 2.5e-26 91.3 0.0 3.3e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Latrophilin PF02354.11 ESA17129.1 - 0.11 11.1 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region DUF1682 PF07946.9 ESA17130.1 - 5.5e-85 285.0 7.9 6.7e-85 284.7 5.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF4355 PF14265.1 ESA17130.1 - 0.15 11.9 28.5 0.31 10.9 19.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) RF-1 PF00472.15 ESA17130.1 - 0.17 11.6 8.2 0.36 10.6 5.7 1.5 1 0 0 1 1 1 0 RF-1 domain Desulfoferrod_N PF06397.7 ESA17131.1 - 0.26 10.6 1.2 20 4.6 0.1 2.4 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain DDE_3 PF13358.1 ESA17133.1 - 2.7e-06 27.2 0.3 1.8e-05 24.5 0.2 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF3414 PF11894.3 ESA17134.1 - 0.00079 16.4 2.1 0.089 9.6 0.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3414) Bunya_nucleocap PF00952.12 ESA17134.1 - 0.0015 18.5 2.0 0.08 12.9 0.1 2.1 2 0 0 2 2 2 2 Bunyavirus nucleocapsid (N) protein Vsr PF03852.10 ESA17135.1 - 0.017 14.7 0.0 0.041 13.5 0.0 1.6 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr F-box-like PF12937.2 ESA17139.1 - 1.4e-06 27.9 0.0 2.8e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA17139.1 - 0.00059 19.4 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain Viral_P18 PF04521.8 ESA17139.1 - 0.043 13.2 2.9 0.066 12.6 2.0 1.4 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein F-box-like PF12937.2 ESA17140.1 - 0.0036 17.0 3.6 0.0073 16.0 0.8 2.8 3 0 0 3 3 3 1 F-box-like LRR_6 PF13516.1 ESA17140.1 - 1.7 8.9 11.6 0.73 10.0 1.9 4.8 5 0 0 5 5 5 0 Leucine Rich repeat Tetradecapep PF08187.6 ESA17142.1 - 0.28 11.1 1.0 0.64 9.9 0.7 1.6 1 0 0 1 1 1 0 Myoactive tetradecapeptides family TLD PF07534.11 ESA17143.1 - 2.8e-34 118.0 2.4 3.8e-34 117.6 0.8 1.9 2 0 0 2 2 2 1 TLD Dimer_Tnp_hAT PF05699.9 ESA17145.1 - 1.2e-21 76.1 0.4 2.3e-21 75.2 0.1 1.6 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region SMC_N PF02463.14 ESA17151.1 - 2.3e-10 40.0 0.1 2.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 ESA17151.1 - 0.00064 19.5 0.0 0.0018 18.1 0.0 1.8 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.1 ESA17151.1 - 0.0086 16.0 0.1 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESA17151.1 - 0.026 14.7 0.0 0.042 14.1 0.0 1.4 1 1 0 1 1 1 0 ABC transporter PPDK_N PF01326.14 ESA17151.1 - 0.11 11.5 0.1 0.14 11.1 0.1 1.1 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain SMC_hinge PF06470.8 ESA17152.1 - 0.088 12.7 0.0 0.32 10.9 0.0 2.0 1 1 0 1 1 1 0 SMC proteins Flexible Hinge Domain IncA PF04156.9 ESA17152.1 - 0.64 9.5 4.3 1.1 8.8 3.0 1.4 1 0 0 1 1 1 0 IncA protein Cgr1 PF03879.9 ESA17152.1 - 0.69 10.1 2.5 0.46 10.6 0.5 1.6 2 0 0 2 2 2 0 Cgr1 family Cortex-I_coil PF09304.5 ESA17152.1 - 0.84 9.7 4.4 0.71 9.9 1.3 1.9 2 0 0 2 2 2 0 Cortexillin I, coiled coil Med9 PF07544.8 ESA17152.1 - 0.89 9.3 4.3 1.8 8.3 3.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 AAA_23 PF13476.1 ESA17153.1 - 2.7e-16 60.5 19.4 7.3e-15 55.8 13.4 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 ESA17153.1 - 6.8e-16 58.1 2.4 8.5e-16 57.8 1.6 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 ESA17153.1 - 2.7e-05 23.5 0.0 4.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 ESA17153.1 - 2.7e-05 23.3 10.0 0.00022 20.3 6.6 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_13 PF13166.1 ESA17153.1 - 0.00042 18.9 16.0 0.042 12.3 6.3 2.1 1 1 0 2 2 2 2 AAA domain AAA_21 PF13304.1 ESA17153.1 - 0.0018 18.2 5.4 0.0057 16.6 3.7 1.9 1 1 0 1 1 1 1 AAA domain Phage_int_SAM_1 PF02899.12 ESA17153.1 - 0.026 14.6 0.4 0.096 12.8 0.0 2.1 2 1 1 3 3 3 0 Phage integrase, N-terminal SAM-like domain Myosin_N PF02736.14 ESA17153.1 - 0.057 13.0 0.5 0.12 12.0 0.3 1.6 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.1 ESA17153.1 - 0.38 10.7 2.9 2.4 8.1 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Laminin_II PF06009.7 ESA17153.1 - 0.42 10.3 5.7 1.9 8.2 2.9 2.4 1 1 1 2 2 2 0 Laminin Domain II DUF4061 PF13270.1 ESA17153.1 - 1 9.4 5.8 3.1 7.9 4.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) ABC_tran PF00005.22 ESA17153.1 - 1.5 9.1 9.6 0.17 12.1 1.6 2.3 1 1 0 2 2 2 0 ABC transporter Mnd1 PF03962.10 ESA17153.1 - 1.6 8.3 12.4 2.3 7.8 6.3 2.4 2 1 0 2 2 2 0 Mnd1 family FliJ PF02050.11 ESA17154.1 - 0.0023 17.9 0.8 0.0033 17.4 0.5 1.3 1 0 0 1 1 1 1 Flagellar FliJ protein Pex19 PF04614.7 ESA17154.1 - 0.035 13.7 4.4 0.039 13.5 3.0 1.0 1 0 0 1 1 1 0 Pex19 protein family Aldedh PF00171.17 ESA17154.1 - 0.12 10.7 0.4 0.14 10.4 0.3 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Pkinase_Tyr PF07714.12 ESA17155.1 - 1.2e-44 152.3 0.0 1.6e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17155.1 - 4.6e-37 127.5 0.0 6.7e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA17155.1 - 0.0054 16.4 1.1 0.011 15.5 0.8 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA17155.1 - 0.075 12.3 1.2 0.2 10.9 0.2 2.0 1 1 1 2 2 2 0 RIO1 family Pkinase_Tyr PF07714.12 ESA17156.1 - 3.4e-30 105.0 0.2 6.7e-30 104.0 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17156.1 - 7e-27 94.2 0.3 7e-27 94.2 0.2 1.5 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA17156.1 - 0.038 14.6 0.4 1.2 9.8 0.1 3.2 3 0 0 3 3 3 0 Sel1 repeat Trypsin PF00089.21 ESA17159.1 - 0.0048 16.4 0.1 0.037 13.6 0.0 2.0 2 0 0 2 2 2 1 Trypsin Trypsin_2 PF13365.1 ESA17159.1 - 0.021 14.8 0.0 0.11 12.5 0.0 2.0 1 1 0 1 1 1 0 Trypsin-like peptidase domain SpoVS PF04232.7 ESA17159.1 - 0.057 13.0 0.1 0.093 12.3 0.1 1.3 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) FAD_binding_4 PF01565.18 ESA17160.1 - 1.2e-28 99.2 3.0 1.8e-28 98.7 2.1 1.2 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 ESA17160.1 - 1.7e-07 30.9 2.0 1.7e-07 30.9 1.4 2.2 2 0 0 2 2 2 1 Berberine and berberine like p450 PF00067.17 ESA17161.1 - 2e-88 296.9 0.0 2.4e-88 296.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TM1586_NiRdase PF14512.1 ESA17162.1 - 0.12 11.5 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Putative TM nitroreductase Sel1 PF08238.7 ESA17163.1 - 7.4e-26 90.0 7.3 2.3e-09 37.6 0.0 3.1 3 0 0 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA17163.1 - 0.0003 20.6 5.8 1.6 8.6 0.0 3.8 2 1 2 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA17163.1 - 0.0046 17.3 1.4 0.44 11.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17163.1 - 0.093 12.5 2.2 4.2 7.4 0.2 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17163.1 - 0.34 10.5 8.5 1.1 8.9 1.5 2.9 1 1 1 2 2 2 0 TPR repeat TPR_12 PF13424.1 ESA17163.1 - 0.36 10.7 5.3 27 4.7 1.8 3.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA17163.1 - 0.36 10.6 4.4 16 5.4 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17163.1 - 1.4 8.8 6.7 71 3.5 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA17163.1 - 1.4 9.0 10.7 12 6.1 0.3 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA17163.1 - 1.7 8.4 14.1 7 6.4 0.2 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA17164.1 - 2.3e-09 37.5 1.1 1.8e-07 31.5 0.2 2.2 2 0 0 2 2 2 2 Sel1 repeat YxiJ PF14176.1 ESA17166.1 - 0.0051 16.9 0.0 0.0059 16.7 0.0 1.0 1 0 0 1 1 1 1 YxiJ-like protein tRNA-synt_2b PF00587.20 ESA17167.1 - 4.6e-45 153.2 0.3 9e-45 152.3 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA17167.1 - 9.3e-16 57.5 0.3 2.3e-15 56.3 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 ESA17167.1 - 4.9e-14 51.9 0.0 1.1e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 ESA17167.1 - 3.8e-13 49.0 0.0 1.6e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 TGS domain PGM_PMM_I PF02878.11 ESA17168.1 - 3e-38 130.4 0.0 6.1e-38 129.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 ESA17168.1 - 8.5e-25 87.0 0.0 1.7e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 ESA17168.1 - 3.6e-13 49.5 0.3 2e-12 47.1 0.2 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 ESA17168.1 - 5.3e-07 29.5 0.0 2.8e-06 27.2 0.0 2.2 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Herpes_UL36 PF03586.8 ESA17168.1 - 0.055 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein ubiquitin PF00240.18 ESA17169.1 - 1.4e-25 88.4 0.3 2.7e-25 87.5 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA17169.1 - 2.7e-11 42.9 0.1 2.7e-11 42.9 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA17169.1 - 0.00021 21.4 0.4 0.00082 19.5 0.3 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain PARP PF00644.15 ESA17169.1 - 0.0026 17.2 0.0 0.0044 16.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3990 PF13151.1 ESA17169.1 - 0.054 12.8 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DEAD PF00270.24 ESA17170.1 - 3.7e-47 159.9 0.0 9.8e-47 158.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA17170.1 - 3.3e-21 74.9 0.1 1.2e-20 73.0 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 ESA17170.1 - 1.4e-18 66.3 3.1 6.4e-18 64.3 2.1 2.2 1 0 0 1 1 1 1 DBP10CT (NUC160) domain DUF927 PF06048.6 ESA17170.1 - 0.017 14.4 0.7 0.036 13.3 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF927) Usp PF00582.21 ESA17171.1 - 0.055 13.6 0.1 0.078 13.1 0.0 1.3 1 1 0 1 1 1 0 Universal stress protein family Brr6_like_C_C PF10104.4 ESA17173.1 - 1.1 8.7 8.2 0.13 11.8 2.5 1.7 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain BTB PF00651.26 ESA17174.1 - 3.1e-17 62.5 0.3 5.8e-17 61.6 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA17174.1 - 5.9e-13 49.0 1.8 7.2e-13 48.7 0.3 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA17174.1 - 3.9e-06 26.6 0.6 0.016 15.0 0.2 4.0 1 1 2 3 3 3 2 BTB And C-terminal Kelch DUF4543 PF15076.1 ESA17175.1 - 0.015 15.2 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) SlyX PF04102.7 ESA17175.1 - 0.21 12.0 1.9 0.36 11.2 1.3 1.5 1 1 0 1 1 1 0 SlyX BLOC1_2 PF10046.4 ESA17175.1 - 0.23 11.6 1.7 0.4 10.8 1.2 1.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.3 ESA17176.1 - 3e-14 52.5 12.6 3e-14 52.5 8.7 5.8 5 1 2 7 7 7 1 TATA element modulatory factor 1 DNA binding DdrB PF12747.2 ESA17176.1 - 0.17 11.5 1.6 0.24 11.1 0.3 1.8 2 0 0 2 2 2 0 DdrB-like protein TMF_TATA_bd PF12325.3 ESA17177.1 - 8.8e-14 51.2 3.8 8.8e-14 51.2 2.6 3.6 2 1 1 3 3 3 1 TATA element modulatory factor 1 TATA binding DivIC PF04977.10 ESA17177.1 - 0.0063 15.9 2.8 0.0063 15.9 2.0 4.3 2 2 3 5 5 4 2 Septum formation initiator CCDC155 PF14662.1 ESA17177.1 - 0.011 15.2 3.2 0.011 15.2 2.2 3.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 CENP-F_leu_zip PF10473.4 ESA17177.1 - 0.011 15.5 50.6 0.62 9.9 3.0 3.9 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.1 ESA17177.1 - 0.013 15.3 13.1 0.013 15.3 9.1 3.5 2 2 1 3 3 3 0 Domain of unknown function (DUF4200) Flagellin_C PF00700.16 ESA17177.1 - 0.053 13.6 5.1 1 9.5 0.3 3.1 2 1 1 3 3 3 0 Bacterial flagellin C-terminal helical region RolB_RolC PF02027.12 ESA17177.1 - 0.072 12.2 1.0 0.17 11.0 0.7 1.7 1 0 0 1 1 1 0 RolB/RolC glucosidase family AIRC PF00731.15 ESA17177.1 - 0.096 11.9 1.4 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 AIR carboxylase Baculo_PEP_C PF04513.7 ESA17177.1 - 0.21 11.4 14.3 0.33 10.7 3.2 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HalX PF08663.5 ESA17177.1 - 0.22 11.5 0.1 0.22 11.5 0.1 4.1 2 2 1 4 4 4 0 HalX domain Lectin_N PF03954.9 ESA17177.1 - 0.26 10.6 12.9 2.6 7.4 6.8 2.9 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain NPV_P10 PF05531.7 ESA17177.1 - 0.27 11.4 15.8 0.83 9.9 1.6 4.3 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.6 ESA17177.1 - 0.41 10.5 9.4 0.069 13.0 1.1 3.1 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.2 ESA17177.1 - 0.63 9.8 44.9 1.4 8.7 1.8 4.0 2 1 1 3 3 3 0 Tropomyosin like DUF3584 PF12128.3 ESA17177.1 - 1 6.5 32.9 1.1 6.4 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Hemagglutinin PF00509.13 ESA17177.1 - 1.1 7.2 7.5 0.23 9.5 1.4 2.2 2 1 0 2 2 2 0 Haemagglutinin Reo_sigmaC PF04582.7 ESA17177.1 - 1.4 8.0 9.6 1.9 7.5 1.1 2.4 1 1 1 3 3 3 0 Reovirus sigma C capsid protein DNA_photolyase PF00875.13 ESA17177.1 - 2.4 7.8 5.9 1.7 8.4 1.7 2.2 2 0 0 2 2 2 0 DNA photolyase DUF2353 PF09789.4 ESA17177.1 - 3.1 6.9 30.8 1.5 7.9 16.9 2.1 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF1664 PF07889.7 ESA17177.1 - 3.4 7.4 22.8 0.091 12.5 2.8 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.6 ESA17177.1 - 3.5 7.4 40.6 0.068 12.9 1.9 3.1 1 1 1 3 3 2 0 Autophagy protein 16 (ATG16) IncA PF04156.9 ESA17177.1 - 3.6 7.1 48.5 0.06 12.9 9.9 3.1 1 1 2 3 3 3 0 IncA protein DUF2433 PF10360.4 ESA17177.1 - 9 6.6 8.3 0.67 10.2 1.5 2.2 2 1 1 3 3 2 0 Protein of unknown function (DUF2433) DSPc PF00782.15 ESA17178.1 - 1.4e-30 105.6 0.0 2.7e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.15 ESA17178.1 - 4.9e-07 30.0 0.2 0.0011 19.2 0.0 3.3 2 1 0 2 2 2 2 Rhodanese-like domain Y_phosphatase PF00102.22 ESA17178.1 - 0.00053 19.3 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.8 ESA17178.1 - 0.0079 15.5 0.2 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 ESA17178.1 - 0.014 15.7 0.0 0.071 13.3 0.0 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family PTPlike_phytase PF14566.1 ESA17178.1 - 0.077 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Curlin_rpt PF07012.7 ESA17178.1 - 0.11 12.2 2.6 0.3 10.8 1.8 1.8 1 0 0 1 1 1 0 Curlin associated repeat Glyco_hydro_9 PF00759.14 ESA17178.1 - 1.9 7.3 4.7 2.6 6.8 2.4 1.8 2 0 0 2 2 2 0 Glycosyl hydrolase family 9 M20_dimer PF07687.9 ESA17179.1 - 3.6e-10 39.5 0.0 8.6e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.23 ESA17179.1 - 4.1e-07 29.7 1.3 5.1e-07 29.3 0.9 1.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Dimer_Tnp_hAT PF05699.9 ESA17180.1 - 8.5e-07 28.5 0.2 2.5e-06 27.0 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region zf-U1 PF06220.7 ESA17180.1 - 0.0087 15.6 2.8 0.022 14.2 1.9 1.7 1 0 0 1 1 1 1 U1 zinc finger DUF3496 PF12001.3 ESA17184.1 - 0.021 15.0 0.4 0.021 15.0 0.3 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) OTT_1508_deam PF14441.1 ESA17185.1 - 0.057 13.2 1.2 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 OTT_1508-like deaminase V_ATPase_I PF01496.14 ESA17185.1 - 0.074 10.9 9.2 0.11 10.3 6.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2393 PF09624.5 ESA17185.1 - 0.11 11.9 4.2 4.6 6.7 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2393) APG6 PF04111.7 ESA17185.1 - 0.18 10.8 15.4 0.3 10.0 10.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 HAUS6_N PF14661.1 ESA17185.1 - 0.44 9.8 7.6 0.75 9.1 5.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Laminin_II PF06009.7 ESA17185.1 - 0.66 9.7 5.9 1.3 8.7 4.1 1.4 1 0 0 1 1 1 0 Laminin Domain II Nop14 PF04147.7 ESA17185.1 - 1.3 6.8 27.5 1.8 6.3 19.0 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA17185.1 - 6.9 4.5 12.6 10 4.0 8.7 1.3 1 0 0 1 1 1 0 CDC45-like protein zf-RING_4 PF14570.1 ESA17186.1 - 0.091 12.3 1.9 0.24 10.9 1.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Methyltransf_11 PF08241.7 ESA17187.1 - 1.2e-09 38.5 0.0 1.5e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17187.1 - 3.1e-08 33.8 0.0 4.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA17187.1 - 0.00012 21.6 0.0 0.00037 20.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA17187.1 - 0.00015 21.5 0.0 0.00019 21.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA17187.1 - 0.00026 20.2 0.0 0.00038 19.6 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA17187.1 - 0.0031 18.0 0.0 0.011 16.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA17187.1 - 0.039 14.4 0.0 0.08 13.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESA17188.1 - 7.2e-14 52.0 0.0 1.3e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17188.1 - 2.5e-12 47.0 0.0 4.9e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA17188.1 - 9.5e-12 44.7 0.0 2.4e-11 43.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA17188.1 - 1.4e-08 34.5 0.0 2.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA17188.1 - 2.7e-08 34.3 0.0 8.8e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA17188.1 - 4.2e-07 30.3 0.0 1.2e-06 28.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA17188.1 - 1.2e-06 27.7 0.0 8.8e-06 24.9 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA17188.1 - 6.4e-06 25.3 0.1 2.1e-05 23.6 0.0 2.0 1 1 1 2 2 2 1 Putative methyltransferase MetW PF07021.7 ESA17188.1 - 2.2e-05 23.9 0.0 4.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 ESA17188.1 - 9.1e-05 22.5 0.0 0.00073 19.5 0.0 2.2 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA17188.1 - 0.00059 19.8 0.0 0.0012 18.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA17188.1 - 0.0016 18.1 0.0 0.0037 16.9 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase TehB PF03848.9 ESA17188.1 - 0.0019 17.3 0.0 0.004 16.3 0.0 1.6 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_29 PF03141.11 ESA17188.1 - 0.0037 15.6 0.0 0.015 13.6 0.0 1.8 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Orthopox_B11R PF07033.6 ESA17190.1 - 0.35 10.3 3.5 0.56 9.7 2.4 1.3 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Toxin_35 PF10530.4 ESA17191.1 - 0.095 12.7 0.4 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold ABC2_membrane PF01061.19 ESA17193.1 - 2.2e-27 95.6 17.2 2.8e-27 95.2 11.9 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 ESA17193.1 - 0.00088 18.4 21.1 0.004 16.2 14.6 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein Vma12 PF11712.3 ESA17193.1 - 9.5 5.9 6.4 1.5 8.5 0.2 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Pkinase_Tyr PF07714.12 ESA17194.1 - 1.8e-30 105.9 0.0 2.1e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17194.1 - 5.7e-29 101.0 0.1 6.4e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA17194.1 - 1e-05 24.6 0.0 1.3e-05 24.3 0.0 1.0 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA17194.1 - 0.0064 15.8 0.1 0.0085 15.4 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA17194.1 - 0.0081 15.5 0.2 0.011 15.1 0.2 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA17194.1 - 0.025 13.8 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA17194.1 - 0.055 12.5 0.0 0.062 12.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DEAD PF00270.24 ESA17197.1 - 3.2e-41 140.6 0.0 7.1e-41 139.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA17197.1 - 1.3e-16 60.2 0.1 2.4e-15 56.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESA17197.1 - 0.00022 20.1 0.0 0.00044 19.1 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 ESA17197.1 - 0.032 14.0 0.0 0.032 14.0 0.0 3.4 1 1 3 4 4 4 0 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 ESA17197.1 - 0.088 12.7 0.0 0.49 10.3 0.0 2.3 3 0 0 3 3 3 0 Helicase C-terminal domain DUF4137 PF13593.1 ESA17197.1 - 0.23 10.5 0.0 0.34 9.9 0.0 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) AAA_22 PF13401.1 ESA17197.1 - 0.28 11.3 3.4 1.1 9.3 1.7 2.5 1 1 0 1 1 1 0 AAA domain Apc9 PF12856.2 ESA17197.1 - 0.7 10.0 15.6 0.37 10.9 8.4 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 9 RRM_6 PF14259.1 ESA17198.1 - 4.4e-10 39.4 0.0 5.8e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA17198.1 - 4.6e-10 38.9 0.0 6.2e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA17198.1 - 1.3e-09 37.7 0.0 1.7e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-BED PF02892.10 ESA17200.1 - 0.00096 18.8 2.0 0.0017 18.0 1.4 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA17200.1 - 0.016 15.5 1.2 0.051 13.9 0.9 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.7 ESA17200.1 - 0.067 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 ESA17200.1 - 0.085 13.1 1.0 0.25 11.6 0.7 1.9 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.1 ESA17200.1 - 0.11 12.8 3.9 3.6 8.0 0.1 2.8 3 0 0 3 3 3 0 Zinc-finger double domain ROS_MUCR PF05443.6 ESA17200.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein zf-C2H2_jaz PF12171.3 ESA17200.1 - 0.65 10.2 3.6 0.48 10.6 0.8 2.1 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Hexapep PF00132.19 ESA17202.1 - 1.8e-11 43.0 16.4 2.8e-08 32.9 1.3 4.4 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESA17202.1 - 8.6e-07 28.4 11.9 0.00026 20.4 2.3 4.2 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 ESA17202.1 - 0.028 12.9 0.1 0.044 12.3 0.1 1.3 1 0 0 1 1 1 0 L-fucokinase Med17 PF10156.4 ESA17204.1 - 5.2e-43 146.9 1.1 8.2e-43 146.3 0.8 1.2 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Sua5_yciO_yrdC PF01300.13 ESA17206.1 - 4.7e-52 175.8 0.0 6.6e-52 175.3 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 ESA17206.1 - 1.1e-27 96.5 0.0 2e-27 95.7 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Pkinase_Tyr PF07714.12 ESA17209.1 - 0.00022 20.4 0.2 0.00053 19.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DnaJ PF00226.26 ESA17209.1 - 0.0069 16.0 0.2 0.041 13.6 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain Cu-oxidase_3 PF07732.10 ESA17211.1 - 1.9e-29 101.7 0.1 2.3e-29 101.5 0.1 1.1 1 0 0 1 1 1 1 Multicopper oxidase Suc_Fer-like PF06999.7 ESA17213.1 - 2.4e-54 184.7 0.6 3e-54 184.4 0.4 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DEDD_Tnp_IS110 PF01548.12 ESA17213.1 - 0.021 14.4 0.0 0.079 12.6 0.0 2.0 1 0 0 1 1 1 0 Transposase LMBR1 PF04791.11 ESA17213.1 - 0.03 12.9 0.4 0.042 12.4 0.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Cu-oxidase_3 PF07732.10 ESA17214.1 - 6.9e-11 41.9 0.0 9.3e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 Multicopper oxidase Ion_trans PF00520.26 ESA17215.1 - 0.0088 15.3 12.3 0.012 14.8 8.5 1.2 1 0 0 1 1 1 1 Ion transport protein Sel1 PF08238.7 ESA17222.1 - 1.1e-56 187.9 10.1 1.2e-10 41.6 0.4 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA17222.1 - 0.00038 20.7 7.3 10 6.8 0.0 5.1 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17222.1 - 0.068 13.4 7.6 7.2 7.0 0.1 5.2 3 1 2 5 5 5 0 Tetratricopeptide repeat FTCD_N PF07837.7 ESA17222.1 - 0.12 11.8 0.1 3.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Formiminotransferase domain, N-terminal subdomain TPR_11 PF13414.1 ESA17222.1 - 0.4 10.3 11.1 3.2 7.4 1.3 4.1 3 2 1 4 4 4 0 TPR repeat Kelch_3 PF13415.1 ESA17224.1 - 1e-12 47.8 3.1 3.2e-05 23.9 0.1 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA17224.1 - 9.4e-12 44.6 6.0 1.1e-05 25.3 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA17224.1 - 1.8e-10 40.3 9.1 0.00028 20.5 0.1 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA17224.1 - 3.4e-09 36.0 0.1 0.0011 18.6 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.20 ESA17224.1 - 3.5e-06 26.4 14.1 0.13 11.8 0.0 5.1 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 ESA17224.1 - 1.1e-05 25.4 11.1 0.18 12.0 0.1 4.6 4 1 1 5 5 5 2 Kelch motif Rax2 PF12768.2 ESA17224.1 - 0.096 11.8 0.0 10 5.2 0.0 2.3 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Sel1 PF08238.7 ESA17225.1 - 9.9e-46 153.1 19.1 2.2e-11 44.0 1.6 5.7 5 1 1 6 6 6 5 Sel1 repeat DUF843 PF05814.6 ESA17227.1 - 0.043 13.6 0.7 1.7 8.5 0.1 2.3 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) DUF2191 PF09957.4 ESA17227.1 - 0.1 12.4 1.2 2.8 7.8 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2191) PB1 PF00564.19 ESA17228.1 - 2e-12 46.5 0.0 4.2e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 PB1 domain BTB_2 PF02214.17 ESA17229.1 - 8.5e-19 67.5 1.6 1e-18 67.2 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain Asn_synthase PF00733.16 ESA17230.1 - 5.6e-50 170.2 0.0 7.9e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 ESA17230.1 - 4.3e-09 36.1 0.0 1.1e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 ESA17230.1 - 8.7e-05 22.4 0.0 0.0002 21.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain ADP_ribosyl_GH PF03747.9 ESA17231.1 - 4.7e-61 207.1 0.0 4.2e-41 141.6 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylglycohydrolase Gly-zipper_Omp PF13488.1 ESA17231.1 - 0.003 17.1 0.3 0.74 9.4 0.1 2.6 2 0 0 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.1 ESA17231.1 - 0.0074 15.7 0.8 1.3 8.5 0.2 2.6 2 0 0 2 2 2 2 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.10 ESA17231.1 - 0.022 14.3 4.7 0.1 12.2 0.4 2.6 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_OmpA PF13436.1 ESA17231.1 - 0.1 12.2 0.3 16 5.1 0.0 2.6 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain HA2 PF04408.18 ESA17232.1 - 8.5e-24 83.5 0.0 8.5e-24 83.5 0.0 2.2 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESA17232.1 - 1.1e-14 54.0 0.0 3.8e-14 52.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 ESA17232.1 - 4.9e-08 32.7 0.3 1.1e-07 31.6 0.2 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.24 ESA17232.1 - 3.4e-07 29.8 0.0 1.3e-06 28.0 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 ESA17232.1 - 6.7e-06 26.2 0.0 2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA17232.1 - 0.00053 18.9 0.0 0.0013 17.6 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.10 ESA17232.1 - 0.0022 17.8 9.9 0.016 15.0 0.1 3.6 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESA17232.1 - 0.0073 16.0 0.0 0.021 14.5 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain SRP54 PF00448.17 ESA17232.1 - 0.0076 15.7 0.0 4.6 6.6 0.0 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_23 PF13476.1 ESA17232.1 - 0.02 15.2 0.1 0.02 15.2 0.1 2.9 2 1 0 2 2 1 0 AAA domain Miro PF08477.8 ESA17232.1 - 0.024 15.1 0.0 0.12 12.8 0.0 2.2 1 0 0 1 1 1 0 Miro-like protein PhoH PF02562.11 ESA17232.1 - 0.045 12.9 0.0 0.17 11.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_29 PF13555.1 ESA17232.1 - 0.079 12.5 0.1 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.1 ESA17232.1 - 0.13 11.8 0.0 0.38 10.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESA17232.1 - 0.48 10.7 2.3 0.7 10.1 0.0 2.4 3 0 0 3 3 3 0 ABC transporter AAA_11 PF13086.1 ESA17232.1 - 1.6 8.2 11.8 2.6 7.5 0.0 4.0 3 1 0 4 4 4 0 AAA domain STE3 PF02076.10 ESA17233.1 - 3.9e-06 26.1 3.9 4.6e-06 25.9 2.7 1.0 1 0 0 1 1 1 1 Pheromone A receptor 7tm_2 PF00002.19 ESA17233.1 - 5.5e-06 25.6 5.2 6.7e-06 25.3 3.6 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.6 ESA17233.1 - 0.00048 19.1 3.5 0.00056 18.9 2.4 1.1 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor DUF1475 PF07343.6 ESA17233.1 - 0.0024 17.2 0.7 0.0033 16.8 0.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1475) PrgI PF12666.2 ESA17233.1 - 2.7 8.2 4.9 8.7 6.5 0.1 2.9 2 1 1 3 3 3 0 PrgI family protein LtrA PF06772.6 ESA17234.1 - 0.00019 20.4 0.3 0.00027 19.9 0.2 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) LUC7 PF03194.10 ESA17234.1 - 0.0032 17.0 6.2 0.0032 17.0 4.3 1.9 2 0 0 2 2 2 1 LUC7 N_terminus Laminin_II PF06009.7 ESA17234.1 - 0.0051 16.5 13.4 0.0071 16.1 2.8 2.2 2 0 0 2 2 2 1 Laminin Domain II CENP-Q PF13094.1 ESA17234.1 - 0.021 14.8 8.0 0.021 14.8 5.6 2.0 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit OmpH PF03938.9 ESA17234.1 - 0.024 14.5 14.2 0.034 14.0 9.8 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GvpK PF05121.7 ESA17234.1 - 0.079 12.7 2.3 0.19 11.5 0.6 2.2 1 1 1 2 2 2 0 Gas vesicle protein K DUF972 PF06156.8 ESA17234.1 - 0.13 12.5 13.4 0.34 11.2 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Spectrin PF00435.16 ESA17234.1 - 0.34 11.2 11.3 0.055 13.7 4.4 2.0 2 0 0 2 2 2 0 Spectrin repeat Macoilin PF09726.4 ESA17234.1 - 0.5 8.5 9.0 0.61 8.2 6.2 1.0 1 0 0 1 1 1 0 Transmembrane protein eIF3_N PF09440.5 ESA17234.1 - 0.53 10.4 10.3 3.3 7.8 1.5 2.2 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain Fib_alpha PF08702.5 ESA17234.1 - 0.59 10.2 10.5 0.32 11.1 0.6 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Glutaredoxin2_C PF04399.8 ESA17234.1 - 0.6 9.6 5.7 0.11 12.0 0.7 2.0 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Allexi_40kDa PF05549.6 ESA17234.1 - 0.62 9.3 6.3 0.075 12.3 0.7 1.8 2 0 0 2 2 2 0 Allexivirus 40kDa protein AAA_27 PF13514.1 ESA17234.1 - 1 6.9 13.3 0.048 11.3 5.5 1.4 2 0 0 2 2 2 0 AAA domain DASH_Dad3 PF08656.5 ESA17234.1 - 1.3 8.7 8.7 0.21 11.2 0.2 3.0 2 1 1 3 3 3 0 DASH complex subunit Dad3 DUF2203 PF09969.4 ESA17234.1 - 1.7 8.8 9.5 1.2 9.3 2.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) FemAB PF02388.11 ESA17234.1 - 2 7.0 14.2 0.22 10.1 3.9 2.0 2 0 0 2 2 2 0 FemAB family DUF4337 PF14235.1 ESA17234.1 - 2 8.2 7.7 0.15 11.9 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) MT PF12777.2 ESA17234.1 - 2.5 6.7 8.8 1.7 7.2 2.1 2.2 1 1 1 2 2 2 0 Microtubule-binding stalk of dynein motor APG6 PF04111.7 ESA17234.1 - 2.8 6.8 14.3 0.081 11.9 2.7 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 AAA_23 PF13476.1 ESA17234.1 - 2.9 8.1 11.8 4.4 7.5 8.2 1.2 1 0 0 1 1 1 0 AAA domain DUF904 PF06005.7 ESA17234.1 - 3.6 7.9 16.4 0.078 13.2 5.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF904) Atg14 PF10186.4 ESA17234.1 - 3.8 6.3 8.4 2 7.3 4.5 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 ESA17234.1 - 4.3 5.9 13.6 0.13 10.8 1.8 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Med4 PF10018.4 ESA17234.1 - 6.9 6.0 12.2 0.16 11.3 3.7 1.7 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 TPR_MLP1_2 PF07926.7 ESA17234.1 - 8.7 6.0 20.3 1.9 8.2 7.5 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF948 PF06103.6 ESA17234.1 - 10 6.0 10.7 0.41 10.5 1.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LtrA PF06772.6 ESA17235.1 - 1.8e-13 50.1 1.4 1.8e-13 50.1 1.0 2.2 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF1435 PF07256.7 ESA17235.1 - 5.9 6.9 8.0 1.6 8.7 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) T2SI PF02501.12 ESA17237.1 - 0.044 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I Sel1 PF08238.7 ESA17239.1 - 5.7e-06 26.7 2.8 1.1e-05 25.8 0.0 2.5 3 0 0 3 3 3 1 Sel1 repeat JHBP PF06585.6 ESA17241.1 - 0.14 10.9 0.2 0.17 10.6 0.2 1.1 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) P2X_receptor PF00864.14 ESA17243.1 - 0.012 14.2 0.5 0.051 12.2 0.5 1.9 2 1 0 2 2 2 0 ATP P2X receptor ABC_membrane_2 PF06472.10 ESA17244.1 - 0.15 11.2 0.1 0.17 11.0 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Claudin_2 PF13903.1 ESA17245.1 - 0.22 11.2 6.6 2.4 7.8 4.6 2.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction UPF0081 PF03652.10 ESA17245.1 - 2.5 8.2 6.6 0.81 9.7 1.4 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0081) AAA_18 PF13238.1 ESA17246.1 - 0.068 13.4 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESA17246.1 - 0.092 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Asp_protease_2 PF13650.1 ESA17247.1 - 0.003 18.0 0.0 0.0068 16.8 0.0 1.6 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA17247.1 - 0.081 12.7 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF1758 PF05585.7 ESA17247.1 - 0.14 11.6 0.4 0.57 9.7 0.3 2.0 1 1 0 1 1 1 0 Putative peptidase (DUF1758) ThiS-like PF14453.1 ESA17248.1 - 0.053 13.3 0.2 0.077 12.8 0.1 1.2 1 0 0 1 1 1 0 ThiS-like ubiquitin Ubiq_cyt_C_chap PF03981.7 ESA17250.1 - 1.7e-32 112.1 0.0 2.4e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone WD40 PF00400.27 ESA17252.1 - 3.8e-16 58.2 0.2 0.00012 21.7 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 ESA17252.1 - 2.5e-06 26.0 0.2 8.4e-05 21.0 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain eIF2A PF08662.6 ESA17252.1 - 0.00033 20.4 0.0 0.014 15.0 0.0 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Citrate_synt PF00285.16 ESA17253.1 - 2.2e-100 335.8 0.0 2.6e-100 335.6 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase Ribosomal_L9_N PF01281.14 ESA17254.1 - 9.9e-14 50.3 0.4 1.7e-13 49.5 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain zf-ZPR1 PF03367.8 ESA17255.1 - 0.011 14.9 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain RRM_1 PF00076.17 ESA17256.1 - 4.6e-21 74.2 0.1 6.6e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA17256.1 - 3e-14 52.7 0.0 4.1e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA17256.1 - 3.3e-07 30.0 0.1 4.9e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Utp12 PF04003.7 ESA17257.1 - 2e-18 66.3 0.2 3.6e-18 65.4 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.27 ESA17257.1 - 4.1e-05 23.3 0.4 0.24 11.3 0.0 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF788 PF05620.6 ESA17258.1 - 9.3e-50 168.7 4.2 1.1e-49 168.6 2.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) Adap_comp_sub PF00928.16 ESA17259.1 - 7.6e-24 84.2 0.1 1.2e-23 83.5 0.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 ESA17259.1 - 1.5e-07 31.1 0.1 2.5e-07 30.4 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Trp_syntA PF00290.15 ESA17260.1 - 1.2e-88 296.0 0.1 1.7e-88 295.4 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 ESA17260.1 - 1.4e-46 159.1 0.4 2.6e-46 158.2 0.3 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme His_biosynth PF00977.16 ESA17260.1 - 0.018 14.3 0.2 0.049 12.9 0.0 1.7 2 0 0 2 2 2 0 Histidine biosynthesis protein PcrB PF01884.12 ESA17260.1 - 0.048 12.9 0.3 0.24 10.6 0.1 2.0 2 0 0 2 2 2 0 PcrB family Glyco_transf_15 PF01793.11 ESA17261.1 - 3e-107 358.4 15.7 3.4e-107 358.2 10.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase p450 PF00067.17 ESA17263.1 - 1.5e-49 168.8 0.0 1.8e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 YMF19 PF02326.10 ESA17263.1 - 1.4 9.5 5.0 1.1 9.9 0.1 2.7 3 0 0 3 3 3 0 Plant ATP synthase F0 Herpes_BLRF2 PF05812.7 ESA17264.1 - 0.012 15.4 0.8 0.012 15.4 0.6 1.5 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein TSC22 PF01166.13 ESA17264.1 - 0.12 12.3 2.1 0.1 12.5 0.7 1.5 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF2046 PF09755.4 ESA17264.1 - 0.15 10.9 4.8 0.15 10.8 3.3 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) YgaB PF14182.1 ESA17264.1 - 0.23 11.6 2.7 0.24 11.6 1.9 1.0 1 0 0 1 1 1 0 YgaB-like protein DUF3073 PF11273.3 ESA17264.1 - 0.5 10.9 2.8 0.55 10.8 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) Zn_clus PF00172.13 ESA17265.1 - 7.4e-08 32.1 10.0 1.4e-07 31.2 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.2 ESA17267.1 - 0.0016 18.1 0.3 0.0099 15.5 0.1 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA17267.1 - 0.0054 16.3 3.5 0.011 15.4 0.4 2.7 3 0 0 3 3 3 1 F-box domain F-box PF00646.28 ESA17268.1 - 0.0012 18.4 1.4 0.0054 16.3 0.3 2.6 2 0 0 2 2 2 1 F-box domain Fer4_12 PF13353.1 ESA17268.1 - 0.0036 17.4 0.3 0.28 11.2 0.0 2.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain FBD PF08387.5 ESA17268.1 - 0.0094 15.3 0.3 0.0094 15.3 0.2 3.3 4 0 0 4 4 4 1 FBD F-box-like PF12937.2 ESA17268.1 - 2.1 8.1 10.4 0.058 13.1 1.7 2.5 3 0 0 3 3 3 0 F-box-like Sel1 PF08238.7 ESA17269.1 - 7e-79 258.5 22.2 1.6e-10 41.2 0.3 9.3 9 0 0 9 9 9 9 Sel1 repeat Pkinase_Tyr PF07714.12 ESA17269.1 - 8.6e-36 123.3 0.0 1.5e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17269.1 - 1.7e-31 109.3 0.0 3.1e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain MIT PF04212.13 ESA17269.1 - 0.00063 19.5 30.3 0.034 14.0 0.3 6.9 3 2 3 7 7 7 3 MIT (microtubule interacting and transport) domain Kinase-like PF14531.1 ESA17269.1 - 0.0015 17.5 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA17269.1 - 0.0073 16.0 0.5 0.017 14.8 0.4 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA17269.1 - 0.0084 15.1 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA17269.1 - 0.02 14.2 0.1 0.042 13.2 0.1 1.5 1 0 0 1 1 1 0 RIO1 family EF-hand_10 PF14788.1 ESA17269.1 - 0.1 12.2 5.1 7.7 6.2 0.1 5.0 6 0 0 6 6 6 0 EF hand TPR_11 PF13414.1 ESA17269.1 - 1.3 8.6 34.4 0.14 11.7 1.7 6.6 2 2 5 7 7 7 0 TPR repeat Sel1 PF08238.7 ESA17271.1 - 6.6e-151 487.4 82.8 4.3e-12 46.2 0.5 18.4 18 0 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA17271.1 - 9.1e-11 41.4 41.5 0.4 11.2 0.1 13.7 16 0 0 16 16 16 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESA17271.1 - 0.0074 15.8 0.5 0.0074 15.8 0.4 15.8 20 0 0 20 20 20 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA17271.1 - 0.051 13.4 0.3 0.051 13.4 0.2 13.6 21 0 0 21 21 21 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17271.1 - 0.1 13.2 2.6 9.4 7.1 0.0 4.9 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17271.1 - 0.11 12.4 0.2 0.11 12.4 0.7 8.8 5 3 5 10 10 10 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17271.1 - 0.74 9.7 5.8 9.5 6.3 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_Tnp_IS630 PF01710.11 ESA17272.1 - 0.0042 16.7 0.7 0.0061 16.2 0.5 1.3 1 0 0 1 1 1 1 Transposase HTH_Tnp_Tc5 PF03221.11 ESA17272.1 - 0.081 12.7 1.8 0.087 12.6 0.4 1.8 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain zf-C3HC4_3 PF13920.1 ESA17274.1 - 1.4e-05 24.6 8.6 1.4e-05 24.6 6.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA17274.1 - 0.0009 18.8 8.7 0.0009 18.8 6.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA17274.1 - 0.0023 17.7 10.5 0.0023 17.7 7.3 1.9 2 0 0 2 2 2 1 Ring finger domain zf-dskA_traR PF01258.12 ESA17274.1 - 0.003 17.2 10.5 0.34 10.6 0.4 3.5 3 0 0 3 3 3 2 Prokaryotic dksA/traR C4-type zinc finger zf-C3HC4_2 PF13923.1 ESA17274.1 - 0.0074 16.2 10.1 0.0074 16.2 7.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA17274.1 - 0.01 15.5 10.1 0.01 15.5 7.0 2.1 2 0 0 2 2 2 0 zinc-RING finger domain DZR PF12773.2 ESA17274.1 - 6.5 6.6 13.5 11 5.9 3.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon RVP_2 PF08284.6 ESA17275.1 - 1.5e-10 41.1 0.0 2.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA17275.1 - 1.5e-06 27.7 0.0 2.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESA17275.1 - 5e-06 26.9 0.0 7.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA17275.1 - 0.00012 21.7 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2B PF12384.3 ESA17275.1 - 0.0067 15.7 0.1 0.014 14.7 0.0 1.5 1 1 0 1 1 1 1 Ty3 transposon peptidase CobT PF06213.7 ESA17275.1 - 0.076 12.1 11.7 0.12 11.5 8.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Daxx PF03344.10 ESA17275.1 - 7.3 4.9 19.1 9.9 4.5 13.2 1.2 1 0 0 1 1 1 0 Daxx Family RNase_H PF00075.19 ESA17276.1 - 1.3e-06 28.7 1.0 0.00063 20.0 0.1 2.3 1 1 0 2 2 2 2 RNase H Pkinase PF00069.20 ESA17277.1 - 3.7e-30 104.9 0.0 3e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17277.1 - 6.9e-30 103.9 0.0 1.4e-29 102.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA17277.1 - 0.073 12.7 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Myb_DNA-bind_3 PF12776.2 ESA17278.1 - 0.0029 18.1 13.5 0.22 12.1 0.6 3.6 2 1 2 4 4 4 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA17278.1 - 0.052 13.6 10.2 0.2 11.7 0.1 3.5 3 1 1 4 4 4 0 Myb-like DNA-binding domain Retrotrans_gag PF03732.12 ESA17278.1 - 0.08 13.0 0.2 0.08 13.0 0.1 2.5 2 0 0 2 2 2 0 Retrotransposon gag protein SPASM PF13186.1 ESA17278.1 - 2.5 8.5 5.9 4.4 7.7 1.7 2.8 2 1 0 2 2 2 0 Iron-sulfur cluster-binding domain Myb_DNA-binding PF00249.26 ESA17278.1 - 3 7.9 6.4 9 6.4 0.1 3.5 3 0 0 3 3 3 0 Myb-like DNA-binding domain BTB PF00651.26 ESA17282.1 - 1.4e-15 57.2 0.0 3e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Secretin_N_2 PF07655.8 ESA17282.1 - 0.00045 20.5 16.6 0.0009 19.5 11.5 1.4 1 0 0 1 1 1 1 Secretin N-terminal domain POX PF07526.6 ESA17282.1 - 0.1 12.8 1.0 0.17 12.1 0.7 1.2 1 0 0 1 1 1 0 Associated with HOX F-box-like PF12937.2 ESA17284.1 - 2.5e-05 23.9 0.9 9.9e-05 21.9 0.6 2.1 1 0 0 1 1 1 1 F-box-like BTB PF00651.26 ESA17285.1 - 1.9e-07 31.0 0.2 2.4e-07 30.7 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Ph1570 PF09638.5 ESA17285.1 - 0.1 12.4 1.0 0.17 11.6 0.7 1.5 1 1 0 1 1 1 0 Ph1570 protein Pyridoxal_deC PF00282.14 ESA17285.1 - 0.12 10.8 0.2 0.22 9.9 0.1 1.5 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain BTB PF00651.26 ESA17287.1 - 4.7e-13 49.0 0.1 4.9e-13 49.0 0.1 1.0 1 0 0 1 1 1 1 BTB/POZ domain Sel1 PF08238.7 ESA17288.1 - 1.9e-150 486.0 87.2 9.2e-11 42.0 1.7 17.0 17 0 0 17 17 17 17 Sel1 repeat TPR_6 PF13174.1 ESA17288.1 - 2.3e-10 40.2 40.4 0.52 10.8 0.3 12.0 12 0 0 12 12 12 7 Tetratricopeptide repeat Sel1 PF08238.7 ESA17289.1 - 1.6e-92 301.8 56.3 4.6e-09 36.6 1.4 14.1 14 0 0 14 14 14 14 Sel1 repeat TPR_6 PF13174.1 ESA17289.1 - 2e-07 30.9 25.0 1 9.9 0.1 10.1 11 0 0 11 11 11 4 Tetratricopeptide repeat Sec23_trunk PF04811.10 ESA17290.1 - 6.1e-70 235.3 0.0 1.1e-69 234.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 ESA17290.1 - 4.9e-27 93.3 0.1 1.1e-26 92.2 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 ESA17290.1 - 4.8e-19 68.6 0.0 1e-18 67.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 ESA17290.1 - 1.5e-18 66.0 1.9 3.4e-18 64.9 1.3 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 ESA17290.1 - 2.4e-11 43.1 0.0 5.5e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat PAGK PF15284.1 ESA17291.1 - 0.13 12.0 0.4 0.17 11.6 0.3 1.2 1 0 0 1 1 1 0 Phage-encoded virulence factor SipA PF09052.5 ESA17291.1 - 1.3 7.2 5.4 1.3 7.3 3.8 1.0 1 0 0 1 1 1 0 Salmonella invasion protein A F-box-like PF12937.2 ESA17292.1 - 1.5e-06 27.7 0.0 3.2e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA17292.1 - 6.2e-06 25.7 0.0 1.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain Cu_amine_oxidN1 PF07833.6 ESA17292.1 - 8.5 6.7 9.4 0.84 10.0 0.8 2.9 2 1 1 3 3 3 0 Copper amine oxidase N-terminal domain GBP PF02263.14 ESA17293.1 - 5.6e-42 143.5 0.0 5.6e-42 143.5 0.0 3.0 3 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 ESA17293.1 - 3e-06 26.6 26.8 3e-06 26.6 18.6 2.5 2 1 1 3 3 3 1 Guanylate-binding protein, C-terminal domain Dynamin_N PF00350.18 ESA17293.1 - 1.1 9.0 0.0 1.1 9.0 0.0 3.9 3 2 0 3 3 3 0 Dynamin family RuBisCO_small PF00101.15 ESA17294.1 - 0.12 12.2 0.7 0.47 10.3 0.0 2.0 2 1 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain PB1 PF00564.19 ESA17297.1 - 2.6e-12 46.2 0.1 6.3e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 PB1 domain UBA PF00627.26 ESA17297.1 - 0.028 14.2 2.4 0.038 13.8 0.0 2.3 2 0 0 2 2 2 0 UBA/TS-N domain CUE PF02845.11 ESA17297.1 - 0.11 12.0 1.5 0.2 11.1 0.0 2.2 2 0 0 2 2 2 0 CUE domain SseC PF04888.7 ESA17297.1 - 0.23 10.7 0.7 0.34 10.2 0.5 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Kelch_4 PF13418.1 ESA17299.1 - 2.7e-15 55.8 15.4 0.00073 19.2 0.0 6.7 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA17299.1 - 3.6e-13 49.2 3.7 0.019 15.1 0.0 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA17299.1 - 2.2e-10 40.2 13.2 0.097 12.8 0.0 6.5 4 2 2 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESA17299.1 - 2.5e-07 30.1 6.5 0.0039 16.7 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA17299.1 - 7.5e-07 28.6 2.5 0.18 11.6 0.0 5.2 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.1 ESA17299.1 - 1.6e-06 27.9 17.1 0.0043 16.9 0.2 6.5 6 1 0 6 6 6 2 Kelch motif ABC2_membrane_3 PF12698.2 ESA17299.1 - 0.017 14.1 4.0 0.038 13.0 2.8 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3169 PF11368.3 ESA17299.1 - 0.13 11.4 0.1 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Sel1 PF08238.7 ESA17300.1 - 2.5e-231 743.1 116.2 3.2e-12 46.6 1.5 25.0 25 0 0 25 25 25 25 Sel1 repeat TPR_6 PF13174.1 ESA17300.1 - 8.6e-16 57.2 54.9 0.75 10.3 0.3 18.4 20 1 0 20 20 20 9 Tetratricopeptide repeat RQC PF09382.5 ESA17300.1 - 2.3 7.9 10.9 13 5.5 0.2 5.1 5 1 0 5 5 5 0 RQC domain BAR_2 PF10455.4 ESA17302.1 - 0.013 14.4 2.2 0.24 10.2 0.1 2.2 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking PLDc_2 PF13091.1 ESA17302.1 - 0.037 13.7 1.6 0.081 12.6 0.9 1.7 1 1 0 1 1 1 0 PLD-like domain SBP PF03110.9 ESA17302.1 - 0.046 13.9 0.3 0.072 13.3 0.2 1.3 1 0 0 1 1 1 0 SBP domain DUF668 PF05003.7 ESA17302.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF668) BTB PF00651.26 ESA17303.1 - 2.5e-17 62.8 0.1 4.5e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA17303.1 - 4.5e-12 46.1 0.9 8.6e-12 45.2 0.7 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA17303.1 - 4.4e-05 23.2 4.9 7.1e-05 22.5 0.7 3.0 1 1 2 3 3 3 1 BTB And C-terminal Kelch RUN PF02759.14 ESA17304.1 - 0.0047 16.6 0.1 0.0049 16.6 0.1 1.1 1 0 0 1 1 1 1 RUN domain Tcf25 PF04910.9 ESA17306.1 - 0.12 11.2 0.2 0.13 11.1 0.1 1.0 1 0 0 1 1 1 0 Transcriptional repressor TCF25 Abhydrolase_6 PF12697.2 ESA17307.1 - 1e-30 107.3 0.0 1.3e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA17307.1 - 9.1e-13 48.1 0.0 2.5e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA17307.1 - 8.8e-12 45.0 0.0 2.7e-11 43.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 ESA17307.1 - 8.3e-08 31.9 0.0 1.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase DUF2305 PF10230.4 ESA17307.1 - 5.7e-05 22.6 0.0 0.00014 21.3 0.0 1.7 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Lipase_2 PF01674.13 ESA17307.1 - 0.00022 20.6 0.0 0.00042 19.6 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 2) PGAP1 PF07819.8 ESA17307.1 - 0.0047 16.5 0.0 0.02 14.5 0.0 2.0 2 1 0 2 2 2 1 PGAP1-like protein DUF1749 PF08538.5 ESA17307.1 - 0.092 11.6 0.1 0.6 8.9 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1749) Methyltransf_31 PF13847.1 ESA17308.1 - 1.3e-18 67.0 0.0 1.8e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA17308.1 - 1.3e-17 64.0 0.0 1.9e-17 63.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA17308.1 - 2.6e-15 56.4 0.0 3.9e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA17308.1 - 1.2e-14 54.5 0.0 2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA17308.1 - 7.7e-12 45.7 0.0 1.2e-11 45.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17308.1 - 5.2e-09 36.3 0.0 9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA17308.1 - 1.8e-07 30.6 0.0 2.8e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 ESA17308.1 - 6.1e-06 25.7 0.0 8.7e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.14 ESA17308.1 - 2.6e-05 23.8 0.0 3.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.6 ESA17308.1 - 0.00016 20.5 0.0 0.0002 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.13 ESA17308.1 - 0.00018 20.7 0.0 0.00027 20.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 ESA17308.1 - 0.0013 18.7 0.0 0.0025 17.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 ESA17308.1 - 0.0021 17.0 0.0 0.0029 16.5 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_32 PF13679.1 ESA17308.1 - 0.0038 16.9 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 ESA17308.1 - 0.0057 15.7 0.0 0.0085 15.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.8 ESA17308.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.6 ESA17308.1 - 0.029 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) N6_N4_Mtase PF01555.13 ESA17308.1 - 0.11 11.9 0.0 0.68 9.3 0.0 2.0 2 0 0 2 2 2 0 DNA methylase TehB PF03848.9 ESA17308.1 - 0.14 11.2 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 ESA17308.1 - 0.15 11.0 0.0 0.36 9.8 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase p450 PF00067.17 ESA17309.1 - 1.4e-56 191.9 1.0 2e-56 191.4 0.7 1.1 1 0 0 1 1 1 1 Cytochrome P450 Herpes_Helicase PF02689.9 ESA17310.1 - 1.1e-05 23.4 0.0 1.3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Helicase Pkinase_Tyr PF07714.12 ESA17310.1 - 0.002 17.2 0.1 0.004 16.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Helitron_like_N PF14214.1 ESA17311.1 - 4.4e-34 117.8 0.0 7.4e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus CTK3 PF12243.3 ESA17311.1 - 0.014 14.9 0.9 0.028 14.0 0.6 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 BTB PF00651.26 ESA17312.1 - 7.2e-17 61.3 0.0 1.3e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17312.1 - 4.5e-06 26.4 0.4 0.0022 17.8 0.0 2.8 1 1 2 3 3 3 2 BTB And C-terminal Kelch FANCI_S2 PF14676.1 ESA17312.1 - 0.052 13.4 0.5 0.089 12.6 0.3 1.4 1 0 0 1 1 1 0 FANCI solenoid 2 CLTH PF10607.4 ESA17312.1 - 0.077 12.6 2.7 0.13 11.9 0.5 2.0 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Pox_RNA_Pol_19 PF05320.7 ESA17314.1 - 0.22 11.2 0.9 0.24 11.1 0.6 1.0 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Peptidase_S41 PF03572.13 ESA17315.1 - 0.00048 19.5 0.0 0.0015 17.9 0.0 1.8 1 1 0 1 1 1 1 Peptidase family S41 Pkinase_Tyr PF07714.12 ESA17317.1 - 9.9e-19 67.4 0.2 1.1e-10 41.0 0.0 2.5 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17317.1 - 2.4e-11 43.3 0.0 1.2e-05 24.6 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Fer4_7 PF12838.2 ESA17318.1 - 0.00077 19.8 0.0 1.7 9.0 0.0 3.3 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESA17318.1 - 0.0044 17.2 5.7 6.3 7.1 0.1 3.6 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESA17318.1 - 0.0046 16.9 0.6 11 6.0 0.1 3.3 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 ESA17318.1 - 0.015 15.1 3.1 7.9 6.3 0.0 3.4 3 0 0 3 3 3 0 4Fe-4S dicluster domain DUF4134 PF13572.1 ESA17318.1 - 0.032 14.3 0.7 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4134) DUF2190 PF09956.4 ESA17318.1 - 0.067 12.9 4.7 5.4 6.8 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2190) DUF3602 PF12223.3 ESA17318.1 - 0.24 11.8 4.3 0.78 10.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3602) GspH PF12019.3 ESA17318.1 - 0.29 11.2 0.1 0.29 11.2 0.1 3.5 3 1 0 3 3 3 0 Type II transport protein GspH GHL15 PF14885.1 ESA17318.1 - 0.83 9.8 9.6 7.8 6.7 0.0 4.2 5 0 0 5 5 5 0 Hypothetical glycosyl hydrolase family 15 NUMOD3 PF07460.6 ESA17318.1 - 1 9.2 4.0 37 4.3 0.0 3.5 4 0 0 4 4 4 0 NUMOD3 motif (2 copies) Fer4_2 PF12797.2 ESA17318.1 - 1.2 9.2 11.7 15 5.7 0.3 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain MerB PF03243.10 ESA17320.1 - 3.6e-07 30.0 6.5 0.72 9.6 0.0 5.0 5 0 0 5 5 5 3 Alkylmercury lyase Fer4_7 PF12838.2 ESA17320.1 - 0.00047 20.4 4.8 31 5.0 0.0 5.1 5 0 0 5 5 5 3 4Fe-4S dicluster domain DUF2789 PF10982.3 ESA17320.1 - 0.01 15.8 4.9 1.8 8.6 0.1 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2789) Linker_histone PF00538.14 ESA17321.1 - 0.11 12.5 0.3 0.25 11.4 0.0 1.7 1 1 1 2 2 2 0 linker histone H1 and H5 family REV PF00424.13 ESA17322.1 - 0.0085 15.9 1.7 0.011 15.6 1.1 1.2 1 0 0 1 1 1 1 REV protein (anti-repression trans-activator protein) Imm3 PF14425.1 ESA17323.1 - 0.093 12.6 0.3 0.12 12.3 0.2 1.1 1 0 0 1 1 1 0 Immunity protein Imm3 Stb3 PF10330.4 ESA17323.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative Sin3 binding protein RRM_6 PF14259.1 ESA17324.1 - 0.00076 19.4 0.0 0.004 17.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA17324.1 - 0.0029 17.4 0.8 0.0079 16.0 0.5 1.8 1 0 0 1 1 1 1 Zinc knuckle RRM_1 PF00076.17 ESA17324.1 - 0.023 14.3 0.0 3.1 7.4 0.0 2.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_4 PF14392.1 ESA17324.1 - 0.081 12.6 1.0 0.26 10.9 0.7 1.9 1 1 0 1 1 1 0 Zinc knuckle PBP1_TM PF14812.1 ESA17324.1 - 1.8 8.8 13.4 2.9 8.2 1.5 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cas_Cas6 PF01881.11 ESA17325.1 - 0.51 10.5 5.1 0.14 12.4 0.9 1.8 2 0 0 2 2 2 0 CRISPR associated protein Cas6 HSP70 PF00012.15 ESA17326.1 - 0.00019 19.4 0.8 0.0071 14.3 0.3 2.7 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA17326.1 - 0.001 17.7 0.0 0.58 8.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA17327.1 - 5.2e-09 34.5 0.0 2.3e-08 32.4 0.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA17327.1 - 7.9e-07 27.9 0.0 0.0013 17.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein WXG100 PF06013.7 ESA17328.1 - 0.088 12.8 8.4 0.85 9.6 0.3 3.8 3 2 1 4 4 4 0 Proteins of 100 residues with WXG Reo_sigmaC PF04582.7 ESA17328.1 - 0.99 8.5 5.9 9.4 5.3 0.9 2.6 1 1 0 2 2 2 0 Reovirus sigma C capsid protein CCDC155 PF14662.1 ESA17328.1 - 9.9 5.7 51.4 3.1 7.3 1.4 3.4 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 BTB PF00651.26 ESA17329.1 - 6.3e-17 61.5 0.4 1.6e-16 60.2 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA17329.1 - 6.7e-09 35.8 0.1 1.8e-08 34.5 0.1 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA17329.1 - 8.1e-08 32.0 3.4 2.7e-07 30.3 0.5 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch Lactamase_B_2 PF12706.2 ESA17330.1 - 1.2e-11 44.5 0.0 1.7e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Met_gamma_lyase PF06838.6 ESA17331.1 - 0.14 10.4 0.2 0.16 10.2 0.1 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase Methyltransf_23 PF13489.1 ESA17333.1 - 9.3e-15 54.7 0.0 1.3e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA17333.1 - 6.8e-12 45.2 0.1 1e-05 25.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 ESA17333.1 - 1.5e-11 44.6 0.1 5.1e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17333.1 - 3.9e-09 36.7 0.7 2.8e-08 34.0 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA17333.1 - 3.7e-08 33.9 0.1 7.7e-07 29.6 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA17333.1 - 5e-08 32.3 0.1 1.2e-07 31.0 0.1 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA17333.1 - 1.8e-07 30.4 0.0 2.4e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA17333.1 - 8.2e-06 26.2 0.0 3.2e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA17333.1 - 0.00013 21.9 0.1 0.00022 21.2 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 ESA17333.1 - 0.00013 21.6 0.1 0.00027 20.6 0.1 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.7 ESA17333.1 - 0.00018 20.9 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA17333.1 - 0.0017 18.3 0.1 0.0058 16.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA17333.1 - 0.0038 16.6 0.0 0.016 14.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain CheR PF01739.13 ESA17333.1 - 0.012 14.9 0.2 0.087 12.1 0.1 2.0 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain N6_N4_Mtase PF01555.13 ESA17333.1 - 0.012 15.0 0.7 0.12 11.8 0.0 2.3 2 1 0 2 2 2 0 DNA methylase Methyltransf_9 PF08003.6 ESA17333.1 - 0.017 13.8 0.0 0.055 12.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Pox_MCEL PF03291.11 ESA17333.1 - 0.017 14.0 0.5 0.12 11.1 0.0 2.2 1 1 1 2 2 2 0 mRNA capping enzyme FCP1_C PF09309.5 ESA17333.1 - 0.023 14.0 0.2 0.028 13.7 0.1 1.1 1 0 0 1 1 1 0 FCP1, C-terminal PCMT PF01135.14 ESA17333.1 - 0.032 13.7 0.0 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 ESA17333.1 - 0.044 12.8 0.2 0.13 11.3 0.1 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase DOT1 PF08123.8 ESA17333.1 - 0.058 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_2 PF00891.13 ESA17333.1 - 0.081 12.1 0.0 0.092 11.9 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase TRAM_LAG1_CLN8 PF03798.11 ESA17335.1 - 3e-39 134.6 21.5 3e-39 134.6 14.9 1.4 2 0 0 2 2 2 1 TLC domain Isochorismatase PF00857.15 ESA17336.1 - 3.6e-25 88.8 0.3 1.2e-24 87.2 0.2 1.8 1 1 0 1 1 1 1 Isochorismatase family zf-ZPR1 PF03367.8 ESA17336.1 - 0.057 12.5 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain COX15-CtaA PF02628.10 ESA17337.1 - 3.8e-94 314.9 7.8 4.5e-94 314.6 5.4 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Ion_trans PF00520.26 ESA17338.1 - 0.0038 16.4 2.6 0.0049 16.1 1.8 1.2 1 0 0 1 1 1 1 Ion transport protein TRP PF06011.7 ESA17338.1 - 0.068 11.7 0.6 0.088 11.3 0.4 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Pox_A32 PF04665.7 ESA17341.1 - 4.1e-12 45.9 5.5 4.7e-09 35.9 0.1 3.0 3 0 0 3 3 3 2 Poxvirus A32 protein AAA_10 PF12846.2 ESA17341.1 - 0.004 16.6 0.1 2.4 7.5 0.0 2.9 3 0 0 3 3 3 1 AAA-like domain DUF641 PF04859.7 ESA17341.1 - 0.0084 15.8 1.7 0.025 14.3 1.2 1.8 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) AAA_22 PF13401.1 ESA17341.1 - 0.0089 16.1 0.0 0.032 14.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 ESA17341.1 - 0.024 15.1 2.6 0.22 11.9 0.0 3.3 3 0 0 3 3 3 0 Miro-like protein AAA_19 PF13245.1 ESA17341.1 - 0.026 14.2 0.2 0.053 13.2 0.1 1.4 1 0 0 1 1 1 0 Part of AAA domain NACHT PF05729.7 ESA17341.1 - 0.042 13.4 0.2 0.12 12.0 0.1 1.7 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.4 ESA17341.1 - 0.044 12.7 5.2 0.29 10.0 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.13 ESA17341.1 - 0.093 12.1 0.1 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family GvpK PF05121.7 ESA17341.1 - 0.25 11.1 3.4 0.43 10.4 1.3 2.2 1 1 1 2 2 2 0 Gas vesicle protein K CbiA PF01656.18 ESA17341.1 - 0.42 9.9 3.2 0.79 9.0 0.8 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Pox_A_type_inc PF04508.7 ESA17341.1 - 0.74 9.7 5.5 9.3 6.3 0.1 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Tropomyosin_1 PF12718.2 ESA17341.1 - 1.7 8.4 19.3 0.059 13.2 6.5 2.7 2 1 0 2 2 2 0 Tropomyosin like MACPF PF01823.14 ESA17342.1 - 1e-06 28.5 0.1 2.2e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 MAC/Perforin domain Asp PF00026.18 ESA17343.1 - 6.1e-86 288.5 0.4 7.5e-86 288.2 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 ESA17343.1 - 8.4e-07 29.4 0.6 0.007 16.8 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 ESA17343.1 - 2.5e-06 27.1 0.1 0.00021 20.8 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 ESA17343.1 - 3.2e-06 27.2 0.0 6.7e-05 22.8 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Pkinase_Tyr PF07714.12 ESA17344.1 - 6.9e-43 146.5 0.0 9.2e-43 146.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17344.1 - 5e-37 127.4 0.0 2.5e-36 125.1 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain DUF438 PF04282.8 ESA17344.1 - 0.015 15.0 0.9 0.043 13.5 0.3 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF438) Pkinase_Tyr PF07714.12 ESA17347.1 - 1.8e-47 161.5 0.0 2.5e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17347.1 - 5.9e-44 150.1 0.4 8.6e-44 149.6 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA17347.1 - 0.042 13.5 0.1 0.068 12.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family FYVE_2 PF02318.11 ESA17347.1 - 7.3 6.5 16.2 0.94 9.3 6.4 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger BTB PF00651.26 ESA17349.1 - 1.3e-10 41.2 0.1 2.7e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA17349.1 - 3.9e-08 33.3 2.5 3.9e-08 33.3 1.7 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA17349.1 - 2.6e-07 30.4 1.6 1.9e-05 24.4 0.1 3.7 2 1 2 4 4 4 1 BTB And C-terminal Kelch Abhydrolase_3 PF07859.8 ESA17350.1 - 1.4e-37 129.3 0.0 1.7e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA17350.1 - 1.1e-07 30.8 0.0 1.7e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) CTV_P33 PF07184.6 ESA17350.1 - 0.00073 18.4 0.1 0.0018 17.2 0.1 1.6 2 0 0 2 2 2 1 Citrus tristeza virus P33 protein Lipase_3 PF01764.20 ESA17350.1 - 0.0032 17.0 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Peptidase_S9 PF00326.16 ESA17350.1 - 0.0034 16.6 0.0 0.02 14.1 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.6 ESA17350.1 - 0.011 15.4 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.2 ESA17350.1 - 0.029 14.1 0.0 0.038 13.7 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.15 ESA17350.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Myb_DNA-binding PF00249.26 ESA17353.1 - 6.3e-07 29.3 0.0 1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA17353.1 - 0.091 12.8 0.1 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pkinase_Tyr PF07714.12 ESA17354.1 - 4.7e-36 124.1 0.0 6.9e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17354.1 - 4.8e-34 117.6 0.0 9.2e-34 116.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain OrfB_Zn_ribbon PF07282.6 ESA17354.1 - 0.0075 15.8 0.5 0.021 14.5 0.3 1.7 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Prok-RING_1 PF14446.1 ESA17354.1 - 0.0087 15.7 0.2 0.018 14.7 0.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 DUF1679 PF07914.6 ESA17354.1 - 0.0097 14.5 0.1 0.016 13.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Sds3 PF08598.6 ESA17354.1 - 0.14 11.6 0.7 0.27 10.7 0.5 1.4 1 0 0 1 1 1 0 Sds3-like Pkinase PF00069.20 ESA17355.1 - 3e-25 88.8 0.0 3.3e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17355.1 - 1.6e-24 86.4 0.0 1.7e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA17355.1 - 0.017 14.0 0.0 0.031 13.2 0.0 1.5 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 ESA17355.1 - 0.081 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Dimer_Tnp_hAT PF05699.9 ESA17356.1 - 8.4e-16 57.3 0.1 9.6e-16 57.1 0.1 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Dimer_Tnp_hAT PF05699.9 ESA17357.1 - 4.8e-17 61.3 0.1 5.1e-17 61.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Exo_endo_phos_2 PF14529.1 ESA17361.1 - 0.0001 21.9 0.1 0.00011 21.7 0.1 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA17361.1 - 0.019 14.9 0.1 0.022 14.6 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ribosomal_60s PF00428.14 ESA17363.1 - 1.9e-24 85.8 7.9 2.2e-24 85.6 5.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Peptidase_M24 PF00557.19 ESA17364.1 - 3.5e-46 157.4 0.3 4.4e-46 157.0 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 NST1 PF13945.1 ESA17364.1 - 0.19 11.7 11.1 0.06 13.4 5.6 1.6 1 1 1 2 2 2 0 Salt tolerance down-regulator Cnd2 PF05786.9 ESA17364.1 - 0.63 8.4 9.6 0.92 7.9 6.6 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 CDC45 PF02724.9 ESA17364.1 - 1.3 7.0 6.9 1.8 6.5 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein UEV PF05743.8 ESA17365.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 UEV domain Mago_nashi PF02792.9 ESA17366.1 - 2.1e-81 270.6 0.7 2.4e-81 270.4 0.5 1.0 1 0 0 1 1 1 1 Mago nashi protein UPF0240 PF06784.6 ESA17367.1 - 0.079 12.6 0.2 0.13 11.9 0.1 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0240) nsp9 PF08710.5 ESA17368.1 - 0.17 12.0 1.9 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 nsp9 replicase zf-C3HC4_2 PF13923.1 ESA17370.1 - 5.5e-07 29.5 10.0 7.2e-07 29.1 7.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA17370.1 - 3.3e-06 26.6 9.7 4.2e-06 26.3 6.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA17370.1 - 1.5e-05 24.5 8.5 1.8e-05 24.3 5.9 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA17370.1 - 1.7e-05 24.5 8.2 2.2e-05 24.1 5.7 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESA17370.1 - 0.00051 19.6 9.3 0.00088 18.9 6.4 1.4 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA17370.1 - 0.0065 16.1 6.1 0.011 15.4 4.1 1.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA17370.1 - 0.016 15.0 8.9 0.029 14.2 6.2 1.5 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 ESA17370.1 - 0.034 13.6 1.9 0.034 13.6 1.3 1.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 ESA17370.1 - 0.55 10.0 5.8 0.83 9.4 4.0 1.4 1 1 0 1 1 1 0 zf-RING of BARD1-type protein Pantoate_ligase PF02569.10 ESA17371.1 - 4.5e-96 320.9 0.0 5.2e-96 320.6 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Cellulase-like PF12876.2 ESA17372.1 - 0.00029 21.2 0.1 0.0013 19.1 0.0 2.0 2 0 0 2 2 2 1 Sugar-binding cellulase-like DUF1691 PF07950.6 ESA17372.1 - 0.027 14.4 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) Sec3-PIP2_bind PF15277.1 ESA17372.1 - 0.052 13.4 0.3 2.4 8.0 0.0 2.9 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH zf-C2H2 PF00096.21 ESA17373.1 - 0.23 11.8 5.0 0.41 11.0 1.7 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ion_trans PF00520.26 ESA17374.1 - 0.058 12.6 8.3 0.093 11.9 5.8 1.3 1 0 0 1 1 1 0 Ion transport protein DDHD PF02862.12 ESA17375.1 - 0.022 14.5 4.8 0.04 13.7 3.3 1.4 1 0 0 1 1 1 0 DDHD domain GvpL_GvpF PF06386.6 ESA17375.1 - 0.14 11.6 9.5 1.7 8.1 2.3 2.3 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF PEX11 PF05648.9 ESA17375.1 - 0.25 10.5 4.1 0.24 10.6 0.2 2.4 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Prismane PF03063.15 ESA17375.1 - 1.2 7.4 9.1 54 1.9 6.3 2.0 1 1 0 1 1 1 0 Prismane/CO dehydrogenase family Adeno_E4 PF05385.6 ESA17375.1 - 3.6 7.5 8.6 3 7.8 4.1 2.2 1 1 1 2 2 2 0 Mastadenovirus early E4 13 kDa protein Pkinase PF00069.20 ESA17376.1 - 1.9e-19 69.8 0.0 2.1e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17376.1 - 6.1e-17 61.5 0.0 6.6e-17 61.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA17376.1 - 0.0016 17.8 0.2 0.0019 17.6 0.1 1.1 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA17376.1 - 0.0019 17.4 0.1 0.0019 17.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA17376.1 - 0.0033 16.5 0.1 0.0037 16.3 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA17376.1 - 0.016 14.1 0.0 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA17376.1 - 0.043 13.5 0.2 0.057 13.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA17376.1 - 0.099 11.9 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL MACPF PF01823.14 ESA17377.1 - 0.035 13.7 0.0 0.037 13.7 0.0 1.1 1 0 0 1 1 1 0 MAC/Perforin domain MACPF PF01823.14 ESA17378.1 - 1.7e-05 24.6 5.5 1.7e-05 24.6 3.8 2.9 2 1 2 4 4 4 1 MAC/Perforin domain Retrotrans_gag PF03732.12 ESA17380.1 - 0.09 12.8 0.4 0.16 12.0 0.3 1.4 1 0 0 1 1 1 0 Retrotransposon gag protein Lyase_1 PF00206.15 ESA17380.1 - 0.098 11.8 0.1 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Lyase DUF2025 PF09634.5 ESA17384.1 - 0.088 12.5 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2025) NtA PF03146.10 ESA17384.1 - 0.13 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Agrin NtA domain MMR_HSR1 PF01926.18 ESA17385.1 - 2.5e-06 27.4 0.3 2.5e-06 27.4 0.2 2.8 4 0 0 4 4 4 1 50S ribosome-binding GTPase SRP54 PF00448.17 ESA17385.1 - 8e-05 22.1 0.6 0.00029 20.3 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Filament PF00038.16 ESA17385.1 - 0.00048 19.6 4.0 0.00048 19.6 2.8 2.8 3 0 0 3 3 3 1 Intermediate filament protein AAA_28 PF13521.1 ESA17385.1 - 0.003 17.5 0.0 0.04 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA17385.1 - 0.0048 16.0 1.4 0.017 14.3 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 ESA17385.1 - 0.01 15.3 0.8 0.32 10.4 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family HisKA_3 PF07730.8 ESA17385.1 - 0.013 15.7 0.3 6.4 7.2 0.0 3.7 3 1 0 3 3 3 0 Histidine kinase CHDCT2 PF08074.6 ESA17385.1 - 0.017 14.8 1.1 0.66 9.6 0.1 2.5 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain AAA_29 PF13555.1 ESA17385.1 - 0.018 14.5 0.2 0.042 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 ESA17385.1 - 0.03 14.6 0.0 0.03 14.6 0.0 3.8 4 0 0 4 4 4 0 ABC transporter AAA PF00004.24 ESA17385.1 - 0.042 14.0 1.0 0.14 12.3 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESA17385.1 - 0.082 12.6 0.1 0.22 11.3 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain GCN5L1 PF06320.8 ESA17385.1 - 0.56 10.0 11.5 0.28 11.0 2.2 2.9 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) BLOC1_2 PF10046.4 ESA17385.1 - 8.1 6.6 22.2 0.04 14.0 1.7 3.6 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BTB PF00651.26 ESA17387.1 - 6.5e-16 58.3 2.6 1.2e-15 57.4 1.8 1.5 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA17387.1 - 1.7e-05 24.9 0.3 3.6e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 SPRY domain Utp13 PF08625.6 ESA17387.1 - 0.0067 16.0 0.3 0.024 14.2 0.2 2.0 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain RB_A PF01858.12 ESA17387.1 - 0.062 12.9 1.2 0.51 9.9 0.0 2.4 2 1 0 2 2 2 0 Retinoblastoma-associated protein A domain BTB PF00651.26 ESA17388.1 - 4e-13 49.3 3.0 6.6e-13 48.6 2.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA17388.1 - 2.4e-08 34.1 0.8 4.2e-08 33.3 0.5 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA17389.1 - 0.00019 21.3 0.1 0.00024 21.0 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain RB_A PF01858.12 ESA17389.1 - 0.0012 18.5 0.3 0.0014 18.3 0.2 1.0 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain DUF2178 PF09946.4 ESA17389.1 - 0.048 13.3 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) Dimer_Tnp_hAT PF05699.9 ESA17392.1 - 1e-11 44.3 0.0 1.1e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Toxin_8 PF07365.7 ESA17392.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Alpha conotoxin precursor RRM_1 PF00076.17 ESA17395.1 - 3.6e-20 71.3 0.0 5e-20 70.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA17395.1 - 6.4e-13 48.4 0.0 8.9e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA17395.1 - 2.1e-10 40.2 0.0 3.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF566 PF04484.7 ESA17395.1 - 0.91 8.9 6.3 1.1 8.7 4.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) RXT2_N PF08595.6 ESA17396.1 - 1.7e-14 53.8 1.0 1.7e-14 53.8 0.7 3.4 2 1 0 2 2 2 1 RXT2-like, N-terminal RST PF12174.3 ESA17398.1 - 0.36 10.6 4.2 7.9 6.3 0.1 3.3 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain WD40 PF00400.27 ESA17399.1 - 2.7e-06 27.0 0.0 0.0029 17.4 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Big_5 PF13205.1 ESA17400.1 - 0.00037 21.0 1.5 0.001 19.6 1.0 1.8 1 0 0 1 1 1 1 Bacterial Ig-like domain Acyltransferase PF01553.16 ESA17401.1 - 5.3e-25 87.3 0.0 9e-25 86.6 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase YabP PF07873.6 ESA17402.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 YabP family zf-H2C2_2 PF13465.1 ESA17403.1 - 7.7e-11 41.7 17.0 6.7e-07 29.2 2.6 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 ESA17403.1 - 1.1e-08 34.9 13.2 0.00062 19.9 1.6 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA17403.1 - 2.1e-05 24.5 12.0 0.0082 16.4 1.0 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA17403.1 - 0.23 11.3 4.1 3.2 7.7 0.2 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Piwi PF02171.12 ESA17404.1 - 3.2e-80 269.3 0.0 4.8e-80 268.7 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA17404.1 - 4.3e-11 42.2 0.1 7.4e-11 41.4 0.1 1.4 1 0 0 1 1 1 1 PAZ domain Gon7 PF08738.5 ESA17405.1 - 8.4e-05 22.5 7.3 0.0006 19.7 5.0 1.9 1 1 0 1 1 1 1 Gon7 family DUF4611 PF15387.1 ESA17405.1 - 0.0011 19.0 5.5 0.0014 18.6 3.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) DUF1521 PF07481.6 ESA17405.1 - 0.067 12.8 6.5 0.17 11.5 4.5 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1521) Utp11 PF03998.8 ESA17405.1 - 0.8 9.4 6.1 1 9.1 4.2 1.2 1 0 0 1 1 1 0 Utp11 protein NOA36 PF06524.7 ESA17405.1 - 6.5 5.9 8.2 7.2 5.7 5.7 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4061 PF13270.1 ESA17405.1 - 8 6.6 7.0 0.27 11.3 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) DUF2184 PF09950.4 ESA17407.1 - 0.075 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2184) Drf_FH1 PF06346.7 ESA17408.1 - 4.1e-05 23.1 19.8 5.5e-05 22.7 13.7 1.2 1 0 0 1 1 1 1 Formin Homology Region 1 UCH PF00443.24 ESA17409.1 - 8.9e-44 149.6 1.3 1.1e-43 149.2 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA17409.1 - 6.7e-30 104.5 0.0 8.4e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 ESA17409.1 - 3e-09 37.1 0.3 1.4e-07 31.7 0.2 2.7 1 1 0 1 1 1 1 MATH domain BCS1_N PF08740.6 ESA17410.1 - 1.3e-05 24.9 0.1 0.16 11.5 0.1 3.5 3 0 0 3 3 3 2 BCS1 N terminal DUF3279 PF11682.3 ESA17410.1 - 0.00017 21.1 14.2 0.037 13.6 1.0 3.9 3 0 0 3 3 3 3 Protein of unknown function (DUF3279) zf-ribbon_3 PF13248.1 ESA17410.1 - 7.3 5.9 17.0 0.41 9.9 0.4 3.9 4 0 0 4 4 4 0 zinc-ribbon domain TPX2_importin PF12214.3 ESA17412.1 - 0.054 13.5 13.3 0.16 12.0 0.4 2.8 3 0 0 3 3 3 0 Cell cycle regulated microtubule associated protein BBIP10 PF14777.1 ESA17412.1 - 0.36 10.2 2.1 1.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Cilia BBSome complex subunit 10 BTB PF00651.26 ESA17415.1 - 4.1e-18 65.3 0.2 1.3e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA17415.1 - 1.5e-08 34.7 2.7 1.5e-08 34.7 1.9 2.0 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA17415.1 - 0.011 15.5 5.2 0.013 15.3 0.6 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF1199 PF06712.6 ESA17415.1 - 0.12 12.1 0.1 0.41 10.4 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1199) Asp_protease PF09668.5 ESA17416.1 - 2.6e-19 69.0 0.2 5.6e-19 67.9 0.1 1.6 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.18 ESA17416.1 - 5.5e-10 38.4 0.3 1e-09 37.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 ESA17416.1 - 1.1e-05 25.5 0.1 2.8e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 ESA17416.1 - 0.003 17.1 0.6 0.0065 16.1 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Asp_protease_2 PF13650.1 ESA17416.1 - 0.0055 17.1 0.0 0.019 15.4 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease RVP PF00077.15 ESA17416.1 - 0.0088 15.9 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA17416.1 - 0.031 14.0 0.0 0.067 13.0 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF964 PF06133.6 ESA17416.1 - 0.24 11.4 4.9 0.12 12.4 1.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF964) YgaB PF14182.1 ESA17416.1 - 3.4 7.9 12.3 2.6 8.3 0.9 3.3 3 1 0 3 3 3 0 YgaB-like protein UBA PF00627.26 ESA17417.1 - 3e-05 23.7 0.0 4.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 ESA17417.1 - 0.00017 21.0 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 UBA-like domain HSBP1 PF06825.7 ESA17417.1 - 0.038 13.5 0.1 0.079 12.5 0.0 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 DGF-1_C PF11040.3 ESA17417.1 - 0.18 11.7 0.9 0.72 9.7 0.6 1.9 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus zf-RVT PF13966.1 ESA17420.1 - 0.00033 20.9 0.5 0.00063 20.0 0.3 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Pneumo_att_G PF05539.6 ESA17422.1 - 0.17 11.2 2.9 0.19 11.0 2.0 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Nucleoplasmin PF03066.10 ESA17424.1 - 1.1 8.7 5.7 1.1 8.7 3.9 1.1 1 0 0 1 1 1 0 Nucleoplasmin DUF3295 PF11702.3 ESA17424.1 - 3 6.7 5.4 2.5 6.9 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Ceramidase PF05875.7 ESA17425.1 - 1.4e-83 280.0 15.9 1.6e-83 279.8 11.0 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.6 ESA17425.1 - 6.5 6.6 10.0 0.3 10.8 2.0 2.5 2 0 0 2 2 2 0 Trp-operon Leader Peptide Cag12 PF13117.1 ESA17426.1 - 0.058 13.3 0.1 0.091 12.6 0.1 1.3 1 0 0 1 1 1 0 Cag pathogenicity island protein Cag12 PAP2 PF01569.16 ESA17426.1 - 0.084 12.5 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 PAP2 superfamily Neurochondrin PF05536.6 ESA17427.1 - 0.021 13.1 0.2 0.15 10.3 0.1 1.8 1 1 1 2 2 2 0 Neurochondrin RabGAP-TBC PF00566.13 ESA17429.1 - 6.2e-46 156.5 0.3 1.6e-45 155.1 0.2 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.15 ESA17429.1 - 4.2e-10 39.0 0.1 8.9e-10 37.9 0.0 1.6 1 0 0 1 1 1 1 GRAM domain EF-hand_7 PF13499.1 ESA17429.1 - 0.00036 20.5 2.9 0.014 15.4 1.0 3.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 ESA17429.1 - 0.0066 16.2 3.1 3.9 7.6 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain Arb1 PF09692.5 ESA17430.1 - 8.6e-40 136.7 0.8 5.4e-28 97.9 0.2 2.9 1 1 1 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Nbl1_Borealin_N PF10444.4 ESA17432.1 - 8.9e-12 44.1 5.3 1.4e-11 43.5 3.7 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal DUF2031 PF09592.5 ESA17432.1 - 0.0075 15.4 2.1 0.0077 15.3 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2031) LsmAD PF06741.8 ESA17432.1 - 0.045 13.8 0.4 0.096 12.7 0.2 1.6 1 0 0 1 1 1 0 LsmAD domain ApoLp-III PF07464.6 ESA17432.1 - 0.054 13.5 1.2 0.099 12.6 0.3 1.6 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) AKNA PF12443.3 ESA17432.1 - 0.22 11.5 2.5 0.21 11.6 0.6 1.7 2 0 0 2 2 2 0 AT-hook-containing transcription factor TPR_11 PF13414.1 ESA17433.1 - 3.1e-24 84.3 24.6 6.3e-08 32.1 0.6 6.2 3 1 2 6 6 6 5 TPR repeat TPR_2 PF07719.12 ESA17433.1 - 4.7e-19 66.6 21.8 0.00061 19.5 0.5 8.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.23 ESA17433.1 - 2.6e-14 52.1 38.7 0.0041 16.6 0.2 8.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17433.1 - 3.5e-12 46.0 8.0 0.0033 17.3 0.1 5.4 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17433.1 - 4.3e-10 38.9 19.4 0.0062 16.6 0.1 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA17433.1 - 1e-09 38.4 24.3 6.4e-05 23.0 1.6 4.8 2 1 3 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA17433.1 - 2.8e-09 37.1 1.2 0.029 14.7 0.0 5.2 3 2 4 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESA17433.1 - 6.9e-08 32.2 0.0 0.035 13.9 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17433.1 - 2.9e-07 30.9 0.0 1.6 9.4 0.0 4.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17433.1 - 3.1e-07 30.4 0.0 2 9.2 0.0 5.4 2 2 4 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17433.1 - 1e-05 24.9 40.3 0.0073 16.0 0.4 8.4 6 2 3 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17433.1 - 0.00014 21.3 7.0 1 9.3 0.0 5.9 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA17433.1 - 0.00092 19.5 4.0 43 4.8 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA17433.1 - 0.0087 15.8 4.2 0.16 11.8 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA17433.1 - 0.011 14.9 0.0 0.22 10.8 0.0 2.8 2 0 0 2 2 2 0 SHNi-TPR Fis1_TPR_C PF14853.1 ESA17433.1 - 0.53 10.1 20.0 1.1 9.1 0.3 5.8 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.7 ESA17434.1 - 2.7e-57 189.9 4.3 1.1e-12 48.0 0.0 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_11 PF13414.1 ESA17434.1 - 0.00061 19.3 13.1 0.76 9.4 0.4 4.2 2 1 2 4 4 4 3 TPR repeat TPR_6 PF13174.1 ESA17434.1 - 0.0025 18.1 0.8 11 6.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.7 ESA17434.1 - 0.023 14.4 1.8 1.7 8.5 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17434.1 - 0.28 11.4 16.1 1.2 9.5 0.2 5.9 4 1 3 7 7 7 0 Tetratricopeptide repeat MIT PF04212.13 ESA17434.1 - 0.73 9.7 8.8 11 5.9 0.1 4.7 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain DUF3053 PF11254.3 ESA17435.1 - 0.012 14.8 0.2 0.014 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) TPR_MLP1_2 PF07926.7 ESA17435.1 - 0.045 13.5 1.2 0.061 13.0 0.8 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein R3H-assoc PF13902.1 ESA17436.1 - 0.012 15.5 0.6 0.014 15.3 0.4 1.1 1 0 0 1 1 1 0 R3H-associated N-terminal domain Hom_end_hint PF05203.11 ESA17436.1 - 0.14 11.9 0.1 0.15 11.7 0.1 1.0 1 0 0 1 1 1 0 Hom_end-associated Hint ACT_4 PF13291.1 ESA17436.1 - 0.15 12.4 3.4 0.22 11.8 2.4 1.3 1 0 0 1 1 1 0 ACT domain SLS PF14611.1 ESA17437.1 - 0.0092 15.4 0.6 0.011 15.1 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator WBS_methylT PF12589.3 ESA17437.1 - 0.026 15.0 0.3 0.033 14.6 0.2 1.1 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome FlaC_arch PF05377.6 ESA17437.1 - 0.16 11.9 1.6 0.29 11.0 1.1 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) LsmAD PF06741.8 ESA17437.1 - 1.3 9.1 4.2 3.3 7.8 2.9 1.7 1 1 0 1 1 1 0 LsmAD domain HEAT_2 PF13646.1 ESA17440.1 - 3.3e-06 27.2 0.6 0.0019 18.4 0.0 1.8 1 1 1 2 2 2 2 HEAT repeats V-ATPase_H_N PF03224.9 ESA17440.1 - 0.0069 15.5 0.3 0.0096 15.0 0.2 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 ESA17440.1 - 0.008 16.0 0.9 0.45 10.4 0.0 2.6 1 1 1 2 2 2 1 V-ATPase subunit H Atx10homo_assoc PF09759.4 ESA17440.1 - 0.031 13.9 0.2 0.1 12.3 0.1 1.9 1 1 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain DUF4259 PF14078.1 ESA17440.1 - 0.088 13.3 1.0 6.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) DNA_pol_B_palm PF14792.1 ESA17441.1 - 1.6e-31 108.6 0.0 4.7e-31 107.1 0.0 1.9 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.1 ESA17441.1 - 7.6e-20 70.8 1.0 7.3e-19 67.7 0.5 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 ESA17441.1 - 1.1e-17 63.3 0.3 9.9e-17 60.2 0.1 2.5 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.1 ESA17441.1 - 4.4e-15 55.1 0.0 1.3e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_5 PF14520.1 ESA17441.1 - 0.0023 18.0 0.1 0.13 12.4 0.1 2.7 1 1 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.18 ESA17441.1 - 0.0041 16.7 0.2 0.0041 16.7 0.2 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif Sel1 PF08238.7 ESA17442.1 - 1.1e-52 175.2 59.8 7.8e-12 45.4 0.9 10.5 10 2 0 10 10 10 8 Sel1 repeat TPR_20 PF14561.1 ESA17442.1 - 0.013 15.5 7.6 5.8 7.1 0.5 4.9 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17442.1 - 0.96 9.8 26.9 5.2 7.5 0.4 8.6 6 3 2 8 8 8 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA17442.1 - 3.7 7.3 9.4 6.5 6.5 0.0 4.3 4 1 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_6 PF13174.1 ESA17442.1 - 5.5 7.6 18.0 9.9 6.8 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA17444.1 - 5.1e-06 25.7 0.1 6.5e-05 22.1 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17444.1 - 0.0014 17.8 0.0 0.0026 16.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain zf-C2H2_4 PF13894.1 ESA17445.1 - 7.6e-05 22.7 9.8 0.0051 17.0 0.5 2.9 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA17445.1 - 0.0034 17.6 15.6 0.12 12.7 2.1 3.2 3 1 0 3 3 3 2 Zinc finger, C2H2 type Neuropeptide_S PF14993.1 ESA17445.1 - 0.079 12.6 0.5 0.26 10.9 0.2 1.9 2 0 0 2 2 2 0 Neuropeptide S precursor protein zf-Tim10_DDP PF02953.10 ESA17445.1 - 1.6 8.0 6.9 5.6 6.3 0.2 2.3 2 0 0 2 2 2 0 Tim10/DDP family zinc finger MFS_1 PF07690.11 ESA17446.1 - 8e-52 176.0 19.3 8e-52 176.0 13.4 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA17446.1 - 2e-07 29.9 12.7 2e-07 29.9 8.8 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter B12D PF06522.6 ESA17447.1 - 0.0022 17.6 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Con-6 PF10346.4 ESA17447.1 - 0.083 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Conidiation protein 6 Kelch_6 PF13964.1 ESA17448.1 - 1.4e-24 85.1 22.3 0.0018 18.3 0.0 11.0 9 2 2 11 11 11 7 Kelch motif Kelch_5 PF13854.1 ESA17448.1 - 7.5e-23 80.0 4.5 0.086 12.8 0.0 9.2 8 0 0 8 8 8 7 Kelch motif Kelch_4 PF13418.1 ESA17448.1 - 9.8e-23 79.6 17.0 0.0048 16.6 0.0 9.6 9 0 0 9 9 9 6 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA17448.1 - 7.7e-22 76.5 14.2 0.00067 19.1 0.0 11.2 11 1 0 11 11 11 6 Kelch motif Kelch_2 PF07646.10 ESA17448.1 - 5.1e-16 57.7 3.4 0.15 11.8 0.0 9.6 10 0 0 10 10 10 4 Kelch motif Kelch_3 PF13415.1 ESA17448.1 - 1.8e-15 56.6 17.9 0.0078 16.3 0.0 10.3 12 0 0 12 12 12 4 Galactose oxidase, central domain YrhC PF14143.1 ESA17448.1 - 0.044 13.7 0.2 7.3 6.6 0.0 2.6 2 0 0 2 2 2 0 YrhC-like protein RCC1_2 PF13540.1 ESA17448.1 - 0.066 12.8 0.2 31 4.3 0.0 3.5 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Secretin PF00263.16 ESA17448.1 - 0.18 11.2 7.8 3.7 6.9 0.0 4.8 5 1 0 5 5 5 0 Bacterial type II and III secretion system protein Fez1 PF06818.10 ESA17450.1 - 0.012 15.6 0.1 0.012 15.6 0.1 1.1 1 0 0 1 1 1 0 Fez1 CENP-F_leu_zip PF10473.4 ESA17451.1 - 0.011 15.6 5.0 0.013 15.3 3.5 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.12 ESA17451.1 - 0.019 14.5 0.5 0.019 14.5 0.3 1.7 2 0 0 2 2 2 0 Prefoldin subunit KLRAQ PF10205.4 ESA17451.1 - 0.04 13.9 5.6 1 9.4 0.4 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF4472 PF14739.1 ESA17451.1 - 0.53 10.7 7.9 4.1 7.8 5.5 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4472) DUF1027 PF06265.6 ESA17451.1 - 0.82 9.5 5.5 0.48 10.3 1.8 2.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1027) DUF972 PF06156.8 ESA17451.1 - 2.1 8.7 9.7 15 5.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF3166 PF11365.3 ESA17451.1 - 2.2 8.7 5.5 1 9.8 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) IncA PF04156.9 ESA17451.1 - 2.8 7.4 8.4 16 4.9 5.9 1.9 1 1 0 1 1 1 0 IncA protein zf-C4H2 PF10146.4 ESA17451.1 - 9.4 6.1 7.4 12 5.8 5.2 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein HSP70 PF00012.15 ESA17453.1 - 8.2e-07 27.3 0.1 2.3e-05 22.5 0.1 2.5 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA17453.1 - 0.00015 20.5 0.0 0.0054 15.3 0.0 2.2 1 1 1 2 2 2 2 MreB/Mbl protein Sel1 PF08238.7 ESA17454.1 - 2e-141 457.3 73.7 2.1e-11 44.0 1.0 16.0 16 0 0 16 16 16 16 Sel1 repeat TPR_6 PF13174.1 ESA17454.1 - 1.2e-06 28.6 40.6 0.19 12.2 0.5 12.2 14 0 0 14 14 14 4 Tetratricopeptide repeat Msg2_C PF12373.3 ESA17454.1 - 0.0098 15.0 0.3 2.9 7.1 0.0 3.2 3 0 0 3 3 3 2 Major surface glycoprotein 2 C terminal TPR_16 PF13432.1 ESA17454.1 - 0.03 14.9 16.8 9.1 7.0 0.3 8.0 5 3 4 10 10 10 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA17454.1 - 0.6 10.2 6.6 3.9 7.6 0.8 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA17455.1 - 1.4e-175 565.9 84.7 1.4e-11 44.6 0.3 21.5 21 1 0 21 21 21 21 Sel1 repeat TPR_6 PF13174.1 ESA17455.1 - 0.00067 19.9 40.9 1.5 9.4 0.0 13.9 16 1 0 16 16 16 3 Tetratricopeptide repeat TPR_10 PF13374.1 ESA17455.1 - 0.26 11.3 5.3 6.2 6.9 0.1 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA17456.1 - 1.1e-127 413.6 52.9 5.6e-12 45.8 0.1 16.0 16 0 0 16 16 16 14 Sel1 repeat TPR_6 PF13174.1 ESA17456.1 - 9.1e-14 50.8 27.2 1.1 9.8 0.0 13.4 12 2 2 14 14 14 5 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17456.1 - 0.00025 21.6 10.0 61 4.4 0.0 8.2 8 1 1 9 9 9 0 Tetratricopeptide repeat Peptidase_M73 PF12389.3 ESA17456.1 - 0.086 12.2 3.6 4.7 6.6 0.1 2.5 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase TPR_19 PF14559.1 ESA17456.1 - 1.1 9.7 20.2 13 6.1 0.0 8.8 11 1 0 11 11 11 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17456.1 - 4.9 7.1 34.6 1.8 8.5 0.2 9.4 4 3 6 10 10 10 0 Tetratricopeptide repeat HTH_Tnp_IS630 PF01710.11 ESA17457.1 - 0.008 15.8 3.2 0.012 15.3 1.5 1.7 1 1 0 1 1 1 1 Transposase DUF3799 PF12684.2 ESA17457.1 - 0.022 14.1 1.5 0.032 13.5 0.5 1.5 2 0 0 2 2 2 0 PDDEXK-like domain of unknown function (DUF3799) DUF1743 PF08489.6 ESA17457.1 - 0.19 11.4 1.0 0.25 11.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1743) Amino_oxidase PF01593.19 ESA17459.1 - 6.3e-36 124.4 0.0 3e-35 122.1 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Kunitz_BPTI PF00014.18 ESA17459.1 - 0.0064 16.6 2.6 0.011 15.9 0.6 2.2 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain MEDS PF14417.1 ESA17459.1 - 0.018 14.1 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain NAD_binding_8 PF13450.1 ESA17459.1 - 0.14 12.1 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain RTC4 PF14474.1 ESA17460.1 - 6e-05 22.9 0.0 0.00013 21.8 0.0 1.4 1 1 0 1 1 1 1 RTC4-like domain Bromodomain PF00439.20 ESA17462.1 - 3.4e-18 65.3 0.2 3.9e-18 65.1 0.1 1.0 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.20 ESA17463.1 - 1.4e-17 63.3 0.1 1.5e-17 63.2 0.1 1.0 1 0 0 1 1 1 1 Bromodomain LRR_4 PF12799.2 ESA17463.1 - 0.052 13.1 0.4 0.077 12.6 0.3 1.3 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) CobT PF06213.7 ESA17465.1 - 0.18 10.8 8.7 0.26 10.3 6.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT zf-C2H2 PF00096.21 ESA17465.1 - 0.23 11.8 6.3 0.79 10.1 4.4 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type GEMIN8 PF15348.1 ESA17465.1 - 0.33 10.9 9.0 0.62 10.0 6.2 1.4 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 CENP-B_dimeris PF09026.5 ESA17465.1 - 0.37 11.0 8.6 0.81 9.9 6.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF1616 PF07760.6 ESA17466.1 - 0.064 12.3 0.2 0.081 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Peptidase_S41 PF03572.13 ESA17467.1 - 5.5e-06 25.8 0.0 1.3e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Peptidase family S41 Beta-lactamase PF00144.19 ESA17468.1 - 7.2e-40 137.0 0.0 2.1e-39 135.5 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase DUF1827 PF08860.5 ESA17469.1 - 0.0079 16.2 0.7 0.02 15.0 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1827) KilA-N PF04383.8 ESA17469.1 - 0.028 14.0 4.7 0.048 13.2 0.5 2.5 3 0 0 3 3 3 0 KilA-N domain KIP1 PF07765.7 ESA17469.1 - 0.043 13.6 0.3 0.12 12.1 0.2 1.8 1 0 0 1 1 1 0 KIP1-like protein DUF3901 PF13040.1 ESA17469.1 - 1.2 8.4 9.1 0.12 11.7 2.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3901) Pkinase_Tyr PF07714.12 ESA17471.1 - 9.6e-51 172.3 0.1 2.1e-50 171.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17471.1 - 6.4e-44 150.0 0.5 1.4e-43 148.8 0.4 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA17472.1 - 6.9e-19 67.9 0.7 9.6e-19 67.5 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17472.1 - 9.3e-19 67.5 0.0 1.4e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA17472.1 - 0.013 14.5 0.2 0.019 14.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YchF-GTPase_C PF06071.8 ESA17472.1 - 0.026 14.2 0.2 0.091 12.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF933) APH PF01636.18 ESA17472.1 - 0.058 13.1 0.4 0.17 11.5 0.4 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA17473.1 - 7.6e-86 280.6 40.0 2.8e-11 43.6 0.1 10.0 10 0 0 10 10 10 10 Sel1 repeat TPR_6 PF13174.1 ESA17473.1 - 2.9e-05 24.2 19.5 1.8 9.2 0.1 7.9 9 1 0 9 9 9 3 Tetratricopeptide repeat AAA_27 PF13514.1 ESA17474.1 - 0.028 12.1 1.7 0.029 12.0 1.2 1.0 1 0 0 1 1 1 0 AAA domain Gal4_dimer PF03902.8 ESA17474.1 - 0.27 11.2 1.5 0.32 10.9 0.4 1.6 2 0 0 2 2 2 0 Gal4-like dimerisation domain Peptidase_S41 PF03572.13 ESA17475.1 - 2.5e-07 30.2 0.0 1.2e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 Peptidase family S41 DBD_Tnp_Mut PF03108.10 ESA17476.1 - 0.0013 18.2 0.5 0.0035 16.8 0.3 1.7 1 1 0 1 1 1 1 MuDR family transposase DctQ PF04290.7 ESA17477.1 - 0.077 12.7 0.6 0.1 12.3 0.4 1.2 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component CsbD PF05532.7 ESA17481.1 - 3.4e-05 23.4 1.2 7.9e-05 22.2 0.8 1.6 1 0 0 1 1 1 1 CsbD-like Pkinase PF00069.20 ESA17484.1 - 7.5e-19 67.8 0.6 1.6e-18 66.7 0.4 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17484.1 - 1.4e-18 66.9 0.0 1.6e-18 66.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase CLTH PF10607.4 ESA17484.1 - 0.045 13.4 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Kdo PF06293.9 ESA17484.1 - 0.073 12.1 0.1 0.097 11.7 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA17485.1 - 2.7e-31 108.6 0.0 4.9e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17485.1 - 5.7e-30 104.2 0.0 9.2e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.26 ESA17485.1 - 0.037 14.0 0.2 0.27 11.3 0.0 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain APH PF01636.18 ESA17485.1 - 0.057 13.1 0.2 0.097 12.3 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nucleoside_tran PF01733.13 ESA17486.1 - 0.069 12.3 0.0 0.078 12.1 0.0 1.0 1 0 0 1 1 1 0 Nucleoside transporter Pkinase PF00069.20 ESA17488.1 - 1e-26 93.6 0.5 1.3e-26 93.3 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17488.1 - 2.2e-25 89.1 0.0 3.4e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA17488.1 - 0.014 14.4 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA17488.1 - 0.021 14.5 0.0 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YchF-GTPase_C PF06071.8 ESA17488.1 - 0.038 13.7 0.3 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF933) Transposase_21 PF02992.9 ESA17489.1 - 0.01 14.9 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Transposase family tnp2 Methyltransf_6 PF03737.10 ESA17489.1 - 0.057 13.2 0.0 0.095 12.5 0.0 1.2 1 0 0 1 1 1 0 Demethylmenaquinone methyltransferase Mpp10 PF04006.7 ESA17490.1 - 0.61 8.3 24.8 0.98 7.7 17.2 1.2 1 0 0 1 1 1 0 Mpp10 protein Daxx PF03344.10 ESA17490.1 - 1.1 7.7 17.2 1.4 7.3 11.9 1.2 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESA17490.1 - 9 4.1 11.3 13 3.7 7.9 1.3 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.17 ESA17492.1 - 1.7e-15 56.3 0.1 3.6e-15 55.3 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA17492.1 - 8.6e-10 38.4 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 ESA17492.1 - 9.6e-09 35.5 4.6 9.6e-09 35.5 3.2 2.8 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_5 PF13893.1 ESA17492.1 - 0.00013 21.7 0.0 0.00021 21.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Erythro_esteras PF05139.9 ESA17493.1 - 5.1e-16 58.8 0.6 1.4e-15 57.3 0.4 1.6 1 1 0 1 1 1 1 Erythromycin esterase RNase_H2-Ydr279 PF09468.5 ESA17494.1 - 0.13 11.4 4.1 0.14 11.3 2.8 1.0 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF3381 PF11861.3 ESA17494.1 - 0.37 10.2 7.8 0.41 10.1 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF1682 PF07946.9 ESA17494.1 - 2.8 6.7 10.7 3.1 6.5 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pkinase PF00069.20 ESA17496.1 - 5.9e-33 114.1 1.7 6.8e-33 113.9 1.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17496.1 - 3e-32 111.6 0.5 3.7e-32 111.4 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA17496.1 - 0.00059 19.1 0.8 0.00084 18.6 0.4 1.4 1 1 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA17496.1 - 0.0013 17.7 0.1 0.0018 17.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA17496.1 - 0.0025 17.2 0.1 0.0067 15.8 0.0 1.6 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA17496.1 - 0.0033 17.2 0.0 0.004 16.9 0.0 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF3888 PF13027.1 ESA17496.1 - 0.063 13.1 0.4 0.14 12.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3888) Mannitol_dh PF01232.18 ESA17496.1 - 0.068 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Mannitol dehydrogenase Rossmann domain Sel1 PF08238.7 ESA17498.1 - 1.8e-61 203.2 31.0 3.7e-12 46.4 1.1 8.2 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA17498.1 - 4.9e-05 23.5 11.1 12 6.6 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat PFO_beta_C PF12367.3 ESA17498.1 - 0.0072 16.2 7.8 0.7 9.8 0.0 3.6 4 1 0 4 4 4 2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal DUF3296 PF11726.3 ESA17498.1 - 0.078 12.5 0.3 0.078 12.5 0.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3296) DUF2813 PF11398.3 ESA17498.1 - 0.4 9.7 4.6 0.85 8.6 0.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2813) BamHI PF02923.10 ESA17499.1 - 0.24 11.2 6.8 0.098 12.5 2.4 1.8 1 1 1 2 2 2 0 Restriction endonuclease BamHI Pkinase_Tyr PF07714.12 ESA17500.1 - 1.8e-44 151.7 0.0 2.3e-44 151.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17500.1 - 8.6e-41 139.7 0.0 1.4e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CENP-B_N PF04218.8 ESA17500.1 - 0.087 12.2 0.2 0.44 9.9 0.0 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Pkinase_Tyr PF07714.12 ESA17502.1 - 7e-09 35.1 0.0 1e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17502.1 - 0.0013 17.9 0.1 0.0046 16.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase PF00069.20 ESA17503.1 - 8.6e-32 110.2 0.1 1e-31 110.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17503.1 - 3.1e-30 105.1 0.0 3.5e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2004 PF09406.5 ESA17503.1 - 0.027 14.5 0.1 0.044 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) APH PF01636.18 ESA17503.1 - 0.1 12.3 0.1 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsbU PF06514.6 ESA17503.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) BTB PF00651.26 ESA17504.1 - 3.1e-18 65.7 0.4 4.9e-18 65.1 0.0 1.5 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA17504.1 - 0.0004 20.1 0.8 0.0016 18.2 0.1 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA17504.1 - 0.061 12.4 0.1 0.082 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.12 ESA17505.1 - 0.1 11.6 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Sel1 PF08238.7 ESA17506.1 - 2.7e-137 444.2 81.5 1.7e-12 47.5 1.8 13.0 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA17506.1 - 2.7e-18 65.0 40.6 0.69 10.4 0.0 12.2 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17506.1 - 1.5e-05 25.5 21.1 11 6.8 0.1 9.3 7 4 4 11 11 11 3 Tetratricopeptide repeat AMMECR1 PF01871.12 ESA17506.1 - 0.00055 19.1 0.2 3.7 6.6 0.0 4.0 3 1 1 4 4 4 1 AMMECR1 Flu_M1_C PF08289.6 ESA17506.1 - 0.0087 16.0 0.0 34 4.5 0.0 4.9 2 1 2 5 5 5 0 Influenza Matrix protein (M1) C-terminal domain STE PF02200.11 ESA17506.1 - 0.2 11.7 26.0 6.7 6.9 0.1 8.9 3 2 7 10 10 10 0 STE like transcription factor DUF512 PF04459.7 ESA17506.1 - 3.9 6.4 7.7 6.8 5.7 0.0 4.0 4 1 0 5 5 5 0 Protein of unknown function (DUF512) PH_4 PF15404.1 ESA17507.1 - 3.7e-44 150.4 6.8 6.2e-43 146.4 3.7 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 ESA17507.1 - 1.6e-17 63.5 4.5 9.5e-07 28.9 0.0 4.5 4 0 0 4 4 4 3 PH domain Spo7_2_N PF15407.1 ESA17507.1 - 2.7e-05 23.5 0.4 8.2e-05 21.9 0.3 1.8 1 0 0 1 1 1 1 Sporulation protein family 7 PH_6 PF15406.1 ESA17507.1 - 0.075 13.0 0.4 2.8 8.0 0.0 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain DUF2205 PF10224.4 ESA17508.1 - 6.3e-19 67.3 3.3 6.6e-19 67.2 2.3 1.0 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) BicD PF09730.4 ESA17508.1 - 0.025 12.9 0.6 0.026 12.9 0.4 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D FragX_IP PF05994.6 ESA17508.1 - 0.036 11.8 0.5 0.04 11.7 0.4 1.0 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family Wzz PF02706.10 ESA17508.1 - 0.063 13.0 0.4 0.076 12.8 0.3 1.2 1 0 0 1 1 1 0 Chain length determinant protein DUF3571 PF12095.3 ESA17508.1 - 0.066 13.4 0.4 0.079 13.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3571) Macoilin PF09726.4 ESA17508.1 - 0.1 10.8 0.8 0.11 10.7 0.5 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF972 PF06156.8 ESA17508.1 - 0.13 12.6 1.4 0.14 12.5 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) FliT PF05400.8 ESA17508.1 - 0.13 12.6 1.2 0.18 12.2 0.8 1.2 1 0 0 1 1 1 0 Flagellar protein FliT Sel1 PF08238.7 ESA17510.1 - 3e-149 482.2 82.4 7e-11 42.4 0.8 18.8 18 1 0 18 18 18 18 Sel1 repeat TPR_6 PF13174.1 ESA17510.1 - 1.9e-07 31.0 34.0 0.7 10.4 0.0 11.4 13 0 0 13 13 13 6 Tetratricopeptide repeat Myb_DNA-binding PF00249.26 ESA17511.1 - 6e-06 26.2 0.2 9.7e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA17511.1 - 3.7e-05 23.7 0.2 8.3e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain MTBP_C PF14920.1 ESA17511.1 - 1.7 8.0 13.5 2.1 7.7 9.3 1.2 1 0 0 1 1 1 0 MDM2-binding Pox_I1 PF03289.8 ESA17512.1 - 0.011 14.6 0.3 0.012 14.4 0.2 1.1 1 0 0 1 1 1 0 Poxvirus protein I1 TRF PF08558.5 ESA17512.1 - 0.069 12.4 0.3 0.071 12.4 0.2 1.1 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) AF0941-like PF14591.1 ESA17512.1 - 0.069 13.2 0.5 0.092 12.8 0.3 1.2 1 0 0 1 1 1 0 AF0941-like Ded_cyto PF06920.8 ESA17512.1 - 0.1 11.8 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Dedicator of cytokinesis TSSC4 PF15264.1 ESA17514.1 - 0.0072 16.7 5.0 0.76 10.2 0.2 3.1 3 0 0 3 3 3 2 Tumour suppressing sub-chromosomal transferable candidate 4 DUF3741 PF12552.3 ESA17514.1 - 0.021 14.5 4.5 12 5.6 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3741) DUF4116 PF13475.1 ESA17514.1 - 0.43 10.1 7.5 2.5 7.6 0.4 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF4116) DUF1870 PF08965.5 ESA17514.1 - 5.5 6.6 8.8 7.1 6.3 0.3 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF1870) RCC1 PF00415.13 ESA17515.1 - 1.2e-56 188.6 24.9 3.3e-10 40.0 0.0 8.6 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESA17515.1 - 1.7e-39 132.6 30.8 9.3e-11 41.0 0.1 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.1 ESA17515.1 - 0.0022 18.0 0.1 4.5 7.4 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4213) Pkinase PF00069.20 ESA17516.1 - 3.7e-71 239.3 0.0 4.7e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17516.1 - 1.3e-32 112.9 0.0 1.8e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 ESA17516.1 - 3.8e-11 43.3 4.6 9.9e-11 42.0 3.2 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 ESA17516.1 - 0.00071 18.6 0.0 0.0016 17.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA17516.1 - 0.07 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA17516.1 - 0.076 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family 3HCDH_N PF02737.13 ESA17517.1 - 1.5e-38 132.2 3.4 1.3e-24 86.8 0.1 2.1 1 1 1 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 ESA17517.1 - 0.00044 19.6 0.0 0.00062 19.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 ESA17517.1 - 0.0046 16.8 0.0 0.0069 16.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.16 ESA17517.1 - 0.0077 15.8 0.1 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DFP PF04127.10 ESA17517.1 - 0.011 15.4 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein MethyltransfD12 PF02086.10 ESA17517.1 - 0.017 14.5 0.3 0.023 14.1 0.2 1.4 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase XdhC_C PF13478.1 ESA17517.1 - 0.024 14.9 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain NAD_Gly3P_dh_N PF01210.18 ESA17517.1 - 0.084 12.6 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF2418 PF10332.4 ESA17518.1 - 0.00052 20.2 0.3 0.0013 18.9 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) NTase_sub_bind PF08780.6 ESA17518.1 - 0.0036 17.0 0.5 0.0036 17.0 0.3 2.6 3 0 0 3 3 3 1 Nucleotidyltransferase substrate binding protein like IFN-gamma PF00714.12 ESA17518.1 - 0.11 12.3 5.4 0.13 12.0 1.5 2.2 2 0 0 2 2 2 0 Interferon gamma Dimer_Tnp_hAT PF05699.9 ESA17520.1 - 1.4e-18 66.3 0.0 1.5e-18 66.2 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PTR PF12789.2 ESA17522.1 - 0.042 13.6 0.1 0.11 12.3 0.1 1.7 1 1 0 1 1 1 0 Phage tail repeat like Sel1 PF08238.7 ESA17525.1 - 3.4e-14 52.9 8.0 0.025 15.2 0.1 6.9 6 0 0 6 6 6 3 Sel1 repeat TPR_2 PF07719.12 ESA17525.1 - 6.2e-06 25.7 17.1 0.028 14.3 0.1 6.0 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17525.1 - 6.4e-05 22.8 9.5 0.11 12.5 0.1 4.9 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17525.1 - 0.00016 21.2 15.8 0.39 10.3 0.2 4.4 4 0 0 4 4 4 3 TPR repeat TPR_7 PF13176.1 ESA17525.1 - 0.00091 18.8 8.4 0.44 10.4 0.3 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17525.1 - 0.0011 19.3 0.8 7.3 7.5 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA17525.1 - 0.0026 17.3 20.4 0.014 15.0 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat DBP10CT PF08147.7 ESA17525.1 - 0.051 13.3 2.3 0.2 11.4 1.6 2.1 1 0 0 1 1 1 0 DBP10CT (NUC160) domain TPR_19 PF14559.1 ESA17525.1 - 2.7 8.4 11.7 7.7 6.9 0.1 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17525.1 - 4.5 7.2 21.0 1.9 8.4 0.1 5.5 4 1 1 5 5 5 0 Tetratricopeptide repeat Beta-TrCP_D PF12125.3 ESA17527.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 D domain of beta-TrCP TPR_11 PF13414.1 ESA17530.1 - 1.8e-23 81.9 20.5 3.4e-08 33.0 0.1 3.3 1 1 3 4 4 4 4 TPR repeat TPR_2 PF07719.12 ESA17530.1 - 2.8e-13 48.6 7.2 0.00018 21.1 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17530.1 - 1.6e-10 40.2 16.1 0.013 15.6 0.2 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA17530.1 - 1.8e-09 37.6 11.2 1.3e-06 28.4 0.7 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESA17530.1 - 9.7e-08 31.3 17.1 0.0041 16.6 0.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17530.1 - 7.4e-07 29.0 5.2 0.019 14.8 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17530.1 - 9.7e-06 25.0 22.9 0.017 14.8 0.2 5.3 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17530.1 - 4.5e-05 23.9 0.0 1.1 9.9 0.0 3.0 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA17530.1 - 0.0002 21.6 0.2 0.014 15.7 0.0 2.4 1 1 3 4 4 4 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA17530.1 - 0.0012 18.7 6.3 0.22 11.4 0.0 3.8 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ESA17530.1 - 0.0021 18.3 5.2 2.9 8.5 0.0 4.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17530.1 - 0.0066 16.1 0.5 1.8 8.5 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA17530.1 - 0.0089 15.8 0.0 0.41 10.5 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17530.1 - 0.012 16.2 0.0 22 6.0 0.0 3.3 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 ESA17530.1 - 0.031 14.0 0.1 0.031 14.0 0.1 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF627 PF04781.7 ESA17530.1 - 0.034 13.7 0.4 0.11 12.0 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF627) RINGv PF12906.2 ESA17531.1 - 2.3e-12 46.7 6.2 5.1e-12 45.6 4.3 1.6 1 0 0 1 1 1 1 RING-variant domain PHD PF00628.24 ESA17531.1 - 0.03 13.9 5.4 0.059 13.0 3.7 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.1 ESA17531.1 - 0.15 11.9 4.8 0.27 11.1 3.3 1.4 1 0 0 1 1 1 0 Ring finger domain FANCL_C PF11793.3 ESA17531.1 - 0.4 10.6 4.0 0.82 9.6 2.8 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Sensor PF13796.1 ESA17531.1 - 2.1 7.9 6.8 5.3 6.5 0.7 2.3 2 1 0 2 2 2 0 Putative sensor Acetyltransf_7 PF13508.1 ESA17532.1 - 1.7e-08 34.4 0.0 2.6e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 ESA17532.1 - 4.4e-08 33.0 0.0 6.5e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.1 ESA17532.1 - 0.0005 19.9 0.0 0.0012 18.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA17532.1 - 0.0012 18.7 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 ESA17532.1 - 0.0079 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_10 PF13673.1 ESA17532.1 - 0.02 15.0 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PAP2 PF01569.16 ESA17533.1 - 6.6e-16 58.1 1.5 1.2e-15 57.3 1.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.9 ESA17533.1 - 0.014 15.1 0.1 0.35 10.5 0.0 2.2 2 0 0 2 2 2 0 Divergent PAP2 family DUF2422 PF10337.4 ESA17533.1 - 0.12 11.1 4.6 0.17 10.6 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Bax1-I PF01027.15 ESA17533.1 - 0.56 9.7 12.4 3.4 7.2 8.6 1.9 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Peptidase_S8 PF00082.17 ESA17535.1 - 1.4e-12 47.3 1.3 2e-10 40.3 0.8 2.2 1 1 0 1 1 1 1 Subtilase family Peptidase_M85 PF13678.1 ESA17535.1 - 0.044 13.1 0.2 0.055 12.8 0.2 1.2 1 0 0 1 1 1 0 NFkB-p65-degrading zinc protease DUF1162 PF06650.7 ESA17536.1 - 5.5e-79 265.2 1.7 8.2e-76 254.8 0.1 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF1162) Chorein_N PF12624.2 ESA17536.1 - 2.2e-42 143.3 2.2 5.9e-42 141.9 1.5 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter ATG_C PF09333.6 ESA17536.1 - 4e-08 33.3 0.0 1.8e-07 31.2 0.0 2.2 1 0 0 1 1 1 1 ATG C terminal domain IL31 PF15209.1 ESA17537.1 - 0.042 13.4 0.1 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Interleukin 31 RAP PF08373.5 ESA17537.1 - 0.14 12.0 0.1 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 RAP domain TLD PF07534.11 ESA17539.1 - 4e-12 46.3 0.5 4e-12 46.3 0.3 2.0 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA17539.1 - 5.7e-12 45.6 0.2 1.5e-11 44.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17539.1 - 0.00019 21.2 3.5 0.00086 19.1 0.5 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA17542.1 - 7.2e-10 38.3 0.0 7.9e-10 38.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17542.1 - 1.2e-07 31.1 0.1 1.5e-07 30.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Docking PF08990.6 ESA17542.1 - 0.11 11.8 0.1 0.2 10.9 0.1 1.4 1 0 0 1 1 1 0 Erythronolide synthase docking Sel1 PF08238.7 ESA17543.1 - 1.6e-119 387.7 63.5 3.6e-12 46.5 0.5 12.1 12 0 0 12 12 12 12 Sel1 repeat Flu_M1_C PF08289.6 ESA17543.1 - 0.0081 16.1 0.3 22 5.1 0.0 5.0 3 2 3 6 6 6 1 Influenza Matrix protein (M1) C-terminal domain Aurora-A_bind PF09041.5 ESA17543.1 - 0.049 13.3 4.9 6.8 6.5 0.0 5.0 2 2 3 5 5 5 0 Aurora-A binding TPR_6 PF13174.1 ESA17543.1 - 1.2 9.7 37.7 1.9 9.1 0.1 9.9 12 0 0 12 12 12 0 Tetratricopeptide repeat Fic PF02661.13 ESA17543.1 - 2.6 8.7 4.7 35 5.1 0.9 4.1 3 1 1 4 4 4 0 Fic/DOC family MIT PF04212.13 ESA17543.1 - 4.6 7.1 37.6 1.3 9.0 0.4 8.6 7 2 1 8 8 8 0 MIT (microtubule interacting and transport) domain DUF3684 PF12449.3 ESA17544.1 - 3.4e-188 627.6 14.4 4.7e-186 620.5 5.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA17544.1 - 1.3e-05 24.8 0.2 4e-05 23.2 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OMP_b-brl_3 PF14905.1 ESA17545.1 - 0.0057 15.3 1.5 0.009 14.7 1.0 1.2 1 0 0 1 1 1 1 Outer membrane protein beta-barrel family MACPF PF01823.14 ESA17545.1 - 0.01 15.5 2.0 0.026 14.2 0.4 2.2 1 1 2 3 3 3 0 MAC/Perforin domain Sel1 PF08238.7 ESA17546.1 - 2.2e-69 228.3 40.2 4.5e-09 36.6 0.0 10.8 11 0 0 11 11 11 10 Sel1 repeat TPR_6 PF13174.1 ESA17546.1 - 0.014 15.8 16.3 31 5.3 0.0 8.6 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17546.1 - 1.2 8.7 37.8 0.091 12.4 3.6 6.6 2 2 2 5 5 5 0 TPR repeat TPR_12 PF13424.1 ESA17546.1 - 5.6 6.9 22.0 0.91 9.4 1.0 6.2 3 2 4 7 7 7 0 Tetratricopeptide repeat bZIP_C PF12498.3 ESA17548.1 - 0.44 11.7 6.5 0.62 11.3 4.5 1.2 1 0 0 1 1 1 0 Basic leucine-zipper C terminal PTRF_SDPR PF15237.1 ESA17549.1 - 0.25 10.6 1.6 0.36 10.1 1.1 1.1 1 0 0 1 1 1 0 PTRF/SDPR family AbiH PF14253.1 ESA17551.1 - 0.016 14.8 0.7 0.028 14.0 0.1 1.6 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH DUF659 PF04937.10 ESA17551.1 - 0.036 13.5 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Peptidase_C48 PF02902.14 ESA17555.1 - 7.1e-42 143.4 0.2 8.9e-42 143.1 0.1 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain LRR_6 PF13516.1 ESA17556.1 - 0.99 9.6 4.0 5.3 7.4 0.9 2.9 2 0 0 2 2 2 0 Leucine Rich repeat Pkinase_Tyr PF07714.12 ESA17557.1 - 1.5e-36 125.7 0.0 3.2e-36 124.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17557.1 - 3.6e-30 104.9 0.0 7.2e-30 103.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA17557.1 - 0.00024 20.9 0.0 0.00042 20.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA17557.1 - 0.011 15.3 0.1 0.89 9.0 0.0 2.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.9 ESA17557.1 - 0.012 14.7 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA17557.1 - 0.015 14.5 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA17557.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 RIO1 family AIG1 PF04548.11 ESA17559.1 - 6.9e-22 77.5 2.5 1.2e-21 76.8 1.8 1.3 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA17559.1 - 1.3e-09 38.0 1.2 5.9e-09 35.9 0.3 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA17559.1 - 0.004 16.3 0.9 0.013 14.6 0.1 2.2 2 1 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA17559.1 - 0.024 14.9 3.6 0.057 13.7 2.5 2.0 1 1 0 1 1 1 0 ABC transporter T2SE PF00437.15 ESA17559.1 - 0.044 12.6 0.2 0.078 11.8 0.1 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.21 ESA17559.1 - 0.046 13.1 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_29 PF13555.1 ESA17559.1 - 0.12 11.9 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.13 ESA17559.1 - 0.17 10.8 4.0 0.1 11.6 0.1 2.4 2 1 1 3 3 3 0 Septin AAA_10 PF12846.2 ESA17559.1 - 0.41 10.0 2.6 1.1 8.5 1.8 1.9 1 1 0 1 1 1 0 AAA-like domain Dynamin_N PF00350.18 ESA17559.1 - 0.74 9.6 4.3 5.8 6.6 3.0 2.5 1 1 0 1 1 1 0 Dynamin family POTRA_1 PF08478.5 ESA17561.1 - 0.0072 16.3 0.1 0.018 15.0 0.1 1.8 1 0 0 1 1 1 1 POTRA domain, FtsQ-type VWA_2 PF13519.1 ESA17564.1 - 2.7e-10 40.6 0.0 3.4e-10 40.2 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA17564.1 - 3.7e-05 23.5 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 ESA17564.1 - 0.008 15.3 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.4 ESA17564.1 - 0.016 15.0 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 vWA found in TerF C terminus Pox_LP_H2 PF03356.10 ESA17565.1 - 0.06 13.0 1.3 0.077 12.6 0.9 1.2 1 0 0 1 1 1 0 Viral late protein H2 TBPIP PF07106.8 ESA17568.1 - 0.00035 20.1 5.2 0.00042 19.8 3.6 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) pRN1_helical PF13010.1 ESA17568.1 - 0.0034 17.0 2.0 0.0034 17.0 1.4 1.4 1 1 1 2 2 2 1 Primase helical domain IncA PF04156.9 ESA17568.1 - 0.0051 16.4 7.9 0.0063 16.1 5.5 1.2 1 0 0 1 1 1 1 IncA protein Tmemb_cc2 PF10267.4 ESA17568.1 - 0.0065 15.0 5.5 0.0073 14.9 3.8 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein FH2 PF02181.18 ESA17568.1 - 0.014 14.2 4.9 0.015 14.1 3.4 1.0 1 0 0 1 1 1 0 Formin Homology 2 Domain DUF2408 PF10303.4 ESA17568.1 - 0.02 14.9 3.9 0.023 14.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) NYD-SP28 PF14772.1 ESA17568.1 - 0.027 14.5 7.0 0.035 14.2 4.9 1.2 1 0 0 1 1 1 0 Sperm tail Spectrin PF00435.16 ESA17568.1 - 0.041 14.1 6.5 0.084 13.1 4.5 1.5 1 1 0 1 1 1 0 Spectrin repeat TMF_TATA_bd PF12325.3 ESA17568.1 - 0.062 13.0 8.7 0.85 9.3 0.1 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding IFRD PF05004.8 ESA17568.1 - 0.1 11.6 2.0 0.11 11.5 1.4 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) DUF1635 PF07795.6 ESA17568.1 - 0.1 11.9 3.4 0.12 11.7 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) TPR_MLP1_2 PF07926.7 ESA17568.1 - 0.1 12.3 9.3 0.13 11.9 6.4 1.1 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein WbqC PF08889.6 ESA17568.1 - 0.11 11.9 0.7 0.12 11.8 0.5 1.0 1 0 0 1 1 1 0 WbqC-like protein family Atg14 PF10186.4 ESA17568.1 - 0.11 11.3 5.5 0.13 11.1 3.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 L31 PF09784.4 ESA17568.1 - 0.11 12.5 2.8 0.15 12.0 1.9 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF904 PF06005.7 ESA17568.1 - 0.12 12.6 12.0 1.8 8.8 4.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF342 PF03961.8 ESA17568.1 - 0.18 10.1 4.8 0.21 9.9 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF948 PF06103.6 ESA17568.1 - 0.22 11.4 2.4 3.1 7.7 1.5 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Nsp1_C PF05064.8 ESA17568.1 - 0.26 10.9 3.4 0.35 10.5 2.3 1.2 1 0 0 1 1 1 0 Nsp1-like C-terminal region Radial_spoke_3 PF06098.6 ESA17568.1 - 0.31 9.9 6.1 0.36 9.7 4.3 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 Streptin-Immun PF11083.3 ESA17568.1 - 0.49 10.4 5.4 1.5 8.8 3.5 1.9 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein Tropomyosin_1 PF12718.2 ESA17568.1 - 0.74 9.6 12.4 2.7 7.8 8.5 1.8 1 1 0 1 1 1 0 Tropomyosin like DUF972 PF06156.8 ESA17568.1 - 1.1 9.6 7.0 3.8 7.9 4.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Exonuc_VII_L PF02601.10 ESA17568.1 - 1.2 8.2 5.2 1.3 8.1 3.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.10 ESA17568.1 - 1.3 8.5 7.5 11 5.5 0.0 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF4200 PF13863.1 ESA17568.1 - 1.5 8.7 13.4 6.8 6.6 5.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) bZIP_2 PF07716.10 ESA17568.1 - 1.7 8.5 18.7 13 5.6 0.1 3.0 2 1 0 2 2 2 0 Basic region leucine zipper DUF4355 PF14265.1 ESA17568.1 - 9 6.2 12.5 12 5.8 8.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4355) bZIP_1 PF00170.16 ESA17568.1 - 9.1 6.3 17.2 2.3 8.2 2.1 2.4 1 1 2 3 3 3 0 bZIP transcription factor Desmo_N PF06771.6 ESA17569.1 - 0.025 14.4 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus Orexin_rec2 PF03827.8 ESA17571.1 - 0.084 12.9 0.1 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 Orexin receptor type 2 RNase_H PF00075.19 ESA17572.1 - 0.03 14.6 0.3 0.038 14.3 0.2 1.4 1 1 0 1 1 1 0 RNase H DDE_1 PF03184.14 ESA17575.1 - 3.1e-08 33.0 0.2 3.3e-08 32.9 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Ribosomal_L38e PF01781.13 ESA17575.1 - 0.031 14.0 0.1 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L38e protein family DDE_1 PF03184.14 ESA17576.1 - 1e-19 70.5 3.6 1.3e-19 70.1 0.5 2.2 2 1 1 3 3 3 1 DDE superfamily endonuclease DDE_1 PF03184.14 ESA17577.1 - 6.7e-25 87.5 1.3 8.8e-25 87.1 0.2 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA17577.1 - 3e-16 58.9 0.1 6.7e-16 57.8 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA17577.1 - 0.026 14.2 0.1 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease UN_NPL4 PF11543.3 ESA17577.1 - 0.04 14.1 0.1 5.3 7.3 0.0 2.4 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Prok-RING_1 PF14446.1 ESA17579.1 - 0.00018 21.1 0.6 0.00032 20.3 0.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Zeta_toxin PF06414.7 ESA17580.1 - 0.00096 18.3 0.5 0.044 12.8 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 ESA17580.1 - 0.0012 19.6 0.4 0.0025 18.5 0.3 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.8 ESA17580.1 - 0.011 14.6 0.4 2.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESA17580.1 - 0.014 15.0 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Part of AAA domain ArgK PF03308.11 ESA17580.1 - 0.038 12.7 1.0 0.1 11.3 0.0 1.9 2 0 0 2 2 2 0 ArgK protein cobW PF02492.14 ESA17580.1 - 0.086 12.2 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 ESA17580.1 - 0.1 12.5 11.0 0.07 13.0 5.4 2.4 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.22 ESA17580.1 - 0.14 12.4 0.6 0.37 11.0 0.4 1.8 1 1 0 1 1 1 0 ABC transporter Thymidylate_kin PF02223.12 ESA17580.1 - 0.29 10.4 6.0 6.1 6.1 4.2 2.8 1 1 0 1 1 1 0 Thymidylate kinase Myb_DNA-bind_3 PF12776.2 ESA17580.1 - 0.66 10.6 12.2 0.37 11.4 5.0 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Thioredoxin_8 PF13905.1 ESA17580.1 - 1.6 8.9 0.0 1.6 8.9 0.0 3.5 2 2 2 4 4 4 0 Thioredoxin-like AAA_11 PF13086.1 ESA17580.1 - 1.8 8.0 5.6 4.9 6.6 3.9 1.7 1 1 0 1 1 1 0 AAA domain RRM_3 PF08777.6 ESA17580.1 - 3.9 7.3 9.6 0.67 9.8 1.6 2.7 2 1 0 2 2 2 0 RNA binding motif NOC3p PF07540.6 ESA17581.1 - 0.064 13.5 1.9 0.21 11.8 0.7 2.2 2 1 0 2 2 2 0 Nucleolar complex-associated protein eIF3g PF12353.3 ESA17581.1 - 0.38 10.6 4.8 0.55 10.1 0.7 2.3 1 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Snapin_Pallidin PF14712.1 ESA17582.1 - 0.21 11.9 4.5 0.51 10.6 0.3 3.5 3 1 0 3 3 3 0 Snapin/Pallidin DUF916 PF06030.7 ESA17583.1 - 1.9 8.2 19.9 0.37 10.6 3.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) Myb_DNA-bind_4 PF13837.1 ESA17584.1 - 6.6e-11 42.2 0.4 1.2e-10 41.3 0.3 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA17584.1 - 1.8e-05 25.2 1.9 2.8e-05 24.6 0.7 1.7 1 1 1 2 2 2 1 Myb/SANT-like DNA-binding domain RdRP PF05183.7 ESA17585.1 - 2.1e-09 36.6 0.8 2.5e-09 36.4 0.1 1.5 2 0 0 2 2 2 1 RNA dependent RNA polymerase Imm6 PF14434.1 ESA17585.1 - 0.012 15.3 0.0 0.039 13.6 0.0 1.8 1 0 0 1 1 1 0 Immunity protein Imm6 DASH_Spc19 PF08287.6 ESA17588.1 - 0.052 13.1 0.8 0.053 13.1 0.5 1.0 1 0 0 1 1 1 0 Spc19 Exo_endo_phos_2 PF14529.1 ESA17589.1 - 7.2e-12 44.9 0.8 1.4e-11 44.0 0.6 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA17589.1 - 7e-07 29.4 0.0 8.9e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Nepo_coat_C PF03688.9 ESA17589.1 - 0.03 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Nepovirus coat protein, C-terminal domain Ly49 PF08391.5 ESA17589.1 - 0.19 11.8 5.1 0.053 13.6 1.2 1.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Endonuc-dimeris PF09124.5 ESA17591.1 - 0.096 12.3 0.1 0.31 10.7 0.1 1.8 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation DUF3684 PF12449.3 ESA17592.1 - 2e-232 774.0 6.0 2.6e-227 757.1 1.9 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA17592.1 - 3e-06 26.9 0.0 8.5e-06 25.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA17592.1 - 0.045 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.5 ESA17592.1 - 0.068 13.0 2.1 0.18 11.6 1.2 1.8 2 0 0 2 2 2 0 WLM domain AdoMet_MTase PF07757.8 ESA17593.1 - 0.015 15.4 0.1 0.028 14.5 0.1 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DUF2317 PF10079.4 ESA17593.1 - 0.025 13.2 0.2 0.037 12.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) ODV-E18 PF10717.4 ESA17597.1 - 0.23 10.8 3.9 0.12 11.7 0.5 1.9 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 RdRP PF05183.7 ESA17598.1 - 2e-08 33.4 0.2 7.1e-08 31.6 0.1 1.8 2 0 0 2 2 2 1 RNA dependent RNA polymerase Pkinase PF00069.20 ESA17600.1 - 6.6e-35 120.4 0.2 4.9e-28 97.9 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17600.1 - 9.2e-33 113.3 0.2 2.7e-25 88.9 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 ESA17600.1 - 0.00098 18.9 0.2 0.0019 17.9 0.2 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA17600.1 - 0.0031 16.7 0.0 0.0055 15.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA17600.1 - 0.0035 16.4 0.2 0.0054 15.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA17600.1 - 0.0069 15.7 0.0 0.024 14.0 0.0 1.9 2 0 0 2 2 2 1 RIO1 family DUF4286 PF14114.1 ESA17600.1 - 0.074 13.3 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) Pkinase_Tyr PF07714.12 ESA17602.1 - 1e-41 142.7 0.0 1.7e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17602.1 - 3.3e-38 131.3 0.1 5.4e-38 130.6 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA17602.1 - 0.0068 15.3 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA17602.1 - 0.019 14.3 0.6 0.041 13.2 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.9 ESA17602.1 - 0.033 13.2 0.0 0.06 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tbf5 PF06331.7 ESA17602.1 - 0.18 11.6 2.9 2.6 7.8 0.0 2.9 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Peptidase_S8 PF00082.17 ESA17604.1 - 1.5e-48 165.3 0.0 2.4e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 Subtilase family DUF1034 PF06280.7 ESA17604.1 - 4.9e-10 39.8 0.1 1.2e-09 38.5 0.1 1.7 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) Inhibitor_I9 PF05922.11 ESA17604.1 - 2.4e-05 24.8 0.9 7.1e-05 23.2 0.6 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 ATP-synt_S1 PF05827.7 ESA17605.1 - 0.058 12.7 0.0 0.062 12.5 0.0 1.1 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) NTP_transf_3 PF12804.2 ESA17605.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF3815 PF12821.2 ESA17608.1 - 0.12 12.3 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3815) p450 PF00067.17 ESA17610.1 - 7.2e-65 219.3 1.2 1.2e-64 218.6 0.8 1.2 1 0 0 1 1 1 1 Cytochrome P450 SWIRM PF04433.12 ESA17610.1 - 0.2 11.8 2.3 0.46 10.6 0.0 2.8 4 0 0 4 4 4 0 SWIRM domain WGR PF05406.10 ESA17611.1 - 0.00042 20.2 0.1 0.00073 19.4 0.1 1.4 1 0 0 1 1 1 1 WGR domain S-antigen PF05756.6 ESA17612.1 - 1.3 9.0 4.2 1.6 8.7 2.9 1.1 1 0 0 1 1 1 0 S-antigen protein Anemone_cytotox PF06369.7 ESA17614.1 - 9.9e-23 80.4 0.3 1.2e-22 80.1 0.2 1.0 1 0 0 1 1 1 1 Sea anemone cytotoxic protein Papilloma_E5 PF03025.9 ESA17615.1 - 0.23 11.4 1.4 0.29 11.1 1.0 1.2 1 0 0 1 1 1 0 Papillomavirus E5 BTB PF00651.26 ESA17616.1 - 5.3e-19 68.2 2.3 5.4e-19 68.2 0.4 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA17616.1 - 4.3e-05 23.3 1.4 0.00052 19.8 0.1 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch RdRP PF05183.7 ESA17618.1 - 5e-06 25.4 0.0 6.2e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pkinase_Tyr PF07714.12 ESA17620.1 - 9.1e-21 74.0 4.1 2.4e-17 62.8 0.5 3.9 4 1 1 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17620.1 - 7.3e-14 51.5 5.5 7.3e-14 51.5 3.8 3.2 3 1 1 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ESA17620.1 - 1.4e-07 31.2 3.7 0.0019 17.8 0.5 4.8 4 1 0 4 4 4 2 BCS1 N terminal Spt5-NGN PF03439.8 ESA17620.1 - 0.11 12.2 0.6 84 3.0 0.0 4.2 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section phage_tail_N PF08400.5 ESA17620.1 - 0.15 11.7 0.2 1.8 8.2 0.0 2.6 3 0 0 3 3 3 0 Prophage tail fibre N-terminal DUF4413 PF14372.1 ESA17620.1 - 0.57 10.2 9.9 0.75 9.8 0.3 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) BACK PF07707.10 ESA17621.1 - 2.4e-05 24.1 1.8 0.00023 20.9 1.0 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA17624.1 - 0.0045 16.9 0.5 0.0058 16.6 0.3 1.2 1 0 0 1 1 1 1 TLD DUF1279 PF06916.8 ESA17625.1 - 0.15 12.4 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) Peptidase_S32 PF05579.8 ESA17626.1 - 0.0012 17.9 0.1 0.026 13.5 0.0 2.1 2 0 0 2 2 2 1 Equine arteritis virus serine endopeptidase S32 DUF31 PF01732.11 ESA17626.1 - 0.002 17.4 0.1 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF31) Trypsin_2 PF13365.1 ESA17626.1 - 0.02 14.8 0.0 0.043 13.8 0.0 1.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain gag-asp_proteas PF13975.1 ESA17627.1 - 0.026 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Sel1 PF08238.7 ESA17628.1 - 6.2e-148 478.0 93.6 2.5e-11 43.8 0.3 15.0 15 0 0 15 15 15 15 Sel1 repeat Peptidase_C14 PF00656.17 ESA17628.1 - 2.7e-07 30.5 0.2 0.12 12.0 0.0 5.6 2 2 3 6 6 6 1 Caspase domain Flu_M1_C PF08289.6 ESA17628.1 - 0.0011 18.9 0.0 1.3e+02 2.7 0.0 5.6 3 1 3 6 6 6 0 Influenza Matrix protein (M1) C-terminal domain TPR_14 PF13428.1 ESA17628.1 - 0.004 17.6 5.6 11 6.9 0.0 6.6 7 1 1 8 8 8 1 Tetratricopeptide repeat MIT PF04212.13 ESA17628.1 - 0.0042 16.9 55.7 5.2 7.0 0.8 11.6 9 2 2 11 11 11 4 MIT (microtubule interacting and transport) domain DUF2530 PF10745.4 ESA17628.1 - 0.088 12.8 0.0 1.5e+02 2.4 0.0 5.8 9 0 0 9 9 9 0 Protein of unknown function (DUF2530) Phage_tail_2 PF06199.6 ESA17628.1 - 0.11 12.5 3.3 58 3.7 0.0 4.5 3 1 0 4 4 4 0 Phage major tail protein 2 Phage_T4_gp19 PF06841.7 ESA17628.1 - 0.92 9.1 7.6 15 5.2 0.1 5.9 3 2 4 7 7 7 0 T4-like virus tail tube protein gp19 HTH_16 PF12645.2 ESA17628.1 - 4.2 7.3 22.6 7.4 6.5 0.1 7.1 9 0 0 9 9 9 0 Helix-turn-helix domain UBA PF00627.26 ESA17628.1 - 4.4 7.2 7.7 1.7e+02 2.2 0.0 6.4 7 0 0 7 7 7 0 UBA/TS-N domain Pkinase_Tyr PF07714.12 ESA17629.1 - 0.013 14.5 0.1 0.021 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Josephin PF02099.12 ESA17631.1 - 0.032 13.8 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Josephin HSDR_N_2 PF13588.1 ESA17631.1 - 0.095 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF2087 PF09860.4 ESA17632.1 - 0.038 13.7 0.7 0.052 13.3 0.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) OGG_N PF07934.7 ESA17632.1 - 0.11 12.4 0.1 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain TLD PF07534.11 ESA17634.1 - 1.2e-12 48.0 5.8 1.5e-11 44.4 2.6 2.9 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA17634.1 - 9.5e-10 38.4 0.1 1.7e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17634.1 - 0.00011 22.0 0.6 0.00011 22.0 0.4 2.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA17634.1 - 0.11 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF4291 PF14124.1 ESA17635.1 - 7e-51 172.4 3.1 7.8e-51 172.2 2.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) MLANA PF14991.1 ESA17636.1 - 0.29 11.1 1.1 6.6 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein melan-A YwiC PF14256.1 ESA17636.1 - 6.6 6.8 9.1 0.3 11.1 0.1 3.0 4 0 0 4 4 4 0 YwiC-like protein Prefoldin_2 PF01920.15 ESA17637.1 - 0.0071 16.0 1.9 0.011 15.4 1.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit RRM_1 PF00076.17 ESA17637.1 - 0.084 12.5 0.5 0.21 11.2 0.1 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4446 PF14584.1 ESA17637.1 - 0.85 9.4 4.2 1.1 9.0 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF948 PF06103.6 ESA17637.1 - 3.4 7.5 5.8 18 5.2 0.6 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4117 PF13491.1 ESA17637.1 - 5.6 6.3 8.1 7.1 6.0 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4117) IncA PF04156.9 ESA17637.1 - 7.1 6.1 7.1 9.2 5.8 0.4 2.2 2 0 0 2 2 2 0 IncA protein Phasin PF05597.6 ESA17639.1 - 0.025 14.3 25.5 0.18 11.5 1.0 2.4 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) MbeD_MobD PF04899.7 ESA17639.1 - 0.039 13.8 10.6 0.62 10.0 2.7 3.0 2 1 0 2 2 2 0 MbeD/MobD like DUF4407 PF14362.1 ESA17639.1 - 0.24 10.3 15.8 0.35 9.7 10.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SPX PF03105.14 ESA17639.1 - 0.32 10.7 27.0 0.4 10.4 18.7 1.1 1 0 0 1 1 1 0 SPX domain YvrJ PF12841.2 ESA17639.1 - 0.43 9.9 5.9 1.1 8.6 0.9 2.8 2 0 0 2 2 2 0 YvrJ protein family MRP-S27 PF10037.4 ESA17639.1 - 0.82 8.5 23.5 1 8.1 16.3 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 bZIP_1 PF00170.16 ESA17639.1 - 2.1 8.3 22.6 0.57 10.1 3.6 3.2 2 2 1 3 3 3 0 bZIP transcription factor MtrG PF04210.8 ESA17639.1 - 2.2 8.0 9.4 2.7 7.7 0.1 3.0 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Mu-like_Pro PF10123.4 ESA17639.1 - 2.2 7.6 15.7 2.9 7.2 10.9 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein CDC45 PF02724.9 ESA17639.1 - 3.3 5.6 19.4 3.8 5.4 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4613 PF15390.1 ESA17639.1 - 4.8 5.2 17.7 5.2 5.1 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Vfa1 PF08432.5 ESA17639.1 - 9.2 6.2 30.9 20 5.1 21.4 1.5 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sulfate_transp PF00916.15 ESA17640.1 - 2.6e-67 226.7 10.4 2.6e-67 226.7 7.2 2.1 2 1 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 ESA17640.1 - 6.4e-28 96.2 5.3 6.4e-28 96.2 3.7 2.5 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 ESA17640.1 - 1.3e-22 79.4 0.1 2.6e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 ESA17640.1 - 0.0079 16.2 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 STAS domain DUF202 PF02656.10 ESA17640.1 - 3.5 7.9 8.7 2.6 8.3 0.2 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF202) SAM_2 PF07647.12 ESA17641.1 - 6.5e-19 67.5 0.1 1.3e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA17641.1 - 2e-15 56.6 0.2 4.1e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TMF_DNA_bd PF12329.3 ESA17641.1 - 0.0056 16.4 0.3 0.0098 15.6 0.2 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESA17641.1 - 0.024 14.1 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Septum formation initiator Med30 PF11315.3 ESA17641.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 Tht1 PF04163.7 ESA17642.1 - 2.1e-10 39.6 20.8 3e-10 39.1 14.4 1.2 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein DUF1664 PF07889.7 ESA17642.1 - 0.00065 19.4 2.9 0.0068 16.2 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Reo_sigmaC PF04582.7 ESA17642.1 - 0.0071 15.5 6.8 0.013 14.7 4.5 1.5 1 1 0 1 1 1 1 Reovirus sigma C capsid protein F-box PF00646.28 ESA17642.1 - 0.08 12.6 2.3 0.23 11.1 0.3 2.6 2 1 1 3 3 3 0 F-box domain SICA_C PF12879.2 ESA17642.1 - 0.12 12.2 1.5 0.21 11.4 1.0 1.5 1 0 0 1 1 1 0 SICA C-terminal inner membrane domain PMC2NT PF08066.7 ESA17642.1 - 0.19 12.0 3.3 0.19 12.0 0.3 2.4 2 1 1 3 3 3 0 PMC2NT (NUC016) domain RasGAP_C PF03836.10 ESA17642.1 - 0.21 11.2 8.1 0.24 11.0 4.3 2.1 1 1 1 2 2 2 0 RasGAP C-terminus DUF1451 PF07295.6 ESA17642.1 - 0.31 10.8 2.8 1.8 8.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1451) IncA PF04156.9 ESA17642.1 - 0.51 9.8 7.8 1.9 8.0 5.3 2.0 1 1 0 1 1 1 0 IncA protein Bacillus_HBL PF05791.6 ESA17642.1 - 0.85 8.9 12.7 0.16 11.3 2.3 2.3 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Z1 PF10593.4 ESA17642.1 - 4.4 6.4 8.3 1.7 7.7 1.6 2.1 1 1 0 2 2 2 0 Z1 domain FlaC_arch PF05377.6 ESA17642.1 - 8.4 6.3 11.1 3.5 7.6 2.4 3.6 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) HTH_39 PF14090.1 ESA17644.1 - 0.21 11.0 1.2 1.4 8.4 0.0 2.5 2 1 1 3 3 3 0 Helix-turn-helix domain Response_reg PF00072.19 ESA17647.1 - 3.3e-26 91.5 0.0 8.3e-26 90.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 ESA17647.1 - 1.6e-25 88.9 0.2 6.4e-25 87.0 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.1 ESA17647.1 - 1.7e-11 44.3 0.7 1.9e-05 24.7 0.2 3.9 3 1 0 3 3 3 2 GAF domain HisKA PF00512.20 ESA17647.1 - 3.7e-11 42.8 1.8 6.6e-11 42.0 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF PF01590.21 ESA17647.1 - 7.8e-08 32.5 0.0 2.1e-05 24.6 0.0 2.7 2 0 0 2 2 2 1 GAF domain PAS_4 PF08448.5 ESA17647.1 - 4.3e-05 23.5 0.0 9.9e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_2 PF13581.1 ESA17647.1 - 6.9e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_9 PF13426.1 ESA17647.1 - 0.00038 20.7 0.0 0.0013 19.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain HATPase_c_3 PF13589.1 ESA17647.1 - 0.0031 17.1 0.3 0.01 15.4 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.1 ESA17647.1 - 0.008 16.6 0.0 0.91 9.9 0.0 3.4 4 0 0 4 4 4 1 GAF domain KH_1 PF00013.24 ESA17648.1 - 6.1e-09 35.4 0.8 6.1e-09 35.4 0.6 2.8 3 0 0 3 3 3 1 KH domain KH_3 PF13014.1 ESA17648.1 - 0.00021 20.8 1.2 0.00068 19.2 0.8 2.0 1 0 0 1 1 1 1 KH domain Sel1 PF08238.7 ESA17649.1 - 1.5e-47 158.9 19.9 1.3e-13 51.0 0.7 4.6 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA17649.1 - 4e-07 30.0 8.1 0.089 13.2 0.2 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17649.1 - 1.1e-05 25.1 16.3 0.7 10.2 0.7 5.6 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17649.1 - 4.9e-05 22.8 24.9 0.013 15.1 6.3 3.4 1 1 3 4 4 4 2 TPR repeat TPR_16 PF13432.1 ESA17649.1 - 0.00019 22.0 0.6 0.29 11.8 0.0 3.2 1 1 3 4 4 4 2 Tetratricopeptide repeat MIT PF04212.13 ESA17649.1 - 0.0012 18.6 10.5 1.9 8.3 0.5 3.8 3 2 0 3 3 3 3 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA17649.1 - 0.0022 17.9 13.5 0.52 10.2 2.1 4.1 1 1 3 4 4 4 3 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA17649.1 - 0.015 15.0 0.5 15 5.4 0.0 3.3 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation CEP1-DNA_bind PF09287.5 ESA17649.1 - 0.036 13.4 0.2 1.1 8.6 0.0 2.1 1 1 1 2 2 2 0 CEP-1, DNA binding Apc3 PF12895.2 ESA17649.1 - 0.077 13.1 15.5 7.6 6.7 3.1 3.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HTH_16 PF12645.2 ESA17649.1 - 0.087 12.7 0.7 11 6.0 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain TPR_20 PF14561.1 ESA17649.1 - 0.12 12.4 1.3 9.3 6.4 0.1 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF3558 PF12079.3 ESA17649.1 - 0.18 11.4 0.4 21 4.6 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3558) Leuk-A4-hydro_C PF09127.6 ESA17649.1 - 0.29 10.7 3.7 3.3 7.3 0.1 2.2 1 1 1 2 2 2 0 Leukotriene A4 hydrolase, C-terminal TPR_2 PF07719.12 ESA17649.1 - 0.82 9.7 25.4 5.7 7.1 0.6 6.6 5 2 2 7 7 7 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 ESA17649.1 - 2.2 8.4 7.4 7.1 6.7 0.2 3.0 4 0 0 4 4 4 0 Rapamycin binding domain TPR_10 PF13374.1 ESA17649.1 - 3.9 7.5 17.1 7.9 6.5 1.0 5.2 4 3 0 4 4 4 0 Tetratricopeptide repeat eIF-5_eIF-2B PF01873.12 ESA17650.1 - 7.4e-05 22.4 1.4 0.0001 21.9 1.0 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 NMD3 PF04981.8 ESA17650.1 - 0.011 14.9 0.6 0.013 14.6 0.4 1.1 1 0 0 1 1 1 0 NMD3 family NAD_synthase PF02540.12 ESA17650.1 - 0.02 13.7 0.2 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 NAD synthase APP_Cu_bd PF12924.2 ESA17650.1 - 0.027 14.9 0.1 0.046 14.2 0.1 1.5 1 1 0 1 1 1 0 Copper-binding of amyloid precursor, CuBD DUF3624 PF12292.3 ESA17650.1 - 0.042 14.2 0.2 0.053 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) Pkinase PF00069.20 ESA17652.1 - 9.7e-22 77.3 9.5 1.1e-18 67.3 2.8 3.3 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17652.1 - 3.6e-16 59.0 6.5 1.2e-11 44.2 0.6 3.4 4 0 0 4 4 4 3 Protein tyrosine kinase Kdo PF06293.9 ESA17652.1 - 0.024 13.7 0.2 0.077 12.0 0.2 1.9 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA17653.1 - 4.9e-70 230.4 39.6 8.4e-12 45.3 0.1 7.8 8 0 0 8 8 8 7 Sel1 repeat TPR_17 PF13431.1 ESA17653.1 - 8.7e-06 25.5 18.2 6.9 7.1 0.0 7.2 7 1 0 7 7 6 2 Tetratricopeptide repeat HTH_16 PF12645.2 ESA17653.1 - 9.8e-06 25.4 2.6 0.56 10.1 0.0 4.6 5 0 0 5 5 5 2 Helix-turn-helix domain TPR_6 PF13174.1 ESA17653.1 - 4.8e-05 23.5 17.3 0.2 12.1 0.0 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17653.1 - 0.0016 19.0 2.4 22 5.8 0.0 4.5 2 2 3 5 5 5 0 Tetratricopeptide repeat DUF3881 PF12997.2 ESA17653.1 - 0.0052 15.8 0.6 1.1 8.2 0.0 3.3 4 0 0 4 4 4 1 Domain of unknown function, E. rectale Gene description (DUF3881) Flu_M1_C PF08289.6 ESA17653.1 - 0.015 15.3 0.0 0.77 9.8 0.0 3.2 1 1 2 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain TPR_12 PF13424.1 ESA17653.1 - 0.02 14.8 23.0 0.1 12.5 1.8 5.7 1 1 5 6 6 6 0 Tetratricopeptide repeat AKNA PF12443.3 ESA17653.1 - 0.06 13.3 0.0 1.2 9.1 0.0 2.7 3 0 0 3 3 3 0 AT-hook-containing transcription factor 23S_rRNA_IVP PF05635.6 ESA17653.1 - 0.13 12.1 4.7 0.3 10.9 0.2 2.9 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein STE PF02200.11 ESA17653.1 - 0.14 12.3 8.8 0.58 10.3 0.9 3.7 2 1 2 4 4 4 0 STE like transcription factor Surfac_D-trimer PF09006.6 ESA17653.1 - 0.15 11.8 5.0 28 4.5 0.0 4.7 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation Foie-gras_1 PF11817.3 ESA17653.1 - 0.37 10.2 10.7 1.9 7.9 1.4 4.2 1 1 1 2 2 2 0 Foie gras liver health family 1 DUF1100 PF06500.6 ESA17653.1 - 0.47 8.9 5.7 0.58 8.6 0.3 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1100) HMG_box_5 PF14887.1 ESA17653.1 - 2.2 8.1 15.9 4.6 7.1 0.4 4.6 2 2 2 5 5 5 0 HMG (high mobility group) box 5 MIT PF04212.13 ESA17653.1 - 9.5 6.1 20.4 2.7 7.9 0.6 5.3 4 3 2 6 6 6 0 MIT (microtubule interacting and transport) domain Ion_trans PF00520.26 ESA17654.1 - 4.3e-07 29.3 1.1 6.1e-07 28.8 0.7 1.2 1 0 0 1 1 1 1 Ion transport protein Fzo_mitofusin PF04799.8 ESA17654.1 - 0.02 14.3 2.8 0.031 13.6 2.0 1.3 1 0 0 1 1 1 0 fzo-like conserved region MerR-DNA-bind PF09278.6 ESA17654.1 - 0.25 11.7 1.8 1 9.7 0.9 2.2 2 1 0 2 2 2 0 MerR, DNA binding MotA_ExbB PF01618.11 ESA17654.1 - 0.82 9.2 3.8 1.5 8.4 2.6 1.5 1 0 0 1 1 1 0 MotA/TolQ/ExbB proton channel family DUF3901 PF13040.1 ESA17654.1 - 1.7 7.9 16.6 1.8 7.8 7.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3901) ING PF12998.2 ESA17654.1 - 2.5 8.4 10.0 0.2 11.9 3.8 1.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding 60KD_IMP PF02096.15 ESA17654.1 - 3.7 7.1 13.3 1.3 8.6 5.8 2.0 2 0 0 2 2 2 0 60Kd inner membrane protein CENP-C_mid PF15620.1 ESA17655.1 - 0.031 13.9 0.9 0.04 13.6 0.6 1.1 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region Corona_nucleoca PF00937.13 ESA17655.1 - 1 8.2 5.1 1.3 7.8 3.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein AhpC-TSA PF00578.16 ESA17658.1 - 0.24 11.0 2.1 1.8 8.2 0.1 2.5 2 1 0 2 2 2 0 AhpC/TSA family Cortex-I_coil PF09304.5 ESA17658.1 - 0.28 11.2 8.1 0.44 10.6 1.1 3.1 2 1 1 3 3 3 0 Cortexillin I, coiled coil FliS PF02561.9 ESA17658.1 - 0.39 10.5 10.6 0.035 13.9 0.9 2.5 1 1 1 2 2 2 0 Flagellar protein FliS DUF972 PF06156.8 ESA17658.1 - 1.5 9.1 11.8 3.6 7.9 3.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF972) MULE PF10551.4 ESA17659.1 - 0.029 14.5 0.1 0.032 14.3 0.1 1.2 1 0 0 1 1 1 0 MULE transposase domain FAR1 PF03101.10 ESA17660.1 - 0.045 14.2 0.1 0.067 13.7 0.1 1.2 1 0 0 1 1 1 0 FAR1 DNA-binding domain YpzG PF14139.1 ESA17660.1 - 0.93 9.4 3.2 2 8.3 0.4 2.4 2 1 1 3 3 3 0 YpzG-like protein Mito_carr PF00153.22 ESA17663.1 - 7.5e-11 41.5 1.1 1.1e-09 37.8 0.8 1.9 1 1 0 1 1 1 1 Mitochondrial carrier protein WD40 PF00400.27 ESA17664.1 - 2.7e-11 42.9 5.8 0.0074 16.1 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_2 PF13360.1 ESA17664.1 - 0.039 13.4 0.1 5.5 6.3 0.1 2.5 2 1 0 2 2 2 0 PQQ-like domain Reg_prop PF07494.6 ESA17664.1 - 0.16 12.1 0.7 1.1 9.4 0.1 2.8 3 0 0 3 3 3 0 Two component regulator propeller DDE_1 PF03184.14 ESA17665.1 - 3.5e-17 62.2 1.0 3.2e-11 42.7 0.1 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease CobT PF06213.7 ESA17665.1 - 0.00052 19.2 10.3 0.00076 18.6 7.1 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DUF1510 PF07423.6 ESA17665.1 - 0.058 12.7 15.8 0.082 12.2 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Astro_capsid PF03115.9 ESA17665.1 - 0.41 8.8 4.5 0.47 8.6 3.1 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF2407_C PF13373.1 ESA17665.1 - 2.7 7.9 7.4 32 4.4 5.4 2.0 2 0 0 2 2 2 0 DUF2407 C-terminal domain CDC45 PF02724.9 ESA17665.1 - 2.9 5.8 15.0 4 5.3 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DOMON PF03351.12 ESA17666.1 - 1.1e-07 31.7 0.0 2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.11 ESA17666.1 - 0.0022 17.8 6.2 0.0022 17.8 4.3 2.2 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF318 PF03773.8 ESA17666.1 - 0.017 14.0 0.1 0.017 14.0 0.0 2.2 2 0 0 2 2 2 0 Predicted permease DUF2702 PF10863.3 ESA17666.1 - 0.036 13.7 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2702) DUF4079 PF13301.1 ESA17666.1 - 0.093 12.7 5.8 0.16 11.9 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2633 PF11119.3 ESA17666.1 - 1.6 8.5 6.3 0.33 10.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2633) MULE PF10551.4 ESA17668.1 - 5e-15 55.4 0.2 1.2e-14 54.2 0.1 1.7 2 0 0 2 2 2 1 MULE transposase domain LRR_4 PF12799.2 ESA17669.1 - 0.022 14.4 3.9 0.022 14.4 2.7 5.0 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA17669.1 - 0.039 13.6 3.1 0.075 12.7 0.9 2.3 2 0 0 2 2 2 0 F-box-like DUF2608 PF11019.3 ESA17670.1 - 0.002 17.2 2.2 0.013 14.5 0.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2608) BatD PF13584.1 ESA17670.1 - 0.007 15.0 0.6 0.0084 14.7 0.4 1.0 1 0 0 1 1 1 1 Oxygen tolerance PspB PF06667.7 ESA17670.1 - 0.013 15.4 0.7 0.024 14.5 0.5 1.4 1 0 0 1 1 1 0 Phage shock protein B TMEM154 PF15102.1 ESA17670.1 - 0.037 13.7 0.6 0.045 13.4 0.4 1.3 1 0 0 1 1 1 0 TMEM154 protein family Pex2_Pex12 PF04757.9 ESA17673.1 - 5.9e-31 107.6 6.8 7.5e-31 107.3 4.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.1 ESA17673.1 - 4.8e-09 35.7 13.5 7.5e-09 35.1 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA17673.1 - 2e-07 30.9 17.8 3.6e-07 30.0 12.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA17673.1 - 3.7e-07 29.8 16.4 7.2e-07 28.9 11.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA17673.1 - 4.4e-06 26.2 17.7 8e-06 25.4 12.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA17673.1 - 8.3e-05 22.2 15.3 0.00015 21.4 10.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 ESA17673.1 - 0.037 14.1 7.4 0.068 13.2 5.1 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_6 PF14835.1 ESA17673.1 - 0.068 12.9 6.4 0.14 11.9 4.5 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESA17673.1 - 0.22 11.2 7.7 0.24 11.1 4.0 2.0 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA17673.1 - 0.35 10.7 13.8 1.4 8.8 9.6 2.0 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF1322 PF07032.6 ESA17674.1 - 0.085 13.0 0.6 8 6.7 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1322) Sdh_cyt PF01127.17 ESA17674.1 - 0.12 12.2 3.3 0.22 11.3 2.3 1.4 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit TatD_DNase PF01026.16 ESA17675.1 - 1.3e-52 178.5 0.0 1.5e-52 178.3 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Menin PF05053.8 ESA17675.1 - 1.3 7.0 4.3 1.7 6.7 3.0 1.1 1 0 0 1 1 1 0 Menin C2 PF00168.25 ESA17676.1 - 2.3e-12 46.5 0.0 3.5e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain NT-C2 PF10358.4 ESA17676.1 - 0.00019 20.9 0.0 0.00061 19.3 0.0 1.7 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins LRR_8 PF13855.1 ESA17677.1 - 0.13 12.0 0.3 0.13 12.0 0.2 5.1 6 2 0 6 6 6 0 Leucine rich repeat F-box-like PF12937.2 ESA17677.1 - 0.21 11.3 2.4 0.45 10.2 0.2 2.6 3 0 0 3 3 3 0 F-box-like LRR_4 PF12799.2 ESA17677.1 - 8.9 6.0 20.4 0.19 11.3 0.2 5.9 5 3 2 7 7 7 0 Leucine Rich repeats (2 copies) Zwint PF15556.1 ESA17678.1 - 1.1e-05 24.8 1.9 1.2e-05 24.7 1.3 1.1 1 0 0 1 1 1 1 ZW10 interactor GOLGA2L5 PF15070.1 ESA17678.1 - 0.0044 15.5 5.0 0.005 15.3 3.5 1.0 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 IFT57 PF10498.4 ESA17678.1 - 0.0072 15.1 5.8 0.0087 14.8 4.0 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 DivIC PF04977.10 ESA17678.1 - 0.0097 15.3 2.4 0.0097 15.3 1.7 1.6 1 1 1 2 2 2 1 Septum formation initiator Lge1 PF11488.3 ESA17678.1 - 0.02 15.0 5.6 0.091 12.9 3.3 2.4 1 1 2 3 3 3 0 Transcriptional regulatory protein LGE1 TBCA PF02970.11 ESA17678.1 - 0.034 14.2 3.1 0.041 13.9 2.1 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A Tropomyosin_1 PF12718.2 ESA17678.1 - 0.038 13.8 5.4 0.046 13.5 3.8 1.1 1 0 0 1 1 1 0 Tropomyosin like Atg14 PF10186.4 ESA17678.1 - 0.14 11.0 6.6 0.17 10.8 4.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 E2R135 PF11570.3 ESA17678.1 - 0.16 12.0 2.5 0.22 11.6 1.8 1.3 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF2450 PF10475.4 ESA17678.1 - 0.21 10.4 5.1 0.25 10.1 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) V_ATPase_I PF01496.14 ESA17678.1 - 0.41 8.4 4.3 0.45 8.3 3.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family THOC7 PF05615.8 ESA17678.1 - 0.45 10.7 7.6 0.48 10.7 4.6 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 Spc24 PF08286.6 ESA17678.1 - 1.1 8.9 7.9 1.8 8.3 5.3 1.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Pkinase PF00069.20 ESA17684.1 - 4.4e-39 134.2 0.2 4.8e-39 134.0 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17684.1 - 2.8e-37 128.1 0.1 3.3e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA17684.1 - 0.0021 17.8 0.1 0.003 17.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA17684.1 - 0.0052 16.1 0.1 0.0059 15.9 0.1 1.1 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA17684.1 - 0.011 15.0 0.1 0.019 14.3 0.1 1.3 1 0 0 1 1 1 0 RIO1 family WaaY PF06176.6 ESA17684.1 - 0.016 14.4 0.7 0.022 13.9 0.5 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA17684.1 - 0.034 13.1 0.1 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_pol_Rpb4 PF03874.11 ESA17684.1 - 0.058 13.4 0.4 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb4 RdgC PF04381.7 ESA17684.1 - 0.11 11.3 0.5 0.34 9.8 0.0 1.8 2 0 0 2 2 2 0 Putative exonuclease, RdgC Pkinase_Tyr PF07714.12 ESA17685.1 - 2.3e-32 112.0 0.0 1.9e-26 92.7 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17685.1 - 1.6e-25 89.7 0.1 5e-23 81.5 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA17685.1 - 0.0053 16.5 0.1 0.011 15.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family PyrI_C PF02748.10 ESA17685.1 - 0.25 10.8 3.8 20 4.7 0.0 3.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DAO PF01266.19 ESA17686.1 - 1.4e-13 50.5 0.0 2.1e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA17686.1 - 0.00045 20.1 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 ESA17686.1 - 0.0046 17.3 0.0 0.024 15.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA17686.1 - 0.0059 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.12 ESA17686.1 - 0.0073 15.4 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 ESA17686.1 - 0.016 14.1 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.9 ESA17686.1 - 0.035 13.9 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 ESA17686.1 - 0.035 13.1 0.0 0.054 12.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.1 ESA17686.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_2 PF00890.19 ESA17686.1 - 0.057 12.2 0.0 0.083 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 ESA17686.1 - 0.07 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ESA17686.1 - 0.087 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 ESA17686.1 - 0.1 11.2 0.1 0.22 10.1 0.0 1.6 2 0 0 2 2 2 0 Tryptophan halogenase CWC25 PF12542.3 ESA17687.1 - 1.2e-22 80.1 0.3 1.2e-22 80.1 0.2 5.4 3 2 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.4 ESA17687.1 - 5.7e-13 48.6 16.3 5.7e-13 48.6 11.3 6.0 3 2 2 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR Bromodomain PF00439.20 ESA17687.1 - 0.015 15.2 1.2 0.015 15.2 0.8 2.1 2 0 0 2 2 2 0 Bromodomain CBFD_NFYB_HMF PF00808.18 ESA17688.1 - 5.2e-15 55.2 0.2 1e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF605 PF04652.11 ESA17688.1 - 1.4 8.2 17.0 1.8 7.8 11.8 1.2 1 0 0 1 1 1 0 Vta1 like BUD22 PF09073.5 ESA17688.1 - 5.8 5.8 31.7 8.2 5.3 22.0 1.3 1 0 0 1 1 1 0 BUD22 PX PF00787.19 ESA17689.1 - 1.6e-26 92.3 0.0 1.8e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 PX domain zf-BED PF02892.10 ESA17691.1 - 0.064 13.0 1.0 0.11 12.2 0.7 1.4 1 0 0 1 1 1 0 BED zinc finger ALIX_LYPXL_bnd PF13949.1 ESA17691.1 - 0.07 12.0 2.0 0.32 9.9 0.4 1.9 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV Sas10_Utp3 PF04000.10 ESA17691.1 - 0.099 12.8 0.3 0.23 11.6 0.1 1.7 2 0 0 2 2 2 0 Sas10/Utp3/C1D family zf-C2H2_2 PF12756.2 ESA17691.1 - 0.11 12.6 2.8 0.16 12.1 1.5 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.9 ESA17691.1 - 0.11 11.9 0.5 0.11 11.9 0.3 2.8 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF2120 PF09893.4 ESA17691.1 - 0.71 9.8 4.5 0.63 9.9 2.2 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DUF1002 PF06207.6 ESA17691.1 - 0.97 8.7 5.2 2.6 7.2 3.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) THP2 PF09432.5 ESA17691.1 - 1.4 8.8 5.0 0.83 9.5 1.4 1.9 2 0 0 2 2 2 0 Tho complex subunit THP2 Syntaxin PF00804.20 ESA17691.1 - 2.4 8.3 8.2 90 3.3 5.7 2.2 1 1 0 1 1 1 0 Syntaxin PRD PF00874.15 ESA17691.1 - 4.9 7.3 7.7 2.8 8.1 3.3 1.9 2 0 0 2 2 2 0 PRD domain Methyltransf_15 PF09445.5 ESA17692.1 - 1.8e-44 151.2 0.5 4e-44 150.0 0.3 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.13 ESA17692.1 - 3.2e-11 43.1 0.0 5.2e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.1 ESA17692.1 - 4.2e-10 39.4 3.2 1.3e-09 37.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA17692.1 - 2.7e-09 37.0 0.0 5.1e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA17692.1 - 3.4e-07 30.8 0.0 9.1e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 ESA17692.1 - 1.4e-06 27.8 0.0 3.1e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Met_10 PF02475.11 ESA17692.1 - 6.2e-06 25.9 0.1 1.7e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.8 ESA17692.1 - 0.00054 19.1 0.0 0.0017 17.5 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 ESA17692.1 - 0.00093 19.6 0.0 0.0051 17.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESA17692.1 - 0.0043 16.4 0.0 0.015 14.6 0.0 1.9 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_3 PF01596.12 ESA17692.1 - 0.005 15.9 0.1 0.025 13.6 0.0 2.0 2 0 0 2 2 2 1 O-methyltransferase ADH_zinc_N PF00107.21 ESA17692.1 - 0.036 13.6 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.13 ESA17692.1 - 0.046 13.3 0.1 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_2 PF13639.1 ESA17693.1 - 8e-10 38.3 7.5 8e-10 38.3 5.2 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA17693.1 - 1.6e-09 37.2 4.4 5.2e-09 35.6 3.0 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA17693.1 - 1.3e-07 31.1 6.9 1.3e-07 31.1 4.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA17693.1 - 2.5e-07 30.6 7.6 2.5e-07 30.6 5.2 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA17693.1 - 6.1e-07 29.0 6.9 2.3e-06 27.2 4.8 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-CCCH PF00642.19 ESA17693.1 - 8e-06 25.4 27.0 0.00022 20.7 3.4 4.3 4 0 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_UBOX PF13445.1 ESA17693.1 - 0.00025 20.7 3.7 0.00076 19.1 0.8 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA17693.1 - 0.0081 16.0 8.5 0.085 12.7 6.1 2.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.1 ESA17693.1 - 0.0083 16.0 31.4 0.024 14.6 5.0 4.3 4 1 0 4 4 4 3 Zinc finger C-x8-C-x5-C-x3-H type Vps39_2 PF10367.4 ESA17693.1 - 0.63 10.2 6.4 0.96 9.6 1.1 2.3 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Zn-ribbon_8 PF09723.5 ESA17693.1 - 1.5 8.7 6.0 0.14 12.1 0.5 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zf-rbx1 PF12678.2 ESA17693.1 - 2.3 8.3 17.2 0.21 11.7 6.4 3.3 3 1 0 3 3 2 0 RING-H2 zinc finger zf-MIZ PF02891.15 ESA17693.1 - 2.6 7.6 9.5 9.6 5.8 6.6 2.0 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_6 PF14835.1 ESA17693.1 - 3.7 7.4 6.5 16 5.3 4.5 2.0 1 1 0 1 1 1 0 zf-RING of BARD1-type protein IL1 PF00340.14 ESA17694.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Interleukin-1 / 18 zf-C2H2_4 PF13894.1 ESA17695.1 - 4.1e-08 32.9 27.3 0.00072 19.7 0.4 6.2 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA17695.1 - 1.8e-07 31.1 35.0 0.033 14.5 0.3 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESA17695.1 - 6.3e-05 23.0 25.2 0.025 14.7 0.1 5.1 2 2 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 ESA17695.1 - 0.001 19.1 27.1 0.002 18.2 6.8 4.5 2 2 3 5 5 5 3 C2H2 type zinc-finger (2 copies) Late_protein_L2 PF00513.13 ESA17695.1 - 0.095 11.5 8.9 0.16 10.8 6.2 1.3 1 0 0 1 1 1 0 Late Protein L2 zf-trcl PF13451.1 ESA17695.1 - 0.17 11.5 0.2 0.17 11.5 0.1 3.4 3 0 0 3 3 3 0 Probable zinc-binding domain DUF2457 PF10446.4 ESA17695.1 - 0.48 9.0 18.2 0.82 8.3 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TEX19 PF15553.1 ESA17695.1 - 0.55 10.0 10.8 1.3 8.8 7.5 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 Mucin PF01456.12 ESA17695.1 - 0.89 9.3 10.6 1.4 8.6 7.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Mem_trans PF03547.13 ESA17695.1 - 1 7.6 3.5 1.2 7.3 2.4 1.2 1 0 0 1 1 1 0 Membrane transport protein zinc_ribbon_5 PF13719.1 ESA17695.1 - 1.5 8.4 16.1 15 5.2 0.1 5.5 5 0 0 5 5 5 0 zinc-ribbon domain zf-met PF12874.2 ESA17695.1 - 2.7 8.3 28.9 4.2 7.6 0.1 5.7 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Mut7-C PF01927.11 ESA17695.1 - 3.2 7.7 25.2 1.2 9.0 4.7 4.3 2 2 0 2 2 2 0 Mut7-C RNAse domain Prog_receptor PF02161.10 ESA17695.1 - 3.7 6.2 6.0 5.4 5.7 4.2 1.2 1 0 0 1 1 1 0 Progesterone receptor zinc_ribbon_4 PF13717.1 ESA17695.1 - 4 7.2 17.4 16 5.2 0.1 5.5 5 0 0 5 5 5 0 zinc-ribbon domain Nucleoside_tran PF01733.13 ESA17695.1 - 5.9 5.9 4.9 11 5.1 3.4 1.4 1 0 0 1 1 1 0 Nucleoside transporter Ribosomal_L37ae PF01780.14 ESA17695.1 - 7.8 6.4 8.8 0.37 10.6 0.3 2.9 3 1 0 3 3 2 0 Ribosomal L37ae protein family zf-C2H2 PF00096.21 ESA17696.1 - 4e-11 42.5 121.6 0.037 14.3 0.6 15.3 15 0 0 15 15 15 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA17696.1 - 1.2e-07 31.5 110.9 0.024 14.9 0.3 15.3 15 0 0 15 15 15 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA17696.1 - 3.6e-07 30.1 89.9 0.011 15.8 0.1 12.5 13 0 0 13 13 13 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA17696.1 - 0.00058 19.9 74.8 0.051 13.7 0.1 11.1 11 0 0 11 11 11 5 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESA17696.1 - 0.004 17.2 92.2 0.01 15.9 5.9 9.4 5 3 4 9 9 9 3 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.7 ESA17696.1 - 0.038 14.1 0.2 0.038 14.1 0.1 11.4 6 4 6 12 12 12 0 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.6 ESA17696.1 - 0.054 13.0 6.8 0.2 11.2 0.2 4.4 3 1 1 4 4 4 0 GAGA factor DUF1662 PF07878.6 ESA17696.1 - 2.1 8.1 4.6 23 4.8 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1662) Transposase_21 PF02992.9 ESA17697.1 - 0.0062 15.6 0.1 0.0083 15.2 0.1 1.2 1 0 0 1 1 1 1 Transposase family tnp2 APOBEC_C PF05240.9 ESA17697.1 - 0.14 11.6 0.2 0.28 10.6 0.2 1.5 1 0 0 1 1 1 0 APOBEC-like C-terminal domain Nop14 PF04147.7 ESA17698.1 - 0.0082 14.1 0.9 0.013 13.5 0.6 1.2 1 0 0 1 1 1 1 Nop14-like family Mito_fiss_reg PF05308.6 ESA17698.1 - 0.57 9.5 5.3 0.92 8.8 3.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF1202 PF06717.6 ESA17699.1 - 0.0041 16.4 4.8 0.0074 15.6 3.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1202) Cohesin_HEAT PF12765.2 ESA17700.1 - 1.2e-12 47.4 0.6 3e-12 46.2 0.4 1.7 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.1 ESA17700.1 - 0.0056 16.9 0.0 0.029 14.6 0.0 2.2 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.17 ESA17700.1 - 0.019 15.0 0.3 0.14 12.3 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat zf-C2H2_jaz PF12171.3 ESA17701.1 - 1.3e-06 28.3 0.9 4.6e-05 23.4 0.1 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESA17701.1 - 5.1e-05 23.3 6.3 6e-05 23.1 1.4 2.4 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.2 ESA17701.1 - 7.3e-05 22.8 4.7 0.00086 19.4 1.3 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.1 ESA17701.1 - 9e-05 22.4 1.3 9e-05 22.4 0.9 2.3 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-met2 PF12907.2 ESA17701.1 - 0.00052 19.9 0.2 0.0012 18.7 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding zf-C2H2_4 PF13894.1 ESA17701.1 - 0.0061 16.8 2.0 0.0061 16.8 1.4 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESA17701.1 - 0.0088 16.1 0.5 0.012 15.7 0.3 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-U1 PF06220.7 ESA17701.1 - 0.035 13.6 1.1 0.055 13.0 0.7 1.3 1 0 0 1 1 1 0 U1 zinc finger Methyltransf_23 PF13489.1 ESA17702.1 - 4.2e-13 49.3 0.0 5.6e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA17702.1 - 6.1e-13 48.6 0.0 1.2e-05 24.8 0.0 2.4 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 ESA17702.1 - 2.1e-12 47.3 0.0 3.4e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA17702.1 - 2.2e-09 36.7 0.0 3.4e-08 32.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA17702.1 - 6.4e-09 36.3 0.0 5.1e-08 33.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA17702.1 - 1e-07 32.2 0.0 2.4e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA17702.1 - 7.8e-07 29.5 0.0 1.5e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA17702.1 - 4.9e-06 26.0 0.0 5.5e-05 22.6 0.0 2.0 1 1 1 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.12 ESA17702.1 - 2.3e-05 23.5 0.1 0.0011 18.0 0.0 2.5 3 0 0 3 3 3 1 Putative methyltransferase CheR PF01739.13 ESA17702.1 - 7.5e-05 22.1 0.0 0.00029 20.2 0.0 1.8 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_9 PF08003.6 ESA17702.1 - 0.00013 20.7 0.0 0.00023 19.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_26 PF13659.1 ESA17702.1 - 0.00016 21.7 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA17702.1 - 0.0012 18.2 0.0 0.0029 16.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 ESA17702.1 - 0.0049 16.4 0.0 0.0099 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.9 ESA17702.1 - 0.011 14.8 0.0 0.054 12.6 0.0 2.0 1 1 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 ESA17702.1 - 0.075 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.11 ESA17702.1 - 0.077 11.3 0.0 0.15 10.3 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Vfa1 PF08432.5 ESA17703.1 - 0.2 11.6 4.8 0.26 11.2 3.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 F-box-like PF12937.2 ESA17704.1 - 7.1e-06 25.6 0.5 2.9e-05 23.6 0.3 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA17704.1 - 0.012 15.2 0.8 0.48 10.1 0.1 3.3 2 0 0 2 2 2 0 F-box domain DUF3586 PF12131.3 ESA17704.1 - 0.35 10.9 1.9 0.93 9.5 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) LRR_8 PF13855.1 ESA17704.1 - 1.9 8.3 13.1 2.1 8.1 0.2 5.0 3 3 2 5 5 5 0 Leucine rich repeat UQ_con PF00179.21 ESA17705.1 - 1e-47 161.0 0.1 1.2e-47 160.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA17705.1 - 0.0013 18.4 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Piwi PF02171.12 ESA17706.1 - 8e-44 149.8 2.3 7.2e-20 71.1 0.0 3.3 1 1 2 3 3 3 3 Piwi domain PAZ PF02170.17 ESA17706.1 - 2.4e-19 68.9 3.1 6.2e-19 67.6 2.1 1.6 1 0 0 1 1 1 1 PAZ domain DBR1 PF05011.8 ESA17707.1 - 0.022 14.6 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain NAD_binding_8 PF13450.1 ESA17708.1 - 0.018 15.0 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA17708.1 - 0.045 13.5 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding BTB PF00651.26 ESA17710.1 - 3.7e-18 65.5 0.2 6.7e-18 64.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA17710.1 - 5.7e-11 42.5 3.7 1e-10 41.7 1.6 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA17710.1 - 2.1e-05 24.2 1.5 0.00055 19.7 0.1 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch DS PF01916.12 ESA17710.1 - 0.016 14.3 0.3 0.042 12.9 0.1 1.7 2 0 0 2 2 2 0 Deoxyhypusine synthase Sialidase PF02973.11 ESA17711.1 - 0.024 13.6 0.4 0.059 12.3 0.2 1.6 1 1 0 1 1 1 0 Sialidase, N-terminal domain MIR PF02815.14 ESA17712.1 - 0.0079 15.7 0.0 0.0079 15.7 0.0 1.1 1 0 0 1 1 1 1 MIR domain Ins145_P3_rec PF08709.6 ESA17712.1 - 0.065 12.2 0.0 0.065 12.2 0.0 1.1 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor WH2 PF02205.15 ESA17712.1 - 0.15 11.7 0.1 0.45 10.1 0.0 1.8 2 0 0 2 2 2 0 WH2 motif Rep_2 PF01719.12 ESA17714.1 - 0.0034 16.9 6.5 0.0099 15.4 0.3 2.4 1 1 1 2 2 2 2 Plasmid replication protein HypA PF01155.14 ESA17714.1 - 0.046 13.4 0.1 0.085 12.5 0.1 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_2 PF13240.1 ESA17714.1 - 0.049 13.1 3.1 0.82 9.2 1.7 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 ESA17714.1 - 0.27 11.0 3.1 0.48 10.2 2.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon Hexokinase_1 PF00349.16 ESA17715.1 - 6.2e-53 179.1 0.0 1.6e-52 177.8 0.0 1.7 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 ESA17715.1 - 1.1e-49 168.8 0.1 1.5e-49 168.3 0.1 1.1 1 0 0 1 1 1 1 Hexokinase CD34_antigen PF06365.7 ESA17716.1 - 0.043 13.4 0.0 0.62 9.6 0.0 2.2 2 0 0 2 2 2 0 CD34/Podocalyxin family DUF3993 PF13158.1 ESA17717.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3993) DUF4227 PF14004.1 ESA17717.1 - 0.22 11.3 1.8 0.88 9.4 1.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) p450 PF00067.17 ESA17719.1 - 5.6e-38 130.6 0.1 6.6e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MACPF PF01823.14 ESA17721.1 - 8.4e-08 32.1 0.3 2.5e-07 30.6 0.2 1.8 1 0 0 1 1 1 1 MAC/Perforin domain Chlorophyllase2 PF12740.2 ESA17721.1 - 0.015 14.1 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF884 PF05959.6 ESA17722.1 - 0.099 11.9 0.9 0.2 10.9 0.2 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF884) BEX PF04538.7 ESA17722.1 - 0.41 10.8 6.7 2.6 8.3 0.8 2.3 2 0 0 2 2 2 0 Brain expressed X-linked like family DDE_1 PF03184.14 ESA17723.1 - 4.1e-34 117.6 3.0 4.8e-29 101.0 0.7 3.1 2 1 1 3 3 3 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA17723.1 - 2.6e-08 33.5 0.1 7.3e-08 32.1 0.1 1.8 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA17723.1 - 1.4e-06 27.6 0.2 4e-06 26.1 0.2 1.8 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_24 PF13412.1 ESA17723.1 - 0.0012 18.2 0.7 0.0041 16.4 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding DDE_3 PF13358.1 ESA17723.1 - 0.0052 16.5 0.4 0.018 14.8 0.0 2.1 2 0 0 2 2 2 1 DDE superfamily endonuclease Phage_terminase PF10668.4 ESA17723.1 - 0.011 15.5 1.2 1.7 8.5 0.2 2.7 2 0 0 2 2 2 0 Phage terminase small subunit HTH_37 PF13744.1 ESA17723.1 - 0.016 15.0 0.1 0.058 13.2 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain TrbM PF07424.6 ESA17723.1 - 0.02 14.8 0.1 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 TrbM Phage_CI_repr PF07022.8 ESA17723.1 - 0.038 14.0 0.1 1.6 8.8 0.0 2.8 2 1 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain HTH_26 PF13443.1 ESA17723.1 - 0.055 13.6 0.2 0.29 11.3 0.1 2.3 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Sigma70_r4 PF04545.11 ESA17723.1 - 0.056 12.7 0.0 0.22 10.8 0.0 2.0 1 0 0 1 1 1 0 Sigma-70, region 4 HSP70 PF00012.15 ESA17724.1 - 4.3e-140 467.4 2.5 8.8e-140 466.4 1.7 1.5 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA17724.1 - 2.2e-12 46.2 0.8 4.2e-10 38.7 0.0 2.6 3 0 0 3 3 3 2 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA17724.1 - 0.0096 15.0 0.0 0.27 10.3 0.0 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.15 ESA17724.1 - 0.017 14.4 0.0 0.18 11.0 0.0 2.2 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DUF4445 PF14574.1 ESA17724.1 - 0.019 13.2 0.0 0.15 10.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4445) FGGY_C PF02782.11 ESA17724.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF3439 PF11921.3 ESA17725.1 - 0.017 14.8 0.4 0.024 14.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF3034 PF11231.3 ESA17726.1 - 0.051 12.9 0.0 0.051 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3034) Sel1 PF08238.7 ESA17727.1 - 1e-49 165.8 12.2 6.7e-12 45.6 1.0 6.1 5 1 1 6 6 6 5 Sel1 repeat MIT PF04212.13 ESA17727.1 - 1.3e-05 24.9 11.6 0.0032 17.2 0.2 4.6 4 1 1 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA17727.1 - 0.0001 22.4 7.6 1.3 9.6 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17727.1 - 0.00025 20.6 21.5 0.081 12.5 0.9 5.1 1 1 4 5 5 5 4 TPR repeat TPR_12 PF13424.1 ESA17727.1 - 0.034 14.0 12.4 11 6.0 0.3 5.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17727.1 - 0.044 13.6 7.2 0.39 10.6 0.1 4.6 3 2 2 5 5 5 0 Tetratricopeptide repeat DASH_Dam1 PF08653.5 ESA17727.1 - 0.94 9.2 3.9 11 5.8 0.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 TPR_19 PF14559.1 ESA17727.1 - 5.3 7.4 9.1 4.9 7.5 0.1 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat AIG1 PF04548.11 ESA17728.1 - 3.5e-25 88.3 0.4 4.5e-25 88.0 0.3 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA17728.1 - 1.5e-07 31.3 0.2 2.3e-07 30.7 0.2 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA17728.1 - 0.00076 19.3 2.6 0.0065 16.2 0.1 2.8 1 1 2 3 3 3 1 Dynamin family AAA_22 PF13401.1 ESA17728.1 - 0.0082 16.2 0.2 0.021 14.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 ESA17728.1 - 0.051 12.9 0.0 8.2 5.7 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase NAD_binding_1 PF00175.16 ESA17733.1 - 2.8e-15 56.8 0.0 2.8e-13 50.3 0.0 2.2 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 ESA17733.1 - 4e-06 26.8 0.2 7.7e-05 22.6 0.0 2.2 2 1 0 2 2 2 1 Ferric reductase NAD binding domain Nop14 PF04147.7 ESA17734.1 - 0.02 12.8 16.9 0.026 12.4 11.7 1.1 1 0 0 1 1 1 0 Nop14-like family Beta-APP PF03494.8 ESA17734.1 - 0.075 12.5 2.2 0.14 11.6 1.5 1.4 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Daxx PF03344.10 ESA17734.1 - 0.12 10.8 20.4 0.18 10.2 14.1 1.2 1 0 0 1 1 1 0 Daxx Family CDC45 PF02724.9 ESA17734.1 - 6.4 4.6 15.7 8.8 4.2 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein HMG_box PF00505.14 ESA17735.1 - 5.5e-15 55.3 0.7 7.5e-15 54.9 0.5 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA17735.1 - 0.0013 19.0 0.5 0.0021 18.3 0.3 1.4 1 0 0 1 1 1 1 HMG-box domain DUF1986 PF09342.6 ESA17735.1 - 0.034 13.4 0.0 0.038 13.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Med26 PF08711.6 ESA17735.1 - 0.041 13.3 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 TFIIS helical bundle-like domain Linocin_M18 PF04454.7 ESA17735.1 - 0.053 12.4 0.1 0.091 11.6 0.0 1.3 1 1 0 1 1 1 0 Encapsulating protein for peroxidase DUF3199 PF11436.3 ESA17735.1 - 0.054 13.3 0.4 0.058 13.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3199) HMG_box PF00505.14 ESA17736.1 - 6.4e-05 23.1 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box Pkinase_Tyr PF07714.12 ESA17737.1 - 0.0079 15.2 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17737.1 - 0.025 13.7 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain YyzF PF14116.1 ESA17737.1 - 0.51 10.3 2.3 0.84 9.6 0.0 2.3 3 0 0 3 3 3 0 YyzF-like protein zf-CCHC PF00098.18 ESA17738.1 - 1.7e-22 78.2 72.5 6.2e-06 25.8 2.3 8.8 9 0 0 9 9 9 7 Zinc knuckle zf-CCHC_3 PF13917.1 ESA17738.1 - 4e-07 29.6 43.0 0.0035 17.0 1.3 7.7 5 2 3 8 8 8 6 Zinc knuckle zf-CCHC_5 PF14787.1 ESA17738.1 - 4.9e-07 29.1 31.9 0.4 10.2 0.2 7.9 8 0 0 8 8 8 6 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 ESA17738.1 - 3.6e-06 26.5 58.3 0.043 13.4 0.5 7.6 8 0 0 8 8 8 7 Zinc knuckle AgrD PF05931.6 ESA17738.1 - 0.93 9.1 4.0 8.5 6.1 0.1 2.5 2 0 0 2 2 2 0 Staphylococcal AgrD protein EamA PF00892.15 ESA17739.1 - 1.2e-09 38.3 4.4 1.2e-09 38.3 3.0 1.9 2 0 0 2 2 2 1 EamA-like transporter family UPF0546 PF10639.4 ESA17739.1 - 1.8e-05 24.4 2.2 2.7e-05 23.9 1.5 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0546 EmrE PF13536.1 ESA17739.1 - 0.00014 22.0 6.5 0.00014 22.0 4.5 1.9 1 1 1 2 2 2 1 Multidrug resistance efflux transporter TPT PF03151.11 ESA17739.1 - 0.084 12.5 10.3 0.026 14.1 4.7 1.9 1 1 0 2 2 2 0 Triose-phosphate Transporter family Multi_Drug_Res PF00893.14 ESA17739.1 - 0.14 12.6 5.3 0.13 12.7 2.4 1.9 1 1 0 1 1 1 0 Small Multidrug Resistance protein UAA PF08449.6 ESA17739.1 - 0.16 10.8 7.5 0.22 10.3 4.9 1.6 1 1 0 1 1 1 0 UAA transporter family Sin_N PF04801.8 ESA17741.1 - 1.7e-38 132.6 2.5 1e-37 130.0 1.7 1.9 1 1 0 1 1 1 1 Sin-like protein conserved region Peptidase_M20 PF01546.23 ESA17742.1 - 5.3e-30 104.3 0.0 6.7e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESA17742.1 - 9e-13 47.9 0.0 1.4e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 ESA17742.1 - 0.023 14.4 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 PB1 PF00564.19 ESA17742.1 - 0.076 12.6 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 PB1 domain Raptor_N PF14538.1 ESA17742.1 - 0.097 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain MIR PF02815.14 ESA17745.1 - 0.0035 16.8 0.4 0.28 10.7 0.0 2.5 1 1 1 2 2 2 2 MIR domain Microcin PF03526.8 ESA17745.1 - 0.07 12.7 0.4 0.19 11.3 0.1 1.8 2 0 0 2 2 2 0 Colicin E1 (microcin) immunity protein MIR PF02815.14 ESA17747.1 - 0.00078 19.0 0.2 0.003 17.1 0.1 2.0 1 1 0 1 1 1 1 MIR domain DUF4430 PF14478.1 ESA17747.1 - 0.034 14.2 0.3 0.22 11.5 0.2 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4430) Ins145_P3_rec PF08709.6 ESA17749.1 - 0.016 14.2 0.0 0.075 12.0 0.0 2.0 2 0 0 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Cys_rich_VLP PF14194.1 ESA17750.1 - 0.04 13.6 0.1 0.087 12.5 0.1 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP Chitin_synth_2 PF03142.10 ESA17751.1 - 5.7e-233 774.1 0.6 7.8e-233 773.6 0.4 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.1 ESA17751.1 - 1.9e-19 70.3 0.0 1.5e-16 60.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 ESA17751.1 - 8.5e-19 68.0 8.8 3.7e-18 65.9 6.1 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.23 ESA17751.1 - 2.1e-09 37.0 0.0 1.5e-06 27.9 0.0 2.6 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 ESA17751.1 - 2.1e-07 30.4 0.0 5.7e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 ESA17751.1 - 0.00065 19.4 2.2 0.0014 18.3 0.0 2.6 3 0 0 3 3 3 1 Glycosyl transferase family 2 Ank_2 PF12796.2 ESA17752.1 - 3.2e-42 142.7 10.3 1e-21 77.0 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESA17752.1 - 1.4e-40 135.1 6.7 1.4e-07 30.9 0.0 5.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 ESA17752.1 - 4.5e-38 128.9 10.2 6.7e-11 42.3 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA17752.1 - 5.4e-30 102.7 8.9 4.3e-10 39.5 0.0 5.3 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA17752.1 - 4.6e-28 94.4 5.4 6.6e-05 22.7 0.1 5.7 6 0 0 6 6 6 5 Ankyrin repeat DUF4413 PF14372.1 ESA17753.1 - 4.9e-09 36.0 1.0 1e-08 35.0 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4413) DUF573 PF04504.9 ESA17754.1 - 0.12 12.6 1.4 0.19 12.0 1.0 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF573 Pkinase_Tyr PF07714.12 ESA17755.1 - 9.6e-26 90.3 0.0 1.2e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17755.1 - 1.7e-25 89.6 0.0 2.3e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF3960 PF13142.1 ESA17755.1 - 0.078 12.7 0.8 0.38 10.5 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3960) TRAM_LAG1_CLN8 PF03798.11 ESA17756.1 - 7.9e-41 139.7 28.1 7.9e-41 139.7 19.5 2.1 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.6 ESA17756.1 - 1.4e-17 62.9 0.2 1.4e-17 62.9 0.1 2.8 2 0 0 2 2 2 1 TRAM1-like protein Tubulin PF00091.20 ESA17757.1 - 2.9e-70 236.4 0.0 4.4e-70 235.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESA17757.1 - 9.7e-50 167.8 0.0 1.6e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESA17757.1 - 6.1e-06 26.2 0.1 1.6e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESA17757.1 - 0.0021 17.5 0.0 0.0041 16.5 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RE_ScaI PF09569.5 ESA17759.1 - 0.013 15.0 0.2 0.015 14.8 0.1 1.1 1 0 0 1 1 1 0 ScaI restriction endonuclease DUF1451 PF07295.6 ESA17759.1 - 0.29 10.9 2.7 0.39 10.4 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1451) MreB_Mbl PF06723.8 ESA17760.1 - 0.0016 17.0 0.1 0.43 9.1 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein DJ-1_PfpI PF01965.19 ESA17760.1 - 0.0049 16.3 0.0 0.0088 15.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family HSP70 PF00012.15 ESA17760.1 - 0.0097 13.8 0.0 2.4 5.9 0.0 2.8 3 0 0 3 3 3 2 Hsp70 protein DUF3336 PF11815.3 ESA17762.1 - 0.12 11.8 1.2 1.2 8.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3336) Leu_zip PF15294.1 ESA17763.1 - 0.00076 18.6 25.9 0.0043 16.2 7.3 4.4 1 1 3 4 4 4 3 Leucine zipper HALZ PF02183.13 ESA17763.1 - 0.56 9.9 45.3 2.3 8.0 1.1 5.9 2 2 3 5 5 5 0 Homeobox associated leucine zipper CCDC155 PF14662.1 ESA17763.1 - 3.6 7.1 61.1 2.3 7.7 21.7 3.4 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 Speriolin_N PF15058.1 ESA17763.1 - 7.6 6.3 16.5 1 9.2 3.2 2.4 2 0 0 2 2 2 0 Speriolin N terminus Tim17 PF02466.14 ESA17764.1 - 3.3e-32 111.2 6.3 4e-32 110.9 4.4 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pkinase PF00069.20 ESA17765.1 - 1.2e-60 204.9 0.1 2.6e-60 203.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17765.1 - 5.9e-30 104.1 0.0 9.5e-30 103.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA17765.1 - 0.0021 17.0 0.0 0.0051 15.8 0.0 1.6 1 0 0 1 1 1 1 Kinase-like bZIP_1 PF00170.16 ESA17767.1 - 1.3e-05 25.0 2.3 2.3e-05 24.2 1.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor SPT16 PF08644.6 ESA17767.1 - 0.016 15.0 0.8 0.026 14.3 0.2 1.5 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) ATG16 PF08614.6 ESA17767.1 - 0.019 14.7 3.1 0.023 14.5 0.7 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) HeH PF12949.2 ESA17768.1 - 5.3e-07 29.0 0.1 9.9e-07 28.2 0.1 1.5 1 0 0 1 1 1 1 HeH/LEM domain Armet PF10208.4 ESA17768.1 - 0.0085 15.7 0.3 0.017 14.7 0.1 1.6 1 1 0 1 1 1 1 Degradation arginine-rich protein for mis-folding Macoilin PF09726.4 ESA17768.1 - 0.17 10.1 9.0 0.22 9.7 6.2 1.1 1 0 0 1 1 1 0 Transmembrane protein IMD PF08397.6 ESA17768.1 - 0.25 10.6 11.5 0.091 12.0 6.1 1.5 2 0 0 2 2 2 0 IRSp53/MIM homology domain DUF4300 PF14133.1 ESA17768.1 - 1.1 8.5 9.9 2.2 7.5 6.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4300) Cut8_N PF14482.1 ESA17768.1 - 1.7 8.6 14.3 0.26 11.3 6.9 1.9 2 0 0 2 2 2 0 Cut8 proteasome-binding domain DUF3298 PF11738.3 ESA17768.1 - 5.9 7.4 6.6 5.9 7.4 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3298) IBR PF01485.16 ESA17769.1 - 2.4e-19 68.9 45.5 2.9e-11 43.0 3.5 4.3 3 1 1 4 4 4 2 IBR domain zf-C3HC4_2 PF13923.1 ESA17769.1 - 4.2e-06 26.6 8.7 4.2e-06 26.6 6.1 4.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA17769.1 - 0.00034 20.2 9.6 0.00034 20.2 6.7 4.3 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA17769.1 - 0.0016 18.2 8.1 0.0016 18.2 5.6 3.5 3 0 0 3 3 3 1 Ring finger domain LRR_4 PF12799.2 ESA17772.1 - 0.14 11.8 6.3 0.17 11.5 1.0 3.3 2 2 0 2 2 2 0 Leucine Rich repeats (2 copies) FNIP PF05725.7 ESA17772.1 - 3.8 7.5 12.6 11 6.1 0.4 4.3 4 2 1 5 5 5 0 FNIP Repeat BTB PF00651.26 ESA17774.1 - 1e-12 48.0 0.0 1.9e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17774.1 - 4.5e-06 26.4 2.5 1e-05 25.2 0.8 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch MIR PF02815.14 ESA17775.1 - 2e-05 24.2 0.5 0.13 11.7 0.0 3.1 1 1 2 3 3 3 3 MIR domain MIR PF02815.14 ESA17776.1 - 0.0039 16.7 0.0 0.04 13.4 0.0 1.8 1 1 1 2 2 2 1 MIR domain Ins145_P3_rec PF08709.6 ESA17776.1 - 0.026 13.5 0.1 0.12 11.3 0.1 1.9 1 1 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA17778.1 - 0.00078 19.0 1.3 0.19 11.2 0.0 3.1 1 1 2 3 3 3 3 MIR domain Ins145_P3_rec PF08709.6 ESA17778.1 - 0.0053 15.8 0.3 0.017 14.1 0.1 2.0 1 1 1 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF2683 PF10884.3 ESA17778.1 - 0.2 11.5 5.7 0.67 9.9 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2683) Pkinase PF00069.20 ESA17779.1 - 4.5e-16 58.7 1.9 1.6e-15 56.9 1.3 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17779.1 - 2.5e-11 43.1 0.0 5.8e-11 41.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA17779.1 - 0.2 11.3 0.0 0.27 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family HypA PF01155.14 ESA17779.1 - 0.2 11.3 1.4 0.33 10.6 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Pkinase_Tyr PF07714.12 ESA17782.1 - 4.7e-37 127.4 0.0 6.7e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17782.1 - 2.1e-33 115.5 0.0 3.4e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17783.1 - 1.3e-32 112.9 0.0 5.5e-21 74.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17783.1 - 1.7e-31 109.3 0.1 1.2e-28 99.9 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA17783.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA17784.1 - 1.3e-06 28.0 0.2 4.6e-06 26.2 0.1 2.0 1 0 0 1 1 1 1 F-box-like Apc9 PF12856.2 ESA17788.1 - 0.028 14.4 1.2 0.036 14.1 0.8 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 Abhydrolase_6 PF12697.2 ESA17789.1 - 0.00025 21.0 0.0 0.00025 21.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA17789.1 - 0.032 13.7 0.0 0.032 13.7 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Metallophos PF00149.23 ESA17790.1 - 9.4e-16 57.7 1.8 2.3e-15 56.5 1.2 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3671 PF12420.3 ESA17793.1 - 0.12 12.3 5.2 0.065 13.2 1.2 2.0 1 1 1 2 2 2 0 Protein of unknown function zf-C2H2 PF00096.21 ESA17795.1 - 4.5e-10 39.2 42.0 0.14 12.5 1.1 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA17795.1 - 1e-09 38.0 32.5 0.015 15.5 0.6 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_2 PF12756.2 ESA17795.1 - 0.00026 21.0 34.4 0.08 13.0 1.3 5.2 1 1 3 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 ESA17795.1 - 0.0018 18.3 1.4 0.0018 18.3 1.0 6.0 7 0 0 7 7 7 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 ESA17795.1 - 0.0024 18.0 56.4 0.052 13.8 3.8 7.5 7 1 1 8 8 7 4 Zinc-finger double domain Zn-ribbon_8 PF09723.5 ESA17795.1 - 0.022 14.6 25.3 0.061 13.2 2.8 5.2 3 2 1 4 4 4 0 Zinc ribbon domain zf-C2H2_jaz PF12171.3 ESA17795.1 - 0.094 12.8 0.3 0.094 12.8 0.2 5.8 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-met2 PF12907.2 ESA17795.1 - 0.22 11.5 0.2 0.22 11.5 0.2 6.3 3 2 3 6 6 6 0 Zinc-binding zf-C2HC_2 PF13913.1 ESA17795.1 - 4.6 7.0 14.7 0.46 10.2 0.1 4.0 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Astro_capsid PF03115.9 ESA17795.1 - 4.8 5.3 10.5 0.11 10.7 2.8 1.5 2 0 0 2 2 2 0 Astrovirus capsid protein precursor zf-C2H2_6 PF13912.1 ESA17795.1 - 5.7 6.9 33.4 4.6 7.2 3.1 6.5 5 1 1 6 6 6 0 C2H2-type zinc finger zinc_ribbon_5 PF13719.1 ESA17795.1 - 7.8 6.1 25.6 2 8.0 0.0 5.5 5 1 0 5 5 5 0 zinc-ribbon domain DUF3399 PF11879.3 ESA17796.1 - 0.075 13.2 4.7 0.21 11.8 3.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) Pkinase PF00069.20 ESA17797.1 - 4.2e-70 235.8 0.0 4.7e-70 235.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17797.1 - 7.4e-31 107.1 0.0 9.2e-31 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA17797.1 - 0.00019 20.4 0.0 0.0056 15.6 0.0 2.2 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 ESA17797.1 - 0.0069 16.1 0.1 0.012 15.3 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 ESA17797.1 - 0.068 11.9 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 DnaJ PF00226.26 ESA17802.1 - 8e-18 63.9 0.1 1.5e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain UPF0086 PF01868.11 ESA17803.1 - 0.025 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function UPF0086 FAR1 PF03101.10 ESA17804.1 - 0.037 14.5 2.5 0.042 14.3 1.7 1.1 1 0 0 1 1 1 0 FAR1 DNA-binding domain Tenui_NS3 PF05310.7 ESA17804.1 - 0.12 12.2 1.7 0.12 12.2 1.2 1.1 1 0 0 1 1 1 0 Tenuivirus movement protein MULE PF10551.4 ESA17805.1 - 4e-06 26.8 0.0 8.3e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain TLD PF07534.11 ESA17806.1 - 6.6e-14 52.0 0.9 8.2e-14 51.7 0.6 1.1 1 0 0 1 1 1 1 TLD Kelch_3 PF13415.1 ESA17806.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Galactose oxidase, central domain COPI_assoc PF08507.5 ESA17807.1 - 0.068 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 COPI associated protein DDE_1 PF03184.14 ESA17808.1 - 4.7e-21 74.9 2.5 7.4e-16 57.9 0.2 2.4 2 1 1 3 3 3 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA17808.1 - 0.0038 17.0 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA17808.1 - 0.023 14.4 0.1 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease PX PF00787.19 ESA17810.1 - 0.014 15.1 0.2 0.016 14.9 0.2 1.2 1 0 0 1 1 1 0 PX domain DUF3800 PF12686.2 ESA17810.1 - 0.035 13.7 3.2 0.037 13.6 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) BACK PF07707.10 ESA17811.1 - 1.3e-08 34.6 4.5 8.5e-08 31.9 0.5 3.4 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA17811.1 - 2.9e-08 33.6 0.1 1.1e-07 31.8 0.1 2.0 1 1 0 1 1 1 1 BTB/POZ domain DUF1767 PF08585.7 ESA17811.1 - 0.037 14.2 0.5 4.1 7.7 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1767) RPM2 PF08579.6 ESA17811.1 - 0.22 11.6 2.4 0.52 10.4 0.0 2.8 3 1 0 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) Pkinase_Tyr PF07714.12 ESA17812.1 - 0.035 13.1 0.1 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.20 ESA17812.1 - 0.06 12.4 0.1 5.5 6.0 0.0 2.1 1 1 1 2 2 2 0 Protein kinase domain Sel1 PF08238.7 ESA17814.1 - 3.1e-07 30.8 0.2 5e-07 30.1 0.2 1.4 1 0 0 1 1 1 1 Sel1 repeat TPR_17 PF13431.1 ESA17814.1 - 0.034 14.3 0.1 0.39 11.0 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA17814.1 - 0.052 14.0 0.1 0.076 13.4 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3679 PF12438.3 ESA17814.1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3679) TPR_11 PF13414.1 ESA17814.1 - 0.099 12.3 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 TPR repeat Sel1 PF08238.7 ESA17815.1 - 0.005 17.4 0.0 0.0067 17.0 0.0 1.2 1 0 0 1 1 1 1 Sel1 repeat Pkinase PF00069.20 ESA17816.1 - 0.00031 19.9 1.5 0.0034 16.5 0.8 1.9 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17816.1 - 0.0024 16.9 2.1 0.028 13.5 0.6 2.0 1 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 ESA17816.1 - 0.03 13.4 0.3 0.03 13.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family COG5 PF10392.4 ESA17817.1 - 6.5e-05 22.8 1.5 0.00017 21.5 1.1 1.7 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps51 PF08700.6 ESA17817.1 - 0.0014 18.3 0.8 0.0014 18.3 0.6 2.5 3 1 0 3 3 3 1 Vps51/Vps67 Sec8_exocyst PF04048.9 ESA17817.1 - 0.0019 17.8 5.5 0.006 16.2 3.8 1.9 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain COG2 PF06148.6 ESA17817.1 - 0.003 17.4 11.0 0.012 15.4 3.5 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2450 PF10475.4 ESA17817.1 - 0.0037 16.2 12.4 0.0056 15.6 8.6 1.2 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) Vps53_N PF04100.7 ESA17817.1 - 0.0039 16.0 9.9 0.0052 15.6 6.8 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal Sec5 PF15469.1 ESA17817.1 - 0.18 11.4 10.4 0.049 13.3 4.8 1.8 2 0 0 2 2 2 0 Exocyst complex component Sec5 DUF4206 PF13901.1 ESA17817.1 - 0.26 10.8 5.3 0.24 10.9 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4206) DUF4304 PF14137.1 ESA17817.1 - 0.28 11.3 2.8 0.87 9.7 0.1 2.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4304) NOB1_Zn_bind PF08772.6 ESA17818.1 - 0.015 15.1 0.1 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Adeno_E3 PF06040.6 ESA17818.1 - 1.6 8.6 4.4 2.4 8.1 2.7 1.9 1 1 0 1 1 1 0 Adenovirus E3 protein LETM1 PF07766.8 ESA17819.1 - 6.4e-108 359.8 5.1 6.4e-108 359.8 3.5 2.5 2 1 0 2 2 2 1 LETM1-like protein SAP PF02037.22 ESA17819.1 - 0.00052 19.4 0.0 0.027 13.9 0.0 2.8 2 0 0 2 2 2 1 SAP domain EF-hand_6 PF13405.1 ESA17819.1 - 0.0006 19.4 0.0 0.69 9.9 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 ESA17819.1 - 0.0026 16.9 2.3 1.3 8.4 0.1 3.9 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 ESA17819.1 - 0.0034 17.5 2.4 0.016 15.3 0.3 3.1 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 ESA17819.1 - 0.0067 16.0 0.1 0.023 14.3 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 ESA17819.1 - 0.18 11.2 1.9 11 5.5 0.1 3.2 3 0 0 3 3 3 0 EF hand SURF6 PF04935.7 ESA17820.1 - 8.3e-30 103.6 56.3 8.3e-30 103.6 39.0 4.3 1 1 2 3 3 3 1 Surfeit locus protein 6 AMP-binding_C PF13193.1 ESA17821.1 - 2.1e-13 51.0 0.0 2.6e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Metal_hydrol PF10118.4 ESA17821.1 - 0.13 11.7 0.1 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Predicted metal-dependent hydrolase TLD PF07534.11 ESA17823.1 - 2.5e-10 40.4 2.8 6.6e-10 39.1 1.9 1.7 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA17824.1 - 2e-15 56.7 0.0 4.7e-15 55.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17824.1 - 4.5e-05 23.2 0.9 0.00044 20.0 0.5 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch P53_TAD PF08563.6 ESA17824.1 - 0.81 8.8 2.7 0.84 8.7 0.4 2.1 2 0 0 2 2 2 0 P53 transactivation motif DUF883 PF05957.8 ESA17825.1 - 8.5e-06 26.0 16.6 0.013 15.8 4.1 3.4 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) YtxH PF12732.2 ESA17825.1 - 0.00033 20.9 33.6 0.3 11.4 3.1 3.9 1 1 2 3 3 3 2 YtxH-like protein V-SNARE_C PF12352.3 ESA17825.1 - 0.012 15.6 8.4 0.025 14.6 0.5 4.0 3 2 1 4 4 4 0 Snare region anchored in the vesicle membrane C-terminus SAB PF04382.8 ESA17825.1 - 0.065 12.9 1.2 0.14 11.8 0.1 2.2 2 0 0 2 2 2 0 SAB domain Apolipoprotein PF01442.13 ESA17825.1 - 0.087 12.3 16.9 0.67 9.4 11.7 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HisKA_3 PF07730.8 ESA17825.1 - 0.14 12.5 5.8 14 6.1 0.4 3.7 1 1 3 4 4 4 0 Histidine kinase DUF3708 PF12501.3 ESA17825.1 - 0.24 11.2 5.6 2.2 8.0 0.5 2.1 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter ATP-synt_B PF00430.13 ESA17825.1 - 0.34 10.7 29.5 0.57 9.9 6.5 3.3 1 1 3 4 4 4 0 ATP synthase B/B' CF(0) Baculo_p24 PF05073.7 ESA17825.1 - 0.53 9.8 10.1 0.17 11.3 4.7 1.8 1 1 1 2 2 2 0 Baculovirus P24 capsid protein LEA_4 PF02987.11 ESA17825.1 - 0.68 9.8 23.5 0.94 9.4 0.4 3.8 2 1 1 3 3 3 0 Late embryogenesis abundant protein DUF3078 PF11276.3 ESA17825.1 - 3.3 7.9 9.4 9.5 6.4 0.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3078) Muted PF14942.1 ESA17825.1 - 4.6 7.1 19.1 1 9.2 7.9 2.2 1 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF2229 PF09989.4 ESA17825.1 - 4.8 6.5 18.0 77 2.6 8.0 3.0 1 1 2 3 3 3 0 CoA enzyme activase uncharacterised domain (DUF2229) Peptidase_S64 PF08192.6 ESA17825.1 - 5.1 5.3 18.7 5.9 5.0 13.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Oest_recep PF02159.10 ESA17825.1 - 6.4 6.8 16.1 2.5 8.2 3.1 2.8 2 1 1 3 3 3 0 Oestrogen receptor DEAD PF00270.24 ESA17826.1 - 4.1e-34 117.4 1.6 6e-33 113.7 0.3 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA17826.1 - 8e-25 86.5 0.1 1.4e-24 85.7 0.1 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 ESA17826.1 - 0.041 13.8 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Helicase C-terminal domain AAA_30 PF13604.1 ESA17826.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA17826.1 - 0.12 12.4 0.6 0.63 10.1 0.3 2.4 2 1 0 2 2 2 0 AAA domain PALP PF00291.20 ESA17827.1 - 2e-57 194.7 0.0 2.5e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NuiA PF07924.6 ESA17827.1 - 0.077 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Tctex-1 PF03645.8 ESA17828.1 - 7.9e-29 99.4 2.3 9.5e-29 99.2 1.6 1.1 1 0 0 1 1 1 1 Tctex-1 family Dioxygenase_C PF00775.16 ESA17828.1 - 0.021 14.1 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Dioxygenase Clathrin PF00637.15 ESA17828.1 - 0.03 13.9 0.1 0.043 13.4 0.1 1.2 1 0 0 1 1 1 0 Region in Clathrin and VPS TIMP PF00965.12 ESA17828.1 - 0.031 13.8 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase DnaB_2 PF07261.6 ESA17828.1 - 0.061 12.9 0.3 0.1 12.2 0.1 1.5 1 1 0 1 1 1 0 Replication initiation and membrane attachment Fork_head PF00250.13 ESA17828.1 - 0.13 12.3 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Fork head domain G-alpha PF00503.15 ESA17829.1 - 1.5e-130 435.4 2.3 1.8e-130 435.1 1.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 ESA17829.1 - 1.5e-16 60.0 0.4 3.3e-11 42.7 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.15 ESA17829.1 - 0.00017 21.0 0.1 0.00065 19.1 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger Miro PF08477.8 ESA17829.1 - 0.00058 20.3 0.1 1.5 9.3 0.0 2.8 2 1 0 2 2 2 2 Miro-like protein Gtr1_RagA PF04670.7 ESA17829.1 - 0.0022 17.2 4.0 0.094 11.8 0.0 2.7 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 ESA17829.1 - 0.013 14.9 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.22 ESA17829.1 - 0.025 13.9 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.13 ESA17829.1 - 0.06 12.8 0.0 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 ESA17829.1 - 0.062 13.2 0.2 2.3 8.2 0.1 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase CSTF_C PF14304.1 ESA17830.1 - 1.1e-08 34.1 8.8 1.1e-08 34.1 6.1 3.2 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.1 ESA17830.1 - 2.4e-08 33.9 1.3 2.4e-08 33.9 0.9 4.0 2 1 1 4 4 4 1 Hinge domain of cleavage stimulation factor subunit 2 SOBP PF15279.1 ESA17830.1 - 0.0045 17.4 14.9 0.0069 16.8 10.3 1.2 1 1 0 1 1 1 1 Sine oculis-binding protein RA PF00788.18 ESA17830.1 - 0.18 12.2 3.9 0.14 12.6 1.3 1.9 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Metal_resist PF13801.1 ESA17830.1 - 0.38 10.7 7.6 9.2 6.2 4.5 2.5 2 0 0 2 2 2 0 Heavy-metal resistance DUF2919 PF11143.3 ESA17831.1 - 0.011 15.5 0.7 0.011 15.5 0.5 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2919) Glycogen_syn PF05693.8 ESA17832.1 - 0 1018.1 0.0 0 1017.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_5 PF08323.6 ESA17832.1 - 1.1e-08 34.9 0.7 3.3e-08 33.3 0.5 1.8 1 1 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 ESA17832.1 - 5.6e-07 29.1 0.0 1.5e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 ESA17832.1 - 5.4e-06 26.6 0.1 1.2e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Pkinase_Tyr PF07714.12 ESA17833.1 - 5.2e-41 140.4 0.0 6.9e-41 140.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17833.1 - 9.3e-33 113.4 0.0 1.3e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain TRA-1_regulated PF02343.11 ESA17833.1 - 0.0021 17.5 0.1 0.0047 16.4 0.1 1.6 1 0 0 1 1 1 1 TRA-1 regulated protein R03H10.4 Kdo PF06293.9 ESA17833.1 - 0.021 13.9 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA17834.1 - 2.3e-25 89.2 0.0 3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17834.1 - 2e-21 76.2 0.0 2.9e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA17834.1 - 3.8e-05 23.1 0.2 0.00035 19.9 0.0 2.0 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA17834.1 - 0.00019 21.2 0.2 0.00027 20.7 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RNA_pol_Rpb1_6 PF04992.9 ESA17834.1 - 0.036 13.7 0.2 0.096 12.4 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 6 Kdo PF06293.9 ESA17834.1 - 0.039 13.0 0.1 0.058 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Alpha_kinase PF02816.13 ESA17835.1 - 6.6e-16 58.5 0.0 1.3e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA17835.1 - 7.1e-06 26.2 0.0 9.5e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain OrfB_Zn_ribbon PF07282.6 ESA17836.1 - 0.17 11.5 1.6 0.33 10.6 1.1 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF3319 PF11782.3 ESA17837.1 - 0.0051 16.5 0.2 0.0069 16.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3319) BLOC1_2 PF10046.4 ESA17837.1 - 0.029 14.5 2.6 0.029 14.5 1.8 1.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3294 PF07957.6 ESA17837.1 - 0.03 13.8 5.7 0.059 12.9 3.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3294) KBP_C PF12309.3 ESA17837.1 - 0.048 12.6 1.0 0.058 12.3 0.7 1.1 1 0 0 1 1 1 0 KIF-1 binding protein C terminal OmpH PF03938.9 ESA17837.1 - 0.16 11.9 6.3 0.16 11.8 4.4 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Syntaxin-6_N PF09177.6 ESA17837.1 - 0.21 12.0 4.9 0.28 11.5 3.4 1.3 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Maelstrom PF13017.1 ESA17837.1 - 0.23 10.9 1.6 0.24 10.8 1.1 1.1 1 0 0 1 1 1 0 piRNA pathway germ-plasm component BAF1_ABF1 PF04684.8 ESA17837.1 - 0.42 9.4 4.7 0.39 9.5 3.3 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LIM_bind PF01803.11 ESA17837.1 - 0.51 9.4 7.0 0.62 9.1 4.8 1.0 1 0 0 1 1 1 0 LIM-domain binding protein TMPIT PF07851.8 ESA17837.1 - 0.58 9.1 4.1 0.59 9.1 2.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein M_domain PF12938.2 ESA17837.1 - 0.9 9.3 18.2 13 5.4 11.9 2.0 1 1 1 2 2 2 0 M domain of GW182 IFT57 PF10498.4 ESA17837.1 - 1.1 7.8 7.9 1.3 7.6 5.5 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Rogdi_lz PF10259.4 ESA17837.1 - 2.1 7.3 6.3 2.1 7.3 4.4 1.0 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein PTRF_SDPR PF15237.1 ESA17837.1 - 3 7.1 9.5 12 5.2 7.1 1.6 1 1 1 2 2 2 0 PTRF/SDPR family Suppressor_APC PF11414.3 ESA17837.1 - 4 7.2 9.4 5.7 6.8 5.3 1.9 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Endonuclease_7 PF02945.10 ESA17838.1 - 0.011 15.4 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Recombination endonuclease VII zf-C3HC4_2 PF13923.1 ESA17838.1 - 0.021 14.8 0.5 1.3 9.0 0.4 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase_Tyr PF07714.12 ESA17839.1 - 8.4e-49 165.9 0.0 1.3e-48 165.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17839.1 - 2.4e-48 164.5 0.0 4.6e-48 163.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA17839.1 - 2e-17 63.1 1.6 4.8e-06 27.0 0.0 3.7 3 0 0 3 3 3 3 Sel1 repeat Kdo PF06293.9 ESA17839.1 - 0.0011 18.0 0.5 0.011 14.8 0.0 2.7 4 0 0 4 4 4 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA17839.1 - 0.0048 16.6 0.0 0.0083 15.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESA17840.1 - 1.9e-06 27.2 0.0 2.3e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA17840.1 - 0.0096 15.0 0.0 0.012 14.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA17840.1 - 0.029 13.3 0.0 0.034 13.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like p450 PF00067.17 ESA17842.1 - 3.4e-31 108.2 0.0 3.8e-31 108.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA17842.1 - 0.068 13.1 0.1 0.17 11.8 0.1 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1811) Tcp10_C PF07202.8 ESA17842.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 T-complex protein 10 C-terminus N-SET PF11764.3 ESA17842.1 - 0.26 11.1 1.2 0.39 10.6 0.8 1.3 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N Spt20 PF12090.3 ESA17843.1 - 0.022 14.1 0.1 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Spt20 family F-box PF00646.28 ESA17845.1 - 0.016 14.8 1.3 0.016 14.8 0.9 2.8 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.2 ESA17845.1 - 0.016 14.9 0.7 0.016 14.9 0.5 1.8 2 0 0 2 2 2 0 F-box-like Eaf7 PF07904.8 ESA17845.1 - 0.082 12.8 1.7 0.14 12.1 0.1 2.2 3 0 0 3 3 3 0 Chromatin modification-related protein EAF7 Pkinase_Tyr PF07714.12 ESA17846.1 - 1.9e-23 82.8 0.4 1.3e-18 66.9 0.1 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA17846.1 - 1.7e-20 73.2 5.5 3.4e-16 59.1 0.1 3.1 2 1 1 3 3 3 2 Protein kinase domain TRA-1_regulated PF02343.11 ESA17846.1 - 0.012 15.1 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 TRA-1 regulated protein R03H10.4 DUF4239 PF14023.1 ESA17846.1 - 0.039 13.3 6.4 0.24 10.7 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4239) AAA_31 PF13614.1 ESA17846.1 - 0.74 9.7 5.0 3.5 7.5 0.1 3.2 1 1 2 3 3 3 0 AAA domain AAA_16 PF13191.1 ESA17849.1 - 0.061 13.3 0.0 0.29 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 ESA17849.1 - 0.17 11.9 0.9 4.5 7.4 0.6 2.6 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESA17849.1 - 0.18 12.6 2.6 9 7.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF565 PF04483.7 ESA17850.1 - 0.24 11.6 5.7 0.064 13.4 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF565) Peptidase_M20 PF01546.23 ESA17852.1 - 3.4e-10 39.7 0.0 5.5e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 ESA17852.1 - 1.5e-06 27.9 0.0 3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain F-box-like PF12937.2 ESA17853.1 - 7.5e-05 22.3 0.9 0.00025 20.7 0.6 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA17853.1 - 0.12 12.0 0.2 0.12 12.0 0.1 4.4 1 1 1 3 3 3 0 Leucine Rich repeats (2 copies) TLD PF07534.11 ESA17856.1 - 0.00042 20.3 0.3 0.00062 19.7 0.2 1.3 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA17857.1 - 8.5e-19 67.5 0.1 1.6e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA17857.1 - 0.00028 20.6 4.0 0.00066 19.4 1.2 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch FemAB PF02388.11 ESA17859.1 - 0.13 10.9 1.3 0.15 10.7 0.9 1.0 1 0 0 1 1 1 0 FemAB family LAT PF15234.1 ESA17859.1 - 0.28 10.6 1.5 0.3 10.5 1.0 1.0 1 0 0 1 1 1 0 Linker for activation of T-cells DUF4136 PF13590.1 ESA17861.1 - 0.09 12.8 0.1 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4136) MSA-2c PF12238.3 ESA17861.1 - 5.4 6.6 8.1 0.79 9.3 0.7 2.3 2 0 0 2 2 2 0 Merozoite surface antigen 2c VASP_tetra PF08776.6 ESA17863.1 - 0.16 11.3 2.5 0.18 11.1 0.5 2.0 2 0 0 2 2 2 0 VASP tetramerisation domain DUF4519 PF15012.1 ESA17864.1 - 2.1 8.3 8.2 1.7 8.6 1.4 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) PMEI PF04043.10 ESA17866.1 - 0.0003 20.7 0.1 0.00042 20.2 0.0 1.2 1 0 0 1 1 1 1 Plant invertase/pectin methylesterase inhibitor MCPsignal PF00015.16 ESA17866.1 - 0.00067 19.2 0.2 0.00087 18.8 0.2 1.1 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain ACP53EA PF06313.6 ESA17866.1 - 0.083 12.8 0.9 0.64 9.9 0.6 2.1 1 1 0 1 1 1 0 Drosophila ACP53EA protein DUF2990 PF11693.3 ESA17866.1 - 0.26 11.1 1.8 0.62 9.9 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) DUF3926 PF13080.1 ESA17866.1 - 0.4 10.2 3.8 1.3 8.6 0.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3926) zf-RING_2 PF13639.1 ESA17868.1 - 0.00034 20.3 0.3 0.00053 19.7 0.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA17868.1 - 0.0076 16.3 0.1 0.0091 16.0 0.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA17868.1 - 0.11 12.1 1.7 0.19 11.4 1.2 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA17868.1 - 0.12 12.4 1.2 0.14 12.2 0.4 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3422 PF11902.3 ESA17873.1 - 0.21 10.4 0.0 0.37 9.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) DUF3116 PF11313.3 ESA17874.1 - 0.055 13.0 1.1 0.096 12.3 0.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3116) OmpH PF03938.9 ESA17875.1 - 0.0028 17.6 2.2 0.0028 17.6 1.6 3.5 1 1 2 3 3 3 1 Outer membrane protein (OmpH-like) DUF724 PF05266.9 ESA17875.1 - 0.005 16.4 17.9 0.005 16.4 12.4 3.5 1 1 2 3 3 3 1 Protein of unknown function (DUF724) CENP-F_leu_zip PF10473.4 ESA17875.1 - 0.14 11.9 68.1 0.035 13.9 19.2 3.9 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 ESA17875.1 - 4.3 6.8 67.5 3.6 7.1 5.9 3.1 1 1 2 3 3 3 0 IncA protein DUF3584 PF12128.3 ESA17875.1 - 6.3 3.9 47.2 9.1 3.4 32.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) OmpH PF03938.9 ESA17876.1 - 0.0009 19.2 1.7 0.0009 19.2 1.1 4.3 1 1 2 3 3 3 1 Outer membrane protein (OmpH-like) CENP-F_leu_zip PF10473.4 ESA17877.1 - 0.001 18.9 36.3 0.001 18.9 25.2 4.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF724 PF05266.9 ESA17877.1 - 0.011 15.3 15.6 0.011 15.3 10.8 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Reo_sigmaC PF04582.7 ESA17877.1 - 4.1 6.4 16.1 0.28 10.3 3.1 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein AHSP PF09236.5 ESA17877.1 - 9.4 6.5 18.2 0.3 11.3 0.5 3.7 2 2 1 3 3 3 0 Alpha-haemoglobin stabilising protein DUF3184 PF11380.3 ESA17878.1 - 0.43 8.4 1.9 0.73 7.6 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3184) CENP-F_leu_zip PF10473.4 ESA17878.1 - 3.8 7.3 90.7 0.02 14.7 21.8 4.8 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sod_Fe_C PF02777.13 ESA17879.1 - 7.1e-24 83.6 0.3 2.6e-12 46.5 0.0 2.2 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Ribosomal_L50 PF10501.4 ESA17880.1 - 1.9e-08 34.2 1.0 5e-08 32.9 0.7 1.8 1 1 0 1 1 1 1 Ribosomal subunit 39S TLD PF07534.11 ESA17881.1 - 4.7e-13 49.3 0.2 5.9e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 TLD PHD_2 PF13831.1 ESA17881.1 - 0.09 12.1 0.2 0.23 10.7 0.1 1.7 1 0 0 1 1 1 0 PHD-finger Mg_trans_NIPA PF05653.9 ESA17882.1 - 1.2e-17 63.8 23.3 2e-09 36.8 7.6 2.4 2 1 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA17882.1 - 0.00067 19.8 6.7 0.00067 19.8 4.7 3.2 3 1 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA17882.1 - 0.012 15.6 9.2 0.012 15.6 6.4 4.1 2 2 1 3 3 3 0 EamA-like transporter family ACDC PF14733.1 ESA17884.1 - 0.12 12.5 1.6 0.17 11.9 0.1 2.0 1 1 1 2 2 2 0 AP2-coincident C-terminal Tfb2 PF03849.9 ESA17886.1 - 3.1e-119 397.9 5.1 6.3e-61 206.0 0.0 2.2 1 1 1 2 2 2 2 Transcription factor Tfb2 Helicase_C_3 PF13625.1 ESA17886.1 - 9.3e-06 25.4 0.0 2.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HTH_45 PF14947.1 ESA17886.1 - 0.046 13.5 0.1 9.5 6.1 0.0 2.7 2 0 0 2 2 2 0 Winged helix-turn-helix Asn_synthase PF00733.16 ESA17887.1 - 3.6e-69 233.1 0.0 5.2e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 ESA17887.1 - 1.3e-40 137.9 0.0 3.2e-40 136.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 ESA17887.1 - 3.7e-33 114.3 0.0 7.5e-33 113.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.3 ESA17887.1 - 1.3e-08 34.3 0.0 2.2e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 ESA17887.1 - 0.00031 19.5 0.0 0.017 13.8 0.0 2.1 1 1 1 2 2 2 2 Glutamine amidotransferases class-II NAD_synthase PF02540.12 ESA17887.1 - 0.015 14.2 0.0 0.021 13.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase QueC PF06508.8 ESA17887.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC SHD1 PF03983.7 ESA17888.1 - 3.1e-33 113.2 0.0 6.3e-33 112.2 0.0 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 Pkinase_Tyr PF07714.12 ESA17889.1 - 2e-44 151.6 0.0 2.8e-44 151.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17889.1 - 9.4e-44 149.4 0.1 3e-43 147.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain PsbU PF06514.6 ESA17889.1 - 0.0018 18.0 0.0 0.0063 16.3 0.0 1.9 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) DUF3126 PF11324.3 ESA17889.1 - 0.043 13.4 0.2 0.15 11.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3126) DUF1641 PF07849.6 ESA17889.1 - 0.096 12.3 0.0 5.1 6.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1641) HMG_box PF00505.14 ESA17892.1 - 4e-06 27.0 1.3 1e-05 25.6 0.9 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA17892.1 - 0.00012 22.4 1.0 0.00021 21.5 0.7 1.4 1 0 0 1 1 1 1 HMG-box domain Leu_zip PF15294.1 ESA17893.1 - 0.00015 20.9 1.8 0.00015 20.9 1.3 1.0 1 0 0 1 1 1 1 Leucine zipper HALZ PF02183.13 ESA17893.1 - 0.0067 16.1 3.6 0.083 12.6 2.5 2.2 1 1 0 1 1 1 1 Homeobox associated leucine zipper bZIP_1 PF00170.16 ESA17893.1 - 0.017 15.0 1.7 0.022 14.7 1.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor CtIP_N PF10482.4 ESA17893.1 - 0.017 14.9 0.5 0.019 14.7 0.4 1.0 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain NYD-SP28_assoc PF14775.1 ESA17893.1 - 0.023 14.3 0.7 0.048 13.3 0.5 1.7 1 1 0 1 1 1 0 Sperm tail C-terminal domain DUF972 PF06156.8 ESA17893.1 - 0.07 13.4 0.4 0.074 13.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) HHH_3 PF12836.2 ESA17893.1 - 0.098 12.6 0.3 0.15 12.0 0.2 1.4 1 1 0 1 1 1 0 Helix-hairpin-helix motif bZIP_2 PF07716.10 ESA17893.1 - 0.099 12.4 2.4 1.1 9.1 0.2 2.1 1 1 1 2 2 2 0 Basic region leucine zipper Fes1 PF08609.5 ESA17893.1 - 0.11 12.9 0.1 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Nucleotide exchange factor Fes1 DUF904 PF06005.7 ESA17893.1 - 0.18 12.1 1.5 0.21 11.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DivIC PF04977.10 ESA17893.1 - 0.22 11.0 1.0 0.34 10.4 0.7 1.6 1 1 0 1 1 1 0 Septum formation initiator RICH PF05062.7 ESA17893.1 - 0.26 11.4 3.0 0.28 11.3 2.1 1.1 1 0 0 1 1 1 0 RICH domain Pkinase_Tyr PF07714.12 ESA17895.1 - 6.9e-28 97.4 0.0 1.4e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17895.1 - 4.3e-25 88.3 0.1 7.8e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain PHD PF00628.24 ESA17895.1 - 0.88 9.3 16.5 1.9 8.2 11.4 1.6 1 0 0 1 1 1 0 PHD-finger Pkinase_Tyr PF07714.12 ESA17896.1 - 2.3e-18 66.2 1.7 2.3e-18 66.2 1.2 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA17896.1 - 5.8e-17 61.7 5.2 5.8e-17 61.7 3.6 1.5 2 0 0 2 2 2 1 Protein kinase domain zf-B_box PF00643.19 ESA17896.1 - 0.032 14.1 1.8 0.032 14.1 1.3 3.5 3 0 0 3 3 3 0 B-box zinc finger APH PF01636.18 ESA17896.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family stn_TNFRSF12A PF12191.3 ESA17896.1 - 0.49 10.4 12.5 1.4 8.9 1.7 2.3 1 1 1 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Sensor PF13796.1 ESA17897.1 - 2.3e-05 24.0 3.9 0.0028 17.3 3.1 2.3 1 1 1 2 2 2 2 Putative sensor DUF2963 PF11178.3 ESA17897.1 - 9.6 5.7 8.4 5.4 6.5 3.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) VirC1 PF07015.6 ESA17898.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 VirC1 protein BRCA2 PF00634.13 ESA17899.1 - 0.008 15.4 0.6 0.023 13.9 0.4 1.8 1 0 0 1 1 1 1 BRCA2 repeat SAC3 PF12209.3 ESA17899.1 - 0.095 12.8 1.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain AAA PF00004.24 ESA17900.1 - 9.4e-06 25.8 0.6 0.00025 21.2 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA17900.1 - 4.2e-05 23.3 0.0 9.7e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 ESA17900.1 - 0.00037 20.3 0.2 0.0016 18.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA17900.1 - 0.00075 19.6 0.0 0.0064 16.6 0.0 2.5 3 0 0 3 3 3 1 AAA domain Miro PF08477.8 ESA17900.1 - 0.00085 19.8 0.0 0.0028 18.1 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein NACHT PF05729.7 ESA17900.1 - 0.0097 15.5 0.4 0.11 12.2 0.0 2.8 3 0 0 3 3 3 1 NACHT domain Sigma54_activ_2 PF14532.1 ESA17900.1 - 0.014 15.4 0.0 0.045 13.8 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.13 ESA17900.1 - 0.031 13.8 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 ESA17900.1 - 0.033 14.3 0.0 0.19 11.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase T2SE PF00437.15 ESA17900.1 - 0.068 12.0 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PduV-EutP PF10662.4 ESA17900.1 - 0.099 12.1 0.0 4.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF3981 PF13139.1 ESA17903.1 - 0.13 12.2 0.2 0.13 12.2 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3981) Pox_A3L PF05288.6 ESA17904.1 - 0.16 11.7 5.0 3.7 7.3 0.2 3.3 3 0 0 3 3 3 0 Poxvirus A3L Protein TLD PF07534.11 ESA17906.1 - 1.4e-15 57.5 3.2 2.1e-15 56.9 2.2 1.3 1 0 0 1 1 1 1 TLD GATase_2 PF00310.16 ESA17907.1 - 1.1e-25 90.1 0.1 5.9e-21 74.5 0.0 2.2 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 ESA17907.1 - 5.1e-16 58.8 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 ESA17907.1 - 2.7e-13 49.7 0.0 7.3e-13 48.3 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 ESA17907.1 - 5.5e-12 45.5 0.1 1e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 ESA17907.1 - 1.4e-05 23.9 0.0 2.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II LcnG-beta PF11632.3 ESA17909.1 - 0.002 17.8 0.3 0.0031 17.2 0.2 1.3 1 0 0 1 1 1 1 Lactococcin G-beta Activator-TraM PF11657.3 ESA17911.1 - 0.0044 16.5 0.4 0.0078 15.7 0.2 1.3 1 0 0 1 1 1 1 Transcriptional activator TraM YjcZ PF13990.1 ESA17911.1 - 0.017 14.2 0.7 0.046 12.8 0.3 1.9 1 1 0 1 1 1 0 YjcZ-like protein Mitofilin PF09731.4 ESA17911.1 - 0.046 12.3 3.0 0.066 11.8 2.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Phasin PF05597.6 ESA17911.1 - 0.055 13.2 0.9 0.54 10.0 0.2 2.3 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Ovate PF04844.8 ESA17911.1 - 0.11 12.2 2.5 0.3 10.8 0.3 2.7 1 1 1 2 2 2 0 Transcriptional repressor, ovate Baculo_PEP_C PF04513.7 ESA17911.1 - 0.24 11.2 6.7 0.39 10.5 0.8 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 ESA17911.1 - 0.74 9.9 9.1 0.27 11.3 3.6 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AAA_5 PF07728.9 ESA17913.1 - 4.2e-06 26.5 0.0 6.8e-05 22.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA17913.1 - 4e-05 23.8 0.0 0.01 16.0 0.0 3.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESA17913.1 - 0.00035 20.4 0.4 0.024 14.5 0.0 3.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA17913.1 - 0.00064 19.8 0.2 0.08 13.0 0.0 4.4 5 1 1 6 6 6 1 AAA domain Miro PF08477.8 ESA17913.1 - 0.0019 18.6 0.0 0.0077 16.7 0.0 2.1 1 0 0 1 1 1 1 Miro-like protein Sigma54_activ_2 PF14532.1 ESA17913.1 - 0.02 14.9 0.0 0.56 10.2 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain B-block_TFIIIC PF04182.7 ESA17913.1 - 0.026 14.3 0.4 0.093 12.5 0.3 1.9 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC AAA_16 PF13191.1 ESA17913.1 - 0.15 12.0 0.0 0.62 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain F-box-like PF12937.2 ESA17914.1 - 0.00014 21.4 1.6 0.00031 20.4 1.1 1.6 1 1 0 1 1 1 1 F-box-like PRANC PF09372.5 ESA17914.1 - 1.6 8.7 6.7 0.84 9.6 1.3 2.4 2 2 0 2 2 2 0 PRANC domain TPR_11 PF13414.1 ESA17917.1 - 2.9e-37 126.1 12.6 1.6e-09 37.2 0.3 5.5 2 1 1 5 5 5 5 TPR repeat TPR_2 PF07719.12 ESA17917.1 - 4.6e-32 107.3 3.3 0.0068 16.2 0.0 9.3 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.23 ESA17917.1 - 7.4e-32 107.6 8.2 0.00032 20.1 0.0 9.1 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17917.1 - 3.7e-20 70.1 4.5 0.016 14.9 0.0 7.4 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_9 PF13371.1 ESA17917.1 - 3.9e-19 68.2 2.8 5.1e-06 26.2 0.0 5.7 1 1 4 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17917.1 - 8.1e-17 61.4 7.0 0.0003 21.3 0.0 5.3 2 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17917.1 - 2.1e-13 49.9 13.3 0.00027 20.8 0.4 5.0 1 1 6 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17917.1 - 1.9e-11 43.2 6.9 0.3 11.3 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA17917.1 - 7.2e-10 39.0 5.0 0.018 15.3 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA17917.1 - 8.5e-09 34.5 2.1 1 8.6 0.0 5.9 5 0 0 5 5 5 3 SHNi-TPR TPR_14 PF13428.1 ESA17917.1 - 3.6e-06 27.1 7.9 4.8 8.1 0.1 7.3 1 1 7 8 8 8 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA17917.1 - 6.7e-06 26.1 5.7 0.56 10.3 0.1 4.1 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESA17917.1 - 0.0013 18.3 3.1 5.1 7.1 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA17917.1 - 0.024 15.0 5.7 29 5.4 0.0 5.8 7 0 0 7 7 6 0 Tetratricopeptide repeat Pept_tRNA_hydro PF01195.14 ESA17918.1 - 6e-39 133.4 0.0 1.4e-38 132.2 0.0 1.5 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase Y_phosphatase PF00102.22 ESA17919.1 - 1.1e-06 28.2 0.0 2.1e-06 27.2 0.0 1.4 1 1 1 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.15 ESA17919.1 - 4.8e-05 22.9 0.0 5.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain NADH_B2 PF14813.1 ESA17920.1 - 0.017 14.7 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 Ribosomal_L32e PF01655.13 ESA17921.1 - 4e-50 168.4 2.2 4.9e-50 168.1 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 DCP1 PF06058.8 ESA17922.1 - 1.3e-27 96.2 0.0 1.6e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Dcp1-like decapping family PI31_Prot_N PF11566.3 ESA17923.1 - 0.033 13.7 13.1 0.12 11.9 1.4 2.6 2 1 0 2 2 2 0 PI31 proteasome regulator N-terminal PaO PF08417.7 ESA17923.1 - 0.041 13.8 0.0 0.44 10.4 0.0 2.4 2 0 0 2 2 2 0 Pheophorbide a oxygenase Sas10 PF09368.5 ESA17924.1 - 1.4e-29 102.0 8.4 1.4e-29 102.0 5.9 2.7 3 0 0 3 3 3 1 Sas10 C-terminal domain phiKZ_IP PF12699.2 ESA17925.1 - 0.0061 15.5 0.1 0.0067 15.3 0.1 1.0 1 0 0 1 1 1 1 phiKZ-like phage internal head proteins Sigma70_ner PF04546.8 ESA17925.1 - 0.029 13.9 0.3 0.031 13.8 0.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region F-box PF00646.28 ESA17926.1 - 4.2e-07 29.4 0.0 8.5e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA17926.1 - 4.1e-05 23.2 0.0 7.6e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like Med15 PF09606.5 ESA17926.1 - 0.023 12.8 18.5 0.029 12.6 12.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Band_3_cyto PF07565.8 ESA17926.1 - 0.55 9.7 7.9 0.9 9.0 5.4 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain BAF1_ABF1 PF04684.8 ESA17926.1 - 0.7 8.6 21.9 1.2 7.9 15.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF4175 PF13779.1 ESA17926.1 - 1.5 6.4 21.4 2 5.9 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Serinc PF03348.10 ESA17926.1 - 1.9 7.0 5.0 2.8 6.5 3.5 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) ATP-synt_E PF05680.7 ESA17926.1 - 6.4 6.8 12.1 14 5.6 8.4 1.5 1 0 0 1 1 1 0 ATP synthase E chain rve_2 PF13333.1 ESA17927.1 - 0.042 13.9 4.1 2.5 8.2 0.0 3.5 3 0 0 3 3 3 0 Integrase core domain DUF770 PF05591.7 ESA17927.1 - 0.043 13.3 1.1 0.42 10.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF770) DUF4083 PF13314.1 ESA17927.1 - 5.4 6.9 7.5 0.77 9.6 0.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) DUF3365 PF11845.3 ESA17930.1 - 0.58 9.9 3.7 0.25 11.1 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) RIIa PF02197.12 ESA17930.1 - 5 6.6 6.3 11 5.5 0.2 3.3 3 0 0 3 3 3 0 Regulatory subunit of type II PKA R-subunit NSP2_assoc PF14758.1 ESA17931.1 - 0.05 13.7 1.0 0.061 13.4 0.7 1.1 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein Suf PF05843.9 ESA17931.1 - 1.8 8.2 6.2 2.2 7.9 4.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hist_deacetyl PF00850.14 ESA17932.1 - 1.5e-65 221.5 0.0 1.7e-65 221.3 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain F-box-like PF12937.2 ESA17933.1 - 0.0013 18.3 2.0 0.0016 18.1 0.7 1.6 2 0 0 2 2 2 1 F-box-like RE_SinI PF09570.5 ESA17934.1 - 0.015 14.3 0.1 0.021 13.8 0.1 1.3 1 1 0 1 1 1 0 SinI restriction endonuclease Zea_mays_MuDR PF05928.6 ESA17935.1 - 0.03 13.7 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) LRR_1 PF00560.28 ESA17936.1 - 0.083 12.9 8.8 2.5 8.4 0.1 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.2 ESA17936.1 - 0.12 12.0 0.2 0.12 12.0 0.1 3.6 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Ogr_Delta PF04606.7 ESA17937.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger Copine PF07002.11 ESA17939.1 - 2.9e-33 114.6 0.1 8.9e-33 113.0 0.0 1.8 2 0 0 2 2 2 1 Copine C2 PF00168.25 ESA17939.1 - 9.1e-08 31.8 0.6 0.00017 21.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.4 ESA17939.1 - 5.6e-06 26.3 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_2 PF13519.1 ESA17939.1 - 0.0046 17.0 0.0 0.0063 16.6 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain SLX9 PF15341.1 ESA17943.1 - 9.8e-19 67.9 19.9 1.6e-18 67.3 13.8 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Neur_chan_memb PF02932.11 ESA17943.1 - 2.4 7.9 13.4 3.1 7.6 8.7 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RNA_pol_Rpb1_5 PF04998.12 ESA17943.1 - 4.7 6.3 10.3 6.5 5.9 7.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Sel1 PF08238.7 ESA17944.1 - 8e-45 150.2 50.7 1.3e-05 25.7 0.1 13.6 14 0 0 14 14 14 10 Sel1 repeat DUF1183 PF06682.7 ESA17944.1 - 0.0028 17.3 0.1 0.0055 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) TPR_11 PF13414.1 ESA17944.1 - 0.042 13.5 0.1 0.057 13.0 0.1 6.0 6 1 2 8 8 8 0 TPR repeat TPR_16 PF13432.1 ESA17944.1 - 0.049 14.3 27.5 0.04 14.5 1.2 6.8 6 2 1 7 7 7 0 Tetratricopeptide repeat Ribosom_S12_S23 PF00164.20 ESA17945.1 - 2.6e-41 139.8 0.9 3e-41 139.6 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 TH1 PF04858.8 ESA17946.1 - 5.4e-36 123.9 0.0 6.8e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 TH1 protein DUF4252 PF14060.1 ESA17951.1 - 0.061 12.8 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) NUDIX PF00293.23 ESA17955.1 - 1.9e-11 43.7 0.0 1.5e-10 40.8 0.0 2.1 1 1 0 1 1 1 1 NUDIX domain Topoisom_bac PF01131.15 ESA17955.1 - 0.11 11.2 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 DNA topoisomerase HEAT_EZ PF13513.1 ESA17957.1 - 2.1e-05 24.8 11.4 0.037 14.5 0.0 5.6 5 2 2 7 7 7 3 HEAT-like repeat HEAT PF02985.17 ESA17957.1 - 0.0022 17.9 3.7 0.025 14.6 0.0 4.1 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.1 ESA17957.1 - 0.0039 17.4 0.2 0.069 13.4 0.0 3.1 2 2 1 3 3 3 1 HEAT repeats DUF2435 PF10363.4 ESA17957.1 - 0.017 14.9 0.1 0.22 11.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2435) DUF4570 PF15134.1 ESA17958.1 - 1 9.2 7.0 0.19 11.6 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Smg4_UPF3 PF03467.10 ESA17959.1 - 0.041 13.8 3.5 0.048 13.6 2.4 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family HR1 PF02185.11 ESA17959.1 - 0.06 13.0 4.0 0.085 12.6 2.8 1.3 1 0 0 1 1 1 0 Hr1 repeat DUF883 PF05957.8 ESA17959.1 - 0.093 13.1 0.9 0.13 12.6 0.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) SDH_beta PF03315.10 ESA17959.1 - 0.14 12.1 0.4 0.16 12.0 0.3 1.2 1 0 0 1 1 1 0 Serine dehydratase beta chain ATP-synt_DE PF00401.15 ESA17959.1 - 0.21 11.4 4.4 0.35 10.7 3.1 1.3 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF2533 PF10752.4 ESA17959.1 - 0.4 11.0 6.3 0.11 12.7 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2533) F-box-like PF12937.2 ESA17960.1 - 0.005 16.5 0.1 0.011 15.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.1 ESA17960.1 - 0.9 9.7 14.9 43 4.6 0.0 7.1 7 1 0 7 7 7 0 Leucine Rich repeat zf-H2C2_2 PF13465.1 ESA17961.1 - 7.4e-21 73.3 20.3 4.8e-07 29.7 1.5 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.21 ESA17961.1 - 1.4e-20 72.3 21.0 2.3e-05 24.4 0.6 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA17961.1 - 2.3e-14 52.5 18.5 0.0023 18.1 0.4 4.1 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA17961.1 - 2.1e-05 24.4 7.9 0.7 10.1 0.1 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA17961.1 - 0.00015 21.8 2.5 3.8 7.8 0.0 4.5 3 1 2 5 5 5 2 Zinc-finger of C2H2 type zf-TRAF PF02176.13 ESA17961.1 - 0.084 13.2 10.3 0.12 12.7 2.4 2.7 2 1 1 3 3 3 0 TRAF-type zinc finger DUF629 PF04780.7 ESA17961.1 - 0.55 8.6 7.3 4 5.8 0.1 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF629) zf-CGNR PF11706.3 ESA17961.1 - 1.4 8.4 8.0 7.1 6.2 0.1 3.8 4 0 0 4 4 4 0 CGNR zinc finger CHORD PF04968.7 ESA17961.1 - 3.4 7.9 13.9 6.3 7.1 0.3 3.8 1 1 3 4 4 4 0 CHORD S1-P1_nuclease PF02265.11 ESA17962.1 - 9e-56 189.3 0.0 8.5e-54 182.8 0.0 2.0 1 1 0 1 1 1 1 S1/P1 Nuclease zf-H2C2_2 PF13465.1 ESA17963.1 - 1.7e-41 138.4 74.4 8.2e-08 32.1 2.0 10.1 10 1 0 10 10 10 7 Zinc-finger double domain zf-C2H2 PF00096.21 ESA17963.1 - 3e-33 112.1 81.8 1.7e-05 24.8 1.3 9.8 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA17963.1 - 1.2e-13 50.3 76.9 0.052 13.8 1.3 9.7 10 0 0 10 10 10 9 C2H2-type zinc finger GGDN PF05165.7 ESA17963.1 - 0.0084 15.1 0.0 14 4.5 0.0 3.5 3 1 0 3 3 3 2 GGDN family Helicase_C PF00271.26 ESA17965.1 - 2.3e-16 59.3 0.0 5.3e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA17965.1 - 4.3e-16 58.8 0.0 5.5e-13 48.7 0.0 2.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA17965.1 - 0.0016 18.2 0.0 0.064 13.0 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DNA_pol3_delta PF06144.8 ESA17967.1 - 0.0086 15.6 3.3 0.2 11.1 0.1 3.0 1 1 1 3 3 3 1 DNA polymerase III, delta subunit Prp19_bind PF06991.6 ESA17967.1 - 0.024 13.9 0.6 2.4 7.3 0.0 2.1 1 1 1 2 2 2 0 Splicing factor, Prp19-binding domain XFP PF03894.10 ESA17967.1 - 0.061 12.9 0.2 0.22 11.0 0.0 1.8 2 0 0 2 2 2 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase HMG_box PF00505.14 ESA17968.1 - 5.5e-07 29.7 1.8 9.1e-07 29.0 0.2 2.1 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA17968.1 - 7.7e-07 29.3 0.9 1.4e-06 28.5 0.2 1.7 2 0 0 2 2 2 1 HMG-box domain UTP15_C PF09384.5 ESA17969.1 - 1.1e-44 151.6 0.2 2.1e-44 150.8 0.2 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 ESA17969.1 - 1.3e-31 107.3 9.6 3e-07 30.0 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.3 ESA17969.1 - 4.1e-05 21.9 0.7 0.12 10.4 0.1 3.2 1 1 0 3 3 3 3 Nucleoporin Nup120/160 Nucleoside_tran PF01733.13 ESA17970.1 - 3.6e-41 141.3 10.5 3.6e-35 121.6 5.1 2.1 1 1 1 2 2 2 2 Nucleoside transporter DUF912 PF06024.7 ESA17970.1 - 2.3 8.3 5.7 2 8.5 2.4 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Ank_2 PF12796.2 ESA17971.1 - 3.8e-30 104.0 0.1 1.6e-11 44.3 0.1 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 ESA17971.1 - 4.6e-13 48.2 0.0 0.061 13.1 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 ESA17971.1 - 9.1e-10 38.7 0.4 0.0018 18.7 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA17971.1 - 3.1e-09 36.1 0.1 2.3 8.7 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 ESA17971.1 - 6.9e-05 22.9 0.0 0.37 11.1 0.0 3.7 2 1 3 5 5 5 3 Ankyrin repeats (many copies) F-box-like PF12937.2 ESA17971.1 - 0.004 16.8 0.0 0.0082 15.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like LTV PF04180.9 ESA17972.1 - 2.1e-52 179.0 36.0 1.5e-45 156.4 16.4 3.8 1 1 1 3 3 3 2 Low temperature viability protein D123 PF07065.9 ESA17973.1 - 9e-102 340.1 3.5 1.1e-101 339.9 2.4 1.1 1 0 0 1 1 1 1 D123 DUF4343 PF14243.1 ESA17973.1 - 0.0003 20.6 0.2 0.00056 19.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) Gtr1_RagA PF04670.7 ESA17973.1 - 0.12 11.5 0.3 0.23 10.5 0.2 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Histone PF00125.19 ESA17975.1 - 4.4e-23 81.1 0.0 6.2e-23 80.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T PF15511.1 ESA17975.1 - 0.18 11.0 0.2 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T p450 PF00067.17 ESA17976.1 - 1.7e-40 138.9 0.1 1.9e-40 138.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA17977.1 - 1.6e-30 106.0 0.5 1.8e-30 105.8 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA17978.1 - 3.3e-10 39.1 0.7 4.2e-10 38.7 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M16 PF00675.15 ESA17978.1 - 0.2 11.3 1.2 8.1 6.1 0.1 2.2 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) ABC2_membrane PF01061.19 ESA17979.1 - 7.7e-35 119.9 20.9 1.3e-34 119.2 14.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESA17979.1 - 4e-20 72.5 0.0 6.9e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA17979.1 - 5.3e-06 26.6 0.3 0.0028 17.6 0.0 2.9 2 1 1 3 3 3 2 AAA domain AAA_25 PF13481.1 ESA17979.1 - 0.0024 17.2 0.0 0.024 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 ESA17979.1 - 0.0044 16.2 0.0 0.0083 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA17979.1 - 0.015 14.7 0.0 0.039 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ESA17979.1 - 0.027 14.6 0.0 0.16 12.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA17979.1 - 0.051 13.4 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESA17979.1 - 0.083 13.3 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein ABC2_membrane_3 PF12698.2 ESA17979.1 - 6.5 5.6 22.2 15 4.4 15.4 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Anemone_cytotox PF06369.7 ESA17980.1 - 2.7e-16 59.4 0.0 3.3e-16 59.1 0.0 1.0 1 0 0 1 1 1 1 Sea anemone cytotoxic protein Aegerolysin PF06355.8 ESA17980.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Aegerolysin RTBV_P46 PF06216.6 ESA17981.1 - 0.0022 16.9 1.0 0.0023 16.8 0.7 1.2 1 0 0 1 1 1 1 Rice tungro bacilliform virus P46 protein DUF972 PF06156.8 ESA17981.1 - 0.013 15.7 1.0 0.025 14.9 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Myosin_tail_1 PF01576.14 ESA17981.1 - 0.029 12.0 4.9 0.037 11.7 3.4 1.0 1 0 0 1 1 1 0 Myosin tail CENP-H PF05837.7 ESA17981.1 - 0.05 13.7 5.2 0.095 12.8 3.6 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) GrpE PF01025.14 ESA17981.1 - 0.057 12.9 1.8 0.085 12.3 1.3 1.2 1 0 0 1 1 1 0 GrpE Cortex-I_coil PF09304.5 ESA17981.1 - 0.099 12.6 4.6 0.2 11.7 3.2 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil HALZ PF02183.13 ESA17981.1 - 0.12 12.0 2.8 0.22 11.2 1.3 1.8 1 1 0 1 1 1 0 Homeobox associated leucine zipper DUF4225 PF13988.1 ESA17981.1 - 0.14 11.6 1.1 0.5 9.8 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4225) DUF904 PF06005.7 ESA17981.1 - 0.45 10.8 7.1 0.44 10.8 3.9 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF904) DUF755 PF05501.6 ESA17981.1 - 0.8 9.7 10.4 0.11 12.5 4.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DivIC PF04977.10 ESA17981.1 - 0.87 9.1 5.5 0.57 9.7 2.1 2.0 1 1 1 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.3 ESA17981.1 - 1.2 9.0 11.6 1.8 8.4 3.7 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.6 ESA17981.1 - 1.2 9.0 5.4 0.4 10.6 0.2 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1640 PF07798.6 ESA17981.1 - 1.6 8.7 9.2 4.3 7.3 5.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) bZIP_1 PF00170.16 ESA17981.1 - 4.7 7.2 11.8 0.098 12.6 1.0 2.7 3 0 0 3 3 3 0 bZIP transcription factor bZIP_2 PF07716.10 ESA17981.1 - 7.6 6.4 9.0 0.14 12.0 0.5 2.2 2 0 0 2 2 2 0 Basic region leucine zipper DUF605 PF04652.11 ESA17982.1 - 0.71 9.1 16.8 0.83 8.9 11.6 1.1 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 ESA17982.1 - 0.96 7.6 30.0 1 7.5 20.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 KTSC PF13619.1 ESA17982.1 - 4.5 6.9 12.0 29 4.4 0.1 2.5 2 0 0 2 2 2 0 KTSC domain DUF1093 PF06486.6 ESA17983.1 - 0.14 12.5 1.8 0.2 12.0 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1093) zf-C3HC4_3 PF13920.1 ESA17984.1 - 0.016 14.8 1.3 0.022 14.4 0.9 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA17984.1 - 0.02 14.9 3.3 0.031 14.3 2.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA17984.1 - 0.032 14.0 1.3 0.053 13.3 0.9 1.4 1 0 0 1 1 1 0 Ring finger domain Zn_Tnp_IS91 PF14319.1 ESA17984.1 - 0.062 12.8 0.5 0.078 12.4 0.3 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-C3HC4 PF00097.20 ESA17984.1 - 0.2 11.3 2.4 0.44 10.2 1.6 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YhfH PF14149.1 ESA17984.1 - 1.9 8.3 7.3 2.8 7.7 5.0 1.3 1 0 0 1 1 1 0 YhfH-like protein Abhydrolase_3 PF07859.8 ESA17986.1 - 9.8e-16 57.9 0.1 4.2e-09 36.3 0.0 2.9 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA17986.1 - 0.0028 17.4 0.0 0.0039 16.9 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF2424 PF10340.4 ESA17986.1 - 0.079 11.5 0.0 0.67 8.5 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2424) Metallophos PF00149.23 ESA17989.1 - 5.1e-43 146.8 1.3 6.6e-43 146.4 0.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Homez PF11569.3 ESA17989.1 - 0.16 11.0 0.1 0.3 10.1 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez TPR_11 PF13414.1 ESA17990.1 - 3.9e-12 45.6 0.0 9.1e-12 44.4 0.0 1.6 1 0 0 1 1 1 1 TPR repeat SET PF00856.23 ESA17990.1 - 1.6e-06 28.5 0.5 4.1e-06 27.2 0.0 1.9 3 0 0 3 3 3 1 SET domain DUF3890 PF13029.1 ESA17990.1 - 0.025 14.5 0.8 0.056 13.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3890) Dynamin_N PF00350.18 ESA17992.1 - 0.00055 19.7 0.0 0.00069 19.4 0.0 1.2 1 0 0 1 1 1 1 Dynamin family F-box PF00646.28 ESA17993.1 - 0.00094 18.7 0.0 0.027 14.1 0.4 2.8 3 1 0 3 3 3 1 F-box domain F-box-like PF12937.2 ESA17993.1 - 0.0035 17.0 3.3 0.0053 16.4 0.7 2.3 2 0 0 2 2 2 1 F-box-like WYL PF13280.1 ESA17994.1 - 0.0022 17.8 2.0 0.005 16.7 1.2 1.8 2 1 0 2 2 2 1 WYL domain WHIM2 PF15613.1 ESA17994.1 - 0.03 14.2 0.3 0.074 13.0 0.2 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 TIMELESS PF04821.9 ESA17995.1 - 5.9e-31 107.7 10.4 1.9e-15 56.8 3.0 2.8 2 0 0 2 2 2 2 Timeless protein TIMELESS_C PF05029.8 ESA17995.1 - 2.6e-17 63.0 2.0 2.6e-17 63.0 1.4 3.4 4 0 0 4 4 4 2 Timeless protein C terminal region NOB1_Zn_bind PF08772.6 ESA17996.1 - 0.016 14.9 1.3 0.016 14.9 0.9 2.0 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-FPG_IleRS PF06827.9 ESA17996.1 - 0.06 12.9 2.5 0.16 11.6 1.7 1.7 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Mo25 PF08569.6 ESA17997.1 - 2.1e-137 457.7 12.5 2.3e-137 457.5 8.7 1.0 1 0 0 1 1 1 1 Mo25-like HEAT_2 PF13646.1 ESA17997.1 - 0.033 14.4 0.0 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 HEAT repeats DUF544 PF04424.8 ESA17997.1 - 0.15 11.8 3.3 1.3 8.8 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF544) GHMP_kinases_N PF00288.21 ESA17998.1 - 1e-21 76.7 0.6 2.9e-21 75.3 0.4 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESA17998.1 - 1.1e-07 31.9 0.0 3e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal APC8 PF04049.8 ESA17999.1 - 4.6e-40 136.6 0.3 1e-39 135.4 0.2 1.6 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 ESA17999.1 - 4.7e-19 67.1 15.7 0.00039 19.8 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA17999.1 - 7.9e-19 67.0 17.1 1e-05 25.1 0.0 6.1 6 1 1 7 7 7 4 TPR repeat TPR_2 PF07719.12 ESA17999.1 - 8e-17 59.7 16.8 0.054 13.4 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 ESA17999.1 - 3.7e-11 41.9 15.2 0.012 15.3 0.0 7.4 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA17999.1 - 3.6e-10 39.5 0.2 0.039 14.5 0.0 6.5 6 2 1 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA17999.1 - 5.5e-10 39.0 12.3 0.00017 21.4 0.0 5.9 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA17999.1 - 1.5e-08 35.0 4.4 0.23 12.2 0.0 5.9 7 1 1 8 8 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA17999.1 - 3.3e-07 29.9 3.0 0.0022 18.0 0.0 5.9 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA17999.1 - 0.00053 19.5 11.8 0.24 11.3 0.0 6.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA17999.1 - 0.0032 17.7 3.6 0.72 10.2 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.5 ESA17999.1 - 0.0044 15.8 1.2 2 7.0 0.1 3.2 2 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) Apc3 PF12895.2 ESA17999.1 - 0.058 13.5 16.8 1.1 9.3 0.1 4.9 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Rapsyn_N PF10579.4 ESA17999.1 - 0.12 12.2 0.2 0.72 9.6 0.0 2.4 2 1 1 3 3 3 0 Rapsyn N-terminal myristoylation and linker region TPR_6 PF13174.1 ESA17999.1 - 0.76 10.3 15.1 19 6.0 0.1 6.4 8 0 0 8 8 6 0 Tetratricopeptide repeat NTase_sub_bind PF08780.6 ESA18000.1 - 0.039 13.7 0.1 0.052 13.3 0.1 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like F-box-like PF12937.2 ESA18001.1 - 0.00072 19.2 0.9 0.0024 17.5 0.6 1.9 1 0 0 1 1 1 1 F-box-like Phage_rep_O PF04492.8 ESA18001.1 - 0.051 13.7 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 Bacteriophage replication protein O F-box-like PF12937.2 ESA18002.1 - 0.00046 19.8 0.4 0.0012 18.4 0.3 1.7 1 0 0 1 1 1 1 F-box-like Pkinase_Tyr PF07714.12 ESA18003.1 - 2.6e-25 88.9 0.0 3.4e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18003.1 - 5.6e-22 78.1 0.0 7.4e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18005.1 - 1.6e-26 92.9 0.0 1.9e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18005.1 - 6e-20 71.4 0.0 7.9e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Cu-binding_MopE PF11617.3 ESA18005.1 - 1.1 9.0 3.6 4.2 7.2 0.0 2.9 3 0 0 3 3 3 0 Protein metal binding site BTB PF00651.26 ESA18006.1 - 1.5e-17 63.5 0.2 4.7e-17 61.9 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA18006.1 - 1.3e-06 28.1 2.1 0.00027 20.7 0.1 3.4 2 1 2 4 4 4 2 BTB And C-terminal Kelch Vac_Fusion PF02346.11 ESA18007.1 - 0.99 8.8 13.9 2.2 7.7 1.8 3.7 3 0 0 3 3 3 0 Chordopoxvirus fusion protein AhpC-TSA PF00578.16 ESA18007.1 - 2.4 7.8 5.7 27 4.4 1.6 3.0 1 1 1 2 2 2 0 AhpC/TSA family GPS PF01825.16 ESA18008.1 - 0.012 15.7 1.7 0.37 10.9 0.1 2.7 2 0 0 2 2 2 0 Latrophilin/CL-1-like GPS domain TraT PF05818.7 ESA18008.1 - 0.027 13.8 0.7 0.98 8.8 0.1 2.4 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Glutaredoxin PF00462.19 ESA18008.1 - 0.12 12.3 0.1 1 9.4 0.0 2.4 2 1 0 2 2 2 0 Glutaredoxin Lipocalin_3 PF12702.2 ESA18008.1 - 0.51 10.4 4.8 3.5 7.7 0.2 2.9 3 0 0 3 3 3 0 Lipocalin-like Pkinase_Tyr PF07714.12 ESA18009.1 - 7.7e-25 87.4 1.1 2.9e-24 85.5 0.2 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18009.1 - 2.2e-19 69.6 6.7 2.2e-19 69.6 4.6 2.1 2 1 0 2 2 2 1 Protein kinase domain TraT PF05818.7 ESA18009.1 - 0.026 13.9 1.3 1.3 8.4 0.1 2.3 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Astacin PF01400.19 ESA18012.1 - 1.5e-08 34.2 2.0 1.8e-08 33.9 1.4 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Papilloma_E5A PF05776.7 ESA18014.1 - 0.097 12.8 4.6 0.13 12.4 3.2 1.2 1 1 0 1 1 1 0 Papillomavirus E5A protein DsbB PF02600.11 ESA18017.1 - 0.16 11.7 4.8 0.078 12.7 1.3 2.1 1 1 0 2 2 2 0 Disulfide bond formation protein DsbB PNP_UDP_1 PF01048.15 ESA18018.1 - 3.2e-24 85.2 0.0 4.9e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily DD_K PF12121.3 ESA18018.1 - 0.08 12.8 2.6 0.084 12.7 0.1 2.1 2 0 0 2 2 2 0 Dermaseptin zf-C2H2_4 PF13894.1 ESA18019.1 - 0.00017 21.6 2.2 0.00081 19.5 1.5 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA18019.1 - 0.00083 19.5 3.2 0.00083 19.5 2.2 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA18019.1 - 2.1 8.7 6.0 0.92 9.9 0.2 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESA18020.1 - 5.4e-12 45.3 16.1 4.5e-06 26.6 3.2 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA18020.1 - 6.9e-12 45.0 15.7 1.8e-09 37.3 2.2 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA18020.1 - 1e-09 38.0 14.4 6.5e-05 22.9 3.3 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA18020.1 - 0.0019 18.0 12.0 0.016 15.0 0.2 2.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA18020.1 - 0.015 15.4 10.0 0.26 11.4 1.7 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TP1 PF02079.11 ESA18020.1 - 0.017 14.8 6.9 0.049 13.3 4.2 2.2 1 1 0 1 1 1 0 Nuclear transition protein 1 Rad50_zn_hook PF04423.9 ESA18020.1 - 0.14 11.6 0.8 0.23 10.9 0.4 1.7 1 1 0 1 1 1 0 Rad50 zinc hook motif zf-met PF12874.2 ESA18020.1 - 0.36 11.1 5.1 0.41 10.9 1.0 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.1 ESA18020.1 - 0.75 9.5 6.4 8.8 6.1 0.1 2.6 2 1 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.2 ESA18020.1 - 0.8 9.8 7.0 0.83 9.8 2.5 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Astacin PF01400.19 ESA18021.1 - 7.8e-21 74.3 0.0 9.7e-21 74.0 0.0 1.0 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Phage_integrase PF00589.17 ESA18022.1 - 1.8e-07 30.9 0.0 2e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family Phage_integrase PF00589.17 ESA18023.1 - 6.5e-05 22.6 0.0 0.00062 19.4 0.0 2.0 1 1 0 1 1 1 1 Phage integrase family Pkinase PF00069.20 ESA18024.1 - 0.0017 17.5 0.1 1.3 8.1 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18025.1 - 6.7e-06 25.3 0.0 1.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18025.1 - 0.00014 21.0 1.3 0.00062 19.0 0.9 1.9 1 1 0 1 1 1 1 Protein kinase domain Tnp_zf-ribbon_2 PF13842.1 ESA18025.1 - 0.01 16.2 3.2 0.023 15.1 2.2 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon NinF PF05810.7 ESA18025.1 - 0.039 13.7 0.2 0.069 12.9 0.1 1.4 1 0 0 1 1 1 0 NinF protein HypA PF01155.14 ESA18025.1 - 0.076 12.7 0.2 0.12 12.0 0.2 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Pkinase_Tyr PF07714.12 ESA18027.1 - 1.7e-47 161.7 0.0 3.1e-47 160.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18027.1 - 3.3e-40 137.8 0.0 5.8e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA18027.1 - 0.00065 18.8 0.1 0.0012 17.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA18027.1 - 0.0047 16.6 0.0 0.0083 15.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Homeobox PF00046.24 ESA18029.1 - 2.1e-18 65.6 4.1 4.5e-18 64.6 2.8 1.6 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 ESA18029.1 - 0.014 15.0 1.6 0.029 14.0 0.0 2.4 2 0 0 2 2 2 0 Homeobox KN domain WW PF00397.21 ESA18030.1 - 5.9e-05 22.8 5.1 0.00015 21.5 3.6 3.3 3 0 0 3 3 3 2 WW domain tRNA-synt_His PF13393.1 ESA18031.1 - 3.8e-38 131.2 0.0 5.2e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 ESA18031.1 - 1.1e-24 86.8 0.0 1.8e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA18031.1 - 5.1e-07 29.5 0.1 1.4e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.15 ESA18031.1 - 5.1e-05 22.5 0.1 0.058 12.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 ESA18031.1 - 0.029 13.1 0.1 3.5 6.3 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Nsp1_C PF05064.8 ESA18032.1 - 0.011 15.3 1.6 0.011 15.3 1.1 2.9 2 0 0 2 2 2 0 Nsp1-like C-terminal region Atg14 PF10186.4 ESA18032.1 - 0.018 14.0 0.7 0.018 14.0 0.5 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Geminin PF07412.7 ESA18032.1 - 0.02 14.5 3.5 0.02 14.5 2.4 2.1 1 1 1 2 2 2 0 Geminin DUF1192 PF06698.6 ESA18032.1 - 0.034 13.9 0.8 0.092 12.5 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) PEP-utilisers_N PF05524.8 ESA18032.1 - 0.092 12.5 0.3 0.092 12.5 0.2 1.9 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal DUF641 PF04859.7 ESA18032.1 - 0.94 9.2 9.1 0.083 12.6 0.6 3.0 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) SlyX PF04102.7 ESA18032.1 - 1.1 9.7 16.6 0.083 13.2 1.6 3.2 2 1 0 2 2 2 0 SlyX DUF2730 PF10805.3 ESA18032.1 - 1.1 8.9 7.9 0.65 9.7 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) LRR_4 PF12799.2 ESA18032.1 - 1.6 8.4 7.5 5.2 6.7 0.8 4.0 2 2 0 2 2 2 0 Leucine Rich repeats (2 copies) Occludin_ELL PF07303.8 ESA18032.1 - 2.4 8.9 13.8 0.059 14.1 1.7 2.7 1 1 0 2 2 2 0 Occludin homology domain DNA_ligase_A_M PF01068.16 ESA18033.1 - 2.2e-49 167.5 0.2 8.1e-49 165.7 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 ESA18033.1 - 4.1e-38 130.9 0.1 3.2e-37 128.0 0.0 2.3 3 0 0 3 3 3 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 ESA18033.1 - 2.7e-15 56.5 0.0 6.6e-15 55.2 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.21 ESA18033.1 - 6e-12 45.5 0.5 2.5e-09 37.1 0.0 3.0 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain mRNA_cap_enzyme PF01331.14 ESA18033.1 - 8.9e-06 25.5 0.1 0.00013 21.7 0.1 2.8 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain PTCB-BRCT PF12738.2 ESA18033.1 - 0.00011 21.9 0.0 0.048 13.5 0.0 2.7 2 0 0 2 2 2 2 twin BRCT domain DNA_ligase_IV PF11411.3 ESA18033.1 - 0.00038 20.1 0.1 0.00095 18.8 0.1 1.7 1 0 0 1 1 1 1 DNA ligase IV MbeD_MobD PF04899.7 ESA18033.1 - 0.069 13.0 0.5 24 4.9 0.0 3.1 3 0 0 3 3 3 0 MbeD/MobD like Glycos_transf_2 PF00535.21 ESA18034.1 - 2.8e-26 92.1 0.2 4e-26 91.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 ESA18034.1 - 5.9e-07 29.5 0.0 9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 ESA18034.1 - 0.00021 20.4 0.2 0.00032 19.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF3925 PF13063.1 ESA18034.1 - 0.041 13.9 0.2 0.041 13.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3925) Glyco_tranf_2_4 PF13704.1 ESA18034.1 - 0.041 14.1 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Shisa PF13908.1 ESA18034.1 - 0.097 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Phosphoesterase PF04185.9 ESA18035.1 - 2.3e-21 76.4 1.5 1.6e-20 73.6 1.0 1.9 1 1 0 1 1 1 1 Phosphoesterase family eIF2A PF08662.6 ESA18036.1 - 2.4e-85 285.1 0.4 1.6e-80 269.3 0.0 2.6 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 ESA18036.1 - 0.00021 19.6 0.0 0.34 9.1 0.0 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain FlaG PF03646.10 ESA18036.1 - 0.099 12.7 0.2 0.099 12.7 0.2 3.3 2 1 0 2 2 2 0 FlaG protein SKIP_SNW PF02731.10 ESA18037.1 - 5.9e-67 224.0 2.1 5.9e-67 224.0 1.5 2.6 3 0 0 3 3 3 1 SKIP/SNW domain RRXRR PF14239.1 ESA18037.1 - 1.2 8.4 7.7 2.6 7.4 5.4 1.5 1 0 0 1 1 1 0 RRXRR protein UBN2 PF14223.1 ESA18038.1 - 0.00023 20.9 0.3 0.23 11.2 0.0 2.4 2 0 0 2 2 2 2 gag-polypeptide of LTR copia-type zinc_ribbon_2 PF13240.1 ESA18038.1 - 0.012 15.0 5.9 0.031 13.7 4.1 1.8 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.2 ESA18038.1 - 0.027 14.3 4.3 0.053 13.3 3.0 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF4413 PF14372.1 ESA18038.1 - 0.13 12.2 4.6 2 8.4 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) zf-DBF PF07535.7 ESA18038.1 - 0.51 10.0 11.0 5.8 6.6 5.8 3.0 2 1 0 2 2 2 0 DBF zinc finger HypA PF01155.14 ESA18038.1 - 2.4 7.8 6.2 4.9 6.8 4.3 1.6 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family AKAP28 PF14469.1 ESA18038.1 - 2.7 7.6 7.1 6.8 6.3 0.1 3.1 2 1 1 3 3 3 0 28 kDa A-kinase anchor Mvb12 PF09452.5 ESA18039.1 - 0.042 14.0 0.8 12 6.1 0.0 2.6 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 JmjN PF02375.12 ESA18039.1 - 0.15 11.5 0.5 0.44 10.1 0.1 2.0 2 0 0 2 2 2 0 jmjN domain HMG_box PF00505.14 ESA18040.1 - 1.5e-10 41.1 0.6 2.6e-10 40.4 0.4 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box MAT_Alpha1 PF04769.7 ESA18040.1 - 3.5e-05 23.2 0.9 6.4e-05 22.3 0.6 1.4 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG_box_2 PF09011.5 ESA18040.1 - 0.00065 20.0 0.6 0.0012 19.1 0.4 1.5 1 0 0 1 1 1 1 HMG-box domain Ribosomal_L13 PF00572.13 ESA18040.1 - 0.12 12.4 3.9 32 4.5 0.0 3.6 2 1 3 5 5 5 0 Ribosomal protein L13 RRP7 PF12923.2 ESA18040.1 - 0.39 10.7 6.1 3.3 7.7 0.1 3.5 2 1 3 5 5 5 0 Ribosomal RNA-processing protein 7 (RRP7) CHCH PF06747.8 ESA18040.1 - 1.4 8.8 6.2 66 3.5 0.1 3.4 3 0 0 3 3 3 0 CHCH domain PPR_2 PF13041.1 ESA18040.1 - 2.7 8.0 8.3 45 4.1 0.1 4.1 4 0 0 4 4 4 0 PPR repeat family RVP_2 PF08284.6 ESA18044.1 - 2.4e-10 40.4 0.0 3.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA18044.1 - 6.2e-06 25.7 0.0 9.3e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESA18044.1 - 3e-05 24.4 0.0 5.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA18044.1 - 0.00011 21.9 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2B PF12384.3 ESA18044.1 - 0.0021 17.4 0.0 0.0034 16.7 0.0 1.3 1 0 0 1 1 1 1 Ty3 transposon peptidase Spuma_A9PTase PF03539.9 ESA18044.1 - 0.014 15.2 0.0 0.044 13.6 0.0 1.9 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) V_ATPase_I PF01496.14 ESA18044.1 - 1.7 6.3 6.7 2.4 5.8 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ycf1 PF05758.7 ESA18044.1 - 5.4 4.5 9.7 7.8 4.0 6.7 1.2 1 0 0 1 1 1 0 Ycf1 Fer4_7 PF12838.2 ESA18046.1 - 0.00034 20.9 0.0 4.2 7.8 0.0 4.0 2 2 2 4 4 4 1 4Fe-4S dicluster domain AP_endonuc_2 PF01261.19 ESA18046.1 - 0.0029 16.9 0.0 5.4 6.2 0.0 3.5 4 0 0 4 4 4 2 Xylose isomerase-like TIM barrel THF_DHG_CYH PF00763.18 ESA18046.1 - 0.0044 17.0 1.3 1.8 8.5 0.0 3.5 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF4134 PF13572.1 ESA18046.1 - 0.022 14.8 5.8 59 3.8 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4134) BBS2_Mid PF14783.1 ESA18046.1 - 0.026 14.3 15.9 1 9.1 0.8 3.4 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Swi5 PF07061.6 ESA18046.1 - 2.3 8.0 16.3 7.6 6.3 0.3 4.6 4 0 0 4 4 4 0 Swi5 Cation_ATPase_C PF00689.16 ESA18050.1 - 2.2e-18 66.4 2.9 2.8e-18 66.0 2.0 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus zf-BED PF02892.10 ESA18054.1 - 6.6e-10 38.5 0.5 6.6e-10 38.5 0.3 1.6 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA18054.1 - 6.6e-05 22.9 0.2 0.00017 21.6 0.2 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA18054.1 - 0.0081 16.4 1.2 2.7 8.4 0.0 2.3 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_jaz PF12171.3 ESA18054.1 - 0.055 13.6 0.5 0.11 12.6 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.7 ESA18054.1 - 0.096 12.2 0.5 0.18 11.3 0.3 1.5 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2 PF00096.21 ESA18054.1 - 1 9.8 3.6 7.1 7.1 2.5 2.3 1 1 0 1 1 1 0 Zinc finger, C2H2 type DUF331 PF03889.8 ESA18055.1 - 0.15 11.3 0.6 0.22 10.8 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function Transposase_21 PF02992.9 ESA18056.1 - 3.3e-08 32.9 0.1 7.6e-08 31.7 0.1 1.6 1 0 0 1 1 1 1 Transposase family tnp2 DUF4218 PF13960.1 ESA18057.1 - 0.00049 19.5 0.1 0.00058 19.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) NmrA PF05368.8 ESA18059.1 - 2.6e-41 141.3 0.0 3.2e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA18059.1 - 1.4e-11 44.7 0.0 1.7e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA18059.1 - 1.2e-05 24.1 0.0 2e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 ESA18059.1 - 7e-05 22.8 0.1 0.00011 22.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA18059.1 - 9.9e-05 22.0 0.1 0.00015 21.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESA18059.1 - 0.0016 17.9 0.0 0.0036 16.7 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 ESA18059.1 - 0.054 13.4 0.0 0.16 11.8 0.0 1.7 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.8 ESA18060.1 - 4.2e-50 170.1 0.0 4.7e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA18060.1 - 1.3e-09 38.2 0.0 1.8e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA18060.1 - 3.4e-05 22.7 0.0 4.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ESA18060.1 - 0.00013 21.7 0.2 0.00022 20.9 0.2 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 ESA18060.1 - 0.00058 19.8 0.3 0.001 19.0 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 ESA18060.1 - 0.0021 17.5 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 ESA18060.1 - 0.011 15.5 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus mIF3 PF14877.1 ESA18060.1 - 0.095 12.0 0.0 0.29 10.4 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial translation initiation factor TrkA_N PF02254.13 ESA18060.1 - 0.11 12.4 0.1 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain NmrA PF05368.8 ESA18061.1 - 5.5e-51 173.0 0.1 6.6e-51 172.8 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA18061.1 - 2.1e-13 50.6 0.0 3.2e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA18061.1 - 2e-05 23.4 0.0 4.1e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ESA18061.1 - 0.00014 21.5 0.2 0.00024 20.8 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 ESA18061.1 - 0.00062 19.7 0.3 0.0012 18.7 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 ESA18061.1 - 0.0025 17.2 0.1 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.15 ESA18061.1 - 0.015 15.1 0.1 0.035 14.0 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.12 ESA18061.1 - 0.046 14.1 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 ESA18061.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NmrA PF05368.8 ESA18062.1 - 1.5e-40 138.8 0.1 1.7e-22 79.8 0.0 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.1 ESA18062.1 - 1.2e-11 44.9 0.1 2.9e-11 43.6 0.1 1.6 1 1 1 2 2 2 1 NADH(P)-binding adh_short PF00106.20 ESA18062.1 - 0.00023 21.0 0.2 0.00043 20.2 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA18062.1 - 0.00043 19.9 0.1 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 KR domain DapB_N PF01113.15 ESA18062.1 - 0.027 14.4 0.0 0.069 13.0 0.0 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.15 ESA18062.1 - 0.03 14.4 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 ESA18062.1 - 0.045 13.1 0.0 0.079 12.3 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 ESA18062.1 - 0.066 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.12 ESA18062.1 - 0.076 13.4 0.1 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Toxin_54 PF15533.1 ESA18062.1 - 0.081 13.1 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 Putative toxin 54 BTB PF00651.26 ESA18064.1 - 6.8e-08 32.4 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Transposase_21 PF02992.9 ESA18065.1 - 2.4e-10 39.8 0.3 2.4e-10 39.8 0.2 1.5 2 0 0 2 2 2 1 Transposase family tnp2 DUF2591 PF10765.4 ESA18066.1 - 0.016 15.4 1.3 0.05 13.8 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) PUD PF03714.9 ESA18066.1 - 0.11 12.6 0.3 0.11 12.6 0.2 3.1 3 0 0 3 3 3 0 Bacterial pullanase-associated domain zf-Tim10_DDP PF02953.10 ESA18066.1 - 0.48 9.7 3.6 0.24 10.7 0.5 2.0 2 0 0 2 2 2 0 Tim10/DDP family zinc finger Phlebovirus_NSM PF07246.6 ESA18068.1 - 9.6e-05 21.6 4.0 0.00015 20.9 2.8 1.4 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M VASP_tetra PF08776.6 ESA18068.1 - 0.084 12.1 0.4 0.26 10.6 0.3 1.8 1 0 0 1 1 1 0 VASP tetramerisation domain Tom37_C PF11801.3 ESA18068.1 - 0.19 11.5 5.0 0.37 10.6 3.5 1.4 1 0 0 1 1 1 0 Tom37 C-terminal domain Dynein_light PF01221.13 ESA18068.1 - 0.22 11.5 1.1 28 4.8 0.1 2.7 3 0 0 3 3 3 0 Dynein light chain type 1 eRF1_3 PF03465.10 ESA18068.1 - 0.85 9.9 4.5 34 4.7 3.1 2.6 1 1 0 1 1 1 0 eRF1 domain 3 Pkinase_Tyr PF07714.12 ESA18070.1 - 7e-37 126.9 0.0 7.9e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18070.1 - 2e-35 122.2 0.0 2.4e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18070.1 - 7.4e-05 22.5 0.3 0.00076 19.2 0.3 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA18070.1 - 0.0011 18.2 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA18070.1 - 0.052 12.7 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA18070.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Spt5-NGN PF03439.8 ESA18071.1 - 0.00026 20.6 5.3 1.9 8.3 0.0 5.1 5 0 0 5 5 5 2 Early transcription elongation factor of RNA pol II, NGN section DUF179 PF02622.10 ESA18071.1 - 0.0099 15.5 3.9 4.8 6.7 0.1 3.6 3 0 0 3 3 3 2 Uncharacterized ACR, COG1678 DUF4368 PF14287.1 ESA18071.1 - 0.011 15.5 4.2 3.3 7.5 0.0 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4368) ACT_7 PF13840.1 ESA18071.1 - 0.013 15.0 0.3 17 4.9 0.0 4.1 4 0 0 4 4 4 0 ACT domain DUF4413 PF14372.1 ESA18071.1 - 0.31 11.0 16.7 7.3 6.6 0.0 5.7 5 1 0 5 5 5 0 Domain of unknown function (DUF4413) Orn_DAP_Arg_deC PF00278.17 ESA18071.1 - 0.91 9.2 3.4 19 5.0 0.0 3.8 3 1 0 3 3 3 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Pkinase PF00069.20 ESA18072.1 - 1.2e-33 116.3 0.1 1.3e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18072.1 - 1.4e-30 106.2 0.0 1.6e-30 106.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA18072.1 - 0.034 13.3 0.1 0.056 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF2805 PF10985.3 ESA18073.1 - 0.041 13.8 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) Fer4 PF00037.22 ESA18073.1 - 0.14 11.8 0.9 0.26 10.9 0.7 1.5 1 0 0 1 1 1 0 4Fe-4S binding domain VWA_2 PF13519.1 ESA18074.1 - 3.6e-15 56.4 0.0 5.4e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA18074.1 - 4.9e-06 26.3 0.0 9.9e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 ESA18074.1 - 0.00019 21.3 0.1 0.0078 16.0 0.0 2.3 2 0 0 2 2 2 1 vWA found in TerF C terminus BTB PF00651.26 ESA18076.1 - 8.8e-14 51.4 0.1 1.8e-13 50.4 0.0 1.6 1 1 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA18076.1 - 2.5e-11 43.7 0.1 1.7e-10 41.0 0.0 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA18076.1 - 6.3e-06 25.9 0.7 0.00023 20.9 0.2 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch SNF2_N PF00176.18 ESA18078.1 - 3.2e-82 275.6 1.2 3.2e-82 275.6 0.8 2.4 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 ESA18078.1 - 7.7e-24 83.4 2.5 9.2e-24 83.1 0.3 2.2 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.26 ESA18078.1 - 1.1e-16 60.3 0.0 1.1e-16 60.3 0.0 3.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain SnAC PF14619.1 ESA18078.1 - 1.6e-14 53.7 3.3 1.6e-14 53.7 2.3 4.1 3 1 1 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex HSA PF07529.8 ESA18078.1 - 6.2e-11 41.9 15.3 6.2e-11 41.9 10.6 4.1 5 0 0 5 5 5 1 HSA QLQ PF08880.6 ESA18078.1 - 1.3e-08 34.1 3.5 4e-08 32.5 2.4 2.0 1 0 0 1 1 1 1 QLQ AT_hook PF02178.14 ESA18078.1 - 0.044 13.4 3.2 0.17 11.6 2.2 2.1 1 0 0 1 1 1 0 AT hook motif T-box PF00907.17 ESA18079.1 - 2.6 7.5 5.8 3 7.2 0.1 2.7 2 1 0 2 2 2 0 T-box HIG_1_N PF04588.8 ESA18080.1 - 1.7e-18 66.1 1.4 2.1e-18 65.7 1.0 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region ETRAMP PF09716.5 ESA18080.1 - 0.024 14.5 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2909 PF11137.3 ESA18080.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Pkinase PF00069.20 ESA18081.1 - 6.6e-35 120.5 0.6 3.1e-34 118.3 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18081.1 - 4.7e-33 114.3 0.0 7.4e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18081.1 - 0.00031 20.5 0.1 0.00043 20.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DDE_1 PF03184.14 ESA18086.1 - 9.2e-09 34.7 2.3 1e-06 28.0 0.1 2.7 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF360 PF04020.8 ESA18087.1 - 2.8 8.3 9.9 4.9 7.5 6.9 1.4 1 1 0 1 1 1 0 Membrane protein of unknown function p450 PF00067.17 ESA18088.1 - 2e-43 148.6 0.2 2.4e-43 148.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MIR PF02815.14 ESA18089.1 - 5.9e-05 22.6 1.2 0.00069 19.2 0.5 2.5 2 1 0 2 2 2 1 MIR domain Pkinase_Tyr PF07714.12 ESA18090.1 - 9.1e-42 142.9 0.2 2.8e-38 131.4 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18090.1 - 1.3e-35 122.8 0.7 1.8e-32 112.5 0.1 2.0 1 1 1 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ESA18090.1 - 8.5e-05 21.9 0.2 0.00012 21.4 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA18090.1 - 0.016 14.9 0.1 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA18090.1 - 0.099 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA18091.1 - 1.1e-07 31.2 0.0 1.2e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18091.1 - 3.5e-05 23.0 0.0 4.2e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TcdB_toxin_midN PF12256.3 ESA18091.1 - 0.054 12.9 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/N-terminal region Voldacs PF03517.8 ESA18093.1 - 5e-33 113.8 0.3 6.6e-33 113.4 0.2 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling GRAM PF02893.15 ESA18093.1 - 0.082 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 GRAM domain WD40 PF00400.27 ESA18094.1 - 3.7e-93 302.3 26.1 1.4e-13 50.0 0.3 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat NLE PF08154.7 ESA18094.1 - 6.6e-15 54.8 0.2 1.4e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.6 ESA18094.1 - 1.2e-09 38.1 0.1 0.015 15.0 0.0 3.9 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ESA18094.1 - 1.9e-08 32.9 4.8 0.0022 16.2 0.1 4.6 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA18094.1 - 3e-08 32.8 2.3 0.015 14.0 0.0 3.5 2 1 2 4 4 4 2 Nup133 N terminal like Nbas_N PF15492.1 ESA18094.1 - 3.3e-08 32.9 1.8 0.0062 15.6 0.0 4.5 2 2 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.7 ESA18094.1 - 0.0016 16.3 0.4 0.82 7.4 0.0 2.4 2 1 0 2 2 2 2 IKI3 family Cytochrom_D1 PF02239.11 ESA18094.1 - 0.0039 15.5 0.1 0.24 9.6 0.0 3.0 3 1 1 4 4 4 1 Cytochrome D1 heme domain Proteasome_A_N PF10584.4 ESA18094.1 - 0.029 13.6 4.3 0.77 9.1 0.1 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PD40 PF07676.7 ESA18094.1 - 0.034 13.8 2.9 6.8 6.4 0.0 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.9 ESA18094.1 - 0.18 10.5 0.0 3.1 6.4 0.0 2.6 2 1 1 3 3 3 0 Coatomer WD associated region Carb_kinase PF01256.12 ESA18095.1 - 4.2e-46 157.2 0.0 5.3e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 ESA18095.1 - 0.00069 18.8 0.0 0.0012 18.1 0.0 1.3 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.7 ESA18095.1 - 0.001 18.3 0.0 0.0037 16.4 0.0 1.7 1 1 0 2 2 2 1 Phosphomethylpyrimidine kinase SAM_decarbox PF01536.11 ESA18096.1 - 5e-102 340.9 0.0 6.3e-102 340.6 0.0 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase MULE PF10551.4 ESA18097.1 - 0.004 17.2 0.3 0.0059 16.7 0.2 1.3 1 0 0 1 1 1 1 MULE transposase domain DUF830 PF05708.7 ESA18097.1 - 0.06 13.3 1.0 2.6 7.9 0.0 2.0 1 1 1 2 2 2 0 Orthopoxvirus protein of unknown function (DUF830) RAI16-like PF10257.4 ESA18097.1 - 0.066 12.1 0.1 0.066 12.1 0.1 1.0 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein Pkinase_Tyr PF07714.12 ESA18098.1 - 1.2e-11 44.2 0.0 7.2e-11 41.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase C6_DPF PF10170.4 ESA18098.1 - 0.00014 21.8 1.6 0.18 11.8 0.1 2.4 2 0 0 2 2 2 2 Cysteine-rich domain DUF2789 PF10982.3 ESA18098.1 - 0.13 12.2 1.7 3.8 7.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) zf-AN1 PF01428.11 ESA18098.1 - 4 7.3 8.7 0.78 9.6 0.7 2.2 2 0 0 2 2 2 0 AN1-like Zinc finger A2L_zn_ribbon PF08792.5 ESA18099.1 - 0.0057 16.0 0.2 0.01 15.2 0.1 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain Glyco_hydro_108 PF05838.7 ESA18099.1 - 0.17 12.0 0.6 0.25 11.4 0.2 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase 108 mRNA_cap_enzyme PF01331.14 ESA18102.1 - 5.1e-06 26.3 0.0 9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Snurportin1 PF11538.3 ESA18102.1 - 0.00015 21.4 6.7 0.00038 20.1 4.7 1.7 1 0 0 1 1 1 1 Snurportin1 HDNR PF15115.1 ESA18103.1 - 0.52 10.2 5.2 0.81 9.5 3.6 1.6 1 1 0 1 1 1 0 Domain of unknown function with conserved HDNR motif TPR_11 PF13414.1 ESA18105.1 - 1.4e-17 63.0 5.1 9.7e-16 57.1 0.7 2.2 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA18105.1 - 5.4e-12 44.7 11.8 1.7e-05 24.1 0.2 4.2 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA18105.1 - 4.5e-09 35.5 6.6 0.0088 15.8 0.1 3.6 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18105.1 - 3.5e-05 23.6 2.7 0.066 13.1 0.2 3.2 1 1 3 4 4 4 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA18105.1 - 0.0002 21.4 5.7 0.00031 20.8 3.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA18105.1 - 0.00022 21.4 1.8 0.019 15.2 0.5 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA18105.1 - 0.0008 19.0 0.2 0.19 11.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 ESA18105.1 - 0.0048 16.5 5.9 2.1 8.3 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18105.1 - 0.0052 17.4 0.0 0.18 12.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18105.1 - 0.009 16.1 1.7 0.033 14.3 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA18105.1 - 0.0098 16.4 0.0 24 5.9 0.0 3.2 1 1 2 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.12 ESA18105.1 - 0.013 15.8 0.1 0.024 14.9 0.0 1.5 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Ion_trans PF00520.26 ESA18107.1 - 5.2e-06 25.8 18.9 8.7e-05 21.8 13.1 2.1 1 1 0 1 1 1 1 Ion transport protein MFS_1 PF07690.11 ESA18107.1 - 0.023 13.4 4.1 0.068 11.8 2.9 1.7 1 1 0 1 1 1 0 Major Facilitator Superfamily CBFB_NFYA PF02045.10 ESA18110.1 - 6.8e-11 42.5 6.8 1.2e-10 41.7 4.7 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B HypA PF01155.14 ESA18111.1 - 0.24 11.1 35.3 0.81 9.3 0.1 6.7 7 0 0 7 7 7 0 Hydrogenase expression/synthesis hypA family NOB1_Zn_bind PF08772.6 ESA18111.1 - 0.93 9.3 48.3 0.96 9.3 0.6 7.5 7 0 0 7 7 7 0 Nin one binding (NOB1) Zn-ribbon like SpoU_methylas_C PF12105.3 ESA18111.1 - 1 8.9 9.9 37 3.9 0.0 6.0 8 0 0 8 8 8 0 SpoU, rRNA methylase, C-terminal Retinin_C PF04527.7 ESA18112.1 - 0.068 13.1 0.3 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Drosophila Retinin like protein FRQ PF09421.5 ESA18113.1 - 1.7e-43 148.6 25.9 2.5e-22 78.5 4.1 3.9 1 1 3 4 4 4 4 Frequency clock protein La PF05383.12 ESA18113.1 - 0.001 18.7 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 La domain DUF1007 PF06226.8 ESA18114.1 - 0.05 13.3 0.1 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) WD40 PF00400.27 ESA18115.1 - 2.2e-42 141.4 15.7 4.4e-11 42.2 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA18115.1 - 1.6e-07 31.2 0.3 0.035 13.8 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.1 ESA18115.1 - 0.039 13.3 0.2 0.075 12.4 0.2 1.5 1 0 0 1 1 1 0 PQQ-like domain BTB PF00651.26 ESA18116.1 - 2.6e-19 69.2 0.1 4.9e-19 68.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA18116.1 - 7.6e-11 42.1 3.3 3.2e-10 40.1 2.3 2.1 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA18116.1 - 0.00054 19.7 1.9 0.0011 18.7 0.3 2.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch Pkinase PF00069.20 ESA18118.1 - 2.1e-39 135.2 0.0 5e-39 134.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18118.1 - 6.5e-39 133.5 0.0 9e-39 133.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_14 PF13173.1 ESA18121.1 - 3.6e-06 26.9 1.5 3.6e-06 26.9 1.1 2.0 2 1 0 3 3 2 1 AAA domain Zeta_toxin PF06414.7 ESA18121.1 - 3e-05 23.2 0.2 0.00055 19.0 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 ESA18121.1 - 0.00019 22.2 0.5 0.00019 22.2 0.3 2.0 2 1 0 2 2 1 1 AAA domain Thymidylate_kin PF02223.12 ESA18121.1 - 0.00024 20.5 3.9 0.0045 16.3 2.7 2.7 1 1 0 1 1 1 1 Thymidylate kinase ArgK PF03308.11 ESA18121.1 - 0.00037 19.3 1.1 0.0017 17.2 0.0 2.1 2 0 0 2 2 2 1 ArgK protein KTI12 PF08433.5 ESA18121.1 - 0.00042 19.6 0.1 0.00088 18.5 0.1 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.1 ESA18121.1 - 0.00043 20.3 0.0 0.00061 19.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain cobW PF02492.14 ESA18121.1 - 0.00076 18.9 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 ESA18121.1 - 0.00089 19.5 0.3 0.00089 19.5 0.2 3.2 1 1 1 3 3 3 1 AAA domain Arch_ATPase PF01637.13 ESA18121.1 - 0.0011 18.7 13.3 0.02 14.6 9.2 2.2 1 1 0 1 1 1 1 Archaeal ATPase DUF258 PF03193.11 ESA18121.1 - 0.0017 17.5 0.0 0.003 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 ESA18121.1 - 0.0035 17.4 0.0 0.027 14.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 ESA18121.1 - 0.0067 16.3 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 ESA18121.1 - 0.007 15.2 0.1 0.007 15.2 0.1 1.8 3 0 0 3 3 3 1 NB-ARC domain NACHT PF05729.7 ESA18121.1 - 0.0079 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain DUF815 PF05673.8 ESA18121.1 - 0.0088 14.9 0.3 0.73 8.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NTPase_1 PF03266.10 ESA18121.1 - 0.0096 15.6 2.4 0.014 15.0 0.1 2.5 2 2 3 5 5 4 1 NTPase ABC_tran PF00005.22 ESA18121.1 - 0.017 15.3 0.2 0.034 14.4 0.1 1.7 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.17 ESA18121.1 - 0.031 14.4 0.4 0.38 10.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase TrwB_AAD_bind PF10412.4 ESA18121.1 - 0.031 12.8 0.1 0.063 11.8 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain T2SE PF00437.15 ESA18121.1 - 0.055 12.3 0.2 0.14 11.0 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein MobB PF03205.9 ESA18121.1 - 0.056 13.1 1.9 0.069 12.8 0.1 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 ESA18121.1 - 0.068 12.6 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DAP3 PF10236.4 ESA18121.1 - 0.078 11.8 2.2 0.13 11.2 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_19 PF13245.1 ESA18121.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 ESA18121.1 - 0.11 12.7 0.1 0.54 10.4 0.0 2.1 2 1 1 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 ESA18121.1 - 0.14 12.0 0.0 0.64 9.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.12 ESA18121.1 - 0.56 9.9 0.1 0.56 9.9 0.1 3.0 2 2 1 3 3 3 0 Domain of unknown function DUF87 Thioredoxin_2 PF13098.1 ESA18121.1 - 1.9 8.7 7.3 2.8 8.1 0.0 3.4 2 2 0 2 2 2 0 Thioredoxin-like domain MerB PF03243.10 ESA18122.1 - 0.00011 22.0 0.4 0.53 10.1 0.0 2.3 2 0 0 2 2 2 2 Alkylmercury lyase Pkinase_Tyr PF07714.12 ESA18123.1 - 3.5e-06 26.2 0.0 4.6e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18123.1 - 0.00079 18.6 0.0 0.0016 17.6 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Arch_fla_DE PF04659.8 ESA18125.1 - 0.044 13.5 0.1 0.095 12.5 0.0 1.5 2 0 0 2 2 2 0 Archaeal flagella protein DUF1428 PF07237.6 ESA18126.1 - 0.15 12.0 0.2 0.36 10.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1428) PfkB PF00294.19 ESA18127.1 - 4.6e-49 167.1 0.0 5.6e-49 166.8 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase SHOCT PF09851.4 ESA18128.1 - 0.0048 16.3 1.5 0.0089 15.4 0.9 1.6 1 1 0 1 1 1 1 Short C-terminal domain DMAP_binding PF06464.6 ESA18128.1 - 0.082 13.5 0.2 0.096 13.2 0.1 1.1 1 0 0 1 1 1 0 DMAP1-binding Domain YMF19 PF02326.10 ESA18129.1 - 0.056 14.0 0.4 0.12 12.9 0.1 1.5 1 1 1 2 2 2 0 Plant ATP synthase F0 FAD_binding_4 PF01565.18 ESA18130.1 - 5.9e-29 100.3 2.9 9.1e-29 99.7 2.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 ESA18130.1 - 1.8e-06 27.7 3.0 1.8e-06 27.7 2.1 2.7 3 1 0 3 3 3 1 Berberine and berberine like SH2 PF00017.19 ESA18131.1 - 0.08 12.7 0.0 0.098 12.4 0.0 1.2 1 0 0 1 1 1 0 SH2 domain DUF3384 PF11864.3 ESA18136.1 - 4.9e-79 265.9 19.8 1.1e-78 264.8 12.5 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.10 ESA18136.1 - 2.8e-57 193.1 1.7 5.2e-57 192.2 1.2 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 ESA18136.1 - 6.5e-38 130.7 8.8 2.3e-34 119.0 1.8 3.5 3 0 0 3 3 3 3 Tuberin DUF1244 PF06844.6 ESA18136.1 - 0.0055 16.4 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1244) adh_short_C2 PF13561.1 ESA18140.1 - 0.8 9.4 4.5 0.52 10.0 0.5 2.4 3 0 0 3 3 3 0 Enoyl-(Acyl carrier protein) reductase TPR_11 PF13414.1 ESA18140.1 - 2.1 8.0 7.1 12 5.6 1.1 3.4 2 1 1 3 3 3 0 TPR repeat UvrD_C PF13361.1 ESA18141.1 - 8.9e-06 25.3 1.0 0.032 13.7 0.1 2.1 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ESA18141.1 - 0.0043 16.3 1.5 0.0061 15.8 0.2 1.7 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 ESA18141.1 - 0.042 13.9 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ADH_zinc_N PF00107.21 ESA18141.1 - 0.07 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase SNARE PF05739.14 ESA18143.1 - 4.5e-09 35.8 0.6 4.5e-09 35.8 0.4 3.2 3 0 0 3 3 3 1 SNARE domain V-SNARE_C PF12352.3 ESA18143.1 - 0.00021 21.2 7.8 0.0078 16.2 0.6 2.9 2 1 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Mit_KHE1 PF10173.4 ESA18143.1 - 0.23 11.2 3.1 0.42 10.4 2.2 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Laminin_II PF06009.7 ESA18143.1 - 0.29 10.9 11.8 0.52 10.0 0.5 2.9 2 1 1 3 3 3 0 Laminin Domain II DDHD PF02862.12 ESA18143.1 - 4.4 7.0 12.8 2.2 8.0 7.1 1.7 1 1 0 1 1 1 0 DDHD domain RasGAP_C PF03836.10 ESA18143.1 - 5.1 6.7 12.4 0.35 10.5 0.3 3.0 1 1 2 3 3 3 0 RasGAP C-terminus DUF2335 PF10097.4 ESA18143.1 - 7 6.3 7.6 2.5 7.7 0.0 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2335) tRNA-synt_His PF13393.1 ESA18144.1 - 2.7e-39 135.0 0.0 2.9e-35 121.8 0.0 2.2 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 ESA18144.1 - 4.2e-19 68.7 0.0 7.3e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA18144.1 - 7e-16 57.9 0.0 1.6e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain WHEP-TRS PF00458.15 ESA18144.1 - 6.2e-09 35.3 8.9 6.2e-09 35.3 6.2 1.9 2 0 0 2 2 2 1 WHEP-TRS domain tRNA-synt_2 PF00152.15 ESA18144.1 - 3.2e-06 26.1 0.0 9.3e-05 21.3 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 ESA18144.1 - 0.037 13.2 0.0 0.081 12.1 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) HAD PF12710.2 ESA18145.1 - 1.3e-19 71.1 0.0 7.5e-19 68.6 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 ESA18145.1 - 3.4e-19 68.8 0.0 7.2e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 ESA18145.1 - 6e-15 56.2 1.4 1.1e-13 52.0 1.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA18145.1 - 9.7e-14 51.1 0.0 2.8e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 ESA18145.1 - 0.001 18.7 0.1 0.017 14.6 0.0 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA18145.1 - 0.038 14.2 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RRM_1 PF00076.17 ESA18146.1 - 6e-10 38.6 0.0 1.3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18146.1 - 2.1e-08 34.0 0.0 3.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18146.1 - 9.4e-05 22.1 0.0 0.00026 20.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA18146.1 - 0.088 12.6 0.4 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 RNA binding motif Laminin_G_1 PF00054.18 ESA18146.1 - 0.11 12.5 1.9 0.36 10.8 0.1 2.4 3 0 0 3 3 3 0 Laminin G domain Cupin_8 PF13621.1 ESA18147.1 - 1.6e-38 132.6 0.2 3.6e-38 131.5 0.0 1.6 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.7 ESA18147.1 - 4.9e-07 29.2 0.0 1.2e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Cupin superfamily protein Ribul_P_3_epim PF00834.14 ESA18147.1 - 0.0005 19.2 0.0 0.00082 18.5 0.0 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family PNK3P PF08645.6 ESA18148.1 - 1.2e-55 187.3 1.3 1.3e-55 187.1 0.2 1.6 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.1 ESA18148.1 - 1.6e-27 96.1 0.0 1.3e-25 89.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA18148.1 - 9.2e-07 28.1 0.0 0.00027 20.0 0.0 2.6 2 1 1 3 3 3 2 Zeta toxin KTI12 PF08433.5 ESA18148.1 - 0.0045 16.2 4.1 0.32 10.1 0.0 3.0 2 1 1 3 3 3 2 Chromatin associated protein KTI12 Hydrolase_6 PF13344.1 ESA18148.1 - 0.0053 16.6 1.5 0.16 11.8 0.0 3.0 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase AAA_17 PF13207.1 ESA18148.1 - 0.0055 17.5 0.4 0.087 13.6 0.0 2.8 2 2 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 ESA18148.1 - 0.014 15.3 0.0 0.054 13.4 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.1 ESA18148.1 - 0.039 14.2 2.9 8.1 6.7 0.0 3.8 2 2 2 4 4 4 0 AAA domain CobU PF02283.11 ESA18148.1 - 0.11 11.8 0.0 7.9 5.8 0.0 2.3 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase tRNA-synt_1b PF00579.20 ESA18149.1 - 7.3e-24 84.3 0.0 4.4e-18 65.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Methyltransf_11 PF08241.7 ESA18153.1 - 1.2e-11 44.8 0.0 1.9e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18153.1 - 3.1e-10 39.8 0.1 1.6e-08 34.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18153.1 - 5e-09 36.0 0.0 6.5e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18153.1 - 5.1e-08 33.2 0.0 8.1e-07 29.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18153.1 - 9.9e-06 24.8 0.0 0.00051 19.2 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA18153.1 - 4.2e-05 24.0 0.0 0.0004 20.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA18153.1 - 0.00012 21.2 0.1 0.00086 18.5 0.1 1.9 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.7 ESA18153.1 - 0.00014 22.2 0.0 0.004 17.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA18153.1 - 0.00032 20.7 0.0 0.00037 20.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase MetW PF07021.7 ESA18153.1 - 0.00049 19.5 0.0 0.00076 18.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_26 PF13659.1 ESA18153.1 - 0.00067 19.6 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA18153.1 - 0.0018 17.3 0.0 0.0027 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.10 ESA18153.1 - 0.01 15.4 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 0 Hypothetical methyltransferase RrnaAD PF00398.15 ESA18153.1 - 0.031 13.2 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.15 ESA18153.1 - 0.06 12.4 0.0 0.094 11.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.9 ESA18153.1 - 0.062 12.6 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_29 PF03141.11 ESA18153.1 - 0.11 10.8 0.0 0.62 8.3 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DAP3 PF10236.4 ESA18154.1 - 1.7e-22 79.8 0.0 2.3e-22 79.3 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 G-gamma PF00631.17 ESA18154.1 - 0.049 13.3 0.0 8.9 6.1 0.0 2.8 1 1 2 3 3 3 0 GGL domain Methyltransf_11 PF08241.7 ESA18155.1 - 4.4e-08 33.4 0.0 7.7e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18155.1 - 1.4e-07 31.8 0.0 2.3e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18155.1 - 2e-07 30.6 0.2 1.5e-06 27.9 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18155.1 - 4e-07 29.8 0.0 5.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA18155.1 - 1.2e-05 24.7 0.0 1.6e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA18155.1 - 0.00044 20.7 0.0 0.001 19.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA18155.1 - 0.00058 19.0 0.0 0.00078 18.6 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 ESA18155.1 - 0.00095 18.2 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA18155.1 - 0.0021 18.0 0.0 0.0048 16.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA18155.1 - 0.011 16.1 0.1 0.026 15.0 0.0 1.7 2 1 0 2 2 1 0 Methyltransferase domain FtsJ PF01728.14 ESA18155.1 - 0.027 14.4 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.13 ESA18155.1 - 0.073 12.2 0.0 0.092 11.9 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase MTS PF05175.9 ESA18155.1 - 0.077 12.3 0.0 0.12 11.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 ESA18155.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.7 ESA18156.1 - 4.1e-13 49.6 0.0 8.3e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18156.1 - 3.9e-12 46.0 0.1 1.8e-11 43.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18156.1 - 3.5e-10 39.8 0.0 5.2e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18156.1 - 6.8e-10 39.2 0.0 1.3e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18156.1 - 6.7e-07 29.8 0.0 4.7e-06 27.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18156.1 - 7.7e-07 28.4 0.0 6.4e-06 25.4 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family MetW PF07021.7 ESA18156.1 - 4.4e-06 26.2 0.0 8.3e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.9 ESA18156.1 - 2.4e-05 23.5 0.1 0.00015 20.9 0.1 2.2 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.7 ESA18156.1 - 4.2e-05 23.9 0.0 0.00018 21.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA18156.1 - 6.2e-05 22.1 0.0 0.00018 20.6 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 ESA18156.1 - 0.00011 22.2 0.0 0.00025 21.0 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA18156.1 - 0.0039 17.2 0.0 0.0093 15.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 ESA18156.1 - 0.0094 15.1 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_8 PF05148.10 ESA18156.1 - 0.019 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.15 ESA18156.1 - 0.023 13.7 0.0 0.042 12.9 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TAFII55_N PF04658.8 ESA18158.1 - 7.5e-42 142.5 1.7 1e-41 142.1 1.2 1.1 1 0 0 1 1 1 1 TAFII55 protein conserved region JAB PF01398.16 ESA18160.1 - 5.3e-18 64.8 0.0 8.8e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.6 ESA18160.1 - 4.5e-15 55.6 0.9 1e-14 54.4 0.6 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.1 ESA18160.1 - 4.7e-07 29.3 0.0 8.7e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain NPL4 PF05021.10 ESA18160.1 - 0.1 11.7 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 NPL4 family Mt_ATP-synt_D PF05873.7 ESA18161.1 - 1.6e-12 47.4 2.8 1.8e-12 47.1 2.0 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF3158 PF11358.3 ESA18161.1 - 0.029 13.8 1.2 0.048 13.1 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3158) PEP-utilisers_N PF05524.8 ESA18161.1 - 0.24 11.2 3.4 0.41 10.4 0.3 2.1 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Hydrolase_3 PF08282.7 ESA18161.1 - 0.25 10.8 4.8 0.33 10.4 3.3 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF2408 PF10303.4 ESA18161.1 - 0.28 11.2 2.9 0.74 9.9 2.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF3708 PF12501.3 ESA18161.1 - 0.32 10.8 1.2 0.55 10.0 0.5 1.5 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter KapB PF08810.5 ESA18161.1 - 0.35 10.9 2.2 0.33 10.9 0.7 1.5 2 0 0 2 2 2 0 Kinase associated protein B DUF908 PF06012.7 ESA18161.1 - 0.39 9.9 3.3 0.52 9.5 2.3 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF2570 PF10828.3 ESA18161.1 - 1.2 8.8 7.3 4.7 6.8 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) HR1 PF02185.11 ESA18161.1 - 1.2 8.9 4.7 5.1 6.9 1.3 2.7 2 1 0 2 2 2 0 Hr1 repeat PhoU PF01895.14 ESA18161.1 - 2.2 8.8 7.9 3.1 8.3 0.9 2.4 1 1 1 2 2 2 0 PhoU domain EST1 PF10374.4 ESA18162.1 - 0.83 9.6 8.5 0.14 12.1 0.4 3.2 2 1 1 3 3 3 0 Telomerase activating protein Est1 ERp29 PF07749.7 ESA18162.1 - 1.4 9.5 12.5 3.1 8.4 5.7 3.4 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Zn_clus PF00172.13 ESA18163.1 - 2.7e-08 33.5 46.9 0.00015 21.5 12.8 2.7 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Spore_III_AF PF09581.5 ESA18163.1 - 0.16 11.7 6.6 0.11 12.3 3.3 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) AAA PF00004.24 ESA18164.1 - 5.2e-07 29.9 0.9 2.7e-05 24.3 0.6 2.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA12 PF10443.4 ESA18164.1 - 6.3e-07 28.2 1.1 1e-06 27.5 0.7 1.3 1 0 0 1 1 1 1 RNA12 protein AAA_22 PF13401.1 ESA18164.1 - 7.3e-06 26.1 0.3 4.3e-05 23.6 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA18164.1 - 0.00014 22.1 2.8 0.00039 20.7 0.0 2.7 1 1 1 2 2 2 1 AAA domain NACHT PF05729.7 ESA18164.1 - 0.00032 20.3 0.0 0.00066 19.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 ESA18164.1 - 0.00041 19.7 0.0 0.003 16.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA18164.1 - 0.0011 18.8 2.5 0.032 14.1 0.7 3.1 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 ESA18164.1 - 0.011 15.5 0.1 1.1 8.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) CGI-121 PF08617.5 ESA18164.1 - 0.025 14.2 1.1 0.08 12.6 0.8 1.9 1 1 0 1 1 1 0 Kinase binding protein CGI-121 ABC_tran PF00005.22 ESA18164.1 - 0.028 14.6 0.2 0.095 13.0 0.1 2.0 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.1 ESA18164.1 - 0.032 14.2 0.0 0.18 11.7 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.7 ESA18164.1 - 0.044 12.8 0.0 0.16 10.9 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus SecA_PP_bind PF01043.15 ESA18164.1 - 0.097 13.0 0.6 0.63 10.4 0.2 2.3 2 0 0 2 2 2 0 SecA preprotein cross-linking domain NTPase_1 PF03266.10 ESA18164.1 - 0.14 11.8 2.5 2.4 7.8 1.7 2.6 1 1 0 1 1 1 0 NTPase Orthopox_F8 PF05886.6 ESA18165.1 - 0.069 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Orthopoxvirus F8 protein MMR_HSR1 PF01926.18 ESA18166.1 - 3.4e-08 33.4 0.1 2e-07 30.9 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA18166.1 - 2.7e-06 26.6 0.0 9.5e-06 24.8 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA18166.1 - 0.00091 18.7 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 ESA18166.1 - 0.0012 19.0 0.0 0.2 11.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.22 ESA18166.1 - 0.0062 15.9 0.0 0.029 13.8 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.1 ESA18166.1 - 0.019 15.2 0.0 0.019 15.2 0.0 4.2 3 2 1 4 4 3 0 AAA domain GUCT PF08152.7 ESA18166.1 - 0.026 14.5 0.7 0.098 12.6 0.5 2.0 1 0 0 1 1 1 0 GUCT (NUC152) domain T2SE PF00437.15 ESA18166.1 - 0.027 13.3 0.6 0.083 11.7 0.0 2.1 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_17 PF13207.1 ESA18166.1 - 0.034 14.9 1.5 0.26 12.1 0.0 3.2 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA18166.1 - 0.04 13.3 0.0 0.095 12.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.22 ESA18166.1 - 0.057 13.7 0.0 0.057 13.7 0.0 3.5 3 1 0 3 3 3 0 ABC transporter AAA_16 PF13191.1 ESA18166.1 - 0.083 12.8 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 ESA18166.1 - 0.41 10.8 0.0 0.41 10.8 0.0 3.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.18 ESA18166.1 - 1.7 8.4 10.2 6.3 6.5 0.0 4.3 2 1 2 4 4 3 0 Dynamin family Smg4_UPF3 PF03467.10 ESA18168.1 - 9.4e-38 129.9 0.2 1.6e-37 129.2 0.2 1.3 1 0 0 1 1 1 1 Smg-4/UPF3 family DUF1764 PF08576.5 ESA18169.1 - 1.4e-17 64.3 11.8 2.7e-16 60.1 8.2 2.0 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Aerolysin PF01117.15 ESA18169.1 - 0.75 8.6 3.4 0.93 8.3 2.4 1.0 1 0 0 1 1 1 0 Aerolysin toxin CH PF00307.26 ESA18170.1 - 2.3e-72 239.9 0.8 6.7e-21 74.3 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.3 ESA18170.1 - 8.1e-09 35.0 0.1 3.9e-05 23.2 0.0 4.0 4 0 0 4 4 4 1 CAMSAP CH domain EF-hand_7 PF13499.1 ESA18170.1 - 1.1e-07 31.8 1.2 4e-07 30.0 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 ESA18170.1 - 2.1e-05 23.5 0.4 0.032 13.5 0.0 3.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 ESA18170.1 - 0.00029 20.4 0.3 0.0028 17.3 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 ESA18170.1 - 0.016 14.8 0.0 0.64 9.6 0.0 2.7 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.1 ESA18170.1 - 0.059 12.7 0.2 0.27 10.6 0.0 2.3 2 0 0 2 2 2 0 EF hand Peptidase_M16 PF00675.15 ESA18171.1 - 3.9e-55 185.6 1.3 2e-54 183.3 0.6 2.3 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 ESA18171.1 - 9.8e-46 155.7 0.2 2.1e-44 151.4 0.0 2.5 3 0 0 3 3 3 1 Peptidase M16 inactive domain CENP-O PF09496.5 ESA18171.1 - 0.12 12.6 0.0 0.38 11.0 0.0 1.9 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component IBR PF01485.16 ESA18172.1 - 6.5e-19 67.5 47.7 2.1e-12 46.6 5.3 5.1 3 1 2 5 5 5 2 IBR domain RWD PF05773.17 ESA18172.1 - 1.2e-06 28.4 0.4 5.4e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 RWD domain zf-RING_2 PF13639.1 ESA18172.1 - 2.3e-06 27.3 8.8 2.3e-06 27.3 6.1 4.7 4 1 0 4 4 4 2 Ring finger domain zf-RING_5 PF14634.1 ESA18172.1 - 4.5e-05 23.0 9.6 4.5e-05 23.0 6.7 4.6 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA18172.1 - 0.0044 16.9 9.7 0.0044 16.9 6.8 5.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA18172.1 - 0.011 15.4 9.4 0.011 15.4 6.5 4.9 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA18172.1 - 0.02 14.6 5.4 0.02 14.6 3.7 3.2 2 1 0 2 2 2 0 RING-type zinc-finger DUF4599 PF15371.1 ESA18172.1 - 0.69 10.0 4.4 2 8.5 0.0 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4599) rve PF00665.21 ESA18175.1 - 4.8e-05 23.4 0.0 7.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.14 ESA18176.1 - 1.4e-06 27.6 0.0 1.4e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease ALMT PF11744.3 ESA18177.1 - 0.1 11.2 0.5 0.46 9.0 0.3 1.9 1 1 0 1 1 1 0 Aluminium activated malate transporter Cytochrom_c3_2 PF14537.1 ESA18177.1 - 0.16 12.3 7.1 0.13 12.6 2.8 2.2 2 0 0 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.1 ESA18177.1 - 0.16 11.6 5.1 0.35 10.5 3.5 1.6 1 0 0 1 1 1 0 Cytochrome c7 Paired_CXXCH_1 PF09699.5 ESA18177.1 - 0.8 9.2 3.4 2 8.0 2.1 1.8 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-CHY PF05495.7 ESA18177.1 - 1.8 8.7 10.5 0.2 11.8 3.7 2.0 2 0 0 2 2 2 0 CHY zinc finger DUF2373 PF10180.4 ESA18178.1 - 7.9e-19 66.9 3.6 8.3e-19 66.8 1.7 1.6 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2373) Borrelia_P83 PF05262.6 ESA18178.1 - 0.0029 15.9 1.2 0.0042 15.4 0.8 1.3 1 0 0 1 1 1 1 Borrelia P83/100 protein WASH-7_C PF14746.1 ESA18178.1 - 4.3 6.9 7.0 0.25 10.9 0.7 1.8 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal DUF457 PF04307.9 ESA18179.1 - 0.00073 18.9 5.9 0.00073 18.9 4.1 1.9 1 1 0 1 1 1 1 Predicted membrane-bound metal-dependent hydrolase (DUF457) Fe-S_assembly PF04384.8 ESA18180.1 - 0.014 15.7 0.0 5.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Iron-sulphur cluster assembly Ndr PF03096.9 ESA18182.1 - 0.049 12.1 1.9 0.058 11.8 0.9 1.4 1 1 0 1 1 1 0 Ndr family RAI1 PF08652.6 ESA18182.1 - 1.6 8.5 6.0 0.61 9.9 0.1 2.8 2 1 1 3 3 3 0 RAI1 like PD-(D/E)XK nuclease HTH_Tnp_Tc5 PF03221.11 ESA18183.1 - 5.1e-10 39.0 0.3 1.7e-09 37.3 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain Me-amine-dh_H PF06433.6 ESA18183.1 - 0.038 12.6 0.2 0.046 12.3 0.2 1.1 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Response_reg PF00072.19 ESA18184.1 - 9.1e-06 25.6 0.1 0.0088 16.0 0.0 2.2 2 0 0 2 2 2 2 Response regulator receiver domain DUF3881 PF12997.2 ESA18185.1 - 0.0023 16.9 0.2 0.0027 16.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3881) ACT_4 PF13291.1 ESA18185.1 - 0.016 15.5 2.1 0.019 15.3 0.5 1.7 2 0 0 2 2 2 0 ACT domain DUF3023 PF11224.3 ESA18185.1 - 0.061 12.9 0.8 0.13 11.9 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3023) tRNA-synt_1f PF01921.13 ESA18185.1 - 0.085 11.5 0.0 0.092 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (K) Adeno_E3A PF05248.7 ESA18185.1 - 0.11 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E3A Response_reg PF00072.19 ESA18186.1 - 0.05 13.6 0.0 0.063 13.2 0.0 1.1 1 0 0 1 1 1 0 Response regulator receiver domain APG12 PF04110.8 ESA18187.1 - 1.9e-35 120.9 0.1 2.5e-35 120.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.11 ESA18187.1 - 0.00011 22.1 0.0 0.00013 21.8 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Erf4 PF10256.4 ESA18188.1 - 7.2e-31 106.4 0.3 1.3e-30 105.6 0.2 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family PIG-H PF10181.4 ESA18189.1 - 0.058 13.0 1.3 0.2 11.3 0.5 2.2 2 0 0 2 2 2 0 GPI-GlcNAc transferase complex, PIG-H component Adap_comp_sub PF00928.16 ESA18190.1 - 7.8e-06 25.1 0.0 8.3e-06 25.0 0.0 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Mito_carr PF00153.22 ESA18191.1 - 9.9e-67 220.7 3.4 4.1e-22 77.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aminotran_1_2 PF00155.16 ESA18192.1 - 2.3e-37 128.8 0.0 5.5e-37 127.5 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESA18192.1 - 0.011 14.8 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase TraT PF05818.7 ESA18193.1 - 0.00052 19.4 0.4 0.16 11.3 0.0 2.2 2 0 0 2 2 2 2 Enterobacterial TraT complement resistance protein Fer4_8 PF13183.1 ESA18193.1 - 0.00062 19.7 0.2 0.065 13.2 0.0 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 ESA18193.1 - 0.0011 18.7 2.0 0.14 12.0 0.3 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 ESA18193.1 - 0.003 17.8 2.6 0.059 13.7 0.5 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 ESA18193.1 - 0.0043 17.4 0.2 0.66 10.4 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESA18193.1 - 0.028 14.6 3.0 1.2 9.4 0.4 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Choline_sulf_C PF12411.3 ESA18193.1 - 4 7.3 6.3 3.4 7.5 0.6 2.3 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal Dimer_Tnp_hAT PF05699.9 ESA18195.1 - 4.5e-08 32.6 0.4 2.5e-05 23.7 0.1 2.4 2 0 0 2 2 2 2 hAT family C-terminal dimerisation region PI31_Prot_N PF11566.3 ESA18197.1 - 0.029 13.9 1.6 0.096 12.2 0.2 2.1 1 1 1 2 2 2 0 PI31 proteasome regulator N-terminal HMG_box PF00505.14 ESA18198.1 - 6.2e-10 39.1 4.5 9.3e-10 38.6 3.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18198.1 - 1.7e-08 34.6 4.9 2.3e-08 34.2 3.4 1.2 1 0 0 1 1 1 1 HMG-box domain Rhabdo_NV PF02484.10 ESA18198.1 - 0.054 13.3 0.1 0.066 13.0 0.1 1.2 1 0 0 1 1 1 0 Rhabdovirus Non-virion protein Toxin_41 PF15521.1 ESA18198.1 - 0.22 10.6 1.0 0.28 10.3 0.7 1.1 1 0 0 1 1 1 0 Putative toxin 41 Transposase_21 PF02992.9 ESA18200.1 - 1.1e-09 37.7 0.3 1.2e-09 37.6 0.2 1.2 1 0 0 1 1 1 1 Transposase family tnp2 Sel1 PF08238.7 ESA18206.1 - 8.7e-128 413.9 75.8 9.4e-12 45.1 0.5 12.1 12 0 0 12 12 12 12 Sel1 repeat MIT PF04212.13 ESA18206.1 - 4.7e-09 35.9 53.0 0.21 11.4 0.1 11.3 10 2 2 12 12 12 7 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA18206.1 - 9.9e-08 31.9 45.3 0.38 11.3 0.1 10.9 12 0 0 12 12 12 5 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA18206.1 - 7.9e-07 28.6 18.0 5.9 6.6 0.0 10.1 12 0 0 12 12 12 1 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA18206.1 - 1.9e-06 27.6 35.1 6.3 7.2 0.1 11.4 10 1 0 10 10 10 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA18206.1 - 0.0065 16.5 7.3 6.7 6.8 0.0 5.5 2 2 3 7 7 7 1 Tetratricopeptide repeat HTH_16 PF12645.2 ESA18206.1 - 0.84 9.6 5.4 25 4.8 0.0 4.0 4 0 0 4 4 4 0 Helix-turn-helix domain Glu_syn_central PF04898.9 ESA18206.1 - 8.1 5.6 10.3 75 2.4 0.0 5.3 3 2 2 6 6 6 0 Glutamate synthase central domain DUF4419 PF14388.1 ESA18210.1 - 1.7e-22 80.0 0.4 2.4e-22 79.5 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4419) Dimer_Tnp_hAT PF05699.9 ESA18211.1 - 1e-15 57.0 0.0 1.1e-15 56.9 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Mg_trans_NIPA PF05653.9 ESA18212.1 - 3.7e-61 206.7 16.1 5e-61 206.2 11.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF340 PF03956.8 ESA18212.1 - 0.0091 15.3 4.1 0.0091 15.3 2.9 1.9 1 1 0 2 2 2 1 Membrane protein of unknown function (DUF340) EamA PF00892.15 ESA18212.1 - 0.082 12.9 0.3 0.082 12.9 0.2 3.4 2 1 1 3 3 3 0 EamA-like transporter family DUF1282 PF06930.7 ESA18212.1 - 0.24 11.0 14.6 0.4 10.3 10.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) MgtC PF02308.11 ESA18212.1 - 7 6.4 9.2 0.43 10.4 1.4 2.2 1 1 0 2 2 2 0 MgtC family Dsh_C PF12316.3 ESA18213.1 - 0.18 11.8 8.9 0.24 11.5 6.1 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Tmemb_cc2 PF10267.4 ESA18213.1 - 0.27 9.7 6.9 0.3 9.6 4.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Mitofilin PF09731.4 ESA18213.1 - 0.45 9.1 6.8 0.5 8.9 4.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.4 ESA18213.1 - 8.9 4.4 11.6 9.2 4.4 8.1 1.0 1 0 0 1 1 1 0 Transmembrane protein RAP1 PF07218.6 ESA18213.1 - 9 4.2 9.8 10 4.0 6.8 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1741 PF08427.5 ESA18214.1 - 0.041 13.3 1.5 0.046 13.1 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1741) HMG_box PF00505.14 ESA18215.1 - 0.00049 20.3 0.2 0.0011 19.2 0.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18215.1 - 0.0012 19.2 0.1 0.0025 18.1 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain KBP_C PF12309.3 ESA18215.1 - 0.032 13.1 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 KIF-1 binding protein C terminal EI24 PF07264.6 ESA18216.1 - 9.4e-07 28.4 17.8 0.0025 17.2 12.4 2.4 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Rab5ip PF07019.7 ESA18216.1 - 0.12 12.5 0.0 0.12 12.5 0.0 3.3 3 1 0 3 3 3 0 Rab5-interacting protein (Rab5ip) MPLKIP PF15502.1 ESA18217.1 - 4.9e-08 33.8 24.4 7.7e-08 33.1 16.9 1.5 1 1 0 1 1 1 1 M-phase-specific PLK1-interacting protein Rtt106 PF08512.7 ESA18218.1 - 1.7e-22 79.2 0.0 2.5e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DUF3956 PF13104.1 ESA18218.1 - 0.0043 16.5 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3956) YEATS PF03366.11 ESA18219.1 - 9.6e-25 86.1 0.1 1.6e-24 85.4 0.1 1.3 1 0 0 1 1 1 1 YEATS family DUF4419 PF14388.1 ESA18220.1 - 4.2e-23 82.0 0.2 5.1e-23 81.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) BTB PF00651.26 ESA18222.1 - 3.7e-21 75.1 0.1 7.2e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA18222.1 - 4.1e-13 49.5 1.7 9e-13 48.4 1.2 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA18222.1 - 9.9e-07 28.5 4.8 4.3e-06 26.4 0.4 3.4 3 1 1 4 4 4 1 BTB And C-terminal Kelch GDE_C PF06202.9 ESA18222.1 - 0.032 12.9 0.0 0.05 12.3 0.0 1.3 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Arch_ATPase PF01637.13 ESA18228.1 - 3.4e-16 59.6 0.6 1e-15 58.0 0.0 2.0 2 0 0 2 2 2 1 Archaeal ATPase AAA_22 PF13401.1 ESA18228.1 - 2.4e-08 34.1 0.0 5.9e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 ESA18228.1 - 1.7e-07 31.5 0.0 3.8e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA12 PF10443.4 ESA18228.1 - 2.2e-05 23.1 0.1 0.12 10.8 0.0 2.1 2 0 0 2 2 2 2 RNA12 protein AAA_14 PF13173.1 ESA18228.1 - 0.00012 21.9 0.1 0.0011 18.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA18228.1 - 0.0015 18.8 1.4 0.015 15.5 0.0 2.7 2 2 1 3 3 3 1 AAA domain AAA_16 PF13191.1 ESA18228.1 - 0.0035 17.3 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Miro PF08477.8 ESA18228.1 - 0.0043 17.5 0.0 0.23 11.9 0.0 2.5 1 1 0 1 1 1 1 Miro-like protein MobB PF03205.9 ESA18228.1 - 0.0092 15.6 0.0 0.043 13.5 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 ESA18228.1 - 0.024 15.4 0.0 0.085 13.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.1 ESA18228.1 - 0.047 13.2 0.0 0.13 11.7 0.0 1.7 1 1 0 2 2 2 0 AAA domain Delta_lysin PF05372.6 ESA18228.1 - 0.068 12.5 1.3 12 5.3 0.0 3.7 3 0 0 3 3 3 0 Delta lysin family MMR_HSR1 PF01926.18 ESA18228.1 - 0.07 13.0 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.1 ESA18228.1 - 0.085 13.1 2.4 0.79 10.0 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.1 ESA18228.1 - 0.092 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 ESA18228.1 - 0.092 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESA18228.1 - 0.11 11.8 0.0 4.1 6.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 ESA18228.1 - 0.23 11.2 0.1 0.47 10.2 0.1 1.4 1 0 0 1 1 1 0 Part of AAA domain DUF4066 PF13278.1 ESA18229.1 - 2.6e-32 111.4 0.0 3e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 ESA18229.1 - 3.4e-15 55.7 0.0 4.6e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family EphA2_TM PF14575.1 ESA18231.1 - 0.061 13.7 0.1 0.061 13.7 0.1 3.1 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain BatA PF07584.6 ESA18231.1 - 0.55 10.4 4.0 0.35 11.1 0.9 2.1 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal OAD_gamma PF04277.8 ESA18231.1 - 1.1 9.6 4.8 0.57 10.5 0.5 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PTH2 PF01981.11 ESA18233.1 - 0.0098 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Pkinase_Tyr PF07714.12 ESA18233.1 - 0.04 12.9 0.0 0.082 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein tyrosine kinase Pkinase PF00069.20 ESA18234.1 - 9.3e-43 146.2 1.0 1.4e-42 145.6 0.0 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18234.1 - 1.1e-38 132.8 0.0 1.8e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18234.1 - 0.21 11.2 0.5 0.34 10.5 0.3 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.2 ESA18235.1 - 0.00061 19.4 0.2 0.0012 18.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like Anemone_cytotox PF06369.7 ESA18235.1 - 0.024 14.0 0.2 0.048 13.0 0.1 1.4 1 0 0 1 1 1 0 Sea anemone cytotoxic protein DUF829 PF05705.9 ESA18238.1 - 1.7e-22 80.3 0.0 2.2e-21 76.6 0.0 2.6 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Arena_glycoprot PF00798.13 ESA18239.1 - 0.026 12.9 1.7 0.04 12.3 1.2 1.2 1 0 0 1 1 1 0 Arenavirus glycoprotein DUF4428 PF14471.1 ESA18241.1 - 0.0079 15.9 1.8 0.0079 15.9 1.3 3.8 3 1 0 3 3 3 1 Domain of unknown function (DUF4428) FYVE PF01363.16 ESA18241.1 - 0.011 15.5 6.8 0.44 10.4 0.0 2.6 2 1 0 2 2 2 0 FYVE zinc finger DZR PF12773.2 ESA18241.1 - 0.029 14.1 4.0 3.9 7.3 0.1 2.6 2 1 0 2 2 2 0 Double zinc ribbon Receptor_2B4 PF11465.3 ESA18241.1 - 0.034 14.0 0.2 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 CAMSAP_CKK PF08683.6 ESA18241.1 - 0.04 13.6 0.2 0.058 13.1 0.2 1.3 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated UPF0167 PF03691.9 ESA18241.1 - 0.11 11.9 5.6 1.3 8.3 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0167) zf-BED PF02892.10 ESA18241.1 - 0.42 10.4 10.6 1.1 9.1 0.3 3.4 3 0 0 3 3 3 0 BED zinc finger C1_1 PF00130.17 ESA18241.1 - 0.52 10.0 7.4 0.75 9.5 0.2 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.20 ESA18243.1 - 2.1e-11 43.4 0.0 7e-09 35.2 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain APH PF01636.18 ESA18243.1 - 0.012 15.3 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA18243.1 - 0.03 13.3 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.9 ESA18243.1 - 0.067 12.2 0.0 0.095 11.7 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH_6_hur PF04655.9 ESA18243.1 - 0.084 12.0 0.1 0.15 11.2 0.1 1.4 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Pkinase PF00069.20 ESA18244.1 - 4.3e-08 32.6 0.0 6.1e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18244.1 - 0.019 14.7 0.1 0.031 14.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA18244.1 - 0.049 12.6 0.2 0.21 10.6 0.0 1.8 1 1 0 2 2 2 0 Protein tyrosine kinase APH_6_hur PF04655.9 ESA18244.1 - 0.12 11.4 0.2 0.17 10.9 0.1 1.3 1 1 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase SAM_1 PF00536.25 ESA18245.1 - 0.00019 21.5 0.0 0.00026 21.1 0.0 1.3 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 ESA18245.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Syntaxin-6_N PF09177.6 ESA18248.1 - 0.43 11.0 5.6 5.7 7.4 3.8 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Ndc1_Nup PF09531.5 ESA18248.1 - 3.4 5.9 10.3 4.1 5.7 7.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.4 ESA18248.1 - 5.5 5.1 10.8 7.7 4.6 7.5 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF2075 PF09848.4 ESA18251.1 - 0.15 10.9 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3404 PF11884.3 ESA18252.1 - 0.015 14.2 0.2 0.025 13.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) Uso1_p115_head PF04869.9 ESA18252.1 - 0.041 12.6 0.1 0.058 12.1 0.1 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region DUF2316 PF10078.4 ESA18252.1 - 0.042 13.8 2.4 0.071 13.1 1.4 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) DNA_pol3_tau_4 PF12168.3 ESA18252.1 - 0.091 13.1 5.3 0.17 12.2 3.6 1.5 1 0 0 1 1 1 0 DNA polymerase III subunits tau domain IV DnaB-binding DUF2570 PF10828.3 ESA18252.1 - 0.29 10.7 7.0 0.64 9.6 4.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) GAS PF13851.1 ESA18252.1 - 0.54 9.4 21.4 0.66 9.1 11.7 2.2 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4094 PF13334.1 ESA18252.1 - 0.99 9.8 5.5 5 7.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Abhydrolase_3 PF07859.8 ESA18253.1 - 1.3e-07 31.4 0.3 0.00014 21.4 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold FAD_binding_3 PF01494.14 ESA18256.1 - 5.2e-16 58.6 0.0 5.1e-11 42.2 0.0 3.1 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ESA18256.1 - 0.00017 21.5 0.0 0.00037 20.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA18256.1 - 0.00042 20.1 0.0 0.0012 18.6 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA18256.1 - 0.00099 19.2 0.0 0.0041 17.2 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 ESA18256.1 - 0.12 11.2 0.0 1.5 7.7 0.0 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein LRR_8 PF13855.1 ESA18257.1 - 3.1 7.6 17.3 1.9 8.2 2.3 4.9 2 2 5 7 7 7 0 Leucine rich repeat F-box-like PF12937.2 ESA18258.1 - 0.00015 21.4 0.2 0.00091 18.9 0.0 2.4 2 0 0 2 2 2 1 F-box-like HMG_box PF00505.14 ESA18259.1 - 1.6e-08 34.6 1.4 4.1e-08 33.3 0.9 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18259.1 - 0.00012 22.3 0.8 0.00026 21.2 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain Peptidase_S64 PF08192.6 ESA18259.1 - 7.7 4.7 8.2 9 4.4 5.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Sel1 PF08238.7 ESA18261.1 - 1.2e-69 229.1 4.5 6.5e-10 39.3 0.0 7.2 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA18261.1 - 4.9e-11 42.3 6.1 0.07 13.6 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18261.1 - 3e-09 36.3 1.2 1.4 9.2 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18261.1 - 0.096 13.3 0.1 38 5.1 0.0 3.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Chordopox_A13L PF05961.6 ESA18261.1 - 0.11 12.4 12.4 54 3.8 0.0 6.5 6 2 1 7 7 7 0 Chordopoxvirus A13L protein TPR_11 PF13414.1 ESA18261.1 - 0.14 11.8 24.6 2 8.1 0.7 6.0 1 1 6 7 7 7 0 TPR repeat NADPH_Ox PF08414.5 ESA18261.1 - 0.18 11.9 2.7 2.8 8.0 0.0 3.5 4 1 0 4 4 4 0 Respiratory burst NADPH oxidase TPR_5 PF12688.2 ESA18261.1 - 1.1 9.2 5.5 59 3.7 0.1 4.0 4 1 1 5 5 5 0 Tetratrico peptide repeat Pkinase_Tyr PF07714.12 ESA18263.1 - 7.2e-26 90.8 1.0 1.3e-25 89.9 0.7 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18263.1 - 1.3e-19 70.3 6.5 3.5e-19 68.9 4.5 1.7 1 1 0 1 1 1 1 Protein kinase domain UPF0118 PF01594.11 ESA18264.1 - 0.0049 15.8 0.4 0.0052 15.8 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF20 Ribosomal_L14 PF00238.14 ESA18264.1 - 0.016 14.9 0.1 0.018 14.8 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L14p/L23e DUF3543 PF12063.3 ESA18264.1 - 0.17 11.0 0.9 9.6 5.3 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3543) DBD_Tnp_Mut PF03108.10 ESA18265.1 - 0.095 12.2 0.0 0.41 10.2 0.0 1.9 2 0 0 2 2 2 0 MuDR family transposase FAR1 PF03101.10 ESA18266.1 - 7.5e-08 32.7 1.4 7.5e-08 32.7 0.9 1.9 2 0 0 2 2 2 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA18266.1 - 0.01 15.3 6.7 2.3 7.8 3.0 2.7 2 0 0 2 2 2 0 MuDR family transposase Psb28 PF03912.9 ESA18266.1 - 0.029 14.3 0.1 0.079 12.9 0.1 1.8 1 0 0 1 1 1 0 Psb28 protein Nop14 PF04147.7 ESA18266.1 - 0.095 10.6 5.9 0.14 10.0 4.1 1.1 1 0 0 1 1 1 0 Nop14-like family BTB_2 PF02214.17 ESA18268.1 - 3e-19 69.0 1.3 6.2e-18 64.7 0.1 2.3 1 1 1 2 2 2 2 BTB/POZ domain CMAS PF02353.15 ESA18269.1 - 1.4e-38 132.5 0.6 1.8e-38 132.1 0.4 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.1 ESA18269.1 - 2.9e-16 59.4 0.0 5.6e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18269.1 - 3.6e-14 53.2 0.0 7.9e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA18269.1 - 7e-14 52.0 0.0 1.7e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18269.1 - 9.9e-13 48.1 0.0 1.7e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA18269.1 - 1.6e-11 44.5 0.5 3.1e-11 43.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 ESA18269.1 - 1.9e-09 37.1 0.0 3.1e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.9 ESA18269.1 - 7.1e-06 25.3 0.0 1.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.1 ESA18269.1 - 1.3e-05 25.4 0.0 2.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.10 ESA18269.1 - 2.3e-05 23.6 0.0 4.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Ubie_methyltran PF01209.13 ESA18269.1 - 0.00042 19.5 0.0 0.00061 18.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family tRNA_U5-meth_tr PF05958.6 ESA18269.1 - 0.00044 19.0 0.1 0.00057 18.6 0.1 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_4 PF02390.12 ESA18269.1 - 0.0005 19.1 0.0 0.00086 18.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase DUF938 PF06080.7 ESA18269.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_32 PF13679.1 ESA18269.1 - 0.036 13.7 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 ESA18269.1 - 0.044 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW RrnaAD PF00398.15 ESA18269.1 - 0.059 12.3 0.0 0.092 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FmrO PF07091.6 ESA18269.1 - 0.081 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) FtsJ PF01728.14 ESA18269.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA18269.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Bromodomain PF00439.20 ESA18272.1 - 2.1e-16 59.5 0.3 2.3e-16 59.5 0.2 1.0 1 0 0 1 1 1 1 Bromodomain Amdo_NSP PF12475.3 ESA18272.1 - 0.12 12.3 0.1 0.29 11.0 0.1 1.6 1 1 1 2 2 2 0 Amdovirus non-structural protein CNH PF00780.17 ESA18273.1 - 4.9e-13 49.1 2.1 8.7e-06 25.3 0.1 3.1 3 0 0 3 3 3 3 CNH domain DZR PF12773.2 ESA18273.1 - 0.054 13.3 0.8 0.11 12.3 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon DUF3533 PF12051.3 ESA18273.1 - 0.06 12.0 0.1 0.1 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) zf-C4pol PF14260.1 ESA18273.1 - 0.21 11.6 1.9 0.46 10.5 1.3 1.5 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta PIG-P PF08510.7 ESA18275.1 - 0.00033 20.2 1.4 0.00033 20.2 1.0 1.7 2 0 0 2 2 2 1 PIG-P Tmemb_185A PF10269.4 ESA18275.1 - 0.03 13.9 0.4 0.03 13.9 0.3 2.1 1 1 1 2 2 2 0 Transmembrane Fragile-X-F protein Sensor PF13796.1 ESA18275.1 - 0.07 12.7 1.2 4.1 6.9 0.3 2.1 2 0 0 2 2 2 0 Putative sensor P5-ATPase PF12409.3 ESA18275.1 - 0.14 11.9 0.1 0.14 11.9 0.1 2.2 2 0 0 2 2 2 0 P5-type ATPase cation transporter NfeD PF01957.13 ESA18275.1 - 0.25 11.4 6.4 0.29 11.2 0.0 2.5 1 1 2 3 3 3 0 NfeD-like C-terminal, partner-binding L_HGMIC_fpl PF10242.4 ESA18275.1 - 0.66 9.9 6.2 0.97 9.4 4.0 1.5 1 1 1 2 2 2 0 Lipoma HMGIC fusion partner-like protein Chromo_shadow PF01393.14 ESA18276.1 - 2.9e-14 52.6 0.1 8.3e-12 44.7 0.0 2.6 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.19 ESA18276.1 - 1.5e-11 43.7 3.4 1.5e-11 43.7 2.3 2.4 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Marek_A PF02124.10 ESA18276.1 - 0.081 12.3 0.2 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 Marek's disease glycoprotein A Topoisom_I_N PF02919.10 ESA18277.1 - 1.8e-98 328.1 6.8 1.8e-98 328.1 4.7 4.2 3 2 1 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 ESA18277.1 - 2.7e-88 295.0 12.6 2.7e-88 295.0 8.8 3.2 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 ESA18277.1 - 7.2e-32 108.8 2.3 7.2e-32 108.8 1.6 3.1 3 0 0 3 3 3 1 C-terminal topoisomerase domain Lectin_N PF03954.9 ESA18277.1 - 0.06 12.7 0.1 0.06 12.7 0.0 2.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF1947 PF09183.5 ESA18277.1 - 0.077 12.7 0.1 0.077 12.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) CDC27 PF09507.5 ESA18278.1 - 0.69 9.0 23.9 1 8.4 16.6 1.3 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 SYS1 PF09801.4 ESA18280.1 - 0.011 15.6 3.2 0.062 13.2 0.3 2.3 2 0 0 2 2 2 0 Integral membrane protein S linking to the trans Golgi network Prok-RING_1 PF14446.1 ESA18281.1 - 0.034 13.8 0.4 0.051 13.3 0.3 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 eIF-5_eIF-2B PF01873.12 ESA18281.1 - 0.11 12.1 1.5 0.29 10.7 0.8 1.9 1 1 1 2 2 2 0 Domain found in IF2B/IF5 Sel1 PF08238.7 ESA18282.1 - 7e-22 77.3 6.1 4.1e-13 49.5 0.8 3.2 4 0 0 4 4 4 2 Sel1 repeat TPR_6 PF13174.1 ESA18282.1 - 0.046 14.1 0.7 0.38 11.3 0.2 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18282.1 - 0.12 13.1 0.0 0.18 12.5 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA18282.1 - 0.14 11.7 5.2 2.7 7.7 0.6 2.6 1 1 2 3 3 3 0 TPR repeat TPR_2 PF07719.12 ESA18282.1 - 0.15 12.0 3.2 5.3 7.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA18282.1 - 0.21 11.2 7.7 3.8 7.2 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA18282.1 - 7.4 6.6 7.6 13 5.8 0.9 3.7 2 2 0 2 2 2 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA18283.1 - 5.2e-30 104.3 0.3 9.1e-30 103.5 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18283.1 - 2.1e-26 92.6 0.3 4.4e-26 91.5 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Hint PF01079.15 ESA18283.1 - 0.0012 18.0 0.0 0.0027 16.9 0.0 1.5 1 0 0 1 1 1 1 Hint module ArgJ PF01960.13 ESA18283.1 - 0.0023 16.4 0.3 0.0035 15.7 0.2 1.2 1 0 0 1 1 1 1 ArgJ family Phage_CP76 PF06892.6 ESA18283.1 - 0.053 12.8 0.1 0.099 11.9 0.0 1.4 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) Sel1 PF08238.7 ESA18283.1 - 0.15 12.7 0.7 13 6.6 0.0 3.1 3 0 0 3 3 3 0 Sel1 repeat DUF4200 PF13863.1 ESA18283.1 - 0.83 9.6 8.7 1.6 8.6 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) F-box-like PF12937.2 ESA18284.1 - 2.7e-05 23.8 0.3 7.8e-05 22.3 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF632 PF04782.7 ESA18287.1 - 9.1e-05 21.6 4.0 0.00018 20.7 2.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF632) IncA PF04156.9 ESA18287.1 - 0.00095 18.8 1.5 0.0016 18.0 1.0 1.3 1 0 0 1 1 1 1 IncA protein TMF_DNA_bd PF12329.3 ESA18287.1 - 0.38 10.5 7.1 6.6 6.6 1.1 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF632 PF04782.7 ESA18289.1 - 0.00018 20.7 5.1 0.00033 19.8 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF632) IncA PF04156.9 ESA18289.1 - 0.001 18.7 3.1 0.0017 18.0 2.2 1.3 1 0 0 1 1 1 1 IncA protein ADIP PF11559.3 ESA18289.1 - 0.0025 17.7 9.4 0.0084 16.0 6.5 1.8 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding HAUS-augmin3 PF14932.1 ESA18289.1 - 0.012 14.8 9.4 0.037 13.2 6.5 1.8 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 FlxA PF14282.1 ESA18289.1 - 0.013 15.3 9.5 0.013 15.3 6.6 2.5 2 0 0 2 2 2 0 FlxA-like protein Reo_sigmaC PF04582.7 ESA18289.1 - 0.023 13.9 1.0 0.038 13.1 0.7 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Laminin_I PF06008.9 ESA18289.1 - 0.065 12.5 7.0 0.14 11.4 4.7 1.5 1 1 0 1 1 1 0 Laminin Domain I TMF_DNA_bd PF12329.3 ESA18289.1 - 0.078 12.7 9.4 1.4 8.7 2.2 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Di19_C PF14571.1 ESA18293.1 - 0.065 13.5 1.2 0.1 12.9 0.8 1.2 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal MAT1 PF06391.8 ESA18293.1 - 0.15 11.5 4.0 0.16 11.5 2.8 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Pkinase_Tyr PF07714.12 ESA18294.1 - 0.058 12.4 0.0 0.068 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA18295.1 - 6.9e-27 94.1 0.2 1.8e-26 92.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18295.1 - 9.6e-24 83.9 0.8 9.6e-24 83.9 0.6 1.9 2 0 0 2 2 2 1 Protein kinase domain COP23 PF14218.1 ESA18295.1 - 0.025 14.1 0.1 0.51 9.8 0.1 2.2 2 0 0 2 2 2 0 Circadian oscillating protein COP23 DUF4134 PF13572.1 ESA18295.1 - 0.045 13.8 0.1 0.72 10.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) Fer4_9 PF13187.1 ESA18295.1 - 0.27 11.5 6.5 8.4 6.7 1.5 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Arf PF00025.16 ESA18297.1 - 5.2e-68 227.7 2.8 6.1e-68 227.4 2.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESA18297.1 - 8.4e-13 47.9 0.3 1.1e-12 47.5 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 ESA18297.1 - 4.7e-11 42.3 0.2 5.2e-11 42.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA18297.1 - 1.7e-10 41.3 0.3 2.2e-10 41.0 0.2 1.1 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 ESA18297.1 - 5.3e-08 32.2 0.2 6.1e-08 32.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 ESA18297.1 - 1.1e-07 30.9 1.4 0.0001 21.1 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.18 ESA18297.1 - 7.9e-07 29.0 0.2 1e-06 28.6 0.2 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA18297.1 - 5.4e-05 22.7 0.4 0.0036 16.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 ESA18297.1 - 0.019 14.2 1.4 0.11 11.7 1.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.1 ESA18297.1 - 0.052 13.4 0.3 0.091 12.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA18297.1 - 0.065 13.5 1.4 0.15 12.3 1.0 1.5 1 1 0 1 1 1 0 ABC transporter DUF3067 PF11267.3 ESA18297.1 - 0.066 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3067) 6PF2K PF01591.13 ESA18297.1 - 0.072 12.1 0.3 0.22 10.5 0.0 1.9 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_33 PF13671.1 ESA18297.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 ESA18297.1 - 0.1 12.4 0.5 0.52 10.1 0.0 1.9 1 1 0 2 2 2 0 Dynamin family Ribosomal_L10 PF00466.15 ESA18298.1 - 1.7e-26 92.0 1.1 3.3e-26 91.1 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 ESA18298.1 - 1.4e-19 70.3 5.2 1.4e-19 70.3 3.6 1.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein DUF1021 PF06257.6 ESA18298.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1021) Proteasome PF00227.21 ESA18299.1 - 5.5e-62 208.4 0.3 6.7e-62 208.1 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA18299.1 - 5.2e-14 51.2 0.2 1.1e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Filament PF00038.16 ESA18299.1 - 0.028 13.9 0.5 0.042 13.3 0.3 1.2 1 0 0 1 1 1 0 Intermediate filament protein Imm1 PF14430.1 ESA18299.1 - 0.14 12.2 0.4 22 5.1 0.0 2.9 2 1 0 3 3 3 0 Immunity protein Imm1 Pkinase PF00069.20 ESA18300.1 - 3.5e-74 249.2 0.0 4.5e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18300.1 - 5.5e-34 117.4 0.0 9.1e-34 116.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18300.1 - 0.0069 16.1 0.1 0.031 13.9 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA18300.1 - 0.0088 15.1 0.2 0.023 13.7 0.2 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA18300.1 - 0.023 13.6 0.0 0.46 9.3 0.0 2.3 1 1 1 2 2 2 0 Kinase-like DUF1647 PF07801.6 ESA18301.1 - 0.00034 20.1 0.2 0.00077 18.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) FimH_man-bind PF09160.5 ESA18301.1 - 0.002 17.9 0.1 0.0035 17.1 0.1 1.3 1 0 0 1 1 1 1 FimH, mannose binding tRNA_int_endo PF01974.12 ESA18302.1 - 8.3e-24 83.2 0.3 8.3e-24 83.2 0.2 1.9 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 ESA18302.1 - 0.00021 20.7 0.8 0.0019 17.7 0.3 2.4 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain NAM-associated PF14303.1 ESA18302.1 - 0.02 15.2 8.9 0.029 14.6 6.2 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain HHH_3 PF12836.2 ESA18302.1 - 0.023 14.6 1.5 0.046 13.6 1.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif His_Phos_2 PF00328.17 ESA18302.1 - 0.039 13.3 0.1 0.044 13.1 0.1 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Nop25 PF09805.4 ESA18302.1 - 0.79 9.7 15.4 1.2 9.2 10.6 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Ribosomal_L37 PF08561.5 ESA18302.1 - 4.1 7.0 8.2 0.55 9.8 2.3 1.9 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L37 Lipase_3 PF01764.20 ESA18303.1 - 2.7e-07 30.2 0.0 7.2e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA18303.1 - 0.0063 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 ESA18303.1 - 0.079 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Nop14 PF04147.7 ESA18304.1 - 2.4e-95 320.2 7.9 2.7e-95 320.0 5.5 1.0 1 0 0 1 1 1 1 Nop14-like family Myb_DNA-bind_4 PF13837.1 ESA18304.1 - 0.02 15.0 2.3 9.2 6.4 0.0 2.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Peptidase_C11 PF03415.9 ESA18304.1 - 0.11 11.4 2.1 0.15 11.0 1.5 1.1 1 0 0 1 1 1 0 Clostripain family Pkinase PF00069.20 ESA18305.1 - 6.4e-37 127.1 0.0 8.2e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18305.1 - 9.5e-37 126.4 0.0 1.1e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18305.1 - 0.00046 19.9 0.0 0.00069 19.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA18305.1 - 0.045 12.8 0.0 0.065 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA18305.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family F-box-like PF12937.2 ESA18307.1 - 6.6e-07 28.9 0.1 6.6e-07 28.9 0.1 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA18307.1 - 7.5e-07 28.6 0.2 1.5e-06 27.6 0.2 1.6 1 0 0 1 1 1 1 F-box domain Methyltransf_16 PF10294.4 ESA18308.1 - 3.4e-18 65.6 0.1 4.8e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 ESA18308.1 - 0.00033 20.4 0.0 0.0005 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18308.1 - 0.00096 19.7 0.0 0.002 18.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 ESA18308.1 - 0.0096 14.9 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family PrmA PF06325.8 ESA18308.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Zn_Tnp_IS91 PF14319.1 ESA18309.1 - 0.011 15.2 4.0 0.012 15.0 2.8 1.0 1 0 0 1 1 1 0 Transposase zinc-binding domain APH PF01636.18 ESA18310.1 - 5.3e-06 26.3 0.0 0.002 17.9 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family DUF4014 PF13198.1 ESA18311.1 - 0.82 10.1 5.0 52 4.3 3.5 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4014) MCRS_N PF13325.1 ESA18312.1 - 0.076 12.5 0.1 0.08 12.4 0.1 1.1 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein zf-BED PF02892.10 ESA18313.1 - 0.0022 17.7 8.5 0.0038 16.9 5.9 1.4 1 0 0 1 1 1 1 BED zinc finger MULE PF10551.4 ESA18314.1 - 0.011 15.9 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 MULE transposase domain DUF4564 PF15169.1 ESA18314.1 - 0.025 14.3 0.3 1 9.0 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4564) Flu_NS2 PF00601.14 ESA18314.1 - 0.085 13.0 0.3 3.4 7.9 0.1 2.4 1 1 1 2 2 2 0 Influenza non-structural protein (NS2) Borrelia_orfD PF02999.9 ESA18315.1 - 0.037 14.1 2.6 1.3 9.2 0.2 2.2 2 0 0 2 2 2 0 Borrelia orf-D family GATA PF00320.22 ESA18316.1 - 1.6e-18 65.7 4.0 2.2e-18 65.2 2.8 1.2 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 ESA18316.1 - 0.0013 18.0 2.3 0.0072 15.6 2.0 1.8 1 1 1 2 2 2 2 TFIIB zinc-binding RRN7 PF11781.3 ESA18316.1 - 0.0033 16.8 0.6 0.0052 16.2 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 DZR PF12773.2 ESA18316.1 - 0.011 15.5 1.2 0.022 14.5 0.8 1.5 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 ESA18316.1 - 0.034 13.6 1.2 0.86 9.1 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 ESA18316.1 - 0.035 13.9 0.2 0.056 13.2 0.2 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Elf1 PF05129.8 ESA18316.1 - 0.047 13.3 0.1 0.065 12.9 0.1 1.3 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-FCS PF06467.9 ESA18316.1 - 0.059 13.0 0.3 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-Sec23_Sec24 PF04810.10 ESA18316.1 - 0.075 12.6 0.2 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.5 ESA18316.1 - 0.083 12.8 0.7 0.17 11.8 0.4 1.6 1 1 0 1 1 1 0 Zinc ribbon domain DUF2387 PF09526.5 ESA18316.1 - 0.087 12.7 0.2 0.13 12.2 0.1 1.3 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) OrfB_Zn_ribbon PF07282.6 ESA18316.1 - 0.098 12.3 0.4 0.14 11.7 0.3 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-B_box PF00643.19 ESA18316.1 - 0.11 12.4 0.9 6.1 6.8 0.1 2.2 2 0 0 2 2 2 0 B-box zinc finger Auto_anti-p27 PF06677.7 ESA18316.1 - 0.13 12.0 0.5 0.26 11.0 0.4 1.6 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.12 ESA18316.1 - 0.14 11.8 0.4 0.2 11.2 0.3 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 zf-ribbon_3 PF13248.1 ESA18316.1 - 0.3 10.3 4.8 0.57 9.4 0.4 1.9 1 1 1 2 2 2 0 zinc-ribbon domain GEMIN8 PF15348.1 ESA18317.1 - 9.6e-06 25.7 18.6 8.1e-05 22.7 12.9 2.4 1 1 0 1 1 1 1 Gemini of Cajal bodies-associated protein 8 DUF3807 PF12720.2 ESA18317.1 - 0.00014 22.0 5.4 0.00019 21.6 3.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) Rho_N PF07498.7 ESA18317.1 - 0.073 12.8 0.8 0.14 11.9 0.6 1.5 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain Lipoprotein_18 PF06804.6 ESA18317.1 - 0.45 9.2 5.1 0.61 8.7 3.5 1.1 1 0 0 1 1 1 0 NlpB/DapX lipoprotein Methyltransf_6 PF03737.10 ESA18318.1 - 3.6e-28 98.3 0.0 8.2e-28 97.2 0.0 1.5 2 0 0 2 2 2 1 Demethylmenaquinone methyltransferase VCBS PF13517.1 ESA18319.1 - 8.9e-28 96.4 12.6 7.7e-08 32.5 0.1 5.3 3 3 2 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 ESA18319.1 - 3.5e-15 55.1 19.9 0.0013 18.3 0.0 7.3 7 0 0 7 7 7 5 FG-GAP repeat TcdB_toxin_midN PF12256.3 ESA18319.1 - 2.7e-06 26.9 5.2 0.094 12.1 0.1 5.4 5 1 1 6 6 6 2 Insecticide toxin TcdB middle/N-terminal region Vpu PF00558.14 ESA18319.1 - 0.019 14.5 1.2 0.038 13.5 0.8 1.4 1 0 0 1 1 1 0 Vpu protein 2TM PF13239.1 ESA18319.1 - 0.12 12.4 0.1 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 2TM domain DUF2127 PF09900.4 ESA18319.1 - 3.9 7.5 6.0 0.29 11.1 0.2 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) Glycophorin_A PF01102.13 ESA18320.1 - 0.24 11.1 7.6 0.13 12.0 3.8 1.6 2 0 0 2 2 2 0 Glycophorin A Dicty_REP PF05086.7 ESA18320.1 - 0.29 8.8 3.3 0.3 8.7 2.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3534 PF12053.3 ESA18320.1 - 0.32 10.8 2.5 0.47 10.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3534) Mucin PF01456.12 ESA18320.1 - 0.44 10.3 22.3 0.72 9.6 15.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Sec7 PF01369.15 ESA18321.1 - 3.2e-40 137.8 1.7 4.6e-40 137.3 1.2 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 ESA18321.1 - 2.3e-16 60.0 0.0 4.4e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 ESA18321.1 - 7e-12 45.4 0.1 2.1e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_4 PF15404.1 ESA18321.1 - 0.034 13.6 0.1 23 4.4 0.0 3.7 3 1 1 4 4 4 0 Pleckstrin homology domain PH_6 PF15406.1 ESA18321.1 - 0.045 13.8 0.0 0.09 12.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.1 ESA18321.1 - 0.063 13.5 1.2 0.89 9.8 0.4 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain GATA PF00320.22 ESA18322.1 - 5.4e-29 99.2 16.3 7.2e-16 57.2 1.2 2.1 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.7 ESA18322.1 - 2e-06 26.9 8.5 0.0086 15.3 1.9 2.7 2 1 1 3 3 3 3 TFIIB zinc-binding DZR PF12773.2 ESA18322.1 - 3.2e-05 23.6 4.1 0.00045 19.9 2.8 2.4 1 1 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.5 ESA18322.1 - 0.00041 20.2 3.0 0.2 11.6 0.4 2.5 2 0 0 2 2 2 2 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 ESA18322.1 - 0.00081 19.1 3.7 0.066 13.0 0.1 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain RRN7 PF11781.3 ESA18322.1 - 0.0018 17.7 4.1 0.0053 16.2 0.3 2.5 2 1 0 2 2 2 1 RNA polymerase I-specific transcription initiation factor Rrn7 OrfB_Zn_ribbon PF07282.6 ESA18322.1 - 0.023 14.3 5.4 0.79 9.4 0.5 2.2 2 0 0 2 2 2 0 Putative transposase DNA-binding domain eIF-5_eIF-2B PF01873.12 ESA18322.1 - 0.027 14.1 4.8 0.52 9.9 0.5 2.1 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Auto_anti-p27 PF06677.7 ESA18322.1 - 0.033 13.9 3.4 0.3 10.8 0.4 2.7 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2318 PF10080.4 ESA18322.1 - 0.045 13.5 1.7 2.6 7.8 0.0 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) zf-CHY PF05495.7 ESA18322.1 - 0.14 12.3 2.4 1.5 9.0 1.7 2.1 1 1 0 1 1 1 0 CHY zinc finger zf-Sec23_Sec24 PF04810.10 ESA18322.1 - 0.23 11.0 0.3 0.23 11.0 0.2 2.3 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger GSu_C4xC__C2xCH PF09698.5 ESA18322.1 - 0.3 11.2 10.7 1.3 9.2 0.4 2.7 2 1 1 3 3 3 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) DUF2387 PF09526.5 ESA18322.1 - 0.34 10.8 2.3 12 5.9 0.5 2.3 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) NMD3 PF04981.8 ESA18322.1 - 0.38 9.8 3.1 5.9 5.9 2.1 2.0 1 1 0 1 1 1 0 NMD3 family zinc_ribbon_2 PF13240.1 ESA18322.1 - 0.42 10.1 11.3 0.94 9.0 0.0 3.9 4 0 0 4 4 4 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 ESA18322.1 - 0.48 9.6 13.6 0.61 9.3 0.3 3.8 3 1 1 4 4 4 0 zinc-ribbon domain LIM PF00412.17 ESA18322.1 - 0.53 10.3 4.1 6.9 6.8 0.3 2.3 2 0 0 2 2 2 0 LIM domain HNH PF01844.18 ESA18322.1 - 0.81 9.6 3.5 1.7 8.5 0.6 2.5 2 1 0 2 2 2 0 HNH endonuclease zf-B_box PF00643.19 ESA18322.1 - 1.2 9.1 7.9 18 5.3 0.0 3.6 4 0 0 4 4 4 0 B-box zinc finger FYVE PF01363.16 ESA18322.1 - 1.3 8.9 4.4 7.2 6.5 3.0 2.2 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_3 PF14369.1 ESA18322.1 - 2 8.5 8.3 13 5.8 0.2 3.1 2 1 1 3 3 3 0 zinc-finger A2L_zn_ribbon PF08792.5 ESA18322.1 - 3.4 7.2 8.7 14 5.3 0.1 3.6 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-NADH-PPase PF09297.6 ESA18322.1 - 5.5 6.5 7.5 2.7 7.5 0.1 3.1 4 0 0 4 4 3 0 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.1 ESA18322.1 - 8.8 6.1 10.2 6.9 6.4 0.2 3.6 3 1 1 4 4 4 0 Nudix N-terminal DNA_RNApol_7kD PF03604.8 ESA18322.1 - 9.4 5.8 8.9 15 5.1 0.2 3.5 2 2 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit 2-Hacid_dh PF00389.25 ESA18323.1 - 1.9e-25 88.8 0.0 2e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.14 ESA18323.1 - 2.5e-20 72.3 0.0 3.5e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESA18323.1 - 0.039 13.3 0.0 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 ESA18323.1 - 0.13 12.6 0.2 0.35 11.3 0.1 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Metallophos PF00149.23 ESA18324.1 - 8.1e-39 133.0 0.2 1.3e-38 132.4 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.7 ESA18324.1 - 1e-33 115.1 1.7 1e-33 115.1 1.2 2.4 3 0 0 3 3 3 1 PPP5 TPR repeat region TPR_11 PF13414.1 ESA18324.1 - 7.7e-17 60.7 6.5 1.4e-16 59.8 4.0 1.8 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 ESA18324.1 - 3.2e-07 29.6 6.7 0.0029 17.1 0.6 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA18324.1 - 4.1e-07 29.4 7.8 0.0028 17.4 0.6 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18324.1 - 0.0031 18.1 1.6 0.0064 17.1 1.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18324.1 - 0.0083 16.2 2.1 1.1 9.6 0.8 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat HapK PF11639.3 ESA18324.1 - 0.077 13.6 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 REDY-like protein HapK U1snRNP70_N PF12220.3 ESA18325.1 - 2.7e-30 104.5 3.5 4.8e-30 103.7 2.4 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 ESA18325.1 - 6.9e-19 67.2 0.0 1.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18325.1 - 1.2e-17 63.6 0.0 1.9e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18325.1 - 8.8e-13 47.9 0.0 1.4e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NusG PF02357.14 ESA18325.1 - 0.0073 16.5 1.0 4.1 7.7 0.0 2.5 2 0 0 2 2 2 2 Transcription termination factor nusG Methyltransf_PK PF05891.7 ESA18325.1 - 0.07 12.4 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase PRE_C2HC PF07530.6 ESA18325.1 - 0.13 12.1 0.8 0.41 10.5 0.0 2.1 2 1 0 2 2 2 0 Associated with zinc fingers 2-Hacid_dh PF00389.25 ESA18327.1 - 1.5e-26 92.4 0.0 1.6e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.14 ESA18327.1 - 3e-20 72.1 0.0 4.3e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 ESA18327.1 - 0.054 12.8 0.0 0.2 11.0 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF2357 PF09823.4 ESA18330.1 - 0.072 12.1 0.0 0.085 11.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) Topoisom_bac PF01131.15 ESA18331.1 - 0.066 12.0 0.0 0.079 11.7 0.0 1.0 1 0 0 1 1 1 0 DNA topoisomerase KaiC PF06745.8 ESA18333.1 - 0.0049 16.0 0.2 0.11 11.5 0.0 2.0 1 1 1 2 2 2 2 KaiC IstB_IS21 PF01695.12 ESA18333.1 - 0.0062 15.9 0.0 0.0067 15.8 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF87 PF01935.12 ESA18333.1 - 0.0072 16.1 0.0 0.0078 16.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_18 PF13238.1 ESA18333.1 - 0.011 16.0 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 ESA18333.1 - 0.12 11.3 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.1 ESA18333.1 - 0.14 11.4 0.0 0.17 11.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain DDE_1 PF03184.14 ESA18334.1 - 3.5e-13 49.1 0.2 1.8e-05 23.9 0.1 2.5 2 0 0 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA18334.1 - 9.6e-06 25.3 0.0 2.2e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain PMM PF03332.8 ESA18337.1 - 0.087 12.3 0.1 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic phosphomannomutase WLM PF08325.5 ESA18338.1 - 0.049 13.5 0.7 0.049 13.5 0.5 1.1 1 0 0 1 1 1 0 WLM domain AAA_35 PF14516.1 ESA18341.1 - 8.2e-05 21.3 0.0 0.00015 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain DUF1706 PF08020.6 ESA18341.1 - 0.08 12.4 1.1 2.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1706) BTB PF00651.26 ESA18343.1 - 2.1e-16 59.8 1.6 5.3e-16 58.5 1.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA18343.1 - 1.2e-11 44.7 0.7 1.2e-11 44.7 0.5 3.3 2 1 1 3 3 3 1 TLD BACK PF07707.10 ESA18343.1 - 1.4e-06 28.0 5.6 0.00022 21.0 0.7 3.5 1 1 2 3 3 3 2 BTB And C-terminal Kelch DUF4130 PF13566.1 ESA18343.1 - 0.067 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 Alpha_kinase PF02816.13 ESA18344.1 - 7.3e-35 120.3 0.3 1.7e-34 119.1 0.2 1.6 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA18344.1 - 4.2e-08 33.4 0.0 6.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA18344.1 - 0.0027 17.4 0.0 0.0059 16.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Laminin_I PF06008.9 ESA18344.1 - 1.4 8.2 6.3 8.6 5.5 1.9 3.1 4 0 0 4 4 4 0 Laminin Domain I BTB PF00651.26 ESA18345.1 - 6.1e-20 71.2 0.2 1.2e-19 70.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA18345.1 - 1.4e-05 24.8 1.3 0.00036 20.3 0.1 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA18345.1 - 0.0032 16.6 0.0 0.0047 16.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) GatB_Yqey PF02637.13 ESA18345.1 - 0.093 12.4 0.4 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 GatB domain LSM PF01423.17 ESA18347.1 - 7.6e-18 63.8 0.0 9.7e-18 63.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain RNB PF00773.14 ESA18348.1 - 5.6e-71 239.4 0.0 5.6e-71 239.4 0.0 1.6 2 0 0 2 2 2 1 RNB domain zf-RING_2 PF13639.1 ESA18349.1 - 2.3e-15 56.1 5.0 2.3e-15 56.1 3.5 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_3 PF14369.1 ESA18349.1 - 6.1e-13 48.5 1.8 6.1e-13 48.5 1.3 2.9 3 0 0 3 3 3 1 zinc-finger zf-C3HC4_3 PF13920.1 ESA18349.1 - 1.8e-10 40.3 9.4 1.1e-08 34.5 1.4 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA18349.1 - 1.3e-09 38.0 2.2 1.3e-09 38.0 1.5 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA18349.1 - 4.3e-09 36.2 6.1 4.3e-09 36.2 4.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA18349.1 - 7.3e-08 31.9 5.9 7.3e-08 31.9 4.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA18349.1 - 2.3e-07 30.4 1.1 1.3e-06 28.0 0.2 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA18349.1 - 3.5e-07 29.8 12.3 3.8e-07 29.7 2.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 ESA18349.1 - 8e-05 22.4 3.2 8e-05 22.4 2.2 2.0 2 1 1 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger HypA PF01155.14 ESA18349.1 - 0.0039 16.8 4.9 0.42 10.3 0.1 2.3 2 0 0 2 2 2 2 Hydrogenase expression/synthesis hypA family DUF1272 PF06906.6 ESA18349.1 - 0.0041 16.9 8.2 0.51 10.2 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1272) zf-TFIIB PF13453.1 ESA18349.1 - 0.025 13.7 7.1 20 4.4 0.0 4.2 4 0 0 4 4 4 0 Transcription factor zinc-finger zf-C3HC4_4 PF15227.1 ESA18349.1 - 0.029 14.2 6.8 0.029 14.2 4.7 2.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Vps39_2 PF10367.4 ESA18349.1 - 0.14 12.3 0.1 0.14 12.3 0.1 2.3 3 0 0 3 3 2 0 Vacuolar sorting protein 39 domain 2 DZR PF12773.2 ESA18349.1 - 0.22 11.3 9.7 0.32 10.8 0.7 3.0 2 1 0 2 2 2 0 Double zinc ribbon zf-Di19 PF05605.7 ESA18349.1 - 0.46 10.6 6.3 35 4.6 0.2 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_4 PF14570.1 ESA18349.1 - 0.65 9.6 14.9 0.13 11.9 4.2 2.9 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.9 ESA18349.1 - 0.72 9.3 6.6 5.8 6.4 0.1 2.7 3 0 0 3 3 2 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.5 ESA18349.1 - 1.1 9.2 8.7 0.23 11.4 1.0 3.0 3 0 0 3 3 3 0 Zinc ribbon domain RINGv PF12906.2 ESA18349.1 - 2 8.5 6.6 0.97 9.5 2.6 1.9 2 0 0 2 2 1 0 RING-variant domain DUF2225 PF09986.4 ESA18349.1 - 2.3 7.6 8.2 0.44 9.9 2.6 2.1 2 1 0 2 2 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Prok-RING_1 PF14446.1 ESA18349.1 - 2.5 7.9 12.6 0.56 9.9 3.4 3.1 2 2 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C4_Topoisom PF01396.14 ESA18349.1 - 3.1 7.3 6.2 20 4.7 0.1 3.1 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Thioredoxin_4 PF13462.1 ESA18349.1 - 6 6.8 6.6 11 5.9 0.3 3.5 3 1 1 4 4 4 0 Thioredoxin Aminotran_1_2 PF00155.16 ESA18350.1 - 3.8e-65 220.2 0.0 4.3e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 ESA18350.1 - 4.9e-05 22.2 0.0 8.2e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESA18350.1 - 0.00055 19.1 0.0 0.00083 18.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 ESA18350.1 - 0.0048 15.2 0.0 0.0081 14.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme zf-Tim10_DDP PF02953.10 ESA18351.1 - 3.4e-21 74.2 0.7 4.3e-21 73.9 0.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger KOW PF00467.24 ESA18352.1 - 2.1e-05 24.0 0.3 7.1e-05 22.3 0.2 1.9 1 0 0 1 1 1 1 KOW motif HAD PF12710.2 ESA18353.1 - 2.2e-12 47.5 0.4 3.3e-12 46.9 0.3 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase EMP24_GP25L PF01105.19 ESA18354.1 - 2e-46 158.0 0.1 2.4e-46 157.7 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF846 PF05832.7 ESA18354.1 - 0.38 10.4 3.1 0.13 11.9 0.3 1.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF846) AAA PF00004.24 ESA18355.1 - 2.9e-05 24.2 0.0 3.3e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NUDIX PF00293.23 ESA18357.1 - 0.00024 20.7 0.0 0.00039 20.0 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain AAA PF00004.24 ESA18358.1 - 2.4e-41 141.0 0.0 5.4e-41 139.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA18358.1 - 2.1e-05 24.2 0.1 0.00012 21.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA18358.1 - 3.4e-05 23.8 0.1 0.0031 17.5 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 ESA18358.1 - 0.00011 21.3 0.0 0.00026 20.1 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ESA18358.1 - 0.00025 20.9 0.0 0.0016 18.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESA18358.1 - 0.00036 20.6 0.5 0.012 15.7 0.3 2.5 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 ESA18358.1 - 0.00084 18.6 0.6 0.013 14.7 0.0 2.5 3 0 0 3 3 3 1 PhoH-like protein DUF815 PF05673.8 ESA18358.1 - 0.002 17.0 0.0 0.002 17.0 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 ESA18358.1 - 0.004 16.3 0.1 0.012 14.7 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 ESA18358.1 - 0.004 17.0 0.1 0.011 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESA18358.1 - 0.0049 17.6 1.1 0.033 15.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA18358.1 - 0.0054 16.4 0.2 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 ESA18358.1 - 0.0074 15.7 0.1 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 ESA18358.1 - 0.0089 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain DeoC PF01791.4 ESA18358.1 - 0.019 14.2 0.6 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 DeoC/LacD family aldolase Zeta_toxin PF06414.7 ESA18358.1 - 0.027 13.5 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 ESA18358.1 - 0.032 13.6 0.9 0.42 10.0 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_11 PF13086.1 ESA18358.1 - 0.043 13.3 0.1 0.69 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 ESA18358.1 - 0.048 13.3 0.3 0.96 9.0 0.0 2.2 1 1 1 2 2 2 0 NACHT domain RNA_helicase PF00910.17 ESA18358.1 - 0.071 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase KaiC PF06745.8 ESA18358.1 - 0.085 11.9 1.0 0.2 10.7 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.1 ESA18358.1 - 0.087 12.3 1.8 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 ESA18358.1 - 0.088 12.2 0.0 0.28 10.6 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain Sas10_Utp3 PF04000.10 ESA18359.1 - 2.9e-06 27.3 0.1 4.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Pkinase_Tyr PF07714.12 ESA18360.1 - 4.2e-50 170.2 0.0 7.3e-50 169.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18360.1 - 1.5e-46 158.6 0.1 2.9e-46 157.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA18360.1 - 8.3e-31 105.7 10.4 3.7e-09 36.9 0.0 4.7 4 0 0 4 4 4 4 Sel1 repeat WaaY PF06176.6 ESA18360.1 - 1.7e-07 30.7 0.6 4e-07 29.5 0.4 1.6 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA18360.1 - 0.0041 16.2 0.0 0.0082 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA18360.1 - 0.0052 16.1 0.2 0.016 14.5 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA18360.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Epimerase PF01370.16 ESA18361.1 - 6.3e-53 179.6 0.0 1e-52 178.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 ESA18361.1 - 4.1e-06 25.9 0.0 0.00025 20.0 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 ESA18361.1 - 7.5e-06 25.0 0.8 0.00013 21.0 0.0 2.7 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 ESA18361.1 - 0.032 12.9 0.3 0.25 10.0 0.2 2.1 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TFIIE_alpha PF02002.12 ESA18362.1 - 2.3e-14 52.7 0.5 4.9e-14 51.7 0.3 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit ADK_lid PF05191.9 ESA18362.1 - 0.0013 18.3 2.7 0.02 14.5 0.7 2.5 2 0 0 2 2 2 1 Adenylate kinase, active site lid DUF2197 PF09963.4 ESA18362.1 - 0.064 13.2 0.2 1.7 8.6 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) F-box-like PF12937.2 ESA18364.1 - 0.022 14.4 0.9 0.022 14.4 0.6 3.1 3 1 0 3 3 3 0 F-box-like PCI PF01399.22 ESA18364.1 - 2.1 8.7 6.1 1.6 9.1 0.6 2.9 2 2 0 2 2 2 0 PCI domain LRR_4 PF12799.2 ESA18364.1 - 3.4 7.3 9.1 15 5.3 0.4 4.5 4 2 0 4 4 4 0 Leucine Rich repeats (2 copies) COMP PF11598.3 ESA18367.1 - 0.17 11.9 0.0 0.17 11.9 0.0 3.2 4 1 0 4 4 4 0 Cartilage oligomeric matrix protein SprA-related PF12118.3 ESA18368.1 - 0.47 9.7 30.1 0.56 9.4 20.9 1.1 1 0 0 1 1 1 0 SprA-related family Nop14 PF04147.7 ESA18368.1 - 1.6 6.5 48.3 2.2 6.1 33.5 1.3 1 0 0 1 1 1 0 Nop14-like family Hid1 PF12722.2 ESA18368.1 - 8.7 3.8 22.1 8.4 3.9 15.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MP PF01107.13 ESA18369.1 - 0.003 16.9 0.1 0.003 16.9 0.1 1.0 1 0 0 1 1 1 1 Viral movement protein (MP) CAT_RBD PF03123.10 ESA18370.1 - 0.047 13.3 2.4 1.3 8.7 0.1 2.3 1 1 1 2 2 2 0 CAT RNA binding domain DUF2808 PF10989.3 ESA18370.1 - 0.13 11.9 0.5 1.1 8.9 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2808) DUF4576 PF15144.1 ESA18371.1 - 0.065 12.8 0.0 0.078 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Colicin_D PF11429.3 ESA18372.1 - 0.033 14.3 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Colicin D DUF2783 PF10932.3 ESA18373.1 - 0.067 12.6 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) Asp_protease_2 PF13650.1 ESA18374.1 - 0.00027 21.3 0.0 0.00046 20.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA18374.1 - 0.0062 16.3 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 ESA18374.1 - 0.011 15.5 0.0 0.41 10.6 0.0 2.4 2 1 0 2 2 2 0 Retroviral aspartyl protease DUF1758 PF05585.7 ESA18374.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Pkinase_Tyr PF07714.12 ESA18375.1 - 9.9e-38 129.6 0.0 1.4e-37 129.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18375.1 - 9.7e-33 113.4 0.0 2.4e-32 112.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Kinase-like PF14531.1 ESA18375.1 - 9.8e-05 21.4 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA18375.1 - 0.0085 15.8 0.1 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Sec7 PF01369.15 ESA18375.1 - 0.033 13.8 3.0 0.15 11.6 0.8 2.2 2 0 0 2 2 2 0 Sec7 domain Kdo PF06293.9 ESA18375.1 - 0.046 12.7 0.0 0.076 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2962 PF11176.3 ESA18375.1 - 0.13 11.8 1.5 0.23 10.9 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2962) Pkinase PF00069.20 ESA18376.1 - 9.7e-24 83.9 0.4 1.2e-23 83.5 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18376.1 - 8e-23 80.8 0.1 1.1e-22 80.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TIP41 PF04176.8 ESA18376.1 - 0.11 11.7 1.2 0.22 10.7 0.8 1.6 1 1 0 1 1 1 0 TIP41-like family ABC1 PF03109.11 ESA18376.1 - 0.13 12.2 0.0 0.45 10.4 0.0 1.8 1 1 1 2 2 2 0 ABC1 family FUSC_2 PF13515.1 ESA18378.1 - 4.5e-19 68.6 23.5 1.8e-18 66.7 6.4 2.6 2 0 0 2 2 2 2 Fusaric acid resistance protein-like FUSC PF04632.7 ESA18378.1 - 5.3e-15 54.9 2.0 8.3e-10 37.7 2.3 2.2 2 0 0 2 2 2 2 Fusaric acid resistance protein family ALMT PF11744.3 ESA18378.1 - 1.5e-12 46.9 14.1 7.8e-12 44.5 0.7 3.1 3 0 0 3 3 3 2 Aluminium activated malate transporter DUF2421 PF10334.4 ESA18378.1 - 4.5e-10 39.5 0.1 1e-09 38.3 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) DCP2 PF05026.8 ESA18378.1 - 0.00074 19.3 1.7 0.0016 18.3 0.1 2.4 2 0 0 2 2 2 1 Dcp2, box A domain DUF2422 PF10337.4 ESA18378.1 - 0.029 13.1 13.6 0.0091 14.8 0.8 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2422) Cation_efflux PF01545.16 ESA18378.1 - 0.24 10.4 8.4 0.11 11.5 0.7 2.3 2 0 0 2 2 2 0 Cation efflux family Mit_KHE1 PF10173.4 ESA18379.1 - 1e-42 146.1 0.6 1.2e-42 145.8 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related F-box-like PF12937.2 ESA18382.1 - 7e-05 22.4 0.2 0.0002 21.0 0.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA18382.1 - 9.3 6.0 42.7 0.27 10.9 2.6 6.7 4 2 3 7 7 7 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA18382.1 - 9.5 6.0 41.5 0.46 10.2 4.1 7.4 6 1 2 8 8 8 0 Leucine rich repeat PAD PF03068.10 ESA18383.1 - 0.11 10.9 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) DUF1163 PF06651.6 ESA18383.1 - 0.33 10.5 1.9 1.5 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) DUF2756 PF10956.3 ESA18385.1 - 0.27 11.4 11.7 0.5 10.6 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) DUF3684 PF12449.3 ESA18386.1 - 1.5e-196 655.3 0.1 6.7e-146 487.6 0.2 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HAUS-augmin3 PF14932.1 ESA18386.1 - 0.045 12.9 0.0 0.093 11.8 0.0 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ATG16 PF08614.6 ESA18388.1 - 0.0014 18.5 0.2 0.0018 18.1 0.2 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Peptidase_M32 PF02074.10 ESA18388.1 - 0.059 11.9 0.0 0.064 11.8 0.0 1.1 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase Med2 PF11214.3 ESA18388.1 - 0.079 13.0 0.8 0.37 10.8 0.6 1.9 1 1 0 1 1 1 0 Mediator complex subunit 2 Cast PF10174.4 ESA18388.1 - 0.087 10.8 1.4 0.11 10.5 1.0 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone TMF_DNA_bd PF12329.3 ESA18388.1 - 0.2 11.4 0.9 0.98 9.2 0.3 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding CD20 PF04103.10 ESA18390.1 - 0.033 14.1 0.6 0.034 14.0 0.4 1.0 1 0 0 1 1 1 0 CD20-like family STE PF02200.11 ESA18391.1 - 0.014 15.5 0.0 0.016 15.3 0.0 1.1 1 0 0 1 1 1 0 STE like transcription factor p450 PF00067.17 ESA18392.1 - 1.7e-19 69.6 0.0 2e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1350 PF07082.6 ESA18392.1 - 0.08 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Pkinase_Tyr PF07714.12 ESA18393.1 - 1.8e-43 148.4 0.0 2.5e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18393.1 - 8.3e-38 130.0 0.0 2.2e-37 128.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain SoxE PF06525.6 ESA18395.1 - 0.025 13.8 2.2 0.038 13.2 1.5 1.3 1 0 0 1 1 1 0 Sulfocyanin (SoxE) FYRC PF05965.9 ESA18396.1 - 0.032 14.0 0.1 0.23 11.2 0.0 2.3 1 1 0 1 1 1 0 F/Y rich C-terminus ResIII PF04851.10 ESA18397.1 - 0.065 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATG16 PF08614.6 ESA18398.1 - 0.0019 18.0 5.7 0.01 15.6 4.0 1.9 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4200 PF13863.1 ESA18398.1 - 0.002 18.0 6.1 0.0033 17.3 4.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) ADIP PF11559.3 ESA18398.1 - 0.017 14.9 0.4 0.017 14.9 0.3 2.5 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Macoilin PF09726.4 ESA18398.1 - 0.023 12.9 3.9 0.028 12.7 2.7 1.0 1 0 0 1 1 1 0 Transmembrane protein Spc7 PF08317.6 ESA18398.1 - 0.084 11.5 5.8 0.11 11.1 4.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.4 ESA18398.1 - 0.15 10.9 4.2 0.19 10.6 2.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TMF_DNA_bd PF12329.3 ESA18398.1 - 0.63 9.8 12.8 0.43 10.4 5.2 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DivIVA PF05103.8 ESA18398.1 - 0.96 9.4 5.9 1.1 9.3 0.1 2.2 1 1 1 2 2 2 0 DivIVA protein zf-C4pol PF14260.1 ESA18398.1 - 1.3 9.0 3.9 5.4 7.0 1.0 2.4 1 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Ricin_B_lectin PF00652.17 ESA18399.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain Sec63 PF02889.11 ESA18400.1 - 5.4e-211 699.2 0.1 1.6e-113 379.1 0.2 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 ESA18400.1 - 1.4e-54 184.1 0.5 5.8e-31 107.2 0.2 3.3 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.10 ESA18400.1 - 1.2e-21 77.3 0.4 3.9e-12 46.3 0.0 3.0 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESA18400.1 - 3e-16 59.0 0.0 1.2e-09 37.9 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESA18400.1 - 4.6e-07 30.0 0.0 0.001 19.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain PhoH PF02562.11 ESA18400.1 - 2.3e-05 23.7 0.0 0.1 11.8 0.0 2.9 3 0 0 3 3 3 2 PhoH-like protein AAA_10 PF12846.2 ESA18400.1 - 0.00022 20.7 0.0 2.5 7.4 0.0 4.2 3 1 1 4 4 4 2 AAA-like domain T2SE PF00437.15 ESA18400.1 - 0.001 18.0 0.0 1 8.2 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_19 PF13245.1 ESA18400.1 - 0.002 17.8 0.0 0.36 10.6 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Cpn60_TCP1 PF00118.19 ESA18401.1 - 4.5e-145 483.9 2.9 5.6e-145 483.6 2.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.27 ESA18402.1 - 2.7e-39 131.6 8.9 1.5e-09 37.3 0.4 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA18402.1 - 0.00014 21.6 0.4 0.041 13.5 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Kelch_6 PF13964.1 ESA18402.1 - 0.0023 18.0 0.1 0.19 11.9 0.0 2.9 3 0 0 3 3 3 1 Kelch motif YmzC PF14157.1 ESA18402.1 - 0.12 12.2 0.1 2.3 8.1 0.0 2.9 3 0 0 3 3 3 0 YmzC-like protein Thioredoxin PF00085.15 ESA18403.1 - 4e-08 32.8 0.0 6.6e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin FAR1 PF03101.10 ESA18404.1 - 1.1e-13 51.4 0.0 2.1e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA18404.1 - 8.4e-05 22.0 0.2 0.037 13.6 0.0 2.5 2 0 0 2 2 2 2 MuDR family transposase AFT PF08731.6 ESA18404.1 - 0.0044 17.1 0.1 0.0071 16.5 0.1 1.6 1 1 0 1 1 1 1 Transcription factor AFT DUF4502 PF14950.1 ESA18404.1 - 0.06 12.5 0.8 0.1 11.7 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4502) dCMP_cyt_deam_1 PF00383.17 ESA18405.1 - 2.9e-19 68.5 1.6 4.2e-19 68.0 1.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region AAA_17 PF13207.1 ESA18405.1 - 0.0056 17.4 0.0 0.013 16.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA18405.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cys_rich_CWC PF14375.1 ESA18405.1 - 7.4 6.5 11.8 19 5.2 8.2 1.7 1 0 0 1 1 1 0 Cysteine-rich CWC DUF1929 PF09118.6 ESA18408.1 - 9.1e-06 25.6 0.0 9.6e-06 25.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Methyltransf_11 PF08241.7 ESA18409.1 - 6.6e-14 52.1 0.0 1.1e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18409.1 - 7e-11 42.3 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18409.1 - 1.3e-10 41.1 0.0 4.6e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18409.1 - 1.6e-09 37.6 0.0 2.5e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18409.1 - 1.2e-07 31.0 0.0 2.8e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA18409.1 - 6.9e-06 26.6 0.0 3.8e-05 24.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA18409.1 - 8.2e-06 25.3 0.0 1.4e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.7 ESA18409.1 - 1.9e-05 25.0 0.0 5.1e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA18409.1 - 0.00011 21.4 0.1 0.0008 18.6 0.0 2.3 1 1 1 2 2 2 1 Tellurite resistance protein TehB Methyltransf_2 PF00891.13 ESA18409.1 - 0.00063 19.0 0.0 0.00091 18.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 ESA18409.1 - 0.00091 19.2 0.0 0.0018 18.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA18409.1 - 0.0022 17.0 0.0 0.004 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 ESA18409.1 - 0.003 17.5 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.11 ESA18409.1 - 0.085 11.1 0.0 1.2 7.3 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TMEM71 PF15121.1 ESA18410.1 - 0.038 13.7 0.0 0.043 13.5 0.0 1.0 1 0 0 1 1 1 0 TMEM71 protein family zf-C2H2 PF00096.21 ESA18411.1 - 5.5e-16 57.8 39.4 0.0038 17.4 3.5 5.5 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA18411.1 - 8.2e-10 38.3 31.1 0.025 14.8 0.6 5.7 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA18411.1 - 0.0013 18.9 13.5 0.0042 17.3 1.0 5.6 5 1 0 5 5 5 3 Zinc-finger double domain Med3 PF11593.3 ESA18411.1 - 0.15 11.2 9.9 0.23 10.6 6.8 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal zf-C2HC_2 PF13913.1 ESA18411.1 - 0.43 10.3 4.9 15 5.4 0.0 3.6 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.1 ESA18413.1 - 0.028 14.3 5.9 0.17 11.8 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESA18413.1 - 0.039 14.2 2.8 0.063 13.6 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA18413.1 - 0.046 14.0 5.6 0.1 12.9 0.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA18413.1 - 0.76 10.0 6.3 0.16 12.1 1.3 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Crinivirus_P26 PF07416.6 ESA18414.1 - 0.0027 17.2 1.4 0.0028 17.1 1.0 1.1 1 0 0 1 1 1 1 Crinivirus P26 protein Corona_nucleoca PF00937.13 ESA18414.1 - 0.056 12.3 8.7 0.055 12.4 6.0 1.0 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Pkinase PF00069.20 ESA18415.1 - 2.9e-30 105.2 0.0 3.4e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18415.1 - 6.8e-30 104.0 0.0 7.3e-30 103.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA18415.1 - 0.00012 21.1 0.0 0.00015 20.8 0.0 1.0 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA18415.1 - 0.00095 18.2 0.0 0.0011 18.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA18415.1 - 0.0014 17.9 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA18415.1 - 0.0042 16.8 0.1 0.027 14.2 0.1 2.1 1 1 2 3 3 3 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA18415.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Rota_NS35 PF02509.9 ESA18415.1 - 0.12 11.0 0.9 0.69 8.5 0.1 1.9 1 1 1 2 2 2 0 Rotavirus non-structural protein 35 Pkinase PF00069.20 ESA18416.1 - 2.4e-10 39.9 0.1 3e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18416.1 - 4.8e-08 32.3 0.1 6.6e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Abhydrolase_6 PF12697.2 ESA18417.1 - 0.018 14.8 0.0 1.3 8.8 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA18417.1 - 0.058 12.9 0.0 1.4 8.4 0.0 2.0 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA18417.1 - 0.089 12.5 0.0 1.6 8.4 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF1043 PF06295.7 ESA18418.1 - 0.023 14.3 2.2 0.031 13.9 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF605 PF04652.11 ESA18418.1 - 3.3 6.9 15.1 4.1 6.7 10.4 1.0 1 0 0 1 1 1 0 Vta1 like RNR_inhib PF08591.5 ESA18418.1 - 3.4 8.6 6.8 5.4 8.0 4.7 1.5 1 1 0 1 1 1 0 Ribonucleotide reductase inhibitor DUF1888 PF08985.6 ESA18419.1 - 0.045 13.4 0.0 0.049 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1888) UPF0016 PF01169.14 ESA18421.1 - 1.9e-41 140.0 20.0 1.3e-21 76.4 6.3 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2208 PF09973.4 ESA18421.1 - 0.0059 15.8 0.0 0.0059 15.8 0.0 2.2 2 1 0 2 2 2 1 Predicted membrane protein (DUF2208) TerC PF03741.11 ESA18421.1 - 0.0066 15.9 2.8 0.0066 15.9 1.9 2.4 2 1 0 2 2 2 1 Integral membrane protein TerC family POP1 PF06978.6 ESA18422.1 - 1.3e-40 139.1 20.4 1.1e-23 83.8 6.5 2.4 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 ESA18422.1 - 7.9e-26 89.7 0.7 2.1e-25 88.3 0.5 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T PF01571.16 ESA18422.1 - 1.6e-05 24.4 0.0 0.00021 20.7 0.0 2.4 3 0 0 3 3 3 1 Aminomethyltransferase folate-binding domain CRCB PF02537.10 ESA18423.1 - 2.2e-35 121.0 16.1 5.4e-24 84.3 4.4 2.4 2 0 0 2 2 2 2 CrcB-like protein DUF2232 PF09991.4 ESA18423.1 - 0.0029 16.6 4.4 0.0029 16.6 3.0 2.4 2 1 1 3 3 3 1 Predicted membrane protein (DUF2232) Imm22 PF15592.1 ESA18425.1 - 0.013 15.7 0.6 0.024 14.9 0.2 1.6 1 1 0 1 1 1 0 Immunity protein 22 NPV_P10 PF05531.7 ESA18425.1 - 0.037 14.2 5.4 0.049 13.8 3.2 1.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein HSBP1 PF06825.7 ESA18425.1 - 0.075 12.6 3.4 5.3 6.6 2.4 2.5 1 1 0 1 1 1 0 Heat shock factor binding protein 1 DUF3201 PF11447.3 ESA18425.1 - 0.083 12.2 6.1 0.31 10.4 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3201) DUF2458 PF10454.4 ESA18425.1 - 0.11 12.4 13.6 9 6.1 9.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) Allexi_40kDa PF05549.6 ESA18425.1 - 0.14 11.4 4.1 0.15 11.3 2.8 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Rsd_AlgQ PF04353.8 ESA18425.1 - 0.16 11.6 3.7 0.23 11.1 2.5 1.4 1 1 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ RNA_pol_Rpb5_C PF01191.14 ESA18425.1 - 0.2 11.2 4.3 1.7 8.2 2.6 2.5 1 1 1 2 2 2 0 RNA polymerase Rpb5, C-terminal domain CDC37_N PF03234.9 ESA18425.1 - 0.3 11.4 12.1 0.36 11.1 2.6 2.0 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding DUF4375 PF14300.1 ESA18425.1 - 0.61 10.0 5.8 0.59 10.1 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) Nif11 PF07862.6 ESA18425.1 - 0.68 9.9 4.1 13 5.7 0.3 2.5 1 1 1 2 2 2 0 Nitrogen fixation protein of unknown function DUF4559 PF15112.1 ESA18425.1 - 1.4 7.9 10.0 1.5 7.8 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) AAA_23 PF13476.1 ESA18425.1 - 4 7.7 20.5 5 7.3 14.2 1.1 1 0 0 1 1 1 0 AAA domain TBPIP PF07106.8 ESA18425.1 - 5.3 6.5 17.7 6.6 6.2 11.5 1.7 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF3571 PF12095.3 ESA18425.1 - 5.4 7.3 7.6 4.4 7.5 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3571) V_ATPase_I PF01496.14 ESA18425.1 - 6.2 4.5 9.8 6.5 4.4 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.6 ESA18425.1 - 9.1 4.8 9.3 9.4 4.7 6.1 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF342 PF03961.8 ESA18425.1 - 10 4.4 13.0 11 4.3 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PIG-H PF10181.4 ESA18428.1 - 0.093 12.3 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component Pkinase_Tyr PF07714.12 ESA18430.1 - 3.7e-44 150.7 0.8 2.2e-43 148.2 0.5 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18430.1 - 7.4e-38 130.1 2.5 1.6e-27 96.2 1.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Sel1 PF08238.7 ESA18430.1 - 2.4e-06 27.9 0.1 0.034 14.7 0.0 2.7 2 0 0 2 2 2 2 Sel1 repeat Kdo PF06293.9 ESA18430.1 - 0.0042 16.1 0.0 0.0099 14.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA18430.1 - 0.19 11.4 0.0 0.58 9.8 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA18431.1 - 1.1e-40 139.4 0.1 7e-37 126.8 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18431.1 - 2.1e-33 115.5 0.1 7.5e-30 103.9 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Kdo PF06293.9 ESA18431.1 - 0.0024 16.9 0.1 0.0035 16.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA18431.1 - 0.016 14.9 0.1 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA18431.1 - 0.098 11.9 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 RIO1 family FliL PF03748.9 ESA18432.1 - 1.6 8.7 4.1 4.3 7.4 2.7 2.0 1 1 0 1 1 1 0 Flagellar basal body-associated protein FliL PRA-PH PF01503.12 ESA18432.1 - 2.4 8.4 6.9 97 3.3 4.8 2.5 1 1 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase PAS_3 PF08447.6 ESA18433.1 - 3.5e-05 23.8 0.0 7.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.19 ESA18433.1 - 0.013 15.2 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 PAS fold Pkinase_Tyr PF07714.12 ESA18436.1 - 1.7e-05 24.0 0.0 3.2e-05 23.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18436.1 - 0.0003 20.0 0.0 0.00082 18.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain CagE_TrbE_VirB PF03135.9 ESA18436.1 - 0.082 12.6 0.3 0.26 11.0 0.1 1.7 2 0 0 2 2 2 0 CagE, TrbE, VirB family, component of type IV transporter system ComC PF03047.9 ESA18436.1 - 0.35 10.3 0.1 0.35 10.3 0.1 2.2 2 0 0 2 2 2 0 COMC family Pkinase_Tyr PF07714.12 ESA18437.1 - 8.8e-45 152.7 0.1 8.1e-37 126.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18437.1 - 1.4e-40 139.1 0.3 4e-37 127.7 0.4 2.2 2 0 0 2 2 2 2 Protein kinase domain WaaY PF06176.6 ESA18437.1 - 6.4e-06 25.5 0.2 6.4e-06 25.5 0.1 2.3 3 0 0 3 3 3 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA18437.1 - 0.00033 20.4 0.0 0.0017 18.1 0.0 1.8 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA18437.1 - 0.0016 17.8 0.8 0.014 14.7 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA18437.1 - 0.0022 17.0 0.0 0.0043 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Sel1 PF08238.7 ESA18438.1 - 2.6e-85 278.9 33.5 8.3e-08 32.6 0.1 12.1 12 0 0 12 12 12 12 Sel1 repeat EpoR_lig-bind PF09067.5 ESA18438.1 - 0.17 11.8 3.3 2.3 8.2 0.1 3.2 2 1 1 3 3 3 0 Erythropoietin receptor, ligand binding Pkinase_Tyr PF07714.12 ESA18439.1 - 4.9e-11 42.1 0.0 1.2e-06 27.7 0.1 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18439.1 - 8e-11 41.5 0.0 2.5e-07 30.1 0.1 2.2 1 1 0 2 2 2 2 Protein kinase domain APH PF01636.18 ESA18439.1 - 0.012 15.3 0.1 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4613 PF15390.1 ESA18440.1 - 0.067 11.3 2.2 0.074 11.2 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2098 PF09871.4 ESA18440.1 - 0.12 12.2 5.9 0.074 12.9 2.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) DRY_EERY PF09750.4 ESA18440.1 - 2.5 8.1 8.7 2.8 8.0 2.4 2.1 1 1 1 2 2 2 0 Alternative splicing regulator Nuc_rec_co-act PF08815.5 ESA18441.1 - 0.0015 17.9 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Nuclear receptor coactivator DNA_pol3_a_NI PF14480.1 ESA18441.1 - 0.13 11.9 0.8 0.14 11.8 0.5 1.1 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus I Pkinase_Tyr PF07714.12 ESA18442.1 - 1.3e-16 60.5 0.1 2.1e-13 49.9 0.0 3.1 4 0 0 4 4 4 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18442.1 - 7e-13 48.3 3.9 2.4e-12 46.5 0.1 3.1 4 0 0 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ESA18442.1 - 5.9e-08 32.5 2.1 0.076 12.6 0.0 4.0 4 0 0 4 4 4 3 BCS1 N terminal Spt5-NGN PF03439.8 ESA18442.1 - 0.033 13.9 1.8 22 4.8 0.0 3.5 3 0 0 3 3 3 0 Early transcription elongation factor of RNA pol II, NGN section NOB1_Zn_bind PF08772.6 ESA18442.1 - 0.14 12.0 10.1 7.9 6.3 0.2 3.7 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like DUF2004 PF09406.5 ESA18442.1 - 0.34 10.9 11.1 1 9.4 0.1 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2004) DUF4413 PF14372.1 ESA18442.1 - 0.55 10.2 7.9 6.5 6.8 0.0 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) DUF16 PF01519.11 ESA18443.1 - 0.00028 21.0 2.4 0.00033 20.8 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF16 TBPIP PF07106.8 ESA18443.1 - 0.0012 18.3 3.7 0.0015 18.1 2.6 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TPR_MLP1_2 PF07926.7 ESA18443.1 - 0.0013 18.4 2.4 0.0016 18.1 1.7 1.1 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF342 PF03961.8 ESA18443.1 - 0.0037 15.7 3.1 0.0042 15.5 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF342) DUF3450 PF11932.3 ESA18443.1 - 0.0041 16.4 1.1 0.0046 16.2 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Tup_N PF08581.5 ESA18443.1 - 0.0047 17.0 4.1 0.0061 16.7 2.4 1.5 1 1 1 2 2 2 1 Tup N-terminal V_ATPase_I PF01496.14 ESA18443.1 - 0.005 14.7 2.5 0.0053 14.6 1.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF3919 PF13057.1 ESA18443.1 - 0.0075 15.7 3.6 0.0089 15.5 2.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3919) CENP-F_leu_zip PF10473.4 ESA18443.1 - 0.009 15.8 1.5 0.013 15.3 1.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.7 ESA18443.1 - 0.011 15.1 0.5 0.013 14.9 0.3 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF4254 PF14063.1 ESA18443.1 - 0.013 15.0 1.3 0.12 11.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4254) Striatin PF08232.7 ESA18443.1 - 0.014 15.6 0.9 0.017 15.3 0.6 1.1 1 0 0 1 1 1 0 Striatin family Spc24 PF08286.6 ESA18443.1 - 0.015 14.9 3.5 0.02 14.6 2.4 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 ERM PF00769.14 ESA18443.1 - 0.018 14.6 1.5 0.021 14.3 1.1 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Tropomyosin PF00261.15 ESA18443.1 - 0.023 13.8 1.8 0.027 13.5 1.2 1.1 1 0 0 1 1 1 0 Tropomyosin AAA_13 PF13166.1 ESA18443.1 - 0.034 12.6 4.5 0.035 12.5 3.1 1.0 1 0 0 1 1 1 0 AAA domain Macoilin PF09726.4 ESA18443.1 - 0.048 11.9 1.6 0.051 11.8 1.1 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF3584 PF12128.3 ESA18443.1 - 0.053 10.8 2.8 0.059 10.6 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Fib_alpha PF08702.5 ESA18443.1 - 0.058 13.5 3.2 0.097 12.7 2.2 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CENP-K PF11802.3 ESA18443.1 - 0.059 12.5 2.6 0.068 12.3 1.8 1.1 1 0 0 1 1 1 0 Centromere-associated protein K Prefoldin_2 PF01920.15 ESA18443.1 - 0.06 13.1 5.3 0.096 12.4 0.7 2.1 1 1 0 2 2 2 0 Prefoldin subunit Cluap1 PF10234.4 ESA18443.1 - 0.066 12.4 1.8 0.075 12.2 1.2 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 IncA PF04156.9 ESA18443.1 - 0.076 12.6 2.4 0.09 12.3 1.7 1.1 1 0 0 1 1 1 0 IncA protein DUF1140 PF06600.6 ESA18443.1 - 0.079 13.0 1.6 0.098 12.7 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1140) Synaptonemal_3 PF15191.1 ESA18443.1 - 0.095 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 P4Ha_N PF08336.6 ESA18443.1 - 0.1 12.3 1.1 0.14 11.9 0.8 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Sipho_Gp157 PF05565.6 ESA18443.1 - 0.11 12.1 2.7 0.2 11.2 1.9 1.5 1 1 0 1 1 1 0 Siphovirus Gp157 Prefoldin PF02996.12 ESA18443.1 - 0.12 12.0 3.9 0.12 11.9 0.7 1.8 1 1 1 2 2 2 0 Prefoldin subunit KxDL PF10241.4 ESA18443.1 - 0.15 12.0 2.4 0.68 9.8 0.2 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein APG6 PF04111.7 ESA18443.1 - 0.17 10.8 3.9 0.19 10.7 2.7 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Spectrin PF00435.16 ESA18443.1 - 0.18 12.0 4.2 0.31 11.3 2.9 1.5 1 1 0 1 1 1 0 Spectrin repeat WXG100 PF06013.7 ESA18443.1 - 0.2 11.7 1.3 6 6.9 0.2 2.1 1 1 1 2 2 2 0 Proteins of 100 residues with WXG DUF4407 PF14362.1 ESA18443.1 - 0.2 10.5 0.8 0.22 10.4 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MIF4G_like_2 PF09090.6 ESA18443.1 - 0.2 10.8 3.9 0.24 10.6 2.7 1.0 1 0 0 1 1 1 0 MIF4G like Atg14 PF10186.4 ESA18443.1 - 0.23 10.3 3.4 0.25 10.2 2.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Tropomyosin_1 PF12718.2 ESA18443.1 - 0.24 11.2 5.4 0.39 10.5 3.4 1.5 1 1 0 1 1 1 0 Tropomyosin like DivIC PF04977.10 ESA18443.1 - 0.29 10.6 4.8 0.45 10.0 3.1 1.6 1 1 1 2 2 2 0 Septum formation initiator Ax_dynein_light PF10211.4 ESA18443.1 - 0.32 10.8 4.5 0.37 10.5 3.1 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain RNA_polI_A14 PF08203.6 ESA18443.1 - 0.39 10.9 2.6 7.6 6.8 0.1 2.1 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Kinetocho_Slk19 PF12709.2 ESA18443.1 - 0.44 10.6 3.5 1.7 8.7 2.2 2.0 1 1 0 1 1 1 0 Central kinetochore-associated Snapin_Pallidin PF14712.1 ESA18443.1 - 0.69 10.2 3.7 4 7.8 2.5 1.9 1 1 1 2 2 2 0 Snapin/Pallidin Val_tRNA-synt_C PF10458.4 ESA18443.1 - 0.7 10.0 2.7 2.3 8.3 1.9 1.9 1 1 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm DUF2951 PF11166.3 ESA18443.1 - 0.95 9.3 4.5 3 7.7 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) bZIP_1 PF00170.16 ESA18443.1 - 1.9 8.4 5.6 4.4 7.3 1.5 2.1 1 1 1 2 2 2 0 bZIP transcription factor PYRIN PF02758.11 ESA18444.1 - 0.0072 15.9 0.3 0.11 12.1 0.1 2.7 2 0 0 2 2 2 1 PAAD/DAPIN/Pyrin domain UQ_con PF00179.21 ESA18445.1 - 7e-35 119.4 0.0 1.2e-34 118.7 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA18445.1 - 0.033 14.0 0.0 0.057 13.3 0.0 1.5 1 1 0 1 1 1 0 RWD domain Phage_holin_1 PF04531.8 ESA18445.1 - 0.074 13.1 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage holin Cu-oxidase PF00394.17 ESA18446.1 - 6.6e-36 123.6 0.0 2.9e-35 121.5 0.0 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA18446.1 - 3e-35 120.7 1.0 7.9e-35 119.3 0.7 1.7 2 0 0 2 2 2 1 Multicopper oxidase tRNA_U5-meth_tr PF05958.6 ESA18449.1 - 0.017 13.8 0.1 0.018 13.7 0.1 1.0 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Sel1 PF08238.7 ESA18450.1 - 3.5e-49 164.1 9.2 3.4e-12 46.5 0.0 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_17 PF13431.1 ESA18450.1 - 0.00073 19.5 0.6 11 6.4 0.0 4.5 5 1 0 5 5 5 1 Tetratricopeptide repeat RQC PF09382.5 ESA18450.1 - 0.0012 18.5 4.0 2.2 8.0 0.0 3.7 1 1 3 4 4 4 2 RQC domain PPR PF01535.15 ESA18450.1 - 0.0019 18.0 3.8 15 5.7 0.0 5.0 5 0 0 5 5 5 1 PPR repeat TPR_5 PF12688.2 ESA18450.1 - 0.0045 17.0 1.3 24 5.0 0.0 3.6 3 1 1 4 4 4 0 Tetratrico peptide repeat TPR_6 PF13174.1 ESA18450.1 - 0.0067 16.8 8.0 3.3 8.3 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18450.1 - 0.032 14.1 7.7 2.2 8.2 0.4 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat Viral_cys_rich PF08008.7 ESA18450.1 - 0.11 12.0 1.2 7.3 6.2 0.1 3.4 1 1 2 4 4 4 0 Viral cysteine rich TPR_10 PF13374.1 ESA18450.1 - 0.11 12.4 0.1 24 5.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ADH_zinc_N PF00107.21 ESA18451.1 - 1.4e-20 73.1 0.0 2.5e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA18451.1 - 2.4e-08 34.9 0.0 4.8e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TPR_11 PF13414.1 ESA18452.1 - 3.7e-12 45.7 1.0 7.7e-11 41.4 0.1 2.5 2 0 0 2 2 2 1 TPR repeat SET PF00856.23 ESA18452.1 - 0.0055 17.0 0.2 0.022 15.0 0.0 2.0 2 0 0 2 2 2 1 SET domain TPR_17 PF13431.1 ESA18452.1 - 0.011 15.8 0.1 0.038 14.1 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA18452.1 - 0.012 15.4 7.2 2.3 8.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 ESA18452.1 - 0.052 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA18452.1 - 0.073 12.7 2.1 30 4.4 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18452.1 - 0.11 13.2 0.0 0.2 12.3 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Erf4 PF10256.4 ESA18453.1 - 5 7.0 10.8 10 6.0 0.1 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family Minor_capsid_1 PF10665.4 ESA18453.1 - 5.2 6.9 8.3 4.1 7.2 1.8 2.0 1 1 1 2 2 2 0 Minor capsid protein Cytochrom_B562 PF07361.6 ESA18455.1 - 0.062 13.7 0.8 7.4 7.0 0.0 2.7 1 1 2 3 3 3 0 Cytochrome b562 Erf4 PF10256.4 ESA18455.1 - 0.22 11.4 7.5 3.3 7.5 0.0 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family Pkinase PF00069.20 ESA18456.1 - 0.0019 17.3 0.0 0.0022 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Orthopox_F6 PF06601.7 ESA18456.1 - 0.0022 17.8 0.4 0.0042 16.9 0.3 1.4 1 0 0 1 1 1 1 Orthopoxvirus F6 protein Sirohm_synth_C PF14823.1 ESA18456.1 - 0.076 12.3 0.1 0.25 10.6 0.0 1.8 1 1 1 2 2 2 0 Sirohaem biosynthesis protein C-terminal Sel1 PF08238.7 ESA18457.1 - 4e-33 113.1 22.1 3.3e-07 30.7 0.0 7.0 7 0 0 7 7 6 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA18457.1 - 2.2e-25 89.2 0.0 3.7e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18457.1 - 3.6e-21 75.4 0.0 6.3e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_16 PF13432.1 ESA18457.1 - 4.4e-06 27.2 8.8 0.13 13.0 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18457.1 - 5.8e-05 22.9 15.4 0.00056 19.7 2.4 4.7 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA18457.1 - 0.00022 20.6 2.7 0.00022 20.6 1.9 5.9 7 1 1 8 8 6 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA18457.1 - 0.00023 20.7 20.2 0.0044 16.6 5.4 5.1 3 2 3 6 6 5 1 TPR repeat TPR_2 PF07719.12 ESA18457.1 - 0.0013 18.4 1.6 0.0013 18.4 1.1 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESA18457.1 - 0.024 14.5 4.1 0.76 9.8 0.2 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat APH PF01636.18 ESA18457.1 - 0.031 14.0 0.2 0.051 13.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_14 PF13428.1 ESA18457.1 - 0.039 14.5 1.8 4.4 8.1 0.1 4.3 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18457.1 - 0.047 14.1 11.0 6.2 7.5 0.6 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA18457.1 - 0.14 12.0 8.6 0.17 11.7 0.3 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF2779 PF11074.3 ESA18457.1 - 0.15 12.0 1.1 0.28 11.2 0.3 1.8 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) Apc3 PF12895.2 ESA18457.1 - 0.87 9.7 13.7 0.78 9.9 2.2 4.2 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 ESA18457.1 - 1.1 9.2 17.2 0.049 13.4 1.6 5.1 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18457.1 - 9.3 6.7 19.5 4.9 7.6 0.6 5.9 5 1 1 6 6 6 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.12 ESA18458.1 - 0.0028 16.7 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA18459.1 - 1.1e-15 57.4 0.2 1.2e-15 57.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18459.1 - 1.7e-13 50.3 1.0 1.8e-13 50.2 0.7 1.1 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.27 ESA18460.1 - 2.6e-11 42.9 1.6 8.5e-08 31.8 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 ESA18460.1 - 2.2e-05 22.9 0.1 5.6e-05 21.6 0.0 1.7 2 0 0 2 2 2 1 Cytochrome D1 heme domain DUF2415 PF10313.4 ESA18460.1 - 0.0001 21.8 0.1 0.00023 20.7 0.1 1.6 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) eIF2A PF08662.6 ESA18460.1 - 0.0099 15.6 0.0 0.11 12.2 0.0 1.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A zf-C2H2_jaz PF12171.3 ESA18461.1 - 1.5e-05 25.0 1.4 0.2 11.8 0.1 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 ESA18461.1 - 4.7e-05 23.4 5.8 0.0098 16.0 1.7 2.9 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 ESA18461.1 - 0.0005 20.2 4.5 0.014 15.6 0.1 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA18461.1 - 0.00073 19.7 5.6 0.15 12.4 0.1 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type LIM PF00412.17 ESA18461.1 - 0.029 14.4 1.3 0.07 13.2 0.9 1.6 1 1 0 1 1 1 0 LIM domain zf-C2H2_6 PF13912.1 ESA18461.1 - 0.083 12.8 1.5 2.2 8.2 0.0 2.4 1 1 1 2 2 2 0 C2H2-type zinc finger zf-FCS PF06467.9 ESA18461.1 - 0.12 12.0 3.5 6.9 6.3 0.8 2.6 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Elf-1_N PF12310.3 ESA18461.1 - 0.13 12.2 3.0 1.4 8.9 0.2 2.4 2 0 0 2 2 2 0 Transcription factor protein N terminal PyrI_C PF02748.10 ESA18461.1 - 0.68 9.4 3.6 2.7 7.4 0.2 2.4 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Ima1_N PF09779.4 ESA18461.1 - 2.1 8.8 10.4 0.22 12.0 0.9 2.8 2 1 1 3 3 3 0 Ima1 N-terminal domain zf-H2C2_2 PF13465.1 ESA18461.1 - 2.3 8.6 8.0 0.43 10.9 1.7 2.4 2 0 0 2 2 2 0 Zinc-finger double domain PAH PF02671.16 ESA18462.1 - 6.1e-49 163.4 10.9 2.9e-19 68.4 1.3 3.7 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 ESA18462.1 - 5.9e-41 138.3 0.1 1.6e-40 136.9 0.1 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor UPF0259 PF06790.6 ESA18462.1 - 0.36 10.2 0.0 0.72 9.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0259) Tau95 PF09734.4 ESA18463.1 - 2.2e-63 214.4 0.9 2.8e-63 214.1 0.6 1.1 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit DUF836 PF05768.9 ESA18464.1 - 5.8e-16 58.5 0.4 6.7e-16 58.3 0.3 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 ESA18464.1 - 0.027 14.4 0.6 0.056 13.4 0.2 1.8 1 1 1 2 2 2 0 Glutaredoxin DUF1223 PF06764.6 ESA18464.1 - 0.04 13.7 0.0 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) SET_assoc PF11767.3 ESA18464.1 - 0.077 12.3 0.3 0.9 8.9 0.1 2.1 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_1 PF00076.17 ESA18465.1 - 2.1e-36 123.3 2.8 7.6e-19 67.1 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18465.1 - 1.1e-27 95.7 0.3 8.1e-14 51.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18465.1 - 8.1e-13 48.0 0.0 5.3e-08 32.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.10 ESA18465.1 - 0.0046 16.5 0.2 0.11 12.2 0.0 2.4 2 0 0 2 2 2 1 DbpA RNA binding domain OB_RNB PF08206.6 ESA18465.1 - 0.026 14.0 0.0 12 5.4 0.0 2.9 2 0 0 2 2 2 0 Ribonuclease B OB domain NIL PF09383.5 ESA18465.1 - 0.05 13.1 0.1 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 NIL domain API5 PF05918.6 ESA18465.1 - 0.62 8.4 19.1 0.0092 14.5 2.7 2.2 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) F-box-like PF12937.2 ESA18466.1 - 0.0032 17.1 0.9 0.014 15.1 0.6 2.0 1 0 0 1 1 1 1 F-box-like DUF3657 PF12394.3 ESA18466.1 - 0.021 14.8 0.2 0.061 13.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3657) FAR1 PF03101.10 ESA18468.1 - 1.5e-05 25.4 0.1 2.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Trp_halogenase PF04820.9 ESA18468.1 - 0.052 12.1 0.1 0.052 12.1 0.0 1.0 1 0 0 1 1 1 0 Tryptophan halogenase Pkinase PF00069.20 ESA18469.1 - 2.7e-20 72.5 0.0 3e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18469.1 - 1.3e-19 70.3 0.0 1.4e-19 70.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18469.1 - 0.0015 18.3 0.5 0.0024 17.6 0.4 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA18469.1 - 0.017 14.2 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA18469.1 - 0.02 14.2 0.1 0.024 14.0 0.1 1.1 1 0 0 1 1 1 0 RIO1 family PB1 PF00564.19 ESA18470.1 - 2.3e-05 23.9 0.1 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 PB1 domain DUF2758 PF10957.3 ESA18470.1 - 0.015 15.0 1.2 0.027 14.2 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2758) Sel1 PF08238.7 ESA18471.1 - 2.1e-40 136.2 8.4 8.7e-12 45.2 0.4 4.3 4 0 0 4 4 4 4 Sel1 repeat MIT PF04212.13 ESA18471.1 - 0.013 15.3 15.5 0.59 10.0 3.8 4.1 1 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain GerPC PF10737.4 ESA18471.1 - 0.048 13.4 0.6 0.072 12.8 0.4 1.3 1 0 0 1 1 1 0 Spore germination protein GerPC NSF PF02071.15 ESA18471.1 - 0.15 12.6 3.1 97 4.3 0.1 4.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat BACK PF07707.10 ESA18472.1 - 5.5e-08 32.5 3.0 2.7e-05 23.9 0.5 3.2 2 1 1 3 3 3 2 BTB And C-terminal Kelch BTB PF00651.26 ESA18472.1 - 1.7e-07 31.1 0.5 5.9e-07 29.4 0.4 1.9 1 1 0 1 1 1 1 BTB/POZ domain Bcl-2 PF00452.14 ESA18472.1 - 0.054 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Pkinase_Tyr PF07714.12 ESA18474.1 - 5.4e-54 182.9 0.0 9.3e-54 182.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18474.1 - 3.6e-51 173.8 0.1 9.3e-51 172.4 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain AIG1 PF04548.11 ESA18474.1 - 1.2e-16 60.5 6.4 4.6e-14 52.0 0.5 2.6 2 0 0 2 2 2 2 AIG1 family MMR_HSR1 PF01926.18 ESA18474.1 - 0.0002 21.2 1.5 0.0025 17.7 1.0 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA18474.1 - 0.0013 17.9 0.3 0.029 13.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 LRR_4 PF12799.2 ESA18474.1 - 0.0054 16.3 39.1 0.0086 15.6 0.0 7.2 2 2 3 5 5 5 1 Leucine Rich repeats (2 copies) T2SE PF00437.15 ESA18474.1 - 0.076 11.8 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein APH PF01636.18 ESA18474.1 - 0.089 12.5 0.0 0.41 10.3 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family LRR_7 PF13504.1 ESA18474.1 - 0.12 12.6 27.7 41 5.0 0.5 9.8 8 1 0 8 8 8 0 Leucine rich repeat ABC_tran PF00005.22 ESA18474.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.3 2 1 0 2 2 2 0 ABC transporter LRR_1 PF00560.28 ESA18474.1 - 1.4 9.2 28.5 27 5.3 0.4 9.3 6 3 1 7 7 7 0 Leucine Rich Repeat BTB PF00651.26 ESA18475.1 - 7.4e-08 32.3 0.0 7.6e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain DUF581 PF04570.9 ESA18479.1 - 0.026 13.8 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF581) ubiquitin PF00240.18 ESA18480.1 - 8.1e-40 134.0 12.9 2.4e-15 55.6 0.1 5.5 6 0 0 6 6 6 4 Ubiquitin family Rad60-SLD PF11976.3 ESA18480.1 - 5.6e-28 96.4 8.7 3.8e-09 36.1 0.3 5.2 4 1 1 5 5 5 4 Ubiquitin-2 like Rad60 SUMO-like ZZ PF00569.12 ESA18480.1 - 1.2e-08 34.2 5.9 1.2e-08 34.2 4.1 1.6 2 0 0 2 2 2 1 Zinc finger, ZZ type Ubiquitin_2 PF14560.1 ESA18480.1 - 0.0023 18.1 6.8 1.3 9.3 0.1 3.9 3 1 0 3 3 3 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA18480.1 - 0.0072 16.2 0.2 15 5.5 0.0 3.7 2 1 1 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like CTDII PF01556.13 ESA18480.1 - 0.011 15.6 0.2 0.13 12.1 0.0 2.6 3 0 0 3 3 3 0 DnaJ C terminal domain UBX PF00789.15 ESA18480.1 - 0.02 14.9 0.0 3.7 7.6 0.0 3.0 3 0 0 3 3 3 0 UBX domain Peptidase_S55 PF05580.7 ESA18480.1 - 0.045 13.2 1.0 6.7 6.0 0.1 2.9 2 1 1 3 3 3 0 SpoIVB peptidase S55 TUG-UBL1 PF11470.3 ESA18480.1 - 0.08 12.8 5.0 7.4 6.5 0.1 3.8 4 0 0 4 4 4 0 GLUT4 regulating protein TUG CLU_N PF15044.1 ESA18480.1 - 0.16 12.1 7.4 7.2 6.8 0.0 4.6 3 3 1 4 4 4 0 Mitochondrial function, CLU-N-term DUF720 PF05302.6 ESA18480.1 - 0.17 11.6 2.5 3 7.6 0.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF720) NETI PF14044.1 ESA18480.1 - 0.2 11.1 1.5 0.41 10.1 0.1 2.1 2 0 0 2 2 2 0 NETI protein DUF4101 PF13355.1 ESA18480.1 - 0.23 11.8 3.2 1.8 8.9 0.1 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF4101) C1_3 PF07649.7 ESA18480.1 - 1.6 8.8 11.2 0.29 11.2 5.1 1.8 2 0 0 2 2 2 0 C1-like domain zf-B_box PF00643.19 ESA18480.1 - 2.6 7.9 6.5 5.3 7.0 4.5 1.6 1 0 0 1 1 1 0 B-box zinc finger MMR_HSR1 PF01926.18 ESA18481.1 - 0.0019 18.1 0.0 0.0047 16.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA18481.1 - 0.0048 16.7 0.0 0.026 14.3 0.0 1.9 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.11 ESA18481.1 - 0.0089 15.1 0.0 0.058 12.4 0.0 2.2 3 0 0 3 3 3 1 AIG1 family FtsK_SpoIIIE PF01580.13 ESA18481.1 - 0.018 14.5 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF258 PF03193.11 ESA18481.1 - 0.037 13.2 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF87 PF01935.12 ESA18481.1 - 0.067 12.9 0.0 0.45 10.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF87 RNA_helicase PF00910.17 ESA18481.1 - 0.094 12.9 0.0 0.77 9.9 0.0 2.2 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.22 ESA18481.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 2 0 0 2 2 2 0 ABC transporter Rad60-SLD PF11976.3 ESA18482.1 - 0.0024 17.5 0.3 0.024 14.3 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Adeno_Penton_B PF01686.12 ESA18482.1 - 0.003 15.8 0.0 0.0046 15.2 0.0 1.3 1 0 0 1 1 1 1 Adenovirus penton base protein ENTH PF01417.15 ESA18482.1 - 0.085 12.7 0.2 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 ENTH domain Sel1 PF08238.7 ESA18484.1 - 5.5e-56 185.7 19.6 1.3e-12 47.9 0.3 7.1 7 0 0 7 7 7 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA18484.1 - 1.2e-49 168.7 0.0 1.7e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18484.1 - 1.3e-48 165.4 0.1 2.4e-48 164.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA18484.1 - 9.3e-05 21.7 0.3 0.00019 20.7 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA18484.1 - 0.00016 20.7 0.0 0.0029 16.6 0.0 2.3 3 0 0 3 3 3 1 Kinase-like APH PF01636.18 ESA18484.1 - 0.021 14.5 0.1 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA18484.1 - 0.024 13.6 0.0 0.045 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA18485.1 - 6.2e-47 159.8 0.0 8.1e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18485.1 - 8.2e-46 156.2 0.1 1.4e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA18485.1 - 0.00033 20.0 0.3 0.001 18.4 0.2 1.8 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA18485.1 - 0.00062 18.8 0.0 0.011 14.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 ESA18485.1 - 0.013 15.2 0.8 0.041 13.6 0.6 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family ABC1 PF03109.11 ESA18485.1 - 0.078 12.9 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 ABC1 family Skp1_POZ PF03931.10 ESA18486.1 - 3.1 7.9 6.5 5.3 7.2 0.4 3.3 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain HTH_Tnp_IS630 PF01710.11 ESA18489.1 - 0.014 15.0 0.6 0.038 13.6 0.0 1.9 2 0 0 2 2 2 0 Transposase HTH_32 PF13565.1 ESA18489.1 - 0.13 13.0 0.0 0.27 12.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain YLP PF02757.12 ESA18489.1 - 0.26 11.0 1.5 0.53 10.1 1.0 1.5 1 0 0 1 1 1 0 YLP motif Transcrip_act PF04949.8 ESA18490.1 - 0.085 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Transcriptional activator DUF3687 PF12459.3 ESA18492.1 - 5.5 6.3 10.9 2.6 7.3 1.6 2.4 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein GPI-anchored PF10342.4 ESA18494.1 - 0.13 12.7 0.8 0.28 11.6 0.3 1.7 2 1 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family p450 PF00067.17 ESA18495.1 - 9.2e-50 169.4 0.8 1.6e-49 168.7 0.5 1.3 1 1 0 1 1 1 1 Cytochrome P450 Inhibitor_I67 PF11405.3 ESA18495.1 - 0.0032 17.4 0.1 0.012 15.6 0.1 2.0 1 0 0 1 1 1 1 Bromelain inhibitor VI Pkinase PF00069.20 ESA18496.1 - 5.2e-13 48.7 0.2 1.6e-12 47.1 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA18496.1 - 1.6e-06 27.5 0.1 3.3e-06 26.5 0.1 1.5 1 1 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 ESA18496.1 - 0.00046 19.3 0.1 0.041 12.9 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Fructosamin_kin PF03881.9 ESA18496.1 - 0.0011 18.0 0.0 0.0031 16.5 0.0 1.5 1 1 1 2 2 2 1 Fructosamine kinase APH PF01636.18 ESA18496.1 - 0.002 17.9 0.0 0.059 13.0 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA18496.1 - 0.021 14.3 0.1 0.038 13.5 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RBD-FIP PF09457.5 ESA18496.1 - 0.065 13.0 0.2 0.35 10.6 0.0 2.3 2 0 0 2 2 2 0 FIP domain WSC PF01822.14 ESA18497.1 - 3.6e-25 87.6 29.8 8.5e-18 64.0 9.7 2.6 3 0 0 3 3 3 2 WSC domain SKG6 PF08693.5 ESA18497.1 - 0.036 13.3 3.3 0.062 12.6 2.3 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain F-box-like PF12937.2 ESA18498.1 - 3.4e-06 26.6 0.4 1.2e-05 24.9 0.2 2.0 1 1 0 1 1 1 1 F-box-like F-box PF00646.28 ESA18498.1 - 0.1 12.2 5.6 2.3 7.9 1.5 3.7 2 1 0 2 2 2 0 F-box domain DUF4321 PF14209.1 ESA18499.1 - 3.4 7.4 5.9 0.83 9.3 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) DUF1529 PF07485.6 ESA18500.1 - 0.036 13.7 0.1 0.057 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1259) Pkinase_Tyr PF07714.12 ESA18501.1 - 1.8e-34 119.0 0.0 2.5e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18501.1 - 1.4e-28 99.8 0.0 2.3e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA18501.1 - 0.11 11.7 0.1 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) zf-B_box PF00643.19 ESA18501.1 - 0.16 11.8 0.8 0.38 10.6 0.6 1.6 1 0 0 1 1 1 0 B-box zinc finger Pkinase_Tyr PF07714.12 ESA18502.1 - 2e-32 112.2 0.0 2.3e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18502.1 - 7e-25 87.6 0.0 8.6e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain AIF_C PF14721.1 ESA18505.1 - 0.075 13.2 3.4 0.097 12.9 2.3 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Tom37_C PF11801.3 ESA18505.1 - 0.14 12.0 2.9 0.16 11.8 2.0 1.2 1 0 0 1 1 1 0 Tom37 C-terminal domain Pox_Ag35 PF03286.9 ESA18505.1 - 0.16 11.4 11.8 0.19 11.2 8.2 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.11 ESA18505.1 - 0.17 10.8 9.3 0.18 10.7 6.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.7 ESA18505.1 - 0.23 10.5 20.7 0.27 10.3 14.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF1510 PF07423.6 ESA18505.1 - 0.24 10.7 13.9 0.28 10.5 9.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) YqfQ PF14181.1 ESA18505.1 - 0.29 11.1 6.7 0.34 10.9 4.7 1.1 1 0 0 1 1 1 0 YqfQ-like protein Spore_coat_CotO PF14153.1 ESA18505.1 - 0.31 10.4 9.2 0.34 10.3 6.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO RNA_polI_A34 PF08208.6 ESA18505.1 - 0.38 10.4 8.6 0.4 10.3 6.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SID-1_RNA_chan PF13965.1 ESA18505.1 - 0.38 8.8 1.7 0.39 8.8 1.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3381 PF11861.3 ESA18505.1 - 0.45 10.0 15.0 0.62 9.5 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DDHD PF02862.12 ESA18505.1 - 0.46 10.2 3.5 0.53 10.0 2.4 1.1 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.5 ESA18505.1 - 0.5 10.3 8.5 0.62 10.0 5.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 VID27 PF08553.5 ESA18505.1 - 0.54 8.4 11.4 0.56 8.3 7.9 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Nop14 PF04147.7 ESA18505.1 - 0.69 7.7 18.9 0.78 7.5 13.1 1.0 1 0 0 1 1 1 0 Nop14-like family GOLD_2 PF13897.1 ESA18505.1 - 0.7 10.1 5.1 0.92 9.7 3.5 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Sigma70_ner PF04546.8 ESA18505.1 - 0.93 9.0 11.0 1.2 8.6 7.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Tim54 PF11711.3 ESA18505.1 - 1.4 7.4 6.5 1.6 7.2 4.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.17 ESA18505.1 - 1.5 7.7 3.5 1.7 7.5 2.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter BUD22 PF09073.5 ESA18505.1 - 1.5 7.8 14.7 1.7 7.6 10.2 1.0 1 0 0 1 1 1 0 BUD22 CKAP2_C PF15297.1 ESA18505.1 - 1.7 7.3 8.2 2 7.1 5.7 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Paf1 PF03985.8 ESA18505.1 - 1.9 7.1 16.0 2.3 6.8 11.1 1.0 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.9 ESA18505.1 - 2.4 6.1 13.9 2.8 5.8 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Fmp27 PF10344.4 ESA18505.1 - 2.4 5.7 5.5 2.7 5.5 3.8 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Sec62 PF03839.11 ESA18505.1 - 2.5 7.4 4.3 2.7 7.3 3.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Daxx PF03344.10 ESA18505.1 - 2.6 6.4 16.9 2.9 6.2 11.7 1.0 1 0 0 1 1 1 0 Daxx Family RRN3 PF05327.6 ESA18505.1 - 4.3 5.3 8.8 4.5 5.2 6.1 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CENP-T PF15511.1 ESA18505.1 - 4.3 6.4 9.8 5 6.2 6.8 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T TFIIF_alpha PF05793.7 ESA18505.1 - 5 5.3 21.1 6.1 5.0 14.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 PF03666.8 ESA18505.1 - 6.2 5.2 5.9 7 5.0 4.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ycf1 PF05758.7 ESA18505.1 - 7.9 4.0 6.5 7.9 4.0 4.5 1.0 1 0 0 1 1 1 0 Ycf1 RNase_H PF00075.19 ESA18507.1 - 0.0001 22.6 0.1 0.00012 22.4 0.0 1.2 1 0 0 1 1 1 1 RNase H HECT PF00632.20 ESA18508.1 - 0.00021 20.5 1.1 0.00037 19.7 0.7 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PRESAN PF09687.5 ESA18508.1 - 0.01 15.8 5.3 0.01 15.8 3.7 3.1 1 1 0 2 2 2 0 Plasmodium RESA N-terminal DUF3760 PF12586.3 ESA18508.1 - 0.087 12.6 0.0 8.5 6.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) Nop14 PF04147.7 ESA18510.1 - 0.063 11.1 27.6 0.078 10.8 19.2 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA18510.1 - 0.08 10.9 16.4 0.11 10.5 11.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 ESA18510.1 - 0.27 9.6 22.0 0.33 9.3 15.2 1.1 1 0 0 1 1 1 0 Daxx Family COPI_C PF06957.6 ESA18510.1 - 0.65 8.4 7.3 0.71 8.3 5.1 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF1510 PF07423.6 ESA18510.1 - 7.3 5.8 20.2 12 5.1 14.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Glypican PF01153.14 ESA18510.1 - 8.6 4.8 7.2 12 4.3 5.0 1.2 1 0 0 1 1 1 0 Glypican CDC45 PF02724.9 ESA18511.1 - 0.024 12.6 15.9 0.051 11.6 11.0 1.5 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 ESA18511.1 - 0.5 8.2 32.3 1 7.2 22.4 1.5 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 ESA18511.1 - 4.1 6.6 36.9 9.2 5.4 25.6 1.5 1 1 0 1 1 1 0 SDA1 CobT PF06213.7 ESA18511.1 - 6.8 5.7 34.9 13 4.7 24.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT WD-3 PF09765.4 ESA18514.1 - 7.8e-40 136.9 0.4 8.9e-40 136.7 0.2 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.3 ESA18514.1 - 3.2e-25 87.8 4.1 5.1e-25 87.2 2.8 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.1 ESA18514.1 - 2.9e-05 23.8 4.2 4.8e-05 23.1 2.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA18514.1 - 4e-05 23.6 1.0 7e-05 22.8 0.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESA18514.1 - 0.095 12.5 3.0 0.26 11.1 2.1 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 ESA18514.1 - 0.11 12.4 1.9 0.3 11.1 1.3 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 ESA18514.1 - 0.2 11.6 2.7 0.52 10.3 1.9 1.7 1 1 0 1 1 1 0 RING-like domain HSP70 PF00012.15 ESA18515.1 - 4.2e-07 28.2 0.0 0.00024 19.1 0.0 2.6 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA18515.1 - 0.0017 17.0 0.0 0.01 14.4 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Ibs_toxin PF13956.1 ESA18516.1 - 0.54 10.1 4.1 13 5.6 0.1 2.4 2 0 0 2 2 2 0 Toxin Ibs, type I toxin-antitoxin system MreB_Mbl PF06723.8 ESA18517.1 - 4.7e-06 25.4 0.0 0.00039 19.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA18517.1 - 0.00062 17.8 0.0 0.0017 16.3 0.0 1.5 1 1 0 1 1 1 1 Hsp70 protein Glu-tRNAGln PF02686.10 ESA18518.1 - 0.0015 18.2 0.5 0.002 17.9 0.4 1.3 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Aminotran_3 PF00202.16 ESA18519.1 - 2.2e-104 348.9 0.0 2.7e-104 348.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 ESA18519.1 - 0.056 12.3 0.0 0.11 11.4 0.0 1.5 1 1 0 1 1 1 0 Aminotransferase class I and II Peptidase_M36 PF02128.10 ESA18520.1 - 2.3e-150 500.6 4.0 3.4e-150 500.0 2.8 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.8 ESA18520.1 - 4.5e-11 42.0 2.1 1.1e-10 40.8 1.5 1.7 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.10 ESA18520.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain p450 PF00067.17 ESA18525.1 - 1.2e-13 50.4 0.0 1.7e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 LRR_6 PF13516.1 ESA18526.1 - 8.5 6.7 6.8 88 3.6 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeat SDA1 PF05285.7 ESA18527.1 - 0.29 10.3 24.2 0.36 10.0 16.8 1.2 1 0 0 1 1 1 0 SDA1 F-box-like PF12937.2 ESA18529.1 - 0.0068 16.1 0.4 0.014 15.0 0.3 1.5 1 0 0 1 1 1 1 F-box-like DCR PF14047.1 ESA18530.1 - 0.079 13.2 0.7 1.4 9.2 0.1 2.8 2 1 2 4 4 4 0 Dppa2/4 conserved region Prenyltransf PF01255.14 ESA18531.1 - 3.3e-75 252.0 0.6 3.9e-75 251.7 0.4 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase ArsR PF09824.4 ESA18531.1 - 0.17 11.1 2.2 1.3 8.2 1.5 2.4 1 1 0 1 1 1 0 ArsR transcriptional regulator ERCC4 PF02732.10 ESA18532.1 - 2.7e-11 43.3 2.1 8.4e-11 41.8 0.4 2.5 2 0 0 2 2 2 1 ERCC4 domain CUE PF02845.11 ESA18532.1 - 0.11 12.0 3.7 1.3 8.5 0.0 3.2 3 0 0 3 3 3 0 CUE domain SprA-related PF12118.3 ESA18532.1 - 6.6 5.9 19.3 13 4.9 13.4 1.6 1 0 0 1 1 1 0 SprA-related family TPR_11 PF13414.1 ESA18533.1 - 1.2e-19 69.7 14.8 3.8e-09 36.0 3.4 4.3 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 ESA18533.1 - 9.6e-19 66.1 11.1 3.3e-06 26.4 0.0 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESA18533.1 - 9.7e-15 53.2 10.3 0.012 15.4 0.0 5.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18533.1 - 5.9e-12 44.7 11.0 0.0035 17.4 0.1 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA18533.1 - 1.2e-11 44.1 10.5 0.039 14.5 0.0 5.8 3 2 3 6 6 5 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA18533.1 - 8.3e-10 38.8 9.1 0.0027 18.0 0.7 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18533.1 - 5.9e-08 33.1 11.0 0.00032 21.2 0.1 4.3 3 2 2 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18533.1 - 2.3e-07 30.6 7.4 0.011 15.6 1.4 3.6 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA18533.1 - 4.3e-06 26.1 7.6 0.78 9.6 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA18533.1 - 4.7e-06 26.6 3.4 0.0006 19.9 0.7 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.1 ESA18533.1 - 7.9e-06 25.9 10.6 0.0052 16.8 0.2 4.8 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESA18533.1 - 0.00015 21.5 2.1 0.13 12.1 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA18533.1 - 0.0016 18.0 1.1 12 5.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18533.1 - 0.012 16.0 11.8 1.2 9.7 0.4 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA18533.1 - 0.87 9.6 5.4 0.99 9.4 0.7 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.19 ESA18534.1 - 8.7e-14 51.3 0.1 1.4e-13 50.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA18534.1 - 2e-11 43.8 0.1 2.7e-11 43.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA18534.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.4 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_3 PF13302.1 ESA18534.1 - 0.059 13.5 0.0 0.078 13.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain BTB PF00651.26 ESA18537.1 - 2.8e-19 69.1 0.0 7.3e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain MATH PF00917.21 ESA18537.1 - 0.004 17.3 0.3 0.0089 16.2 0.2 1.6 1 0 0 1 1 1 1 MATH domain Peptidase_M30 PF10460.4 ESA18537.1 - 0.0046 15.8 0.1 0.0083 15.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase M30 Fic PF02661.13 ESA18538.1 - 8.3e-17 61.6 0.0 2.1e-16 60.3 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family RNase_P_p30 PF01876.11 ESA18539.1 - 4.8e-54 181.6 0.2 8.8e-54 180.8 0.1 1.5 2 0 0 2 2 2 1 RNase P subunit p30 Pro_isomerase PF00160.16 ESA18540.1 - 6.3e-49 166.1 0.8 3.4e-48 163.7 0.1 2.3 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.27 ESA18540.1 - 4.5e-13 48.5 2.4 2e-05 24.2 0.0 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat F-box-like PF12937.2 ESA18544.1 - 0.0015 18.2 2.5 0.0024 17.5 1.8 1.5 1 1 0 1 1 1 1 F-box-like dsrm PF00035.20 ESA18545.1 - 4.7e-08 33.4 0.3 0.0028 18.1 0.1 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif Herpes_UL25 PF01499.11 ESA18545.1 - 0.099 10.9 5.0 0.84 7.8 0.4 2.0 1 1 1 2 2 2 0 Herpesvirus UL25 family TFIID-18kDa PF02269.11 ESA18545.1 - 0.18 11.6 2.3 0.66 9.8 0.2 2.3 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit Interfer-bind PF09294.5 ESA18545.1 - 0.82 9.7 7.5 3.5 7.7 0.0 2.9 3 1 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III SAMP PF05924.6 ESA18547.1 - 0.15 11.2 0.5 0.95 8.6 0.1 2.1 2 0 0 2 2 2 0 SAMP Motif UvrD_C PF13361.1 ESA18548.1 - 2.6e-07 30.4 0.1 0.0027 17.2 0.0 2.2 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ESA18548.1 - 0.00034 20.0 0.3 0.00052 19.4 0.1 1.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.1 ESA18548.1 - 0.0013 18.8 0.0 0.0032 17.5 0.0 1.6 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain DUF3485 PF11984.3 ESA18550.1 - 0.013 14.5 0.0 0.027 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3485) 7TMR-HDED PF07697.6 ESA18550.1 - 0.029 14.1 0.6 0.053 13.2 0.4 1.5 1 0 0 1 1 1 0 7TM-HD extracellular Olfactory_mark PF06554.7 ESA18552.1 - 0.037 13.5 2.0 0.069 12.6 0.2 2.0 1 1 0 2 2 2 0 Olfactory marker protein Gln-synt_C PF00120.19 ESA18553.1 - 5.7e-64 215.7 0.0 6.8e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 ESA18553.1 - 3.3e-17 61.8 0.0 6.2e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DUF667 PF05018.8 ESA18556.1 - 2.9e-84 281.0 0.2 3.4e-84 280.8 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) B3 PF02362.16 ESA18558.1 - 0.069 12.8 0.1 0.076 12.6 0.1 1.1 1 0 0 1 1 1 0 B3 DNA binding domain Alk_phosphatase PF00245.15 ESA18558.1 - 0.075 11.7 0.0 0.075 11.7 0.0 1.1 1 0 0 1 1 1 0 Alkaline phosphatase CDC45 PF02724.9 ESA18559.1 - 0.075 11.0 3.4 0.07 11.1 2.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 ESA18559.1 - 3.2 5.5 12.2 3.6 5.3 8.4 1.0 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.6 ESA18559.1 - 3.2 5.7 10.1 4.1 5.3 7.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_r3 PF04539.11 ESA18562.1 - 0.17 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Sigma-70 region 3 HMG_box PF00505.14 ESA18563.1 - 8.8e-08 32.3 0.3 1.2e-07 31.8 0.2 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18563.1 - 0.0088 16.3 0.2 0.013 15.8 0.1 1.2 1 0 0 1 1 1 1 HMG-box domain DUF3619 PF12279.3 ESA18564.1 - 0.017 15.2 0.0 0.039 14.0 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3619) uDENN PF03456.13 ESA18564.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 uDENN domain GCR1_C PF12550.3 ESA18565.1 - 1.1e-13 50.8 1.0 2.3e-13 49.8 0.7 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Flu_C_NS1 PF03506.8 ESA18566.1 - 0.014 15.1 0.0 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Influenza C non-structural protein (NS1) Beach PF02138.13 ESA18567.1 - 2e-64 217.6 0.1 1.2e-63 215.1 0.0 2.3 2 0 0 2 2 2 1 Beige/BEACH domain WD40 PF00400.27 ESA18567.1 - 2.8e-11 42.8 13.6 1.2e-07 31.3 0.0 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat Pkinase PF00069.20 ESA18567.1 - 4.8e-11 42.3 0.0 2.5e-09 36.6 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18567.1 - 0.00012 21.2 0.0 0.0005 19.2 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA18567.1 - 0.0018 17.3 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA18567.1 - 0.18 10.8 0.0 0.41 9.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DZR PF12773.2 ESA18568.1 - 0.018 14.8 3.5 2.1 8.2 0.4 3.1 3 0 0 3 3 3 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESA18568.1 - 0.13 11.4 9.9 0.68 9.2 2.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain FYVE PF01363.16 ESA18568.1 - 0.4 10.6 6.4 1.8 8.5 0.1 2.8 1 1 1 2 2 2 0 FYVE zinc finger HTH_36 PF13730.1 ESA18569.1 - 0.076 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Pkinase_Tyr PF07714.12 ESA18570.1 - 3.6e-31 108.1 0.0 4.3e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18570.1 - 1.2e-25 90.1 0.0 1.6e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ATG16 PF08614.6 ESA18571.1 - 0.0077 16.0 4.9 0.046 13.5 3.1 1.9 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Macoilin PF09726.4 ESA18571.1 - 0.019 13.2 3.4 0.023 13.0 2.3 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF4200 PF13863.1 ESA18571.1 - 0.023 14.6 4.6 0.038 13.9 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Spc7 PF08317.6 ESA18571.1 - 0.039 12.6 5.7 0.044 12.4 4.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.4 ESA18571.1 - 0.046 12.6 1.9 0.054 12.4 1.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Med2 PF11214.3 ESA18571.1 - 0.086 12.8 2.2 0.15 12.0 0.8 1.9 1 1 1 2 2 2 0 Mediator complex subunit 2 Tropomyosin PF00261.15 ESA18571.1 - 0.098 11.7 6.6 0.24 10.4 4.6 1.4 1 1 0 1 1 1 0 Tropomyosin Uds1 PF15456.1 ESA18571.1 - 0.17 11.8 5.3 0.6 10.1 3.7 1.9 1 1 0 1 1 1 0 Up-regulated During Septation NTR2 PF15458.1 ESA18571.1 - 0.31 10.2 5.3 0.52 9.4 3.6 1.4 1 0 0 1 1 1 0 Nineteen complex-related protein 2 TMPIT PF07851.8 ESA18571.1 - 0.62 9.0 3.2 0.77 8.7 2.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein DivIVA PF05103.8 ESA18571.1 - 0.66 10.0 6.1 1.4 8.9 0.1 2.1 1 1 1 2 2 2 0 DivIVA protein TMF_DNA_bd PF12329.3 ESA18571.1 - 0.92 9.3 14.8 0.22 11.3 5.6 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding zf-C4pol PF14260.1 ESA18571.1 - 0.97 9.4 3.4 2.8 8.0 1.4 2.2 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Kelch_3 PF13415.1 ESA18573.1 - 1.2e-07 31.7 0.7 0.018 15.2 0.1 3.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA18573.1 - 0.0051 16.3 3.0 0.052 13.1 0.3 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.1 ESA18573.1 - 0.0061 16.4 2.0 0.51 10.3 0.0 4.2 5 0 0 5 5 5 1 Kelch motif DUF996 PF06195.8 ESA18573.1 - 0.027 14.4 0.1 0.046 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Trp_oprn_chp PF09534.5 ESA18573.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) IncA PF04156.9 ESA18573.1 - 0.55 9.8 6.6 1.4 8.5 4.5 1.6 1 1 0 1 1 1 0 IncA protein Kelch_4 PF13418.1 ESA18573.1 - 1.7 8.4 7.1 0.86 9.4 0.1 3.5 3 1 1 4 4 4 0 Galactose oxidase, central domain NYN PF01936.13 ESA18574.1 - 2.2e-06 28.0 0.0 3.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 NYN domain DUF904 PF06005.7 ESA18575.1 - 7.6e-05 22.9 1.9 0.00011 22.4 1.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF904) bZIP_2 PF07716.10 ESA18575.1 - 0.0099 15.6 3.5 0.013 15.2 1.9 1.6 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.16 ESA18575.1 - 0.024 14.6 1.8 0.04 13.8 1.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor NAP PF00956.13 ESA18575.1 - 0.028 13.5 0.9 0.032 13.3 0.6 1.1 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) DUF4515 PF14988.1 ESA18575.1 - 0.03 13.9 2.5 0.033 13.8 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) Uso1_p115_C PF04871.8 ESA18575.1 - 0.051 13.5 1.3 0.065 13.1 0.9 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF972 PF06156.8 ESA18575.1 - 0.055 13.8 1.3 0.075 13.3 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DivIC PF04977.10 ESA18575.1 - 1.6 8.2 5.9 3.1 7.3 4.1 1.6 1 1 0 1 1 1 0 Septum formation initiator DASH_Dad4 PF08650.5 ESA18577.1 - 0.19 11.6 6.7 1.3 8.9 0.1 2.3 1 1 1 2 2 2 0 DASH complex subunit Dad4 HWE_HK PF07536.9 ESA18580.1 - 0.031 14.6 0.1 0.058 13.8 0.1 1.4 1 0 0 1 1 1 0 HWE histidine kinase Noc2 PF03715.8 ESA18580.1 - 0.32 9.8 2.5 0.44 9.3 1.8 1.2 1 0 0 1 1 1 0 Noc2p family bZIP_1 PF00170.16 ESA18580.1 - 3.1 7.8 10.7 12 5.9 1.0 3.5 2 1 1 3 3 3 0 bZIP transcription factor DUF972 PF06156.8 ESA18580.1 - 4.3 7.7 7.5 1.3 9.3 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) GRAB PF10375.4 ESA18581.1 - 0.01 15.5 0.1 0.025 14.2 0.1 1.7 1 0 0 1 1 1 0 GRIP-related Arf-binding domain RRP7 PF12923.2 ESA18581.1 - 1.1 9.2 11.5 0.086 12.8 3.0 2.6 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) DUF1268 PF06896.6 ESA18582.1 - 0.011 16.0 3.2 0.036 14.3 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1268) Peptidase_S49_N PF08496.5 ESA18582.1 - 1.3 8.8 5.1 2.5 7.8 3.5 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal OmpH PF03938.9 ESA18583.1 - 0.053 13.4 1.1 0.11 12.4 0.8 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF972 PF06156.8 ESA18583.1 - 2 8.7 6.7 0.57 10.5 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) adh_short PF00106.20 ESA18584.1 - 2e-11 44.0 0.0 2.9e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA18584.1 - 0.00019 21.1 0.0 0.00029 20.5 0.0 1.2 1 0 0 1 1 1 1 KR domain TLD PF07534.11 ESA18586.1 - 7.4e-31 106.9 7.6 1.8e-15 57.1 0.2 3.5 3 1 0 3 3 3 2 TLD BTB PF00651.26 ESA18586.1 - 8.2e-30 103.0 0.9 1e-17 64.1 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA18586.1 - 5.4e-10 39.0 5.7 1.3e-06 28.1 0.1 4.1 2 2 2 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA18586.1 - 0.0068 15.5 0.8 0.1 11.7 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) Latexin PF06907.7 ESA18587.1 - 0.0089 15.2 0.6 0.011 14.9 0.4 1.1 1 0 0 1 1 1 1 Latexin E1_DerP2_DerF2 PF02221.10 ESA18588.1 - 8.9e-08 32.4 1.1 0.00016 21.9 0.1 2.1 1 1 1 2 2 2 2 ML domain CD34_antigen PF06365.7 ESA18590.1 - 0.1 12.2 0.2 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF3981 PF13139.1 ESA18593.1 - 3.7 7.5 6.7 7.8 6.5 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3981) Pkinase PF00069.20 ESA18596.1 - 1.9e-08 33.8 0.0 2.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18596.1 - 1.7e-07 30.5 0.0 2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4007 PF13182.1 ESA18597.1 - 0.022 13.5 0.8 0.024 13.4 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4007) LemA PF04011.7 ESA18597.1 - 0.077 12.0 0.1 0.083 11.9 0.1 1.2 1 0 0 1 1 1 0 LemA family Ig_Tie2_1 PF10430.4 ESA18597.1 - 0.077 13.3 0.0 0.092 13.1 0.0 1.1 1 0 0 1 1 1 0 Tie-2 Ig-like domain 1 PMR5N PF14416.1 ESA18597.1 - 0.23 11.5 1.1 15 5.6 0.0 2.3 2 0 0 2 2 2 0 PMR5 N terminal Domain Asp_Arg_Hydrox PF05118.10 ESA18598.1 - 0.059 13.2 0.1 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Aspartyl/Asparaginyl beta-hydroxylase DUF4413 PF14372.1 ESA18599.1 - 0.00027 20.8 0.1 0.00034 20.5 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4413) Lipase_3 PF01764.20 ESA18601.1 - 5e-34 116.9 0.0 7.6e-34 116.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.3 ESA18601.1 - 0.0021 17.4 0.0 0.0049 16.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.2 ESA18601.1 - 0.0047 16.6 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 ESA18601.1 - 0.0047 16.2 0.0 0.0068 15.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 ESA18601.1 - 0.0065 16.3 0.0 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.15 ESA18601.1 - 0.048 13.8 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 ESA18601.1 - 0.16 11.4 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DNA_topoisoIV PF00521.15 ESA18602.1 - 4.7e-119 398.0 0.2 4.7e-119 398.0 0.1 2.0 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 ESA18602.1 - 2.8e-32 111.3 4.5 1e-31 109.4 3.1 2.1 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 ESA18602.1 - 2e-13 50.1 0.0 2e-12 46.9 0.0 2.8 2 0 0 2 2 2 1 Toprim domain HATPase_c PF02518.21 ESA18602.1 - 8.5e-08 31.8 0.0 3.5e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Gag_MA PF01140.14 ESA18603.1 - 0.096 12.5 0.6 0.28 11.0 0.1 1.8 2 0 0 2 2 2 0 Matrix protein (MA), p15 DUF2701 PF10857.3 ESA18603.1 - 0.17 11.7 1.9 2.2 8.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2701) SLAC1 PF03595.12 ESA18606.1 - 0.0046 15.6 0.1 0.0053 15.4 0.1 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel ABC2_membrane_3 PF12698.2 ESA18606.1 - 0.012 14.6 8.7 0.29 10.1 3.1 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Sigma_reg_N PF13800.1 ESA18606.1 - 0.036 14.1 0.5 0.036 14.1 0.3 1.8 1 1 1 2 2 2 0 Sigma factor regulator N-terminal Big_5 PF13205.1 ESA18606.1 - 0.12 13.0 0.3 0.17 12.5 0.2 1.2 1 0 0 1 1 1 0 Bacterial Ig-like domain F-box-like PF12937.2 ESA18607.1 - 1.8e-09 37.1 0.3 3e-09 36.4 0.2 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA18607.1 - 0.0017 17.9 0.2 0.0055 16.3 0.2 1.9 1 1 0 1 1 1 1 F-box domain PRO8NT PF08082.6 ESA18607.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain TLD PF07534.11 ESA18608.1 - 2.7e-09 37.1 0.2 2.7e-09 37.1 0.1 2.2 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA18608.1 - 3.4e-08 33.4 0.0 7.2e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA18608.1 - 3.2e-06 26.9 1.9 2.3e-05 24.1 0.1 3.0 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA18609.1 - 3e-07 30.5 1.4 7.5e-07 29.2 1.0 1.6 1 1 0 1 1 1 1 TLD Uma2 PF05685.7 ESA18610.1 - 1.1e-06 28.1 0.0 1.9e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 Putative restriction endonuclease DTHCT PF08070.6 ESA18614.1 - 0.18 12.4 4.6 1.1 9.9 0.5 2.7 2 0 0 2 2 2 0 DTHCT (NUC029) region Perm-CXXC PF15629.1 ESA18617.1 - 0.034 14.1 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Permuted single zf-CXXC unit CENP-I PF07778.6 ESA18617.1 - 0.093 10.9 0.0 0.093 10.9 0.0 1.0 1 0 0 1 1 1 0 Mis6 DUF544 PF04424.8 ESA18618.1 - 0.085 12.6 0.7 0.13 12.0 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF544) DUF2569 PF10754.4 ESA18620.1 - 0.17 12.0 1.1 0.23 11.6 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) Pkinase PF00069.20 ESA18622.1 - 1.1e-27 96.8 0.1 1.3e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18622.1 - 5.3e-27 94.5 0.0 5.8e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18622.1 - 0.053 13.2 0.1 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family ABC2_membrane_5 PF13346.1 ESA18624.1 - 0.046 13.0 2.3 0.053 12.7 1.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein R3H PF01424.17 ESA18624.1 - 0.095 12.4 0.0 2.1 8.1 0.0 2.1 2 0 0 2 2 2 0 R3H domain Glyco_transf_22 PF03901.12 ESA18625.1 - 8e-10 38.2 2.6 8.9e-10 38.1 1.8 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Fungal_trans PF04082.13 ESA18627.1 - 1.4e-28 99.4 1.3 2.8e-28 98.5 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 ESA18627.1 - 3.3e-11 42.8 9.2 6.6e-11 41.9 6.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkip-1 PF06878.6 ESA18628.1 - 0.034 14.0 1.1 0.043 13.6 0.8 1.2 1 0 0 1 1 1 0 Pkip-1 protein DUF4297 PF14130.1 ESA18628.1 - 0.1 12.5 4.5 0.12 12.3 3.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4297) Toxin_64 PF15542.1 ESA18628.1 - 0.18 12.3 4.3 0.25 11.9 3.0 1.2 1 0 0 1 1 1 0 Putative toxin 64 MARVEL PF01284.18 ESA18629.1 - 0.00012 21.8 0.8 0.00024 20.9 0.6 1.5 1 0 0 1 1 1 1 Membrane-associating domain UPF0542 PF15086.1 ESA18629.1 - 0.086 12.5 0.1 0.086 12.5 0.1 2.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 DUF4198 PF10670.4 ESA18631.1 - 0.85 9.5 5.9 1 9.3 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Mito_fiss_reg PF05308.6 ESA18633.1 - 0.43 9.9 9.7 0.46 9.8 6.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator BTB PF00651.26 ESA18636.1 - 6.9e-19 67.8 0.6 6.9e-19 67.8 0.4 2.5 2 1 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA18636.1 - 2.5e-11 43.7 2.8 3.1e-11 43.4 0.2 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA18636.1 - 0.00029 20.6 0.6 0.0021 17.8 0.1 2.7 2 1 0 2 2 2 1 BTB And C-terminal Kelch Sel1 PF08238.7 ESA18638.1 - 5.8e-53 176.1 8.3 1.2e-12 47.9 0.2 5.2 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA18638.1 - 0.0065 16.8 7.8 18 6.0 0.0 5.3 5 1 0 5 5 5 2 Tetratricopeptide repeat EF-hand_10 PF14788.1 ESA18638.1 - 0.0091 15.6 0.3 46 3.7 0.0 3.8 4 0 0 4 4 4 0 EF hand TPR_11 PF13414.1 ESA18638.1 - 0.083 12.5 14.8 7.5 6.2 2.4 4.4 1 1 5 6 6 6 0 TPR repeat TFIIB PF00382.14 ESA18638.1 - 0.29 10.9 1.3 14 5.5 0.0 3.6 4 1 1 5 5 5 0 Transcription factor TFIIB repeat MIT PF04212.13 ESA18638.1 - 3.3 7.6 15.5 11 5.9 2.9 4.0 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA18638.1 - 5 6.9 6.6 14 5.5 0.3 3.7 3 1 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation Pcc1 PF09341.5 ESA18640.1 - 5.8e-21 74.3 0.1 6.3e-21 74.2 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 HSP20 PF00011.16 ESA18641.1 - 1.7e-11 43.9 3.9 4e-11 42.6 2.7 1.6 1 1 0 1 1 1 1 Hsp20/alpha crystallin family HSP70 PF00012.15 ESA18641.1 - 0.0052 14.7 0.9 0.0057 14.6 0.6 1.1 1 0 0 1 1 1 1 Hsp70 protein EssA PF10661.4 ESA18641.1 - 2.1 8.0 7.8 0.8 9.3 3.2 1.7 1 1 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA LANC_like PF05147.8 ESA18642.1 - 4e-58 196.6 1.2 5.8e-58 196.1 0.8 1.2 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.8 ESA18642.1 - 0.00014 21.0 0.7 0.011 14.8 0.1 2.8 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.8 ESA18642.1 - 0.0016 17.7 3.8 0.34 10.1 0.1 3.1 2 1 0 3 3 3 2 D-glucuronyl C5-epimerase C-terminus DUF1680 PF07944.7 ESA18642.1 - 0.0033 15.7 0.0 0.0063 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) Thioredox_DsbH PF03190.10 ESA18644.1 - 1.5e-75 252.3 0.0 2.9e-75 251.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.1 ESA18644.1 - 3.6e-12 46.1 0.0 1.1e-11 44.6 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_76 PF03663.9 ESA18644.1 - 3.4e-06 26.7 0.2 0.001 18.5 0.0 2.6 2 1 0 2 2 2 2 Glycosyl hydrolase family 76 C5-epim_C PF06662.8 ESA18644.1 - 5e-06 25.9 0.8 0.014 14.6 0.0 3.0 3 0 0 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.8 ESA18644.1 - 4.7e-05 22.5 2.2 0.0026 16.8 0.1 2.5 2 0 0 2 2 2 2 Glycosyl Hydrolase Family 88 DUF1680 PF07944.7 ESA18644.1 - 0.0001 20.7 0.6 0.0043 15.3 0.0 2.7 2 1 0 2 2 2 1 Putative glycosyl hydrolase of unknown function (DUF1680) GlcNAc_2-epim PF07221.6 ESA18644.1 - 0.00034 19.7 0.0 0.077 11.9 0.0 2.4 2 0 0 2 2 2 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Thioredoxin_2 PF13098.1 ESA18644.1 - 0.011 15.9 0.0 0.035 14.2 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like domain Ribonuc_L-PSP PF01042.16 ESA18645.1 - 5.6e-28 97.1 0.0 8.4e-28 96.5 0.0 1.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP DUF2365 PF10157.4 ESA18645.1 - 0.083 12.7 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) Leader_Thr PF08254.6 ESA18646.1 - 0.12 12.0 5.6 4.6 7.0 0.1 3.4 4 0 0 4 4 4 0 Threonine leader peptide DUF1856 PF08983.5 ESA18646.1 - 7.5 6.7 10.5 17 5.5 2.1 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1856) zf-RanBP PF00641.13 ESA18646.1 - 8.8 5.5 7.4 56 2.9 0.1 3.8 5 0 0 5 5 5 0 Zn-finger in Ran binding protein and others Thiolase_C PF02803.13 ESA18647.1 - 5.7e-13 48.3 0.0 2.5e-12 46.3 0.0 1.9 1 1 1 2 2 2 1 Thiolase, C-terminal domain Ketoacyl-synt_C PF02801.17 ESA18647.1 - 0.00027 20.7 0.0 0.0085 15.9 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain tRNA-synt_1f PF01921.13 ESA18648.1 - 0.17 10.5 2.4 0.22 10.1 1.7 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) DUF4066 PF13278.1 ESA18650.1 - 6.3e-30 103.6 0.0 8.2e-30 103.2 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase DJ-1_PfpI PF01965.19 ESA18650.1 - 6e-16 58.2 0.0 8.6e-16 57.7 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_5 PF13507.1 ESA18650.1 - 0.014 14.3 0.0 0.091 11.6 0.0 1.9 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 ESA18650.1 - 0.035 13.5 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I GATase_3 PF07685.9 ESA18650.1 - 0.049 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Pkinase_Tyr PF07714.12 ESA18651.1 - 4.9e-89 297.8 0.2 3e-44 151.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA18651.1 - 9.8e-73 244.4 4.0 7.9e-36 123.5 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.17 ESA18651.1 - 2.3e-05 23.8 0.8 0.00031 20.1 0.1 2.5 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA18651.1 - 6.1e-05 22.1 0.7 0.045 12.8 0.2 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA18651.1 - 0.00077 19.2 0.1 0.54 9.9 0.1 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Oxidored_FMN PF00724.15 ESA18655.1 - 4.4e-83 279.0 0.0 5.6e-83 278.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.19 ESA18655.1 - 0.092 12.0 0.0 0.59 9.3 0.0 2.1 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel Sel1 PF08238.7 ESA18656.1 - 2.3e-40 136.1 10.0 4.8e-11 42.9 0.2 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ESA18656.1 - 0.0016 18.7 5.8 8.4 7.0 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA18656.1 - 0.0076 15.8 9.9 0.081 12.5 1.7 2.6 1 1 0 2 2 2 2 TPR repeat NAPRTase PF04095.11 ESA18656.1 - 0.015 14.5 0.1 0.094 11.9 0.0 2.2 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) family TPR_7 PF13176.1 ESA18656.1 - 0.26 11.1 1.6 3.1 7.8 0.1 3.1 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA18656.1 - 0.34 10.5 15.4 2.3 7.9 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.13 ESA18656.1 - 0.49 10.3 10.3 21 5.0 1.9 3.8 1 1 2 3 3 3 0 MIT (microtubule interacting and transport) domain DIOX_N PF14226.1 ESA18657.1 - 4.4e-08 33.6 0.0 7.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal KilA-N PF04383.8 ESA18658.1 - 0.027 14.0 0.0 0.73 9.4 0.0 2.3 1 1 0 1 1 1 0 KilA-N domain HAMP PF00672.20 ESA18659.1 - 6.5e-83 272.9 8.1 1.7e-08 34.5 0.0 11.2 10 0 0 10 10 10 10 HAMP domain HATPase_c PF02518.21 ESA18659.1 - 4e-30 103.7 1.9 9.1e-30 102.6 0.2 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 ESA18659.1 - 1.6e-26 92.5 1.0 1.5e-24 86.1 0.2 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 ESA18659.1 - 1.6e-18 66.4 0.6 1.9e-17 62.9 0.4 3.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GatB_Yqey PF02637.13 ESA18659.1 - 4.5e-12 45.9 22.4 0.37 10.4 0.1 8.5 7 1 1 8 8 8 5 GatB domain PilJ PF13675.1 ESA18659.1 - 5.4e-06 26.7 2.0 4 7.7 0.0 6.8 6 1 0 7 7 7 1 Type IV pili methyl-accepting chemotaxis transducer N-term VBS PF08913.5 ESA18659.1 - 8.2e-06 26.0 31.7 2.3 8.4 0.1 9.0 7 2 2 9 9 9 4 Vinculin Binding Site HMG_box PF00505.14 ESA18659.1 - 0.0016 18.6 0.8 30 4.9 0.0 5.2 6 0 0 6 6 6 0 HMG (high mobility group) box Abhydrolase_8 PF06259.7 ESA18659.1 - 0.044 13.2 39.9 1.3 8.5 0.3 8.1 4 4 4 8 8 8 0 Alpha/beta hydrolase Pox_A_type_inc PF04508.7 ESA18659.1 - 0.11 12.2 2.2 3.8 7.5 0.0 4.3 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat OspD PF03207.8 ESA18659.1 - 0.14 11.2 53.7 1.3 8.1 1.5 7.7 1 1 2 7 7 7 0 Borrelia outer surface protein D (OspD) IL32 PF15225.1 ESA18659.1 - 0.16 11.9 2.0 1.7e+02 2.2 0.0 5.8 8 0 0 8 8 8 0 Interleukin 32 AcylCoA_dehyd_C PF12186.3 ESA18659.1 - 0.5 10.2 23.5 12 5.8 0.1 9.6 10 1 0 10 10 9 0 Acyl-CoA dehydrogenase C terminal DUF1759 PF03564.10 ESA18659.1 - 2 8.2 13.0 20 4.9 0.0 7.0 8 1 0 8 8 8 0 Protein of unknown function (DUF1759) NGF PF00243.13 ESA18659.1 - 2.2 8.0 23.8 15 5.3 0.6 7.4 4 4 4 8 8 8 0 Nerve growth factor family DUF883 PF05957.8 ESA18659.1 - 3.3 8.1 22.4 23 5.4 0.1 8.0 8 2 3 11 11 11 0 Bacterial protein of unknown function (DUF883) DUF2365 PF10157.4 ESA18659.1 - 3.6 7.4 34.8 21 4.9 0.1 11.0 6 4 5 13 13 13 0 Uncharacterized conserved protein (DUF2365) CHDCT2 PF08074.6 ESA18659.1 - 9.5 5.9 8.3 4.8 6.8 0.1 4.3 4 2 1 6 6 6 0 CHDCT2 (NUC038) domain TP6A_N PF04406.9 ESA18660.1 - 2.6e-16 59.0 0.2 4.4e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase UpxZ PF06603.6 ESA18660.1 - 0.0054 16.7 0.1 0.012 15.5 0.1 1.6 1 0 0 1 1 1 1 UpxZ family of transcription anti-terminator antagonists His_Phos_2 PF00328.17 ESA18661.1 - 2.4e-32 112.6 0.3 3.5e-32 112.1 0.2 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Dynamin_M PF01031.15 ESA18661.1 - 0.038 12.7 0.1 0.065 12.0 0.1 1.3 1 0 0 1 1 1 0 Dynamin central region RRM_1 PF00076.17 ESA18662.1 - 1.7e-62 206.9 7.5 3.6e-17 61.7 0.0 7.2 7 0 0 7 7 7 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18662.1 - 3.5e-48 161.4 4.2 1.5e-13 50.5 0.0 7.3 7 0 0 7 7 7 6 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18662.1 - 8e-33 112.0 1.3 8.4e-10 38.3 0.0 6.0 6 0 0 6 6 6 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA18662.1 - 4.4e-07 29.5 0.1 0.044 13.5 0.0 3.2 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif DAO PF01266.19 ESA18663.1 - 7.6e-53 179.6 0.0 1.1e-52 179.1 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 ESA18663.1 - 3.7e-10 39.2 3.7 1.3e-09 37.4 1.7 2.2 2 1 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.2 ESA18663.1 - 1.8e-07 30.6 0.2 4.1e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESA18663.1 - 2.6e-05 24.1 0.0 0.00034 20.5 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 ESA18663.1 - 0.00022 20.2 0.6 0.0012 17.7 0.0 2.2 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESA18663.1 - 0.0013 18.6 0.9 0.0039 17.1 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 ESA18663.1 - 0.0015 17.6 0.1 0.036 13.1 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 ESA18663.1 - 0.0018 16.8 0.1 0.011 14.2 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein EF-hand_7 PF13499.1 ESA18663.1 - 0.0047 17.0 0.2 0.013 15.5 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 ESA18663.1 - 0.0051 16.0 2.4 0.35 10.2 0.0 2.9 2 0 0 2 2 2 1 EF hand 3HCDH_N PF02737.13 ESA18663.1 - 0.01 15.5 0.0 0.027 14.1 0.0 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 ESA18663.1 - 0.016 15.5 0.1 0.048 14.0 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_6 PF13405.1 ESA18663.1 - 0.025 14.4 0.4 0.49 10.4 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain Thi4 PF01946.12 ESA18663.1 - 0.045 12.8 0.7 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.7 ESA18663.1 - 0.063 12.1 0.1 0.83 8.5 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_10 PF13460.1 ESA18663.1 - 0.081 12.9 0.5 0.42 10.6 0.1 2.1 2 0 0 2 2 2 0 NADH(P)-binding EF-hand_8 PF13833.1 ESA18663.1 - 0.13 11.8 0.9 0.7 9.5 0.2 2.4 2 1 0 2 2 2 0 EF-hand domain pair Methyltransf_31 PF13847.1 ESA18667.1 - 8.6e-14 51.3 0.0 1.8e-13 50.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18667.1 - 2.1e-12 47.0 0.0 3.1e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA18667.1 - 6.8e-10 39.3 0.0 2.6e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA18667.1 - 5.9e-09 36.3 0.0 1.7e-08 34.8 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18667.1 - 5.3e-08 33.1 0.0 1.5e-07 31.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18667.1 - 1.6e-07 31.9 0.0 4.6e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA18667.1 - 0.00018 20.6 0.1 0.0028 16.7 0.0 2.5 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA18667.1 - 0.0004 20.4 0.0 0.00094 19.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18667.1 - 0.00065 18.8 0.0 0.0014 17.7 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.13 ESA18667.1 - 0.0037 16.4 0.0 0.0067 15.6 0.0 1.4 2 0 0 2 2 2 1 O-methyltransferase CheR PF01739.13 ESA18667.1 - 0.063 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain PBP1_TM PF14812.1 ESA18670.1 - 0.21 11.8 2.0 0.84 9.9 1.7 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CAF1 PF04857.15 ESA18671.1 - 6.7e-68 228.8 0.0 1.1e-67 228.1 0.0 1.3 1 1 0 1 1 1 1 CAF1 family ribonuclease NIF3 PF01784.13 ESA18672.1 - 2.6e-62 210.5 0.0 3.1e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Pkinase_Tyr PF07714.12 ESA18673.1 - 1.3e-36 125.9 0.0 1.5e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18673.1 - 6.3e-36 123.8 0.1 7.5e-36 123.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA18673.1 - 0.00075 18.6 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA18673.1 - 0.0011 18.2 0.1 0.0016 17.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA18673.1 - 0.0053 16.5 0.0 0.011 15.4 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA18673.1 - 0.034 13.4 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 ESA18673.1 - 0.042 13.1 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TLD PF07534.11 ESA18675.1 - 6.4e-05 22.9 7.0 0.00038 20.4 4.9 1.9 1 1 0 1 1 1 1 TLD TIR_2 PF13676.1 ESA18679.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 TIR domain Polysacc_deac_1 PF01522.16 ESA18681.1 - 2.3e-32 111.2 0.2 5.9e-32 109.9 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA18681.1 - 0.0054 15.6 0.0 0.0072 15.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Alg14 PF08660.6 ESA18682.1 - 8.5e-20 71.4 0.3 9.3e-20 71.3 0.2 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like DUF3963 PF13124.1 ESA18683.1 - 0.029 14.1 0.2 0.053 13.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) F-box-like PF12937.2 ESA18685.1 - 0.0025 17.5 1.6 0.0025 17.5 1.1 2.1 2 0 0 2 2 2 1 F-box-like Peptidase_S10 PF00450.17 ESA18687.1 - 8.8e-70 235.9 2.2 1.1e-69 235.6 1.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Ion_trans PF00520.26 ESA18691.1 - 6.8e-07 28.7 20.8 2.1e-06 27.1 7.1 2.5 1 1 0 2 2 2 2 Ion transport protein DUF912 PF06024.7 ESA18691.1 - 2 8.5 10.7 0.38 10.8 1.4 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Glyoxalase PF00903.20 ESA18694.1 - 0.0012 18.7 0.0 0.032 14.2 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DinB_2 PF12867.2 ESA18694.1 - 0.099 12.9 2.1 2.3 8.5 0.1 2.4 2 0 0 2 2 2 0 DinB superfamily PRAP PF15314.1 ESA18694.1 - 0.22 11.8 0.9 13 6.1 0.0 2.6 3 0 0 3 3 3 0 Proline-rich acidic protein 1, pregnancy-specific uterine IncA PF04156.9 ESA18696.1 - 0.67 9.5 8.4 6.2 6.3 0.0 2.4 2 0 0 2 2 2 0 IncA protein Egg_lysin PF01303.12 ESA18699.1 - 0.11 12.5 0.4 0.33 10.9 0.3 1.9 1 1 0 1 1 1 0 Egg lysin (Sperm-lysin) OATP PF03137.15 ESA18699.1 - 0.27 9.2 3.2 0.21 9.5 1.5 1.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.14 ESA18699.1 - 0.42 8.4 5.6 0.48 8.2 3.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PGBA_C PF15437.1 ESA18699.1 - 4.2 7.5 12.0 0.51 10.5 2.7 2.4 1 1 1 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Dimer_Tnp_hAT PF05699.9 ESA18700.1 - 1.7e-05 24.3 0.0 0.00013 21.5 0.0 2.2 1 1 1 2 2 2 1 hAT family C-terminal dimerisation region LAMTOR PF15454.1 ESA18702.1 - 2.3e-09 37.3 1.2 2.3e-09 37.3 0.8 1.9 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF4443 PF14544.1 ESA18702.1 - 0.0083 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) DUF1654 PF07867.6 ESA18702.1 - 0.044 13.1 0.2 0.092 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) KSR1-SAM PF13543.1 ESA18702.1 - 0.06 13.1 0.3 0.06 13.1 0.2 1.5 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 Ipi1_N PF12333.3 ESA18702.1 - 0.14 12.1 0.9 1.2 9.1 0.7 2.1 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Med30 PF11315.3 ESA18702.1 - 1.7 8.7 5.7 6.1 6.9 3.9 2.0 1 1 0 1 1 1 0 Mediator complex subunit 30 DUF2809 PF10990.3 ESA18703.1 - 6.4 7.2 7.9 10 6.5 5.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2809) Pkinase_Tyr PF07714.12 ESA18704.1 - 8.4e-25 87.3 0.0 1.4e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18704.1 - 2e-21 76.3 0.0 3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA18704.1 - 1.1e-18 67.2 30.7 1.2e-06 28.9 1.2 6.2 7 0 0 7 7 7 3 Sel1 repeat TPR_19 PF14559.1 ESA18704.1 - 0.0021 18.3 9.5 0.11 12.8 0.2 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat RE_AlwI PF09491.5 ESA18704.1 - 0.0032 16.0 1.4 0.63 8.4 0.0 2.6 3 0 0 3 3 3 2 AlwI restriction endonuclease TPR_14 PF13428.1 ESA18704.1 - 0.05 14.2 2.7 3 8.7 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18704.1 - 0.073 13.5 19.4 2.7 8.6 0.7 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA18704.1 - 0.44 10.2 22.3 0.17 11.5 0.2 5.1 4 1 1 5 5 5 0 TPR repeat TPR_16 PF13432.1 ESA18704.1 - 3.9 8.2 9.3 24 5.7 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA18704.1 - 9.5 6.7 10.3 0.44 10.8 0.1 3.8 4 2 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA18705.1 - 1.1e-33 116.5 0.4 2.7e-33 115.2 0.3 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18705.1 - 1.2e-33 116.3 0.1 2.4e-33 115.3 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA18705.1 - 7e-06 26.5 2.3 7e-06 26.5 1.6 2.0 3 0 0 3 3 3 1 Sel1 repeat SPOUT_MTase_2 PF14419.1 ESA18705.1 - 0.0074 15.4 0.3 0.028 13.6 0.1 2.0 2 0 0 2 2 2 1 AF2226-like SPOUT RNA Methylase fused to THUMP DUF972 PF06156.8 ESA18705.1 - 0.12 12.7 10.2 0.17 12.2 2.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TPR_19 PF14559.1 ESA18705.1 - 0.13 12.6 1.2 0.51 10.7 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_32 PF13654.1 ESA18706.1 - 0.016 13.8 1.8 0.016 13.8 1.2 1.2 1 0 0 1 1 1 0 AAA domain Rootletin PF15035.1 ESA18706.1 - 0.049 13.5 8.7 0.028 14.3 4.2 1.7 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF4430 PF14478.1 ESA18706.1 - 0.05 13.6 0.8 0.19 11.7 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4430) DUF2730 PF10805.3 ESA18706.1 - 0.096 12.4 0.6 0.39 10.4 0.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) Uds1 PF15456.1 ESA18706.1 - 1.3 8.9 7.8 0.49 10.3 2.8 1.9 2 0 0 2 2 2 0 Up-regulated During Septation eIF3_N PF09440.5 ESA18706.1 - 2.4 8.3 8.2 0.93 9.6 1.3 2.4 1 1 2 3 3 3 0 eIF3 subunit 6 N terminal domain DUF1664 PF07889.7 ESA18706.1 - 9.5 6.0 7.3 4.1 7.2 0.9 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Sel1 PF08238.7 ESA18707.1 - 2.1e-59 196.6 48.3 2.4e-09 37.5 0.0 11.7 11 1 0 11 11 11 8 Sel1 repeat TPR_11 PF13414.1 ESA18707.1 - 0.078 12.6 30.6 0.34 10.5 0.1 6.6 3 3 2 6 6 6 0 TPR repeat TPR_6 PF13174.1 ESA18707.1 - 0.44 11.1 21.4 2.1 8.9 0.1 8.3 10 0 0 10 10 10 0 Tetratricopeptide repeat DUF1912 PF08930.5 ESA18710.1 - 0.12 12.4 0.4 0.21 11.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) SAM_PNT PF02198.11 ESA18711.1 - 0.0019 17.9 0.1 0.0035 17.0 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.12 ESA18711.1 - 0.0051 16.6 0.1 0.038 13.8 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA18711.1 - 0.067 13.3 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MatP PF06303.7 ESA18711.1 - 0.15 12.0 1.5 2.4 8.0 0.2 2.1 1 1 0 2 2 2 0 Organiser of macrodomain of Terminus of chromosome VWA_2 PF13519.1 ESA18712.1 - 1.7e-06 28.2 0.0 4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA18712.1 - 0.0045 16.7 0.0 0.0094 15.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Erg28 PF03694.8 ESA18713.1 - 2.5e-40 136.9 8.4 2.8e-40 136.7 5.9 1.0 1 0 0 1 1 1 1 Erg28 like protein DUF308 PF03729.8 ESA18713.1 - 0.5 10.3 9.8 0.22 11.5 2.5 2.6 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) DUF4149 PF13664.1 ESA18713.1 - 8.5 6.4 9.4 6.4 6.8 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) FixO PF02433.10 ESA18714.1 - 0.0077 15.6 0.4 0.0077 15.6 0.3 1.4 2 0 0 2 2 2 1 Cytochrome C oxidase, mono-heme subunit/FixO AAA_11 PF13086.1 ESA18714.1 - 2.5 7.6 6.8 3.3 7.2 4.7 1.2 1 0 0 1 1 1 0 AAA domain AcetylCoA_hyd_C PF13336.1 ESA18715.1 - 1e-39 135.6 0.0 1.7e-39 134.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.10 ESA18715.1 - 2.2e-37 128.7 0.0 3.3e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain CitF PF04223.7 ESA18715.1 - 0.0062 15.2 0.0 3.2 6.3 0.0 2.6 3 0 0 3 3 3 2 Citrate lyase, alpha subunit (CitF) SET PF00856.23 ESA18716.1 - 0.0001 22.6 3.4 0.00086 19.6 0.0 3.4 3 1 0 3 3 3 1 SET domain Neisseria_TspB PF05616.8 ESA18716.1 - 0.001 17.5 15.1 0.0019 16.6 10.5 1.3 1 0 0 1 1 1 1 Neisseria meningitidis TspB protein Trypan_PARP PF05887.6 ESA18716.1 - 0.0032 17.2 3.0 0.0032 17.2 2.1 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.9 ESA18716.1 - 0.03 12.3 9.1 0.058 11.4 6.3 1.4 1 0 0 1 1 1 0 CDC45-like protein Zn_clus PF00172.13 ESA18716.1 - 0.45 10.4 9.1 1.1 9.1 5.1 2.5 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PC4 PF02229.11 ESA18717.1 - 5.1e-23 80.0 1.6 9.6e-23 79.1 1.1 1.5 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) BSP_II PF05432.6 ESA18717.1 - 0.062 12.5 8.9 0.065 12.4 6.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PRP1_N PF06424.7 ESA18717.1 - 0.13 12.5 14.7 0.033 14.5 8.0 1.5 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Spt5_N PF11942.3 ESA18717.1 - 0.4 11.3 17.2 0.38 11.4 11.0 1.7 1 1 1 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Bravo_FIGEY PF13882.1 ESA18717.1 - 0.59 11.0 13.7 1 10.3 9.5 1.4 1 0 0 1 1 1 0 Bravo-like intracellular region CDC45 PF02724.9 ESA18717.1 - 1.3 6.9 13.5 1.4 6.8 9.4 1.1 1 0 0 1 1 1 0 CDC45-like protein VID27 PF08553.5 ESA18717.1 - 1.4 7.0 13.2 1.5 6.9 9.2 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein EMP24_GP25L PF01105.19 ESA18718.1 - 7.1e-50 169.2 0.0 1.1e-49 168.6 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Anp1 PF03452.9 ESA18718.1 - 0.0041 16.2 0.0 0.0059 15.7 0.0 1.2 1 0 0 1 1 1 1 Anp1 DUF904 PF06005.7 ESA18718.1 - 0.095 13.0 0.9 0.16 12.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF904) FTH PF01827.22 ESA18721.1 - 0.0033 17.0 3.4 0.023 14.3 0.1 2.5 2 1 1 3 3 3 2 FTH domain Myb_DNA-bind_4 PF13837.1 ESA18722.1 - 7.4e-12 45.2 0.1 9.2e-12 44.9 0.1 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.4 ESA18722.1 - 0.01 15.9 0.5 0.021 15.0 0.2 1.6 1 1 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_3 PF12776.2 ESA18722.1 - 0.015 15.9 0.8 0.023 15.3 0.5 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF4070 PF13282.1 ESA18722.1 - 0.058 12.9 0.3 0.058 12.9 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4070) Myb_DNA-bind_6 PF13921.1 ESA18722.1 - 0.18 11.9 1.2 0.27 11.3 0.8 1.5 1 1 0 1 1 1 0 Myb-like DNA-binding domain Transposase_21 PF02992.9 ESA18723.1 - 3.3e-09 36.1 0.0 4.7e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Transposase family tnp2 Pkinase_Tyr PF07714.12 ESA18724.1 - 0.00023 20.3 0.0 0.00033 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HMG_box PF00505.14 ESA18725.1 - 5e-10 39.4 0.1 1e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18725.1 - 0.00063 20.0 0.1 0.0036 17.6 0.1 2.0 2 0 0 2 2 2 1 HMG-box domain zf-B_box PF00643.19 ESA18726.1 - 0.43 10.5 4.8 0.84 9.5 3.3 1.5 1 0 0 1 1 1 0 B-box zinc finger Spt5-NGN PF03439.8 ESA18728.1 - 0.012 15.3 0.1 0.18 11.5 0.1 2.8 2 0 0 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section FSH1 PF03959.8 ESA18728.1 - 0.054 12.9 0.1 0.18 11.1 0.1 1.9 1 0 0 1 1 1 0 Serine hydrolase (FSH1) VWA_3 PF13768.1 ESA18729.1 - 1.1e-27 96.6 0.0 1.7e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 ESA18729.1 - 2e-19 69.4 1.1 4.6e-19 68.2 0.8 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.1 ESA18729.1 - 3.9e-16 59.6 0.0 7.3e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA18729.1 - 2.6e-15 56.6 0.2 4.4e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESA18729.1 - 2.6e-05 23.5 0.0 5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2828 PF11443.3 ESA18729.1 - 0.00015 20.1 0.1 0.00025 19.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) vWA-TerF-like PF10138.4 ESA18729.1 - 0.00079 19.3 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Luciferase_N PF05295.6 ESA18729.1 - 0.037 13.8 0.0 0.14 11.9 0.0 2.0 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain VWA_CoxE PF05762.9 ESA18729.1 - 0.2 10.7 0.1 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein TLD PF07534.11 ESA18731.1 - 0.012 15.5 0.1 0.021 14.8 0.0 1.5 2 0 0 2 2 2 0 TLD LRR_6 PF13516.1 ESA18732.1 - 0.13 12.4 2.4 1.5 9.1 0.0 2.8 3 1 0 3 3 3 0 Leucine Rich repeat Vel1p PF10339.4 ESA18733.1 - 0.042 13.0 0.0 0.048 12.8 0.0 1.0 1 0 0 1 1 1 0 Yeast-specific zinc responsive Kelch_4 PF13418.1 ESA18734.1 - 5.2e-12 45.3 3.6 0.015 15.0 0.1 5.0 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA18734.1 - 9.5e-09 35.0 3.9 0.065 13.4 0.0 4.9 4 1 1 5 5 5 2 Kelch motif Kelch_5 PF13854.1 ESA18734.1 - 3.3e-06 26.9 0.1 1.2 9.1 0.0 4.5 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA18734.1 - 4.1e-06 26.8 1.3 0.25 11.5 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA18734.1 - 9.2e-06 25.2 0.1 3.2 7.6 0.0 3.9 4 0 0 4 4 4 3 Kelch motif ETRAMP PF09716.5 ESA18734.1 - 0.16 11.9 0.3 0.28 11.1 0.2 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Kelch_1 PF01344.20 ESA18734.1 - 0.26 10.8 9.5 9.2 5.9 0.0 4.7 5 1 0 5 5 5 0 Kelch motif DUF745 PF05335.8 ESA18739.1 - 0.0029 17.1 5.6 0.0039 16.7 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF745) DivIVA PF05103.8 ESA18739.1 - 0.0059 16.6 11.3 0.018 15.1 5.8 2.2 1 1 1 2 2 2 2 DivIVA protein FliJ PF02050.11 ESA18739.1 - 0.008 16.2 10.2 0.54 10.3 4.4 2.4 2 1 0 2 2 2 2 Flagellar FliJ protein Tropomyosin_1 PF12718.2 ESA18739.1 - 0.035 13.9 14.1 0.041 13.7 7.5 2.0 2 0 0 2 2 2 0 Tropomyosin like DUF4478 PF14793.1 ESA18739.1 - 0.091 12.3 0.2 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4478) DUF3450 PF11932.3 ESA18739.1 - 0.15 11.2 4.5 0.26 10.5 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4472 PF14739.1 ESA18739.1 - 0.17 12.3 6.6 0.37 11.2 4.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4472) Laminin_II PF06009.7 ESA18739.1 - 0.2 11.4 5.6 0.21 11.3 2.9 1.9 1 1 1 2 2 2 0 Laminin Domain II AAA_13 PF13166.1 ESA18739.1 - 0.21 9.9 9.1 0.23 9.8 6.3 1.1 1 0 0 1 1 1 0 AAA domain DUF445 PF04286.7 ESA18739.1 - 0.31 10.5 12.0 0.78 9.2 4.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF445) DNA_methylase PF00145.12 ESA18739.1 - 0.36 9.8 3.6 0.39 9.7 2.5 1.0 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase SlyX PF04102.7 ESA18739.1 - 0.67 10.3 7.3 0.73 10.2 1.0 3.1 2 1 1 3 3 3 0 SlyX Mt_ATP-synt_B PF05405.9 ESA18739.1 - 0.69 9.3 10.0 0.46 9.9 3.4 2.1 1 1 1 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Spc7 PF08317.6 ESA18739.1 - 1 7.9 14.4 0.45 9.1 1.5 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein eIF-4B PF06273.6 ESA18739.1 - 1.4 7.5 6.5 1.4 7.5 4.5 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B GAS PF13851.1 ESA18739.1 - 2.3 7.3 16.2 0.99 8.5 1.8 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2262 PF10020.4 ESA18739.1 - 2.8 8.1 8.4 5.5 7.1 0.5 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) IncA PF04156.9 ESA18739.1 - 5.1 6.6 15.0 3.2 7.3 8.6 1.8 1 1 0 1 1 1 0 IncA protein TBPIP PF07106.8 ESA18739.1 - 9.5 5.7 13.6 2.3 7.7 1.7 2.2 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) bPH_4 PF06713.6 ESA18742.1 - 0.048 13.5 1.1 0.84 9.5 0.1 2.2 2 0 0 2 2 2 0 Bacterial PH domain PHD PF00628.24 ESA18744.1 - 3.5e-14 52.2 42.0 7.1e-09 35.2 7.0 4.3 3 1 1 4 4 4 2 PHD-finger PHD_2 PF13831.1 ESA18744.1 - 0.0019 17.4 1.2 0.0019 17.4 0.8 5.7 6 1 1 7 7 7 1 PHD-finger Ta0938 PF11494.3 ESA18744.1 - 0.5 10.4 4.7 1.5 8.9 2.9 2.0 1 1 1 2 2 2 0 Ta0938 C1_1 PF00130.17 ESA18744.1 - 2.3 8.0 36.5 0.28 10.9 5.1 4.7 3 2 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Metallophos PF00149.23 ESA18746.1 - 1.2e-15 57.5 2.7 1.7e-15 56.9 1.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA18746.1 - 1.2e-06 28.4 0.0 3.5e-06 26.9 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Tetraspannin PF00335.15 ESA18747.1 - 2.6e-33 115.1 13.9 3.5e-33 114.7 9.6 1.2 1 0 0 1 1 1 1 Tetraspanin family Ly49 PF08391.5 ESA18747.1 - 0.008 16.2 1.5 0.022 14.8 0.2 2.2 2 0 0 2 2 2 1 Ly49-like protein, N-terminal region FtsL PF04999.8 ESA18747.1 - 0.015 14.9 0.1 0.015 14.9 0.1 2.5 3 0 0 3 3 3 0 Cell division protein FtsL DUF1352 PF07086.7 ESA18747.1 - 0.042 13.4 0.9 0.077 12.6 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1352) CitMHS PF03600.11 ESA18747.1 - 0.085 11.4 4.0 0.37 9.3 1.5 1.9 2 0 0 2 2 2 0 Citrate transporter VirB3 PF05101.8 ESA18747.1 - 0.13 12.2 1.4 24 5.0 0.1 2.9 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein G0-G1_switch_2 PF15103.1 ESA18747.1 - 0.13 12.4 0.0 0.84 9.8 0.0 2.2 2 0 0 2 2 2 0 G0/G1 switch protein 2 Cytochrom_B_N PF00033.14 ESA18747.1 - 0.48 9.7 4.6 26 4.1 3.2 2.6 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB OAD_gamma PF04277.8 ESA18747.1 - 1 9.7 9.1 2.7 8.4 0.0 3.4 3 1 1 4 4 4 0 Oxaloacetate decarboxylase, gamma chain DUF2929 PF11151.3 ESA18747.1 - 1.1 9.4 6.9 0.24 11.5 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2929) DUF3098 PF11297.3 ESA18747.1 - 5.4 6.8 9.3 0.13 12.0 0.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3098) Synaptobrevin PF00957.16 ESA18748.1 - 0.027 14.0 1.1 10 5.8 0.0 2.8 2 0 0 2 2 2 0 Synaptobrevin Sel1 PF08238.7 ESA18752.1 - 6.9e-77 252.2 23.6 5.6e-11 42.6 0.3 9.1 9 0 0 9 9 9 9 Sel1 repeat MIT PF04212.13 ESA18752.1 - 0.00062 19.5 24.0 1.7 8.5 0.1 7.0 5 4 1 6 6 6 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA18752.1 - 0.0011 19.2 9.0 8.8 7.0 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat DUF1033 PF06279.6 ESA18752.1 - 0.029 14.1 3.4 14 5.5 0.0 4.4 3 2 1 4 4 4 0 Protein of unknown function (DUF1033) MMtag PF10159.4 ESA18752.1 - 0.078 13.0 0.8 7 6.7 0.0 2.7 2 0 0 2 2 2 0 Kinase phosphorylation protein TPR_20 PF14561.1 ESA18752.1 - 0.57 10.3 6.1 4.3 7.5 0.4 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1820 PF08850.6 ESA18752.1 - 1.1 9.3 3.6 16 5.6 0.0 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF1820) DUF4173 PF13777.1 ESA18753.1 - 0.097 11.9 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) Glyco_hydro_100 PF12899.2 ESA18754.1 - 0.06 11.7 0.2 0.065 11.6 0.1 1.1 1 0 0 1 1 1 0 Alkaline and neutral invertase VWA_3 PF13768.1 ESA18755.1 - 1.1e-29 103.0 0.0 1.7e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA18755.1 - 2.2e-16 60.0 0.0 3.4e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA18755.1 - 5.7e-15 55.8 0.0 1.4e-14 54.5 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 ESA18755.1 - 3.5e-06 26.9 0.0 6.9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF2828 PF11443.3 ESA18755.1 - 0.00036 18.8 0.1 0.00048 18.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DUF2201 PF09967.4 ESA18755.1 - 0.00036 20.5 0.0 0.00095 19.1 0.0 1.7 1 1 0 1 1 1 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.9 ESA18755.1 - 0.004 16.3 0.0 0.0067 15.5 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Luciferase_N PF05295.6 ESA18755.1 - 0.0074 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Luciferase/LBP N-terminal domain VWA_3 PF13768.1 ESA18756.1 - 2e-32 112.0 0.0 5e-32 110.7 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 ESA18756.1 - 1e-22 80.0 1.9 1e-22 80.0 1.3 2.4 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain VWA PF00092.23 ESA18756.1 - 8.4e-18 64.7 1.2 1.2e-17 64.1 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA18756.1 - 2e-15 57.3 0.0 3.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.1 ESA18756.1 - 4.4e-10 38.8 0.0 1e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2828 PF11443.3 ESA18756.1 - 1.7e-05 23.2 0.1 3.3e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) vWA-TerF-like PF10138.4 ESA18756.1 - 4.7e-05 23.3 0.0 0.00013 21.9 0.0 1.7 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.9 ESA18756.1 - 0.00025 20.2 0.1 0.00043 19.5 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF2201 PF09967.4 ESA18756.1 - 0.0009 19.2 0.0 0.0028 17.6 0.0 1.9 1 0 0 1 1 1 1 VWA-like domain (DUF2201) Luciferase_N PF05295.6 ESA18756.1 - 0.012 15.3 0.1 0.059 13.1 0.1 2.2 1 1 0 1 1 1 0 Luciferase/LBP N-terminal domain Hepatitis_core PF00906.15 ESA18756.1 - 0.088 12.4 0.1 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Hepatitis core antigen Pkinase_Tyr PF07714.12 ESA18757.1 - 1.4e-37 129.2 0.8 2.6e-37 128.2 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18757.1 - 3.1e-33 115.0 0.2 8.8e-33 113.5 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA18757.1 - 2.4e-11 43.8 4.0 1.9e-05 25.1 0.0 3.6 3 0 0 3 3 3 2 Sel1 repeat Pkinase_Tyr PF07714.12 ESA18758.1 - 8.8e-06 24.9 0.0 1.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18758.1 - 0.024 13.7 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain AAA_12 PF13087.1 ESA18759.1 - 4.6e-12 45.7 0.7 4.6e-12 45.7 0.5 1.7 2 0 0 2 2 2 1 AAA domain F-box-like PF12937.2 ESA18760.1 - 3.4e-05 23.4 1.7 4.1e-05 23.2 1.2 1.2 1 0 0 1 1 1 1 F-box-like Cytochrom_C_asm PF01578.15 ESA18761.1 - 0.00053 19.6 0.3 0.00091 18.8 0.2 1.4 1 0 0 1 1 1 1 Cytochrome C assembly protein DUF3816 PF12822.2 ESA18761.1 - 0.29 11.0 3.7 0.91 9.3 2.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) Pkinase_Tyr PF07714.12 ESA18764.1 - 1.8e-28 99.3 0.0 3.8e-28 98.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18764.1 - 5.3e-26 91.3 0.2 8.8e-26 90.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18764.1 - 0.13 11.9 0.1 0.26 10.9 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family AAA_22 PF13401.1 ESA18765.1 - 3.3e-05 24.0 0.2 0.035 14.2 0.0 4.3 3 0 0 3 3 3 1 AAA domain AAA PF00004.24 ESA18765.1 - 0.00015 21.9 0.1 0.017 15.2 0.0 4.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA18765.1 - 0.00033 20.3 0.0 0.0028 17.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Miro PF08477.8 ESA18765.1 - 0.00075 19.9 0.0 0.0039 17.6 0.0 2.3 1 0 0 1 1 1 1 Miro-like protein NACHT PF05729.7 ESA18765.1 - 0.00095 18.8 0.0 0.03 13.9 0.0 3.3 3 0 0 3 3 3 1 NACHT domain ABC_tran PF00005.22 ESA18765.1 - 0.0073 16.6 0.0 0.2 11.9 0.0 3.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.1 ESA18765.1 - 0.099 12.6 0.0 2.9 7.8 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 ESA18765.1 - 0.32 11.8 5.9 1 10.1 0.0 4.8 3 1 0 4 4 4 0 AAA domain AAA_19 PF13245.1 ESA18765.1 - 0.99 9.1 0.0 3 7.6 0.0 1.7 2 0 0 2 2 2 0 Part of AAA domain AAA_25 PF13481.1 ESA18765.1 - 2.8 7.3 0.0 6 6.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PPI_Ypi1 PF07491.6 ESA18766.1 - 0.41 10.3 6.1 0.4 10.3 1.3 2.3 1 1 1 2 2 2 0 Protein phosphatase inhibitor DUF3508 PF12018.3 ESA18766.1 - 0.61 9.0 3.8 1.5 7.7 2.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3508) p450 PF00067.17 ESA18767.1 - 1.2e-82 277.9 0.2 1.3e-82 277.7 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 PDEase_I PF00233.14 ESA18768.1 - 9.2e-53 179.4 2.0 2.5e-51 174.6 1.4 2.4 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.17 ESA18768.1 - 0.00045 20.2 0.1 0.0014 18.6 0.0 1.8 1 0 0 1 1 1 1 HD domain Pneumo_att_G PF05539.6 ESA18769.1 - 0.18 11.1 4.2 0.23 10.7 2.9 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Sec5 PF15469.1 ESA18770.1 - 2.6e-18 66.3 6.6 2.6e-18 66.3 4.6 2.8 2 0 0 2 2 2 1 Exocyst complex component Sec5 DUF2450 PF10475.4 ESA18770.1 - 1.4e-05 24.1 3.5 1.4e-05 24.1 2.4 2.0 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) Dor1 PF04124.7 ESA18770.1 - 0.0022 16.5 3.2 0.0022 16.5 2.2 1.8 2 0 0 2 2 2 1 Dor1-like family Lip_prot_lig_C PF10437.4 ESA18771.1 - 0.02 14.5 0.3 0.078 12.6 0.2 2.0 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus WXG100 PF06013.7 ESA18772.1 - 0.0055 16.6 2.3 0.15 12.0 0.1 2.4 2 0 0 2 2 2 1 Proteins of 100 residues with WXG IncA PF04156.9 ESA18772.1 - 0.0081 15.7 4.0 0.012 15.1 2.8 1.4 1 0 0 1 1 1 1 IncA protein HAUS6_N PF14661.1 ESA18772.1 - 0.064 12.6 11.0 0.027 13.8 3.0 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF869 PF05911.6 ESA18772.1 - 0.11 10.7 13.5 0.21 9.7 9.2 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) Atg14 PF10186.4 ESA18772.1 - 1.1 8.1 12.8 1.5 7.6 8.9 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3450 PF11932.3 ESA18772.1 - 1.3 8.2 9.7 1.8 7.7 6.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.3 ESA18772.1 - 2.7 7.8 19.1 1.2 8.9 10.1 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 ESA18772.1 - 6.5 5.6 22.0 11 4.9 15.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-C2H2_6 PF13912.1 ESA18774.1 - 0.0011 18.8 0.6 0.0025 17.6 0.4 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESA18774.1 - 0.0031 17.7 3.3 0.013 15.8 2.3 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger Lebercilin PF15619.1 ESA18775.1 - 0.076 12.4 10.6 0.14 11.5 7.3 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Poty_PP PF08440.5 ESA18776.1 - 0.042 12.9 2.8 0.04 12.9 2.0 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein Baculo_p24 PF05073.7 ESA18776.1 - 0.091 12.3 4.3 0.11 12.1 3.0 1.3 1 1 0 1 1 1 0 Baculovirus P24 capsid protein DUF904 PF06005.7 ESA18776.1 - 1.6 9.0 7.6 0.83 9.9 3.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Syntaxin PF00804.20 ESA18776.1 - 3.6 7.8 7.0 1 9.5 1.8 2.0 2 0 0 2 2 2 0 Syntaxin Pkinase_Tyr PF07714.12 ESA18778.1 - 0.00091 18.3 0.0 0.0019 17.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase FadA PF09403.5 ESA18778.1 - 0.0021 18.0 4.0 0.0028 17.6 2.7 1.2 1 0 0 1 1 1 1 Adhesion protein FadA Pkinase_Tyr PF07714.12 ESA18779.1 - 4.9e-05 22.5 0.1 6.3e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18779.1 - 0.0019 17.3 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Telomerase_RBD PF12009.3 ESA18782.1 - 0.067 13.0 0.7 0.067 13.0 0.5 1.9 1 1 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain DUF262 PF03235.9 ESA18783.1 - 4.2e-15 56.3 5.2 2.3e-14 53.8 3.6 2.4 1 1 0 1 1 1 1 Protein of unknown function DUF262 Rsm22 PF09243.5 ESA18783.1 - 0.1 11.6 0.1 0.27 10.2 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial small ribosomal subunit Rsm22 Sel1 PF08238.7 ESA18784.1 - 1.8e-28 98.2 12.4 1.2e-12 47.9 0.7 4.1 4 0 0 4 4 4 3 Sel1 repeat TPR_16 PF13432.1 ESA18784.1 - 0.00026 21.5 0.4 0.57 10.9 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.13 ESA18784.1 - 0.0046 16.8 8.5 0.64 9.9 0.1 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA18784.1 - 0.0046 16.5 5.3 0.36 10.5 0.1 2.8 3 1 0 3 3 3 2 TPR repeat TPR_7 PF13176.1 ESA18784.1 - 0.016 14.9 0.5 3.6 7.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Gp-FAR-1 PF05823.7 ESA18784.1 - 0.067 13.1 1.0 0.67 9.9 0.1 2.1 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) VIT PF08487.5 ESA18784.1 - 0.095 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain TPR_2 PF07719.12 ESA18784.1 - 0.099 12.6 13.6 0.46 10.5 0.1 4.1 4 1 1 5 5 4 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA18784.1 - 0.5 10.1 2.1 3.2 7.5 0.1 2.8 2 2 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation TPR_12 PF13424.1 ESA18784.1 - 0.51 10.3 6.0 14 5.7 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18784.1 - 0.8 10.3 6.6 40 4.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PV_NSP1 PF12433.3 ESA18784.1 - 2.8 8.0 6.9 15 5.7 0.3 3.1 2 2 0 2 2 2 0 Parvovirus non-structural protein 1 TPR_1 PF00515.23 ESA18784.1 - 8.9 6.1 19.4 0.72 9.5 0.2 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF3873 PF12989.2 ESA18786.1 - 0.12 12.4 0.5 0.31 11.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) DUF2708 PF10917.3 ESA18787.1 - 6.4 6.6 7.5 6.4 6.6 0.4 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2708) Pkinase PF00069.20 ESA18788.1 - 5e-23 81.5 2.1 6.3e-23 81.2 1.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18788.1 - 1.1e-14 54.1 0.7 1.4e-14 53.8 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18788.1 - 0.0011 18.7 0.0 0.12 12.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF1679 PF07914.6 ESA18788.1 - 0.0044 15.7 2.3 0.0055 15.3 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1679) Kinase-like PF14531.1 ESA18788.1 - 0.0059 15.6 0.0 0.011 14.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like EcKinase PF02958.15 ESA18788.1 - 0.0066 15.6 1.1 0.0099 15.0 0.1 1.8 2 0 0 2 2 2 1 Ecdysteroid kinase RIO1 PF01163.17 ESA18788.1 - 0.1 11.9 2.7 1.6 8.0 1.9 2.2 1 1 0 1 1 1 0 RIO1 family DUF4092 PF13322.1 ESA18790.1 - 0.082 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4092) Ion_trans PF00520.26 ESA18790.1 - 1.4 8.0 8.8 0.21 10.8 3.0 1.8 2 0 0 2 2 2 0 Ion transport protein Pkinase PF00069.20 ESA18792.1 - 0.0088 15.2 0.0 0.0099 15.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain A2L_zn_ribbon PF08792.5 ESA18793.1 - 0.13 11.7 3.2 0.37 10.3 0.1 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Cys_rich_KTR PF14205.1 ESA18793.1 - 0.28 10.6 2.2 0.44 10.0 1.5 1.4 1 1 0 1 1 1 0 Cysteine-rich KTR HTH_Tnp_Tc3_2 PF01498.13 ESA18796.1 - 1.6e-18 66.4 0.6 2e-18 66.2 0.4 1.0 1 0 0 1 1 1 1 Transposase Cullin_Nedd8 PF10557.4 ESA18796.1 - 0.028 14.2 0.3 0.045 13.5 0.2 1.5 1 1 0 1 1 1 0 Cullin protein neddylation domain HTH_DeoR PF08220.7 ESA18796.1 - 0.048 13.1 0.1 0.39 10.2 0.1 2.1 1 1 0 1 1 1 0 DeoR-like helix-turn-helix domain ICE2 PF08426.5 ESA18798.1 - 8.1e-25 87.2 15.6 1.6e-24 86.3 10.8 1.4 1 1 0 1 1 1 1 ICE2 DUF1794 PF08768.6 ESA18799.1 - 9.3e-34 116.4 0.1 1.4e-33 115.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) zf-BED PF02892.10 ESA18799.1 - 3.1e-11 42.8 0.9 3.1e-11 42.8 0.6 1.7 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_4 PF13894.1 ESA18799.1 - 0.0045 17.2 1.5 0.015 15.6 0.4 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger UPF1_Zn_bind PF09416.5 ESA18799.1 - 0.0078 15.8 0.3 0.02 14.4 0.2 1.7 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) zf-C2H2_6 PF13912.1 ESA18799.1 - 0.009 15.8 0.6 0.023 14.5 0.4 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger Usg PF06233.7 ESA18799.1 - 0.019 14.8 0.1 0.041 13.7 0.1 1.5 1 0 0 1 1 1 0 Usg-like family zf-H2C2_2 PF13465.1 ESA18799.1 - 0.062 13.6 1.6 0.97 9.8 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain DUF4451 PF14616.1 ESA18799.1 - 0.076 12.7 0.6 0.16 11.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4451) zf-C2H2 PF00096.21 ESA18799.1 - 0.51 10.7 4.3 6.1 7.3 3.0 2.6 1 1 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.2 ESA18799.1 - 0.94 9.7 3.3 1 9.6 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DDE_3 PF13358.1 ESA18800.1 - 2.6e-06 27.2 0.6 0.00038 20.2 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease ICE2 PF08426.5 ESA18800.1 - 0.045 12.3 0.0 0.051 12.1 0.0 1.0 1 0 0 1 1 1 0 ICE2 HN PF00423.14 ESA18800.1 - 0.14 10.4 0.1 0.14 10.4 0.1 1.0 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase DUF2365 PF10157.4 ESA18805.1 - 0.024 14.5 1.2 0.034 14.0 0.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) TMP_2 PF06791.8 ESA18805.1 - 0.027 14.0 0.7 0.12 12.0 0.1 1.9 1 1 1 2 2 2 0 Prophage tail length tape measure protein EAP30 PF04157.11 ESA18805.1 - 0.056 12.6 2.4 0.071 12.2 1.7 1.3 1 0 0 1 1 1 0 EAP30/Vps36 family TipAS PF07739.8 ESA18805.1 - 0.068 13.4 1.1 0.11 12.7 0.3 1.8 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain MutS_I PF01624.15 ESA18805.1 - 0.17 11.8 1.7 0.34 10.9 0.2 2.0 2 1 0 2 2 2 0 MutS domain I DUF2935 PF11155.3 ESA18805.1 - 0.24 11.4 9.4 2 8.4 1.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) SlyX PF04102.7 ESA18805.1 - 0.25 11.7 1.4 1 9.7 0.7 2.1 1 1 1 2 2 2 0 SlyX 5_3_exonuc PF01367.15 ESA18805.1 - 0.26 11.5 1.9 0.55 10.4 1.3 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Phasin PF05597.6 ESA18805.1 - 0.31 10.7 2.6 0.53 10.0 1.8 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PA26 PF04636.8 ESA18805.1 - 0.33 9.5 5.7 0.41 9.2 3.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Synaptonemal_3 PF15191.1 ESA18805.1 - 0.43 10.3 5.2 2.5 7.8 0.8 2.6 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 DUF445 PF04286.7 ESA18805.1 - 3.8 6.9 8.9 5.3 6.4 6.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) CHD5 PF04420.9 ESA18805.1 - 7.8 6.1 8.2 24 4.5 0.1 2.3 1 1 1 2 2 2 0 CHD5-like protein RVP_2 PF08284.6 ESA18807.1 - 2.2e-09 37.3 0.1 3.5e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease_2 PF13650.1 ESA18807.1 - 1.2e-07 32.1 0.0 2.4e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 ESA18807.1 - 2e-06 27.3 0.0 3.2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA18807.1 - 7.2e-06 25.7 0.0 1.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Spuma_A9PTase PF03539.9 ESA18807.1 - 0.0021 17.9 0.3 0.0057 16.5 0.0 1.9 2 1 0 2 2 2 1 Spumavirus aspartic protease (A9) Peptidase_A2B PF12384.3 ESA18807.1 - 0.0037 16.5 0.0 0.0063 15.8 0.0 1.3 1 0 0 1 1 1 1 Ty3 transposon peptidase NTP_transf_4 PF13562.1 ESA18807.1 - 0.0043 16.7 0.6 0.0083 15.7 0.4 1.4 1 0 0 1 1 1 1 Sugar nucleotidyl transferase RVP PF00077.15 ESA18807.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease V-ATPase_C PF03223.10 ESA18807.1 - 0.086 11.7 7.0 0.084 11.7 4.1 1.5 1 1 0 1 1 1 0 V-ATPase subunit C Pkinase PF00069.20 ESA18809.1 - 4.7e-36 124.2 0.0 1e-35 123.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18809.1 - 2.8e-33 115.0 0.0 3.8e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA18809.1 - 0.0032 17.2 0.0 0.0048 16.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA18809.1 - 0.041 13.4 0.4 0.41 10.1 0.0 2.4 2 1 0 3 3 3 0 Choline/ethanolamine kinase EST1 PF10374.4 ESA18810.1 - 0.043 13.8 2.2 0.095 12.7 1.5 1.6 1 0 0 1 1 1 0 Telomerase activating protein Est1 Exonuc_VII_L PF02601.10 ESA18810.1 - 3.3 6.8 9.9 10 5.2 6.7 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit RVT_1 PF00078.22 ESA18811.1 - 0.0074 15.6 0.0 0.017 14.4 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Tn7_Tnp_TnsA_N PF08722.6 ESA18811.1 - 0.097 12.6 0.6 0.15 12.1 0.3 1.5 1 1 1 2 2 2 0 TnsA endonuclease N terminal Herpes_UL6 PF01763.11 ESA18812.1 - 0.014 13.6 2.1 0.017 13.3 1.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like BTB PF00651.26 ESA18815.1 - 7.8e-18 64.4 0.1 2e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA18815.1 - 9.6e-09 35.3 4.4 1.3e-08 34.9 2.4 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA18815.1 - 6.5e-06 25.9 0.5 6.5e-06 25.9 0.3 3.1 3 1 0 4 4 4 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA18817.1 - 5.5e-08 32.1 0.1 5.6e-08 32.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18817.1 - 1.1e-06 27.9 0.0 1.5e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA18818.1 - 2.2e-22 79.4 1.7 2.6e-22 79.2 1.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18818.1 - 1.6e-15 56.8 0.3 2.2e-15 56.4 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA18818.1 - 0.00031 19.8 0.1 0.00042 19.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA18818.1 - 0.00036 19.5 0.0 0.00041 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA18818.1 - 0.076 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 ESA18818.1 - 0.17 11.5 0.0 1.8 8.2 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Nucleoplasmin PF03066.10 ESA18819.1 - 0.0089 15.5 4.3 0.017 14.6 3.0 1.5 1 0 0 1 1 1 1 Nucleoplasmin DUF2457 PF10446.4 ESA18819.1 - 0.042 12.5 9.1 0.063 12.0 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sporozoite_P67 PF05642.6 ESA18819.1 - 0.25 9.1 3.9 0.39 8.5 2.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Sec-ASP3 PF15432.1 ESA18819.1 - 0.65 9.9 4.2 1.3 8.9 0.1 2.3 1 1 0 2 2 2 0 Accessory Sec secretory system ASP3 zf-3CxxC PF13695.1 ESA18820.1 - 1.3e-05 25.3 5.1 3.3e-05 24.0 1.3 2.2 2 0 0 2 2 2 1 Zinc-binding domain DUF772 PF05598.6 ESA18820.1 - 0.11 12.3 0.6 0.29 11.0 0.1 2.0 2 0 0 2 2 2 0 Transposase domain (DUF772) TLD PF07534.11 ESA18822.1 - 1.8e-12 47.4 5.7 3e-12 46.6 3.9 1.3 1 0 0 1 1 1 1 TLD DnaI_N PF07319.6 ESA18822.1 - 0.082 13.1 9.7 1.3 9.3 1.9 3.4 3 1 1 4 4 4 0 Primosomal protein DnaI N-terminus BTB PF00651.26 ESA18823.1 - 2.8e-05 24.0 0.0 3.4e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DEAD PF00270.24 ESA18825.1 - 3e-46 156.9 0.0 1.2e-45 155.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA18825.1 - 4.8e-24 84.0 0.2 1.4e-23 82.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA18825.1 - 0.00079 19.3 0.0 0.0022 17.8 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 ESA18825.1 - 0.0056 15.1 0.7 0.16 10.3 0.0 3.2 3 1 1 4 4 4 1 Protein of unknown function (DUF1253) DUF3051 PF11252.3 ESA18825.1 - 0.096 12.1 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) ECH PF00378.15 ESA18826.1 - 1.3e-45 155.4 0.2 2.3e-45 154.6 0.2 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 ESA18826.1 - 0.0036 17.4 0.1 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region LRR_6 PF13516.1 ESA18827.1 - 1.4e-14 52.4 15.5 3.6 7.9 0.2 11.1 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.2 ESA18827.1 - 2.2e-13 49.4 7.8 0.0069 15.9 0.2 7.2 4 2 3 8 8 8 5 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA18827.1 - 3.3e-11 42.7 1.0 3.3e-11 42.7 0.7 2.5 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.1 ESA18827.1 - 4.2e-10 39.2 17.3 0.00055 19.6 0.1 5.9 4 2 1 6 6 6 4 Leucine rich repeat LRR_1 PF00560.28 ESA18827.1 - 6.1e-10 37.7 22.9 1.1 9.5 0.0 10.4 10 1 1 11 11 11 2 Leucine Rich Repeat F-box PF00646.28 ESA18827.1 - 0.0054 16.3 3.5 0.025 14.2 0.1 3.3 3 0 0 3 3 3 1 F-box domain LRR_7 PF13504.1 ESA18827.1 - 0.018 15.1 35.2 4.6 7.8 0.1 10.0 10 2 0 10 10 10 0 Leucine rich repeat Ste50p-SAM PF09235.5 ESA18827.1 - 3.1 7.9 14.1 73 3.4 0.1 6.3 4 2 3 7 7 7 0 Ste50p, sterile alpha motif DUF463 PF04317.7 ESA18829.1 - 0.017 13.6 0.1 0.021 13.4 0.1 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 DOT1 PF08123.8 ESA18830.1 - 1.4e-48 164.9 0.0 2.4e-48 164.1 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 ESA18830.1 - 3.3e-06 27.1 0.0 6.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18830.1 - 4.4e-05 23.7 0.0 9.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18830.1 - 0.00035 21.1 0.1 0.0011 19.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18830.1 - 0.0055 16.4 0.0 0.0095 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA18830.1 - 0.014 15.8 1.6 0.12 12.9 0.0 2.7 2 1 1 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.7 ESA18830.1 - 0.059 13.8 0.1 0.18 12.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain AdoMet_MTase PF07757.8 ESA18830.1 - 0.092 12.8 1.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase Mgr1 PF08602.5 ESA18830.1 - 3.2 6.6 8.3 4.8 6.0 3.9 2.1 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit CobU PF02283.11 ESA18831.1 - 0.09 12.1 2.5 0.11 11.8 1.6 1.4 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Proteasome PF00227.21 ESA18832.1 - 2.6e-55 186.6 0.0 3.5e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA18832.1 - 2e-15 55.7 0.1 3.2e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Cys_rich_VLP PF14194.1 ESA18834.1 - 0.043 13.5 0.1 0.074 12.7 0.1 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP SWIM PF04434.12 ESA18834.1 - 0.062 12.7 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 SWIM zinc finger DUF972 PF06156.8 ESA18834.1 - 0.097 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) eIF3g PF12353.3 ESA18835.1 - 0.019 14.8 1.2 0.019 14.8 0.8 1.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 ESA18835.1 - 0.02 14.8 3.2 0.033 14.1 2.2 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.1 ESA18835.1 - 0.02 14.3 0.1 0.031 13.7 0.1 1.2 1 0 0 1 1 1 0 Zinc knuckle EntA_Immun PF08951.5 ESA18836.1 - 0.042 14.0 2.2 27 5.0 0.1 3.5 3 0 0 3 3 3 0 Enterocin A Immunity Bromodomain PF00439.20 ESA18839.1 - 4.4e-17 61.7 0.4 4.6e-17 61.6 0.3 1.0 1 0 0 1 1 1 1 Bromodomain Lge1 PF11488.3 ESA18839.1 - 0.096 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 Sulfolobus_pRN PF05584.6 ESA18839.1 - 0.1 12.6 0.3 0.13 12.2 0.2 1.3 1 1 0 1 1 1 0 Sulfolobus plasmid regulatory protein DUF668 PF05003.7 ESA18840.1 - 0.017 15.2 0.1 0.037 14.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF668) DUF1599 PF07659.6 ESA18840.1 - 0.046 13.7 0.1 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1599) HMA PF00403.21 ESA18841.1 - 2.6e-07 30.6 0.0 3.4e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain HNH_3 PF13392.1 ESA18842.1 - 8.3e-11 41.1 1.5 1.5e-10 40.2 0.6 1.8 2 0 0 2 2 2 1 HNH endonuclease NUMOD4 PF07463.6 ESA18842.1 - 2.3e-05 24.1 0.0 5.9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 NUMOD4 motif NUMOD1 PF07453.8 ESA18842.1 - 6e-05 22.7 0.0 0.00015 21.4 0.0 1.8 2 0 0 2 2 2 1 NUMOD1 domain WD40 PF00400.27 ESA18843.1 - 1.4e-24 84.9 18.6 4.2e-09 35.9 0.1 5.2 4 1 1 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 ESA18843.1 - 2.8e-06 27.1 0.2 0.0038 16.9 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 ESA18843.1 - 0.0026 17.2 0.2 3.2 7.3 0.0 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.7 ESA18843.1 - 0.009 13.8 0.6 0.93 7.2 0.0 2.3 2 1 0 2 2 2 2 IKI3 family DUF1513 PF07433.6 ESA18843.1 - 0.012 14.5 0.3 0.045 12.6 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) UQ_con PF00179.21 ESA18846.1 - 2.6e-05 23.6 0.0 2.7e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Borrelia_lipo_1 PF05714.6 ESA18847.1 - 0.088 11.9 0.4 0.11 11.5 0.3 1.0 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein DUF3395 PF11875.3 ESA18848.1 - 0.086 12.4 2.3 0.16 11.5 1.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3395) HALZ PF02183.13 ESA18849.1 - 0.0066 16.1 6.2 0.0066 16.1 4.3 3.0 2 0 0 2 2 2 1 Homeobox associated leucine zipper Speriolin_N PF15058.1 ESA18849.1 - 0.92 9.3 3.1 1.8 8.4 2.2 1.4 1 0 0 1 1 1 0 Speriolin N terminus DUF1633 PF07794.6 ESA18849.1 - 2.1 6.1 4.3 3.1 5.6 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) DUF972 PF06156.8 ESA18849.1 - 4.4 7.6 27.4 0.03 14.6 8.2 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) bZIP_1 PF00170.16 ESA18849.1 - 6.1 6.8 19.0 1.1 9.2 4.2 3.1 2 0 0 2 2 2 0 bZIP transcription factor Col_cuticle_N PF01484.12 ESA18850.1 - 0.015 15.0 1.0 6.8 6.4 0.1 3.0 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain BCS1_N PF08740.6 ESA18854.1 - 1.5e-08 34.4 0.3 2.3 7.7 0.0 6.0 6 0 0 6 6 6 4 BCS1 N terminal Prp18 PF02840.10 ESA18854.1 - 3.1e-05 23.8 1.8 4.5 7.0 0.1 5.2 6 0 0 6 6 6 2 Prp18 domain DUF3830 PF12903.2 ESA18854.1 - 8.9e-05 21.9 0.0 5.7 6.3 0.0 5.5 6 0 0 6 6 6 1 Protein of unknown function (DUF3830) Flavi_capsid PF01003.14 ESA18854.1 - 0.11 12.0 0.1 8.1 6.0 0.0 2.4 2 0 0 2 2 2 0 Flavivirus capsid protein C PFU PF09070.6 ESA18855.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) PFU PF09070.6 ESA18856.1 - 0.022 14.7 0.1 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) DUF1743 PF08489.6 ESA18856.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) Pkinase_Tyr PF07714.12 ESA18857.1 - 7.2e-37 126.8 0.1 2.4e-36 125.1 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18857.1 - 4e-34 117.9 0.1 1e-33 116.6 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18857.1 - 0.038 13.7 0.1 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TLD PF07534.11 ESA18858.1 - 3.2e-14 53.1 0.2 3.2e-14 53.1 0.1 2.0 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA18858.1 - 4.6e-14 52.3 0.3 3.5e-13 49.5 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA18858.1 - 4.9e-07 29.5 1.2 1.8e-06 27.7 0.1 2.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch FAA_hydrolase PF01557.13 ESA18859.1 - 0.099 12.0 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 Fumarylacetoacetate (FAA) hydrolase family zf-C2H2 PF00096.21 ESA18860.1 - 0.016 15.5 2.3 0.016 15.5 1.6 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 ESA18860.1 - 0.017 15.0 2.3 0.027 14.3 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.1 ESA18860.1 - 0.018 15.3 1.8 0.018 15.3 1.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Polysacc_synt_4 PF04669.8 ESA18860.1 - 0.14 11.4 1.7 0.15 11.4 0.2 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis zf-met PF12874.2 ESA18860.1 - 1.6 9.0 6.5 1.1 9.5 1.0 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Bromodomain PF00439.20 ESA18861.1 - 2.7e-17 62.4 0.3 3.2e-17 62.2 0.2 1.1 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.20 ESA18862.1 - 8.1e-16 57.7 0.4 9.4e-16 57.5 0.3 1.1 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.20 ESA18863.1 - 1.3e-16 60.2 0.4 1.4e-16 60.1 0.3 1.0 1 0 0 1 1 1 1 Bromodomain Amdo_NSP PF12475.3 ESA18863.1 - 0.12 12.2 0.1 0.3 11.0 0.1 1.6 1 1 1 2 2 2 0 Amdovirus non-structural protein Pkinase_Tyr PF07714.12 ESA18864.1 - 6.5e-35 120.4 0.0 1.1e-34 119.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18864.1 - 1.5e-32 112.7 0.1 3.2e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA18864.1 - 3.2e-05 23.0 0.3 7.1e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA18864.1 - 0.064 12.2 0.1 0.13 11.2 0.1 1.5 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA18864.1 - 0.092 12.4 0.1 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BACK PF07707.10 ESA18865.1 - 0.011 15.6 1.4 1.7 8.5 0.0 2.5 2 1 0 2 2 2 0 BTB And C-terminal Kelch BTB PF00651.26 ESA18866.1 - 1.8e-17 63.3 0.3 3.2e-17 62.5 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA18866.1 - 9.6e-11 41.8 2.0 9.6e-11 41.8 1.4 2.5 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA18866.1 - 2.1e-06 27.4 0.6 8.4e-06 25.5 0.2 2.2 2 1 0 2 2 2 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA18868.1 - 1.4e-18 66.8 0.0 4.4e-18 65.2 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA18868.1 - 1.3e-17 63.8 0.2 2.5e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18868.1 - 0.016 14.9 0.1 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1542 PF07564.6 ESA18868.1 - 0.1 12.6 0.5 0.37 10.8 0.3 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) BCS1_N PF08740.6 ESA18869.1 - 2e-05 24.3 0.0 0.07 12.7 0.0 2.3 2 0 0 2 2 2 2 BCS1 N terminal DUF4413 PF14372.1 ESA18869.1 - 3.9e-05 23.5 2.6 0.087 12.8 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4413) phiKZ_IP PF12699.2 ESA18869.1 - 0.00031 19.7 0.2 0.86 8.4 0.0 3.1 2 2 1 3 3 3 2 phiKZ-like phage internal head proteins DUF3279 PF11682.3 ESA18869.1 - 0.0078 15.7 0.8 0.014 14.9 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3279) BBS2_Mid PF14783.1 ESA18869.1 - 0.022 14.5 1.3 1 9.1 0.1 2.2 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF4047 PF13256.1 ESA18869.1 - 0.051 13.5 3.6 1.1 9.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) AKAP28 PF14469.1 ESA18869.1 - 0.26 10.8 2.9 5.6 6.5 0.2 2.3 2 0 0 2 2 2 0 28 kDa A-kinase anchor HMG_box PF00505.14 ESA18870.1 - 1.1e-05 25.6 0.3 1.6e-05 25.0 0.2 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA18870.1 - 0.00014 22.1 0.3 0.0002 21.6 0.2 1.2 1 0 0 1 1 1 1 HMG-box domain RF-1 PF00472.15 ESA18871.1 - 1e-26 92.9 2.7 1.2e-26 92.6 0.0 2.2 2 1 0 2 2 2 1 RF-1 domain PCRF PF03462.13 ESA18871.1 - 3.2e-26 91.3 0.3 3.2e-26 91.3 0.2 1.8 2 0 0 2 2 2 1 PCRF domain DUF2691 PF10903.3 ESA18871.1 - 0.017 14.9 1.0 0.13 12.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2691) DASH_Dad4 PF08650.5 ESA18871.1 - 0.35 10.8 4.7 0.25 11.2 1.6 2.0 1 1 0 1 1 1 0 DASH complex subunit Dad4 His_Phos_1 PF00300.17 ESA18872.1 - 1.2e-29 103.4 0.1 1.4e-29 103.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DnaJ PF00226.26 ESA18873.1 - 1.6e-20 72.5 3.1 1.6e-20 72.5 2.2 2.4 3 0 0 3 3 3 1 DnaJ domain Myb_DNA-binding PF00249.26 ESA18873.1 - 0.037 14.0 0.0 0.13 12.2 0.0 2.0 1 0 0 1 1 1 0 Myb-like DNA-binding domain Apis_Csd PF11671.3 ESA18873.1 - 0.038 13.7 5.7 0.047 13.4 1.7 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein DUF3722 PF12519.3 ESA18874.1 - 4.6e-72 242.3 0.0 6.5e-72 241.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3722) Thg1 PF04446.7 ESA18875.1 - 2.6e-50 169.5 0.1 3.2e-50 169.2 0.1 1.1 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.1 ESA18875.1 - 1.4e-21 76.3 0.9 2.7e-21 75.4 0.6 1.5 1 0 0 1 1 1 1 Thg1 C terminal domain Sec62 PF03839.11 ESA18877.1 - 1.4e-43 148.9 5.8 3.1e-43 147.7 4.0 1.5 1 1 0 1 1 1 1 Translocation protein Sec62 Claudin_2 PF13903.1 ESA18877.1 - 0.0006 19.5 0.1 0.00074 19.2 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction DUF2628 PF10947.3 ESA18877.1 - 0.46 10.3 5.0 0.65 9.8 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) NfeD PF01957.13 ESA18877.1 - 9.8 6.3 8.6 16 5.6 5.9 1.3 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding ApoO PF09769.4 ESA18878.1 - 4.1e-27 94.8 0.0 4.5e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Apolipoprotein O DUF2590 PF10761.4 ESA18878.1 - 0.033 13.9 0.1 0.055 13.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2590) NAD_binding_9 PF13454.1 ESA18879.1 - 0.0041 16.8 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 ESA18879.1 - 0.0045 16.9 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESA18879.1 - 0.037 13.1 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.1 ESA18879.1 - 0.072 13.1 0.0 0.072 13.1 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF3482 PF11981.3 ESA18880.1 - 0.026 13.7 0.9 0.064 12.4 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) DsrC PF04358.8 ESA18880.1 - 4.1 7.7 8.4 1.3 9.3 1.1 3.1 1 1 2 3 3 3 0 DsrC like protein Methyltransf_23 PF13489.1 ESA18881.1 - 3.5e-14 52.8 0.0 6.7e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA18881.1 - 2.4e-12 47.1 0.0 4.6e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18881.1 - 7.7e-11 41.8 1.8 9.1e-11 41.5 0.3 2.0 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18881.1 - 1.1e-09 37.7 0.0 5.1e-09 35.5 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA18881.1 - 1.8e-07 31.5 0.1 6.2e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA18881.1 - 3e-07 30.7 0.0 7.4e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA18881.1 - 2e-06 27.3 0.0 3.6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 ESA18881.1 - 9e-06 26.2 0.0 8e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA18881.1 - 0.0002 20.4 1.7 0.00035 19.6 0.0 2.2 2 1 1 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA18881.1 - 0.00024 21.1 0.0 0.00053 19.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA18881.1 - 0.0013 18.7 0.0 0.011 15.7 0.0 2.2 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.11 ESA18881.1 - 0.006 14.9 0.0 0.038 12.3 0.0 2.0 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PrmA PF06325.8 ESA18881.1 - 0.0075 15.4 0.0 0.026 13.6 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 ESA18881.1 - 0.037 13.2 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase MTS PF05175.9 ESA18881.1 - 0.075 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain AdoMet_MTase PF07757.8 ESA18881.1 - 0.078 13.0 0.0 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase CWC25 PF12542.3 ESA18881.1 - 0.11 12.9 2.1 0.23 11.8 1.5 1.6 1 0 0 1 1 1 0 Pre-mRNA splicing factor TetR_C_8 PF14278.1 ESA18881.1 - 6.2 7.2 14.2 1 9.7 2.3 3.6 4 0 0 4 4 3 0 Transcriptional regulator C-terminal region p450 PF00067.17 ESA18882.1 - 1.9e-63 214.6 0.2 2.1e-63 214.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 AAA_19 PF13245.1 ESA18882.1 - 0.048 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain Endonuc-dimeris PF09124.5 ESA18884.1 - 0.068 12.8 0.7 0.31 10.7 0.1 2.3 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation IncA PF04156.9 ESA18886.1 - 0.0071 15.9 5.1 0.01 15.4 3.5 1.2 1 0 0 1 1 1 1 IncA protein V_ATPase_I PF01496.14 ESA18886.1 - 0.012 13.5 10.4 0.015 13.1 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF812 PF05667.6 ESA18886.1 - 0.042 12.3 12.1 0.057 11.9 8.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF2400 PF09674.5 ESA18886.1 - 0.15 11.7 2.9 0.31 10.7 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) V-SNARE PF05008.10 ESA18886.1 - 0.25 11.5 12.2 2.6 8.2 3.6 3.2 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus EAP30 PF04157.11 ESA18886.1 - 0.49 9.5 8.3 1.3 8.1 5.3 1.9 2 1 0 2 2 2 0 EAP30/Vps36 family Med9 PF07544.8 ESA18886.1 - 0.78 9.5 6.5 1.8 8.3 2.5 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF972 PF06156.8 ESA18886.1 - 1.1 9.6 12.4 1.8 8.9 8.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) FlxA PF14282.1 ESA18886.1 - 1.9 8.5 18.6 6.3 6.8 12.9 1.9 1 1 0 1 1 1 0 FlxA-like protein FliD_N PF02465.13 ESA18886.1 - 2 8.8 9.9 6.2 7.2 6.8 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus FlaC_arch PF05377.6 ESA18886.1 - 2.8 7.9 9.1 3.4 7.6 3.5 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TMPIT PF07851.8 ESA18886.1 - 5.8 5.8 12.6 3.4 6.6 7.4 1.5 1 1 1 2 2 2 0 TMPIT-like protein DUF1664 PF07889.7 ESA18886.1 - 8.7 6.1 11.8 1.1e+02 2.5 8.2 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) RVT_1 PF00078.22 ESA18887.1 - 8.9e-06 25.2 0.2 2.3e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 ESA18887.1 - 0.031 13.8 0.0 0.11 12.0 0.0 2.0 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase DUF4325 PF14213.1 ESA18888.1 - 0.11 12.1 0.3 0.18 11.4 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4325) WD40 PF00400.27 ESA18889.1 - 2.8e-63 207.6 28.0 5.9e-10 38.6 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 ESA18889.1 - 4.8e-14 51.4 16.5 0.023 12.8 0.1 5.8 1 1 4 6 6 6 5 Nucleoporin Nup120/160 F-box-like PF12937.2 ESA18889.1 - 6.3e-14 51.4 1.3 1.1e-13 50.6 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA18889.1 - 6.9e-12 44.7 0.3 2.4e-11 42.9 0.1 2.0 1 1 1 2 2 2 1 F-box domain BBS2_Mid PF14783.1 ESA18889.1 - 0.00047 19.9 0.2 1.3 8.7 0.0 4.2 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region TFIID_20kDa PF03847.8 ESA18890.1 - 6.3e-29 100.0 0.5 7.3e-29 99.8 0.4 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.18 ESA18890.1 - 1.4e-07 31.4 0.1 1.6e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESA18890.1 - 2.9e-06 27.2 0.0 3.6e-06 27.0 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.10 ESA18890.1 - 0.0026 17.5 0.0 0.003 17.3 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF912 PF06024.7 ESA18891.1 - 1 9.4 7.7 3.2 7.8 1.4 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4131 PF13567.1 ESA18891.1 - 1.8 7.9 6.9 0.65 9.3 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) ORMDL PF04061.9 ESA18892.1 - 7.1e-57 190.7 4.1 8.5e-57 190.5 2.9 1.1 1 0 0 1 1 1 1 ORMDL family Bap31 PF05529.7 ESA18893.1 - 9e-55 185.1 7.8 1.1e-54 184.8 5.4 1.1 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like GAS PF13851.1 ESA18893.1 - 0.04 13.0 17.0 0.045 12.9 11.1 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding HALZ PF02183.13 ESA18893.1 - 0.31 10.7 9.6 0.22 11.2 2.8 2.6 1 1 1 2 2 2 0 Homeobox associated leucine zipper AAA_23 PF13476.1 ESA18893.1 - 0.36 11.1 9.6 0.47 10.7 6.7 1.2 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.3 ESA18893.1 - 3.9 6.6 11.4 1.7 7.8 5.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1510 PF07423.6 ESA18893.1 - 9.7 5.4 14.7 1.4e+02 1.6 10.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1510) RRM_1 PF00076.17 ESA18894.1 - 1.1e-13 50.5 0.1 2.1e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18894.1 - 8.2e-10 38.3 0.0 2e-09 37.1 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18894.1 - 8.7e-09 35.2 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA18894.1 - 0.016 15.0 1.4 0.024 14.4 0.0 1.9 2 0 0 2 2 2 0 RNA binding motif MIP-T3 PF10243.4 ESA18894.1 - 0.56 8.6 7.8 0.57 8.5 5.4 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Sedlin_N PF04628.8 ESA18895.1 - 2.9e-49 166.2 0.4 3.2e-49 166.1 0.3 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 ESA18895.1 - 1.6e-07 31.1 0.2 2.1e-07 30.7 0.1 1.3 1 1 0 1 1 1 1 Sybindin-like family ATP_bind_4 PF01902.12 ESA18896.1 - 1.9e-29 102.6 0.0 2.4e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 ATP-binding region ATP_bind_3 PF01171.15 ESA18896.1 - 0.026 14.0 0.1 4.7 6.6 0.0 2.4 2 0 0 2 2 2 0 PP-loop family Asn_synthase PF00733.16 ESA18896.1 - 0.029 13.8 0.0 0.042 13.3 0.0 1.1 1 0 0 1 1 1 0 Asparagine synthase DUF3654 PF12376.3 ESA18896.1 - 0.069 12.9 0.3 0.13 12.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3654) Sel1 PF08238.7 ESA18897.1 - 4.2e-139 449.9 73.5 1.5e-11 44.5 1.2 13.0 13 0 0 13 13 13 13 Sel1 repeat Flu_M1_C PF08289.6 ESA18897.1 - 1.2e-09 38.0 0.0 0.99 9.4 0.0 7.3 3 3 3 7 7 7 2 Influenza Matrix protein (M1) C-terminal domain MIT PF04212.13 ESA18897.1 - 8.3e-06 25.5 49.8 1.2 9.1 0.1 10.9 11 1 0 11 11 11 6 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA18897.1 - 0.0018 18.5 32.0 0.67 10.5 0.1 10.0 11 0 0 11 11 11 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA18897.1 - 0.0036 17.0 15.2 25 4.6 0.0 8.1 9 0 0 9 9 9 0 Lung surfactant protein D coiled-coil trimerisation HTH_16 PF12645.2 ESA18897.1 - 0.0083 16.0 6.3 5.2 7.0 0.0 5.5 6 0 0 6 6 6 1 Helix-turn-helix domain TPR_20 PF14561.1 ESA18897.1 - 0.033 14.3 9.0 7.2 6.8 0.1 5.5 1 1 5 7 7 7 0 Tetratricopeptide repeat 23S_rRNA_IVP PF05635.6 ESA18897.1 - 0.17 11.7 4.6 13 5.7 0.0 3.6 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein BTB PF00651.26 ESA18898.1 - 2.2e-20 72.6 0.1 3.3e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA18898.1 - 0.00048 19.9 2.8 1.2 8.9 0.0 3.5 3 1 1 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA18898.1 - 0.044 12.9 0.4 0.05 12.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Urm1 PF09138.6 ESA18898.1 - 0.059 13.4 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) Ndr PF03096.9 ESA18898.1 - 0.11 10.9 0.0 0.17 10.3 0.0 1.3 1 0 0 1 1 1 0 Ndr family Chlam_OMP6 PF03504.8 ESA18898.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 6 Bcl-2 PF00452.14 ESA18898.1 - 0.14 12.3 0.1 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family BTB PF00651.26 ESA18899.1 - 2.4e-17 62.9 0.0 6.6e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA18899.1 - 1.3e-08 34.6 6.3 4.7e-06 26.3 0.4 4.2 3 1 1 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ESA18899.1 - 2.6e-08 33.9 2.9 4.7e-08 33.1 1.0 2.2 2 0 0 2 2 2 1 TLD Skp1_POZ PF03931.10 ESA18899.1 - 0.063 13.3 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Urm1 PF09138.6 ESA18899.1 - 0.096 12.8 0.1 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Urm1 (Ubiquitin related modifier) DnaB_bind PF10410.4 ESA18899.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase BTB PF00651.26 ESA18900.1 - 2.4e-10 40.3 0.0 3.1e-09 36.7 0.0 2.5 3 0 0 3 3 3 1 BTB/POZ domain RasGEF_N PF00618.15 ESA18900.1 - 0.057 13.5 1.2 0.13 12.3 0.2 2.1 2 0 0 2 2 2 0 RasGEF N-terminal motif Corona_7 PF02398.11 ESA18901.1 - 0.015 15.8 0.2 0.034 14.6 0.2 1.6 1 0 0 1 1 1 0 Coronavirus protein 7 YABBY PF04690.8 ESA18902.1 - 3.6e-06 27.3 1.3 3.6e-06 27.3 0.9 4.0 1 1 4 5 5 5 1 YABBY protein HMG_box_2 PF09011.5 ESA18902.1 - 0.00015 22.0 0.8 0.00015 22.0 0.6 2.3 1 1 1 2 2 2 1 HMG-box domain Methyltransf_11 PF08241.7 ESA18905.1 - 8e-10 39.0 0.0 1.6e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA18905.1 - 8.1e-07 28.8 0.0 1.2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA18905.1 - 1.1e-05 25.8 0.0 3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA18905.1 - 0.0083 15.2 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA18905.1 - 0.042 14.4 0.0 0.098 13.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MBOAT_2 PF13813.1 ESA18906.1 - 8.1e-12 45.0 0.2 1.4e-11 44.3 0.2 1.3 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Myb_DNA-bind_4 PF13837.1 ESA18907.1 - 1.6e-05 24.9 0.5 2.5e-05 24.3 0.4 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF4485 PF14846.1 ESA18907.1 - 0.028 14.1 0.6 0.058 13.1 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) DUF4532 PF15046.1 ESA18907.1 - 6.7 5.6 15.3 3.6 6.5 3.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4532) FTH PF01827.22 ESA18908.1 - 0.0063 16.1 1.4 0.0063 16.1 1.0 2.4 1 1 1 2 2 2 1 FTH domain MEF2_binding PF09047.5 ESA18908.1 - 0.19 11.3 1.7 6.8 6.4 0.1 2.4 2 0 0 2 2 2 0 MEF2 binding DDE_1 PF03184.14 ESA18909.1 - 1.5e-12 47.1 0.0 2.4e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA18909.1 - 0.004 16.9 0.1 0.0088 15.7 0.1 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease BING4CT PF08149.6 ESA18909.1 - 0.044 13.2 0.3 0.15 11.5 0.2 1.9 1 1 0 1 1 1 0 BING4CT (NUC141) domain COX6B PF02297.12 ESA18910.1 - 0.026 14.5 0.5 0.04 13.9 0.4 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb EF-hand_8 PF13833.1 ESA18910.1 - 0.076 12.6 1.2 0.25 10.9 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair F-box-like PF12937.2 ESA18911.1 - 1e-06 28.3 1.1 2e-06 27.4 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA18911.1 - 3.6e-06 26.4 0.0 1e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ish1 PF10281.4 ESA18911.1 - 0.012 15.7 0.4 0.028 14.4 0.3 1.7 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein 3-PAP PF12578.3 ESA18911.1 - 0.046 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Myotubularin-associated protein Caps_synth PF05704.7 ESA18914.1 - 0.026 13.6 0.3 0.044 12.9 0.2 1.3 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein DUF1741 PF08427.5 ESA18915.1 - 0.15 11.4 1.8 0.21 10.9 1.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1741) B3_4 PF03483.12 ESA18919.1 - 0.11 11.9 0.5 0.18 11.2 0.3 1.3 1 0 0 1 1 1 0 B3/4 domain GDE_N_bis PF14742.1 ESA18920.1 - 0.16 11.3 0.6 8.8 5.6 0.0 2.7 2 1 1 3 3 3 0 N-terminal domain of (some) glycogen debranching enzymes NICE-3 PF07406.6 ESA18921.1 - 2.3e-08 33.7 0.0 3e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 NICE-3 protein HDAC4_Gln PF12203.3 ESA18922.1 - 0.0027 17.6 2.8 0.0047 16.8 2.0 1.4 1 1 0 1 1 1 1 Glutamine rich N terminal domain of histone deacetylase 4 zf-B_box PF00643.19 ESA18924.1 - 0.36 10.7 4.7 0.69 9.8 3.3 1.4 1 0 0 1 1 1 0 B-box zinc finger Glyco_hydro_16 PF00722.16 ESA18925.1 - 0.031 13.5 0.1 0.035 13.3 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 16 DUF2711 PF10924.3 ESA18926.1 - 0.11 11.9 1.4 0.13 11.7 0.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2711) Isy1 PF06246.7 ESA18926.1 - 3.4 6.9 7.1 5.4 6.3 4.9 1.4 1 1 0 1 1 1 0 Isy1-like splicing family DUF2985 PF11204.3 ESA18927.1 - 0.00079 19.1 0.6 0.0016 18.1 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) DUF1003 PF06210.6 ESA18927.1 - 0.21 11.5 0.9 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) DUF2842 PF11003.3 ESA18927.1 - 3 7.7 6.2 7.7 6.4 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) RRM_1 PF00076.17 ESA18928.1 - 5.4e-13 48.3 0.0 7.5e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA18928.1 - 1.6e-11 44.0 0.0 2.1e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA18928.1 - 3e-07 30.1 0.0 4.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.7 ESA18928.1 - 0.0019 17.9 20.2 0.0025 17.5 14.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) Nup35_RRM_2 PF14605.1 ESA18928.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF566 PF04484.7 ESA18928.1 - 0.19 11.2 12.1 0.2 11.1 8.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF566) DUF4614 PF15391.1 ESA18928.1 - 0.23 11.1 6.6 0.3 10.8 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CytochromB561_N PF09786.4 ESA18928.1 - 3.9 5.8 10.2 4.4 5.6 7.1 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DUF3467 PF11950.3 ESA18929.1 - 0.13 12.2 0.2 0.15 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3467) ABC_membrane_2 PF06472.10 ESA18930.1 - 0.036 13.1 0.2 0.042 12.9 0.2 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Pkinase_Tyr PF07714.12 ESA18930.1 - 0.055 12.5 0.2 0.13 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein tyrosine kinase MinE PF03776.9 ESA18930.1 - 0.13 11.7 1.1 5.1 6.6 0.0 2.8 1 1 2 3 3 3 0 Septum formation topological specificity factor MinE LAGLIDADG_1 PF00961.14 ESA18930.1 - 0.34 11.4 2.6 0.42 11.1 1.6 1.3 1 1 0 1 1 1 0 LAGLIDADG endonuclease Pkinase_Tyr PF07714.12 ESA18932.1 - 0.056 12.5 0.2 0.11 11.5 0.0 1.5 2 0 0 2 2 2 0 Protein tyrosine kinase SAD_SRA PF02182.12 ESA18933.1 - 0.38 10.0 8.4 3.1 7.0 0.2 2.9 3 1 0 3 3 3 0 SAD/SRA domain SDA1 PF05285.7 ESA18933.1 - 1.6 7.8 31.6 3.1 6.9 4.1 2.2 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.7 ESA18933.1 - 2.4 5.9 31.1 0.52 8.1 11.4 2.1 2 0 0 2 2 2 0 Nop14-like family DUF2417 PF10329.4 ESA18934.1 - 0.0097 15.3 1.8 0.011 15.1 1.3 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) DUF2207 PF09972.4 ESA18934.1 - 0.17 10.4 0.8 0.17 10.4 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SET PF00856.23 ESA18935.1 - 1.7e-09 38.1 0.0 3.3e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 SET domain TPR_8 PF13181.1 ESA18935.1 - 0.00019 20.9 4.9 0.085 12.6 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18935.1 - 0.00035 20.8 0.1 0.54 10.8 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18935.1 - 0.0027 17.6 0.1 0.42 10.5 0.1 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA18935.1 - 0.057 13.3 2.0 10 6.3 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA18935.1 - 0.073 13.0 0.1 0.8 9.7 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA18935.1 - 0.13 13.0 0.0 25 5.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Chlorovi_GP_rpt PF06598.6 ESA18935.1 - 2.4 8.0 5.9 6.3 6.7 4.1 1.7 1 0 0 1 1 1 0 Chlorovirus glycoprotein repeat Arch_ATPase PF01637.13 ESA18936.1 - 1e-08 35.2 0.1 2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESA18936.1 - 4.1e-07 30.1 0.0 1.6e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA18936.1 - 2.9e-06 27.5 0.1 2.3e-05 24.6 0.0 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA18936.1 - 1.9e-05 24.7 0.0 9.5e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 ESA18936.1 - 0.00047 19.8 0.0 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 Part of AAA domain AAA_11 PF13086.1 ESA18936.1 - 0.00075 19.1 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA18936.1 - 0.0021 18.3 2.9 0.0062 16.8 0.1 2.8 2 2 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA18936.1 - 0.0023 17.0 0.0 0.0042 16.2 0.0 1.5 1 1 0 1 1 1 1 Zeta toxin AAA_5 PF07728.9 ESA18936.1 - 0.0028 17.3 0.0 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 ESA18936.1 - 0.0094 15.8 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESA18936.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_17 PF13207.1 ESA18936.1 - 0.018 15.8 0.3 0.065 14.0 0.1 2.1 1 1 0 2 2 2 0 AAA domain KaiC PF06745.8 ESA18936.1 - 0.039 13.0 0.3 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.1 ESA18936.1 - 0.056 12.8 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 ESA18936.1 - 0.069 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 NTPase cobW PF02492.14 ESA18936.1 - 0.11 11.9 0.0 0.24 10.7 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 ESA18936.1 - 0.11 12.1 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B UQ_con PF00179.21 ESA18938.1 - 2.8e-43 146.6 0.0 3.2e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESA18938.1 - 0.031 13.9 0.3 0.069 12.8 0.1 1.7 2 1 0 2 2 2 0 UEV domain RWD PF05773.17 ESA18938.1 - 0.15 12.0 0.2 0.21 11.4 0.1 1.4 1 1 0 1 1 1 0 RWD domain Mif2_N PF15624.1 ESA18940.1 - 0.52 10.9 6.7 0.6 10.7 4.6 1.2 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal DDE_3 PF13358.1 ESA18943.1 - 3.6e-08 33.2 1.0 9.6e-06 25.4 0.2 3.4 2 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.1 ESA18943.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HHH_3 PF12836.2 ESA18944.1 - 0.0019 18.0 0.1 0.0019 18.0 0.1 2.2 3 0 0 3 3 3 1 Helix-hairpin-helix motif Zip PF02535.17 ESA18945.1 - 0.0081 15.2 2.3 0.015 14.3 1.6 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter Pkinase_Tyr PF07714.12 ESA18946.1 - 0.029 13.4 0.2 0.056 12.5 0.0 1.5 2 0 0 2 2 2 0 Protein tyrosine kinase Myb_DNA-bind_4 PF13837.1 ESA18947.1 - 0.0081 16.2 1.3 0.017 15.2 0.9 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF3628 PF12300.3 ESA18947.1 - 0.0089 16.0 2.6 0.011 15.7 1.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3628) PPP5 PF08321.7 ESA18947.1 - 0.12 12.3 0.1 0.18 11.8 0.1 1.2 1 0 0 1 1 1 0 PPP5 TPR repeat region C1_2 PF03107.11 ESA18948.1 - 0.23 11.6 0.7 0.23 11.6 0.5 2.8 3 0 0 3 3 3 0 C1 domain Gamma-thionin PF00304.15 ESA18948.1 - 4.2 7.4 7.3 0.32 11.0 1.1 2.2 2 1 0 2 2 2 0 Gamma-thionin family Abhydrolase_3 PF07859.8 ESA18949.1 - 8.4e-46 156.2 0.0 1.5e-45 155.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA18949.1 - 6.7e-15 54.6 0.1 5.1e-14 51.7 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2424) Peptidase_S9 PF00326.16 ESA18949.1 - 0.00012 21.4 0.0 0.00022 20.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 ESA18949.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 ESA18949.1 - 0.11 11.1 4.2 0.16 10.6 0.0 2.4 3 0 0 3 3 3 0 Carboxylesterase family ALO PF04030.9 ESA18950.1 - 2.8e-90 302.4 7.8 3.4e-90 302.1 5.4 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 ESA18950.1 - 6.1e-28 97.0 0.2 8.7e-28 96.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Longin PF13774.1 ESA18951.1 - 0.072 12.6 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Regulated-SNARE-like domain YlqD PF11068.3 ESA18953.1 - 3.8 7.5 7.5 3.3 7.7 0.4 2.4 2 0 0 2 2 2 0 YlqD protein PTN_MK_C PF01091.13 ESA18954.1 - 0.28 11.2 2.4 0.36 10.8 0.3 2.0 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, C-terminal domain DUF2207 PF09972.4 ESA18955.1 - 0.068 11.7 0.6 0.076 11.5 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) YcbB PF08664.5 ESA18955.1 - 0.11 12.2 1.5 0.19 11.5 1.0 1.4 1 0 0 1 1 1 0 YcbB domain DUF1007 PF06226.8 ESA18957.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) HSDR_N_2 PF13588.1 ESA18958.1 - 0.024 14.4 0.4 0.066 13.0 0.3 1.8 1 1 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.20 ESA18959.1 - 2.3e-09 36.8 2.0 2.5e-09 36.6 1.4 1.3 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA18959.1 - 7.1e-06 25.9 0.2 3.2e-05 23.7 0.6 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA18959.1 - 4.7e-05 22.5 0.1 5.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 ESA18959.1 - 0.00011 21.9 3.0 0.00017 21.2 1.2 1.8 1 1 1 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.9 ESA18959.1 - 0.00061 18.9 0.2 0.00081 18.5 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA18959.1 - 0.11 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Kinase-like WD40 PF00400.27 ESA18960.1 - 0.013 15.3 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat POLO_box PF00659.13 ESA18960.1 - 0.18 11.7 5.6 7.6 6.5 0.6 3.6 3 0 0 3 3 3 0 POLO box duplicated region HATPase_c PF02518.21 ESA18961.1 - 4.2e-22 77.9 0.1 8.7e-22 76.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 ESA18961.1 - 1.6e-17 63.2 0.0 3.6e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.21 ESA18961.1 - 5.7e-10 39.5 0.0 2.4e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 GAF domain Response_reg PF00072.19 ESA18961.1 - 0.00052 19.9 0.0 0.0016 18.4 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain GAF_3 PF13492.1 ESA18961.1 - 0.0011 19.0 0.0 0.68 10.0 0.0 3.0 3 0 0 3 3 3 2 GAF domain HisKA PF00512.20 ESA18962.1 - 1.3e-14 53.9 0.0 1.9e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HisKA PF00512.20 ESA18963.1 - 3.6e-12 46.0 0.0 5.8e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain NOD PF06816.8 ESA18963.1 - 0.14 11.2 0.1 1.1 8.4 0.0 2.2 1 1 1 2 2 2 0 NOTCH protein Atrophin-1 PF03154.10 ESA18964.1 - 0.014 13.5 0.1 0.016 13.4 0.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family HATPase_c PF02518.21 ESA18965.1 - 2.5e-08 33.6 0.0 3.2e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 ESA18965.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase C2 PF00168.25 ESA18966.1 - 0.071 12.9 0.2 0.25 11.2 0.1 2.0 1 0 0 1 1 1 0 C2 domain Hist_deacetyl PF00850.14 ESA18967.1 - 0.08 12.2 0.4 0.096 11.9 0.3 1.2 1 0 0 1 1 1 0 Histone deacetylase domain DUF1980 PF09323.5 ESA18968.1 - 0.073 12.8 0.1 0.091 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF1785 PF08699.5 ESA18969.1 - 6.6e-12 44.5 0.0 1.1e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) FerA PF08165.6 ESA18971.1 - 0.059 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 FerA (NUC095) domain DUF3155 PF11352.3 ESA18972.1 - 0.066 13.4 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3155) F-box-like PF12937.2 ESA18974.1 - 1.2e-07 31.2 0.0 4.5e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box-like PF12937.2 ESA18975.1 - 1.8e-05 24.3 0.8 4.9e-05 22.9 0.5 1.8 1 0 0 1 1 1 1 F-box-like NADH_oxidored PF08040.6 ESA18975.1 - 0.016 14.8 0.1 0.14 11.8 0.0 2.5 3 0 0 3 3 3 0 MNLL subunit F-box-like PF12937.2 ESA18976.1 - 0.00031 20.3 0.0 0.0012 18.5 0.0 2.0 1 0 0 1 1 1 1 F-box-like SoxY PF13501.1 ESA18977.1 - 0.07 13.1 0.0 0.73 9.9 0.0 2.2 2 0 0 2 2 2 0 Sulfur oxidation protein SoxY DHC PF09626.5 ESA18977.1 - 0.099 13.3 0.1 3.1 8.5 0.0 2.4 2 0 0 2 2 2 0 Dihaem cytochrome c DUF1759 PF03564.10 ESA18977.1 - 0.25 11.1 3.5 0.16 11.7 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) DUF3250 PF11618.3 ESA18978.1 - 0.13 12.5 0.0 0.62 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3250) Atg14 PF10186.4 ESA18982.1 - 1.8e-46 158.5 3.6 2.1e-46 158.2 2.5 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 ESA18982.1 - 0.0011 18.0 7.3 0.064 12.2 0.0 2.1 2 0 0 2 2 2 2 Autophagy protein Apg6 PV-1 PF06637.6 ESA18982.1 - 0.083 11.4 5.2 0.12 10.8 3.6 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) RecR PF02132.10 ESA18982.1 - 0.23 10.9 1.1 0.42 10.0 0.8 1.4 1 0 0 1 1 1 0 RecR protein DUF730 PF05325.6 ESA18982.1 - 1.7 8.4 6.2 2.4 7.9 0.3 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF730) DUF3543 PF12063.3 ESA18983.1 - 2.4e-63 213.5 0.1 3.8e-63 212.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 ESA18983.1 - 5.1e-63 212.6 0.0 8.4e-63 211.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA18983.1 - 2.2e-42 144.9 0.0 9.3e-42 142.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA18983.1 - 0.019 13.9 0.1 0.12 11.3 0.1 2.1 1 1 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.6 ESA18983.1 - 0.025 13.3 2.0 0.04 12.6 0.0 2.0 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase APH PF01636.18 ESA18983.1 - 0.087 12.5 0.0 0.35 10.5 0.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family Cyclin_N PF00134.18 ESA18984.1 - 8.7e-09 35.0 0.5 4.2e-08 32.8 0.2 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESA18984.1 - 0.00099 19.0 0.6 0.03 14.2 0.0 3.0 3 0 0 3 3 3 1 Cyclin, C-terminal domain Endonuc-dimeris PF09124.5 ESA18984.1 - 0.011 15.2 1.4 0.033 13.8 1.0 1.8 1 0 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation Paramyxo_NS_C PF02725.9 ESA18985.1 - 0.14 11.8 5.7 0.15 11.6 3.9 1.1 1 0 0 1 1 1 0 Non-structural protein C DDRGK PF09756.4 ESA18985.1 - 0.35 10.2 13.1 0.35 10.2 9.1 1.0 1 0 0 1 1 1 0 DDRGK domain Methyltransf_8 PF05148.10 ESA18986.1 - 4.2e-58 196.5 0.0 4.9e-58 196.3 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 ESA18986.1 - 6.2e-09 36.2 0.2 2.5e-08 34.2 0.1 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA18986.1 - 8.3e-05 22.2 1.0 0.14 11.7 0.1 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 ESA18986.1 - 0.016 15.8 0.2 6.6 7.3 0.1 2.4 1 1 1 2 2 2 0 Methyltransferase domain MTS PF05175.9 ESA18986.1 - 0.029 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.13 ESA18986.1 - 0.036 13.1 0.0 0.088 11.9 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA18986.1 - 0.041 14.2 0.8 1.8 8.9 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 ESA18986.1 - 0.054 13.5 0.2 0.96 9.5 0.1 2.3 2 1 0 2 2 2 0 Methyltransferase domain Sel1 PF08238.7 ESA18987.1 - 3.9e-05 24.1 0.0 0.08 13.6 0.0 2.4 2 0 0 2 2 2 2 Sel1 repeat BTB PF00651.26 ESA18989.1 - 3.5e-18 65.6 1.8 4.3e-18 65.3 0.4 1.8 2 0 0 2 2 2 1 BTB/POZ domain DUF4535 PF15054.1 ESA18989.1 - 0.011 15.0 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) DUF3873 PF12989.2 ESA18989.1 - 0.033 14.3 0.8 0.077 13.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) BACK PF07707.10 ESA18989.1 - 0.25 11.2 2.0 19 5.1 0.1 2.6 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF659 PF04937.10 ESA18991.1 - 0.0014 18.0 0.3 0.0028 17.1 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Med31 PF05669.7 ESA18993.1 - 3.4e-38 129.5 6.2 4.8e-38 129.0 4.3 1.1 1 0 0 1 1 1 1 SOH1 KaiB PF07689.7 ESA18993.1 - 0.029 13.8 0.1 2.3 7.7 0.0 2.2 2 0 0 2 2 2 0 KaiB domain DUF724 PF05266.9 ESA18993.1 - 0.25 10.9 2.4 0.99 8.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TPR_11 PF13414.1 ESA18997.1 - 1.1e-32 111.5 34.5 5.9e-10 38.6 0.4 6.3 3 2 3 7 7 7 5 TPR repeat TPR_2 PF07719.12 ESA18997.1 - 6.7e-26 88.0 24.7 0.00018 21.2 0.1 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESA18997.1 - 1e-20 72.3 39.3 4.9e-05 22.7 0.0 9.5 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.1 ESA18997.1 - 1.1e-14 54.6 0.0 1.9e-05 25.2 0.1 5.2 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA18997.1 - 3.3e-11 42.9 22.3 0.0011 18.8 0.5 5.2 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA18997.1 - 1.4e-10 40.8 0.0 0.24 12.1 0.0 6.2 3 2 4 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA18997.1 - 2e-10 40.8 0.3 0.0063 16.8 0.1 5.9 3 2 3 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 ESA18997.1 - 6.7e-10 38.9 20.2 6.4e-07 29.4 2.5 5.3 1 1 5 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 ESA18997.1 - 1.1e-08 34.5 17.6 0.074 13.2 0.0 7.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA18997.1 - 3.2e-08 32.7 39.7 0.002 17.7 0.2 8.1 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 ESA18997.1 - 4.4e-06 26.4 0.5 0.084 12.7 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA18997.1 - 1.2e-05 25.4 7.1 0.45 11.0 0.0 6.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA18997.1 - 0.00025 20.5 12.0 0.55 10.1 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.1 ESA18997.1 - 0.009 15.9 3.2 5.9 6.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA18997.1 - 0.9 9.4 18.0 5.8 6.8 0.2 6.9 6 1 1 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Phosducin PF02114.11 ESA18999.1 - 0.051 12.2 0.1 0.052 12.2 0.1 1.0 1 0 0 1 1 1 0 Phosducin NmrA PF05368.8 ESA18999.1 - 0.056 12.6 0.0 0.056 12.6 0.0 1.0 1 0 0 1 1 1 0 NmrA-like family Vitelline_membr PF10542.4 ESA19002.1 - 0.12 12.0 2.0 0.25 11.0 1.4 1.5 1 0 0 1 1 1 0 Vitelline membrane cysteine-rich region RdRP PF05183.7 ESA19004.1 - 2.9e-27 95.6 0.0 4.1e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase DDE_Tnp_ISAZ013 PF07592.6 ESA19005.1 - 0.0011 17.7 0.0 0.069 11.8 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain zf-H2C2_2 PF13465.1 ESA19008.1 - 3.1e-23 80.8 44.5 5e-06 26.5 0.3 7.6 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.21 ESA19008.1 - 9.8e-21 72.7 49.8 4e-05 23.6 0.5 8.0 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA19008.1 - 2e-14 52.7 39.7 0.018 15.3 0.3 7.2 7 0 0 7 7 7 6 C2H2-type zinc finger DUF4570 PF15134.1 ESA19008.1 - 0.046 13.5 2.8 0.12 12.2 1.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Ogr_Delta PF04606.7 ESA19008.1 - 0.092 12.4 10.0 0.15 11.7 0.4 4.4 3 2 0 3 3 3 0 Ogr/Delta-like zinc finger zf-C2H2_6 PF13912.1 ESA19008.1 - 0.35 10.8 0.1 0.35 10.8 0.1 6.8 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA19008.1 - 0.57 10.3 17.7 23 5.2 0.9 6.0 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 ESA19008.1 - 1.2 9.4 26.7 0.83 9.9 0.6 5.9 5 2 1 6 6 6 0 CHORD FANCL_C PF11793.3 ESA19008.1 - 3.6 7.6 14.5 0.29 11.1 0.3 4.1 3 2 2 5 5 5 0 FANCL C-terminal domain B56 PF01603.15 ESA19009.1 - 4.4e-171 569.0 5.9 5e-171 568.8 4.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) OLF PF02191.11 ESA19009.1 - 0.052 12.7 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Olfactomedin-like domain Sec7_N PF12783.2 ESA19009.1 - 0.1 12.0 1.1 5.7 6.3 0.3 2.6 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1951 PF09188.5 ESA19010.1 - 0.0046 16.9 1.9 0.0053 16.7 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1951) DUF4506 PF14958.1 ESA19010.1 - 0.051 13.1 0.1 0.081 12.5 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4506) Reovirus_L2 PF06016.6 ESA19011.1 - 0.13 9.2 0.3 0.14 9.1 0.2 1.0 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) Col_cuticle_N PF01484.12 ESA19012.1 - 0.013 15.1 0.4 0.013 15.1 0.3 1.7 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Glyco_hydro_88 PF07470.8 ESA19012.1 - 0.081 11.9 0.0 0.09 11.7 0.0 1.0 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 DUF2625 PF10946.3 ESA19014.1 - 0.012 14.5 0.5 0.088 11.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF2625 SAM_1 PF00536.25 ESA19015.1 - 0.00012 22.1 0.2 0.0002 21.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.12 ESA19016.1 - 3.5e-40 137.7 1.4 5.4e-40 137.1 1.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19016.1 - 2.6e-36 125.1 4.6 4.6e-36 124.3 3.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA19016.1 - 3.9e-15 55.9 6.6 2.9e-06 27.7 0.1 3.5 3 0 0 3 3 3 3 Sel1 repeat Kinase-like PF14531.1 ESA19016.1 - 0.001 18.0 0.0 0.0022 16.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Chordopox_A30L PF06015.7 ESA19017.1 - 0.25 10.9 8.0 3.6 7.2 0.1 2.0 1 1 1 2 2 2 0 Chordopoxvirus A30L protein F-box-like PF12937.2 ESA19019.1 - 0.066 12.9 1.3 0.17 11.6 0.3 2.1 2 0 0 2 2 2 0 F-box-like Methyltransf_20 PF12147.3 ESA19019.1 - 0.14 10.9 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Myb_DNA-bind_6 PF13921.1 ESA19020.1 - 0.072 13.1 4.5 0.15 12.1 0.7 2.3 1 1 1 2 2 2 0 Myb-like DNA-binding domain SapB_1 PF05184.10 ESA19020.1 - 0.095 12.5 0.2 21 5.0 0.0 2.6 2 0 0 2 2 2 0 Saposin-like type B, region 1 RVT_1 PF00078.22 ESA19021.1 - 0.018 14.3 0.1 0.15 11.3 0.0 2.2 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) PMC2NT PF08066.7 ESA19021.1 - 2.2 8.6 4.9 1.1 9.6 0.1 2.7 3 1 1 4 4 4 0 PMC2NT (NUC016) domain USP7_ICP0_bdg PF12436.3 ESA19022.1 - 6.6e-117 389.1 16.7 6.4e-61 205.7 0.6 3.5 4 0 0 4 4 4 3 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA19022.1 - 2.2e-60 203.7 21.6 2.3e-57 193.8 7.6 4.3 4 0 0 4 4 4 3 Ubiquitin-specific protease C-terminal ubiquitin PF00240.18 ESA19022.1 - 0.00024 20.4 1.8 0.63 9.4 0.0 3.5 3 0 0 3 3 3 2 Ubiquitin family YukD PF08817.5 ESA19022.1 - 0.016 15.7 0.0 1 9.9 0.0 3.1 3 0 0 3 3 3 0 WXG100 protein secretion system (Wss), protein YukD TipAS PF07739.8 ESA19022.1 - 0.018 15.3 0.0 0.66 10.3 0.0 2.4 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Phage_terminase PF10668.4 ESA19022.1 - 0.053 13.3 0.4 1.1 9.0 0.1 2.5 2 0 0 2 2 2 0 Phage terminase small subunit DUF446 PF04287.7 ESA19022.1 - 0.073 12.8 3.0 12 5.7 0.1 3.2 3 0 0 3 3 3 0 tRNA pseudouridine synthase C UN_NPL4 PF11543.3 ESA19022.1 - 0.1 12.8 4.1 2.4 8.4 0.0 4.2 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 Rad60-SLD PF11976.3 ESA19022.1 - 1.5 8.5 8.8 20 4.9 0.1 5.3 5 2 0 5 5 5 0 Ubiquitin-2 like Rad60 SUMO-like TFIIS_M PF07500.9 ESA19023.1 - 0.05 13.6 4.5 0.16 12.0 3.1 1.8 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain P35 PF02331.10 ESA19023.1 - 0.091 11.8 5.6 0.095 11.8 3.9 1.1 1 0 0 1 1 1 0 Apoptosis preventing protein Sec62 PF03839.11 ESA19023.1 - 1.8 7.9 6.1 1.8 7.9 4.2 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 Apis_Csd PF11671.3 ESA19023.1 - 3.3 7.4 8.9 4.1 7.1 6.2 1.0 1 0 0 1 1 1 0 Complementary sex determiner protein Synaptobrevin PF00957.16 ESA19024.1 - 1.4e-32 111.1 5.0 1.7e-32 110.8 3.5 1.0 1 0 0 1 1 1 1 Synaptobrevin ODV-E18 PF10717.4 ESA19024.1 - 0.039 13.3 0.1 0.063 12.7 0.0 1.5 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 MMPL PF03176.10 ESA19024.1 - 0.04 12.6 0.1 0.045 12.4 0.1 1.1 1 0 0 1 1 1 0 MMPL family InaF-motif PF15018.1 ESA19024.1 - 0.045 13.2 1.7 0.077 12.4 1.2 1.4 1 0 0 1 1 1 0 TRP-interacting helix DUF948 PF06103.6 ESA19024.1 - 0.33 10.8 5.6 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF515 PF04415.7 ESA19024.1 - 1.1 7.4 4.7 0.75 7.9 2.6 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF515) UXS1_N PF11803.3 ESA19024.1 - 2.1 8.1 4.5 3.7 7.3 0.1 2.4 2 1 1 3 3 3 0 UDP-glucuronate decarboxylase N-terminal DUF3139 PF11337.3 ESA19024.1 - 3.8 7.8 6.4 7.2 6.9 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) RRM_6 PF14259.1 ESA19025.1 - 1.2e-08 34.7 0.0 2.8e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA19025.1 - 1.5e-06 27.7 0.0 9.5e-06 25.1 0.0 2.5 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA19025.1 - 0.00013 21.7 0.0 0.00044 20.0 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.1 ESA19025.1 - 0.00093 18.8 6.5 0.0025 17.4 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA19025.1 - 0.0069 16.0 7.2 0.018 14.6 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA19025.1 - 0.013 15.1 8.2 0.044 13.5 5.6 2.0 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA19025.1 - 0.47 10.5 11.5 0.3 11.1 5.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.1 ESA19025.1 - 0.66 9.5 5.5 2 7.9 3.8 1.8 1 0 0 1 1 1 0 Transposase zinc-binding domain FAD-oxidase_C PF02913.14 ESA19026.1 - 2.2e-56 190.9 0.0 2.8e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 ESA19026.1 - 1.5e-34 118.4 0.1 2.6e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Relaxase PF03432.9 ESA19026.1 - 0.1 11.9 0.1 0.31 10.3 0.0 1.7 2 0 0 2 2 2 0 Relaxase/Mobilisation nuclease domain BACK PF07707.10 ESA19026.1 - 0.16 11.8 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 BTB And C-terminal Kelch BTB PF00651.26 ESA19029.1 - 2.6e-21 75.6 0.0 4.5e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA19029.1 - 7.5e-11 41.7 7.9 6.7e-08 32.2 0.1 4.3 4 1 1 5 5 5 3 BTB And C-terminal Kelch Peptidase_M1 PF01433.15 ESA19030.1 - 1.2e-75 255.0 0.0 1.8e-75 254.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 ESA19030.1 - 2.6e-42 143.7 0.4 5.2e-42 142.8 0.3 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 ESA19030.1 - 1.1e-13 51.3 0.0 1.8e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 ESA19030.1 - 0.092 12.7 1.5 0.37 10.7 1.0 2.0 1 1 0 1 1 1 0 M61 glycyl aminopeptidase PTS_EIIB PF00367.15 ESA19032.1 - 0.0089 15.2 7.4 4.7 6.5 0.0 4.1 4 0 0 4 4 4 2 phosphotransferase system, EIIB Glyco_hydro_2 PF00703.16 ESA19032.1 - 0.058 13.8 0.4 0.31 11.5 0.3 1.9 1 1 0 1 1 1 0 Glycosyl hydrolases family 2 DREPP PF05558.7 ESA19032.1 - 0.074 12.8 1.6 4.9 6.9 0.2 2.4 1 1 3 4 4 4 0 DREPP plasma membrane polypeptide DUF2490 PF10677.4 ESA19032.1 - 0.14 11.4 3.3 0.31 10.2 2.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2490) SpoVG PF04026.7 ESA19032.1 - 0.19 11.8 5.2 42 4.2 0.0 3.9 1 1 3 4 4 4 0 SpoVG DUF2418 PF10332.4 ESA19032.1 - 1.5 9.1 6.1 4.3 7.6 1.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2418) RNA_pol_Rpb6 PF01192.17 ESA19032.1 - 7.2 6.4 10.3 26 4.6 0.2 3.6 4 0 0 4 4 4 0 RNA polymerase Rpb6 7tm_1 PF00001.16 ESA19033.1 - 0.066 12.3 0.5 0.076 12.1 0.4 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Orthoreo_P10 PF07204.6 ESA19033.1 - 7.6 6.3 7.3 2.2 8.0 1.5 2.6 1 1 1 2 2 2 0 Orthoreovirus membrane fusion protein p10 Sec34 PF04136.10 ESA19034.1 - 0.11 12.1 0.2 0.14 11.8 0.1 1.1 1 0 0 1 1 1 0 Sec34-like family BTB PF00651.26 ESA19037.1 - 3.1e-20 72.1 0.0 6.5e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19037.1 - 3.4e-10 40.0 0.6 1e-09 38.4 0.4 1.9 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA19037.1 - 7.6e-08 32.1 0.5 1.4e-05 24.8 0.1 3.0 1 1 2 3 3 3 2 BTB And C-terminal Kelch AMP-binding PF00501.23 ESA19038.1 - 3.9e-95 318.6 0.0 4.8e-95 318.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESA19038.1 - 6.7e-20 71.8 0.0 1.5e-19 70.7 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MRP-S24 PF14955.1 ESA19039.1 - 0.0086 15.9 0.1 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 RNaseH_C PF09293.5 ESA19039.1 - 0.09 12.6 3.2 0.081 12.8 1.1 1.7 1 1 1 2 2 2 0 T4 RNase H, C terminal HSP70 PF00012.15 ESA19040.1 - 4.4e-201 668.9 4.6 5.4e-201 668.6 3.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA19040.1 - 1.3e-19 70.0 1.8 5.3e-17 61.4 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DDR PF08841.5 ESA19040.1 - 0.011 14.6 0.2 0.2 10.4 0.0 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain NUT_C PF12882.2 ESA19040.1 - 0.029 13.9 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 NUT protein C terminal Actin PF00022.14 ESA19040.1 - 0.069 11.5 0.0 3.8 5.8 0.0 2.1 1 1 1 2 2 2 0 Actin HSP70 PF00012.15 ESA19041.1 - 5e-191 635.7 6.8 4.9e-190 632.4 4.7 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA19041.1 - 5.2e-13 48.2 1.4 5.7e-13 48.1 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 ESA19041.1 - 0.0012 18.5 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.5 ESA19041.1 - 0.056 12.2 0.1 0.22 10.2 0.1 1.8 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain GvpG PF05120.7 ESA19042.1 - 0.0084 15.8 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Gas vesicle protein G DMAP_binding PF06464.6 ESA19042.1 - 0.1 13.1 0.0 0.12 12.9 0.0 1.1 1 0 0 1 1 1 0 DMAP1-binding Domain 7TM_GPCR_Sra PF02117.11 ESA19045.1 - 0.018 13.6 0.2 0.026 13.1 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra PRP38_assoc PF12871.2 ESA19046.1 - 0.0004 20.8 28.0 0.0004 20.8 19.4 2.4 2 0 0 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF1777 PF08648.7 ESA19046.1 - 0.16 11.7 40.6 0.32 10.7 28.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) DUF1509 PF07420.6 ESA19046.1 - 5.6 6.1 14.3 6.5 5.9 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) MIP-T3 PF10243.4 ESA19046.1 - 6.5 5.1 27.6 8.3 4.7 19.1 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Ribosomal_L23 PF00276.15 ESA19047.1 - 0.091 12.7 0.2 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L23 Codanin-1_C PF15296.1 ESA19047.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Codanin-1 C-terminus RRM_1 PF00076.17 ESA19049.1 - 1.3e-32 111.2 0.0 5.3e-15 54.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA19049.1 - 1.9e-22 78.9 0.0 1.2e-10 41.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA19049.1 - 1.6e-10 40.6 0.0 0.00013 21.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA19049.1 - 0.006 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA binding motif zf-C2H2_jaz PF12171.3 ESA19050.1 - 0.0044 17.1 0.9 0.014 15.4 0.6 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding CARDB PF07705.6 ESA19050.1 - 0.068 13.2 0.7 0.12 12.3 0.1 1.6 1 1 1 2 2 2 0 CARDB zf-met PF12874.2 ESA19050.1 - 0.11 12.7 1.0 0.38 11.0 0.7 2.1 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 ESA19050.1 - 0.14 12.5 6.2 0.16 12.4 2.0 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met2 PF12907.2 ESA19050.1 - 0.34 10.8 2.7 1.3 9.0 1.9 2.0 1 0 0 1 1 1 0 Zinc-binding zf-C2H2 PF00096.21 ESA19050.1 - 0.8 10.1 8.3 0.15 12.4 2.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Pkinase_Tyr PF07714.12 ESA19051.1 - 1.1e-19 70.5 0.0 4.7e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19051.1 - 3.9e-18 65.5 3.8 6.2e-16 58.3 1.3 2.5 2 1 0 2 2 2 2 Protein kinase domain PTH2 PF01981.11 ESA19051.1 - 0.0041 16.8 0.0 2.2 7.9 0.0 2.3 2 0 0 2 2 2 2 Peptidyl-tRNA hydrolase PTH2 Frataxin_Cyay PF01491.11 ESA19051.1 - 0.021 14.5 0.2 1.5 8.6 0.0 2.7 2 0 0 2 2 2 0 Frataxin-like domain NNMT_PNMT_TEMT PF01234.12 ESA19051.1 - 0.022 13.7 1.1 0.08 11.8 0.1 2.0 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family BCS1_N PF08740.6 ESA19051.1 - 0.026 14.1 0.0 0.077 12.6 0.0 1.8 2 0 0 2 2 2 0 BCS1 N terminal Chordopox_A30L PF06015.7 ESA19052.1 - 0.17 11.4 4.4 0.17 11.4 2.2 1.8 2 0 0 2 2 2 0 Chordopoxvirus A30L protein Peptidase_S8 PF00082.17 ESA19053.1 - 8e-52 176.1 0.1 2.6e-51 174.4 0.1 1.9 2 0 0 2 2 2 1 Subtilase family TPPII PF12580.3 ESA19053.1 - 8e-47 159.0 0.1 1.3e-46 158.3 0.1 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II TPPII_N PF12583.3 ESA19053.1 - 0.00076 19.6 0.1 0.00076 19.6 0.0 1.9 2 0 0 2 2 2 1 Tripeptidyl peptidase II N terminal HSDR_N PF04313.9 ESA19054.1 - 0.0036 17.0 0.0 0.0049 16.6 0.0 1.4 1 1 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase PF00069.20 ESA19055.1 - 4.5e-11 42.3 0.3 6.5e-11 41.8 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19055.1 - 9.1e-10 38.0 0.1 1.6e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2740 PF10872.3 ESA19056.1 - 0.094 12.3 0.2 0.35 10.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) KH_1 PF00013.24 ESA19057.1 - 1.1e-05 25.0 0.9 0.042 13.5 0.0 2.3 2 0 0 2 2 2 2 KH domain HSF_DNA-bind PF00447.12 ESA19058.1 - 4.8e-36 123.0 1.2 4.8e-36 123.0 0.8 2.0 2 1 0 2 2 2 1 HSF-type DNA-binding RNase_E_G PF10150.4 ESA19058.1 - 0.014 14.6 0.5 0.022 14.0 0.4 1.3 1 0 0 1 1 1 0 Ribonuclease E/G family Nup54 PF13874.1 ESA19058.1 - 0.047 13.3 4.1 0.087 12.4 2.8 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 KIAA1430 PF13879.1 ESA19058.1 - 0.18 12.2 9.3 0.45 10.9 6.5 1.7 1 0 0 1 1 1 0 KIAA1430 homologue NAD_binding_6 PF08030.7 ESA19058.1 - 0.75 9.6 3.4 1.9 8.3 1.3 2.2 1 1 1 2 2 2 0 Ferric reductase NAD binding domain DUF2400 PF09674.5 ESA19058.1 - 3 7.4 7.0 0.38 10.4 1.4 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2400) EF-hand_1 PF00036.27 ESA19060.1 - 2.6e-17 60.7 7.9 8.8e-06 24.6 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESA19060.1 - 5e-16 58.5 11.9 5.1e-09 36.1 0.8 3.1 1 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 ESA19060.1 - 1.5e-15 55.6 4.5 5.2e-05 22.7 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 ESA19060.1 - 1.3e-12 46.4 7.7 1.6e-05 23.9 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 ESA19060.1 - 2.1e-11 43.2 4.1 0.001 18.6 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 ESA19060.1 - 2.6e-06 27.4 0.1 0.0064 16.5 0.0 2.4 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 ESA19060.1 - 0.0019 17.8 4.3 1 9.0 0.1 3.6 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.2 ESA19060.1 - 0.0097 15.6 1.4 0.73 9.5 0.1 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF1322 PF07032.6 ESA19060.1 - 0.025 14.7 2.5 0.039 14.1 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1322) RRM_1 PF00076.17 ESA19061.1 - 5.8e-05 22.6 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1754 PF08555.5 ESA19061.1 - 0.0003 21.3 8.4 0.00054 20.5 5.8 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) RRM_6 PF14259.1 ESA19061.1 - 0.081 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.7 ESA19061.1 - 0.2 11.3 21.5 0.33 10.6 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) BTV_NS2 PF04514.7 ESA19061.1 - 2.6 6.8 12.6 3.4 6.4 8.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 TLD PF07534.11 ESA19062.1 - 3.8e-08 33.4 0.6 3.8e-08 33.4 0.4 2.9 3 1 0 3 3 3 1 TLD BACK PF07707.10 ESA19062.1 - 3.7e-07 29.9 2.5 6.5e-06 25.9 0.2 3.1 2 1 1 3 3 3 1 BTB And C-terminal Kelch Urm1 PF09138.6 ESA19062.1 - 0.055 13.5 0.1 0.19 11.8 0.1 2.0 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) TLD PF07534.11 ESA19063.1 - 8.8e-13 48.4 0.5 1.8e-12 47.4 0.3 1.5 1 0 0 1 1 1 1 TLD Mn_catalase PF05067.7 ESA19064.1 - 0.061 12.0 0.3 0.12 11.0 0.0 1.5 2 0 0 2 2 2 0 Manganese containing catalase Aldo_ket_red PF00248.16 ESA19066.1 - 8.3e-43 146.2 0.0 9.3e-43 146.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase_Tyr PF07714.12 ESA19068.1 - 9.7e-45 152.6 0.0 1.4e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19068.1 - 2.5e-40 138.2 0.0 3.5e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA19068.1 - 0.0006 18.9 0.1 0.00094 18.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA19068.1 - 0.00067 18.7 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA19068.1 - 0.0062 16.2 0.1 0.0091 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PsbU PF06514.6 ESA19068.1 - 0.036 13.8 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Tht1 PF04163.7 ESA19069.1 - 7e-07 28.0 1.9 7e-07 28.0 1.3 1.6 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Mnd1 PF03962.10 ESA19069.1 - 0.0096 15.5 0.1 0.022 14.3 0.1 1.7 1 1 0 1 1 1 1 Mnd1 family Reo_sigmaC PF04582.7 ESA19069.1 - 0.066 12.3 1.0 0.097 11.8 0.5 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein ArfGap PF01412.13 ESA19070.1 - 1.8e-38 130.8 0.3 1.4e-37 128.0 0.1 2.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 ESA19070.1 - 8.2e-17 61.3 0.3 4e-16 59.0 0.0 2.3 2 1 0 2 2 2 1 PH domain Ank_2 PF12796.2 ESA19070.1 - 9.9e-13 48.2 6.3 5.3e-10 39.4 0.6 2.7 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESA19070.1 - 1e-10 41.4 1.7 7e-05 22.9 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 ESA19070.1 - 1e-09 38.6 3.0 0.00044 20.6 0.7 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) PH_11 PF15413.1 ESA19070.1 - 1.9e-06 28.1 0.2 3.2e-05 24.1 0.1 3.0 1 1 0 1 1 1 1 Pleckstrin homology domain Ank PF00023.25 ESA19070.1 - 2.4e-06 27.0 3.1 0.015 15.0 0.2 3.2 3 0 0 3 3 3 2 Ankyrin repeat PH_8 PF15409.1 ESA19070.1 - 3.6e-05 23.7 0.0 0.0003 20.8 0.0 2.5 3 0 0 3 3 3 1 Pleckstrin homology domain PH_3 PF14593.1 ESA19070.1 - 0.0021 17.8 0.2 0.017 15.0 0.0 2.5 2 0 0 2 2 2 1 PH domain Ank_3 PF13606.1 ESA19070.1 - 0.0026 17.8 2.7 0.29 11.4 0.2 3.3 3 0 0 3 3 3 1 Ankyrin repeat BTB PF00651.26 ESA19071.1 - 2.2e-16 59.8 0.5 6.4e-16 58.3 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA19071.1 - 1.4e-07 31.3 3.2 3e-07 30.2 0.1 3.0 4 0 0 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ESA19071.1 - 4e-06 26.8 5.2 4e-06 26.8 3.6 2.1 2 0 0 2 2 2 1 TLD GLF PF03275.8 ESA19072.1 - 0.019 14.4 0.2 0.82 9.1 0.1 2.4 2 0 0 2 2 2 0 UDP-galactopyranose mutase GxDLY PF14607.1 ESA19073.1 - 0.073 12.5 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type DUF3447 PF11929.3 ESA19073.1 - 0.82 9.5 4.1 2.5 7.9 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) GxDLY PF14607.1 ESA19076.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type DZR PF12773.2 ESA19077.1 - 0.038 13.8 1.9 0.038 13.8 1.3 1.6 2 0 0 2 2 2 0 Double zinc ribbon zf-tcix PF14952.1 ESA19077.1 - 0.053 12.8 1.2 0.053 12.8 0.8 1.6 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding Lar_restr_allev PF14354.1 ESA19077.1 - 0.056 13.7 2.2 0.65 10.3 1.5 2.2 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.1 ESA19077.1 - 0.21 10.8 3.4 0.58 9.4 2.4 1.8 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 ESA19077.1 - 1.4 8.8 4.0 2.1 8.3 0.4 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Pkinase_Tyr PF07714.12 ESA19078.1 - 2.7e-26 92.2 0.0 3.2e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19078.1 - 5.9e-23 81.3 0.0 8e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19079.1 - 1.8e-39 135.3 0.0 2.4e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19079.1 - 1.3e-30 106.4 0.0 2.1e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19080.1 - 0.043 12.8 0.0 0.054 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase DUF4101 PF13355.1 ESA19081.1 - 0.18 12.2 2.2 0.34 11.3 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4101) RNA_pol_Rpb4 PF03874.11 ESA19081.1 - 0.26 11.3 5.0 6.4 6.8 0.1 3.3 2 1 1 3 3 3 0 RNA polymerase Rpb4 F-box-like PF12937.2 ESA19083.1 - 0.00013 21.6 2.3 0.00027 20.5 1.6 1.5 1 1 0 1 1 1 1 F-box-like PAN_4 PF14295.1 ESA19084.1 - 0.28 10.9 12.2 0.25 11.0 5.5 2.5 2 0 0 2 2 2 0 PAN domain SoxE PF06525.6 ESA19084.1 - 4 6.6 21.0 7.6 5.7 7.4 2.6 2 1 0 2 2 2 0 Sulfocyanin (SoxE) BTB PF00651.26 ESA19088.1 - 3.2e-16 59.2 0.1 6.9e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19088.1 - 1.6e-07 31.3 4.6 3.7e-07 30.2 3.2 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA19088.1 - 0.0019 18.0 0.3 0.13 12.0 0.1 2.8 1 1 1 2 2 2 1 BTB And C-terminal Kelch RrnaAD PF00398.15 ESA19088.1 - 0.05 12.6 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FANCI_S2 PF14676.1 ESA19088.1 - 0.071 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 FANCI solenoid 2 BTB PF00651.26 ESA19089.1 - 5.3e-17 61.8 0.0 1.1e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19089.1 - 4e-09 36.5 4.6 7.3e-09 35.7 3.2 1.5 1 0 0 1 1 1 1 TLD UQ_con PF00179.21 ESA19091.1 - 0.0032 16.9 0.1 0.0064 15.9 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme DBD_Tnp_Mut PF03108.10 ESA19091.1 - 0.063 12.8 0.2 0.085 12.4 0.1 1.2 1 0 0 1 1 1 0 MuDR family transposase AAA_12 PF13087.1 ESA19092.1 - 2.2e-36 125.1 3.0 7.4e-36 123.4 1.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA19092.1 - 1.2e-11 44.6 1.8 2.2e-11 43.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 ESA19092.1 - 0.13 12.3 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain F-box-like PF12937.2 ESA19093.1 - 5.6e-05 22.7 0.1 0.00019 21.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like Flg_new PF09479.5 ESA19096.1 - 0.019 14.9 0.4 0.045 13.7 0.1 1.7 2 0 0 2 2 2 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Cupredoxin_1 PF13473.1 ESA19096.1 - 0.48 10.3 2.6 7.6 6.4 1.8 2.0 1 1 0 1 1 1 0 Cupredoxin-like domain Sel1 PF08238.7 ESA19097.1 - 2.2e-52 174.3 12.9 1.8e-10 41.1 1.2 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA19097.1 - 0.00014 22.0 6.2 0.4 11.2 0.3 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat MIT PF04212.13 ESA19097.1 - 0.0023 17.7 17.3 0.073 12.9 0.4 4.8 2 2 3 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_20 PF14561.1 ESA19097.1 - 0.021 14.9 4.0 1.5 9.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Exo_endo_phos_2 PF14529.1 ESA19097.1 - 0.033 13.8 0.1 0.073 12.6 0.0 1.6 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase TPR_11 PF13414.1 ESA19097.1 - 0.038 13.6 22.1 1.1 8.9 0.8 4.7 2 2 3 5 5 5 0 TPR repeat TPR_17 PF13431.1 ESA19097.1 - 0.18 12.1 15.9 3.3 8.1 0.0 5.6 4 2 1 5 5 5 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA19098.1 - 6.4e-05 22.5 1.2 0.00012 21.7 0.8 1.5 1 1 0 1 1 1 1 F-box-like AAA_12 PF13087.1 ESA19102.1 - 1.6e-36 125.5 1.7 2.9e-36 124.7 1.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA19102.1 - 1.9e-11 44.0 0.2 5.3e-11 42.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain Pox_D5 PF03288.11 ESA19104.1 - 0.073 13.3 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 Poxvirus D5 protein-like Dala_Dala_lig_C PF07478.8 ESA19106.1 - 0.11 11.8 0.2 0.15 11.3 0.1 1.1 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Arrestin_C PF02752.17 ESA19107.1 - 9.8e-19 67.8 11.4 2e-17 63.5 3.1 2.6 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 ESA19107.1 - 5.2e-14 52.3 9.3 1.8e-11 44.0 0.1 4.2 4 1 0 4 4 4 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 ESA19107.1 - 1.7e-05 24.4 0.4 0.00013 21.5 0.0 2.5 3 1 0 3 3 3 1 Arrestin_N terminal like CIAPIN1 PF05093.8 ESA19109.1 - 0.05 13.6 0.3 0.1 12.7 0.0 1.6 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Pkinase_Tyr PF07714.12 ESA19111.1 - 0.0052 15.8 0.1 0.0066 15.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LptC PF06835.8 ESA19112.1 - 0.00035 20.0 0.0 0.00042 19.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide-assembly, LptC-related AAA_12 PF13087.1 ESA19114.1 - 1.2e-36 125.9 0.8 1.2e-36 125.9 0.5 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 ESA19114.1 - 2.1e-06 27.4 0.0 2.1e-06 27.4 0.0 2.2 3 0 0 3 3 3 1 AAA domain BTB PF00651.26 ESA19115.1 - 6.5e-19 67.9 0.0 8.8e-19 67.5 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA19115.1 - 0.021 13.9 0.0 0.025 13.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Beach PF02138.13 ESA19116.1 - 5.2e-50 170.3 0.0 7.3e-50 169.9 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.27 ESA19116.1 - 1.6e-16 59.4 7.4 1.4e-06 27.9 0.5 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat FYVE PF01363.16 ESA19116.1 - 8.7e-11 41.5 11.8 3.2e-10 39.7 8.2 1.9 1 1 0 1 1 1 1 FYVE zinc finger Nucleoporin_N PF08801.6 ESA19116.1 - 0.22 10.2 2.4 4.4 5.9 0.4 2.3 1 1 1 2 2 2 0 Nup133 N terminal like PAP2 PF01569.16 ESA19117.1 - 7.7e-10 38.5 4.7 7.7e-10 38.5 3.2 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 ESA19117.1 - 8.6e-05 22.1 3.0 0.00016 21.3 2.1 1.4 1 0 0 1 1 1 1 PAP2 superfamily DUF89 PF01937.14 ESA19118.1 - 6.5e-122 406.7 3.3 7.4e-122 406.5 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Osteoregulin PF07175.6 ESA19118.1 - 0.14 11.9 0.2 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Osteoregulin Rsa3 PF14615.1 ESA19119.1 - 2.3e-09 36.4 0.7 4.3e-09 35.5 0.5 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 NVEALA PF14055.1 ESA19119.1 - 0.15 11.7 0.9 0.34 10.6 0.7 1.7 1 0 0 1 1 1 0 NVEALA protein Nop14 PF04147.7 ESA19119.1 - 1.1 7.1 36.3 1.3 6.8 25.1 1.0 1 0 0 1 1 1 0 Nop14-like family AAA PF00004.24 ESA19123.1 - 0.035 14.3 0.0 0.69 10.1 0.0 3.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.20 ESA19124.1 - 1.7e-14 53.6 0.0 2.7e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19124.1 - 7.3e-13 48.1 0.0 9.8e-13 47.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TLD PF07534.11 ESA19125.1 - 1.9e-08 34.4 1.8 2.9e-08 33.7 1.2 1.4 1 0 0 1 1 1 1 TLD AAA_12 PF13087.1 ESA19126.1 - 1.4e-35 122.5 1.0 3.1e-35 121.3 0.7 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA19126.1 - 5e-28 98.2 0.3 5e-28 98.2 0.2 3.2 2 2 0 2 2 2 1 AAA domain DUF2075 PF09848.4 ESA19126.1 - 3.8e-07 29.3 4.1 7.9e-05 21.7 0.0 3.3 2 1 1 3 3 3 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 ESA19126.1 - 4e-06 26.4 0.0 8.4e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA19126.1 - 0.00013 21.6 0.0 0.039 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESA19126.1 - 0.00027 21.1 1.0 0.012 15.8 0.0 3.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.10 ESA19126.1 - 0.0012 18.7 0.6 0.014 15.2 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESA19126.1 - 0.01 15.8 0.0 0.06 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 ESA19126.1 - 0.032 14.3 3.8 0.49 10.5 0.0 4.2 4 1 0 4 4 4 0 AAA domain UvrD_C_2 PF13538.1 ESA19126.1 - 0.083 13.0 0.0 0.3 11.2 0.0 2.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_12 PF13087.1 ESA19127.1 - 8.6e-36 123.2 3.4 2.1e-35 121.9 2.3 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA19127.1 - 1.4e-28 100.0 6.2 4.1e-28 98.5 1.7 2.9 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.4 ESA19127.1 - 1e-06 27.9 9.2 0.00013 21.1 0.0 3.7 3 1 0 4 4 4 2 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.1 ESA19127.1 - 3.2e-06 26.7 0.0 6.6e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA19127.1 - 0.0001 21.9 0.0 0.031 13.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 ESA19127.1 - 0.00036 20.4 2.3 0.00046 20.0 0.1 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA PF00004.24 ESA19127.1 - 0.0021 18.2 1.0 0.021 15.0 0.1 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) UvrD-helicase PF00580.16 ESA19127.1 - 0.0042 16.4 12.9 0.043 13.1 6.2 3.8 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.1 ESA19127.1 - 0.0058 16.6 0.0 0.031 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESA19127.1 - 0.012 15.7 0.4 0.7 10.0 0.0 3.4 3 0 0 3 3 3 0 AAA domain Dimer_Tnp_hAT PF05699.9 ESA19128.1 - 3e-16 58.8 0.0 3.2e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Sel1 PF08238.7 ESA19129.1 - 4.1e-46 154.3 14.3 4.4e-10 39.8 0.1 6.2 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA19129.1 - 0.00015 21.5 12.2 0.0014 18.4 0.2 3.9 4 1 1 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA19129.1 - 0.028 14.8 4.4 2.3 8.8 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA19129.1 - 0.31 10.7 23.5 0.12 12.0 0.9 5.1 2 1 2 4 4 4 0 TPR repeat TPR_3 PF07720.7 ESA19129.1 - 0.61 9.9 6.6 48 3.8 0.4 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA19129.1 - 5.5 7.0 12.2 1.9 8.4 1.0 4.5 3 1 2 5 5 5 0 Tetratricopeptide repeat GAPT PF11770.3 ESA19130.1 - 0.087 12.5 0.9 0.11 12.1 0.6 1.1 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) DUF4404 PF14357.1 ESA19130.1 - 0.62 10.5 5.3 10 6.6 2.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) Nop25 PF09805.4 ESA19130.1 - 2.2 8.3 7.0 1.3 9.1 3.7 1.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Asp_protease_2 PF13650.1 ESA19132.1 - 0.00055 20.3 0.0 0.00091 19.6 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.1 ESA19132.1 - 0.0063 16.3 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 ESA19132.1 - 0.0092 15.8 0.0 0.036 13.9 0.0 2.0 1 1 0 1 1 1 1 Retroviral aspartyl protease URO-D PF01208.12 ESA19133.1 - 1.3e-127 425.4 0.0 1.5e-127 425.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) SPC22 PF04573.7 ESA19134.1 - 7.7e-27 93.6 2.6 9e-27 93.4 1.8 1.1 1 0 0 1 1 1 1 Signal peptidase subunit zf-C2H2 PF00096.21 ESA19135.1 - 0.0032 17.7 2.6 0.0084 16.3 1.8 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA19135.1 - 0.014 15.6 2.9 0.038 14.3 2.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger HET PF06985.6 ESA19135.1 - 0.041 14.0 1.8 0.63 10.2 0.0 2.4 2 0 0 2 2 2 0 Heterokaryon incompatibility protein (HET) Ebola_NP PF05505.7 ESA19135.1 - 0.3 9.1 7.9 0.39 8.7 5.5 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein Rota_VP2 PF05087.7 ESA19135.1 - 0.73 7.6 8.7 1 7.2 6.0 1.1 1 0 0 1 1 1 0 Rotavirus VP2 protein Myb_DNA-binding PF00249.26 ESA19136.1 - 1.1e-06 28.5 0.1 1.7e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA19136.1 - 3.2e-05 23.9 0.3 6.2e-05 23.0 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Peptidase_C50 PF03568.12 ESA19137.1 - 4.3e-77 259.3 0.0 5.6e-77 258.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.2 ESA19137.1 - 0.00015 21.0 0.0 0.072 12.2 0.0 2.1 2 0 0 2 2 2 2 CHAT domain TPR_12 PF13424.1 ESA19138.1 - 0.00011 22.0 1.7 0.17 11.8 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA19138.1 - 0.00012 21.7 8.3 0.0003 20.4 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA19138.1 - 0.00015 21.1 10.0 0.00082 18.8 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA19138.1 - 0.0018 17.8 3.4 0.0047 16.5 0.1 2.9 2 1 0 2 2 2 1 TPR repeat TPR_8 PF13181.1 ESA19138.1 - 0.0044 16.7 0.5 0.0044 16.7 0.3 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA19138.1 - 0.031 14.5 0.1 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA19138.1 - 0.045 13.5 0.1 0.59 10.0 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA19138.1 - 0.19 11.7 0.1 0.65 10.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA19138.1 - 1.4 9.1 15.0 0.48 10.5 5.3 3.8 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Ras PF00071.17 ESA19139.1 - 5.3e-59 198.2 0.0 6.2e-59 198.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA19139.1 - 3.2e-20 72.8 0.0 5.3e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA19139.1 - 2.7e-18 65.8 0.0 3.3e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 ESA19139.1 - 2.5e-09 36.6 0.0 3e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 ESA19139.1 - 3.4e-07 29.8 0.0 7e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA19139.1 - 5.1e-05 23.2 0.0 6.9e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA19139.1 - 0.026 14.4 0.1 0.056 13.4 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Arch_ATPase PF01637.13 ESA19139.1 - 0.081 12.6 0.1 0.25 10.9 0.1 1.8 1 1 0 1 1 1 0 Archaeal ATPase DUF258 PF03193.11 ESA19139.1 - 0.11 11.6 0.1 0.26 10.4 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PseudoU_synth_2 PF00849.17 ESA19140.1 - 3.3e-06 27.0 0.0 4.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.20 ESA19140.1 - 0.024 14.0 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 0 S4 domain Methyltransf_26 PF13659.1 ESA19141.1 - 4.5e-11 42.8 0.0 6e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA19141.1 - 2.6e-09 36.8 0.1 4.5e-09 36.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 ESA19141.1 - 4.3e-07 29.6 0.0 1.1e-06 28.3 0.0 1.6 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.11 ESA19141.1 - 1.7e-06 27.3 0.0 2.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_25 PF13649.1 ESA19141.1 - 2.4e-06 27.8 0.0 8.4e-06 26.0 0.0 1.8 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA19141.1 - 0.00015 22.3 0.0 0.00025 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA19141.1 - 0.00036 19.9 0.4 0.0014 18.0 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 ESA19141.1 - 0.00045 20.6 0.0 0.001 19.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Eco57I PF07669.6 ESA19141.1 - 0.0033 17.7 0.4 3 8.2 0.0 2.4 2 0 0 2 2 2 2 Eco57I restriction-modification methylase Methyltransf_10 PF05971.7 ESA19141.1 - 0.012 14.7 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF890) PrmA PF06325.8 ESA19141.1 - 0.016 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 ESA19141.1 - 0.078 13.4 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Pkinase_Tyr PF07714.12 ESA19144.1 - 1.5e-06 27.5 0.2 6.1e-06 25.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase SF3a60_bindingd PF12108.3 ESA19144.1 - 0.019 14.4 1.6 0.069 12.7 1.1 2.1 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain Pkinase PF00069.20 ESA19144.1 - 0.025 13.7 0.0 0.086 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain Melibiase PF02065.13 ESA19145.1 - 2.5e-24 85.6 1.9 5e-19 68.2 0.0 2.6 2 1 0 2 2 2 2 Melibiase GerA PF03323.8 ESA19145.1 - 0.11 10.6 0.0 0.15 10.1 0.0 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein DUF2052 PF09747.4 ESA19146.1 - 4.4e-32 111.4 29.7 1.3e-31 109.9 19.7 2.1 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) Melibiase PF02065.13 ESA19147.1 - 2.4e-24 85.7 0.1 2.6e-16 59.2 0.0 2.8 2 1 0 2 2 2 2 Melibiase Glyco_hydro_97 PF10566.4 ESA19147.1 - 0.0006 19.0 0.3 0.0021 17.2 0.0 1.8 2 0 0 2 2 2 1 Glycoside hydrolase 97 DUF3896 PF13035.1 ESA19148.1 - 0.028 14.4 2.1 0.033 14.2 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Band_7 PF01145.20 ESA19149.1 - 9.8e-24 84.2 5.2 1.4e-23 83.7 2.6 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 ESA19149.1 - 0.067 12.6 0.4 0.31 10.5 0.0 1.9 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus MT0933_antitox PF14013.1 ESA19149.1 - 5.6 7.1 6.0 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 MT0933-like antitoxin protein DUF684 PF05075.9 ESA19154.1 - 0.083 11.4 0.1 0.099 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF684) DUF4056 PF13265.1 ESA19155.1 - 0.051 12.5 0.0 0.11 11.4 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4056) DUF3589 PF12141.3 ESA19156.1 - 0.0095 14.2 1.3 0.01 14.1 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) DUF1547 PF07577.6 ESA19156.1 - 0.19 11.4 2.0 0.37 10.4 1.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1547) Pkinase_Tyr PF07714.12 ESA19157.1 - 0.00096 18.2 0.9 0.0015 17.6 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase PrpF PF04303.8 ESA19157.1 - 0.018 13.7 0.0 0.023 13.4 0.0 1.1 1 0 0 1 1 1 0 PrpF protein Ax_dynein_light PF10211.4 ESA19157.1 - 0.14 11.9 1.7 4.3 7.1 0.4 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain SART-1 PF03343.8 ESA19159.1 - 3.3e-96 323.0 54.0 4.1e-96 322.6 37.4 1.1 1 0 0 1 1 1 1 SART-1 family TAN PF11640.3 ESA19161.1 - 0.0013 18.4 0.2 0.0026 17.4 0.1 1.5 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair DUF387 PF04079.11 ESA19161.1 - 0.025 13.9 0.1 0.031 13.6 0.1 1.1 1 0 0 1 1 1 0 Putative transcriptional regulators (Ypuh-like) Polysacc_deac_1 PF01522.16 ESA19164.1 - 1.2e-30 105.7 0.0 1.6e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA19164.1 - 7.4e-06 25.0 0.0 1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Chitin_bind_1 PF00187.14 ESA19164.1 - 9.3e-05 22.3 17.1 0.00011 22.0 11.0 1.8 1 1 1 2 2 2 1 Chitin recognition protein Baculo_LEF5 PF04838.7 ESA19164.1 - 0.0053 16.5 0.3 0.012 15.4 0.1 1.5 1 1 0 1 1 1 1 Baculoviridae late expression factor 5 DAGK_cat PF00781.19 ESA19165.1 - 8.3e-21 73.7 0.1 1.4e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Microvir_H PF04687.7 ESA19165.1 - 0.082 11.9 0.2 0.14 11.1 0.2 1.3 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) F-box-like PF12937.2 ESA19168.1 - 0.0013 18.3 4.0 0.0014 18.2 0.7 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA19168.1 - 0.0014 18.2 3.7 0.0021 17.6 0.3 2.8 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.2 ESA19168.1 - 4.5 7.0 15.1 7.5 6.2 1.1 4.7 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) 7tm_1 PF00001.16 ESA19170.1 - 5.9e-07 28.8 15.7 8.8e-07 28.3 10.9 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SWIM PF04434.12 ESA19176.1 - 0.13 11.7 1.0 0.24 10.9 0.7 1.4 1 0 0 1 1 1 0 SWIM zinc finger HMG_box PF00505.14 ESA19177.1 - 2.8e-18 65.9 1.5 3.2e-18 65.7 1.0 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA19177.1 - 9.4e-12 45.1 0.7 1e-11 45.0 0.5 1.0 1 0 0 1 1 1 1 HMG-box domain Dimer_Tnp_hAT PF05699.9 ESA19179.1 - 2e-10 40.1 0.5 4.7e-10 38.9 0.2 1.8 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region YcxB PF14317.1 ESA19180.1 - 0.036 13.2 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 YcxB-like protein O-FucT PF10250.4 ESA19181.1 - 0.0082 15.2 0.0 0.009 15.1 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase O-FucT PF10250.4 ESA19182.1 - 1.7e-06 27.4 0.2 2.4e-05 23.5 0.1 2.3 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peptidase_C26 PF07722.8 ESA19182.1 - 0.094 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase C26 Fucokinase PF07959.7 ESA19184.1 - 0.06 11.8 0.1 0.079 11.5 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase Pneumo_att_G PF05539.6 ESA19186.1 - 2.1 7.6 15.9 2.5 7.3 11.0 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Apis_Csd PF11671.3 ESA19187.1 - 0.26 11.0 14.9 0.14 11.9 4.1 2.1 2 0 0 2 2 2 0 Complementary sex determiner protein FAM176 PF14851.1 ESA19187.1 - 0.34 10.5 3.7 0.43 10.2 2.6 1.1 1 0 0 1 1 1 0 FAM176 family Rab5-bind PF09311.6 ESA19188.1 - 0.0094 15.8 0.8 0.0094 15.8 0.5 2.0 2 0 0 2 2 2 1 Rabaptin-like protein UPF0223 PF05256.7 ESA19188.1 - 0.034 14.2 0.5 0.034 14.2 0.4 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0223) SpoU_sub_bind PF08032.7 ESA19188.1 - 0.26 11.4 2.2 6.9 6.9 0.3 2.7 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Apis_Csd PF11671.3 ESA19189.1 - 0.0097 15.7 3.8 0.0097 15.7 2.6 1.6 2 0 0 2 2 2 1 Complementary sex determiner protein TRAP_beta PF05753.9 ESA19190.1 - 0.0026 16.9 0.1 1.9 7.6 0.0 2.3 2 0 0 2 2 2 2 Translocon-associated protein beta (TRAPB) DUF3159 PF11361.3 ESA19190.1 - 0.021 14.2 3.8 0.028 13.9 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3159) Ribosomal_L2_C PF03947.13 ESA19191.1 - 5.7e-21 74.6 0.1 9.4e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 ESA19191.1 - 5.2e-09 35.9 0.0 1.2e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WD40 PF00400.27 ESA19191.1 - 0.0046 16.7 0.2 0.031 14.1 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat PHD PF00628.24 ESA19192.1 - 8.6e-07 28.5 2.8 1.1e-06 28.1 1.9 1.2 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.1 ESA19192.1 - 0.0045 16.3 1.1 0.0057 15.9 0.7 1.4 1 1 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.1 ESA19192.1 - 0.011 15.0 4.1 0.029 13.6 2.9 1.7 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.6 ESA19192.1 - 0.017 15.1 1.3 0.017 15.1 0.9 1.5 1 1 0 1 1 1 0 RING-like domain C1_1 PF00130.17 ESA19192.1 - 0.055 13.2 1.0 0.055 13.2 0.7 1.6 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RINGv PF12906.2 ESA19192.1 - 0.28 11.2 3.1 0.52 10.4 2.2 1.4 1 1 0 1 1 1 0 RING-variant domain DUF4206 PF13901.1 ESA19192.1 - 0.3 10.6 3.1 0.38 10.2 2.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4206) Phage_Integr_2 PF13009.1 ESA19194.1 - 0.00077 18.4 2.1 0.0013 17.7 1.4 1.3 1 0 0 1 1 1 1 Putative phage integrase Fucokinase PF07959.7 ESA19194.1 - 0.036 12.6 0.0 0.077 11.5 0.0 1.4 1 1 0 1 1 1 0 L-fucokinase Retrotrans_gag PF03732.12 ESA19194.1 - 0.16 12.0 5.6 3.1 7.9 0.6 2.4 2 1 0 2 2 2 0 Retrotransposon gag protein Cyclin PF08613.6 ESA19195.1 - 5.7e-23 81.9 0.0 6.5e-23 81.8 0.0 1.0 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 ESA19195.1 - 0.0014 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Noc2 PF03715.8 ESA19195.1 - 0.015 14.1 0.1 0.018 13.8 0.1 1.0 1 0 0 1 1 1 0 Noc2p family BTB PF00651.26 ESA19197.1 - 1.3e-19 70.1 0.1 1.3e-18 67.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA19197.1 - 2.4e-09 37.2 0.2 5.6e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA19197.1 - 9.3e-07 28.6 0.5 2.4e-05 24.0 0.1 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB_2 PF02214.17 ESA19197.1 - 0.065 13.4 0.9 3.3 7.9 0.0 3.5 2 2 1 3 3 3 0 BTB/POZ domain DUF3342 PF11822.3 ESA19197.1 - 0.073 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB PF00651.26 ESA19198.1 - 3e-20 72.2 0.1 1.1e-19 70.4 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA19198.1 - 3.6e-09 36.7 3.3 8.4e-09 35.5 2.3 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA19198.1 - 2.7e-06 27.1 0.3 0.0001 22.1 0.0 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF4638 PF15472.1 ESA19200.1 - 1.4 8.4 13.8 1.3 8.5 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) DUF4026 PF13218.1 ESA19201.1 - 0.088 11.6 0.1 0.19 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4026) AIG1 PF04548.11 ESA19202.1 - 9.5e-16 57.5 1.5 9.5e-16 57.5 1.0 2.4 3 0 0 3 3 3 1 AIG1 family MMR_HSR1 PF01926.18 ESA19202.1 - 2.3e-07 30.7 1.2 1.4e-06 28.2 0.9 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA19202.1 - 0.00054 20.2 0.1 0.00054 20.2 0.1 2.4 3 1 0 3 3 2 1 ABC transporter Ras PF00071.17 ESA19202.1 - 0.00065 19.1 1.0 0.0014 18.0 0.1 2.0 2 0 0 2 2 2 1 Ras family DUF258 PF03193.11 ESA19202.1 - 0.00074 18.7 0.1 0.0025 16.9 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Septin PF00735.13 ESA19202.1 - 0.00096 18.2 0.6 0.0024 16.9 0.4 1.7 1 0 0 1 1 1 1 Septin FeoB_N PF02421.13 ESA19202.1 - 0.0033 16.7 0.3 0.0065 15.7 0.2 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B IIGP PF05049.8 ESA19202.1 - 0.0042 15.9 2.6 0.0046 15.8 0.0 2.3 3 1 1 4 4 4 1 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.22 ESA19202.1 - 0.0045 16.4 0.9 0.041 13.3 0.2 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ESA19202.1 - 0.016 14.7 0.1 0.045 13.2 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_5 PF07728.9 ESA19202.1 - 0.041 13.5 0.1 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 ESA19202.1 - 0.069 13.2 1.2 1.9 8.6 0.1 2.9 2 1 1 3 3 2 0 AAA domain Poxvirus_B22R_C PF13168.1 ESA19202.1 - 0.077 12.2 0.2 0.22 10.7 0.0 1.8 2 0 0 2 2 2 0 Poxvirus B22R protein C-terminal Pico_P1A PF02226.11 ESA19202.1 - 0.081 12.6 0.1 0.23 11.2 0.1 1.7 1 0 0 1 1 1 0 Picornavirus coat protein (VP4) AAA_16 PF13191.1 ESA19202.1 - 0.082 12.8 0.1 0.64 9.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 ESA19202.1 - 0.15 12.8 3.1 1.3 9.8 0.4 3.0 2 1 0 2 2 2 0 AAA domain EMP24_GP25L PF01105.19 ESA19202.1 - 0.19 11.4 5.8 4 7.1 0.2 2.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Spectrin PF00435.16 ESA19202.1 - 0.22 11.8 6.7 10 6.4 0.2 3.8 3 0 0 3 3 3 0 Spectrin repeat DUF4298 PF14131.1 ESA19202.1 - 1 9.2 9.2 2.6 7.9 0.4 3.7 4 0 0 4 4 3 0 Domain of unknown function (DUF4298) BLOC1_2 PF10046.4 ESA19202.1 - 4.4 7.4 17.9 0.45 10.6 0.8 4.3 5 0 0 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ribosomal_S20p PF01649.13 ESA19202.1 - 6.3 7.2 7.3 0.62 10.4 0.4 2.8 3 0 0 3 3 3 0 Ribosomal protein S20 Glutaredoxin2_C PF04399.8 ESA19202.1 - 7.8 6.0 8.4 13 5.3 0.2 4.0 4 1 0 4 4 4 0 Glutaredoxin 2, C terminal domain Dynamin_N PF00350.18 ESA19202.1 - 7.9 6.2 12.5 0.26 11.0 0.5 3.7 2 2 0 2 2 2 0 Dynamin family Laminin_II PF06009.7 ESA19202.1 - 9.9 5.9 8.4 3.8 7.2 0.5 3.2 3 0 0 3 3 3 0 Laminin Domain II PX PF00787.19 ESA19203.1 - 7.4e-13 48.2 0.0 1.6e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 PX domain P22_CoatProtein PF11651.3 ESA19203.1 - 0.0073 14.9 0.0 0.009 14.6 0.0 1.1 1 0 0 1 1 1 1 P22 coat protein - gene protein 5 DUF3455 PF11937.3 ESA19203.1 - 0.018 14.9 0.0 0.023 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) TonB_C PF03544.9 ESA19203.1 - 0.078 13.1 0.1 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 Gram-negative bacterial TonB protein C-terminal PIP5K PF01504.13 ESA19204.1 - 7.8e-88 293.8 0.6 1.1e-87 293.3 0.4 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase p450 PF00067.17 ESA19206.1 - 3.3e-38 131.3 0.1 3.5e-38 131.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kelch_4 PF13418.1 ESA19207.1 - 7.6e-13 48.0 7.2 0.00015 21.4 0.1 6.4 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA19207.1 - 9.6e-12 44.7 6.1 0.037 14.1 0.0 6.1 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA19207.1 - 2e-10 40.3 7.7 0.017 15.2 0.1 5.5 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.20 ESA19207.1 - 4.1e-06 26.2 5.4 0.26 10.8 0.1 5.1 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA19207.1 - 0.00033 20.2 0.3 8.2 6.3 0.0 5.3 5 0 0 5 5 5 1 Kelch motif Sec2p PF06428.6 ESA19207.1 - 0.033 14.0 0.7 0.053 13.3 0.5 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p WD40 PF00400.27 ESA19208.1 - 2.8e-53 175.9 23.3 1.3e-09 37.5 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.2 ESA19208.1 - 8.3e-09 35.0 0.0 1.7e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19208.1 - 7.7e-08 31.8 0.1 1.9e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 F-box domain Thioredoxin_6 PF13848.1 ESA19209.1 - 0.11 12.3 0.0 0.11 12.2 0.0 1.0 1 0 0 1 1 1 0 Thioredoxin-like domain MCM_bind PF09739.4 ESA19210.1 - 0.038 13.5 0.0 0.043 13.3 0.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor BTB PF00651.26 ESA19211.1 - 7.5e-12 45.2 0.4 2.1e-11 43.7 0.1 1.7 1 1 1 2 2 2 1 BTB/POZ domain BTB PF00651.26 ESA19212.1 - 1.2e-11 44.5 0.0 2.7e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Raffinose_syn PF05691.7 ESA19213.1 - 1.2e-69 234.7 14.2 3.9e-49 166.8 5.6 3.3 1 1 1 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Melibiase PF02065.13 ESA19213.1 - 1.4e-09 37.1 1.6 1.4e-09 37.1 1.1 2.3 2 1 0 2 2 2 1 Melibiase Auto_anti-p27 PF06677.7 ESA19214.1 - 0.012 15.3 0.0 0.068 12.9 0.0 2.2 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PA28_beta PF02252.13 ESA19215.1 - 0.057 12.8 2.1 0.058 12.8 0.4 1.7 2 0 0 2 2 2 0 Proteasome activator pa28 beta subunit Noelin-1 PF12308.3 ESA19215.1 - 0.71 9.7 4.1 2.6 7.9 0.2 2.4 2 1 0 2 2 2 0 Neurogenesis glycoprotein ALIX_LYPXL_bnd PF13949.1 ESA19215.1 - 1.5 7.7 13.4 0.71 8.7 3.0 2.1 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV MCM_N PF14551.1 ESA19215.1 - 1.7 9.1 8.6 6.2 7.3 4.3 2.6 1 1 1 2 2 2 0 MCM N-terminal domain DUF1948 PF09185.5 ESA19215.1 - 2.5 7.7 7.0 0.14 11.7 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1948) ING PF12998.2 ESA19215.1 - 5.4 7.3 8.4 71 3.7 5.8 2.1 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding zf-CCHC PF00098.18 ESA19216.1 - 2.3e-15 55.6 23.0 1e-05 25.2 2.6 3.7 3 0 0 3 3 3 3 Zinc knuckle GIY-YIG PF01541.19 ESA19216.1 - 1e-06 29.0 0.5 1e-06 29.0 0.3 2.6 2 2 0 2 2 2 1 GIY-YIG catalytic domain zf-CCHC_5 PF14787.1 ESA19216.1 - 6.1e-06 25.6 10.7 0.16 11.4 0.4 3.3 3 0 0 3 3 3 3 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 ESA19216.1 - 6.2e-05 22.5 22.1 0.069 12.8 1.0 4.1 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_3 PF13917.1 ESA19216.1 - 0.00016 21.3 20.2 0.17 11.6 2.0 4.2 2 1 2 4 4 4 3 Zinc knuckle zf-CCHC_2 PF13696.1 ESA19216.1 - 4.6 6.8 14.9 7.1 6.2 0.4 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-UBP PF02148.14 ESA19217.1 - 3e-26 91.3 29.0 1.5e-13 50.6 8.3 2.5 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein DUF501 PF04417.7 ESA19217.1 - 0.041 13.7 0.0 6.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF501) zf-RING_3 PF14369.1 ESA19217.1 - 0.094 12.7 0.1 0.094 12.7 0.1 3.9 4 2 1 5 5 5 0 zinc-finger Zn_Tnp_IS1595 PF12760.2 ESA19217.1 - 0.16 11.8 0.3 0.16 11.8 0.2 4.5 2 2 2 4 4 4 0 Transposase zinc-ribbon domain MSA-2c PF12238.3 ESA19217.1 - 0.29 10.7 1.3 0.39 10.3 0.9 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c PPTA PF01239.17 ESA19217.1 - 1.8 8.0 4.7 9.9 5.7 0.2 2.6 2 0 0 2 2 2 0 Protein prenyltransferase alpha subunit repeat MATH PF00917.21 ESA19218.1 - 7.9e-05 22.8 0.1 0.00013 22.2 0.1 1.3 1 0 0 1 1 1 1 MATH domain Pkinase_Tyr PF07714.12 ESA19219.1 - 7e-06 25.3 0.0 3.6e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19219.1 - 0.0065 15.6 0.1 0.072 12.2 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain DUF970 PF06153.6 ESA19219.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF970) CobT PF06213.7 ESA19220.1 - 0.055 12.5 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CHD5 PF04420.9 ESA19220.1 - 0.075 12.6 0.2 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 CHD5-like protein ATG16 PF08614.6 ESA19220.1 - 0.079 12.7 3.3 0.15 11.8 2.3 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) HR1 PF02185.11 ESA19220.1 - 0.15 11.8 4.8 0.38 10.5 3.3 1.7 1 1 0 1 1 1 0 Hr1 repeat Tropomyosin_1 PF12718.2 ESA19220.1 - 0.57 10.0 6.4 6.2 6.6 0.1 2.2 1 1 0 1 1 1 0 Tropomyosin like IncA PF04156.9 ESA19220.1 - 0.74 9.3 3.4 1 8.8 2.4 1.2 1 0 0 1 1 1 0 IncA protein DUF2411 PF10304.4 ESA19221.1 - 0.22 11.1 0.9 0.79 9.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2411) Pkinase PF00069.20 ESA19223.1 - 2.6e-10 39.8 1.6 1.3e-08 34.2 1.1 2.4 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA19223.1 - 2.2e-09 36.9 0.1 7e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.12 ESA19223.1 - 1e-05 24.7 0.3 0.12 11.4 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.15 ESA19223.1 - 4.9e-05 23.0 0.5 0.00015 21.3 0.4 1.8 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 ESA19223.1 - 0.00022 21.0 0.0 0.00043 20.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sgf11 PF08209.6 ESA19223.1 - 0.17 11.2 1.7 2.6 7.4 0.1 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) UQ_con PF00179.21 ESA19224.1 - 5.5e-44 149.0 0.0 6.2e-44 148.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA19224.1 - 0.0019 17.9 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA19224.1 - 0.019 14.8 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain CUE PF02845.11 ESA19224.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 CUE domain F-box-like PF12937.2 ESA19225.1 - 2.9e-06 26.8 3.5 1.2e-05 24.9 2.4 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19225.1 - 0.033 13.8 3.5 0.16 11.6 2.3 2.4 1 1 0 1 1 1 0 F-box domain Pox_A3L PF05288.6 ESA19225.1 - 0.3 10.8 4.4 0.18 11.5 0.3 2.6 2 1 1 3 3 3 0 Poxvirus A3L Protein Tautomerase_3 PF14832.1 ESA19226.1 - 0.031 14.2 0.3 0.038 14.0 0.2 1.1 1 0 0 1 1 1 0 Putative oxalocrotonate tautomerase enzyme UspB PF10625.4 ESA19226.1 - 0.084 12.6 0.2 2.5 7.9 0.1 2.1 1 1 0 1 1 1 0 Universal stress protein B (UspB) FlaC_arch PF05377.6 ESA19229.1 - 0.6 10.0 3.7 0.22 11.4 0.5 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4398 PF14346.1 ESA19229.1 - 1.1 9.3 7.5 1.6 8.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) DUF904 PF06005.7 ESA19229.1 - 3.3 8.0 11.5 1.1 9.5 1.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF904) APC_CDC26 PF10471.4 ESA19229.1 - 8.8 7.1 11.0 11 6.8 0.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit 1 TLD PF07534.11 ESA19230.1 - 1.1e-10 41.6 0.9 4.5e-10 39.6 0.6 2.1 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA19230.1 - 1.9e-08 34.0 0.3 3.4e-06 26.8 0.1 2.9 2 1 1 3 3 3 2 BTB And C-terminal Kelch SAM_PNT PF02198.11 ESA19231.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Lys-AminoMut_A PF09043.6 ESA19231.1 - 0.086 10.9 0.0 0.24 9.5 0.0 1.7 2 1 0 2 2 2 0 D-Lysine 5,6-aminomutase alpha subunit eRF1_2 PF03464.10 ESA19233.1 - 8.5e-46 155.5 0.1 1.5e-45 154.7 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 ESA19233.1 - 3.8e-40 136.6 0.2 8.1e-40 135.6 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 ESA19233.1 - 1.4e-29 102.3 0.0 3.1e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 1 Flavi_NS2A PF01005.14 ESA19234.1 - 0.071 12.3 0.8 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 Flavivirus non-structural protein NS2A Hum_adeno_E3A PF05393.6 ESA19234.1 - 2.8 7.6 9.8 0.042 13.5 0.8 2.3 2 1 1 3 3 3 0 Human adenovirus early E3A glycoprotein Dimer_Tnp_hAT PF05699.9 ESA19236.1 - 0.0044 16.6 0.2 0.012 15.2 0.1 1.8 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region UPF0180 PF03698.8 ESA19238.1 - 0.037 13.8 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) zf-RING_4 PF14570.1 ESA19239.1 - 0.098 12.2 1.9 0.24 10.9 1.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain VWA_2 PF13519.1 ESA19242.1 - 3.5e-08 33.7 0.0 4.1e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA19242.1 - 9.8e-05 22.1 0.0 0.00013 21.6 0.0 1.4 1 1 0 1 1 1 1 von Willebrand factor type A domain Integrin_beta PF00362.13 ESA19242.1 - 0.0017 17.3 0.0 0.19 10.5 0.0 2.1 2 0 0 2 2 2 2 Integrin, beta chain VWA_2 PF13519.1 ESA19243.1 - 1e-05 25.7 0.0 1.2e-05 25.4 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA19243.1 - 2.3e-05 24.2 0.0 2.5e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_beta PF00362.13 ESA19243.1 - 9.5e-05 21.4 0.0 0.076 11.8 0.0 2.0 1 1 1 2 2 2 2 Integrin, beta chain DUF3684 PF12449.3 ESA19244.1 - 1.8e-228 761.0 0.1 2.8e-223 743.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA19244.1 - 8.8e-07 28.6 0.0 2.7e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA19244.1 - 0.00069 19.3 0.0 0.0021 17.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Epiglycanin_TR PF05647.6 ESA19244.1 - 0.039 13.7 7.0 0.081 12.7 4.9 1.5 1 0 0 1 1 1 0 Tandem-repeating region of mucin, epiglycanin-like DUF371 PF04027.8 ESA19244.1 - 0.057 13.0 0.1 0.18 11.4 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF371) BTB PF00651.26 ESA19246.1 - 1.6e-19 69.9 0.1 2e-19 69.5 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA19246.1 - 0.11 12.5 0.1 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain UPF0020 PF01170.13 ESA19247.1 - 0.023 14.3 0.1 0.025 14.1 0.1 1.1 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 ERF PF04404.7 ESA19247.1 - 0.035 13.6 0.5 0.035 13.6 0.4 1.1 1 0 0 1 1 1 0 ERF superfamily PaaSYMP PF14738.1 ESA19247.1 - 0.071 12.8 1.2 0.082 12.6 0.8 1.2 1 0 0 1 1 1 0 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 UvrD_C PF13361.1 ESA19247.1 - 0.087 12.2 3.2 0.092 12.1 2.2 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TFIIE_beta PF02186.10 ESA19247.1 - 0.25 11.3 1.7 0.51 10.3 1.0 1.7 1 1 0 1 1 1 0 TFIIE beta subunit core domain DUF1132 PF06575.7 ESA19247.1 - 0.64 10.3 3.6 1.1 9.6 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1132) Bestrophin PF01062.16 ESA19248.1 - 4.2e-60 203.1 0.2 2.8e-32 111.8 0.0 2.0 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel START PF01852.14 ESA19249.1 - 4.1e-08 32.8 0.0 7.3e-08 31.9 0.0 1.4 2 0 0 2 2 2 1 START domain Carbpep_Y_N PF05388.6 ESA19250.1 - 0.0093 16.1 0.1 0.035 14.2 0.0 1.8 1 1 1 2 2 2 1 Carboxypeptidase Y pro-peptide MxiH PF09392.5 ESA19250.1 - 0.035 14.6 0.0 0.043 14.3 0.0 1.1 1 0 0 1 1 1 0 Type III secretion needle MxiH like DUF1948 PF09185.5 ESA19250.1 - 0.077 12.6 0.1 0.087 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) DUF4446 PF14584.1 ESA19250.1 - 0.1 12.4 0.1 0.3 10.9 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Ehbp PF10622.4 ESA19250.1 - 0.11 12.5 0.1 5.7 6.9 0.0 2.4 2 1 1 3 3 3 0 Energy-converting hydrogenase B subunit P (EhbP) EzrA PF06160.7 ESA19250.1 - 0.11 10.6 2.4 0.11 10.6 0.1 1.9 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF485 PF04341.7 ESA19250.1 - 0.13 11.9 0.1 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 MttA_Hcf106 PF02416.11 ESA19250.1 - 6.1 6.0 6.8 0.92 8.6 0.0 2.5 3 0 0 3 3 3 0 mttA/Hcf106 family p450 PF00067.17 ESA19251.1 - 1.8e-28 99.3 0.0 2.1e-28 99.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 ESA19252.1 - 4.1e-06 26.4 1.6 4.1e-06 26.4 1.1 1.8 2 0 0 2 2 2 1 F-box-like Transp_Tc5_C PF04236.10 ESA19252.1 - 0.082 13.1 0.8 0.14 12.4 0.5 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain Sel1 PF08238.7 ESA19253.1 - 3.5e-06 27.4 0.1 4.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Sel1 repeat KNOX2 PF03791.8 ESA19253.1 - 0.084 12.1 0.1 0.23 10.7 0.0 1.6 2 0 0 2 2 2 0 KNOX2 domain DUF1722 PF08349.6 ESA19253.1 - 0.099 12.5 0.1 0.1 12.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) Aldo_ket_red PF00248.16 ESA19254.1 - 7e-56 189.1 0.0 1.4e-54 184.8 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family PA14_2 PF10528.4 ESA19255.1 - 0.011 15.7 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 0 GLEYA domain Fasciclin PF02469.17 ESA19257.1 - 3.2e-31 107.9 0.1 4.7e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain Bacteriocin_IId PF09221.5 ESA19257.1 - 0.22 11.4 4.7 0.11 12.4 0.7 2.4 2 0 0 2 2 2 0 Bacteriocin class IId cyclical uberolysin-like BTB PF00651.26 ESA19258.1 - 4.6e-13 49.1 0.2 9.3e-13 48.1 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19258.1 - 6e-10 39.2 8.0 1.4e-09 38.0 3.3 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19258.1 - 1.2e-06 28.3 1.2 1.8e-05 24.4 0.0 3.2 3 1 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA19259.1 - 1.2e-20 73.5 0.0 2e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA19259.1 - 0.0016 18.2 4.8 0.0072 16.1 0.1 3.4 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA19259.1 - 0.023 13.8 0.2 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB PF00651.26 ESA19260.1 - 1.2e-17 63.8 0.0 2.6e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19260.1 - 2.6e-09 37.1 2.2 2.6e-09 37.1 1.5 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19260.1 - 1.1e-07 31.5 0.5 1.1e-07 31.5 0.4 3.2 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF919 PF06034.6 ESA19262.1 - 0.05 13.2 1.8 0.15 11.7 0.4 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) PA26 PF04636.8 ESA19263.1 - 1.1 7.9 8.2 1.6 7.3 5.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BCS1_N PF08740.6 ESA19264.1 - 2.2e-49 167.6 0.5 3.4e-49 166.9 0.3 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 ESA19264.1 - 5.8e-20 71.8 0.0 9.3e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA19264.1 - 3.3e-06 27.8 0.0 1.3e-05 26.0 0.0 2.0 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.8 ESA19264.1 - 5.1e-05 22.3 0.0 9.7e-05 21.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.1 ESA19264.1 - 0.00064 20.0 0.0 0.0057 16.9 0.0 2.6 2 2 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA19264.1 - 0.00094 19.3 0.0 0.0032 17.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESA19264.1 - 0.0011 18.8 0.0 0.0028 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESA19264.1 - 0.0017 18.1 0.0 0.0035 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_21 PF13304.1 ESA19264.1 - 0.0019 18.2 0.9 0.011 15.7 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 ESA19264.1 - 0.0025 17.8 0.0 0.01 15.8 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_25 PF13481.1 ESA19264.1 - 0.0027 17.1 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 ESA19264.1 - 0.003 17.0 0.0 0.0064 15.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.17 ESA19264.1 - 0.0032 17.6 0.0 0.0089 16.1 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_23 PF13476.1 ESA19264.1 - 0.012 15.9 1.9 0.22 11.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.1 ESA19264.1 - 0.014 15.2 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 ESA19264.1 - 0.016 15.4 0.0 0.028 14.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.7 ESA19264.1 - 0.021 13.9 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.7 ESA19264.1 - 0.026 13.5 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus Miro PF08477.8 ESA19264.1 - 0.036 14.5 0.0 0.18 12.3 0.0 2.2 3 0 0 3 3 2 0 Miro-like protein Arch_ATPase PF01637.13 ESA19264.1 - 0.059 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_24 PF13479.1 ESA19264.1 - 0.073 12.6 0.0 0.28 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 ESA19264.1 - 0.076 12.1 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 KaiC MMR_HSR1 PF01926.18 ESA19264.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.7 ESA19264.1 - 0.093 12.3 0.0 0.68 9.5 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_19 PF13245.1 ESA19264.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain TPP_enzyme_N PF02776.13 ESA19265.1 - 1.7e-55 187.1 0.1 1.7e-54 183.8 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 ESA19265.1 - 1.1e-35 122.3 0.0 2.6e-35 121.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 ESA19265.1 - 2.1e-28 98.8 0.0 7.8e-28 96.9 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 ESA19265.1 - 0.0036 16.2 0.3 0.0061 15.5 0.2 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase CO_dh PF02552.11 ESA19265.1 - 0.036 13.6 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Brr6_like_C_C PF10104.4 ESA19266.1 - 1.4e-27 95.8 7.8 1.8e-27 95.4 5.4 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Cation_ATPase_C PF00689.16 ESA19266.1 - 0.0087 15.5 0.2 0.018 14.5 0.1 1.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus ARD PF03079.9 ESA19267.1 - 4.1e-47 160.0 0.2 4.8e-47 159.8 0.2 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 ESA19267.1 - 1.5e-09 37.1 0.0 3.3e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 ESA19267.1 - 2.8e-05 23.7 0.0 5.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.17 ESA19267.1 - 0.0026 17.2 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 Cupin Pkinase_Tyr PF07714.12 ESA19269.1 - 6e-32 110.7 0.0 2.1e-27 95.8 0.0 3.6 3 1 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA19269.1 - 7.3e-31 107.2 0.5 1.6e-30 106.1 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain CAF1 PF04857.15 ESA19269.1 - 0.00024 20.5 4.6 0.33 10.2 0.1 4.0 4 0 0 4 4 4 2 CAF1 family ribonuclease DUF2373 PF10180.4 ESA19269.1 - 0.00042 19.8 16.6 2 8.0 0.2 4.7 4 0 0 4 4 4 4 Uncharacterised conserved protein (DUF2373) BACK PF07707.10 ESA19269.1 - 0.097 12.5 0.8 1.2 8.9 0.1 2.9 3 0 0 3 3 3 0 BTB And C-terminal Kelch BBS2_Mid PF14783.1 ESA19269.1 - 0.17 11.7 2.8 9.7 6.0 0.1 2.7 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF72 PF01904.13 ESA19269.1 - 3.3 7.3 14.7 11 5.6 0.1 4.2 3 1 1 4 4 4 0 Protein of unknown function DUF72 TetR_C_5 PF08360.6 ESA19270.1 - 0.038 13.9 0.3 0.64 9.9 0.1 2.1 2 0 0 2 2 2 0 QacR-like protein, C-terminal region DUF3772 PF12607.3 ESA19271.1 - 0.23 11.1 0.7 0.29 10.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) SPRY PF00622.23 ESA19274.1 - 1.3e-08 34.9 0.3 2.6e-08 33.9 0.2 1.5 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA19274.1 - 0.00027 20.9 0.9 0.0015 18.5 0.2 2.5 2 1 1 3 3 3 1 BTB/POZ domain DUF851 PF05867.6 ESA19276.1 - 0.078 12.2 0.0 0.081 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF851) BTB PF00651.26 ESA19277.1 - 1.3e-06 28.4 0.2 3.5e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA19277.1 - 6.4e-05 22.9 0.2 0.00035 20.5 0.1 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19277.1 - 0.00064 19.5 2.6 0.0024 17.6 0.6 2.6 1 1 2 3 3 3 1 BTB And C-terminal Kelch HALZ PF02183.13 ESA19278.1 - 0.098 12.3 3.5 0.1 12.3 0.5 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUSP PF06337.7 ESA19278.1 - 0.1 13.0 1.3 0.49 10.8 0.2 2.4 2 1 0 2 2 2 0 DUSP domain Utp21 PF04192.7 ESA19279.1 - 1.2e-69 234.0 8.0 1.8e-69 233.4 5.5 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 ESA19279.1 - 2.3e-25 87.5 22.4 4.4e-08 32.7 0.4 9.2 10 0 0 10 10 10 6 WD domain, G-beta repeat Nup160 PF11715.3 ESA19279.1 - 7.2e-05 21.1 2.0 0.22 9.6 0.0 3.8 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 ESA19279.1 - 0.023 13.0 0.1 0.74 8.0 0.0 2.9 2 1 1 3 3 3 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.4 ESA19279.1 - 6 6.2 6.5 4.5 6.6 0.1 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature BTB PF00651.26 ESA19281.1 - 1.4e-13 50.7 0.0 2.4e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA19281.1 - 4e-05 23.3 0.2 0.00012 21.8 0.1 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch HTH_Mga PF08280.6 ESA19281.1 - 0.17 11.6 2.1 0.56 10.0 0.4 2.4 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain API5 PF05918.6 ESA19281.1 - 4.5 5.6 8.3 15 3.9 0.0 2.3 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) Band_7 PF01145.20 ESA19284.1 - 0.0027 17.6 0.2 0.0043 16.9 0.1 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family NAD_binding_5 PF07994.7 ESA19285.1 - 2.2e-112 375.3 0.1 2.5e-112 375.1 0.1 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 ESA19285.1 - 8.3e-46 154.4 0.0 1.4e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase DUF1133 PF06576.6 ESA19287.1 - 0.018 14.1 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) zf-BED PF02892.10 ESA19287.1 - 0.13 12.0 2.0 5.5 6.8 0.1 2.5 2 1 0 2 2 2 0 BED zinc finger Toxin_57 PF15535.1 ESA19290.1 - 0.00064 19.7 0.1 0.00085 19.3 0.1 1.1 1 0 0 1 1 1 1 Putative toxin 57 Pkinase_Tyr PF07714.12 ESA19291.1 - 0.014 14.5 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase KRAP_IP3R_bind PF14722.1 ESA19291.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain Pkinase_Tyr PF07714.12 ESA19292.1 - 1e-08 34.5 0.0 1.7e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19292.1 - 1.5e-05 24.3 0.0 2.9e-05 23.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain BTB PF00651.26 ESA19294.1 - 2e-06 27.7 0.0 2.6e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA19295.1 - 3.4e-15 56.0 0.0 7.5e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19295.1 - 1.3e-09 38.2 0.9 3.5e-09 36.7 0.2 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19295.1 - 3.6e-08 33.1 4.3 8e-06 25.6 0.2 4.1 3 1 1 4 4 4 1 BTB And C-terminal Kelch RPM2 PF08579.6 ESA19295.1 - 0.014 15.5 3.4 0.03 14.4 0.1 2.7 1 1 1 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) DUF3342 PF11822.3 ESA19295.1 - 0.016 14.3 0.2 0.027 13.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB PF00651.26 ESA19297.1 - 2.8e-10 40.1 1.3 5.5e-10 39.2 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA19297.1 - 4.4e-08 33.2 1.3 4.4e-08 33.2 0.9 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19297.1 - 1.9e-06 27.6 3.2 0.00018 21.3 0.3 4.0 4 1 1 5 5 5 1 BTB And C-terminal Kelch Dimer_Tnp_hAT PF05699.9 ESA19299.1 - 6.8e-05 22.4 0.1 0.00014 21.3 0.1 1.6 1 1 0 1 1 1 1 hAT family C-terminal dimerisation region Dimer_Tnp_hAT PF05699.9 ESA19300.1 - 3.7e-10 39.2 0.1 4e-10 39.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region TLD PF07534.11 ESA19305.1 - 1.1e-10 41.6 1.2 1.1e-10 41.6 0.8 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19305.1 - 1.2e-06 28.3 0.4 3.1e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch BACK PF07707.10 ESA19306.1 - 6e-06 26.0 2.1 2.6e-05 23.9 0.3 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch TisB_toxin PF13939.1 ESA19306.1 - 3.7 7.3 6.2 12 5.7 0.3 2.5 2 0 0 2 2 2 0 Toxin TisB, type I toxin-antitoxin system TACC PF05010.9 ESA19307.1 - 0.14 11.8 1.6 0.17 11.6 1.1 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) Pkinase_Tyr PF07714.12 ESA19308.1 - 8.1e-25 87.3 0.1 1.1e-24 86.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19308.1 - 5.1e-21 74.9 6.1 1.6e-20 73.3 4.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA19308.1 - 0.024 13.7 0.1 0.047 12.7 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BCDHK_Adom3 PF10436.4 ESA19308.1 - 0.042 13.3 0.0 0.054 12.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase APH PF01636.18 ESA19308.1 - 0.047 13.4 1.4 0.071 12.8 1.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4441 PF14536.1 ESA19308.1 - 2.7 7.9 13.2 0.071 13.0 1.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) TRF PF08558.5 ESA19311.1 - 0.037 13.3 2.5 0.052 12.8 1.7 1.4 1 1 0 1 1 1 0 Telomere repeat binding factor (TRF) YqzH PF14164.1 ESA19311.1 - 0.087 12.7 1.7 0.49 10.3 0.3 2.3 2 0 0 2 2 2 0 YqzH-like protein SAP PF02037.22 ESA19311.1 - 0.38 10.3 0.0 0.38 10.3 0.0 3.2 4 0 0 4 4 4 0 SAP domain Ran-binding PF05508.6 ESA19312.1 - 0.051 12.4 0.1 0.1 11.4 0.0 1.5 1 1 0 1 1 1 0 RanGTP-binding protein MRF_C2 PF13888.1 ESA19313.1 - 0.067 12.9 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Myelin gene regulatory factor C-terminal domain 2 Pkinase_Tyr PF07714.12 ESA19314.1 - 2.9e-42 144.5 0.0 4.7e-42 143.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19314.1 - 5.9e-40 137.0 3.3 7.5e-40 136.7 1.1 2.0 2 1 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA19314.1 - 0.0023 17.0 0.1 0.0044 16.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA19314.1 - 0.013 14.4 0.0 0.023 13.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA19314.1 - 0.023 14.4 0.1 0.038 13.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Methyltransf_23 PF13489.1 ESA19314.1 - 0.1 12.3 0.0 0.45 10.2 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.20 ESA19315.1 - 2.1e-32 112.2 0.4 6.2e-32 110.7 0.3 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19315.1 - 1.6e-29 102.7 0.0 2e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PsbU PF06514.6 ESA19315.1 - 0.029 14.1 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) APH PF01636.18 ESA19315.1 - 0.047 13.4 0.1 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA19316.1 - 2.6e-31 108.6 0.0 4.5e-31 107.8 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19316.1 - 5.4e-30 104.3 0.1 8.7e-30 103.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA19316.1 - 0.0037 17.0 0.1 0.0055 16.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family BACK PF07707.10 ESA19317.1 - 1.7e-06 27.8 0.6 8.3e-06 25.5 0.1 2.2 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA19318.1 - 2e-05 24.5 0.0 2.3e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19319.1 - 1.3e-14 54.3 1.6 1.3e-14 54.3 1.1 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19319.1 - 7.1e-07 29.0 0.9 3.6e-06 26.7 0.3 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch RNase_PH PF01138.16 ESA19320.1 - 1.1e-20 74.2 0.1 1.6e-20 73.7 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESA19320.1 - 3.8e-07 29.9 0.0 1.3e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 F-box-like PF12937.2 ESA19321.1 - 0.0055 16.4 0.1 0.015 15.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like Tax PF02959.11 ESA19322.1 - 0.067 12.6 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 HTLV Tax Sarcolipin PF05366.6 ESA19324.1 - 0.36 10.2 2.9 3.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Sarcolipin F-box PF00646.28 ESA19325.1 - 0.0013 18.2 2.8 0.0016 18.0 0.2 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 ESA19325.1 - 0.01 15.5 1.2 0.019 14.6 0.1 1.9 2 0 0 2 2 2 0 F-box-like Nramp PF01566.13 ESA19326.1 - 7.2e-119 396.7 17.9 7.2e-119 396.7 12.4 1.3 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein SAM_1 PF00536.25 ESA19328.1 - 0.0019 18.3 0.3 0.0071 16.5 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DivIC PF04977.10 ESA19328.1 - 0.003 16.9 3.5 0.009 15.4 2.5 1.8 1 0 0 1 1 1 1 Septum formation initiator SAM_2 PF07647.12 ESA19328.1 - 0.0071 16.1 0.1 0.023 14.5 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ADIP PF11559.3 ESA19328.1 - 0.0097 15.8 1.2 0.018 14.9 0.8 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF904 PF06005.7 ESA19328.1 - 0.16 12.2 4.0 0.58 10.4 2.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Pkinase PF00069.20 ESA19329.1 - 1.2e-22 80.2 0.0 2.2e-22 79.4 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19329.1 - 1.1e-21 77.1 0.0 1.4e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA19329.1 - 0.082 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family NMD3 PF04981.8 ESA19333.1 - 0.085 11.9 2.0 0.16 11.0 0.9 1.7 1 1 0 1 1 1 0 NMD3 family TLD PF07534.11 ESA19334.1 - 5.8e-11 42.5 0.3 5.8e-11 42.5 0.2 2.2 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA19334.1 - 8.5e-09 35.3 0.1 1.5e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA19334.1 - 0.015 14.4 0.1 0.037 13.1 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) BACK PF07707.10 ESA19334.1 - 0.03 14.1 1.7 0.072 12.9 0.1 2.4 2 1 1 3 3 3 0 BTB And C-terminal Kelch Collagen PF01391.13 ESA19335.1 - 4.7e-06 26.0 12.5 4.7e-06 26.0 8.7 2.7 3 0 0 3 3 3 2 Collagen triple helix repeat (20 copies) Phage_lysozyme PF00959.14 ESA19336.1 - 1.4e-08 34.9 0.0 1.8e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme VanY PF02557.12 ESA19338.1 - 0.081 12.7 0.3 18 5.2 0.0 2.7 3 0 0 3 3 3 0 D-alanyl-D-alanine carboxypeptidase CTP_transf_2 PF01467.21 ESA19339.1 - 0.081 12.9 0.0 3.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Cytidylyltransferase CO_dh PF02552.11 ESA19340.1 - 0.037 13.5 0.3 0.041 13.4 0.2 1.1 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Phospholip_A2_2 PF05826.7 ESA19341.1 - 0.14 12.1 1.0 0.37 10.7 0.7 1.7 1 0 0 1 1 1 0 Phospholipase A2 BTB PF00651.26 ESA19342.1 - 3.7e-08 33.3 0.0 4.5e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DDHD PF02862.12 ESA19348.1 - 8.3e-52 176.2 0.2 6e-51 173.4 0.0 2.0 2 0 0 2 2 2 1 DDHD domain WWE PF02825.15 ESA19348.1 - 0.00057 19.2 0.0 0.56 9.6 0.0 2.8 3 0 0 3 3 3 2 WWE domain RNase_H PF00075.19 ESA19349.1 - 0.00074 19.8 0.0 0.0024 18.1 0.0 1.9 2 0 0 2 2 2 1 RNase H CitF PF04223.7 ESA19349.1 - 0.031 12.9 0.0 0.067 11.8 0.0 1.5 1 0 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) Phospholip_A2_2 PF05826.7 ESA19349.1 - 0.19 11.7 1.9 0.48 10.4 1.3 1.7 1 0 0 1 1 1 0 Phospholipase A2 RNase_H PF00075.19 ESA19350.1 - 0.0043 17.3 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 RNase H Pkinase_Tyr PF07714.12 ESA19351.1 - 9.7e-25 87.1 0.0 1.6e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19351.1 - 2.8e-22 79.1 0.0 3.8e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-B_box PF00643.19 ESA19351.1 - 0.32 10.9 3.5 0.61 10.0 2.4 1.4 1 0 0 1 1 1 0 B-box zinc finger HMG_box PF00505.14 ESA19352.1 - 2.4e-08 34.1 0.4 2.4e-08 34.1 0.3 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA19352.1 - 0.0017 18.6 1.5 0.0031 17.8 0.3 1.9 2 0 0 2 2 2 1 HMG-box domain MAT_Alpha1 PF04769.7 ESA19352.1 - 0.035 13.4 0.3 0.046 13.0 0.2 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 PAXIP1_C PF15364.1 ESA19352.1 - 2.8 7.8 7.4 2.8 7.8 0.9 2.5 2 1 1 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein ABC_membrane PF00664.18 ESA19353.1 - 3e-111 371.2 43.7 3.2e-56 190.7 15.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA19353.1 - 2.4e-73 244.9 0.0 3.1e-35 121.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 ESA19353.1 - 1.7e-15 56.8 4.3 1.1e-05 24.7 0.0 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 ESA19353.1 - 9e-12 45.5 3.5 0.11 12.4 0.0 5.3 3 2 1 5 5 4 4 AAA domain ABC_ATPase PF09818.4 ESA19353.1 - 2.4e-08 33.0 1.6 0.00013 20.6 0.0 2.6 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.1 ESA19353.1 - 2e-07 31.1 0.7 0.03 14.3 0.0 2.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 ESA19353.1 - 2.1e-07 30.3 2.2 0.0019 17.6 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 ESA19353.1 - 3.3e-06 26.3 0.0 0.066 12.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA19353.1 - 3.4e-06 27.8 0.0 0.084 13.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 ESA19353.1 - 3.5e-06 27.2 3.5 3.7 7.7 0.7 4.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA19353.1 - 8.5e-05 22.7 4.1 0.35 11.0 0.2 4.4 2 2 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 ESA19353.1 - 0.00011 22.0 2.9 0.14 12.0 0.1 3.3 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 ESA19353.1 - 0.00013 21.3 0.3 0.73 9.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 ESA19353.1 - 0.00077 19.0 0.3 1.4 8.4 0.1 3.6 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.1 ESA19353.1 - 0.0017 18.2 0.0 1.4 8.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 ESA19353.1 - 0.002 17.8 0.3 4 7.1 0.0 3.5 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 ESA19353.1 - 0.0021 17.2 0.2 1.9 7.5 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA_23 PF13476.1 ESA19353.1 - 0.0063 16.8 8.6 0.16 12.2 0.0 4.2 5 0 0 5 5 4 1 AAA domain AAA_18 PF13238.1 ESA19353.1 - 0.0065 16.7 0.0 4.7 7.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA19353.1 - 0.0068 16.5 0.2 1.7 8.8 0.0 3.4 3 0 0 3 3 2 1 RNA helicase MobB PF03205.9 ESA19353.1 - 0.0095 15.6 1.1 1.6 8.4 0.1 3.1 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 ESA19353.1 - 0.0098 15.6 0.1 2.9 7.7 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain NB-ARC PF00931.17 ESA19353.1 - 0.021 13.6 0.1 1.2 7.9 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.12 ESA19353.1 - 0.03 14.1 4.4 0.49 10.1 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function DUF87 FtsK_SpoIIIE PF01580.13 ESA19353.1 - 0.032 13.6 0.7 0.062 12.7 0.0 1.8 2 0 0 2 2 1 0 FtsK/SpoIIIE family Dala_Dala_lig_N PF01820.16 ESA19353.1 - 0.037 14.3 0.2 0.15 12.3 0.0 2.2 2 0 0 2 2 1 0 D-ala D-ala ligase N-terminus MMR_HSR1 PF01926.18 ESA19353.1 - 0.12 12.3 1.5 9.9 6.1 0.0 3.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.2 ESA19353.1 - 0.22 10.8 6.8 6 6.2 0.0 3.8 4 0 0 4 4 4 0 AAA-like domain RNase_H PF00075.19 ESA19354.1 - 4.3e-05 23.8 0.2 0.00017 21.9 0.0 2.0 2 0 0 2 2 2 1 RNase H zf-CCHC PF00098.18 ESA19355.1 - 7e-05 22.5 0.9 0.00011 21.9 0.6 1.4 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.3 ESA19355.1 - 0.043 13.7 0.1 0.12 12.2 0.1 1.9 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G F-box-like PF12937.2 ESA19356.1 - 4.9e-06 26.1 6.6 7.6e-06 25.5 3.3 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA19356.1 - 0.06 13.0 2.3 0.17 11.5 0.9 2.5 2 0 0 2 2 2 0 F-box domain TA0956 PF11513.3 ESA19356.1 - 0.25 11.3 0.0 0.25 11.3 0.0 3.3 5 0 0 5 5 5 0 Thermoplasma acidophilum protein TA0956 Abhydrolase_3 PF07859.8 ESA19357.1 - 1.9e-38 132.1 0.0 2.1e-32 112.4 0.0 2.7 2 1 0 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA19357.1 - 3.8e-09 35.6 0.0 6.1e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA19357.1 - 1.2e-07 31.6 0.0 1.8e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESA19358.1 - 5.6e-39 133.8 0.1 5.5e-32 111.0 0.0 3.0 2 1 1 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA19358.1 - 7.4e-09 34.7 0.0 1.2e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA19358.1 - 3.8e-08 33.1 0.0 5.7e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESA19359.1 - 9.6e-08 31.8 0.0 1.1e-05 25.1 0.0 2.9 2 1 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_M48 PF01435.13 ESA19360.1 - 1.3e-35 123.0 0.0 2.5e-35 122.0 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M48 SLBP_RNA_bind PF15247.1 ESA19360.1 - 0.023 14.4 0.1 0.082 12.6 0.0 2.0 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain F-box-like PF12937.2 ESA19364.1 - 0.0019 17.8 0.2 0.008 15.8 0.1 2.1 1 0 0 1 1 1 1 F-box-like CRAM_rpt PF07016.6 ESA19365.1 - 0.52 9.6 5.5 0.78 9.1 3.8 1.2 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor TLD PF07534.11 ESA19366.1 - 1.9e-07 31.1 0.2 3.6e-05 23.7 0.0 2.8 2 0 0 2 2 2 2 TLD RasGEF_N PF00618.15 ESA19366.1 - 0.0032 17.5 1.0 0.01 15.9 0.1 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif BACK PF07707.10 ESA19366.1 - 0.016 15.0 3.4 0.36 10.6 0.2 3.5 3 2 1 4 4 4 0 BTB And C-terminal Kelch DUF1019 PF06254.6 ESA19366.1 - 0.071 13.2 0.0 0.24 11.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1019) DUF4325 PF14213.1 ESA19366.1 - 0.26 10.9 2.0 0.34 10.5 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4325) zf-H2C2_5 PF13909.1 ESA19367.1 - 0.066 13.4 1.0 0.066 13.4 0.7 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF818 PF05677.7 ESA19368.1 - 0.029 13.1 0.0 0.033 12.9 0.0 1.0 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Retrotrans_gag PF03732.12 ESA19369.1 - 0.12 12.4 2.5 24 5.0 0.0 3.6 4 0 0 4 4 4 0 Retrotransposon gag protein Asp_protease PF09668.5 ESA19370.1 - 0.0025 17.3 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease_2 PF13650.1 ESA19370.1 - 0.0085 16.5 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease AAA_13 PF13166.1 ESA19372.1 - 0.04 12.3 23.8 0.0073 14.8 10.2 2.0 2 0 0 2 2 2 0 AAA domain Rop-like PF05082.8 ESA19372.1 - 0.046 13.1 9.4 0.72 9.3 1.3 3.3 2 1 0 2 2 2 0 Rop-like Fib_alpha PF08702.5 ESA19372.1 - 1.9 8.5 20.7 0.29 11.2 7.9 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF106 PF01956.11 ESA19372.1 - 2.2 7.7 9.1 1.3e+02 2.0 6.3 2.9 1 1 0 1 1 1 0 Integral membrane protein DUF106 DUF730 PF05325.6 ESA19372.1 - 3.7 7.3 6.8 0.92 9.3 0.4 2.7 2 1 2 4 4 4 0 Protein of unknown function (DUF730) Abhydrolase_3 PF07859.8 ESA19375.1 - 2.8e-08 33.5 0.0 6.5e-05 22.5 0.0 2.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold FAR1 PF03101.10 ESA19377.1 - 1e-05 25.9 2.9 1e-05 25.9 2.0 2.6 2 1 1 3 3 3 2 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA19377.1 - 0.004 16.6 10.1 0.043 13.3 4.3 2.7 1 1 1 2 2 2 2 MuDR family transposase Sec20 PF03908.8 ESA19377.1 - 0.1 12.3 6.5 5 6.8 0.3 3.7 3 0 0 3 3 3 0 Sec20 CobT PF06213.7 ESA19377.1 - 3.3 6.7 15.7 5.8 5.9 10.9 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sec63 PF02889.11 ESA19379.1 - 0.0012 18.1 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Adaptin_N PF01602.15 ESA19380.1 - 1.1e-125 419.9 11.0 1.4e-125 419.5 7.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 ESA19380.1 - 6e-40 135.7 0.0 2.5e-39 133.7 0.0 2.1 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 ESA19380.1 - 2.6e-18 66.4 1.8 5.9e-18 65.2 0.8 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain MAM33 PF02330.11 ESA19381.1 - 2.1e-36 125.5 4.9 2.7e-36 125.2 3.4 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein EF-hand_1 PF00036.27 ESA19382.1 - 1.6e-26 89.5 6.3 9.2e-08 30.8 0.0 5.6 5 1 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 ESA19382.1 - 8.8e-23 80.2 1.4 8.5e-09 35.4 2.9 4.1 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 ESA19382.1 - 4.6e-22 75.8 6.0 4.1e-07 29.3 0.1 4.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 ESA19382.1 - 1.6e-20 71.4 1.9 9.3e-06 24.7 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 ESA19382.1 - 9.2e-18 63.6 3.2 2.6e-08 33.3 0.0 4.4 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_9 PF14658.1 ESA19382.1 - 0.0038 17.1 0.0 0.56 10.1 0.0 3.3 3 1 0 3 3 3 1 EF-hand domain Toprim_2 PF13155.1 ESA19382.1 - 0.01 16.1 0.2 10 6.5 0.0 3.3 1 1 2 3 3 3 0 Toprim-like SPARC_Ca_bdg PF10591.4 ESA19382.1 - 0.017 15.1 0.2 4.6 7.3 0.0 2.9 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 ESA19382.1 - 0.057 13.0 0.0 16 5.2 0.0 2.9 3 0 0 3 3 3 0 EF hand Pro-rich PF15240.1 ESA19382.1 - 0.7 9.9 30.5 1 9.4 21.1 1.1 1 0 0 1 1 1 0 Proline-rich RRM_5 PF13893.1 ESA19383.1 - 2.7e-07 30.3 0.0 5.1e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA19383.1 - 0.0019 17.7 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA19383.1 - 0.029 14.3 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) FA_desaturase PF00487.19 ESA19384.1 - 7.5e-17 61.6 18.1 7.5e-17 61.6 12.5 1.7 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 ESA19384.1 - 3.3e-16 58.8 0.0 6.7e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NRDE PF05742.7 ESA19385.1 - 1.5e-56 191.7 0.0 1.9e-56 191.4 0.0 1.0 1 0 0 1 1 1 1 NRDE protein PAH PF02671.16 ESA19391.1 - 0.11 12.1 2.0 6.6 6.4 0.0 3.8 4 1 0 4 4 4 0 Paired amphipathic helix repeat AAA_16 PF13191.1 ESA19392.1 - 2.5e-05 24.3 0.0 0.00013 21.9 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA19392.1 - 0.00018 21.6 0.0 0.00083 19.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA19392.1 - 0.024 14.3 0.0 0.054 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA19392.1 - 0.029 14.5 0.0 0.1 12.8 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESA19392.1 - 0.043 14.1 0.1 0.22 11.8 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 ESA19392.1 - 0.097 12.2 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2190 PF09956.4 ESA19393.1 - 0.099 12.4 0.9 4.1 7.2 0.0 2.8 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2190) DUF4134 PF13572.1 ESA19394.1 - 0.023 14.7 0.0 5.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) SH3BGR PF04908.10 ESA19394.1 - 0.03 14.2 0.1 12 5.9 0.0 2.9 2 1 1 3 3 3 0 SH3-binding, glutamic acid-rich protein Fer4_8 PF13183.1 ESA19394.1 - 0.032 14.2 0.9 6.6 6.8 0.0 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF2190 PF09956.4 ESA19394.1 - 0.05 13.3 0.1 5.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2190) DUF2542 PF10808.3 ESA19394.1 - 0.063 13.5 0.0 12 6.2 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2542) DUF2789 PF10982.3 ESA19394.1 - 0.088 12.8 1.4 8.5 6.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) DUF326 PF03860.11 ESA19394.1 - 0.21 11.4 6.3 1.9 8.4 0.5 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF326) Retrotrans_gag PF03732.12 ESA19398.1 - 1.7e-07 31.2 2.4 5e-07 29.6 1.6 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein Syntaxin_2 PF14523.1 ESA19398.1 - 1.3 9.1 9.2 0.43 10.6 0.5 3.1 3 0 0 3 3 3 0 Syntaxin-like protein Myb_DNA-bind_6 PF13921.1 ESA19399.1 - 0.00065 19.7 0.4 0.0009 19.2 0.3 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA19399.1 - 0.066 13.2 0.3 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain SAP30_Sin3_bdg PF13867.1 ESA19402.1 - 0.0036 17.1 0.4 0.78 9.6 0.0 2.6 1 1 1 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 Adeno_E1B_55K PF01696.12 ESA19402.1 - 0.049 12.0 0.4 0.062 11.7 0.3 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Scm3 PF10384.4 ESA19402.1 - 0.061 12.8 1.6 0.18 11.3 0.4 2.1 2 0 0 2 2 2 0 Centromere protein Scm3 Nucleoporin2 PF04096.9 ESA19402.1 - 0.1 12.4 3.1 2.1 8.1 0.2 2.0 1 1 1 2 2 2 0 Nucleoporin autopeptidase GlutR_dimer PF00745.15 ESA19402.1 - 0.1 12.5 0.5 0.13 12.2 0.4 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain EST1 PF10374.4 ESA19402.1 - 0.11 12.4 1.1 0.25 11.3 0.7 1.7 1 1 0 1 1 1 0 Telomerase activating protein Est1 zf-C3HC4_3 PF13920.1 ESA19403.1 - 4.2e-14 51.9 15.6 6.1e-14 51.4 10.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA19403.1 - 1.8e-05 24.6 19.7 3.3e-05 23.8 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA19403.1 - 0.0034 17.1 16.6 0.0061 16.3 11.5 1.5 1 0 0 1 1 1 1 Ring finger domain DUF1667 PF07892.6 ESA19403.1 - 0.096 12.3 0.6 0.24 11.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1667) zf-RING_5 PF14634.1 ESA19403.1 - 0.21 11.3 18.8 0.4 10.4 13.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF4106 PF13388.1 ESA19403.1 - 0.64 8.9 4.0 0.68 8.8 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) zf-C3HC4_4 PF15227.1 ESA19403.1 - 1.1 9.1 15.4 6.1 6.8 10.9 2.0 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF155 PF02582.9 ESA19404.1 - 7e-60 201.9 0.4 1.1e-59 201.3 0.3 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Pex14_N PF04695.8 ESA19405.1 - 1.6e-09 37.9 0.0 1.6e-09 37.9 0.0 2.7 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region IncA PF04156.9 ESA19405.1 - 0.00079 19.0 7.2 0.0013 18.3 5.0 1.3 1 0 0 1 1 1 1 IncA protein HlyD_2 PF12700.2 ESA19405.1 - 0.0099 15.0 2.1 0.013 14.6 1.5 1.3 1 0 0 1 1 1 1 HlyD family secretion protein Phage_GPO PF05929.6 ESA19405.1 - 0.017 14.3 5.5 0.028 13.6 3.8 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.7 ESA19405.1 - 0.02 14.6 10.3 0.053 13.3 6.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Hemerythrin PF01814.18 ESA19405.1 - 0.024 14.7 0.7 0.53 10.4 0.1 2.0 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain TM_helix PF05552.7 ESA19405.1 - 0.13 11.9 0.4 0.34 10.6 0.1 1.8 2 0 0 2 2 2 0 Conserved TM helix DUF4238 PF14022.1 ESA19405.1 - 0.13 11.5 3.3 0.18 11.0 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) Atg14 PF10186.4 ESA19405.1 - 0.19 10.6 4.8 0.28 10.0 3.3 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3584 PF12128.3 ESA19405.1 - 0.2 8.9 11.1 0.26 8.5 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 ESA19405.1 - 0.27 10.3 3.2 0.38 9.8 2.2 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 ESA19405.1 - 0.28 11.4 11.3 0.53 10.5 1.7 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein CR6_interact PF10147.4 ESA19405.1 - 0.35 10.1 7.1 0.54 9.5 4.9 1.3 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 USP8_interact PF08941.5 ESA19405.1 - 0.8 9.0 4.7 1.6 8.0 3.3 1.5 1 1 0 1 1 1 0 USP8 interacting Fib_alpha PF08702.5 ESA19405.1 - 2 8.5 12.8 1.7 8.7 7.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.6 ESA19405.1 - 2.1 6.9 15.8 1.7 7.2 9.4 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein APG6 PF04111.7 ESA19405.1 - 2.6 6.9 11.4 3.7 6.5 7.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESA19405.1 - 3.2 5.4 6.3 4.3 5.0 4.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF342 PF03961.8 ESA19405.1 - 4.9 5.4 11.6 8.6 4.6 8.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Mito_carr PF00153.22 ESA19406.1 - 4e-68 225.1 5.4 3.6e-24 84.2 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 ESA19406.1 - 1.7e-16 60.0 3.4 3.1e-08 33.6 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 ESA19406.1 - 1.1e-15 55.6 7.8 1.9e-05 23.6 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESA19406.1 - 1.6e-15 55.4 3.9 0.0057 16.4 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 ESA19406.1 - 3.5e-09 36.1 0.4 0.0011 18.5 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.1 ESA19406.1 - 4e-08 32.7 5.4 0.00012 21.6 0.1 4.5 2 2 3 5 5 5 2 EF hand EF-hand_5 PF13202.1 ESA19406.1 - 2.4e-07 29.8 7.0 0.031 13.6 0.3 4.1 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 ESA19406.1 - 3.5e-07 30.2 1.6 0.024 14.6 0.2 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Arg_repressor PF01316.16 ESA19406.1 - 0.0013 18.2 0.1 0.0027 17.2 0.1 1.5 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain EF-hand_4 PF12763.2 ESA19406.1 - 0.0075 15.9 2.6 2.9 7.6 0.3 2.9 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Longin PF13774.1 ESA19407.1 - 3.8e-30 103.2 1.1 3.8e-30 103.2 0.8 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 ESA19407.1 - 4.8e-18 64.5 0.1 9.5e-18 63.5 0.1 1.5 1 0 0 1 1 1 1 Synaptobrevin Imm42 PF15601.1 ESA19407.1 - 0.038 13.4 0.6 0.15 11.4 0.2 2.0 2 0 0 2 2 2 0 Immunity protein 42 ICMT PF04140.9 ESA19408.1 - 2.5e-28 98.1 0.4 4.5e-28 97.2 0.3 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESA19408.1 - 6.1e-12 45.5 0.9 1e-11 44.8 0.6 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.7 ESA19408.1 - 6.2e-05 22.4 0.3 7e-05 22.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.6 ESA19408.1 - 0.033 13.5 0.5 0.057 12.7 0.3 1.4 1 0 0 1 1 1 0 NnrU protein DUF262 PF03235.9 ESA19409.1 - 1.6e-11 44.6 0.1 1.9e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF262 Methyltransf_PK PF05891.7 ESA19409.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Ribosomal_L7Ae PF01248.21 ESA19411.1 - 1.4e-25 88.6 2.1 1.8e-25 88.2 1.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SpoU_sub_bind PF08032.7 ESA19411.1 - 0.11 12.6 0.1 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Cyclin_N PF00134.18 ESA19412.1 - 3.6e-14 52.4 1.3 1.8e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESA19412.1 - 0.0026 17.6 0.0 0.0077 16.1 0.0 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain TFIIB PF00382.14 ESA19412.1 - 0.057 13.2 0.0 7.8 6.3 0.0 2.7 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Clathrin_lg_ch PF01086.12 ESA19413.1 - 4.8e-50 170.5 7.5 6.5e-50 170.1 5.2 1.1 1 0 0 1 1 1 1 Clathrin light chain VWA_2 PF13519.1 ESA19414.1 - 1.4e-16 61.0 0.2 3.2e-16 59.9 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.15 ESA19414.1 - 2.7e-10 38.8 15.5 0.00081 18.7 0.3 4.1 4 0 0 4 4 4 3 Ubiquitin interaction motif Ssl1 PF04056.9 ESA19414.1 - 3.8e-09 36.4 0.1 8.3e-09 35.3 0.0 1.5 2 0 0 2 2 2 1 Ssl1-like VWA PF00092.23 ESA19414.1 - 3.5e-07 30.1 0.5 1.1e-06 28.4 0.3 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain Use1 PF09753.4 ESA19414.1 - 0.23 10.8 6.3 0.47 9.8 2.2 2.2 2 0 0 2 2 2 0 Membrane fusion protein Use1 MRI PF15325.1 ESA19414.1 - 7.8 7.5 11.4 0.81 10.6 4.3 1.9 2 0 0 2 2 2 0 Modulator of retrovirus infection GST_N PF02798.15 ESA19415.1 - 8.8e-13 48.2 0.0 9.1e-13 48.1 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 ESA19415.1 - 2.8e-12 46.6 0.0 3e-12 46.5 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA19415.1 - 3.7e-11 42.8 0.0 4e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GDA1_CD39 PF01150.12 ESA19416.1 - 2.4e-99 332.7 0.0 2.7e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family ESSS PF10183.4 ESA19417.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF2611 PF11022.3 ESA19418.1 - 1.8e-23 82.3 0.1 2e-23 82.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) TPR_11 PF13414.1 ESA19419.1 - 3e-12 45.9 5.1 1.8e-09 37.1 0.9 2.2 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESA19419.1 - 5e-11 41.6 1.9 0.0053 16.5 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA19419.1 - 1.1e-07 32.3 0.4 1.3e-05 25.7 0.1 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA19419.1 - 2.2e-06 27.0 6.8 0.23 11.1 0.2 4.4 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA19419.1 - 2.3e-05 24.6 1.1 0.72 10.6 0.0 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA19419.1 - 4.5e-05 23.2 4.5 0.00034 20.4 0.4 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 ESA19419.1 - 8e-05 22.5 0.7 0.87 9.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA19419.1 - 0.00018 21.0 6.2 0.0087 15.7 0.1 4.0 3 1 1 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.3 ESA19419.1 - 0.00036 19.4 1.5 0.0047 15.7 0.0 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.1 ESA19419.1 - 0.00067 19.9 5.4 0.035 14.5 0.1 4.0 3 2 1 4 4 4 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA19419.1 - 0.0052 16.8 4.3 1 9.5 0.3 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 ESA19419.1 - 0.0055 17.0 4.8 0.51 10.7 0.2 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA19419.1 - 0.061 13.1 1.8 2.1 8.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CPDase PF07823.6 ESA19419.1 - 0.098 12.1 0.8 0.11 11.9 0.1 1.5 2 0 0 2 2 2 0 Cyclic phosphodiesterase-like protein TPR_21 PF09976.4 ESA19419.1 - 0.11 12.3 3.6 0.25 11.2 2.5 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat ATP-synt_DE PF00401.15 ESA19419.1 - 0.15 11.9 1.5 0.29 11.0 1.1 1.5 1 0 0 1 1 1 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF1771 PF08590.5 ESA19419.1 - 0.16 11.9 0.8 0.59 10.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) LRR_6 PF13516.1 ESA19420.1 - 1.5e-08 33.8 22.9 0.16 12.1 0.1 9.3 10 0 0 10 10 10 3 Leucine Rich repeat LRR_4 PF12799.2 ESA19420.1 - 2.3e-08 33.4 15.6 0.011 15.3 0.8 6.1 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.2 ESA19420.1 - 2.4e-08 33.5 0.2 6.3e-08 32.2 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19420.1 - 5.5e-07 29.0 0.3 5.5e-07 29.0 0.2 2.7 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.1 ESA19420.1 - 0.00076 19.1 23.3 0.36 10.6 3.3 5.8 4 2 3 7 7 7 4 Leucine rich repeat LRR_7 PF13504.1 ESA19420.1 - 0.0035 17.2 12.1 3.1 8.4 0.0 7.4 7 1 0 7 7 7 2 Leucine rich repeat Ste50p-SAM PF09235.5 ESA19420.1 - 1 9.4 0.0 1 9.4 0.0 5.2 5 2 1 6 6 6 0 Ste50p, sterile alpha motif LRR_1 PF00560.28 ESA19420.1 - 1.1 9.5 26.6 8.1 6.9 0.2 8.7 7 5 1 8 8 8 0 Leucine Rich Repeat ADH_zinc_N_2 PF13602.1 ESA19421.1 - 2.1e-10 41.5 0.0 5.3e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 ESA19421.1 - 4.4e-09 35.9 0.0 7.5e-08 31.9 0.0 2.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 ESA19421.1 - 3e-06 26.9 0.0 1.1e-05 25.1 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Rxt3 PF08642.5 ESA19422.1 - 1.5e-19 70.3 1.7 3.5e-10 40.1 0.3 2.6 1 1 1 2 2 2 2 Histone deacetylation protein Rxt3 LCCL PF03815.14 ESA19422.1 - 0.00074 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 LCCL domain NOA36 PF06524.7 ESA19422.1 - 0.12 11.5 7.3 0.19 10.9 5.0 1.2 1 0 0 1 1 1 0 NOA36 protein Prothymosin PF03247.9 ESA19422.1 - 1.5 8.9 19.0 3.6 7.8 13.2 1.6 1 0 0 1 1 1 0 Prothymosin/parathymosin family F-actin_cap_A PF01267.12 ESA19423.1 - 3e-97 324.9 1.3 3.4e-97 324.7 0.9 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit F_actin_cap_B PF01115.12 ESA19423.1 - 0.0046 16.1 0.7 0.0074 15.5 0.5 1.3 1 1 0 1 1 1 1 F-actin capping protein, beta subunit DUF1752 PF08550.5 ESA19424.1 - 2.2e-11 43.0 0.6 5.1e-11 41.9 0.4 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DNA_methylase PF00145.12 ESA19427.1 - 3.3e-26 92.2 0.2 3.9e-26 91.9 0.1 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BTB PF00651.26 ESA19428.1 - 4e-16 58.9 0.3 7.2e-16 58.1 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19428.1 - 3.1e-10 40.1 0.8 6.8e-10 39.0 0.1 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19428.1 - 3.1e-06 26.9 2.6 0.011 15.6 0.1 3.6 2 1 2 4 4 4 2 BTB And C-terminal Kelch Urm1 PF09138.6 ESA19428.1 - 0.11 12.5 0.3 0.46 10.6 0.2 2.2 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) BTB PF00651.26 ESA19429.1 - 3.6e-18 65.5 0.2 6.9e-18 64.6 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA19429.1 - 6.1e-09 35.9 2.1 8.4e-09 35.5 0.3 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA19429.1 - 0.033 14.0 0.3 0.033 14.0 0.2 3.7 4 1 1 5 5 5 0 BTB And C-terminal Kelch RepA_N PF06970.6 ESA19429.1 - 0.078 12.7 1.7 0.99 9.2 0.1 3.3 3 0 0 3 3 3 0 Replication initiator protein A (RepA) N-terminus DUF4496 PF14908.1 ESA19431.1 - 0.022 14.6 0.0 0.033 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4496) RNA_pol_A_CTD PF03118.10 ESA19432.1 - 0.043 13.2 1.0 0.074 12.4 0.1 1.8 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain Dict-STAT-coil PF09267.5 ESA19432.1 - 0.15 12.3 2.4 0.87 9.8 0.1 2.6 3 0 0 3 3 3 0 Dictyostelium STAT, coiled coil ZZ PF00569.12 ESA19433.1 - 0.00011 21.6 2.9 0.00011 21.6 2.0 2.8 3 1 0 3 3 3 1 Zinc finger, ZZ type Prok-RING_2 PF14445.1 ESA19433.1 - 9 6.3 10.9 4.1 7.4 1.4 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 2 p450 PF00067.17 ESA19434.1 - 2.8e-55 187.6 0.0 3.5e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NYN PF01936.13 ESA19435.1 - 2.1e-11 44.2 0.0 8.1e-11 42.4 0.0 1.9 2 0 0 2 2 2 1 NYN domain Kelch_3 PF13415.1 ESA19436.1 - 6.9e-17 61.1 2.5 0.0025 17.9 0.0 5.3 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA19436.1 - 4.7e-16 58.0 10.6 0.00015 21.2 0.3 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.1 ESA19436.1 - 4.2e-15 55.2 9.3 0.00025 20.7 0.0 5.5 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA19436.1 - 4.2e-15 55.1 12.1 0.00024 21.1 0.0 4.8 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.10 ESA19436.1 - 5.6e-15 54.4 1.3 4.6e-06 26.1 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.1 ESA19436.1 - 8.3e-15 54.3 13.2 1.6e-05 24.7 0.1 5.0 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ESA19437.1 - 4.7e-27 93.5 12.3 7.9e-05 22.3 0.0 6.7 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA19437.1 - 1.5e-21 75.2 3.2 1e-06 28.2 0.0 6.3 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 ESA19437.1 - 5.4e-21 73.8 16.0 0.00028 20.9 0.1 6.5 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA19437.1 - 3.9e-19 68.2 9.8 0.0011 19.1 0.0 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA19437.1 - 2.2e-17 62.2 13.4 0.0003 20.2 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.1 ESA19437.1 - 2.7e-15 55.9 18.9 5.9e-05 22.9 0.2 5.9 6 0 0 6 6 6 4 Kelch motif Rax2 PF12768.2 ESA19437.1 - 1.8e-05 24.1 0.9 0.00057 19.1 0.2 2.8 3 0 0 3 3 3 1 Cortical protein marker for cell polarity SKG6 PF08693.5 ESA19437.1 - 0.00024 20.3 2.8 0.00046 19.4 1.9 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rifin_STEVOR PF02009.11 ESA19437.1 - 0.00037 20.2 0.0 0.00057 19.6 0.0 1.2 1 0 0 1 1 1 1 Rifin/stevor family Adeno_E3_CR2 PF02439.10 ESA19437.1 - 0.0016 17.9 0.6 0.0034 16.8 0.4 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Mid2 PF04478.7 ESA19437.1 - 0.032 13.6 0.1 0.064 12.6 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF872 PF05915.7 ESA19437.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Tetraspannin PF00335.15 ESA19437.1 - 0.07 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Tetraspanin family Kelch_4 PF13418.1 ESA19438.1 - 3.6e-32 109.8 13.7 4.2e-07 29.6 0.3 7.2 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA19438.1 - 5.6e-22 77.0 12.4 5e-05 22.7 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 ESA19438.1 - 6.9e-22 76.9 13.3 2.9e-06 27.0 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA19438.1 - 7.9e-22 76.4 14.8 4.1e-06 26.7 0.3 6.5 4 1 2 6 6 6 5 Kelch motif Kelch_2 PF07646.10 ESA19438.1 - 5.1e-21 73.5 5.6 2.7e-05 23.7 0.1 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_3 PF13415.1 ESA19438.1 - 1.2e-20 73.0 13.1 1.2e-05 25.3 0.3 7.9 8 0 0 8 8 8 5 Galactose oxidase, central domain MGC-24 PF05283.6 ESA19438.1 - 0.084 12.6 5.2 0.13 12.0 3.6 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) FixQ PF05545.6 ESA19438.1 - 0.12 12.0 0.0 0.38 10.4 0.0 1.8 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Pkinase_Tyr PF07714.12 ESA19440.1 - 1e-30 106.6 0.0 4.2e-30 104.6 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19440.1 - 2.9e-29 102.0 0.0 5.6e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA19440.1 - 0.0051 15.8 0.0 0.0081 15.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kelch_4 PF13418.1 ESA19441.1 - 1.3e-26 92.1 7.6 7.7e-07 28.7 0.0 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA19441.1 - 4.3e-22 77.3 14.4 4.5e-08 32.9 0.0 5.8 4 1 2 6 6 6 4 Kelch motif Kelch_1 PF01344.20 ESA19441.1 - 5.8e-22 76.9 14.5 1.5e-07 30.8 0.0 5.9 5 1 0 5 5 5 4 Kelch motif Kelch_5 PF13854.1 ESA19441.1 - 2.2e-21 75.3 16.3 3.3e-06 26.9 0.2 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 ESA19441.1 - 2.5e-18 65.0 5.3 0.00073 19.2 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA19441.1 - 1.3e-17 63.4 0.2 7.7e-05 22.7 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain PMP1_2 PF08114.6 ESA19441.1 - 0.0071 15.8 0.5 0.018 14.5 0.3 1.6 1 0 0 1 1 1 1 ATPase proteolipid family Shisa PF13908.1 ESA19441.1 - 0.11 12.6 5.4 0.28 11.3 3.5 1.9 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator CcmD PF04995.9 ESA19441.1 - 0.45 10.2 1.4 0.87 9.3 1.0 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Kelch_6 PF13964.1 ESA19442.1 - 1.8e-28 97.4 7.0 1.9e-05 24.6 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.20 ESA19442.1 - 5.8e-23 80.1 8.6 4.9e-05 22.7 0.0 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.1 ESA19442.1 - 1.4e-21 76.0 9.2 0.00023 20.8 0.0 6.8 5 2 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA19442.1 - 5.8e-21 73.3 1.9 2.2e-05 24.0 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.1 ESA19442.1 - 2.1e-20 72.3 4.9 1.7e-05 24.8 0.1 6.4 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA19442.1 - 1.2e-19 69.8 12.0 6e-05 22.9 0.2 5.7 5 1 0 5 5 5 4 Kelch motif Sec6 PF06046.8 ESA19444.1 - 3.8e-116 388.4 12.1 5.3e-116 387.9 8.4 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 SBDS_C PF09377.5 ESA19445.1 - 1.9e-42 143.9 4.8 1.9e-42 143.9 3.3 1.6 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.13 ESA19445.1 - 1.7e-34 117.4 1.9 3.4e-34 116.4 1.3 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein CAMSAP_CKK PF08683.6 ESA19445.1 - 0.011 15.4 0.2 0.024 14.3 0.1 1.7 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated DUF3095 PF11294.3 ESA19445.1 - 0.012 14.6 1.5 0.018 14.0 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) DUF1092 PF06485.6 ESA19445.1 - 0.012 14.5 1.0 0.62 8.9 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1092) CPSase_L_D3 PF02787.14 ESA19445.1 - 0.028 14.2 1.4 0.059 13.1 0.1 2.1 3 0 0 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain UCH_1 PF13423.1 ESA19445.1 - 0.048 13.0 2.6 0.061 12.7 1.8 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase CDC37_C PF08564.5 ESA19445.1 - 0.056 13.2 0.4 0.19 11.5 0.2 2.0 1 1 0 1 1 1 0 Cdc37 C terminal domain HTH_22 PF13309.1 ESA19445.1 - 0.31 10.8 2.2 0.61 9.8 0.2 2.2 2 0 0 2 2 2 0 HTH domain PNPase PF03726.9 ESA19445.1 - 2.6 8.3 7.5 0.94 9.7 0.4 2.9 2 1 2 4 4 4 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF262 PF03235.9 ESA19446.1 - 1e-17 64.8 3.9 1.6e-17 64.2 2.6 1.7 1 1 0 1 1 1 1 Protein of unknown function DUF262 Thioredoxin_4 PF13462.1 ESA19448.1 - 3.5e-11 43.3 0.0 4.6e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin SP_C-Propep PF08999.5 ESA19449.1 - 0.079 12.4 0.1 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide APH PF01636.18 ESA19450.1 - 1.4e-10 41.3 0.0 7.5e-08 32.3 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 ESA19450.1 - 0.0013 18.2 0.1 0.003 17.1 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase EcKinase PF02958.15 ESA19450.1 - 0.0017 17.5 0.0 0.0035 16.5 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase CENP-K PF11802.3 ESA19451.1 - 0.032 13.4 1.1 0.035 13.3 0.7 1.0 1 0 0 1 1 1 0 Centromere-associated protein K DUF972 PF06156.8 ESA19451.1 - 0.036 14.4 1.1 0.043 14.1 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 ESA19451.1 - 0.39 11.4 3.7 0.47 11.2 2.0 1.4 1 1 1 2 2 2 0 Occludin homology domain Lipase_GDSL PF00657.17 ESA19452.1 - 4.2e-25 88.9 0.0 5.4e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 ESA19452.1 - 8.7e-23 81.3 0.0 1.1e-22 81.0 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_3 PF14606.1 ESA19452.1 - 0.00017 21.4 0.1 0.00042 20.1 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Peripla_BP_4 PF13407.1 ESA19452.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein domain Dimer_Tnp_hAT PF05699.9 ESA19452.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region FA_FANCE PF11510.3 ESA19453.1 - 5.4e-06 25.7 1.2 5.6e-05 22.4 0.8 2.0 1 1 0 1 1 1 1 Fanconi Anaemia group E protein FANCE 7TMR-HDED PF07697.6 ESA19453.1 - 0.0087 15.8 0.0 0.017 14.8 0.0 1.5 1 1 0 1 1 1 1 7TM-HD extracellular Acetyltransf_1 PF00583.19 ESA19454.1 - 4.4e-14 52.2 0.0 6.6e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 ESA19454.1 - 4.8e-06 26.6 0.0 6.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 ESA19454.1 - 9e-05 22.5 0.1 0.00012 22.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA19454.1 - 0.00028 20.5 0.0 0.00048 19.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 ESA19454.1 - 0.00034 20.4 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain OTCace PF00185.19 ESA19454.1 - 0.068 13.0 0.4 0.11 12.3 0.3 1.3 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain PH_4 PF15404.1 ESA19456.1 - 0.012 15.1 2.5 0.016 14.7 1.7 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain Baculo_PEP_C PF04513.7 ESA19456.1 - 0.1 12.4 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Viral_DNA_Zn_bi PF03728.8 ESA19456.1 - 0.35 10.9 2.4 1.6 8.8 0.2 2.0 1 1 1 2 2 2 0 Viral DNA-binding protein, zinc binding domain DUF1283 PF06932.6 ESA19456.1 - 2.5 8.2 6.9 3.6 7.6 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1283) Pentapeptide_4 PF13599.1 ESA19457.1 - 0.039 13.7 1.1 5.4 6.9 0.0 2.8 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) Glyco_hydro_15 PF00723.16 ESA19461.1 - 4.2e-59 200.2 0.0 3.1e-57 194.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 DUF2591 PF10765.4 ESA19462.1 - 7.5 6.8 10.0 0.33 11.2 0.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2591) EmrE PF13536.1 ESA19463.1 - 0.12 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Multidrug resistance efflux transporter Nol1_Nop2_Fmu PF01189.12 ESA19464.1 - 3.5e-25 88.9 0.0 6.4e-25 88.0 0.0 1.5 1 1 0 1 1 1 1 NOL1/NOP2/sun family FtsJ PF01728.14 ESA19464.1 - 0.001 19.1 0.0 0.0027 17.7 0.0 1.9 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 ESA19464.1 - 0.0013 18.3 0.2 0.0035 16.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Piwi PF02171.12 ESA19466.1 - 5.4e-21 74.8 0.1 5.4e-21 74.8 0.1 1.8 2 0 0 2 2 2 1 Piwi domain DUF1785 PF08699.5 ESA19466.1 - 3.6e-08 32.6 0.1 8.4e-08 31.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) PAZ PF02170.17 ESA19466.1 - 0.0049 16.1 0.3 0.0049 16.1 0.2 2.4 2 0 0 2 2 2 1 PAZ domain Myb_DNA-binding PF00249.26 ESA19467.1 - 0.024 14.7 1.5 0.39 10.8 0.1 2.4 2 1 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA19467.1 - 0.077 13.6 3.8 0.044 14.4 1.4 1.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Phage_P2_GpU PF06995.6 ESA19467.1 - 0.11 11.9 0.1 0.27 10.6 0.1 1.6 2 0 0 2 2 2 0 Phage P2 GpU Myb_DNA-bind_6 PF13921.1 ESA19467.1 - 0.34 11.0 6.1 0.55 10.3 0.9 2.7 1 1 1 2 2 2 0 Myb-like DNA-binding domain Mem_trans PF03547.13 ESA19468.1 - 0.61 8.3 8.1 1.2 7.3 4.0 2.3 1 1 0 1 1 1 0 Membrane transport protein DUF3725 PF12523.3 ESA19469.1 - 0.053 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) DUF3596 PF12167.3 ESA19469.1 - 0.14 11.7 0.1 0.26 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3596) Pkinase_Tyr PF07714.12 ESA19471.1 - 5.7e-27 94.4 0.0 2.2e-25 89.1 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19471.1 - 2.2e-20 72.9 3.7 8.6e-20 70.9 2.6 2.0 1 1 0 1 1 1 1 Protein kinase domain Luciferase_cat PF10285.4 ESA19471.1 - 0.0069 15.5 0.1 1.3 8.1 0.0 2.6 3 0 0 3 3 3 2 Luciferase catalytic domain YejG PF13989.1 ESA19471.1 - 0.016 15.2 0.6 5.5 7.0 0.0 3.5 3 0 0 3 3 3 0 YejG-like protein DUF4134 PF13572.1 ESA19471.1 - 0.017 15.2 0.1 19 5.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4134) ACDC PF14733.1 ESA19471.1 - 0.048 13.7 3.1 1.3 9.2 0.3 3.1 2 0 0 2 2 2 0 AP2-coincident C-terminal Homez PF11569.3 ESA19471.1 - 0.069 12.2 0.0 15 4.7 0.0 2.6 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez ASC PF00858.19 ESA19471.1 - 5 5.6 15.7 1.6 7.2 0.8 3.7 4 0 0 4 4 4 0 Amiloride-sensitive sodium channel DUF4441 PF14536.1 ESA19471.1 - 7.3 6.6 26.6 0.59 10.1 0.4 5.1 5 2 0 5 5 5 0 Domain of unknown function (DUF4441) DUF2408 PF10303.4 ESA19472.1 - 0.0015 18.6 3.5 0.86 9.7 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2408) TraT PF05818.7 ESA19472.1 - 0.0049 16.3 0.3 1.9 7.8 0.0 2.2 2 0 0 2 2 2 2 Enterobacterial TraT complement resistance protein DUF2789 PF10982.3 ESA19472.1 - 0.027 14.4 4.8 1.4 8.9 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) zf-Tim10_DDP PF02953.10 ESA19472.1 - 0.12 11.6 8.0 0.85 8.9 0.8 2.5 2 0 0 2 2 2 0 Tim10/DDP family zinc finger UBA PF00627.26 ESA19472.1 - 0.26 11.2 2.1 37 4.3 0.0 3.2 3 0 0 3 3 3 0 UBA/TS-N domain XPA_N PF01286.13 ESA19472.1 - 0.49 10.1 6.0 5 6.8 0.4 2.5 2 0 0 2 2 2 0 XPA protein N-terminal zf-C4_ClpX PF06689.8 ESA19472.1 - 1.1 8.7 13.2 3.5 7.2 1.9 2.4 2 0 0 2 2 2 0 ClpX C4-type zinc finger ACDC PF14733.1 ESA19472.1 - 2.3 8.3 6.6 19 5.4 0.1 2.8 2 1 0 2 2 2 0 AP2-coincident C-terminal DUF226 PF02890.9 ESA19472.1 - 4.6 7.0 15.4 1.9 8.2 0.8 3.3 3 0 0 3 3 3 0 Borrelia family of unknown function DUF226 Tropomyosin_1 PF12718.2 ESA19475.1 - 0.003 17.3 12.8 0.003 17.3 8.8 4.0 2 1 2 4 4 4 2 Tropomyosin like FliT PF05400.8 ESA19475.1 - 0.026 14.9 8.7 0.52 10.7 0.0 4.6 4 1 0 4 4 4 0 Flagellar protein FliT Rootletin PF15035.1 ESA19475.1 - 0.88 9.5 27.3 0.15 12.0 8.0 3.9 3 1 1 4 4 4 0 Ciliary rootlet component, centrosome cohesion DUF3166 PF11365.3 ESA19475.1 - 1.1 9.7 9.7 0.4 11.1 2.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3166) bZIP_1 PF00170.16 ESA19475.1 - 2 8.4 23.8 0.25 11.3 1.3 5.1 3 1 1 4 4 4 0 bZIP transcription factor CENP-F_leu_zip PF10473.4 ESA19475.1 - 3.2 7.6 25.8 0.083 12.7 8.5 4.3 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 S1 PF00575.18 ESA19480.1 - 6.9e-50 167.0 35.4 1.1e-14 54.2 1.3 11.8 11 1 0 11 11 11 9 S1 RNA binding domain TPR_19 PF14559.1 ESA19480.1 - 5e-06 26.7 0.0 0.048 13.9 0.0 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat Suf PF05843.9 ESA19480.1 - 1.6e-05 24.7 1.6 1.6e-05 24.7 1.1 5.0 2 1 2 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.1 ESA19480.1 - 0.0021 18.5 0.0 9.7 7.1 0.0 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA19480.1 - 0.0054 16.3 0.2 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.1 ESA19480.1 - 0.01 16.4 0.0 0.13 12.9 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SH3_2 PF07653.12 ESA19480.1 - 0.013 14.9 0.5 0.45 10.0 0.0 3.4 3 0 0 3 3 3 0 Variant SH3 domain TPR_12 PF13424.1 ESA19480.1 - 0.026 14.4 1.1 4.8 7.1 0.2 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat Neurochondrin PF05536.6 ESA19481.1 - 8.6e-82 275.1 20.0 1.1e-81 274.7 13.9 1.2 1 0 0 1 1 1 1 Neurochondrin U3snoRNP10 PF12397.3 ESA19481.1 - 3.4 7.6 9.9 2.9 7.8 0.7 4.5 4 2 1 5 5 5 0 U3 small nucleolar RNA-associated protein 10 Ras PF00071.17 ESA19482.1 - 2.5e-13 49.7 0.1 7.5e-06 25.4 0.0 2.7 2 0 0 2 2 2 2 Ras family Miro PF08477.8 ESA19482.1 - 0.00011 22.6 0.0 0.02 15.3 0.0 2.7 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA19482.1 - 0.01 15.0 2.1 0.12 11.6 0.0 2.6 3 0 0 3 3 3 0 ADP-ribosylation factor family IIGP PF05049.8 ESA19482.1 - 0.018 13.8 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.18 ESA19482.1 - 0.02 14.8 0.0 0.054 13.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Nsp1_C PF05064.8 ESA19483.1 - 0.0014 18.2 4.0 0.0056 16.3 2.7 2.0 1 0 0 1 1 1 1 Nsp1-like C-terminal region DUF724 PF05266.9 ESA19483.1 - 0.014 15.0 3.8 0.016 14.8 1.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Mitofilin PF09731.4 ESA19483.1 - 0.026 13.1 17.1 0.053 12.1 11.9 1.5 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Tropomyosin PF00261.15 ESA19483.1 - 0.062 12.3 8.4 0.011 14.9 2.9 1.8 2 0 0 2 2 2 0 Tropomyosin IncA PF04156.9 ESA19483.1 - 0.1 12.2 2.2 0.19 11.2 1.5 1.4 1 0 0 1 1 1 0 IncA protein TLD PF07534.11 ESA19484.1 - 3.9e-10 39.8 1.5 6.3e-10 39.1 1.1 1.3 1 1 0 1 1 1 1 TLD zf-LITAF-like PF10601.4 ESA19485.1 - 4.3e-20 71.3 9.5 5.9e-20 70.9 6.6 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain RecR PF02132.10 ESA19485.1 - 0.12 11.7 4.6 0.17 11.3 0.3 2.2 2 0 0 2 2 2 0 RecR protein DnaJ PF00226.26 ESA19486.1 - 1.3e-07 31.2 0.1 2.1e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 ESA19486.1 - 8.1e-07 28.8 0.1 8.3e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Pam16 Ion_trans PF00520.26 ESA19487.1 - 0.00052 19.3 12.7 0.00083 18.6 8.8 1.3 1 0 0 1 1 1 1 Ion transport protein DUF4191 PF13829.1 ESA19487.1 - 2.7 7.0 6.0 0.23 10.5 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Ion_trans PF00520.26 ESA19488.1 - 0.00037 19.8 16.1 0.00052 19.3 11.2 1.2 1 0 0 1 1 1 1 Ion transport protein zf-DHHC PF01529.15 ESA19488.1 - 1.1 8.6 15.0 2.8 7.3 0.2 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase PKD_channel PF08016.7 ESA19488.1 - 1.6 7.0 14.3 0.35 9.2 4.2 2.1 2 0 0 2 2 2 0 Polycystin cation channel Abhydrolase_5 PF12695.2 ESA19489.1 - 0.00087 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2522 PF10747.4 ESA19489.1 - 0.048 13.6 0.0 9.3 6.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2522) Esterase_phd PF10503.4 ESA19489.1 - 0.085 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase UBA_3 PF09288.5 ESA19490.1 - 0.74 9.4 3.8 0.26 10.8 0.6 1.7 1 1 1 2 2 2 0 Fungal ubiquitin-associated domain DUF912 PF06024.7 ESA19490.1 - 1.9 8.6 5.0 2.1 8.4 3.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DDE_Tnp_ISAZ013 PF07592.6 ESA19492.1 - 0.0058 15.4 0.0 0.25 10.0 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain ubiquitin PF00240.18 ESA19493.1 - 0.0091 15.3 0.2 0.086 12.2 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin family Peptidase_M48 PF01435.13 ESA19493.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M48 Pkinase_Tyr PF07714.12 ESA19494.1 - 0.00043 19.4 0.0 0.00056 19.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Vezatin PF12632.2 ESA19494.1 - 0.0097 15.0 0.2 0.012 14.7 0.1 1.1 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes SMI1_KNR4 PF09346.5 ESA19494.1 - 0.084 12.8 0.3 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 SMI1 / KNR4 family (SUKH-1) tRNA-synt_1 PF00133.17 ESA19498.1 - 4e-37 127.4 0.0 1.1e-25 89.7 0.0 3.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 ESA19498.1 - 3.1e-18 65.6 0.0 1.6e-09 36.9 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 ESA19498.1 - 1.7e-16 60.3 0.0 4.4e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 ESA19498.1 - 4.5e-06 25.9 0.0 1.1e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain F-box-like PF12937.2 ESA19501.1 - 0.0071 16.0 0.5 0.0071 16.0 0.4 2.1 2 0 0 2 2 2 1 F-box-like CPG4 PF15481.1 ESA19501.1 - 0.11 12.7 2.1 0.44 10.9 0.3 2.3 2 0 0 2 2 2 0 Chondroitin proteoglycan 4 VAR1 PF05316.7 ESA19502.1 - 0.0047 15.5 2.2 0.0053 15.4 1.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) WD40 PF00400.27 ESA19504.1 - 2.6e-69 226.8 10.0 5.9e-13 48.1 0.0 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 ESA19504.1 - 5.2e-06 25.0 0.2 0.085 11.1 0.0 2.8 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nbas_N PF15492.1 ESA19504.1 - 3.8e-05 22.9 0.5 0.15 11.1 0.0 4.2 1 1 5 6 6 6 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.3 ESA19504.1 - 6.2e-05 21.3 0.9 0.14 10.2 0.0 3.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.7 ESA19504.1 - 9.8e-05 21.9 0.9 0.99 9.1 0.0 4.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Gmad1 PF10647.4 ESA19504.1 - 0.00033 20.1 0.1 0.06 12.7 0.0 2.6 1 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain VID27 PF08553.5 ESA19504.1 - 0.0032 15.7 0.0 1.1 7.3 0.0 2.2 2 0 0 2 2 2 2 VID27 cytoplasmic protein DUF4402 PF14352.1 ESA19504.1 - 0.015 15.7 0.0 3.7 8.0 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4402) Proteasome_A_N PF10584.4 ESA19504.1 - 1.6 8.1 12.3 25 4.3 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Rad21_Rec8 PF04824.11 ESA19506.1 - 1.4e-09 37.0 0.0 2.2e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 ESA19506.1 - 0.00086 18.9 0.1 0.001 18.7 0.0 1.1 1 0 0 1 1 1 1 ScpA/B protein TFIID_90kDa PF04494.10 ESA19506.1 - 0.016 15.3 0.2 0.03 14.3 0.1 1.5 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit DUF1368 PF07112.6 ESA19507.1 - 0.1 11.1 0.3 0.11 11.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) Metallophos PF00149.23 ESA19508.1 - 8e-14 51.4 9.0 1.7e-12 47.1 6.2 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA19508.1 - 7.4e-06 25.8 0.0 1.4e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2098 PF09871.4 ESA19508.1 - 0.055 13.3 1.1 0.12 12.3 0.8 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Kelch_5 PF13854.1 ESA19509.1 - 1.4e-17 63.1 3.9 0.0029 17.5 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA19509.1 - 1e-16 60.5 7.2 0.023 14.8 0.0 7.4 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA19509.1 - 2.7e-15 55.8 11.5 0.0012 18.5 0.2 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA19509.1 - 2.2e-10 39.9 14.5 0.021 14.3 0.0 6.0 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA19509.1 - 5.9e-09 35.7 10.7 0.093 12.9 0.0 5.9 5 1 1 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA19509.1 - 2.9e-08 33.1 0.1 0.21 11.4 0.0 5.4 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.9 ESA19509.1 - 0.0096 14.6 0.1 21 3.6 0.0 4.2 2 1 2 5 5 5 0 Recombination activating protein 2 Abhydrolase_3 PF07859.8 ESA19510.1 - 0.0063 16.1 0.1 0.01 15.4 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA19510.1 - 0.034 12.8 0.0 0.045 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2424) UvrD_C_2 PF13538.1 ESA19512.1 - 0.055 13.6 0.0 0.13 12.4 0.0 1.7 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain DUF4218 PF13960.1 ESA19513.1 - 0.00028 20.3 0.1 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DUF211 PF02680.9 ESA19516.1 - 0.073 12.8 0.0 0.077 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 Pkinase_Tyr PF07714.12 ESA19517.1 - 5.4e-47 160.0 0.0 7.9e-47 159.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19517.1 - 2.1e-39 135.2 0.0 4.7e-39 134.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA19517.1 - 0.012 14.9 0.0 0.029 13.6 0.0 1.6 1 0 0 1 1 1 0 RIO1 family DUF2135 PF09906.4 ESA19517.1 - 0.099 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) Pkinase_Tyr PF07714.12 ESA19518.1 - 4.2e-35 121.0 0.0 7.1e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19518.1 - 3.4e-31 108.3 0.0 5.7e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA19518.1 - 9.1e-08 32.4 16.5 8.8e-05 23.0 1.9 4.2 4 0 0 4 4 4 3 Sel1 repeat Raptor_N PF14538.1 ESA19519.1 - 6.9e-68 227.3 0.0 1.7e-67 226.0 0.0 1.8 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.27 ESA19519.1 - 4.4e-17 61.2 2.6 0.00054 19.7 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat HEAT PF02985.17 ESA19519.1 - 2.2e-09 36.5 5.2 0.00064 19.5 0.0 5.7 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.1 ESA19519.1 - 7.1e-08 32.6 1.6 0.00017 21.8 0.7 3.3 1 1 1 2 2 2 2 HEAT repeats BBS2_Mid PF14783.1 ESA19519.1 - 2.5e-05 24.0 0.0 0.0046 16.7 0.0 2.8 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region HEAT_EZ PF13513.1 ESA19519.1 - 0.0042 17.5 3.6 0.085 13.3 0.1 4.0 2 1 2 4 4 4 2 HEAT-like repeat Peptidase_C14 PF00656.17 ESA19519.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Caspase domain Nucleoporin_N PF08801.6 ESA19519.1 - 0.02 13.6 0.1 0.049 12.3 0.1 1.6 1 0 0 1 1 1 0 Nup133 N terminal like DUF2435 PF10363.4 ESA19519.1 - 0.09 12.6 0.2 0.4 10.5 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2435) DUF2621 PF11084.3 ESA19519.1 - 0.11 12.1 0.0 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2621) PfkB PF00294.19 ESA19520.1 - 1e-61 208.6 0.0 1.3e-61 208.3 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 ESA19520.1 - 0.0055 15.9 0.0 0.0097 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase LIM PF00412.17 ESA19521.1 - 2.4e-35 120.3 34.1 3.4e-14 52.6 0.5 3.9 4 0 0 4 4 4 3 LIM domain zf-dskA_traR PF01258.12 ESA19521.1 - 0.16 11.7 0.2 0.16 11.7 0.2 4.6 5 0 0 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger Syntaxin_2 PF14523.1 ESA19522.1 - 0.036 14.0 0.8 0.036 14.0 0.6 2.4 1 1 1 2 2 2 0 Syntaxin-like protein Syntaxin-6_N PF09177.6 ESA19522.1 - 0.38 11.1 4.0 4.1 7.8 2.8 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Myb_DNA-bind_6 PF13921.1 ESA19522.1 - 0.43 10.7 2.7 0.94 9.6 1.9 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Macoilin PF09726.4 ESA19522.1 - 8.4 4.5 9.3 12 4.0 6.5 1.1 1 0 0 1 1 1 0 Transmembrane protein FliJ PF02050.11 ESA19522.1 - 9.5 6.2 15.0 6 6.9 2.2 2.8 1 1 1 3 3 3 0 Flagellar FliJ protein SH3BGR PF04908.10 ESA19523.1 - 0.0067 16.3 0.7 0.01 15.7 0.4 1.4 1 1 0 1 1 1 1 SH3-binding, glutamic acid-rich protein V-SNARE PF05008.10 ESA19523.1 - 0.027 14.6 1.2 0.043 13.9 0.8 1.4 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Phage_tail_2 PF06199.6 ESA19523.1 - 0.036 14.1 0.2 0.051 13.6 0.1 1.3 1 0 0 1 1 1 0 Phage major tail protein 2 V_ATPase_I PF01496.14 ESA19523.1 - 0.092 10.5 2.4 0.088 10.6 1.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FerB PF08150.7 ESA19523.1 - 0.13 12.3 0.1 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 FerB (NUC096) domain FliD_N PF02465.13 ESA19523.1 - 0.15 12.4 0.3 0.19 12.1 0.2 1.3 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus SPAN-X PF07458.7 ESA19523.1 - 0.31 11.2 3.6 0.46 10.7 2.4 1.4 1 1 0 1 1 1 0 Sperm protein associated with nucleus, mapped to X chromosome Pkinase_Tyr PF07714.12 ESA19524.1 - 2.5e-15 56.2 0.0 3.3e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19524.1 - 4.6e-10 39.0 0.0 6.3e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SRF-TF PF00319.13 ESA19525.1 - 8.7e-24 82.5 0.1 1.1e-23 82.2 0.1 1.1 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Pkinase PF00069.20 ESA19526.1 - 2.6e-36 125.1 0.3 6.4e-36 123.8 0.0 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19526.1 - 9.8e-36 123.1 0.0 1.6e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA19526.1 - 0.056 12.5 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PsbU PF06514.6 ESA19526.1 - 0.058 13.2 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pkinase_Tyr PF07714.12 ESA19527.1 - 7.2e-45 153.0 0.0 1.2e-44 152.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19527.1 - 1.4e-41 142.3 0.1 2.3e-41 141.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA19527.1 - 0.019 14.7 0.5 0.03 14.0 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA19527.1 - 0.04 13.1 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA19527.1 - 0.12 11.6 1.8 0.13 11.6 0.0 1.8 2 1 0 2 2 2 0 RIO1 family p450 PF00067.17 ESA19529.1 - 8.7e-36 123.4 0.1 1e-35 123.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA19530.1 - 1.5e-39 135.7 0.2 1.9e-39 135.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 HMG_box PF00505.14 ESA19531.1 - 4.7e-06 26.7 1.5 1e-05 25.7 1.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box Complex1_LYR_1 PF13232.1 ESA19531.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Complex1_LYR-like HMG_box_2 PF09011.5 ESA19531.1 - 0.1 12.9 1.1 0.2 12.0 0.7 1.4 1 0 0 1 1 1 0 HMG-box domain DUF2552 PF10827.3 ESA19534.1 - 0.004 17.0 0.3 0.0058 16.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2552) Proteasome PF00227.21 ESA19536.1 - 1.5e-50 171.1 0.0 1.7e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 ESA19536.1 - 0.055 12.7 1.0 0.098 12.0 0.1 1.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Mpv17_PMP22 PF04117.7 ESA19537.1 - 4.1e-25 87.1 0.2 6.9e-25 86.4 0.2 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF3608 PF12257.3 ESA19538.1 - 3.2e-74 249.3 0.3 5.7e-74 248.5 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 ESA19538.1 - 1.5e-23 82.2 0.4 4e-23 80.9 0.3 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) BTB PF00651.26 ESA19539.1 - 4.5e-16 58.8 0.0 8.8e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA19539.1 - 9.5e-06 25.3 1.3 0.00037 20.3 0.6 3.1 2 1 0 2 2 2 1 BTB And C-terminal Kelch F-box-like PF12937.2 ESA19540.1 - 3.2e-08 33.1 0.1 6.4e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19540.1 - 2.5e-06 26.9 0.1 6.2e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain DUF2025 PF09634.5 ESA19540.1 - 0.095 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2025) MIR PF02815.14 ESA19541.1 - 0.00022 20.8 0.3 0.024 14.1 0.0 2.6 1 1 2 3 3 3 2 MIR domain Ins145_P3_rec PF08709.6 ESA19541.1 - 0.03 13.3 0.8 0.13 11.2 0.0 2.0 1 1 1 2 2 2 0 Inositol 1,4,5-trisphosphate/ryanodine receptor p450 PF00067.17 ESA19547.1 - 1.3e-37 129.3 0.2 1.5e-37 129.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA19547.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) LRR_4 PF12799.2 ESA19548.1 - 4.9e-07 29.2 8.6 0.15 11.7 0.0 4.7 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA19548.1 - 4.9e-06 25.8 11.6 0.26 11.4 0.1 6.4 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.1 ESA19548.1 - 2e-05 24.2 11.7 0.35 11.0 0.1 6.0 5 1 0 5 5 5 3 Leucine Rich repeat LRR_7 PF13504.1 ESA19548.1 - 0.00016 21.3 11.1 0.2 11.9 0.2 5.3 5 1 0 5 5 5 2 Leucine rich repeat LRR_8 PF13855.1 ESA19548.1 - 0.0014 18.3 15.3 0.012 15.3 1.9 3.8 2 2 1 3 3 3 2 Leucine rich repeat p450 PF00067.17 ESA19549.1 - 1.2e-35 122.9 0.0 1.4e-35 122.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA19549.1 - 0.0015 18.4 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1811) DUF2457 PF10446.4 ESA19552.1 - 4.3 5.9 12.9 5.6 5.5 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.7 ESA19552.1 - 6.9 5.8 8.5 9.1 5.4 5.9 1.1 1 0 0 1 1 1 0 NOA36 protein AhpC-TSA PF00578.16 ESA19553.1 - 8.2e-34 115.9 0.0 1.2e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 ESA19553.1 - 2.1e-11 43.5 0.0 2.9e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.4 ESA19553.1 - 8.4e-11 41.3 0.0 1.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin DAHP_synth_2 PF01474.11 ESA19554.1 - 1.4e-193 643.1 0.0 1.6e-193 642.9 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Allantoicase PF03561.10 ESA19555.1 - 3.4e-100 331.7 0.1 1.3e-50 170.8 0.0 2.3 2 0 0 2 2 2 2 Allantoicase repeat Ureidogly_hydro PF04115.7 ESA19555.1 - 4.4e-42 143.2 0.0 1.1e-41 141.9 0.0 1.6 1 0 0 1 1 1 1 Ureidoglycolate hydrolase zf-H2C2_5 PF13909.1 ESA19556.1 - 0.1 12.8 3.1 0.37 11.0 0.8 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain SGT1 PF07093.6 ESA19558.1 - 0.0034 15.8 6.1 0.0036 15.7 4.2 1.1 1 0 0 1 1 1 1 SGT1 protein UBA_e1_C PF09358.5 ESA19560.1 - 0.12 12.5 0.1 0.13 12.4 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin-activating enzyme e1 C-terminal domain DUF3253 PF11625.3 ESA19562.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) IL13 PF03487.8 ESA19563.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Interleukin-13 p450 PF00067.17 ESA19565.1 - 8.2e-37 126.7 0.1 9e-37 126.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA19566.1 - 1.5e-20 73.2 0.0 2.8e-20 72.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Cas_Cmr5 PF09701.5 ESA19566.1 - 0.044 13.9 0.9 21 5.3 0.0 3.1 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cmr5) DUF3149 PF11346.3 ESA19566.1 - 0.14 11.7 1.2 0.32 10.6 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) p450 PF00067.17 ESA19567.1 - 0.016 13.7 0.0 0.019 13.5 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 p450 PF00067.17 ESA19568.1 - 3.9e-25 88.3 0.0 4.2e-25 88.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA19569.1 - 3.9e-07 28.9 0.1 4.1e-07 28.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1040 PF06288.8 ESA19569.1 - 0.14 12.3 0.4 0.2 11.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1040) Hemocyanin_C PF03723.9 ESA19572.1 - 3.6e-39 134.4 0.0 4.6e-39 134.0 0.0 1.0 1 0 0 1 1 1 1 Hemocyanin, ig-like domain Hemocyanin_C PF03723.9 ESA19573.1 - 5.9e-39 133.7 0.0 7.8e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Hemocyanin, ig-like domain IncA PF04156.9 ESA19575.1 - 0.0021 17.6 0.2 0.0021 17.6 0.1 2.1 2 1 0 2 2 2 1 IncA protein Med21 PF11221.3 ESA19575.1 - 0.0065 16.4 3.8 0.054 13.4 0.1 2.9 2 2 0 2 2 2 1 Subunit 21 of Mediator complex DUF417 PF04224.7 ESA19575.1 - 0.0072 15.7 0.2 0.013 14.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF417 SHP PF03579.8 ESA19578.1 - 0.13 11.5 0.8 0.78 9.1 0.0 2.2 2 0 0 2 2 2 0 Small hydrophobic protein LRR_6 PF13516.1 ESA19582.1 - 5.4e-23 78.4 41.4 0.0076 16.2 0.0 11.8 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.2 ESA19582.1 - 1.8e-06 27.3 43.2 0.0066 16.0 0.5 7.1 4 3 1 6 6 6 5 Leucine Rich repeats (2 copies) PRANC PF09372.5 ESA19582.1 - 0.0049 16.8 0.1 0.0049 16.8 0.1 4.5 4 1 1 5 5 5 1 PRANC domain F-box PF00646.28 ESA19582.1 - 0.0088 15.6 0.0 0.026 14.1 0.0 1.9 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.1 ESA19582.1 - 0.1 12.3 37.7 0.049 13.3 3.4 6.5 4 2 1 5 5 5 0 Leucine rich repeat LRR_1 PF00560.28 ESA19582.1 - 2.3 8.5 34.0 3.7 7.9 0.2 10.2 9 3 0 9 9 9 0 Leucine Rich Repeat DUF914 PF06027.7 ESA19584.1 - 4.1e-114 380.9 16.1 5.4e-114 380.5 11.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 ESA19584.1 - 2e-07 31.2 7.1 2e-07 31.2 5.0 3.3 2 2 1 3 3 3 2 Multidrug resistance efflux transporter UAA PF08449.6 ESA19584.1 - 4.6e-07 29.0 19.6 7.3e-07 28.3 13.6 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESA19584.1 - 0.00011 22.1 11.0 0.00011 22.1 7.6 2.6 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 ESA19584.1 - 0.011 15.3 3.5 0.011 15.3 2.5 2.7 2 2 0 2 2 2 0 Triose-phosphate Transporter family HMG_box PF00505.14 ESA19585.1 - 0.0034 17.6 1.0 0.0034 17.6 0.7 2.1 2 1 0 2 2 2 1 HMG (high mobility group) box AAA_21 PF13304.1 ESA19585.1 - 0.49 10.3 5.8 0.54 10.1 4.0 1.0 1 0 0 1 1 1 0 AAA domain Enhancin PF03272.8 ESA19586.1 - 0.012 13.5 2.7 0.012 13.5 1.9 1.0 1 0 0 1 1 1 0 Viral enhancin protein F-box-like PF12937.2 ESA19587.1 - 4.6e-09 35.8 0.0 9.3e-09 34.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19587.1 - 2e-06 27.3 0.0 3.7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 F-box domain TFIIA PF03153.8 ESA19587.1 - 0.0017 18.3 2.3 0.0017 18.3 1.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Lactamase_B PF00753.22 ESA19588.1 - 3.3e-31 108.4 0.3 4e-31 108.1 0.2 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 ESA19588.1 - 4.3e-06 26.3 0.3 8.9e-06 25.3 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Choline_transpo PF04515.7 ESA19591.1 - 3.4e-83 279.1 30.7 3.4e-83 279.1 15.7 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter DUF4064 PF13273.1 ESA19591.1 - 0.0091 16.0 4.8 0.0091 16.0 3.3 4.3 3 2 2 5 5 5 1 Protein of unknown function (DUF4064) DUF3317 PF11779.3 ESA19595.1 - 2e-06 27.0 0.3 2.7e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3317) Phage_hub_GP28 PF11110.3 ESA19598.1 - 0.02 14.5 4.1 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Baseplate hub distal subunit SMC_Nse1 PF07574.8 ESA19598.1 - 0.027 14.1 8.3 0.17 11.5 4.6 2.1 1 1 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex RNA_pol_Rpc4 PF05132.9 ESA19598.1 - 0.25 11.3 4.3 0.48 10.4 3.0 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF848 PF05852.6 ESA19598.1 - 6.9 6.5 14.2 0.77 9.6 6.3 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF904 PF06005.7 ESA19600.1 - 0.0014 18.8 10.0 0.0014 18.8 6.9 2.6 2 1 1 3 3 2 2 Protein of unknown function (DUF904) Phlebovirus_NSM PF07246.6 ESA19600.1 - 0.023 13.8 0.7 0.059 12.5 0.5 1.7 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ATG16 PF08614.6 ESA19600.1 - 0.024 14.4 8.4 0.087 12.6 5.8 2.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 ESA19600.1 - 0.053 13.4 4.3 0.25 11.3 1.4 2.8 1 1 1 2 2 2 0 bZIP transcription factor DASH_Dam1 PF08653.5 ESA19600.1 - 0.083 12.6 0.6 0.25 11.1 0.4 1.9 1 0 0 1 1 1 0 DASH complex subunit Dam1 HALZ PF02183.13 ESA19600.1 - 0.09 12.5 6.9 5.3 6.8 0.5 3.9 2 1 1 3 3 3 0 Homeobox associated leucine zipper HemX PF04375.9 ESA19600.1 - 0.095 11.2 3.1 0.19 10.2 2.1 1.4 1 0 0 1 1 1 0 HemX CCDC155 PF14662.1 ESA19600.1 - 0.18 11.4 8.2 0.061 12.9 3.6 1.8 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 DUF848 PF05852.6 ESA19600.1 - 0.26 11.1 6.9 0.091 12.6 2.5 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Kinesin-relat_1 PF12711.2 ESA19600.1 - 0.3 11.5 6.2 6.2 7.2 3.6 3.0 2 1 0 2 2 2 0 Kinesin motor TSC22 PF01166.13 ESA19600.1 - 0.35 10.8 14.2 0.65 10.0 0.5 4.1 3 1 2 5 5 5 0 TSC-22/dip/bun family DivIC PF04977.10 ESA19600.1 - 0.36 10.3 11.0 0.08 12.4 2.5 2.9 2 1 1 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.3 ESA19600.1 - 0.38 10.5 7.6 0.92 9.3 5.2 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.4 ESA19600.1 - 0.38 10.9 5.5 1.1 9.4 3.8 1.8 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IncA PF04156.9 ESA19600.1 - 0.55 9.8 9.6 0.58 9.7 5.5 1.9 1 1 0 1 1 1 0 IncA protein DUF972 PF06156.8 ESA19600.1 - 0.56 10.5 10.6 0.063 13.6 3.2 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF972) CENP-H PF05837.7 ESA19600.1 - 2.4 8.3 14.8 0.069 13.3 3.8 2.9 1 1 1 3 3 3 0 Centromere protein H (CENP-H) YlqD PF11068.3 ESA19600.1 - 3.9 7.5 11.7 1.7 8.6 4.6 2.5 2 0 0 2 2 2 0 YlqD protein Myb_DNA-binding PF00249.26 ESA19602.1 - 0.066 13.2 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Lipase_3 PF01764.20 ESA19604.1 - 5.3e-19 68.2 0.0 9.2e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 ESA19604.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.3 ESA19604.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.15 ESA19604.1 - 0.09 12.3 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESA19604.1 - 0.12 12.2 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Med8 PF10232.4 ESA19605.1 - 0.08 12.4 0.8 0.13 11.7 0.6 1.3 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 zf-RVT PF13966.1 ESA19606.1 - 0.061 13.6 1.3 0.34 11.2 0.1 2.2 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase DDE_1 PF03184.14 ESA19608.1 - 1.8e-47 161.2 0.1 2.7e-47 160.7 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA19608.1 - 0.0026 17.5 0.1 0.0049 16.6 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA19608.1 - 0.027 14.2 0.0 0.04 13.6 0.0 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF2861 PF11060.3 ESA19609.1 - 0.0092 15.3 0.1 0.011 15.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2861) HTH_Tnp_Tc5 PF03221.11 ESA19610.1 - 0.00045 19.9 0.1 0.00062 19.5 0.0 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA19611.1 - 2.9e-25 88.6 0.0 4.2e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA19611.1 - 0.028 14.2 0.2 0.054 13.3 0.1 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA19612.1 - 1.9e-24 86.0 0.0 3.1e-24 85.3 0.0 1.3 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA19612.1 - 0.0033 17.1 0.2 0.0051 16.5 0.1 1.3 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain End_tail_spike PF12219.3 ESA19613.1 - 0.046 13.5 0.1 0.047 13.5 0.1 1.0 1 0 0 1 1 1 0 Catalytic domain of bacteriophage endosialidase DUF3684 PF12449.3 ESA19615.1 - 1.5e-235 784.4 8.4 3.4e-233 776.6 2.8 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA19615.1 - 7.3e-05 22.4 0.0 0.00021 20.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.5 ESA19615.1 - 0.11 12.3 4.7 0.19 11.5 2.5 1.9 2 0 0 2 2 2 0 WLM domain DUF3684 PF12449.3 ESA19616.1 - 6.2e-236 785.7 3.8 1.2e-231 771.5 0.8 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA19616.1 - 5e-05 22.9 0.0 0.00016 21.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAP_assoc PF03828.14 ESA19618.1 - 1.9e-15 56.5 0.0 9.3e-15 54.3 0.0 2.3 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 ESA19618.1 - 1.5e-05 25.2 0.0 3.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Asp_protease_2 PF13650.1 ESA19619.1 - 1.6e-10 41.3 0.1 2.5e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 ESA19619.1 - 7.3e-09 35.2 0.2 1.1e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA19619.1 - 9e-09 35.3 0.1 1.2e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA19619.1 - 4.4e-07 29.6 0.0 7.3e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.15 ESA19619.1 - 2.6e-06 27.2 0.6 4.9e-06 26.3 0.4 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Peptidase_A2B PF12384.3 ESA19619.1 - 0.014 14.7 0.1 0.019 14.2 0.1 1.2 1 0 0 1 1 1 0 Ty3 transposon peptidase Na_trans_assoc PF06512.8 ESA19619.1 - 0.028 14.3 9.8 0.032 14.1 6.8 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Arch_ATPase PF01637.13 ESA19620.1 - 0.0001 22.1 0.0 0.00039 20.2 0.0 1.9 1 1 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 ESA19620.1 - 0.00019 21.5 0.0 0.087 12.9 0.0 2.9 2 1 0 3 3 3 2 AAA domain AAA_19 PF13245.1 ESA19620.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain Queuosine_synth PF02547.10 ESA19621.1 - 0.0091 14.7 0.0 0.018 13.7 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein RsbU_N PF08673.5 ESA19623.1 - 0.044 13.7 0.0 0.048 13.6 0.0 1.1 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain Inhibitor_I29 PF08246.7 ESA19624.1 - 0.0014 18.8 0.4 0.99 9.7 0.1 2.3 2 0 0 2 2 2 2 Cathepsin propeptide inhibitor domain (I29) Nucleoporin2 PF04096.9 ESA19624.1 - 0.0087 15.8 0.6 0.011 15.5 0.4 1.2 1 0 0 1 1 1 1 Nucleoporin autopeptidase Imm11 PF15563.1 ESA19624.1 - 0.038 13.1 1.5 2.4 7.2 0.2 2.1 1 1 1 2 2 2 0 Immunity protein 11 SAP30_Sin3_bdg PF13867.1 ESA19624.1 - 0.13 12.1 0.6 5.4 6.9 0.0 2.4 1 1 1 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 tRNA_SAD PF07973.9 ESA19624.1 - 0.14 12.0 3.0 0.82 9.6 0.1 2.5 3 0 0 3 3 3 0 Threonyl and Alanyl tRNA synthetase second additional domain Methyltransf_11 PF08241.7 ESA19625.1 - 7.2e-12 45.6 0.0 9.6e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA19625.1 - 3e-10 39.8 0.0 1.5e-09 37.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA19625.1 - 1.7e-09 37.9 0.0 2.8e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA19625.1 - 7.5e-09 35.5 0.0 9e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA19625.1 - 3.5e-06 27.5 0.0 1.5e-05 25.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA19625.1 - 8.2e-06 25.3 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 ESA19625.1 - 3.2e-05 23.1 0.0 0.00016 20.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA19625.1 - 5.8e-05 23.4 0.0 9.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA19625.1 - 0.00022 20.4 0.0 0.00037 19.7 0.0 1.3 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 ESA19625.1 - 0.00024 20.1 0.0 0.00035 19.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA19625.1 - 0.00042 20.3 0.0 0.00097 19.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF3805 PF12712.2 ESA19625.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3805) FtsJ PF01728.14 ESA19625.1 - 0.1 12.5 0.0 0.19 11.7 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase DUF4451 PF14616.1 ESA19627.1 - 0.081 12.6 0.1 0.095 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Asp_protease_2 PF13650.1 ESA19628.1 - 1.4e-09 38.2 0.2 2.1e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.5 ESA19628.1 - 1.1e-07 31.4 0.2 1.7e-07 30.8 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA19628.1 - 1.7e-07 31.2 0.0 2.1e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.15 ESA19628.1 - 1.9e-06 27.7 1.0 3.2e-06 26.9 0.7 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA19628.1 - 9.3e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Na_trans_assoc PF06512.8 ESA19628.1 - 0.083 12.8 10.1 0.087 12.7 7.0 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Lin-8 PF03353.10 ESA19628.1 - 3.1 7.0 15.0 3.8 6.7 10.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ku_C PF03730.9 ESA19628.1 - 6.5 7.3 9.3 2 8.9 3.8 2.0 2 1 1 3 3 3 0 Ku70/Ku80 C-terminal arm Acyltransferase PF01553.16 ESA19629.1 - 2.8e-18 65.6 0.1 4.4e-18 64.9 0.1 1.3 1 0 0 1 1 1 1 Acyltransferase Vfa1 PF08432.5 ESA19630.1 - 0.045 13.7 4.9 0.067 13.2 3.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.4 ESA19630.1 - 8 5.0 14.2 11 4.5 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NatB_MDM20 PF09797.4 ESA19631.1 - 2.2e-79 266.8 18.4 2.2e-79 266.8 12.8 2.8 3 0 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_11 PF13414.1 ESA19631.1 - 1.6e-08 34.0 5.0 0.011 15.3 0.1 5.0 5 0 0 5 5 5 2 TPR repeat TPR_16 PF13432.1 ESA19631.1 - 5e-08 33.4 0.0 0.0015 19.1 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA19631.1 - 1.8e-07 31.3 13.7 0.015 15.6 0.1 6.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 ESA19631.1 - 4.3e-07 29.9 0.0 0.055 14.1 0.0 6.2 5 1 2 7 7 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA19631.1 - 4.6e-07 29.1 0.2 0.13 11.9 0.0 5.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA19631.1 - 1.2e-06 27.8 0.1 0.04 13.7 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA19631.1 - 1.5e-06 28.2 9.7 0.0033 17.5 0.1 5.4 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA19631.1 - 1.8e-06 27.3 0.1 2.4 8.3 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.1 ESA19631.1 - 4.4e-05 22.6 1.4 0.054 12.5 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA19631.1 - 0.0048 16.5 3.3 3.3 7.7 0.0 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA19631.1 - 0.01 16.2 2.4 8.7 7.0 0.0 5.2 8 0 0 8 8 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA19631.1 - 0.017 15.0 2.0 1.2 9.0 0.0 4.5 4 1 2 6 6 6 0 Tetratricopeptide repeat NARP1 PF12569.3 ESA19631.1 - 0.02 13.6 34.3 0.21 10.2 0.5 3.8 3 1 1 4 4 4 0 NMDA receptor-regulated protein 1 TPR_17 PF13431.1 ESA19631.1 - 0.031 14.4 1.1 34 4.9 0.1 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA19631.1 - 0.034 14.0 3.3 0.2 11.5 0.2 3.4 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.12 ESA19631.1 - 0.048 13.9 0.1 0.92 9.8 0.0 2.7 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TraH_2 PF06871.6 ESA19631.1 - 0.56 9.6 2.5 1.2 8.5 1.7 1.5 1 0 0 1 1 1 0 TraH_2 ECH PF00378.15 ESA19632.1 - 1.8e-50 171.4 0.0 2.5e-50 170.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 ESA19632.1 - 0.01 15.6 0.0 0.03 14.0 0.0 1.7 2 0 0 2 2 2 0 Peptidase family S49 BTB PF00651.26 ESA19633.1 - 9.6e-13 48.0 0.4 1.9e-12 47.1 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA19633.1 - 0.029 14.1 0.0 0.63 9.8 0.0 2.4 1 1 1 2 2 2 0 BTB And C-terminal Kelch BTB PF00651.26 ESA19634.1 - 0.0026 17.7 1.4 0.45 10.5 0.0 3.5 3 0 0 3 3 3 1 BTB/POZ domain Fer4_12 PF13353.1 ESA19634.1 - 0.017 15.2 2.7 0.022 14.8 0.6 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Imm3 PF14425.1 ESA19634.1 - 5.1 7.0 10.4 0.81 9.6 0.1 4.0 3 1 1 4 4 4 0 Immunity protein Imm3 NTNH_C PF08470.5 ESA19635.1 - 0.064 12.8 0.2 0.1 12.2 0.2 1.3 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal Mor PF08765.6 ESA19636.1 - 0.33 10.7 2.6 0.38 10.5 0.1 2.3 3 0 0 3 3 3 0 Mor transcription activator family STAT_int PF02865.12 ESA19636.1 - 1.2 9.1 8.6 0.66 9.9 0.4 2.9 1 1 2 3 3 3 0 STAT protein, protein interaction domain DUF1399 PF07173.7 ESA19636.1 - 1.4 9.2 8.2 0.77 10.0 0.9 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1399) Vps39_2 PF10367.4 ESA19636.1 - 9.8 6.4 7.8 1.3 9.2 0.8 2.7 2 2 1 3 3 3 0 Vacuolar sorting protein 39 domain 2 Asp_protease_2 PF13650.1 ESA19639.1 - 1.6e-09 38.1 0.2 2.8e-09 37.3 0.1 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA19639.1 - 6.5e-08 32.5 0.1 8.7e-08 32.1 0.1 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA19639.1 - 8.4e-08 31.8 0.5 1.2e-07 31.2 0.4 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA19639.1 - 2.3e-06 27.4 1.1 4.5e-06 26.4 0.6 1.6 1 1 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA19639.1 - 0.00011 21.8 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Pirin PF02678.11 ESA19642.1 - 1.7e-31 108.2 0.4 2.8e-31 107.5 0.3 1.4 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.6 ESA19642.1 - 9.7e-06 25.0 1.7 5.1e-05 22.6 0.4 2.2 2 0 0 2 2 2 1 Cupin domain DnaJ_CXXCXGXG PF00684.14 ESA19643.1 - 0.028 14.4 19.2 0.098 12.7 13.3 1.8 1 1 1 2 2 2 0 DnaJ central domain zf-HIT PF04438.11 ESA19643.1 - 0.028 14.0 3.1 0.028 14.0 2.2 2.5 2 1 1 3 3 3 0 HIT zinc finger TFIIS_C PF01096.13 ESA19643.1 - 1.5 8.5 0.1 1.5 8.5 0.1 3.0 3 1 1 4 4 4 0 Transcription factor S-II (TFIIS) Zn_ribbon_recom PF13408.1 ESA19643.1 - 2.3 8.5 14.2 2 8.7 2.0 2.4 1 1 2 3 3 3 0 Recombinase zinc beta ribbon domain DUF1356 PF07092.7 ESA19643.1 - 9.7 5.2 10.5 1 8.4 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) Serinc PF03348.10 ESA19644.1 - 8.2e-147 489.3 10.7 1e-146 489.0 7.4 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) Neurensin PF14927.1 ESA19644.1 - 0.64 9.4 6.1 1.6 8.1 0.0 3.4 2 1 1 3 3 3 0 Neurensin DUF775 PF05603.7 ESA19646.1 - 6e-50 169.5 0.2 7.4e-50 169.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Methyltransf_23 PF13489.1 ESA19647.1 - 0.00021 21.0 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA19647.1 - 0.00083 19.7 0.0 0.0016 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Asp_protease_2 PF13650.1 ESA19648.1 - 1.1e-09 38.6 0.2 1.7e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA19648.1 - 2.1e-07 30.9 0.0 2.7e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA19648.1 - 2.2e-07 30.4 0.3 3.4e-07 29.8 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA19648.1 - 1.8e-06 27.8 1.0 3.4e-06 26.8 0.7 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA19648.1 - 9.5e-05 22.1 0.0 0.00015 21.5 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Na_trans_assoc PF06512.8 ESA19648.1 - 0.012 15.5 8.9 0.013 15.4 6.2 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Blt1 PF12754.2 ESA19648.1 - 0.026 14.1 1.5 0.034 13.7 1.0 1.2 1 0 0 1 1 1 0 Cell-cycle control medial ring component TSC22 PF01166.13 ESA19648.1 - 0.63 10.0 7.1 2.3 8.2 0.5 3.3 3 1 0 3 3 3 0 TSC-22/dip/bun family Pkinase_Tyr PF07714.12 ESA19649.1 - 0.00012 21.2 0.0 0.0002 20.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19649.1 - 0.0059 15.7 0.2 0.014 14.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain vWF_A PF12450.3 ESA19649.1 - 0.021 14.5 0.0 0.063 12.9 0.1 1.8 2 0 0 2 2 2 0 von Willebrand factor RabGAP-TBC PF00566.13 ESA19649.1 - 0.033 13.6 1.3 0.052 13.0 0.7 1.3 1 1 0 1 1 1 0 Rab-GTPase-TBC domain zf-CCHC PF00098.18 ESA19653.1 - 0.00053 19.7 1.8 0.00097 18.9 1.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.1 ESA19653.1 - 0.0013 18.1 2.0 0.0023 17.3 1.4 1.3 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger TLD PF07534.11 ESA19655.1 - 1.7e-06 28.0 2.7 1.7e-05 24.8 1.9 1.9 1 1 0 1 1 1 1 TLD fn2 PF00040.14 ESA19655.1 - 0.017 15.0 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type II domain Tna_leader PF08053.6 ESA19655.1 - 0.16 11.3 1.6 0.19 11.1 0.1 1.9 2 0 0 2 2 2 0 Tryptophanese operon leader peptide TPX2 PF06886.6 ESA19656.1 - 2.4e-09 37.1 14.5 2.4e-09 37.1 10.0 2.8 4 0 0 4 4 4 1 Targeting protein for Xklp2 (TPX2) V_ATPase_I PF01496.14 ESA19656.1 - 1.8 6.3 5.5 2.1 6.0 3.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pkinase PF00069.20 ESA19657.1 - 6.5e-37 127.0 0.1 8.4e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19657.1 - 2.6e-35 121.7 0.0 3.1e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA19657.1 - 0.00077 18.8 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA19657.1 - 0.0032 17.2 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA19657.1 - 0.016 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA19657.1 - 0.027 13.7 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.15 ESA19657.1 - 0.039 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Asp_protease_2 PF13650.1 ESA19658.1 - 1.2e-10 41.7 0.2 1.6e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA19658.1 - 2e-07 31.0 0.0 2.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA19658.1 - 4.5e-07 29.4 0.3 6.5e-07 28.9 0.2 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA19658.1 - 3.6e-06 26.8 1.8 5.5e-06 26.2 1.2 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA19658.1 - 1.5e-05 24.6 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease FNIP PF05725.7 ESA19660.1 - 2.1e-05 24.3 6.2 0.83 9.6 0.0 5.6 4 1 1 5 5 5 3 FNIP Repeat F-box PF00646.28 ESA19660.1 - 0.0094 15.5 2.4 0.018 14.7 0.5 2.3 2 0 0 2 2 2 1 F-box domain Cdd1 PF11731.3 ESA19660.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity locus F-box-like PF12937.2 ESA19660.1 - 0.11 12.2 1.2 0.39 10.4 0.8 2.0 1 0 0 1 1 1 0 F-box-like Bromodomain PF00439.20 ESA19661.1 - 1.9e-19 69.3 0.3 3.1e-19 68.6 0.2 1.3 1 0 0 1 1 1 1 Bromodomain zf-CCHC_6 PF15288.1 ESA19661.1 - 9.2e-07 28.4 1.7 1.8e-06 27.5 1.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.18 ESA19661.1 - 0.038 13.9 1.9 0.038 13.9 1.3 1.7 2 0 0 2 2 2 0 Zinc knuckle TraK PF06586.6 ESA19662.1 - 0.026 13.6 8.7 0.12 11.4 0.1 2.9 3 0 0 3 3 3 0 TraK protein Rho_RNA_bind PF07497.7 ESA19662.1 - 0.12 12.0 3.6 0.62 9.7 0.1 2.5 2 0 0 2 2 2 0 Rho termination factor, RNA-binding domain Pet127 PF08634.5 ESA19663.1 - 0.0024 17.0 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 BON PF04972.12 ESA19663.1 - 0.14 11.8 0.1 1.5 8.6 0.0 2.0 1 1 1 2 2 2 0 BON domain Toxin_67 PF15545.1 ESA19663.1 - 0.27 11.1 3.9 5.4 6.9 0.1 2.6 2 1 1 3 3 3 0 Putative toxin 67 CBM_20 PF00686.14 ESA19665.1 - 0.0014 18.2 0.0 0.0033 17.0 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain TusA PF01206.12 ESA19667.1 - 0.031 13.8 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Sulfurtransferase TusA Macscav_rec PF03523.8 ESA19667.1 - 0.1 12.3 0.2 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Macrophage scavenger receptor DDE_Tnp_ISAZ013 PF07592.6 ESA19668.1 - 8.1e-08 31.3 0.0 3.8e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain Snapin_Pallidin PF14712.1 ESA19668.1 - 0.048 13.9 2.6 0.15 12.3 1.8 1.8 1 0 0 1 1 1 0 Snapin/Pallidin zf-C2H2 PF00096.21 ESA19669.1 - 0.0032 17.7 0.9 0.009 16.3 0.6 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA19669.1 - 0.044 14.1 0.3 0.12 12.7 0.2 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger SASRP1 PF15160.1 ESA19669.1 - 0.062 12.5 0.2 0.09 11.9 0.1 1.3 1 1 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 Arc_trans_TRASH PF08394.5 ESA19669.1 - 2.9 8.1 5.0 14 5.8 1.3 2.7 2 0 0 2 2 2 0 Archaeal TRASH domain Toxin_56 PF15534.1 ESA19670.1 - 0.0097 16.3 0.1 0.48 10.9 0.0 3.5 3 0 0 3 3 3 1 Putative toxin 56 DDE_Tnp_ISAZ013 PF07592.6 ESA19671.1 - 4.8e-05 22.2 0.0 0.22 10.2 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain YdjO PF14169.1 ESA19672.1 - 1.4 8.4 5.0 1.8 8.0 0.0 2.7 3 0 0 3 3 3 0 Cold-inducible protein YdjO DUF3141 PF11339.3 ESA19674.1 - 0.13 10.5 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DUF1117 PF06547.7 ESA19677.1 - 0.091 12.8 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) Spc97_Spc98 PF04130.8 ESA19678.1 - 1.6e-78 264.3 6.1 1.8e-78 264.2 4.2 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family AICARFT_IMPCHas PF01808.13 ESA19678.1 - 0.022 13.8 0.0 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme Fic_N PF13784.1 ESA19679.1 - 0.14 12.0 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 Fic/DOC family N-terminal zf-C2H2 PF00096.21 ESA19681.1 - 5.9e-10 38.8 19.8 9.3e-05 22.5 1.6 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA19681.1 - 9.4e-09 35.1 12.4 4.3e-08 33.0 2.9 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA19681.1 - 0.00023 21.2 17.1 0.024 14.9 1.0 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA19681.1 - 0.0029 17.4 12.5 0.99 9.4 0.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger XPA_N PF01286.13 ESA19681.1 - 0.012 15.2 0.5 0.012 15.2 0.3 2.5 3 0 0 3 3 3 0 XPA protein N-terminal Phage_int_SAM_3 PF14659.1 ESA19681.1 - 0.14 12.4 2.8 11 6.3 0.0 2.5 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain zf-C2H2_jaz PF12171.3 ESA19681.1 - 0.22 11.7 10.0 0.63 10.2 0.4 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 ESA19681.1 - 6.6 6.7 7.8 2.6 8.0 1.2 3.0 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2HC_2 PF13913.1 ESA19681.1 - 8.1 6.2 13.5 1.9 8.2 0.7 3.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Trypsin_2 PF13365.1 ESA19684.1 - 0.11 12.5 0.0 0.35 10.8 0.0 1.8 1 1 0 1 1 1 0 Trypsin-like peptidase domain HCV_NS5a_C PF12941.2 ESA19687.1 - 0.054 13.0 0.0 0.054 13.0 0.0 1.0 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region bPH_1 PF08000.6 ESA19688.1 - 0.12 12.0 2.6 0.18 11.4 1.8 1.3 1 0 0 1 1 1 0 Bacterial PH domain DUF1126 PF06565.7 ESA19688.1 - 9.1 5.8 8.5 0.94 9.0 0.8 2.2 2 0 0 2 2 2 0 Repeat of unknown function (DUF1126) Phage_GP20 PF06810.6 ESA19689.1 - 0.0032 16.9 1.8 0.0071 15.8 0.2 2.0 2 0 0 2 2 2 1 Phage minor structural protein GP20 bZIP_1 PF00170.16 ESA19689.1 - 0.041 13.8 0.7 0.093 12.6 0.5 1.6 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.10 ESA19689.1 - 2.5 7.9 5.0 0.27 11.1 0.2 1.8 2 0 0 2 2 2 0 Basic region leucine zipper tRNA-synt_2b PF00587.20 ESA19690.1 - 8.6e-38 129.6 0.0 1.4e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA19690.1 - 5.4e-13 48.7 0.0 1.7e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 Anticodon binding domain Rep_4 PF05797.6 ESA19693.1 - 0.0022 16.7 0.4 0.0026 16.5 0.3 1.1 1 0 0 1 1 1 1 Yeast trans-acting factor (REP1/REP2) DUF1436 PF07262.6 ESA19694.1 - 0.045 13.2 1.2 0.063 12.7 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1436) MTH865 PF07747.6 ESA19695.1 - 0.094 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 MTH865-like family Pkinase_Tyr PF07714.12 ESA19696.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF925 PF06042.6 ESA19698.1 - 0.0074 15.8 0.1 0.012 15.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF925) Kunitz_BPTI PF00014.18 ESA19698.1 - 0.034 14.3 0.6 0.075 13.2 0.4 1.6 1 0 0 1 1 1 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Mad3_BUB1_I PF08311.7 ESA19698.1 - 0.15 11.8 2.4 0.25 11.1 1.6 1.4 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 zf-RING_5 PF14634.1 ESA19699.1 - 0.004 16.8 4.4 0.0084 15.8 2.7 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA19699.1 - 0.009 15.6 3.0 0.017 14.8 2.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UPF0547 PF10571.4 ESA19699.1 - 0.076 12.7 0.5 0.29 10.8 0.1 2.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-RING_2 PF13639.1 ESA19699.1 - 0.21 11.4 3.0 0.4 10.5 2.1 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 ESA19699.1 - 0.34 10.6 8.8 0.49 10.1 4.7 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.1 ESA19700.1 - 0.0072 15.9 2.5 0.013 15.1 1.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA19700.1 - 0.019 14.6 2.5 0.036 13.8 1.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 ESA19700.1 - 0.92 9.3 3.2 1.7 8.5 2.2 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 ESA19700.1 - 1.6 8.5 5.9 6.8 6.5 4.1 2.2 1 0 0 1 1 1 0 RING-type zinc-finger Herpes_ori_bp PF02399.10 ESA19702.1 - 7.2e-11 40.8 2.2 3e-08 32.1 0.3 2.9 2 1 1 3 3 3 2 Origin of replication binding protein Isochorismatase PF00857.15 ESA19702.1 - 0.0012 18.7 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Isochorismatase family AAA_11 PF13086.1 ESA19702.1 - 0.042 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA19702.1 - 0.085 13.0 0.1 3.7 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain HSP20 PF00011.16 ESA19704.1 - 3.5e-18 65.3 0.1 4.2e-18 65.1 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Chromate_transp PF02417.10 ESA19705.1 - 3.4e-59 199.2 38.1 4.6e-33 114.1 7.8 2.4 2 1 0 2 2 2 2 Chromate transporter Pkinase PF00069.20 ESA19708.1 - 1.1e-37 129.6 1.6 2e-36 125.5 0.1 2.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19708.1 - 1e-35 123.0 0.0 1.7e-34 119.1 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 ESA19708.1 - 0.15 11.7 0.1 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TFIIA_gamma_N PF02268.11 ESA19708.1 - 0.91 9.1 7.0 30 4.3 0.0 5.3 6 0 0 6 6 6 0 Transcription initiation factor IIA, gamma subunit, helical domain Abhydrolase_6 PF12697.2 ESA19709.1 - 1.2e-11 44.9 0.0 1.6e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA19709.1 - 0.0033 17.0 0.0 0.0058 16.2 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA19710.1 - 2.1e-11 43.7 0.0 2.6e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA19710.1 - 1.2e-08 35.1 0.0 0.00042 20.2 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESA19710.1 - 8.9e-06 25.3 0.0 1.6e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESA19710.1 - 0.00088 18.8 2.9 0.31 10.5 0.6 3.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.8 ESA19710.1 - 0.0062 16.0 0.0 0.0092 15.4 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 ESA19710.1 - 0.011 15.5 0.0 0.035 13.9 0.0 1.8 1 1 0 1 1 1 0 Putative lysophospholipase DUF2305 PF10230.4 ESA19710.1 - 0.047 13.1 0.2 0.5 9.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2305) DUF4283 PF14111.1 ESA19710.1 - 0.083 11.9 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) Abhydrolase_2 PF02230.11 ESA19710.1 - 0.095 12.1 0.3 0.9 8.9 0.2 2.2 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.13 ESA19710.1 - 0.11 11.8 0.0 0.26 10.5 0.0 1.9 1 1 0 1 1 1 0 Dienelactone hydrolase family KTI12 PF08433.5 ESA19711.1 - 0.09 11.9 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 SopA_C PF13979.1 ESA19712.1 - 0.048 13.2 0.1 0.048 13.2 0.1 1.0 1 0 0 1 1 1 0 SopA-like catalytic domain ASL_C PF08328.6 ESA19713.1 - 0.059 13.2 1.1 0.097 12.5 0.1 1.9 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal Prok-RING_4 PF14447.1 ESA19715.1 - 0.048 13.1 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 p450 PF00067.17 ESA19716.1 - 0.0073 14.8 3.2 0.009 14.5 2.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 FimP PF09766.4 ESA19716.1 - 0.0073 15.4 3.3 0.0076 15.3 2.3 1.1 1 0 0 1 1 1 1 Fms-interacting protein Sporozoite_P67 PF05642.6 ESA19716.1 - 0.042 11.7 3.3 0.049 11.5 2.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ETRAMP PF09716.5 ESA19716.1 - 0.15 11.9 2.4 0.31 11.0 1.7 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ETF_QO PF05187.8 ESA19716.1 - 0.17 11.8 1.4 0.27 11.2 1.0 1.3 1 0 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase Pex14_N PF04695.8 ESA19716.1 - 0.2 11.6 5.2 0.31 11.0 3.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2457 PF10446.4 ESA19716.1 - 0.54 8.9 4.0 0.67 8.6 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Menin PF05053.8 ESA19716.1 - 0.56 8.3 5.5 0.62 8.1 3.8 1.2 1 0 0 1 1 1 0 Menin Claudin_2 PF13903.1 ESA19716.1 - 0.7 9.5 7.0 1.1 8.9 4.9 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Macoilin PF09726.4 ESA19716.1 - 2.9 6.0 8.4 3.1 5.9 5.8 1.0 1 0 0 1 1 1 0 Transmembrane protein Pap_E4 PF02711.9 ESA19716.1 - 4.3 8.2 7.3 9.1 7.1 5.1 1.7 1 1 0 1 1 1 0 E4 protein CorA PF01544.13 ESA19719.1 - 0.12 11.4 0.7 0.37 9.7 0.2 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DivIC PF04977.10 ESA19719.1 - 0.39 10.2 14.8 0.29 10.6 1.7 3.5 2 1 1 3 3 3 0 Septum formation initiator Lge1 PF11488.3 ESA19719.1 - 0.71 10.1 13.2 1.4 9.1 0.6 3.3 1 1 2 3 3 3 0 Transcriptional regulatory protein LGE1 bZIP_2 PF07716.10 ESA19719.1 - 0.83 9.5 19.9 1.9 8.3 0.3 4.6 3 1 1 4 4 4 0 Basic region leucine zipper NYD-SP28_assoc PF14775.1 ESA19719.1 - 2 8.1 5.8 2.7 7.7 0.3 3.0 1 1 2 3 3 3 0 Sperm tail C-terminal domain DUF972 PF06156.8 ESA19719.1 - 3.7 7.9 14.8 0.12 12.7 1.1 3.4 2 2 2 4 4 4 0 Protein of unknown function (DUF972) HALZ PF02183.13 ESA19719.1 - 6.1 6.6 10.2 6.6 6.5 1.5 3.5 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 ESA19720.1 - 0.00012 22.3 10.6 0.0021 18.3 2.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF972) DUF904 PF06005.7 ESA19720.1 - 0.00013 22.1 14.0 0.019 15.2 4.5 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF904) DivIC PF04977.10 ESA19720.1 - 0.00015 21.1 10.6 0.044 13.2 2.4 2.3 1 1 1 2 2 2 2 Septum formation initiator bZIP_1 PF00170.16 ESA19720.1 - 0.00016 21.5 10.5 0.0091 15.9 2.7 2.6 2 0 0 2 2 2 2 bZIP transcription factor HALZ PF02183.13 ESA19720.1 - 0.013 15.2 8.5 0.025 14.2 0.6 3.2 2 1 1 3 3 3 0 Homeobox associated leucine zipper CCDC155 PF14662.1 ESA19720.1 - 0.017 14.7 8.4 0.026 14.1 5.8 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 DUF3166 PF11365.3 ESA19720.1 - 0.032 14.6 6.1 0.27 11.7 0.8 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3166) CENP-H PF05837.7 ESA19720.1 - 0.066 13.3 6.8 0.14 12.3 4.7 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) BRE1 PF08647.6 ESA19720.1 - 0.081 12.9 12.5 0.063 13.2 5.8 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Rootletin PF15035.1 ESA19720.1 - 0.12 12.3 4.3 0.31 11.0 0.7 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion bZIP_2 PF07716.10 ESA19720.1 - 0.13 12.1 13.6 3.3 7.5 0.4 3.3 2 1 1 3 3 3 0 Basic region leucine zipper TSC22 PF01166.13 ESA19720.1 - 0.13 12.1 8.1 0.094 12.6 1.2 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF3186 PF11382.3 ESA19720.1 - 0.22 10.5 2.2 0.28 10.2 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) Ribosomal_L29 PF00831.18 ESA19720.1 - 0.23 11.1 0.2 0.23 11.1 0.2 2.6 2 1 0 2 2 2 0 Ribosomal L29 protein Fib_alpha PF08702.5 ESA19720.1 - 0.29 11.2 6.5 0.28 11.2 3.9 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Nup54 PF13874.1 ESA19720.1 - 0.3 10.7 4.3 0.4 10.3 1.8 1.8 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF1875 PF08961.5 ESA19720.1 - 0.41 9.9 5.1 0.66 9.2 3.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1875) BLOC1_2 PF10046.4 ESA19720.1 - 0.42 10.7 9.8 0.28 11.3 1.8 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6 PF04111.7 ESA19720.1 - 0.5 9.3 7.4 0.53 9.2 5.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF724 PF05266.9 ESA19720.1 - 0.54 9.8 7.9 0.68 9.5 5.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF2935 PF11155.3 ESA19720.1 - 0.54 10.3 6.8 0.83 9.7 4.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Shugoshin_N PF07558.6 ESA19720.1 - 0.77 9.5 11.9 6.7 6.5 3.3 3.8 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Seryl_tRNA_N PF02403.17 ESA19720.1 - 0.8 9.7 10.3 1.2 9.2 7.2 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Kinesin-relat_1 PF12711.2 ESA19720.1 - 0.99 9.8 7.0 2.1 8.8 2.6 2.4 1 1 2 3 3 3 0 Kinesin motor DUF4398 PF14346.1 ESA19720.1 - 1.1 9.3 5.1 4.2 7.4 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) TcdA_TcdB PF12919.2 ESA19720.1 - 1.1 7.6 7.7 1.2 7.4 5.4 1.0 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Spc24 PF08286.6 ESA19720.1 - 1.3 8.6 8.2 2.4 7.9 0.8 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF342 PF03961.8 ESA19720.1 - 1.5 7.1 8.3 1.5 7.1 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4337 PF14235.1 ESA19720.1 - 1.5 8.5 5.7 4.8 6.9 3.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) NYD-SP28_assoc PF14775.1 ESA19720.1 - 1.7 8.4 8.2 4.2 7.1 1.7 3.2 2 1 1 3 3 3 0 Sperm tail C-terminal domain Nnf1 PF03980.9 ESA19720.1 - 3.6 7.6 7.6 15 5.6 0.3 2.6 1 1 0 2 2 2 0 Nnf1 GrpE PF01025.14 ESA19720.1 - 5.1 6.6 10.0 4.5 6.7 3.7 2.0 1 1 1 2 2 2 0 GrpE TMF_DNA_bd PF12329.3 ESA19720.1 - 8.5 6.2 14.4 4.1e+02 0.8 9.7 2.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding AIG1 PF04548.11 ESA19724.1 - 0.0052 15.9 0.1 0.012 14.7 0.0 1.4 1 1 0 1 1 1 1 AIG1 family Med15_fungi PF05397.7 ESA19724.1 - 0.033 14.1 0.6 0.12 12.3 0.1 2.0 2 0 0 2 2 2 0 Mediator complex subunit 15 EssA PF10661.4 ESA19724.1 - 0.065 12.9 0.3 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA DUF1262 PF06880.6 ESA19724.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1262) Leu_zip PF15294.1 ESA19725.1 - 0.007 15.5 0.4 0.013 14.6 0.3 1.4 1 0 0 1 1 1 1 Leucine zipper F-box-like PF12937.2 ESA19725.1 - 0.046 13.4 0.1 0.15 11.7 0.1 1.9 1 0 0 1 1 1 0 F-box-like LsmAD PF06741.8 ESA19727.1 - 1.2 9.2 4.9 0.28 11.3 0.3 2.2 2 0 0 2 2 2 0 LsmAD domain Retrotrans_gag PF03732.12 ESA19728.1 - 0.00085 19.3 0.0 0.00085 19.3 0.0 3.4 3 1 0 3 3 3 1 Retrotransposon gag protein Hrs_helical PF12210.3 ESA19729.1 - 0.018 15.2 0.3 0.42 10.9 0.1 2.4 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate FAR1 PF03101.10 ESA19729.1 - 0.2 12.1 4.3 0.57 10.7 3.0 1.7 1 0 0 1 1 1 0 FAR1 DNA-binding domain Cast PF10174.4 ESA19730.1 - 0.00015 20.0 9.9 0.00017 19.7 6.8 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone BBP1_C PF15272.1 ESA19730.1 - 0.0011 18.5 10.9 0.0013 18.2 7.6 1.1 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal Tropomyosin_1 PF12718.2 ESA19730.1 - 0.0019 18.0 11.6 0.0031 17.3 8.0 1.3 1 0 0 1 1 1 1 Tropomyosin like DUF3450 PF11932.3 ESA19730.1 - 0.0027 17.0 3.9 0.0037 16.5 2.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Fib_alpha PF08702.5 ESA19730.1 - 0.0029 17.7 0.2 0.0029 17.7 0.1 2.1 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family Pox_A_type_inc PF04508.7 ESA19730.1 - 0.0033 17.0 1.8 0.0033 17.0 1.2 3.8 5 0 0 5 5 3 1 Viral A-type inclusion protein repeat AAA_13 PF13166.1 ESA19730.1 - 0.0039 15.7 7.3 0.0044 15.5 5.1 1.1 1 0 0 1 1 1 1 AAA domain RE_SinI PF09570.5 ESA19730.1 - 0.0079 15.1 0.3 0.01 14.8 0.2 1.2 1 0 0 1 1 1 1 SinI restriction endonuclease Baculo_PEP_C PF04513.7 ESA19730.1 - 0.0092 15.8 0.3 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.3 ESA19730.1 - 0.031 14.0 2.7 0.031 14.0 1.8 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF148 PF02520.12 ESA19730.1 - 0.046 13.5 4.1 0.063 13.0 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF1669 PF07894.7 ESA19730.1 - 0.047 12.8 1.1 0.055 12.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1669) TSC22 PF01166.13 ESA19730.1 - 0.049 13.5 8.1 0.32 10.9 0.3 3.4 1 1 2 3 3 3 0 TSC-22/dip/bun family DUF16 PF01519.11 ESA19730.1 - 0.064 13.4 4.6 5.5 7.2 3.2 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 APG6 PF04111.7 ESA19730.1 - 0.08 11.9 10.3 0.091 11.7 7.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Macoilin PF09726.4 ESA19730.1 - 0.085 11.1 7.1 0.096 10.9 4.9 1.1 1 0 0 1 1 1 0 Transmembrane protein IncA PF04156.9 ESA19730.1 - 0.096 12.2 13.9 0.16 11.5 9.6 1.4 1 1 0 1 1 1 0 IncA protein Cluap1 PF10234.4 ESA19730.1 - 0.13 11.4 6.0 0.15 11.2 4.2 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF2968 PF11180.3 ESA19730.1 - 0.13 11.6 2.7 0.17 11.2 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Transposase_22 PF02994.9 ESA19730.1 - 0.14 10.6 6.6 0.17 10.3 4.6 1.1 1 0 0 1 1 1 0 L1 transposable element V_ATPase_I PF01496.14 ESA19730.1 - 0.16 9.7 6.2 0.16 9.8 3.7 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Phasin PF05597.6 ESA19730.1 - 0.19 11.4 3.3 0.57 9.9 2.3 1.9 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) SICA_alpha PF12887.2 ESA19730.1 - 0.23 11.1 4.0 0.38 10.4 2.5 1.6 1 1 1 2 2 2 0 SICA extracellular alpha domain DUF883 PF05957.8 ESA19730.1 - 0.24 11.8 3.4 0.36 11.2 0.2 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF724 PF05266.9 ESA19730.1 - 0.44 10.1 7.1 0.6 9.6 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.8 ESA19730.1 - 0.47 9.4 4.2 0.56 9.2 2.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF972 PF06156.8 ESA19730.1 - 0.49 10.7 6.9 0.7 10.2 3.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF972) XhlA PF10779.4 ESA19730.1 - 0.49 10.3 9.7 0.96 9.4 2.3 2.5 2 1 0 2 2 2 0 Haemolysin XhlA Seryl_tRNA_N PF02403.17 ESA19730.1 - 0.59 10.1 6.5 1.9 8.5 4.3 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain EAP30 PF04157.11 ESA19730.1 - 0.59 9.2 5.2 8 5.5 1.8 2.5 1 1 1 2 2 2 0 EAP30/Vps36 family LMBR1 PF04791.11 ESA19730.1 - 0.6 8.6 3.3 0.66 8.4 2.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_MLP1_2 PF07926.7 ESA19730.1 - 0.68 9.6 13.3 3.2 7.5 4.2 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 ESA19730.1 - 0.71 9.3 5.3 0.31 10.5 0.1 2.4 1 1 2 3 3 3 0 Septum formation initiator Tropomyosin PF00261.15 ESA19730.1 - 0.73 8.8 14.4 0.69 8.9 0.5 2.1 1 1 1 2 2 2 0 Tropomyosin DUF342 PF03961.8 ESA19730.1 - 0.87 7.9 6.3 1.1 7.5 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Muted PF14942.1 ESA19730.1 - 0.89 9.4 9.4 1 9.2 5.8 1.6 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Atg14 PF10186.4 ESA19730.1 - 1.1 8.0 10.5 1.4 7.7 7.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IFP_35_N PF07334.8 ESA19730.1 - 1.2 9.2 5.6 3.7 7.5 0.1 2.5 1 1 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus FKBP_N PF01346.13 ESA19730.1 - 1.5 8.8 4.4 1.6 8.7 0.6 2.1 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase V-SNARE PF05008.10 ESA19730.1 - 1.6 8.9 10.9 6.2 7.0 0.1 3.0 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF641 PF04859.7 ESA19730.1 - 1.7 8.4 6.4 1 9.0 1.2 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) UPF0184 PF03670.8 ESA19730.1 - 1.7 8.8 5.8 1.1 9.4 0.5 2.6 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) ADIP PF11559.3 ESA19730.1 - 2.6 7.9 14.2 1.8 8.4 7.9 1.9 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding FlxA PF14282.1 ESA19730.1 - 2.6 8.0 8.5 0.52 10.2 0.3 2.2 1 1 1 2 2 2 0 FlxA-like protein DNA_pol_B PF00136.16 ESA19731.1 - 8.1e-10 38.0 0.2 8.8e-10 37.9 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase family B EF-hand_6 PF13405.1 ESA19733.1 - 1.1e-22 77.7 1.5 4.5e-05 22.9 0.0 4.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.27 ESA19733.1 - 2.8e-22 76.2 3.5 3.3e-06 25.9 0.0 5.7 6 1 0 6 6 6 3 EF hand EF-hand_7 PF13499.1 ESA19733.1 - 9e-22 76.9 2.0 1.7e-09 37.6 0.3 3.4 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 ESA19733.1 - 1.6e-18 66.0 1.0 4.4e-08 32.6 0.0 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA19733.1 - 1.9e-15 55.4 4.5 3.7e-05 22.8 0.0 4.7 4 1 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 ESA19733.1 - 8.4e-06 25.6 0.1 0.71 9.8 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_4 PF12763.2 ESA19733.1 - 0.021 14.5 1.4 1.4 8.7 0.1 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF4493 PF14900.1 ESA19733.1 - 0.1 12.1 0.2 0.17 11.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) YjeF_N PF03853.10 ESA19734.1 - 2.8e-43 147.4 0.0 3.4e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF1235 PF06822.7 ESA19734.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) vATP-synt_E PF01991.13 ESA19735.1 - 9.5e-59 198.0 18.6 1.1e-58 197.7 12.9 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit PHD PF00628.24 ESA19736.1 - 4.5e-10 39.0 8.2 7.6e-10 38.3 5.7 1.4 1 0 0 1 1 1 1 PHD-finger Linker_histone PF00538.14 ESA19736.1 - 1.4e-06 28.3 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 linker histone H1 and H5 family PHD_2 PF13831.1 ESA19736.1 - 3.1e-05 23.2 3.6 7.4e-05 21.9 2.5 1.7 1 1 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.1 ESA19736.1 - 0.00045 19.8 5.7 0.00095 18.8 3.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 FYVE_2 PF02318.11 ESA19736.1 - 0.092 12.6 3.8 0.13 12.1 1.8 1.6 1 1 1 2 2 2 0 FYVE-type zinc finger zf-C4 PF00105.13 ESA19736.1 - 0.11 12.7 1.5 0.27 11.4 1.0 1.7 1 0 0 1 1 1 0 Zinc finger, C4 type (two domains) C1_1 PF00130.17 ESA19736.1 - 0.6 9.8 8.1 0.024 14.3 1.7 1.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Tnp_zf-ribbon_2 PF13842.1 ESA19736.1 - 0.73 10.2 8.6 0.52 10.7 3.7 2.2 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Tubulin PF00091.20 ESA19738.1 - 2.4e-11 43.9 0.0 2.4e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain CDP-OH_P_transf PF01066.16 ESA19740.1 - 5e-17 62.0 2.6 5e-17 62.0 1.8 2.6 2 2 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3816 PF12822.2 ESA19740.1 - 3.2e-05 23.8 5.2 3.2e-05 23.8 3.6 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF3816) Scramblase PF03803.10 ESA19744.1 - 0.012 14.6 0.6 0.014 14.4 0.4 1.1 1 0 0 1 1 1 0 Scramblase ResIII PF04851.10 ESA19746.1 - 0.002 17.9 0.1 0.0021 17.9 0.0 1.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESA19746.1 - 0.0034 17.1 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 ESA19746.1 - 0.0083 15.2 0.0 0.0094 15.0 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin T2SE PF00437.15 ESA19746.1 - 0.014 14.2 0.0 0.018 13.9 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 ESA19746.1 - 0.022 15.0 0.0 0.027 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESA19746.1 - 0.026 14.7 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA19746.1 - 0.054 14.3 0.0 0.066 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 ESA19746.1 - 0.082 12.1 0.3 0.13 11.5 0.2 1.3 1 1 0 1 1 1 0 PhoH-like protein RuvB_N PF05496.7 ESA19746.1 - 0.14 11.1 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus CTP_transf_1 PF01148.15 ESA19749.1 - 1.3e-09 38.1 12.3 1.3e-09 38.1 8.5 3.2 2 1 1 3 3 3 1 Cytidylyltransferase family D5_N PF08706.6 ESA19752.1 - 0.014 15.4 0.2 0.025 14.6 0.1 1.4 1 1 0 1 1 1 0 D5 N terminal like Maf PF02545.9 ESA19753.1 - 3.1e-56 189.6 0.0 3.7e-56 189.3 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DUF4604 PF15377.1 ESA19754.1 - 7.1e-16 58.8 23.0 1.2e-15 58.0 15.9 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) DUF4174 PF13778.1 ESA19754.1 - 0.093 12.8 1.0 0.13 12.3 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) COesterase PF00135.23 ESA19755.1 - 2.6e-16 59.4 0.3 1.4e-15 57.0 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_5 PF12695.2 ESA19755.1 - 5.1e-14 52.2 0.0 8.9e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 ESA19755.1 - 9.9e-12 44.8 0.0 1.3e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 ESA19755.1 - 3.2e-08 33.7 0.0 5.1e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESA19755.1 - 4.3e-06 26.0 0.0 0.0079 15.4 0.0 3.0 3 0 0 3 3 3 2 Prolyl oligopeptidase family Chlorophyllase2 PF12740.2 ESA19755.1 - 0.00032 19.6 0.0 0.00074 18.4 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 ESA19755.1 - 0.0078 15.0 0.1 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase FSH1 PF03959.8 ESA19755.1 - 0.019 14.4 0.0 0.051 13.0 0.0 1.5 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Lipase_3 PF01764.20 ESA19755.1 - 0.031 13.9 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.11 ESA19755.1 - 0.05 13.0 0.0 0.35 10.2 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF4451 PF14616.1 ESA19756.1 - 6.1e-29 100.3 10.1 1.2e-28 99.3 7.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4451) zf-RING_3 PF14369.1 ESA19756.1 - 0.06 13.3 0.1 0.24 11.4 0.1 2.0 1 0 0 1 1 1 0 zinc-finger DUF29 PF01724.11 ESA19758.1 - 0.023 14.5 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF29 DUF1401 PF07180.6 ESA19759.1 - 0.0055 16.4 0.1 3.4 7.4 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1401) O-FucT PF10250.4 ESA19760.1 - 8.2e-09 35.0 10.5 0.0019 17.4 3.0 3.2 1 1 1 2 2 2 2 GDP-fucose protein O-fucosyltransferase DUF3267 PF11667.3 ESA19760.1 - 0.0082 16.3 0.3 0.0082 16.3 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3267) Pex14_N PF04695.8 ESA19760.1 - 3.8 7.5 15.5 4 7.4 6.6 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Neur_chan_memb PF02932.11 ESA19760.1 - 3.9 7.2 10.0 4 7.2 5.1 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region P4Ha_N PF08336.6 ESA19761.1 - 0.088 12.6 0.0 0.088 12.6 0.0 1.1 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2669 PF10876.3 ESA19762.1 - 0.11 12.2 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2669) 5-FTHF_cyc-lig PF01812.15 ESA19763.1 - 2.3e-32 112.2 0.2 3.8e-30 105.0 0.1 2.0 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Vezatin PF12632.2 ESA19764.1 - 4.5e-34 117.6 3.9 1e-33 116.4 2.7 1.6 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes HATPase_c_4 PF13749.1 ESA19764.1 - 0.025 14.3 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 ATP-dependent DNA helicase recG C-terminal DUF4229 PF14012.1 ESA19764.1 - 0.071 13.0 1.1 0.13 12.1 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) DUF2637 PF10935.3 ESA19764.1 - 0.13 12.2 0.2 0.21 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) JAB PF01398.16 ESA19765.1 - 1.9e-35 121.0 0.0 3.6e-35 120.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 ESA19765.1 - 4.9e-29 100.7 4.3 2.3e-28 98.5 3.2 2.0 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 ESA19765.1 - 6.9e-08 32.0 0.0 1.1e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain NAD_binding_8 PF13450.1 ESA19767.1 - 4.6e-10 39.3 0.1 6.4e-10 38.9 0.1 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 ESA19767.1 - 0.00019 20.6 0.0 0.00021 20.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 ESA19767.1 - 0.0023 16.8 0.2 0.0024 16.8 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 ESA19767.1 - 0.019 14.7 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.12 ESA19767.1 - 0.023 13.7 0.1 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 ESA19767.1 - 0.11 12.2 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Prenylcys_lyase PF07156.9 ESA19768.1 - 4.7e-22 78.3 0.0 5.7e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.19 ESA19768.1 - 0.011 14.8 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase YhdB PF14148.1 ESA19768.1 - 0.094 12.4 0.1 0.18 11.5 0.1 1.6 1 1 0 1 1 1 0 YhdB-like protein TAP_C PF03943.8 ESA19769.1 - 0.01 15.2 0.2 0.026 13.9 0.1 1.7 1 0 0 1 1 1 0 TAP C-terminal domain zf-CCCH PF00642.19 ESA19769.1 - 0.1 12.3 0.4 0.17 11.5 0.3 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Cap_synth_GfcB PF11102.3 ESA19770.1 - 0.043 13.3 0.2 0.1 12.1 0.0 1.6 2 0 0 2 2 2 0 Group 4 capsule polysaccharide formation lipoprotein gfcB p450 PF00067.17 ESA19771.1 - 4.4e-38 130.9 0.1 5.7e-38 130.6 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Terpene_synth_C PF03936.11 ESA19771.1 - 0.044 13.0 0.1 0.12 11.5 0.0 1.7 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain p450 PF00067.17 ESA19772.1 - 0.033 12.7 0.1 0.038 12.4 0.0 1.0 1 0 0 1 1 1 0 Cytochrome P450 FecCD PF01032.13 ESA19775.1 - 0.28 9.9 0.9 0.44 9.3 0.6 1.2 1 0 0 1 1 1 0 FecCD transport family Sugar_tr PF00083.19 ESA19776.1 - 1.1e-103 347.2 38.6 3.8e-78 263.0 14.4 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 ESA19776.1 - 1.1e-31 109.8 25.9 1.1e-31 109.8 17.9 2.3 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 ESA19776.1 - 1.1e-05 23.8 7.7 1.1e-05 23.8 5.3 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DNA_pol_B_exo1 PF03104.14 ESA19781.1 - 2.4e-16 59.4 1.3 3.3e-16 59.0 0.9 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Methyltransf_11 PF08241.7 ESA19782.1 - 2.4e-14 53.5 0.0 1.8e-13 50.7 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA19782.1 - 9.1e-14 51.3 0.2 8e-13 48.2 0.1 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA19782.1 - 5.9e-12 45.6 0.0 1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA19782.1 - 1.7e-11 44.3 0.0 3.8e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA19782.1 - 1.2e-08 34.3 0.0 4.4e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA19782.1 - 5.7e-08 33.3 0.0 9.3e-07 29.4 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA19782.1 - 3.5e-06 27.4 0.0 1.4e-05 25.4 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA19782.1 - 3.7e-05 23.4 0.0 9.1e-05 22.1 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_4 PF02390.12 ESA19782.1 - 0.0012 17.9 0.0 0.0045 16.0 0.0 1.9 2 1 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA19782.1 - 0.0024 17.8 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA19782.1 - 0.0097 15.9 0.0 0.012 15.6 0.0 1.3 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_29 PF03141.11 ESA19782.1 - 0.016 13.5 0.4 0.098 10.9 0.1 2.2 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 ESA19782.1 - 0.03 13.7 0.0 0.066 12.5 0.0 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW DUF1963 PF09234.5 ESA19782.1 - 0.034 14.3 0.1 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) Methyltransf_11 PF08241.7 ESA19783.1 - 3.1e-13 50.0 0.0 2.5e-11 43.8 0.0 3.0 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA19783.1 - 2.6e-11 43.3 1.3 9.3e-10 38.2 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA19783.1 - 3e-11 43.3 0.0 7.5e-11 42.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA19783.1 - 8.2e-09 35.7 0.0 3.2e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA19783.1 - 8.4e-08 31.6 0.0 2.6e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA19783.1 - 8.1e-07 29.6 0.0 1.7e-05 25.3 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA19783.1 - 6.2e-06 26.6 0.0 7.5e-05 23.1 0.0 2.8 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.10 ESA19783.1 - 0.00098 18.8 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_4 PF02390.12 ESA19783.1 - 0.0014 17.7 0.0 0.0045 16.0 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.14 ESA19783.1 - 0.0029 17.6 0.0 0.0045 17.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 ESA19783.1 - 0.05 12.9 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_26 PF13659.1 ESA19783.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Yae1_N PF09811.4 ESA19784.1 - 0.13 11.8 1.4 0.19 11.2 1.0 1.3 1 0 0 1 1 1 0 Essential protein Yae1, N terminal ICL PF00463.16 ESA19785.1 - 8.1e-261 865.7 0.9 9.2e-261 865.5 0.6 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 ESA19785.1 - 1.7e-08 34.0 0.0 3.5e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase PRP38 PF03371.10 ESA19787.1 - 4.1e-47 159.9 0.1 5e-47 159.7 0.1 1.0 1 0 0 1 1 1 1 PRP38 family ACOX PF01756.14 ESA19787.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA oxidase Sec1 PF00995.18 ESA19788.1 - 2.1e-167 558.2 7.4 2.4e-167 557.9 5.1 1.0 1 0 0 1 1 1 1 Sec1 family RdRP PF05183.7 ESA19789.1 - 2.1e-192 640.8 1.7 3.3e-192 640.2 1.2 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase p450 PF00067.17 ESA19790.1 - 1e-50 172.6 0.0 1.3e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Syntaxin-18_N PF10496.4 ESA19790.1 - 0.17 11.7 0.4 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus p450 PF00067.17 ESA19792.1 - 2e-48 165.0 0.0 2.6e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 N1221 PF07923.8 ESA19793.1 - 2.6e-57 193.9 0.2 7.6e-56 189.0 0.0 2.1 2 0 0 2 2 2 2 N1221-like protein DUF3402 PF11882.3 ESA19793.1 - 0.0039 16.3 0.4 0.0039 16.3 0.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3402) zf-AN1 PF01428.11 ESA19794.1 - 1.2e-21 76.2 28.2 1.2e-11 44.2 5.0 2.5 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.10 ESA19794.1 - 5.2 7.3 14.6 6 7.1 3.3 2.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain HAUS6_N PF14661.1 ESA19795.1 - 9.6e-36 123.3 1.5 2e-35 122.3 0.3 1.9 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus Rootletin PF15035.1 ESA19795.1 - 0.0097 15.8 0.6 0.0097 15.8 0.4 1.9 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion CHASE3 PF05227.8 ESA19795.1 - 0.058 13.0 1.2 0.1 12.2 0.1 1.8 2 0 0 2 2 2 0 CHASE3 domain Sld5 PF05916.6 ESA19795.1 - 0.19 12.0 4.6 1.6 9.0 0.2 3.2 3 0 0 3 3 3 0 GINS complex protein DUF2746 PF10874.3 ESA19795.1 - 0.38 10.9 2.7 0.38 10.9 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2746) IncA PF04156.9 ESA19795.1 - 2.7 7.5 10.2 0.33 10.5 0.9 2.3 2 0 0 2 2 2 0 IncA protein Rpp20 PF12328.3 ESA19796.1 - 1.9e-10 40.5 8.2 5.6e-08 32.5 0.0 3.3 2 2 1 3 3 3 2 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 ESA19796.1 - 2.1e-10 40.0 0.0 5.3e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Alba Choline_kinase PF01633.15 ESA19796.1 - 0.037 13.5 0.4 0.058 12.9 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Sec62 PF03839.11 ESA19796.1 - 2.4 7.4 6.1 5.2 6.4 4.2 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 SWIB PF02201.13 ESA19797.1 - 2.1e-27 94.5 0.4 4.3e-27 93.6 0.2 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.6 ESA19797.1 - 5.4e-12 45.3 0.5 1.2e-11 44.2 0.4 1.5 1 0 0 1 1 1 1 DEK C terminal domain Ndc1_Nup PF09531.5 ESA19797.1 - 8.1 4.7 12.2 11 4.3 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Gp_dh_C PF02800.15 ESA19798.1 - 3e-70 234.7 0.0 4.5e-70 234.1 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 ESA19798.1 - 5.5e-53 178.9 0.0 9e-53 178.2 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA PF03968.9 ESA19798.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 OstA-like protein H2TH PF06831.9 ESA19799.1 - 8.9e-26 89.4 0.0 1.5e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.19 ESA19799.1 - 5.4e-24 84.7 0.0 8.4e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain FbpA PF05833.6 ESA19799.1 - 0.00075 18.1 0.0 0.001 17.7 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) RF-1 PF00472.15 ESA19800.1 - 2.5e-23 82.0 1.1 4.2e-23 81.3 0.8 1.4 1 0 0 1 1 1 1 RF-1 domain Mago_nashi PF02792.9 ESA19800.1 - 0.016 14.8 0.2 0.02 14.6 0.2 1.2 1 0 0 1 1 1 0 Mago nashi protein Ribosomal_S8e PF01201.17 ESA19801.1 - 1.4e-32 112.5 0.9 2.8e-32 111.6 0.6 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e DUF3959 PF13105.1 ESA19801.1 - 2.6 7.3 13.2 0.24 10.7 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3959) Cohesin_load PF10345.4 ESA19802.1 - 4e-59 200.4 27.8 8e-59 199.4 19.3 1.4 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.1 ESA19802.1 - 0.00014 21.7 9.7 1.2 9.1 0.1 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat RPN7 PF10602.4 ESA19802.1 - 0.058 12.7 5.0 0.27 10.5 0.0 3.6 3 2 1 4 4 4 0 26S proteasome subunit RPN7 BTB PF00651.26 ESA19803.1 - 5.1e-14 52.1 0.1 1.1e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA19803.1 - 6.9e-13 48.7 0.0 1.4e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 SPRY domain SE PF08491.5 ESA19804.1 - 1.2e-103 345.6 0.0 1.5e-103 345.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 ESA19804.1 - 0.00016 20.8 0.0 0.0032 16.5 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 ESA19804.1 - 0.024 13.4 0.3 4.8 5.9 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_8 PF13450.1 ESA19804.1 - 0.028 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 ESA19804.1 - 0.094 11.5 0.0 1.6 7.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain DUF1088 PF06469.6 ESA19805.1 - 0.024 14.0 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1088) Proteasom_PSMB PF10508.4 ESA19807.1 - 1.8e-69 234.3 4.7 2e-69 234.1 3.3 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit RTTN_N PF14726.1 ESA19807.1 - 0.00015 22.2 0.0 0.033 14.7 0.0 3.5 3 1 1 5 5 5 1 Rotatin, an armadillo repeat protein, centriole functioning HEAT_2 PF13646.1 ESA19807.1 - 0.0015 18.7 0.0 0.013 15.7 0.0 2.6 3 0 0 3 3 3 1 HEAT repeats V-ATPase_H_C PF11698.3 ESA19807.1 - 0.0078 16.1 0.4 1.4 8.8 0.0 3.8 3 1 2 5 5 5 1 V-ATPase subunit H DUF3944 PF13099.1 ESA19807.1 - 0.11 11.9 0.2 0.31 10.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) Robl_LC7 PF03259.12 ESA19808.1 - 5.8e-15 54.6 0.1 9.7e-15 53.9 0.0 1.3 2 0 0 2 2 2 1 Roadblock/LC7 domain HMGL-like PF00682.14 ESA19809.1 - 5.9e-72 242.1 0.1 9.3e-72 241.5 0.1 1.3 1 0 0 1 1 1 1 HMGL-like KOW PF00467.24 ESA19810.1 - 5.4e-09 35.4 1.7 5.4e-09 35.4 1.2 2.8 3 1 1 4 4 4 1 KOW motif ssDNA-exonuc_C PF10141.4 ESA19812.1 - 0.036 13.5 0.0 0.036 13.5 0.0 1.0 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain DDE_1 PF03184.14 ESA19813.1 - 2.8e-56 190.0 0.0 3.8e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA19813.1 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA19813.1 - 0.016 14.9 0.7 0.03 14.1 0.1 1.8 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain Ank PF00023.25 ESA19814.1 - 6.4e-07 28.8 1.8 0.062 13.1 0.0 4.6 3 1 2 5 5 5 3 Ankyrin repeat Ank_2 PF12796.2 ESA19814.1 - 6.8e-06 26.3 1.1 0.014 15.6 0.1 3.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA19814.1 - 0.00011 22.0 0.9 0.25 11.7 0.0 3.9 2 2 1 3 3 3 1 Ankyrin repeat Nudix_N PF12535.3 ESA19814.1 - 0.15 11.5 0.6 0.29 10.6 0.4 1.4 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal UPRTase PF14681.1 ESA19815.1 - 8.4e-82 273.3 0.0 1.1e-81 273.0 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 ESA19815.1 - 1.7e-06 27.7 0.0 3.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 ESA19815.1 - 0.08 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) PEMT PF04191.8 ESA19816.1 - 1.2e-53 179.6 14.7 2.2e-32 111.3 1.9 3.3 3 0 0 3 3 3 2 Phospholipid methyltransferase RVT_N PF13655.1 ESA19816.1 - 0.0029 17.6 0.4 0.31 11.1 0.0 2.6 2 0 0 2 2 2 1 N-terminal domain of reverse transcriptase DUF883 PF05957.8 ESA19816.1 - 0.18 12.2 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Macro PF01661.16 ESA19817.1 - 1.3e-32 112.2 0.3 9.6e-32 109.3 0.0 2.5 2 0 0 2 2 2 1 Macro domain ING PF12998.2 ESA19820.1 - 1.8e-15 57.0 9.0 1.6e-13 50.8 6.3 2.4 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 ESA19820.1 - 5.4e-09 35.6 7.4 9.1e-09 34.8 5.1 1.4 1 0 0 1 1 1 1 PHD-finger BicD PF09730.4 ESA19820.1 - 0.0025 16.2 1.4 0.0033 15.8 1.0 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D PHD_2 PF13831.1 ESA19820.1 - 0.034 13.4 4.6 0.066 12.5 3.2 1.5 1 0 0 1 1 1 0 PHD-finger Strep_67kDa_ant PF06100.6 ESA19820.1 - 0.55 8.5 6.7 0.034 12.5 1.0 1.6 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family NGP1NT PF08153.7 ESA19821.1 - 2.6e-51 172.9 0.4 4.5e-51 172.1 0.1 1.6 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 ESA19821.1 - 3.3e-20 72.1 0.1 1e-14 54.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA19821.1 - 1.2e-05 24.6 0.1 0.0001 21.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 ESA19821.1 - 2.5e-05 23.7 0.7 0.0061 16.0 0.0 3.4 4 0 0 4 4 4 1 Elongation factor Tu GTP binding domain Arf PF00025.16 ESA19821.1 - 0.00022 20.5 0.3 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF258 PF03193.11 ESA19821.1 - 0.00034 19.8 0.0 0.00071 18.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SusD-like_3 PF14322.1 ESA19821.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Starch-binding associating with outer membrane CENP-F_leu_zip PF10473.4 ESA19821.1 - 0.53 10.1 8.9 5.2 6.9 1.3 3.2 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Dynamin_N PF00350.18 ESA19821.1 - 0.55 10.0 9.8 0.58 9.9 0.0 4.1 4 2 1 5 5 5 0 Dynamin family p450 PF00067.17 ESA19823.1 - 9.8e-30 103.4 0.0 1.2e-29 103.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TauE PF01925.14 ESA19824.1 - 0.0072 15.8 7.8 0.016 14.6 5.4 1.6 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Bax1-I PF01027.15 ESA19824.1 - 0.26 10.8 10.8 0.032 13.8 4.1 1.9 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 PRA1 PF03208.14 ESA19824.1 - 3.8 6.8 6.7 2.7 7.3 2.6 2.2 2 0 0 2 2 2 0 PRA1 family protein Abi PF02517.11 ESA19824.1 - 5.8 7.1 9.3 15 5.8 6.4 2.2 1 1 0 1 1 1 0 CAAX protease self-immunity DUF4293 PF14126.1 ESA19824.1 - 6.4 6.6 9.0 1.2 9.0 1.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4293) HMG_box PF00505.14 ESA19825.1 - 3.4e-07 30.4 0.0 5.1e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box F-box-like PF12937.2 ESA19826.1 - 0.00053 19.6 3.8 0.00058 19.5 0.2 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 ESA19826.1 - 0.34 10.6 2.8 10 5.8 0.1 3.2 3 0 0 3 3 3 0 F-box domain Apis_Csd PF11671.3 ESA19827.1 - 0.22 11.3 11.3 0.28 10.9 7.8 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein FAR1 PF03101.10 ESA19828.1 - 3.2e-08 33.9 0.4 4.5e-08 33.5 0.3 1.2 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA19828.1 - 1.1e-05 24.8 0.0 0.012 15.1 0.0 2.3 2 0 0 2 2 2 2 MuDR family transposase Pkinase_Tyr PF07714.12 ESA19829.1 - 9.2e-35 119.9 0.0 1.2e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19829.1 - 2.7e-34 118.5 1.2 5e-34 117.6 0.8 1.4 1 1 0 1 1 1 1 Protein kinase domain Menin PF05053.8 ESA19830.1 - 0.33 9.0 1.6 0.35 8.9 1.1 1.0 1 0 0 1 1 1 0 Menin Lipase_3 PF01764.20 ESA19831.1 - 0.072 12.7 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) zf-RING_3 PF14369.1 ESA19833.1 - 0.083 12.8 0.6 11 6.0 0.0 2.6 2 0 0 2 2 2 0 zinc-finger ADK_lid PF05191.9 ESA19833.1 - 0.61 9.8 4.2 2.8 7.6 0.2 2.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid 2-Hacid_dh_C PF02826.14 ESA19834.1 - 7.4e-30 103.4 0.0 1e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Myb_DNA-bind_6 PF13921.1 ESA19835.1 - 0.002 18.1 6.2 0.0028 17.7 0.1 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA19836.1 - 0.00022 21.2 3.0 0.00085 19.3 0.5 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Sel1 PF08238.7 ESA19837.1 - 1.3e-70 232.2 20.0 4e-12 46.3 0.2 9.4 8 1 1 9 9 9 9 Sel1 repeat Pkinase_Tyr PF07714.12 ESA19837.1 - 4.9e-43 147.0 0.0 7.2e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19837.1 - 6e-41 140.3 0.3 1.1e-40 139.4 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA19837.1 - 0.0001 21.6 2.2 0.00018 20.8 0.6 2.1 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA19837.1 - 0.00018 20.6 0.0 0.00031 19.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA19837.1 - 0.00047 19.9 0.5 0.0012 18.5 0.5 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family TPR_11 PF13414.1 ESA19837.1 - 0.0029 17.1 21.4 0.86 9.2 0.5 6.7 3 1 4 7 7 7 3 TPR repeat Kdo PF06293.9 ESA19837.1 - 0.0048 15.9 0.0 0.0083 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_6 PF13174.1 ESA19837.1 - 0.017 15.5 12.7 25 5.5 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat MIT PF04212.13 ESA19837.1 - 0.046 13.5 21.9 1.2 9.0 0.0 6.9 5 3 0 5 5 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA19838.1 - 6.5e-41 137.8 9.1 1.3e-09 38.4 0.2 4.8 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA19838.1 - 0.0064 16.8 1.4 16 6.1 0.0 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat AdoMet_MTase PF07757.8 ESA19838.1 - 0.01 15.9 0.5 7.2 6.7 0.0 3.3 2 1 1 3 3 3 0 Predicted AdoMet-dependent methyltransferase NSF PF02071.15 ESA19838.1 - 0.12 13.0 2.5 18 6.4 0.1 4.0 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.13 ESA19838.1 - 0.5 10.2 10.4 4.2 7.3 1.1 4.0 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain Pkinase PF00069.20 ESA19839.1 - 6e-39 133.7 0.3 1.2e-38 132.7 0.2 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19839.1 - 2.2e-38 131.8 0.0 2.7e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA19839.1 - 0.035 13.8 0.1 0.065 12.9 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family hGDE_N PF14699.1 ESA19839.1 - 0.06 13.1 3.9 0.35 10.7 2.6 2.1 1 1 0 1 1 1 0 N-terminal domain from the human glycogen debranching enzyme RmlD_sub_bind PF04321.12 ESA19840.1 - 5e-51 173.2 0.0 5.7e-51 173.0 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 ESA19840.1 - 4.7e-23 81.8 0.0 5.8e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 ESA19840.1 - 4e-12 45.5 0.0 4.1e-09 35.7 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 ESA19840.1 - 1.1e-11 44.1 0.6 1.2e-09 37.4 0.4 2.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 ESA19840.1 - 1e-07 32.1 0.0 1.3e-07 31.8 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA19840.1 - 4.4e-06 25.6 0.0 1.3e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 ESA19840.1 - 0.00054 19.8 0.1 0.00098 19.0 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.20 ESA19840.1 - 0.00083 19.3 1.2 0.042 13.7 0.8 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA19840.1 - 0.05 13.3 0.4 0.88 9.2 0.1 2.1 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_3 PF03447.11 ESA19840.1 - 0.11 12.8 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain KR PF08659.5 ESA19840.1 - 0.18 11.4 1.1 1.7 8.2 0.0 2.3 2 1 1 3 3 3 0 KR domain Pkinase_Tyr PF07714.12 ESA19842.1 - 4.4e-51 173.4 0.0 7.6e-51 172.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA19842.1 - 6.6e-44 150.0 0.8 2e-43 148.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA19843.1 - 1.6e-77 254.2 42.5 4.2e-12 46.2 0.6 8.0 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA19843.1 - 3.9e-05 23.8 17.1 3.7 8.2 0.0 6.6 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA19843.1 - 4.1e-05 23.4 19.5 11 6.5 0.1 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA19843.1 - 0.00019 21.0 14.0 3.4 7.4 0.0 6.8 7 0 0 7 7 7 2 Lung surfactant protein D coiled-coil trimerisation MIT PF04212.13 ESA19843.1 - 0.0006 19.6 28.1 1.7 8.5 0.3 7.2 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain DCP1 PF06058.8 ESA19843.1 - 0.0081 16.1 15.5 3.2 7.8 0.2 5.1 1 1 3 5 5 5 3 Dcp1-like decapping family TOM20_plant PF06552.7 ESA19843.1 - 0.99 8.9 9.6 2.5 7.6 0.2 4.0 3 2 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 NDT80_PhoG PF05224.7 ESA19845.1 - 9.7e-39 133.2 0.0 2.6e-38 131.9 0.0 1.7 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family TLD PF07534.11 ESA19848.1 - 2.7e-12 46.8 2.0 4.5e-12 46.1 1.4 1.4 1 0 0 1 1 1 1 TLD RNA_pol_Rpb1_3 PF04983.13 ESA19848.1 - 0.052 13.2 0.2 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 3 DUF1474 PF07342.6 ESA19848.1 - 0.056 13.6 2.0 0.19 11.9 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) Cnd3 PF12719.2 ESA19848.1 - 0.084 11.8 0.1 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain TMEM191C PF15194.1 ESA19849.1 - 0.059 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 TMEM191C family Pkinase_Tyr PF07714.12 ESA19851.1 - 0.077 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase TLD PF07534.11 ESA19852.1 - 1.8e-09 37.7 0.4 3.2e-09 36.9 0.3 1.5 1 0 0 1 1 1 1 TLD Myb_DNA-bind_6 PF13921.1 ESA19855.1 - 0.0023 17.9 0.0 0.0025 17.8 0.0 1.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA19855.1 - 0.086 12.9 0.0 0.095 12.7 0.0 1.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF733 PF05306.6 ESA19856.1 - 7.1 6.9 12.0 0.13 12.5 3.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF733) CENP-H PF05837.7 ESA19857.1 - 0.0089 16.1 0.7 0.014 15.5 0.5 1.2 1 0 0 1 1 1 1 Centromere protein H (CENP-H) Imm9 PF15561.1 ESA19857.1 - 0.048 13.2 2.2 0.094 12.3 1.4 1.7 1 1 0 1 1 1 0 Immunity protein 9 DUF2874 PF11396.3 ESA19858.1 - 0.07 13.1 0.3 0.073 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2874) DUF4218 PF13960.1 ESA19859.1 - 0.00073 18.9 0.2 0.00095 18.6 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4218) zf-CCHC_4 PF14392.1 ESA19859.1 - 0.039 13.6 0.1 0.075 12.7 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle AICARFT_IMPCHas PF01808.13 ESA19861.1 - 1.6e-115 385.5 0.0 2.1e-115 385.1 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 ESA19861.1 - 9e-25 86.4 0.1 1.9e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain DUF2316 PF10078.4 ESA19861.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) DEAD PF00270.24 ESA19862.1 - 8.5e-39 132.7 0.2 2.6e-37 127.8 0.1 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA19862.1 - 1.3e-21 76.1 0.1 3.8e-21 74.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA19862.1 - 5.2e-12 45.9 0.0 5.2e-12 45.9 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESA19862.1 - 0.00098 18.0 0.0 0.0026 16.6 0.0 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 ESA19862.1 - 0.0048 17.0 0.3 0.73 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA19862.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Flavi_DEAD PF07652.9 ESA19862.1 - 0.075 12.7 0.1 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain PEPcase_2 PF14010.1 ESA19863.1 - 0.085 11.1 0.3 0.1 10.9 0.2 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase RabGAP-TBC PF00566.13 ESA19864.1 - 2.1e-36 125.4 1.3 2.1e-36 125.4 0.9 1.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rhomboid PF01694.17 ESA19865.1 - 2.1e-35 121.9 14.6 3.6e-35 121.1 10.1 1.4 1 0 0 1 1 1 1 Rhomboid family DUF1426 PF07234.6 ESA19865.1 - 0.17 11.6 0.5 16 5.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1426) NUMOD4 PF07463.6 ESA19866.1 - 6.1e-05 22.8 0.5 0.00016 21.5 0.3 1.8 1 0 0 1 1 1 1 NUMOD4 motif CobT PF06213.7 ESA19866.1 - 0.94 8.5 7.6 1.6 7.7 5.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_ner PF04546.8 ESA19866.1 - 0.97 9.0 7.0 0.39 10.3 3.0 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region Upf2 PF04050.9 ESA19866.1 - 4.9 6.8 9.0 11 5.7 6.3 1.5 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Nucleoplasmin PF03066.10 ESA19866.1 - 6.1 6.3 11.3 14 5.1 7.8 1.6 1 0 0 1 1 1 0 Nucleoplasmin CDC45 PF02724.9 ESA19866.1 - 7.9 4.3 10.3 0.9 7.4 4.2 1.5 1 1 0 1 1 1 0 CDC45-like protein YqzH PF14164.1 ESA19867.1 - 0.036 13.9 0.6 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 YqzH-like protein PPV_E2_N PF00508.12 ESA19871.1 - 0.065 12.4 0.5 0.07 12.3 0.4 1.0 1 0 0 1 1 1 0 E2 (early) protein, N terminal Ribosomal_L37 PF08561.5 ESA19871.1 - 0.17 11.4 1.1 0.18 11.3 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 BTB PF00651.26 ESA19873.1 - 7.8e-19 67.7 0.1 9.1e-19 67.4 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Dimer_Tnp_hAT PF05699.9 ESA19874.1 - 2.1e-08 33.6 0.3 2.4e-08 33.4 0.2 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region JTB PF05439.7 ESA19874.1 - 0.055 13.2 0.0 0.06 13.1 0.0 1.0 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Sulfolobus_pRN PF05584.6 ESA19874.1 - 0.12 12.3 0.2 0.18 11.7 0.1 1.4 1 1 1 2 2 2 0 Sulfolobus plasmid regulatory protein DDE_1 PF03184.14 ESA19876.1 - 5.8e-13 48.4 0.0 7e-13 48.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Radial_spoke_3 PF06098.6 ESA19876.1 - 0.074 12.0 0.1 0.096 11.6 0.0 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 KdpD PF02702.12 ESA19877.1 - 0.046 12.8 0.1 0.13 11.3 0.0 1.6 1 1 1 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain NMT_C PF02799.10 ESA19878.1 - 0.0039 16.5 0.3 0.0041 16.5 0.2 1.1 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Sec62 PF03839.11 ESA19878.1 - 0.21 10.9 5.9 0.23 10.8 4.1 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 zf-RanBP PF00641.13 ESA19880.1 - 1.7e-17 62.1 11.4 4.1e-09 35.3 1.9 2.1 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-C3HC4_3 PF13920.1 ESA19880.1 - 0.0037 16.9 6.7 0.22 11.1 0.5 2.1 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) DZR PF12773.2 ESA19880.1 - 0.012 15.4 11.9 0.14 12.0 1.5 2.1 1 1 1 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 ESA19880.1 - 0.052 13.3 3.4 0.052 13.3 2.4 2.8 1 1 2 3 3 3 0 Transposase zinc-ribbon domain Prim_Zn_Ribbon PF08273.7 ESA19880.1 - 0.059 13.4 2.4 0.059 13.4 1.7 3.3 2 1 1 3 3 3 0 Zinc-binding domain of primase-helicase PHD PF00628.24 ESA19880.1 - 0.25 11.0 11.0 0.27 10.9 1.4 2.9 3 0 0 3 3 3 0 PHD-finger PHD_2 PF13831.1 ESA19880.1 - 0.31 10.3 0.3 0.31 10.3 0.2 3.6 4 0 0 4 4 4 0 PHD-finger HCV_NS1 PF01560.12 ESA19880.1 - 0.64 8.4 3.4 0.7 8.2 2.3 1.1 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 PhnA_Zn_Ribbon PF08274.7 ESA19880.1 - 0.86 9.4 9.6 0.24 11.2 0.3 2.8 3 1 0 3 3 3 0 PhnA Zinc-Ribbon NCD3G PF07562.9 ESA19880.1 - 2.7 7.7 14.4 4.4 7.1 2.0 2.3 1 1 1 2 2 2 0 Nine Cysteines Domain of family 3 GPCR ArfGap PF01412.13 ESA19880.1 - 4.9 6.9 10.9 0.58 9.9 0.9 2.8 1 1 2 3 3 3 0 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.7 ESA19880.1 - 5.7 6.3 13.5 0.59 9.4 0.5 2.8 3 0 0 3 3 3 0 TFIIB zinc-binding DUF1201 PF06716.6 ESA19882.1 - 0.95 9.3 5.1 1.4 8.7 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) HD PF01966.17 ESA19883.1 - 1.1e-14 54.5 0.4 3.9e-14 52.7 0.0 2.1 2 0 0 2 2 2 1 HD domain USP7_ICP0_bdg PF12436.3 ESA19884.1 - 2.7e-85 285.5 4.0 3.3e-84 282.0 0.3 3.1 3 1 1 4 4 4 2 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA19884.1 - 1.1e-64 217.7 13.5 2.4e-64 216.6 3.2 3.4 3 1 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.24 ESA19884.1 - 1.1e-58 198.4 1.7 1.8e-58 197.7 1.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA19884.1 - 4.3e-34 118.3 0.0 8.5e-34 117.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WW PF00397.21 ESA19885.1 - 1.2e-05 25.0 5.1 1.2e-05 25.0 3.5 2.9 2 0 0 2 2 2 1 WW domain Mito_fiss_reg PF05308.6 ESA19885.1 - 3.5 6.9 12.7 0.058 12.7 1.2 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator USP7_ICP0_bdg PF12436.3 ESA19886.1 - 2.5e-66 223.4 2.3 7.2e-66 221.9 0.2 2.4 3 0 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 ESA19886.1 - 6.7e-62 208.6 11.5 2.4e-60 203.6 4.2 2.2 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal RGS PF00615.14 ESA19888.1 - 8.9e-31 106.4 2.2 2.5e-30 104.9 0.0 2.6 3 1 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.16 ESA19888.1 - 3.7e-19 68.2 0.4 4.5e-12 45.5 0.0 3.3 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF573 PF04504.9 ESA19888.1 - 0.02 15.1 1.6 4.4 7.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function, DUF573 DUF4459 PF14673.1 ESA19889.1 - 0.032 13.9 0.1 2.9 7.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4459) PPI_Ypi1 PF07491.6 ESA19889.1 - 0.094 12.3 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein phosphatase inhibitor Aa_trans PF01490.13 ESA19890.1 - 2.1e-67 227.4 33.8 2.6e-67 227.1 23.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ERGIC_N PF13850.1 ESA19890.1 - 0.0095 15.8 0.1 0.0095 15.8 0.1 4.7 5 1 1 6 6 6 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PRP1_N PF06424.7 ESA19891.1 - 2.5e-53 179.9 5.7 4.8e-53 179.0 4.0 1.5 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 ESA19891.1 - 1.6e-14 53.1 3.9 0.0033 17.9 0.1 6.3 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA19891.1 - 6.9e-08 32.7 2.1 0.34 11.2 0.0 5.3 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA19891.1 - 3e-05 24.5 2.3 0.16 12.6 0.0 4.4 2 1 3 5 5 5 1 Tetratricopeptide repeat Suf PF05843.9 ESA19891.1 - 0.043 13.5 0.6 2 8.0 0.0 3.0 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) TPR_8 PF13181.1 ESA19891.1 - 0.087 12.6 0.7 11 6.0 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat FNIP PF05725.7 ESA19892.1 - 9.1 6.3 9.5 3 7.8 0.3 3.5 3 1 0 3 3 3 0 FNIP Repeat USP7_C2 PF14533.1 ESA19893.1 - 2.5e-24 85.8 1.0 3.6e-22 78.8 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin-specific protease C-terminal CHB_HEX PF03173.8 ESA19894.1 - 0.00066 19.1 0.0 0.0016 17.9 0.0 1.5 1 1 1 2 2 2 1 Putative carbohydrate binding domain F-box-like PF12937.2 ESA19896.1 - 1.8e-07 30.7 1.6 3.9e-07 29.6 0.9 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA19896.1 - 2.5e-07 30.1 1.3 2.5e-07 30.1 0.9 2.5 3 0 0 3 3 3 1 F-box domain zf-HYPF PF07503.7 ESA19896.1 - 0.099 12.0 4.8 0.18 11.2 3.3 1.4 1 0 0 1 1 1 0 HypF finger FYRC PF05965.9 ESA19897.1 - 0.025 14.3 0.2 0.33 10.7 0.0 2.8 2 1 0 2 2 2 0 F/Y rich C-terminus Chordopox_L2 PF05803.7 ESA19897.1 - 7.5 6.2 10.9 0.13 11.8 1.7 2.3 2 1 0 2 2 2 0 Chordopoxvirus L2 protein CENP-I PF07778.6 ESA19898.1 - 4.2e-83 279.2 13.9 6.2e-83 278.7 9.6 1.2 1 0 0 1 1 1 1 Mis6 CHCH PF06747.8 ESA19899.1 - 2.8e-05 23.8 0.0 3.5e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 CHCH domain COX17 PF05051.8 ESA19899.1 - 0.076 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Sel1 PF08238.7 ESA19901.1 - 1.3e-47 159.1 15.2 1.8e-13 50.6 0.8 5.3 5 0 0 5 5 5 5 Sel1 repeat DisA-linker PF10635.4 ESA19901.1 - 0.012 15.0 0.8 0.074 12.5 0.0 2.5 2 1 0 2 2 2 0 DisA bacterial checkpoint controller linker region TPR_6 PF13174.1 ESA19901.1 - 0.12 12.8 11.8 5.7 7.6 0.2 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA19901.1 - 0.27 11.1 8.1 4.1 7.3 0.1 3.7 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain GpcrRhopsn4 PF10192.4 ESA19902.1 - 0.014 14.6 5.1 0.023 13.8 3.6 1.4 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain Cytochrom_B_N PF00033.14 ESA19902.1 - 0.4 10.0 3.5 0.54 9.5 1.0 2.0 1 1 1 2 2 2 0 Cytochrome b(N-terminal)/b6/petB CD20 PF04103.10 ESA19902.1 - 0.7 9.8 8.4 4.3 7.2 5.2 2.6 1 1 1 2 2 2 0 CD20-like family Pho86 PF11124.3 ESA19903.1 - 0.098 11.6 0.1 0.1 11.5 0.1 1.0 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 zf-RING_2 PF13639.1 ESA19904.1 - 7.6e-16 57.6 6.8 9.5e-16 57.3 4.7 1.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA19904.1 - 1.4e-09 37.8 5.9 1.8e-09 37.4 4.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA19904.1 - 5.6e-09 35.9 7.2 1.8e-08 34.3 5.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA19904.1 - 8.2e-09 34.9 5.9 1.1e-08 34.5 4.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA19904.1 - 1.3e-07 31.2 4.3 1.6e-07 30.9 3.0 1.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA19904.1 - 3e-06 26.7 4.1 4.1e-06 26.3 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA19904.1 - 5.6e-05 22.8 6.7 0.00028 20.6 4.3 1.9 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 ESA19904.1 - 0.00025 21.0 4.6 0.00052 19.9 3.2 1.5 1 1 0 1 1 1 1 RING-variant domain zf-RING_4 PF14570.1 ESA19904.1 - 0.00087 18.8 3.1 0.0012 18.3 2.2 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 ESA19904.1 - 0.0027 17.1 2.9 0.0037 16.7 2.0 1.2 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESA19904.1 - 0.0042 16.7 1.0 0.0042 16.7 0.7 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING-like PF08746.6 ESA19904.1 - 0.0059 16.5 3.9 0.0089 16.0 2.7 1.3 1 0 0 1 1 1 1 RING-like domain PHD PF00628.24 ESA19904.1 - 0.019 14.6 5.6 0.029 14.0 3.9 1.3 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.1 ESA19904.1 - 0.043 13.6 5.3 0.12 12.2 3.7 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.3 ESA19904.1 - 0.064 13.2 6.8 0.44 10.5 4.7 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.1 ESA19904.1 - 0.12 12.1 5.6 1.1 9.0 3.9 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Vps39_2 PF10367.4 ESA19904.1 - 0.21 11.7 5.2 0.12 12.6 0.4 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-P11 PF03854.9 ESA19904.1 - 1.6 8.2 6.2 5.9 6.4 1.7 2.2 2 0 0 2 2 2 0 P-11 zinc finger zf-MIZ PF02891.15 ESA19904.1 - 3.9 7.0 7.3 12 5.5 5.1 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger PA PF02225.17 ESA19905.1 - 8e-08 31.9 0.0 1.4e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 PA domain CTNNBL PF08216.6 ESA19907.1 - 1.6e-35 120.9 2.1 1.6e-35 120.9 1.4 2.7 3 0 0 3 3 3 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.18 ESA19907.1 - 1.5e-05 24.6 0.6 0.013 15.2 0.0 3.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESA19907.1 - 0.029 14.6 0.1 0.61 10.3 0.0 2.7 1 1 0 2 2 2 0 HEAT repeats MFS_1 PF07690.11 ESA19908.1 - 1.2e-14 53.8 20.9 8.6e-11 41.1 11.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA19908.1 - 3.6e-07 29.1 12.4 0.0013 17.3 7.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.15 ESA19908.1 - 0.0016 16.6 0.2 0.0016 16.6 0.1 2.1 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2621 PF11084.3 ESA19908.1 - 0.13 11.9 0.9 0.26 10.9 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) Leuk-A4-hydro_C PF09127.6 ESA19909.1 - 0.02 14.4 0.2 0.038 13.5 0.1 1.3 1 1 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal RICH PF05062.7 ESA19911.1 - 1.8 8.7 6.6 6 7.0 0.3 2.5 2 1 0 2 2 2 0 RICH domain Transposase_21 PF02992.9 ESA19913.1 - 2.8e-10 39.6 0.1 2.9e-10 39.6 0.1 1.0 1 0 0 1 1 1 1 Transposase family tnp2 Uma2 PF05685.7 ESA19915.1 - 2.7e-07 30.0 0.0 4.3e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Putative restriction endonuclease SURF2 PF05477.6 ESA19915.1 - 0.061 12.4 3.9 0.089 11.9 2.7 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Corona_nucleoca PF00937.13 ESA19915.1 - 0.55 9.1 11.0 0.8 8.5 7.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Endosulfine PF04667.12 ESA19918.1 - 1.5e-18 66.5 0.1 2.8e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region DUF2367 PF10164.4 ESA19918.1 - 6 6.7 5.4 4.2 7.2 1.4 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) NARG2_C PF10505.4 ESA19919.1 - 7e-11 41.7 1.6 1.4e-10 40.7 1.1 1.5 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus DUF2283 PF10049.4 ESA19920.1 - 1 9.2 7.0 2.9 7.8 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2283) Aldo_ket_red PF00248.16 ESA19921.1 - 2.3e-13 49.5 0.0 2.6e-07 29.7 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family RNase_T PF00929.19 ESA19922.1 - 4.3e-16 59.6 0.0 9.6e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Exonuclease DUF4105 PF13387.1 ESA19922.1 - 0.0066 15.6 0.3 0.011 14.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4105) F-box-like PF12937.2 ESA19924.1 - 2.9e-13 49.2 0.3 8.9e-13 47.7 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19924.1 - 0.00096 18.7 1.5 0.003 17.1 0.0 2.6 2 0 0 2 2 2 1 F-box domain PRANC PF09372.5 ESA19924.1 - 0.19 11.7 6.3 1.1 9.2 0.1 3.4 4 0 0 4 4 4 0 PRANC domain Glyco_hydro_47 PF01532.15 ESA19926.1 - 1.9e-133 445.4 0.0 2.3e-133 445.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Endonuc-dimeris PF09124.5 ESA19928.1 - 0.00021 20.8 0.6 0.00045 19.7 0.4 1.5 1 0 0 1 1 1 1 T4 recombination endonuclease VII, dimerisation SAP PF02037.22 ESA19928.1 - 0.018 14.5 1.1 0.036 13.5 0.8 1.6 1 0 0 1 1 1 0 SAP domain F-box-like PF12937.2 ESA19929.1 - 0.0037 16.9 2.2 0.0059 16.2 0.2 2.3 2 0 0 2 2 2 1 F-box-like SPT16 PF08644.6 ESA19929.1 - 0.0064 16.3 0.5 0.019 14.7 0.3 1.9 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) RraB PF06877.6 ESA19931.1 - 0.054 14.1 0.1 0.14 12.7 0.0 1.6 2 0 0 2 2 2 0 Regulator of ribonuclease activity B PG_binding_1 PF01471.13 ESA19932.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Chalcone PF02431.10 ESA19932.1 - 0.45 9.8 10.5 1 8.6 0.9 2.8 1 1 2 3 3 3 0 Chalcone-flavanone isomerase PNPase PF03726.9 ESA19932.1 - 3.1 8.1 10.2 11 6.3 0.0 3.7 2 1 1 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF3692 PF12469.3 ESA19932.1 - 6.3 7.0 10.0 10 6.3 4.3 3.3 1 1 0 2 2 2 0 CRISPR-associated protein F-box-like PF12937.2 ESA19934.1 - 9.8e-05 22.0 1.2 0.00037 20.1 0.8 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19934.1 - 0.033 13.8 1.4 0.12 12.0 0.1 2.6 2 0 0 2 2 2 0 F-box domain Endonuc-MspI PF09208.5 ESA19935.1 - 0.00012 21.2 2.0 0.00013 21.1 1.4 1.0 1 0 0 1 1 1 1 Restriction endonuclease MspI PBC PF03792.8 ESA19935.1 - 0.041 13.5 1.0 0.043 13.5 0.7 1.0 1 0 0 1 1 1 0 PBC domain ubiquitin PF00240.18 ESA19938.1 - 2.2e-34 116.6 4.5 1.1e-19 69.5 0.3 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 ESA19938.1 - 7.7e-20 70.3 3.4 7.8e-11 41.5 0.2 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA19938.1 - 1.1e-05 25.6 2.4 0.25 11.6 0.4 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain CTDII PF01556.13 ESA19938.1 - 0.023 14.5 1.0 0.1 12.5 0.2 2.0 2 0 0 2 2 2 0 DnaJ C terminal domain YukD PF08817.5 ESA19938.1 - 0.15 12.6 0.0 2 9.0 0.0 2.2 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Plexin_cytopl PF08337.7 ESA19938.1 - 0.18 10.0 1.2 4.4 5.5 0.1 2.5 2 1 1 3 3 3 0 Plexin cytoplasmic RasGAP domain IBR PF01485.16 ESA19939.1 - 8.3e-16 57.6 46.5 8.9e-10 38.3 3.5 4.2 3 1 1 4 4 4 3 IBR domain C1_4 PF07975.7 ESA19939.1 - 0.0093 15.9 5.4 0.0093 15.9 3.7 4.6 2 2 2 4 4 4 1 TFIIH C1-like domain ELK PF03789.8 ESA19941.1 - 3.4 7.6 5.5 7.2 6.5 0.1 2.3 2 0 0 2 2 2 0 ELK domain PIN PF01850.16 ESA19947.1 - 0.0018 18.6 1.1 0.0055 17.0 0.3 1.9 1 1 0 2 2 2 1 PIN domain FCH PF00611.18 ESA19947.1 - 0.039 14.1 2.9 0.07 13.3 1.8 1.7 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain DUF262 PF03235.9 ESA19947.1 - 0.61 10.0 4.6 0.74 9.7 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 PIN PF01850.16 ESA19948.1 - 0.007 16.6 0.5 0.013 15.8 0.2 1.5 1 1 0 1 1 1 1 PIN domain DUF262 PF03235.9 ESA19948.1 - 0.045 13.7 0.5 0.061 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF1287 PF06940.6 ESA19949.1 - 0.027 13.9 0.1 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) LolA PF03548.10 ESA19949.1 - 0.066 12.8 0.9 0.11 12.0 0.6 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA DUF2779 PF11074.3 ESA19949.1 - 0.07 13.1 1.2 0.33 10.9 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) Peptidase_C39 PF03412.10 ESA19950.1 - 0.013 15.2 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 Peptidase C39 family DUF4286 PF14114.1 ESA19950.1 - 0.017 15.3 0.0 5.5 7.3 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) RNase_H PF00075.19 ESA19952.1 - 1.2e-12 48.2 2.6 5.7e-12 46.1 0.9 2.5 2 1 0 2 2 2 1 RNase H DUF2018 PF09442.5 ESA19953.1 - 0.0067 16.9 2.1 0.014 15.9 0.7 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF2018) HsdM_N PF12161.3 ESA19953.1 - 0.059 13.7 0.8 0.094 13.1 0.6 1.5 1 1 0 1 1 1 0 HsdM N-terminal domain Sec62 PF03839.11 ESA19954.1 - 3.3 7.0 5.6 1.5 8.1 1.3 1.9 2 0 0 2 2 2 0 Translocation protein Sec62 RRM_6 PF14259.1 ESA19955.1 - 3.5e-07 30.0 0.0 0.0012 18.7 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA19955.1 - 1.3e-05 24.7 0.1 0.0017 17.9 0.0 2.9 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.18 ESA19955.1 - 0.0015 18.3 2.4 0.0033 17.2 1.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA19955.1 - 0.013 15.0 3.0 0.029 13.8 2.1 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.1 ESA19955.1 - 0.9 9.2 6.1 0.24 11.0 1.0 2.3 2 0 0 2 2 2 0 Zinc knuckle Phage_1_1 PF08200.6 ESA19955.1 - 1.4 9.1 12.8 0.85 9.8 2.9 3.0 3 0 0 3 3 3 0 Bacteriophage 1.1 Protein RVT_1 PF00078.22 ESA19956.1 - 3.5e-06 26.5 0.8 1e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) ACP PF06857.6 ESA19956.1 - 0.1 12.5 0.1 2 8.3 0.0 2.7 2 0 0 2 2 2 0 Malonate decarboxylase delta subunit (MdcD) p450 PF00067.17 ESA19957.1 - 2.3e-58 197.8 0.1 2.8e-58 197.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phosphoesterase PF04185.9 ESA19958.1 - 2.2e-20 73.2 3.7 2.6e-19 69.6 1.1 2.0 2 0 0 2 2 2 2 Phosphoesterase family Pkinase PF00069.20 ESA19959.1 - 5.7e-72 241.9 0.0 6.4e-72 241.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA19959.1 - 1.5e-41 142.2 0.0 1.9e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA19959.1 - 9.9e-08 31.2 0.0 1.9e-07 30.3 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA19959.1 - 0.0016 17.8 0.1 0.0024 17.2 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA19959.1 - 0.0059 16.3 0.0 0.0086 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Phage_T7_Capsid PF05396.6 ESA19959.1 - 0.063 13.4 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 Phage T7 capsid assembly protein Kdo PF06293.9 ESA19959.1 - 0.088 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KA1 PF02149.14 ESA19960.1 - 1.4e-07 30.7 0.3 2.6e-07 29.9 0.0 1.6 2 0 0 2 2 2 1 Kinase associated domain 1 3Beta_HSD PF01073.14 ESA19961.1 - 1.5e-18 66.5 0.0 6.1e-18 64.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 ESA19961.1 - 6.6e-18 64.5 0.0 3e-17 62.3 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.16 ESA19961.1 - 6.5e-15 55.2 0.0 8.9e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESA19961.1 - 5.4e-12 46.1 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 ESA19961.1 - 6.5e-07 28.5 0.0 9.1e-07 28.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.8 ESA19961.1 - 2e-06 27.2 0.0 2.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.10 ESA19961.1 - 2.5e-06 26.6 0.0 3.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 ESA19961.1 - 0.00086 19.2 0.0 0.0025 17.7 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA19961.1 - 0.0045 16.6 0.0 0.014 15.0 0.0 1.7 1 1 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 ESA19961.1 - 0.026 13.4 0.2 0.14 11.1 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase DUF2232 PF09991.4 ESA19961.1 - 0.12 11.3 0.2 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Transposase_21 PF02992.9 ESA19963.1 - 7.6e-08 31.7 0.0 1.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Transposase family tnp2 DUF4218 PF13960.1 ESA19963.1 - 0.00022 20.6 0.2 0.002 17.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) TLD PF07534.11 ESA19965.1 - 2.7e-14 53.3 0.1 9.9e-14 51.5 0.1 2.0 1 0 0 1 1 1 1 TLD ZZ PF00569.12 ESA19965.1 - 1.5e-08 34.0 13.5 1.5e-08 34.0 9.3 2.8 2 1 0 2 2 2 1 Zinc finger, ZZ type BACK PF07707.10 ESA19965.1 - 0.00019 21.2 0.1 0.0011 18.7 0.0 2.2 1 1 0 2 2 2 1 BTB And C-terminal Kelch RdRP PF05183.7 ESA19967.1 - 5.6e-06 25.3 0.0 5.6e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pkinase PF00069.20 ESA19968.1 - 0.061 12.4 0.2 0.072 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein kinase domain DUF4419 PF14388.1 ESA19969.1 - 1.4e-35 122.9 1.9 2.7e-33 115.4 1.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4419) DUF3069 PF11269.3 ESA19969.1 - 0.051 13.6 0.0 0.086 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) Nodulin-like PF06813.8 ESA19969.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Nodulin-like DUF3622 PF12286.3 ESA19969.1 - 0.15 12.3 0.1 0.33 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3622) DUF4419 PF14388.1 ESA19970.1 - 0.00054 19.2 0.0 0.00082 18.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) NAD_Gly3P_dh_N PF01210.18 ESA19971.1 - 9.7e-53 178.1 1.7 1.3e-52 177.6 0.7 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 ESA19971.1 - 1.6e-52 177.1 0.1 2.9e-52 176.3 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.12 ESA19971.1 - 0.0027 18.0 1.8 0.02 15.3 0.8 2.7 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent RNA_pol_Rpb2_1 PF04563.10 ESA19973.1 - 3.8e-37 127.1 0.2 6.3e-37 126.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.11 ESA19973.1 - 3.6e-25 87.5 0.0 8.8e-25 86.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 ESA19973.1 - 4.8e-24 84.0 0.0 1e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.9 ESA19973.1 - 3.9e-14 52.5 0.1 6.5e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 TFIIS_C PF01096.13 ESA19974.1 - 3.5e-19 68.1 7.0 3.5e-19 68.1 4.9 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 ESA19974.1 - 2.7e-09 36.5 1.4 2.7e-09 36.5 0.9 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit zf-C3HC PF07967.8 ESA19974.1 - 0.0086 15.8 0.3 0.0086 15.8 0.2 2.1 1 1 0 2 2 2 1 C3HC zinc finger-like Baculo_LEF5_C PF11792.3 ESA19974.1 - 0.011 15.1 4.0 0.011 15.1 2.8 2.2 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain Zn_ribbon_recom PF13408.1 ESA19974.1 - 0.014 15.5 6.4 0.12 12.6 0.2 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DRP PF06044.7 ESA19974.1 - 0.022 13.7 0.8 0.022 13.7 0.6 2.0 1 1 1 2 2 2 0 Dam-replacing family Zn_Tnp_IS1595 PF12760.2 ESA19974.1 - 0.035 13.9 17.1 0.057 13.2 4.2 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-ISL3 PF14690.1 ESA19974.1 - 0.085 12.8 7.5 2.7 8.1 0.9 3.0 2 1 1 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_2 PF13240.1 ESA19974.1 - 0.79 9.2 10.3 3.4 7.2 0.7 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-DNA_Pol PF08996.5 ESA19974.1 - 0.96 8.7 6.4 0.056 12.7 0.5 1.8 2 0 0 2 2 2 0 DNA Polymerase alpha zinc finger Trm112p PF03966.11 ESA19974.1 - 4.2 7.8 7.1 1e+02 3.3 4.5 2.5 1 1 1 2 2 2 0 Trm112p-like protein Lar_restr_allev PF14354.1 ESA19974.1 - 5.5 7.3 13.5 3.1e+03 -1.5 9.4 2.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar TF_Zn_Ribbon PF08271.7 ESA19974.1 - 7 6.0 8.0 8.3 5.8 0.1 2.8 3 0 0 3 3 3 0 TFIIB zinc-binding CK_II_beta PF01214.13 ESA19974.1 - 8.9 5.7 9.4 0.12 11.8 0.7 2.0 1 1 2 3 3 3 0 Casein kinase II regulatory subunit UPF0172 PF03665.8 ESA19975.1 - 4.2e-55 186.2 0.1 5e-55 186.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) DUF4441 PF14536.1 ESA19975.1 - 0.34 10.8 8.4 0.18 11.8 0.9 2.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4441) AAA_5 PF07728.9 ESA19977.1 - 1.5e-09 37.7 0.0 4.2e-05 23.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA PF00004.24 ESA19977.1 - 2e-09 37.7 0.0 0.00061 20.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 ESA19977.1 - 1.5e-05 25.0 0.0 0.064 13.3 0.0 2.8 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 ESA19977.1 - 2.7e-05 24.2 0.0 0.0056 16.8 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESA19977.1 - 0.00055 19.8 0.0 0.0034 17.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 ESA19977.1 - 0.0018 18.7 0.0 0.0052 17.2 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 ESA19977.1 - 0.0029 17.6 0.0 0.81 9.6 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.13 ESA19977.1 - 0.0039 16.7 0.0 0.023 14.2 0.0 2.2 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 ESA19977.1 - 0.01 16.0 0.0 0.29 11.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.7 ESA19977.1 - 0.012 15.2 0.0 0.14 11.7 0.0 2.6 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.22 ESA19977.1 - 0.016 15.4 0.0 0.65 10.2 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.1 ESA19977.1 - 0.042 13.6 0.0 3.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain Arch_ATPase PF01637.13 ESA19977.1 - 0.048 13.3 0.0 2.6 7.6 0.0 2.9 2 1 0 2 2 2 0 Archaeal ATPase DUF2075 PF09848.4 ESA19977.1 - 0.11 11.4 0.0 6.8 5.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) T2SE PF00437.15 ESA19977.1 - 0.14 11.0 0.0 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.1 ESA19977.1 - 0.17 12.7 0.1 2.6 8.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA PF00004.24 ESA19978.1 - 4.9e-09 36.4 0.0 0.0014 18.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA19978.1 - 5e-09 35.9 0.0 0.00016 21.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 ESA19978.1 - 8.8e-06 25.8 0.0 0.031 14.3 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 ESA19978.1 - 5.8e-05 23.2 0.0 0.011 15.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESA19978.1 - 0.0011 18.8 0.0 0.0072 16.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA19978.1 - 0.0024 17.9 0.0 0.68 9.8 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain Miro PF08477.8 ESA19978.1 - 0.0034 17.8 0.0 0.0089 16.5 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein RNA_helicase PF00910.17 ESA19978.1 - 0.0058 16.7 0.0 0.3 11.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.7 ESA19978.1 - 0.0091 15.6 0.0 0.15 11.7 0.0 2.6 3 0 0 3 3 3 1 NACHT domain DUF2075 PF09848.4 ESA19978.1 - 0.01 14.8 0.0 0.44 9.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.13 ESA19978.1 - 0.015 14.7 0.0 0.088 12.3 0.0 2.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 ESA19978.1 - 0.017 15.4 0.0 0.96 9.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter Arch_ATPase PF01637.13 ESA19978.1 - 0.036 13.7 0.2 1.9 8.1 0.0 3.0 2 2 1 3 3 3 0 Archaeal ATPase AAA_19 PF13245.1 ESA19978.1 - 0.041 13.6 0.0 3.7 7.3 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain Sigma54_activat PF00158.21 ESA19978.1 - 0.15 11.5 0.0 7.5 6.0 0.0 3.2 3 1 1 4 4 4 0 Sigma-54 interaction domain T2SE PF00437.15 ESA19978.1 - 0.18 10.6 0.0 0.31 9.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RicinB_lectin_2 PF14200.1 ESA19979.1 - 4.1e-10 39.9 4.1 1.2e-09 38.4 2.9 1.9 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA19979.1 - 0.0016 18.4 5.4 0.0096 15.9 1.0 2.2 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RTX_C PF08339.5 ESA19982.1 - 0.13 12.0 0.3 0.12 12.0 0.2 1.1 1 0 0 1 1 1 0 RTX C-terminal domain Peptidase_M13_N PF05649.8 ESA19988.1 - 5.2e-107 358.2 0.1 7.3e-107 357.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.16 ESA19988.1 - 3.1e-65 219.2 0.1 5e-65 218.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M13 Septin PF00735.13 ESA19989.1 - 6.8e-118 392.7 2.5 1e-117 392.1 1.7 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 ESA19989.1 - 2.2e-08 34.0 0.0 4.7e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA19989.1 - 2.6e-07 30.2 2.2 2.3e-06 27.1 0.2 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 ESA19989.1 - 2.4e-06 26.8 0.1 5.9e-06 25.5 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 ESA19989.1 - 0.00019 20.6 0.1 0.00045 19.3 0.1 1.6 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 ESA19989.1 - 0.00022 21.6 0.1 0.00063 20.2 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 ESA19989.1 - 0.00034 20.7 1.4 0.0041 17.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain Ras PF00071.17 ESA19989.1 - 0.0012 18.2 1.0 0.0043 16.4 0.7 2.0 1 1 0 1 1 1 1 Ras family PduV-EutP PF10662.4 ESA19989.1 - 0.0013 18.2 2.8 0.035 13.5 0.5 2.8 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.8 ESA19989.1 - 0.0017 17.2 0.0 0.0033 16.2 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.1 ESA19989.1 - 0.0038 16.8 0.4 0.0079 15.8 0.3 1.5 1 0 0 1 1 1 1 AAA domain Pox_A32 PF04665.7 ESA19989.1 - 0.0052 16.1 0.2 0.012 14.9 0.1 1.6 1 0 0 1 1 1 1 Poxvirus A32 protein ABC_tran PF00005.22 ESA19989.1 - 0.0076 16.5 1.8 0.015 15.6 0.0 2.2 2 1 0 2 2 2 1 ABC transporter AAA_33 PF13671.1 ESA19989.1 - 0.015 15.1 0.3 0.16 11.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 ESA19989.1 - 0.016 14.8 0.1 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 ESA19989.1 - 0.017 14.8 0.3 0.04 13.6 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activat PF00158.21 ESA19989.1 - 0.026 13.9 0.1 0.052 13.0 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.13 ESA19989.1 - 0.026 13.9 1.9 0.035 13.5 0.1 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.2 ESA19989.1 - 0.029 13.8 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Gtr1_RagA PF04670.7 ESA19989.1 - 0.034 13.2 0.0 0.13 11.4 0.0 2.0 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.1 ESA19989.1 - 0.037 13.9 0.6 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.17 ESA19989.1 - 0.058 13.5 0.1 0.22 11.7 0.1 2.0 1 1 0 1 1 1 0 RNA helicase Dynamin_N PF00350.18 ESA19989.1 - 0.068 12.9 10.7 0.34 10.7 0.1 3.3 2 1 1 3 3 3 0 Dynamin family AAA_29 PF13555.1 ESA19989.1 - 0.081 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.12 ESA19989.1 - 0.091 12.2 1.1 2.7 7.4 0.1 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Ribosomal_S17 PF00366.15 ESA19990.1 - 1.8e-29 101.5 1.4 2.8e-29 100.9 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 TPR_11 PF13414.1 ESA19991.1 - 0.0001 21.8 0.9 0.25 10.9 0.2 3.4 3 1 0 3 3 3 2 TPR repeat FGF-BP1 PF06473.7 ESA19991.1 - 0.042 13.4 0.4 0.08 12.5 0.3 1.4 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) TPR_16 PF13432.1 ESA19991.1 - 0.13 13.0 0.0 8.6 7.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Frizzled PF01534.12 ESA19992.1 - 4.9e-11 41.9 3.2 7.2e-11 41.4 2.3 1.3 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.17 ESA19992.1 - 2.5e-06 27.8 1.3 6.4e-06 26.5 0.9 1.8 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.6 ESA19992.1 - 4.3e-06 25.8 4.4 9.9e-06 24.6 3.0 1.6 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.19 ESA19992.1 - 7.1e-06 25.2 2.3 1.1e-05 24.7 1.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) F-box-like PF12937.2 ESA19997.1 - 3.9e-07 29.6 3.1 1.1e-06 28.2 2.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA19997.1 - 2.4 7.9 7.0 3.7 7.3 0.8 3.7 3 1 0 3 3 3 0 F-box domain Chitin_synth_1 PF01644.12 ESA19998.1 - 0.1 12.3 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 Chitin synthase Uma2 PF05685.7 ESA19999.1 - 1.8e-14 53.4 0.1 2.4e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-C2H2_4 PF13894.1 ESA19999.1 - 0.00017 21.6 0.5 0.00035 20.7 0.3 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA19999.1 - 0.0012 19.0 0.2 0.0025 18.0 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESA19999.1 - 0.0044 17.1 1.0 0.0071 16.4 0.7 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-rbx1 PF12678.2 ESA20000.1 - 8.2e-05 22.6 2.3 0.034 14.2 0.1 2.3 2 0 0 2 2 2 2 RING-H2 zinc finger zf-RING_2 PF13639.1 ESA20000.1 - 0.00011 21.9 8.7 0.003 17.3 0.3 2.6 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.1 ESA20000.1 - 0.00026 20.9 8.3 0.062 13.3 1.3 2.9 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA20000.1 - 0.00085 19.0 0.3 0.00085 19.0 0.2 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA20000.1 - 0.0034 17.0 4.0 0.17 11.6 0.1 2.6 2 0 0 2 2 2 2 RING-type zinc-finger Prok-RING_1 PF14446.1 ESA20000.1 - 0.017 14.8 9.1 0.81 9.4 0.5 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.17 ESA20000.1 - 0.034 13.8 2.0 6.5 6.5 0.0 2.7 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Apc11 PF12861.2 ESA20000.1 - 0.14 11.9 4.6 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger TSC22 PF01166.13 ESA20001.1 - 0.00013 21.7 2.7 0.00013 21.7 1.9 2.7 2 1 0 2 2 2 1 TSC-22/dip/bun family bZIP_1 PF00170.16 ESA20001.1 - 0.0081 16.1 2.3 0.0081 16.1 1.6 2.5 1 1 1 2 2 2 1 bZIP transcription factor DUF1875 PF08961.5 ESA20001.1 - 0.014 14.7 10.8 0.027 13.7 2.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1875) Shugoshin_N PF07558.6 ESA20001.1 - 0.015 14.9 2.0 0.015 14.9 1.4 3.4 2 2 1 3 3 3 0 Shugoshin N-terminal coiled-coil region DUF2216 PF10226.4 ESA20001.1 - 0.038 13.5 7.2 1.6 8.1 4.9 2.1 1 1 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) HALZ PF02183.13 ESA20001.1 - 0.043 13.5 6.8 0.3 10.8 0.5 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper bZIP_2 PF07716.10 ESA20001.1 - 0.048 13.4 1.9 0.048 13.4 1.3 3.2 2 1 1 3 3 3 0 Basic region leucine zipper WD40_alt PF14077.1 ESA20001.1 - 0.05 13.2 1.0 0.087 12.4 0.7 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif Draxin PF15550.1 ESA20001.1 - 0.064 12.9 1.7 0.074 12.7 1.2 1.0 1 0 0 1 1 1 0 Draxin DUF724 PF05266.9 ESA20001.1 - 0.07 12.7 6.0 0.099 12.2 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Fez1 PF06818.10 ESA20001.1 - 0.11 12.5 5.7 0.14 12.1 3.9 1.3 1 0 0 1 1 1 0 Fez1 DUF1635 PF07795.6 ESA20001.1 - 0.12 11.7 5.8 0.14 11.4 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) PEARLI-4 PF05278.7 ESA20001.1 - 0.17 11.2 4.8 0.079 12.3 1.4 1.7 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF778 PF05608.7 ESA20001.1 - 0.19 11.6 0.8 0.24 11.3 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF778) DivIC PF04977.10 ESA20001.1 - 0.29 10.6 14.0 0.03 13.7 3.6 2.3 1 1 1 2 2 2 0 Septum formation initiator DUF904 PF06005.7 ESA20001.1 - 0.31 11.3 17.0 0.46 10.8 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) OmpH PF03938.9 ESA20001.1 - 0.41 10.5 8.0 0.58 10.0 5.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF972 PF06156.8 ESA20001.1 - 0.65 10.3 13.0 0.34 11.2 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IFP_35_N PF07334.8 ESA20001.1 - 0.7 9.8 5.2 0.22 11.5 0.9 2.1 1 1 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus IncA PF04156.9 ESA20001.1 - 0.76 9.3 7.5 1.3 8.6 5.2 1.4 1 0 0 1 1 1 0 IncA protein Occludin_ELL PF07303.8 ESA20001.1 - 0.95 10.2 5.5 2.2 9.0 3.8 1.6 1 1 0 1 1 1 0 Occludin homology domain APG6 PF04111.7 ESA20001.1 - 1.1 8.2 10.0 1.4 7.8 6.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Tup_N PF08581.5 ESA20001.1 - 1.2 9.3 6.4 0.13 12.5 0.8 2.0 2 1 0 2 2 2 0 Tup N-terminal DUF334 PF03904.8 ESA20001.1 - 1.2 8.3 5.1 1.5 8.0 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Fmp27_WPPW PF10359.4 ESA20001.1 - 1.8 6.8 8.0 2.1 6.6 5.5 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2205 PF10224.4 ESA20001.1 - 2.8 7.5 9.4 0.97 9.0 1.2 2.5 1 1 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Pox_A_type_inc PF04508.7 ESA20001.1 - 5.3 7.0 6.0 4.2 7.4 1.2 3.0 2 1 1 3 3 3 0 Viral A-type inclusion protein repeat TerD PF02342.13 ESA20002.1 - 7.5e-15 54.7 0.0 1.3e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.18 ESA20002.1 - 4e-08 32.5 1.2 1.1e-07 31.1 0.8 1.7 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA20002.1 - 0.001 18.7 0.4 0.0022 17.6 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RING_5 PF14634.1 ESA20002.1 - 0.028 14.1 7.0 0.056 13.1 4.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA20002.1 - 0.051 13.6 4.2 0.13 12.3 2.9 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA20002.1 - 0.11 12.2 7.0 0.3 10.7 4.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA20002.1 - 2.7 7.9 6.8 0.28 11.0 1.5 1.8 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Spore_GerAC PF05504.6 ESA20003.1 - 0.0068 16.1 0.1 0.0079 15.9 0.1 1.1 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DUF1958 PF09211.5 ESA20003.1 - 0.011 15.8 0.2 0.022 14.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1958) SAP30_Sin3_bdg PF13867.1 ESA20003.1 - 0.04 13.7 0.4 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DLD PF14878.1 ESA20003.1 - 0.08 13.0 0.1 0.093 12.8 0.1 1.2 1 0 0 1 1 1 0 Death-like domain of SPT6 GerE PF00196.14 ESA20006.1 - 0.037 13.3 0.2 0.059 12.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Kelch_3 PF13415.1 ESA20009.1 - 3.3e-12 46.1 0.9 9.6e-09 35.1 0.1 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA20009.1 - 3.1e-09 36.5 0.2 4.4e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 ESA20009.1 - 1.7e-07 31.1 3.4 0.0017 18.4 0.1 2.6 1 1 1 2 2 2 2 Kelch motif Kelch_2 PF07646.10 ESA20009.1 - 1e-06 28.2 0.5 0.012 15.3 0.0 3.1 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 ESA20009.1 - 6.5e-05 22.6 5.5 0.0018 18.0 0.0 2.8 3 0 0 3 3 2 2 Galactose oxidase, central domain DUF912 PF06024.7 ESA20009.1 - 0.0013 18.7 1.4 0.0023 17.9 0.4 1.8 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF2970 PF11174.3 ESA20009.1 - 0.015 14.8 0.3 0.028 14.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) WTF PF03303.8 ESA20009.1 - 0.015 14.7 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 WTF protein TMEM154 PF15102.1 ESA20009.1 - 0.065 12.9 0.2 0.065 12.9 0.2 1.7 2 0 0 2 2 2 0 TMEM154 protein family CD34_antigen PF06365.7 ESA20009.1 - 0.1 12.2 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Rax2 PF12768.2 ESA20009.1 - 0.13 11.4 6.7 0.061 12.5 1.5 2.0 1 1 1 2 2 2 0 Cortical protein marker for cell polarity DUF3753 PF12575.3 ESA20009.1 - 0.15 11.8 2.1 0.31 10.8 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Kelch_1 PF01344.20 ESA20009.1 - 0.18 11.3 5.8 1.2 8.7 0.9 2.8 2 1 0 2 2 2 0 Kelch motif DUF106 PF01956.11 ESA20009.1 - 0.22 11.0 1.6 0.42 10.1 1.1 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 Rifin_STEVOR PF02009.11 ESA20009.1 - 0.68 9.5 2.2 0.92 9.0 1.6 1.2 1 0 0 1 1 1 0 Rifin/stevor family Glycophorin_A PF01102.13 ESA20009.1 - 2.3 7.9 10.5 0.11 12.2 1.5 2.4 2 1 0 2 2 2 0 Glycophorin A EVI2A PF05399.6 ESA20009.1 - 2.8 7.1 7.0 0.11 11.6 0.4 1.8 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) DNA_pol3_a_NII PF11490.3 ESA20010.1 - 0.068 12.7 0.7 0.068 12.7 0.5 1.9 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Aha1_N PF09229.6 ESA20012.1 - 0.0036 17.1 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal Lon_C PF05362.8 ESA20015.1 - 2.1e-68 229.6 0.0 3.6e-68 228.9 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 ESA20015.1 - 1.1e-35 123.2 1.3 3.6e-35 121.5 0.9 2.0 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 ESA20015.1 - 1e-22 80.7 0.0 2.7e-22 79.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA20015.1 - 1.1e-06 28.4 0.0 2.8e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESA20015.1 - 1.9e-06 27.9 0.0 6.5e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.1 ESA20015.1 - 1.9e-06 27.3 0.0 3.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.6 ESA20015.1 - 3.4e-05 22.6 0.0 7.3e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.7 ESA20015.1 - 0.00012 21.2 0.0 0.0015 17.6 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 ESA20015.1 - 0.00016 21.6 0.2 0.0029 17.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 ESA20015.1 - 0.00048 20.2 0.1 0.009 16.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA20015.1 - 0.00074 20.3 0.0 0.0031 18.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA20015.1 - 0.0081 16.0 0.0 0.042 13.7 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 ESA20015.1 - 0.012 15.8 1.7 0.04 14.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESA20015.1 - 0.022 14.9 0.0 0.065 13.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.1 ESA20015.1 - 0.023 14.0 0.0 0.059 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 ESA20015.1 - 0.027 14.1 0.0 0.064 12.9 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SKI PF01202.17 ESA20015.1 - 0.027 14.3 0.0 0.083 12.7 0.0 1.8 1 0 0 1 1 1 0 Shikimate kinase IstB_IS21 PF01695.12 ESA20015.1 - 0.038 13.4 0.0 0.093 12.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF258 PF03193.11 ESA20015.1 - 0.048 12.8 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 F-box-like PF12937.2 ESA20017.1 - 1.9e-07 30.6 0.3 4.9e-07 29.3 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA20019.1 - 9.7e-06 25.2 0.7 2e-05 24.2 0.5 1.6 1 0 0 1 1 1 1 F-box-like GDPD PF03009.12 ESA20024.1 - 1.5e-31 109.8 0.1 5.6e-31 107.9 0.0 1.8 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.14 ESA20024.1 - 0.09 12.1 0.1 13 5.1 0.1 2.2 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain DUF3132 PF11330.3 ESA20024.1 - 0.23 11.2 1.9 2.5 7.9 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3132) PQ-loop PF04193.9 ESA20025.1 - 3.2e-19 68.2 14.7 8.7e-15 54.0 1.1 3.2 2 1 1 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.13 ESA20025.1 - 9.4e-05 22.9 2.9 0.00015 22.3 2.0 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Ycf66_N PF07444.6 ESA20025.1 - 8.1 6.2 10.0 0.074 12.7 0.8 2.2 3 0 0 3 3 3 0 Ycf66 protein N-terminus PUL PF08324.6 ESA20026.1 - 0.05 12.3 0.2 0.083 11.6 0.1 1.3 1 0 0 1 1 1 0 PUL domain Uma2 PF05685.7 ESA20027.1 - 0.0022 17.3 0.0 0.047 13.0 0.0 2.1 1 1 1 2 2 2 2 Putative restriction endonuclease Pkinase_Tyr PF07714.12 ESA20028.1 - 1.2e-34 119.5 0.0 1.9e-34 118.9 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20028.1 - 2.8e-32 111.8 0.0 3.8e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA20028.1 - 0.00095 18.5 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 ESA20028.1 - 0.0022 17.0 0.0 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 ESA20028.1 - 0.0054 15.9 0.0 0.0078 15.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA20028.1 - 0.012 15.3 0.1 0.026 14.2 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA20030.1 - 7.1e-12 45.0 0.3 8.1e-12 44.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20030.1 - 1.2e-09 37.6 0.0 1.4e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA20030.1 - 0.054 12.5 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA20031.1 - 9.8e-21 74.0 5.5 1.3e-20 73.6 3.8 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20031.1 - 3.7e-13 49.1 1.4 5e-13 48.7 1.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA20031.1 - 0.00062 18.8 0.3 0.0012 17.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA20031.1 - 0.011 14.7 0.0 0.014 14.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.4 ESA20031.1 - 0.048 12.9 0.1 0.096 12.0 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ATP-synt_DE_N PF02823.11 ESA20032.1 - 5.5e-16 58.0 0.0 7.6e-16 57.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Cecropin PF00272.14 ESA20038.1 - 0.093 12.3 0.5 12 5.5 0.0 2.2 2 0 0 2 2 2 0 Cecropin family Mg_trans_NIPA PF05653.9 ESA20040.1 - 1.3e-27 96.6 14.9 1.6e-14 53.5 3.2 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA20040.1 - 2.6e-05 24.3 3.0 2.6e-05 24.3 2.0 2.9 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA20040.1 - 0.0022 18.0 8.6 0.0022 18.0 5.9 2.9 2 1 1 3 3 3 1 EamA-like transporter family DUF4131 PF13567.1 ESA20040.1 - 0.23 10.8 13.2 1.1 8.6 3.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Ndc1_Nup PF09531.5 ESA20043.1 - 0.059 11.7 1.2 0.061 11.7 0.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pox_A12 PF04651.8 ESA20043.1 - 0.55 10.3 6.8 0.72 9.9 4.7 1.1 1 0 0 1 1 1 0 Poxvirus A12 protein Pkinase_Tyr PF07714.12 ESA20044.1 - 1e-07 31.3 0.2 2.1e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pyr_redox_2 PF07992.9 ESA20045.1 - 0.053 13.3 0.0 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AAA PF00004.24 ESA20046.1 - 3.6e-34 117.8 0.0 7.6e-34 116.7 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 ESA20046.1 - 2.1e-08 33.4 0.0 3.4e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Vps4_C PF09336.5 ESA20046.1 - 7e-06 25.8 0.3 5.2e-05 23.0 0.0 2.5 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.9 ESA20046.1 - 1.9e-05 24.3 0.4 0.00076 19.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 ESA20046.1 - 0.00013 21.6 0.1 0.001 18.7 0.0 2.3 2 1 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 ESA20046.1 - 0.00018 21.6 0.1 0.0083 16.2 0.1 2.6 1 1 0 1 1 1 1 AAA domain Ribosomal_L50 PF10501.4 ESA20046.1 - 0.00078 19.3 0.1 0.0019 18.1 0.0 1.6 2 0 0 2 2 2 1 Ribosomal subunit 39S Mg_chelatase PF01078.16 ESA20046.1 - 0.025 13.7 0.0 0.05 12.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 ESA20046.1 - 0.037 13.5 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESA20046.1 - 0.051 12.9 0.1 2.5 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 ESA20046.1 - 0.054 13.4 0.5 0.25 11.2 0.3 2.2 1 1 0 1 1 1 0 AAA ATPase domain Bac_DnaA PF00308.13 ESA20046.1 - 0.079 12.5 0.7 0.22 11.1 0.1 2.0 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_17 PF13207.1 ESA20046.1 - 0.081 13.7 0.4 0.18 12.6 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.9 ESA20046.1 - 0.085 12.7 0.0 0.19 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 ESA20046.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein HMG_box PF00505.14 ESA20047.1 - 3.7e-18 65.5 7.9 1.6e-12 47.5 0.9 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA20047.1 - 1.4e-13 50.9 6.3 3.3e-10 40.1 0.8 2.6 2 1 0 2 2 2 2 HMG-box domain KRAB PF01352.22 ESA20047.1 - 0.22 11.0 1.1 1 8.8 0.0 2.6 2 1 0 2 2 2 0 KRAB box Hexapep PF00132.19 ESA20048.1 - 6e-14 50.8 16.3 6.3e-11 41.2 5.8 3.6 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 ESA20048.1 - 2.3e-12 46.2 13.0 1.1e-09 37.7 4.7 2.8 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Acetyltransf_11 PF13720.1 ESA20048.1 - 0.0071 16.5 0.2 0.01 16.0 0.1 1.2 1 0 0 1 1 1 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Gly_acyl_tr_N PF06021.6 ESA20049.1 - 0.05 13.0 0.1 0.056 12.8 0.1 1.0 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase TPP_enzyme_N PF02776.13 ESA20050.1 - 3.7e-37 127.4 0.0 6.3e-37 126.7 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 ESA20050.1 - 3.6e-27 94.8 0.0 8e-27 93.6 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 ESA20050.1 - 1.7e-18 66.6 0.0 8.6e-18 64.3 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.15 ESA20050.1 - 0.004 15.9 0.0 0.0066 15.2 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 ESA20050.1 - 0.006 15.5 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase HupH_C PF04809.8 ESA20050.1 - 0.058 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 HupH hydrogenase expression protein, C-terminal conserved region Ish1 PF10281.4 ESA20051.1 - 3.4 7.8 7.8 1.2 9.2 3.3 2.0 1 1 1 2 2 2 0 Putative stress-responsive nuclear envelope protein HTH_29 PF13551.1 ESA20052.1 - 4.3e-06 26.8 0.0 6.6e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA20052.1 - 6.9e-06 25.5 0.2 4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS630 PF01710.11 ESA20052.1 - 2.2e-05 24.1 0.7 3.4e-05 23.4 0.5 1.2 1 0 0 1 1 1 1 Transposase Sigma70_r4_2 PF08281.7 ESA20052.1 - 3.4e-05 23.2 0.0 7.1e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 MarR_2 PF12802.2 ESA20052.1 - 0.00015 21.3 0.0 0.00025 20.6 0.0 1.4 1 0 0 1 1 1 1 MarR family GerE PF00196.14 ESA20052.1 - 0.0002 20.5 0.0 0.00035 19.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_32 PF13565.1 ESA20052.1 - 0.00022 21.9 0.4 0.00063 20.5 0.0 2.0 2 1 1 3 3 2 1 Homeodomain-like domain HTH_Crp_2 PF13545.1 ESA20052.1 - 0.00035 20.3 0.0 0.0069 16.1 0.0 2.2 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_6 PF01418.12 ESA20052.1 - 0.0021 17.7 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family HTH_38 PF13936.1 ESA20052.1 - 0.0026 17.2 0.0 0.0054 16.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.7 ESA20052.1 - 0.0029 17.1 0.0 0.009 15.6 0.0 1.8 2 0 0 2 2 1 1 HTH domain Sigma70_ECF PF07638.6 ESA20052.1 - 0.0066 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 ECF sigma factor Sigma70_r4 PF04545.11 ESA20052.1 - 0.011 15.0 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.17 ESA20052.1 - 0.013 15.3 0.0 0.046 13.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix HTH_24 PF13412.1 ESA20052.1 - 0.018 14.3 0.0 0.28 10.5 0.0 2.5 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR PF01047.17 ESA20052.1 - 0.019 14.6 0.0 0.034 13.8 0.0 1.5 1 0 0 1 1 1 0 MarR family PAX PF00292.13 ESA20052.1 - 0.019 14.6 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain HTH_28 PF13518.1 ESA20052.1 - 0.023 14.6 0.1 0.042 13.8 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF134 PF02001.11 ESA20052.1 - 0.037 13.9 0.0 4.3 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF134 HTH_31 PF13560.1 ESA20052.1 - 0.058 13.5 0.0 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain LacI PF00356.16 ESA20052.1 - 0.06 12.9 0.4 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Trp_repressor PF01371.14 ESA20052.1 - 0.069 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Trp repressor protein HTH_Tnp_Tc3_2 PF01498.13 ESA20052.1 - 0.083 12.9 0.1 0.2 11.7 0.0 1.7 2 0 0 2 2 1 0 Transposase Mec-17 PF05301.6 ESA20052.1 - 0.092 12.6 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Touch receptor neuron protein Mec-17 6PGD PF00393.14 ESA20052.1 - 0.093 11.9 0.1 0.11 11.7 0.1 1.0 1 0 0 1 1 1 0 6-phosphogluconate dehydrogenase, C-terminal domain FUR PF01475.14 ESA20052.1 - 0.097 12.5 0.0 4.4 7.2 0.0 2.2 1 1 1 2 2 2 0 Ferric uptake regulator family HHH_2 PF12826.2 ESA20053.1 - 0.16 11.8 0.3 0.89 9.4 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif 6PGD PF00393.14 ESA20054.1 - 1e-37 129.9 0.4 2.9e-36 125.2 0.3 2.0 1 1 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain Alpha-amylase PF00128.19 ESA20054.1 - 0.085 12.2 0.0 0.096 12.0 0.0 1.1 1 0 0 1 1 1 0 Alpha amylase, catalytic domain Med13_C PF06333.7 ESA20055.1 - 0.0055 15.3 1.1 0.007 14.9 0.8 1.1 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal G-patch PF01585.18 ESA20056.1 - 1.6e-17 62.9 3.4 2.7e-17 62.2 2.3 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA20056.1 - 1.3e-07 31.3 0.2 1.3e-07 31.3 0.1 1.9 2 0 0 2 2 2 1 DExH-box splicing factor binding site zf-C2H2_jaz PF12171.3 ESA20056.1 - 2.7e-06 27.3 3.5 6.2e-06 26.1 2.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA20056.1 - 5.9e-05 23.1 0.8 0.00014 21.9 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 ESA20056.1 - 0.0014 18.7 3.2 0.0022 18.0 2.2 1.3 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 ESA20056.1 - 0.026 14.4 0.6 0.045 13.6 0.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger Elf1 PF05129.8 ESA20056.1 - 0.041 13.5 0.3 0.068 12.8 0.2 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Evr1_Alr PF04777.8 ESA20056.1 - 0.046 13.6 0.3 0.065 13.1 0.2 1.3 1 0 0 1 1 1 0 Erv1 / Alr family zf-C2H2 PF00096.21 ESA20056.1 - 0.06 13.7 0.8 0.11 12.8 0.6 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-DBF PF07535.7 ESA20056.1 - 0.33 10.6 2.2 0.77 9.4 1.5 1.6 1 0 0 1 1 1 0 DBF zinc finger DUF1675 PF07897.6 ESA20057.1 - 0.68 9.7 10.8 0.85 9.4 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) BTB PF00651.26 ESA20058.1 - 2.6e-09 37.0 0.0 5.8e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20058.1 - 0.00038 20.2 0.1 0.17 11.7 0.0 3.1 2 1 1 3 3 3 2 BTB And C-terminal Kelch DUF2433 PF10360.4 ESA20059.1 - 1.6e-30 106.1 0.1 1.6e-30 106.1 0.1 3.6 3 2 1 4 4 4 1 Protein of unknown function (DUF2433) RRM_1 PF00076.17 ESA20059.1 - 2.4e-14 52.6 0.1 6.4e-14 51.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA20059.1 - 1.7e-12 47.1 0.0 8e-12 44.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA20059.1 - 6.5e-06 25.9 0.0 1.7e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GPI-anchored PF10342.4 ESA20061.1 - 4.7e-06 26.9 0.1 8.1e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Sel1 PF08238.7 ESA20063.1 - 8.3e-31 105.7 2.6 1.1e-07 32.2 0.1 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ESA20063.1 - 0.0077 16.6 0.5 3.2 8.3 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA20063.1 - 0.015 14.9 2.7 0.16 11.6 0.5 2.5 2 1 0 2 2 2 0 TPR repeat TPR_17 PF13431.1 ESA20063.1 - 0.17 12.1 3.2 3.4 8.1 0.3 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 ESA20064.1 - 1.8e-36 125.4 0.0 2e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 ESA20066.1 - 3.4e-21 75.5 0.1 3.7e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20066.1 - 2.5e-15 56.2 0.0 2.7e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20066.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA20067.1 - 2.1e-17 63.1 3.6 2.2e-09 37.6 0.1 3.2 3 1 0 3 3 3 2 Sel1 repeat TPR_11 PF13414.1 ESA20067.1 - 0.17 11.5 3.9 0.16 11.6 1.4 1.8 1 1 1 2 2 2 0 TPR repeat MIT PF04212.13 ESA20067.1 - 0.4 10.5 2.9 0.76 9.6 2.0 1.5 1 1 0 1 1 1 0 MIT (microtubule interacting and transport) domain MIR PF02815.14 ESA20068.1 - 0.0019 17.7 0.6 0.0049 16.4 0.1 1.9 1 1 1 2 2 2 1 MIR domain Ins145_P3_rec PF08709.6 ESA20068.1 - 0.017 14.1 1.1 1.8 7.5 0.1 2.9 2 1 1 3 3 3 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Methyltransf_28 PF02636.12 ESA20068.1 - 0.083 12.2 0.1 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MACPF PF01823.14 ESA20069.1 - 0.00042 20.0 0.2 0.00042 20.0 0.1 1.7 2 0 0 2 2 2 1 MAC/Perforin domain DUF3591 PF12157.3 ESA20069.1 - 0.0063 14.9 0.1 0.0092 14.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) DUF3942 PF13078.1 ESA20069.1 - 2.9 8.0 11.5 0.67 10.0 4.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3942) OPA3 PF07047.7 ESA20072.1 - 1.6e-37 128.2 1.2 1.6e-37 128.2 0.8 1.6 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) TMF_TATA_bd PF12325.3 ESA20072.1 - 2.2e-05 24.1 1.5 0.0022 17.7 1.9 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 ESA20072.1 - 0.00013 22.1 6.6 0.00026 21.2 4.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF904) TMF_DNA_bd PF12329.3 ESA20072.1 - 0.00033 20.3 5.7 0.00069 19.3 4.0 1.6 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding LURAP PF14854.1 ESA20072.1 - 0.00079 19.1 0.4 0.0013 18.4 0.3 1.3 1 0 0 1 1 1 1 Leucine rich adaptor protein ADIP PF11559.3 ESA20072.1 - 0.001 18.9 4.4 0.0018 18.2 3.1 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DivIC PF04977.10 ESA20072.1 - 0.0013 18.2 5.8 0.014 14.9 0.5 2.3 1 1 1 2 2 2 1 Septum formation initiator DUF1664 PF07889.7 ESA20072.1 - 0.0013 18.4 3.4 0.0018 18.0 1.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 ESA20072.1 - 0.0019 18.0 6.2 0.0035 17.2 4.3 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF342 PF03961.8 ESA20072.1 - 0.0046 15.4 3.9 0.005 15.2 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF342) DUF3740 PF12548.3 ESA20072.1 - 0.02 15.1 4.3 0.02 15.1 3.0 1.7 1 1 0 1 1 1 0 Sulfatase protein IncA PF04156.9 ESA20072.1 - 0.021 14.4 0.6 0.028 14.0 0.4 1.2 1 0 0 1 1 1 0 IncA protein Macoilin PF09726.4 ESA20072.1 - 0.021 13.1 3.0 0.022 13.0 2.1 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF1043 PF06295.7 ESA20072.1 - 0.022 14.4 4.6 0.015 14.8 2.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) APG6 PF04111.7 ESA20072.1 - 0.033 13.2 5.7 0.049 12.6 4.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 MMtag PF10159.4 ESA20072.1 - 0.036 14.0 0.1 0.072 13.1 0.1 1.5 1 0 0 1 1 1 0 Kinase phosphorylation protein Prefoldin PF02996.12 ESA20072.1 - 0.036 13.6 3.5 0.073 12.7 2.4 1.6 1 0 0 1 1 1 0 Prefoldin subunit Atg14 PF10186.4 ESA20072.1 - 0.042 12.7 6.1 0.061 12.2 4.0 1.6 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3373 PF11853.3 ESA20072.1 - 0.054 12.0 1.3 0.064 11.7 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Fmp27_WPPW PF10359.4 ESA20072.1 - 0.078 11.3 8.6 0.097 11.0 6.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GreA_GreB_N PF03449.10 ESA20072.1 - 0.085 12.9 3.2 0.3 11.1 0.4 2.4 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal PilJ PF13675.1 ESA20072.1 - 0.096 13.0 0.4 0.29 11.4 0.2 1.7 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DivIVA PF05103.8 ESA20072.1 - 0.13 12.2 5.6 0.29 11.1 3.9 1.6 1 1 0 1 1 1 0 DivIVA protein Allexi_40kDa PF05549.6 ESA20072.1 - 0.17 11.1 2.5 0.17 11.1 1.2 1.4 2 0 0 2 2 2 0 Allexivirus 40kDa protein bZIP_1 PF00170.16 ESA20072.1 - 0.24 11.3 4.7 0.73 9.8 3.3 1.9 1 1 0 1 1 1 0 bZIP transcription factor DUF972 PF06156.8 ESA20072.1 - 0.33 11.2 5.6 0.65 10.3 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 ESA20072.1 - 0.43 11.3 8.5 4 8.2 4.7 2.4 2 1 0 2 2 2 0 Occludin homology domain EMP24_GP25L PF01105.19 ESA20072.1 - 0.75 9.4 4.0 1.2 8.8 2.8 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SseC PF04888.7 ESA20072.1 - 0.8 8.9 3.6 0.91 8.7 1.9 1.5 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Snapin_Pallidin PF14712.1 ESA20072.1 - 1.9 8.8 8.6 1.5 9.1 4.2 2.1 2 1 0 2 2 2 0 Snapin/Pallidin HALZ PF02183.13 ESA20072.1 - 1.9 8.2 7.6 1.3 8.7 1.5 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper Mcp5_PH PF12814.2 ESA20073.1 - 2.3e-39 134.0 0.1 6.3e-39 132.6 0.1 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology ATG16 PF08614.6 ESA20073.1 - 0.0078 16.0 12.1 0.0078 16.0 8.4 5.9 4 1 2 6 6 6 1 Autophagy protein 16 (ATG16) RcsC PF09456.5 ESA20074.1 - 0.021 14.4 1.0 0.024 14.2 0.1 1.5 2 0 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) ELYS PF13934.1 ESA20074.1 - 0.034 13.8 0.3 0.04 13.6 0.2 1.2 1 0 0 1 1 1 0 Nuclear pore complex assembly CheZ PF04344.8 ESA20074.1 - 0.055 13.1 0.7 0.069 12.8 0.5 1.1 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ SF3b1 PF08920.5 ESA20076.1 - 4.6e-36 124.0 13.5 6.2e-35 120.3 0.8 2.6 1 1 1 2 2 2 2 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 ESA20076.1 - 5.9e-15 55.3 1.6 0.011 15.9 0.0 7.7 5 3 4 9 9 9 5 HEAT repeats HEAT PF02985.17 ESA20076.1 - 1.9e-12 46.1 9.6 0.048 13.7 0.1 9.9 11 0 0 11 11 11 3 HEAT repeat HEAT_EZ PF13513.1 ESA20076.1 - 1.1e-10 41.6 1.1 1.4 9.5 0.1 7.8 7 2 2 9 9 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.2 ESA20076.1 - 1.6e-05 25.1 1.4 0.49 10.8 0.0 4.3 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 ESA20076.1 - 0.0009 17.6 3.1 0.91 7.7 0.0 3.3 2 1 0 3 3 3 2 Adaptin N terminal region U3snoRNP10 PF12397.3 ESA20076.1 - 0.002 18.0 0.2 0.46 10.4 0.1 2.8 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 Arm PF00514.18 ESA20076.1 - 0.0029 17.3 1.8 29 4.6 0.0 5.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Dopey_N PF04118.9 ESA20076.1 - 0.052 12.3 1.2 0.82 8.3 0.0 3.3 2 1 2 4 4 4 0 Dopey, N-terminal Nop16 PF09420.5 ESA20077.1 - 6e-47 159.7 2.4 7e-47 159.5 1.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Ribosomal_L22 PF00237.14 ESA20078.1 - 2.1e-16 59.7 0.8 2.7e-16 59.4 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Pkinase_Tyr PF07714.12 ESA20082.1 - 2.7e-20 72.5 0.1 3.8e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20082.1 - 7.3e-17 61.3 0.1 1.1e-16 60.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA20082.1 - 1.4e-15 57.3 5.9 2.6e-07 31.0 0.1 3.7 3 1 0 3 3 3 2 Sel1 repeat TPR_16 PF13432.1 ESA20082.1 - 0.035 14.7 0.3 0.29 11.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA20082.1 - 0.17 12.3 2.5 47 4.7 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MSV199 PF10553.4 ESA20084.1 - 1.8 8.4 14.0 9 6.1 9.7 2.1 1 1 0 1 1 1 0 MSV199 domain Anemone_cytotox PF06369.7 ESA20085.1 - 2e-24 85.9 0.1 2.4e-24 85.6 0.1 1.0 1 0 0 1 1 1 1 Sea anemone cytotoxic protein DUF3923 PF13061.1 ESA20086.1 - 0.047 13.5 0.8 0.11 12.3 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3923) DUF3980 PF13140.1 ESA20086.1 - 0.82 9.9 4.7 0.43 10.8 1.7 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3980) Pkinase PF00069.20 ESA20087.1 - 9e-42 143.0 0.1 1.1e-41 142.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20087.1 - 1.1e-38 132.7 0.0 1.5e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20087.1 - 0.00027 19.9 0.0 0.038 12.9 0.0 2.1 2 0 0 2 2 2 2 Kinase-like WaaY PF06176.6 ESA20087.1 - 0.0015 17.8 0.3 0.0021 17.2 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA20087.1 - 0.0015 17.9 0.4 0.0037 16.6 0.1 1.7 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA20087.1 - 0.0069 16.1 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20087.1 - 0.014 14.4 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GFO_IDH_MocA PF01408.17 ESA20087.1 - 0.16 12.5 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ABC_membrane PF00664.18 ESA20089.1 - 4.7e-54 183.6 31.3 2.8e-36 125.3 10.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 ESA20089.1 - 1.5e-21 77.1 0.1 4.7e-21 75.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter Dynamin_N PF00350.18 ESA20089.1 - 0.0046 16.7 1.0 0.0046 16.7 0.7 3.2 3 0 0 3 3 3 1 Dynamin family Miro PF08477.8 ESA20089.1 - 0.0085 16.5 0.3 0.0085 16.5 0.2 2.1 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 ESA20089.1 - 0.011 15.7 0.2 0.048 13.6 0.2 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA20089.1 - 0.021 14.8 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 ESA20089.1 - 0.022 13.9 0.4 0.05 12.7 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA20089.1 - 0.03 13.8 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 ESA20089.1 - 0.062 12.7 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 ESA20089.1 - 9.2 5.1 12.5 6.8 5.6 1.6 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 F-box-like PF12937.2 ESA20090.1 - 3.1e-06 26.8 0.1 8.4e-06 25.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like Amino_oxidase PF01593.19 ESA20091.1 - 7e-27 94.5 0.0 9.7e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 ESA20091.1 - 5.2e-13 48.8 0.1 1.5e-12 47.3 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 ESA20091.1 - 1.3e-08 34.2 0.0 7.9e-06 25.0 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 ESA20091.1 - 0.00044 20.6 0.3 0.69 10.3 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 ESA20091.1 - 0.0021 17.1 0.0 0.0041 16.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 ESA20091.1 - 0.0032 17.3 0.1 0.44 10.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA20091.1 - 0.018 14.8 0.1 0.36 10.5 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 ESA20091.1 - 0.037 12.6 0.0 0.059 11.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase HI0933_like PF03486.9 ESA20091.1 - 0.07 11.5 0.0 3.5 5.9 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein Acyl-thio_N PF12590.3 ESA20091.1 - 0.078 13.4 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Acyl-ATP thioesterase WAC_Acf1_DNA_bd PF10537.4 ESA20092.1 - 1.9e-31 108.2 0.6 7.1e-31 106.3 0.4 2.1 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 ESA20092.1 - 1.1e-10 41.1 0.4 5.9e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 DDT domain WHIM2 PF15613.1 ESA20092.1 - 0.00073 19.3 0.1 0.002 18.0 0.0 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 DUF4192 PF13830.1 ESA20092.1 - 4.1 6.9 7.0 77 2.7 4.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4192) UPF0086 PF01868.11 ESA20094.1 - 0.053 13.1 0.5 2 8.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function UPF0086 NurA PF09376.5 ESA20094.1 - 0.098 12.1 0.2 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 NurA domain Gp_UL130 PF11668.3 ESA20095.1 - 0.053 13.0 0.0 0.062 12.8 0.0 1.1 1 0 0 1 1 1 0 HCMV glycoprotein pUL130 PyrI_C PF02748.10 ESA20097.1 - 0.078 12.4 0.5 0.12 11.8 0.4 1.2 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.4 ESA20097.1 - 0.15 11.8 0.6 0.26 11.1 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger domain OAR PF03826.12 ESA20099.1 - 0.019 14.5 3.5 0.019 14.5 2.4 2.0 2 0 0 2 2 2 0 OAR domain PXB PF12828.2 ESA20099.1 - 0.022 14.3 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 PX-associated DUF912 PF06024.7 ESA20103.1 - 0.12 12.4 0.7 0.3 11.1 0.5 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) zf-CCHC PF00098.18 ESA20105.1 - 3.6e-07 29.7 0.4 5.6e-07 29.1 0.3 1.3 1 0 0 1 1 1 1 Zinc knuckle DUF2718 PF10918.3 ESA20106.1 - 0.27 11.3 4.3 0.33 11.0 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) GCP5-Mod21 PF14609.1 ESA20106.1 - 0.46 8.5 5.8 0.47 8.5 4.0 1.0 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 Dimer_Tnp_hAT PF05699.9 ESA20107.1 - 9.7e-07 28.3 0.1 1.8e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DDE_3 PF13358.1 ESA20108.1 - 0.00014 21.6 0.0 0.00024 20.8 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease Aconitase PF00330.15 ESA20109.1 - 3.2e-176 586.3 0.0 9.2e-176 584.8 0.0 1.7 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 ESA20109.1 - 1.6e-46 157.6 0.0 3.6e-46 156.5 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain HECT PF00632.20 ESA20110.1 - 4.8e-09 35.8 0.1 5.6e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF1273 PF06908.6 ESA20110.1 - 0.021 14.5 0.8 0.042 13.5 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1273) Colicin-DNase PF12639.2 ESA20110.1 - 0.1 12.8 0.2 0.39 10.9 0.1 2.0 1 1 0 1 1 1 0 DNase/tRNase domain of colicin-like bacteriocin NOB1_Zn_bind PF08772.6 ESA20111.1 - 0.0069 16.1 0.2 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Imm22 PF15592.1 ESA20113.1 - 0.0019 18.5 0.2 0.0026 18.0 0.1 1.2 1 1 0 1 1 1 1 Immunity protein 22 DUF4375 PF14300.1 ESA20113.1 - 0.0059 16.5 0.9 0.0069 16.3 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4375) DUF4093 PF13331.1 ESA20113.1 - 0.024 14.8 0.5 0.028 14.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) DUF3829 PF12889.2 ESA20113.1 - 0.046 12.9 1.6 0.049 12.8 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Chordopox_L2 PF05803.7 ESA20113.1 - 0.1 12.2 0.7 0.17 11.5 0.5 1.3 1 0 0 1 1 1 0 Chordopoxvirus L2 protein LRR_4 PF12799.2 ESA20113.1 - 0.14 11.8 0.2 0.31 10.7 0.1 1.7 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) DUF2852 PF11014.3 ESA20113.1 - 0.29 11.1 1.9 0.55 10.2 1.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) ATP-synt_E_2 PF08112.6 ESA20113.1 - 0.75 9.9 6.4 1.7 8.7 4.4 1.6 1 1 0 1 1 1 0 ATP synthase epsilon subunit DBD_Tnp_Mut PF03108.10 ESA20116.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 MuDR family transposase CagY_M PF07337.6 ESA20117.1 - 0.023 14.1 0.1 62 3.1 0.0 3.9 3 0 0 3 3 3 0 DC-EC Repeat Effector_1 PF04518.7 ESA20117.1 - 0.1 11.5 1.2 0.13 11.2 0.8 1.1 1 0 0 1 1 1 0 Effector from type III secretion system BTB PF00651.26 ESA20118.1 - 7.1e-10 38.8 0.1 1.2e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20118.1 - 4e-07 29.8 0.9 4.7e-05 23.1 0.0 3.0 2 1 1 3 3 3 2 BTB And C-terminal Kelch DUF1366 PF07104.6 ESA20118.1 - 0.086 12.4 0.5 0.29 10.7 0.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1366) p450 PF00067.17 ESA20120.1 - 1.1e-07 30.8 0.0 1.2e-07 30.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SAM_1 PF00536.25 ESA20123.1 - 0.0041 17.2 0.0 0.013 15.6 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ebola_NP PF05505.7 ESA20127.1 - 0.13 10.2 1.9 0.14 10.2 1.3 1.0 1 0 0 1 1 1 0 Ebola nucleoprotein DUF4131 PF13567.1 ESA20128.1 - 0.055 12.8 6.3 0.17 11.2 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF373 PF04123.8 ESA20128.1 - 0.1 11.5 6.9 0.39 9.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF373) MNHE PF01899.11 ESA20128.1 - 0.24 11.0 7.9 0.33 10.5 0.5 2.4 1 1 1 2 2 2 0 Na+/H+ ion antiporter subunit GOLD_2 PF13897.1 ESA20129.1 - 4.4e-07 30.1 0.8 0.037 14.2 0.0 2.7 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking Oxysterol_BP PF01237.13 ESA20130.1 - 7.8e-119 396.2 0.8 1.1e-118 395.7 0.6 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.1 ESA20130.1 - 1.4e-11 44.3 0.0 3.8e-11 42.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain KAR9 PF08580.5 ESA20131.1 - 1.6e-11 43.2 36.5 7.1e-11 41.1 25.3 1.8 1 1 0 1 1 1 1 Yeast cortical protein KAR9 GAS2 PF02187.12 ESA20131.1 - 5.5e-07 29.2 0.0 1.2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Mnd1 PF03962.10 ESA20131.1 - 0.37 10.4 12.3 0.14 11.8 0.6 3.1 2 1 1 3 3 3 0 Mnd1 family DUF4200 PF13863.1 ESA20131.1 - 3.9 7.4 13.7 2.1 8.3 1.4 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Uds1 PF15456.1 ESA20131.1 - 9.3 6.2 11.6 4.6 7.2 2.2 3.4 2 1 1 3 3 3 0 Up-regulated During Septation RNA_pol_Rpb2_6 PF00562.23 ESA20132.1 - 1.6e-130 435.3 0.4 3.8e-130 434.1 0.3 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 ESA20132.1 - 3.6e-69 231.7 0.0 5.5e-69 231.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 ESA20132.1 - 7.6e-43 146.1 0.0 1.7e-42 144.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 ESA20132.1 - 1.3e-31 108.6 0.0 3.9e-31 107.1 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 ESA20132.1 - 3.2e-25 87.7 0.1 7.6e-25 86.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 ESA20132.1 - 3.5e-23 81.1 0.1 7.5e-23 80.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 ESA20132.1 - 1.2e-19 69.9 1.7 3.3e-19 68.5 1.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L30 PF00327.15 ESA20133.1 - 6.4e-14 51.2 0.9 8e-14 50.9 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Chordopox_A30L PF06015.7 ESA20133.1 - 0.0078 15.7 0.2 0.009 15.6 0.1 1.1 1 0 0 1 1 1 1 Chordopoxvirus A30L protein ATP-grasp_2 PF08442.5 ESA20134.1 - 6.6e-76 254.1 0.3 9.7e-76 253.6 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 ESA20134.1 - 3.7e-28 98.0 1.5 6.4e-28 97.2 1.0 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.1 ESA20134.1 - 1.2e-09 37.7 0.4 3e-09 36.4 0.3 1.7 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 ESA20134.1 - 0.00025 20.6 0.5 0.0012 18.4 0.0 2.3 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.6 ESA20134.1 - 0.0032 16.9 0.1 0.036 13.5 0.0 2.6 2 1 1 3 3 3 1 RimK-like ATP-grasp domain HipA_N PF07805.7 ESA20134.1 - 0.017 15.2 0.0 0.12 12.6 0.0 2.4 3 0 0 3 3 3 0 HipA-like N-terminal domain Succ_CoA_lig PF13607.1 ESA20134.1 - 0.04 13.5 0.4 2.9 7.5 0.1 2.4 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain SR-25 PF10500.4 ESA20135.1 - 1e-32 113.4 57.3 1e-32 113.4 39.7 1.8 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein CDC27 PF09507.5 ESA20135.1 - 0.0029 16.8 30.9 0.0034 16.6 21.4 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 V_ATPase_I PF01496.14 ESA20135.1 - 0.094 10.5 12.0 0.1 10.4 8.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Corona_nucleoca PF00937.13 ESA20135.1 - 1.4 7.8 39.6 0.28 10.0 24.9 1.7 1 1 1 2 2 2 0 Coronavirus nucleocapsid protein SOBP PF15279.1 ESA20135.1 - 2.2 8.6 22.0 2.6 8.3 15.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein MIP-T3 PF10243.4 ESA20135.1 - 3.3 6.0 41.7 4.2 5.7 28.9 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Peptidase_S64 PF08192.6 ESA20135.1 - 7.8 4.6 19.5 8.9 4.4 13.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Lyase_1 PF00206.15 ESA20137.1 - 1.3e-22 80.3 0.0 2.4e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 ESA20137.1 - 2.8e-09 36.8 0.0 6.8e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Collagen PF01391.13 ESA20139.1 - 0.038 13.5 1.3 0.057 12.9 0.9 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) KH_1 PF00013.24 ESA20145.1 - 4.2e-07 29.5 2.7 8.9e-07 28.4 1.9 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 ESA20145.1 - 1.3e-05 24.7 1.1 2.8e-05 23.6 0.8 1.6 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 ESA20145.1 - 0.098 12.3 1.9 0.32 10.6 0.5 2.5 1 1 2 3 3 3 0 KH domain TLD PF07534.11 ESA20147.1 - 1.2e-12 48.0 2.6 1.2e-12 48.0 1.8 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20147.1 - 4.4e-07 29.6 0.7 1.4e-06 28.0 0.0 2.2 3 0 0 3 3 3 1 BTB And C-terminal Kelch Cupin_4 PF08007.7 ESA20147.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein Pkinase_Tyr PF07714.12 ESA20149.1 - 4.9e-09 35.6 0.0 5.6e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20149.1 - 0.00044 19.4 0.0 0.00053 19.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain AAA_21 PF13304.1 ESA20150.1 - 0.0058 16.6 2.9 0.0085 16.0 2.0 1.3 1 1 0 1 1 1 1 AAA domain PUF PF00806.14 ESA20152.1 - 6.5e-63 204.8 12.4 1.2e-08 33.9 0.1 7.2 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat Utp13 PF08625.6 ESA20152.1 - 0.0055 16.3 1.8 0.022 14.3 0.2 2.6 1 1 1 3 3 3 1 Utp13 specific WD40 associated domain DUF3244 PF11589.3 ESA20152.1 - 0.0074 15.9 0.1 0.083 12.6 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF3244) DUF260 PF03195.9 ESA20152.1 - 0.073 13.3 0.7 21 5.4 0.0 3.4 2 2 2 4 4 4 0 Protein of unknown function DUF260 DUF445 PF04286.7 ESA20152.1 - 0.08 12.4 1.8 0.78 9.2 1.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Tenui_NCP PF04876.7 ESA20152.1 - 0.13 11.8 1.5 0.76 9.2 0.1 2.7 2 1 1 3 3 3 0 Tenuivirus major non-capsid protein NABP PF07990.7 ESA20152.1 - 0.19 10.9 0.7 0.31 10.2 0.5 1.4 1 0 0 1 1 1 0 Nucleic acid binding protein NABP Membr_traf_MHD PF10540.4 ESA20152.1 - 0.49 10.1 3.8 6.7 6.5 0.1 2.8 1 1 1 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain BTB PF00651.26 ESA20154.1 - 1.6e-23 82.8 0.1 2.5e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20154.1 - 4e-08 33.0 5.8 7.7e-05 22.4 0.4 4.2 3 1 1 4 4 4 2 BTB And C-terminal Kelch Brix PF04427.13 ESA20154.1 - 0.011 15.3 0.7 0.19 11.3 0.1 2.2 2 0 0 2 2 2 0 Brix domain BNIP2 PF12496.3 ESA20156.1 - 0.3 11.2 2.2 0.69 10.0 1.5 1.5 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 SAM_2 PF07647.12 ESA20157.1 - 0.0008 19.2 0.4 0.0016 18.2 0.2 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 ESA20157.1 - 0.0014 18.7 0.1 0.0033 17.5 0.1 1.7 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) S_layer_C PF05124.7 ESA20158.1 - 0.024 14.2 6.6 0.027 14.0 4.6 1.2 1 0 0 1 1 1 0 S-layer like family, C-terminal region ABC2_membrane_3 PF12698.2 ESA20158.1 - 9.6 5.1 9.9 11 4.9 6.9 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Pkinase PF00069.20 ESA20159.1 - 5.7e-43 146.9 0.0 6.2e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20159.1 - 1.3e-22 80.1 0.0 1.4e-22 79.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20159.1 - 0.00055 18.9 0.0 0.00085 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA20159.1 - 0.0032 17.2 0.0 0.0047 16.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20159.1 - 0.071 12.1 0.1 0.11 11.5 0.0 1.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 ESA20159.1 - 0.12 11.1 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 YlqD PF11068.3 ESA20160.1 - 0.0078 16.2 7.8 0.0078 16.2 5.4 2.1 2 0 0 2 2 2 1 YlqD protein DUF342 PF03961.8 ESA20160.1 - 0.019 13.3 17.1 0.057 11.8 5.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) MitMem_reg PF13012.1 ESA20160.1 - 0.08 13.0 6.1 1.2 9.2 0.0 2.9 1 1 2 3 3 3 0 Maintenance of mitochondrial structure and function Apolipoprotein PF01442.13 ESA20160.1 - 0.09 12.2 6.8 0.2 11.1 4.0 1.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Endotoxin_N PF03945.9 ESA20160.1 - 0.14 11.5 5.3 0.032 13.6 0.8 1.8 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain DUF349 PF03993.7 ESA20160.1 - 0.21 11.7 0.2 0.21 11.7 0.1 2.7 2 1 0 2 2 1 0 Domain of Unknown Function (DUF349) OmpH PF03938.9 ESA20160.1 - 0.28 11.1 6.8 0.039 13.8 0.9 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ASD2 PF08687.6 ESA20160.1 - 0.32 10.2 11.1 0.17 11.1 5.0 2.2 2 1 0 2 2 2 0 Apx/Shroom domain ASD2 ApoLp-III PF07464.6 ESA20160.1 - 0.34 10.9 10.0 0.25 11.3 3.6 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Cor1 PF04803.7 ESA20160.1 - 0.43 10.3 18.2 2.6 7.8 7.2 2.4 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Phage_lysis PF03245.8 ESA20160.1 - 0.57 10.1 4.4 0.55 10.2 2.0 1.6 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein GAS PF13851.1 ESA20160.1 - 0.73 8.9 25.7 0.2 10.8 9.9 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESA20160.1 - 0.87 9.1 12.0 0.052 13.1 3.5 2.1 2 0 0 2 2 2 0 IncA protein DUF4404 PF14357.1 ESA20160.1 - 1 9.8 6.1 0.61 10.5 2.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) V_ATPase_I PF01496.14 ESA20160.1 - 2.7 5.7 14.7 0.12 10.1 5.6 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4337 PF14235.1 ESA20160.1 - 3.4 7.4 10.6 0.27 11.0 3.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) APG6 PF04111.7 ESA20160.1 - 4.7 6.1 19.0 0.35 9.8 7.6 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 Telomere_reg-2 PF10193.4 ESA20160.1 - 5.5 7.2 6.9 3.3 8.0 0.1 2.8 2 2 0 2 2 2 0 Telomere length regulation protein BAG PF02179.11 ESA20160.1 - 6.3 6.9 15.9 0.26 11.4 0.3 3.1 2 2 1 3 3 3 0 BAG domain MAD PF05557.8 ESA20160.1 - 6.8 4.6 21.5 0.69 7.9 9.4 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein DUF4482 PF14818.1 ESA20160.1 - 9.1 6.9 19.9 1.2 9.8 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4482) Prefoldin PF02996.12 ESA20160.1 - 9.3 5.9 16.3 5.5 6.6 2.1 3.5 3 1 1 4 4 3 0 Prefoldin subunit AAA_11 PF13086.1 ESA20160.1 - 9.8 5.6 10.2 23 4.4 7.1 1.7 1 1 1 2 2 2 0 AAA domain Trp_halogenase PF04820.9 ESA20162.1 - 2.6e-06 26.3 0.1 2.9e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 Tryptophan halogenase DAO PF01266.19 ESA20162.1 - 1.4e-05 24.2 0.3 1.9e-05 23.7 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 ESA20162.1 - 0.0045 16.8 0.1 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA20162.1 - 0.0089 16.0 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 ESA20162.1 - 0.015 14.1 0.7 0.021 13.7 0.5 1.1 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.17 ESA20162.1 - 0.027 13.3 0.1 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 ESA20162.1 - 0.16 11.0 0.2 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase Phg_2220_C PF09524.5 ESA20164.1 - 0.091 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) LRR_4 PF12799.2 ESA20165.1 - 8.9e-11 41.1 14.2 0.00066 19.2 0.4 4.5 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA20165.1 - 0.0049 16.5 11.2 0.12 12.1 1.8 3.7 1 1 3 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ESA20165.1 - 0.0057 16.5 13.2 2.9 8.2 0.4 6.4 3 2 2 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 ESA20165.1 - 0.034 14.2 11.0 21 5.9 1.2 6.3 4 3 0 4 4 4 0 Leucine rich repeat LRR_6 PF13516.1 ESA20165.1 - 0.26 11.4 10.5 39 4.7 2.1 5.6 4 2 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.2 ESA20166.1 - 1.7e-10 40.2 20.6 0.0024 17.4 0.1 4.8 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA20166.1 - 2.4e-08 33.6 16.2 0.0037 16.9 1.5 4.2 2 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 ESA20166.1 - 0.0013 18.5 20.6 2.8 8.3 0.3 6.8 3 1 3 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA20166.1 - 0.018 15.1 15.3 10 6.8 0.5 6.6 4 2 2 6 6 6 0 Leucine rich repeat Pentapeptide_4 PF13599.1 ESA20166.1 - 0.022 14.5 4.0 0.067 13.0 2.4 2.1 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) LRR_6 PF13516.1 ESA20166.1 - 0.052 13.6 16.1 10 6.5 0.1 6.8 4 1 3 7 7 7 0 Leucine Rich repeat Pkinase_Tyr PF07714.12 ESA20168.1 - 1.5e-06 27.4 0.0 1.6e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20168.1 - 0.015 14.4 0.0 0.015 14.4 0.0 1.0 1 0 0 1 1 1 0 Protein kinase domain BTB PF00651.26 ESA20169.1 - 3.7e-07 30.1 0.0 4.3e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain ArsR PF09824.4 ESA20170.1 - 0.053 12.8 0.3 0.12 11.6 0.2 1.5 1 1 1 2 2 2 0 ArsR transcriptional regulator RCC1 PF00415.13 ESA20173.1 - 1.1e-41 140.8 6.0 9.9e-17 60.8 0.1 4.4 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 ESA20173.1 - 5.6e-27 92.7 11.6 1.5e-09 37.2 0.3 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.1 ESA20173.1 - 0.13 12.0 1.7 43 3.9 0.3 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain CTP_transf_1 PF01148.15 ESA20174.1 - 7.4e-10 38.9 14.4 7.8e-09 35.5 10.0 2.1 1 1 0 1 1 1 1 Cytidylyltransferase family Nucleopor_Nup85 PF07575.8 ESA20175.1 - 2.3e-82 277.0 7.4 3e-82 276.6 5.2 1.1 1 0 0 1 1 1 1 Nup85 Nucleoporin HSP70 PF00012.15 ESA20176.1 - 1.4e-62 211.4 2.5 1.6e-62 211.3 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF1843 PF08898.5 ESA20176.1 - 0.15 12.1 0.3 0.15 12.1 0.2 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1843) YolD PF08863.5 ESA20176.1 - 0.36 10.7 5.6 1.1 9.1 0.3 3.0 2 1 1 3 3 3 0 YolD-like protein HSP70 PF00012.15 ESA20177.1 - 2.2e-32 111.7 0.1 2.5e-32 111.6 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein GspH PF12019.3 ESA20177.1 - 0.075 13.1 0.1 0.087 12.9 0.1 1.1 1 0 0 1 1 1 0 Type II transport protein GspH DUF3858 PF12970.2 ESA20178.1 - 0.028 14.1 0.0 0.028 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3858) Rad60-SLD_2 PF13881.1 ESA20179.1 - 0.047 13.5 0.1 0.093 12.6 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like GRASP55_65 PF04495.9 ESA20179.1 - 0.1 12.5 0.1 0.55 10.2 0.0 2.0 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain Sel1 PF08238.7 ESA20180.1 - 2.3e-27 94.7 3.6 1.9e-10 41.0 0.2 4.0 4 0 0 4 4 4 4 Sel1 repeat DUF2768 PF10966.3 ESA20181.1 - 0.091 12.9 1.7 0.16 12.1 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) DUF3279 PF11682.3 ESA20183.1 - 0.016 14.7 1.8 0.072 12.6 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3279) ImpE PF07024.8 ESA20183.1 - 0.12 12.3 0.2 15 5.5 0.0 3.5 4 0 0 4 4 4 0 ImpE protein MCR_gamma PF02240.11 ESA20184.1 - 0.1 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit AA_kinase PF00696.23 ESA20185.1 - 6.8e-43 146.9 0.3 1.2e-42 146.1 0.1 1.5 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.20 ESA20185.1 - 3.7e-17 61.4 1.9 3.9e-10 39.0 0.1 3.0 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.1 ESA20185.1 - 1e-12 47.3 6.0 1e-10 40.9 0.3 3.0 3 0 0 3 3 3 2 ACT domain DUF4618 PF15397.1 ESA20186.1 - 0.12 11.6 0.2 0.14 11.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DivIC PF04977.10 ESA20188.1 - 0.0023 17.3 3.9 0.003 17.0 2.7 1.3 1 0 0 1 1 1 1 Septum formation initiator Nnf1 PF03980.9 ESA20188.1 - 0.032 14.2 0.8 0.046 13.7 0.6 1.2 1 0 0 1 1 1 0 Nnf1 DUF904 PF06005.7 ESA20188.1 - 0.095 13.0 4.1 0.15 12.3 2.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF4015 PF13200.1 ESA20188.1 - 0.11 11.4 0.4 0.1 11.4 0.3 1.0 1 0 0 1 1 1 0 Putative glycosyl hydrolase domain Vma12 PF11712.3 ESA20188.1 - 0.14 11.8 0.8 0.14 11.8 0.6 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1875 PF08961.5 ESA20188.1 - 0.15 11.3 1.6 0.16 11.2 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1875) DUF3373 PF11853.3 ESA20188.1 - 0.41 9.1 2.8 0.42 9.0 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Gemini_AL1_M PF08283.6 ESA20190.1 - 0.0037 17.0 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Geminivirus rep protein central domain SDA1 PF05285.7 ESA20191.1 - 0.0022 17.3 20.0 0.0025 17.1 13.9 1.1 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.9 ESA20191.1 - 0.049 11.6 14.5 0.06 11.3 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein TLP-20 PF06088.6 ESA20191.1 - 0.12 12.0 12.0 0.21 11.2 8.3 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) TRAP_alpha PF03896.11 ESA20191.1 - 0.23 10.4 10.0 0.32 9.9 6.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Caldesmon PF02029.10 ESA20191.1 - 0.48 8.7 23.4 0.58 8.5 16.2 1.2 1 0 0 1 1 1 0 Caldesmon DUF3451 PF11933.3 ESA20191.1 - 0.58 9.9 9.7 0.79 9.4 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3451) Hus1 PF04005.7 ESA20191.1 - 0.86 8.4 14.8 2.3 7.0 10.3 1.6 1 1 0 1 1 1 0 Hus1-like protein Nucleoside_tran PF01733.13 ESA20191.1 - 0.95 8.5 3.4 1.6 7.8 2.3 1.4 1 0 0 1 1 1 0 Nucleoside transporter Astro_capsid PF03115.9 ESA20191.1 - 2.1 6.5 8.9 2.2 6.4 6.2 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor SID-1_RNA_chan PF13965.1 ESA20191.1 - 5 5.1 7.0 5.7 4.9 4.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EST1 PF10374.4 ESA20191.1 - 8.7 6.3 11.0 10 6.1 4.7 2.8 1 1 2 3 3 3 0 Telomerase activating protein Est1 TEX19 PF15553.1 ESA20191.1 - 9.2 6.1 9.2 18 5.1 6.4 1.5 1 0 0 1 1 1 0 Testis-expressed protein 19 Fer2_4 PF13510.1 ESA20193.1 - 0.072 12.9 0.0 0.086 12.6 0.0 1.1 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Pkinase_Tyr PF07714.12 ESA20194.1 - 2.5e-33 115.2 0.0 2.8e-33 115.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20194.1 - 4.8e-32 111.1 0.0 6.2e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA20194.1 - 0.033 13.2 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family IncA PF04156.9 ESA20195.1 - 0.096 12.2 10.2 0.14 11.7 7.1 1.2 1 0 0 1 1 1 0 IncA protein DUF3201 PF11447.3 ESA20195.1 - 0.23 10.8 7.4 1.1 8.6 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3201) BTB PF00651.26 ESA20196.1 - 1.5e-14 53.9 0.0 3.5e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20196.1 - 7e-11 42.2 1.8 4.7e-10 39.6 0.3 2.4 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20196.1 - 1.2e-09 37.8 6.7 3.2e-07 30.1 0.4 4.0 3 1 1 4 4 4 2 BTB And C-terminal Kelch Urm1 PF09138.6 ESA20196.1 - 0.058 13.5 0.1 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Urm1 (Ubiquitin related modifier) HPD PF05044.7 ESA20197.1 - 0.48 10.0 2.6 2.2 7.9 0.2 2.3 1 1 0 2 2 2 0 Homeo-prospero domain PDH PF02153.12 ESA20198.1 - 0.025 13.4 0.4 0.041 12.7 0.3 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase BTB PF00651.26 ESA20200.1 - 1.1e-06 28.5 0.1 1.4e-06 28.2 0.1 1.2 1 1 0 1 1 1 1 BTB/POZ domain Tctex-1 PF03645.8 ESA20200.1 - 0.096 12.5 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Tctex-1 family Cas_NE0113 PF09623.5 ESA20201.1 - 0.15 11.4 0.2 0.18 11.2 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) CLASP_N PF12348.3 ESA20202.1 - 2.8e-09 36.6 0.2 8.1e-07 28.6 0.1 3.0 3 0 0 3 3 3 1 CLASP N terminal HEAT PF02985.17 ESA20202.1 - 5.5e-06 26.0 0.0 1.6 8.9 0.0 5.7 7 0 0 7 7 7 2 HEAT repeat Ribosomal_60s PF00428.14 ESA20202.1 - 0.0018 18.6 23.1 0.038 14.3 3.1 3.4 3 1 0 3 3 3 2 60s Acidic ribosomal protein Vac14_Fab1_bd PF12755.2 ESA20202.1 - 0.0075 16.6 0.0 5.4 7.4 0.0 3.8 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region TAN PF11640.3 ESA20202.1 - 0.0087 15.8 0.3 0.17 11.6 0.0 2.9 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair Pkinase_Tyr PF07714.12 ESA20203.1 - 4e-47 160.4 0.0 6.2e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20203.1 - 3.6e-46 157.4 0.1 8.8e-46 156.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain DUF4564 PF15169.1 ESA20203.1 - 0.17 11.5 3.1 0.37 10.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4564) F-box-like PF12937.2 ESA20204.1 - 0.00079 19.0 0.2 0.0034 17.0 0.1 2.1 1 0 0 1 1 1 1 F-box-like ThiF PF00899.16 ESA20205.1 - 0.039 13.7 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 ThiF family HlyD_2 PF12700.2 ESA20205.1 - 0.11 11.6 1.9 0.12 11.5 1.3 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Mating_C PF12737.2 ESA20205.1 - 3.7 6.3 8.7 3.3 6.5 4.9 1.6 1 1 1 2 2 2 0 C-terminal domain of homeodomain 1 DUF463 PF04317.7 ESA20206.1 - 0.026 13.1 0.2 0.029 12.9 0.1 1.0 1 0 0 1 1 1 0 YcjX-like family, DUF463 DUF3557 PF12078.3 ESA20210.1 - 0.15 11.7 1.6 0.88 9.2 0.2 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3557) Corona_7 PF02398.11 ESA20211.1 - 3.7 8.0 6.9 4.4 7.8 0.1 2.9 3 0 0 3 3 3 0 Coronavirus protein 7 MreB_Mbl PF06723.8 ESA20214.1 - 0.0013 17.3 0.0 0.15 10.6 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Myosin_tail_1 PF01576.14 ESA20214.1 - 0.0052 14.5 24.4 0.0075 14.0 16.9 1.1 1 0 0 1 1 1 1 Myosin tail GspL_C PF12693.2 ESA20214.1 - 0.41 10.3 6.4 2 8.1 1.2 2.5 2 1 1 3 3 3 0 GspL periplasmic domain APG6 PF04111.7 ESA20214.1 - 1.6 7.6 27.6 2.8 6.9 19.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3347 PF11827.3 ESA20214.1 - 1.6 8.6 12.3 3.2 7.7 8.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF972 PF06156.8 ESA20214.1 - 1.8 8.9 27.1 5 7.5 9.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Speriolin_N PF15058.1 ESA20214.1 - 2.2 8.1 5.6 4 7.2 3.9 1.4 1 0 0 1 1 1 0 Speriolin N terminus Exonuc_VII_L PF02601.10 ESA20214.1 - 3.9 6.5 19.9 6.6 5.8 13.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.14 ESA20214.1 - 6.8 4.4 15.2 9.4 3.9 10.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ion_trans PF00520.26 ESA20215.1 - 1.4e-08 34.1 15.2 2.1e-08 33.6 10.5 1.2 1 0 0 1 1 1 1 Ion transport protein Humanin PF15040.1 ESA20215.1 - 0.35 10.1 1.9 10 5.4 0.0 2.4 2 0 0 2 2 2 0 Humanin family COX6B PF02297.12 ESA20217.1 - 4e-18 65.1 5.4 5.2e-18 64.8 3.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 ESA20217.1 - 0.013 15.5 2.7 3.1 7.9 0.6 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 PB1 PF00564.19 ESA20217.1 - 0.028 14.0 0.1 0.036 13.7 0.1 1.2 1 0 0 1 1 1 0 PB1 domain Gti1_Pac2 PF09729.4 ESA20218.1 - 1.5e-37 129.0 2.4 2e-35 122.1 0.7 2.6 2 1 0 2 2 2 1 Gti1/Pac2 family DSHCT PF08148.7 ESA20219.1 - 3.8e-54 182.6 0.2 7.9e-29 100.1 0.0 2.6 2 0 0 2 2 2 2 DSHCT (NUC185) domain DEAD PF00270.24 ESA20219.1 - 1.1e-19 70.5 0.1 2.5e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.1 ESA20219.1 - 1.6e-08 34.0 2.6 3.3e-08 33.0 1.8 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.26 ESA20219.1 - 4.1e-06 26.5 0.0 1.5e-05 24.7 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CbiG_C PF01890.11 ESA20219.1 - 0.22 11.7 0.3 4.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Cobalamin synthesis G C-terminus DUF2042 PF09743.4 ESA20220.1 - 0.061 12.6 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2042) SAM_1 PF00536.25 ESA20220.1 - 0.083 13.0 0.1 1.7 8.9 0.0 2.5 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) CoaE PF01121.15 ESA20221.1 - 0.037 13.4 0.1 0.065 12.6 0.1 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase Pkinase_Tyr PF07714.12 ESA20222.1 - 5.5e-09 35.4 0.0 8.5e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20222.1 - 0.00027 20.1 0.0 0.00045 19.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Eaf7 PF07904.8 ESA20224.1 - 0.33 10.9 2.2 2.2 8.3 0.0 2.3 1 1 0 2 2 2 0 Chromatin modification-related protein EAF7 MAP PF03642.8 ESA20224.1 - 1.3 9.2 8.8 3.5 7.9 3.6 2.4 1 1 1 2 2 2 0 MAP domain AF1Q PF15017.1 ESA20226.1 - 0.041 13.7 1.3 0.041 13.7 0.9 1.5 2 0 0 2 2 2 0 Drug resistance and apoptosis regulator Apis_Csd PF11671.3 ESA20226.1 - 0.22 11.3 1.6 0.29 10.9 1.1 1.4 1 1 0 1 1 1 0 Complementary sex determiner protein RRM_6 PF14259.1 ESA20227.1 - 0.0003 20.7 0.0 0.00063 19.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA20227.1 - 0.0047 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sel1 PF08238.7 ESA20228.1 - 5.8e-34 115.7 15.1 5.5e-09 36.3 0.7 5.1 5 0 0 5 5 5 4 Sel1 repeat NSF PF02071.15 ESA20228.1 - 0.7 10.6 9.9 16 6.6 0.2 4.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_17 PF13431.1 ESA20228.1 - 1.5 9.2 15.7 20 5.6 0.6 5.4 3 2 2 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA20228.1 - 2.8 7.9 12.6 8.5 6.3 0.2 4.0 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA20228.1 - 9 6.0 17.4 3.5 7.3 5.1 3.6 2 1 2 4 4 4 0 TPR repeat ISK_Channel PF02060.10 ESA20234.1 - 0.038 13.5 0.2 0.048 13.2 0.2 1.1 1 0 0 1 1 1 0 Slow voltage-gated potassium channel TLD PF07534.11 ESA20235.1 - 0.0041 17.1 0.2 0.0061 16.5 0.2 1.4 1 1 0 1 1 1 1 TLD Mito_carr PF00153.22 ESA20236.1 - 6.1e-23 80.3 0.0 9e-23 79.8 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial carrier protein BTB PF00651.26 ESA20237.1 - 1.4e-14 54.0 0.0 2.4e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20237.1 - 3.2e-14 53.0 0.1 2.3e-13 50.3 0.0 2.2 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20237.1 - 2e-06 27.5 1.1 6.2e-05 22.7 0.1 2.6 1 1 1 2 2 2 2 BTB And C-terminal Kelch Cytotoxic PF09000.5 ESA20238.1 - 2.7e-19 68.9 0.0 3.6e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Cytotoxic p450 PF00067.17 ESA20240.1 - 5.8e-60 203.1 0.2 6.7e-60 202.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Herpes_UL92 PF03048.9 ESA20240.1 - 0.22 11.0 1.4 0.44 10.1 0.1 1.9 2 0 0 2 2 2 0 UL92 family zf-CCCH PF00642.19 ESA20242.1 - 0.00018 21.0 1.2 0.0003 20.3 0.8 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 ESA20242.1 - 0.67 10.0 3.6 1.6 8.8 2.5 1.6 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type ATG22 PF11700.3 ESA20243.1 - 0.0093 14.4 1.8 0.014 13.9 1.3 1.2 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Laminin_II PF06009.7 ESA20243.1 - 0.044 13.5 0.5 0.044 13.5 0.3 4.4 1 1 3 4 4 4 0 Laminin Domain II DUF2755 PF10954.3 ESA20243.1 - 0.093 12.4 1.7 0.45 10.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) TM_helix PF05552.7 ESA20243.1 - 2.4 7.8 7.1 0.2 11.3 1.2 2.0 2 0 0 2 2 2 0 Conserved TM helix Pkinase PF00069.20 ESA20244.1 - 2.8e-27 95.4 0.1 3e-27 95.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20244.1 - 2.6e-23 82.4 0.0 3.3e-23 82.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA20244.1 - 5.9e-05 22.5 0.0 7.5e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA20244.1 - 0.00066 19.4 0.1 0.00083 19.1 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20244.1 - 0.0048 15.9 0.1 0.006 15.6 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA20244.1 - 0.024 14.2 0.7 0.13 11.8 0.5 1.8 1 1 1 2 2 2 0 Choline/ethanolamine kinase WaaY PF06176.6 ESA20244.1 - 0.051 12.8 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA20244.1 - 0.083 11.8 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Kinase-like HSP70 PF00012.15 ESA20245.1 - 3.3e-187 623.1 5.1 3.7e-187 622.9 3.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA20245.1 - 6.5e-11 41.3 0.0 1.2e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA20245.1 - 0.051 12.6 1.3 0.076 12.0 0.1 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Cnd1_N PF12922.2 ESA20245.1 - 0.052 13.1 2.4 0.16 11.6 1.7 1.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Pkinase_Tyr PF07714.12 ESA20246.1 - 2.3e-48 164.5 0.0 2.8e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20246.1 - 2.5e-47 161.2 0.2 3.3e-47 160.8 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA20246.1 - 0.0019 17.3 0.0 0.003 16.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA20246.1 - 0.043 13.1 0.0 0.092 12.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ESA20246.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA20250.1 - 1.6e-30 106.0 0.0 1.8e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20250.1 - 9.2e-30 103.6 0.0 1.1e-29 103.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA20250.1 - 5.6e-05 22.9 0.0 9.6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA20250.1 - 7.8e-05 22.1 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA20250.1 - 0.0017 17.5 0.0 0.0026 16.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA20250.1 - 0.043 12.7 0.0 0.059 12.3 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 ESA20250.1 - 0.066 12.2 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2283 PF10049.4 ESA20251.1 - 7.1e-06 25.7 2.3 0.00026 20.7 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2283) OTU PF02338.14 ESA20253.1 - 1.4e-09 38.5 0.1 3.6e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease BTB PF00651.26 ESA20255.1 - 6.9e-22 77.5 1.0 1e-21 76.9 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA20255.1 - 3.4e-08 33.6 0.1 5.8e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA20255.1 - 0.00024 21.1 0.9 0.046 13.8 0.0 3.3 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain BTB PF00651.26 ESA20256.1 - 1.3e-21 76.6 2.3 1.2e-19 70.2 0.4 2.9 3 0 0 3 3 3 2 BTB/POZ domain SPRY PF00622.23 ESA20256.1 - 4.2e-08 33.3 0.2 7.3e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA20256.1 - 0.069 13.2 0.5 9.1 6.4 0.0 2.6 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain DUF4130 PF13566.1 ESA20256.1 - 0.09 12.3 0.0 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4130 BACK PF07707.10 ESA20256.1 - 1.3 8.9 5.5 2.1 8.1 0.4 3.4 3 1 1 4 4 4 0 BTB And C-terminal Kelch BTB PF00651.26 ESA20257.1 - 3.7e-21 75.1 0.1 8.5e-21 74.0 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.23 ESA20257.1 - 2.3e-09 37.4 0.3 4e-09 36.6 0.2 1.4 1 0 0 1 1 1 1 SPRY domain SPRY PF00622.23 ESA20258.1 - 9.3e-11 41.8 0.4 1.5e-10 41.2 0.3 1.2 1 0 0 1 1 1 1 SPRY domain Sec_GG PF07549.9 ESA20259.1 - 0.16 11.2 4.0 0.28 10.5 0.2 2.6 2 0 0 2 2 2 0 SecD/SecF GG Motif DUF2435 PF10363.4 ESA20262.1 - 0.0032 17.3 0.3 0.01 15.7 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2435) DDE_1 PF03184.14 ESA20263.1 - 3.8e-26 91.5 0.2 6.3e-26 90.8 0.2 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA20263.1 - 9.7e-11 41.3 0.1 1.9e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.8 ESA20263.1 - 7.9e-08 31.5 1.1 2.1e-07 30.2 0.8 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain CheR PF01739.13 ESA20263.1 - 0.069 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain AAA_18 PF13238.1 ESA20263.1 - 0.079 13.2 1.0 0.26 11.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain DDE_3 PF13358.1 ESA20263.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease Imm9 PF15561.1 ESA20265.1 - 0.011 15.3 0.0 1.2 8.7 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 9 DUF3635 PF12330.3 ESA20266.1 - 0.081 12.9 1.1 0.17 11.9 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3635) Melittin PF01372.12 ESA20268.1 - 0.49 9.7 2.8 0.95 8.8 0.0 2.7 3 0 0 3 3 3 0 Melittin F-box-like PF12937.2 ESA20269.1 - 0.0031 17.2 0.2 0.012 15.3 0.1 2.2 2 0 0 2 2 2 1 F-box-like bZIP_2 PF07716.10 ESA20270.1 - 1 9.2 10.0 3.5 7.5 0.8 2.8 3 0 0 3 3 3 0 Basic region leucine zipper FeoA PF04023.9 ESA20271.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 FeoA domain DUF2120 PF09893.4 ESA20272.1 - 0.015 15.2 0.8 0.018 15.0 0.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DUF2890 PF11081.3 ESA20272.1 - 0.36 10.8 3.6 0.41 10.6 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) DEAD PF00270.24 ESA20273.1 - 9.8e-44 148.8 0.0 1.7e-43 148.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA20273.1 - 1.6e-26 91.9 0.1 2.7e-25 88.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA20273.1 - 0.0054 16.5 0.0 0.023 14.5 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit 2OG-FeII_Oxy_4 PF13661.1 ESA20275.1 - 1.7e-05 24.3 0.1 4.7e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily ACBP PF00887.14 ESA20276.1 - 1.7e-23 82.0 1.0 1.9e-23 81.9 0.7 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein UvrB PF12344.3 ESA20276.1 - 0.013 14.9 0.1 0.02 14.3 0.1 1.3 1 0 0 1 1 1 0 Ultra-violet resistance protein B Amidinotransf PF02274.12 ESA20276.1 - 0.035 13.2 0.1 0.073 12.1 0.0 1.5 2 0 0 2 2 2 0 Amidinotransferase Pkinase_Tyr PF07714.12 ESA20277.1 - 3e-22 78.9 0.0 9.4e-15 54.3 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA20277.1 - 8.4e-19 67.7 4.0 6.6e-13 48.4 0.8 3.3 3 1 0 3 3 3 2 Protein kinase domain BCS1_N PF08740.6 ESA20277.1 - 0.00039 20.0 0.0 0.14 11.7 0.0 2.5 2 0 0 2 2 2 2 BCS1 N terminal Glyco_hydro_11 PF00457.12 ESA20277.1 - 0.014 14.7 1.4 1.6 8.0 0.0 2.8 2 2 0 2 2 2 0 Glycosyl hydrolases family 11 APG17 PF04108.7 ESA20278.1 - 8.8e-08 31.3 23.4 0.00041 19.2 7.4 3.5 2 1 1 3 3 3 2 Autophagy protein Apg17 Baculo_PEP_C PF04513.7 ESA20278.1 - 0.22 11.3 18.6 0.27 11.0 4.3 4.2 3 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.6 ESA20278.1 - 0.36 10.7 15.2 6.7 6.6 1.5 5.4 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.4 ESA20278.1 - 0.54 10.4 21.4 2.5 8.3 0.1 5.3 4 1 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WXG100 PF06013.7 ESA20278.1 - 2.4 8.2 7.0 0.6 10.1 0.1 3.6 4 0 0 4 4 4 0 Proteins of 100 residues with WXG Snapin_Pallidin PF14712.1 ESA20278.1 - 3.2 8.1 23.5 0.094 13.0 0.6 5.4 3 2 2 5 5 5 0 Snapin/Pallidin DUF4600 PF15372.1 ESA20278.1 - 6.5 6.9 13.6 0.19 11.9 2.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4600) LOH1CR12 PF10158.4 ESA20278.1 - 8.9 6.1 16.0 3.6 7.3 1.0 3.7 3 1 1 4 4 4 0 Tumour suppressor protein Calcipressin PF04847.7 ESA20279.1 - 3.3e-32 111.5 0.4 5.5e-32 110.8 0.3 1.3 1 1 0 1 1 1 1 Calcipressin RRM_5 PF13893.1 ESA20279.1 - 0.0089 15.8 0.1 0.018 14.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.12 ESA20282.1 - 3.5e-11 42.6 0.4 4.5e-05 22.6 0.0 4.2 3 1 1 4 4 4 3 Protein tyrosine kinase Pkinase PF00069.20 ESA20282.1 - 1.1e-09 37.8 10.2 0.00089 18.4 1.6 4.1 3 1 1 4 4 4 3 Protein kinase domain NOB1_Zn_bind PF08772.6 ESA20282.1 - 0.0065 16.2 18.6 0.74 9.6 0.1 4.9 5 0 0 5 5 5 2 Nin one binding (NOB1) Zn-ribbon like DUF4413 PF14372.1 ESA20282.1 - 0.38 10.7 14.8 3.9 7.5 0.3 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) T4SS PF07996.6 ESA20282.1 - 0.65 9.8 4.9 0.25 11.1 1.1 1.9 2 0 0 2 2 2 0 Type IV secretion system proteins DnaJ_CXXCXGXG PF00684.14 ESA20282.1 - 1.4 9.0 19.9 1.6 8.8 1.5 4.3 4 0 0 4 4 4 0 DnaJ central domain BCS1_N PF08740.6 ESA20283.1 - 5.3e-05 22.9 2.2 5.1 6.6 0.0 4.4 5 0 0 5 5 5 3 BCS1 N terminal DUF3299 PF11736.3 ESA20283.1 - 0.0033 17.3 0.0 8.6 6.2 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3299) NOB1_Zn_bind PF08772.6 ESA20283.1 - 0.0073 16.1 26.1 0.23 11.3 2.1 5.2 5 0 0 5 5 5 3 Nin one binding (NOB1) Zn-ribbon like VASP_tetra PF08776.6 ESA20283.1 - 0.3 10.4 0.1 0.3 10.4 0.0 3.8 4 0 0 4 4 4 0 VASP tetramerisation domain DUF4413 PF14372.1 ESA20283.1 - 1.5 8.8 14.9 8.1 6.4 0.1 5.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4413) Spt5-NGN PF03439.8 ESA20284.1 - 1.7e-06 27.6 1.4 1.2 8.8 0.0 4.6 4 0 0 4 4 4 3 Early transcription elongation factor of RNA pol II, NGN section DUF179 PF02622.10 ESA20284.1 - 0.015 14.9 6.7 1.1 8.8 0.1 3.9 4 0 0 4 4 4 0 Uncharacterized ACR, COG1678 Methyltransf_12 PF08242.7 ESA20284.1 - 0.085 13.3 0.1 23 5.5 0.0 3.9 3 0 0 3 3 3 0 Methyltransferase domain DUF4413 PF14372.1 ESA20284.1 - 3 7.8 18.8 7.6 6.5 0.2 5.9 5 1 0 5 5 5 0 Domain of unknown function (DUF4413) Spore_GerQ PF09671.5 ESA20285.1 - 0.064 12.9 0.2 0.58 9.8 0.0 2.1 2 0 0 2 2 2 0 Spore coat protein (Spore_GerQ) Alg6_Alg8 PF03155.10 ESA20286.1 - 1.7e-13 50.2 1.5 1.9e-13 50.0 1.0 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family BTD PF09270.5 ESA20288.1 - 3e-26 92.0 0.5 2.5e-23 82.5 0.3 2.6 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.6 ESA20288.1 - 6e-25 88.3 3.9 4.8e-23 82.1 2.7 2.8 1 1 0 1 1 1 1 LAG1, DNA binding MULE PF10551.4 ESA20290.1 - 1.4e-05 25.2 0.2 2.6e-05 24.2 0.0 1.5 2 0 0 2 2 2 1 MULE transposase domain Acyltransferase PF01553.16 ESA20291.1 - 6.9e-15 54.6 0.0 1.9e-14 53.2 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase Aa_trans PF01490.13 ESA20292.1 - 2.5e-62 210.7 27.2 3.4e-62 210.2 18.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TspO_MBR PF03073.10 ESA20292.1 - 0.13 11.7 8.2 0.018 14.5 2.2 2.2 2 0 0 2 2 2 0 TspO/MBR family DUF373 PF04123.8 ESA20292.1 - 4.4 6.2 9.3 1.4 7.9 4.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) UDPGT PF00201.13 ESA20293.1 - 7.1e-22 77.6 0.0 1.2e-21 76.9 0.0 1.5 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 ESA20293.1 - 6.7e-09 35.6 0.0 8.9e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 ESA20293.1 - 4.4e-06 26.1 0.0 8.6e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 1 BACK PF07707.10 ESA20294.1 - 1.4e-05 24.8 1.0 0.00023 20.9 0.3 2.5 1 1 1 2 2 2 2 BTB And C-terminal Kelch DUF1777 PF08648.7 ESA20295.1 - 0.025 14.3 7.2 0.026 14.2 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) PsbW PF07123.7 ESA20295.1 - 0.37 10.8 6.7 0.23 11.5 3.4 1.5 1 1 1 2 2 2 0 Photosystem II reaction centre W protein (PsbW) zf-rbx1 PF12678.2 ESA20299.1 - 0.038 14.1 0.1 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger DUF2063 PF09836.4 ESA20300.1 - 0.17 11.9 0.9 1.2 9.2 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2063) Rubella_Capsid PF05750.6 ESA20301.1 - 0.037 13.4 2.2 0.044 13.1 1.5 1.1 1 0 0 1 1 1 0 Rubella capsid protein MIF PF01187.13 ESA20302.1 - 2.8e-17 62.8 0.0 3.1e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Tautomerase PF01361.16 ESA20302.1 - 0.011 15.3 0.0 2 8.1 0.0 2.5 1 1 1 2 2 2 0 Tautomerase enzyme DEK_C PF08766.6 ESA20302.1 - 0.11 12.3 0.3 17 5.2 0.0 2.2 2 0 0 2 2 2 0 DEK C terminal domain DUF4413 PF14372.1 ESA20303.1 - 8.9e-08 32.0 0.4 1.1e-07 31.7 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Transposase_21 PF02992.9 ESA20304.1 - 0.0058 15.7 1.3 0.57 9.2 0.0 2.4 1 1 1 2 2 2 2 Transposase family tnp2 Pkinase_Tyr PF07714.12 ESA20307.1 - 1.5e-35 122.5 0.0 1.8e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20307.1 - 2.4e-33 115.3 0.0 3.4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA20307.1 - 0.0013 18.5 0.1 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20307.1 - 0.016 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4467 PF14729.1 ESA20308.1 - 0.14 12.5 1.2 0.16 12.3 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) DDE_1 PF03184.14 ESA20309.1 - 8.8e-20 70.7 0.5 1.1e-19 70.4 0.4 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA20309.1 - 0.053 13.2 0.1 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 DDE superfamily endonuclease Tetraspannin PF00335.15 ESA20309.1 - 0.079 12.2 0.5 0.09 12.0 0.4 1.3 1 0 0 1 1 1 0 Tetraspanin family WVELL PF14043.1 ESA20309.1 - 0.32 10.6 4.7 2.5 7.7 0.0 3.0 3 0 0 3 3 3 0 WVELL protein Pkinase_Tyr PF07714.12 ESA20310.1 - 2.8e-40 138.0 0.1 6.2e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20310.1 - 3.4e-34 118.1 1.4 9.1e-34 116.7 1.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA20310.1 - 1.4e-08 35.0 0.1 1.4e-08 35.0 0.1 3.6 3 1 0 3 3 3 1 Sel1 repeat End3 PF12761.2 ESA20310.1 - 0.084 12.5 7.2 0.026 14.1 2.7 1.9 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 SlyX PF04102.7 ESA20310.1 - 0.3 11.4 2.8 0.87 10.0 1.9 1.8 1 0 0 1 1 1 0 SlyX KxDL PF10241.4 ESA20310.1 - 9.5 6.1 9.8 0.79 9.6 2.2 2.6 4 0 0 4 4 4 0 Uncharacterized conserved protein DUF4261 PF14080.1 ESA20311.1 - 0.073 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) HMG_box PF00505.14 ESA20313.1 - 2.9e-15 56.2 0.0 3.4e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA20313.1 - 7.7e-06 26.1 0.0 1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain SRR PF07709.6 ESA20313.1 - 0.054 13.6 0.1 0.14 12.4 0.1 1.8 1 0 0 1 1 1 0 Seven Residue Repeat VitD-bind_III PF09164.5 ESA20313.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Myb_DNA-bind_4 PF13837.1 ESA20314.1 - 1.4e-10 41.1 3.7 1.4e-10 41.1 2.6 2.5 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA20314.1 - 0.0016 19.0 2.0 0.0016 19.0 1.4 3.0 2 1 2 4 4 4 1 Myb/SANT-like DNA-binding domain SOBP PF15279.1 ESA20314.1 - 0.15 12.4 5.8 0.18 12.1 4.1 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein PBP_sp32 PF07222.7 ESA20314.1 - 0.2 10.8 10.1 0.32 10.1 7.0 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 zf-RING_2 PF13639.1 ESA20318.1 - 6.1e-05 22.7 1.3 6.1e-05 22.7 0.9 1.8 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 ESA20318.1 - 9.3e-05 22.0 2.2 0.00021 20.9 1.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.2 ESA20318.1 - 0.0024 17.9 0.3 0.0047 17.0 0.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Nse PF11789.3 ESA20318.1 - 0.0084 15.6 3.4 0.019 14.4 2.4 1.7 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.1 ESA20318.1 - 0.012 15.6 3.2 0.059 13.4 2.3 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Myb_DNA-bind_3 PF12776.2 ESA20318.1 - 0.027 15.0 1.5 0.06 13.9 0.4 2.1 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain HALZ PF02183.13 ESA20318.1 - 0.1 12.3 3.8 0.22 11.2 2.6 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper GlutR_dimer PF00745.15 ESA20318.1 - 0.13 12.2 1.0 0.58 10.1 0.2 2.4 2 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Phage_Mu_F PF04233.9 ESA20319.1 - 0.091 13.2 3.0 0.15 12.6 0.7 2.2 2 1 0 2 2 2 0 Phage Mu protein F like protein TBCA PF02970.11 ESA20319.1 - 2.3 8.3 7.4 0.25 11.4 1.6 2.1 2 0 0 2 2 2 0 Tubulin binding cofactor A PIN_3 PF13470.1 ESA20320.1 - 0.13 12.9 0.1 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 PIN domain LRR_4 PF12799.2 ESA20322.1 - 0.0035 16.9 9.5 0.79 9.4 0.1 5.1 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA20322.1 - 0.042 13.6 10.5 2.3 8.0 0.7 4.5 3 2 1 4 4 4 0 Leucine rich repeat LRR_6 PF13516.1 ESA20322.1 - 0.73 10.0 11.4 23 5.4 0.1 5.7 4 1 1 5 5 5 0 Leucine Rich repeat LRR_7 PF13504.1 ESA20322.1 - 2.6 8.6 5.1 78 4.1 0.1 4.8 4 1 0 4 4 4 0 Leucine rich repeat DUF4379 PF14311.1 ESA20326.1 - 0.00051 19.8 3.9 0.00074 19.2 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) Herpes_UL73 PF03554.8 ESA20327.1 - 0.32 10.8 1.7 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein zf-UDP PF14569.1 ESA20327.1 - 9.6 6.0 8.5 1.8 8.3 0.1 2.9 3 0 0 3 3 3 0 Zinc-binding RING-finger ENT PF03735.9 ESA20328.1 - 0.029 14.0 0.6 0.085 12.5 0.5 1.7 2 0 0 2 2 2 0 ENT domain DUF972 PF06156.8 ESA20328.1 - 0.053 13.8 1.8 0.099 12.9 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Herpes_UL6 PF01763.11 ESA20328.1 - 0.076 11.1 2.8 0.1 10.7 2.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like HemX PF04375.9 ESA20328.1 - 0.16 10.5 6.1 0.24 9.9 4.2 1.3 1 0 0 1 1 1 0 HemX DUF2956 PF11169.3 ESA20328.1 - 0.54 10.2 5.1 0.89 9.5 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) IncA PF04156.9 ESA20328.1 - 1.7 8.1 11.3 3.4 7.2 7.8 1.7 1 1 0 1 1 1 0 IncA protein Jnk-SapK_ap_N PF09744.4 ESA20328.1 - 2.7 7.9 7.4 0.65 9.9 2.9 1.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Calici_PP_N PF08405.6 ESA20330.1 - 0.061 12.1 0.1 2.6 6.8 0.0 2.0 2 0 0 2 2 2 0 Viral polyprotein N-terminal Cas_TM1802 PF09484.5 ESA20330.1 - 0.069 11.6 0.5 0.077 11.4 0.4 1.1 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) Pkinase PF00069.20 ESA20331.1 - 6.5e-22 77.9 0.4 1.8e-15 56.8 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20331.1 - 2.7e-19 69.2 0.0 9.4e-09 34.7 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Foie-gras_1 PF11817.3 ESA20333.1 - 1.6e-41 142.3 0.1 1.1e-39 136.4 0.0 2.3 2 0 0 2 2 2 1 Foie gras liver health family 1 TPR_12 PF13424.1 ESA20333.1 - 0.00025 20.9 3.4 0.074 12.9 0.4 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA20333.1 - 0.018 14.7 1.2 3.4 7.6 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA20333.1 - 0.025 14.1 1.4 3.5 7.3 0.1 2.6 2 0 0 2 2 2 0 TPR repeat TPR_1 PF00515.23 ESA20333.1 - 0.079 12.6 2.7 0.61 9.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA20333.1 - 0.29 11.8 1.4 3.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA20334.1 - 6.9e-06 25.4 0.2 0.00029 20.0 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain DUF4423 PF14394.1 ESA20334.1 - 0.0062 16.0 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) APH PF01636.18 ESA20334.1 - 0.017 14.8 0.5 0.028 14.1 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Imm22 PF15592.1 ESA20336.1 - 0.0026 18.0 0.1 0.0026 18.0 0.1 2.0 1 1 0 2 2 2 1 Immunity protein 22 tRNA-synt_His PF13393.1 ESA20336.1 - 0.15 11.0 2.4 0.16 11.0 1.7 1.2 1 0 0 1 1 1 0 Histidyl-tRNA synthetase AAA_23 PF13476.1 ESA20336.1 - 0.19 12.0 17.9 0.21 11.8 12.4 1.1 1 0 0 1 1 1 0 AAA domain SidE PF12252.3 ESA20336.1 - 0.22 8.8 8.4 0.23 8.7 5.8 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein NPV_P10 PF05531.7 ESA20336.1 - 0.83 9.9 7.1 0.31 11.3 1.7 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein CDC37_N PF03234.9 ESA20336.1 - 1.9 8.8 15.5 38 4.5 10.7 2.3 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding Fib_alpha PF08702.5 ESA20336.1 - 2.5 8.2 9.3 4 7.5 6.4 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family MerR-DNA-bind PF09278.6 ESA20336.1 - 6.3 7.2 9.1 5.1 7.5 0.6 2.7 2 1 1 3 3 3 0 MerR, DNA binding DUF4387 PF14330.1 ESA20337.1 - 0.04 14.2 0.6 0.13 12.6 0.1 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4387) GPAT_N PF14829.1 ESA20337.1 - 0.051 13.2 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal SAP30_Sin3_bdg PF13867.1 ESA20337.1 - 0.18 11.7 1.2 0.58 10.0 0.1 2.4 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Myb_DNA-bind_4 PF13837.1 ESA20338.1 - 1.3e-09 38.0 0.9 1.8e-09 37.5 0.2 1.5 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain PriCT_2 PF08707.6 ESA20338.1 - 0.0065 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Primase C terminal 2 (PriCT-2) Myb_DNA-bind_6 PF13921.1 ESA20338.1 - 0.012 15.7 0.2 0.053 13.6 0.1 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain Collagen_bind PF05737.7 ESA20338.1 - 0.013 15.6 0.1 5.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Collagen binding domain MADF_DNA_bdg PF10545.4 ESA20338.1 - 0.023 14.8 0.9 0.053 13.7 0.2 1.8 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Ribosomal_60s PF00428.14 ESA20340.1 - 0.00057 20.2 6.6 0.00066 20.0 4.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Calici_coat PF00915.15 ESA20340.1 - 0.18 10.6 0.3 0.19 10.6 0.2 1.0 1 0 0 1 1 1 0 Calicivirus coat protein Sel1 PF08238.7 ESA20341.1 - 3.3e-50 167.4 9.1 5.4e-12 45.9 0.2 6.5 6 0 0 6 6 6 5 Sel1 repeat Pkinase PF00069.20 ESA20341.1 - 5e-27 94.6 0.0 1.1e-26 93.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20341.1 - 5.4e-27 94.4 0.0 7.9e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20341.1 - 0.0011 18.0 0.0 0.0018 17.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA20341.1 - 0.017 14.1 0.1 0.04 12.9 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA20341.1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_17 PF13431.1 ESA20341.1 - 2.5 8.5 5.6 7 7.1 0.2 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat 7tm_1 PF00001.16 ESA20343.1 - 8.9e-09 34.8 5.1 2.2e-08 33.5 0.3 2.3 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) SNARE_assoc PF09335.6 ESA20343.1 - 0.12 12.5 1.8 3.1 8.0 0.2 2.4 2 0 0 2 2 2 0 SNARE associated Golgi protein DASH_Dad4 PF08650.5 ESA20345.1 - 0.26 11.1 2.7 0.46 10.4 1.9 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad4 JmjC PF02373.17 ESA20346.1 - 7.3e-39 132.5 0.5 1.8e-38 131.2 0.4 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 ESA20346.1 - 3.2e-14 52.1 1.8 6.6e-14 51.1 1.2 1.6 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.1 ESA20346.1 - 8.3e-13 48.2 2.1 8.3e-13 48.2 1.5 2.1 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESA20346.1 - 4.5e-09 36.2 4.4 6.6e-09 35.7 2.4 1.8 1 1 0 1 1 1 1 PHD-zinc-finger like domain DUF1777 PF08648.7 ESA20347.1 - 0.0061 16.3 15.3 0.0068 16.1 10.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) BEN PF10523.4 ESA20347.1 - 0.012 15.6 0.6 3.2 7.8 0.2 2.6 2 1 0 2 2 2 0 BEN domain DUF605 PF04652.11 ESA20347.1 - 0.053 12.9 17.1 0.06 12.7 11.8 1.0 1 0 0 1 1 1 0 Vta1 like DNA_pol_viral_N PF00242.12 ESA20347.1 - 0.28 10.1 18.4 0.36 9.8 12.8 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Macoilin PF09726.4 ESA20347.1 - 0.57 8.4 16.5 0.61 8.2 11.4 1.0 1 0 0 1 1 1 0 Transmembrane protein Exonuc_VII_L PF02601.10 ESA20347.1 - 0.92 8.6 8.5 1.2 8.2 5.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit KIAA1328 PF15369.1 ESA20347.1 - 1.5 8.5 10.4 1.7 8.4 7.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Peptidase_S64 PF08192.6 ESA20347.1 - 1.6 6.9 12.7 1.7 6.8 8.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Sec10 PF07393.6 ESA20347.1 - 1.6 6.7 8.3 1.8 6.6 5.8 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 DUF2217 PF10265.4 ESA20347.1 - 2.8 6.5 11.6 3.2 6.3 8.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Hid1 PF12722.2 ESA20347.1 - 4.4 4.8 18.2 4.9 4.7 12.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4551 PF15087.1 ESA20347.1 - 5.6 5.2 13.9 6.1 5.0 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Gag_spuma PF03276.9 ESA20347.1 - 6.4 4.9 17.1 7.1 4.8 11.8 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Pol_alpha_B_N PF08418.5 ESA20347.1 - 6.4 6.2 18.2 8 5.9 12.6 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Neur_chan_memb PF02932.11 ESA20347.1 - 8.6 6.1 7.7 10 5.9 5.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Menin PF05053.8 ESA20347.1 - 9.6 4.2 12.7 12 3.9 8.8 1.2 1 0 0 1 1 1 0 Menin BTB PF00651.26 ESA20348.1 - 7.8e-08 32.2 0.0 8.8e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain Dimer_Tnp_hAT PF05699.9 ESA20351.1 - 8.6e-09 34.9 0.0 1.9e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA20351.1 - 0.00076 19.4 0.2 0.0017 18.3 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) Ribosomal_S7e PF01251.13 ESA20351.1 - 0.003 17.0 0.3 0.0039 16.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S7e PBP1_TM PF14812.1 ESA20351.1 - 4.6 7.6 6.6 8.1 6.8 0.7 2.4 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tropomyosin_1 PF12718.2 ESA20352.1 - 0.0011 18.7 17.3 0.006 16.4 3.5 3.9 3 1 1 4 4 4 2 Tropomyosin like DUF3166 PF11365.3 ESA20352.1 - 0.011 16.1 6.0 0.39 11.1 0.6 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) bZIP_1 PF00170.16 ESA20352.1 - 0.016 15.1 30.7 0.036 14.0 2.7 5.3 5 1 0 5 5 4 0 bZIP transcription factor TFR_dimer PF04253.10 ESA20352.1 - 0.065 12.8 1.7 0.14 11.7 0.2 2.3 2 0 0 2 2 2 0 Transferrin receptor-like dimerisation domain Cep57_CLD_2 PF14197.1 ESA20352.1 - 0.085 12.8 0.5 0.085 12.8 0.3 3.5 4 0 0 4 4 3 0 Centrosome localisation domain of PPC89 DUF4241 PF14025.1 ESA20352.1 - 0.34 10.6 2.4 0.27 10.9 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) Pedibin PF08182.6 ESA20352.1 - 0.75 9.3 22.7 0.13 11.7 0.8 4.4 4 1 1 5 5 5 0 Pedibin/Hym-346 family TSC22 PF01166.13 ESA20352.1 - 0.82 9.6 19.0 2.9 7.9 0.7 4.5 3 1 1 4 4 4 0 TSC-22/dip/bun family TMF_TATA_bd PF12325.3 ESA20352.1 - 1.7 8.4 21.6 0.15 11.7 1.2 4.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding PP_kinase_N PF13089.1 ESA20352.1 - 2 8.5 7.4 23 5.1 0.0 4.1 3 1 0 3 3 3 0 Polyphosphate kinase N-terminal domain Tropomyosin PF00261.15 ESA20352.1 - 2.7 7.0 24.8 0.02 13.9 1.0 3.8 4 0 0 4 4 4 0 Tropomyosin ADIP PF11559.3 ESA20352.1 - 3.1 7.6 30.7 0.024 14.5 2.5 4.0 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding DUF4140 PF13600.1 ESA20352.1 - 7 7.1 11.6 8 6.9 0.2 3.8 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) Adeno_100 PF02438.11 ESA20354.1 - 0.00022 19.6 0.0 0.00022 19.6 0.0 1.1 1 0 0 1 1 1 1 Late 100kD protein DUF2661 PF10860.3 ESA20354.1 - 0.04 14.1 0.8 0.069 13.3 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2661) MS_channel PF00924.13 ESA20354.1 - 0.04 13.2 1.0 0.058 12.7 0.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel CotH PF08757.6 ESA20354.1 - 4.7 6.3 9.4 0.31 10.2 2.2 1.9 1 1 0 2 2 2 0 CotH protein HMG_box PF00505.14 ESA20356.1 - 6e-05 23.2 0.2 0.00012 22.2 0.1 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA20356.1 - 0.0016 18.7 0.1 0.0025 18.1 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain Ras PF00071.17 ESA20360.1 - 1.1e-54 184.2 0.0 1.3e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA20360.1 - 1.1e-15 58.1 0.0 1.6e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA20360.1 - 2.4e-07 30.1 0.0 3.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 ESA20360.1 - 0.0013 17.9 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESA20360.1 - 0.057 12.5 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Thioredoxin PF00085.15 ESA20361.1 - 1.2e-27 95.6 0.1 1.3e-27 95.5 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESA20361.1 - 5.3e-09 36.0 0.2 1.8e-08 34.3 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 ESA20361.1 - 5.9e-09 35.6 0.1 1.1e-08 34.7 0.0 1.4 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.1 ESA20361.1 - 2.3e-07 30.9 0.0 1.6e-06 28.2 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 ESA20361.1 - 8.4e-05 22.1 0.1 0.00019 21.0 0.1 1.5 1 1 1 2 2 2 1 Redoxin DIM1 PF02966.11 ESA20361.1 - 0.00024 20.6 0.0 0.00028 20.4 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_7 PF13899.1 ESA20361.1 - 0.00025 21.0 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 ESA20361.1 - 0.00027 20.5 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.6 ESA20361.1 - 0.0029 17.4 0.0 0.0041 16.9 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.1 ESA20361.1 - 0.005 16.6 0.0 0.0077 16.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain DUF713 PF05218.9 ESA20361.1 - 0.02 14.5 0.2 0.03 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Phosducin PF02114.11 ESA20361.1 - 0.027 13.1 0.0 0.029 13.0 0.0 1.1 1 0 0 1 1 1 0 Phosducin LRR_4 PF12799.2 ESA20363.1 - 8.2 6.1 27.5 0.46 10.1 0.7 6.1 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) ANTH PF07651.11 ESA20365.1 - 2.8e-69 232.9 0.0 2.8e-69 232.9 0.0 3.9 4 1 1 5 5 5 1 ANTH domain I_LWEQ PF01608.12 ESA20365.1 - 1e-63 213.8 12.9 1e-63 213.8 9.0 6.3 4 3 3 7 7 7 1 I/LWEQ domain Adeno_E3B PF03376.9 ESA20365.1 - 0.24 11.3 0.1 0.55 10.1 0.1 1.6 1 0 0 1 1 1 0 Adenovirus E3B protein RRM_6 PF14259.1 ESA20366.1 - 2.3e-13 49.9 0.0 1.8e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA20366.1 - 1.1e-12 47.3 0.0 9.1e-08 31.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA20366.1 - 6.8e-07 29.0 0.0 0.0065 16.2 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_4 PF12799.2 ESA20367.1 - 2.2e-05 23.9 11.5 0.031 13.8 1.1 3.6 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA20367.1 - 0.0037 16.9 8.3 0.13 12.0 4.8 3.3 2 1 1 3 3 3 2 Leucine rich repeat Endonuc-BglII PF09195.6 ESA20367.1 - 0.031 13.7 2.9 0.21 11.0 0.0 2.3 2 1 0 2 2 2 0 Restriction endonuclease BglII Rho_Binding PF08912.6 ESA20367.1 - 0.047 13.9 1.8 0.047 13.9 1.2 3.4 2 1 0 3 3 3 0 Rho Binding DUF743 PF05332.6 ESA20367.1 - 0.71 9.8 3.5 0.19 11.6 0.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF743) AIG1 PF04548.11 ESA20368.1 - 9.5e-06 24.8 4.6 0.0013 17.9 3.2 2.0 1 1 0 1 1 1 1 AIG1 family AAA_18 PF13238.1 ESA20368.1 - 0.00019 21.7 0.0 0.00022 21.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA20368.1 - 0.00062 20.5 0.0 0.00071 20.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESA20368.1 - 0.0017 18.6 0.0 0.0017 18.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.11 ESA20368.1 - 0.0022 17.1 0.7 0.0036 16.5 0.3 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 ESA20368.1 - 0.0023 17.8 1.3 0.0046 16.9 0.9 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arch_ATPase PF01637.13 ESA20368.1 - 0.0092 15.7 0.7 0.011 15.4 0.5 1.2 1 0 0 1 1 1 1 Archaeal ATPase Septin PF00735.13 ESA20368.1 - 0.015 14.3 0.1 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_16 PF13191.1 ESA20368.1 - 0.024 14.6 0.1 0.029 14.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.1 ESA20368.1 - 0.047 13.2 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.4 ESA20368.1 - 0.062 12.7 0.1 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TINF2_N PF14973.1 ESA20368.1 - 0.064 13.3 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus GTP_EFTU PF00009.22 ESA20368.1 - 0.13 11.6 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MNE1 PF13762.1 ESA20369.1 - 0.048 13.7 0.9 0.42 10.6 0.6 2.0 1 1 0 1 1 1 0 Mitochondrial splicing apparatus component DUF1722 PF08349.6 ESA20369.1 - 0.11 12.3 1.2 1.2 8.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1722) DUF3298 PF11738.3 ESA20370.1 - 0.27 11.7 1.3 1.4 9.4 0.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3298) bZIP_2 PF07716.10 ESA20373.1 - 1.9e-07 30.7 5.7 3e-07 30.1 3.9 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 ESA20373.1 - 6.1e-06 26.1 6.6 8.9e-06 25.5 4.5 1.2 1 0 0 1 1 1 1 bZIP transcription factor HALZ PF02183.13 ESA20373.1 - 0.014 15.1 1.0 0.029 14.0 0.7 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper BLOC1_2 PF10046.4 ESA20373.1 - 0.014 15.5 2.3 0.021 14.9 1.6 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Surfac_D-trimer PF09006.6 ESA20373.1 - 0.027 14.2 0.1 0.081 12.6 0.0 1.8 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation bZIP_Maf PF03131.12 ESA20373.1 - 0.068 13.4 3.1 0.098 12.9 2.1 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF2400 PF09674.5 ESA20373.1 - 0.46 10.1 3.6 0.28 10.8 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) Rdx PF10262.4 ESA20378.1 - 5e-30 103.3 0.0 6.6e-30 102.9 0.0 1.2 1 0 0 1 1 1 1 Rdx family Peptidase_C2 PF00648.16 ESA20379.1 - 5.7e-89 298.0 0.1 2.6e-87 292.6 0.1 2.2 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 ESA20379.1 - 1.1e-33 115.9 0.6 3.2e-33 114.4 0.1 2.0 2 0 0 2 2 2 1 Calpain large subunit, domain III Cyclin_N PF00134.18 ESA20380.1 - 1.3e-12 47.4 0.1 1.5e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain GAGA_bind PF06217.7 ESA20382.1 - 0.24 11.3 7.6 0.097 12.6 3.3 1.7 1 1 1 2 2 2 0 GAGA binding protein-like family DUF3552 PF12072.3 ESA20382.1 - 5.9 6.0 14.0 8.3 5.5 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Pkinase_Tyr PF07714.12 ESA20384.1 - 2.1e-49 167.9 0.0 3.4e-49 167.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20384.1 - 2.5e-47 161.2 0.0 7.6e-47 159.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA20384.1 - 0.0053 16.5 0.1 0.019 14.6 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA20384.1 - 0.051 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.20 ESA20385.1 - 1.5e-06 27.5 0.2 0.00014 21.1 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20385.1 - 0.00038 19.6 0.0 0.0085 15.1 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase PsbU PF06514.6 ESA20385.1 - 0.098 12.5 1.3 0.14 12.0 0.1 1.9 1 1 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) DUF4433 PF14487.1 ESA20387.1 - 0.018 14.8 0.1 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4433) Globin PF00042.17 ESA20388.1 - 0.038 14.3 9.2 0.23 11.7 0.1 4.0 2 1 2 4 4 4 0 Globin HEPN PF05168.9 ESA20389.1 - 0.0052 16.6 0.5 0.0065 16.3 0.3 1.3 1 0 0 1 1 1 1 HEPN domain PBP1_TM PF14812.1 ESA20389.1 - 0.032 14.5 1.5 0.047 14.0 1.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ANTH PF07651.11 ESA20389.1 - 0.047 12.4 0.7 0.049 12.3 0.5 1.1 1 0 0 1 1 1 0 ANTH domain FAM178 PF14816.1 ESA20389.1 - 0.1 11.2 1.1 0.12 11.0 0.8 1.0 1 0 0 1 1 1 0 Family of unknown function, FAM178 RNA_pol_Rpb5_C PF01191.14 ESA20390.1 - 1.1e-13 50.5 0.2 2.5e-13 49.4 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain DUF3650 PF12368.3 ESA20390.1 - 0.084 12.3 0.2 0.19 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3650) Dimer_Tnp_hAT PF05699.9 ESA20392.1 - 1.1e-19 69.8 0.8 1.3e-19 69.5 0.1 1.4 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region DUF1571 PF07608.6 ESA20393.1 - 0.021 13.9 0.8 0.027 13.5 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1571) Tnp_P_element_C PF12596.3 ESA20393.1 - 1.9 8.8 8.0 2.5 8.4 5.6 1.2 1 0 0 1 1 1 0 87kDa Transposase COX5B PF01215.14 ESA20394.1 - 2.1e-37 127.8 0.0 2.7e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-C4_Topoisom PF01396.14 ESA20394.1 - 0.027 13.9 0.6 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger CTNNB1_binding PF08347.6 ESA20394.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 1 1 2 2 2 0 N-terminal CTNNB1 binding Tom37 PF10568.4 ESA20395.1 - 3.9e-17 62.2 0.0 1e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Tom37_C PF11801.3 ESA20395.1 - 1.3e-12 47.9 10.4 1.2e-08 35.0 0.2 3.1 2 1 1 3 3 3 2 Tom37 C-terminal domain GST_C_3 PF14497.1 ESA20395.1 - 3.2e-07 30.7 0.1 2.8e-06 27.7 0.0 2.3 3 0 0 3 3 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 ESA20395.1 - 8.7e-06 25.6 0.0 1.8e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PEN-2 PF10251.4 ESA20395.1 - 0.0024 18.0 0.0 0.006 16.7 0.0 1.6 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase GST_C_2 PF13410.1 ESA20395.1 - 0.0034 17.2 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Cwf_Cwc_15 PF04889.7 ESA20395.1 - 0.029 14.0 8.5 0.038 13.6 5.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.4 ESA20395.1 - 0.049 12.3 19.0 0.062 12.0 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.6 ESA20395.1 - 0.22 11.3 8.0 0.38 10.5 5.6 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2076 PF09849.4 ESA20395.1 - 2.6 8.0 10.3 3.4 7.6 7.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Nop14 PF04147.7 ESA20395.1 - 4.4 5.1 12.1 5.4 4.7 8.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.9 ESA20395.1 - 5.7 4.8 8.7 7.1 4.5 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Dus PF01207.12 ESA20396.1 - 2.2e-76 256.6 0.0 2.6e-76 256.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SOR_SNZ PF01680.12 ESA20396.1 - 0.00032 20.3 0.1 0.01 15.4 0.0 2.1 1 1 1 2 2 2 1 SOR/SNZ family His_biosynth PF00977.16 ESA20396.1 - 0.00096 18.4 0.0 0.0026 17.0 0.0 1.7 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.9 ESA20396.1 - 0.068 12.2 0.0 0.098 11.7 0.0 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG NMO PF03060.10 ESA20396.1 - 0.15 11.2 0.0 0.39 9.8 0.0 1.6 1 1 1 2 2 2 0 Nitronate monooxygenase Endonuclease_5 PF04493.9 ESA20397.1 - 2.9e-61 206.4 0.0 3.7e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V F-box-like PF12937.2 ESA20399.1 - 0.04 13.6 0.6 0.089 12.5 0.4 1.6 1 0 0 1 1 1 0 F-box-like Pkinase PF00069.20 ESA20400.1 - 3.4e-26 91.9 0.0 4.9e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20400.1 - 8.3e-25 87.3 0.0 1.1e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20400.1 - 0.032 13.9 0.1 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PsbU PF06514.6 ESA20400.1 - 0.1 12.4 0.3 0.36 10.7 0.1 1.9 2 0 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) F-box-like PF12937.2 ESA20401.1 - 0.00042 19.9 0.2 0.00066 19.3 0.1 1.3 1 0 0 1 1 1 1 F-box-like DUF1374 PF07118.6 ESA20402.1 - 0.064 13.3 1.2 0.12 12.4 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) Mating_N PF12731.2 ESA20402.1 - 0.065 13.1 0.3 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 LRR_6 PF13516.1 ESA20402.1 - 0.45 10.7 1.9 2 8.7 0.1 3.0 3 0 0 3 3 3 0 Leucine Rich repeat F-box-like PF12937.2 ESA20403.1 - 0.0013 18.4 0.3 0.0042 16.7 0.2 1.9 1 0 0 1 1 1 1 F-box-like ubiquitin PF00240.18 ESA20404.1 - 5.9e-12 44.8 0.0 1.1e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 ESA20404.1 - 1.1e-08 34.6 0.8 3.2e-08 33.1 0.5 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 ESA20404.1 - 1.9e-06 27.4 0.0 4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA20404.1 - 3.5e-06 27.1 0.1 1.1e-05 25.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA20404.1 - 7.8e-05 22.5 0.0 0.00068 19.5 0.0 2.5 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Nop14 PF04147.7 ESA20405.1 - 0.005 14.8 7.1 0.0056 14.6 4.9 1.0 1 0 0 1 1 1 1 Nop14-like family V-SNARE PF05008.10 ESA20405.1 - 0.0064 16.6 3.6 0.011 15.8 2.5 1.4 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus Atg14 PF10186.4 ESA20405.1 - 0.0066 15.4 1.1 0.0072 15.3 0.8 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Microtub_assoc PF07989.6 ESA20405.1 - 0.009 15.8 6.5 0.018 14.8 4.5 1.5 1 0 0 1 1 1 1 Microtubule associated ATG16 PF08614.6 ESA20405.1 - 0.013 15.3 4.6 0.016 15.0 3.2 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GLE1 PF07817.8 ESA20405.1 - 0.014 14.3 0.1 0.018 13.9 0.1 1.2 1 0 0 1 1 1 0 GLE1-like protein Med9 PF07544.8 ESA20405.1 - 0.017 14.8 3.6 0.033 13.9 2.5 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4515 PF14988.1 ESA20405.1 - 0.02 14.5 9.6 0.027 14.1 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) McrBC PF10117.4 ESA20405.1 - 0.028 13.3 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component Spc7 PF08317.6 ESA20405.1 - 0.028 13.0 4.6 0.031 12.9 3.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Sec8_exocyst PF04048.9 ESA20405.1 - 0.029 13.9 2.1 0.052 13.1 1.4 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF342 PF03961.8 ESA20405.1 - 0.032 12.6 2.4 0.033 12.6 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CDC37_N PF03234.9 ESA20405.1 - 0.085 13.1 4.1 0.11 12.8 2.8 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF812 PF05667.6 ESA20405.1 - 0.088 11.3 5.3 0.095 11.2 3.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FUSC-like PF12805.2 ESA20405.1 - 0.12 11.2 0.4 0.15 10.9 0.3 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DASH_Duo1 PF08651.5 ESA20405.1 - 0.14 11.7 4.0 4.7 6.8 0.7 2.4 1 1 1 2 2 2 0 DASH complex subunit Duo1 DUF4618 PF15397.1 ESA20405.1 - 0.16 11.2 6.7 0.22 10.8 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Mod_r PF07200.8 ESA20405.1 - 0.16 11.8 9.8 0.12 12.3 5.5 1.6 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein V_ATPase_I PF01496.14 ESA20405.1 - 0.22 9.3 6.0 0.24 9.2 4.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DMPK_coil PF08826.5 ESA20405.1 - 0.23 11.3 9.9 0.53 10.2 6.9 1.5 1 0 0 1 1 1 0 DMPK coiled coil domain like Lge1 PF11488.3 ESA20405.1 - 0.26 11.4 3.1 0.43 10.7 2.1 1.3 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 AATF-Che1 PF13339.1 ESA20405.1 - 0.37 10.9 5.2 0.3 11.2 2.1 1.8 1 1 1 2 2 1 0 Apoptosis antagonizing transcription factor TMF_DNA_bd PF12329.3 ESA20405.1 - 0.38 10.5 12.6 0.74 9.6 8.7 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Prefoldin PF02996.12 ESA20405.1 - 0.68 9.5 9.8 0.38 10.4 5.3 1.7 2 0 0 2 2 2 0 Prefoldin subunit DUF2458 PF10454.4 ESA20405.1 - 0.82 9.5 10.5 1.9 8.3 3.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2458) Fzo_mitofusin PF04799.8 ESA20405.1 - 1 8.7 4.0 1.4 8.2 2.8 1.3 1 0 0 1 1 1 0 fzo-like conserved region AAA_23 PF13476.1 ESA20405.1 - 1.5 9.0 13.6 2.1 8.6 9.4 1.1 1 0 0 1 1 1 0 AAA domain NifW PF03206.9 ESA20405.1 - 2.6 8.2 6.2 7.3 6.7 0.2 2.3 1 1 0 2 2 2 0 Nitrogen fixation protein NifW bZIP_1 PF00170.16 ESA20405.1 - 2.9 7.8 10.6 1.1 9.2 1.6 2.4 1 1 1 2 2 2 0 bZIP transcription factor CENP-Q PF13094.1 ESA20405.1 - 5.1 7.0 13.6 2.1 8.3 7.4 1.7 1 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF241 PF03087.9 ESA20405.1 - 6.3 6.2 9.2 9.1 5.6 6.4 1.4 1 1 0 1 1 1 0 Arabidopsis protein of unknown function TLD PF07534.11 ESA20406.1 - 4.8e-11 42.8 0.2 1.1e-10 41.6 0.1 1.6 2 0 0 2 2 2 1 TLD DUF2414 PF10309.4 ESA20408.1 - 0.0084 15.7 0.2 0.21 11.3 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF2414) BTB PF00651.26 ESA20409.1 - 3.1e-09 36.7 0.0 6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20409.1 - 1.4e-07 31.2 3.4 4.2e-06 26.5 0.2 3.6 2 1 2 4 4 4 1 BTB And C-terminal Kelch DUF4576 PF15144.1 ESA20409.1 - 0.12 12.0 0.6 0.75 9.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) ABC_tran PF00005.22 ESA20410.1 - 2.3e-11 44.1 0.1 2.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 ESA20410.1 - 0.0021 17.5 0.0 0.0042 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 ESA20410.1 - 0.0021 17.4 0.0 0.0035 16.7 0.0 1.4 1 1 1 2 2 2 1 AAA domain DUF258 PF03193.11 ESA20410.1 - 0.0026 16.9 0.0 0.0029 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 ESA20410.1 - 0.0027 17.7 0.3 0.0035 17.3 0.2 1.2 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 ESA20410.1 - 0.0052 15.5 0.0 0.0052 15.5 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 ESA20410.1 - 0.0058 17.4 0.0 0.0079 17.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA20410.1 - 0.0099 16.0 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA20410.1 - 0.017 15.1 0.0 0.017 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.9 ESA20410.1 - 0.017 14.8 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 ESA20410.1 - 0.028 14.7 0.0 0.039 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESA20410.1 - 0.081 12.5 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA20410.1 - 0.096 12.5 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESA20410.1 - 0.13 11.3 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 ESA20410.1 - 0.13 12.1 0.3 0.65 9.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain Pkinase_Tyr PF07714.12 ESA20411.1 - 6.9e-31 107.2 0.0 1.6e-30 106.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20411.1 - 7.9e-31 107.1 1.5 2.2e-30 105.6 1.1 1.7 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA20411.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 BCS1 N terminal VIT PF08487.5 ESA20412.1 - 1.1e-21 76.6 0.5 2.3e-21 75.6 0.3 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.1 ESA20412.1 - 1.7e-10 40.1 0.0 2.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF3438 PF11920.3 ESA20412.1 - 0.081 11.7 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) BTB PF00651.26 ESA20413.1 - 1.1e-18 67.2 0.1 2.2e-18 66.2 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20413.1 - 3.4e-12 46.5 1.0 3.4e-12 46.5 0.7 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20413.1 - 1.7e-05 24.6 5.0 3.7e-05 23.4 0.3 3.8 3 1 1 4 4 4 1 BTB And C-terminal Kelch BTB PF00651.26 ESA20414.1 - 2.8e-10 40.1 1.0 2.8e-10 40.1 0.7 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA20414.1 - 0.0002 21.1 5.7 0.00027 20.7 2.1 2.4 1 1 1 2 2 2 1 BTB And C-terminal Kelch T4_Gp59_N PF08993.5 ESA20414.1 - 0.015 15.2 0.1 0.015 15.2 0.1 2.3 2 1 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase Myosin_tail_1 PF01576.14 ESA20415.1 - 0.0055 14.4 11.1 0.0063 14.3 7.7 1.0 1 0 0 1 1 1 1 Myosin tail RP-C_C PF11800.3 ESA20415.1 - 0.013 15.2 4.9 0.016 14.9 3.4 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF2621 PF11084.3 ESA20415.1 - 0.034 13.8 0.3 0.045 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) Cbl_N PF02262.11 ESA20415.1 - 0.071 12.8 1.4 0.11 12.2 0.4 1.6 1 1 1 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DUF4509 PF14970.1 ESA20415.1 - 0.071 12.7 4.0 0.066 12.8 2.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4509) HALZ PF02183.13 ESA20415.1 - 0.073 12.8 4.5 1.7 8.4 0.8 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF904 PF06005.7 ESA20415.1 - 0.088 13.1 11.2 1 9.6 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Mto2_bdg PF12808.2 ESA20415.1 - 0.089 12.9 4.8 3.8 7.6 0.7 2.6 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Speriolin_N PF15058.1 ESA20415.1 - 0.096 12.5 2.2 0.54 10.1 0.5 2.1 1 1 1 2 2 2 0 Speriolin N terminus Microtub_assoc PF07989.6 ESA20415.1 - 0.27 11.0 5.2 2.4 8.0 1.6 2.4 2 0 0 2 2 2 0 Microtubule associated Spore_III_AF PF09581.5 ESA20415.1 - 0.37 10.6 5.9 0.42 10.4 4.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF972 PF06156.8 ESA20415.1 - 0.39 11.0 8.7 1.8 8.9 6.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Atg14 PF10186.4 ESA20415.1 - 0.46 9.3 7.5 0.56 9.1 5.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Shugoshin_N PF07558.6 ESA20415.1 - 0.8 9.4 5.1 0.42 10.3 1.1 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.10 ESA20415.1 - 0.96 8.9 9.7 1.3 8.5 2.7 2.3 2 0 0 2 2 2 0 Septum formation initiator TBPIP PF07106.8 ESA20415.1 - 1.1 8.8 11.2 1.8 8.0 7.7 1.3 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4446 PF14584.1 ESA20415.1 - 1.4 8.7 8.1 1.3 8.8 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) HAUS6_N PF14661.1 ESA20415.1 - 1.7 7.9 8.1 2.4 7.4 5.6 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Phage_GP20 PF06810.6 ESA20415.1 - 2.5 7.5 12.5 0.83 9.0 4.5 2.1 1 1 0 2 2 2 0 Phage minor structural protein GP20 Pkinase PF00069.20 ESA20416.1 - 3.7e-29 101.6 0.2 4.4e-29 101.4 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20416.1 - 1.4e-27 96.4 0.0 1.6e-27 96.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_J1 PF03338.10 ESA20416.1 - 0.00063 19.4 0.1 0.01 15.5 0.0 2.4 1 1 2 3 3 3 1 Poxvirus J1 protein APH PF01636.18 ESA20416.1 - 0.083 12.6 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA20418.1 - 3e-28 98.7 0.1 7.8e-28 97.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20418.1 - 3.5e-27 95.0 0.0 7.2e-27 94.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2004 PF09406.5 ESA20418.1 - 0.055 13.5 0.0 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2004) APH PF01636.18 ESA20418.1 - 0.098 12.3 0.1 0.35 10.5 0.1 1.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Myb_DNA-bind_6 PF13921.1 ESA20421.1 - 8.6e-17 61.0 2.8 1.7e-13 50.4 0.2 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA20421.1 - 2.8e-15 56.1 0.2 2.5e-06 27.4 0.0 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF440 PF04269.7 ESA20421.1 - 0.017 15.1 0.1 0.023 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF440 Myb_DNA-bind_5 PF13873.1 ESA20421.1 - 0.053 13.4 2.8 6.8 6.6 0.0 3.6 2 1 2 4 4 4 0 Myb/SANT-like DNA-binding domain Aldo_ket_red PF00248.16 ESA20423.1 - 9.4e-55 185.4 0.0 1.2e-54 185.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MtrF PF09472.5 ESA20424.1 - 0.18 11.0 0.0 0.6 9.3 0.0 1.9 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) YebF PF13995.1 ESA20424.1 - 0.24 11.4 3.1 1 9.4 0.1 2.6 2 0 0 2 2 2 0 YebF-like protein PP2C PF00481.16 ESA20425.1 - 1.3e-13 50.9 0.5 3.5e-07 29.8 0.0 2.1 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 ESA20425.1 - 0.0025 17.2 0.0 0.0031 16.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Dimer_Tnp_hAT PF05699.9 ESA20426.1 - 4.1e-11 42.3 0.1 1.1e-10 40.9 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF659 PF04937.10 ESA20426.1 - 0.0099 15.3 0.2 0.062 12.7 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF 659) Prolamin_like PF05617.6 ESA20426.1 - 0.033 14.2 1.0 0.23 11.6 0.4 2.5 2 0 0 2 2 2 0 Prolamin-like MULE PF10551.4 ESA20426.1 - 0.12 12.5 0.3 1.1 9.4 0.0 2.6 2 1 0 2 2 2 0 MULE transposase domain Sel1 PF08238.7 ESA20427.1 - 2.8e-48 161.2 9.2 1.2e-11 44.8 0.3 5.0 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA20427.1 - 0.00042 20.1 12.4 2.4 8.0 1.3 4.6 3 2 1 4 4 4 3 MIT (microtubule interacting and transport) domain TFIIB PF00382.14 ESA20427.1 - 0.0076 16.0 0.4 35 4.3 0.0 4.4 4 1 1 5 5 5 0 Transcription factor TFIIB repeat TPR_11 PF13414.1 ESA20427.1 - 0.026 14.1 17.2 1.7 8.3 1.4 3.9 1 1 3 4 4 4 0 TPR repeat TPR_16 PF13432.1 ESA20427.1 - 0.14 12.8 2.1 0.98 10.1 0.1 2.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA20427.1 - 1.2 8.9 4.1 5.6 6.7 0.0 3.5 3 1 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_6 PF13174.1 ESA20427.1 - 1.4 9.5 6.6 11 6.7 0.2 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat NSF PF02071.15 ESA20427.1 - 7 7.7 11.0 90 4.3 0.1 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Pkinase PF00069.20 ESA20428.1 - 2.5e-38 131.7 0.4 4e-38 131.0 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20428.1 - 6.6e-36 123.7 0.1 1e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20428.1 - 0.031 13.9 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDE_Tnp_ISAZ013 PF07592.6 ESA20429.1 - 1.6e-05 23.8 0.0 0.056 12.1 0.0 2.2 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain IpaD PF06511.6 ESA20429.1 - 0.045 12.7 2.4 0.086 11.8 1.7 1.4 1 0 0 1 1 1 0 Invasion plasmid antigen IpaD DDE_Tnp_ISAZ013 PF07592.6 ESA20431.1 - 1.2e-05 24.2 0.0 0.00014 20.7 0.0 2.1 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain zf-C2H2 PF00096.21 ESA20431.1 - 0.06 13.7 1.5 0.29 11.5 1.0 2.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2 PF00096.21 ESA20432.1 - 1.1 9.7 6.1 0.71 10.3 2.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Peptidase_S64 PF08192.6 ESA20433.1 - 5.7 5.1 7.2 6.4 4.9 5.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 Pkinase_Tyr PF07714.12 ESA20435.1 - 1.4e-36 125.9 0.0 3e-21 75.6 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA20435.1 - 6e-32 110.8 0.1 2e-28 99.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain DDE_Tnp_ISAZ013 PF07592.6 ESA20436.1 - 0.01 14.6 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DUF1802 PF08819.6 ESA20436.1 - 0.19 11.3 2.5 0.26 10.8 0.2 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1802) CAGE1 PF15066.1 ESA20436.1 - 1.5 7.1 4.8 1.5 7.1 1.6 1.9 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family Imm45 PF15603.1 ESA20438.1 - 0.085 13.0 2.2 1.3 9.1 0.2 2.5 1 1 1 2 2 2 0 Immunity protein 45 FA_desaturase PF00487.19 ESA20440.1 - 1.4e-26 93.4 18.6 1.9e-26 93.0 12.9 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 ESA20440.1 - 2.9e-05 23.2 0.1 6.1e-05 22.1 0.1 1.6 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Peptidase_MA_2 PF13485.1 ESA20440.1 - 0.015 15.3 0.0 1.7 8.6 0.0 2.4 2 0 0 2 2 2 0 Peptidase MA superfamily RNA_pol_I_A49 PF06870.7 ESA20441.1 - 0.017 13.7 0.0 0.021 13.4 0.0 1.1 1 0 0 1 1 1 0 A49-like RNA polymerase I associated factor Peptidase_S10 PF00450.17 ESA20444.1 - 4.7e-124 414.7 3.1 6.1e-124 414.3 2.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Pkinase PF00069.20 ESA20445.1 - 9.3e-39 133.1 0.0 1.3e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20445.1 - 9.8e-38 129.7 0.0 1.5e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA20445.1 - 4e-05 23.0 0.1 7.3e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA20445.1 - 0.001 18.3 0.3 0.002 17.4 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA20445.1 - 0.0012 18.6 0.0 0.042 13.5 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20445.1 - 0.01 14.8 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Uma2 PF05685.7 ESA20446.1 - 0.014 14.7 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Putative restriction endonuclease His_binding PF02098.11 ESA20447.1 - 0.36 10.6 4.2 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Tick histamine binding protein Sars6 PF12133.3 ESA20450.1 - 0.029 14.0 2.5 0.043 13.4 1.7 1.2 1 0 0 1 1 1 0 Open reading frame 6 from SARS coronavirus UvrD_C_2 PF13538.1 ESA20451.1 - 0.072 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 ESA20451.1 - 0.11 10.2 0.1 0.12 10.1 0.0 1.1 1 0 0 1 1 1 0 Helicase Sel1 PF08238.7 ESA20452.1 - 1.4e-38 130.4 2.4 2.1e-10 40.8 0.1 4.1 4 0 0 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ESA20452.1 - 0.0065 16.0 7.4 0.13 11.9 0.9 3.4 1 1 3 4 4 4 3 TPR repeat ANTAR PF03861.9 ESA20452.1 - 0.042 13.4 0.1 3.7 7.1 0.0 3.0 3 0 0 3 3 3 0 ANTAR domain TPR_12 PF13424.1 ESA20452.1 - 0.31 11.0 6.2 2.5 8.0 0.5 4.0 1 1 2 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 ESA20452.1 - 0.49 10.3 7.5 5.6 6.9 0.8 3.9 3 2 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF3684 PF12449.3 ESA20455.1 - 2.6e-27 94.8 0.4 3.1e-27 94.6 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) DUF261 PF03196.8 ESA20455.1 - 0.00044 20.2 0.5 0.00083 19.3 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF261 Sec63 PF02889.11 ESA20455.1 - 0.034 13.3 0.2 0.049 12.8 0.1 1.2 1 0 0 1 1 1 0 Sec63 Brl domain DUF4627 PF15425.1 ESA20458.1 - 2e-05 24.2 0.6 5.4e-05 22.7 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4627) Tubulin_C PF03953.12 ESA20458.1 - 0.007 16.4 0.3 0.007 16.4 0.2 2.7 3 0 0 3 3 3 1 Tubulin C-terminal domain RRM_6 PF14259.1 ESA20458.1 - 0.01 15.7 0.8 6.7 6.7 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Phage_30_3 PF08010.6 ESA20458.1 - 0.013 14.9 0.6 0.035 13.6 0.4 1.7 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 HSA PF07529.8 ESA20458.1 - 10 6.0 12.3 0.17 11.6 2.0 2.8 2 0 0 2 2 2 0 HSA Exo_endo_phos_2 PF14529.1 ESA20459.1 - 6.6e-06 25.7 0.4 1.9e-05 24.2 0.3 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Lentiviral_Tat PF02998.9 ESA20459.1 - 0.045 13.5 3.8 0.22 11.3 0.0 2.9 2 0 0 2 2 2 0 Lentiviral Tat protein Exo_endo_phos PF03372.18 ESA20459.1 - 0.063 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Carboxyl_trans PF01039.17 ESA20461.1 - 1.9e-118 395.9 0.0 2.4e-118 395.6 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain ECH PF00378.15 ESA20461.1 - 0.012 14.7 0.5 0.51 9.4 0.0 2.4 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase family Synaptonemal_3 PF15191.1 ESA20461.1 - 0.15 11.8 0.2 0.3 10.8 0.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 Rsd_AlgQ PF04353.8 ESA20463.1 - 0.0044 16.7 0.0 0.0062 16.2 0.0 1.2 1 0 0 1 1 1 1 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF1296 PF06972.6 ESA20463.1 - 0.042 13.8 0.1 0.092 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) DUF3723 PF12520.3 ESA20463.1 - 0.078 11.4 0.1 0.078 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) Phage_integrase PF00589.17 ESA20464.1 - 1.7e-05 24.5 0.1 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family DUF3504 PF12012.3 ESA20464.1 - 0.0063 16.3 0.5 0.018 14.8 0.4 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3504) Adeno_E3_14_5 PF04834.7 ESA20465.1 - 0.1 13.0 3.7 9.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Early E3 14.5 kDa protein zf-A20 PF01754.11 ESA20465.1 - 0.12 11.9 0.2 0.26 10.9 0.1 1.6 1 0 0 1 1 1 0 A20-like zinc finger TLD PF07534.11 ESA20469.1 - 0.00049 20.1 0.4 0.00053 19.9 0.2 1.0 1 0 0 1 1 1 1 TLD MMR_HSR1 PF01926.18 ESA20470.1 - 1.6e-07 31.2 0.4 4.3e-07 29.8 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA20470.1 - 4.2e-07 29.3 0.1 6.6e-07 28.6 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Hpr_kinase_C PF07475.7 ESA20470.1 - 0.0011 18.3 0.2 0.042 13.1 0.0 2.3 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain DUF258 PF03193.11 ESA20470.1 - 0.0049 16.0 0.1 0.011 14.9 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 ESA20470.1 - 0.0096 16.1 0.5 0.047 13.8 0.1 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 ESA20470.1 - 0.0098 16.1 0.8 0.022 15.0 0.5 1.8 1 1 0 1 1 1 1 ABC transporter Septin PF00735.13 ESA20470.1 - 0.016 14.1 0.2 0.054 12.4 0.0 1.9 2 0 0 2 2 2 0 Septin DUF87 PF01935.12 ESA20470.1 - 0.018 14.8 4.6 0.098 12.4 0.0 2.6 1 1 1 2 2 2 0 Domain of unknown function DUF87 Med15_fungi PF05397.7 ESA20470.1 - 0.036 14.0 2.1 0.14 12.0 0.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 15 FtsK_SpoIIIE PF01580.13 ESA20470.1 - 0.041 13.3 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF659 PF04937.10 ESA20470.1 - 0.043 13.2 0.6 0.1 12.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Dynamin_N PF00350.18 ESA20470.1 - 0.049 13.4 0.1 0.15 11.8 0.1 2.0 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.1 ESA20470.1 - 0.051 13.7 0.1 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 ESA20470.1 - 0.051 13.0 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 ESA20470.1 - 0.065 13.5 0.4 0.28 11.4 0.2 2.1 1 1 0 1 1 1 0 AAA domain Clr2 PF10383.4 ESA20470.1 - 0.085 12.8 0.1 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 Transcription-silencing protein Clr2 AAA_23 PF13476.1 ESA20470.1 - 0.087 13.1 6.5 0.54 10.5 4.8 2.0 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 ESA20470.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SE PF00437.15 ESA20470.1 - 0.13 11.1 0.0 0.25 10.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DER1 PF04511.10 ESA20473.1 - 5.5e-39 133.7 18.4 7.6e-39 133.2 12.7 1.2 1 0 0 1 1 1 1 Der1-like family Lipase_GDSL PF00657.17 ESA20474.1 - 3e-11 43.5 0.0 6.1e-11 42.5 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 ESA20474.1 - 5.3e-09 36.4 0.0 6e-08 33.0 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Glyco_hydro_1 PF00232.13 ESA20474.1 - 0.063 11.4 0.1 0.089 10.9 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Arch_ATPase PF01637.13 ESA20475.1 - 1.7e-10 40.9 0.7 2.3e-10 40.5 0.5 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA20475.1 - 1.6e-06 28.2 0.1 4.7e-06 26.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA20475.1 - 0.00021 21.4 0.0 0.00059 19.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 ESA20475.1 - 0.00053 20.1 0.0 0.0012 19.0 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 ESA20475.1 - 0.011 14.4 0.0 0.021 13.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus DUF815 PF05673.8 ESA20475.1 - 0.048 12.5 0.0 0.11 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.1 ESA20475.1 - 0.11 11.8 0.2 0.34 10.2 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.1 ESA20475.1 - 0.2 11.2 1.0 0.49 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain OCD_Mu_crystall PF02423.10 ESA20477.1 - 0.12 11.1 0.1 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Pex16 PF08610.5 ESA20477.1 - 2.4 7.0 6.9 4.6 6.1 4.8 1.5 1 1 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Chromo PF00385.19 ESA20478.1 - 1.8e-12 46.7 0.1 1.8e-12 46.7 0.0 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Pox_RNA_Pol_19 PF05320.7 ESA20478.1 - 4.5 6.9 9.0 16 5.2 3.2 2.1 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GATA PF00320.22 ESA20479.1 - 8.3e-10 37.8 1.3 1.3e-09 37.1 0.9 1.4 1 0 0 1 1 1 1 GATA zinc finger DUF2427 PF10348.4 ESA20480.1 - 2.4e-31 107.4 3.4 8.2e-30 102.4 0.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.11 ESA20480.1 - 3.2e-06 27.0 8.6 8.4e-06 25.6 6.0 1.6 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF897 PF05982.7 ESA20480.1 - 0.016 13.9 0.5 0.022 13.5 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF897) KdpC PF02669.10 ESA20480.1 - 0.024 14.3 0.2 0.039 13.6 0.2 1.3 1 0 0 1 1 1 0 K+-transporting ATPase, c chain VIT1 PF01988.14 ESA20480.1 - 0.18 11.2 5.7 0.63 9.4 2.0 2.3 1 1 1 2 2 2 0 VIT family Borrelia_P13 PF05628.7 ESA20480.1 - 0.23 11.2 3.1 0.19 11.5 0.8 1.7 1 1 0 1 1 1 0 Borrelia membrane protein P13 Glycos_transf_4 PF00953.16 ESA20480.1 - 0.3 10.8 4.7 0.11 12.3 0.5 2.0 1 1 1 2 2 2 0 Glycosyl transferase family 4 MatE PF01554.13 ESA20480.1 - 0.91 9.1 6.0 3.2 7.3 4.2 2.0 1 1 0 1 1 1 0 MatE DUF973 PF06157.6 ESA20480.1 - 7.1 5.5 13.0 14 4.5 6.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF973) DUF3402 PF11882.3 ESA20481.1 - 6.5e-125 417.3 13.4 8.9e-125 416.9 9.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) Pkinase PF00069.20 ESA20482.1 - 2.4e-74 249.7 0.0 3e-74 249.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20482.1 - 1.1e-32 113.1 0.0 1.5e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20482.1 - 0.00044 19.3 0.0 0.0013 17.7 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESA20482.1 - 0.00085 18.4 0.2 0.0016 17.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA20482.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family S_100 PF01023.14 ESA20482.1 - 0.073 12.3 0.4 0.27 10.6 0.2 1.9 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Actin PF00022.14 ESA20483.1 - 1.3e-90 303.7 0.0 1.5e-90 303.4 0.0 1.1 1 0 0 1 1 1 1 Actin zf-DHHC PF01529.15 ESA20484.1 - 4.5e-46 156.4 10.8 4.5e-46 156.4 7.5 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase FF PF01846.14 ESA20489.1 - 0.088 12.7 3.8 0.95 9.4 0.4 2.8 1 1 1 2 2 2 0 FF domain adh_short PF00106.20 ESA20491.1 - 0.0025 17.7 0.0 0.0035 17.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short PF00106.20 ESA20492.1 - 1e-18 67.8 0.0 1.7e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20492.1 - 3.4e-09 36.6 0.0 5.3e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA20492.1 - 0.0097 14.8 0.0 0.051 12.4 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 ESA20493.1 - 5.6e-18 65.4 0.0 7.7e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20493.1 - 7.3e-08 32.2 0.0 1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA20493.1 - 0.011 14.6 0.0 0.044 12.6 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF1379 PF07126.7 ESA20497.1 - 0.058 12.7 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1379) XkdW PF09636.5 ESA20498.1 - 0.0091 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 XkdW protein Fib_alpha PF08702.5 ESA20498.1 - 1.2 9.2 6.4 1.8 8.7 4.5 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF2263 PF10021.4 ESA20499.1 - 5.3e-21 75.1 0.0 9.8e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) p450 PF00067.17 ESA20500.1 - 3.9e-73 246.5 0.1 5.4e-73 246.0 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 IFT46_B_C PF12317.3 ESA20504.1 - 0.13 11.6 1.1 0.21 10.9 0.3 1.6 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal adh_short PF00106.20 ESA20505.1 - 4e-07 30.1 0.0 5.9e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DDE_Tnp_ISAZ013 PF07592.6 ESA20507.1 - 4.1e-06 25.7 0.5 9.8e-05 21.2 0.0 2.7 2 1 0 2 2 2 1 Rhodopirellula transposase DDE domain DDE_Tnp_ISAZ013 PF07592.6 ESA20508.1 - 0.0029 16.3 0.0 0.041 12.6 0.0 2.2 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain AT_hook PF02178.14 ESA20509.1 - 2.4 8.0 6.1 4.9 7.1 4.2 1.5 1 0 0 1 1 1 0 AT hook motif DDE_Tnp_ISAZ013 PF07592.6 ESA20510.1 - 0.00051 18.8 1.0 0.0065 15.2 0.0 2.6 2 1 0 2 2 2 1 Rhodopirellula transposase DDE domain Neogenin_C PF06583.7 ESA20511.1 - 0.16 11.5 1.7 0.17 11.4 1.1 1.0 1 0 0 1 1 1 0 Neogenin C-terminus Pkinase PF00069.20 ESA20512.1 - 1.7e-39 135.5 0.0 4.1e-39 134.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20512.1 - 3.3e-34 118.1 0.0 5.5e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20512.1 - 0.00019 21.2 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA20512.1 - 0.0002 20.7 2.2 0.00022 20.6 0.0 2.2 3 0 0 3 3 3 1 RIO1 family WaaY PF06176.6 ESA20512.1 - 0.0079 15.4 0.1 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA20512.1 - 0.034 13.1 0.0 0.065 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HIG_1_N PF04588.8 ESA20513.1 - 6.5e-06 25.7 1.1 1.3e-05 24.8 0.7 1.5 1 0 0 1 1 1 1 Hypoxia induced protein conserved region TctB PF07331.6 ESA20513.1 - 0.073 12.7 0.6 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Pkinase PF00069.20 ESA20515.1 - 6.6e-40 136.9 0.0 1.2e-39 136.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20515.1 - 2.4e-39 134.9 0.0 3.8e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20515.1 - 0.00023 20.9 0.0 0.00041 20.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA20515.1 - 0.022 14.1 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Stc1 PF12898.2 ESA20515.1 - 0.04 13.9 0.2 0.091 12.8 0.2 1.5 1 0 0 1 1 1 0 Stc1 domain RNA_Me_trans PF04252.8 ESA20517.1 - 2.8e-40 137.8 0.0 2.8e-39 134.5 0.0 1.9 1 1 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase tRNA_m1G_MT PF01746.16 ESA20517.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase ASXH PF13919.1 ESA20519.1 - 7.9e-08 32.1 1.0 7.9e-08 32.1 0.7 3.0 2 1 0 2 2 2 1 Asx homology domain VIGSSK PF14773.1 ESA20520.1 - 0.29 11.0 0.1 0.29 11.0 0.1 2.3 2 0 0 2 2 2 0 Helicase-associated putative binding domain, C-terminal F-box-like PF12937.2 ESA20522.1 - 0.00069 19.2 0.8 0.0016 18.0 0.5 1.7 1 0 0 1 1 1 1 F-box-like DUF4519 PF15012.1 ESA20523.1 - 1.7 8.6 5.9 8.6 6.3 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) HMG_box PF00505.14 ESA20524.1 - 8e-06 26.0 0.1 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA20524.1 - 0.013 15.8 0.1 0.02 15.2 0.1 1.3 1 0 0 1 1 1 0 HMG-box domain Dimer_Tnp_hAT PF05699.9 ESA20525.1 - 1e-14 53.8 0.0 1.1e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region FANCI_S4 PF14678.1 ESA20526.1 - 1.4e-53 181.6 5.5 3.8e-53 180.2 3.8 1.7 1 0 0 1 1 1 1 FANCI solenoid 4 FANCI_S1 PF14675.1 ESA20526.1 - 2.3e-39 135.0 0.6 7.3e-39 133.4 0.0 2.2 2 0 0 2 2 2 1 FANCI solenoid 1 FANCI_S2 PF14676.1 ESA20526.1 - 3.9e-39 134.0 2.6 3.9e-39 134.0 1.8 4.1 4 0 0 4 4 4 1 FANCI solenoid 2 FANCI_HD2 PF14680.1 ESA20526.1 - 3.8e-38 130.9 1.3 3.8e-38 130.9 0.9 2.5 3 0 0 3 3 3 1 FANCI helical domain 2 FANCI_S3 PF14677.1 ESA20526.1 - 8.4e-22 77.6 0.8 8.4e-22 77.6 0.6 2.8 3 0 0 3 3 3 1 FANCI solenoid 3 FANCI_HD1 PF14679.1 ESA20526.1 - 1.8e-19 69.2 1.0 3e-18 65.3 0.3 3.0 2 0 0 2 2 2 1 FANCI helical domain 1 Metallophos PF00149.23 ESA20527.1 - 1.6e-44 151.6 0.4 2.1e-44 151.3 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 ESA20527.1 - 0.0026 17.5 0.0 0.0057 16.4 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ThiF PF00899.16 ESA20528.1 - 1.4e-09 37.8 0.0 4.7e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 ThiF family DUF1126 PF06565.7 ESA20528.1 - 0.23 10.9 1.3 0.48 9.9 0.1 2.2 2 0 0 2 2 2 0 Repeat of unknown function (DUF1126) Clp1 PF06807.9 ESA20529.1 - 8e-42 143.2 0.0 1.2e-41 142.6 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 ESA20529.1 - 2.6e-13 49.8 0.0 4.8e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_35 PF14516.1 ESA20529.1 - 0.0011 17.6 0.0 0.0018 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain AAA_24 PF13479.1 ESA20529.1 - 0.0031 17.1 0.0 0.0079 15.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA20529.1 - 0.018 14.9 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 ESA20529.1 - 0.037 13.9 0.0 0.15 12.0 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 ESA20529.1 - 0.042 13.8 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Transcrip_reg PF01709.15 ESA20529.1 - 0.043 12.9 0.0 0.074 12.1 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator SRPRB PF09439.5 ESA20529.1 - 0.062 12.5 0.0 0.25 10.5 0.0 2.0 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit RuvB_N PF05496.7 ESA20529.1 - 0.097 11.7 0.0 0.21 10.6 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus DDE_1 PF03184.14 ESA20530.1 - 8.7e-11 41.3 0.1 9e-11 41.3 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Gate PF07670.9 ESA20531.1 - 3.7 7.5 7.3 4.8 7.1 5.1 1.3 1 1 0 1 1 1 0 Nucleoside recognition Abi PF02517.11 ESA20531.1 - 5.7 7.1 8.0 17 5.5 5.5 1.8 1 1 0 1 1 1 0 CAAX protease self-immunity Ribonuc_red_lgC PF02867.10 ESA20533.1 - 2.1e-212 706.4 0.1 2.9e-212 706.0 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 ESA20533.1 - 3.8e-24 84.2 0.0 8.8e-24 83.1 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 ESA20533.1 - 3.1e-17 62.8 0.1 1.4e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 ESA20533.1 - 0.0029 15.7 0.3 0.0044 15.1 0.2 1.2 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Nucleoporin_C PF03177.9 ESA20534.1 - 1.5e-40 139.3 30.4 1.5e-40 139.3 21.1 1.6 2 0 0 2 2 2 1 Non-repetitive/WGA-negative nucleoporin C-terminal AT_hook PF02178.14 ESA20535.1 - 2.1 8.2 6.2 5.1 7.1 4.3 1.7 1 0 0 1 1 1 0 AT hook motif BTB PF00651.26 ESA20536.1 - 9.9e-18 64.1 0.5 1.4e-17 63.6 0.4 1.2 1 0 0 1 1 1 1 BTB/POZ domain Urm1 PF09138.6 ESA20536.1 - 4.6e-05 23.4 2.5 0.2 11.8 0.2 2.4 1 1 1 2 2 2 2 Urm1 (Ubiquitin related modifier) CEP44 PF15007.1 ESA20536.1 - 0.068 12.8 0.2 0.13 11.9 0.2 1.5 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 RPAP3_C PF13877.1 ESA20536.1 - 0.11 12.4 2.3 1.2 9.1 0.1 2.3 1 1 1 2 2 2 0 Potential Monad-binding region of RPAP3 F-box-like PF12937.2 ESA20537.1 - 0.047 13.4 0.3 0.047 13.4 0.2 2.7 3 0 0 3 3 3 0 F-box-like FLYWCH PF04500.11 ESA20537.1 - 0.083 12.7 0.0 0.56 10.1 0.0 2.3 2 0 0 2 2 2 0 FLYWCH zinc finger domain DUF1844 PF08899.6 ESA20537.1 - 0.097 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) LRR_4 PF12799.2 ESA20537.1 - 8 6.2 7.9 7.6 6.2 0.0 4.1 3 3 0 3 3 3 0 Leucine Rich repeats (2 copies) DNA_pol_B PF00136.16 ESA20538.1 - 5.1e-37 127.7 0.6 8.2e-37 127.0 0.2 1.3 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B PF00136.16 ESA20539.1 - 1.1e-45 156.2 4.3 1.4e-45 155.9 3.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DUF310 PF03750.8 ESA20539.1 - 0.029 14.5 3.1 1.3 9.2 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF310) Hormone_6 PF00236.13 ESA20539.1 - 0.074 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycoprotein hormone DNA_pol_B PF00136.16 ESA20540.1 - 5.4e-39 134.2 0.4 2.3e-36 125.5 0.1 2.4 1 1 1 2 2 2 2 DNA polymerase family B AAA-ATPase_like PF09820.4 ESA20541.1 - 6.6e-32 110.8 11.5 1.7e-31 109.4 8.0 1.7 1 0 0 1 1 1 1 Predicted AAA-ATPase DUF1703 PF08011.6 ESA20541.1 - 6.9e-13 48.2 0.1 1.8e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1703) RasGAP PF00616.14 ESA20542.1 - 0.0025 17.5 3.2 0.0041 16.8 2.2 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase YqgF PF14639.1 ESA20542.1 - 0.011 15.3 0.7 0.019 14.5 0.5 1.3 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Phage_Gp15 PF06854.6 ESA20543.1 - 0.16 11.5 6.4 0.046 13.2 1.0 2.1 2 0 0 2 2 2 0 Bacteriophage Gp15 protein DUF2712 PF10916.3 ESA20544.1 - 0.12 12.3 0.2 0.16 11.9 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2712) EF-hand_1 PF00036.27 ESA20547.1 - 1.4e-13 49.0 7.6 0.00048 19.2 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 ESA20547.1 - 3.3e-11 43.1 5.4 1.4e-06 28.3 3.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 ESA20547.1 - 2.1e-10 39.5 5.0 0.0021 17.7 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 ESA20547.1 - 8.4e-10 38.1 6.6 0.01 15.4 0.1 3.5 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 ESA20547.1 - 1.8e-05 23.8 6.9 0.013 14.8 0.1 3.9 3 1 0 3 3 3 2 EF hand EF-hand_4 PF12763.2 ESA20547.1 - 0.005 16.5 2.1 1.6 8.5 0.0 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA20547.1 - 0.13 12.3 0.3 19 5.3 0.0 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FAR1 PF03101.10 ESA20551.1 - 2.6e-08 34.2 0.7 4.2e-08 33.5 0.5 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Pkinase PF00069.20 ESA20552.1 - 1.1e-27 96.7 0.0 2.3e-27 95.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20552.1 - 1.7e-27 96.1 0.0 4.4e-27 94.7 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1424 PF07232.6 ESA20552.1 - 0.1 11.3 0.0 0.58 8.8 0.0 2.0 2 0 0 2 2 2 0 Putative rep protein (DUF1424) Sel1 PF08238.7 ESA20553.1 - 4e-11 43.1 11.9 3.8e-06 27.3 0.2 3.9 4 0 0 4 4 4 2 Sel1 repeat Pkinase PF00069.20 ESA20553.1 - 0.0018 17.4 0.0 0.0036 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_11 PF13414.1 ESA20553.1 - 0.046 13.3 11.7 2.6 7.7 0.3 3.2 2 1 1 3 3 3 0 TPR repeat Pkinase_Tyr PF07714.12 ESA20553.1 - 0.065 12.2 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase TPR_17 PF13431.1 ESA20553.1 - 0.46 10.8 2.4 0.74 10.1 0.1 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA20553.1 - 0.59 10.1 6.9 7.5 6.7 0.1 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA20553.1 - 1.3 8.7 5.4 5.3 6.8 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA20554.1 - 0.016 14.9 0.2 0.019 14.7 0.1 1.1 1 0 0 1 1 1 0 F-box-like Sp38 PF07354.7 ESA20554.1 - 0.13 10.9 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) PA26 PF04636.8 ESA20555.1 - 0.0095 14.6 1.5 3.2 6.3 0.0 2.0 1 1 1 2 2 2 2 PA26 p53-induced protein (sestrin) PT PF04886.7 ESA20555.1 - 2.1 7.7 16.1 0.027 13.7 3.1 3.0 3 0 0 3 3 3 0 PT repeat FoP_duplication PF13865.1 ESA20555.1 - 9.1 6.8 9.1 20 5.7 6.3 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 EF-hand_1 PF00036.27 ESA20556.1 - 1.7e-81 261.4 115.4 0.00019 20.5 2.1 20.9 20 0 0 20 20 20 20 EF hand EF-hand_7 PF13499.1 ESA20556.1 - 1.1e-73 243.2 100.3 1.8e-08 34.3 2.7 15.7 9 6 7 16 16 16 16 EF-hand domain pair EF-hand_6 PF13405.1 ESA20556.1 - 8.3e-63 202.6 102.3 0.002 17.8 0.1 21.6 22 0 0 22 22 22 19 EF-hand domain EF-hand_8 PF13833.1 ESA20556.1 - 4.4e-46 154.3 95.8 4.5e-07 29.3 1.5 20.1 11 5 9 20 20 20 19 EF-hand domain pair EF-hand_5 PF13202.1 ESA20556.1 - 2.6e-36 121.3 112.1 0.011 15.0 0.1 22.5 23 0 0 23 23 23 15 EF hand SPARC_Ca_bdg PF10591.4 ESA20556.1 - 1.1e-23 83.4 37.3 0.0016 18.4 0.0 11.9 10 2 3 13 13 13 9 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 ESA20556.1 - 2.8e-21 75.2 57.9 0.05 13.3 0.0 15.9 6 5 10 16 16 16 10 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 ESA20556.1 - 7.5e-06 25.5 43.5 1.1 8.9 0.0 13.2 10 4 4 14 14 14 5 EF hand DUF3874 PF12990.2 ESA20556.1 - 0.0046 17.0 0.1 1.6e+02 2.5 0.0 4.9 5 0 0 5 5 5 0 Domain of unknonw function from B. Theta Gene description (DUF3874) DUF2520 PF10728.4 ESA20556.1 - 0.018 14.4 0.2 1.5 8.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2520) SapB_2 PF03489.12 ESA20558.1 - 0.077 13.0 0.3 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 2 BTB PF00651.26 ESA20559.1 - 5e-18 65.1 0.1 1.2e-17 63.8 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20559.1 - 8.7e-14 51.6 2.8 3.1e-12 46.6 0.7 3.2 2 1 0 2 2 2 1 TLD Urm1 PF09138.6 ESA20559.1 - 0.072 13.2 1.7 0.55 10.3 0.2 2.8 1 1 1 2 2 2 0 Urm1 (Ubiquitin related modifier) BACK PF07707.10 ESA20559.1 - 0.1 12.4 3.5 0.25 11.2 1.0 2.7 2 1 0 2 2 2 0 BTB And C-terminal Kelch HTH_23 PF13384.1 ESA20560.1 - 2.4e-10 39.7 0.4 3.8e-10 39.0 0.3 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA20560.1 - 0.00013 22.0 0.0 0.00015 21.8 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 ESA20560.1 - 0.00056 19.8 0.1 0.00073 19.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain CENP-B_N PF04218.8 ESA20560.1 - 0.00056 19.2 0.0 0.00094 18.5 0.0 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_7 PF02796.10 ESA20560.1 - 0.00092 19.0 0.0 0.004 16.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase PAX PF00292.13 ESA20560.1 - 0.0031 17.2 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_ISL3 PF13542.1 ESA20560.1 - 0.0056 15.8 0.0 0.009 15.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 Terminase_5 PF06056.7 ESA20560.1 - 0.0071 15.8 0.2 0.0098 15.4 0.1 1.3 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) GerE PF00196.14 ESA20560.1 - 0.0089 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.7 ESA20560.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_1 PF01527.15 ESA20560.1 - 0.033 14.1 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 Transposase HTH_38 PF13936.1 ESA20560.1 - 0.059 12.9 0.2 0.1 12.1 0.0 1.5 2 0 0 2 2 2 0 Helix-turn-helix domain FeoC PF09012.5 ESA20560.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 FeoC like transcriptional regulator Sel1 PF08238.7 ESA20561.1 - 4.2e-46 154.3 2.8 6.7e-12 45.6 0.1 5.4 5 1 0 5 5 5 5 Sel1 repeat Flu_M1_C PF08289.6 ESA20561.1 - 0.13 12.3 0.1 0.36 10.8 0.0 1.8 2 1 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain RNase_P_p30 PF01876.11 ESA20561.1 - 0.14 11.3 0.1 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 RNase P subunit p30 MIT PF04212.13 ESA20561.1 - 1.3 9.0 12.1 2.2 8.2 1.2 3.7 2 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 ESA20561.1 - 1.3 9.9 3.9 1.4e+02 3.8 0.1 4.0 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_12 PF13424.1 ESA20561.1 - 2.9 7.8 5.7 11 6.0 1.0 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF2325 PF10087.4 ESA20564.1 - 0.015 15.0 1.6 0.042 13.6 0.1 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) ETS_PEA3_N PF04621.8 ESA20568.1 - 0.026 13.7 6.0 0.033 13.4 4.2 1.1 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain ABC2_membrane_3 PF12698.2 ESA20568.1 - 5.7 5.8 10.7 6.2 5.7 7.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein BTB PF00651.26 ESA20569.1 - 4.7e-20 71.6 0.5 1.1e-19 70.4 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA20569.1 - 8.4e-09 35.5 1.6 2e-08 34.3 1.1 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20569.1 - 1.7e-05 24.5 0.2 0.00041 20.1 0.0 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA20569.1 - 0.035 13.2 0.5 0.057 12.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) TLD PF07534.11 ESA20570.1 - 3.3e-08 33.6 1.1 3.8e-08 33.4 0.8 1.1 1 0 0 1 1 1 1 TLD DUF2711 PF10924.3 ESA20571.1 - 0.011 15.2 0.3 0.017 14.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2711) HSP70 PF00012.15 ESA20572.1 - 1.1e-25 89.6 0.0 1.2e-25 89.5 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein HSP70 PF00012.15 ESA20573.1 - 4.1e-177 589.7 4.3 4.5e-177 589.6 3.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA20573.1 - 1.3e-16 60.1 0.1 1.6e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 ESA20573.1 - 0.013 14.5 1.0 0.45 9.5 0.0 2.9 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase DDR PF08841.5 ESA20573.1 - 0.015 14.1 0.2 0.18 10.5 0.0 2.3 2 1 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain ATG19_autophagy PF12744.2 ESA20573.1 - 0.018 14.3 3.0 0.037 13.2 1.9 1.7 1 1 1 2 2 2 0 Autophagy protein Atg19, Atg8-binding FGGY_C PF02782.11 ESA20573.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF1843 PF08898.5 ESA20573.1 - 0.51 10.4 2.7 2.3 8.3 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) FtsA PF14450.1 ESA20573.1 - 1.7 8.5 4.7 5.4 6.8 0.1 3.0 2 1 0 2 2 2 0 Cell division protein FtsA TDH PF03347.8 ESA20574.1 - 0.017 14.7 0.2 0.036 13.6 0.1 1.6 2 0 0 2 2 2 0 Vibrio thermostable direct hemolysin Nucleoplasmin PF03066.10 ESA20575.1 - 2.1 7.8 9.3 3.4 7.1 6.4 1.5 1 0 0 1 1 1 0 Nucleoplasmin DUF2508 PF10704.4 ESA20576.1 - 0.31 11.2 0.1 0.31 11.2 0.1 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2508) GrpE PF01025.14 ESA20576.1 - 0.43 10.1 9.2 0.18 11.2 4.7 1.6 1 1 1 2 2 2 0 GrpE DUF4162 PF13732.1 ESA20576.1 - 0.91 10.0 8.3 0.11 13.0 1.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4162) Cas_Cas6 PF01881.11 ESA20578.1 - 0.095 12.9 0.0 0.11 12.7 0.0 1.0 1 0 0 1 1 1 0 CRISPR associated protein Cas6 NAS PF03059.11 ESA20579.1 - 0.082 12.0 0.1 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein DUF2969 PF11184.3 ESA20579.1 - 0.1 12.7 2.1 0.11 12.6 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2969) HLH PF00010.21 ESA20580.1 - 2.1e-12 46.5 1.5 3.3e-12 45.9 0.3 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SART-1 PF03343.8 ESA20580.1 - 0.0024 16.2 9.6 0.0024 16.2 6.6 1.6 2 0 0 2 2 2 1 SART-1 family DUF3166 PF11365.3 ESA20580.1 - 0.0033 17.8 0.8 0.0069 16.8 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3166) Phage_lysis PF03245.8 ESA20580.1 - 0.0044 17.0 0.1 0.0044 17.0 0.0 2.0 2 0 0 2 2 2 1 Bacteriophage Rz lysis protein Glycohydro_20b2 PF14845.1 ESA20580.1 - 0.018 15.6 8.5 0.14 12.7 5.9 2.1 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like DUF4407 PF14362.1 ESA20580.1 - 4 6.3 7.6 5.6 5.8 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HALZ PF02183.13 ESA20580.1 - 4.6 7.0 6.9 0.33 10.7 1.0 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF1861 PF08950.5 ESA20581.1 - 0.066 12.0 0.0 0.07 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) Pkinase_Tyr PF07714.12 ESA20585.1 - 0.0013 17.8 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Lentiviral_Tat PF02998.9 ESA20586.1 - 0.002 17.8 0.2 0.0044 16.8 0.1 1.5 1 0 0 1 1 1 1 Lentiviral Tat protein Phe_ZIP PF08916.6 ESA20586.1 - 0.14 12.5 0.2 0.41 11.0 0.2 1.7 1 0 0 1 1 1 0 Phenylalanine zipper Sel1 PF08238.7 ESA20587.1 - 8.1e-79 258.3 24.4 3.4e-12 46.5 0.2 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA20587.1 - 0.0018 18.6 15.5 2.4 8.8 0.1 6.3 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 ESA20587.1 - 0.0044 16.7 1.1 21 5.2 0.0 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA20587.1 - 0.0065 16.0 26.7 0.57 9.8 1.1 5.7 3 3 3 6 6 6 4 TPR repeat TSCPD PF12637.2 ESA20587.1 - 0.042 13.7 0.5 7.7 6.5 0.0 4.2 4 1 1 5 5 5 0 TSCPD domain TPR_16 PF13432.1 ESA20587.1 - 0.063 13.9 6.6 5.9 7.6 0.1 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA20587.1 - 0.088 13.4 0.0 39 5.2 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA20587.1 - 0.1 12.7 2.3 11 6.2 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA20587.1 - 0.22 11.8 11.2 8.1 6.8 0.1 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA20587.1 - 0.35 10.7 15.6 6.4 6.7 0.0 5.6 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 ESA20587.1 - 2.8 7.8 21.1 23 4.9 1.0 6.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA20587.1 - 6.5 7.2 24.3 19 5.7 1.3 6.8 6 3 1 7 7 7 0 Tetratricopeptide repeat AAA_21 PF13304.1 ESA20588.1 - 1.5 8.6 11.8 1.9 8.3 8.2 1.3 1 0 0 1 1 1 0 AAA domain Membralin PF09746.4 ESA20588.1 - 4.8 6.1 10.5 6.3 5.7 7.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein TLD PF07534.11 ESA20590.1 - 3.1e-08 33.7 0.1 3.9e-06 26.8 0.1 2.3 1 1 0 1 1 1 1 TLD Fis1_TPR_C PF14853.1 ESA20591.1 - 0.1 12.5 0.3 0.34 10.8 0.0 2.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Fer4_12 PF13353.1 ESA20591.1 - 8.5 6.4 17.5 1.2 9.2 5.7 2.3 1 1 1 2 2 2 0 4Fe-4S single cluster domain Pkinase_Tyr PF07714.12 ESA20592.1 - 0.034 13.2 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.20 ESA20592.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain zf-BED PF02892.10 ESA20593.1 - 1.9e-09 37.1 6.3 2.8e-09 36.5 4.3 1.3 1 0 0 1 1 1 1 BED zinc finger zf-FCS PF06467.9 ESA20593.1 - 0.011 15.3 0.4 0.024 14.2 0.3 1.6 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif BIR PF00653.16 ESA20593.1 - 0.046 14.1 0.5 0.087 13.2 0.4 1.5 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain Cytochrome-c551 PF10643.4 ESA20593.1 - 0.15 11.3 0.7 0.17 11.1 0.5 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 MUG113 PF13455.1 ESA20596.1 - 0.00071 19.9 0.5 0.0023 18.3 0.1 2.1 2 1 0 2 2 2 1 Meiotically up-regulated gene 113 T5orf172 PF10544.4 ESA20596.1 - 0.00095 19.5 0.2 0.0064 16.8 0.0 2.2 2 0 0 2 2 2 1 T5orf172 domain DBINO PF13892.1 ESA20597.1 - 0.0057 16.6 9.8 0.0071 16.3 2.7 2.6 2 1 1 3 3 3 1 DNA-binding domain AAA_assoc PF14363.1 ESA20597.1 - 0.019 14.9 0.5 7.4 6.7 0.1 2.6 1 1 0 2 2 2 0 Domain associated at C-terminal with AAA MULE PF10551.4 ESA20598.1 - 2.6e-07 30.7 0.4 1.1e-06 28.7 0.0 2.3 2 1 0 2 2 2 1 MULE transposase domain FAR1 PF03101.10 ESA20598.1 - 4.2e-05 23.9 0.5 0.00012 22.5 0.4 1.8 1 0 0 1 1 1 1 FAR1 DNA-binding domain RhoGAP PF00620.22 ESA20598.1 - 0.0037 16.8 0.5 0.0095 15.5 0.4 1.7 1 0 0 1 1 1 1 RhoGAP domain Transposase_mut PF00872.13 ESA20598.1 - 0.096 11.2 0.0 0.21 10.1 0.0 1.5 1 0 0 1 1 1 0 Transposase, Mutator family Rubis-subs-bind PF09273.6 ESA20598.1 - 0.11 12.4 1.4 3 7.7 0.0 2.4 1 1 1 2 2 2 0 Rubisco LSMT substrate-binding RicinB_lectin_2 PF14200.1 ESA20600.1 - 0.019 15.3 1.0 0.24 11.7 0.7 2.5 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like PadR PF03551.9 ESA20600.1 - 0.051 13.3 0.0 14 5.5 0.0 2.6 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family DnaJ PF00226.26 ESA20601.1 - 4e-12 45.6 0.3 8.3e-12 44.6 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain COX6C PF02937.10 ESA20601.1 - 0.047 13.5 0.4 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc Myb_DNA-binding PF00249.26 ESA20602.1 - 7.6e-05 22.6 0.0 0.0003 20.7 0.0 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain CMV_1a PF12467.3 ESA20602.1 - 6.8 7.0 29.2 0.38 11.0 0.3 3.1 1 1 2 3 3 3 0 Cucumber mosaic virus 1a protein family Ribosomal_S7 PF00177.16 ESA20603.1 - 1e-33 116.0 2.4 1.8e-33 115.1 1.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e YfdX PF10938.3 ESA20603.1 - 0.008 15.8 0.5 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 YfdX protein MRP-L20 PF12824.2 ESA20604.1 - 2.5e-28 99.1 4.1 2.9e-28 98.8 2.8 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.6 ESA20604.1 - 0.017 14.9 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Neugrin TauD PF02668.11 ESA20605.1 - 2e-40 139.0 0.0 3e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 ESA20605.1 - 8.4e-07 29.3 0.0 1.6e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.5 ESA20605.1 - 0.00034 19.6 0.1 0.012 14.4 0.0 2.3 2 0 0 2 2 2 1 CsiD 2OG-FeII_Oxy_3 PF13640.1 ESA20605.1 - 0.054 14.0 0.1 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily EF-hand_10 PF14788.1 ESA20605.1 - 0.1 12.3 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 EF hand BTB PF00651.26 ESA20606.1 - 1.3e-15 57.3 0.2 3.4e-15 55.9 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA20606.1 - 2.7e-13 50.1 0.3 7.7e-13 48.6 0.2 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20606.1 - 0.003 17.3 2.3 0.0062 16.3 0.2 2.4 2 1 1 3 3 3 1 BTB And C-terminal Kelch F-box-like PF12937.2 ESA20607.1 - 1.8e-06 27.5 0.3 3.9e-06 26.5 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA20607.1 - 1.7e-05 24.3 1.7 2.4e-05 23.8 0.1 2.1 2 0 0 2 2 2 1 F-box domain DUF641 PF04859.7 ESA20608.1 - 0.0017 18.1 1.2 0.0017 18.1 0.8 2.6 1 1 0 2 2 2 1 Plant protein of unknown function (DUF641) DUF2730 PF10805.3 ESA20608.1 - 0.01 15.5 2.0 0.01 15.5 1.4 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) HALZ PF02183.13 ESA20608.1 - 0.016 14.9 24.6 0.34 10.6 0.6 4.7 3 2 2 5 5 5 0 Homeobox associated leucine zipper DivIC PF04977.10 ESA20608.1 - 0.045 13.2 32.0 0.24 10.8 1.1 4.7 1 1 3 4 4 4 0 Septum formation initiator CCDC155 PF14662.1 ESA20608.1 - 0.065 12.8 34.0 0.21 11.1 13.6 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 DUF904 PF06005.7 ESA20608.1 - 0.13 12.5 41.3 0.43 10.9 8.0 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF904) bZIP_2 PF07716.10 ESA20608.1 - 0.23 11.3 26.1 1.6 8.6 2.3 5.2 4 3 1 5 5 5 0 Basic region leucine zipper bZIP_1 PF00170.16 ESA20608.1 - 0.27 11.2 36.8 0.75 9.8 2.1 4.9 3 1 2 5 5 5 0 bZIP transcription factor Cep57_CLD_2 PF14197.1 ESA20608.1 - 0.28 11.1 25.6 0.62 10.0 6.6 3.5 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Rab5-bind PF09311.6 ESA20608.1 - 0.28 11.0 28.6 0.28 11.0 12.7 3.5 1 1 2 3 3 3 0 Rabaptin-like protein GAS PF13851.1 ESA20608.1 - 0.49 9.5 37.8 0.027 13.6 8.9 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Taxilin PF09728.4 ESA20608.1 - 0.65 9.0 34.7 1.7 7.6 24.0 1.6 1 1 0 1 1 1 0 Myosin-like coiled-coil protein Filament PF00038.16 ESA20608.1 - 0.7 9.3 26.1 0.081 12.3 13.6 2.2 1 1 1 2 2 2 0 Intermediate filament protein Z1 PF10593.4 ESA20608.1 - 1.1 8.4 13.5 0.042 13.0 3.6 2.4 1 1 2 3 3 3 0 Z1 domain DUF2935 PF11155.3 ESA20608.1 - 1.2 9.2 22.9 18 5.4 5.9 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF2205 PF10224.4 ESA20608.1 - 1.3 8.6 26.2 0.034 13.7 3.3 4.3 1 1 4 5 5 5 0 Predicted coiled-coil protein (DUF2205) Ax_dynein_light PF10211.4 ESA20608.1 - 1.5 8.6 33.5 0.58 9.9 6.2 3.4 1 1 2 4 4 4 0 Axonemal dynein light chain DUF972 PF06156.8 ESA20608.1 - 1.5 9.1 30.7 0.99 9.7 4.6 3.8 1 1 2 3 3 3 0 Protein of unknown function (DUF972) TBPIP PF07106.8 ESA20608.1 - 5 6.6 36.4 6.2 6.3 13.9 2.3 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CorA PF01544.13 ESA20608.1 - 6.8 5.6 13.4 23 3.8 9.2 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3810 PF12725.2 ESA20608.1 - 7.6 5.3 16.6 3.6 6.3 4.5 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3810) TMCO5 PF14992.1 ESA20608.1 - 9.9 5.2 31.5 5.6 6.0 7.1 2.2 1 1 1 2 2 2 0 TMCO5 family DnaJ PF00226.26 ESA20609.1 - 0.036 13.7 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 DnaJ domain RicinB_lectin_2 PF14200.1 ESA20611.1 - 4.2e-07 30.2 3.9 7.2e-06 26.3 0.4 2.7 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like EXS PF03124.9 ESA20612.1 - 1e-60 205.6 17.1 1.2e-60 205.3 11.8 1.1 1 0 0 1 1 1 1 EXS family Scm3 PF10384.4 ESA20613.1 - 0.25 10.8 5.4 3.1 7.3 3.8 2.5 1 1 0 1 1 1 0 Centromere protein Scm3 Sel1 PF08238.7 ESA20614.1 - 1.4e-12 47.7 11.7 3.4e-05 24.3 0.1 5.2 5 0 0 5 5 5 3 Sel1 repeat TPR_17 PF13431.1 ESA20614.1 - 0.0047 17.0 3.5 0.83 10.0 0.2 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat FAST_1 PF06743.10 ESA20614.1 - 0.036 13.7 0.0 0.54 10.0 0.0 2.5 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 TPR_11 PF13414.1 ESA20614.1 - 0.32 10.6 11.6 0.19 11.3 2.3 3.3 3 1 1 4 4 4 0 TPR repeat TPR_8 PF13181.1 ESA20614.1 - 1.7 8.6 9.2 3.7 7.5 3.2 3.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Lsm_interact PF05391.6 ESA20615.1 - 0.01 15.2 1.3 2.6 7.6 0.2 2.9 2 0 0 2 2 2 0 Lsm interaction motif GlutR_N PF05201.10 ESA20616.1 - 0.01 15.4 1.6 0.036 13.6 1.1 2.0 1 1 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain XH PF03469.9 ESA20616.1 - 0.015 14.9 0.1 0.015 14.9 0.0 2.9 2 2 1 3 3 3 0 XH domain DUF1732 PF08340.6 ESA20616.1 - 0.047 13.5 1.5 0.13 12.0 1.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1732) DUF3584 PF12128.3 ESA20616.1 - 0.066 10.5 16.4 0.0038 14.6 7.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Phytochelatin PF05023.9 ESA20616.1 - 0.097 11.6 2.8 0.046 12.6 0.3 1.7 2 1 0 2 2 2 0 Phytochelatin synthase Apolipoprotein PF01442.13 ESA20616.1 - 0.12 11.8 9.4 0.17 11.4 6.3 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HlyD PF00529.15 ESA20616.1 - 0.32 10.2 2.9 0.91 8.7 2.0 1.7 1 1 0 1 1 1 0 HlyD family secretion protein Sugarporin_N PF11471.3 ESA20616.1 - 0.38 10.4 21.3 0.21 11.2 2.1 3.8 1 1 3 4 4 4 0 Maltoporin periplasmic N-terminal extension DUF4201 PF13870.1 ESA20616.1 - 1.3 8.4 21.0 0.016 14.6 4.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.6 ESA20616.1 - 1.5 7.4 20.9 1.3 7.6 13.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.7 ESA20616.1 - 1.8 8.2 13.5 5.8 6.6 6.8 2.6 1 1 1 2 2 2 0 Laminin Domain II Cauli_DNA-bind PF03310.8 ESA20616.1 - 2.4 8.0 12.1 5.1 6.9 3.6 3.1 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein DUF1664 PF07889.7 ESA20616.1 - 3.4 7.4 12.3 4.6 7.0 2.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Sec3_C_2 PF15278.1 ESA20616.1 - 3.6 7.7 6.9 4.1 7.6 0.6 3.2 2 1 1 3 3 3 0 Sec3 exocyst complex subunit DUF2203 PF09969.4 ESA20616.1 - 4.4 7.5 8.1 1.1e+02 3.0 5.6 2.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF2730 PF10805.3 ESA20616.1 - 5.4 6.8 9.7 19 5.0 0.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.7 ESA20616.1 - 5.4 6.8 9.0 3.8 7.3 2.9 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF342 PF03961.8 ESA20616.1 - 6.3 5.1 21.5 0.16 10.3 9.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF342) SAB PF04382.8 ESA20616.1 - 6.4 6.5 13.3 13 5.5 4.1 2.7 2 0 0 2 2 2 0 SAB domain DivIC PF04977.10 ESA20616.1 - 6.6 6.2 11.1 10 5.6 3.3 2.5 1 1 1 2 2 2 0 Septum formation initiator YlqD PF11068.3 ESA20616.1 - 6.6 6.7 12.9 0.1 12.6 0.7 2.8 1 1 2 3 3 3 0 YlqD protein DUF1703 PF08011.6 ESA20616.1 - 7.5 6.3 8.2 0.21 11.3 0.2 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF1703) Peptidase_M15_2 PF05951.8 ESA20618.1 - 0.082 12.3 0.0 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) Glutaredoxin2_C PF04399.8 ESA20620.1 - 0.014 14.9 3.1 0.03 13.8 2.2 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain IATP PF04568.7 ESA20620.1 - 0.018 15.0 8.8 0.051 13.6 6.1 1.8 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Endonuc_Holl PF10107.4 ESA20620.1 - 0.026 14.1 2.7 0.046 13.4 1.9 1.4 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase UPF0449 PF15136.1 ESA20620.1 - 0.094 12.9 8.6 0.04 14.1 4.3 1.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Med9 PF07544.8 ESA20620.1 - 0.19 11.4 5.7 13 5.5 2.7 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF641 PF04859.7 ESA20620.1 - 0.35 10.6 8.3 0.39 10.4 4.5 1.9 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) IncA PF04156.9 ESA20620.1 - 0.35 10.4 5.0 0.49 9.9 3.5 1.3 1 0 0 1 1 1 0 IncA protein Spc24 PF08286.6 ESA20620.1 - 0.67 9.6 12.1 2.2 8.0 7.6 2.2 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 DUF4407 PF14362.1 ESA20620.1 - 4.3 6.2 5.6 6 5.7 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.4 ESA20620.1 - 6.3 6.7 11.1 1.1 9.1 3.8 2.3 2 0 0 2 2 2 0 Haemolysin XhlA zf-C2H2_jaz PF12171.3 ESA20621.1 - 0.034 14.2 0.3 0.081 13.0 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding BLOC1_2 PF10046.4 ESA20623.1 - 0.0069 16.5 0.3 0.015 15.4 0.2 1.6 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Streptin-Immun PF11083.3 ESA20623.1 - 0.0072 16.2 0.3 0.2 11.6 0.1 2.2 1 1 1 2 2 2 1 Lantibiotic streptin immunity protein MtrG PF04210.8 ESA20623.1 - 0.011 15.3 0.8 0.091 12.4 0.1 2.5 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2461 PF09365.5 ESA20623.1 - 0.036 13.4 0.2 0.051 12.9 0.2 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) SF-assemblin PF06705.6 ESA20623.1 - 0.051 12.7 0.1 0.062 12.4 0.1 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin Lectin_N PF03954.9 ESA20623.1 - 0.058 12.8 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain HalX PF08663.5 ESA20623.1 - 0.058 13.3 2.1 0.24 11.3 0.2 2.2 1 1 1 2 2 2 0 HalX domain DUF1664 PF07889.7 ESA20623.1 - 0.062 13.0 0.4 0.08 12.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.8 ESA20623.1 - 0.076 11.4 0.1 0.08 11.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF4164 PF13747.1 ESA20623.1 - 0.13 12.3 0.3 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) p450 PF00067.17 ESA20625.1 - 8.2e-38 130.1 0.0 9e-38 129.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA20625.1 - 0.037 14.0 0.0 0.066 13.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1811) PRTase_3 PF15610.1 ESA20625.1 - 0.071 12.0 0.0 0.097 11.5 0.0 1.1 1 0 0 1 1 1 0 PRTase ComF-like RicinB_lectin_2 PF14200.1 ESA20626.1 - 0.0012 19.1 1.8 0.46 10.8 0.0 2.8 2 2 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Tissue_fac PF01108.12 ESA20626.1 - 0.14 11.8 2.2 0.71 9.6 1.5 2.1 1 1 0 1 1 1 0 Tissue factor Tissue_fac PF01108.12 ESA20627.1 - 0.057 13.1 1.6 0.42 10.3 1.1 2.3 1 1 0 1 1 1 0 Tissue factor RicinB_lectin_2 PF14200.1 ESA20627.1 - 0.21 11.9 1.6 11 6.4 0.0 2.5 2 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like p450 PF00067.17 ESA20628.1 - 1.3e-49 168.9 0.0 1.6e-49 168.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1811 PF08838.5 ESA20628.1 - 0.0017 18.2 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1811) Enolase_C PF00113.17 ESA20631.1 - 0.045 12.7 1.5 0.21 10.5 0.1 2.1 1 1 0 2 2 2 0 Enolase, C-terminal TIM barrel domain p450 PF00067.17 ESA20632.1 - 1.9e-73 247.5 0.3 2.4e-73 247.2 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 PP2C PF00481.16 ESA20633.1 - 5.8e-40 137.2 0.0 1.3e-39 136.1 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESA20633.1 - 0.0037 16.6 0.0 0.0091 15.4 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C DUF2713 PF10897.3 ESA20634.1 - 0.0025 17.1 0.0 0.0038 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2713) SET PF00856.23 ESA20634.1 - 0.046 14.0 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 SET domain PP-binding PF00550.20 ESA20635.1 - 3.3e-11 43.2 1.0 4.6e-11 42.8 0.7 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 ESA20635.1 - 1.4e-06 28.2 1.8 1.9e-06 27.8 1.3 1.2 1 0 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 ESA20635.1 - 0.051 13.6 0.7 0.089 12.8 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Phosducin PF02114.11 ESA20636.1 - 8.1e-30 103.4 4.3 9.9e-30 103.1 3.0 1.1 1 0 0 1 1 1 1 Phosducin PM0188 PF11477.3 ESA20636.1 - 0.011 14.6 1.3 0.016 14.0 0.9 1.2 1 0 0 1 1 1 0 Sialyltransferase PMO188 TT_ORF1 PF02956.9 ESA20636.1 - 0.1 11.0 0.3 0.11 10.8 0.2 1.1 1 0 0 1 1 1 0 TT viral orf 1 Sld5 PF05916.6 ESA20636.1 - 0.44 10.8 3.5 0.9 9.8 1.4 2.2 2 1 0 2 2 2 0 GINS complex protein 4HB_MCP_1 PF12729.2 ESA20636.1 - 1.7 7.9 11.0 0.072 12.4 3.1 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Slu7 PF11708.3 ESA20637.1 - 1.6e-80 270.2 24.1 2.8e-80 269.5 16.7 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 ESA20637.1 - 0.12 12.0 3.7 0.061 13.0 0.7 1.9 2 0 0 2 2 2 0 Zinc knuckle RRM_1 PF00076.17 ESA20638.1 - 3.5e-20 71.3 0.0 6.2e-11 41.7 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA20638.1 - 2.2e-17 62.7 0.0 6.6e-12 45.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA20638.1 - 0.00027 20.6 0.0 0.00099 18.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN PF06003.7 ESA20639.1 - 0.4 9.7 12.7 0.13 11.3 6.6 1.7 1 1 1 2 2 2 0 Survival motor neuron protein (SMN) PRP1_N PF06424.7 ESA20639.1 - 6.4 7.1 11.7 12 6.1 7.2 2.1 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal G-patch PF01585.18 ESA20640.1 - 4e-17 61.7 0.8 8.3e-17 60.7 0.6 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 ESA20640.1 - 5.9e-10 38.8 0.1 5.9e-10 38.8 0.1 2.4 3 0 0 3 3 3 1 DExH-box splicing factor binding site zf-C2H2_jaz PF12171.3 ESA20640.1 - 0.096 12.8 0.6 0.19 11.9 0.4 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Choline_kinase PF01633.15 ESA20641.1 - 1.5e-64 217.4 0.2 1.5e-64 217.4 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.18 ESA20641.1 - 1.2e-10 41.5 0.0 2.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family adh_short PF00106.20 ESA20642.1 - 6e-29 101.0 0.0 5e-28 98.0 0.1 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA20642.1 - 7.2e-26 91.4 0.0 8.7e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA20642.1 - 1.4e-08 34.6 0.1 2.6e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 ESA20642.1 - 0.0029 17.2 0.3 0.006 16.2 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 ESA20642.1 - 0.012 15.0 0.4 0.018 14.4 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_26 PF13659.1 ESA20642.1 - 0.047 13.7 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_7 PF13241.1 ESA20642.1 - 0.084 13.1 0.5 0.18 12.0 0.3 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding WD40 PF00400.27 ESA20643.1 - 3.1e-49 163.1 23.2 2.1e-10 40.0 0.1 11.5 13 0 0 13 13 13 7 WD domain, G-beta repeat Utp12 PF04003.7 ESA20643.1 - 6.2e-18 64.7 0.4 1.1e-17 63.9 0.3 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family RAB3GAP2_N PF14655.1 ESA20643.1 - 1.7e-05 24.0 0.1 0.0017 17.4 0.0 2.9 3 1 1 4 4 4 1 Rab3 GTPase-activating protein regulatory subunit N-terminus UTP15_C PF09384.5 ESA20643.1 - 0.038 13.6 0.1 0.065 12.9 0.1 1.3 1 0 0 1 1 1 0 UTP15 C terminal MraZ PF02381.13 ESA20643.1 - 0.047 13.4 0.6 3 7.6 0.1 3.2 3 0 0 3 3 3 0 MraZ protein IlvC PF01450.14 ESA20644.1 - 3.7e-44 150.1 0.0 5.6e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.7 ESA20644.1 - 1.4e-35 122.0 0.2 2.3e-24 85.6 0.0 2.4 1 1 1 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain Pkinase_Tyr PF07714.12 ESA20645.1 - 2.6e-38 131.6 0.0 4.4e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20645.1 - 1.4e-30 106.3 0.3 2.8e-30 105.3 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA20645.1 - 0.0059 15.9 0.1 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 RIO1 family BTB PF00651.26 ESA20647.1 - 3.3e-11 43.1 0.2 7.7e-11 41.9 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20647.1 - 8.7e-10 38.7 0.6 4.1e-09 36.5 0.3 2.3 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA20647.1 - 0.00026 20.7 0.4 0.0026 17.5 0.0 2.6 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA20648.1 - 1.7e-16 60.1 0.1 4e-16 58.9 0.0 1.7 1 1 1 2 2 2 1 BTB/POZ domain GDA1_CD39 PF01150.12 ESA20648.1 - 0.081 11.3 0.1 0.11 10.9 0.0 1.1 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family TLD PF07534.11 ESA20649.1 - 1.1e-16 61.0 1.9 1.1e-16 61.0 1.3 2.0 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA20649.1 - 1.2e-16 60.6 0.2 2.4e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA20650.1 - 1.3e-17 63.7 0.3 2.5e-17 62.8 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20650.1 - 9.9e-17 61.2 1.6 9.9e-17 61.2 1.1 1.9 2 0 0 2 2 2 1 TLD TEX12 PF15219.1 ESA20650.1 - 0.66 9.9 3.3 0.47 10.4 0.2 2.4 3 0 0 3 3 3 0 Testis-expressed 12 Skp1_POZ PF03931.10 ESA20650.1 - 4.4 7.4 6.4 1.5 8.9 0.4 2.9 3 0 0 3 3 3 0 Skp1 family, tetramerisation domain p450 PF00067.17 ESA20653.1 - 5.9e-48 163.5 0.1 8.4e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Pkinase_Tyr PF07714.12 ESA20654.1 - 9.6e-14 51.0 0.0 1.9e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20654.1 - 2.6e-07 30.0 0.0 5.1e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain FeoB_N PF02421.13 ESA20655.1 - 0.014 14.6 0.1 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Myb_DNA-bind_5 PF13873.1 ESA20655.1 - 0.04 13.7 1.2 0.064 13.1 0.1 1.9 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain V-SNARE PF05008.10 ESA20655.1 - 0.12 12.5 0.7 0.29 11.3 0.5 1.6 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus MIR PF02815.14 ESA20656.1 - 0.003 17.1 0.9 0.013 15.0 0.2 2.1 1 1 1 2 2 2 1 MIR domain Ins145_P3_rec PF08709.6 ESA20656.1 - 0.027 13.5 2.7 0.52 9.2 0.0 3.0 2 1 1 3 3 3 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Pkinase PF00069.20 ESA20660.1 - 0.0078 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Stc1 PF12898.2 ESA20660.1 - 0.031 14.3 0.1 0.048 13.7 0.1 1.3 1 0 0 1 1 1 0 Stc1 domain zinc-ribbons_6 PF07191.7 ESA20660.1 - 0.051 13.3 0.9 0.077 12.7 0.6 1.2 1 0 0 1 1 1 0 zinc-ribbons Plasmod_dom_1 PF09715.5 ESA20661.1 - 0.024 14.5 2.0 0.056 13.3 0.1 2.3 2 1 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) BTB PF00651.26 ESA20663.1 - 3e-16 59.3 0.8 5.2e-16 58.6 0.6 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20663.1 - 1.5e-11 44.4 1.1 3.7e-11 43.1 0.8 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20663.1 - 3.9e-07 29.8 5.2 0.00056 19.7 0.1 4.1 2 1 2 4 4 4 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA20663.1 - 0.0039 16.3 0.2 0.006 15.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) PI-PLC-X PF00388.14 ESA20663.1 - 0.055 12.8 0.2 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain FLYWCH PF04500.11 ESA20665.1 - 6.1e-12 45.2 3.5 1.2e-11 44.2 2.4 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.4 ESA20665.1 - 4e-09 36.5 0.0 1.4e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain LRR_8 PF13855.1 ESA20666.1 - 0.06 13.1 5.9 2.1 8.1 0.3 3.1 2 1 1 3 3 3 0 Leucine rich repeat DUF3281 PF11685.3 ESA20666.1 - 0.11 11.7 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3281) TLD PF07534.11 ESA20667.1 - 4.1e-15 55.9 1.7 4.7e-15 55.7 1.2 1.0 1 0 0 1 1 1 1 TLD Helicase_C PF00271.26 ESA20669.1 - 1.6e-09 37.4 0.0 2e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4511 PF14974.1 ESA20670.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4511) LAGLIDADG_3 PF14528.1 ESA20671.1 - 0.038 14.2 0.1 21 5.4 0.0 3.0 2 1 1 3 3 3 0 LAGLIDADG-like domain DUF4218 PF13960.1 ESA20672.1 - 2.7e-07 30.1 0.1 5e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DUF4479 PF14794.1 ESA20673.1 - 0.02 14.4 0.6 0.057 12.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) DUF285 PF03382.9 ESA20673.1 - 0.039 13.5 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 SopD PF11047.3 ESA20673.1 - 0.053 12.4 1.3 0.078 11.9 0.9 1.3 1 1 0 1 1 1 0 Salmonella outer protein D Arm PF00514.18 ESA20675.1 - 8.1e-95 307.8 17.3 1.4e-13 50.1 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESA20675.1 - 2.1e-26 92.0 1.4 2e-08 34.4 0.0 5.5 1 1 5 6 6 6 6 HEAT repeats IBB PF01749.15 ESA20675.1 - 3.5e-22 78.3 3.3 5.9e-22 77.6 2.3 1.4 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.1 ESA20675.1 - 9.7e-20 70.4 6.5 5.8e-07 29.8 0.1 6.0 4 2 1 5 5 5 3 HEAT-like repeat HEAT PF02985.17 ESA20675.1 - 3.4e-19 67.1 0.3 0.00015 21.5 0.0 7.3 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.8 ESA20675.1 - 7.9e-11 41.5 0.1 0.011 14.8 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.15 ESA20675.1 - 1.7e-07 29.9 0.0 2.5e-06 26.1 0.0 2.5 1 1 2 3 3 3 1 Adaptin N terminal region V-ATPase_H_C PF11698.3 ESA20675.1 - 1e-05 25.4 0.0 0.27 11.1 0.0 4.4 4 1 1 5 5 5 2 V-ATPase subunit H RICTOR_V PF14668.1 ESA20675.1 - 0.0046 16.8 6.1 1.1 9.2 0.0 4.5 3 2 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 Proteasom_PSMB PF10508.4 ESA20675.1 - 0.036 12.3 0.2 0.78 7.9 0.0 2.7 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit HEAT_PBS PF03130.11 ESA20675.1 - 0.05 14.0 4.5 10 6.9 0.0 4.9 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Mo25 PF08569.6 ESA20675.1 - 0.09 11.7 0.1 0.22 10.5 0.0 1.7 2 0 0 2 2 2 0 Mo25-like DJ-1_PfpI PF01965.19 ESA20676.1 - 1e-32 112.6 0.1 1.4e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 ESA20676.1 - 1.1e-17 63.7 0.0 1.4e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Putative amidotransferase GATase_3 PF07685.9 ESA20676.1 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain VWA_2 PF13519.1 ESA20676.1 - 0.0013 18.8 0.1 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA20676.1 - 0.0032 17.2 0.6 0.051 13.2 0.2 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain SNO PF01174.14 ESA20676.1 - 0.076 12.6 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family GATase PF00117.23 ESA20676.1 - 0.11 11.9 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Pkinase PF00069.20 ESA20677.1 - 2.8e-61 206.9 0.0 3.8e-61 206.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20677.1 - 1.2e-46 158.8 0.0 1.7e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20677.1 - 1.1e-06 27.8 0.0 1.7e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA20677.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF676 PF05057.9 ESA20679.1 - 6e-32 110.7 0.2 1e-31 109.9 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.20 ESA20679.1 - 0.0045 16.6 0.0 0.0084 15.7 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) LCAT PF02450.10 ESA20679.1 - 0.09 11.7 0.1 0.16 10.9 0.1 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.2 ESA20679.1 - 0.15 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.20 ESA20680.1 - 1.4e-54 184.9 0.1 1.6e-54 184.7 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20680.1 - 5.2e-25 87.9 0.0 6.9e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA20680.1 - 0.0011 18.0 0.0 0.0085 15.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA20680.1 - 0.0018 17.6 1.0 0.0082 15.5 0.1 2.1 1 1 1 2 2 2 1 RIO1 family L_protein_N PF15518.1 ESA20680.1 - 0.026 13.9 0.7 0.22 10.9 0.1 2.2 2 0 0 2 2 2 0 L protein N-terminus APH PF01636.18 ESA20680.1 - 0.029 14.1 0.0 0.28 10.8 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pescadillo_N PF06732.6 ESA20681.1 - 1.6e-125 418.0 3.1 1.6e-125 418.0 2.1 2.4 2 1 1 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 ESA20681.1 - 3.6e-13 49.4 0.0 1.2e-12 47.7 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIM_bind PF01803.11 ESA20682.1 - 6.2e-41 140.0 6.0 4.7e-35 120.8 0.4 2.5 2 1 1 3 3 3 2 LIM-domain binding protein TFIIA PF03153.8 ESA20682.1 - 2.4 7.9 7.8 3.4 7.4 5.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WHIM1 PF15612.1 ESA20683.1 - 0.012 15.4 0.0 0.057 13.3 0.0 2.2 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 WHIM2 PF15613.1 ESA20683.1 - 0.067 13.1 0.2 0.22 11.5 0.2 1.9 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 DUF2968 PF11180.3 ESA20683.1 - 0.74 9.1 5.4 1.5 8.2 3.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) DUF4407 PF14362.1 ESA20683.1 - 1.3 7.9 6.4 3.8 6.3 0.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Ins145_P3_rec PF08709.6 ESA20685.1 - 0.0059 15.6 0.0 0.012 14.6 0.0 1.5 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA20685.1 - 0.036 13.6 0.1 0.13 11.7 0.1 2.1 1 1 0 1 1 1 0 MIR domain YolD PF08863.5 ESA20685.1 - 7.5 6.4 9.0 4.5 7.1 0.7 3.3 4 0 0 4 4 4 0 YolD-like protein Ins145_P3_rec PF08709.6 ESA20686.1 - 0.0032 16.5 0.1 0.01 14.8 0.0 1.8 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor DUF573 PF04504.9 ESA20686.1 - 0.015 15.5 2.4 0.027 14.7 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF573 MIR PF02815.14 ESA20687.1 - 0.00049 19.6 3.8 0.14 11.7 0.3 3.9 3 2 1 4 4 4 3 MIR domain LpxD PF04613.9 ESA20687.1 - 0.08 12.4 0.1 14 5.2 0.0 2.7 3 0 0 3 3 3 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Ins_allergen_rp PF06757.8 ESA20689.1 - 0.073 12.5 0.1 0.079 12.4 0.0 1.1 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification Cortexin PF11057.3 ESA20691.1 - 0.13 11.8 0.3 0.13 11.8 0.2 2.8 3 1 0 3 3 3 0 Cortexin of kidney Peptidase_C48 PF02902.14 ESA20692.1 - 8.3e-26 90.9 1.6 1.3e-25 90.3 1.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF357 PF04010.8 ESA20692.1 - 0.082 12.6 0.2 0.21 11.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF357) DUF2972 PF11186.3 ESA20693.1 - 0.002 18.0 3.9 0.0033 17.3 1.9 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2972) DUF4511 PF14974.1 ESA20693.1 - 0.064 13.0 0.1 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4511) DUF2951 PF11166.3 ESA20693.1 - 0.14 12.0 2.1 4.7 7.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) adh_short PF00106.20 ESA20694.1 - 1.7e-15 57.3 0.0 1.9e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20694.1 - 2.1e-09 37.2 0.0 2.7e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA20694.1 - 0.0038 16.1 0.0 0.0045 15.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short_C2 PF13561.1 ESA20694.1 - 0.0043 16.8 0.0 0.0053 16.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Toxin_64 PF15542.1 ESA20694.1 - 0.12 13.0 0.9 0.21 12.2 0.6 1.5 1 1 0 1 1 1 0 Putative toxin 64 SCO1-SenC PF02630.9 ESA20695.1 - 2.5e-57 193.2 0.6 3e-57 193.0 0.4 1.0 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 ESA20695.1 - 0.00012 21.7 0.0 0.00025 20.7 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 ESA20695.1 - 0.0014 18.6 0.1 0.0034 17.4 0.0 1.8 2 1 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.5 ESA20695.1 - 0.04 13.4 0.0 0.098 12.2 0.0 1.7 1 1 0 1 1 1 0 Redoxin PcrB PF01884.12 ESA20695.1 - 0.079 12.1 0.0 0.16 11.1 0.0 1.5 1 1 0 1 1 1 0 PcrB family Alk_phosphatase PF00245.15 ESA20696.1 - 2.7e-101 339.3 0.0 3.1e-101 339.1 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase EFG_C PF00679.19 ESA20696.1 - 0.045 13.6 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 Elongation factor G C-terminus SET PF00856.23 ESA20697.1 - 1.2e-23 84.2 2.4 4.6e-23 82.3 1.7 1.8 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.11 ESA20697.1 - 1.9e-05 24.8 6.1 0.00012 22.3 1.9 2.3 2 0 0 2 2 2 2 Pre-SET motif RNase_P_pop3 PF08228.6 ESA20698.1 - 3.8e-16 59.3 1.3 1.9e-11 44.0 0.0 2.6 2 1 1 3 3 3 2 RNase P subunit Pop3 IFT43 PF15305.1 ESA20699.1 - 0.076 13.0 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Intraflagellar transport protein 43 PAS_7 PF12860.2 ESA20699.1 - 0.26 11.3 2.8 0.43 10.6 1.9 1.3 1 0 0 1 1 1 0 PAS fold DDE_1 PF03184.14 ESA20701.1 - 8.7e-33 113.2 0.1 1.4e-32 112.5 0.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA20701.1 - 3.5e-12 45.9 0.1 8.3e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Tetraspannin PF00335.15 ESA20701.1 - 0.096 11.9 0.2 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Tetraspanin family Myb_DNA-binding PF00249.26 ESA20703.1 - 0.00015 21.7 0.1 0.00047 20.1 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA20703.1 - 0.00036 20.5 0.7 0.0011 18.9 0.5 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain adh_short PF00106.20 ESA20704.1 - 5.5e-17 62.1 0.0 8.2e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20704.1 - 1.1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Toxin_64 PF15542.1 ESA20704.1 - 0.039 14.5 0.1 0.36 11.4 0.0 2.6 1 1 1 2 2 2 0 Putative toxin 64 MSA-2c PF12238.3 ESA20704.1 - 0.2 11.2 1.1 16 5.1 0.1 2.4 2 0 0 2 2 2 0 Merozoite surface antigen 2c DUF4611 PF15387.1 ESA20705.1 - 0.0033 17.5 6.3 0.004 17.2 4.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) Myc_N PF01056.13 ESA20705.1 - 0.58 9.2 5.3 0.54 9.3 3.7 1.0 1 0 0 1 1 1 0 Myc amino-terminal region BSP_II PF05432.6 ESA20705.1 - 0.59 9.3 7.4 0.57 9.4 5.1 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nucleoplasmin PF03066.10 ESA20705.1 - 2 7.9 7.2 1.9 7.9 5.0 1.1 1 0 0 1 1 1 0 Nucleoplasmin FAM176 PF14851.1 ESA20705.1 - 2 8.0 7.2 2.1 8.0 5.0 1.1 1 0 0 1 1 1 0 FAM176 family DDE_1 PF03184.14 ESA20706.1 - 3.5e-28 98.2 0.0 4e-28 98.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA20706.1 - 0.034 13.9 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF4208 PF13907.1 ESA20707.1 - 0.0072 16.5 2.5 0.83 9.9 0.2 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4208) Rubis-subs-bind PF09273.6 ESA20707.1 - 0.027 14.4 0.2 0.66 9.8 0.0 2.3 1 1 1 2 2 2 0 Rubisco LSMT substrate-binding Methyltransf_11 PF08241.7 ESA20708.1 - 8.8e-13 48.5 0.0 1.5e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA20708.1 - 4.2e-12 46.0 0.0 6.5e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA20708.1 - 3.2e-10 40.2 0.0 6.7e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA20708.1 - 2.8e-09 36.7 0.0 1.5e-08 34.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA20708.1 - 9.5e-08 31.4 0.0 1.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA20708.1 - 1.2e-07 32.3 0.0 6.7e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA20708.1 - 5.5e-07 29.9 0.0 9.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA20708.1 - 1.2e-05 24.4 0.0 0.00011 21.3 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 ESA20708.1 - 0.00036 20.5 0.0 0.00067 19.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA20708.1 - 0.00036 20.5 0.0 0.0006 19.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.9 ESA20708.1 - 0.0096 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 ESA20708.1 - 0.065 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.13 ESA20708.1 - 0.078 12.1 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase F-box-like PF12937.2 ESA20709.1 - 0.0064 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like Zn_clus PF00172.13 ESA20710.1 - 0.00082 19.2 16.8 0.0021 17.9 11.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase_Tyr PF07714.12 ESA20711.1 - 2.8e-07 29.8 0.0 4.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TBPIP PF07106.8 ESA20712.1 - 0.0065 16.0 3.8 0.0092 15.5 2.6 1.2 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4473 PF14747.1 ESA20712.1 - 0.1 12.7 0.2 0.31 11.2 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4473) DUF4613 PF15390.1 ESA20712.1 - 0.11 10.6 1.6 0.12 10.4 1.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF2935 PF11155.3 ESA20712.1 - 0.44 10.6 4.0 0.7 9.9 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Dimer_Tnp_hAT PF05699.9 ESA20714.1 - 9.7e-19 66.7 0.1 2.2e-18 65.6 0.1 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA20714.1 - 0.0015 18.4 0.4 0.038 13.9 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4413) Ribosomal_S10 PF00338.17 ESA20714.1 - 0.019 14.8 0.4 0.045 13.6 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e EZH2_WD-Binding PF11616.3 ESA20714.1 - 0.98 9.3 0.1 0.98 9.3 0.0 2.8 3 0 0 3 3 3 0 WD repeat binding protein EZH2 SWIM PF04434.12 ESA20716.1 - 0.0019 17.5 0.1 0.0043 16.4 0.0 1.5 1 0 0 1 1 1 1 SWIM zinc finger DUF2469 PF10611.4 ESA20716.1 - 2.3 8.6 5.0 4 7.8 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2469) SCRL PF06876.7 ESA20718.1 - 0.07 13.1 1.2 0.13 12.1 0.8 1.4 1 1 0 1 1 1 0 Plant self-incompatibility response (SCRL) protein DUF4528 PF15031.1 ESA20719.1 - 0.012 15.3 0.1 0.012 15.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) adh_short PF00106.20 ESA20720.1 - 6.2e-19 68.5 0.0 7.9e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20720.1 - 1.4e-09 37.8 0.0 1.8e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 ESA20720.1 - 0.0034 16.3 0.0 0.0046 15.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short_C2 PF13561.1 ESA20720.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DUF1961 PF09224.6 ESA20720.1 - 0.069 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1961) TMEM61 PF15105.1 ESA20721.1 - 1.3 8.4 3.9 1.4 8.3 2.7 1.1 1 0 0 1 1 1 0 TMEM61 protein family gpUL132 PF11359.3 ESA20727.1 - 0.29 10.4 1.7 0.4 9.9 1.2 1.1 1 0 0 1 1 1 0 Glycoprotein UL132 Haemadin PF09065.5 ESA20727.1 - 0.91 9.1 3.0 1.8 8.2 2.1 1.5 1 0 0 1 1 1 0 Haemadin CDC45 PF02724.9 ESA20729.1 - 0.78 7.7 6.5 1 7.3 4.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.7 ESA20729.1 - 2.2 7.9 7.0 2.9 7.5 4.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.7 ESA20729.1 - 2.5 7.3 5.6 3.2 6.9 3.9 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 ESA20729.1 - 9.1 4.0 8.0 12 3.6 5.6 1.0 1 0 0 1 1 1 0 Nop14-like family Kelch_4 PF13418.1 ESA20730.1 - 1.3e-08 34.5 0.4 0.0054 16.4 0.0 4.1 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA20730.1 - 5e-05 22.9 0.1 0.16 11.8 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.1 ESA20730.1 - 0.00012 21.8 0.9 0.17 11.8 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA20730.1 - 0.00023 21.2 3.3 0.064 13.4 0.0 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA20730.1 - 0.0049 16.9 1.5 4.5 7.6 0.0 3.9 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESA20730.1 - 0.08 12.5 13.6 2.1 7.9 0.2 4.4 5 0 0 5 5 5 0 Kelch motif Kelch_4 PF13418.1 ESA20731.1 - 1.5e-08 34.2 4.0 7.6e-06 25.6 0.0 4.1 3 1 1 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA20731.1 - 0.00052 20.1 0.8 0.55 10.4 0.1 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA20731.1 - 0.0023 17.8 3.8 0.0093 15.9 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.10 ESA20731.1 - 0.0024 17.5 3.3 2.6 7.9 0.0 4.5 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.1 ESA20731.1 - 0.25 11.5 5.2 0.34 11.1 0.0 3.5 4 0 0 4 4 4 0 Kelch motif HMG_box PF00505.14 ESA20732.1 - 6.5e-17 61.5 1.6 6.9e-17 61.4 1.1 1.0 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA20732.1 - 1e-05 25.8 0.1 1.2e-05 25.5 0.1 1.0 1 0 0 1 1 1 1 HMG-box domain P63C PF10546.4 ESA20732.1 - 0.013 15.4 0.2 0.015 15.2 0.1 1.1 1 0 0 1 1 1 0 P63C domain NUDIX_2 PF13869.1 ESA20732.1 - 0.028 13.7 0.5 0.031 13.6 0.4 1.1 1 0 0 1 1 1 0 Nucleotide hydrolase HMG_box_5 PF14887.1 ESA20732.1 - 0.059 13.1 0.3 0.064 13.0 0.2 1.1 1 0 0 1 1 1 0 HMG (high mobility group) box 5 NEMO PF11577.3 ESA20733.1 - 0.0028 17.3 0.4 0.081 12.6 0.0 2.8 2 0 0 2 2 2 1 NF-kappa-B essential modulator NEMO DUF4239 PF14023.1 ESA20733.1 - 1.1 8.6 3.9 4.6 6.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF445 PF04286.7 ESA20733.1 - 9.5 5.6 19.0 6e+02 -0.3 13.1 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Thiolase_N PF00108.18 ESA20734.1 - 1.8e-98 328.7 0.6 1.9e-98 328.6 0.4 1.0 1 0 0 1 1 1 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 ESA20734.1 - 7.1e-06 25.6 0.9 0.00015 21.3 0.4 2.3 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.6 ESA20734.1 - 0.042 12.2 0.1 0.06 11.7 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Methyltransf_11 PF08241.7 ESA20735.1 - 5.2e-12 46.0 0.0 1.5e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA20735.1 - 2.3e-11 43.5 0.2 4.1e-10 39.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA20735.1 - 1.5e-09 37.7 0.0 2.1e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA20735.1 - 8.6e-07 29.2 0.0 2.5e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA20735.1 - 7.4e-06 25.2 0.0 4.5e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 ESA20735.1 - 1.8e-05 25.2 0.0 0.00016 22.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA20735.1 - 1.8e-05 23.8 0.0 4.3e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.7 ESA20735.1 - 2.6e-05 24.6 0.0 0.00029 21.2 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 ESA20735.1 - 0.0008 17.8 0.0 0.014 13.7 0.0 2.0 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 ESA20735.1 - 0.0047 16.3 0.0 0.0087 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.10 ESA20735.1 - 0.0085 15.7 0.0 0.03 13.9 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase PrmA PF06325.8 ESA20735.1 - 0.015 14.4 0.0 0.029 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 ESA20735.1 - 0.023 14.2 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 ESA20735.1 - 0.03 13.4 0.2 0.072 12.1 0.0 1.7 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase MetW PF07021.7 ESA20735.1 - 0.033 13.5 0.0 0.66 9.3 0.0 2.2 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW NOGCT PF08155.6 ESA20735.1 - 0.036 13.7 0.0 3.6 7.3 0.0 2.7 2 0 0 2 2 2 0 NOGCT (NUC087) domain DUF3942 PF13078.1 ESA20735.1 - 0.094 12.8 0.6 0.21 11.7 0.1 1.9 2 1 0 2 2 1 0 Protein of unknown function (DUF3942) Methyltransf_26 PF13659.1 ESA20735.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain BTB PF00651.26 ESA20736.1 - 1.1e-19 70.4 0.1 2.4e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20736.1 - 5.2e-10 39.4 1.0 1.2e-09 38.2 0.7 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20736.1 - 6.9e-06 25.8 0.3 0.00051 19.8 0.0 2.9 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF2414 PF10309.4 ESA20736.1 - 0.075 12.7 0.4 0.36 10.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2414) RNase_E_G PF10150.4 ESA20737.1 - 0.00084 18.6 0.1 0.0035 16.6 0.0 2.0 1 1 1 2 2 2 1 Ribonuclease E/G family p450 PF00067.17 ESA20738.1 - 6.7e-40 136.9 0.0 7.4e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Beach PF02138.13 ESA20739.1 - 1.2e-115 385.5 1.8 3.1e-115 384.2 1.2 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 ESA20739.1 - 3.6e-28 97.5 0.5 2.2e-27 94.9 0.4 2.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 ESA20739.1 - 1.2e-07 31.3 11.0 3.2e-06 26.7 0.4 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.1 ESA20739.1 - 5.2e-07 30.0 0.0 1.4e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1088 PF06469.6 ESA20739.1 - 0.0014 18.0 7.2 0.0034 16.8 5.0 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) tRNA-synt_2b PF00587.20 ESA20740.1 - 5.3e-40 136.8 0.0 1.1e-39 135.8 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Jnk-SapK_ap_N PF09744.4 ESA20740.1 - 0.0013 18.7 1.6 0.002 18.1 1.1 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 GbpC PF08363.5 ESA20740.1 - 0.016 14.4 1.0 0.023 13.9 0.7 1.2 1 0 0 1 1 1 0 Glucan-binding protein C RGS PF00615.14 ESA20741.1 - 0.072 13.1 0.6 0.18 11.8 0.2 1.8 1 1 0 1 1 1 0 Regulator of G protein signaling domain ADH_zinc_N PF00107.21 ESA20742.1 - 2e-20 72.6 0.0 3.4e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 ESA20742.1 - 4e-06 27.7 0.0 1e-05 26.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.1 ESA20742.1 - 0.0014 18.6 0.3 0.003 17.5 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding Sel1 PF08238.7 ESA20744.1 - 9.9e-71 232.6 17.1 9.6e-12 45.1 0.0 6.0 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA20744.1 - 2.1e-07 30.9 3.8 0.24 11.9 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat MIT PF04212.13 ESA20744.1 - 1.3e-06 28.1 8.3 0.19 11.6 0.1 4.9 4 2 1 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA20744.1 - 1.8e-05 24.5 7.1 1.3 9.4 0.0 6.0 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA20744.1 - 5.7e-05 23.3 3.6 0.7 10.2 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA20744.1 - 0.00041 20.1 0.0 0.12 12.0 0.0 3.5 1 1 1 2 2 2 1 Caspase domain DUF3087 PF11286.3 ESA20744.1 - 0.00055 19.2 1.8 1 8.5 0.0 3.4 2 1 2 4 4 4 2 Protein of unknown function (DUF3087) TPR_20 PF14561.1 ESA20744.1 - 0.0009 19.3 0.3 0.89 9.7 0.0 3.7 1 1 4 5 5 5 1 Tetratricopeptide repeat HTH_16 PF12645.2 ESA20744.1 - 0.0009 19.1 2.3 2.7 7.9 0.0 3.8 4 0 0 4 4 4 1 Helix-turn-helix domain TPR_16 PF13432.1 ESA20744.1 - 0.00092 19.8 0.1 1.5 9.6 0.1 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA20744.1 - 0.0011 18.8 11.9 6.1 6.8 0.3 5.4 1 1 4 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA20744.1 - 0.0013 18.3 21.8 0.82 9.3 3.1 4.5 1 1 1 3 3 3 2 TPR repeat Apc3 PF12895.2 ESA20744.1 - 0.014 15.4 12.2 0.025 14.7 0.6 4.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.15 ESA20744.1 - 0.023 14.6 2.7 41 4.4 0.0 4.8 5 0 0 5 5 5 0 PPR repeat Ank_2 PF12796.2 ESA20744.1 - 0.054 13.8 1.6 0.13 12.6 0.4 2.1 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) DUF1691 PF07950.6 ESA20744.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1691) Prenyltrans_1 PF13243.1 ESA20744.1 - 0.15 12.0 3.4 20 5.2 0.5 4.0 1 1 2 3 3 3 0 Prenyltransferase-like zf-GRF PF06839.7 ESA20744.1 - 0.71 9.8 5.0 3.6 7.5 0.0 3.9 4 0 0 4 4 4 0 GRF zinc finger TPR_2 PF07719.12 ESA20744.1 - 1.2 9.2 33.0 1.7 8.7 0.1 8.6 11 0 0 11 11 11 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA20744.1 - 1.8 8.2 30.8 0.9 9.2 0.1 8.2 10 0 0 10 10 10 0 Tetratricopeptide repeat MSP7_C PF12948.2 ESA20745.1 - 0.014 15.6 1.9 0.018 15.2 1.3 1.2 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain V-ATPase_C PF03223.10 ESA20745.1 - 0.021 13.7 0.7 0.025 13.5 0.5 1.1 1 0 0 1 1 1 0 V-ATPase subunit C DUF3829 PF12889.2 ESA20745.1 - 0.021 14.0 0.4 0.025 13.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Scaffolding_pro PF11418.3 ESA20745.1 - 0.1 12.9 0.9 0.42 10.9 0.3 2.0 2 0 0 2 2 2 0 Phi29 scaffolding protein Ribosomal_L30_N PF08079.7 ESA20745.1 - 0.74 9.8 6.9 0.07 13.1 1.2 1.9 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain Sec23_helical PF04815.10 ESA20746.1 - 0.048 13.0 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Asp PF00026.18 ESA20748.1 - 1.6e-53 181.9 0.1 1.9e-53 181.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.1 ESA20748.1 - 8.2e-05 22.2 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 ESA20748.1 - 0.0064 16.9 1.9 4.1 7.9 0.1 3.4 3 1 0 3 3 3 2 Aspartyl protease TAXi_N PF14543.1 ESA20748.1 - 0.02 14.8 0.9 0.033 14.1 0.0 1.9 2 1 0 2 2 2 0 Xylanase inhibitor N-terminal Sel1 PF08238.7 ESA20749.1 - 2.4e-47 158.3 7.0 8e-10 39.0 0.7 6.1 6 0 0 6 6 6 5 Sel1 repeat MIT PF04212.13 ESA20749.1 - 3.1e-05 23.7 14.7 0.29 11.0 1.6 4.7 2 1 3 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA20749.1 - 0.00023 20.7 10.3 0.03 13.9 0.7 4.3 3 2 2 5 5 5 2 TPR repeat TPR_12 PF13424.1 ESA20749.1 - 0.046 13.6 7.7 9 6.3 0.2 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat CathepsinC_exc PF08773.6 ESA20749.1 - 0.13 12.4 1.8 0.28 11.3 0.1 2.3 2 1 1 3 3 3 0 Cathepsin C exclusion domain TPR_2 PF07719.12 ESA20749.1 - 0.82 9.7 19.2 10 6.3 0.1 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat CaM_bdg_C0 PF10562.4 ESA20749.1 - 4.4 7.2 7.5 4.5 7.2 0.5 3.4 4 0 0 4 4 4 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Glyco_transf_22 PF03901.12 ESA20750.1 - 0.0052 15.8 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HEAT_2 PF13646.1 ESA20750.1 - 0.024 14.9 0.0 0.4 10.9 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats HEAT PF02985.17 ESA20750.1 - 0.11 12.5 0.1 4 7.7 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat RPAP3_C PF13877.1 ESA20750.1 - 2.7 8.0 5.8 18 5.3 0.0 3.2 4 0 0 4 4 4 0 Potential Monad-binding region of RPAP3 NAP PF00956.13 ESA20751.1 - 2.3e-30 105.5 22.2 4.8e-30 104.4 15.4 1.5 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Ustilago_mating PF05722.7 ESA20751.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein SNARE PF05739.14 ESA20752.1 - 4.3e-11 42.3 2.5 4.3e-11 42.3 1.8 2.4 3 0 0 3 3 3 1 SNARE domain Consortin_C PF15281.1 ESA20752.1 - 0.014 14.8 0.7 1.4 8.3 0.0 3.0 3 0 0 3 3 3 0 Consortin C-terminus TBCA PF02970.11 ESA20752.1 - 0.022 14.8 0.1 0.022 14.8 0.1 3.0 2 1 1 3 3 3 0 Tubulin binding cofactor A DUF745 PF05335.8 ESA20752.1 - 0.15 11.6 3.5 1.7 8.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) PspA_IM30 PF04012.7 ESA20752.1 - 0.64 9.3 9.0 0.11 11.8 2.0 2.1 2 0 0 2 2 2 0 PspA/IM30 family DUF4200 PF13863.1 ESA20752.1 - 0.85 9.5 10.1 1.4 8.8 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Lebercilin PF15619.1 ESA20752.1 - 1.3 8.4 14.0 0.24 10.8 5.5 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Tropomyosin_1 PF12718.2 ESA20752.1 - 1.6 8.5 14.6 3.5 7.4 4.5 2.5 2 0 0 2 2 2 0 Tropomyosin like Sigma70_r1_1 PF03979.9 ESA20755.1 - 0.07 13.0 0.1 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 Bromodomain PF00439.20 ESA20756.1 - 1.9e-13 50.1 1.6 2e-13 50.0 1.1 1.0 1 0 0 1 1 1 1 Bromodomain tRNA-Thr_ED PF08915.6 ESA20757.1 - 0.026 14.4 0.9 0.041 13.8 0.6 1.2 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase BACK PF07707.10 ESA20757.1 - 0.098 12.5 1.9 0.19 11.5 1.3 1.5 1 0 0 1 1 1 0 BTB And C-terminal Kelch EF-hand_1 PF00036.27 ESA20760.1 - 6e-24 81.4 15.7 2.3e-07 29.6 0.4 6.4 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.1 ESA20760.1 - 2.6e-20 72.3 15.3 1.2e-09 38.1 0.7 4.4 2 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 ESA20760.1 - 8.9e-20 68.7 8.7 1.5e-05 24.4 0.2 6.0 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.1 ESA20760.1 - 1e-17 63.4 11.4 1.6e-07 30.8 0.1 4.7 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA20760.1 - 3.1e-16 57.8 12.0 2e-05 23.7 0.1 4.9 5 0 0 5 5 5 4 EF hand EF-hand_4 PF12763.2 ESA20760.1 - 3.1e-09 36.5 3.3 0.021 14.5 0.2 4.3 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA20760.1 - 5.5e-06 26.3 1.7 0.0087 16.0 0.1 2.9 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 ESA20760.1 - 0.056 13.1 13.5 0.79 9.4 0.0 4.6 4 1 1 5 5 5 0 EF hand Haemagg_act PF05860.8 ESA20760.1 - 0.1 12.3 0.0 3.3 7.4 0.0 2.4 2 1 0 2 2 2 0 haemagglutination activity domain Swi5 PF07061.6 ESA20760.1 - 0.2 11.4 7.7 2.4 7.9 0.1 3.7 3 1 0 3 3 3 0 Swi5 Exo_endo_phos PF03372.18 ESA20763.1 - 3.6e-06 27.1 0.1 5.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA20763.1 - 0.036 13.6 0.6 0.13 11.8 0.0 2.2 3 0 0 3 3 3 0 Endonuclease-reverse transcriptase Mem_trans PF03547.13 ESA20763.1 - 0.16 10.2 0.3 0.16 10.2 0.2 1.2 1 0 0 1 1 1 0 Membrane transport protein TFIIF_alpha PF05793.7 ESA20763.1 - 1.9 6.7 29.7 3 6.1 20.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pkinase_Tyr PF07714.12 ESA20765.1 - 1.1e-09 37.8 0.0 1.5e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20765.1 - 0.00015 21.0 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CBFB_NFYA PF02045.10 ESA20766.1 - 4.1e-23 81.6 6.7 7.3e-23 80.8 4.6 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B CENP-B_dimeris PF09026.5 ESA20766.1 - 0.08 13.1 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Peptidase_M10 PF00413.19 ESA20767.1 - 0.00012 21.8 0.0 0.053 13.2 0.0 2.7 2 0 0 2 2 2 2 Matrixin DUF3267 PF11667.3 ESA20767.1 - 0.021 15.0 1.9 1.7 8.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3267) SprT-like PF10263.4 ESA20767.1 - 0.14 11.7 0.0 18 4.9 0.0 2.4 2 0 0 2 2 2 0 SprT-like family Peptidase_M8 PF01457.11 ESA20767.1 - 0.23 9.7 0.0 2.5 6.3 0.0 2.0 2 0 0 2 2 2 0 Leishmanolysin DBD_Tnp_Mut PF03108.10 ESA20769.1 - 0.011 15.2 0.2 0.062 12.8 0.0 2.2 3 0 0 3 3 3 0 MuDR family transposase BTB PF00651.26 ESA20770.1 - 2.4e-18 66.1 0.2 3.8e-18 65.4 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain PALP PF00291.20 ESA20770.1 - 0.14 11.3 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme FAR1 PF03101.10 ESA20771.1 - 5.1e-07 30.1 4.8 5.1e-07 30.1 3.3 2.2 2 0 0 2 2 2 1 FAR1 DNA-binding domain NRN1 PF15056.1 ESA20771.1 - 0.0049 16.7 0.5 0.024 14.5 0.1 2.3 2 0 0 2 2 2 1 Neuritin protein family DBD_Tnp_Mut PF03108.10 ESA20771.1 - 0.074 12.6 1.4 0.26 10.8 0.1 2.6 2 0 0 2 2 2 0 MuDR family transposase SWIM PF04434.12 ESA20771.1 - 2 7.9 5.8 0.32 10.5 1.3 1.8 2 0 0 2 2 2 0 SWIM zinc finger Spore_II_R PF09551.5 ESA20772.1 - 0.046 13.7 0.1 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) DUF3408 PF11888.3 ESA20772.1 - 0.051 13.5 4.0 0.076 12.9 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) LisH PF08513.6 ESA20772.1 - 0.075 12.8 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 LisH TFIIA PF03153.8 ESA20772.1 - 0.24 11.2 11.1 0.29 10.9 7.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.4 ESA20772.1 - 0.37 8.9 16.8 0.4 8.8 11.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 ESA20772.1 - 1.9 6.0 15.8 2.2 5.8 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4106 PF13388.1 ESA20772.1 - 6.7 5.5 13.6 7.8 5.3 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Pkinase_Tyr PF07714.12 ESA20773.1 - 2.3e-37 128.4 0.0 2.9e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20773.1 - 8.6e-34 116.8 0.0 1.3e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20774.1 - 1.5e-26 93.0 0.0 1.7e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20774.1 - 9.9e-23 80.5 0.0 1.1e-22 80.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20775.1 - 9.7e-45 152.6 0.0 1.4e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20775.1 - 4.8e-37 127.5 0.0 7.3e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-ribbon_3 PF13248.1 ESA20775.1 - 0.4 9.9 2.1 0.83 8.9 1.5 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Pkinase_Tyr PF07714.12 ESA20776.1 - 1.2e-05 24.5 0.0 1.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20776.1 - 0.00012 21.3 0.0 0.00017 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TLD PF07534.11 ESA20781.1 - 0.053 13.5 0.6 0.057 13.3 0.4 1.2 1 0 0 1 1 1 0 TLD Acyl-thio_N PF12590.3 ESA20782.1 - 0.11 12.9 2.3 0.31 11.4 1.6 1.7 1 0 0 1 1 1 0 Acyl-ATP thioesterase Pkinase_Tyr PF07714.12 ESA20783.1 - 3.3e-12 46.0 0.0 4.9e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20783.1 - 3.8e-11 42.6 0.0 5.1e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20784.1 - 2.6e-26 92.2 0.0 2.8e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20784.1 - 3.6e-24 85.2 0.0 4e-24 85.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA20785.1 - 1.7e-17 63.4 7.7 9.3e-07 29.2 0.1 4.6 5 0 0 5 5 5 2 Sel1 repeat TPR_6 PF13174.1 ESA20785.1 - 0.012 16.0 3.4 11 6.7 0.1 4.0 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA20785.1 - 0.023 15.3 1.7 0.29 11.8 0.1 2.6 2 2 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA20785.1 - 0.032 14.5 0.5 1.9 8.9 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 ESA20785.1 - 0.033 14.7 0.7 3.7 8.4 0.1 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA20785.1 - 0.059 12.9 3.1 2.3 7.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA20785.1 - 0.12 12.4 5.0 20 5.4 0.0 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat NAD_Gly3P_dh_N PF01210.18 ESA20788.1 - 3.1e-52 176.4 0.4 3.6e-52 176.2 0.3 1.0 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 ESA20788.1 - 0.00019 21.7 0.4 0.00094 19.5 0.3 2.0 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 ESA20788.1 - 0.052 13.0 0.1 0.068 12.6 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA IlvN PF07991.7 ESA20788.1 - 0.071 12.4 0.2 4.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF4496 PF14908.1 ESA20789.1 - 0.096 12.5 0.1 1 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4496) Pkinase_Tyr PF07714.12 ESA20791.1 - 1.3e-53 181.7 0.0 2.2e-53 180.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20791.1 - 4.7e-47 160.3 0.2 9.4e-47 159.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA20791.1 - 0.14 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Erythrovirus_X PF06795.6 ESA20792.1 - 0.061 13.3 2.2 0.36 10.8 0.8 2.3 2 1 0 2 2 2 0 Erythrovirus X protein COBRA1 PF06209.8 ESA20792.1 - 0.075 11.6 0.3 0.1 11.1 0.2 1.2 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) DZR PF12773.2 ESA20793.1 - 0.044 13.5 0.8 0.065 13.0 0.6 1.2 1 0 0 1 1 1 0 Double zinc ribbon DUF481 PF04338.7 ESA20793.1 - 0.053 13.2 0.1 0.066 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF481 DUF2671 PF10877.3 ESA20793.1 - 0.073 12.8 2.3 1.8 8.3 0.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2671) ATE_C PF04377.10 ESA20793.1 - 0.14 12.1 0.4 0.26 11.3 0.0 1.5 2 0 0 2 2 2 0 Arginine-tRNA-protein transferase, C terminus FAD_binding_3 PF01494.14 ESA20795.1 - 6.7e-14 51.6 0.0 1.1e-08 34.5 0.0 3.0 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 ESA20795.1 - 5.2e-05 23.1 0.0 0.00013 21.8 0.0 1.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA20795.1 - 0.00089 19.0 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 ESA20795.1 - 0.0029 17.5 0.0 0.0045 16.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 ESA20795.1 - 0.0079 16.2 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Na_H_Exchanger PF00999.16 ESA20796.1 - 1.2e-53 182.0 30.4 1.5e-53 181.7 21.0 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.1 ESA20796.1 - 0.0065 16.3 0.2 0.0065 16.3 0.2 3.1 3 0 0 3 3 3 1 YrhC-like protein Lectin_N PF03954.9 ESA20796.1 - 0.91 8.9 3.2 0.43 9.9 0.1 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Nha1_C PF08619.5 ESA20797.1 - 0.00047 19.5 8.2 0.00062 19.1 5.7 1.2 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus DUF624 PF04854.9 ESA20798.1 - 0.08 12.8 0.2 0.099 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF624 CO_dh PF02552.11 ESA20798.1 - 0.099 12.1 0.2 0.11 11.9 0.1 1.1 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Sel1 PF08238.7 ESA20799.1 - 8.4e-15 54.8 1.2 1.1e-13 51.3 0.9 2.0 2 0 0 2 2 2 1 Sel1 repeat TPR_11 PF13414.1 ESA20799.1 - 0.036 13.7 0.3 0.053 13.1 0.2 1.3 1 0 0 1 1 1 0 TPR repeat TPR_6 PF13174.1 ESA20799.1 - 0.042 14.3 0.1 0.07 13.6 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.13 ESA20799.1 - 0.068 13.0 0.3 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 ESA20799.1 - 0.25 11.0 2.8 6.6 6.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA20800.1 - 1.2e-253 814.0 123.7 1.9e-12 47.3 0.7 22.3 22 0 0 22 22 22 22 Sel1 repeat TPR_6 PF13174.1 ESA20800.1 - 4.7e-09 36.1 58.9 2.8 8.5 0.1 17.3 18 0 0 18 18 18 6 Tetratricopeptide repeat AMMECR1 PF01871.12 ESA20800.1 - 0.0052 15.9 1.1 3.6 6.6 0.0 5.0 4 3 3 7 7 7 1 AMMECR1 MgrB PF13998.1 ESA20800.1 - 0.017 14.8 3.9 1.2e+02 2.5 0.0 6.0 5 0 0 5 5 5 0 MgrB protein Ion_trans PF00520.26 ESA20801.1 - 0.0045 16.2 16.3 0.0061 15.8 11.3 1.2 1 0 0 1 1 1 1 Ion transport protein DUF4271 PF14093.1 ESA20801.1 - 0.01 15.5 3.6 0.01 15.5 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) PKD_channel PF08016.7 ESA20801.1 - 0.011 14.1 9.1 0.015 13.7 6.2 1.4 1 1 0 1 1 1 0 Polycystin cation channel L_HGMIC_fpl PF10242.4 ESA20801.1 - 0.065 13.2 1.0 0.078 12.9 0.4 1.4 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein OAD_gamma PF04277.8 ESA20801.1 - 0.24 11.7 2.2 3.7 8.0 0.2 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF1673 PF07895.6 ESA20801.1 - 3.4 7.1 11.4 4.2 6.8 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF2536 PF10750.4 ESA20802.1 - 0.12 11.9 0.3 0.18 11.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2536) DDE_3 PF13358.1 ESA20804.1 - 2.6e-07 30.4 0.1 3.9e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Myb_DNA-bind_5 PF13873.1 ESA20804.1 - 0.025 14.4 0.5 0.043 13.7 0.3 1.5 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1157 PF06636.6 ESA20805.1 - 0.12 10.9 4.3 0.18 10.3 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1157) Endonuclease_7 PF02945.10 ESA20807.1 - 0.0026 17.4 0.2 0.023 14.3 0.0 2.4 2 1 0 2 2 2 1 Recombination endonuclease VII Med9 PF07544.8 ESA20807.1 - 0.049 13.3 1.4 2.5 7.8 0.4 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HeLo PF14479.1 ESA20808.1 - 0.16 11.7 1.9 0.18 11.5 0.0 1.8 1 1 1 2 2 2 0 Prion-inhibition and propagation zf-CCHC PF00098.18 ESA20809.1 - 0.0013 18.5 5.3 0.0023 17.7 3.7 1.4 1 0 0 1 1 1 1 Zinc knuckle Asp_protease PF09668.5 ESA20809.1 - 0.058 12.9 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.1 ESA20809.1 - 0.1 12.2 1.7 0.22 11.2 1.2 1.6 1 0 0 1 1 1 0 Zinc knuckle DivIC PF04977.10 ESA20809.1 - 0.83 9.1 4.0 0.46 10.0 0.4 2.3 3 0 0 3 3 3 0 Septum formation initiator zf-CCHC_6 PF15288.1 ESA20809.1 - 5.7 6.7 12.0 4.5 7.0 6.7 2.1 2 0 0 2 2 2 0 Zinc knuckle adh_short PF00106.20 ESA20811.1 - 3.3e-17 62.8 0.0 4.8e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20811.1 - 1.6e-09 37.6 0.0 2.6e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESA20811.1 - 0.0044 16.8 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 ESA20811.1 - 0.065 12.1 0.0 0.096 11.5 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2427 PF10348.4 ESA20813.1 - 0.0032 17.0 2.1 0.0055 16.2 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) DUF4398 PF14346.1 ESA20814.1 - 0.064 13.3 0.0 0.065 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) PIF1 PF05970.9 ESA20815.1 - 6.1e-09 35.2 1.5 1.6e-05 24.0 0.0 3.1 2 1 1 3 3 3 2 PIF1-like helicase Herpes_Helicase PF02689.9 ESA20815.1 - 0.0035 15.1 0.0 0.008 13.9 0.0 1.5 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.1 ESA20815.1 - 0.036 14.1 0.0 0.083 13.0 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ORC5_C PF14630.1 ESA20817.1 - 7.6e-35 120.6 5.1 3.3e-33 115.2 3.5 2.1 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 ESA20817.1 - 4.3e-08 33.3 0.0 2.8e-06 27.4 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 ESA20817.1 - 9.9e-05 22.2 1.1 0.00028 20.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA20817.1 - 0.015 15.4 0.0 0.039 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain OATP PF03137.15 ESA20817.1 - 0.053 11.5 0.2 0.079 11.0 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Ribosomal_S10 PF00338.17 ESA20818.1 - 2e-24 85.2 0.0 3.5e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Abhydrolase_6 PF12697.2 ESA20819.1 - 1.6e-07 31.4 0.0 3.4e-07 30.3 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.8 ESA20819.1 - 5.5e-07 29.4 0.0 9.3e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.15 ESA20819.1 - 4.3e-06 26.4 0.0 7.3e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.10 ESA20819.1 - 6.1e-06 25.4 0.0 9.5e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.7 ESA20819.1 - 4.2e-05 22.9 0.0 7.6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF676 PF05057.9 ESA20819.1 - 0.007 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 ESA20819.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_8 PF06259.7 ESA20819.1 - 0.028 13.9 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase SR-25 PF10500.4 ESA20819.1 - 0.092 12.2 7.1 0.13 11.6 4.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ser_hydrolase PF06821.8 ESA20819.1 - 0.13 11.9 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase FAM178 PF14816.1 ESA20819.1 - 0.28 9.8 2.3 0.42 9.2 1.6 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 Brix PF04427.13 ESA20820.1 - 1.9e-48 164.6 0.2 2.7e-48 164.1 0.1 1.2 1 0 0 1 1 1 1 Brix domain CtaG_Cox11 PF04442.9 ESA20821.1 - 5e-62 208.1 0.2 5.8e-62 207.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 BATS PF06968.8 ESA20822.1 - 1.9e-28 98.1 0.0 5.2e-28 96.7 0.0 1.8 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 ESA20822.1 - 6.4e-14 52.4 0.1 9.5e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Nse4_C PF08743.5 ESA20823.1 - 4.5e-29 100.3 2.0 6.5e-29 99.7 0.0 2.2 2 0 0 2 2 2 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 ESA20823.1 - 8.3e-17 60.7 0.2 2e-16 59.5 0.2 1.6 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF87 PF01935.12 ESA20823.1 - 0.31 10.8 3.6 0.24 11.1 1.2 1.7 1 1 1 2 2 2 0 Domain of unknown function DUF87 DUF4523 PF15023.1 ESA20825.1 - 0.033 13.7 0.3 0.041 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) DUF262 PF03235.9 ESA20825.1 - 0.053 13.4 4.3 0.063 13.2 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF262 PRKCSH-like PF12999.2 ESA20825.1 - 0.1 12.1 1.3 0.14 11.7 0.9 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Phg_2220_C PF09524.5 ESA20825.1 - 1.9 8.5 6.9 0.98 9.4 2.7 1.9 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) Kelch_3 PF13415.1 ESA20827.1 - 6.7e-07 29.3 8.5 0.0011 19.0 0.1 5.2 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA20827.1 - 0.019 14.8 12.6 0.62 10.0 0.4 4.7 5 0 0 5 5 5 0 Kelch motif PepSY_TM_3 PF13706.1 ESA20827.1 - 0.093 12.1 2.2 0.18 11.2 1.5 1.4 1 0 0 1 1 1 0 PepSY-associated TM helix Kelch_6 PF13964.1 ESA20827.1 - 0.35 11.1 16.1 2.1 8.6 0.4 5.1 4 2 1 5 5 5 0 Kelch motif Kelch_6 PF13964.1 ESA20828.1 - 5.2e-10 39.0 15.7 0.0015 18.6 0.3 5.8 5 1 1 6 6 6 3 Kelch motif Kelch_5 PF13854.1 ESA20828.1 - 5.5e-08 32.6 11.2 0.042 13.8 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.1 ESA20828.1 - 1.3e-06 28.3 17.7 0.0086 16.2 0.1 5.4 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA20828.1 - 1.8e-06 27.6 13.1 0.0099 15.6 0.3 5.3 5 2 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA20828.1 - 6.3e-05 22.4 16.2 0.12 11.8 0.0 5.1 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.10 ESA20828.1 - 0.0028 17.3 8.0 0.22 11.3 0.0 4.0 4 1 0 4 4 4 2 Kelch motif Sel1 PF08238.7 ESA20830.1 - 7.5e-175 563.5 110.3 4.6e-13 49.3 1.0 15.8 15 1 1 16 16 16 15 Sel1 repeat MIT PF04212.13 ESA20830.1 - 4.7e-13 48.8 76.4 0.81 9.6 0.1 14.5 11 2 4 15 15 15 11 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA20830.1 - 2.7e-06 27.0 28.8 36 4.2 0.0 13.0 14 0 0 14 14 14 0 Lung surfactant protein D coiled-coil trimerisation DUF2530 PF10745.4 ESA20830.1 - 0.0028 17.6 0.1 3.1e+02 1.4 0.0 6.9 7 0 0 7 7 7 0 Protein of unknown function (DUF2530) TPR_6 PF13174.1 ESA20830.1 - 0.71 10.4 40.6 0.52 10.8 0.2 9.8 12 0 0 12 12 12 0 Tetratricopeptide repeat DUF2332 PF10094.4 ESA20830.1 - 8.5 5.2 6.9 51 2.6 0.0 3.6 3 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2332) CENP-B_dimeris PF09026.5 ESA20833.1 - 0.00041 20.5 0.1 0.00046 20.3 0.1 1.1 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF506 PF04720.7 ESA20833.1 - 0.015 14.9 0.6 0.017 14.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) FimP PF09766.4 ESA20833.1 - 0.049 12.6 2.2 0.052 12.6 1.5 1.0 1 0 0 1 1 1 0 Fms-interacting protein DUF4611 PF15387.1 ESA20833.1 - 0.05 13.7 4.5 0.069 13.3 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) BTV_NS2 PF04514.7 ESA20833.1 - 0.076 11.8 1.3 0.085 11.7 0.9 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 GET2 PF08690.5 ESA20833.1 - 0.15 11.3 1.0 0.15 11.2 0.7 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Pox_Ag35 PF03286.9 ESA20833.1 - 0.15 11.5 3.9 0.18 11.2 2.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Secretin_N_2 PF07655.8 ESA20833.1 - 8.7 6.8 9.5 12 6.4 6.6 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain Sel1 PF08238.7 ESA20835.1 - 4.9e-11 42.8 0.3 3.2e-10 40.3 0.2 1.9 2 0 0 2 2 2 1 Sel1 repeat MIT PF04212.13 ESA20835.1 - 0.13 12.2 0.2 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA20836.1 - 4e-40 135.3 15.8 1.8e-13 50.6 0.6 4.1 4 0 0 4 4 4 4 Sel1 repeat HTH_16 PF12645.2 ESA20836.1 - 0.00093 19.0 2.8 1.6 8.6 0.0 3.5 4 0 0 4 4 4 2 Helix-turn-helix domain MIT PF04212.13 ESA20836.1 - 0.0014 18.4 6.8 0.2 11.5 0.1 3.4 3 1 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_20 PF14561.1 ESA20836.1 - 0.0029 17.6 1.4 2.4 8.3 0.0 3.0 1 1 2 3 3 3 1 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA20836.1 - 0.0039 16.9 0.0 1.6 8.3 0.0 2.5 1 1 1 2 2 2 2 Caspase domain TPR_17 PF13431.1 ESA20836.1 - 0.0062 16.6 7.7 4 7.8 0.2 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA20836.1 - 0.072 12.8 1.7 9.9 5.9 0.0 3.1 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation PhageMin_Tail PF10145.4 ESA20836.1 - 0.076 12.6 2.6 0.36 10.4 1.8 2.0 1 1 0 1 1 1 0 Phage-related minor tail protein DUF3674 PF12426.3 ESA20836.1 - 0.13 11.7 2.3 4.4 6.7 0.1 2.9 3 0 0 3 3 3 0 RNA dependent RNA polymerase Sortase PF04203.8 ESA20836.1 - 0.13 11.8 0.4 0.2 11.2 0.3 1.3 1 1 0 1 1 1 0 Sortase family Flu_M1_C PF08289.6 ESA20836.1 - 0.13 12.2 0.0 48 4.0 0.0 3.0 1 1 2 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain Glyco_hydro_38 PF01074.17 ESA20836.1 - 0.15 11.2 3.0 0.18 11.0 2.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain Apc3 PF12895.2 ESA20836.1 - 0.32 11.1 9.9 0.27 11.3 3.3 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 STE PF02200.11 ESA20836.1 - 0.73 10.0 3.9 25 5.0 0.1 3.0 1 1 2 3 3 3 0 STE like transcription factor TPR_6 PF13174.1 ESA20836.1 - 0.75 10.3 5.2 18 6.0 0.2 3.3 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA20836.1 - 1.4 8.8 11.0 3 7.8 2.3 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 ESA20836.1 - 3.8 7.6 8.2 11 6.1 0.3 3.0 1 1 1 3 3 3 0 Rapamycin binding domain MRP-L46 PF11788.3 ESA20836.1 - 6.5 7.4 7.7 13 6.5 1.7 2.5 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 TPR_2 PF07719.12 ESA20836.1 - 8.5 6.5 17.8 8 6.6 0.2 5.5 6 1 1 7 7 7 0 Tetratricopeptide repeat adh_short PF00106.20 ESA20839.1 - 7e-20 71.6 0.0 9.1e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20839.1 - 1.2e-09 38.1 0.0 1.4e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 ESA20839.1 - 0.0069 16.1 0.1 0.0095 15.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 ESA20839.1 - 0.018 13.9 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2835 PF11197.3 ESA20839.1 - 0.12 12.1 0.0 0.79 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2835) Erf4 PF10256.4 ESA20840.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family POX PF07526.6 ESA20843.1 - 0.11 12.7 1.5 0.14 12.3 1.0 1.2 1 0 0 1 1 1 0 Associated with HOX HALZ PF02183.13 ESA20843.1 - 0.14 11.9 0.6 0.14 11.9 0.4 1.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper PIG-S PF10510.4 ESA20843.1 - 0.15 10.7 1.9 0.16 10.6 1.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Trypsin PF00089.21 ESA20844.1 - 0.00012 21.7 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.1 ESA20844.1 - 0.003 17.5 0.0 0.0067 16.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.8 ESA20844.1 - 0.031 13.2 1.4 0.13 11.1 0.0 2.2 2 1 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 MtrG PF04210.8 ESA20846.1 - 0.055 13.1 3.0 0.085 12.5 0.3 2.6 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2508 PF10704.4 ESA20846.1 - 0.4 10.8 5.1 1.2 9.3 0.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2508) Syntaxin-6_N PF09177.6 ESA20846.1 - 3.3 8.1 10.7 0.39 11.1 0.7 2.8 2 1 0 2 2 2 0 Syntaxin 6, N-terminal SLAP PF03217.9 ESA20847.1 - 0.19 11.9 5.0 0.52 10.5 3.4 1.7 1 1 0 1 1 1 0 Bacterial surface layer protein DUF1467 PF07330.7 ESA20849.1 - 0.099 12.4 0.0 0.11 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) F-box-like PF12937.2 ESA20850.1 - 7.3e-05 22.4 0.5 0.00025 20.6 0.3 2.0 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA20850.1 - 7.7e-05 22.3 1.0 0.024 14.4 0.1 3.2 2 0 0 2 2 2 2 Leucine rich repeat F-box PF00646.28 ESA20850.1 - 0.045 13.4 0.2 0.84 9.3 0.0 3.0 3 0 0 3 3 3 0 F-box domain adh_short PF00106.20 ESA20853.1 - 0.00055 19.9 0.0 0.00056 19.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA20853.1 - 0.012 15.3 0.0 0.013 15.1 0.0 1.0 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.10 ESA20853.1 - 0.07 12.0 0.0 0.074 11.9 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Pkinase_Tyr PF07714.12 ESA20855.1 - 0.001 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LIN37 PF15306.1 ESA20856.1 - 0.019 14.9 0.9 0.023 14.6 0.6 1.1 1 0 0 1 1 1 0 LIN37 hGDE_N PF14699.1 ESA20858.1 - 0.013 15.2 0.3 0.053 13.3 0.1 1.9 1 1 1 2 2 2 0 N-terminal domain from the human glycogen debranching enzyme F-box-like PF12937.2 ESA20860.1 - 0.0012 18.4 1.2 0.0058 16.3 0.8 2.1 1 0 0 1 1 1 1 F-box-like Trypsin PF00089.21 ESA20861.1 - 0.0061 16.1 0.1 0.029 13.9 0.1 2.0 1 1 0 1 1 1 1 Trypsin Corona_NS8 PF12093.3 ESA20861.1 - 0.024 14.9 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 Coronavirus NS8 protein Trypsin_2 PF13365.1 ESA20861.1 - 0.032 14.2 0.0 0.14 12.1 0.0 1.9 1 1 0 1 1 1 0 Trypsin-like peptidase domain Lip_prot_lig_C PF10437.4 ESA20861.1 - 0.092 12.4 0.1 0.79 9.4 0.0 2.4 3 0 0 3 3 3 0 Bacterial lipoate protein ligase C-terminus Sel1 PF08238.7 ESA20862.1 - 4.7e-12 46.1 2.8 1.1e-11 44.9 0.4 2.4 3 0 0 3 3 3 1 Sel1 repeat zinc-ribbons_6 PF07191.7 ESA20862.1 - 0.0026 17.4 0.8 0.0036 17.0 0.5 1.2 1 0 0 1 1 1 1 zinc-ribbons Leuk-A4-hydro_C PF09127.6 ESA20862.1 - 0.03 13.9 0.1 0.031 13.8 0.1 1.1 1 0 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal zf-RING_3 PF14369.1 ESA20862.1 - 0.13 12.2 0.8 0.91 9.5 0.0 2.1 1 1 1 2 2 2 0 zinc-finger Sel1 PF08238.7 ESA20863.1 - 8.7e-76 248.7 43.3 3e-08 34.0 0.5 13.7 14 0 0 14 14 14 13 Sel1 repeat ICAP-1_inte_bdg PF10480.4 ESA20863.1 - 0.0046 16.7 0.5 13 5.5 0.0 3.4 3 0 0 3 3 3 1 Beta-1 integrin binding protein PixA PF12306.3 ESA20863.1 - 0.024 14.5 2.1 0.44 10.3 0.1 2.9 2 1 1 3 3 3 0 Inclusion body protein MIT PF04212.13 ESA20863.1 - 0.037 13.8 7.9 4.3 7.2 0.0 5.5 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain FAD_binding_6 PF00970.19 ESA20863.1 - 0.25 11.4 0.9 1.5e+02 2.6 0.0 4.7 6 1 1 7 7 7 0 Oxidoreductase FAD-binding domain Prenyltrans_1 PF13243.1 ESA20863.1 - 0.26 11.3 12.5 3.1 7.8 0.2 4.9 3 2 2 5 5 5 0 Prenyltransferase-like TPR_11 PF13414.1 ESA20863.1 - 0.35 10.5 23.8 1.9 8.2 0.2 6.1 4 1 2 6 6 6 0 TPR repeat TPR_6 PF13174.1 ESA20863.1 - 0.79 10.3 18.2 9.3 6.9 0.0 8.2 10 0 0 10 10 10 0 Tetratricopeptide repeat Methyltransf_11 PF08241.7 ESA20865.1 - 8e-15 55.1 0.0 1.2e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA20865.1 - 2.7e-12 46.5 0.0 7.2e-12 45.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA20865.1 - 5.8e-10 39.1 0.0 9.3e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA20865.1 - 3.4e-08 32.9 0.0 8.6e-08 31.5 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA20865.1 - 1.4e-07 31.8 0.0 2.4e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA20865.1 - 1.8e-07 31.7 0.0 4.2e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA20865.1 - 2.7e-07 31.0 0.0 6e-07 29.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA20865.1 - 6.8e-07 28.8 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.13 ESA20865.1 - 0.001 18.3 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 ESA20865.1 - 0.0017 18.4 0.0 0.0033 17.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 ESA20865.1 - 0.036 14.9 0.0 0.059 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.11 ESA20865.1 - 0.042 12.1 0.1 0.37 9.0 0.0 1.9 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase LRR_3 PF07725.7 ESA20866.1 - 2.3 8.1 4.5 0.4 10.5 0.3 1.9 2 0 0 2 2 2 0 Leucine Rich Repeat PYST-C1 PF09690.5 ESA20866.1 - 3.1 7.5 9.5 7.2 6.3 6.6 1.6 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) DUF2457 PF10446.4 ESA20866.1 - 5.9 5.5 12.7 8.2 5.0 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BTB PF00651.26 ESA20868.1 - 2.3e-19 69.4 0.0 6.5e-19 67.9 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20868.1 - 3.5e-11 43.2 5.0 8.2e-11 42.0 3.5 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20868.1 - 1.4e-06 28.0 2.9 6.5e-05 22.7 0.1 3.1 2 1 2 4 4 4 2 BTB And C-terminal Kelch BTB PF00651.26 ESA20869.1 - 5.5e-19 68.1 0.0 1.5e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20869.1 - 1.2e-09 38.2 3.7 2.5e-09 37.2 2.5 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA20869.1 - 9.3e-07 28.6 2.6 9.9e-05 22.1 0.1 3.3 3 1 0 3 3 3 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA20869.1 - 0.014 14.5 0.2 0.023 13.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) TLD PF07534.11 ESA20870.1 - 1.1e-10 41.6 4.1 1.4e-10 41.3 2.9 1.1 1 0 0 1 1 1 1 TLD rve PF00665.21 ESA20872.1 - 0.0029 17.6 0.0 0.004 17.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain HTH_Tnp_Tc5 PF03221.11 ESA20873.1 - 8.8e-11 41.4 1.4 3.9e-09 36.1 0.0 2.8 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_28 PF13518.1 ESA20873.1 - 1.5e-06 28.0 1.5 7.1e-06 25.9 0.2 2.4 2 1 1 3 3 3 1 Helix-turn-helix domain BrkDBD PF09607.5 ESA20873.1 - 6.5e-06 25.6 0.6 1.4e-05 24.5 0.4 1.5 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_23 PF13384.1 ESA20873.1 - 2e-05 24.0 0.1 4.2e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA20873.1 - 8.9e-05 22.6 0.1 0.00014 21.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_IS630 PF01710.11 ESA20873.1 - 0.0091 15.6 0.2 0.013 15.1 0.2 1.4 1 0 0 1 1 1 1 Transposase CENP-B_N PF04218.8 ESA20873.1 - 0.013 14.8 0.3 0.027 13.8 0.2 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Cro PF09048.5 ESA20873.1 - 0.025 14.2 0.0 0.069 12.8 0.0 1.7 1 0 0 1 1 1 0 Cro Phage_CII PF05269.6 ESA20873.1 - 0.027 14.4 0.1 0.056 13.4 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage CII protein NUMOD1 PF07453.8 ESA20873.1 - 0.12 12.2 0.3 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 NUMOD1 domain UPF0231 PF06062.6 ESA20873.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) HTH_Tnp_1 PF01527.15 ESA20873.1 - 0.19 11.7 1.2 0.43 10.5 0.8 1.7 1 1 0 1 1 1 0 Transposase Pkinase_Tyr PF07714.12 ESA20874.1 - 4.4e-07 29.2 0.0 5.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20874.1 - 0.0013 17.9 0.0 0.0019 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF2770 PF10968.3 ESA20874.1 - 0.032 13.8 0.4 0.059 13.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2770) SLS PF14611.1 ESA20874.1 - 0.037 13.4 0.1 0.044 13.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator XLF PF09302.6 ESA20874.1 - 0.058 13.1 0.2 0.096 12.4 0.2 1.3 1 0 0 1 1 1 0 XLF (XRCC4-like factor) Cu-binding_MopE PF11617.3 ESA20874.1 - 0.088 12.5 0.2 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein metal binding site FlgN PF05130.7 ESA20874.1 - 0.15 12.3 0.1 0.2 11.8 0.1 1.1 1 0 0 1 1 1 0 FlgN protein BTB PF00651.26 ESA20875.1 - 2.3e-13 50.0 0.1 5.3e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20875.1 - 2.5e-10 40.4 1.2 2.5e-10 40.4 0.8 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20875.1 - 0.00031 20.5 0.9 0.0013 18.4 0.2 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA20875.1 - 0.065 12.3 1.3 0.09 11.9 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) AIG1 PF04548.11 ESA20877.1 - 6.6e-12 44.9 0.3 6.6e-12 44.9 0.2 2.4 3 0 0 3 3 3 1 AIG1 family Septin PF00735.13 ESA20877.1 - 1.1e-05 24.5 0.4 1.1e-05 24.5 0.3 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 ESA20877.1 - 1.1e-05 25.3 0.3 3.4e-05 23.7 0.2 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Filament PF00038.16 ESA20877.1 - 0.0012 18.4 6.9 0.0012 18.4 4.8 1.6 2 0 0 2 2 1 1 Intermediate filament protein BBP1_C PF15272.1 ESA20877.1 - 0.0015 18.0 8.6 0.0034 16.9 6.0 1.6 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal GrpE PF01025.14 ESA20877.1 - 0.0048 16.4 7.9 0.0048 16.4 5.4 2.0 2 0 0 2 2 2 1 GrpE FtsK_SpoIIIE PF01580.13 ESA20877.1 - 0.005 16.3 3.6 0.041 13.3 0.0 3.0 3 0 0 3 3 3 1 FtsK/SpoIIIE family TroA PF01297.12 ESA20877.1 - 0.0054 16.0 2.3 0.019 14.2 1.1 2.1 1 1 1 2 2 2 1 Periplasmic solute binding protein family DUF258 PF03193.11 ESA20877.1 - 0.0066 15.6 0.3 0.024 13.8 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF258 T2SE PF00437.15 ESA20877.1 - 0.018 13.9 0.1 0.073 11.9 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.1 ESA20877.1 - 0.044 13.3 0.1 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.1 ESA20877.1 - 0.048 13.8 0.2 0.15 12.1 0.0 1.9 2 1 1 3 3 3 0 AAA domain TBPIP PF07106.8 ESA20877.1 - 0.073 12.6 11.6 0.21 11.1 8.1 1.8 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Glypican PF01153.14 ESA20877.1 - 0.085 11.4 3.1 0.13 10.8 2.1 1.2 1 0 0 1 1 1 0 Glypican AAA_11 PF13086.1 ESA20877.1 - 0.28 10.7 3.5 0.16 11.5 0.9 1.8 2 0 0 2 2 2 0 AAA domain V_ATPase_I PF01496.14 ESA20877.1 - 0.31 8.8 12.3 0.65 7.7 8.2 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_18 PF13238.1 ESA20877.1 - 0.33 11.2 0.1 0.33 11.2 0.1 3.0 3 1 0 3 3 1 0 AAA domain APG6 PF04111.7 ESA20877.1 - 0.49 9.3 13.0 0.84 8.6 9.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Myb_DNA-bind_4 PF13837.1 ESA20877.1 - 0.76 9.9 7.2 0.35 11.0 3.0 2.0 2 0 0 2 2 1 0 Myb/SANT-like DNA-binding domain GTP_EFTU PF00009.22 ESA20877.1 - 0.84 9.0 4.8 0.65 9.3 0.1 2.8 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain DUF87 PF01935.12 ESA20877.1 - 0.96 9.2 0.0 0.96 9.2 0.0 3.3 2 1 0 3 3 3 0 Domain of unknown function DUF87 Snapin_Pallidin PF14712.1 ESA20877.1 - 1.3 9.3 12.0 2.7 8.3 5.0 2.8 1 1 1 2 2 2 0 Snapin/Pallidin ABC_tran PF00005.22 ESA20877.1 - 3.1 8.0 13.1 2.5e+02 1.9 9.1 2.9 1 1 0 1 1 1 0 ABC transporter DUF4337 PF14235.1 ESA20877.1 - 3.5 7.4 8.6 1.7 8.4 4.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) IncA PF04156.9 ESA20877.1 - 8.7 5.8 16.7 0.72 9.4 8.3 1.5 2 0 0 2 2 2 0 IncA protein Metal_resist PF13801.1 ESA20877.1 - 8.8 6.3 6.2 13 5.7 0.3 2.9 2 1 0 3 3 3 0 Heavy-metal resistance ubiquitin PF00240.18 ESA20878.1 - 3.8e-27 93.4 0.0 4.4e-27 93.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA20878.1 - 7.4e-13 47.9 0.0 8e-13 47.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA20878.1 - 4.5e-07 30.0 0.1 2e-06 27.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.4 ESA20878.1 - 0.024 14.8 0.0 0.029 14.5 0.0 1.1 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA20878.1 - 0.024 14.4 0.0 0.067 13.0 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Plexin_cytopl PF08337.7 ESA20878.1 - 0.07 11.4 0.2 0.46 8.7 0.0 1.9 1 1 0 2 2 2 0 Plexin cytoplasmic RasGAP domain zf-C2H2_6 PF13912.1 ESA20879.1 - 2.3e-06 27.2 35.4 0.0019 18.0 0.9 5.8 5 1 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA20879.1 - 0.00075 19.5 34.9 0.027 14.6 0.6 5.9 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 ESA20879.1 - 0.00082 19.5 51.8 0.25 11.7 0.9 6.8 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-met PF12874.2 ESA20879.1 - 0.00088 19.3 30.9 0.25 11.6 0.5 5.4 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 ESA20879.1 - 0.13 12.6 0.3 0.13 12.6 0.2 7.2 7 0 0 7 7 7 0 C2H2-type zinc finger DUF1677 PF07911.8 ESA20879.1 - 0.21 11.7 19.4 2.7 8.2 3.3 4.3 3 2 1 4 4 4 0 Protein of unknown function (DUF1677) XPA_N PF01286.13 ESA20879.1 - 0.37 10.5 13.1 11 5.7 0.1 4.6 4 0 0 4 4 4 0 XPA protein N-terminal ParB PF08775.5 ESA20879.1 - 2.1 8.6 13.4 1 9.7 3.3 2.5 2 0 0 2 2 2 0 ParB family CENP-B_dimeris PF09026.5 ESA20879.1 - 3.4 7.9 12.0 10 6.4 8.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BTB PF00651.26 ESA20880.1 - 1.9e-18 66.4 0.0 3.8e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20880.1 - 7.9e-10 38.5 4.0 4.1e-07 29.7 0.2 4.4 4 1 1 5 5 5 2 BTB And C-terminal Kelch TLD PF07534.11 ESA20880.1 - 9.7e-08 32.1 0.5 4.3e-07 30.0 0.4 2.1 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA20881.1 - 5.6e-16 58.5 0.1 1.1e-15 57.5 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA20881.1 - 7.1e-09 35.4 8.5 9.6e-07 28.5 0.8 4.3 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ESA20881.1 - 0.0017 18.3 0.1 0.022 14.7 0.0 2.6 2 0 0 2 2 2 1 TLD DUF4464 PF14713.1 ESA20883.1 - 0.051 12.9 0.5 0.059 12.7 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4464) HSP70 PF00012.15 ESA20884.1 - 0.016 13.1 0.0 0.061 11.2 0.0 1.8 2 0 0 2 2 2 0 Hsp70 protein HSP70 PF00012.15 ESA20885.1 - 1.7e-06 26.3 0.0 0.00022 19.2 0.0 2.3 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA20885.1 - 0.001 17.7 0.0 0.0069 15.0 0.0 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Kinase-like PF14531.1 ESA20885.1 - 0.02 13.8 0.0 0.036 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HSP70 PF00012.15 ESA20887.1 - 3.3e-08 31.9 0.0 6.5e-08 30.9 0.0 1.3 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA20887.1 - 2.4e-05 23.0 0.0 0.049 12.2 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein F-box-like PF12937.2 ESA20889.1 - 3.4e-08 33.0 0.8 3.4e-08 33.0 0.6 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA20889.1 - 0.014 15.0 0.1 0.039 13.6 0.1 1.8 1 0 0 1 1 1 0 F-box domain Staphostatin_A PF09022.5 ESA20890.1 - 0.55 10.0 4.6 0.2 11.4 0.2 2.5 3 0 0 3 3 3 0 Staphostatin A Pkinase_Tyr PF07714.12 ESA20892.1 - 3e-44 151.0 0.0 4.3e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20892.1 - 1.2e-43 149.1 0.0 1.8e-43 148.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA20892.1 - 0.34 10.6 1.6 0.61 9.7 1.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family HsbA PF12296.3 ESA20895.1 - 0.097 12.5 0.5 1.8 8.4 0.0 2.7 3 0 0 3 3 3 0 Hydrophobic surface binding protein A tRNA-synt_2b PF00587.20 ESA20896.1 - 8.9e-45 152.3 0.5 1.7e-44 151.4 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 ESA20896.1 - 3.4e-15 55.7 0.0 7.7e-15 54.6 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 ESA20896.1 - 5e-10 39.1 0.0 1.6e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 ESA20896.1 - 3.9e-09 36.2 0.0 9.9e-08 31.7 0.0 2.5 2 0 0 2 2 2 1 TGS domain Methyltransf_16 PF10294.4 ESA20897.1 - 5.4e-26 91.0 0.0 6.6e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 ESA20897.1 - 0.061 12.4 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SpoU_sub_bind PF08032.7 ESA20897.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding BTB PF00651.26 ESA20899.1 - 3.7e-20 71.9 0.1 4e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Skp1_POZ PF03931.10 ESA20899.1 - 0.12 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain HMG_box PF00505.14 ESA20900.1 - 5.1e-08 33.0 0.1 9.2e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF4379 PF14311.1 ESA20901.1 - 0.0034 17.1 0.5 0.0049 16.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) Haem_bd PF14376.1 ESA20901.1 - 0.1 12.3 0.1 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Haem-binding domain Arch_ATPase PF01637.13 ESA20902.1 - 4.5e-19 69.0 5.1 2.2e-18 66.8 3.5 2.0 1 1 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA20902.1 - 2.8e-07 30.7 0.0 5.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA20902.1 - 9.2e-07 29.0 0.5 0.00028 21.0 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA20902.1 - 1.3e-05 25.0 1.3 0.0085 15.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain RNA12 PF10443.4 ESA20902.1 - 2.6e-05 22.9 0.6 5.1e-05 21.9 0.4 1.5 1 1 0 1 1 1 1 RNA12 protein AAA_17 PF13207.1 ESA20902.1 - 0.00047 20.9 0.2 0.99 10.2 0.5 2.5 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 ESA20902.1 - 0.0015 17.5 0.4 0.0028 16.7 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 ESA20902.1 - 0.0038 17.4 0.4 1.3 9.2 0.2 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.10 ESA20902.1 - 0.022 14.6 0.9 0.052 13.3 0.6 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Hydrolase_3 PF08282.7 ESA20902.1 - 0.06 12.9 1.9 0.11 12.0 1.3 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NACHT PF05729.7 ESA20902.1 - 0.084 12.5 0.0 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 NACHT domain FIBP PF05427.6 ESA20903.1 - 0.056 12.6 0.5 0.074 12.2 0.3 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) LRR_8 PF13855.1 ESA20905.1 - 0.22 11.3 11.2 0.35 10.6 0.3 3.5 4 0 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 ESA20905.1 - 6 7.3 8.4 1 9.6 0.1 4.2 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.2 ESA20905.1 - 6.2 6.5 13.6 0.57 9.8 0.3 3.9 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF3439 PF11921.3 ESA20907.1 - 0.32 10.7 6.4 0.31 10.7 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF1314 PF07013.6 ESA20907.1 - 0.46 9.8 3.9 0.47 9.8 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) Dmrt1 PF12374.3 ESA20907.1 - 1.6 9.1 5.6 2.1 8.7 3.9 1.2 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 BTB PF00651.26 ESA20909.1 - 4.3e-08 33.1 0.3 6.7e-08 32.5 0.2 1.4 1 1 0 1 1 1 1 BTB/POZ domain DUF1398 PF07166.6 ESA20909.1 - 0.011 15.6 2.1 0.015 15.2 0.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1398) YhdB PF14148.1 ESA20909.1 - 0.033 13.9 2.6 1.6 8.5 0.1 3.0 2 1 1 3 3 3 0 YhdB-like protein F-box-like PF12937.2 ESA20914.1 - 0.00018 21.1 0.2 0.0002 21.0 0.1 1.1 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA20916.1 - 0.082 12.5 4.8 2 8.1 0.1 3.9 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) BTB PF00651.26 ESA20917.1 - 1.8e-19 69.7 0.5 1.8e-19 69.7 0.3 1.5 2 0 0 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.1 ESA20917.1 - 0.067 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Kelch motif Urm1 PF09138.6 ESA20917.1 - 0.16 12.1 0.6 0.34 11.0 0.1 1.8 2 1 0 2 2 2 0 Urm1 (Ubiquitin related modifier) BTB PF00651.26 ESA20918.1 - 3.6e-15 55.9 0.2 8.5e-15 54.7 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20918.1 - 1.6e-10 41.1 1.8 9.6e-10 38.5 0.7 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20918.1 - 2.5e-10 40.1 8.5 1.5e-06 27.9 0.7 4.4 3 1 1 4 4 4 3 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA20918.1 - 0.046 13.8 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain DEK_C PF08766.6 ESA20920.1 - 0.017 14.8 0.7 9.5 6.0 0.0 3.3 3 1 0 3 3 3 0 DEK C terminal domain Myb_DNA-binding PF00249.26 ESA20920.1 - 0.023 14.7 1.2 3.7 7.6 0.0 3.4 3 1 0 3 3 3 0 Myb-like DNA-binding domain DUF932 PF06067.6 ESA20920.1 - 0.08 12.2 0.9 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF932) Myb_DNA-bind_6 PF13921.1 ESA20920.1 - 0.097 12.7 4.4 3 8.0 1.7 2.9 1 1 1 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA20920.1 - 1.6 9.4 11.1 2.6 8.7 0.8 3.4 1 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain eRF1_2 PF03464.10 ESA20920.1 - 2.1 8.7 4.9 0.58 10.4 0.1 2.1 2 0 0 2 2 2 0 eRF1 domain 2 DUF972 PF06156.8 ESA20920.1 - 3.2 8.1 11.4 0.5 10.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) EBP PF05241.7 ESA20922.1 - 0.083 11.8 0.6 0.11 11.5 0.4 1.2 1 0 0 1 1 1 0 Emopamil binding protein DUF972 PF06156.8 ESA20923.1 - 0.0038 17.5 0.6 0.0053 17.0 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF972) ECH PF00378.15 ESA20928.1 - 7.6e-38 130.0 0.2 9.8e-36 123.1 0.1 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Myb_DNA-bind_4 PF13837.1 ESA20929.1 - 5.4e-06 26.4 3.5 8.5e-06 25.8 0.2 2.4 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 ESA20929.1 - 0.00025 20.8 0.7 0.00025 20.8 0.5 2.5 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain DUF4435 PF14491.1 ESA20930.1 - 0.037 13.8 6.6 0.047 13.5 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4435) DUF4298 PF14131.1 ESA20930.1 - 0.038 13.8 0.3 0.077 12.8 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4298) DUF796 PF05638.7 ESA20930.1 - 0.041 13.8 0.1 0.064 13.2 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF796) Peptidase_C10 PF01640.12 ESA20930.1 - 0.044 13.5 0.1 0.052 13.3 0.1 1.1 1 0 0 1 1 1 0 Peptidase C10 family UBN2 PF14223.1 ESA20930.1 - 0.059 13.1 0.8 1.4 8.7 0.2 2.1 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type YwpF PF14183.1 ESA20930.1 - 0.072 12.7 0.2 0.092 12.4 0.1 1.2 1 0 0 1 1 1 0 YwpF-like protein DHquinase_II PF01220.14 ESA20930.1 - 0.076 12.3 0.1 0.13 11.5 0.0 1.4 1 1 0 1 1 1 0 Dehydroquinase class II LRR_8 PF13855.1 ESA20930.1 - 1.5 8.6 12.8 5.2 6.9 0.8 3.3 1 1 3 4 4 4 0 Leucine rich repeat Sel1 PF08238.7 ESA20931.1 - 4.9e-99 322.6 42.8 4.1e-10 39.9 0.1 11.3 11 1 0 11 11 11 11 Sel1 repeat TPR_6 PF13174.1 ESA20931.1 - 3.1e-05 24.1 19.8 1.1 9.8 0.2 8.1 9 1 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA20931.1 - 0.0013 19.3 0.3 20 5.9 0.0 4.7 4 1 0 5 5 5 1 Tetratricopeptide repeat IR1-M PF12185.3 ESA20931.1 - 0.15 11.7 3.0 5.3 6.8 0.0 4.0 4 0 0 4 4 4 0 Nup358/RanBP2 E3 ligase domain TPR_17 PF13431.1 ESA20931.1 - 0.76 10.1 26.0 39 4.7 0.1 9.1 10 1 0 10 10 10 0 Tetratricopeptide repeat DUF3586 PF12131.3 ESA20931.1 - 0.98 9.5 5.3 15 5.7 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF3586) Condensin2nSMC PF12422.3 ESA20932.1 - 0.043 13.5 0.1 0.057 13.1 0.1 1.1 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit Pkinase_Tyr PF07714.12 ESA20934.1 - 1.5e-40 138.8 0.0 3.6e-40 137.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20934.1 - 6.3e-37 127.1 0.0 2.6e-36 125.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA20934.1 - 6.6e-05 22.3 0.3 0.001 18.4 0.0 2.2 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA20934.1 - 0.00058 19.6 0.0 0.00096 18.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA20934.1 - 0.017 14.3 0.5 0.038 13.2 0.3 1.6 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Complex1_LYR_2 PF13233.1 ESA20934.1 - 0.1 13.0 2.7 0.21 12.0 1.9 1.6 1 1 0 1 1 1 0 Complex1_LYR-like Kdo PF06293.9 ESA20934.1 - 0.12 11.4 0.0 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA20935.1 - 1e-25 90.3 0.0 1.1e-25 90.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20935.1 - 1e-24 87.0 0.0 1.1e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase PsbU PF06514.6 ESA20935.1 - 0.0062 16.3 0.1 0.0098 15.7 0.0 1.3 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) APH PF01636.18 ESA20935.1 - 0.043 13.5 0.2 0.068 12.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA20935.1 - 0.11 11.6 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RNase_H PF00075.19 ESA20936.1 - 0.025 14.9 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 RNase H F-box-like PF12937.2 ESA20937.1 - 1.4e-05 24.7 0.1 3.4e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 F-box-like Asp_protease PF09668.5 ESA20938.1 - 0.0024 17.4 0.0 0.0044 16.5 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease zf-BED PF02892.10 ESA20939.1 - 2.7e-09 36.6 0.2 5.7e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 BED zinc finger DBD_Tnp_Hermes PF10683.4 ESA20939.1 - 0.011 15.1 0.1 0.028 13.8 0.0 1.7 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain zf-C2H2_4 PF13894.1 ESA20939.1 - 0.097 13.0 0.3 0.73 10.3 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Nop14 PF04147.7 ESA20939.1 - 2.6 5.8 25.0 2.7 5.8 17.3 1.2 1 0 0 1 1 1 0 Nop14-like family Dimer_Tnp_hAT PF05699.9 ESA20940.1 - 2e-22 78.5 0.1 2.2e-22 78.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Peptidase_M3 PF01432.15 ESA20941.1 - 1.9e-141 472.2 0.0 2.7e-141 471.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 GDC-P PF02347.11 ESA20942.1 - 9.3e-198 657.1 1.6 1.7e-187 623.4 0.0 3.3 3 1 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.14 ESA20942.1 - 3.9e-07 29.1 0.0 9.3e-05 21.3 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.16 ESA20942.1 - 0.0016 17.6 0.7 0.004 16.3 0.0 2.0 3 0 0 3 3 3 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 ESA20942.1 - 0.071 12.0 0.0 0.2 10.5 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II F-box-like PF12937.2 ESA20945.1 - 0.00031 20.3 0.3 0.0013 18.3 0.2 2.1 1 0 0 1 1 1 1 F-box-like TLD PF07534.11 ESA20946.1 - 0.0019 18.1 0.1 0.018 15.0 0.0 2.1 1 1 1 2 2 2 1 TLD F-box-like PF12937.2 ESA20948.1 - 6.8e-06 25.7 0.4 3e-05 23.6 0.2 2.2 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA20949.1 - 0.00019 21.0 0.8 0.00067 19.3 0.6 1.9 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.1 ESA20949.1 - 5.3 6.8 12.2 6 6.7 1.4 3.8 3 1 1 4 4 4 0 Leucine rich repeat Sel1 PF08238.7 ESA20950.1 - 1.6e-130 422.6 56.3 1.9e-10 41.0 0.0 17.2 16 1 1 17 17 17 17 Sel1 repeat Aldedh PF00171.17 ESA20950.1 - 6.9e-08 31.2 0.0 0.0001 20.7 0.0 2.2 1 1 1 2 2 2 2 Aldehyde dehydrogenase family TPR_6 PF13174.1 ESA20950.1 - 0.0034 17.7 12.2 18 6.0 0.1 8.4 10 0 0 10 10 10 1 Tetratricopeptide repeat ICA69 PF04629.9 ESA20950.1 - 0.0092 15.9 2.7 0.11 12.4 2.2 2.1 2 0 0 2 2 2 1 Islet cell autoantigen ICA69, C-terminal domain TPR_16 PF13432.1 ESA20950.1 - 0.019 15.6 7.9 66 4.3 0.1 7.7 7 2 1 9 9 9 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA20950.1 - 2.6 8.4 10.4 55 4.2 0.0 6.0 6 1 1 7 7 7 0 Tetratricopeptide repeat DUF727 PF05303.7 ESA20951.1 - 0.14 11.9 0.3 0.27 11.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF727) DUF1977 PF09320.6 ESA20952.1 - 1.1e-25 89.8 0.9 2.5e-25 88.7 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.26 ESA20952.1 - 1.8e-25 88.4 0.4 4e-25 87.3 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain Sensor PF13796.1 ESA20953.1 - 3.6e-05 23.4 4.4 0.00014 21.5 3.1 1.9 1 1 0 1 1 1 1 Putative sensor DUF2207 PF09972.4 ESA20953.1 - 3.5 6.0 6.9 5.4 5.4 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BTB PF00651.26 ESA20954.1 - 1.5e-12 47.4 1.5 2.4e-12 46.8 0.3 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA20954.1 - 0.00021 21.0 0.3 0.00021 21.0 0.2 2.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch TcpE PF12648.2 ESA20955.1 - 0.078 13.1 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 TcpE family DevR PF01905.11 ESA20955.1 - 0.1 11.4 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 Pox_D5 PF03288.11 ESA20956.1 - 0.09 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Poxvirus D5 protein-like Skp1_POZ PF03931.10 ESA20956.1 - 0.14 12.2 0.3 0.82 9.8 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain NMDAR2_C PF10565.4 ESA20957.1 - 0.028 13.1 0.1 0.032 12.9 0.1 1.0 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus YccV-like PF08755.6 ESA20957.1 - 0.048 13.5 0.3 0.074 12.9 0.2 1.3 1 0 0 1 1 1 0 Hemimethylated DNA-binding protein YccV like Peptidase_S10 PF00450.17 ESA20958.1 - 3.5e-100 336.0 1.0 4.5e-100 335.7 0.7 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase dDENN PF03455.14 ESA20958.1 - 0.0066 16.5 0.0 0.037 14.1 0.0 2.3 2 0 0 2 2 2 1 dDENN domain Got1 PF04178.7 ESA20959.1 - 2e-11 44.0 7.0 2.1e-11 43.9 4.8 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF334 PF03904.8 ESA20959.1 - 0.22 10.8 1.2 0.24 10.6 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF3169 PF11368.3 ESA20959.1 - 0.97 8.5 4.8 1 8.5 3.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Herpes_UL45 PF05473.7 ESA20959.1 - 2 7.8 4.0 2.1 7.7 2.7 1.0 1 0 0 1 1 1 0 UL45 protein DUF4191 PF13829.1 ESA20959.1 - 2.6 7.1 6.2 2.6 7.0 4.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Vps5 PF09325.5 ESA20960.1 - 1.1e-25 90.3 3.9 1.7e-25 89.6 2.7 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 ESA20960.1 - 1.3e-10 41.0 0.2 3.5e-10 39.6 0.2 1.8 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.4 ESA20960.1 - 3.6e-05 23.1 1.5 6.5e-05 22.3 1.1 1.3 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein CheR PF01739.13 ESA20960.1 - 0.0016 17.7 0.4 0.0033 16.7 0.3 1.5 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain DUF2379 PF09543.5 ESA20960.1 - 0.053 13.4 0.4 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) AAA PF00004.24 ESA20961.1 - 3.8e-42 143.6 0.0 1.2e-41 141.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA20961.1 - 2.1e-06 27.9 0.1 0.00044 20.3 0.0 3.0 3 1 0 3 3 2 1 AAA domain AAA_5 PF07728.9 ESA20961.1 - 6.7e-06 25.8 0.1 6.5e-05 22.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESA20961.1 - 1.9e-05 24.6 0.0 0.00018 21.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 ESA20961.1 - 9.8e-05 22.4 0.0 0.00024 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ESA20961.1 - 0.00033 19.6 0.0 0.00064 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 ESA20961.1 - 0.0021 17.1 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 ESA20961.1 - 0.0021 18.8 0.7 0.0047 17.7 0.1 2.1 2 1 0 2 2 1 1 AAA domain Arch_ATPase PF01637.13 ESA20961.1 - 0.0022 17.7 0.4 5 6.7 0.0 3.2 2 1 1 3 3 3 1 Archaeal ATPase AAA_19 PF13245.1 ESA20961.1 - 0.0034 17.1 0.1 0.0067 16.1 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 ESA20961.1 - 0.0083 16.0 0.1 0.022 14.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain Sigma54_activ_2 PF14532.1 ESA20961.1 - 0.0088 16.1 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_28 PF13521.1 ESA20961.1 - 0.011 15.7 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 ESA20961.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 ESA20961.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA20961.1 - 0.022 14.9 0.0 0.063 13.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.6 ESA20961.1 - 0.023 14.3 0.0 0.048 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 ESA20961.1 - 0.029 13.0 0.0 0.079 11.6 0.0 1.6 2 0 0 2 2 2 0 TIP49 C-terminus IstB_IS21 PF01695.12 ESA20961.1 - 0.03 13.7 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 ESA20961.1 - 0.041 14.1 0.2 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 ESA20961.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESA20961.1 - 0.051 12.7 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESA20961.1 - 0.072 12.5 0.0 0.19 11.1 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain IPT PF01745.11 ESA20961.1 - 0.075 12.1 0.0 1.8 7.6 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase AAA_25 PF13481.1 ESA20961.1 - 0.14 11.5 0.2 0.46 9.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain Pro_isomerase PF00160.16 ESA20962.1 - 1.8e-30 106.2 0.2 3.3e-30 105.3 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.7 ESA20962.1 - 1.6e-07 30.7 0.0 1.1e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Rtf2 RING-finger U-box PF04564.10 ESA20962.1 - 0.00026 20.8 0.0 0.0085 16.0 0.0 2.7 1 1 1 2 2 2 1 U-box domain zf-Nse PF11789.3 ESA20962.1 - 0.16 11.4 0.9 2 7.9 0.7 2.4 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit VitD-bind_III PF09164.5 ESA20963.1 - 0.1 12.2 0.2 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Hormone_1 PF00103.15 ESA20963.1 - 0.11 11.8 0.5 0.15 11.4 0.3 1.2 1 0 0 1 1 1 0 Somatotropin hormone family Dynamitin PF04912.9 ESA20963.1 - 0.48 9.1 6.5 3.1 6.5 0.3 2.0 1 1 1 2 2 2 0 Dynamitin DUF4463 PF14703.1 ESA20963.1 - 0.68 10.4 3.8 1.5 9.4 2.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4463) TatD_DNase PF01026.16 ESA20964.1 - 3e-40 138.0 0.0 3.6e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase DUF3798 PF12683.2 ESA20964.1 - 0.094 11.7 0.1 0.81 8.7 0.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3798) IF4E PF01652.13 ESA20965.1 - 4.8e-20 71.7 0.6 4.8e-20 71.7 0.4 1.6 2 0 0 2 2 2 1 Eukaryotic initiation factor 4E ICAP-1_inte_bdg PF10480.4 ESA20965.1 - 0.014 15.1 1.5 0.016 15.0 1.0 1.2 1 0 0 1 1 1 0 Beta-1 integrin binding protein Med20 PF08612.6 ESA20966.1 - 0.0027 16.8 0.2 0.0034 16.5 0.1 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Syntaxin-6_N PF09177.6 ESA20966.1 - 0.065 13.6 8.0 0.32 11.4 0.2 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4160 PF13711.1 ESA20966.1 - 0.7 9.7 3.5 3.8 7.4 0.2 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4160) DUF4094 PF13334.1 ESA20966.1 - 1 9.7 5.8 0.19 12.1 0.7 2.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) Exonuc_VII_L PF02601.10 ESA20966.1 - 1.3 8.1 8.2 1.7 7.7 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit YlqD PF11068.3 ESA20966.1 - 2.4 8.1 10.8 0.85 9.6 5.1 1.9 1 1 1 2 2 2 0 YlqD protein Occludin_ELL PF07303.8 ESA20966.1 - 5.1 7.8 14.4 3 8.6 0.2 3.2 2 1 1 3 3 3 0 Occludin homology domain OmpH PF03938.9 ESA20966.1 - 8 6.3 11.3 10 6.0 7.3 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Ribosomal_L37e PF01907.14 ESA20967.1 - 1.3e-26 92.1 14.5 2.5e-26 91.2 10.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.2 ESA20967.1 - 0.00058 19.6 3.4 0.00091 19.0 2.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.13 ESA20967.1 - 0.0027 17.3 0.7 0.0038 16.9 0.5 1.4 1 1 0 1 1 1 1 SelR domain zf-RING_5 PF14634.1 ESA20967.1 - 0.08 12.6 3.6 0.12 12.1 2.5 1.3 1 0 0 1 1 1 0 zinc-RING finger domain HypA PF01155.14 ESA20967.1 - 0.12 12.0 1.3 0.16 11.6 0.9 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_2 PF13240.1 ESA20967.1 - 0.14 11.6 3.7 2.6 7.6 0.6 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4 PF00097.20 ESA20967.1 - 0.21 11.2 4.6 0.33 10.6 3.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.1 ESA20967.1 - 0.53 9.5 3.3 3.8 6.8 0.5 2.0 1 1 2 3 3 3 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 ESA20967.1 - 1.2 9.2 4.7 1.8 8.6 3.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.20 ESA20969.1 - 9.8e-25 87.1 0.0 1.2e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20969.1 - 2e-21 76.2 0.0 2.3e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA20969.1 - 0.0032 17.2 0.1 0.004 16.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA20969.1 - 0.008 15.1 0.0 0.0097 14.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 ESA20969.1 - 0.0097 15.1 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA20969.1 - 0.011 14.7 0.0 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA20969.1 - 0.05 12.9 0.0 0.065 12.5 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Sel1 PF08238.7 ESA20970.1 - 1.6e-36 123.8 23.9 3.1e-13 49.8 0.7 4.0 3 1 1 4 4 4 4 Sel1 repeat TPR_11 PF13414.1 ESA20970.1 - 0.0069 16.0 4.9 0.0069 16.0 3.4 2.9 2 1 0 3 3 3 1 TPR repeat TPR_3 PF07720.7 ESA20970.1 - 0.042 13.6 7.9 1.4 8.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Phage_DsbA PF11126.3 ESA20970.1 - 0.12 12.4 1.5 0.39 10.8 0.1 2.4 1 1 1 2 2 2 0 Transcriptional regulator DsbA TPR_6 PF13174.1 ESA20970.1 - 0.66 10.5 7.3 52 4.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA20970.1 - 1.4 8.8 15.4 1.5 8.7 3.8 3.5 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA20970.1 - 7.6 6.5 12.3 36 4.4 1.1 3.9 1 1 1 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA20971.1 - 2.4e-24 85.2 9.5 5.2e-12 45.9 0.3 2.5 3 0 0 3 3 3 2 Sel1 repeat MIT PF04212.13 ESA20971.1 - 0.013 15.3 5.3 0.76 9.7 0.3 2.8 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain Glyco_hydro_98C PF08307.6 ESA20971.1 - 0.024 13.9 0.4 0.024 13.9 0.3 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 C-terminal domain TPR_11 PF13414.1 ESA20971.1 - 0.099 12.3 3.1 0.63 9.7 0.4 2.3 1 1 1 2 2 2 0 TPR repeat TPR_12 PF13424.1 ESA20971.1 - 0.22 11.4 4.1 3.8 7.5 2.3 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA20971.1 - 0.28 10.8 7.4 1.7 8.3 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA20971.1 - 0.71 9.9 8.2 1.2 9.2 0.1 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat F-box-like PF12937.2 ESA20972.1 - 0.0018 17.9 0.3 0.0054 16.4 0.2 1.8 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.2 ESA20973.1 - 0.12 12.0 3.1 1.9 8.1 0.7 2.6 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) BTB PF00651.26 ESA20974.1 - 1.9e-17 63.2 0.1 4.1e-17 62.1 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA20974.1 - 7.2e-11 42.2 4.3 7.6e-11 42.1 1.6 2.1 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA20974.1 - 0.00029 20.6 4.3 0.00038 20.2 1.2 2.4 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA20975.1 - 0.00025 21.0 3.8 0.0035 17.3 2.7 2.0 1 1 0 1 1 1 1 TLD Pox_D5 PF03288.11 ESA20977.1 - 0.0014 18.8 0.0 0.0039 17.4 0.0 1.8 1 0 0 1 1 1 1 Poxvirus D5 protein-like Sda PF08970.5 ESA20977.1 - 0.039 13.4 0.2 0.091 12.2 0.1 1.6 1 0 0 1 1 1 0 Sporulation inhibitor A RMF PF04957.7 ESA20978.1 - 0.4 10.4 2.8 0.77 9.5 1.9 1.6 1 1 0 1 1 1 0 Ribosome modulation factor BTB_2 PF02214.17 ESA20980.1 - 3.1e-07 30.5 0.1 6.6e-07 29.4 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain NAD_binding_1 PF00175.16 ESA20981.1 - 0.0013 19.3 0.1 0.0015 19.0 0.0 1.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Sel1 PF08238.7 ESA20985.1 - 8.3e-36 121.6 18.3 5.7e-11 42.6 2.4 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA20985.1 - 0.5 10.9 11.6 9 7.0 0.1 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA20985.1 - 1.6 8.9 9.8 0.48 10.5 1.0 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 ESA20985.1 - 2 8.4 6.4 7.9 6.5 0.3 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 ESA20986.1 - 1.9e-35 122.2 0.5 2.5e-35 121.9 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20986.1 - 1.3e-34 119.4 0.1 1.6e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA20986.1 - 5.8e-05 22.5 1.6 0.00024 20.5 0.2 2.1 1 1 0 2 2 2 1 RIO1 family WaaY PF06176.6 ESA20986.1 - 0.00026 20.3 0.5 0.00038 19.7 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA20986.1 - 0.00075 18.8 0.4 0.0021 17.4 0.3 1.7 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 ESA20986.1 - 0.001 18.1 0.1 0.72 8.7 0.0 2.1 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 ESA20986.1 - 0.0022 17.7 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA20986.1 - 0.0054 15.8 0.1 0.0071 15.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA20987.1 - 1.9e-40 138.6 0.2 1.4e-37 129.2 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA20987.1 - 2.5e-38 131.6 0.0 1.5e-27 96.3 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase WaaY PF06176.6 ESA20987.1 - 0.0058 15.8 0.1 0.0096 15.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA20987.1 - 0.007 15.7 0.6 0.016 14.5 0.4 1.6 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA20987.1 - 0.0073 15.3 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA20987.1 - 0.058 13.1 0.2 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Herpes_UL52 PF03121.10 ESA20988.1 - 0.11 12.2 1.5 4.6 7.0 0.2 2.5 1 1 1 2 2 2 0 Herpesviridae UL52/UL70 DNA primase PLAC8 PF04749.12 ESA20989.1 - 9.3e-19 67.9 15.8 1.1e-18 67.6 11.0 1.1 1 0 0 1 1 1 1 PLAC8 family CH PF00307.26 ESA20990.1 - 1e-06 28.7 0.4 3.2e-06 27.1 0.3 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain Mpv17_PMP22 PF04117.7 ESA20990.1 - 0.14 11.8 1.1 0.29 10.8 0.1 2.0 2 0 0 2 2 2 0 Mpv17 / PMP22 family DUF912 PF06024.7 ESA20990.1 - 2.8 8.0 6.1 0.65 10.0 0.1 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Pkinase_Tyr PF07714.12 ESA20991.1 - 7.9e-32 110.3 0.0 1.4e-31 109.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA20991.1 - 4.2e-30 104.7 0.0 9.2e-30 103.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DBD_Tnp_Mut PF03108.10 ESA20992.1 - 3.2e-05 23.3 0.1 0.00012 21.5 0.0 1.8 1 1 1 2 2 2 1 MuDR family transposase Nitr_red_assoc PF09655.5 ESA20993.1 - 0.076 13.3 0.0 0.081 13.2 0.0 1.1 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) HTH_Tnp_Tc5 PF03221.11 ESA20994.1 - 1.6e-13 50.2 0.1 3e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA20994.1 - 0.0036 16.4 0.0 0.013 14.6 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF925 PF06042.6 ESA20994.1 - 0.063 12.8 0.1 0.084 12.4 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF925) MAT1 PF06391.8 ESA20996.1 - 1.4e-29 103.1 26.6 3.1e-29 102.0 18.5 1.5 1 1 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-RING_5 PF14634.1 ESA20996.1 - 2.7e-06 27.0 7.0 8.8e-06 25.3 5.1 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 ESA20996.1 - 5e-06 26.0 7.6 9.7e-06 25.1 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA20996.1 - 5.9e-06 25.8 5.8 1e-05 25.0 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA20996.1 - 5.1e-05 23.0 6.1 9.8e-05 22.1 4.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA20996.1 - 8.4e-05 22.5 8.1 0.00016 21.6 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA20996.1 - 0.0063 16.2 4.8 0.067 12.9 3.2 2.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA20996.1 - 0.0069 16.2 5.8 0.11 12.4 4.8 2.3 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 ESA20996.1 - 0.0085 16.1 2.2 0.02 14.9 1.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_4 PF14570.1 ESA20996.1 - 0.0095 15.4 9.7 0.29 10.7 7.5 2.2 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-UDP PF14569.1 ESA20996.1 - 0.059 13.1 1.5 0.12 12.1 1.1 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-Apc11 PF12861.2 ESA20996.1 - 0.081 12.7 1.7 0.17 11.7 1.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Selenoprotein_S PF06936.6 ESA20996.1 - 0.11 12.0 10.0 0.2 11.1 6.9 1.4 1 0 0 1 1 1 0 Selenoprotein S (SelS) RecR PF02132.10 ESA20996.1 - 2.3 7.7 5.3 3.4 7.1 0.1 2.6 2 0 0 2 2 2 0 RecR protein Lipoprotein_10 PF03202.8 ESA20996.1 - 6.7 6.7 11.1 17 5.4 7.7 1.8 1 1 0 1 1 1 0 Putative mycoplasma lipoprotein, C-terminal region Ribosomal_L1 PF00687.16 ESA20997.1 - 5.8e-26 91.1 0.5 7.4e-26 90.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Peroxin-13_N PF04088.8 ESA20998.1 - 2.3e-47 160.8 0.9 8.5e-47 159.0 0.6 1.9 1 1 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.23 ESA20998.1 - 2.1e-15 55.8 0.4 4.6e-15 54.7 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 ESA20998.1 - 1.6e-12 46.8 0.0 3.3e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA20998.1 - 1.2e-11 43.9 0.0 2.5e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Actin PF00022.14 ESA20999.1 - 2.7e-136 454.1 0.0 3e-136 453.9 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESA20999.1 - 0.082 11.4 0.0 0.79 8.2 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein RGS PF00615.14 ESA21000.1 - 1.9e-13 50.5 0.3 1.9e-11 44.1 0.1 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF1625 PF07787.7 ESA21000.1 - 0.44 9.7 2.4 16 4.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1625) DUF4181 PF13789.1 ESA21000.1 - 0.78 9.6 8.6 0.55 10.1 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) Orthopox_B11R PF07033.6 ESA21002.1 - 0.23 10.9 1.9 0.27 10.7 0.5 1.6 1 1 1 2 2 2 0 Orthopoxvirus B11R protein Acetyltransf_13 PF13880.1 ESA21003.1 - 4e-20 71.3 0.0 8.4e-20 70.2 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 ESA21003.1 - 8.1e-15 54.1 0.5 2e-14 52.8 0.3 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_5 PF13444.1 ESA21003.1 - 0.14 12.7 0.1 2.2 8.9 0.0 2.4 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Aldedh PF00171.17 ESA21004.1 - 3.3e-107 358.7 0.0 4e-107 358.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sel1 PF08238.7 ESA21005.1 - 5.8e-49 163.4 18.9 2.6e-12 46.9 1.3 5.2 5 0 0 5 5 5 5 Sel1 repeat DUF977 PF06163.6 ESA21005.1 - 0.025 14.3 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF977) NSF PF02071.15 ESA21005.1 - 0.42 11.3 5.6 1.1e+02 4.1 0.1 4.5 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_10 PF13374.1 ESA21005.1 - 1.4 8.9 6.7 4.2 7.4 1.9 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA21005.1 - 4 8.1 12.1 3.2 8.4 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA21005.1 - 9 6.2 14.3 6.7 6.6 0.2 4.4 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA21007.1 - 5.9e-42 141.1 15.0 7.5e-10 39.1 0.5 5.1 5 0 0 5 5 5 5 Sel1 repeat DUF977 PF06163.6 ESA21007.1 - 0.044 13.5 0.0 0.24 11.1 0.0 2.0 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF977) TPR_11 PF13414.1 ESA21007.1 - 0.084 12.5 11.4 0.078 12.6 1.2 3.1 2 1 1 3 3 3 0 TPR repeat TPR_7 PF13176.1 ESA21007.1 - 0.32 10.8 1.6 7.5 6.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 ESA21007.1 - 8.3 7.4 7.9 4.7 8.2 0.1 4.1 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat E1_DerP2_DerF2 PF02221.10 ESA21008.1 - 5.3e-08 33.1 0.4 6.2e-08 32.9 0.3 1.1 1 0 0 1 1 1 1 ML domain Big_3_2 PF12245.3 ESA21008.1 - 0.042 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Big_3_4 PF13754.1 ESA21008.1 - 0.76 10.1 9.0 0.36 11.2 0.3 2.6 2 2 0 2 2 2 0 Bacterial Ig-like domain (group 3) BTB PF00651.26 ESA21009.1 - 4e-12 46.1 0.0 1.1e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21009.1 - 9.1e-11 41.9 0.7 9.1e-11 41.9 0.5 2.1 2 0 0 2 2 2 1 TLD LRR_8 PF13855.1 ESA21011.1 - 0.21 11.3 8.1 0.18 11.6 1.1 3.4 3 0 0 3 3 3 0 Leucine rich repeat DUF1388 PF07142.7 ESA21013.1 - 0.15 11.7 8.6 0.18 11.5 1.7 3.1 2 1 1 3 3 3 0 Repeat of unknown function (DUF1388) PTR2 PF00854.16 ESA21015.1 - 8.6e-56 189.3 18.3 3.1e-31 108.4 5.2 2.2 1 1 1 2 2 2 2 POT family MFS_1 PF07690.11 ESA21015.1 - 1.1e-11 44.0 31.5 7e-10 38.1 15.5 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Ninjurin PF04923.7 ESA21015.1 - 0.055 13.1 0.8 1.4 8.6 0.0 2.9 3 0 0 3 3 3 0 Ninjurin DUF1469 PF07332.6 ESA21015.1 - 0.91 9.2 10.8 2.2 7.9 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1469) Aldedh PF00171.17 ESA21017.1 - 7.7e-125 416.8 0.0 9.5e-125 416.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 ESA21017.1 - 0.017 14.3 0.1 0.042 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) RRM_1 PF00076.17 ESA21018.1 - 3.5e-15 55.3 0.0 1.2e-14 53.7 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA21018.1 - 1.2e-09 37.9 0.1 5.8e-09 35.6 0.0 2.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA21018.1 - 5.4e-09 35.9 0.0 8.6e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA21018.1 - 3.6e-05 23.5 0.0 5.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.1 ESA21018.1 - 0.00038 20.1 0.0 0.00068 19.3 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif ABC_tran PF00005.22 ESA21019.1 - 4.3e-07 30.2 0.6 7.1e-07 29.6 0.4 1.7 1 1 0 1 1 1 1 ABC transporter AIG1 PF04548.11 ESA21019.1 - 6.1e-07 28.7 1.1 9.4e-07 28.1 0.5 1.4 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA21019.1 - 9.4e-07 28.7 0.1 2.8e-06 27.2 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 ESA21019.1 - 0.00017 20.8 0.4 0.00023 20.4 0.2 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 ESA21019.1 - 0.00033 19.8 1.2 0.00057 19.1 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA21019.1 - 0.00035 21.3 1.3 0.00099 19.9 0.8 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA21019.1 - 0.0008 19.7 5.1 0.019 15.2 3.6 2.4 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 ESA21019.1 - 0.0011 17.9 0.1 0.0019 17.1 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.12 ESA21019.1 - 0.0013 18.6 0.9 0.012 15.4 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_10 PF12846.2 ESA21019.1 - 0.0039 16.6 0.0 0.0067 15.9 0.0 1.5 2 0 0 2 2 2 1 AAA-like domain Septin PF00735.13 ESA21019.1 - 0.0088 15.0 0.8 0.013 14.5 0.1 1.6 2 0 0 2 2 2 1 Septin AAA_29 PF13555.1 ESA21019.1 - 0.011 15.2 0.4 0.021 14.3 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 ESA21019.1 - 0.021 14.3 0.4 0.036 13.5 0.3 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_21 PF13304.1 ESA21019.1 - 0.03 14.2 3.9 0.12 12.2 2.7 1.9 1 1 0 1 1 1 0 AAA domain Guanylate_kin PF00625.16 ESA21019.1 - 0.032 13.6 0.2 4.4 6.7 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase Mg_chelatase PF01078.16 ESA21019.1 - 0.043 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Miro PF08477.8 ESA21019.1 - 0.062 13.8 0.6 0.28 11.6 0.1 2.1 1 1 2 3 3 3 0 Miro-like protein IstB_IS21 PF01695.12 ESA21019.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Ras PF00071.17 ESA21019.1 - 0.064 12.6 0.1 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Ras family AAA_5 PF07728.9 ESA21019.1 - 0.064 12.9 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.22 ESA21019.1 - 0.065 12.6 0.2 0.15 11.5 0.1 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain NACHT PF05729.7 ESA21019.1 - 0.069 12.8 1.6 0.27 10.8 0.4 2.4 1 1 0 2 2 2 0 NACHT domain AAA_23 PF13476.1 ESA21019.1 - 0.069 13.4 8.7 0.13 12.5 6.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA21019.1 - 0.079 12.9 0.2 0.12 12.3 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.17 ESA21019.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 ESA21019.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Dynamin_N PF00350.18 ESA21019.1 - 1.8 8.3 6.3 2 8.2 0.5 2.6 2 2 0 2 2 2 0 Dynamin family TM1586_NiRdase PF14512.1 ESA21020.1 - 0.0057 15.8 0.0 0.0091 15.1 0.0 1.4 1 0 0 1 1 1 1 Putative TM nitroreductase Neuregulin PF02158.10 ESA21020.1 - 0.12 11.1 0.4 0.14 10.8 0.3 1.1 1 0 0 1 1 1 0 Neuregulin family LRR_4 PF12799.2 ESA21021.1 - 8.1e-12 44.4 54.0 0.0025 17.3 2.0 9.1 1 1 7 8 8 8 6 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESA21021.1 - 4.3e-05 23.0 48.0 4 8.0 0.2 12.3 9 4 1 10 10 10 4 Leucine rich repeat LRR_1 PF00560.28 ESA21021.1 - 0.00012 21.6 50.1 1.4 9.1 0.4 11.4 3 2 7 10 10 10 7 Leucine Rich Repeat LRR_8 PF13855.1 ESA21021.1 - 0.00018 21.2 44.2 0.43 10.3 6.3 6.5 1 1 5 6 6 6 6 Leucine rich repeat LRR_6 PF13516.1 ESA21021.1 - 0.19 11.9 49.8 0.66 10.2 1.1 11.4 6 5 1 7 7 7 0 Leucine Rich repeat DUF2572 PF10833.3 ESA21022.1 - 0.03 13.7 0.8 0.032 13.6 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Dynactin_p22 PF07426.6 ESA21022.1 - 0.061 12.6 0.4 0.071 12.3 0.3 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 GMC_oxred_C PF05199.8 ESA21025.1 - 5.1e-14 52.7 0.0 1.8e-13 51.0 0.0 2.0 1 0 0 1 1 1 1 GMC oxidoreductase Abhydrolase_5 PF12695.2 ESA21025.1 - 8.8e-10 38.5 0.0 3.7e-09 36.4 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA21025.1 - 7.6e-06 25.9 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family GMC_oxred_N PF00732.14 ESA21025.1 - 0.01 15.0 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase DMPK_coil PF08826.5 ESA21026.1 - 0.3 11.0 1.0 21 5.1 0.0 3.4 3 0 0 3 3 3 0 DMPK coiled coil domain like Rep_fac-A_C PF08646.5 ESA21026.1 - 0.43 10.2 20.6 0.18 11.4 1.0 3.5 3 0 0 3 3 3 0 Replication factor-A C terminal domain F-box-like PF12937.2 ESA21027.1 - 0.00095 18.8 2.3 0.0012 18.5 0.7 1.9 2 0 0 2 2 2 1 F-box-like SNARE_assoc PF09335.6 ESA21028.1 - 2.1e-19 69.9 3.3 3.4e-19 69.2 2.3 1.3 1 0 0 1 1 1 1 SNARE associated Golgi protein Fijivirus_P9-2 PF06837.6 ESA21028.1 - 0.089 11.9 2.0 0.17 10.9 0.1 2.0 2 0 0 2 2 2 0 Fijivirus P9-2 protein Hpt PF01627.18 ESA21029.1 - 1.8e-11 43.8 0.0 2.9e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Hpt domain Pkinase_Tyr PF07714.12 ESA21031.1 - 0.0014 17.7 0.0 0.0069 15.4 0.0 1.9 1 1 1 2 2 2 1 Protein tyrosine kinase DUF1542 PF07564.6 ESA21031.1 - 0.0091 15.9 1.1 0.02 14.9 0.3 1.9 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1542) NinF PF05810.7 ESA21031.1 - 0.044 13.5 2.8 0.096 12.5 1.9 1.6 1 0 0 1 1 1 0 NinF protein DUF148 PF02520.12 ESA21031.1 - 0.11 12.2 0.2 0.31 10.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF1542 PF07564.6 ESA21032.1 - 0.1 12.6 0.9 0.1 12.6 0.6 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1542) DUF4546 PF15079.1 ESA21032.1 - 0.57 9.2 3.7 0.91 8.6 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4546) LAGLIDADG_1 PF00961.14 ESA21033.1 - 0.86 10.1 10.3 5.1 7.6 1.4 2.5 2 0 0 2 2 2 0 LAGLIDADG endonuclease TIR-like PF10137.4 ESA21035.1 - 0.032 13.8 0.2 0.082 12.5 0.0 1.7 2 0 0 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain Sel1 PF08238.7 ESA21036.1 - 1.2e-91 299.1 40.3 5.4e-11 42.7 0.1 12.4 13 0 0 13 13 13 12 Sel1 repeat TPR_6 PF13174.1 ESA21036.1 - 1.7e-05 24.9 15.0 0.46 11.0 0.0 7.6 8 1 0 8 8 8 2 Tetratricopeptide repeat Sushi_2 PF09014.5 ESA21036.1 - 0.043 13.5 1.0 4.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain MIT PF04212.13 ESA21036.1 - 5.9 6.8 32.4 2.2 8.2 0.3 7.5 7 1 0 8 8 8 0 MIT (microtubule interacting and transport) domain DUF3996 PF13161.1 ESA21037.1 - 0.0027 17.3 0.6 0.0035 16.9 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3996) Exo_endo_phos_2 PF14529.1 ESA21038.1 - 2e-11 43.5 0.2 2e-11 43.5 0.1 3.2 4 1 0 4 4 4 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA21038.1 - 6.7e-10 39.3 0.0 9.9e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cys_Met_Meta_PP PF01053.15 ESA21039.1 - 0.00019 19.8 0.0 0.0002 19.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF2095 PF09868.4 ESA21039.1 - 0.086 12.6 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) Cys_Met_Meta_PP PF01053.15 ESA21040.1 - 0.0073 14.6 0.0 0.011 14.1 0.0 1.3 1 1 1 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme TLD PF07534.11 ESA21042.1 - 3.6e-07 30.2 0.4 2e-06 27.8 0.0 2.4 2 1 1 3 3 3 1 TLD PPR_2 PF13041.1 ESA21043.1 - 2e-28 98.0 30.8 9.4e-06 25.5 0.3 10.2 7 3 4 11 11 11 9 PPR repeat family PPR_3 PF13812.1 ESA21043.1 - 5.4e-12 44.9 0.0 0.12 12.7 0.0 9.4 12 0 0 12 12 12 1 Pentatricopeptide repeat domain PPR PF01535.15 ESA21043.1 - 1.1e-10 40.7 23.6 0.017 15.0 0.0 11.2 13 0 0 13 13 13 4 PPR repeat PPR_1 PF12854.2 ESA21043.1 - 6.3e-08 31.9 8.5 0.0051 16.2 0.0 7.2 8 0 0 8 8 8 2 PPR repeat TPR_2 PF07719.12 ESA21043.1 - 0.056 13.3 1.0 2.6 8.1 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Marek_A PF02124.10 ESA21043.1 - 0.13 11.6 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Marek's disease glycoprotein A Dimer_Tnp_hAT PF05699.9 ESA21044.1 - 3.2e-10 39.4 0.0 3.5e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA21045.1 - 4.9e-10 39.3 2.2 6.5e-10 38.9 0.8 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4413) DUF3452 PF11934.3 ESA21045.1 - 0.01 15.1 0.3 0.052 12.8 0.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3452) Shugoshin_N PF07558.6 ESA21046.1 - 0.79 9.4 6.7 0.2 11.3 1.3 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region KLRAQ PF10205.4 ESA21046.1 - 2.5 8.2 7.6 0.2 11.7 0.6 2.6 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein DLIC PF05783.6 ESA21048.1 - 0.056 12.1 0.7 0.046 12.3 0.5 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Ribosomal_L34e PF01199.13 ESA21050.1 - 2.9e-36 123.5 6.0 3.1e-36 123.4 4.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L34e Zn_ribbon_recom PF13408.1 ESA21050.1 - 4.5 7.6 6.7 1.1 9.5 2.5 1.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Pkinase PF00069.20 ESA21051.1 - 4.3e-53 180.1 0.5 8.6e-53 179.1 0.3 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21051.1 - 7.3e-25 87.5 0.3 5e-23 81.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 ESA21051.1 - 0.00038 19.3 0.2 0.00059 18.7 0.2 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase RIO1 PF01163.17 ESA21051.1 - 0.0018 17.6 0.4 0.12 11.6 0.0 2.3 1 1 1 2 2 2 2 RIO1 family rRNA_processing PF08524.6 ESA21053.1 - 1.9e-13 50.4 33.0 1.8e-10 40.7 22.9 2.1 1 1 0 1 1 1 1 rRNA processing DDHD PF02862.12 ESA21053.1 - 0.46 10.2 6.2 0.6 9.8 4.3 1.3 1 0 0 1 1 1 0 DDHD domain GSIII_N PF12437.3 ESA21054.1 - 4.3e-66 221.3 0.2 7.2e-66 220.6 0.1 1.3 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C PF00120.19 ESA21054.1 - 1.5e-34 119.3 0.0 2.3e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Pkinase_Tyr PF07714.12 ESA21056.1 - 1.3e-24 86.6 0.0 1.8e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21056.1 - 2.8e-24 85.6 0.6 5.2e-24 84.8 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pox_J1 PF03338.10 ESA21056.1 - 0.018 14.7 0.1 0.069 12.8 0.0 1.9 2 0 0 2 2 2 0 Poxvirus J1 protein Kdo PF06293.9 ESA21056.1 - 0.045 12.8 0.0 5 6.1 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA21056.1 - 0.053 13.0 4.6 0.16 11.4 0.4 2.3 2 1 0 2 2 2 0 Choline/ethanolamine kinase cNMP_binding PF00027.24 ESA21057.1 - 1.7e-24 85.4 0.7 3.1e-12 46.1 0.0 5.6 4 1 0 4 4 4 4 Cyclic nucleotide-binding domain Patatin PF01734.17 ESA21057.1 - 1.4e-20 74.1 1.5 5.8e-20 72.0 1.0 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase DUF2267 PF10025.4 ESA21057.1 - 0.019 15.0 0.0 0.063 13.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) MT-A70 PF05063.9 ESA21059.1 - 5.1e-12 45.7 0.3 8.8e-12 44.9 0.2 1.4 1 0 0 1 1 1 1 MT-A70 eIF-5a PF01287.15 ESA21062.1 - 2e-19 69.3 0.5 2.7e-19 68.8 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 ESA21062.1 - 0.0066 16.1 0.1 0.016 14.9 0.1 1.7 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 ESA21062.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain MARVEL PF01284.18 ESA21063.1 - 0.97 9.2 10.7 3.7 7.3 7.5 1.8 1 1 0 1 1 1 0 Membrane-associating domain Adaptin_N PF01602.15 ESA21064.1 - 5.7e-49 166.8 4.8 6.9e-49 166.5 3.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 ESA21064.1 - 5.8e-06 26.4 2.6 0.024 14.9 0.3 4.2 2 1 3 5 5 5 2 HEAT repeats MethyTransf_Reg PF10119.4 ESA21064.1 - 0.012 16.0 0.3 0.12 12.8 0.0 2.6 3 0 0 3 3 3 0 Predicted methyltransferase regulatory domain Cnd1 PF12717.2 ESA21064.1 - 0.034 14.0 3.7 3 7.6 2.6 3.0 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 ESA21064.1 - 0.96 10.0 3.5 4.4 7.9 0.2 3.6 3 2 2 5 5 5 0 HEAT-like repeat DUF3704 PF12488.3 ESA21066.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) Rifin_STEVOR PF02009.11 ESA21067.1 - 0.00031 20.4 1.1 0.00036 20.2 0.8 1.0 1 0 0 1 1 1 1 Rifin/stevor family SSP160 PF06933.6 ESA21067.1 - 0.004 15.2 8.5 0.0042 15.1 5.9 1.0 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 TMEM154 PF15102.1 ESA21067.1 - 0.0052 16.5 0.4 0.006 16.3 0.3 1.1 1 0 0 1 1 1 1 TMEM154 protein family IncA PF04156.9 ESA21067.1 - 0.0061 16.1 0.1 0.0084 15.7 0.0 1.2 1 0 0 1 1 1 1 IncA protein DUF912 PF06024.7 ESA21067.1 - 0.019 14.9 0.0 0.022 14.8 0.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Herpes_gE PF02480.11 ESA21067.1 - 0.019 13.2 0.4 0.021 13.0 0.3 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Shisa PF13908.1 ESA21067.1 - 0.026 14.7 0.1 0.031 14.4 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Cytomega_TRL10 PF06084.6 ESA21067.1 - 0.088 12.6 0.4 0.11 12.3 0.3 1.2 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein DUF2207 PF09972.4 ESA21067.1 - 0.11 11.0 0.1 0.12 10.9 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF508 PF04370.7 ESA21067.1 - 0.29 10.7 3.0 0.4 10.2 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Med3 PF11593.3 ESA21067.1 - 0.94 8.6 7.4 1 8.5 5.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Dmrt1 PF12374.3 ESA21067.1 - 2.6 8.4 8.1 3.7 7.9 5.6 1.2 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 SPT16 PF08644.6 ESA21068.1 - 0.0013 18.5 0.2 0.1 12.4 0.1 2.5 2 0 0 2 2 2 2 FACT complex subunit (SPT16/CDC68) Csm1 PF12539.3 ESA21069.1 - 0.0098 16.3 0.6 0.11 12.9 0.1 2.5 2 1 0 2 2 2 1 Chromosome segregation protein Csm1/Pcs1 Pkinase_Tyr PF07714.12 ESA21071.1 - 4.6e-50 170.1 0.0 6.5e-50 169.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21071.1 - 1.2e-45 155.7 0.2 1.9e-45 155.0 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA21071.1 - 6.7e-43 144.1 11.7 4.3e-11 43.0 1.5 5.7 6 0 0 6 6 6 5 Sel1 repeat Kinase-like PF14531.1 ESA21071.1 - 2.3e-05 23.5 0.0 5.7e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 ESA21071.1 - 0.0003 20.1 0.2 0.00082 18.7 0.2 1.7 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA21071.1 - 0.015 14.3 0.0 0.026 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_11 PF13414.1 ESA21071.1 - 0.022 14.3 11.8 0.37 10.4 0.4 4.1 1 1 3 4 4 4 0 TPR repeat MIT PF04212.13 ESA21071.1 - 1 9.3 12.2 3 7.8 1.4 4.1 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain zinc-ribbons_6 PF07191.7 ESA21073.1 - 0.038 13.7 0.5 0.056 13.2 0.3 1.2 1 0 0 1 1 1 0 zinc-ribbons zf-C2H2_jaz PF12171.3 ESA21073.1 - 2.5 8.3 6.0 0.61 10.3 0.5 2.2 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding CRCB PF02537.10 ESA21074.1 - 0.081 12.8 0.1 0.081 12.8 0.1 1.1 1 0 0 1 1 1 0 CrcB-like protein ubiquitin PF00240.18 ESA21075.1 - 1e-13 50.4 0.0 2e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 ESA21075.1 - 1.2e-08 34.5 0.1 2.2e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA21075.1 - 0.0037 17.4 0.0 0.017 15.3 0.0 2.0 2 1 0 2 2 2 1 Ubiquitin-like domain PARP PF00644.15 ESA21075.1 - 0.015 14.7 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain Rad60-SLD_2 PF13881.1 ESA21075.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TLD PF07534.11 ESA21076.1 - 7.7e-14 51.8 0.8 7.7e-14 51.8 0.6 2.4 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA21076.1 - 7.7e-13 48.4 0.2 1.8e-12 47.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21076.1 - 1.5e-05 24.7 1.2 7.5e-05 22.5 0.2 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch F-box-like PF12937.2 ESA21077.1 - 8.2e-06 25.4 1.2 3.4e-05 23.4 0.3 2.2 2 0 0 2 2 2 1 F-box-like Borrelia_rep PF03183.8 ESA21077.1 - 2.5 8.0 5.4 0.97 9.3 1.3 2.3 2 0 0 2 2 2 0 Borrelia repeat protein Sel1 PF08238.7 ESA21079.1 - 1.1e-60 200.6 16.5 4.6e-12 46.1 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA21079.1 - 0.003 17.9 11.0 0.34 11.4 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA21079.1 - 0.039 14.1 14.2 0.18 12.1 0.8 5.5 3 2 4 7 7 7 0 Tetratricopeptide repeat DDE_1 PF03184.14 ESA21080.1 - 0.0014 17.7 0.1 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease GBP_repeat PF02526.9 ESA21080.1 - 0.063 12.6 0.3 0.13 11.6 0.2 1.6 1 0 0 1 1 1 0 Glycophorin-binding protein Pkinase_Tyr PF07714.12 ESA21081.1 - 5e-32 110.9 0.0 8.1e-24 84.0 0.0 2.5 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21081.1 - 2.2e-23 82.7 0.0 3.2e-19 69.1 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain DUF3233 PF11557.3 ESA21081.1 - 0.018 13.8 0.1 0.028 13.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3233) Toxin_46 PF15526.1 ESA21081.1 - 0.038 14.1 0.8 36 4.6 0.0 3.9 3 1 0 3 3 3 0 Putative toxin 46 BTB PF00651.26 ESA21082.1 - 2.5e-09 37.0 0.1 4.3e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4263 PF14082.1 ESA21082.1 - 0.024 14.5 1.6 0.43 10.4 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4263) Erp_C PF06780.6 ESA21083.1 - 0.025 14.4 4.1 0.051 13.4 2.9 1.4 1 0 0 1 1 1 0 Erp protein C-terminus Cytochrom_B_C PF00032.12 ESA21083.1 - 0.55 10.4 6.8 0.58 10.4 2.3 2.4 1 1 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD LLGL PF08366.8 ESA21084.1 - 0.042 13.7 0.0 0.047 13.5 0.0 1.1 1 0 0 1 1 1 0 LLGL2 DAP_C PF07932.7 ESA21084.1 - 0.1 12.7 0.0 1.1 9.3 0.0 2.0 1 1 1 2 2 2 0 D-aminopeptidase, domain C DDE_1 PF03184.14 ESA21085.1 - 6.8e-12 44.9 0.1 1.3e-11 44.0 0.1 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease TryThrA_C PF12319.3 ESA21085.1 - 0.028 13.5 0.8 0.033 13.3 0.5 1.2 1 0 0 1 1 1 0 Tryptophan-Threonine-rich plasmodium antigen C terminal Lac_bphage_repr PF06543.7 ESA21085.1 - 0.068 12.7 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Cas_NE0113 PF09623.5 ESA21087.1 - 0.0027 17.1 0.4 0.0032 16.9 0.3 1.2 1 0 0 1 1 1 1 CRISPR-associated protein NE0113 (Cas_NE0113) Tropomyosin_1 PF12718.2 ESA21087.1 - 0.014 15.2 6.0 0.44 10.3 1.5 2.1 1 1 1 2 2 2 0 Tropomyosin like CHD5 PF04420.9 ESA21087.1 - 0.052 13.2 0.9 0.078 12.6 0.5 1.6 1 1 0 1 1 1 0 CHD5-like protein COG2 PF06148.6 ESA21087.1 - 0.068 13.0 2.5 0.09 12.6 1.7 1.2 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 IncA PF04156.9 ESA21087.1 - 0.49 9.9 5.7 0.56 9.7 3.9 1.1 1 0 0 1 1 1 0 IncA protein Fzo_mitofusin PF04799.8 ESA21087.1 - 0.58 9.5 2.5 5.8 6.2 0.1 2.0 1 1 1 2 2 2 0 fzo-like conserved region DUF4404 PF14357.1 ESA21087.1 - 0.86 10.0 4.8 4 7.9 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) HalX PF08663.5 ESA21087.1 - 1.5 8.8 6.0 8.6 6.4 0.9 2.6 1 1 1 2 2 2 0 HalX domain LRR_6 PF13516.1 ESA21088.1 - 1.4e-16 58.6 17.8 0.016 15.2 0.1 9.6 10 1 1 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.2 ESA21088.1 - 1.9e-16 59.2 5.8 7.7e-05 22.2 0.1 5.8 3 2 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA21088.1 - 3.6e-12 45.8 14.9 0.00023 20.8 0.7 5.4 3 2 1 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 ESA21088.1 - 3.5e-11 41.5 13.9 0.66 10.2 0.1 8.8 9 1 0 9 9 9 3 Leucine Rich Repeat LRR_7 PF13504.1 ESA21088.1 - 1.6e-09 36.3 12.5 0.97 9.9 0.0 8.6 9 0 0 9 9 9 3 Leucine rich repeat CDT1 PF08839.6 ESA21088.1 - 0.18 11.7 0.4 3.6 7.4 0.2 2.4 1 1 0 1 1 1 0 DNA replication factor CDT1 like zf-3CxxC PF13695.1 ESA21090.1 - 1.1e-07 31.9 9.6 4.3e-07 30.0 6.7 1.8 1 1 0 1 1 1 1 Zinc-binding domain Gti1_Pac2 PF09729.4 ESA21090.1 - 0.024 14.4 0.1 0.029 14.2 0.0 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Wbp11 PF09429.5 ESA21090.1 - 0.046 13.7 0.1 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 WW domain binding protein 11 zf-nanos PF05741.8 ESA21090.1 - 0.3 11.0 4.3 0.8 9.7 0.1 2.5 3 0 0 3 3 3 0 Nanos RNA binding domain CoiA PF06054.6 ESA21092.1 - 0.055 12.3 1.6 0.072 11.9 1.1 1.1 1 0 0 1 1 1 0 Competence protein CoiA-like family Viral_coat PF00729.13 ESA21094.1 - 0.069 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral coat protein (S domain) TLD PF07534.11 ESA21096.1 - 5.1e-12 45.9 1.3 1.2e-11 44.7 0.9 1.6 1 0 0 1 1 1 1 TLD NCD2 PF04905.8 ESA21097.1 - 0.0023 17.7 1.9 0.0036 17.1 1.3 1.3 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) DUF968 PF06147.6 ESA21097.1 - 0.016 15.1 0.5 0.019 14.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF968) ClpB_D2-small PF10431.4 ESA21097.1 - 0.14 12.1 2.4 0.28 11.0 0.2 2.1 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Rpp20 PF12328.3 ESA21097.1 - 0.17 11.5 4.0 0.28 10.8 2.8 1.3 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P ArfGap PF01412.13 ESA21098.1 - 1.7e-37 127.7 0.1 2e-37 127.5 0.1 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf HypA PF01155.14 ESA21098.1 - 0.07 12.8 0.1 0.093 12.4 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family OrfB_Zn_ribbon PF07282.6 ESA21098.1 - 0.13 11.9 0.2 0.19 11.4 0.2 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain G-patch PF01585.18 ESA21099.1 - 0.0027 17.4 0.5 0.034 13.9 0.4 2.4 1 1 0 1 1 1 1 G-patch domain DUF2217 PF10265.4 ESA21099.1 - 0.19 10.4 11.3 0.32 9.6 7.9 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) UPF0449 PF15136.1 ESA21099.1 - 0.88 9.8 8.1 0.47 10.6 1.3 2.8 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DUF3218 PF11508.3 ESA21100.1 - 0.057 12.9 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3218) TaqI_C PF12950.2 ESA21103.1 - 0.14 11.9 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain BTB PF00651.26 ESA21104.1 - 8.1e-15 54.7 0.2 4.2e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA21104.1 - 8.6e-08 32.2 0.1 2.7e-07 30.6 0.0 1.9 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA21104.1 - 3.4e-07 30.0 1.0 3.3e-06 26.8 0.1 2.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch PX PF00787.19 ESA21104.1 - 0.057 13.2 0.1 0.12 12.1 0.1 1.6 1 0 0 1 1 1 0 PX domain DUF2552 PF10827.3 ESA21105.1 - 0.19 11.6 0.6 0.33 10.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2552) DUF948 PF06103.6 ESA21105.1 - 0.24 11.2 1.1 16 5.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HeLo PF14479.1 ESA21105.1 - 0.58 9.8 2.9 0.95 9.1 0.0 2.3 1 1 1 2 2 2 0 Prion-inhibition and propagation zf-rbx1 PF12678.2 ESA21106.1 - 9.4e-36 121.7 13.7 1.1e-35 121.5 9.5 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 ESA21106.1 - 1.5e-17 63.1 9.9 2e-17 62.8 6.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 ESA21106.1 - 1.7e-07 30.9 12.2 1.1e-06 28.3 8.5 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 ESA21106.1 - 0.0012 18.4 12.1 0.022 14.3 8.4 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA21106.1 - 0.0017 18.0 9.7 0.2 11.3 6.9 2.3 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA21106.1 - 0.038 14.0 13.1 0.038 14.0 5.7 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 ESA21106.1 - 0.34 10.8 9.2 1.9 8.5 6.5 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_5 PF14634.1 ESA21106.1 - 0.62 9.8 12.0 6.3 6.6 8.3 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 ESA21106.1 - 0.63 9.8 6.8 0.76 9.5 1.5 2.2 1 1 1 2 2 2 0 RING-type zinc-finger zf-HC5HC2H PF13771.1 ESA21106.1 - 1.1 9.4 10.6 81 3.4 7.4 2.2 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 ESA21106.1 - 1.7 8.6 10.5 4.9 7.1 7.2 1.8 1 1 0 1 1 1 0 PHD-zinc-finger like domain Polysacc_deac_1 PF01522.16 ESA21107.1 - 7.5e-34 116.0 0.0 1.2e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 ESA21107.1 - 0.008 15.1 0.2 0.039 12.8 0.0 1.9 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 DEC-1_N PF04625.8 ESA21107.1 - 2 7.0 8.1 3.2 6.3 5.6 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region GST_C PF00043.20 ESA21108.1 - 2.6e-15 56.1 0.0 3.7e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 ESA21108.1 - 2.3e-10 40.5 0.0 4.5e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA21108.1 - 1.8e-09 37.4 0.0 3.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA21108.1 - 2.5e-09 36.9 0.0 4.5e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA21108.1 - 8.6e-09 35.4 0.1 5.6e-08 32.8 0.0 2.5 4 1 0 4 4 4 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 ESA21108.1 - 6.2e-07 29.8 0.0 9e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Prophage_tail PF06605.6 ESA21108.1 - 0.036 12.9 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 Prophage endopeptidase tail MIP-T3 PF10243.4 ESA21110.1 - 0.37 9.2 17.0 0.42 9.0 11.8 1.0 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Atrophin-1 PF03154.10 ESA21110.1 - 1 7.3 7.6 1.3 7.0 5.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family TEX19 PF15553.1 ESA21110.1 - 1.1 9.0 4.0 1 9.2 2.2 1.3 1 1 0 1 1 1 0 Testis-expressed protein 19 DUF2956 PF11169.3 ESA21110.1 - 4.3 7.3 10.9 8.7 6.3 7.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2956) RRM_1 PF00076.17 ESA21112.1 - 1.4e-46 155.9 0.1 9.9e-24 82.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA21112.1 - 1.6e-32 111.2 0.1 4.3e-18 65.0 0.0 3.8 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA21112.1 - 7.2e-27 93.0 0.0 8e-10 38.4 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 ESA21112.1 - 2e-21 76.0 0.1 4.7e-21 74.8 0.1 1.6 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_3 PF08777.6 ESA21112.1 - 1.5e-05 24.7 0.0 0.0019 18.0 0.0 2.9 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.1 ESA21112.1 - 9.2e-05 22.1 0.0 0.62 9.8 0.0 3.4 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif ELF PF03317.8 ESA21114.1 - 0.9 8.7 4.0 1.3 8.2 2.8 1.2 1 0 0 1 1 1 0 ELF protein DUF1700 PF08006.6 ESA21114.1 - 2.9 7.1 8.9 5 6.3 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF3677 PF12432.3 ESA21115.1 - 0.11 13.0 0.1 0.15 12.4 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3677) DUF4218 PF13960.1 ESA21116.1 - 0.011 15.2 0.2 0.016 14.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) F-box-like PF12937.2 ESA21118.1 - 3.3e-07 29.9 0.1 5.7e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 F-box-like DUF410 PF04190.8 ESA21118.1 - 0.088 12.3 0.8 0.12 11.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF410) TLD PF07534.11 ESA21119.1 - 1.2e-07 31.8 0.2 2.1e-07 31.0 0.0 1.4 1 1 0 1 1 1 1 TLD Pentapeptide_4 PF13599.1 ESA21119.1 - 0.043 13.6 0.1 0.053 13.3 0.1 1.2 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) F-box-like PF12937.2 ESA21120.1 - 3.4e-05 23.4 1.5 8.8e-05 22.1 1.1 1.7 1 0 0 1 1 1 1 F-box-like LRR19-TM PF15176.1 ESA21120.1 - 0.25 11.0 2.9 0.62 9.7 2.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain HrpB7 PF09486.5 ESA21121.1 - 3.9 7.3 25.2 19 5.1 0.1 4.7 2 2 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) Hydrolase_6 PF13344.1 ESA21121.1 - 4.5 7.2 15.9 1.8 8.4 0.7 4.0 2 1 1 4 4 4 0 Haloacid dehalogenase-like hydrolase Reo_sigmaC PF04582.7 ESA21121.1 - 4.7 6.3 23.9 3.6 6.6 1.2 3.4 1 1 1 3 3 3 0 Reovirus sigma C capsid protein LAGLIDADG_1 PF00961.14 ESA21123.1 - 0.73 10.4 3.9 1 9.9 2.7 1.3 1 1 0 1 1 1 0 LAGLIDADG endonuclease MPP6 PF10175.4 ESA21125.1 - 4.5e-06 26.9 1.5 6e-06 26.5 0.1 1.9 1 1 1 2 2 2 1 M-phase phosphoprotein 6 DUF4484 PF14831.1 ESA21126.1 - 0.72 9.9 2.8 0.8 9.7 1.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF659 PF04937.10 ESA21127.1 - 0.025 14.0 0.1 0.061 12.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Sed5p PF11416.3 ESA21127.1 - 0.057 12.8 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Integral membrane protein Sed5p zf-BED PF02892.10 ESA21128.1 - 0.00017 21.2 3.2 0.00061 19.5 2.2 2.0 1 0 0 1 1 1 1 BED zinc finger GatB_N PF02934.10 ESA21128.1 - 0.024 13.5 0.2 0.029 13.2 0.2 1.1 1 0 0 1 1 1 0 GatB/GatE catalytic domain zf-C4_ClpX PF06689.8 ESA21128.1 - 0.12 11.8 0.3 0.26 10.8 0.2 1.6 1 0 0 1 1 1 0 ClpX C4-type zinc finger LRR_8 PF13855.1 ESA21130.1 - 0.26 11.0 33.0 0.15 11.8 5.8 4.0 2 1 2 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 ESA21130.1 - 3.9 7.1 46.2 0.056 13.0 6.7 6.2 3 1 3 7 7 7 0 Leucine Rich repeats (2 copies) zf-CCHC_3 PF13917.1 ESA21131.1 - 0.025 14.3 0.1 0.037 13.7 0.1 1.3 1 0 0 1 1 1 0 Zinc knuckle Prp18 PF02840.10 ESA21133.1 - 0.00023 20.9 0.1 0.65 9.8 0.0 2.3 2 0 0 2 2 2 2 Prp18 domain Glyco_hydro_11 PF00457.12 ESA21133.1 - 0.013 14.8 5.8 0.43 9.9 0.2 2.7 1 1 2 3 3 3 0 Glycosyl hydrolases family 11 BCS1_N PF08740.6 ESA21133.1 - 0.013 15.0 0.1 3.7 7.1 0.0 2.3 2 0 0 2 2 2 0 BCS1 N terminal DUF2441 PF10386.4 ESA21133.1 - 0.042 13.8 2.0 0.097 12.6 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2441) SpoU_methylas_C PF12105.3 ESA21133.1 - 0.053 13.0 0.1 24 4.5 0.0 3.1 3 0 0 3 3 3 0 SpoU, rRNA methylase, C-terminal DUF4413 PF14372.1 ESA21133.1 - 0.059 13.3 1.4 0.62 10.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4413) PA14_2 PF10528.4 ESA21133.1 - 0.097 12.6 7.1 1.6 8.7 0.1 4.0 3 2 2 5 5 5 0 GLEYA domain DUF190 PF02641.10 ESA21133.1 - 0.097 12.5 0.4 97 2.9 0.0 4.0 3 1 1 4 4 4 0 Uncharacterized ACR, COG1993 DUF3991 PF13154.1 ESA21133.1 - 0.2 11.8 5.2 4.6 7.4 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3991) DUF2789 PF10982.3 ESA21133.1 - 1.3 9.1 4.4 1.2e+02 2.7 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2789) Dimer_Tnp_hAT PF05699.9 ESA21134.1 - 1.5e-18 66.2 0.0 1.6e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF3287 PF11690.3 ESA21135.1 - 0.0028 17.7 3.1 0.0028 17.7 2.2 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3287) ATG16 PF08614.6 ESA21135.1 - 0.0039 17.0 4.5 0.0055 16.5 3.1 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) IncA PF04156.9 ESA21135.1 - 0.005 16.4 5.7 0.0051 16.4 4.0 1.0 1 0 0 1 1 1 1 IncA protein NPV_P10 PF05531.7 ESA21135.1 - 0.0064 16.7 0.5 0.012 15.8 0.3 1.5 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.3 ESA21135.1 - 0.011 15.5 2.9 0.011 15.5 2.0 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FlxA PF14282.1 ESA21135.1 - 0.019 14.8 1.6 0.037 13.9 1.1 1.8 1 1 0 1 1 1 0 FlxA-like protein AAA_13 PF13166.1 ESA21135.1 - 0.019 13.4 5.2 0.021 13.2 3.6 1.0 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.9 ESA21135.1 - 0.025 14.2 6.8 0.028 14.0 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HR1 PF02185.11 ESA21135.1 - 0.03 14.0 6.3 1.3 8.8 0.8 2.2 1 1 1 2 2 2 0 Hr1 repeat BicD PF09730.4 ESA21135.1 - 0.042 12.2 5.4 0.046 12.0 3.8 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D Laminin_I PF06008.9 ESA21135.1 - 0.049 12.9 4.1 0.052 12.8 2.8 1.1 1 0 0 1 1 1 0 Laminin Domain I PilJ PF13675.1 ESA21135.1 - 0.055 13.7 2.9 0.064 13.5 2.0 1.1 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Med4 PF10018.4 ESA21135.1 - 0.063 12.6 2.8 0.065 12.6 1.6 1.3 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 GAS PF13851.1 ESA21135.1 - 0.066 12.3 6.9 0.076 12.1 4.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding RNA_pol_L_2 PF13656.1 ESA21135.1 - 0.071 12.5 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain CENP-Q PF13094.1 ESA21135.1 - 0.075 13.0 6.2 0.083 12.9 4.0 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit CorA PF01544.13 ESA21135.1 - 0.076 12.0 2.0 0.098 11.6 1.4 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein M PF02370.11 ESA21135.1 - 0.084 13.2 1.2 0.084 13.2 0.8 2.3 2 0 0 2 2 2 0 M protein repeat Tropomyosin_1 PF12718.2 ESA21135.1 - 0.091 12.6 6.8 0.11 12.3 4.7 1.2 1 0 0 1 1 1 0 Tropomyosin like Gp58 PF07902.6 ESA21135.1 - 0.093 10.9 0.6 0.097 10.8 0.4 1.1 1 0 0 1 1 1 0 gp58-like protein Prominin PF05478.6 ESA21135.1 - 0.093 10.2 1.0 0.1 10.1 0.7 1.0 1 0 0 1 1 1 0 Prominin DUF904 PF06005.7 ESA21135.1 - 0.093 13.0 4.0 0.16 12.2 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF745 PF05335.8 ESA21135.1 - 0.1 12.0 1.9 0.12 11.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) TMF_TATA_bd PF12325.3 ESA21135.1 - 0.12 12.1 5.8 0.083 12.6 1.9 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ACCA PF03255.9 ESA21135.1 - 0.12 11.8 3.3 0.15 11.5 0.7 1.8 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF3892 PF13031.1 ESA21135.1 - 0.14 12.5 1.4 0.18 12.2 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3892) Tweety PF04906.8 ESA21135.1 - 0.15 10.4 0.1 0.18 10.2 0.1 1.1 1 0 0 1 1 1 0 Tweety ADIP PF11559.3 ESA21135.1 - 0.16 11.8 7.5 0.051 13.4 2.8 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding APG6 PF04111.7 ESA21135.1 - 0.17 10.8 5.6 0.18 10.8 3.9 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 BRE1 PF08647.6 ESA21135.1 - 0.18 11.8 4.1 0.096 12.6 1.2 1.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Spc7 PF08317.6 ESA21135.1 - 0.18 10.4 4.1 0.2 10.2 2.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.7 ESA21135.1 - 0.19 11.5 2.5 0.23 11.2 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) COG2 PF06148.6 ESA21135.1 - 0.19 11.6 3.6 0.34 10.7 2.5 1.4 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 FliD_C PF07195.7 ESA21135.1 - 0.19 10.9 1.4 0.21 10.8 1.0 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Vps5 PF09325.5 ESA21135.1 - 0.21 10.8 6.1 0.24 10.6 4.2 1.2 1 0 0 1 1 1 0 Vps5 C terminal like V-ATPase_G PF03179.10 ESA21135.1 - 0.21 11.8 6.3 0.28 11.4 4.4 1.3 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Spc24 PF08286.6 ESA21135.1 - 0.24 11.0 2.8 0.48 10.1 1.8 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF2802 PF10975.3 ESA21135.1 - 0.25 11.1 2.6 2.2 8.1 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2802) IFT57 PF10498.4 ESA21135.1 - 0.27 9.9 4.6 0.26 9.9 3.2 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 FadA PF09403.5 ESA21135.1 - 0.27 11.2 5.6 0.33 10.9 3.9 1.1 1 0 0 1 1 1 0 Adhesion protein FadA Noelin-1 PF12308.3 ESA21135.1 - 0.3 10.8 2.4 0.34 10.7 1.6 1.2 1 0 0 1 1 1 0 Neurogenesis glycoprotein Syntaxin-6_N PF09177.6 ESA21135.1 - 0.35 11.2 3.4 0.48 10.8 2.4 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal HemX PF04375.9 ESA21135.1 - 0.38 9.3 3.5 0.4 9.2 2.4 1.0 1 0 0 1 1 1 0 HemX Fmp27_WPPW PF10359.4 ESA21135.1 - 0.38 9.1 4.8 0.39 9.0 3.3 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain RmuC PF02646.11 ESA21135.1 - 0.41 9.4 4.2 0.44 9.3 2.9 1.0 1 0 0 1 1 1 0 RmuC family Fib_alpha PF08702.5 ESA21135.1 - 0.48 10.5 3.3 0.67 10.0 2.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Herpes_UL6 PF01763.11 ESA21135.1 - 0.63 8.1 3.6 0.64 8.1 2.5 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like Mnd1 PF03962.10 ESA21135.1 - 0.8 9.3 6.6 0.94 9.1 4.6 1.1 1 0 0 1 1 1 0 Mnd1 family CCDC-167 PF15188.1 ESA21135.1 - 1 9.3 4.8 13 5.8 3.3 2.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 OmpH PF03938.9 ESA21135.1 - 1.1 9.2 4.9 1.3 8.9 3.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PEARLI-4 PF05278.7 ESA21135.1 - 1.1 8.5 7.8 1.3 8.3 5.4 1.0 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Striatin PF08232.7 ESA21135.1 - 3.2 8.0 9.2 3 8.1 4.3 2.0 1 1 1 2 2 2 0 Striatin family DUF4140 PF13600.1 ESA21135.1 - 5.2 7.5 8.2 1e+02 3.4 5.7 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Macoilin PF09726.4 ESA21135.1 - 6.9 4.8 8.0 8 4.6 5.6 1.0 1 0 0 1 1 1 0 Transmembrane protein IBR PF01485.16 ESA21136.1 - 1.7e-18 66.2 19.6 1.2e-11 44.2 1.5 4.7 3 2 2 5 5 5 2 IBR domain Potassium_chann PF11404.3 ESA21136.1 - 0.04 13.7 0.6 0.33 10.7 0.0 2.7 2 0 0 2 2 2 0 Potassium voltage-gated channel zinc_ribbon_2 PF13240.1 ESA21136.1 - 3.7 7.1 8.5 3.3 7.3 0.1 3.7 3 0 0 3 3 3 0 zinc-ribbon domain zf-RING_5 PF14634.1 ESA21136.1 - 8.3 6.2 37.6 0.44 10.3 7.6 3.5 3 0 0 3 3 3 0 zinc-RING finger domain Elongin_A PF06881.6 ESA21138.1 - 9.6e-17 61.3 0.5 2e-16 60.3 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box-like_2 PF13013.1 ESA21138.1 - 0.038 13.7 0.1 0.089 12.5 0.1 1.6 1 0 0 1 1 1 0 F-box-like domain DNA_binding_2 PF13724.1 ESA21139.1 - 1.4 9.0 5.4 0.56 10.3 0.2 2.1 2 0 0 2 2 2 0 DNA-binding domain Histone PF00125.19 ESA21140.1 - 1.1e-14 54.3 0.1 1.3e-14 54.0 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA21140.1 - 2.7e-05 24.2 0.0 3.5e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 ESA21140.1 - 7.2e-05 22.6 0.1 0.0001 22.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 ESA21140.1 - 0.00031 20.7 0.1 0.00063 19.7 0.0 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 ESA21140.1 - 0.023 13.9 0.0 0.023 13.9 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 ESA21140.1 - 0.036 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.8 ESA21140.1 - 0.14 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A ubiquitin PF00240.18 ESA21142.1 - 3.1e-127 414.1 22.9 3.7e-34 115.9 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.3 ESA21142.1 - 6.1e-71 234.0 19.9 3.2e-19 68.3 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 ESA21142.1 - 2.5e-24 85.3 11.2 5.7e-05 23.2 0.1 5.8 3 3 1 4 4 4 4 Ubiquitin-like domain Telomere_Sde2 PF13019.1 ESA21142.1 - 1.5e-15 57.2 1.0 0.00092 18.9 0.0 4.0 3 1 1 4 4 4 3 Telomere stability and silencing DUF2407 PF10302.4 ESA21142.1 - 2e-14 53.5 1.7 0.073 13.2 0.0 4.1 1 1 3 4 4 4 4 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 ESA21142.1 - 5.8e-14 51.9 2.1 0.097 12.5 0.0 4.9 3 3 1 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2870 PF11069.3 ESA21142.1 - 2e-10 40.5 0.0 1.3 9.0 0.0 4.9 3 1 1 4 4 4 4 Protein of unknown function (DUF2870) TUG-UBL1 PF11470.3 ESA21142.1 - 2.7e-08 33.5 2.7 0.66 9.9 0.0 4.2 3 1 1 4 4 4 3 GLUT4 regulating protein TUG Plexin_cytopl PF08337.7 ESA21142.1 - 4.5e-05 21.9 12.7 0.28 9.4 0.3 5.3 5 2 0 5 5 5 3 Plexin cytoplasmic RasGAP domain DUF3221 PF11518.3 ESA21142.1 - 8.2e-05 22.2 1.9 5.2 6.7 0.0 3.8 3 1 1 4 4 4 2 Protein of unknown function (DUF3221) USP7_C2 PF14533.1 ESA21142.1 - 0.001 18.5 4.0 2.8 7.3 0.2 3.5 1 1 1 3 3 3 1 Ubiquitin-specific protease C-terminal FlgD_ig PF13860.1 ESA21142.1 - 0.0015 18.2 5.5 7 6.4 0.0 4.2 4 0 0 4 4 4 0 FlgD Ig-like domain Methyltrans_RNA PF04452.9 ESA21142.1 - 0.0027 16.8 0.2 1.2 8.1 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase RA PF00788.18 ESA21142.1 - 0.01 16.3 0.1 65 4.1 0.0 3.8 4 0 0 4 4 4 0 Ras association (RalGDS/AF-6) domain ANTAR PF03861.9 ESA21142.1 - 0.012 15.2 0.0 57 3.4 0.0 3.9 4 0 0 4 4 4 0 ANTAR domain ACT_4 PF13291.1 ESA21142.1 - 0.039 14.3 0.3 53 4.2 0.0 3.3 3 0 0 3 3 3 0 ACT domain WTF PF03303.8 ESA21142.1 - 0.041 13.2 0.4 0.57 9.5 0.0 2.8 4 0 0 4 4 4 0 WTF protein Ubiquitin_3 PF14836.1 ESA21142.1 - 0.052 13.2 3.4 13 5.5 0.0 4.2 3 1 0 4 4 4 0 Ubiquitin-like domain EMG1 PF03587.9 ESA21142.1 - 0.086 12.1 0.8 16 4.7 0.0 2.9 3 0 0 3 3 3 0 EMG1/NEP1 methyltransferase Tash_PEST PF07708.6 ESA21142.1 - 0.2 11.6 19.9 3.2 7.8 1.2 3.5 3 0 0 3 3 3 0 Tash protein PEST motif FERM_N PF09379.5 ESA21142.1 - 0.22 11.5 10.7 17 5.5 0.3 4.8 3 3 0 3 3 3 0 FERM N-terminal domain CDC48_2 PF02933.12 ESA21142.1 - 0.33 10.6 9.8 9.2 5.9 0.3 3.3 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 DUF262 PF03235.9 ESA21143.1 - 0.16 11.9 2.8 0.19 11.6 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4258 PF14076.1 ESA21143.1 - 0.22 11.5 3.8 36 4.4 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4258) LRR_8 PF13855.1 ESA21144.1 - 3.4e-05 23.5 4.2 0.00019 21.1 2.9 2.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 ESA21144.1 - 0.0011 18.5 6.0 0.0011 18.5 4.1 3.7 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) GATase_7 PF13537.1 ESA21144.1 - 0.53 10.0 3.4 6.2 6.5 0.7 2.8 1 1 2 3 3 3 0 Glutamine amidotransferase domain LRR_7 PF13504.1 ESA21144.1 - 1.9 9.0 6.1 20 5.9 0.2 4.5 3 1 1 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 ESA21144.1 - 7.7 6.9 12.5 4.4 7.7 1.0 4.5 3 1 1 4 4 4 0 Leucine Rich Repeat p450 PF00067.17 ESA21146.1 - 6.5e-14 51.3 1.0 7.2e-14 51.1 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 JmjN PF02375.12 ESA21147.1 - 0.29 10.6 0.1 0.29 10.6 0.0 1.6 2 0 0 2 2 2 0 jmjN domain DUF2935 PF11155.3 ESA21148.1 - 0.0088 16.1 6.0 0.0088 16.1 4.2 3.4 2 2 1 3 3 3 1 Domain of unknown function (DUF2935) MCPsignal PF00015.16 ESA21148.1 - 0.14 11.6 18.2 0.65 9.5 1.1 3.1 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Seryl_tRNA_N PF02403.17 ESA21148.1 - 0.28 11.2 39.3 0.21 11.6 5.1 4.0 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Baculo_PEP_C PF04513.7 ESA21148.1 - 0.64 9.8 13.3 0.13 12.0 0.9 3.7 3 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus AATF-Che1 PF13339.1 ESA21148.1 - 2.1 8.4 23.1 2.5 8.2 4.2 3.5 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF1664 PF07889.7 ESA21148.1 - 2.5 7.8 29.1 0.93 9.2 3.3 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) UPF0184 PF03670.8 ESA21148.1 - 2.8 8.1 16.3 0.6 10.3 1.0 3.6 3 2 1 4 4 4 0 Uncharacterised protein family (UPF0184) CENP-F_leu_zip PF10473.4 ESA21148.1 - 8.6 6.2 40.4 0.18 11.6 3.8 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA PF00004.24 ESA21149.1 - 2.9e-38 131.0 0.0 4.6e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA21149.1 - 5.3e-07 29.8 0.1 7.3e-05 22.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 ESA21149.1 - 6.5e-07 29.1 0.0 5.3e-06 26.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 ESA21149.1 - 4.6e-06 26.7 0.2 0.00056 19.9 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 ESA21149.1 - 6.1e-06 26.1 0.0 1.7e-05 24.7 0.0 1.7 1 1 1 2 2 1 1 AAA domain AAA_33 PF13671.1 ESA21149.1 - 1.1e-05 25.2 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA21149.1 - 1.7e-05 25.6 0.0 4.6e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESA21149.1 - 3.4e-05 23.0 0.0 0.00013 21.0 0.0 1.9 1 1 1 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 ESA21149.1 - 0.00011 22.1 0.0 0.00023 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 ESA21149.1 - 0.00014 22.1 0.4 0.0024 18.2 0.0 2.6 3 0 0 3 3 2 1 AAA domain Bac_DnaA PF00308.13 ESA21149.1 - 0.00029 20.5 0.0 0.00066 19.3 0.0 1.5 1 1 0 1 1 1 1 Bacterial dnaA protein Mg_chelatase PF01078.16 ESA21149.1 - 0.0011 18.2 0.6 0.0025 17.0 0.2 1.7 2 1 0 2 2 1 1 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 ESA21149.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NACHT PF05729.7 ESA21149.1 - 0.0013 18.4 0.4 0.0041 16.8 0.1 2.0 3 0 0 3 3 2 1 NACHT domain IstB_IS21 PF01695.12 ESA21149.1 - 0.0015 18.0 0.1 0.0028 17.0 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 ESA21149.1 - 0.0017 17.8 0.5 0.12 11.7 0.1 2.2 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA21149.1 - 0.0022 18.1 0.0 0.0051 16.9 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_28 PF13521.1 ESA21149.1 - 0.0025 17.7 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 ESA21149.1 - 0.0067 15.5 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin TIP49 PF06068.8 ESA21149.1 - 0.0071 15.1 0.1 0.018 13.8 0.0 1.7 1 1 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 ESA21149.1 - 0.0092 15.7 0.2 0.021 14.5 0.2 1.5 1 0 0 1 1 1 1 Part of AAA domain Sigma54_activ_2 PF14532.1 ESA21149.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.22 ESA21149.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Oxidored_nitro PF00148.14 ESA21149.1 - 0.023 13.3 0.0 0.042 12.4 0.0 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Rad17 PF03215.10 ESA21149.1 - 0.023 13.3 0.0 0.036 12.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Guanylate_kin PF00625.16 ESA21149.1 - 0.025 14.0 0.0 0.29 10.5 0.0 2.6 2 1 0 3 3 3 0 Guanylate kinase SKI PF01202.17 ESA21149.1 - 0.028 14.2 0.1 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase DUF815 PF05673.8 ESA21149.1 - 0.031 13.1 0.0 0.052 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CPT PF07931.7 ESA21149.1 - 0.035 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_10 PF12846.2 ESA21149.1 - 0.036 13.5 0.6 4.2 6.7 0.1 2.6 2 1 0 2 2 2 0 AAA-like domain Sigma54_activat PF00158.21 ESA21149.1 - 0.053 13.0 0.0 0.13 11.7 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.6 ESA21149.1 - 0.056 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UPF0079 PF02367.12 ESA21149.1 - 0.069 12.7 0.1 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NB-ARC PF00931.17 ESA21149.1 - 0.07 11.9 0.1 0.17 10.7 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Cas_Csx8 PF09657.5 ESA21149.1 - 0.086 11.5 0.3 0.15 10.7 0.2 1.3 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) KaiC PF06745.8 ESA21149.1 - 0.095 11.8 0.0 0.51 9.4 0.0 2.0 1 1 1 2 2 2 0 KaiC RNase_PH PF01138.16 ESA21150.1 - 2e-27 96.1 0.0 2.9e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Peptidase_S9 PF00326.16 ESA21151.1 - 8.1e-56 188.6 0.0 9.8e-56 188.3 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 ESA21151.1 - 0.00048 20.0 0.0 0.00077 19.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.13 ESA21151.1 - 0.0029 17.0 0.0 0.015 14.7 0.0 1.8 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESA21151.1 - 0.013 15.0 0.0 0.044 13.3 0.0 1.7 1 1 1 2 2 2 0 alpha/beta hydrolase fold VWA_2 PF13519.1 ESA21152.1 - 0.0011 19.0 0.0 0.0012 18.9 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain NUMOD1 PF07453.8 ESA21152.1 - 0.039 13.7 0.1 9.4 6.2 0.0 2.3 2 0 0 2 2 2 0 NUMOD1 domain VWA_CoxE PF05762.9 ESA21152.1 - 0.061 12.4 0.0 0.066 12.3 0.0 1.1 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein VWA PF00092.23 ESA21152.1 - 0.064 12.9 0.0 0.068 12.8 0.0 1.1 1 0 0 1 1 1 0 von Willebrand factor type A domain Mt_ATP-synt_D PF05873.7 ESA21153.1 - 0.077 12.6 1.6 0.076 12.6 0.4 1.7 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Sel1 PF08238.7 ESA21155.1 - 4.7e-40 135.1 5.6 2.1e-10 40.8 0.0 4.0 4 0 0 4 4 4 4 Sel1 repeat AdoMet_MTase PF07757.8 ESA21155.1 - 0.00017 21.6 2.4 3.5 7.7 0.0 3.1 1 1 2 3 3 3 3 Predicted AdoMet-dependent methyltransferase MIT PF04212.13 ESA21155.1 - 0.0036 17.1 13.3 0.46 10.3 1.5 3.7 2 2 2 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA21155.1 - 0.0056 16.3 10.8 0.065 12.8 0.9 3.2 1 1 2 3 3 3 3 TPR repeat TFIIB PF00382.14 ESA21155.1 - 0.022 14.5 0.3 35 4.2 0.0 3.7 3 1 1 4 4 4 0 Transcription factor TFIIB repeat SNAP PF14938.1 ESA21155.1 - 0.051 12.7 4.9 2.6 7.1 0.2 3.5 2 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESA21155.1 - 0.47 10.4 12.5 30 4.6 0.9 4.2 1 1 2 3 3 3 0 Tetratricopeptide repeat NSF PF02071.15 ESA21155.1 - 0.49 11.1 9.9 1.7e+02 3.5 0.0 5.1 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat ATP-synt_DE PF00401.15 ESA21155.1 - 3 7.8 6.7 56 3.7 0.0 3.1 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DBB PF14545.1 ESA21156.1 - 0.001 18.5 0.2 0.001 18.5 0.1 1.0 1 0 0 1 1 1 1 Dof, BCAP, and BANK (DBB) motif, DUF1347 PF07079.6 ESA21157.1 - 0.03 12.5 0.1 0.034 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) Pkinase PF00069.20 ESA21159.1 - 4.2e-29 101.4 0.1 2.1e-27 95.9 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21159.1 - 9.5e-29 100.2 0.4 5.6e-27 94.4 0.2 2.8 2 1 0 2 2 2 1 Protein tyrosine kinase YfkD PF14167.1 ESA21160.1 - 0.13 11.2 0.1 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 YfkD-like protein FAM60A PF15396.1 ESA21163.1 - 0.017 14.9 0.1 0.019 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Cupredoxin_1 PF13473.1 ESA21165.1 - 0.012 15.5 0.3 0.02 14.7 0.2 1.5 1 0 0 1 1 1 0 Cupredoxin-like domain Dimer_Tnp_hAT PF05699.9 ESA21166.1 - 2.4e-06 27.0 0.1 2.6e-06 26.9 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Tet_JBP PF12851.2 ESA21167.1 - 7.1e-09 35.1 0.0 1.2e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily 2OG-FeII_Oxy_3 PF13640.1 ESA21167.1 - 0.033 14.6 0.0 0.054 14.0 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily p450 PF00067.17 ESA21168.1 - 5.2e-25 87.8 0.8 1e-24 86.9 0.6 1.4 1 1 0 1 1 1 1 Cytochrome P450 DUF3149 PF11346.3 ESA21168.1 - 9.5 5.8 7.5 0.66 9.5 0.9 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3149) Brevenin PF03032.10 ESA21170.1 - 4.1 7.3 6.8 8.2 6.3 4.7 1.5 1 1 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family E1-E2_ATPase PF00122.15 ESA21171.1 - 1.4e-61 207.5 2.0 1.4e-61 207.5 1.4 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA21171.1 - 1.2e-43 148.7 9.9 1.2e-43 148.7 6.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA21171.1 - 7.4e-26 91.8 0.0 2.4e-25 90.2 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 ESA21171.1 - 2.2e-20 72.4 0.0 5.8e-20 71.0 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESA21171.1 - 3.2e-13 50.2 0.0 7.1e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA21171.1 - 9e-11 41.0 0.0 2.4e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 ESA21171.1 - 6.2e-05 22.7 0.5 0.00021 20.9 0.3 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RNA_pol_Rpb5_C PF01191.14 ESA21172.1 - 1e-34 117.9 0.2 1e-34 117.9 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 ESA21172.1 - 1.5e-21 76.5 0.9 2.9e-21 75.6 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Pyr_excise PF03013.9 ESA21172.1 - 0.052 13.3 1.0 0.44 10.3 0.1 2.3 1 1 0 2 2 2 0 Pyrimidine dimer DNA glycosylase Mrr_cat PF04471.7 ESA21172.1 - 0.072 12.9 0.0 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Restriction endonuclease AAA_12 PF13087.1 ESA21173.1 - 5.8e-46 156.3 0.5 2.2e-45 154.4 0.4 2.1 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA21173.1 - 3.5e-40 138.0 0.8 9.7e-38 130.0 0.0 4.2 3 1 0 3 3 3 1 AAA domain SEN1_N PF12726.2 ESA21173.1 - 7.6e-37 126.7 24.7 1.3e-36 125.9 17.1 1.3 1 0 0 1 1 1 1 SEN1 N terminal Viral_helicase1 PF01443.13 ESA21173.1 - 8.8e-07 28.6 0.2 0.018 14.5 0.0 3.7 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 ESA21173.1 - 3.8e-06 26.5 0.0 7.7e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA21173.1 - 2.1e-05 24.1 0.0 0.00064 19.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 ESA21173.1 - 0.064 13.3 0.0 0.25 11.5 0.0 2.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.9 ESA21173.1 - 0.067 12.8 0.1 0.61 9.7 0.0 2.5 2 0 0 2 2 2 0 Helicase Pkinase PF00069.20 ESA21175.1 - 5.1e-85 284.7 2.0 3.2e-39 134.6 0.0 4.6 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21175.1 - 2.2e-47 161.2 0.0 2e-19 69.6 0.0 3.7 3 0 0 3 3 3 3 Protein tyrosine kinase HGTP_anticodon2 PF12745.2 ESA21175.1 - 2.1e-35 122.2 8.4 2.1e-35 122.2 5.8 2.6 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs RWD PF05773.17 ESA21175.1 - 6.6e-12 45.3 0.8 4.8e-11 42.5 0.0 2.6 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.1 ESA21175.1 - 3.1e-11 42.9 0.4 4.6e-10 39.0 0.0 2.7 2 1 0 2 2 2 1 Histidyl-tRNA synthetase Kinase-like PF14531.1 ESA21175.1 - 3e-08 32.9 0.0 0.0001 21.4 0.0 2.7 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 ESA21175.1 - 0.0019 18.0 0.0 0.012 15.3 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Mating_N PF12731.2 ESA21176.1 - 0.00027 20.7 5.7 1.1 9.1 0.1 3.3 1 1 3 4 4 4 3 Mating-type protein beta 1 DUF2294 PF10057.4 ESA21176.1 - 0.0019 17.8 0.2 2.7 7.6 0.0 3.3 1 1 3 4 4 4 1 Uncharacterized conserved protein (DUF2294) Flg_hook PF02120.11 ESA21176.1 - 0.0056 16.3 17.1 8.7 6.0 0.2 5.9 2 2 3 6 6 6 1 Flagellar hook-length control protein FliK DUF4125 PF13526.1 ESA21176.1 - 0.0062 16.0 10.3 0.42 10.0 2.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF4125) CagA PF03507.8 ESA21176.1 - 0.024 14.4 0.3 2.7 7.7 0.0 2.7 2 1 1 3 3 3 0 CagA exotoxin ApoLp-III PF07464.6 ESA21176.1 - 0.045 13.7 1.3 0.092 12.7 0.9 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Apolipoprotein PF01442.13 ESA21176.1 - 0.069 12.6 11.2 0.14 11.6 7.8 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Use1 PF09753.4 ESA21176.1 - 0.11 11.9 9.8 2 7.7 2.1 2.8 1 1 1 2 2 2 0 Membrane fusion protein Use1 B-block_TFIIIC PF04182.7 ESA21176.1 - 0.13 12.0 1.8 12 5.7 1.2 3.1 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC Strep_his_triad PF04270.8 ESA21176.1 - 0.29 10.8 8.4 0.6 9.8 0.3 3.6 1 1 2 4 4 4 0 Streptococcal histidine triad protein Hpt PF01627.18 ESA21176.1 - 0.53 10.3 3.8 16 5.5 0.1 2.8 2 1 0 2 2 2 0 Hpt domain Fib_alpha PF08702.5 ESA21176.1 - 0.66 10.0 12.7 0.17 11.9 2.1 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Glyco_hydro_32C PF08244.7 ESA21176.1 - 1.5 9.2 6.2 27 5.2 0.3 3.4 1 1 3 4 4 4 0 Glycosyl hydrolases family 32 C terminal Exonuc_VII_L PF02601.10 ESA21176.1 - 2.1 7.4 9.9 3 6.9 6.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit IcmL PF11393.3 ESA21176.1 - 6.8 6.6 11.3 9.5 6.2 1.3 3.2 2 1 2 4 4 4 0 Macrophage killing protein with similarity to conjugation protein Sel1 PF08238.7 ESA21177.1 - 5.3e-32 109.5 8.0 3e-12 46.7 0.6 3.1 3 0 0 3 3 3 3 Sel1 repeat TPR_7 PF13176.1 ESA21177.1 - 0.04 13.7 0.1 5.9 6.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21177.1 - 0.044 13.7 5.2 2.5 8.1 0.2 3.7 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA21177.1 - 0.051 13.2 9.3 3 7.5 3.3 3.1 1 1 1 3 3 3 0 TPR repeat MIT PF04212.13 ESA21177.1 - 1.1 9.2 9.4 2.6 7.9 1.3 3.3 1 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 ESA21177.1 - 2.2 8.1 7.5 3.3 7.6 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA21177.1 - 3.6 7.6 4.9 30 4.7 0.0 4.2 5 1 0 5 5 5 0 Tetratricopeptide repeat Steroid_dh PF02544.11 ESA21178.1 - 0.0093 15.7 0.2 0.011 15.5 0.1 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Sel1 PF08238.7 ESA21179.1 - 8.2e-57 188.4 7.8 6.3e-11 42.5 0.0 6.3 6 1 0 6 6 6 6 Sel1 repeat DUF2553 PF10830.3 ESA21179.1 - 0.048 14.1 1.6 1.6 9.3 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2553) Lipase3_N PF03893.11 ESA21179.1 - 0.15 11.8 0.1 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Lipase 3 N-terminal region SNAP PF14938.1 ESA21179.1 - 0.16 11.0 2.7 0.36 9.9 0.2 2.3 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP DUF3601 PF12208.3 ESA21179.1 - 0.17 11.8 1.1 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3601) TPR_11 PF13414.1 ESA21179.1 - 0.69 9.6 15.9 9 6.0 2.8 4.9 2 2 4 6 6 6 0 TPR repeat MIT PF04212.13 ESA21179.1 - 1.8 8.4 13.0 6.8 6.6 1.1 4.6 2 2 1 3 3 3 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA21180.1 - 2.3e-52 174.2 12.7 4.5e-09 36.6 0.0 6.0 6 0 0 6 6 6 6 Sel1 repeat MIT PF04212.13 ESA21180.1 - 1.2 9.0 5.5 1.7 8.5 0.6 3.2 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2812 PF11193.3 ESA21180.1 - 3.8 7.7 9.3 6 7.0 2.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2812) CotJB PF12652.2 ESA21180.1 - 4.3 7.4 6.4 35 4.5 0.6 3.5 3 1 1 4 4 4 0 CotJB protein Fijivirus_P9-2 PF06837.6 ESA21181.1 - 0.017 14.2 5.6 0.028 13.5 3.8 1.3 1 0 0 1 1 1 0 Fijivirus P9-2 protein Chal_sti_synt_C PF02797.10 ESA21181.1 - 0.03 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain Baculo_11_kDa PF06143.6 ESA21181.1 - 0.045 13.1 3.0 0.24 10.7 1.8 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF2244 PF10003.4 ESA21181.1 - 0.35 10.2 2.4 0.76 9.1 0.0 2.1 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) DUF3192 PF11399.3 ESA21182.1 - 0.14 12.1 2.3 4.6 7.2 0.1 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3192) GATA PF00320.22 ESA21183.1 - 1.6e-15 56.1 2.8 3.9e-15 54.9 1.9 1.7 1 0 0 1 1 1 1 GATA zinc finger E2F_TDP PF02319.15 ESA21183.1 - 0.04 13.4 0.0 0.08 12.5 0.0 1.5 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain F-box-like PF12937.2 ESA21184.1 - 0.00066 19.3 1.0 0.0026 17.4 0.7 2.1 1 0 0 1 1 1 1 F-box-like Sel1 PF08238.7 ESA21185.1 - 2e-13 50.4 7.3 0.00019 21.9 0.0 3.4 3 0 0 3 3 3 3 Sel1 repeat Pkinase_Tyr PF07714.12 ESA21185.1 - 1.7e-07 30.5 0.1 3.1e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21185.1 - 0.00082 18.5 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA21186.1 - 1.1e-36 126.3 0.0 1.9e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21186.1 - 1.1e-35 122.9 0.0 1.5e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase MIF4G PF02854.14 ESA21190.1 - 7e-30 104.0 0.9 7e-30 104.0 0.6 2.5 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.12 ESA21190.1 - 3.8e-26 90.9 0.9 9.7e-26 89.6 0.6 1.7 1 0 0 1 1 1 1 MA3 domain Cwf_Cwc_15 PF04889.7 ESA21190.1 - 4 7.0 23.3 5.7 6.5 7.4 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Vfa1 PF08432.5 ESA21190.1 - 8.1 6.4 12.4 3.3 7.7 3.0 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Peptidase_M24 PF00557.19 ESA21191.1 - 2.4e-44 151.3 0.0 2.9e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Trs65 PF12735.2 ESA21192.1 - 7.7e-06 25.4 0.1 7.7e-06 25.4 0.1 1.4 2 0 0 2 2 2 1 TRAPP trafficking subunit Trs65 Ribosomal_S4Pg PF11993.3 ESA21194.1 - 2.7e-05 24.0 0.1 20 4.8 0.0 4.0 4 0 0 4 4 4 0 Ribosomal S4P (gammaproteobacterial) DUF4646 PF15496.1 ESA21194.1 - 8.6e-05 22.5 0.0 17 5.4 0.0 4.4 4 2 1 5 5 5 0 Domain of unknown function (DUF4646) Phage_antiter_Q PF06323.6 ESA21194.1 - 0.0021 17.4 0.0 8.7 5.6 0.0 3.1 3 0 0 3 3 3 2 Phage antitermination protein Q BCNT PF07572.7 ESA21194.1 - 0.0042 16.9 1.0 80 3.2 0.0 4.1 4 0 0 4 4 4 0 Bucentaur or craniofacial development Mak16 PF04874.9 ESA21194.1 - 0.0051 16.8 1.7 24 5.1 0.2 3.4 3 0 0 3 3 3 0 Mak16 protein C-terminal region Bcl-2_3 PF15286.1 ESA21194.1 - 0.13 12.7 0.3 97 3.4 0.0 3.2 3 0 0 3 3 3 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like BpuJI_N PF11564.3 ESA21194.1 - 0.54 9.1 2.4 33 3.2 0.0 3.1 3 0 0 3 3 3 0 Restriction endonuclease BpuJI - N terminal SRP1_TIP1 PF00660.12 ESA21194.1 - 1.2 9.0 5.0 27 4.6 0.1 3.2 3 0 0 3 3 3 0 Seripauperin and TIP1 family RE_NgoBV PF09564.5 ESA21194.1 - 3.4 6.8 7.5 7.8 5.6 0.2 3.2 3 0 0 3 3 3 0 NgoBV restriction endonuclease Dimer_Tnp_hAT PF05699.9 ESA21196.1 - 1.4e-13 50.2 0.0 1.7e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region 4HB_MCP_1 PF12729.2 ESA21197.1 - 0.034 13.5 1.3 0.04 13.2 0.9 1.1 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Phe_tRNA-synt_N PF02912.13 ESA21197.1 - 0.077 12.7 0.4 0.1 12.3 0.3 1.2 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain HMG_box PF00505.14 ESA21198.1 - 0.068 13.4 0.2 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 HMG (high mobility group) box BTB PF00651.26 ESA21199.1 - 2e-16 59.9 0.2 4.9e-16 58.6 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21199.1 - 2.2e-16 60.1 2.7 2.2e-16 60.1 1.9 2.3 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA21199.1 - 0.00029 20.6 0.7 0.00029 20.6 0.5 2.5 2 1 2 4 4 4 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA21200.1 - 0.056 12.4 0.1 0.085 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase TLD PF07534.11 ESA21201.1 - 5.2e-12 45.9 3.2 8.7e-12 45.2 2.2 1.4 1 0 0 1 1 1 1 TLD SPRY PF00622.23 ESA21203.1 - 1.6e-12 47.6 0.6 2.8e-12 46.7 0.4 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA21203.1 - 2.7e-08 33.7 2.7 6.2e-08 32.6 0.5 2.2 2 0 0 2 2 2 1 BTB/POZ domain Transposase_21 PF02992.9 ESA21204.1 - 0.00042 19.4 0.4 0.061 12.4 0.0 2.2 1 1 1 2 2 2 2 Transposase family tnp2 Sel1 PF08238.7 ESA21205.1 - 4.7e-142 459.3 82.0 3.6e-13 49.6 1.6 12.2 12 0 0 12 12 12 12 Sel1 repeat TPR_6 PF13174.1 ESA21205.1 - 5.9e-18 64.0 39.3 0.027 14.9 0.2 10.9 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_17 PF13431.1 ESA21205.1 - 2e-09 36.9 47.6 0.44 10.8 0.4 12.5 12 0 0 12 12 11 5 Tetratricopeptide repeat Peptidase_C14 PF00656.17 ESA21205.1 - 2.5e-09 37.2 0.0 1.5 8.4 0.0 6.7 2 2 3 5 5 5 3 Caspase domain TPR_12 PF13424.1 ESA21205.1 - 4.3e-09 36.1 55.6 0.0038 17.1 1.7 9.4 2 2 8 10 10 10 8 Tetratricopeptide repeat MIT PF04212.13 ESA21205.1 - 1.5e-08 34.3 50.5 0.22 11.4 0.4 11.4 9 2 2 11 11 11 5 MIT (microtubule interacting and transport) domain TPR_16 PF13432.1 ESA21205.1 - 2.6e-08 34.3 14.8 0.11 13.2 0.0 8.3 3 3 8 11 11 10 2 Tetratricopeptide repeat TPR_20 PF14561.1 ESA21205.1 - 6.6e-07 29.3 5.3 2.6 8.2 0.0 6.4 3 3 4 7 7 7 2 Tetratricopeptide repeat IL22 PF14565.1 ESA21205.1 - 1.5e-05 25.0 1.7 8.2 6.5 0.0 6.4 1 1 6 9 9 9 1 Interleukin 22 IL-10-related T-cell-derived-inducible factor Apc3 PF12895.2 ESA21205.1 - 2.5e-05 24.3 59.5 0.45 10.6 0.2 9.0 5 3 4 9 9 9 6 Anaphase-promoting complex, cyclosome, subunit 3 Surfac_D-trimer PF09006.6 ESA21205.1 - 3.8e-05 23.3 11.2 76 3.1 0.0 10.0 12 0 0 12 12 12 0 Lung surfactant protein D coiled-coil trimerisation TPR_19 PF14559.1 ESA21205.1 - 0.00022 21.4 35.4 5.3 7.4 0.0 10.0 7 3 4 11 11 11 3 Tetratricopeptide repeat Ribosomal_L13 PF00572.13 ESA21205.1 - 0.0051 16.8 2.0 0.99 9.4 0.0 3.2 4 0 0 4 4 4 1 Ribosomal protein L13 Flu_M1_C PF08289.6 ESA21205.1 - 0.0061 16.5 0.0 25 4.9 0.0 5.2 3 3 2 6 6 6 0 Influenza Matrix protein (M1) C-terminal domain Phage_T4_gp19 PF06841.7 ESA21205.1 - 0.034 13.7 7.4 22 4.6 0.0 5.4 5 2 2 7 7 7 0 T4-like virus tail tube protein gp19 MFS_1 PF07690.11 ESA21207.1 - 1.2e-24 86.7 16.0 9.3e-24 83.7 6.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.8 ESA21207.1 - 0.49 8.4 9.7 0.14 10.1 0.9 2.6 3 0 0 3 3 3 0 Transmembrane secretion effector TolB_N PF04052.8 ESA21209.1 - 0.025 14.6 0.0 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 TolB amino-terminal domain DivIC PF04977.10 ESA21210.1 - 3.8 7.0 6.9 0.42 10.1 0.7 2.5 2 1 0 2 2 2 0 Septum formation initiator Uds1 PF15456.1 ESA21210.1 - 5.9 6.8 11.5 28 4.7 0.1 2.6 1 1 1 2 2 2 0 Up-regulated During Septation RNA_pol_L_2 PF13656.1 ESA21212.1 - 0.096 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain SPRY PF00622.23 ESA21213.1 - 2e-08 34.3 0.7 3.6e-08 33.5 0.5 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA21213.1 - 5.1e-06 26.4 3.6 2.6e-05 24.1 0.2 2.5 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.26 ESA21216.1 - 2.1e-17 63.0 0.3 2.4e-16 59.6 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA21216.1 - 4.9e-14 52.4 1.5 1.1e-13 51.3 1.0 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA21216.1 - 2e-05 24.3 3.2 3.8e-05 23.4 0.2 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch Zip PF02535.17 ESA21216.1 - 0.0055 15.7 3.9 0.0079 15.2 2.7 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Mem_trans PF03547.13 ESA21216.1 - 0.013 13.7 1.0 0.016 13.4 0.7 1.1 1 0 0 1 1 1 0 Membrane transport protein Band_3_cyto PF07565.8 ESA21216.1 - 0.18 11.2 5.5 0.37 10.2 3.8 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain FCP1_C PF09309.5 ESA21216.1 - 0.27 10.4 11.8 0.43 9.8 8.2 1.2 1 0 0 1 1 1 0 FCP1, C-terminal DUF4337 PF14235.1 ESA21216.1 - 1.2 8.9 10.9 2 8.2 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4175 PF13779.1 ESA21216.1 - 1.3 6.6 19.8 1.7 6.2 13.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Neur_chan_memb PF02932.11 ESA21216.1 - 1.7 8.4 5.5 3.2 7.5 3.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region BAF1_ABF1 PF04684.8 ESA21216.1 - 7.5 5.2 22.3 12 4.6 15.5 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor BTB PF00651.26 ESA21217.1 - 3.8e-22 78.3 1.1 8.6e-22 77.2 0.2 2.0 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA21217.1 - 7.4e-10 38.9 0.1 1.6e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 SPRY domain DUF3587 PF12132.3 ESA21218.1 - 0.067 12.4 0.6 0.073 12.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3587) Pkinase_Tyr PF07714.12 ESA21219.1 - 8.4e-43 146.2 0.0 4.1e-39 134.2 0.0 4.3 4 0 0 4 4 4 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21219.1 - 1.6e-35 122.5 10.7 3e-34 118.3 0.8 4.6 5 1 0 5 5 5 2 Protein kinase domain BCS1_N PF08740.6 ESA21219.1 - 4.9e-05 23.0 0.0 0.08 12.5 0.0 4.0 4 0 0 4 4 4 1 BCS1 N terminal RnaseA PF00074.15 ESA21219.1 - 0.18 12.1 6.0 4.8 7.5 0.3 3.3 3 0 0 3 3 3 0 Pancreatic ribonuclease zf-RING_5 PF14634.1 ESA21220.1 - 0.013 15.1 0.8 0.028 14.1 0.5 1.5 1 0 0 1 1 1 0 zinc-RING finger domain SR-25 PF10500.4 ESA21221.1 - 0.022 14.2 10.0 0.022 14.2 6.9 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF1908 PF08926.6 ESA21221.1 - 0.078 11.7 1.4 0.088 11.5 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) Pet20 PF08692.5 ESA21221.1 - 0.099 12.5 0.1 1.3 8.9 0.0 2.0 1 1 1 2 2 2 0 Mitochondrial protein Pet20 ODV-E18 PF10717.4 ESA21221.1 - 0.16 11.3 1.8 0.29 10.5 1.3 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 SSP160 PF06933.6 ESA21221.1 - 4.7 5.0 8.4 5.7 4.7 5.8 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1117 PF06547.7 ESA21221.1 - 8.6 6.4 7.0 11 6.1 4.3 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1117) SH3_9 PF14604.1 ESA21222.1 - 5.7e-09 35.4 0.0 6.2e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 ESA21222.1 - 1.1e-06 27.8 0.0 1.2e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 ESA21222.1 - 0.00042 19.7 0.0 0.00045 19.6 0.0 1.1 1 0 0 1 1 1 1 Variant SH3 domain Antitoxin-MazE PF04014.13 ESA21222.1 - 0.0034 17.0 0.0 0.0044 16.7 0.0 1.2 1 0 0 1 1 1 1 Antidote-toxin recognition MazE TOBE PF03459.12 ESA21222.1 - 0.027 14.5 0.0 0.033 14.2 0.0 1.1 1 0 0 1 1 1 0 TOBE domain SH3_3 PF08239.6 ESA21222.1 - 0.037 14.2 0.1 0.044 13.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial SH3 domain Candida_ALS PF05792.8 ESA21222.1 - 0.038 14.1 0.1 0.053 13.6 0.1 1.2 1 0 0 1 1 1 0 Candida agglutinin-like (ALS) ABC_membrane_2 PF06472.10 ESA21223.1 - 9e-98 326.8 3.8 1.4e-97 326.1 2.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 ESA21223.1 - 9.6e-16 58.3 0.0 2.5e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_17 PF13207.1 ESA21223.1 - 0.00083 20.1 0.0 0.004 17.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 ESA21223.1 - 0.0057 16.6 0.0 0.021 14.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 ESA21223.1 - 0.0068 15.9 0.0 0.034 13.6 0.0 2.1 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 ESA21223.1 - 0.0076 16.2 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SbmA_BacA PF05992.7 ESA21223.1 - 0.029 13.5 0.1 0.052 12.7 0.1 1.3 1 0 0 1 1 1 0 SbmA/BacA-like family AAA_23 PF13476.1 ESA21223.1 - 0.036 14.4 2.9 0.67 10.2 2.0 2.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA21223.1 - 0.037 14.1 0.0 0.088 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 ESA21223.1 - 0.044 13.9 0.0 0.096 12.8 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESA21223.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 ESA21223.1 - 0.055 12.6 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 ESA21223.1 - 0.06 13.0 0.0 0.17 11.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SMC_N PF02463.14 ESA21223.1 - 0.061 12.5 0.0 1.6 7.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RuvB_N PF05496.7 ESA21223.1 - 0.066 12.2 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESA21223.1 - 0.11 12.3 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain NPV_P10 PF05531.7 ESA21223.1 - 0.11 12.7 0.1 0.37 11.0 0.1 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Sigma54_activ_2 PF14532.1 ESA21223.1 - 0.15 12.0 0.0 0.52 10.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain p450 PF00067.17 ESA21224.1 - 2.9e-14 52.4 0.0 3.3e-14 52.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Act-Frag_cataly PF09192.5 ESA21224.1 - 0.033 13.1 0.2 0.31 9.9 0.0 1.9 1 1 1 2 2 2 0 Actin-fragmin kinase, catalytic p450 PF00067.17 ESA21225.1 - 1.9e-08 33.3 0.0 1.9e-08 33.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.2 ESA21228.1 - 0.00027 20.6 1.3 0.00036 20.2 0.3 1.6 2 0 0 2 2 2 1 F-box-like DUF1387 PF07139.6 ESA21229.1 - 1.4 8.4 6.4 0.19 11.2 1.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) V-ATPase_H_N PF03224.9 ESA21230.1 - 1.8e-88 296.7 9.7 4.2e-88 295.4 5.7 1.9 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 ESA21230.1 - 2.2e-44 150.2 0.4 5.1e-43 145.7 0.1 2.8 2 0 0 2 2 2 1 V-ATPase subunit H HEAT_2 PF13646.1 ESA21230.1 - 2.8e-05 24.2 0.4 0.0056 16.9 0.0 3.4 3 1 0 3 3 3 1 HEAT repeats Arm_2 PF04826.8 ESA21230.1 - 0.0035 16.4 0.0 0.0093 15.1 0.0 1.7 1 0 0 1 1 1 1 Armadillo-like RAI16-like PF10257.4 ESA21230.1 - 0.012 14.6 0.1 0.02 13.8 0.0 1.5 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein HEAT PF02985.17 ESA21230.1 - 0.021 14.8 0.0 0.25 11.5 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat TyeA PF09059.5 ESA21230.1 - 0.034 14.0 0.9 7.1 6.6 0.0 3.1 3 0 0 3 3 3 0 TyeA Imm16 PF15565.1 ESA21230.1 - 0.05 13.4 1.8 0.48 10.3 0.0 3.2 4 0 0 4 4 4 0 Immunity protein 16 HEAT_EZ PF13513.1 ESA21230.1 - 0.067 13.7 0.1 6.2 7.4 0.1 3.2 3 0 0 3 3 3 0 HEAT-like repeat PX PF00787.19 ESA21231.1 - 2.7e-25 88.3 0.1 2.7e-25 88.3 0.1 2.9 3 0 0 3 3 3 1 PX domain Vps5 PF09325.5 ESA21231.1 - 1.4e-11 44.1 12.3 1.1e-05 24.7 1.3 2.6 3 0 0 3 3 3 2 Vps5 C terminal like SNF2_N PF00176.18 ESA21232.1 - 2.3e-73 246.6 0.6 4.2e-73 245.7 0.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 ESA21232.1 - 8.3e-14 51.2 0.1 2.7e-13 49.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HSA PF07529.8 ESA21232.1 - 1.2e-06 28.1 4.7 1.2e-06 28.1 0.4 2.7 2 0 0 2 2 2 1 HSA Kelch_5 PF13854.1 ESA21234.1 - 0.00017 21.4 0.0 0.0017 18.2 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 ESA21234.1 - 0.00059 19.5 0.4 0.014 15.1 0.0 3.0 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA21234.1 - 0.0015 18.6 2.8 0.0033 17.5 0.0 3.0 3 2 0 3 3 3 1 Kelch motif Kelch_1 PF01344.20 ESA21234.1 - 0.0017 17.8 0.7 0.013 15.0 0.0 2.6 2 2 0 2 2 2 1 Kelch motif Kelch_2 PF07646.10 ESA21234.1 - 0.0019 17.9 0.1 0.0094 15.6 0.0 2.2 3 0 0 3 3 3 1 Kelch motif CAF-1_p150 PF11600.3 ESA21235.1 - 1.2 8.4 3.6 1.7 8.0 2.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Transketolase_C PF02780.15 ESA21236.1 - 0.11 12.4 1.6 3.5 7.5 0.0 2.4 1 1 1 3 3 3 0 Transketolase, C-terminal domain DNA_pol_alpha_N PF12254.3 ESA21236.1 - 0.37 10.6 5.5 11 5.9 0.1 3.4 2 1 1 3 3 3 0 DNA polymerase alpha subunit p180 N terminal Helicase_C PF00271.26 ESA21237.1 - 2.4e-16 59.3 0.0 1.9e-14 53.2 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 ESA21237.1 - 5.9e-06 25.8 0.0 6e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DPM3 PF08285.6 ESA21238.1 - 0.02 14.7 0.4 0.045 13.5 0.3 1.6 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF2097 PF09870.4 ESA21238.1 - 0.074 13.1 0.2 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) SPX PF03105.14 ESA21239.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.0 1 0 0 1 1 1 0 SPX domain DDE_3 PF13358.1 ESA21240.1 - 2e-05 24.3 0.0 2.2e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease SPRY PF00622.23 ESA21241.1 - 1.6e-08 34.6 0.3 3.1e-08 33.7 0.2 1.4 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA21241.1 - 1.9e-05 24.6 0.3 6.4e-05 22.9 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain RhoGAP PF00620.22 ESA21242.1 - 2.1e-48 163.7 3.7 9.3e-48 161.6 0.0 3.0 3 0 0 3 3 3 1 RhoGAP domain LIM PF00412.17 ESA21242.1 - 1.1e-16 60.6 20.1 7.8e-10 38.6 6.1 3.2 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.17 ESA21242.1 - 3.8e-08 32.9 9.6 3.8e-08 32.9 6.7 4.4 4 0 0 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3945 PF13101.1 ESA21242.1 - 0.011 15.0 1.0 0.031 13.5 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) Abhydrolase_6 PF12697.2 ESA21243.1 - 1.1e-18 68.0 0.0 1.4e-18 67.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 ESA21243.1 - 4.6e-12 45.6 0.0 9.6e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 ESA21243.1 - 2.9e-10 40.0 0.0 6.1e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 ESA21243.1 - 9.9e-08 31.4 0.0 0.0033 16.6 0.0 3.3 2 1 1 3 3 3 3 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 ESA21243.1 - 3.8e-06 26.5 0.0 0.00012 21.6 0.0 2.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 ESA21243.1 - 5.8e-06 26.0 0.0 1.3e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 ESA21243.1 - 0.038 13.3 0.0 0.074 12.4 0.0 1.5 1 1 0 1 1 1 0 Putative esterase Surf_Ag_VNR PF07244.10 ESA21245.1 - 0.013 15.9 0.3 0.021 15.2 0.2 1.4 1 0 0 1 1 1 0 Surface antigen variable number repeat Acetyltransf_1 PF00583.19 ESA21246.1 - 2.3e-14 53.1 0.0 3.1e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA21246.1 - 3.3e-08 33.5 0.0 4.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA21246.1 - 3e-06 26.8 0.1 4.3e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 ESA21246.1 - 3.1e-06 27.3 0.0 3.9e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA21246.1 - 1.1e-05 25.3 0.0 1.4e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA21246.1 - 0.00097 19.3 0.0 0.0012 19.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA21246.1 - 0.028 14.3 0.1 0.032 14.1 0.1 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA21246.1 - 0.033 14.0 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain JTB PF05439.7 ESA21247.1 - 2.3e-06 27.3 3.3 8.5e-06 25.5 2.3 1.9 1 1 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) ABC2_membrane_3 PF12698.2 ESA21247.1 - 0.023 13.7 0.6 0.072 12.1 0.2 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein SIR2 PF02146.12 ESA21248.1 - 8.3e-45 152.6 0.0 1.2e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Med27 PF11571.3 ESA21248.1 - 0.0003 20.8 2.9 0.11 12.6 0.3 4.2 3 1 1 4 4 4 1 Mediator complex subunit 27 RRM_1 PF00076.17 ESA21249.1 - 1.4e-13 50.2 0.3 4.2e-13 48.7 0.2 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA21249.1 - 1.8e-11 43.6 0.0 2.8e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA21249.1 - 2.6e-07 30.5 0.1 5e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.1 ESA21249.1 - 0.012 15.1 0.0 0.015 14.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Calcipressin PF04847.7 ESA21249.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Calcipressin zf-RING-like PF08746.6 ESA21250.1 - 0.053 13.5 0.6 0.22 11.5 0.4 2.1 1 1 0 1 1 1 0 RING-like domain SAG PF04092.8 ESA21250.1 - 0.11 12.8 1.0 1.8 8.9 0.0 2.2 2 0 0 2 2 2 0 SRS domain DegQ PF08181.6 ESA21251.1 - 0.036 13.7 0.3 0.79 9.4 0.0 2.5 2 0 0 2 2 2 0 DegQ (SacQ) family Sel1 PF08238.7 ESA21253.1 - 4.1e-216 694.7 124.3 1.7e-12 47.5 0.6 23.0 23 0 0 23 23 23 23 Sel1 repeat TPR_17 PF13431.1 ESA21253.1 - 1.8e-13 49.5 42.9 12 6.3 0.0 19.4 20 0 0 20 20 20 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA21253.1 - 7.5e-12 44.8 73.7 0.18 12.3 0.2 16.9 18 0 0 18 18 16 6 Tetratricopeptide repeat Recep_L_domain PF01030.19 ESA21253.1 - 0.0064 16.4 0.6 14 5.7 0.0 5.1 5 1 2 7 7 7 0 Receptor L domain HemeBinding_Shp PF11545.3 ESA21253.1 - 0.0065 16.2 4.5 19 5.0 0.0 6.2 6 1 0 8 8 8 0 Cell surface heme-binding protein Shp DUF1843 PF08898.5 ESA21253.1 - 0.024 14.6 0.0 1.5e+02 2.5 0.0 5.9 7 0 0 7 7 7 0 Domain of unknown function (DUF1843) ApbA PF02558.11 ESA21253.1 - 0.033 13.6 0.2 35 3.8 0.0 5.2 5 2 2 8 8 8 0 Ketopantoate reductase PanE/ApbA Peptidase_C14 PF00656.17 ESA21253.1 - 0.044 13.4 0.0 13 5.4 0.0 4.6 5 1 0 5 5 5 0 Caspase domain Orthoreo_P10 PF07204.6 ESA21253.1 - 0.12 12.0 1.8 1e+02 2.7 0.0 5.5 6 1 0 7 7 7 0 Orthoreovirus membrane fusion protein p10 23S_rRNA_IVP PF05635.6 ESA21253.1 - 0.8 9.6 7.2 29 4.6 0.0 5.1 6 0 0 6 6 6 0 23S rRNA-intervening sequence protein ICAP-1_inte_bdg PF10480.4 ESA21253.1 - 1.6 8.4 12.5 1.8e+02 1.7 0.0 8.0 10 1 1 11 11 11 0 Beta-1 integrin binding protein RST PF12174.3 ESA21254.1 - 0.025 14.3 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain RPA_C PF08784.6 ESA21259.1 - 0.012 16.0 0.6 0.015 15.6 0.4 1.2 1 0 0 1 1 1 0 Replication protein A C terminal Baculo_44 PF04631.7 ESA21259.1 - 0.04 12.5 0.3 0.044 12.4 0.2 1.0 1 0 0 1 1 1 0 Baculovirus hypothetical protein Methyltransf_4 PF02390.12 ESA21260.1 - 0.0095 14.9 2.3 1.3 8.0 0.1 2.4 2 1 0 2 2 2 2 Putative methyltransferase DUF2321 PF10083.4 ESA21260.1 - 0.02 14.4 4.4 0.64 9.4 0.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) TF_Zn_Ribbon PF08271.7 ESA21260.1 - 0.024 13.9 3.9 2.6 7.4 0.1 2.7 2 0 0 2 2 2 0 TFIIB zinc-binding CpXC PF14353.1 ESA21260.1 - 0.026 14.4 4.5 3.4 7.6 0.7 3.1 2 1 0 3 3 3 0 CpXC protein TraT PF05818.7 ESA21260.1 - 0.052 12.9 2.7 1.9 7.8 0.1 2.1 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DZR PF12773.2 ESA21260.1 - 0.42 10.4 10.6 3.6 7.4 2.6 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 ESA21260.1 - 0.54 9.5 9.3 1.5 8.1 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 ESA21260.1 - 1.3 8.6 16.8 0.2 11.2 1.0 3.0 2 1 0 2 2 2 0 zinc-ribbon domain DUF4413 PF14372.1 ESA21260.1 - 6.1 6.8 11.4 0.13 12.2 1.5 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4413) BTB PF00651.26 ESA21261.1 - 4.2e-15 55.6 0.3 7.5e-15 54.8 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain Sel1 PF08238.7 ESA21262.1 - 6.7e-70 229.9 29.6 8.2e-10 39.0 0.2 9.2 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA21262.1 - 1.1e-06 28.6 12.6 2.4 8.8 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat RQC PF09382.5 ESA21262.1 - 0.022 14.4 4.0 0.43 10.3 0.2 3.8 2 2 1 3 3 3 0 RQC domain AviRa PF11599.3 ESA21262.1 - 0.14 11.1 1.4 3.2 6.6 0.0 3.0 2 1 2 4 4 4 0 RRNA methyltransferase AviRa Phage_terminase PF10668.4 ESA21262.1 - 1.4 8.7 15.6 24 4.8 0.0 6.6 7 1 1 8 8 8 0 Phage terminase small subunit BTB PF00651.26 ESA21263.1 - 6e-20 71.2 0.1 1.2e-19 70.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21263.1 - 6.7e-08 32.3 8.5 6.5e-05 22.7 0.4 4.7 4 1 1 5 5 5 2 BTB And C-terminal Kelch TLD PF07534.11 ESA21263.1 - 0.052 13.5 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 TLD Chlam_OMP6 PF03504.8 ESA21263.1 - 0.1 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 6 BTB PF00651.26 ESA21267.1 - 3.2e-07 30.3 0.0 3.6e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Asp_protease_2 PF13650.1 ESA21268.1 - 0.0013 19.1 0.0 0.0035 17.7 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease DUF1758 PF05585.7 ESA21268.1 - 0.051 13.1 1.3 0.41 10.1 0.0 2.5 2 1 1 3 3 3 0 Putative peptidase (DUF1758) Pkinase_Tyr PF07714.12 ESA21270.1 - 7.1e-36 123.5 0.1 1.8e-34 119.0 0.1 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21270.1 - 5.5e-33 114.2 0.9 1.1e-31 109.9 0.6 2.6 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA21270.1 - 0.0017 17.4 0.1 0.0027 16.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA21270.1 - 0.012 14.8 0.4 0.019 14.1 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA21270.1 - 0.026 13.8 0.1 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA21270.1 - 0.045 13.0 0.2 0.076 12.3 0.2 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 ESA21270.1 - 0.077 12.7 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family YjcQ PF09639.5 ESA21270.1 - 2.6 8.2 6.1 0.69 10.0 0.4 2.6 3 0 0 3 3 3 0 YjcQ protein TLD PF07534.11 ESA21272.1 - 2.5e-06 27.5 0.8 2.5e-06 27.5 0.5 1.6 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA21273.1 - 8.8e-18 64.3 0.0 1.5e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21273.1 - 4.8e-06 26.3 2.8 1.2e-05 25.0 0.3 2.7 2 2 2 4 4 4 1 BTB And C-terminal Kelch UBA_e1_C PF09358.5 ESA21274.1 - 0.00014 22.0 0.1 0.00018 21.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain PfkB PF00294.19 ESA21275.1 - 2.9e-05 23.3 0.0 3.3e-05 23.1 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase KH_1 PF00013.24 ESA21276.1 - 5.3e-39 131.6 8.7 9.3e-16 57.2 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 ESA21276.1 - 1.6e-26 91.4 11.7 2.3e-09 36.6 0.8 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 ESA21276.1 - 4.1e-10 39.0 5.3 0.017 14.6 0.1 3.6 3 1 0 3 3 3 3 KH domain KH_4 PF13083.1 ESA21276.1 - 1.4e-08 34.2 0.3 0.12 12.0 0.0 3.6 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 ESA21276.1 - 0.0028 17.4 4.1 0.53 10.1 0.0 3.5 3 0 0 3 3 3 1 NusA-like KH domain SMC_Nse1 PF07574.8 ESA21277.1 - 2.6e-29 102.3 2.4 3.6e-27 95.2 1.6 2.3 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 ESA21277.1 - 6.1e-11 42.1 12.0 9.9e-11 41.4 8.3 1.3 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.1 ESA21277.1 - 3.8e-06 26.6 9.0 6.3e-06 25.9 6.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-HC5HC2H_2 PF13832.1 ESA21277.1 - 0.0012 18.8 3.8 0.0024 17.8 2.6 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-rbx1 PF12678.2 ESA21277.1 - 0.0022 18.0 6.1 0.0045 17.0 4.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 ESA21277.1 - 0.0052 16.4 11.4 0.0087 15.7 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.1 ESA21277.1 - 0.0076 16.3 4.7 0.018 15.1 3.3 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain FYDLN_acid PF09538.5 ESA21277.1 - 0.008 16.7 7.9 0.017 15.6 5.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) zf-Apc11 PF12861.2 ESA21277.1 - 0.012 15.3 4.6 0.026 14.3 3.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2057 PF09829.4 ESA21277.1 - 0.033 13.8 0.8 0.28 10.7 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) zf-C3HC4_2 PF13923.1 ESA21277.1 - 0.039 13.9 10.1 0.064 13.3 7.0 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.6 ESA21277.1 - 2.1 8.2 8.3 1.7 8.5 3.0 2.4 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 ESA21277.1 - 3.2 7.7 9.1 11 6.1 6.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 ESA21277.1 - 9.1 6.4 9.5 18 5.4 6.6 1.5 1 0 0 1 1 1 0 RING-variant domain ubiquitin PF00240.18 ESA21279.1 - 2.5e-05 23.5 0.2 6.5e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.1 ESA21279.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2217 PF10265.4 ESA21279.1 - 0.012 14.4 1.5 0.018 13.8 1.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) DUF2407 PF10302.4 ESA21279.1 - 0.027 14.6 1.4 0.041 14.0 0.0 2.0 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain SR-25 PF10500.4 ESA21279.1 - 0.04 13.3 5.4 0.086 12.3 3.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.4 ESA21279.1 - 0.066 11.4 3.7 0.11 10.7 2.5 1.3 1 0 0 1 1 1 0 Transmembrane protein OmpH PF03938.9 ESA21280.1 - 0.0013 18.7 8.4 0.0017 18.3 5.8 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF1204 PF06721.6 ESA21280.1 - 0.0023 17.2 7.9 0.0043 16.3 5.5 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1204) V-SNARE PF05008.10 ESA21280.1 - 0.0094 16.0 3.8 0.0094 16.0 2.7 2.1 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Wx5_PLAF3D7 PF09688.5 ESA21280.1 - 0.0099 15.8 6.4 0.013 15.4 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (Wx5_PLAF3D7) DUF3583 PF12126.3 ESA21280.1 - 0.013 14.6 1.1 0.016 14.2 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) WXG100 PF06013.7 ESA21280.1 - 0.024 14.6 0.4 0.044 13.7 0.0 1.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF2046 PF09755.4 ESA21280.1 - 0.078 11.8 13.0 0.094 11.5 9.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) ApoO PF09769.4 ESA21280.1 - 0.12 12.0 0.2 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 Apolipoprotein O FAM110_N PF14161.1 ESA21280.1 - 0.14 12.4 0.4 0.22 11.8 0.3 1.4 1 0 0 1 1 1 0 Centrosome-associated N terminus TipAS PF07739.8 ESA21280.1 - 0.18 12.1 2.1 0.46 10.8 1.5 1.7 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DUF3347 PF11827.3 ESA21280.1 - 0.23 11.4 6.9 0.36 10.7 4.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) LOH1CR12 PF10158.4 ESA21280.1 - 0.25 11.1 5.9 0.11 12.3 1.3 2.0 1 1 1 2 2 2 0 Tumour suppressor protein DUF883 PF05957.8 ESA21280.1 - 0.27 11.6 1.1 0.52 10.7 0.8 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Nup54 PF13874.1 ESA21280.1 - 0.3 10.7 7.3 0.44 10.2 5.1 1.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF4375 PF14300.1 ESA21280.1 - 0.43 10.5 4.0 19 5.2 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) ING PF12998.2 ESA21280.1 - 0.51 10.6 10.6 0.3 11.3 5.8 1.8 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Allexi_40kDa PF05549.6 ESA21280.1 - 0.52 9.5 3.5 0.59 9.3 2.4 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF445 PF04286.7 ESA21280.1 - 0.66 9.4 8.4 0.77 9.2 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Exonuc_VII_L PF02601.10 ESA21280.1 - 1.2 8.3 8.8 1.3 8.1 6.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4163 PF13739.1 ESA21280.1 - 1.5 9.6 12.3 0.49 11.1 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4163) V_ATPase_I PF01496.14 ESA21280.1 - 1.9 6.2 9.4 2.2 6.0 6.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cut12 PF11500.3 ESA21280.1 - 4.1 7.0 12.3 2.8 7.6 1.6 2.3 1 1 1 2 2 2 0 Spindle pole body formation-associated protein SecA_DEAD PF07517.9 ESA21280.1 - 5.3 6.2 7.2 6.9 5.8 4.9 1.3 1 1 0 1 1 1 0 SecA DEAD-like domain cwf21 PF08312.7 ESA21280.1 - 5.3 6.9 10.2 4.7 7.1 4.0 2.4 1 1 1 2 2 2 0 cwf21 domain SieB PF14163.1 ESA21280.1 - 5.7 6.4 7.3 4 7.0 4.1 1.6 1 1 1 2 2 2 0 Superinfection exclusion protein B DUF607 PF04678.8 ESA21280.1 - 6.7 6.5 6.6 2.9 7.7 2.1 1.9 1 1 1 2 2 2 0 Protein of unknown function, DUF607 Ndc80_HEC PF03801.8 ESA21281.1 - 3.6e-39 133.7 0.1 6.8e-39 132.8 0.1 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family IncA PF04156.9 ESA21281.1 - 1.3e-05 24.9 1.6 1.6e-05 24.5 1.1 1.2 1 0 0 1 1 1 1 IncA protein TPR_MLP1_2 PF07926.7 ESA21281.1 - 6.5e-05 22.6 5.6 0.00011 21.8 3.9 1.4 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Fzo_mitofusin PF04799.8 ESA21281.1 - 9.9e-05 21.7 2.6 9.9e-05 21.7 1.8 2.5 2 1 1 3 3 2 1 fzo-like conserved region FlaC_arch PF05377.6 ESA21281.1 - 0.0031 17.3 1.3 0.0031 17.3 0.9 3.0 2 1 1 3 3 3 1 Flagella accessory protein C (FlaC) DUF1664 PF07889.7 ESA21281.1 - 0.0037 17.0 5.1 0.0078 16.0 3.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Myosin_tail_1 PF01576.14 ESA21281.1 - 0.0081 13.9 8.0 0.012 13.4 5.5 1.1 1 0 0 1 1 1 1 Myosin tail CENP-F_leu_zip PF10473.4 ESA21281.1 - 0.01 15.7 10.5 0.02 14.7 7.3 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4515 PF14988.1 ESA21281.1 - 0.024 14.3 9.7 0.029 14.0 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) Med10 PF09748.4 ESA21281.1 - 0.024 14.4 1.5 0.33 10.7 1.0 2.4 1 1 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex Allexi_40kDa PF05549.6 ESA21281.1 - 0.028 13.7 2.4 0.042 13.1 1.6 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.1 ESA21281.1 - 0.032 14.5 5.4 0.092 13.0 3.7 1.8 1 0 0 1 1 1 0 Snapin/Pallidin Spc7 PF08317.6 ESA21281.1 - 0.064 11.9 7.8 0.075 11.6 3.2 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.17 ESA21281.1 - 0.093 12.7 7.3 0.22 11.5 5.1 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF342 PF03961.8 ESA21281.1 - 0.11 10.8 5.6 0.16 10.3 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Phasin_2 PF09361.5 ESA21281.1 - 0.12 12.4 0.3 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 Phasin protein DUF4200 PF13863.1 ESA21281.1 - 0.14 12.1 12.4 0.32 10.9 1.2 2.6 2 1 1 3 3 2 0 Domain of unknown function (DUF4200) Laminin_II PF06009.7 ESA21281.1 - 0.14 11.9 2.8 0.29 10.9 1.9 1.5 1 0 0 1 1 1 0 Laminin Domain II DUF972 PF06156.8 ESA21281.1 - 0.14 12.5 5.8 0.38 11.1 4.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Prefoldin_2 PF01920.15 ESA21281.1 - 0.14 11.8 10.9 1.7 8.4 7.6 2.4 1 1 0 1 1 1 0 Prefoldin subunit OmpH PF03938.9 ESA21281.1 - 0.17 11.7 3.1 0.42 10.5 2.2 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BLOC1_2 PF10046.4 ESA21281.1 - 0.24 11.5 5.5 0.63 10.2 3.8 1.8 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YlqD PF11068.3 ESA21281.1 - 0.37 10.8 7.5 0.14 12.2 2.9 1.9 2 0 0 2 2 2 0 YlqD protein Spc42p PF11544.3 ESA21281.1 - 0.39 10.6 12.5 11 6.0 6.8 3.4 2 1 0 2 2 2 0 Spindle pole body component Spc42p NPV_P10 PF05531.7 ESA21281.1 - 0.4 10.9 2.9 5.2 7.3 0.4 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DivIVA PF05103.8 ESA21281.1 - 0.46 10.5 8.8 0.76 9.8 1.1 2.4 1 1 1 2 2 2 0 DivIVA protein DUF948 PF06103.6 ESA21281.1 - 0.52 10.1 3.3 10 6.0 2.3 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.6 ESA21281.1 - 0.57 10.6 5.3 1.5 9.2 3.5 1.9 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF4164 PF13747.1 ESA21281.1 - 0.61 10.2 4.9 5.8 7.1 3.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) NYD-SP28_assoc PF14775.1 ESA21281.1 - 0.93 9.2 6.0 20 4.9 0.2 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain Erp_C PF06780.6 ESA21281.1 - 0.94 9.3 9.3 0.8 9.5 5.2 1.8 2 0 0 2 2 1 0 Erp protein C-terminus DUF4145 PF13643.1 ESA21281.1 - 1.2 9.0 3.7 44 4.0 1.9 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4145) Spc24 PF08286.6 ESA21281.1 - 1.3 8.7 11.0 1.2 8.8 2.3 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF3552 PF12072.3 ESA21281.1 - 1.4 8.1 9.0 1.9 7.6 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) bZIP_1 PF00170.16 ESA21281.1 - 3 7.8 12.5 1.1 9.2 1.5 3.0 3 1 0 3 3 2 0 bZIP transcription factor TBPIP PF07106.8 ESA21281.1 - 5.8 6.4 13.2 1.3 8.5 1.6 2.8 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) RicinB_lectin_2 PF14200.1 ESA21282.1 - 0.12 12.7 0.9 0.33 11.3 0.5 1.8 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Kelch_3 PF13415.1 ESA21284.1 - 4.7e-07 29.8 0.0 0.026 14.6 0.0 2.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA21284.1 - 4.2e-06 26.5 0.0 0.0015 18.4 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.1 ESA21284.1 - 4.6e-06 26.3 0.9 0.0043 16.8 0.0 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA21284.1 - 0.0055 16.4 0.0 0.096 12.4 0.0 2.5 2 0 0 2 2 2 1 Kelch motif EphA2_TM PF14575.1 ESA21284.1 - 0.16 12.3 0.1 0.29 11.5 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Kelch_6 PF13964.1 ESA21284.1 - 0.32 11.2 6.4 5.9 7.2 0.0 3.8 4 1 0 4 4 4 0 Kelch motif Arrestin_N PF00339.24 ESA21285.1 - 4.4e-11 42.8 0.5 2.8e-10 40.1 0.0 2.5 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 ESA21285.1 - 0.00011 21.7 0.0 0.00031 20.2 0.0 1.7 2 0 0 2 2 2 1 Arrestin_N terminal like Oxidored_molyb PF00174.14 ESA21286.1 - 2e-53 180.3 0.0 2.7e-53 179.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 ESA21286.1 - 1.8e-47 160.2 0.0 2.9e-47 159.5 0.0 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.23 ESA21287.1 - 6.7e-15 54.6 0.0 8.6e-15 54.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Flagellar_rod PF05149.7 ESA21288.1 - 0.0067 15.6 0.2 0.0077 15.4 0.1 1.0 1 0 0 1 1 1 1 Paraflagellar rod protein DUF947 PF06102.7 ESA21288.1 - 0.011 15.5 1.9 0.012 15.3 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF947) CENP-B_N PF04218.8 ESA21288.1 - 0.013 14.8 0.0 0.037 13.4 0.0 1.8 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain MRP-L20 PF12824.2 ESA21288.1 - 0.043 13.7 0.1 0.08 12.9 0.0 1.5 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 DUF4413 PF14372.1 ESA21289.1 - 0.0023 17.8 1.6 1.3 9.0 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4413) BCS1_N PF08740.6 ESA21289.1 - 0.023 14.3 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 BCS1 N terminal Pkinase_Tyr PF07714.12 ESA21289.1 - 0.037 13.0 0.0 7.1 5.6 0.0 2.4 2 0 0 2 2 2 0 Protein tyrosine kinase LBR_tudor PF09465.5 ESA21289.1 - 0.05 13.2 0.3 2.5 7.7 0.0 2.8 3 0 0 3 3 3 0 Lamin-B receptor of TUDOR domain FYVE PF01363.16 ESA21289.1 - 0.05 13.4 3.3 1.4 8.8 0.1 2.5 2 0 0 2 2 2 0 FYVE zinc finger DUF3740 PF12548.3 ESA21289.1 - 0.19 11.9 1.3 14 5.9 0.0 2.3 2 0 0 2 2 2 0 Sulfatase protein DUF4047 PF13256.1 ESA21289.1 - 0.31 10.9 2.5 3.2 7.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DUF4116 PF13475.1 ESA21289.1 - 0.69 9.4 6.1 1.9 8.0 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4116) Zn_ribbon_2 PF12674.2 ESA21289.1 - 1.9 8.9 14.5 2.3 8.6 0.4 3.6 3 1 1 4 4 3 0 Putative zinc ribbon domain NOB1_Zn_bind PF08772.6 ESA21289.1 - 2.1 8.2 12.0 0.82 9.5 0.3 3.0 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like zf-ribbon_3 PF13248.1 ESA21289.1 - 3.1 7.1 14.1 4 6.7 0.6 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 ESA21289.1 - 9.5 6.1 15.1 6.1 6.7 0.5 2.4 2 0 0 2 2 2 0 Double zinc ribbon Pkinase_Tyr PF07714.12 ESA21291.1 - 6.8e-30 103.9 6.3 4.2e-23 81.7 0.0 7.0 8 0 0 8 8 8 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21291.1 - 3e-21 75.7 1.1 3e-21 75.7 0.7 5.8 7 0 0 7 7 7 1 Protein kinase domain zf-DBF PF07535.7 ESA21291.1 - 9.8e-07 28.3 57.1 0.15 11.7 0.4 9.5 8 1 0 8 8 8 6 DBF zinc finger Spt5-NGN PF03439.8 ESA21291.1 - 0.003 17.2 16.7 13 5.6 0.1 8.9 10 0 0 10 10 10 1 Early transcription elongation factor of RNA pol II, NGN section Phage_CI_repr PF07022.8 ESA21291.1 - 0.0052 16.8 0.0 28 4.8 0.0 4.6 5 0 0 5 5 5 0 Bacteriophage CI repressor helix-turn-helix domain BCS1_N PF08740.6 ESA21291.1 - 0.0057 16.2 10.0 4.4 6.8 0.0 5.7 6 0 0 6 6 6 2 BCS1 N terminal APH PF01636.18 ESA21291.1 - 0.017 14.8 0.1 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAYSvFN PF10260.4 ESA21291.1 - 0.04 13.6 7.5 0.89 9.3 0.0 4.9 5 0 0 5 5 5 0 Uncharacterized conserved domain (SAYSvFN) DUF4114 PF13448.1 ESA21291.1 - 0.15 12.8 23.2 0.5 11.2 0.1 7.1 7 0 0 7 7 7 0 Domain of unknown function (DUF4114) BCMA-Tall_bind PF09257.5 ESA21291.1 - 4.3 7.3 13.7 1.1e+02 2.8 0.1 5.5 5 0 0 5 5 5 0 BCMA, TALL-1 binding Shugoshin_N PF07558.6 ESA21293.1 - 9.5e-05 22.0 4.6 0.039 13.6 0.5 2.7 1 1 1 2 2 2 2 Shugoshin N-terminal coiled-coil region bZIP_1 PF00170.16 ESA21293.1 - 0.59 10.1 10.1 5.6 6.9 3.4 2.6 2 0 0 2 2 2 0 bZIP transcription factor Fmp27_WPPW PF10359.4 ESA21293.1 - 0.72 8.2 8.2 1 7.6 5.7 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3287 PF11690.3 ESA21293.1 - 1.8 8.6 4.8 21 5.2 0.3 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3287) TSC22 PF01166.13 ESA21293.1 - 2.5 8.1 13.3 0.067 13.1 2.5 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF904 PF06005.7 ESA21293.1 - 5.4 7.3 13.6 64 3.9 9.4 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Striatin PF08232.7 ESA21293.1 - 5.4 7.3 13.7 0.6 10.4 6.1 1.8 2 0 0 2 2 2 0 Striatin family IncA PF04156.9 ESA21293.1 - 8.1 5.9 10.6 13 5.3 7.3 1.3 1 0 0 1 1 1 0 IncA protein BTB PF00651.26 ESA21294.1 - 1.3e-19 70.2 1.0 2.2e-18 66.2 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA21294.1 - 1.3e-05 25.2 0.2 2.5e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA21294.1 - 0.0031 17.5 0.1 0.74 9.9 0.0 3.0 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain BTB PF00651.26 ESA21295.1 - 1.9e-13 50.3 0.3 4.5e-13 49.1 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21295.1 - 2.3e-08 33.7 9.1 2.3e-07 30.5 0.8 3.5 3 1 1 4 4 4 2 BTB And C-terminal Kelch TLD PF07534.11 ESA21295.1 - 9.8e-05 22.3 0.1 0.0018 18.2 0.0 2.6 3 0 0 3 3 3 1 TLD BTB PF00651.26 ESA21296.1 - 1.2e-18 67.1 0.1 2.2e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21296.1 - 2.6e-06 27.1 2.1 1.8e-05 24.5 0.1 3.0 3 1 1 4 4 4 1 BTB And C-terminal Kelch Ricin_B_lectin PF00652.17 ESA21296.1 - 0.00039 20.4 0.5 0.00069 19.6 0.4 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF3342 PF11822.3 ESA21296.1 - 0.0026 16.9 0.1 0.0041 16.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) RicinB_lectin_2 PF14200.1 ESA21296.1 - 0.029 14.7 0.5 0.1 12.9 0.1 1.8 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like DUF3315 PF11776.3 ESA21296.1 - 0.28 10.7 2.3 0.24 10.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3315) SPRY PF00622.23 ESA21297.1 - 5.5e-10 39.3 0.3 9.2e-10 38.6 0.2 1.3 1 0 0 1 1 1 1 SPRY domain BTB PF00651.26 ESA21297.1 - 7.9e-08 32.2 3.1 8e-07 29.0 0.2 2.3 2 0 0 2 2 2 2 BTB/POZ domain DUF2572 PF10833.3 ESA21298.1 - 0.11 11.9 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) DUF3741 PF12552.3 ESA21298.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) Upf2 PF04050.9 ESA21300.1 - 0.02 14.6 0.1 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 Up-frameshift suppressor 2 gag-asp_proteas PF13975.1 ESA21301.1 - 0.0054 16.5 0.0 0.0073 16.0 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA21301.1 - 0.007 16.8 0.0 0.0079 16.6 0.0 1.2 1 1 0 1 1 1 1 Aspartyl protease Endonuclease_7 PF02945.10 ESA21303.1 - 2.4e-07 30.3 1.2 2.4e-07 30.3 0.8 3.1 3 0 0 3 3 3 1 Recombination endonuclease VII E6 PF00518.12 ESA21303.1 - 0.01 16.1 8.9 0.051 13.9 6.1 2.4 1 1 0 1 1 1 0 Early Protein (E6) Suf PF05843.9 ESA21304.1 - 0.025 14.3 2.2 0.031 14.0 1.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MRP-L47 PF06984.8 ESA21304.1 - 0.058 13.2 0.1 0.099 12.5 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GreA_GreB_N PF03449.10 ESA21304.1 - 0.073 13.1 0.4 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Paramyxo_P PF01806.12 ESA21304.1 - 0.095 11.9 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Paramyxovirinae P phosphoprotein C-terminal region gag-asp_proteas PF13975.1 ESA21305.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA21305.1 - 0.082 13.4 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease USP7_C2 PF14533.1 ESA21306.1 - 0.074 12.4 0.0 0.077 12.4 0.0 1.0 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal DUF1660 PF07874.6 ESA21309.1 - 0.06 13.6 1.1 0.12 12.6 0.5 1.7 1 1 0 1 1 1 0 Prophage protein (DUF1660) Sporozoite_P67 PF05642.6 ESA21310.1 - 0.33 8.7 3.1 0.39 8.5 2.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAR1 PF03101.10 ESA21313.1 - 6.6e-08 32.9 0.8 3.1e-07 30.8 0.1 2.4 2 0 0 2 2 2 1 FAR1 DNA-binding domain DUF108 PF01958.13 ESA21315.1 - 0.12 12.6 0.0 3.4 7.9 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF108 E1_DerP2_DerF2 PF02221.10 ESA21316.1 - 0.031 14.5 0.0 0.053 13.7 0.0 1.6 1 1 0 1 1 1 0 ML domain DUF3449 PF11931.3 ESA21318.1 - 3.9e-71 238.6 1.0 4.2e-71 238.5 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) MCM PF00493.18 ESA21319.1 - 1.3e-132 441.6 0.0 1.9e-132 441.0 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 ESA21319.1 - 6.5e-22 78.2 3.2 8.7e-22 77.8 0.9 2.3 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.9 ESA21319.1 - 2.2e-08 33.8 0.0 7.1e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 ESA21319.1 - 2.6e-07 30.0 0.0 0.00054 19.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 ESA21319.1 - 0.00012 21.7 0.1 0.0013 18.2 0.0 2.6 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 ESA21319.1 - 0.001 18.5 0.1 4 6.8 0.0 3.2 3 0 0 3 3 3 2 Sigma-54 interaction domain Topoisom_I_N PF02919.10 ESA21319.1 - 0.065 12.5 0.8 0.17 11.1 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Myb_DNA-bind_3 PF12776.2 ESA21319.1 - 0.091 13.3 1.2 1.3 9.7 0.2 2.8 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Zn-ribbon_8 PF09723.5 ESA21319.1 - 0.11 12.4 0.8 0.24 11.3 0.6 1.6 1 0 0 1 1 1 0 Zinc ribbon domain YIF1 PF03878.10 ESA21320.1 - 3.9e-77 258.6 5.7 4.9e-77 258.3 4.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 ESA21320.1 - 1.2e-05 24.9 2.0 1.2e-05 24.9 1.4 1.4 2 0 0 2 2 2 1 Yip1 domain DUF3714 PF12508.3 ESA21320.1 - 0.065 12.6 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3714) VPS28 PF03997.7 ESA21321.1 - 2.5e-71 239.2 0.1 3e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 VPS28 protein MiaE_2 PF13794.1 ESA21321.1 - 0.0033 16.9 0.4 0.023 14.2 0.1 2.1 2 0 0 2 2 2 1 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like DUF4477 PF14780.1 ESA21321.1 - 0.06 12.7 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4477) DUF1128 PF06569.6 ESA21321.1 - 0.16 11.7 1.6 21 4.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1128) His_Phos_1 PF00300.17 ESA21322.1 - 2e-30 105.9 0.0 5e-30 104.6 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) LRR_6 PF13516.1 ESA21323.1 - 4.9e-09 35.3 11.1 0.0034 17.2 0.0 7.3 8 0 0 8 8 8 2 Leucine Rich repeat LRR_8 PF13855.1 ESA21323.1 - 2.9e-05 23.7 8.7 0.0026 17.4 0.0 4.3 4 1 1 5 5 5 1 Leucine rich repeat gag-asp_proteas PF13975.1 ESA21323.1 - 0.0016 18.2 0.0 0.0044 16.8 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease LRR_4 PF12799.2 ESA21323.1 - 0.0054 16.3 0.0 0.0054 16.3 0.0 4.8 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA21323.1 - 0.006 16.4 13.2 2.7 8.3 0.0 7.0 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_7 PF13504.1 ESA21323.1 - 0.0071 16.3 2.0 1.1e+02 3.7 0.0 5.7 6 0 0 6 6 6 0 Leucine rich repeat Asp_protease_2 PF13650.1 ESA21323.1 - 0.01 16.3 0.0 0.94 10.0 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease F-box-like PF12937.2 ESA21323.1 - 0.012 15.3 6.7 0.053 13.2 0.8 2.6 2 0 0 2 2 2 0 F-box-like RVP_2 PF08284.6 ESA21323.1 - 0.06 13.2 0.0 0.37 10.7 0.0 2.3 2 0 0 2 2 2 0 Retroviral aspartyl protease PPC PF04151.10 ESA21325.1 - 0.076 13.9 0.2 0.24 12.3 0.1 1.9 1 1 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain Shisa PF13908.1 ESA21325.1 - 0.082 13.0 1.4 0.13 12.3 1.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Big_3_4 PF13754.1 ESA21325.1 - 0.087 13.1 0.2 0.38 11.1 0.1 2.1 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) Adeno_E3_CR2 PF02439.10 ESA21325.1 - 0.39 10.2 4.9 0.75 9.3 3.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 MULE PF10551.4 ESA21326.1 - 0.00034 20.7 0.1 0.00097 19.2 0.0 1.8 2 0 0 2 2 2 1 MULE transposase domain SWIM PF04434.12 ESA21326.1 - 0.0017 17.7 0.1 0.0044 16.4 0.0 1.6 1 0 0 1 1 1 1 SWIM zinc finger SPRY PF00622.23 ESA21327.1 - 4e-08 33.4 0.2 4.4e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 SPRY domain Ifi-6-16 PF06140.8 ESA21334.1 - 9.7e-11 41.3 16.2 1.5e-10 40.7 11.2 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family ABC2_membrane_3 PF12698.2 ESA21334.1 - 3.3 6.6 12.6 4.8 6.1 8.7 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF726 PF05277.7 ESA21334.1 - 8.2 5.2 11.8 8.1 5.2 3.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF726) GlutR_N PF05201.10 ESA21335.1 - 0.066 12.7 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Helitron_like_N PF14214.1 ESA21336.1 - 2.5e-39 134.9 0.0 2.7e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus Pkinase_Tyr PF07714.12 ESA21338.1 - 0.00047 19.3 0.0 0.00065 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Shugoshin_N PF07558.6 ESA21341.1 - 0.0052 16.4 5.2 0.23 11.2 0.8 3.0 2 1 1 3 3 3 2 Shugoshin N-terminal coiled-coil region bZIP_1 PF00170.16 ESA21341.1 - 0.098 12.6 8.8 0.7 9.8 1.3 3.4 3 1 1 4 4 4 0 bZIP transcription factor BLOC1_2 PF10046.4 ESA21341.1 - 0.21 11.7 6.0 0.23 11.6 2.4 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GAS PF13851.1 ESA21341.1 - 0.61 9.2 11.3 0.13 11.4 4.8 2.1 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.3 ESA21341.1 - 0.71 9.7 15.0 0.067 13.0 1.6 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding bZIP_2 PF07716.10 ESA21341.1 - 0.79 9.5 11.8 5.6 6.8 0.1 3.7 1 1 2 3 3 3 0 Basic region leucine zipper DivIC PF04977.10 ESA21341.1 - 0.85 9.1 8.5 65 3.1 2.8 2.7 1 1 0 1 1 1 0 Septum formation initiator TSC22 PF01166.13 ESA21341.1 - 0.89 9.5 7.7 0.3 11.0 0.8 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF972 PF06156.8 ESA21341.1 - 1.6 9.1 7.7 5 7.5 5.0 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 ESA21341.1 - 1.9 8.0 10.1 3.9 7.0 7.0 1.5 1 0 0 1 1 1 0 IncA protein NYD-SP28_assoc PF14775.1 ESA21341.1 - 6.5 6.5 6.6 7.9 6.2 1.3 2.5 1 1 1 2 2 2 0 Sperm tail C-terminal domain AMP-binding PF00501.23 ESA21342.1 - 5.7e-87 291.7 0.0 1.4e-86 290.5 0.0 1.5 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESA21342.1 - 0.1 13.5 0.0 0.24 12.3 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Adaptin_N PF01602.15 ESA21343.1 - 6.6e-146 486.7 14.9 7.9e-146 486.4 10.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 ESA21343.1 - 1.6e-29 103.0 5.1 6.5e-28 97.7 0.1 3.0 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 ESA21343.1 - 8.5e-21 74.0 3.5 4.7e-06 26.7 0.0 6.1 1 1 3 5 5 5 5 HEAT repeats HEAT PF02985.17 ESA21343.1 - 1.1e-08 34.4 7.9 0.00069 19.4 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.1 ESA21343.1 - 2e-07 31.3 0.7 0.02 15.3 0.0 5.7 5 0 0 5 5 5 1 HEAT-like repeat CLASP_N PF12348.3 ESA21343.1 - 8.6e-06 25.2 2.0 0.031 13.6 0.0 4.2 3 1 1 5 5 5 2 CLASP N terminal Cnd3 PF12719.2 ESA21343.1 - 0.00075 18.5 2.0 0.0052 15.7 0.3 2.4 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Arm PF00514.18 ESA21343.1 - 0.0025 17.5 6.0 11 5.9 0.0 5.6 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat DUF1548 PF07579.6 ESA21343.1 - 0.0064 16.5 0.5 0.25 11.4 0.0 2.8 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1548) Arm_2 PF04826.8 ESA21343.1 - 0.016 14.2 3.6 0.015 14.4 0.9 2.0 2 1 0 2 2 2 0 Armadillo-like Atx10homo_assoc PF09759.4 ESA21343.1 - 0.13 11.9 1.9 20 5.0 0.0 3.8 4 1 0 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Pup PF05639.6 ESA21343.1 - 1.8 9.1 5.9 16 6.1 0.1 3.3 2 1 1 3 3 3 0 Pup-like protein DUF2458 PF10454.4 ESA21345.1 - 0.34 10.7 8.5 0.15 11.9 1.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2458) Tim17 PF02466.14 ESA21347.1 - 2.6e-12 46.9 3.7 3.8e-12 46.3 2.6 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NQR2_RnfD_RnfE PF03116.10 ESA21347.1 - 0.00075 18.7 2.0 0.00092 18.4 1.4 1.1 1 0 0 1 1 1 1 NQR2, RnfD, RnfE family Syntaxin_2 PF14523.1 ESA21348.1 - 9.5e-31 105.8 18.5 2.8e-29 101.1 7.5 2.3 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.14 ESA21348.1 - 2e-19 69.0 3.2 2e-19 69.0 2.2 2.9 4 0 0 4 4 3 1 SNARE domain Syntaxin PF00804.20 ESA21348.1 - 3.1e-07 30.4 6.5 3.1e-07 30.4 4.5 2.5 2 1 0 2 2 2 1 Syntaxin MCPsignal PF00015.16 ESA21348.1 - 0.00033 20.2 7.6 0.0086 15.6 1.3 2.2 1 1 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.7 ESA21348.1 - 0.022 14.5 9.4 0.096 12.4 0.8 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.7 ESA21348.1 - 0.05 13.8 7.7 0.95 9.7 0.3 3.1 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF2730 PF10805.3 ESA21348.1 - 0.053 13.2 6.1 0.16 11.6 0.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.7 ESA21348.1 - 0.076 12.8 12.9 0.15 11.9 1.1 2.9 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF812 PF05667.6 ESA21348.1 - 0.089 11.2 16.3 0.41 9.0 5.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Reo_sigmaC PF04582.7 ESA21348.1 - 0.24 10.5 3.9 2.6 7.1 0.1 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TMPIT PF07851.8 ESA21348.1 - 1.2 8.1 12.2 0.1 11.6 1.6 2.1 1 1 1 2 2 2 0 TMPIT-like protein Spectrin PF00435.16 ESA21348.1 - 1.2 9.4 11.1 2.8 8.2 0.4 2.8 1 1 2 3 3 3 0 Spectrin repeat TBPIP PF07106.8 ESA21348.1 - 1.6 8.2 14.6 1.8 8.0 2.2 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Cep57_CLD_2 PF14197.1 ESA21348.1 - 2 8.4 6.8 0.5 10.3 0.9 2.7 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Mgr1 PF08602.5 ESA21348.1 - 3.7 6.4 6.9 1.5 7.8 3.0 1.6 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit V-SNARE PF05008.10 ESA21348.1 - 3.9 7.7 9.9 0.32 11.1 0.9 3.4 2 2 2 4 4 4 0 Vesicle transport v-SNARE protein N-terminus DUF4404 PF14357.1 ESA21348.1 - 5.5 7.4 12.4 3.8 7.9 0.4 3.5 2 2 1 3 3 3 0 Domain of unknown function (DUF4404) DUF4200 PF13863.1 ESA21348.1 - 7.8 6.4 14.7 10 6.0 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) FlaC_arch PF05377.6 ESA21348.1 - 8.3 6.3 12.1 15 5.5 0.1 4.2 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Cauli_AT PF03233.8 ESA21348.1 - 9.3 5.9 11.6 36 4.0 0.0 3.5 2 2 1 3 3 3 0 Aphid transmission protein DNA_pol_A_exo1 PF01612.15 ESA21349.1 - 1.4e-19 70.2 0.0 2.7e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_L27e PF01777.13 ESA21350.1 - 1.2e-35 121.4 6.3 1.8e-35 120.9 4.4 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 ESA21350.1 - 5.9e-05 22.6 1.8 0.00013 21.5 1.2 1.7 1 0 0 1 1 1 1 KOW motif Big_4 PF07532.6 ESA21351.1 - 1.4 8.4 3.4 1.3 8.5 1.2 1.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) DUF2508 PF10704.4 ESA21351.1 - 1.7 8.9 5.1 41 4.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) MIT PF04212.13 ESA21352.1 - 0.088 12.6 0.2 0.088 12.6 0.1 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain BTB PF00651.26 ESA21353.1 - 3.7e-20 71.9 0.0 6.4e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA21353.1 - 0.0035 16.5 0.2 0.0048 16.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Skp1_POZ PF03931.10 ESA21353.1 - 0.054 13.5 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain WD40 PF00400.27 ESA21356.1 - 0.0078 16.0 0.0 0.13 12.2 0.0 2.5 2 1 0 2 2 2 1 WD domain, G-beta repeat IL1 PF00340.14 ESA21356.1 - 0.11 11.9 1.2 0.75 9.2 0.5 2.2 1 1 0 1 1 1 0 Interleukin-1 / 18 PepSY_2 PF13670.1 ESA21356.1 - 5 7.0 6.4 9.7 6.1 0.2 2.6 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain Pkinase_Tyr PF07714.12 ESA21357.1 - 7.2e-29 100.6 0.2 1.6e-24 86.3 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21357.1 - 1.2e-27 96.7 1.0 4.8e-25 88.1 0.2 2.8 1 1 1 2 2 2 2 Protein kinase domain DUF4247 PF14042.1 ESA21357.1 - 0.0032 17.4 2.8 0.081 12.9 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4247) APH PF01636.18 ESA21357.1 - 0.22 11.1 0.0 0.41 10.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DZR PF12773.2 ESA21357.1 - 0.31 10.8 4.0 0.94 9.3 0.4 2.5 2 0 0 2 2 2 0 Double zinc ribbon Peptidase_S8 PF00082.17 ESA21358.1 - 2.4e-37 128.6 3.7 3.2e-37 128.2 2.6 1.1 1 0 0 1 1 1 1 Subtilase family Arrestin_N PF00339.24 ESA21360.1 - 4.5e-12 46.0 0.1 1.2e-11 44.6 0.0 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain BHD_1 PF10403.4 ESA21360.1 - 0.1 12.1 0.1 0.33 10.5 0.1 1.8 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 LRR_2 PF07723.8 ESA21362.1 - 0.21 12.1 2.0 8.5 7.0 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_4 PF12799.2 ESA21362.1 - 0.56 9.8 0.1 0.56 9.8 0.1 4.4 3 2 0 3 3 3 0 Leucine Rich repeats (2 copies) FNIP PF05725.7 ESA21362.1 - 5.3 7.0 10.5 0.78 9.7 2.3 3.1 3 2 0 3 3 3 0 FNIP Repeat BTB_2 PF02214.17 ESA21363.1 - 2.4e-17 62.9 0.8 3.6e-17 62.3 0.5 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA21363.1 - 0.00015 21.7 0.1 0.00023 21.1 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3368 PF11848.3 ESA21363.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) DUF3763 PF12592.3 ESA21365.1 - 5.3 6.7 9.4 0.48 10.0 0.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3763) F-box PF00646.28 ESA21366.1 - 0.045 13.4 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 F-box domain eIF-1a PF01176.14 ESA21367.1 - 2.2e-28 97.4 0.1 3.2e-28 96.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pkinase_Tyr PF07714.12 ESA21368.1 - 9.4e-29 100.2 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21368.1 - 3.6e-25 88.6 0.0 5.1e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ORF6C PF10552.4 ESA21369.1 - 0.017 14.8 1.7 0.025 14.2 1.1 1.4 1 1 0 1 1 1 0 ORF6C domain DNA_pol_B_2 PF03175.8 ESA21369.1 - 0.041 12.5 1.2 0.046 12.4 0.8 1.0 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral IpaB_EvcA PF03278.8 ESA21369.1 - 0.041 13.1 1.1 0.052 12.7 0.8 1.1 1 0 0 1 1 1 0 IpaB/EvcA family DUF4116 PF13475.1 ESA21370.1 - 0.053 13.0 3.1 1.3 8.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4116) F-box-like PF12937.2 ESA21371.1 - 0.00065 19.3 0.4 0.00065 19.3 0.3 2.2 2 0 0 2 2 2 1 F-box-like DUF1936 PF09151.5 ESA21371.1 - 0.16 11.4 0.1 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) IBR PF01485.16 ESA21372.1 - 2.3e-20 72.2 29.5 1.6e-13 50.2 1.2 4.0 3 1 1 4 4 4 3 IBR domain zf-RING_2 PF13639.1 ESA21372.1 - 0.02 14.7 6.1 0.02 14.7 4.3 3.7 2 2 1 3 3 3 0 Ring finger domain C1_4 PF07975.7 ESA21372.1 - 0.04 13.9 1.4 0.04 13.9 1.0 3.9 3 2 1 4 4 4 0 TFIIH C1-like domain Transpos_assoc PF13963.1 ESA21372.1 - 0.056 13.4 0.1 0.056 13.4 0.1 3.2 3 1 1 4 4 4 0 Transposase-associated domain Lar_restr_allev PF14354.1 ESA21372.1 - 0.24 11.7 11.9 1.6 9.0 0.1 3.7 3 0 0 3 3 3 0 Restriction alleviation protein Lar zf-ISL3 PF14690.1 ESA21372.1 - 0.74 9.8 9.5 3.2 7.8 1.3 2.9 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_2 PF13240.1 ESA21372.1 - 9.2 5.8 11.1 2.4 7.7 0.0 4.3 4 1 0 4 4 4 0 zinc-ribbon domain ICE2 PF08426.5 ESA21374.1 - 0.4 9.2 7.2 0.13 10.8 3.2 1.5 1 1 1 2 2 2 0 ICE2 Fumarate_red_C PF02300.12 ESA21374.1 - 1.7 8.5 6.4 4.4 7.1 4.7 1.5 1 1 1 2 2 2 0 Fumarate reductase subunit C Endonuc_Holl PF10107.4 ESA21375.1 - 0.049 13.3 2.7 0.061 13.0 1.9 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF3987 PF13148.1 ESA21375.1 - 0.15 10.5 3.8 0.2 10.2 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Lyase_catalyt PF09093.6 ESA21375.1 - 0.58 8.9 3.0 0.71 8.7 2.1 1.1 1 0 0 1 1 1 0 Lyase, catalytic Ribosomal_S13 PF00416.17 ESA21375.1 - 0.99 9.8 8.0 1.6 9.2 5.2 1.5 1 1 0 1 1 1 0 Ribosomal protein S13/S18 DUF730 PF05325.6 ESA21375.1 - 1.6 8.5 5.2 2.4 7.9 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF730) 6PF2K PF01591.13 ESA21376.1 - 0.029 13.4 0.0 0.03 13.3 0.0 1.0 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Exo_endo_phos_2 PF14529.1 ESA21377.1 - 2.6e-10 39.9 1.0 2.6e-10 39.9 0.7 2.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA21377.1 - 8.1e-07 29.2 0.2 1.1e-05 25.5 0.0 2.5 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF3420 PF11900.3 ESA21379.1 - 0.044 13.8 1.2 0.57 10.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) HeLo PF14479.1 ESA21380.1 - 0.03 14.0 0.0 0.068 12.9 0.0 1.4 1 1 0 1 1 1 0 Prion-inhibition and propagation LLC1 PF14945.1 ESA21380.1 - 0.094 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein zf-BED PF02892.10 ESA21381.1 - 8.9e-08 31.7 0.9 1.5e-07 31.0 0.6 1.3 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.10 ESA21381.1 - 0.05 13.0 0.1 0.16 11.3 0.1 1.9 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.1 ESA21381.1 - 0.07 13.4 0.2 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA21381.1 - 0.075 13.3 2.2 0.26 11.6 1.5 2.0 1 0 0 1 1 1 0 Zinc-finger double domain DUF1775 PF07987.6 ESA21382.1 - 0.046 13.5 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unkown function (DUF1775) BPL_C PF02237.12 ESA21384.1 - 0.067 12.8 0.2 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Anophelin PF10731.4 ESA21386.1 - 0.24 11.5 3.2 0.56 10.3 2.2 1.6 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito Pkinase_Tyr PF07714.12 ESA21387.1 - 7.6e-42 143.1 0.0 9.1e-33 113.4 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21387.1 - 7.3e-38 130.1 6.0 5.1e-33 114.3 1.5 3.1 2 2 1 3 3 3 2 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA21387.1 - 0.0044 16.3 0.1 0.02 14.2 0.0 2.1 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA21387.1 - 0.0088 15.4 2.3 0.013 14.8 0.1 2.1 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA21387.1 - 0.01 14.9 0.5 0.036 13.1 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3860 PF12976.2 ESA21387.1 - 0.041 13.6 0.3 0.041 13.6 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3860) APH PF01636.18 ESA21387.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SSF PF00474.12 ESA21389.1 - 1.2e-15 57.0 15.6 1.2e-15 57.0 10.8 1.7 2 1 0 2 2 2 1 Sodium:solute symporter family Radical_SAM PF04055.16 ESA21390.1 - 3.3e-17 63.1 0.1 8.8e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 ESA21390.1 - 1.4e-10 41.0 0.0 3.9e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family E1_DerP2_DerF2 PF02221.10 ESA21391.1 - 1.8e-08 34.6 0.7 2.2e-08 34.4 0.5 1.1 1 0 0 1 1 1 1 ML domain DUF3505 PF12013.3 ESA21392.1 - 0.033 14.4 0.2 0.079 13.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3505) zf-C2H2 PF00096.21 ESA21392.1 - 0.23 11.8 5.1 0.3 11.5 2.7 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-BED PF02892.10 ESA21392.1 - 3.3 7.5 6.3 6.2 6.6 4.4 1.5 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_4 PF13894.1 ESA21392.1 - 5.9 7.4 5.6 0.77 10.2 1.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Pkinase_Tyr PF07714.12 ESA21395.1 - 3.9e-07 29.4 0.1 7.2e-07 28.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF577 PF04510.7 ESA21398.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF577) FAD_binding_3 PF01494.14 ESA21400.1 - 1.1e-24 87.1 0.0 1.8e-11 43.7 0.0 2.2 1 1 1 2 2 2 2 FAD binding domain DAO PF01266.19 ESA21400.1 - 2.8e-07 29.7 0.0 1.4e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.5 ESA21400.1 - 2.1e-05 23.5 0.0 3.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Trp_halogenase PF04820.9 ESA21400.1 - 6.6e-05 21.7 0.3 0.026 13.1 0.2 2.5 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.1 ESA21400.1 - 0.00023 21.1 0.2 0.0005 20.0 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 ESA21400.1 - 0.00053 20.3 0.2 0.029 14.7 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 ESA21400.1 - 0.022 14.5 0.1 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Strep_67kDa_ant PF06100.6 ESA21400.1 - 0.047 12.0 0.4 1.4 7.1 0.0 2.1 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family Lycopene_cycl PF05834.7 ESA21400.1 - 0.049 12.5 0.0 0.25 10.2 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.9 ESA21400.1 - 0.051 13.4 0.1 0.1 12.4 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 ESA21400.1 - 0.12 12.1 0.1 2 8.1 0.1 2.3 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Guanylate_cyc PF00211.15 ESA21400.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Thi4 PF01946.12 ESA21400.1 - 0.13 11.3 0.1 0.25 10.3 0.1 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.19 ESA21400.1 - 0.17 10.6 0.4 2.6 6.8 0.3 2.1 2 0 0 2 2 2 0 FAD binding domain Mis12 PF05859.7 ESA21401.1 - 2.9e-13 49.8 2.6 2.9e-13 49.8 1.8 1.7 2 0 0 2 2 2 1 Mis12 protein DOG1 PF14144.1 ESA21401.1 - 0.043 13.8 3.3 2.2 8.4 0.0 2.6 3 0 0 3 3 3 0 Seed dormancy control AMP-binding PF00501.23 ESA21402.1 - 2.4e-94 316.0 0.0 3.1e-94 315.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESA21402.1 - 0.022 15.7 0.0 0.047 14.6 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Ribonuc_red_lgC PF02867.10 ESA21403.1 - 3.3e-218 725.6 0.0 4.5e-218 725.1 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 ESA21403.1 - 3.3e-23 81.2 0.1 7.3e-23 80.1 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 ESA21403.1 - 3e-07 30.7 0.4 2e-06 28.1 0.0 2.6 3 0 0 3 3 3 1 ATP cone domain tRNA-synt_2d PF01409.15 ESA21404.1 - 1.7e-52 178.0 1.4 3.4e-29 101.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 ESA21404.1 - 2.9e-26 91.4 0.1 6.8e-26 90.2 0.1 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain HECT_2 PF09814.4 ESA21405.1 - 5.7e-37 127.2 4.6 7.3e-37 126.9 3.2 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Mu-like_Com PF10122.4 ESA21405.1 - 0.11 11.5 0.9 3.5 6.7 0.1 2.4 2 0 0 2 2 2 0 Mu-like prophage protein Com Rpr2 PF04032.11 ESA21405.1 - 2.4 8.1 6.2 2.9 7.8 0.4 3.0 3 0 0 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF1279 PF06916.8 ESA21406.1 - 2.8e-22 78.8 0.1 3.3e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Pkinase_Tyr PF07714.12 ESA21408.1 - 6.7e-29 100.7 0.0 8.5e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21408.1 - 1.5e-27 96.4 0.0 2.2e-27 95.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA21408.1 - 0.0091 15.7 0.3 0.014 15.1 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.20 ESA21409.1 - 6.6e-23 81.1 0.1 9.2e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21409.1 - 2e-18 66.3 0.0 2.5e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA21409.1 - 0.017 14.9 0.9 0.038 13.7 0.3 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.20 ESA21410.1 - 6.5e-39 133.6 0.2 8.2e-39 133.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21410.1 - 1.2e-37 129.3 0.0 1.9e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA21410.1 - 8.4e-05 21.6 0.0 0.0017 17.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like WaaY PF06176.6 ESA21410.1 - 0.00016 21.0 0.2 0.00024 20.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA21410.1 - 0.0071 15.7 1.7 0.034 13.4 1.2 2.0 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA21410.1 - 0.0091 15.0 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA21410.1 - 0.011 15.4 0.3 0.47 10.1 0.5 2.7 1 1 2 3 3 3 0 Phosphotransferase enzyme family GST_N_3 PF13417.1 ESA21411.1 - 8.7e-15 54.7 0.0 1.7e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA21411.1 - 9e-14 51.2 0.0 1.9e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA21411.1 - 1.5e-12 47.5 0.0 4.2e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA21411.1 - 1.5e-11 44.1 0.0 5.1e-11 42.3 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA21411.1 - 5.3e-07 29.4 0.0 9.1e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 ESA21411.1 - 1.8e-06 28.3 0.0 3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain F-box-like PF12937.2 ESA21413.1 - 4.9e-05 22.9 0.3 0.00015 21.4 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF3915 PF13054.1 ESA21413.1 - 0.55 10.1 5.3 7.8 6.4 0.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) F-box-like PF12937.2 ESA21414.1 - 6.5e-07 28.9 0.1 1.7e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA21415.1 - 0.00014 21.5 0.5 0.00049 19.7 0.4 1.9 1 0 0 1 1 1 1 F-box-like An_peroxidase PF03098.10 ESA21417.1 - 7.5e-79 265.5 0.0 2.3e-76 257.2 0.0 2.1 1 1 0 1 1 1 1 Animal haem peroxidase PH_6 PF15406.1 ESA21420.1 - 0.094 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4354 PF14263.1 ESA21420.1 - 0.099 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) SAM_1 PF00536.25 ESA21421.1 - 0.00014 21.9 0.0 0.00043 20.3 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RGS PF00615.14 ESA21422.1 - 0.012 15.6 0.1 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Regulator of G protein signaling domain Pkinase_Tyr PF07714.12 ESA21424.1 - 1.1e-23 83.6 0.1 1.4e-23 83.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21424.1 - 2.4e-23 82.6 0.4 3e-23 82.3 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1743 PF08489.6 ESA21424.1 - 0.063 13.0 0.1 0.13 11.9 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1743) Pkinase PF00069.20 ESA21425.1 - 2.1e-09 36.8 0.0 2.5e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21425.1 - 1e-08 34.6 0.0 1e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA21425.1 - 0.11 11.4 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PGM_PMM_II PF02879.11 ESA21429.1 - 0.11 12.8 0.0 0.77 10.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Peptidase_M22 PF00814.20 ESA21429.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycoprotease family Sel1 PF08238.7 ESA21431.1 - 5.5e-46 153.9 8.1 2.2e-11 43.9 0.1 6.3 6 0 0 6 6 6 6 Sel1 repeat Pkinase_Tyr PF07714.12 ESA21431.1 - 4.9e-13 48.7 0.0 8.3e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21431.1 - 4.5e-09 35.8 0.0 1.1e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain SipA PF09052.5 ESA21431.1 - 0.047 12.1 0.0 0.062 11.6 0.0 1.1 1 0 0 1 1 1 0 Salmonella invasion protein A SNARE PF05739.14 ESA21431.1 - 0.1 12.2 0.2 0.25 11.0 0.2 1.6 1 0 0 1 1 1 0 SNARE domain TPR_17 PF13431.1 ESA21431.1 - 0.22 11.8 4.7 8.9 6.7 0.2 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA21432.1 - 3.9e-94 307.0 28.6 7.2e-12 45.5 0.2 11.1 11 0 0 11 11 11 11 Sel1 repeat MIT PF04212.13 ESA21432.1 - 0.0099 15.7 9.4 6.4 6.7 0.0 5.4 4 1 0 4 4 4 2 MIT (microtubule interacting and transport) domain G10 PF01125.12 ESA21432.1 - 0.019 14.5 0.2 0.041 13.4 0.1 1.5 1 0 0 1 1 1 0 G10 protein z-alpha PF02295.12 ESA21432.1 - 0.045 13.5 0.1 18 5.2 0.0 3.3 3 1 1 4 4 4 0 Adenosine deaminase z-alpha domain Vhr1 PF04001.8 ESA21432.1 - 0.053 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Transcription factor Vhr1 TPR_11 PF13414.1 ESA21432.1 - 0.9 9.2 22.9 5.4 6.7 0.2 5.8 5 2 1 6 6 6 0 TPR repeat NSF PF02071.15 ESA21432.1 - 8.4 7.4 13.1 70 4.7 0.0 5.7 5 1 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Pkinase_Tyr PF07714.12 ESA21433.1 - 6.8e-52 176.0 0.0 1e-51 175.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21433.1 - 3.6e-49 167.2 0.0 6.4e-49 166.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA21433.1 - 0.00027 21.4 0.1 0.074 13.7 0.0 2.8 3 0 0 3 3 3 1 Sel1 repeat Kinase-like PF14531.1 ESA21433.1 - 0.00089 18.3 0.0 0.0076 15.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA21433.1 - 0.0015 17.9 0.2 0.0043 16.4 0.0 1.8 2 0 0 2 2 2 1 RIO1 family DUF1057 PF06342.7 ESA21433.1 - 0.0044 15.8 1.6 0.0071 15.2 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) APH PF01636.18 ESA21433.1 - 0.0048 16.6 0.2 0.018 14.8 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA21433.1 - 0.0055 15.7 0.0 0.0099 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family G10 PF01125.12 ESA21433.1 - 0.0074 15.8 0.3 0.019 14.5 0.2 1.8 1 0 0 1 1 1 1 G10 protein HTH_40 PF14493.1 ESA21435.1 - 0.15 12.3 6.5 0.19 11.9 0.7 3.1 2 1 0 2 2 2 0 Helix-turn-helix domain Chitin_synth_1 PF01644.12 ESA21436.1 - 7.3e-77 256.7 0.1 1.2e-76 256.0 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.10 ESA21436.1 - 4.6e-30 104.5 0.0 8.1e-23 80.5 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.6 ESA21436.1 - 2.4e-28 97.6 0.2 7e-28 96.1 0.1 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.1 ESA21436.1 - 1.5e-10 41.1 0.0 1.5e-10 41.1 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA21436.1 - 8e-08 32.3 0.0 2.7e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 BTB PF00651.26 ESA21439.1 - 2.7e-09 37.0 0.0 6.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21439.1 - 0.00016 21.4 3.2 0.0016 18.2 0.7 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch DDE_1 PF03184.14 ESA21440.1 - 5.1e-43 146.7 0.2 5.8e-43 146.5 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_1 PF03184.14 ESA21441.1 - 5.1e-37 127.1 0.5 5.7e-37 126.9 0.4 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease F-box-like PF12937.2 ESA21442.1 - 0.0081 15.8 2.9 0.015 14.9 0.7 2.3 2 0 0 2 2 2 1 F-box-like Pkinase_Tyr PF07714.12 ESA21443.1 - 0.00088 18.4 0.0 0.00088 18.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21443.1 - 0.015 14.4 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain DUF2250 PF10007.4 ESA21443.1 - 0.16 11.9 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) F-box-like PF12937.2 ESA21444.1 - 0.00057 19.5 1.7 0.001 18.7 1.2 1.4 1 0 0 1 1 1 1 F-box-like TLD PF07534.11 ESA21445.1 - 1.4e-06 28.3 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 TLD DUF2681 PF10883.3 ESA21447.1 - 0.0067 16.6 1.8 0.0096 16.1 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2681) DUF2051 PF09738.4 ESA21450.1 - 0.0042 16.4 0.1 0.0047 16.2 0.0 1.1 1 0 0 1 1 1 1 Double stranded RNA binding protein (DUF2051) Topoisom_I_N PF02919.10 ESA21450.1 - 0.0086 15.3 0.9 0.01 15.1 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Pkinase_Tyr PF07714.12 ESA21450.1 - 0.024 13.7 0.2 0.075 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein tyrosine kinase Cu-binding_MopE PF11617.3 ESA21450.1 - 0.045 13.5 0.8 2.3 8.0 0.2 2.4 2 0 0 2 2 2 0 Protein metal binding site F-box-like PF12937.2 ESA21451.1 - 0.0013 18.3 0.9 0.023 14.4 0.1 3.1 3 0 0 3 3 3 1 F-box-like EF-hand_7 PF13499.1 ESA21451.1 - 0.072 13.2 0.4 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain pair DUF972 PF06156.8 ESA21452.1 - 0.4 11.0 2.7 0.47 10.8 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) VIT PF08487.5 ESA21453.1 - 1.8e-22 79.2 0.9 3.7e-22 78.2 0.6 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.1 ESA21453.1 - 5.1e-11 41.8 0.0 9.8e-11 40.9 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF3438 PF11920.3 ESA21453.1 - 0.024 13.5 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) DUF91 PF01939.11 ESA21453.1 - 0.067 12.3 0.1 0.26 10.4 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF91 DUF619 PF04768.8 ESA21456.1 - 1.6e-49 167.5 0.0 2.8e-49 166.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF619) Acetyltransf_7 PF13508.1 ESA21456.1 - 0.032 14.3 0.0 0.097 12.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain dCMP_cyt_deam_1 PF00383.17 ESA21457.1 - 3e-24 84.6 0.1 4e-24 84.2 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 ESA21457.1 - 0.021 14.4 0.2 0.029 13.9 0.2 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain XOO_2897-deam PF14440.1 ESA21457.1 - 0.024 14.3 0.2 0.033 13.9 0.1 1.2 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase MafB19-deam PF14437.1 ESA21457.1 - 0.089 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 MafB19-like deaminase DpnD-PcfM PF14207.1 ESA21457.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 DpnD/PcfM-like protein YL1 PF05764.8 ESA21458.1 - 0.062 12.9 3.2 0.071 12.7 2.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF1218 PF06749.7 ESA21459.1 - 0.05 14.0 0.0 0.055 13.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) RNA_pol_Rpb4 PF03874.11 ESA21460.1 - 3.2e-19 69.0 2.5 5.7e-19 68.2 1.7 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb4 4HB_MCP_1 PF12729.2 ESA21460.1 - 0.0072 15.6 1.2 0.014 14.7 0.8 1.5 1 1 0 1 1 1 1 Four helix bundle sensory module for signal transduction DUF2533 PF10752.4 ESA21460.1 - 0.018 15.3 0.4 0.18 12.1 0.1 2.4 2 1 0 3 3 3 0 Protein of unknown function (DUF2533) BLUF PF04940.7 ESA21460.1 - 0.019 14.6 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Sensors of blue-light using FAD Pox_TAA1 PF03295.9 ESA21460.1 - 0.094 12.3 1.6 0.17 11.5 0.2 2.0 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal RNA_pol_Rpb1_1 PF04997.7 ESA21460.1 - 0.1 11.8 3.7 1.3 8.1 0.8 2.1 1 1 0 2 2 2 0 RNA polymerase Rpb1, domain 1 NAD_binding_5 PF07994.7 ESA21460.1 - 0.15 11.4 1.4 0.21 11.0 0.9 1.3 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase DUF972 PF06156.8 ESA21462.1 - 0.059 13.7 0.7 0.73 10.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) TcpQ PF10671.4 ESA21462.1 - 0.14 12.0 0.1 0.87 9.5 0.0 2.3 3 1 0 3 3 3 0 Toxin co-regulated pilus biosynthesis protein Q Pkinase PF00069.20 ESA21463.1 - 2.5e-06 26.8 0.0 2.9e-06 26.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21463.1 - 6.2e-06 25.4 0.0 7e-06 25.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase IBD PF10416.4 ESA21463.1 - 0.8 9.5 4.6 1.1 9.0 3.2 1.3 1 1 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD Pertus-S5-tox PF09276.5 ESA21465.1 - 0.085 12.8 0.5 49 3.9 0.0 3.1 1 1 2 3 3 3 0 Pertussis toxin S5 subunit Pheromone PF08015.6 ESA21469.1 - 5.9 7.8 5.9 2.7 8.8 1.7 1.9 2 0 0 2 2 2 0 Fungal mating-type pheromone Sigma54_AID PF00309.15 ESA21471.1 - 0.0086 15.5 3.5 0.016 14.6 2.4 1.4 1 0 0 1 1 1 1 Sigma-54 factor, Activator interacting domain (AID) PRESAN PF09687.5 ESA21471.1 - 0.032 14.2 3.2 0.038 14.0 2.2 1.0 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Interfer-bind PF09294.5 ESA21471.1 - 0.065 13.2 0.4 0.08 12.9 0.3 1.1 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Sigma54_AID PF00309.15 ESA21472.1 - 0.0077 15.6 2.7 0.017 14.5 1.9 1.6 1 0 0 1 1 1 1 Sigma-54 factor, Activator interacting domain (AID) DSHCT PF08148.7 ESA21472.1 - 0.03 13.5 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Vpu PF00558.14 ESA21472.1 - 0.34 10.5 3.2 0.69 9.5 2.2 1.5 1 0 0 1 1 1 0 Vpu protein RXT2_N PF08595.6 ESA21473.1 - 0.82 9.4 5.9 0.97 9.2 4.1 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4557 PF15101.1 ESA21476.1 - 0.029 14.2 2.0 0.035 13.9 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DUF2045 PF09741.4 ESA21476.1 - 0.051 12.6 0.2 0.056 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) Sed5p PF11416.3 ESA21476.1 - 0.4 10.1 5.8 1.1 8.7 4.0 1.7 1 0 0 1 1 1 0 Integral membrane protein Sed5p Tautomerase_2 PF14552.1 ESA21476.1 - 2.6 8.1 7.1 0.95 9.5 0.3 2.2 1 1 0 2 2 2 0 Tautomerase enzyme Sel1 PF08238.7 ESA21477.1 - 2e-07 31.4 0.1 2.7e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 Sel1 repeat KH_1 PF00013.24 ESA21478.1 - 2.1e-36 123.3 2.3 2.3e-13 49.5 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 ESA21478.1 - 1e-27 95.2 11.3 6.8e-11 41.5 0.8 3.7 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 ESA21478.1 - 2.2e-10 39.9 1.8 0.00037 19.9 0.4 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.1 ESA21478.1 - 6.9e-07 28.8 0.1 0.022 14.4 0.1 2.4 2 0 0 2 2 2 2 KH domain Sybindin PF04099.7 ESA21479.1 - 1e-23 83.6 0.2 1.2e-23 83.3 0.1 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 ESA21479.1 - 0.0011 18.8 0.2 0.0011 18.7 0.2 1.3 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region NOB1_Zn_bind PF08772.6 ESA21480.1 - 7.6e-31 105.7 1.8 2.1e-30 104.3 1.3 1.8 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Ogr_Delta PF04606.7 ESA21480.1 - 0.00056 19.5 1.2 0.0039 16.8 0.0 2.4 2 0 0 2 2 2 1 Ogr/Delta-like zinc finger AF1Q PF15017.1 ESA21480.1 - 0.0024 17.7 3.3 0.0025 17.6 1.0 1.9 1 1 0 1 1 1 1 Drug resistance and apoptosis regulator DZR PF12773.2 ESA21480.1 - 0.032 14.0 0.7 0.067 13.0 0.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon E6 PF00518.12 ESA21480.1 - 0.034 14.4 1.3 0.11 12.8 0.9 1.8 1 0 0 1 1 1 0 Early Protein (E6) zf-ribbon_3 PF13248.1 ESA21480.1 - 0.057 12.6 1.2 0.12 11.6 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbon domain SDA1 PF05285.7 ESA21481.1 - 0.0051 16.1 3.3 0.0064 15.8 2.3 1.2 1 0 0 1 1 1 1 SDA1 DUF3542 PF12061.3 ESA21483.1 - 0.0097 14.9 0.1 0.013 14.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3542) TM140 PF14985.1 ESA21483.1 - 0.083 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 TM140 protein family SpoVR PF04293.8 ESA21484.1 - 0.45 8.8 5.9 0.5 8.6 4.1 1.1 1 0 0 1 1 1 0 SpoVR like protein DUF342 PF03961.8 ESA21484.1 - 0.58 8.5 6.5 0.62 8.4 4.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Mnd1 PF03962.10 ESA21484.1 - 3.5 7.2 10.3 4.4 6.9 7.2 1.1 1 0 0 1 1 1 0 Mnd1 family DUF4407 PF14362.1 ESA21484.1 - 7.9 5.3 9.2 9.5 5.0 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.11 ESA21484.1 - 8.8 4.7 5.9 10 4.5 4.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Arch_ATPase PF01637.13 ESA21488.1 - 1.1e-09 38.3 1.8 1.1e-09 38.3 0.5 1.7 2 0 0 2 2 2 1 Archaeal ATPase AAA_18 PF13238.1 ESA21488.1 - 1.3e-05 25.5 0.5 0.0018 18.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 ESA21488.1 - 3.6e-05 23.9 0.0 0.00012 22.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF853 PF05872.7 ESA21488.1 - 0.00035 19.0 0.0 0.00085 17.7 0.0 1.6 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) AAA PF00004.24 ESA21488.1 - 0.0013 18.9 0.1 0.0042 17.2 0.1 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA21488.1 - 0.002 18.9 0.7 0.0077 17.0 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA21488.1 - 0.0048 16.9 0.0 0.032 14.2 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 ESA21488.1 - 0.013 14.5 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus ANTAR PF03861.9 ESA21488.1 - 0.024 14.2 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 ANTAR domain Sigma54_activat PF00158.21 ESA21488.1 - 0.033 13.6 0.0 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.9 ESA21488.1 - 0.038 13.6 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 ESA21488.1 - 0.049 12.5 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.1 ESA21488.1 - 0.058 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain CRC_subunit PF08624.5 ESA21488.1 - 0.067 13.1 0.3 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Cytidylate_kin2 PF13189.1 ESA21488.1 - 0.088 12.7 1.2 0.18 11.7 0.1 2.1 2 1 0 2 2 2 0 Cytidylate kinase-like family AAA_23 PF13476.1 ESA21488.1 - 0.28 11.4 5.3 2.2 8.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain DDE_1 PF03184.14 ESA21489.1 - 6.3e-35 120.2 2.0 3.1e-29 101.6 0.6 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease CENP-B_N PF04218.8 ESA21489.1 - 0.00062 19.1 0.2 0.00062 19.1 0.2 2.2 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.11 ESA21489.1 - 0.0022 17.7 0.0 0.01 15.6 0.0 2.2 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DLD PF14878.1 ESA21489.1 - 0.0085 16.1 1.2 0.72 9.9 0.0 3.1 3 0 0 3 3 3 1 Death-like domain of SPT6 DDE_3 PF13358.1 ESA21489.1 - 0.023 14.4 0.6 0.063 13.0 0.1 2.0 2 0 0 2 2 2 0 DDE superfamily endonuclease Sec20 PF03908.8 ESA21489.1 - 0.25 11.0 2.2 0.56 9.9 0.4 2.4 2 0 0 2 2 2 0 Sec20 YbaJ PF10757.4 ESA21490.1 - 0.1 12.7 1.7 0.14 12.2 1.2 1.4 1 1 0 1 1 1 0 Biofilm formation regulator YbaJ Glyco_tran_WecB PF03808.8 ESA21490.1 - 0.14 11.5 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family XFP_C PF09363.5 ESA21490.1 - 0.25 10.7 2.1 0.3 10.5 1.0 1.5 1 1 1 2 2 2 0 XFP C-terminal domain tRNA-synt_1 PF00133.17 ESA21491.1 - 5.3e-209 695.1 0.6 4.5e-207 688.7 0.0 2.9 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 ESA21491.1 - 5.9e-26 91.0 0.4 1.9e-25 89.4 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 ESA21491.1 - 2.5e-17 62.6 3.3 3.9e-06 25.7 0.2 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 ESA21491.1 - 0.00034 19.8 0.1 0.0013 17.9 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain TEP1_N PF05386.6 ESA21491.1 - 0.11 11.9 0.3 0.23 10.9 0.2 1.5 1 0 0 1 1 1 0 TEP1 N-terminal domain NTF2 PF02136.15 ESA21492.1 - 6.2e-11 42.7 0.0 1.2e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 ESA21492.1 - 1.1e-09 37.7 0.6 4.4e-09 35.8 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA21492.1 - 3.7e-07 30.0 0.1 9.5e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA21492.1 - 6.1e-05 22.7 0.7 0.00013 21.6 0.5 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA21492.1 - 0.00023 20.9 1.5 0.00081 19.2 0.1 2.4 2 0 0 2 2 2 1 RNA binding motif ACT PF01842.20 ESA21492.1 - 0.027 13.9 0.0 0.064 12.7 0.0 1.6 1 0 0 1 1 1 0 ACT domain ComX PF05952.7 ESA21492.1 - 0.047 13.1 0.0 0.17 11.4 0.0 1.9 1 0 0 1 1 1 0 Bacillus competence pheromone ComX SUR7 PF06687.7 ESA21493.1 - 4.5e-18 65.5 11.4 6.4e-18 65.1 6.7 1.9 1 1 1 2 2 2 1 SUR7/PalI family Abhydrolase_9_N PF15420.1 ESA21493.1 - 0.26 11.0 1.4 0.56 9.9 1.0 1.5 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF1218 PF06749.7 ESA21493.1 - 1.1 9.8 6.3 5.9 7.4 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) SCIMP PF15050.1 ESA21493.1 - 2.8 7.8 6.3 8.8 6.2 1.5 2.8 3 1 0 3 3 3 0 SCIMP protein Skp1 PF01466.14 ESA21494.1 - 1e-38 131.2 1.1 1.6e-38 130.5 0.7 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 ESA21494.1 - 1.4e-23 82.7 1.5 1.8e-23 82.3 0.5 1.6 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain RBM39linker PF15519.1 ESA21494.1 - 0.044 14.0 0.1 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein BTB PF00651.26 ESA21494.1 - 0.066 13.2 0.0 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 BTB/POZ domain UTP15_C PF09384.5 ESA21494.1 - 0.088 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 UTP15 C terminal DUF4375 PF14300.1 ESA21494.1 - 0.091 12.7 0.5 0.28 11.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) FTH PF01827.22 ESA21495.1 - 0.0025 17.4 0.4 0.0068 16.0 0.3 1.7 1 1 0 1 1 1 1 FTH domain Pkinase PF00069.20 ESA21497.1 - 3.8e-08 32.8 0.0 4.9e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21497.1 - 1.2e-07 31.0 0.0 1.5e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TLD PF07534.11 ESA21498.1 - 2.2e-05 24.4 0.0 4.2e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 TLD DUF4559 PF15112.1 ESA21499.1 - 2.8 7.0 17.9 5.1 6.1 12.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) PAP1 PF08601.5 ESA21500.1 - 7.4e-19 68.6 0.4 7.4e-19 68.6 0.3 3.3 2 1 1 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.16 ESA21500.1 - 4.1e-11 42.6 11.1 1.3e-10 41.0 7.7 1.9 1 0 0 1 1 1 1 bZIP transcription factor TSC22 PF01166.13 ESA21500.1 - 0.0073 16.2 3.6 0.021 14.7 2.5 1.8 1 0 0 1 1 1 1 TSC-22/dip/bun family FlaC_arch PF05377.6 ESA21500.1 - 0.014 15.2 2.2 0.039 13.8 1.5 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 ESA21500.1 - 0.018 14.5 3.4 0.041 13.3 2.4 1.6 1 0 0 1 1 1 0 Septum formation initiator dsrm PF00035.20 ESA21500.1 - 0.055 14.0 0.2 0.18 12.4 0.0 2.0 2 0 0 2 2 2 0 Double-stranded RNA binding motif bZIP_2 PF07716.10 ESA21500.1 - 0.085 12.6 19.9 0.95 9.3 13.8 2.4 1 1 0 1 1 1 0 Basic region leucine zipper Adeno_PIX PF03955.9 ESA21500.1 - 0.086 13.3 1.7 0.28 11.7 1.2 1.8 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Glutaredoxin2_C PF04399.8 ESA21500.1 - 0.18 11.3 6.5 0.031 13.8 1.5 1.8 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain DUF4407 PF14362.1 ESA21500.1 - 2.5 6.9 6.7 3.8 6.3 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Suf PF05843.9 ESA21501.1 - 0.0032 17.2 6.4 0.0041 16.9 4.5 1.1 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) CAF-1_p150 PF11600.3 ESA21501.1 - 0.13 11.6 0.7 0.19 11.1 0.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal zf-BED PF02892.10 ESA21504.1 - 1.2e-05 24.9 3.5 2e-05 24.2 2.4 1.4 1 0 0 1 1 1 1 BED zinc finger SLY PF12485.3 ESA21504.1 - 0.011 15.9 0.5 0.016 15.4 0.3 1.4 1 1 0 1 1 1 0 Lymphocyte signaling adaptor protein Pkinase_Tyr PF07714.12 ESA21505.1 - 2.7e-41 141.3 0.0 3e-41 141.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21505.1 - 1.5e-40 139.0 0.1 1.6e-40 138.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA21505.1 - 0.056 12.6 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.18 ESA21505.1 - 0.064 12.9 0.1 0.091 12.4 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family APH_6_hur PF04655.9 ESA21505.1 - 0.11 11.5 0.3 0.2 10.7 0.1 1.4 2 0 0 2 2 2 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase YchF-GTPase_C PF06071.8 ESA21505.1 - 0.14 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF933) FYVE PF01363.16 ESA21506.1 - 2.1e-09 37.1 2.1 2.7e-09 36.8 1.4 1.2 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 ESA21506.1 - 0.027 14.3 2.5 0.038 13.8 1.8 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger Armet PF10208.4 ESA21506.1 - 0.054 13.1 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding SAP30_Sin3_bdg PF13867.1 ESA21506.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 HypA PF01155.14 ESA21506.1 - 0.47 10.1 4.6 1.2 8.8 3.2 1.6 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-C2HC5 PF06221.8 ESA21506.1 - 3.3 7.5 11.1 29 4.5 7.6 2.1 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-B_box PF00643.19 ESA21506.1 - 8.9 6.2 8.7 24 4.9 6.0 1.7 1 1 0 1 1 1 0 B-box zinc finger PMM PF03332.8 ESA21507.1 - 7.8e-110 365.6 1.1 8.9e-110 365.4 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 ESA21507.1 - 9.4e-05 22.0 0.0 0.0006 19.4 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TMPIT PF07851.8 ESA21507.1 - 0.0029 16.7 0.0 0.0041 16.2 0.0 1.2 1 0 0 1 1 1 1 TMPIT-like protein S6PP PF05116.8 ESA21507.1 - 0.018 14.3 0.0 0.35 10.1 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.21 ESA21507.1 - 0.02 15.3 0.0 0.028 14.8 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 ESA21507.1 - 0.052 13.4 0.0 0.1 12.5 0.0 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Indigoidine_A PF04227.7 ESA21509.1 - 3.1e-20 72.6 0.7 5.6e-19 68.4 0.4 2.6 2 1 0 2 2 2 1 Indigoidine synthase A like protein PfkB PF00294.19 ESA21509.1 - 4.3e-18 65.4 0.0 2.7e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 pfkB family carbohydrate kinase DUF1293 PF06950.6 ESA21509.1 - 0.087 12.7 0.1 0.49 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1293) DUF805 PF05656.9 ESA21510.1 - 0.17 11.7 3.8 2.5 7.9 2.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF805) ETRAMP PF09716.5 ESA21510.1 - 0.23 11.4 2.6 1.7 8.6 1.8 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1772 PF08592.6 ESA21510.1 - 1.6 8.4 5.7 0.25 11.0 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) BTB PF00651.26 ESA21511.1 - 0.0028 17.6 0.5 0.0052 16.7 0.4 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.27 ESA21512.1 - 0.011 15.5 0.0 0.039 13.8 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat PRD PF00874.15 ESA21512.1 - 0.54 10.4 4.0 0.28 11.3 0.3 2.3 2 1 0 2 2 2 0 PRD domain TPT PF03151.11 ESA21513.1 - 4e-31 107.7 25.9 4.8e-28 97.7 7.2 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 ESA21513.1 - 8.4e-16 57.7 27.4 1.3e-15 57.1 19.0 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 ESA21513.1 - 3.1e-11 43.4 35.5 6.1e-07 29.5 10.2 2.8 2 1 1 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.10 ESA21513.1 - 6.5e-05 22.1 4.2 6.5e-05 22.1 2.9 2.2 2 0 0 2 2 2 1 Nucleotide-sugar transporter EmrE PF13536.1 ESA21513.1 - 0.0045 17.1 5.4 0.0045 17.1 3.8 3.6 2 1 1 3 3 3 2 Multidrug resistance efflux transporter Pkinase_Tyr PF07714.12 ESA21514.1 - 3.4e-41 141.0 0.0 4.4e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21514.1 - 3.7e-41 141.0 0.0 1.9e-40 138.6 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Choline_kinase PF01633.15 ESA21514.1 - 0.045 13.3 0.1 0.087 12.3 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 ESA21514.1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB_2 PF02214.17 ESA21516.1 - 0.017 15.2 1.4 0.07 13.3 1.1 1.7 1 1 0 1 1 1 0 BTB/POZ domain Pkinase PF00069.20 ESA21517.1 - 9.4e-15 54.4 0.1 1.1e-14 54.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21517.1 - 4.1e-10 39.1 0.0 4.5e-10 39.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Thioredoxin_8 PF13905.1 ESA21518.1 - 0.067 13.3 0.2 0.1 12.7 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like Pkinase PF00069.20 ESA21519.1 - 1.7e-22 79.8 0.9 3.2e-22 78.9 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21519.1 - 4.4e-22 78.4 0.0 6.9e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase BCS1_N PF08740.6 ESA21519.1 - 0.00012 21.7 0.0 0.32 10.5 0.0 2.2 2 0 0 2 2 2 2 BCS1 N terminal DUF187 PF02638.10 ESA21519.1 - 0.0027 16.5 1.1 0.06 12.2 0.3 2.2 1 1 1 2 2 2 1 Glycosyl hydrolase like GH101 DUF2439 PF10382.4 ESA21519.1 - 0.0038 17.3 3.2 1.9 8.7 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2439) APH PF01636.18 ESA21519.1 - 0.032 13.9 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family SHS2_Rpb7-N PF03876.12 ESA21519.1 - 0.13 12.3 0.1 0.54 10.4 0.0 2.0 2 0 0 2 2 2 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 TLD PF07534.11 ESA21520.1 - 1e-05 25.5 0.7 2e-05 24.5 0.1 1.8 2 0 0 2 2 2 1 TLD CD34_antigen PF06365.7 ESA21521.1 - 0.011 15.3 0.6 0.015 14.9 0.4 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family Yopt PF09467.5 ESA21521.1 - 0.056 13.3 0.1 0.099 12.5 0.1 1.4 1 0 0 1 1 1 0 Hypothetical protein Yopt DUF2535 PF10751.4 ESA21522.1 - 0.057 13.5 0.5 0.074 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2535) MAP7 PF05672.6 ESA21524.1 - 0.0016 17.8 3.4 0.0018 17.7 2.4 1.1 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family ScpA_ScpB PF02616.9 ESA21524.1 - 0.0071 15.9 1.6 0.0089 15.6 1.1 1.1 1 0 0 1 1 1 1 ScpA/B protein DUF1682 PF07946.9 ESA21524.1 - 0.24 10.2 5.3 0.32 9.8 3.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) YtxH PF12732.2 ESA21524.1 - 1.2 9.5 4.9 2.7 8.4 3.4 1.7 1 1 0 1 1 1 0 YtxH-like protein Sec5 PF15469.1 ESA21525.1 - 0.022 14.5 0.4 0.053 13.2 0.2 1.6 1 1 0 1 1 1 0 Exocyst complex component Sec5 Histone PF00125.19 ESA21526.1 - 1.9e-23 82.3 0.0 2.4e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA21526.1 - 9.5e-06 25.5 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1931 PF09123.6 ESA21526.1 - 0.0054 16.6 0.1 0.0064 16.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1931) TFIID-18kDa PF02269.11 ESA21526.1 - 0.084 12.6 0.1 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit BTB PF00651.26 ESA21527.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF3776 PF12618.3 ESA21527.1 - 0.061 13.8 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3776) TPR_11 PF13414.1 ESA21529.1 - 1.7e-99 325.5 50.0 2.8e-13 49.3 0.0 12.2 7 3 6 13 13 13 13 TPR repeat TPR_2 PF07719.12 ESA21529.1 - 3.7e-87 279.3 48.2 8.6e-06 25.2 0.0 21.3 21 1 1 22 22 21 15 Tetratricopeptide repeat TPR_1 PF00515.23 ESA21529.1 - 8.4e-87 281.5 65.0 6.3e-07 28.7 0.0 20.5 21 0 0 21 21 21 15 Tetratricopeptide repeat TPR_9 PF13371.1 ESA21529.1 - 6.8e-60 198.8 8.0 1.8e-09 37.3 0.1 13.6 5 3 9 14 14 14 12 Tetratricopeptide repeat TPR_16 PF13432.1 ESA21529.1 - 2.2e-58 193.8 5.9 2.4e-07 31.2 0.1 11.0 10 1 1 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.1 ESA21529.1 - 1.2e-53 174.8 66.7 0.0034 17.0 0.0 19.6 18 3 3 21 21 20 15 Tetratricopeptide repeat TPR_14 PF13428.1 ESA21529.1 - 3.4e-40 132.8 9.6 0.0062 17.0 0.1 16.7 10 5 9 19 19 17 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21529.1 - 7.8e-40 134.6 45.9 0.0001 22.1 0.0 13.9 3 1 13 17 17 17 13 Tetratricopeptide repeat TPR_17 PF13431.1 ESA21529.1 - 5.4e-35 116.6 35.6 0.011 15.8 0.1 18.1 18 1 1 19 19 19 6 Tetratricopeptide repeat TPR_19 PF14559.1 ESA21529.1 - 5.9e-33 113.0 35.6 0.0002 21.6 0.0 11.2 8 3 5 13 13 12 11 Tetratricopeptide repeat Apc3 PF12895.2 ESA21529.1 - 1e-21 76.8 39.6 1.9e-05 24.7 0.7 9.2 3 2 6 10 10 10 8 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 ESA21529.1 - 6.7e-18 64.7 16.7 3.7e-05 22.9 0.1 9.3 3 3 6 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESA21529.1 - 3.7e-14 51.3 29.2 0.42 10.5 0.0 15.4 19 0 0 19 19 17 3 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA21529.1 - 2.7e-12 45.6 38.0 0.22 10.8 0.0 14.7 17 0 0 17 17 17 4 SHNi-TPR TPR_20 PF14561.1 ESA21529.1 - 5.9e-10 39.1 21.0 0.044 13.8 0.6 9.3 6 3 2 9 9 8 3 Tetratricopeptide repeat NARP1 PF12569.3 ESA21529.1 - 7.8e-09 34.8 30.3 0.02 13.6 0.0 9.0 2 1 5 10 10 10 6 NMDA receptor-regulated protein 1 TPR_21 PF09976.4 ESA21529.1 - 2e-08 34.2 22.2 0.045 13.6 1.9 8.2 6 3 2 9 9 8 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA21529.1 - 2.1e-08 33.8 27.1 0.039 13.8 0.0 11.0 10 2 2 12 12 12 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 ESA21529.1 - 2.1e-08 34.0 36.4 2.2 8.9 0.0 15.7 18 0 0 18 18 17 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 ESA21529.1 - 2.7e-05 24.4 5.8 0.032 14.4 0.0 5.2 5 0 0 5 5 5 1 Alkyl sulfatase dimerisation TPR_10 PF13374.1 ESA21529.1 - 0.00035 20.3 9.4 7 6.7 0.2 8.6 9 0 0 9 9 8 0 Tetratricopeptide repeat KorB PF08535.5 ESA21529.1 - 0.0013 18.8 4.9 5.9 7.1 0.0 5.1 5 1 1 6 6 4 0 KorB domain Mga PF05043.8 ESA21529.1 - 0.0013 18.9 4.6 8.9 6.6 0.0 5.7 4 1 0 4 4 4 0 Mga helix-turn-helix domain MIT PF04212.13 ESA21529.1 - 0.0037 17.1 12.9 9.6 6.1 0.0 8.4 5 4 3 8 8 8 0 MIT (microtubule interacting and transport) domain Syntaxin-6_N PF09177.6 ESA21529.1 - 0.008 16.5 14.3 2.4 8.5 0.1 7.0 4 2 2 7 7 7 1 Syntaxin 6, N-terminal ChAPs PF09295.5 ESA21529.1 - 0.016 14.0 6.6 19 3.8 0.1 4.8 1 1 4 6 6 6 0 ChAPs (Chs5p-Arf1p-binding proteins) GrpE PF01025.14 ESA21529.1 - 0.02 14.4 1.6 0.12 11.9 1.1 2.4 1 0 0 1 1 1 0 GrpE DUF3407 PF11887.3 ESA21529.1 - 0.065 12.5 0.8 4.6 6.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3407) CDT1 PF08839.6 ESA21529.1 - 0.12 12.3 6.1 3.4 7.5 0.4 4.0 3 1 0 3 3 3 0 DNA replication factor CDT1 like TPR_3 PF07720.7 ESA21529.1 - 0.38 10.6 0.0 0.38 10.6 0.0 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat NTase_sub_bind PF08780.6 ESA21529.1 - 1.1 8.9 8.5 1.4e+02 2.2 0.0 7.0 8 3 0 8 8 7 0 Nucleotidyltransferase substrate binding protein like CR6_interact PF10147.4 ESA21529.1 - 2.1 7.5 9.1 4.8 6.4 0.7 3.9 3 1 1 4 4 4 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 CotJB PF12652.2 ESA21529.1 - 5.3 7.1 7.3 28 4.8 0.0 4.6 4 1 0 5 5 4 0 CotJB protein Ras PF00071.17 ESA21530.1 - 2.3e-60 202.6 0.5 2.8e-60 202.3 0.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA21530.1 - 4.8e-21 75.4 0.1 8.9e-21 74.5 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 ESA21530.1 - 2.7e-16 59.3 0.1 3.4e-16 58.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA21530.1 - 4.3e-08 32.8 0.2 2e-07 30.6 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 ESA21530.1 - 1.4e-06 27.6 0.1 1.8e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESA21530.1 - 6.6e-06 25.4 0.2 7.8e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 ESA21530.1 - 2e-05 24.4 0.1 3.6e-05 23.6 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 ESA21530.1 - 0.0029 17.1 0.1 0.014 14.9 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.1 ESA21530.1 - 0.0084 16.2 0.1 1.2 9.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.13 ESA21530.1 - 0.011 15.0 0.3 0.32 10.2 0.2 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.1 ESA21530.1 - 0.032 14.1 0.1 7.9 6.4 0.0 2.2 1 1 0 2 2 2 0 AAA domain MobB PF03205.9 ESA21530.1 - 0.061 13.0 0.1 3 7.5 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 ESA21530.1 - 0.073 12.7 0.1 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 Archaeal ATPase DnaJ-X PF14308.1 ESA21531.1 - 4.2e-54 182.9 1.9 1.7e-53 180.9 1.2 1.9 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 ESA21531.1 - 3.9e-26 90.5 1.7 3.9e-26 90.5 1.1 2.3 2 0 0 2 2 2 1 DnaJ domain PARP PF00644.15 ESA21532.1 - 5.5e-10 39.0 0.3 2.8e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.21 ESA21532.1 - 2e-06 27.2 0.0 6.2e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA21532.1 - 0.0071 16.2 0.0 0.019 14.8 0.0 1.7 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 ESA21532.1 - 0.06 13.1 0.0 0.2 11.3 0.0 1.9 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF2457 PF10446.4 ESA21532.1 - 0.23 10.1 15.8 0.41 9.3 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.9 ESA21532.1 - 1.8 8.0 7.5 3.7 7.0 5.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein 14-3-3 PF00244.15 ESA21533.1 - 1.1e-117 391.2 6.1 1.3e-117 391.0 4.2 1.0 1 0 0 1 1 1 1 14-3-3 protein TerB PF05099.8 ESA21533.1 - 0.042 13.5 0.7 0.042 13.5 0.5 2.0 2 0 0 2 2 2 0 Tellurite resistance protein TerB HisKA PF00512.20 ESA21533.1 - 0.1 12.6 0.6 2 8.4 0.1 2.8 2 1 1 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF837 PF05769.6 ESA21533.1 - 0.25 10.8 5.3 1.1 8.7 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF837) BTB PF00651.26 ESA21534.1 - 3.5e-20 72.0 0.7 5.9e-20 71.3 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA21534.1 - 0.00096 18.9 6.9 0.0034 17.2 0.6 3.0 4 0 0 4 4 4 2 BTB And C-terminal Kelch zf-Di19 PF05605.7 ESA21536.1 - 0.064 13.3 1.1 0.1 12.7 0.7 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Laminin_EGF PF00053.19 ESA21536.1 - 0.093 12.6 3.7 0.13 12.2 2.5 1.2 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) DUF3279 PF11682.3 ESA21536.1 - 0.15 11.6 5.0 0.22 11.0 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3279) Brr6_like_C_C PF10104.4 ESA21536.1 - 0.5 9.8 2.6 0.73 9.3 1.8 1.1 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain zf-C2H2_jaz PF12171.3 ESA21536.1 - 1.2 9.3 8.0 2.7 8.2 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding MACPF PF01823.14 ESA21538.1 - 3.4e-08 33.4 1.3 3.4e-08 33.4 0.9 1.7 2 0 0 2 2 2 1 MAC/Perforin domain FoP_duplication PF13865.1 ESA21539.1 - 3.1e-10 40.3 4.1 3.7e-10 40.0 2.8 1.1 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Gly-rich_Ago1 PF12764.2 ESA21539.1 - 3 8.5 8.3 3.7 8.2 5.7 1.3 1 1 0 1 1 1 0 Glycine-rich region of argonaut Pkinase_Tyr PF07714.12 ESA21540.1 - 1.2e-20 73.6 0.9 2.2e-20 72.8 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21540.1 - 5.7e-17 61.7 4.3 5.7e-17 61.7 3.0 2.2 2 1 0 2 2 2 1 Protein kinase domain UBN2_3 PF14244.1 ESA21543.1 - 0.018 14.6 1.1 0.018 14.6 0.7 2.8 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type Neurensin PF14927.1 ESA21544.1 - 0.00028 20.2 0.0 0.00037 19.8 0.0 1.3 1 0 0 1 1 1 1 Neurensin IFP_35_N PF07334.8 ESA21544.1 - 0.0077 16.1 2.7 0.012 15.5 1.5 1.7 1 1 0 1 1 1 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus CENP-F_N PF10481.4 ESA21544.1 - 0.011 15.1 0.1 0.015 14.7 0.1 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain DUF3573 PF12097.3 ESA21544.1 - 0.019 13.5 0.5 0.024 13.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF904 PF06005.7 ESA21544.1 - 0.023 14.9 1.8 0.042 14.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Folate_carrier PF01770.13 ESA21544.1 - 0.048 12.1 0.1 0.056 11.9 0.1 1.0 1 0 0 1 1 1 0 Reduced folate carrier Siah-Interact_N PF09032.6 ESA21544.1 - 0.059 13.4 0.4 0.1 12.6 0.3 1.4 1 0 0 1 1 1 0 Siah interacting protein, N terminal CENP-F_leu_zip PF10473.4 ESA21544.1 - 0.059 13.2 1.1 0.085 12.7 0.7 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T4SS PF07996.6 ESA21544.1 - 0.062 13.1 0.4 0.085 12.7 0.3 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins TPD52 PF04201.10 ESA21544.1 - 0.085 12.5 0.3 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 Tumour protein D52 family DUF1192 PF06698.6 ESA21544.1 - 0.13 12.0 0.1 0.23 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DivIC PF04977.10 ESA21544.1 - 0.26 10.8 1.8 0.48 9.9 1.2 1.6 1 1 0 1 1 1 0 Septum formation initiator IncA PF04156.9 ESA21544.1 - 5.1 6.6 6.9 15 5.1 0.4 2.0 1 1 1 2 2 2 0 IncA protein TRP PF06011.7 ESA21545.1 - 6.1e-43 147.0 14.3 1.2e-42 146.0 9.9 1.4 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF1510 PF07423.6 ESA21545.1 - 0.0012 18.2 8.6 0.0043 16.4 1.8 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1510) DUF605 PF04652.11 ESA21545.1 - 0.0018 17.7 9.8 0.0028 17.1 6.8 1.2 1 0 0 1 1 1 1 Vta1 like DUF1003 PF06210.6 ESA21545.1 - 0.07 13.0 3.0 0.095 12.6 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1003) E1_DerP2_DerF2 PF02221.10 ESA21545.1 - 0.52 10.5 6.5 0.068 13.4 1.3 1.8 2 0 0 2 2 2 0 ML domain CDC45 PF02724.9 ESA21545.1 - 1.2 7.0 7.9 2 6.3 5.5 1.2 1 0 0 1 1 1 0 CDC45-like protein F-box-like PF12937.2 ESA21546.1 - 0.00056 19.5 3.2 0.00088 18.9 0.7 2.6 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.2 ESA21546.1 - 0.0058 16.2 1.4 0.63 9.7 0.0 3.8 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA21546.1 - 0.0065 16.4 2.1 0.5 10.6 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_8 PF13855.1 ESA21546.1 - 0.012 15.3 0.1 0.37 10.5 0.0 3.3 2 0 0 2 2 2 0 Leucine rich repeat PRANC PF09372.5 ESA21546.1 - 0.033 14.1 0.1 0.033 14.1 0.1 3.2 4 0 0 4 4 4 0 PRANC domain LRR_1 PF00560.28 ESA21546.1 - 0.057 13.4 0.2 9.6 6.6 0.1 3.8 2 0 0 2 2 2 0 Leucine Rich Repeat MULE PF10551.4 ESA21548.1 - 9.5e-10 38.5 0.0 1.7e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain LRR_8 PF13855.1 ESA21549.1 - 8.2e-08 31.8 3.9 0.0012 18.5 0.0 3.3 3 1 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 ESA21549.1 - 1.1e-07 31.3 3.7 0.0014 18.2 0.0 3.7 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 ESA21549.1 - 4.1e-05 23.0 0.9 1.1 9.7 0.0 4.6 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 ESA21549.1 - 0.00016 21.4 7.1 1.8 8.8 0.0 5.0 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.28 ESA21549.1 - 0.0011 18.6 5.7 0.49 10.6 0.1 4.9 4 2 1 5 5 5 2 Leucine Rich Repeat LacAB_rpiB PF02502.13 ESA21550.1 - 7.2e-19 67.8 0.0 1.1e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Cupin_2 PF07883.6 ESA21550.1 - 2.9e-07 29.8 3.3 4.9e-07 29.1 2.3 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_7 PF12973.2 ESA21550.1 - 0.00014 21.6 0.3 0.00028 20.6 0.2 1.5 1 0 0 1 1 1 1 ChrR Cupin-like domain DUF4437 PF14499.1 ESA21550.1 - 0.0086 15.0 0.0 0.021 13.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4437) bZIP_2 PF07716.10 ESA21551.1 - 6.8e-10 38.6 9.8 9.3e-10 38.1 6.8 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.16 ESA21551.1 - 1.6e-07 31.1 9.6 2e-07 30.8 6.7 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.12 ESA21551.1 - 0.012 15.9 2.5 0.015 15.5 1.7 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF3984 PF13136.1 ESA21551.1 - 0.03 13.5 8.6 0.032 13.4 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) PsbW PF07123.7 ESA21551.1 - 0.061 13.3 1.1 0.08 12.9 0.8 1.1 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) Cep57_CLD_2 PF14197.1 ESA21551.1 - 0.19 11.6 5.4 0.38 10.7 3.7 1.5 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 DUF904 PF06005.7 ESA21552.1 - 0.027 14.7 0.0 0.029 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF4367 PF14285.1 ESA21552.1 - 0.049 12.9 0.5 0.051 12.8 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) ADH_N PF08240.7 ESA21554.1 - 2.6e-29 101.1 0.5 4.5e-29 100.3 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 ESA21554.1 - 1.6e-19 69.7 0.0 2.7e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 ESA21554.1 - 0.0044 17.5 0.1 0.01 16.4 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain AlaDh_PNT_C PF01262.16 ESA21554.1 - 0.0046 16.5 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain PrmA PF06325.8 ESA21554.1 - 0.012 14.7 0.1 0.018 14.1 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ADH_N_assoc PF13823.1 ESA21554.1 - 0.015 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated Methyltransf_31 PF13847.1 ESA21554.1 - 0.038 13.5 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AAA_11 PF13086.1 ESA21555.1 - 9e-15 54.8 0.0 1.1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA21555.1 - 2.7e-06 27.0 0.0 4.6e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA21555.1 - 0.00032 19.8 0.0 0.00043 19.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.16 ESA21555.1 - 0.00038 19.8 0.0 0.00067 19.0 0.0 1.4 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_30 PF13604.1 ESA21555.1 - 0.00071 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA21555.1 - 0.0034 17.3 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ResIII PF04851.10 ESA21555.1 - 0.0038 17.0 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_17 PF13207.1 ESA21555.1 - 0.0059 17.4 0.1 0.013 16.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 ESA21555.1 - 0.006 16.8 1.3 0.067 13.4 0.9 2.3 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 ESA21555.1 - 0.014 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.1 ESA21555.1 - 0.018 15.1 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESA21555.1 - 0.021 14.2 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESA21555.1 - 0.033 13.3 0.0 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.24 ESA21555.1 - 0.058 13.6 1.3 0.77 9.9 0.5 2.4 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zot PF05707.7 ESA21555.1 - 0.081 12.3 0.1 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) ETC_C1_NDUFA5 PF04716.9 ESA21555.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 ETC complex I subunit conserved region KaiC PF06745.8 ESA21555.1 - 0.14 11.2 0.0 0.35 9.9 0.0 1.7 1 1 1 2 2 2 0 KaiC DGCR6 PF07324.6 ESA21556.1 - 0.024 14.1 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein FoP_duplication PF13865.1 ESA21557.1 - 4.9 7.6 6.3 8.6 6.8 4.4 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 YlaH PF14036.1 ESA21558.1 - 0.27 11.3 2.2 0.38 10.8 1.5 1.2 1 0 0 1 1 1 0 YlaH-like protein DUF4448 PF14610.1 ESA21559.1 - 0.0043 16.5 1.9 0.036 13.5 1.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) Chromo PF00385.19 ESA21563.1 - 1.3e-15 56.7 1.7 7.4e-15 54.3 1.2 2.4 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.14 ESA21563.1 - 5.6e-11 42.1 0.0 1.8e-08 34.1 0.0 2.7 2 0 0 2 2 2 2 Chromo shadow domain Ifi-6-16 PF06140.8 ESA21564.1 - 3e-10 39.7 15.3 4.6e-10 39.1 10.6 1.3 1 0 0 1 1 1 1 Interferon-induced 6-16 family Ifi-6-16 PF06140.8 ESA21566.1 - 4.6e-05 23.1 2.4 4.6e-05 23.1 1.7 1.8 2 0 0 2 2 2 1 Interferon-induced 6-16 family ABC2_membrane_3 PF12698.2 ESA21566.1 - 0.61 9.0 4.3 1 8.3 3.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2552 PF10827.3 ESA21569.1 - 0.013 15.4 0.3 0.019 14.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2552) EST1 PF10374.4 ESA21570.1 - 0.029 14.3 6.8 0.055 13.4 4.7 1.6 1 0 0 1 1 1 0 Telomerase activating protein Est1 DUF2518 PF10726.4 ESA21570.1 - 0.044 13.3 0.0 0.095 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of function (DUF2518) Telomere_Sde2 PF13019.1 ESA21570.1 - 0.12 12.0 2.0 0.12 12.0 0.5 1.7 2 0 0 2 2 2 0 Telomere stability and silencing DUF496 PF04363.7 ESA21570.1 - 0.39 10.5 6.3 0.14 12.0 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF496) Methyltransf_24 PF13578.1 ESA21571.1 - 2.1e-22 79.9 0.0 3e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 ESA21571.1 - 1.2e-10 40.8 0.2 1.5e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase CmcI PF04989.7 ESA21571.1 - 0.00043 19.6 0.0 0.00059 19.2 0.0 1.1 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_31 PF13847.1 ESA21571.1 - 0.0024 17.4 0.2 0.0031 17.1 0.1 1.3 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 ESA21571.1 - 0.014 14.8 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DUF1447 PF07288.6 ESA21571.1 - 0.11 12.3 0.7 0.24 11.2 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) MAT_Alpha1 PF04769.7 ESA21572.1 - 0.01 15.2 0.4 0.015 14.6 0.2 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 BTB PF00651.26 ESA21573.1 - 2.1e-19 69.5 0.7 6e-19 68.0 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA21573.1 - 7.6e-05 22.5 5.5 0.00015 21.5 0.1 3.4 3 1 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA21573.1 - 0.00085 18.5 0.2 0.0014 17.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Cep57_MT_bd PF06657.8 ESA21577.1 - 0.059 13.3 0.3 0.16 11.9 0.2 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 SUZ-C PF12901.2 ESA21577.1 - 0.069 12.7 1.6 0.19 11.4 1.1 1.7 1 0 0 1 1 1 0 SUZ-C motif RVT_1 PF00078.22 ESA21578.1 - 0.00012 21.4 0.0 0.22 10.8 0.0 2.4 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Dimer_Tnp_hAT PF05699.9 ESA21579.1 - 0.031 13.8 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region NDUFB10 PF10249.4 ESA21580.1 - 0.076 13.1 2.3 0.11 12.6 1.5 1.4 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 Cellulase PF00150.13 ESA21581.1 - 1.4e-22 80.2 7.0 1.1e-11 44.4 2.3 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.14 ESA21581.1 - 0.0026 17.1 0.1 0.0047 16.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Palm_thioest PF02089.10 ESA21582.1 - 2.4e-72 243.2 0.2 2.8e-72 243.0 0.1 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.15 ESA21582.1 - 2.6e-06 27.1 0.0 3.5e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.6 ESA21582.1 - 0.0065 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DCAF15_WD40 PF14939.1 ESA21582.1 - 0.04 13.2 0.0 0.068 12.5 0.0 1.3 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat Ribosomal_L19e PF01280.15 ESA21583.1 - 3.9e-64 214.8 11.5 3.9e-64 214.8 8.0 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e Actin PF00022.14 ESA21584.1 - 1.6e-91 306.6 0.0 1.9e-91 306.4 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 ESA21584.1 - 0.0002 20.0 0.0 0.00073 18.2 0.0 1.8 1 1 0 1 1 1 1 MreB/Mbl protein PNP_UDP_1 PF01048.15 ESA21585.1 - 4.2e-44 150.2 0.0 5e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Bot1p PF12298.3 ESA21586.1 - 5.4e-33 114.3 0.5 9.3e-33 113.5 0.3 1.4 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein DUF2316 PF10078.4 ESA21586.1 - 0.0045 16.9 0.8 0.22 11.5 0.0 2.7 2 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2316) MBOAT PF03062.14 ESA21587.1 - 1e-12 47.8 1.3 1e-12 47.8 0.9 1.8 1 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family SecD_SecF PF02355.11 ESA21587.1 - 0.13 11.4 0.8 0.19 10.9 0.1 1.5 2 0 0 2 2 2 0 Protein export membrane protein Pkinase_Tyr PF07714.12 ESA21588.1 - 0.00081 18.5 0.1 0.0018 17.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21588.1 - 0.042 13.0 0.1 0.17 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain DUF822 PF05687.8 ESA21588.1 - 0.093 13.0 0.2 12 6.2 0.1 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF822) SNAP PF14938.1 ESA21590.1 - 4.1e-38 131.1 5.4 4.8e-38 130.9 3.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 ESA21590.1 - 0.00041 20.2 4.3 0.014 15.2 0.1 2.5 2 1 1 3 3 3 2 Tetratricopeptide repeat Spatacsin_C PF14649.1 ESA21590.1 - 0.0089 14.9 0.3 0.012 14.5 0.2 1.1 1 0 0 1 1 1 1 Spatacsin C-terminus TPR_7 PF13176.1 ESA21590.1 - 0.016 14.9 2.5 1.8 8.5 0.0 4.2 5 1 0 5 5 5 0 Tetratricopeptide repeat PRD_Mga PF08270.6 ESA21590.1 - 0.041 13.1 1.6 0.69 9.1 0.2 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) PRD domain TPR_14 PF13428.1 ESA21590.1 - 0.052 14.2 1.5 1.2e+02 3.7 0.1 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA21590.1 - 0.13 12.2 3.1 25 5.1 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA21590.1 - 0.13 11.9 4.8 14 5.4 0.0 3.5 2 1 2 4 4 4 0 TPR repeat TPR_6 PF13174.1 ESA21590.1 - 0.16 12.5 4.7 9.3 6.9 0.3 4.6 5 1 1 6 6 6 0 Tetratricopeptide repeat Tmemb_14 PF03647.8 ESA21591.1 - 8.9e-21 74.1 5.7 1e-20 73.9 3.9 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF3792 PF12670.2 ESA21591.1 - 1.9 8.3 7.7 20 5.0 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3792) zf-UBR PF02207.15 ESA21592.1 - 1.2e-16 60.2 14.4 1.2e-16 60.2 10.0 3.0 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 ESA21592.1 - 7.3e-13 48.0 0.1 1.9e-12 46.7 0.1 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PulS_OutS PF09691.5 ESA21593.1 - 0.029 14.3 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial chaperone lipoprotein (PulS_OutS) UPF0160 PF03690.8 ESA21594.1 - 0.018 14.4 0.0 0.26 10.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0160) zf-Sec23_Sec24 PF04810.10 ESA21594.1 - 0.56 9.8 4.0 0.3 10.6 0.2 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger LptC PF06835.8 ESA21595.1 - 0.004 16.5 0.2 0.0093 15.3 0.1 1.7 1 1 1 2 2 2 1 Lipopolysaccharide-assembly, LptC-related zf-Sec23_Sec24 PF04810.10 ESA21596.1 - 0.072 12.6 0.4 0.13 11.8 0.3 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger BTB PF00651.26 ESA21597.1 - 1.7e-16 60.1 0.2 3.2e-16 59.2 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21597.1 - 6.1e-13 48.9 2.0 1.8e-12 47.4 1.4 1.9 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA21597.1 - 0.00039 20.2 1.0 0.0019 18.0 0.4 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF4130 PF13566.1 ESA21597.1 - 0.0092 15.5 0.8 0.15 11.6 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4130 BTB PF00651.26 ESA21598.1 - 8e-15 54.7 0.1 1.7e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21598.1 - 1.1e-08 35.1 0.7 3.2e-08 33.6 0.5 1.8 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA21598.1 - 0.00023 20.9 4.7 0.00087 19.1 1.3 2.8 1 1 2 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA21599.1 - 9.5e-16 57.7 0.9 7.7e-15 54.8 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA21599.1 - 6.1e-11 42.4 0.2 1.3e-10 41.4 0.2 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA21599.1 - 0.43 10.4 4.4 2.1 8.2 1.4 3.0 1 1 2 3 3 3 0 BTB And C-terminal Kelch Peptidase_A17 PF05380.8 ESA21601.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Pao retrotransposon peptidase TPMT PF05724.6 ESA21602.1 - 3.3e-41 141.1 0.0 4.1e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.1 ESA21602.1 - 1.6e-09 37.5 0.0 2.1e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA21602.1 - 1.1e-08 35.4 0.0 1.6e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA21602.1 - 2.5e-08 34.2 0.0 3.5e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA21602.1 - 4.8e-07 30.1 0.0 7.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA21602.1 - 3.2e-06 26.9 0.0 3.6e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA21602.1 - 1.1e-05 25.9 0.0 1.6e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 ESA21602.1 - 9.8e-05 21.5 0.0 0.00012 21.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 ESA21602.1 - 0.048 13.3 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF4177 PF13783.1 ESA21602.1 - 0.091 12.4 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) PCI PF01399.22 ESA21605.1 - 1.2e-22 80.1 2.8 4.2e-22 78.4 0.6 2.4 2 0 0 2 2 2 1 PCI domain PCI_Csn8 PF10075.4 ESA21605.1 - 3.1e-13 49.6 0.3 7.9e-13 48.3 0.2 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 TPR_12 PF13424.1 ESA21605.1 - 0.001 18.9 3.6 0.099 12.5 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 ESA21605.1 - 0.049 13.2 1.6 0.26 10.9 0.9 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA21605.1 - 0.068 12.8 0.2 0.33 10.6 0.1 2.3 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.1 ESA21605.1 - 0.1 12.4 7.4 0.54 10.1 0.1 4.8 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA21605.1 - 0.12 12.3 0.6 2.3 8.3 0.5 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4400 PF14348.1 ESA21605.1 - 0.14 11.5 0.1 0.33 10.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) DUF3688 PF12461.3 ESA21605.1 - 9 6.7 8.5 38 4.7 2.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3688) Med20 PF08612.6 ESA21607.1 - 0.032 13.3 0.0 0.052 12.6 0.0 1.3 1 1 0 1 1 1 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Syntaxin-18_N PF10496.4 ESA21607.1 - 0.64 9.9 4.9 14 5.5 1.1 2.5 2 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Xpo1 PF08389.7 ESA21608.1 - 2.8e-20 72.7 7.8 2.1e-18 66.6 1.8 3.9 3 1 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.14 ESA21608.1 - 1.2e-07 31.5 4.5 2.1e-07 30.7 0.3 3.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain CRM1_C PF08767.6 ESA21608.1 - 0.0052 15.7 0.1 0.037 12.9 0.0 2.4 2 0 0 2 2 2 1 CRM1 C terminal Bromodomain PF00439.20 ESA21609.1 - 2.2e-51 171.7 1.6 3.6e-25 87.6 0.1 3.0 3 1 0 3 3 3 2 Bromodomain DUF2654 PF10849.3 ESA21609.1 - 0.025 14.3 0.0 0.079 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) MGC-24 PF05283.6 ESA21609.1 - 0.043 13.5 1.1 0.092 12.5 0.8 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) TSA PF03249.8 ESA21610.1 - 1.4 7.3 8.6 3.2 6.1 5.9 1.5 1 0 0 1 1 1 0 Type specific antigen tRNA_edit PF04073.10 ESA21611.1 - 0.00019 21.2 0.0 0.00056 19.7 0.0 1.7 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain PIF1 PF05970.9 ESA21612.1 - 5.4e-15 55.2 3.1 2.9e-09 36.3 0.1 2.6 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 ESA21612.1 - 3.6e-05 23.4 0.0 0.003 17.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 ESA21612.1 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain CDC45 PF02724.9 ESA21613.1 - 0.038 12.0 6.2 0.044 11.8 4.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.6 ESA21613.1 - 0.12 12.2 8.6 0.17 11.7 6.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TLP-20 PF06088.6 ESA21613.1 - 0.32 10.6 6.0 0.14 11.8 2.1 1.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) F-box-like PF12937.2 ESA21615.1 - 0.00036 20.1 0.2 0.00059 19.5 0.1 1.3 1 0 0 1 1 1 1 F-box-like Thoc2 PF11732.3 ESA21615.1 - 0.0021 17.8 0.7 0.02 14.6 0.1 2.0 2 0 0 2 2 2 1 Transcription- and export-related complex subunit AAA_23 PF13476.1 ESA21616.1 - 0.83 9.9 9.0 1.1 9.5 6.2 1.3 1 1 0 1 1 1 0 AAA domain Rpr2 PF04032.11 ESA21617.1 - 6.8e-22 77.1 4.5 2.1e-21 75.5 3.1 1.7 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain ELFV_dehydrog PF00208.16 ESA21618.1 - 9.5e-55 185.8 0.0 2.6e-54 184.3 0.0 1.7 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 ESA21618.1 - 1.9e-23 82.0 0.0 1.9e-14 52.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 ESA21618.1 - 0.002 17.7 0.0 0.0066 16.0 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain HTH_29 PF13551.1 ESA21618.1 - 0.035 14.2 0.1 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix MFS_1 PF07690.11 ESA21619.1 - 7.7e-38 130.1 30.6 1.2e-37 129.4 21.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA21619.1 - 2.3e-34 118.7 28.3 1.9e-22 79.5 5.7 2.3 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.2 ESA21619.1 - 2.9e-06 26.9 7.3 0.014 15.1 0.2 2.8 2 0 0 2 2 2 2 MFS_1 like family DUF373 PF04123.8 ESA21619.1 - 6.2 5.7 9.1 0.55 9.1 2.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF373) 3D PF06725.6 ESA21620.1 - 0.0021 18.0 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 3D domain Pkinase PF00069.20 ESA21621.1 - 1.9e-31 109.1 0.9 2.1e-31 109.0 0.2 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21621.1 - 2.3e-31 108.7 0.0 3.4e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA21622.1 - 1.7e-28 99.4 0.1 2.7e-28 98.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21622.1 - 2.5e-24 85.8 4.7 6.6e-23 81.1 3.3 2.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA21622.1 - 0.19 11.4 0.1 0.3 10.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Stc1 PF12898.2 ESA21622.1 - 0.72 9.9 11.6 3.5 7.7 2.9 2.8 1 1 1 2 2 2 0 Stc1 domain mIF3 PF14877.1 ESA21624.1 - 0.087 12.1 0.3 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial translation initiation factor MARVEL PF01284.18 ESA21625.1 - 1.7e-07 31.1 7.2 2.6e-07 30.5 5.0 1.3 1 0 0 1 1 1 1 Membrane-associating domain OPT PF03169.10 ESA21625.1 - 0.0066 14.9 5.3 0.01 14.3 2.4 1.8 2 0 0 2 2 2 1 OPT oligopeptide transporter protein DUF1600 PF07667.6 ESA21625.1 - 0.013 15.5 5.4 0.013 15.5 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1600) Fig1 PF12351.3 ESA21625.1 - 0.019 14.8 7.4 2.2 8.1 2.7 2.5 1 1 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 DUF1385 PF07136.6 ESA21625.1 - 0.072 12.1 2.9 0.14 11.2 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) FTZ PF03867.9 ESA21625.1 - 0.089 12.0 0.5 0.12 11.5 0.0 1.4 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Voltage_CLC PF00654.15 ESA21625.1 - 0.14 11.1 4.6 0.2 10.6 3.2 1.1 1 0 0 1 1 1 0 Voltage gated chloride channel Claudin_3 PF06653.6 ESA21625.1 - 2.4 7.8 15.0 55 3.4 8.5 2.7 2 1 0 2 2 2 0 Tight junction protein, Claudin-like DUF4064 PF13273.1 ESA21625.1 - 5 7.3 15.4 2.5 8.2 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SAM_1 PF00536.25 ESA21627.1 - 4e-05 23.7 0.0 5.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 ESA21627.1 - 0.007 16.1 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) AF-4 PF05110.8 ESA21628.1 - 5.4 4.7 7.7 7.4 4.2 5.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Hepatitis_core PF00906.15 ESA21629.1 - 0.034 13.8 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 Hepatitis core antigen DASH_Dad4 PF08650.5 ESA21629.1 - 0.2 11.6 1.2 1.2 9.0 0.0 2.1 1 1 1 2 2 2 0 DASH complex subunit Dad4 AAA_22 PF13401.1 ESA21630.1 - 0.0021 18.1 0.0 0.093 12.8 0.0 2.8 1 1 0 1 1 1 1 AAA domain LRR_4 PF12799.2 ESA21630.1 - 0.12 12.0 1.3 0.53 9.9 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Orbi_NS3 PF01616.11 ESA21630.1 - 0.19 10.6 0.2 0.46 9.4 0.1 1.6 1 0 0 1 1 1 0 Orbivirus NS3 EF-hand_1 PF00036.27 ESA21630.1 - 0.19 11.1 2.3 11 5.5 0.0 3.4 3 0 0 3 3 3 0 EF hand HMG_box PF00505.14 ESA21631.1 - 3.6e-11 43.1 0.1 5.4e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA21631.1 - 0.0043 17.3 0.1 0.0063 16.8 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain Pkinase_Tyr PF07714.12 ESA21632.1 - 8.8e-33 113.4 0.0 1.3e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21632.1 - 6.4e-26 91.0 0.0 8.1e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ycf54 PF10674.4 ESA21634.1 - 0.046 13.8 0.1 0.052 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) Sel1 PF08238.7 ESA21635.1 - 2.4e-44 148.7 10.3 5.5e-06 26.8 0.0 8.3 8 0 0 8 8 8 8 Sel1 repeat TPR_6 PF13174.1 ESA21635.1 - 0.009 16.4 6.9 21 5.8 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21635.1 - 0.012 15.5 2.6 6.2 6.8 0.2 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF1100 PF06500.6 ESA21635.1 - 0.048 12.2 1.3 0.05 12.1 0.1 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1100) PPR_2 PF13041.1 ESA21635.1 - 0.069 13.1 2.8 1.5 8.8 0.0 3.9 4 1 1 5 5 5 0 PPR repeat family PPR PF01535.15 ESA21635.1 - 0.096 12.7 6.7 22 5.2 0.1 5.8 6 0 0 6 6 6 0 PPR repeat Ribosomal_S21 PF01165.15 ESA21635.1 - 0.52 9.7 2.6 1.6 8.2 0.1 2.9 3 0 0 3 3 3 0 Ribosomal protein S21 TPR_11 PF13414.1 ESA21635.1 - 2 8.1 16.2 0.7 9.5 0.7 4.0 2 2 2 4 4 4 0 TPR repeat Sel1 PF08238.7 ESA21636.1 - 2.8e-40 135.8 13.4 2.8e-05 24.5 0.0 7.4 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.1 ESA21636.1 - 0.0068 16.7 6.3 15 6.2 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat Dimer_Tnp_Tn5 PF02281.11 ESA21636.1 - 0.046 13.8 0.7 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Transposase Tn5 dimerisation domain LRR_4 PF12799.2 ESA21639.1 - 1.2e-06 27.9 0.4 0.00048 19.6 0.1 2.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA21639.1 - 0.00015 21.4 0.6 0.00067 19.3 0.1 1.9 1 1 1 2 2 2 1 Leucine rich repeat LRR_6 PF13516.1 ESA21639.1 - 0.00042 20.1 0.1 0.024 14.6 0.0 2.3 1 1 1 2 2 2 2 Leucine Rich repeat LRR_1 PF00560.28 ESA21639.1 - 0.046 13.7 0.1 0.27 11.4 0.1 2.3 1 1 0 1 1 1 0 Leucine Rich Repeat LRR_5 PF13306.1 ESA21639.1 - 0.1 12.2 0.0 0.11 12.1 0.0 1.0 1 0 0 1 1 1 0 Leucine rich repeats (6 copies) LRR_7 PF13504.1 ESA21639.1 - 0.28 11.5 1.2 14 6.3 0.0 2.9 2 2 0 2 2 2 0 Leucine rich repeat MalF_P2 PF14785.1 ESA21640.1 - 0.084 12.7 0.2 0.5 10.2 0.0 2.0 1 1 1 2 2 2 0 Maltose transport system permease protein MalF P2 domain Ubiquitin_2 PF14560.1 ESA21640.1 - 0.67 10.2 3.3 0.64 10.3 0.7 2.1 3 0 0 3 3 3 0 Ubiquitin-like domain GpcrRhopsn4 PF10192.4 ESA21641.1 - 0.00022 20.5 1.7 0.00025 20.3 1.2 1.0 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain DUF2232 PF09991.4 ESA21641.1 - 0.015 14.2 1.8 0.015 14.2 1.2 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2232) Yip1 PF04893.12 ESA21641.1 - 0.035 13.5 4.6 0.053 13.0 3.2 1.2 1 0 0 1 1 1 0 Yip1 domain PMP22_Claudin PF00822.15 ESA21641.1 - 0.049 13.2 3.0 0.062 12.9 2.1 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family ATP-synt_C PF00137.16 ESA21641.1 - 0.12 12.3 5.6 0.89 9.5 0.6 2.1 2 0 0 2 2 2 0 ATP synthase subunit C DUF1282 PF06930.7 ESA21641.1 - 0.13 11.9 5.9 0.17 11.5 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) RNase_H PF00075.19 ESA21642.1 - 2.1e-06 28.1 0.0 2.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 RNase H Rep_3 PF01051.16 ESA21642.1 - 0.027 14.0 0.1 0.032 13.8 0.1 1.1 1 0 0 1 1 1 0 Initiator Replication protein DNA_pol3_a_NII PF11490.3 ESA21642.1 - 0.053 13.1 0.1 0.064 12.8 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Phage_integrase PF00589.17 ESA21645.1 - 0.0011 18.7 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family CDC45 PF02724.9 ESA21645.1 - 0.31 9.0 4.4 0.4 8.6 3.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Hint PF01079.15 ESA21646.1 - 2.9e-16 59.3 0.0 4.1e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Hint module AIG1 PF04548.11 ESA21647.1 - 4e-21 75.1 0.1 4e-21 75.1 0.1 2.9 1 1 2 3 3 3 1 AIG1 family MMR_HSR1 PF01926.18 ESA21647.1 - 0.00047 20.1 1.6 0.001 18.9 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA21647.1 - 0.02 14.7 0.0 0.02 14.7 0.0 4.0 2 1 0 2 2 2 0 Dynamin family SPC25 PF06703.6 ESA21648.1 - 0.087 12.4 0.2 0.087 12.4 0.1 1.0 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4253 PF14062.1 ESA21651.1 - 0.19 11.3 1.4 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4253) LRR_7 PF13504.1 ESA21651.1 - 0.58 10.5 2.9 38 5.1 0.1 3.9 2 0 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.28 ESA21651.1 - 2.8 8.3 8.1 17 5.9 0.7 4.7 3 0 0 3 3 3 0 Leucine Rich Repeat Choline_transpo PF04515.7 ESA21653.1 - 2.9e-55 187.3 20.0 2.9e-55 187.3 13.8 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter TLP-20 PF06088.6 ESA21656.1 - 0.0022 17.6 5.5 0.0026 17.4 3.8 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF3169 PF11368.3 ESA21656.1 - 0.012 14.8 0.6 0.012 14.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Z1 PF10593.4 ESA21656.1 - 0.089 11.9 0.4 0.093 11.9 0.3 1.0 1 0 0 1 1 1 0 Z1 domain PI31_Prot_N PF11566.3 ESA21658.1 - 0.029 13.9 1.3 0.044 13.3 0.9 1.3 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal BTB PF00651.26 ESA21660.1 - 1.2e-17 63.8 0.1 2.6e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21660.1 - 8.8e-11 41.9 0.4 2.1e-10 40.7 0.1 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA21660.1 - 3e-07 30.2 2.4 3.3e-06 26.8 0.1 3.1 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA21660.1 - 0.0015 17.7 0.7 0.0021 17.2 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Pkinase_Tyr PF07714.12 ESA21661.1 - 0.00017 20.7 0.0 0.00023 20.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21661.1 - 0.029 13.5 0.7 0.14 11.2 0.5 1.9 1 1 0 1 1 1 0 Protein kinase domain DUF2439 PF10382.4 ESA21661.1 - 0.21 11.8 3.4 0.17 12.1 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) Arch_ATPase PF01637.13 ESA21662.1 - 1.9e-09 37.6 4.0 8.2e-05 22.4 0.1 2.6 1 1 1 2 2 2 2 Archaeal ATPase AAA PF00004.24 ESA21662.1 - 3.8e-08 33.6 0.0 7.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA21662.1 - 2.3e-05 24.5 2.2 0.0057 16.7 0.3 2.8 2 1 1 3 3 3 1 AAA domain AAA_14 PF13173.1 ESA21662.1 - 3.4e-05 23.7 2.5 4.6e-05 23.3 0.1 2.3 1 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA21662.1 - 8.8e-05 22.6 0.5 0.006 16.7 0.0 2.8 2 0 0 2 2 2 1 RNA helicase Bac_DnaA PF00308.13 ESA21662.1 - 0.00014 21.6 0.4 0.00026 20.7 0.3 1.5 1 0 0 1 1 1 1 Bacterial dnaA protein cobW PF02492.14 ESA21662.1 - 0.00023 20.6 0.0 0.0004 19.8 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 ESA21662.1 - 0.00037 20.5 0.0 0.0052 16.7 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain NB-ARC PF00931.17 ESA21662.1 - 0.0017 17.2 3.2 0.0078 15.1 0.1 2.6 1 1 1 2 2 2 1 NB-ARC domain AAA_24 PF13479.1 ESA21662.1 - 0.007 15.9 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA21662.1 - 0.0088 16.8 4.0 0.027 15.2 1.9 2.5 2 1 0 2 2 1 1 AAA domain UPF0146 PF03686.8 ESA21662.1 - 0.029 14.1 0.3 0.058 13.2 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) KAP_NTPase PF07693.9 ESA21662.1 - 0.036 13.0 0.1 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF815 PF05673.8 ESA21662.1 - 0.037 12.9 0.0 0.094 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NTPase_1 PF03266.10 ESA21662.1 - 0.044 13.4 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 NTPase NACHT PF05729.7 ESA21662.1 - 0.048 13.3 0.2 0.1 12.2 0.1 1.7 1 1 0 1 1 1 0 NACHT domain DUF835 PF05763.7 ESA21662.1 - 0.051 13.1 1.8 0.4 10.2 0.1 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF835) ATP-synt_ab PF00006.20 ESA21662.1 - 0.065 12.7 0.2 0.12 11.8 0.1 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain VirE PF05272.6 ESA21662.1 - 0.068 12.6 2.0 0.51 9.7 0.0 2.5 2 1 0 2 2 2 0 Virulence-associated protein E KaiC PF06745.8 ESA21662.1 - 0.076 12.1 0.7 0.15 11.1 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.1 ESA21662.1 - 0.16 11.5 0.4 0.3 10.6 0.3 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 ESA21662.1 - 0.82 9.9 4.7 0.38 11.0 0.2 2.6 2 2 0 2 2 2 0 AAA domain Methyltransf_11 PF08241.7 ESA21664.1 - 5.2e-13 49.3 0.0 9.1e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA21664.1 - 2.6e-12 46.9 0.0 5.8e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA21664.1 - 3.3e-09 36.6 0.0 9.4e-09 35.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA21664.1 - 5.7e-09 35.7 0.0 1.5e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA21664.1 - 3.7e-06 27.3 0.0 8.4e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA21664.1 - 1.4e-05 25.6 0.0 3.6e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 ESA21664.1 - 3.1e-05 23.4 0.0 5.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.13 ESA21664.1 - 0.00017 20.7 0.0 0.00058 19.0 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 ESA21664.1 - 0.0076 15.3 0.0 0.021 13.8 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_29 PF03141.11 ESA21664.1 - 0.016 13.6 0.0 0.41 8.9 0.0 2.0 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TehB PF03848.9 ESA21664.1 - 0.02 14.0 0.0 0.047 12.8 0.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_26 PF13659.1 ESA21664.1 - 0.027 14.5 0.0 0.061 13.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Mga PF05043.8 ESA21664.1 - 0.084 13.1 2.3 0.096 12.9 0.2 2.1 2 0 0 2 2 2 0 Mga helix-turn-helix domain Fe_hyd_lg_C PF02906.9 ESA21665.1 - 1.6e-85 286.8 0.0 3.8e-85 285.5 0.0 1.6 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.12 ESA21665.1 - 1.1e-06 28.5 0.2 2.6e-06 27.3 0.1 1.7 1 0 0 1 1 1 1 Iron hydrogenase small subunit Myb_DNA-bind_6 PF13921.1 ESA21666.1 - 9.2e-07 28.8 14.8 0.013 15.5 0.0 4.2 3 1 1 4 4 4 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA21666.1 - 0.0017 18.3 9.2 0.11 12.5 0.1 4.0 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA21666.1 - 0.027 15.0 1.6 0.027 15.0 1.1 3.3 1 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA21667.1 - 0.00012 22.0 0.7 0.051 13.6 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA21667.1 - 0.002 18.1 2.3 0.042 13.9 0.1 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_3 PF12776.2 ESA21667.1 - 0.0023 18.5 1.0 0.042 14.4 0.0 2.2 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain GST_N_3 PF13417.1 ESA21668.1 - 1.4e-14 54.0 0.0 2.6e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA21668.1 - 7.5e-14 51.4 0.0 1.4e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA21668.1 - 3.2e-12 46.4 0.0 5.5e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA21668.1 - 1.8e-09 37.4 0.0 3.8e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA21668.1 - 4.3e-08 32.9 0.0 7.5e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF3899 PF13038.1 ESA21669.1 - 0.025 14.7 0.5 0.028 14.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Shugoshin_N PF07558.6 ESA21670.1 - 8.1e-05 22.2 11.0 0.0032 17.1 2.5 3.6 3 0 0 3 3 3 1 Shugoshin N-terminal coiled-coil region TSC22 PF01166.13 ESA21670.1 - 0.0017 18.2 4.4 0.0017 18.2 3.0 3.3 1 1 0 2 2 2 1 TSC-22/dip/bun family bZIP_1 PF00170.16 ESA21670.1 - 0.028 14.3 3.6 0.028 14.3 2.5 3.4 2 1 2 4 4 4 0 bZIP transcription factor Choline_kin_N PF04428.9 ESA21670.1 - 0.097 12.1 0.1 0.32 10.5 0.1 1.9 1 0 0 1 1 1 0 Choline kinase N terminus DUF904 PF06005.7 ESA21670.1 - 0.11 12.7 18.6 0.26 11.6 1.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF904) DUF972 PF06156.8 ESA21670.1 - 0.14 12.5 17.2 0.45 10.8 2.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF972) NYD-SP28_assoc PF14775.1 ESA21670.1 - 0.28 10.9 13.3 1.1 9.0 2.3 3.5 2 1 1 3 3 3 0 Sperm tail C-terminal domain GAGA_bind PF06217.7 ESA21670.1 - 0.75 9.7 6.6 0.93 9.4 4.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family HALZ PF02183.13 ESA21670.1 - 0.83 9.4 7.7 3.8 7.3 1.9 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF1635 PF07795.6 ESA21670.1 - 0.83 8.9 10.3 0.17 11.2 4.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) HlyD PF00529.15 ESA21670.1 - 2 7.6 8.3 2.8 7.1 5.7 1.2 1 0 0 1 1 1 0 HlyD family secretion protein IFP_35_N PF07334.8 ESA21670.1 - 2.6 8.0 5.5 1.5 8.8 1.0 2.7 2 1 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DivIC PF04977.10 ESA21670.1 - 3.7 7.0 18.2 0.091 12.2 3.3 2.9 2 1 0 3 3 3 0 Septum formation initiator DUF2216 PF10226.4 ESA21670.1 - 4.3 6.7 11.4 9.7 5.6 5.6 3.0 2 1 0 2 2 2 0 Uncharacterized conserved proteins (DUF2216) NMT_C PF02799.10 ESA21672.1 - 0.01 15.2 0.5 0.015 14.7 0.4 1.4 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain HNOB PF07700.10 ESA21672.1 - 0.09 12.2 0.4 0.24 10.9 0.0 1.9 2 0 0 2 2 2 0 Heme NO binding Rox3 PF08633.5 ESA21673.1 - 0.19 12.0 8.0 0.32 11.2 5.5 1.4 1 1 0 1 1 1 0 Rox3 mediator complex subunit TSC22 PF01166.13 ESA21673.1 - 1.3 9.0 14.2 0.93 9.5 1.1 3.1 1 1 2 3 3 3 0 TSC-22/dip/bun family DUF2968 PF11180.3 ESA21673.1 - 5.8 6.2 13.3 2.4 7.4 2.7 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF2968) RFX5_DNA_bdg PF14621.1 ESA21676.1 - 0.91 9.0 3.9 1.4 8.4 2.7 1.2 1 0 0 1 1 1 0 RFX5 DNA-binding domain DUF1713 PF08213.6 ESA21678.1 - 1.5e-10 40.4 22.2 1.5e-10 40.4 15.4 1.6 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) ICAP-1_inte_bdg PF10480.4 ESA21678.1 - 0.0036 17.1 0.3 0.0042 16.8 0.2 1.0 1 0 0 1 1 1 1 Beta-1 integrin binding protein HGTP_anticodon2 PF12745.2 ESA21678.1 - 0.069 12.2 8.9 0.077 12.1 6.2 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs DUF1690 PF07956.6 ESA21678.1 - 0.076 12.9 12.8 0.088 12.7 8.9 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF1819 PF08849.6 ESA21678.1 - 0.16 11.3 5.0 0.17 11.2 3.1 1.3 1 1 0 1 1 1 0 Putative inner membrane protein (DUF1819) TBPIP PF07106.8 ESA21678.1 - 0.9 9.0 13.8 1 8.9 9.5 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FRG1 PF06229.7 ESA21678.1 - 1.4 8.3 9.9 1.6 8.1 6.9 1.0 1 0 0 1 1 1 0 FRG1-like family DUF3435 PF11917.3 ESA21678.1 - 1.4 7.5 8.4 1.7 7.2 5.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) PMSI1 PF15322.1 ESA21678.1 - 1.5 7.8 4.9 1.7 7.6 3.4 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DivIC PF04977.10 ESA21678.1 - 9.4 5.8 15.9 1.2 8.6 1.7 2.3 1 1 1 2 2 2 0 Septum formation initiator MoaC PF01967.16 ESA21679.1 - 1.7e-52 176.6 3.5 2.9e-52 175.9 2.4 1.4 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.8 ESA21679.1 - 5.1e-38 129.6 0.0 1e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.16 ESA21679.1 - 1.2e-26 93.8 0.0 1.9e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 ESA21679.1 - 1.5e-08 34.8 0.0 3.6e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 ESA21679.1 - 1.4e-07 31.5 0.0 3.3e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Ribosomal_L1 PF00687.16 ESA21680.1 - 3.2e-60 203.2 2.9 3.2e-60 203.2 2.0 2.7 2 1 0 2 2 2 1 Ribosomal protein L1p/L10e family WBS_methylT PF12589.3 ESA21681.1 - 7.7e-19 67.9 7.0 1.2e-18 67.4 4.9 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 ESA21681.1 - 7.8e-11 42.3 0.0 1.5e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA21681.1 - 1.2e-06 28.2 0.0 1.9e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA21681.1 - 6.4e-06 26.5 0.1 2.7e-05 24.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA21681.1 - 8.4e-06 25.5 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA21681.1 - 1.7e-05 25.0 0.0 4.6e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA21681.1 - 4.8e-05 23.8 0.0 9.1e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA21681.1 - 0.0062 16.5 0.0 0.014 15.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.8 ESA21681.1 - 0.011 15.8 0.0 0.031 14.3 0.0 1.7 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase PrmA PF06325.8 ESA21681.1 - 0.032 13.3 0.3 0.19 10.7 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.7 ESA21681.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF1168 PF06658.7 ESA21682.1 - 3.6e-26 91.3 2.5 4e-26 91.2 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) Proteasome PF00227.21 ESA21683.1 - 7e-48 162.4 0.5 7.9e-48 162.2 0.4 1.0 1 0 0 1 1 1 1 Proteasome subunit TRAPPC9-Trs120 PF08626.6 ESA21684.1 - 3.2e-203 677.3 0.1 4.2e-203 676.9 0.1 1.2 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.2 ESA21684.1 - 0.058 12.0 0.0 0.092 11.3 0.0 1.3 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Mg_trans_NIPA PF05653.9 ESA21685.1 - 1e-28 100.1 17.5 2.8e-26 92.1 11.3 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 ESA21685.1 - 9.6e-05 22.5 1.6 9.6e-05 22.5 1.1 3.7 2 1 2 4 4 4 1 Multidrug resistance efflux transporter EamA PF00892.15 ESA21685.1 - 0.0054 16.7 2.6 0.0054 16.7 1.8 3.4 3 1 1 4 4 4 2 EamA-like transporter family DUF4064 PF13273.1 ESA21685.1 - 0.012 15.7 6.3 0.012 15.7 4.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) CaKB PF03185.10 ESA21685.1 - 0.024 14.0 0.7 1 8.7 0.1 2.7 2 0 0 2 2 2 0 Calcium-activated potassium channel, beta subunit Shisa PF13908.1 ESA21685.1 - 0.28 11.3 1.4 0.48 10.5 0.1 2.0 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Colicin PF01024.14 ESA21685.1 - 4.2 6.9 8.2 1.7 8.2 0.4 3.0 3 0 0 3 3 3 0 Colicin pore forming domain BTB PF00651.26 ESA21686.1 - 2.7e-20 72.4 0.0 5e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21686.1 - 2.1e-11 43.9 1.6 4.2e-11 43.0 1.1 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA21686.1 - 0.0016 18.2 3.1 0.0028 17.4 0.3 2.8 3 1 1 4 4 4 1 BTB And C-terminal Kelch TNV_CP PF03898.8 ESA21686.1 - 0.044 12.8 0.0 0.08 11.9 0.0 1.3 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein DUF2151 PF10221.4 ESA21687.1 - 0.031 12.4 4.0 0.03 12.5 2.8 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Apt1 PF10351.4 ESA21687.1 - 0.1 11.4 7.9 0.14 11.0 5.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain GNT-I PF03071.10 ESA21687.1 - 0.11 10.9 1.4 0.12 10.8 1.0 1.2 1 0 0 1 1 1 0 GNT-I family TMPIT PF07851.8 ESA21687.1 - 0.43 9.5 8.7 0.54 9.2 6.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein CDC45 PF02724.9 ESA21687.1 - 0.56 8.1 9.7 0.61 8.0 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein OmpH PF03938.9 ESA21687.1 - 0.56 10.1 9.3 0.66 9.9 6.5 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vfa1 PF08432.5 ESA21687.1 - 0.63 10.0 11.5 0.84 9.6 8.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 eIF-3_zeta PF05091.7 ESA21687.1 - 0.65 8.5 9.1 0.81 8.2 6.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GAGA_bind PF06217.7 ESA21687.1 - 1.7 8.5 10.2 2.1 8.2 7.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family YqfQ PF14181.1 ESA21687.1 - 3.7 7.5 9.6 6 6.8 6.7 1.4 1 0 0 1 1 1 0 YqfQ-like protein DUF3449 PF11931.3 ESA21687.1 - 4 6.9 12.8 6.1 6.2 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) PA26 PF04636.8 ESA21687.1 - 5.3 5.6 9.0 7 5.2 6.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GBP_C PF02841.9 ESA21687.1 - 5.8 6.0 21.4 9.2 5.3 14.8 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain AIG1 PF04548.11 ESA21688.1 - 4.9e-19 68.2 0.3 5.7e-19 68.0 0.2 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA21688.1 - 9.2e-06 25.6 0.1 9.7e-06 25.5 0.1 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA21688.1 - 0.0064 16.3 0.1 0.0068 16.2 0.1 1.1 1 0 0 1 1 1 1 Dynamin family Resolvase PF00239.16 ESA21688.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Resolvase, N terminal domain FeoB_N PF02421.13 ESA21688.1 - 0.13 11.5 0.1 0.15 11.2 0.0 1.3 1 1 0 1 1 1 0 Ferrous iron transport protein B TLD PF07534.11 ESA21689.1 - 2.5e-12 46.9 3.4 3.9e-12 46.3 2.3 1.3 1 0 0 1 1 1 1 TLD RasGEF_N PF00618.15 ESA21689.1 - 0.17 11.9 1.6 0.51 10.4 1.1 1.8 1 1 0 1 1 1 0 RasGEF N-terminal motif TLD PF07534.11 ESA21690.1 - 1.4e-16 60.7 2.8 3.4e-16 59.4 1.9 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA21690.1 - 4.9e-12 45.8 0.0 1.2e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21690.1 - 0.00045 20.0 5.0 0.001 18.8 0.5 3.5 4 1 1 5 5 5 1 BTB And C-terminal Kelch p450 PF00067.17 ESA21691.1 - 1.4e-43 149.1 6.1 9e-42 143.1 4.2 2.1 1 1 0 1 1 1 1 Cytochrome P450 Inhibitor_I67 PF11405.3 ESA21691.1 - 0.058 13.4 0.2 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Bromelain inhibitor VI Tubulin PF00091.20 ESA21693.1 - 2.4e-70 236.7 0.0 3.6e-70 236.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 ESA21693.1 - 9.8e-49 164.5 0.0 1.6e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 ESA21693.1 - 7.3e-06 26.0 0.2 1.7e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 ESA21693.1 - 0.002 17.6 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain BACK PF07707.10 ESA21695.1 - 0.013 15.3 0.2 0.019 14.7 0.2 1.5 1 1 0 1 1 1 0 BTB And C-terminal Kelch UQ_con PF00179.21 ESA21696.1 - 7.2e-52 174.5 0.0 8.1e-52 174.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA21696.1 - 6.4e-05 22.7 0.0 7.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 ESA21696.1 - 0.0047 16.7 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 ESA21696.1 - 0.022 14.4 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 UEV domain Sec66 PF09802.4 ESA21697.1 - 9.1e-41 139.3 2.9 1.7e-40 138.4 2.0 1.5 1 1 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF1682 PF07946.9 ESA21697.1 - 0.58 8.9 24.3 0.85 8.4 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) GAGA_bind PF06217.7 ESA21697.1 - 2.7 7.8 12.1 3.2 7.6 8.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Neur_chan_memb PF02932.11 ESA21697.1 - 9.4 6.0 8.4 43 3.8 5.8 1.9 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CTDII PF01556.13 ESA21698.1 - 1.4e-26 92.2 5.3 6.1e-21 74.1 0.1 3.4 3 1 0 3 3 3 2 DnaJ C terminal domain DnaJ PF00226.26 ESA21698.1 - 1.2e-25 89.0 6.0 1.9e-25 88.3 4.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 ESA21698.1 - 3.5e-11 42.9 19.6 7.1e-11 41.9 13.6 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 ESA21698.1 - 0.006 16.2 9.9 0.24 11.0 1.2 2.4 1 1 1 2 2 2 2 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 ESA21698.1 - 2.5 8.1 12.5 0.3 11.0 0.5 3.4 2 1 1 3 3 3 0 Zinc ribbon domain Hydrolase_6 PF13344.1 ESA21699.1 - 6.2e-16 58.1 0.0 1.1e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 ESA21699.1 - 3.5e-10 39.4 0.1 2.9e-09 36.5 0.0 2.4 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.21 ESA21699.1 - 9.1e-07 29.5 0.0 0.00021 21.7 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA21699.1 - 9e-05 22.7 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Fimbrial_CS1 PF04449.7 ESA21700.1 - 0.0029 17.6 0.4 0.0051 16.8 0.2 1.5 1 1 1 2 2 2 1 CS1 type fimbrial major subunit CPSF100_C PF13299.1 ESA21701.1 - 1.5e-31 109.7 0.1 2.3e-26 92.8 0.0 2.6 1 1 1 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 ESA21701.1 - 6e-27 94.0 0.0 1.7e-26 92.6 0.0 1.8 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 ESA21701.1 - 0.00033 20.3 0.0 0.00065 19.4 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 ESA21701.1 - 0.0033 17.1 0.0 0.0068 16.2 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Mito_carr PF00153.22 ESA21702.1 - 1.3e-22 79.2 0.0 2.3e-09 36.8 0.0 4.7 3 2 0 3 3 3 3 Mitochondrial carrier protein NUDIX PF00293.23 ESA21703.1 - 4.6e-11 42.4 0.1 8.3e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Protocadherin PF08374.6 ESA21704.1 - 0.0027 17.4 0.0 0.0036 16.9 0.0 1.1 1 0 0 1 1 1 1 Protocadherin PgaD PF13994.1 ESA21704.1 - 0.03 13.8 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 PgaD-like protein Mid2 PF04478.7 ESA21704.1 - 0.079 12.3 0.1 0.079 12.3 0.1 2.1 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Rax2 PF12768.2 ESA21704.1 - 0.11 11.6 0.3 0.21 10.7 0.0 1.6 2 0 0 2 2 2 0 Cortical protein marker for cell polarity Amnionless PF14828.1 ESA21704.1 - 0.16 10.3 0.0 0.19 10.1 0.0 1.1 1 0 0 1 1 1 0 Amnionless Vpu PF00558.14 ESA21704.1 - 1.3 8.6 7.4 12 5.5 5.1 2.1 1 1 0 1 1 1 0 Vpu protein ABC2_membrane_3 PF12698.2 ESA21704.1 - 1.4 7.8 4.7 1.1 8.2 1.0 2.2 2 1 0 2 2 2 0 ABC-2 family transporter protein DUF3827 PF12877.2 ESA21704.1 - 4.9 5.1 7.7 0.33 8.9 1.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3827) Dimer_Tnp_hAT PF05699.9 ESA21708.1 - 8.3e-11 41.3 0.2 8.9e-11 41.2 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region HMG_box PF00505.14 ESA21709.1 - 7.5e-05 22.9 0.2 0.0002 21.5 0.1 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA21709.1 - 0.0023 18.2 0.1 0.0042 17.4 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain G-7-MTase PF12803.2 ESA21709.1 - 0.0066 15.6 1.0 0.008 15.3 0.7 1.2 1 0 0 1 1 1 1 mRNA (guanine-7-)methyltransferase (G-7-MTase) KIAA1430 PF13879.1 ESA21709.1 - 2.3 8.6 6.8 2.6 8.5 1.5 3.0 1 1 1 2 2 2 0 KIAA1430 homologue HMG_box PF00505.14 ESA21710.1 - 8.5e-05 22.7 0.5 0.00015 21.9 0.3 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA21710.1 - 0.003 17.8 0.2 0.0052 17.1 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain eIF-6 PF01912.13 ESA21711.1 - 6e-85 283.3 0.5 7.5e-85 283.0 0.3 1.1 1 0 0 1 1 1 1 eIF-6 family Ribosomal_S3_C PF00189.15 ESA21712.1 - 4.4e-07 30.0 1.6 1.1e-06 28.6 1.1 1.8 1 1 0 1 1 1 1 Ribosomal protein S3, C-terminal domain VAR1 PF05316.7 ESA21712.1 - 7.2e-05 21.5 4.2 7.2e-05 21.5 2.9 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) Mito_carr PF00153.22 ESA21713.1 - 2.4e-71 235.5 0.4 4.3e-25 87.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-Nse PF11789.3 ESA21714.1 - 5.1e-05 22.7 0.1 0.00012 21.4 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SCF PF02404.10 ESA21714.1 - 0.00018 20.8 0.9 0.00021 20.5 0.6 1.1 1 0 0 1 1 1 1 Stem cell factor V_ATPase_I PF01496.14 ESA21714.1 - 0.24 9.1 3.9 0.27 9.0 2.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnd1 PF12717.2 ESA21715.1 - 1.7e-66 223.4 12.1 6.6e-61 205.2 2.3 4.3 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 ESA21715.1 - 7.3e-42 142.8 1.1 7.3e-42 142.8 0.8 3.4 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.1 ESA21715.1 - 3.9e-08 33.4 0.0 0.01 16.1 0.0 5.5 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.17 ESA21715.1 - 1e-05 25.2 0.2 0.23 11.6 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat DUF2435 PF10363.4 ESA21715.1 - 0.00013 21.7 0.2 2.3 8.2 0.0 4.3 3 1 1 4 4 4 2 Protein of unknown function (DUF2435) HEAT_EZ PF13513.1 ESA21715.1 - 0.0011 19.3 0.1 19 5.9 0.0 4.8 5 0 0 5 5 5 0 HEAT-like repeat Cohesin_HEAT PF12765.2 ESA21715.1 - 0.065 13.2 0.2 2.5 8.1 0.1 3.4 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Dak2 PF02734.12 ESA21715.1 - 0.14 11.8 1.3 0.52 9.9 0.9 2.0 1 0 0 1 1 1 0 DAK2 domain DUF1840 PF08895.6 ESA21715.1 - 1.6 8.7 6.6 1.5 8.8 1.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) RNA_pol_L_2 PF13656.1 ESA21716.1 - 1.1e-29 101.6 0.0 1.4e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 ESA21716.1 - 4.5e-12 44.9 0.0 6.2e-12 44.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Mito_carr PF00153.22 ESA21717.1 - 7.2e-76 250.0 1.0 2.8e-25 87.8 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein TPR_14 PF13428.1 ESA21718.1 - 1.8e-09 37.3 1.7 0.026 15.1 0.3 4.8 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA21718.1 - 1.5e-08 34.1 6.2 0.0008 19.0 0.6 2.8 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.1 ESA21718.1 - 2.9e-07 30.7 7.3 0.0036 17.5 4.5 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA21718.1 - 2.5e-06 27.9 2.3 0.29 11.8 0.8 3.7 1 1 2 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESA21718.1 - 5.6e-05 22.3 1.5 8e-05 21.8 1.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 ESA21718.1 - 9.4e-05 22.1 2.0 0.046 13.5 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat ChAPs PF09295.5 ESA21718.1 - 0.0018 17.1 0.4 0.0024 16.6 0.3 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_6 PF13174.1 ESA21718.1 - 0.0022 18.3 2.5 8.5 7.0 0.3 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21718.1 - 0.014 15.3 10.0 0.025 14.5 1.7 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3808 PF10300.4 ESA21718.1 - 0.016 13.7 0.0 0.028 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_2 PF07719.12 ESA21718.1 - 0.05 13.5 7.8 36 4.6 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA21718.1 - 0.26 10.9 3.5 4.7 6.9 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA21718.1 - 0.51 10.2 9.7 27 4.8 0.3 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA21718.1 - 0.52 10.6 5.1 3.5 8.0 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat Ribosomal_S10 PF00338.17 ESA21719.1 - 6e-33 112.5 0.3 7e-33 112.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e WD40 PF00400.27 ESA21720.1 - 5.3e-12 45.1 2.8 8.4e-09 34.9 0.4 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat F-box-like PF12937.2 ESA21720.1 - 1.7e-09 37.2 3.9 3.7e-09 36.1 1.8 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA21720.1 - 8.1e-06 25.3 0.8 2.1e-05 24.0 0.5 1.7 1 0 0 1 1 1 1 F-box domain DUF2462 PF09495.5 ESA21721.1 - 3.9e-12 46.7 13.8 3.9e-12 46.7 9.6 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) DUF4049 PF13258.1 ESA21721.1 - 0.36 9.7 2.4 0.43 9.4 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4049) Cpn60_TCP1 PF00118.19 ESA21722.1 - 1.2e-143 479.2 7.1 1.4e-143 479.1 4.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sigma70_r1_1 PF03979.9 ESA21722.1 - 0.069 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 PRMT5 PF05185.11 ESA21723.1 - 4.4e-08 32.4 0.0 7.4e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_18 PF12847.2 ESA21723.1 - 2.4e-07 31.2 0.0 4.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 ESA21723.1 - 1.2e-06 27.8 0.1 1.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESA21723.1 - 1.6e-05 24.8 0.0 5.2e-05 23.2 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA21723.1 - 0.00015 21.5 0.0 0.00046 19.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 ESA21723.1 - 0.0027 17.1 0.2 0.0051 16.2 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 ESA21723.1 - 0.0056 17.1 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA21723.1 - 0.048 13.2 0.0 0.21 11.1 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 ESA21723.1 - 0.05 12.9 0.0 0.076 12.4 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.1 ESA21723.1 - 0.068 13.5 0.0 1 9.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain DREV PF05219.7 ESA21723.1 - 0.096 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase BTB PF00651.26 ESA21724.1 - 8.3e-10 38.6 0.0 2.3e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21724.1 - 4.2e-06 26.5 1.5 7.2e-05 22.5 0.9 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA21725.1 - 2.2e-11 43.9 4.4 1.5e-10 41.2 1.7 2.4 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA21725.1 - 8.4e-11 41.8 0.0 1.8e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21725.1 - 6.6e-05 22.6 3.2 0.00018 21.2 0.8 2.6 1 1 2 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA21726.1 - 1.4e-16 60.4 0.0 3.2e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21726.1 - 4.7e-05 23.1 1.7 0.00061 19.5 0.5 2.9 1 1 2 3 3 3 1 BTB And C-terminal Kelch FlaC_arch PF05377.6 ESA21727.1 - 0.021 14.7 1.3 0.053 13.4 0.9 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF948 PF06103.6 ESA21727.1 - 0.069 13.0 0.2 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4083 PF13314.1 ESA21727.1 - 0.075 12.8 0.4 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DUF904 PF06005.7 ESA21727.1 - 0.29 11.4 2.4 1 9.6 1.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF904) TLD PF07534.11 ESA21728.1 - 6.2e-19 68.3 0.4 8e-19 68.0 0.2 1.1 1 0 0 1 1 1 1 TLD Pkinase_Tyr PF07714.12 ESA21729.1 - 2.3e-31 108.8 0.0 4.5e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21729.1 - 1.4e-29 103.0 0.0 3.1e-29 101.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA21729.1 - 0.012 15.3 0.3 0.017 14.8 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 ESA21729.1 - 0.051 12.6 0.9 0.087 11.8 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA21730.1 - 0.084 11.9 0.9 0.54 9.2 0.1 2.2 1 1 0 2 2 2 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA21731.1 - 2e-15 56.5 0.0 3.5e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21731.1 - 3.6e-08 32.8 0.0 6.7e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Glyco_trans_1_2 PF13524.1 ESA21732.1 - 0.0091 16.2 0.0 0.0092 16.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3785 PF12653.2 ESA21732.1 - 0.051 13.4 1.3 0.059 13.2 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3785) DUF3712 PF12505.3 ESA21733.1 - 8.4e-39 132.4 29.4 2.1e-18 66.5 0.9 5.6 6 0 0 6 6 6 3 Protein of unknown function (DUF3712) LEA_2 PF03168.8 ESA21733.1 - 2.9e-18 66.0 16.1 0.00014 22.1 0.5 6.3 6 0 0 6 6 6 5 Late embryogenesis abundant protein F-box-like PF12937.2 ESA21734.1 - 9.3e-05 22.0 0.0 0.00023 20.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.8 ESA21734.1 - 0.4 11.2 13.8 1.2 9.7 0.2 6.5 6 1 1 7 7 7 0 Leucine Rich Repeat Pkinase PF00069.20 ESA21735.1 - 2.3e-35 122.0 0.3 4.2e-35 121.1 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21735.1 - 4e-35 121.1 0.0 5.3e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA21735.1 - 0.0043 16.8 0.0 0.0078 15.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DBD_Tnp_Hermes PF10683.4 ESA21736.1 - 0.04 13.3 0.0 0.068 12.6 0.0 1.5 1 0 0 1 1 1 0 Hermes transposase DNA-binding domain TLD PF07534.11 ESA21741.1 - 1.1e-12 48.1 2.0 1.7e-12 47.5 0.3 2.0 2 0 0 2 2 2 1 TLD Fimbrial_CS1 PF04449.7 ESA21743.1 - 0.071 13.1 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 CS1 type fimbrial major subunit HTH_29 PF13551.1 ESA21743.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_S10 PF00450.17 ESA21744.1 - 1.5e-69 235.1 0.2 1.9e-69 234.8 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Sec1 PF00995.18 ESA21744.1 - 0.032 12.8 1.4 0.054 12.1 1.0 1.3 1 0 0 1 1 1 0 Sec1 family BatD PF13584.1 ESA21744.1 - 0.097 11.2 0.0 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Herpes_gE PF02480.11 ESA21744.1 - 0.11 10.6 0.0 0.18 10.0 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Arc_PepC PF06819.6 ESA21745.1 - 0.12 12.2 3.9 0.073 12.9 1.1 1.7 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain DUF1343 PF07075.6 ESA21745.1 - 0.3 9.9 1.5 0.34 9.6 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1343) Nbs1_C PF08599.5 ESA21746.1 - 1.1 9.2 3.9 2.2 8.2 0.7 2.6 2 1 1 3 3 3 0 DNA damage repair protein Nbs1 Pkinase_Tyr PF07714.12 ESA21747.1 - 4.8e-35 120.8 0.0 8.2e-35 120.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21747.1 - 2.4e-33 115.4 0.0 4.7e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF1542 PF07564.6 ESA21747.1 - 0.0013 18.7 0.6 0.0013 18.7 0.4 2.9 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1542) Kdo PF06293.9 ESA21747.1 - 0.038 13.0 0.0 0.066 12.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA21747.1 - 0.046 13.4 0.3 0.074 12.7 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3839 PF12943.2 ESA21749.1 - 0.048 12.8 0.3 0.094 11.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3839) Methyltransf_11 PF08241.7 ESA21750.1 - 2.4e-12 47.1 0.0 5.2e-12 46.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA21750.1 - 3e-11 43.1 0.0 3.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA21750.1 - 4.8e-11 43.2 0.0 7e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA21750.1 - 2.5e-06 27.8 0.0 3.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA21750.1 - 9.3e-06 25.9 0.0 1.8e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 ESA21750.1 - 2.3e-05 23.8 0.0 5.5e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.1 ESA21750.1 - 3.3e-05 23.6 0.0 0.00011 22.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA21750.1 - 8.1e-05 21.8 0.2 0.043 12.9 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family TPMT PF05724.6 ESA21750.1 - 0.0065 15.9 0.0 0.013 14.9 0.0 1.5 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) MTS PF05175.9 ESA21750.1 - 0.068 12.5 0.0 0.16 11.2 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Transcrip_act PF04949.8 ESA21750.1 - 0.092 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator Methyltransf_32 PF13679.1 ESA21750.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Med4 PF10018.4 ESA21751.1 - 1.8e-29 102.4 5.8 2.5e-29 102.0 4.0 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Cob_adeno_trans PF01923.13 ESA21751.1 - 0.0069 16.1 0.3 0.012 15.4 0.2 1.3 1 0 0 1 1 1 1 Cobalamin adenosyltransferase MCPsignal PF00015.16 ESA21751.1 - 0.011 15.2 1.3 0.022 14.3 0.9 1.5 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Myc_N PF01056.13 ESA21751.1 - 0.017 14.2 0.7 0.024 13.8 0.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Mgr1 PF08602.5 ESA21751.1 - 0.04 12.9 0.6 0.062 12.3 0.4 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit TRADD_N PF09034.5 ESA21751.1 - 0.041 13.8 1.6 0.078 12.9 0.8 1.7 1 1 0 1 1 1 0 TRADD, N-terminal domain PilM PF07419.7 ESA21751.1 - 0.042 13.3 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 PilM LAT PF15234.1 ESA21751.1 - 0.046 13.1 3.4 0.065 12.7 2.4 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DUF4611 PF15387.1 ESA21751.1 - 0.073 13.2 6.3 0.091 12.9 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF2540 PF10802.3 ESA21751.1 - 0.16 11.6 4.6 0.16 11.6 1.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2540) Ly49 PF08391.5 ESA21751.1 - 0.2 11.7 1.0 0.36 10.9 0.7 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF2890 PF11081.3 ESA21751.1 - 1.1 9.2 7.9 0.19 11.7 2.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) Histone PF00125.19 ESA21752.1 - 4.6e-24 84.3 0.0 6.5e-24 83.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 ESA21752.1 - 0.00029 20.8 0.0 0.00049 20.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1849 PF08904.6 ESA21752.1 - 0.069 12.4 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1849) CoA_binding_2 PF13380.1 ESA21753.1 - 4.9e-31 107.3 0.0 5.8e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 ESA21753.1 - 5.7e-06 26.7 0.0 7.5e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain LANC_like PF05147.8 ESA21754.1 - 2.7e-47 161.0 2.3 3.4e-47 160.7 1.6 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein LNS2 PF08235.8 ESA21757.1 - 5.5e-71 237.2 0.0 9.4e-71 236.4 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 ESA21757.1 - 2.4e-40 136.6 0.0 6.5e-40 135.2 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region AF1Q PF15017.1 ESA21757.1 - 0.045 13.6 0.1 0.045 13.6 0.1 4.2 4 0 0 4 4 4 0 Drug resistance and apoptosis regulator PEMT PF04191.8 ESA21758.1 - 7.2e-30 103.2 5.2 7.2e-30 103.2 3.6 1.8 3 0 0 3 3 3 1 Phospholipid methyltransferase SNARE_assoc PF09335.6 ESA21758.1 - 0.016 15.4 2.6 0.016 15.3 0.2 2.0 2 1 0 2 2 2 0 SNARE associated Golgi protein DUF3708 PF12501.3 ESA21758.1 - 0.24 11.2 1.5 2.8 7.7 1.8 1.9 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter UCH PF00443.24 ESA21759.1 - 2.3e-46 158.0 0.0 3e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA21759.1 - 2.4e-16 60.0 0.0 3.6e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.1 ESA21759.1 - 2.9e-05 23.5 1.1 1 8.5 0.1 3.8 4 0 0 4 4 4 3 Ubiquitin-specific peptidase-like, SUMO isopeptidase YtxH PF12732.2 ESA21760.1 - 0.038 14.3 2.7 0.29 11.5 1.8 2.4 1 1 0 1 1 1 0 YtxH-like protein vATP-synt_E PF01991.13 ESA21760.1 - 0.52 9.5 6.0 0.4 9.9 2.4 1.9 1 1 1 2 2 2 0 ATP synthase (E/31 kDa) subunit LEA_4 PF02987.11 ESA21760.1 - 0.65 9.9 13.2 0.67 9.8 3.9 2.4 1 1 1 2 2 2 0 Late embryogenesis abundant protein RRM_1 PF00076.17 ESA21761.1 - 2.8e-11 42.8 0.1 5.1e-11 42.0 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA21761.1 - 4.9e-10 39.2 0.1 7.9e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA21761.1 - 1.5e-08 34.3 0.1 3e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA21761.1 - 0.00067 19.4 0.1 0.0016 18.2 0.1 1.6 1 0 0 1 1 1 1 RNA binding motif zf-CCCH_2 PF14608.1 ESA21761.1 - 0.0013 18.6 1.2 0.0045 16.9 0.8 2.0 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type Calcipressin PF04847.7 ESA21761.1 - 0.0028 17.2 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 Calcipressin zf-CCCH PF00642.19 ESA21761.1 - 0.016 14.9 2.0 0.016 14.9 1.4 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FYVE PF01363.16 ESA21761.1 - 0.026 14.4 0.3 0.026 14.4 0.2 1.9 3 0 0 3 3 3 0 FYVE zinc finger DUF2392 PF10288.4 ESA21763.1 - 1.4 9.3 4.2 3.3 8.0 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2392) NAD_binding_1 PF00175.16 ESA21765.1 - 7e-20 71.6 0.0 9.9e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 ESA21765.1 - 3.2e-07 30.3 0.1 7.9e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 ESA21765.1 - 0.00021 21.2 0.0 0.015 15.1 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain An_peroxidase PF03098.10 ESA21767.1 - 8.5e-67 225.7 0.0 1.2e-66 225.2 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase DOMON PF03351.12 ESA21767.1 - 1.3e-12 47.7 0.1 3.9e-12 46.1 0.0 1.9 2 0 0 2 2 2 1 DOMON domain Cytochrom_B561 PF03188.11 ESA21767.1 - 1.3e-06 28.2 9.0 2.5e-06 27.3 6.2 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.4 ESA21767.1 - 1.9 8.1 7.2 2.4 7.7 2.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2427) Sel1 PF08238.7 ESA21768.1 - 4.6e-12 46.1 3.8 3.7e-06 27.3 0.0 3.5 3 0 0 3 3 3 2 Sel1 repeat Pkinase_Tyr PF07714.12 ESA21768.1 - 1.2e-09 37.6 0.0 2.4e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21768.1 - 6.9e-07 28.6 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TPR_16 PF13432.1 ESA21768.1 - 0.00087 19.8 0.5 0.04 14.5 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 ESA21768.1 - 0.021 15.1 3.3 0.07 13.4 0.0 3.2 2 2 1 3 3 3 0 Tetratricopeptide repeat Rep_fac_C PF08542.6 ESA21768.1 - 0.092 12.7 0.0 4.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Replication factor C C-terminal domain DDE_1 PF03184.14 ESA21770.1 - 4.4e-09 35.7 0.2 1.5e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA21770.1 - 0.0016 18.2 0.3 0.0034 17.1 0.1 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DUF3140 PF11338.3 ESA21770.1 - 0.037 14.1 0.1 0.065 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) Hydantoinase_B PF02538.9 ESA21771.1 - 0.11 10.6 0.5 0.63 8.1 0.0 1.8 1 1 1 2 2 2 0 Hydantoinase B/oxoprolinase zf-BED PF02892.10 ESA21773.1 - 0.0013 18.4 3.9 0.0061 16.2 0.3 2.6 2 0 0 2 2 2 1 BED zinc finger zf-C2H2 PF00096.21 ESA21774.1 - 0.012 15.8 0.9 0.071 13.4 0.6 2.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA21774.1 - 0.04 14.2 0.5 0.04 14.2 0.3 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger dTMP_synthase PF02593.9 ESA21774.1 - 0.095 12.0 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Thymidylate synthase Orbi_VP5 PF00901.12 ESA21774.1 - 0.098 10.8 0.2 0.11 10.6 0.1 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 zf-C2H2_jaz PF12171.3 ESA21774.1 - 5.3 7.3 10.4 2.4 8.4 1.1 4.1 5 1 0 5 5 5 0 Zinc-finger double-stranded RNA-binding WD40 PF00400.27 ESA21775.1 - 3.7e-91 296.0 39.9 2.2e-10 40.0 0.0 11.8 12 0 0 12 12 12 11 WD domain, G-beta repeat Utp13 PF08625.6 ESA21775.1 - 3e-50 169.5 2.3 5.1e-50 168.7 1.6 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nucleoporin_N PF08801.6 ESA21775.1 - 1.2e-07 30.8 17.2 0.019 13.7 0.1 5.6 1 1 4 5 5 5 3 Nup133 N terminal like Nup160 PF11715.3 ESA21775.1 - 5.4e-06 24.8 9.4 0.64 8.0 0.0 6.5 3 3 4 7 7 7 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 ESA21775.1 - 0.00013 20.3 0.1 0.0019 16.5 0.0 2.6 1 1 0 2 2 2 1 Cytochrome D1 heme domain PQQ_2 PF13360.1 ESA21775.1 - 0.0018 17.8 0.1 4 6.8 0.0 3.4 2 1 0 2 2 2 2 PQQ-like domain YABBY PF04690.8 ESA21776.1 - 2e-09 37.9 0.1 2.2e-09 37.7 0.1 1.1 1 0 0 1 1 1 1 YABBY protein DUF1014 PF06244.7 ESA21776.1 - 2.1e-06 27.9 1.2 2.3e-06 27.8 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) HMG_box PF00505.14 ESA21776.1 - 8.1e-05 22.8 0.6 0.00011 22.4 0.4 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA21776.1 - 0.0006 20.1 0.1 0.00078 19.7 0.1 1.2 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.7 ESA21776.1 - 0.016 14.8 1.2 0.022 14.4 0.8 1.2 1 0 0 1 1 1 0 CHDNT (NUC034) domain p450 PF00067.17 ESA21777.1 - 4.6e-77 259.4 2.8 6.2e-77 259.0 1.9 1.1 1 0 0 1 1 1 1 Cytochrome P450 Archease PF01951.11 ESA21777.1 - 0.0094 15.8 0.3 0.051 13.5 0.2 2.2 1 1 0 1 1 1 1 Archease protein family (MTH1598/TM1083) GDPD PF03009.12 ESA21778.1 - 3.5e-38 131.5 0.0 6.5e-38 130.6 0.0 1.5 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 ESA21778.1 - 6.8e-06 26.1 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family p450 PF00067.17 ESA21779.1 - 2.3e-65 220.9 3.7 4.4e-65 220.0 2.6 1.3 1 1 0 1 1 1 1 Cytochrome P450 NPHI_C PF08469.5 ESA21779.1 - 0.029 14.2 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal zf-C2H2 PF00096.21 ESA21780.1 - 6.4e-10 38.7 7.7 9.8e-05 22.4 0.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA21780.1 - 9.4e-07 28.7 5.9 0.034 14.4 0.1 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA21780.1 - 0.0014 18.7 0.4 0.0014 18.7 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain DUF976 PF06162.7 ESA21780.1 - 0.0077 15.7 0.6 0.016 14.7 0.4 1.4 1 0 0 1 1 1 1 Caenorhabditis elegans protein of unknown function (DUF976) Rota_VP2 PF05087.7 ESA21780.1 - 0.059 11.2 0.0 0.069 11.0 0.0 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein zf-H2C2_2 PF13465.1 ESA21781.1 - 3.4e-32 109.1 38.3 3.1e-08 33.4 0.6 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.21 ESA21781.1 - 2.6e-22 77.7 34.9 8.8e-06 25.7 0.7 5.2 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA21781.1 - 5.2e-13 48.3 28.5 0.0049 17.1 0.4 5.2 5 0 0 5 5 5 5 C2H2-type zinc finger Ogr_Delta PF04606.7 ESA21781.1 - 0.0007 19.2 7.4 0.39 10.3 0.1 4.5 2 1 2 4 4 4 2 Ogr/Delta-like zinc finger zf-tcix PF14952.1 ESA21781.1 - 0.0053 16.0 2.6 5.7 6.3 0.0 4.1 4 0 0 4 4 4 1 Putative treble-clef, zinc-finger, Zn-binding CHORD PF04968.7 ESA21781.1 - 0.017 15.3 23.7 1.4 9.1 0.5 5.3 1 1 4 5 5 5 0 CHORD Not1 PF04054.10 ESA21781.1 - 0.026 13.4 1.4 0.031 13.1 1.0 1.1 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 Rubrerythrin PF02915.12 ESA21786.1 - 0.0043 17.3 0.1 0.01 16.1 0.0 1.6 1 1 1 2 2 2 1 Rubrerythrin TLD PF07534.11 ESA21787.1 - 1.4e-12 47.7 1.8 1.8e-12 47.4 1.2 1.1 1 0 0 1 1 1 1 TLD Kelch_4 PF13418.1 ESA21791.1 - 9.6e-15 54.0 10.5 0.00023 20.8 0.5 4.7 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA21791.1 - 9.2e-10 38.2 6.5 0.13 12.3 0.0 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 ESA21791.1 - 1.4e-09 37.7 11.7 0.043 13.9 0.0 4.9 2 2 2 4 4 4 4 Kelch motif Kelch_3 PF13415.1 ESA21791.1 - 2.5e-09 37.0 8.3 2.3e-05 24.4 0.2 4.6 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA21791.1 - 7.5e-08 31.8 2.3 0.12 12.2 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 ESA21791.1 - 2.5e-07 30.1 13.5 0.0031 17.0 0.0 4.1 4 1 0 4 4 4 2 Kelch motif Laminin_G_3 PF13385.1 ESA21792.1 - 2.3e-22 79.9 1.0 3.2e-10 40.4 0.1 2.1 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Toxin_R_bind_N PF07953.7 ESA21792.1 - 1.1e-06 28.3 4.4 0.012 15.1 0.2 2.5 2 0 0 2 2 2 2 Clostridium neurotoxin, N-terminal receptor binding DUF402 PF04167.8 ESA21792.1 - 0.044 13.6 3.2 5.6 6.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF402) DUF1838 PF08894.6 ESA21793.1 - 0.0092 15.2 0.1 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1838) BTB PF00651.26 ESA21794.1 - 5e-13 49.0 0.1 1.3e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA21795.1 - 2.6e-15 56.3 0.5 7.7e-15 54.8 0.4 1.9 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.2 ESA21796.1 - 1.4e-23 83.0 0.6 2.8e-10 40.3 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 ESA21796.1 - 4.1e-23 80.8 0.5 3.9e-09 36.4 0.1 3.6 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 ESA21796.1 - 1e-22 78.7 1.0 3.5e-07 29.7 0.0 5.6 5 1 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 ESA21796.1 - 2.2e-20 72.5 1.3 2.3e-09 37.5 0.1 4.5 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA21796.1 - 3.5e-17 60.7 0.5 7e-05 22.6 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat DEAD PF00270.24 ESA21797.1 - 1.4e-42 145.1 0.7 1.7e-41 141.5 0.1 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.1 ESA21797.1 - 2.5e-23 81.3 0.0 5.5e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 ESA21797.1 - 1.7e-05 24.7 0.0 1.7e-05 24.7 0.0 3.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 ESA21797.1 - 0.00013 21.7 1.6 0.0037 17.0 0.0 2.7 1 1 1 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 ESA21797.1 - 0.00055 18.8 0.8 0.017 13.9 0.0 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain DUF4137 PF13593.1 ESA21797.1 - 0.054 12.6 0.0 0.074 12.1 0.0 1.2 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) S10_plectin PF03501.10 ESA21798.1 - 2e-44 149.3 0.1 2.4e-44 149.1 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain G10 PF01125.12 ESA21799.1 - 7.3e-67 223.4 3.3 7.3e-67 223.4 2.3 1.6 2 0 0 2 2 2 1 G10 protein DUF2072 PF09845.4 ESA21799.1 - 6.7 6.6 10.2 5.1 7.0 4.4 2.0 2 0 0 2 2 2 0 Zn-ribbon containing protein (DUF2072) Pkinase_Tyr PF07714.12 ESA21801.1 - 2.7e-31 108.5 0.0 3.2e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21801.1 - 6.5e-24 84.4 0.0 8.1e-24 84.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF2645 PF10840.3 ESA21802.1 - 0.054 13.6 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2645) MetJ PF01340.15 ESA21802.1 - 0.1 12.3 0.1 1.7 8.4 0.1 2.2 1 1 0 1 1 1 0 Met Apo-repressor, MetJ HisKA PF00512.20 ESA21803.1 - 0.061 13.3 0.0 0.081 12.9 0.0 1.2 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain DUF4014 PF13198.1 ESA21804.1 - 3.5 8.0 7.0 3 8.3 0.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF4014) LRR_2 PF07723.8 ESA21807.1 - 0.097 13.2 0.5 4.9 7.8 0.5 2.2 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_1 PF00560.28 ESA21807.1 - 0.18 11.9 0.4 0.98 9.7 0.0 2.2 2 1 0 2 2 2 0 Leucine Rich Repeat TLD PF07534.11 ESA21808.1 - 9.2e-13 48.3 1.9 1.3e-12 47.8 1.3 1.3 1 0 0 1 1 1 1 TLD Peptidase_S46 PF10459.4 ESA21809.1 - 0.011 14.2 4.8 0.0077 14.7 2.5 1.3 1 1 0 1 1 1 0 Peptidase S46 Gp58 PF07902.6 ESA21809.1 - 0.036 12.2 4.6 0.043 12.0 3.2 1.1 1 0 0 1 1 1 0 gp58-like protein DUF4527 PF15030.1 ESA21809.1 - 0.093 12.0 4.9 0.083 12.1 2.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4527) DUF1664 PF07889.7 ESA21809.1 - 0.11 12.2 8.5 1.6 8.5 4.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Lebercilin PF15619.1 ESA21809.1 - 0.22 10.9 24.6 2.1 7.6 0.1 3.2 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease AAA_13 PF13166.1 ESA21809.1 - 0.25 9.7 20.5 0.37 9.1 7.5 2.0 1 1 1 2 2 2 0 AAA domain XhlA PF10779.4 ESA21809.1 - 0.48 10.3 9.0 0.32 10.9 1.1 2.7 2 1 0 2 2 2 0 Haemolysin XhlA FliD_N PF02465.13 ESA21809.1 - 1.3 9.4 9.4 2.1 8.7 5.2 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4407 PF14362.1 ESA21809.1 - 1.4 7.7 13.4 2.5 6.9 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.7 ESA21809.1 - 1.6 8.4 25.5 0.4 10.4 2.4 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ADIP PF11559.3 ESA21809.1 - 2.3 8.0 18.6 1.4 8.7 7.4 2.5 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding VIT1 PF01988.14 ESA21809.1 - 2.9 7.3 5.1 27 4.1 1.5 2.1 2 0 0 2 2 2 0 VIT family Spc7 PF08317.6 ESA21809.1 - 4.9 5.7 21.3 0.31 9.6 3.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein zf-C4H2 PF10146.4 ESA21809.1 - 6.8 6.6 19.0 14 5.6 6.6 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein ATG16 PF08614.6 ESA21809.1 - 7.1 6.3 21.7 0.37 10.6 7.6 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF724 PF05266.9 ESA21809.1 - 7.2 6.1 17.3 0.54 9.8 5.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF724) FlpD PF02662.11 ESA21810.1 - 0.15 11.7 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit F-box-like PF12937.2 ESA21811.1 - 5e-05 22.9 1.8 6.2e-05 22.6 0.3 1.9 2 0 0 2 2 2 1 F-box-like TLD PF07534.11 ESA21814.1 - 4.3e-11 42.9 0.4 1.2e-10 41.5 0.2 1.9 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA21815.1 - 2.3e-17 62.9 0.0 4.4e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA21815.1 - 4.7e-17 62.2 8.4 1e-09 38.4 0.4 3.3 3 0 0 3 3 3 2 TLD BACK PF07707.10 ESA21815.1 - 4.3e-11 42.5 4.2 7.9e-08 32.0 0.2 3.8 3 1 1 4 4 4 3 BTB And C-terminal Kelch Hint PF01079.15 ESA21816.1 - 7.1e-10 38.4 0.0 8.2e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.1 ESA21816.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.4 1 1 0 1 1 1 0 Hint domain AIG1 PF04548.11 ESA21817.1 - 5e-32 110.7 0.2 6.9e-32 110.2 0.1 1.2 1 0 0 1 1 1 1 AIG1 family Hint PF01079.15 ESA21817.1 - 4.4e-26 91.4 0.0 8.5e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Hint module MMR_HSR1 PF01926.18 ESA21817.1 - 7.6e-12 45.2 0.0 1.4e-11 44.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 ESA21817.1 - 1.5e-07 31.3 1.6 0.0046 16.7 0.1 2.7 2 1 1 3 3 2 2 Dynamin family DUF258 PF03193.11 ESA21817.1 - 6.1e-07 28.7 0.0 1.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 ESA21817.1 - 1.1e-05 25.8 0.7 0.00035 20.8 0.0 2.4 2 1 0 2 2 2 1 ABC transporter FeoB_N PF02421.13 ESA21817.1 - 0.00076 18.7 0.0 0.0013 18.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.1 ESA21817.1 - 0.001 19.3 1.3 0.0033 17.7 0.1 2.3 1 1 2 3 3 3 1 AAA domain Gtr1_RagA PF04670.7 ESA21817.1 - 0.0011 18.2 0.1 0.0019 17.4 0.1 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA21817.1 - 0.0014 19.0 0.0 0.0039 17.6 0.0 1.8 1 1 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 ESA21817.1 - 0.003 16.8 0.6 0.0064 15.7 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.17 ESA21817.1 - 0.0092 14.8 0.1 1.7 7.4 0.0 2.3 1 1 0 2 2 2 1 NB-ARC domain AAA_10 PF12846.2 ESA21817.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Zeta_toxin PF06414.7 ESA21817.1 - 0.01 14.9 0.2 0.041 12.9 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.1 ESA21817.1 - 0.012 15.0 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SE PF00437.15 ESA21817.1 - 0.013 14.4 0.0 0.023 13.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_17 PF13207.1 ESA21817.1 - 0.014 16.2 0.5 0.063 14.0 0.3 2.5 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA21817.1 - 0.014 15.2 0.0 0.043 13.7 0.0 2.0 2 1 0 2 2 1 0 AAA domain PduV-EutP PF10662.4 ESA21817.1 - 0.018 14.5 0.7 0.075 12.5 0.5 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.1 ESA21817.1 - 0.034 14.1 0.0 0.063 13.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activ_2 PF14532.1 ESA21817.1 - 0.045 13.7 0.1 1.2 9.1 0.1 2.5 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.24 ESA21817.1 - 0.047 13.8 0.3 0.17 12.0 0.1 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 ESA21817.1 - 0.047 13.8 0.1 0.12 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 ESA21817.1 - 0.058 13.5 0.0 0.27 11.4 0.0 2.2 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.12 ESA21817.1 - 0.075 12.8 1.5 0.15 11.8 0.5 1.8 1 1 1 2 2 2 0 Domain of unknown function DUF87 AAA_24 PF13479.1 ESA21817.1 - 0.098 12.2 0.5 1.4 8.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA21817.1 - 0.16 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.1 ESA21817.1 - 5.4 7.2 8.8 38 4.5 6.1 2.2 1 1 0 1 1 1 0 AAA domain Hint PF01079.15 ESA21818.1 - 1.5e-31 109.2 0.0 2.6e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Hint module AIG1 PF04548.11 ESA21818.1 - 6.5e-29 100.5 2.1 1.5e-28 99.3 0.1 2.1 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ESA21818.1 - 9.1e-14 51.4 0.1 5.1e-13 48.9 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA21818.1 - 1.3e-06 27.7 0.1 2.6e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Gtr1_RagA PF04670.7 ESA21818.1 - 2.1e-06 27.0 0.1 4.3e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 ESA21818.1 - 5.9e-06 25.6 0.0 1.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.18 ESA21818.1 - 1e-05 25.4 6.7 0.0024 17.6 0.2 3.0 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.13 ESA21818.1 - 0.0001 21.6 0.1 0.00021 20.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.1 ESA21818.1 - 0.00045 20.5 2.2 0.041 14.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_10 PF12846.2 ESA21818.1 - 0.00063 19.2 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain AAA_33 PF13671.1 ESA21818.1 - 0.00072 19.4 0.1 0.0039 17.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 ESA21818.1 - 0.0013 19.0 0.1 0.0029 17.8 0.0 1.7 2 0 0 2 2 1 1 ABC transporter PduV-EutP PF10662.4 ESA21818.1 - 0.0022 17.4 0.1 0.0042 16.5 0.1 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 ESA21818.1 - 0.0042 16.5 0.1 0.0092 15.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Vint PF14623.1 ESA21818.1 - 0.0043 16.5 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Hint-domain AAA_17 PF13207.1 ESA21818.1 - 0.012 16.3 0.4 0.032 15.0 0.3 2.0 1 1 0 1 1 1 0 AAA domain Septin PF00735.13 ESA21818.1 - 0.017 14.1 0.7 0.034 13.1 0.1 1.7 2 0 0 2 2 2 0 Septin AAA_16 PF13191.1 ESA21818.1 - 0.017 15.1 0.4 0.05 13.5 0.2 2.0 2 1 0 2 2 2 0 AAA ATPase domain Miro PF08477.8 ESA21818.1 - 0.035 14.6 0.0 0.076 13.5 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Hpr_kinase_C PF07475.7 ESA21818.1 - 0.043 13.1 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain GTP_EFTU PF00009.22 ESA21818.1 - 0.072 12.5 0.1 0.92 8.9 0.1 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Zeta_toxin PF06414.7 ESA21818.1 - 0.086 11.9 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 ESA21818.1 - 0.13 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 ESA21818.1 - 1.7 8.9 5.8 13 6.0 4.0 2.2 1 1 0 1 1 1 0 AAA domain Hint PF01079.15 ESA21819.1 - 5.2e-32 110.8 0.0 9.7e-32 109.9 0.0 1.5 1 1 0 1 1 1 1 Hint module Vint PF14623.1 ESA21819.1 - 0.00067 19.1 0.0 0.0017 17.8 0.0 1.7 1 1 0 1 1 1 1 Hint-domain Hint_2 PF13403.1 ESA21819.1 - 0.081 12.8 0.0 0.32 10.9 0.0 2.0 1 1 0 1 1 1 0 Hint domain SynMuv_product PF06047.6 ESA21820.1 - 0.013 15.1 1.1 0.084 12.6 0.8 2.2 1 1 0 1 1 1 0 Ras-induced vulval development antagonist Pkinase_Tyr PF07714.12 ESA21823.1 - 2.8e-25 88.8 0.0 3.3e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21823.1 - 1.1e-18 67.3 0.0 1.4e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Cu-binding_MopE PF11617.3 ESA21823.1 - 0.49 10.2 0.1 0.49 10.2 0.1 2.2 3 0 0 3 3 3 0 Protein metal binding site Pkinase_Tyr PF07714.12 ESA21826.1 - 1.1e-37 129.4 0.0 1.6e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21826.1 - 1.5e-27 96.3 0.0 2.4e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-B_box PF00643.19 ESA21826.1 - 0.03 14.2 8.4 0.14 12.0 0.8 2.6 2 0 0 2 2 2 0 B-box zinc finger Stc1 PF12898.2 ESA21826.1 - 0.24 11.4 9.6 2.3 8.3 1.4 2.4 2 0 0 2 2 2 0 Stc1 domain Tnp_zf-ribbon_2 PF13842.1 ESA21826.1 - 0.5 10.8 11.1 0.57 10.6 1.5 2.6 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Ribosomal_L32p PF01783.18 ESA21826.1 - 0.92 9.7 3.7 19 5.5 0.2 2.4 2 0 0 2 2 2 0 Ribosomal L32p protein family TLD PF07534.11 ESA21827.1 - 2.4e-11 43.8 3.0 7.5e-11 42.1 0.7 2.5 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA21827.1 - 0.0012 18.6 3.3 0.0024 17.6 1.9 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch Ribosomal_S18 PF01084.15 ESA21828.1 - 0.01 15.6 0.1 0.022 14.6 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S18 BTB PF00651.26 ESA21829.1 - 2.9e-19 69.1 0.1 5.5e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA21829.1 - 3.7e-11 42.7 4.4 2.6e-08 33.6 0.3 3.7 3 1 0 3 3 3 2 BTB And C-terminal Kelch Imm22 PF15592.1 ESA21829.1 - 0.058 13.7 0.9 2.4 8.4 0.3 2.7 3 0 0 3 3 3 0 Immunity protein 22 Cupin_4 PF08007.7 ESA21829.1 - 0.058 12.6 0.1 0.097 11.8 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein RPM2 PF08579.6 ESA21829.1 - 0.079 13.0 0.3 0.48 10.5 0.0 2.3 1 1 1 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) PIF1 PF05970.9 ESA21830.1 - 7.5e-22 77.7 0.0 9.1e-22 77.4 0.0 1.1 1 0 0 1 1 1 1 PIF1-like helicase ResIII PF04851.10 ESA21830.1 - 0.00091 19.0 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 ESA21830.1 - 0.0013 18.4 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain PhoH PF02562.11 ESA21830.1 - 0.0023 17.2 0.0 0.0032 16.7 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.1 ESA21830.1 - 0.0028 17.6 0.0 0.0039 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Arch_ATPase PF01637.13 ESA21830.1 - 0.004 16.8 0.1 0.0083 15.8 0.0 1.5 1 1 0 1 1 1 1 Archaeal ATPase DUF2075 PF09848.4 ESA21830.1 - 0.0085 15.1 0.2 0.014 14.3 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.1 ESA21830.1 - 0.0097 15.3 0.0 0.02 14.2 0.0 1.5 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.1 ESA21830.1 - 0.011 15.3 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA21830.1 - 0.011 14.6 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 ESA21830.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.10 ESA21830.1 - 0.018 13.6 0.0 0.021 13.4 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein Kinesin PF00225.18 ESA21830.1 - 0.024 13.3 0.0 0.026 13.2 0.0 1.0 1 0 0 1 1 1 0 Kinesin motor domain Zeta_toxin PF06414.7 ESA21830.1 - 0.043 12.8 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 ESA21830.1 - 0.051 13.4 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2791 PF10923.3 ESA21830.1 - 0.06 11.9 0.0 0.075 11.6 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) KAP_NTPase PF07693.9 ESA21830.1 - 0.068 12.1 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA PF00004.24 ESA21830.1 - 0.071 13.3 0.7 0.42 10.8 0.0 2.1 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 ESA21830.1 - 0.093 12.6 1.0 0.59 10.0 0.0 2.0 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.17 ESA21830.1 - 0.096 12.8 0.1 1.8 8.7 0.0 2.1 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.12 ESA21830.1 - 0.1 12.0 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF1548 PF07579.6 ESA21834.1 - 0.073 13.1 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) Imm6 PF14434.1 ESA21837.1 - 0.023 14.3 0.1 0.041 13.6 0.1 1.4 1 0 0 1 1 1 0 Immunity protein Imm6 L51_S25_CI-B8 PF05047.11 ESA21838.1 - 2.4e-14 52.7 0.6 1.7e-13 50.0 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CENP-N PF05238.8 ESA21839.1 - 4.3e-48 164.3 3.5 5.5e-48 163.9 2.4 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like c-SKI_SMAD_bind PF08782.5 ESA21840.1 - 0.011 15.8 0.1 0.018 15.1 0.0 1.3 1 1 0 1 1 1 0 c-SKI Smad4 binding domain Muted PF14942.1 ESA21841.1 - 0.019 14.8 0.1 0.069 13.0 0.1 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein CHCH PF06747.8 ESA21842.1 - 3e-08 33.3 4.0 5.2e-08 32.5 2.8 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 ESA21842.1 - 0.0059 16.6 3.7 0.016 15.2 2.5 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 ESA21842.1 - 0.085 12.6 3.7 0.19 11.5 2.6 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF3067 PF11267.3 ESA21842.1 - 0.14 12.2 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3067) COX17 PF05051.8 ESA21842.1 - 0.2 11.7 0.6 0.2 11.7 0.4 2.5 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.7 ESA21842.1 - 0.46 10.3 4.3 1.2 9.0 0.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) Pkinase_Tyr PF07714.12 ESA21847.1 - 8.5e-07 28.2 0.0 9.8e-07 28.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21847.1 - 0.021 13.9 0.0 0.025 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21849.1 - 2.2e-32 112.1 0.0 2.5e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21849.1 - 1e-24 87.1 0.0 1.3e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Cu-binding_MopE PF11617.3 ESA21849.1 - 4.3 7.2 7.8 1.4 8.7 0.8 2.6 2 0 0 2 2 2 0 Protein metal binding site BTB PF00651.26 ESA21851.1 - 1.4e-18 66.8 0.1 1.8e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 BTB/POZ domain RYDR_ITPR PF01365.16 ESA21851.1 - 0.0066 15.6 0.3 0.008 15.4 0.2 1.2 1 0 0 1 1 1 1 RIH domain GST_N_3 PF13417.1 ESA21852.1 - 1e-12 48.1 0.0 2.2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 ESA21852.1 - 1.4e-12 47.3 0.0 2.9e-12 46.4 0.0 1.6 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 ESA21852.1 - 3.2e-09 36.8 0.0 5.3e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 ESA21852.1 - 1.1e-08 34.9 0.0 2.6e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 ESA21852.1 - 4.3e-07 29.7 0.0 6.6e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ATP-synt_J PF04911.7 ESA21852.1 - 0.14 11.6 0.0 0.54 9.7 0.0 1.9 2 0 0 2 2 2 0 ATP synthase j chain IncA PF04156.9 ESA21853.1 - 0.00049 19.7 8.8 0.00049 19.7 6.1 1.6 2 0 0 2 2 2 1 IncA protein TMF_DNA_bd PF12329.3 ESA21853.1 - 0.0053 16.5 12.4 0.23 11.2 3.9 2.7 1 1 1 2 2 2 2 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 ESA21853.1 - 0.007 15.8 12.5 1.8 8.1 0.4 3.5 1 1 2 3 3 3 2 Septum formation initiator DUF904 PF06005.7 ESA21853.1 - 0.022 15.0 13.2 0.48 10.7 2.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF904) YscO PF07321.7 ESA21853.1 - 0.024 14.4 6.0 0.055 13.2 4.2 1.6 1 0 0 1 1 1 0 Type III secretion protein YscO GldM_N PF12081.3 ESA21853.1 - 0.036 13.5 10.8 0.025 14.1 4.7 2.1 1 1 1 2 2 2 0 GldM N-terminal domain DUF4482 PF14818.1 ESA21853.1 - 0.038 14.6 13.6 0.031 14.9 7.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) bZIP_1 PF00170.16 ESA21853.1 - 0.039 13.8 11.3 0.65 9.9 1.6 3.4 2 1 2 4 4 4 0 bZIP transcription factor bZIP_2 PF07716.10 ESA21853.1 - 0.16 11.8 9.5 8.1 6.3 0.2 3.8 2 1 0 3 3 3 0 Basic region leucine zipper DUF465 PF04325.8 ESA21853.1 - 0.19 11.4 4.6 0.3 10.8 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF465) DUF4303 PF14136.1 ESA21853.1 - 0.21 11.2 4.4 0.26 10.9 1.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) FUSC PF04632.7 ESA21853.1 - 0.21 9.9 0.9 0.26 9.6 0.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-F_leu_zip PF10473.4 ESA21853.1 - 0.36 10.6 16.5 0.038 13.8 7.1 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 ESA21853.1 - 0.36 9.8 14.5 0.2 10.6 8.2 1.9 1 1 0 1 1 1 0 Autophagy protein Apg6 GAS PF13851.1 ESA21853.1 - 0.42 9.7 14.9 0.17 11.0 8.5 1.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.7 ESA21853.1 - 0.48 10.8 3.9 1.1 9.6 0.1 2.7 2 0 0 2 2 2 0 SlyX Microtub_assoc PF07989.6 ESA21853.1 - 0.81 9.5 6.1 4 7.3 3.8 2.4 1 1 1 2 2 2 0 Microtubule associated FadA PF09403.5 ESA21853.1 - 1 9.4 15.0 3.3 7.7 4.4 2.2 2 0 0 2 2 2 0 Adhesion protein FadA Atg14 PF10186.4 ESA21853.1 - 1.7 7.5 9.6 2 7.2 6.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HALZ PF02183.13 ESA21853.1 - 1.9 8.2 11.1 2.8 7.7 0.1 4.0 2 1 0 3 3 3 0 Homeobox associated leucine zipper Striatin PF08232.7 ESA21853.1 - 2.2 8.5 16.0 11 6.2 11.0 2.4 1 1 0 1 1 1 0 Striatin family CALCOCO1 PF07888.6 ESA21853.1 - 2.3 6.3 14.6 4.1 5.5 0.8 1.9 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF972 PF06156.8 ESA21853.1 - 2.6 8.4 12.6 84 3.5 8.6 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) HalX PF08663.5 ESA21853.1 - 2.8 7.9 9.3 0.71 9.8 3.5 2.3 2 1 0 2 2 2 0 HalX domain NYD-SP28_assoc PF14775.1 ESA21853.1 - 2.9 7.6 6.6 28 4.5 0.6 3.5 3 0 0 3 3 3 0 Sperm tail C-terminal domain TPR_MLP1_2 PF07926.7 ESA21853.1 - 4.7 6.9 13.9 2 8.1 5.1 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein tRNA_anti-codon PF01336.20 ESA21854.1 - 0.011 15.5 0.1 0.2 11.5 0.0 2.3 1 1 1 2 2 2 0 OB-fold nucleic acid binding domain APO_RNA-bind PF05634.6 ESA21855.1 - 0.043 13.0 0.0 0.064 12.4 0.0 1.3 1 0 0 1 1 1 0 APO RNA-binding DUF1599 PF07659.6 ESA21856.1 - 0.11 12.6 0.1 0.48 10.5 0.0 2.1 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1599) AAA_12 PF13087.1 ESA21857.1 - 2.7e-19 69.3 0.1 1e-18 67.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 ESA21857.1 - 2e-14 53.7 0.1 3.6e-06 26.7 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 ESA21857.1 - 1.9e-08 34.1 0.0 6.1e-08 32.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 ESA21857.1 - 0.00014 21.5 0.0 0.0019 17.8 0.0 2.6 3 0 0 3 3 3 1 Part of AAA domain Cas_Cas4 PF01930.12 ESA21857.1 - 0.0016 18.3 6.3 0.002 18.0 1.4 3.1 1 1 1 2 2 2 1 Domain of unknown function DUF83 AAA_22 PF13401.1 ESA21857.1 - 0.021 14.9 0.0 0.08 13.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain NUFIP2 PF15293.1 ESA21859.1 - 0.064 11.9 0.3 0.078 11.6 0.2 1.0 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 OTT_1508_deam PF14441.1 ESA21860.1 - 5.8e-12 45.6 0.1 8.6e-12 45.0 0.1 1.2 1 0 0 1 1 1 1 OTT_1508-like deaminase DYW_deaminase PF14432.1 ESA21860.1 - 0.03 14.3 0.2 0.055 13.4 0.1 1.4 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases MafB19-deam PF14437.1 ESA21860.1 - 0.14 11.8 0.1 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 MafB19-like deaminase Bd3614-deam PF14439.1 ESA21860.1 - 0.74 9.6 5.3 0.72 9.7 0.3 2.5 2 1 1 3 3 3 0 Bd3614-like deaminase Rota_NS26 PF01525.11 ESA21862.1 - 0.12 12.1 0.4 0.14 11.9 0.3 1.1 1 0 0 1 1 1 0 Rotavirus NS26 ATP1G1_PLM_MAT8 PF02038.11 ESA21863.1 - 0.014 14.4 0.1 0.023 13.7 0.0 1.3 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family HTH_18 PF12833.2 ESA21864.1 - 0.098 12.7 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain Pox_A_type_inc PF04508.7 ESA21864.1 - 1.8 8.5 4.0 5.6 7.0 0.2 2.2 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Foamy_virus_ENV PF03408.9 ESA21865.1 - 0.0011 16.6 0.3 0.0012 16.5 0.2 1.0 1 0 0 1 1 1 1 Foamy virus envelope protein LolA PF03548.10 ESA21865.1 - 0.034 13.7 1.6 0.034 13.7 1.1 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA ActA PF05058.7 ESA21867.1 - 0.01 13.8 1.2 0.012 13.6 0.9 1.1 1 0 0 1 1 1 0 ActA Protein RRM_6 PF14259.1 ESA21867.1 - 0.11 12.4 0.0 4.9 7.2 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) IncA PF04156.9 ESA21868.1 - 0.018 14.6 5.9 0.035 13.7 4.1 1.4 1 0 0 1 1 1 0 IncA protein YhfH PF14149.1 ESA21868.1 - 0.055 13.2 0.5 0.15 11.8 0.3 1.7 1 0 0 1 1 1 0 YhfH-like protein NPV_P10 PF05531.7 ESA21868.1 - 0.17 12.1 5.4 1.3 9.3 3.7 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DASH_Dad3 PF08656.5 ESA21868.1 - 0.85 9.3 5.8 0.92 9.2 0.8 2.6 1 1 1 2 2 2 0 DASH complex subunit Dad3 Syntaxin-6_N PF09177.6 ESA21868.1 - 1 9.7 5.5 1.2 9.5 1.0 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal IncA PF04156.9 ESA21869.1 - 0.011 15.3 5.9 0.014 15.0 4.1 1.1 1 0 0 1 1 1 0 IncA protein Urb2 PF10441.4 ESA21869.1 - 0.014 15.0 0.9 0.017 14.7 0.6 1.2 1 0 0 1 1 1 0 Urb2/Npa2 family Herpes_UL6 PF01763.11 ESA21869.1 - 0.019 13.1 1.9 0.02 13.1 1.3 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like Tropomyosin_1 PF12718.2 ESA21869.1 - 0.034 13.9 2.7 0.064 13.0 1.8 1.5 1 0 0 1 1 1 0 Tropomyosin like DUF4404 PF14357.1 ESA21869.1 - 0.11 12.9 2.3 0.22 11.9 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) ADIP PF11559.3 ESA21869.1 - 0.18 11.7 9.3 0.23 11.3 6.5 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.15 ESA21869.1 - 0.18 11.5 2.9 1.3 8.7 0.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit Osmo_CC PF08946.5 ESA21869.1 - 0.38 10.8 2.5 2.8 8.0 1.1 2.4 1 1 1 2 2 2 0 Osmosensory transporter coiled coil Prefoldin PF02996.12 ESA21869.1 - 0.87 9.2 5.8 2.8 7.6 1.3 2.3 1 1 1 2 2 2 0 Prefoldin subunit Filament PF00038.16 ESA21869.1 - 0.91 8.9 5.9 1.1 8.6 4.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein DUF972 PF06156.8 ESA21869.1 - 2.5 8.5 4.9 2.7 8.3 2.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FlxA PF14282.1 ESA21869.1 - 2.8 7.9 14.5 4.3 7.3 7.8 2.2 1 1 1 2 2 2 0 FlxA-like protein NPV_P10 PF05531.7 ESA21869.1 - 3.9 7.7 6.1 20 5.5 4.2 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.7 ESA21869.1 - 8.6 6.8 9.3 17 5.8 2.3 2.4 1 1 1 2 2 2 0 SlyX PIP5K PF01504.13 ESA21872.1 - 4.2e-68 229.1 0.8 8.2e-68 228.2 0.6 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 ESA21872.1 - 1.4e-28 99.8 0.1 2.9e-28 98.7 0.1 1.5 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 ESA21872.1 - 1.6e-16 59.9 10.7 1.6e-16 59.9 7.4 2.9 3 0 0 3 3 3 1 FYVE zinc finger Dopey_N PF04118.9 ESA21873.1 - 1.9e-112 375.0 0.7 5.9e-112 373.4 0.0 2.2 2 0 0 2 2 2 1 Dopey, N-terminal DUF368 PF04018.8 ESA21873.1 - 0.12 11.5 0.7 0.29 10.2 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF368) Pkinase_Tyr PF07714.12 ESA21874.1 - 1.1e-51 175.4 0.0 1.4e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21874.1 - 3.6e-49 167.2 0.0 7e-49 166.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain YchF-GTPase_C PF06071.8 ESA21874.1 - 0.041 13.6 0.1 0.28 11.0 0.0 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF933) APH PF01636.18 ESA21874.1 - 0.083 12.6 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Baculo_PEP_C PF04513.7 ESA21875.1 - 5.5 6.8 6.9 0.3 10.8 0.3 2.2 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus BTB PF00651.26 ESA21877.1 - 3.9e-15 55.8 0.7 5.8e-15 55.2 0.5 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA21877.1 - 1.8e-05 24.0 0.2 2.3e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BACK PF07707.10 ESA21877.1 - 9.2e-05 22.2 2.5 0.011 15.5 0.2 3.3 4 0 0 4 4 4 1 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA21877.1 - 0.0024 17.9 0.2 0.0052 16.8 0.1 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain CcoS PF03597.10 ESA21878.1 - 0.0012 18.2 0.0 0.0046 16.3 0.0 2.0 1 0 0 1 1 1 1 Cytochrome oxidase maturation protein cbb3-type EphA2_TM PF14575.1 ESA21878.1 - 0.024 15.0 0.0 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ASFV_J13L PF05568.6 ESA21878.1 - 0.06 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3357 PF11837.3 ESA21878.1 - 0.14 12.0 0.0 2.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) EphA2_TM PF14575.1 ESA21879.1 - 0.0023 18.2 0.0 0.031 14.6 0.0 2.6 3 0 0 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain DUF3357 PF11837.3 ESA21879.1 - 0.015 15.1 0.0 0.45 10.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3357) CcoS PF03597.10 ESA21879.1 - 0.035 13.5 1.1 0.16 11.4 0.8 2.2 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type DUF1510 PF07423.6 ESA21879.1 - 0.061 12.6 0.8 0.12 11.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1510) ASFV_J13L PF05568.6 ESA21879.1 - 0.068 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein Conotoxin PF02950.12 ESA21879.1 - 0.12 13.2 0.0 0.26 12.1 0.0 1.5 1 0 0 1 1 1 0 Conotoxin TMEM154 PF15102.1 ESA21879.1 - 0.32 10.7 4.9 0.27 10.9 0.1 2.9 4 0 0 4 4 4 0 TMEM154 protein family Voldacs PF03517.8 ESA21879.1 - 0.63 9.8 5.8 3.3 7.5 0.0 2.6 2 1 0 2 2 2 0 Regulator of volume decrease after cellular swelling GATA PF00320.22 ESA21880.1 - 1.5e-13 49.7 7.6 4.9e-13 48.1 4.9 2.1 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 ESA21880.1 - 0.00028 20.1 1.6 0.00044 19.5 1.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 ESA21880.1 - 0.0029 16.7 5.1 0.032 13.4 0.6 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.2 ESA21880.1 - 0.004 16.9 4.3 0.031 14.0 3.0 1.9 1 1 0 1 1 1 1 Double zinc ribbon DUF3439 PF11921.3 ESA21880.1 - 0.11 12.1 0.5 0.13 12.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) V4R PF02830.13 ESA21880.1 - 0.13 12.0 1.1 0.4 10.5 0.0 2.1 1 1 1 2 2 2 0 V4R domain ADK_lid PF05191.9 ESA21880.1 - 0.15 11.7 2.5 8.6 6.1 1.8 2.5 1 1 0 1 1 1 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.5 ESA21880.1 - 0.17 11.8 0.4 0.17 11.8 0.3 1.8 2 0 0 2 2 2 0 Zinc ribbon domain UPF0547 PF10571.4 ESA21880.1 - 0.29 10.8 1.5 4.3 7.1 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Zn_Tnp_IS91 PF14319.1 ESA21880.1 - 0.3 10.6 10.7 1.4 8.4 7.4 2.0 1 1 0 1 1 1 0 Transposase zinc-binding domain GFA PF04828.9 ESA21880.1 - 0.82 9.6 4.9 0.59 10.1 1.6 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme ArfGap PF01412.13 ESA21880.1 - 1 9.1 5.4 0.24 11.1 1.0 1.8 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Prim_Zn_Ribbon PF08273.7 ESA21880.1 - 1 9.4 5.7 0.77 9.8 1.8 2.2 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase OrfB_Zn_ribbon PF07282.6 ESA21880.1 - 1.5 8.5 4.0 4.2 7.1 2.8 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.1 ESA21880.1 - 1.6 8.3 5.6 2 8.0 0.7 2.3 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.22 ESA21881.1 - 1.1e-17 63.0 4.1 1.5e-17 62.6 2.8 1.2 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 ESA21881.1 - 0.00021 20.5 0.8 0.0003 20.0 0.6 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding RRN7 PF11781.3 ESA21881.1 - 0.0024 17.3 0.6 0.0034 16.8 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 ArfGap PF01412.13 ESA21881.1 - 0.012 15.3 0.3 0.015 15.1 0.2 1.1 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf zf-FCS PF06467.9 ESA21881.1 - 0.02 14.4 0.4 1 9.0 0.0 2.1 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DZR PF12773.2 ESA21881.1 - 0.033 14.0 1.4 0.065 13.0 1.0 1.6 1 1 0 1 1 1 0 Double zinc ribbon eIF-5_eIF-2B PF01873.12 ESA21881.1 - 0.04 13.5 0.4 0.06 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Prim_Zn_Ribbon PF08273.7 ESA21881.1 - 0.047 13.7 2.2 0.078 13.0 1.5 1.3 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase Zn-ribbon_8 PF09723.5 ESA21881.1 - 0.061 13.2 0.1 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Zinc ribbon domain NMD3 PF04981.8 ESA21881.1 - 0.095 11.7 0.2 0.089 11.9 0.2 1.1 1 0 0 1 1 1 0 NMD3 family zf-Sec23_Sec24 PF04810.10 ESA21881.1 - 0.12 11.9 1.0 0.15 11.6 0.7 1.2 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger COX5B PF01215.14 ESA21881.1 - 0.16 11.6 0.6 0.24 11.0 0.4 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase subunit Vb zf-ribbon_3 PF13248.1 ESA21881.1 - 0.27 10.5 4.8 0.89 8.8 3.3 1.8 1 1 0 1 1 1 0 zinc-ribbon domain GSu_C4xC__C2xCH PF09698.5 ESA21881.1 - 2.6 8.2 6.1 1.4 9.1 2.7 1.6 1 1 0 1 1 1 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) YABBY PF04690.8 ESA21883.1 - 0.039 14.2 0.6 0.065 13.4 0.4 1.5 1 1 0 1 1 1 0 YABBY protein Sel1 PF08238.7 ESA21884.1 - 1.8e-54 180.9 15.2 2.6e-12 46.9 0.1 6.2 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA21884.1 - 9.2e-07 28.9 3.2 1.4 9.5 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 ESA21884.1 - 7.9e-05 22.1 0.6 2.7 8.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21884.1 - 0.0017 18.2 7.0 0.26 11.2 0.3 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA21884.1 - 0.0047 17.5 0.1 0.043 14.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.13 ESA21884.1 - 0.039 13.8 6.3 16 5.5 0.2 4.7 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain PPR PF01535.15 ESA21884.1 - 0.16 12.0 2.5 5.9 7.0 0.1 4.1 5 0 0 5 5 5 0 PPR repeat Tetraspannin PF00335.15 ESA21887.1 - 0.0029 16.8 0.9 0.038 13.2 0.0 2.2 2 0 0 2 2 2 1 Tetraspanin family DUF4064 PF13273.1 ESA21887.1 - 0.0045 17.0 1.9 0.037 14.1 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4064) Shisa PF13908.1 ESA21887.1 - 0.0065 16.6 0.0 0.0065 16.6 0.0 2.6 2 1 0 3 3 3 1 Wnt and FGF inhibitory regulator 7TM_GPCR_Str PF10326.4 ESA21887.1 - 0.0086 15.2 2.4 0.0086 15.2 1.7 2.0 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Str Leu_Phe_trans PF03588.9 ESA21887.1 - 0.01 15.0 0.3 0.017 14.2 0.2 1.3 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase DUF1183 PF06682.7 ESA21887.1 - 0.015 14.8 0.0 0.04 13.5 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1183) Rhabdo_glycop PF00974.13 ESA21887.1 - 0.02 13.1 0.0 0.03 12.5 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein GP41 PF00517.12 ESA21887.1 - 0.025 14.1 0.1 0.054 13.0 0.1 1.5 1 0 0 1 1 1 0 Retroviral envelope protein L1R_F9L PF02442.12 ESA21887.1 - 0.038 13.4 3.4 0.097 12.1 0.5 2.2 2 0 0 2 2 2 0 Lipid membrane protein of large eukaryotic DNA viruses DUF912 PF06024.7 ESA21887.1 - 0.14 12.2 6.8 0.22 11.5 1.5 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) ODV-E18 PF10717.4 ESA21887.1 - 0.18 11.2 2.1 0.79 9.2 0.2 2.3 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Sigma_reg_N PF13800.1 ESA21887.1 - 0.25 11.4 7.8 0.36 10.8 1.5 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF3753 PF12575.3 ESA21887.1 - 1.1 9.1 11.6 2 8.2 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) SdpI PF13630.1 ESA21887.1 - 2.1 8.1 7.1 5.7 6.7 1.2 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF872 PF05915.7 ESA21888.1 - 0.11 12.3 0.2 0.11 12.3 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) P12 PF12669.2 ESA21888.1 - 0.26 11.4 3.3 2.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Virus attachment protein p12 family Connexin PF00029.14 ESA21888.1 - 0.38 10.8 1.9 0.55 10.3 0.0 2.0 2 0 0 2 2 2 0 Connexin DUF2976 PF11190.3 ESA21888.1 - 0.48 9.9 3.0 0.43 10.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Sex_peptide PF08138.6 ESA21888.1 - 0.75 9.6 2.3 25 4.8 1.1 2.4 2 0 0 2 2 2 0 Sex peptide (SP) family DUF2668 PF10873.3 ESA21888.1 - 8.1 6.5 6.6 1.2 9.2 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2668) Pkinase_Tyr PF07714.12 ESA21889.1 - 5e-06 25.7 0.0 0.00015 20.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21889.1 - 6.7e-05 22.1 0.0 0.00011 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA21890.1 - 7.5e-18 64.6 0.4 5.9e-17 61.6 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21890.1 - 1.5e-15 56.9 0.0 1.1e-12 47.6 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase p450 PF00067.17 ESA21891.1 - 0.0069 14.9 0.0 0.007 14.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.17 ESA21893.1 - 0.0053 15.3 0.0 0.38 9.2 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Prominin PF05478.6 ESA21893.1 - 0.067 10.7 0.1 0.075 10.5 0.1 1.1 1 0 0 1 1 1 0 Prominin Borrelia_orfA PF02414.10 ESA21895.1 - 0.00089 18.4 1.0 0.00089 18.4 0.7 1.9 1 1 1 2 2 2 1 Borrelia ORF-A Rgp1 PF08737.5 ESA21896.1 - 0.32 10.0 9.5 1.1 8.2 0.6 2.1 2 0 0 2 2 2 0 Rgp1 DARPP-32 PF05395.7 ESA21896.1 - 8.4 6.5 16.6 0.47 10.6 6.3 2.0 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 Ferritin PF00210.19 ESA21896.1 - 9.9 5.9 10.3 0.54 10.0 1.7 2.7 3 1 1 4 4 4 0 Ferritin-like domain Pkinase_Tyr PF07714.12 ESA21897.1 - 0.00093 18.3 0.0 0.00099 18.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase CoiA PF06054.6 ESA21904.1 - 0.096 11.5 0.0 0.11 11.3 0.0 1.0 1 0 0 1 1 1 0 Competence protein CoiA-like family Pkinase PF00069.20 ESA21906.1 - 2e-47 161.5 0.0 4e-47 160.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21906.1 - 2.8e-47 160.9 0.0 3.7e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA21906.1 - 1.2e-05 24.4 0.0 3.5e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 ESA21906.1 - 0.00014 21.2 0.7 0.0008 18.8 0.4 2.1 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ESA21906.1 - 0.0011 18.7 0.0 0.0061 16.3 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA21906.1 - 0.003 16.6 0.0 0.0054 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA21906.1 - 0.043 13.1 0.1 0.11 11.7 0.1 1.7 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL V-ATPase_H_C PF11698.3 ESA21907.1 - 0.014 15.3 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 V-ATPase subunit H zf-ISL3 PF14690.1 ESA21907.1 - 0.034 14.1 0.1 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Acetyltransf_11 PF13720.1 ESA21907.1 - 0.097 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF2083 PF09856.4 ESA21907.1 - 0.11 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) DUF4473 PF14747.1 ESA21907.1 - 0.13 12.4 0.0 0.42 10.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) DDE_1 PF03184.14 ESA21909.1 - 0.00023 20.3 1.4 0.0009 18.4 1.0 1.9 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF2660 PF10859.3 ESA21910.1 - 0.06 13.5 3.5 4.8 7.4 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2660) MLIP PF15274.1 ESA21910.1 - 0.068 12.6 0.2 0.083 12.3 0.1 1.1 1 0 0 1 1 1 0 Muscular LMNA-interacting protein RVT_1 PF00078.22 ESA21911.1 - 6.5e-06 25.6 0.0 7.3e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1926 PF09095.6 ESA21913.1 - 0.0058 15.9 2.1 0.0073 15.5 1.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1926) Glyco_transf_41 PF13844.1 ESA21913.1 - 0.08 10.9 0.6 0.096 10.6 0.4 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 DUF496 PF04363.7 ESA21913.1 - 0.28 11.0 5.7 0.37 10.6 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF496) MP PF01107.13 ESA21913.1 - 1.9 7.8 8.4 2.6 7.3 5.9 1.1 1 0 0 1 1 1 0 Viral movement protein (MP) DUF2518 PF10726.4 ESA21914.1 - 4.6 6.7 5.2 28 4.2 0.9 2.3 1 1 1 2 2 2 0 Protein of function (DUF2518) Choline_transpo PF04515.7 ESA21915.1 - 0.021 13.5 1.1 0.03 13.0 0.8 1.2 1 0 0 1 1 1 0 Plasma-membrane choline transporter DUF599 PF04654.7 ESA21915.1 - 0.043 12.9 2.1 0.063 12.4 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Pox_polyA_pol_C PF12629.2 ESA21916.1 - 0.023 14.4 0.2 0.023 14.4 0.1 2.0 3 0 0 3 3 3 0 Poxvirus poly(A) polymerase C-terminal domain FOP_dimer PF09398.5 ESA21916.1 - 0.088 12.8 0.4 0.24 11.4 0.2 1.8 1 1 0 1 1 1 0 FOP N terminal dimerisation domain LisH PF08513.6 ESA21916.1 - 0.11 12.2 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 LisH Pirin PF02678.11 ESA21917.1 - 4.6e-26 90.7 0.1 8e-26 90.0 0.1 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 ESA21917.1 - 4.8e-21 74.7 0.0 1e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Pirin C-terminal cupin domain TLD PF07534.11 ESA21919.1 - 2.2e-06 27.6 1.4 2.5e-06 27.5 0.9 1.1 1 0 0 1 1 1 1 TLD Pro_isomerase PF00160.16 ESA21920.1 - 1.4e-40 139.0 1.2 2.6e-40 138.1 0.1 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tmp39 PF10271.4 ESA21920.1 - 0.57 8.7 0.9 0.8 8.2 0.6 1.1 1 0 0 1 1 1 0 Putative transmembrane protein Adaptin_N PF01602.15 ESA21921.1 - 1.6e-149 498.6 12.9 2e-149 498.2 8.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 ESA21921.1 - 4.2e-23 81.8 0.7 1.2e-22 80.4 0.5 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.1 ESA21921.1 - 2.7e-06 27.5 0.4 2 8.7 0.0 4.8 3 3 1 4 4 4 2 HEAT repeats Cnd1 PF12717.2 ESA21921.1 - 0.0005 19.9 5.9 0.19 11.5 1.1 3.1 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.5 ESA21921.1 - 0.0043 16.6 0.7 0.033 13.7 0.2 2.7 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) Arm PF00514.18 ESA21921.1 - 0.14 12.0 1.9 1.3e+02 2.6 0.0 5.3 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Shisa PF13908.1 ESA21922.1 - 0.0069 16.5 0.8 0.0069 16.5 0.5 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator AAA PF00004.24 ESA21923.1 - 1.9e-16 60.4 0.0 4e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 ESA21923.1 - 5e-14 52.2 0.0 4.2e-12 46.0 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 ESA21923.1 - 1.6e-13 50.4 0.0 4.8e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta PF06144.8 ESA21923.1 - 2e-09 37.2 0.1 1.2e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 ESA21923.1 - 7e-07 29.2 0.0 2e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 ESA21923.1 - 1.8e-06 26.9 0.3 5e-05 22.1 0.0 2.1 1 1 1 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 ESA21923.1 - 1.1e-05 25.6 0.2 0.0016 18.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 ESA21923.1 - 1.2e-05 25.3 0.0 0.00014 21.9 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.1 ESA21923.1 - 1.9e-05 24.3 0.2 0.00016 21.2 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 ESA21923.1 - 3.1e-05 23.1 0.0 0.00014 20.9 0.0 2.0 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 ESA21923.1 - 0.00018 20.5 0.0 0.00033 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 ESA21923.1 - 0.00024 20.7 0.0 0.00051 19.7 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_24 PF13479.1 ESA21923.1 - 0.00029 20.4 0.0 0.00085 18.9 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 ESA21923.1 - 0.001 18.8 0.1 0.0099 15.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 ESA21923.1 - 0.0027 17.1 0.0 0.0062 15.9 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.10 ESA21923.1 - 0.0033 17.2 0.0 0.022 14.6 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 ESA21923.1 - 0.0096 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 ESA21923.1 - 0.012 14.9 0.2 0.034 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 ESA21923.1 - 0.014 14.9 0.0 0.097 12.1 0.0 2.1 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_10 PF12846.2 ESA21923.1 - 0.015 14.7 0.3 7 5.9 0.0 2.6 2 1 0 3 3 3 0 AAA-like domain Arch_ATPase PF01637.13 ESA21923.1 - 0.03 14.0 0.0 0.086 12.5 0.0 1.7 1 1 0 1 1 1 0 Archaeal ATPase TIP49 PF06068.8 ESA21923.1 - 0.051 12.2 0.0 0.48 9.0 0.0 2.1 2 0 0 2 2 2 0 TIP49 C-terminus AAA_17 PF13207.1 ESA21923.1 - 0.056 14.2 0.0 0.14 12.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 ESA21923.1 - 0.088 12.6 0.0 0.17 11.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESA21923.1 - 0.091 11.9 0.0 0.36 9.9 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.1 ESA21923.1 - 0.17 11.4 0.0 0.49 9.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain HIT PF01230.18 ESA21924.1 - 0.023 15.2 0.3 0.06 13.8 0.2 1.7 1 0 0 1 1 1 0 HIT domain p450 PF00067.17 ESA21925.1 - 1.9e-39 135.4 0.0 2.4e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.1 ESA21926.1 - 6e-21 74.8 0.0 1.4e-20 73.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA21926.1 - 1.7e-19 70.0 0.0 3.2e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA21926.1 - 1.2e-17 63.9 0.0 2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA21926.1 - 2.7e-14 53.4 0.0 6.3e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA21926.1 - 4.2e-14 53.0 0.0 6.8e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA21926.1 - 4.8e-12 46.1 0.0 1.2e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 ESA21926.1 - 5e-08 32.3 0.0 7.4e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 ESA21926.1 - 7.9e-08 31.7 0.0 1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 ESA21926.1 - 1.2e-07 31.1 0.0 1.8e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 ESA21926.1 - 2.6e-07 30.6 0.0 7.4e-07 29.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 ESA21926.1 - 1.2e-06 27.4 0.0 2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.9 ESA21926.1 - 0.0021 17.4 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.6 ESA21926.1 - 0.0047 16.3 0.0 0.0079 15.6 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 ESA21926.1 - 0.015 15.0 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 ESA21926.1 - 0.015 14.6 0.1 0.026 13.9 0.1 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DREV PF05219.7 ESA21926.1 - 0.024 13.4 0.0 0.049 12.4 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase PCMT PF01135.14 ESA21926.1 - 0.032 13.7 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_zinc_N PF00107.21 ESA21926.1 - 0.055 13.0 0.0 0.17 11.4 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase RrnaAD PF00398.15 ESA21926.1 - 0.065 12.2 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TPMT PF05724.6 ESA21926.1 - 0.14 11.5 0.1 0.32 10.3 0.0 1.6 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) Cob_adeno_trans PF01923.13 ESA21927.1 - 9.3e-55 184.8 0.0 1.1e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Nop14 PF04147.7 ESA21928.1 - 0.0083 14.1 16.9 0.0087 14.0 11.7 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2457 PF10446.4 ESA21928.1 - 0.027 13.1 17.3 0.03 13.0 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 ESA21928.1 - 0.059 11.8 14.8 0.062 11.7 10.3 1.1 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 ESA21928.1 - 0.22 10.7 15.6 0.33 10.1 10.8 1.2 1 0 0 1 1 1 0 SDA1 CCDC-167 PF15188.1 ESA21928.1 - 0.51 10.3 0.0 0.51 10.3 0.0 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Usp PF00582.21 ESA21928.1 - 0.94 9.6 4.4 1.6 8.9 3.0 1.3 1 0 0 1 1 1 0 Universal stress protein family Cwf_Cwc_15 PF04889.7 ESA21928.1 - 1.2 8.7 15.7 1.7 8.2 10.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.5 ESA21928.1 - 1.3 7.9 11.6 1.4 7.9 8.0 1.2 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.9 ESA21928.1 - 2 6.3 9.7 2 6.3 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 ESA21928.1 - 2.1 7.6 8.4 3.1 7.1 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) ANAPC15 PF15243.1 ESA21928.1 - 3.7 7.6 27.4 4.2e+02 1.0 19.0 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF4637 PF15470.1 ESA21928.1 - 7.2 6.1 7.9 12 5.4 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PA26 PF04636.8 ESA21929.1 - 0.72 8.4 8.7 0.83 8.2 6.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4407 PF14362.1 ESA21929.1 - 1.3 7.9 8.4 1.7 7.5 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDE_1 PF03184.14 ESA21930.1 - 8.1e-21 74.1 2.2 1.1e-20 73.7 1.5 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA21930.1 - 0.0012 18.5 0.3 0.0021 17.8 0.2 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease UPF0697 PF15117.1 ESA21930.1 - 0.14 11.9 0.9 0.42 10.3 0.2 2.2 2 1 0 2 2 2 0 Uncharacterised protein family UPF0697 DUF3114 PF11311.3 ESA21931.1 - 0.045 13.1 0.0 0.051 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) Aldo_ket_red PF00248.16 ESA21932.1 - 2.6e-30 105.2 0.0 4.1e-30 104.5 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family RNase_H PF00075.19 ESA21933.1 - 0.035 14.4 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 RNase H ubiquitin PF00240.18 ESA21935.1 - 0.088 12.2 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family DDE_1 PF03184.14 ESA21937.1 - 0.00017 20.7 0.1 0.00036 19.7 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Interferon PF00143.14 ESA21938.1 - 0.038 13.8 0.5 5.5 6.8 0.0 2.0 1 1 1 2 2 2 0 Interferon alpha/beta domain Iron_permease PF04120.7 ESA21938.1 - 0.073 12.6 2.6 0.11 12.0 1.8 1.3 1 1 0 1 1 1 0 Low affinity iron permease DUF4368 PF14287.1 ESA21938.1 - 0.082 12.7 1.7 0.11 12.3 0.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4368) Syntaxin-18_N PF10496.4 ESA21938.1 - 0.27 11.0 4.1 0.62 9.9 2.8 1.5 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Pkinase_Tyr PF07714.12 ESA21939.1 - 3.7e-16 58.9 0.0 1.8e-12 46.9 0.0 3.5 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21939.1 - 1.2e-12 47.5 3.6 2.3e-12 46.6 0.1 2.7 3 0 0 3 3 3 1 Protein kinase domain phiKZ_IP PF12699.2 ESA21939.1 - 0.00036 19.5 0.2 0.4 9.5 0.0 3.0 3 0 0 3 3 3 2 phiKZ-like phage internal head proteins BCS1_N PF08740.6 ESA21939.1 - 0.00074 19.1 0.0 3.4 7.2 0.0 3.5 3 0 0 3 3 3 1 BCS1 N terminal DUF3850 PF12961.2 ESA21939.1 - 0.039 13.9 0.9 0.61 10.0 0.0 3.1 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3850) DUF4413 PF14372.1 ESA21939.1 - 0.24 11.4 7.0 8.2 6.4 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) zf-ribbon_3 PF13248.1 ESA21939.1 - 0.8 9.0 15.5 7.5 5.9 0.0 4.6 4 0 0 4 4 4 0 zinc-ribbon domain DUF4047 PF13256.1 ESA21939.1 - 1.8 8.5 7.8 2.7 7.9 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4047) Kelch_2 PF07646.10 ESA21939.1 - 2.4 8.0 5.8 19 5.2 0.2 3.1 3 0 0 3 3 3 0 Kelch motif Sel1 PF08238.7 ESA21940.1 - 5.6e-69 227.0 5.5 1.7e-09 37.9 0.1 9.1 9 0 0 9 9 9 9 Sel1 repeat TPR_6 PF13174.1 ESA21940.1 - 0.0023 18.2 13.3 0.05 14.0 0.0 6.4 8 1 0 8 8 8 1 Tetratricopeptide repeat MTBP_C PF14920.1 ESA21940.1 - 0.04 13.4 1.1 4.9 6.5 0.0 3.3 3 0 0 3 3 3 0 MDM2-binding TPR_11 PF13414.1 ESA21940.1 - 0.066 12.8 21.4 0.13 11.9 1.1 5.7 3 2 4 7 7 7 0 TPR repeat Transgly PF00912.17 ESA21940.1 - 0.11 11.8 2.3 0.16 11.2 0.1 2.1 2 0 0 2 2 2 0 Transglycosylase Pex19 PF04614.7 ESA21941.1 - 0.32 10.5 11.7 0.42 10.1 8.1 1.2 1 0 0 1 1 1 0 Pex19 protein family TAT_signal PF10518.4 ESA21941.1 - 2.5 8.3 10.3 0.42 10.7 2.3 2.3 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence SRP54 PF00448.17 ESA21942.1 - 1.5e-80 269.2 0.2 2.7e-80 268.4 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 ESA21942.1 - 2.9e-15 56.1 2.1 5.7e-15 55.1 1.5 1.5 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.1 ESA21942.1 - 9.3e-08 32.0 0.1 2.3e-07 30.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 ESA21942.1 - 3.4e-07 30.0 0.2 2.2e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 ESA21942.1 - 8.4e-07 28.5 0.1 2e-06 27.3 0.1 1.6 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_31 PF13614.1 ESA21942.1 - 1.4e-06 28.3 0.0 0.056 13.3 0.0 2.5 1 1 0 2 2 2 2 AAA domain CbiA PF01656.18 ESA21942.1 - 5e-06 26.0 0.5 2e-05 24.1 0.0 2.2 2 1 0 2 2 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP_SPB PF02978.14 ESA21942.1 - 5.5e-06 26.5 1.6 5.5e-06 26.5 1.1 3.0 2 1 1 3 3 3 1 Signal peptide binding domain AAA_17 PF13207.1 ESA21942.1 - 2e-05 25.4 0.0 5.9e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 ESA21942.1 - 2.3e-05 23.7 0.5 0.0096 15.1 0.4 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ArgK PF03308.11 ESA21942.1 - 0.00011 21.1 0.0 0.00073 18.3 0.0 2.1 1 1 0 1 1 1 1 ArgK protein AAA_22 PF13401.1 ESA21942.1 - 0.00026 21.1 0.0 0.00088 19.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.1 ESA21942.1 - 0.0027 17.7 0.0 0.01 15.8 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain APS_kinase PF01583.15 ESA21942.1 - 0.003 17.2 0.0 0.0067 16.1 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_25 PF13481.1 ESA21942.1 - 0.003 16.9 0.1 0.03 13.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA21942.1 - 0.0047 17.2 0.1 0.015 15.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 ESA21942.1 - 0.0064 15.8 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Thymidylate kinase ATP_bind_1 PF03029.12 ESA21942.1 - 0.0069 15.9 0.8 0.018 14.6 0.0 2.1 3 0 0 3 3 2 1 Conserved hypothetical ATP binding protein AAA PF00004.24 ESA21942.1 - 0.0083 16.3 0.2 0.058 13.5 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESA21942.1 - 0.0091 15.7 0.0 0.048 13.4 0.0 2.2 3 0 0 3 3 1 1 Part of AAA domain AAA_28 PF13521.1 ESA21942.1 - 0.011 15.7 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 ESA21942.1 - 0.012 14.8 0.1 0.037 13.2 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 ESA21942.1 - 0.014 14.5 0.1 0.041 12.9 0.0 1.8 2 0 0 2 2 1 0 Zeta toxin TrwB_AAD_bind PF10412.4 ESA21942.1 - 0.021 13.4 0.1 0.2 10.2 0.0 2.4 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain VirC1 PF07015.6 ESA21942.1 - 0.028 13.4 0.0 0.056 12.5 0.0 1.5 1 0 0 1 1 1 0 VirC1 protein MipZ PF09140.6 ESA21942.1 - 0.031 13.3 0.0 0.6 9.1 0.0 2.3 1 1 0 1 1 1 0 ATPase MipZ ResIII PF04851.10 ESA21942.1 - 0.036 13.8 0.5 0.077 12.8 0.3 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Paramyxo_P PF01806.12 ESA21942.1 - 0.042 13.1 0.4 0.15 11.3 0.3 1.8 1 1 1 2 2 2 0 Paramyxovirinae P phosphoprotein C-terminal region AAA_10 PF12846.2 ESA21942.1 - 0.043 13.2 0.1 0.098 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA-like domain AAA_30 PF13604.1 ESA21942.1 - 0.059 12.9 0.0 0.12 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.10 ESA21942.1 - 0.061 12.3 1.0 0.18 10.7 0.1 2.3 2 1 0 2 2 2 0 Anion-transporting ATPase NTPase_1 PF03266.10 ESA21942.1 - 0.086 12.5 0.9 0.71 9.5 0.6 2.3 1 1 0 1 1 1 0 NTPase LpxK PF02606.9 ESA21942.1 - 0.097 11.6 0.1 0.22 10.4 0.1 1.5 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase DNA_pol3_chi PF04364.8 ESA21942.1 - 0.13 12.1 0.0 0.34 10.7 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase III chi subunit, HolC YlbD_coat PF14071.1 ESA21942.1 - 1.8 8.6 4.9 0.5 10.4 1.0 1.8 2 0 0 2 2 1 0 Putative coat protein Pterin_bind PF00809.17 ESA21943.1 - 3e-70 235.8 0.0 5e-70 235.1 0.0 1.4 1 0 0 1 1 1 1 Pterin binding enzyme FolB PF02152.13 ESA21943.1 - 2.3e-60 201.7 7.5 5.3e-32 110.3 0.5 2.6 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.15 ESA21943.1 - 8.6e-39 132.1 0.0 2.2e-38 130.8 0.0 1.8 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) CoA_trans PF01144.18 ESA21943.1 - 0.021 14.0 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase DUF4498 PF14926.1 ESA21944.1 - 4.4e-63 212.7 4.4 4.9e-63 212.5 3.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) YqzH PF14164.1 ESA21944.1 - 0.73 9.7 3.7 0.36 10.7 0.4 2.1 2 0 0 2 2 2 0 YqzH-like protein AAA_18 PF13238.1 ESA21944.1 - 0.96 9.7 3.6 5.4 7.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.16 ESA21945.1 - 2.4e-60 204.3 0.0 3.1e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 ESA21945.1 - 0.00046 19.4 0.0 0.00095 18.3 0.0 1.4 2 0 0 2 2 2 1 Beta-eliminating lyase TLD PF07534.11 ESA21946.1 - 0.0083 16.1 1.4 3.8 7.5 0.5 2.3 1 1 1 2 2 2 2 TLD DIOX_N PF14226.1 ESA21948.1 - 4.1e-33 114.3 0.0 6e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 ESA21948.1 - 6.1e-19 68.1 0.0 1e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF608 PF04685.8 ESA21948.1 - 0.087 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF608 Smr PF01713.16 ESA21949.1 - 4.5e-09 36.3 0.0 8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Smr domain Myb_DNA-binding PF00249.26 ESA21950.1 - 0.0015 18.5 2.0 0.24 11.4 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA21950.1 - 0.035 14.1 2.7 0.04 14.0 0.2 2.0 1 1 1 2 2 2 0 Myb-like DNA-binding domain DDE_1 PF03184.14 ESA21951.1 - 4.7e-42 143.5 4.2 7.9e-40 136.2 2.9 2.3 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA21951.1 - 0.00019 21.2 0.3 0.00036 20.3 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease Borrelia_rep PF03183.8 ESA21952.1 - 1.4 8.8 5.6 0.23 11.2 0.6 2.2 2 0 0 2 2 2 0 Borrelia repeat protein DUF3455 PF11937.3 ESA21953.1 - 8.3e-21 74.7 0.4 8.3e-20 71.4 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) Cyto_heme_lyase PF01265.12 ESA21954.1 - 3.7e-45 154.5 3.0 4.5e-45 154.2 2.1 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase V-ATPase_C PF03223.10 ESA21957.1 - 8e-05 21.7 0.0 0.00012 21.1 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit C ABC_tran PF00005.22 ESA21959.1 - 1.5e-27 96.5 0.0 2.3e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA21959.1 - 6.7e-06 26.2 1.8 0.00033 20.7 0.3 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 ESA21959.1 - 8.9e-05 22.5 0.1 0.00013 22.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 ESA21959.1 - 9e-05 23.2 0.0 0.00014 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 ESA21959.1 - 9.7e-05 21.2 0.0 0.00011 21.0 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein DUF258 PF03193.11 ESA21959.1 - 0.00046 19.3 0.0 0.00053 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 ESA21959.1 - 0.001 19.2 0.4 0.0054 16.9 0.2 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 ESA21959.1 - 0.0016 17.8 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA21959.1 - 0.002 17.8 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ESA21959.1 - 0.007 16.2 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 ESA21959.1 - 0.0075 16.2 0.4 0.012 15.5 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA21959.1 - 0.0088 16.1 0.1 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.17 ESA21959.1 - 0.0089 14.9 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.1 ESA21959.1 - 0.012 15.9 0.3 0.026 14.8 0.1 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 ESA21959.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 ESA21959.1 - 0.014 14.8 0.1 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_19 PF13245.1 ESA21959.1 - 0.014 15.1 0.1 0.029 14.0 0.1 1.5 1 0 0 1 1 1 0 Part of AAA domain PRK PF00485.13 ESA21959.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.1 ESA21959.1 - 0.031 13.8 0.0 0.064 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 ESA21959.1 - 0.041 13.5 0.4 0.064 12.9 0.3 1.3 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 ESA21959.1 - 0.05 13.3 0.3 0.088 12.5 0.2 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_35 PF14516.1 ESA21959.1 - 0.063 11.9 0.0 0.095 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.18 ESA21959.1 - 0.088 12.7 0.3 0.15 12.0 0.2 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ArgK PF03308.11 ESA21959.1 - 0.088 11.5 0.6 0.14 10.9 0.1 1.5 2 0 0 2 2 2 0 ArgK protein cobW PF02492.14 ESA21959.1 - 0.088 12.2 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.1 ESA21959.1 - 0.09 12.3 0.1 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 ESA21959.1 - 0.092 12.4 0.3 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 NTPase SRPRB PF09439.5 ESA21959.1 - 0.096 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UPF0079 PF02367.12 ESA21959.1 - 0.1 12.2 0.4 0.2 11.2 0.1 1.6 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_5 PF07728.9 ESA21959.1 - 0.11 12.2 0.2 0.62 9.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.15 ESA21959.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_23 PF13476.1 ESA21959.1 - 0.15 12.3 1.2 0.32 11.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.4 ESA21959.1 - 0.15 11.5 0.2 0.29 10.6 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.1 ESA21959.1 - 0.19 11.6 0.4 0.26 11.1 0.3 1.5 1 1 0 1 1 1 0 AAA domain DUF4251 PF14059.1 ESA21963.1 - 0.018 14.8 0.3 0.037 13.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) DUF2198 PF09964.4 ESA21964.1 - 0.19 11.5 1.2 0.36 10.6 0.8 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) DUF2972 PF11186.3 ESA21965.1 - 0.046 13.6 6.2 0.16 11.8 4.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2972) PRE_C2HC PF07530.6 ESA21965.1 - 0.051 13.4 0.9 0.16 11.8 0.6 2.0 1 1 0 1 1 1 0 Associated with zinc fingers ArfGap PF01412.13 ESA21966.1 - 1.6e-39 134.3 2.2 4.5e-39 132.8 1.0 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 ESA21966.1 - 2.2e-16 59.9 0.1 9.3e-16 57.9 0.0 2.2 1 0 0 1 1 1 1 PH domain Ank_2 PF12796.2 ESA21966.1 - 1.4e-10 41.3 2.2 5.7e-09 36.2 1.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA21966.1 - 1.2e-09 38.3 2.3 2.9e-05 24.4 0.8 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA21966.1 - 2.2e-09 37.2 2.1 2e-06 27.8 0.7 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PH_11 PF15413.1 ESA21966.1 - 3.9e-07 30.2 2.3 1e-05 25.7 1.6 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain Ank PF00023.25 ESA21966.1 - 1.3e-06 27.9 2.4 0.0059 16.3 0.3 4.0 4 0 0 4 4 3 2 Ankyrin repeat PH_8 PF15409.1 ESA21966.1 - 6.4e-05 22.9 0.0 0.00042 20.3 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_3 PF13606.1 ESA21966.1 - 0.0013 18.7 1.3 1.1 9.7 0.2 3.3 3 0 0 3 3 3 1 Ankyrin repeat PH_9 PF15410.1 ESA21966.1 - 0.0048 17.0 0.1 0.032 14.3 0.0 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.1 ESA21966.1 - 0.0059 16.4 0.6 0.022 14.6 0.0 2.4 3 0 0 3 3 3 1 PH domain TLD PF07534.11 ESA21969.1 - 2.4e-10 40.5 0.4 5e-10 39.5 0.3 1.6 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA21969.1 - 8e-05 22.4 0.7 0.00069 19.4 0.5 2.3 1 1 0 1 1 1 1 BTB And C-terminal Kelch Sel1 PF08238.7 ESA21971.1 - 1.8e-20 72.8 11.7 1.3e-13 51.1 1.8 2.2 2 0 0 2 2 2 2 Sel1 repeat MIT PF04212.13 ESA21971.1 - 0.0088 15.9 7.9 0.47 10.3 0.4 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain DUF3674 PF12426.3 ESA21971.1 - 0.032 13.6 3.7 0.29 10.5 0.2 2.9 3 0 0 3 3 3 0 RNA dependent RNA polymerase TPR_20 PF14561.1 ESA21971.1 - 0.078 13.1 0.6 0.3 11.2 0.3 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21971.1 - 0.22 11.4 6.1 0.59 10.1 4.0 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA21971.1 - 0.9 9.8 5.5 4.5 7.7 0.8 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA21971.1 - 1.5 9.4 7.2 0.59 10.7 0.7 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat MRP-L46 PF11788.3 ESA21971.1 - 3 8.5 5.5 9.4 6.9 0.4 2.2 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 DUF2659 PF10858.3 ESA21973.1 - 0.045 13.1 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) Pkinase_Tyr PF07714.12 ESA21974.1 - 1.2e-07 31.0 0.0 2.1e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21974.1 - 0.0015 17.7 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF3910 PF13049.1 ESA21975.1 - 0.1 12.7 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3910) Zn-ribbon_8 PF09723.5 ESA21976.1 - 0.071 13.0 0.2 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Zinc ribbon domain LUC7 PF03194.10 ESA21977.1 - 0.026 14.0 1.6 0.032 13.7 1.1 1.1 1 0 0 1 1 1 0 LUC7 N_terminus XhlA PF10779.4 ESA21977.1 - 0.23 11.4 5.6 0.34 10.8 3.9 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Exonuc_VII_L PF02601.10 ESA21977.1 - 0.35 10.0 2.9 0.4 9.8 2.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TetR_C_8 PF14278.1 ESA21977.1 - 0.92 9.9 3.9 0.98 9.8 0.3 2.2 1 1 0 2 2 2 0 Transcriptional regulator C-terminal region DDE_3 PF13358.1 ESA21979.1 - 3e-09 36.7 0.0 4e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease BTB PF00651.26 ESA21980.1 - 1.5e-18 66.8 0.1 1.7e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain Coat_F PF07875.7 ESA21981.1 - 0.0083 16.2 0.1 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Coat F domain Bro-N PF02498.12 ESA21981.1 - 0.031 14.5 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 BRO family, N-terminal domain Pkinase PF00069.20 ESA21982.1 - 0.04 13.0 0.1 0.064 12.3 0.1 1.4 1 1 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA21982.1 - 0.045 12.8 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA21983.1 - 3.5e-23 81.9 0.1 4.3e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA21983.1 - 8.2e-21 74.3 0.2 1.1e-20 73.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA21983.1 - 0.021 13.8 0.2 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Orthopox_F7 PF05813.7 ESA21983.1 - 0.08 12.8 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Orthopoxvirus F7 protein ABC2_membrane PF01061.19 ESA21985.1 - 5.2e-20 71.5 9.4 7.1e-20 71.0 6.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 ESA21986.1 - 4.2e-11 43.2 0.0 6.8e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 ESA21986.1 - 1.7e-05 24.9 0.0 2.1e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.1 ESA21986.1 - 0.00067 18.8 0.1 0.001 18.1 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain MBOAT_2 PF13813.1 ESA21987.1 - 1.7e-09 37.6 1.6 3.4e-09 36.6 1.1 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family NS3_envE PF02723.9 ESA21987.1 - 4.5 7.2 6.5 1.5 8.7 0.7 2.8 2 1 1 3 3 3 0 Non-structural protein NS3/Small envelope protein E VKOR PF07884.9 ESA21987.1 - 5.7 6.7 7.6 0.54 10.1 0.2 2.5 2 1 0 2 2 2 0 Vitamin K epoxide reductase family DUF2304 PF10066.4 ESA21987.1 - 8.2 6.3 9.6 0.42 10.4 1.2 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) F-box-like PF12937.2 ESA21988.1 - 6.6e-06 25.7 0.1 1.2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA21988.1 - 9.4e-05 21.9 0.5 0.0002 20.9 0.3 1.6 1 0 0 1 1 1 1 F-box domain Lamp PF01299.12 ESA21988.1 - 0.016 14.3 4.6 0.024 13.7 3.2 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) DUF3439 PF11921.3 ESA21988.1 - 0.048 13.4 5.2 0.09 12.5 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) adh_short PF00106.20 ESA21989.1 - 4.7e-29 101.4 0.0 6.9e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA21989.1 - 4.1e-27 95.4 0.0 8e-27 94.5 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA21989.1 - 1.6e-08 34.3 0.0 2.3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 KR domain MiaE PF06175.6 ESA21989.1 - 0.044 13.1 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) DUF1776 PF08643.5 ESA21989.1 - 0.076 12.1 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 ESA21989.1 - 0.12 12.2 0.2 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase EcsC PF12787.2 ESA21990.1 - 0.0027 17.1 0.2 0.0056 16.1 0.2 1.4 1 0 0 1 1 1 1 EcsC protein family FliG_M PF14841.1 ESA21990.1 - 0.093 12.7 0.6 7.3 6.6 0.0 2.8 3 0 0 3 3 3 0 FliG middle domain DUF697 PF05128.7 ESA21990.1 - 0.1 12.0 0.6 1.1 8.7 0.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF697) Abhydrolase_6 PF12697.2 ESA21991.1 - 9.2e-21 74.7 0.0 1.2e-20 74.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA21991.1 - 1.4e-11 44.4 0.1 1.1e-10 41.4 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 ESA21991.1 - 1.6e-10 40.9 0.0 2.7e-10 40.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 ESA21991.1 - 0.0017 17.9 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Peptidase_S9 PF00326.16 ESA21991.1 - 0.0074 15.5 0.0 0.16 11.1 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.3 ESA21991.1 - 0.037 13.8 0.0 0.084 12.7 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase PAF-AH_p_II PF03403.8 ESA21991.1 - 0.17 10.1 0.3 4.6 5.4 0.0 2.2 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Sel1 PF08238.7 ESA21992.1 - 6.1e-49 163.3 12.9 3.7e-12 46.4 0.8 6.1 6 0 0 6 6 6 6 Sel1 repeat Arginosuc_synth PF00764.14 ESA21992.1 - 0.0012 17.9 0.0 0.0015 17.6 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase TPR_11 PF13414.1 ESA21992.1 - 0.0034 17.0 20.5 0.53 9.9 3.9 4.5 2 2 3 5 5 5 3 TPR repeat TPR_8 PF13181.1 ESA21992.1 - 0.05 13.4 15.5 2.9 7.8 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat AdoMet_MTase PF07757.8 ESA21992.1 - 0.13 12.3 0.8 24 5.0 0.0 3.3 2 1 2 4 4 4 0 Predicted AdoMet-dependent methyltransferase TPR_16 PF13432.1 ESA21992.1 - 0.16 12.7 2.1 0.25 12.0 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA21992.1 - 0.21 11.4 3.9 0.91 9.4 0.1 3.9 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA21992.1 - 0.58 10.1 9.8 3.3 7.7 0.6 4.9 2 2 2 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 ESA21992.1 - 2.2 8.2 16.1 15 5.5 0.2 5.0 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA21992.1 - 2.7 7.7 6.9 28 4.5 0.0 4.1 3 2 1 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation MBOAT_2 PF13813.1 ESA21994.1 - 1.7e-11 44.0 0.7 4.6e-11 42.6 0.5 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family MBOAT_2 PF13813.1 ESA21995.1 - 1.9e-11 43.8 4.7 5.2e-11 42.4 3.2 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family MBOAT_2 PF13813.1 ESA21996.1 - 0.006 16.6 0.3 0.024 14.7 0.2 2.0 1 1 0 1 1 1 1 Membrane bound O-acyl transferase family DUF1071 PF06378.6 ESA21996.1 - 0.032 13.3 0.0 0.054 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) Abhydro_lipase PF04083.11 ESA21996.1 - 0.073 12.4 0.0 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Pkinase_Tyr PF07714.12 ESA21997.1 - 1.1e-33 116.4 0.0 3.5e-19 68.8 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA21997.1 - 1.4e-27 96.5 0.2 4.4e-18 65.3 0.0 2.5 1 1 1 2 2 2 2 Protein kinase domain GOLGA2L5 PF15070.1 ESA21997.1 - 0.15 10.5 0.1 0.21 10.0 0.1 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 MBOAT_2 PF13813.1 ESA21998.1 - 1.9e-13 50.2 1.4 4.1e-13 49.2 1.0 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family AAA-ATPase_like PF09820.4 ESA22000.1 - 7e-40 136.9 10.5 7e-40 136.9 7.3 2.8 3 0 0 3 3 3 1 Predicted AAA-ATPase Sel1 PF08238.7 ESA22001.1 - 5.1e-28 96.8 3.9 1e-12 48.2 0.1 3.1 3 0 0 3 3 3 3 Sel1 repeat MIT PF04212.13 ESA22001.1 - 1.4 8.8 5.3 4.2 7.3 1.0 2.8 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain p450 PF00067.17 ESA22003.1 - 2.1e-06 26.5 0.8 2.7e-06 26.2 0.6 1.1 1 0 0 1 1 1 1 Cytochrome P450 MBOAT_2 PF13813.1 ESA22004.1 - 0.094 12.8 1.3 0.14 12.2 0.9 1.3 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family AMP-binding PF00501.23 ESA22006.1 - 2.8e-95 319.1 0.0 3.7e-95 318.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme RRM_1 PF00076.17 ESA22007.1 - 2.5e-20 71.8 0.1 4.1e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22007.1 - 6.9e-15 54.7 0.0 1.3e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA22007.1 - 5.8e-09 35.6 0.1 9.7e-09 34.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.27 ESA22008.1 - 8e-24 81.0 10.9 5.8e-07 28.3 0.5 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 ESA22008.1 - 2.4e-23 79.8 4.5 3.1e-06 26.5 0.3 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 ESA22008.1 - 6.8e-22 77.3 5.3 5e-14 52.1 0.2 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 ESA22008.1 - 6.3e-19 66.3 7.7 2.5e-06 26.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 ESA22008.1 - 2.1e-13 49.6 12.4 5.7e-07 29.0 0.2 4.2 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.2 ESA22008.1 - 1.9e-08 33.9 6.0 0.067 12.9 0.1 4.0 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA22008.1 - 6.8e-05 22.8 3.6 0.0091 16.0 0.2 3.2 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 ESA22008.1 - 0.00093 19.0 0.9 0.31 11.0 0.1 3.5 2 1 1 3 3 3 1 EF-hand domain S10_plectin PF03501.10 ESA22008.1 - 0.068 13.0 0.0 0.12 12.2 0.0 1.5 1 1 0 1 1 1 0 Plectin/S10 domain MutS_V PF00488.16 ESA22009.1 - 3.1e-87 291.8 0.2 6.1e-87 290.9 0.2 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 ESA22009.1 - 1.7e-35 122.6 2.1 4e-35 121.4 1.4 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 ESA22009.1 - 2.9e-24 85.2 0.0 7.1e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 ESA22009.1 - 6.8e-12 45.6 0.0 2.6e-11 43.7 0.0 2.1 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.13 ESA22009.1 - 2.7e-07 30.6 0.3 2.3e-06 27.6 0.0 2.6 2 0 0 2 2 2 1 MutS family domain IV AAA_14 PF13173.1 ESA22009.1 - 0.02 14.7 2.0 2.4 8.0 0.0 3.5 3 1 0 3 3 3 0 AAA domain AAA_29 PF13555.1 ESA22009.1 - 0.041 13.4 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sel1 PF08238.7 ESA22011.1 - 8.8e-18 64.3 0.0 7.5e-10 39.1 0.0 2.2 2 0 0 2 2 2 2 Sel1 repeat TPR_11 PF13414.1 ESA22011.1 - 0.0054 16.3 0.0 1.5 8.5 0.0 2.2 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.1 ESA22011.1 - 0.084 13.1 0.0 5.4 7.4 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat MutS_III PF05192.13 ESA22013.1 - 0.041 13.6 13.1 0.062 13.0 8.1 2.0 1 1 0 1 1 1 0 MutS domain III TPR_11 PF13414.1 ESA22017.1 - 6.9e-11 41.6 0.3 1.9e-10 40.2 0.0 1.9 2 0 0 2 2 2 1 TPR repeat SET PF00856.23 ESA22017.1 - 8.9e-09 35.8 0.5 3.3e-07 30.7 0.0 2.6 2 1 0 2 2 2 1 SET domain TPR_16 PF13432.1 ESA22017.1 - 0.026 15.2 0.4 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22017.1 - 0.05 13.8 0.0 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_2 PF13347.1 ESA22018.1 - 6.4e-40 136.8 29.3 1.4e-30 106.0 12.7 2.0 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1 PF07690.11 ESA22018.1 - 2.8e-07 29.5 21.5 2.8e-07 29.5 14.9 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF754 PF05449.6 ESA22018.1 - 0.17 11.9 0.1 0.17 11.9 0.1 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF754) Peripla_BP_3 PF13377.1 ESA22019.1 - 9.8e-18 64.6 0.0 2.4e-17 63.4 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LacI PF00356.16 ESA22019.1 - 3.1e-16 58.6 0.1 6.2e-16 57.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.16 ESA22019.1 - 2e-09 37.0 0.0 4.1e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family HTH_Crp_2 PF13545.1 ESA22019.1 - 0.0058 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_10 PF04967.7 ESA22019.1 - 0.046 13.2 0.0 0.098 12.2 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain Crp PF00325.15 ESA22019.1 - 0.083 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family MarR_2 PF12802.2 ESA22019.1 - 0.085 12.5 0.0 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 MarR family HTH_23 PF13384.1 ESA22019.1 - 0.14 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain NUMOD1 PF07453.8 ESA22019.1 - 0.17 11.8 0.6 0.95 9.4 0.0 2.4 2 0 0 2 2 2 0 NUMOD1 domain Sel1 PF08238.7 ESA22020.1 - 4.1e-77 252.9 33.6 3.6e-10 40.1 0.7 11.2 11 0 0 11 11 11 11 Sel1 repeat MIT PF04212.13 ESA22020.1 - 1.4 8.8 21.2 11 5.9 0.8 6.1 4 2 2 6 6 6 0 MIT (microtubule interacting and transport) domain OTT_1508_deam PF14441.1 ESA22021.1 - 0.084 12.6 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 OTT_1508-like deaminase DnaI_N PF07319.6 ESA22021.1 - 0.28 11.4 0.1 0.28 11.4 0.0 2.3 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus DivIC PF04977.10 ESA22022.1 - 2.9e-06 26.6 7.5 0.00082 18.8 1.0 2.2 1 1 1 2 2 2 2 Septum formation initiator CENP-F_leu_zip PF10473.4 ESA22022.1 - 8e-05 22.5 9.0 0.00011 22.0 6.3 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.14 ESA22022.1 - 0.00019 21.0 1.3 0.00023 20.7 0.9 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family bZIP_2 PF07716.10 ESA22022.1 - 0.0003 20.5 9.3 0.04 13.7 1.1 2.2 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.16 ESA22022.1 - 0.00058 19.7 11.0 0.0024 17.8 1.0 2.2 1 1 1 2 2 2 1 bZIP transcription factor Fmp27_WPPW PF10359.4 ESA22022.1 - 0.0006 18.3 1.9 0.00072 18.0 1.3 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Shugoshin_N PF07558.6 ESA22022.1 - 0.00087 18.9 4.7 0.017 14.8 1.4 2.3 1 1 1 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF724 PF05266.9 ESA22022.1 - 0.0022 17.6 4.0 0.0031 17.1 2.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) IncA PF04156.9 ESA22022.1 - 0.0047 16.5 8.2 0.0069 16.0 5.7 1.2 1 0 0 1 1 1 1 IncA protein DUF904 PF06005.7 ESA22022.1 - 0.01 16.0 12.0 0.39 11.0 3.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF904) V_ATPase_I PF01496.14 ESA22022.1 - 0.011 13.6 0.6 0.011 13.6 0.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CALCOCO1 PF07888.6 ESA22022.1 - 0.018 13.3 3.5 0.024 12.9 2.4 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF972 PF06156.8 ESA22022.1 - 0.019 15.3 7.1 0.068 13.5 5.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) HALZ PF02183.13 ESA22022.1 - 0.024 14.3 9.1 0.053 13.2 4.9 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF4201 PF13870.1 ESA22022.1 - 0.025 14.0 3.3 0.034 13.5 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF342 PF03961.8 ESA22022.1 - 0.044 12.1 1.4 0.053 11.9 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) APG6 PF04111.7 ESA22022.1 - 0.045 12.7 7.0 0.058 12.4 4.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 MAD PF05557.8 ESA22022.1 - 0.058 11.4 5.3 0.12 10.4 3.7 1.4 1 1 0 1 1 1 0 Mitotic checkpoint protein DUF3166 PF11365.3 ESA22022.1 - 0.079 13.4 5.2 1.4 9.4 0.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) TMF_TATA_bd PF12325.3 ESA22022.1 - 0.1 12.3 6.9 0.72 9.5 4.8 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.3 ESA22022.1 - 0.1 12.4 5.5 0.15 11.9 3.8 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Packaging_FI PF14000.1 ESA22022.1 - 0.11 12.6 1.6 0.16 12.1 1.1 1.3 1 0 0 1 1 1 0 DNA packaging protein FI Mto2_bdg PF12808.2 ESA22022.1 - 0.15 12.1 6.4 1.1 9.4 1.1 2.2 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region CASP_C PF08172.7 ESA22022.1 - 0.18 10.8 7.2 2 7.3 5.0 2.0 1 1 0 1 1 1 0 CASP C terminal TLE_N PF03920.10 ESA22022.1 - 0.18 11.5 1.3 0.32 10.8 0.9 1.4 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain DUF1319 PF07028.6 ESA22022.1 - 0.47 10.6 5.3 11 6.2 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1319) NYD-SP28_assoc PF14775.1 ESA22022.1 - 0.49 10.1 5.7 0.49 10.1 1.0 2.2 1 1 1 2 2 2 0 Sperm tail C-terminal domain TBPIP PF07106.8 ESA22022.1 - 0.5 9.8 8.7 0.8 9.2 2.7 1.5 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) NUDE_C PF04880.8 ESA22022.1 - 0.55 10.5 6.0 0.72 10.2 3.6 1.6 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region HalX PF08663.5 ESA22022.1 - 1.8 8.6 10.0 0.2 11.6 3.4 1.9 2 0 0 2 2 2 0 HalX domain Ax_dynein_light PF10211.4 ESA22022.1 - 1.8 8.3 8.5 2.4 7.9 2.2 1.9 1 1 1 2 2 2 0 Axonemal dynein light chain Spc24 PF08286.6 ESA22022.1 - 2.5 7.8 9.6 5.6 6.6 5.4 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 IFP_35_N PF07334.8 ESA22022.1 - 2.6 8.0 5.5 26 4.8 0.7 2.5 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Sugarporin_N PF11471.3 ESA22022.1 - 3.1 7.5 6.4 0.81 9.3 0.2 2.2 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension M PF02370.11 ESA22022.1 - 4.7 7.8 10.6 15 6.3 0.5 2.8 2 1 1 3 3 3 0 M protein repeat TSC22 PF01166.13 ESA22022.1 - 5.7 6.9 10.4 4 7.4 0.9 2.4 1 1 1 2 2 2 0 TSC-22/dip/bun family GrpE PF01025.14 ESA22022.1 - 6 6.3 9.3 8 5.9 1.4 2.0 1 1 1 2 2 2 0 GrpE Ribosomal_L29 PF00831.18 ESA22022.1 - 9.1 6.0 9.1 0.7 9.6 0.6 2.2 2 0 0 2 2 2 0 Ribosomal L29 protein Uricase PF01014.13 ESA22025.1 - 0.0016 18.4 0.1 0.0024 17.9 0.1 1.3 1 0 0 1 1 1 1 Uricase PDGF_N PF04692.8 ESA22025.1 - 0.067 13.6 1.2 0.31 11.5 0.1 2.1 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region Ion_trans PF00520.26 ESA22026.1 - 0.00072 18.8 4.8 0.001 18.3 3.3 1.2 1 0 0 1 1 1 1 Ion transport protein Imm22 PF15592.1 ESA22026.1 - 0.053 13.8 0.7 0.11 12.8 0.1 1.8 2 0 0 2 2 2 0 Immunity protein 22 MACPF PF01823.14 ESA22027.1 - 3.6e-07 30.0 1.1 3.6e-07 30.0 0.8 2.8 2 1 0 3 3 3 1 MAC/Perforin domain DNA_PPF PF02916.10 ESA22028.1 - 0.21 11.6 2.6 0.14 12.2 0.5 1.6 2 0 0 2 2 2 0 DNA polymerase processivity factor p450 PF00067.17 ESA22029.1 - 8e-11 41.1 1.3 8.6e-10 37.7 0.9 2.5 1 1 0 1 1 1 1 Cytochrome P450 IF3_C PF00707.17 ESA22030.1 - 2.4e-11 43.2 0.7 4.7e-11 42.2 0.5 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.1 ESA22030.1 - 7.5e-05 22.1 11.2 0.00041 19.7 7.7 2.2 1 1 0 1 1 1 1 Mitochondrial translation initiation factor IF3_N PF05198.11 ESA22030.1 - 0.0036 17.1 0.8 0.0036 17.1 0.5 2.3 2 1 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain gp32 PF08804.5 ESA22030.1 - 0.11 12.6 1.1 0.32 11.1 0.1 2.2 2 1 1 3 3 3 0 gp32 DNA binding protein like HGTP_anticodon PF03129.15 ESA22030.1 - 0.13 12.2 1.4 5.5 7.0 0.1 2.9 2 1 0 3 3 3 0 Anticodon binding domain NUT_C PF12882.2 ESA22030.1 - 1.5 8.3 6.8 0.32 10.6 1.8 1.9 1 1 1 2 2 2 0 NUT protein C terminal Pkinase PF00069.20 ESA22031.1 - 4.7e-31 107.8 0.0 5.3e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22031.1 - 6.3e-30 104.1 0.0 7.5e-30 103.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA22031.1 - 0.00031 20.5 0.1 0.0025 17.5 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Baculo_PEP_N PF04512.7 ESA22031.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, N terminus APH_6_hur PF04655.9 ESA22031.1 - 0.027 13.6 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Kdo PF06293.9 ESA22031.1 - 0.091 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3867 PF12983.2 ESA22032.1 - 0.0054 16.7 2.6 0.0063 16.5 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3867) Peptidase_U4 PF03419.8 ESA22032.1 - 0.042 12.9 0.4 0.056 12.5 0.3 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Bap31 PF05529.7 ESA22032.1 - 0.049 13.0 0.6 0.06 12.7 0.4 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like HAMP PF00672.20 ESA22032.1 - 0.097 12.8 0.0 0.14 12.3 0.0 1.3 1 1 0 1 1 1 0 HAMP domain zf-C2H2 PF00096.21 ESA22033.1 - 0.004 17.4 2.1 0.004 17.4 1.4 2.6 3 0 0 3 3 3 1 Zinc finger, C2H2 type CENP-L PF13092.1 ESA22033.1 - 0.1 12.3 0.8 0.15 11.8 0.4 1.5 1 1 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 zf-C2H2_jaz PF12171.3 ESA22033.1 - 9.6 6.4 8.0 7.7 6.8 0.6 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF92 PF01940.11 ESA22034.1 - 1.9e-70 236.5 1.5 2.2e-70 236.3 1.0 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 DUF3169 PF11368.3 ESA22034.1 - 0.00053 19.2 4.0 0.064 12.4 1.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3169) DUF4341 PF14241.1 ESA22034.1 - 0.32 10.7 5.7 5.2 6.8 3.9 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4341) MIP PF00230.15 ESA22038.1 - 2.4e-55 187.4 15.1 2.9e-55 187.1 10.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein Nop14 PF04147.7 ESA22041.1 - 0.51 8.2 22.4 0.55 8.0 15.5 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 ESA22041.1 - 2.3 7.4 20.9 3 7.0 14.5 1.2 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.6 ESA22041.1 - 8.1 4.4 14.4 9.6 4.1 10.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pkinase_Tyr PF07714.12 ESA22043.1 - 3.5e-07 29.5 0.7 6.8e-07 28.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22043.1 - 0.0005 19.2 0.4 0.0012 18.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain DUF137 PF02006.11 ESA22043.1 - 0.019 14.3 0.2 1.8 7.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF137 KMP11 PF03037.11 ESA22043.1 - 0.021 15.4 0.2 0.032 14.8 0.2 1.4 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 TaqI_C PF12950.2 ESA22043.1 - 0.038 13.7 2.5 0.042 13.5 1.0 1.6 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain DUF1540 PF07561.6 ESA22044.1 - 0.037 14.0 0.1 0.094 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1540) Ion_trans PF00520.26 ESA22044.1 - 2.8 7.1 11.1 0.078 12.2 2.7 2.0 2 1 0 2 2 2 0 Ion transport protein Ion_trans PF00520.26 ESA22045.1 - 0.00021 20.6 18.0 0.032 13.4 12.5 2.3 1 1 0 1 1 1 1 Ion transport protein TRP PF06011.7 ESA22045.1 - 0.006 15.1 5.5 0.0091 14.6 3.8 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel LRRNT_2 PF08263.7 ESA22045.1 - 0.4 10.6 2.4 8.2 6.4 0.1 2.4 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain TFCD_C PF12612.3 ESA22046.1 - 0.062 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal BTB PF00651.26 ESA22047.1 - 8.1e-20 70.8 0.0 1.8e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22047.1 - 0.004 16.9 6.6 0.0089 15.8 0.5 3.8 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA22047.1 - 0.019 14.1 0.0 0.03 13.4 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) LCCL PF03815.14 ESA22048.1 - 0.073 13.0 0.1 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 LCCL domain DUF3590 PF12148.3 ESA22048.1 - 0.11 12.0 2.7 0.33 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3590) TLD PF07534.11 ESA22049.1 - 2.3e-09 37.3 2.0 3.2e-09 36.9 1.4 1.3 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA22053.1 - 4e-10 39.6 0.0 7.1e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22053.1 - 4.5e-06 26.4 5.8 3.7e-05 23.4 1.8 3.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch RasGEF_N PF00618.15 ESA22053.1 - 0.37 10.9 3.8 3.1 7.9 2.2 2.7 1 1 1 2 2 2 0 RasGEF N-terminal motif BTB PF00651.26 ESA22054.1 - 4.2e-14 52.4 0.0 4.8e-14 52.2 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA22054.1 - 0.021 13.9 0.0 0.025 13.7 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF1090 PF06476.7 ESA22056.1 - 0.045 13.4 3.3 0.069 12.8 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) NYN_YacP PF05991.6 ESA22056.1 - 0.053 13.2 0.5 0.062 13.0 0.4 1.1 1 0 0 1 1 1 0 YacP-like NYN domain HPD PF05044.7 ESA22056.1 - 0.085 12.5 1.0 0.11 12.2 0.7 1.0 1 0 0 1 1 1 0 Homeo-prospero domain KLRAQ PF10205.4 ESA22056.1 - 0.1 12.6 4.8 0.21 11.6 3.4 1.6 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein AATF-Che1 PF13339.1 ESA22056.1 - 0.14 12.3 6.7 0.19 11.8 4.6 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor OmpH PF03938.9 ESA22056.1 - 0.28 11.0 6.1 0.35 10.7 4.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Flg_hook PF02120.11 ESA22056.1 - 0.35 10.5 4.1 0.23 11.1 0.6 2.0 1 1 1 2 2 2 0 Flagellar hook-length control protein FliK UPF0242 PF06785.6 ESA22056.1 - 0.37 9.4 5.4 0.43 9.1 3.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) IBB PF01749.15 ESA22056.1 - 0.7 10.0 6.3 0.89 9.7 4.4 1.1 1 0 0 1 1 1 0 Importin beta binding domain Histone_HNS PF00816.16 ESA22056.1 - 1.2 9.6 4.1 0.51 10.8 1.2 1.5 2 0 0 2 2 2 0 H-NS histone family Exonuc_VII_L PF02601.10 ESA22056.1 - 2.2 7.4 9.0 2.6 7.1 6.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Helitron_like_N PF14214.1 ESA22057.1 - 3.3e-33 114.9 0.1 7.4e-33 113.8 0.0 1.6 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus PIF1 PF05970.9 ESA22058.1 - 1.4e-09 37.3 0.0 1.5e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase Herpes_Helicase PF02689.9 ESA22059.1 - 2.7e-06 25.4 0.0 2.9e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA22059.1 - 0.054 13.6 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Bax1-I PF01027.15 ESA22060.1 - 0.0089 15.6 6.9 0.013 15.0 4.8 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Frizzled PF01534.12 ESA22060.1 - 0.015 14.1 0.3 0.017 13.8 0.2 1.2 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF3593 PF12159.3 ESA22060.1 - 0.015 15.0 0.3 0.03 14.0 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3593) DC_STAMP PF07782.8 ESA22060.1 - 0.037 13.6 0.1 0.039 13.5 0.1 1.2 1 0 0 1 1 1 0 DC-STAMP-like protein FecCD PF01032.13 ESA22060.1 - 0.19 10.5 6.3 0.27 10.0 4.4 1.3 1 1 0 1 1 1 0 FecCD transport family Kei1 PF08552.6 ESA22060.1 - 0.58 9.7 4.3 0.13 11.9 0.4 1.7 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Tetraspannin PF00335.15 ESA22060.1 - 1 8.5 12.6 2 7.6 6.2 2.0 1 1 0 2 2 2 0 Tetraspanin family DUF1774 PF08611.5 ESA22060.1 - 1.1 9.4 6.1 1.1 9.5 2.3 2.0 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1774) SUR7 PF06687.7 ESA22060.1 - 1.2 8.6 8.8 0.15 11.6 2.7 1.6 1 1 1 2 2 2 0 SUR7/PalI family NfeD PF01957.13 ESA22060.1 - 1.8 8.6 5.9 13 5.9 4.1 2.0 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding Claudin_2 PF13903.1 ESA22060.1 - 2.5 7.7 8.6 4 7.1 5.9 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction MARVEL PF01284.18 ESA22060.1 - 6.7 6.5 10.9 1.1 9.0 2.8 2.0 1 1 1 2 2 2 0 Membrane-associating domain HSP70 PF00012.15 ESA22061.1 - 0.00012 20.1 0.1 0.001 17.1 0.0 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESA22061.1 - 0.00017 20.3 0.0 0.31 9.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein PGM_PMM_II PF02879.11 ESA22061.1 - 0.058 13.7 0.0 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II vWF_A PF12450.3 ESA22062.1 - 0.0017 18.0 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor RTBV_P12 PF06361.6 ESA22062.1 - 0.011 15.9 0.1 0.015 15.5 0.1 1.2 1 0 0 1 1 1 0 Rice tungro bacilliform virus P12 protein DUF3510 PF12022.3 ESA22062.1 - 0.058 13.5 6.0 2.3 8.3 0.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3510) CENP-I PF07778.6 ESA22063.1 - 0.17 10.0 1.0 0.19 9.9 0.7 1.0 1 0 0 1 1 1 0 Mis6 DUF3039 PF11238.3 ESA22063.1 - 0.91 9.0 3.3 22 4.5 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3039) BTB PF00651.26 ESA22065.1 - 3.2e-18 65.7 0.2 7.9e-18 64.4 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA22065.1 - 8.4e-08 31.9 9.5 6.4e-07 29.1 0.5 4.2 5 1 1 6 6 6 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA22065.1 - 0.052 13.6 0.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain Sel1 PF08238.7 ESA22066.1 - 6.6e-56 185.5 16.8 1.5e-13 50.9 0.3 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA22066.1 - 6.7e-12 45.0 8.5 0.017 15.5 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22066.1 - 1.3e-07 31.2 11.2 0.83 10.0 0.1 6.0 3 2 2 6 6 6 3 Tetratricopeptide repeat MIT PF04212.13 ESA22066.1 - 3.6e-07 29.9 14.2 0.25 11.2 0.4 4.3 4 0 0 4 4 4 4 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA22066.1 - 5e-06 26.0 21.6 0.021 14.4 2.8 4.6 1 1 4 5 5 5 4 TPR repeat TPR_12 PF13424.1 ESA22066.1 - 5.4e-06 26.2 13.8 0.016 15.1 1.2 4.5 1 1 3 4 4 4 4 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA22066.1 - 0.0046 16.6 2.7 9.1 6.1 0.0 3.9 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation NifW PF03206.9 ESA22066.1 - 0.011 15.8 2.5 1.6 8.8 0.1 2.9 1 1 1 3 3 3 0 Nitrogen fixation protein NifW Ribonuc_red_sm PF00268.16 ESA22066.1 - 0.041 12.8 1.8 1.6 7.6 0.1 2.1 1 1 1 2 2 2 0 Ribonucleotide reductase, small chain TPR_1 PF00515.23 ESA22066.1 - 0.056 13.0 25.4 10 5.9 0.2 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22066.1 - 0.08 13.6 1.8 3.2 8.5 0.1 3.0 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22066.1 - 0.083 12.8 25.0 4.9 7.3 0.3 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 ESA22066.1 - 0.11 11.3 6.6 0.47 9.2 0.6 2.0 2 0 0 2 2 2 0 Spatacsin C-terminus BssC_TutF PF08201.6 ESA22066.1 - 0.42 10.1 12.3 1 8.8 0.1 3.2 3 1 1 4 4 4 0 BssC/TutF protein B2-adapt-app_C PF09066.5 ESA22066.1 - 0.49 10.2 2.8 11 5.9 0.1 2.7 1 1 1 3 3 3 0 Beta2-adaptin appendage, C-terminal sub-domain TFIIB PF00382.14 ESA22066.1 - 3.1 7.6 7.9 81 3.1 0.0 3.9 4 0 0 4 4 4 0 Transcription factor TFIIB repeat DUF3674 PF12426.3 ESA22066.1 - 5 6.6 10.3 26 4.3 0.0 4.1 4 0 0 4 4 4 0 RNA dependent RNA polymerase Proteasom_Rpn13 PF04683.8 ESA22066.1 - 9.1 6.4 6.7 50 4.0 0.1 3.3 3 1 0 3 3 3 0 Proteasome complex subunit Rpn13 ubiquitin receptor TLD PF07534.11 ESA22068.1 - 3.9e-11 43.0 4.3 9.6e-11 41.8 1.7 2.3 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA22068.1 - 4.3e-09 36.3 0.1 9.2e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22068.1 - 5.3e-07 29.4 6.9 3.4e-05 23.6 0.2 4.2 4 1 1 5 5 5 2 BTB And C-terminal Kelch Glyco_hydro_17 PF00332.13 ESA22068.1 - 0.035 13.1 0.1 0.057 12.4 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 Ricin_B_lectin PF00652.17 ESA22070.1 - 4.8e-06 26.6 0.0 0.001 19.0 0.0 1.9 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 ESA22070.1 - 0.00047 20.4 0.0 0.00069 19.9 0.0 1.4 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like ATP-synt_ab_N PF02874.18 ESA22070.1 - 0.11 12.7 0.2 4.3 7.6 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain RicinB_lectin_2 PF14200.1 ESA22071.1 - 2.8e-13 50.1 0.5 2.1e-08 34.4 0.1 1.4 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA22071.1 - 3.6e-09 36.7 0.1 9.7e-06 25.6 0.1 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain BTB PF00651.26 ESA22073.1 - 4.6e-14 52.3 0.1 7.2e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA22073.1 - 0.012 14.8 0.1 0.016 14.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) AAA_10 PF12846.2 ESA22073.1 - 0.053 12.9 0.0 0.057 12.8 0.0 1.0 1 0 0 1 1 1 0 AAA-like domain DUF2847 PF11009.3 ESA22073.1 - 0.098 12.2 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) DUF2283 PF10049.4 ESA22075.1 - 2.8e-08 33.4 9.7 0.00071 19.3 0.2 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2283) tRNA_anti-codon PF01336.20 ESA22075.1 - 0.004 16.9 0.2 2 8.3 0.0 3.2 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain Uds1 PF15456.1 ESA22075.1 - 0.12 12.3 0.7 0.45 10.5 0.1 1.9 2 0 0 2 2 2 0 Up-regulated During Septation DUF3828 PF12883.2 ESA22076.1 - 0.062 13.2 0.7 0.068 13.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) zf-SNAP50_C PF12251.3 ESA22076.1 - 0.23 10.7 1.4 0.26 10.6 1.0 1.0 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal TraT PF05818.7 ESA22078.1 - 0.0032 16.9 0.8 1.2 8.5 0.0 2.2 2 0 0 2 2 2 2 Enterobacterial TraT complement resistance protein RicinB_lectin_2 PF14200.1 ESA22079.1 - 3e-12 46.8 0.7 5.6e-07 29.8 0.0 2.4 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA22079.1 - 2.5e-10 40.4 0.1 0.0014 18.6 0.0 3.0 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain BTB PF00651.26 ESA22080.1 - 1.3e-13 50.8 0.1 2.5e-13 49.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22080.1 - 2.7e-13 50.0 1.8 4.4e-13 49.4 0.3 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22080.1 - 3e-07 30.2 0.4 1.7e-06 27.8 0.1 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA22080.1 - 0.0079 15.3 0.2 0.013 14.6 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) CHZ PF09649.5 ESA22080.1 - 0.82 8.9 3.7 0.91 8.8 0.1 2.3 2 0 0 2 2 2 0 Histone chaperone domain CHZ BTB PF00651.26 ESA22081.1 - 7e-15 54.9 0.1 1.7e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22081.1 - 2.4e-12 47.0 6.4 2.5e-12 46.9 1.7 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22081.1 - 8.7e-10 38.3 8.5 5.3e-08 32.6 1.5 3.7 2 1 1 3 3 3 2 BTB And C-terminal Kelch DUF1767 PF08585.7 ESA22081.1 - 0.13 12.5 2.1 9.4 6.5 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1767) DUF3342 PF11822.3 ESA22081.1 - 0.41 9.7 3.5 0.18 10.9 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Sel1 PF08238.7 ESA22082.1 - 2.3e-58 193.3 38.4 2e-12 47.2 1.1 6.7 7 0 0 7 7 7 6 Sel1 repeat TPR_6 PF13174.1 ESA22082.1 - 1.4e-05 25.2 15.5 1.4 9.5 0.2 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_20 PF14561.1 ESA22082.1 - 0.00037 20.5 0.6 2.4 8.3 0.0 3.7 2 2 1 4 4 4 1 Tetratricopeptide repeat YlbE PF14003.1 ESA22082.1 - 0.0086 16.1 0.7 1.3 9.1 0.0 3.4 2 1 1 3 3 3 1 YlbE-like protein V-set PF07686.12 ESA22082.1 - 0.025 14.4 9.9 9.1 6.2 0.0 4.9 3 1 2 5 5 5 0 Immunoglobulin V-set domain MIT PF04212.13 ESA22082.1 - 0.076 12.9 25.0 2.1 8.2 0.3 6.0 4 2 1 5 5 5 0 MIT (microtubule interacting and transport) domain HTH_16 PF12645.2 ESA22082.1 - 0.082 12.8 1.6 4.5 7.2 0.1 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain Eco57I PF07669.6 ESA22083.1 - 0.091 13.1 0.1 0.56 10.5 0.0 2.2 2 0 0 2 2 2 0 Eco57I restriction-modification methylase CD99L2 PF12301.3 ESA22083.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 CD99 antigen like protein 2 SAC3_GANP PF03399.11 ESA22085.1 - 0.035 13.6 0.1 0.043 13.3 0.1 1.3 1 1 0 1 1 1 0 SAC3/GANP/Nin1/mts3/eIF-3 p25 family HHH_2 PF12826.2 ESA22085.1 - 0.096 12.5 0.0 0.69 9.8 0.0 2.1 1 1 1 2 2 2 0 Helix-hairpin-helix motif DNA_pol3_a_NII PF11490.3 ESA22085.1 - 0.81 9.3 4.5 5.1 6.7 0.6 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II TLD PF07534.11 ESA22086.1 - 1.4e-05 25.1 2.8 3.8e-05 23.6 2.0 1.7 1 1 0 1 1 1 1 TLD IL6Ra-bind PF09240.5 ESA22086.1 - 0.073 13.2 0.2 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding Pkinase PF00069.20 ESA22088.1 - 1.3e-24 86.7 0.1 1.6e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22088.1 - 3.7e-22 78.6 0.0 4.6e-22 78.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4361 PF14274.1 ESA22088.1 - 0.4 10.3 6.1 1.8 8.1 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4361) Pkinase_Tyr PF07714.12 ESA22091.1 - 5.2e-43 146.9 0.0 5.8e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22091.1 - 6.8e-37 127.0 0.0 7.8e-37 126.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA22091.1 - 0.00047 19.2 0.0 0.00053 19.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 ESA22091.1 - 0.00073 18.9 0.1 0.00098 18.5 0.1 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA22091.1 - 0.0034 17.1 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA22091.1 - 0.005 16.0 0.3 0.0074 15.5 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA22091.1 - 0.012 14.7 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Endotoxin_C PF03944.9 ESA22091.1 - 0.13 12.3 0.6 5.8 7.0 0.0 2.1 2 0 0 2 2 2 0 delta endotoxin DUF832 PF05734.6 ESA22093.1 - 0.014 14.6 0.3 0.033 13.3 0.1 1.7 2 0 0 2 2 2 0 Herpesvirus protein of unknown function (DUF832) UPF0128 PF03673.8 ESA22096.1 - 0.04 13.2 0.2 0.061 12.6 0.1 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0128) Rep_4 PF05797.6 ESA22096.1 - 0.064 11.9 0.3 0.071 11.8 0.2 1.2 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) Arch_ATPase PF01637.13 ESA22097.1 - 0.011 15.3 0.3 0.015 15.0 0.2 1.2 1 0 0 1 1 1 0 Archaeal ATPase Fe-ADH PF00465.14 ESA22097.1 - 0.12 10.9 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase TBCA PF02970.11 ESA22097.1 - 0.25 11.4 2.1 4.6 7.3 0.4 2.5 2 1 0 2 2 2 0 Tubulin binding cofactor A LRRNT_2 PF08263.7 ESA22098.1 - 0.001 19.0 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain FliT PF05400.8 ESA22099.1 - 0.0031 17.8 9.2 0.051 13.9 1.9 2.1 1 1 1 2 2 2 2 Flagellar protein FliT HSBP1 PF06825.7 ESA22099.1 - 0.0068 15.9 2.6 0.047 13.2 1.8 2.4 1 1 0 1 1 1 1 Heat shock factor binding protein 1 CHASE3 PF05227.8 ESA22099.1 - 0.096 12.3 2.2 0.1 12.2 0.5 1.8 1 1 0 1 1 1 0 CHASE3 domain Frankia_peptide PF14407.1 ESA22099.1 - 0.16 11.7 3.2 7.5 6.4 0.4 2.5 2 1 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. AHH PF14412.1 ESA22099.1 - 0.22 11.5 3.8 0.43 10.5 2.6 1.5 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH LXG PF04740.7 ESA22099.1 - 0.24 11.1 6.5 0.37 10.5 4.4 1.4 1 1 0 1 1 1 0 LXG domain of WXG superfamily FTA4 PF13093.1 ESA22099.1 - 0.33 10.3 7.5 0.44 9.9 5.2 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 ATP-synt_F6 PF05511.6 ESA22099.1 - 0.49 10.3 2.8 0.66 9.9 2.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 ETC_C1_NDUFA5 PF04716.9 ESA22099.1 - 0.52 9.8 0.1 0.52 9.8 0.1 3.1 2 1 1 3 3 3 0 ETC complex I subunit conserved region Ead_Ea22 PF13935.1 ESA22099.1 - 0.53 10.6 7.0 0.88 9.8 4.9 1.5 1 1 0 1 1 1 0 Ead/Ea22-like protein Strumpellin PF10266.4 ESA22099.1 - 0.72 7.1 4.7 0.83 6.9 3.3 1.0 1 0 0 1 1 1 0 Hereditary spastic paraplegia protein strumpellin APG6 PF04111.7 ESA22099.1 - 2.2 7.2 12.1 2.4 7.0 8.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 PaaSYMP PF14738.1 ESA22099.1 - 2.5 7.7 8.8 4.4 7.0 6.1 1.5 1 1 0 1 1 1 0 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 AAA_23 PF13476.1 ESA22099.1 - 7 6.9 17.5 8.6 6.6 12.1 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran_2 PF12848.2 ESA22099.1 - 8.3 6.3 12.2 29 4.5 0.2 3.3 1 1 2 3 3 3 0 ABC transporter HHA PF05321.6 ESA22099.1 - 8.4 6.6 6.5 20 5.3 0.3 3.0 2 1 1 3 3 3 0 Haemolysin expression modulating protein TLD PF07534.11 ESA22100.1 - 7.4e-13 48.6 0.8 1.7e-12 47.5 0.2 1.7 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA22100.1 - 2.5e-08 33.8 0.1 4.1e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Nodulin-like PF06813.8 ESA22101.1 - 1.1e-16 60.8 8.8 1.1e-16 60.8 6.1 2.2 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.11 ESA22101.1 - 7.1e-14 51.2 32.8 4.1e-10 38.9 12.8 2.6 1 1 0 2 2 2 2 Major Facilitator Superfamily HTH_OrfB_IS605 PF12323.3 ESA22103.1 - 1.3e-10 40.4 1.6 2.3e-10 39.6 1.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain CHD5 PF04420.9 ESA22103.1 - 0.16 11.6 2.5 0.21 11.2 0.3 1.8 2 0 0 2 2 2 0 CHD5-like protein zf-C2H2 PF00096.21 ESA22104.1 - 0.055 13.8 3.5 0.1 13.0 0.8 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Fringe PF02434.11 ESA22105.1 - 0.047 12.8 0.1 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Fringe-like FdhD-NarQ PF02634.10 ESA22109.1 - 0.07 12.5 0.1 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 FdhD/NarQ family HSF_DNA-bind PF00447.12 ESA22109.1 - 1.1 9.4 7.0 12 6.1 0.1 2.6 2 1 0 2 2 2 0 HSF-type DNA-binding DUF4508 PF14969.1 ESA22110.1 - 0.021 14.8 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) DUF4125 PF13526.1 ESA22111.1 - 0.024 14.1 0.3 0.028 13.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) YmaF PF12788.2 ESA22111.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 YmaF family Terminase_3 PF04466.8 ESA22112.1 - 0.038 13.0 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 Phage terminase large subunit FbpA PF05833.6 ESA22113.1 - 0.0079 14.7 0.8 0.008 14.7 0.5 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF848 PF05852.6 ESA22113.1 - 0.015 15.1 2.6 0.016 15.0 1.8 1.1 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) NPV_P10 PF05531.7 ESA22113.1 - 0.027 14.6 2.4 0.044 14.0 1.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF572 PF04502.8 ESA22113.1 - 0.054 12.7 3.5 0.06 12.5 2.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Cep57_CLD PF14073.1 ESA22113.1 - 0.11 12.3 6.5 0.12 12.1 4.5 1.2 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 HSBP1 PF06825.7 ESA22113.1 - 0.7 9.5 4.0 12 5.5 2.8 2.3 1 1 0 1 1 1 0 Heat shock factor binding protein 1 DUF342 PF03961.8 ESA22113.1 - 0.83 7.9 4.3 0.84 7.9 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1690 PF07956.6 ESA22113.1 - 3.3 7.7 9.8 6.7 6.6 6.8 1.7 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) AAA_23 PF13476.1 ESA22113.1 - 4.6 7.5 12.3 5.5 7.2 8.5 1.1 1 0 0 1 1 1 0 AAA domain USP8_dimer PF08969.6 ESA22113.1 - 4.7 7.1 8.4 5 7.1 1.8 2.4 1 1 1 2 2 2 0 USP8 dimerisation domain Imm22 PF15592.1 ESA22114.1 - 0.0031 17.8 1.3 0.0037 17.5 0.9 1.3 1 0 0 1 1 1 1 Immunity protein 22 Anp1 PF03452.9 ESA22114.1 - 0.029 13.5 1.1 0.028 13.5 0.7 1.1 1 0 0 1 1 1 0 Anp1 DUF592 PF04574.8 ESA22114.1 - 0.035 13.6 3.9 0.041 13.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF592) Glyco_transf_92 PF01697.22 ESA22114.1 - 0.042 13.1 0.2 0.089 12.0 0.2 1.5 1 1 0 1 1 1 0 Glycosyltransferase family 92 DUF2681 PF10883.3 ESA22114.1 - 0.053 13.7 3.0 0.097 12.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Pox_F11 PF04943.7 ESA22114.1 - 0.071 11.9 2.7 0.08 11.7 1.9 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein CENP-Q PF13094.1 ESA22114.1 - 0.12 12.4 7.9 0.14 12.2 5.5 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit RNA_pol_Rpb5_C PF01191.14 ESA22114.1 - 0.12 11.9 2.6 0.6 9.7 1.8 2.1 1 1 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Nif11 PF07862.6 ESA22114.1 - 0.12 12.2 3.6 8.9 6.3 0.3 2.6 1 1 1 2 2 2 0 Nitrogen fixation protein of unknown function DSX_dimer PF08828.5 ESA22114.1 - 0.15 11.5 6.8 0.26 10.8 0.2 3.0 2 1 0 2 2 2 0 Doublesex dimerisation domain AAA_23 PF13476.1 ESA22114.1 - 6.6 7.0 14.5 8.3 6.6 10.1 1.1 1 0 0 1 1 1 0 AAA domain YqzE PF14038.1 ESA22115.1 - 9 6.1 6.8 53 3.6 0.0 2.2 2 0 0 2 2 2 0 YqzE-like protein DDE_1 PF03184.14 ESA22117.1 - 1.5e-19 70.0 0.6 5.3e-18 64.9 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA22117.1 - 5.9e-10 38.8 1.5 9.8e-10 38.1 0.1 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA22117.1 - 4.1e-07 29.8 0.1 7.1e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease BTD PF09270.5 ESA22117.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Beta-trefoil DNA-binding domain DUF1973 PF09315.6 ESA22117.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1973) Nop14 PF04147.7 ESA22117.1 - 1 7.2 10.7 1.3 6.8 7.4 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.7 ESA22117.1 - 5.7 5.9 12.2 7.8 5.5 8.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDE_1 PF03184.14 ESA22118.1 - 1.9e-35 121.9 0.7 2.5e-35 121.5 0.5 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.1 ESA22118.1 - 2.2e-05 24.2 0.1 0.00015 21.5 0.1 2.1 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA22118.1 - 0.006 16.3 5.1 0.062 13.1 1.2 3.1 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain Tetraspannin PF00335.15 ESA22118.1 - 0.17 11.1 0.6 0.25 10.5 0.4 1.3 1 0 0 1 1 1 0 Tetraspanin family DDE_1 PF03184.14 ESA22119.1 - 8.5e-14 51.2 0.1 1.2e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA22119.1 - 1.9e-06 27.5 0.1 4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain zf-RING_5 PF14634.1 ESA22120.1 - 0.078 12.7 0.9 0.12 12.0 0.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Dimer_Tnp_hAT PF05699.9 ESA22126.1 - 1.8e-20 72.3 0.1 3e-20 71.6 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA22126.1 - 0.0036 17.2 0.0 0.0077 16.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) DUF848 PF05852.6 ESA22127.1 - 0.0038 17.0 1.7 0.0051 16.6 1.2 1.3 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) CALCOCO1 PF07888.6 ESA22127.1 - 0.0052 15.1 2.0 0.0066 14.7 1.4 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like SYCE1 PF15233.1 ESA22127.1 - 0.061 13.2 4.9 0.04 13.8 2.0 1.6 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 TMPIT PF07851.8 ESA22127.1 - 0.22 10.5 2.4 0.3 10.1 1.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.11 ESA22127.1 - 0.32 9.5 1.7 0.38 9.2 1.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.14 ESA22127.1 - 0.69 7.6 3.1 0.78 7.5 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc24 PF08286.6 ESA22127.1 - 1.7 8.3 7.1 2.7 7.7 5.0 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TLD PF07534.11 ESA22128.1 - 1.1e-11 44.9 1.7 1.2e-11 44.7 1.2 1.0 1 0 0 1 1 1 1 TLD RNA_POL_M_15KD PF02150.11 ESA22128.1 - 0.16 11.6 1.0 0.26 10.9 0.7 1.3 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit Mucin PF01456.12 ESA22129.1 - 0.037 13.8 13.7 0.057 13.1 9.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein GlutR_dimer PF00745.15 ESA22129.1 - 0.12 12.3 3.4 0.54 10.2 0.5 2.8 2 1 1 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain PMC2NT PF08066.7 ESA22129.1 - 0.29 11.4 4.2 0.32 11.3 0.1 2.6 1 1 2 3 3 3 0 PMC2NT (NUC016) domain DUF3533 PF12051.3 ESA22129.1 - 0.45 9.2 4.2 5.5 5.6 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3533) DUF327 PF03885.8 ESA22129.1 - 0.5 10.2 9.4 0.46 10.3 1.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF327) GLTP PF08718.6 ESA22129.1 - 2.6 8.0 7.0 14 5.6 4.9 2.4 1 1 0 1 1 1 0 Glycolipid transfer protein (GLTP) Vhr1 PF04001.8 ESA22130.1 - 0.068 13.0 3.8 1.7 8.6 2.6 2.5 1 1 0 1 1 1 0 Transcription factor Vhr1 SPX PF03105.14 ESA22130.1 - 0.18 11.5 8.0 0.26 11.0 5.5 1.3 1 1 0 1 1 1 0 SPX domain SH3_8 PF13457.1 ESA22130.1 - 0.86 9.8 5.0 0.2 11.8 0.8 1.9 3 0 0 3 3 3 0 SH3-like domain IncA PF04156.9 ESA22131.1 - 0.18 11.3 4.3 0.23 11.0 3.0 1.1 1 0 0 1 1 1 0 IncA protein DNA_pol_alpha_N PF12254.3 ESA22131.1 - 0.97 9.3 3.9 0.51 10.1 0.2 2.2 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal DUF3734 PF12536.3 ESA22131.1 - 2 8.5 5.3 6.8 6.8 0.4 2.2 1 1 1 2 2 2 0 Patatin phospholipase Cbl_N PF02262.11 ESA22131.1 - 2.1 8.0 6.3 0.38 10.4 0.8 2.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 Phage_GP20 PF06810.6 ESA22131.1 - 5.8 6.3 11.5 0.51 9.7 2.5 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 Atg14 PF10186.4 ESA22131.1 - 7 5.5 13.1 15 4.3 8.5 1.8 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 NEMO PF11577.3 ESA22131.1 - 8.4 6.2 8.1 0.57 9.9 1.8 1.9 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Mt_ATP-synt_D PF05873.7 ESA22132.1 - 0.057 13.0 0.8 0.12 11.9 0.5 1.6 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Allexi_40kDa PF05549.6 ESA22132.1 - 3.5 6.8 6.9 1.5 8.0 2.7 1.8 1 1 1 2 2 2 0 Allexivirus 40kDa protein BTB PF00651.26 ESA22134.1 - 4.5e-19 68.4 1.2 7.9e-19 67.6 0.1 2.0 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA22134.1 - 1.5e-11 44.4 3.4 4.4e-11 42.9 2.3 1.9 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22134.1 - 6.3e-08 32.3 0.2 6.6e-06 25.9 0.0 3.3 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA22134.1 - 0.01 14.9 0.4 0.017 14.2 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) IceA2 PF05862.6 ESA22135.1 - 0.033 13.9 0.1 0.096 12.4 0.1 1.8 1 0 0 1 1 1 0 Helicobacter pylori IceA2 protein Bac_DnaA PF00308.13 ESA22136.1 - 0.0011 18.6 0.0 0.0039 16.8 0.0 1.9 2 0 0 2 2 2 1 Bacterial dnaA protein Arch_ATPase PF01637.13 ESA22136.1 - 0.0015 18.2 1.2 0.0071 16.0 0.2 2.4 1 1 1 2 2 2 1 Archaeal ATPase NACHT PF05729.7 ESA22136.1 - 0.093 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.12 ESA22136.1 - 0.1 12.0 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ArgK PF03308.11 ESA22136.1 - 0.22 10.2 0.0 0.42 9.3 0.0 1.4 1 0 0 1 1 1 0 ArgK protein Bac_DnaA PF00308.13 ESA22137.1 - 0.001 18.7 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial dnaA protein Arch_ATPase PF01637.13 ESA22137.1 - 0.0034 17.1 0.1 0.011 15.4 0.1 2.1 1 1 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 ESA22137.1 - 0.022 14.4 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.12 ESA22137.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DAP3 PF10236.4 ESA22137.1 - 0.18 10.6 3.1 3.6 6.4 0.0 2.9 3 1 1 4 4 4 0 Mitochondrial ribosomal death-associated protein 3 DUF2080 PF09853.4 ESA22137.1 - 0.23 11.2 1.2 1.5 8.6 0.1 2.5 2 0 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) ATP_bind_1 PF03029.12 ESA22137.1 - 0.51 9.8 3.8 1.7 8.0 1.1 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein HSDR_N PF04313.9 ESA22140.1 - 0.018 14.8 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N_2 PF13588.1 ESA22140.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Transket_pyr PF02779.19 ESA22141.1 - 2.9e-62 209.3 0.0 4.5e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 ESA22141.1 - 1.7e-42 145.1 0.0 3.6e-42 144.1 0.0 1.5 2 0 0 2 2 2 1 Dehydrogenase E1 component zf-CpG_bind_C PF12269.3 ESA22142.1 - 8.2e-06 25.4 2.2 1e-05 25.1 1.5 1.1 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain TSC22 PF01166.13 ESA22142.1 - 0.0018 18.1 5.9 0.0018 18.1 4.1 2.4 1 1 1 2 2 2 1 TSC-22/dip/bun family Fmp27_WPPW PF10359.4 ESA22142.1 - 0.0028 16.1 5.1 0.003 16.0 3.6 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain CENP-F_leu_zip PF10473.4 ESA22142.1 - 0.033 14.0 10.4 0.055 13.3 7.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Shugoshin_N PF07558.6 ESA22142.1 - 0.11 12.2 5.1 0.12 12.1 0.4 2.3 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region IncA PF04156.9 ESA22142.1 - 0.14 11.7 6.2 0.17 11.4 4.3 1.2 1 0 0 1 1 1 0 IncA protein Mnd1 PF03962.10 ESA22142.1 - 0.16 11.6 4.4 0.22 11.1 3.0 1.3 1 0 0 1 1 1 0 Mnd1 family 4HB_MCP_1 PF12729.2 ESA22142.1 - 0.29 10.4 4.8 0.39 10.0 3.3 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction bZIP_1 PF00170.16 ESA22142.1 - 0.29 11.1 12.2 0.73 9.8 2.6 2.3 1 1 1 2 2 2 0 bZIP transcription factor DUF3818 PF12825.2 ESA22142.1 - 0.33 9.5 5.1 0.37 9.4 3.5 1.0 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) DUF972 PF06156.8 ESA22142.1 - 0.35 11.2 11.5 0.54 10.6 6.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF972) CENP-H PF05837.7 ESA22142.1 - 0.36 11.0 6.6 0.68 10.1 4.6 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) bZIP_2 PF07716.10 ESA22142.1 - 0.45 10.3 14.1 0.39 10.5 2.0 2.5 1 1 1 2 2 2 0 Basic region leucine zipper M PF02370.11 ESA22142.1 - 0.49 10.9 16.2 0.19 12.1 1.9 3.3 3 0 0 3 3 2 0 M protein repeat Striatin PF08232.7 ESA22142.1 - 0.59 10.4 10.0 1.6 9.0 6.9 1.8 1 1 0 1 1 1 0 Striatin family DivIC PF04977.10 ESA22142.1 - 0.86 9.1 11.8 0.38 10.2 3.7 2.3 1 1 1 2 2 2 0 Septum formation initiator Ax_dynein_light PF10211.4 ESA22142.1 - 2.5 7.8 10.3 3.9 7.2 6.3 1.8 1 1 1 2 2 2 0 Axonemal dynein light chain NYD-SP28_assoc PF14775.1 ESA22142.1 - 7.3 6.3 9.1 12 5.6 2.1 2.5 1 1 1 2 2 2 0 Sperm tail C-terminal domain MerR-DNA-bind PF09278.6 ESA22142.1 - 7.5 7.0 9.3 6.8 7.1 1.9 2.2 1 1 1 2 2 2 0 MerR, DNA binding SYCE1 PF15233.1 ESA22145.1 - 0.031 14.2 0.4 0.036 13.9 0.3 1.1 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Lipase_GDSL PF00657.17 ESA22147.1 - 3.4e-07 30.3 0.7 1.2e-06 28.4 0.1 1.9 1 1 1 2 2 2 1 GDSL-like Lipase/Acylhydrolase BTB PF00651.26 ESA22148.1 - 5.7e-18 64.9 0.2 1.5e-17 63.5 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA22148.1 - 6.3e-09 35.6 2.8 1.6e-08 34.3 0.2 2.7 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF1841 PF08897.6 ESA22148.1 - 0.07 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) BTB PF00651.26 ESA22149.1 - 5.8e-18 64.9 0.0 1.5e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22149.1 - 4.5e-15 55.8 2.7 4.5e-15 55.8 1.8 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22149.1 - 4.9e-07 29.5 0.7 2.9e-06 27.0 0.2 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA22150.1 - 3.2e-17 62.4 0.1 6.1e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22150.1 - 4.9e-15 55.7 0.9 4.9e-15 55.7 0.7 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22150.1 - 4.5e-06 26.4 5.7 2.8e-05 23.8 0.2 4.0 4 1 1 5 5 5 1 BTB And C-terminal Kelch TLD PF07534.11 ESA22151.1 - 3.4e-16 59.4 2.5 5e-16 58.9 1.7 1.3 1 0 0 1 1 1 1 TLD TLD PF07534.11 ESA22153.1 - 4.7e-18 65.5 0.7 1.1e-17 64.3 0.5 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA22153.1 - 0.00018 21.2 2.5 0.0013 18.5 0.3 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch Autotrns_rpt PF12951.2 ESA22153.1 - 0.0051 16.4 1.2 0.01 15.5 0.8 1.4 1 0 0 1 1 1 1 Autotransporter-associated beta strand repeat Sec34 PF04136.10 ESA22153.1 - 0.0053 16.4 3.8 0.24 11.0 0.1 2.5 2 0 0 2 2 2 2 Sec34-like family IncA PF04156.9 ESA22153.1 - 1.6 8.2 5.6 3.3 7.2 3.9 1.5 1 0 0 1 1 1 0 IncA protein Pkinase PF00069.20 ESA22154.1 - 1.8e-47 161.7 0.0 2.2e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22154.1 - 7.4e-46 156.3 0.0 8.9e-46 156.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA22154.1 - 0.0027 17.0 0.2 0.014 14.7 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.9 ESA22154.1 - 0.0029 16.7 0.1 0.0043 16.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA22154.1 - 0.014 15.1 0.2 0.04 13.6 0.2 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA22154.1 - 0.022 13.9 0.1 0.045 12.9 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA22154.1 - 0.052 12.8 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL efThoc1 PF11957.3 ESA22155.1 - 0.11 10.9 0.6 0.14 10.6 0.4 1.0 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor CD20 PF04103.10 ESA22157.1 - 0.0017 18.3 2.9 0.0017 18.3 2.0 2.3 1 1 1 2 2 2 1 CD20-like family DUF2417 PF10329.4 ESA22157.1 - 0.16 11.3 0.1 0.16 11.3 0.1 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) Tetraspannin PF00335.15 ESA22157.1 - 1.5 8.0 8.6 1.3 8.2 5.3 1.4 1 1 0 1 1 1 0 Tetraspanin family DUF2306 PF10067.4 ESA22157.1 - 6.1 7.0 8.8 5.6 7.1 3.9 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2306) Sel1 PF08238.7 ESA22163.1 - 2e-22 79.0 8.9 2.5e-07 31.0 0.3 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_11 PF13414.1 ESA22163.1 - 0.022 14.4 5.1 0.93 9.1 0.2 3.1 2 1 1 3 3 3 0 TPR repeat Sec66 PF09802.4 ESA22163.1 - 0.15 11.4 0.2 2.2 7.6 0.0 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 DUF2989 PF11207.3 ESA22163.1 - 0.84 9.0 4.3 2.8 7.3 0.4 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2989) Alpha_E3_glycop PF01563.11 ESA22164.1 - 0.093 12.5 0.9 0.83 9.5 0.3 2.2 2 0 0 2 2 2 0 Alphavirus E3 glycoprotein Git3 PF11710.3 ESA22165.1 - 0.046 13.2 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 NOD PF06816.8 ESA22165.1 - 0.12 11.4 0.0 0.59 9.2 0.0 2.1 2 0 0 2 2 2 0 NOTCH protein Dynamin_N PF00350.18 ESA22166.1 - 9.6e-41 139.3 0.2 1.5e-26 93.2 0.0 2.4 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.18 ESA22166.1 - 2.6e-10 40.2 0.0 4.7e-05 23.3 0.0 3.3 2 2 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 ESA22166.1 - 1.3e-07 32.1 0.0 0.013 16.0 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein ABC_tran PF00005.22 ESA22166.1 - 7.3e-05 23.0 0.0 0.45 10.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter Arch_ATPase PF01637.13 ESA22166.1 - 0.00011 21.9 0.1 0.23 11.1 0.0 2.9 3 0 0 3 3 3 2 Archaeal ATPase AAA_16 PF13191.1 ESA22166.1 - 0.00012 22.0 0.0 0.36 10.7 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain SRPRB PF09439.5 ESA22166.1 - 0.0003 20.0 0.0 0.69 9.1 0.0 3.1 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 ESA22166.1 - 0.0006 19.3 0.0 6.6 6.1 0.0 3.7 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 ESA22166.1 - 0.00065 19.1 0.0 0.52 9.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 ESA22166.1 - 0.00073 19.0 0.0 0.48 9.8 0.0 3.1 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_21 PF13304.1 ESA22166.1 - 0.0046 16.9 0.1 2.1 8.2 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_28 PF13521.1 ESA22166.1 - 0.011 15.6 0.0 5.1 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 ESA22166.1 - 0.012 15.9 0.0 2.5 8.4 0.0 3.0 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.13 ESA22166.1 - 0.013 14.7 1.2 16 4.7 0.0 3.6 4 0 0 4 4 4 0 Ferrous iron transport protein B ETF PF01012.16 ESA22166.1 - 0.017 14.8 0.0 5.8 6.6 0.0 2.7 2 0 0 2 2 2 0 Electron transfer flavoprotein domain PRK PF00485.13 ESA22166.1 - 0.018 14.5 0.0 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family PduV-EutP PF10662.4 ESA22166.1 - 0.022 14.2 0.8 14 5.1 0.0 3.8 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 ESA22166.1 - 0.033 14.3 0.0 10 6.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 ESA22166.1 - 0.059 13.0 0.6 5.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 ESA22166.1 - 0.062 13.6 8.0 2.4 8.4 2.2 3.3 2 2 0 2 2 2 0 AAA domain NACHT PF05729.7 ESA22166.1 - 0.087 12.4 0.0 7.2 6.2 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.1 ESA22166.1 - 0.1 13.4 0.0 15 6.4 0.0 3.3 3 1 0 3 3 3 0 AAA domain AAA_33 PF13671.1 ESA22166.1 - 0.15 11.9 0.0 9.5 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Ras PF00071.17 ESA22166.1 - 0.16 11.3 0.0 17 4.7 0.0 2.4 2 0 0 2 2 2 0 Ras family Dynamin_N PF00350.18 ESA22167.1 - 1.4e-18 67.2 0.0 2.2e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 ESA22167.1 - 0.00036 20.4 0.1 0.0025 17.7 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA22167.1 - 0.0051 16.2 0.1 0.54 9.6 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Miro PF08477.8 ESA22167.1 - 0.065 13.7 0.6 0.15 12.5 0.1 2.0 2 1 0 2 2 2 0 Miro-like protein Radical_SAM PF04055.16 ESA22168.1 - 2.8e-12 47.1 0.0 1.3e-11 44.9 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.14 ESA22168.1 - 0.00059 19.7 0.0 0.13 12.1 0.0 2.6 3 0 0 3 3 3 2 B12 binding domain ALMS_motif PF15309.1 ESA22168.1 - 0.0053 16.6 0.5 0.01 15.6 0.4 1.4 1 0 0 1 1 1 1 ALMS motif Fer4_12 PF13353.1 ESA22168.1 - 0.013 15.5 0.2 3.5 7.7 0.0 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain AP_endonuc_2 PF01261.19 ESA22168.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel RNase_H PF00075.19 ESA22174.1 - 1.2e-11 45.0 0.0 2.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 RNase H Sel1 PF08238.7 ESA22175.1 - 8.3e-35 118.4 10.5 2.4e-08 34.3 0.1 5.6 5 1 1 6 6 6 5 Sel1 repeat TPR_6 PF13174.1 ESA22175.1 - 0.037 14.4 3.9 33 5.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.13 ESA22175.1 - 0.061 13.2 4.3 13 5.7 0.6 3.7 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA22175.1 - 0.11 12.1 6.1 2.5 7.8 0.0 3.5 2 1 0 3 3 3 0 TPR repeat TPR_7 PF13176.1 ESA22175.1 - 0.12 12.2 0.3 3.7 7.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22175.1 - 0.15 11.9 1.4 26 4.8 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.15 ESA22175.1 - 0.18 11.8 0.2 0.18 11.8 0.2 3.4 4 0 0 4 4 4 0 PPR repeat TPR_2 PF07719.12 ESA22175.1 - 3.5 7.7 14.7 3.4 7.8 0.0 4.8 7 0 0 7 7 7 0 Tetratricopeptide repeat RNase_H PF00075.19 ESA22176.1 - 4.7e-11 43.1 0.0 1.4e-10 41.6 0.0 1.8 1 1 0 1 1 1 1 RNase H ERAP1_C PF11838.3 ESA22176.1 - 0.00018 20.8 0.1 0.00036 19.8 0.0 1.5 2 0 0 2 2 2 1 ERAP1-like C-terminal domain DUF1542 PF07564.6 ESA22178.1 - 0.11 12.5 1.3 0.79 9.7 0.1 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF722 PF05263.6 ESA22179.1 - 0.11 12.6 0.5 0.14 12.3 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF722) Pkinase PF00069.20 ESA22180.1 - 1.8e-24 86.3 0.1 2.4e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22180.1 - 2.2e-21 76.1 0.0 2.7e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA22180.1 - 0.0018 17.3 0.0 0.0029 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3647 PF12363.3 ESA22180.1 - 0.027 14.5 0.1 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 Phage protein GKAP PF03359.8 ESA22180.1 - 0.059 12.9 0.5 0.088 12.4 0.3 1.3 1 1 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Pkinase PF00069.20 ESA22181.1 - 1.8e-21 76.4 0.1 3.4e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22181.1 - 3.6e-19 68.8 0.0 5.4e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TLD PF07534.11 ESA22182.1 - 6.4e-16 58.6 3.1 1.7e-15 57.2 1.1 2.2 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA22182.1 - 2.7e-15 56.3 0.3 4.7e-15 55.5 0.2 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22182.1 - 4.6e-07 29.6 4.8 8.2e-05 22.3 0.3 3.9 2 1 2 4 4 4 2 BTB And C-terminal Kelch MULE PF10551.4 ESA22184.1 - 2.2e-08 34.1 0.0 5.9e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain Cytochrom_c3_2 PF14537.1 ESA22185.1 - 0.0023 18.2 0.5 0.003 17.8 0.3 1.2 1 0 0 1 1 1 1 Cytochrome c3 DUF3945 PF13101.1 ESA22185.1 - 0.069 12.4 0.0 0.24 10.6 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3945) Peptidase_S8 PF00082.17 ESA22186.1 - 1.1e-42 146.1 0.9 1.4e-42 145.8 0.7 1.1 1 0 0 1 1 1 1 Subtilase family Pkinase PF00069.20 ESA22190.1 - 5.5e-12 45.3 0.1 5.7e-12 45.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22190.1 - 1e-08 34.5 0.0 1.1e-08 34.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Linker_histone PF00538.14 ESA22191.1 - 5.4e-23 80.8 0.2 8.4e-23 80.2 0.1 1.3 1 0 0 1 1 1 1 linker histone H1 and H5 family DUF126 PF01989.11 ESA22191.1 - 0.026 14.2 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF126 DNA_pol_B_2 PF03175.8 ESA22192.1 - 0.0025 16.5 0.0 0.0025 16.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral Omega-toxin PF06357.6 ESA22194.1 - 3.6 7.2 10.5 11 5.6 7.3 1.9 1 1 0 1 1 1 0 Omega-atracotoxin DUF2603 PF10788.4 ESA22195.1 - 0.027 14.2 0.9 0.03 14.0 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2603) Pkinase_Tyr PF07714.12 ESA22196.1 - 8.7e-35 120.0 0.0 1.2e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22196.1 - 1.2e-31 109.7 0.0 1.8e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA22196.1 - 3.8e-05 23.5 0.0 5.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA22196.1 - 0.0016 17.6 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA22196.1 - 0.0018 17.4 0.0 0.0026 16.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 ESA22196.1 - 0.017 14.7 0.5 3 7.3 0.1 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.17 ESA22196.1 - 0.051 12.9 0.0 0.085 12.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family RAG1 PF12940.2 ESA22199.1 - 0.074 11.3 0.0 0.36 9.1 0.0 1.8 1 1 1 2 2 2 0 Recombination-activation protein 1 (RAG1) ZapA PF05164.8 ESA22199.1 - 0.082 12.8 0.0 13 5.8 0.0 2.2 2 0 0 2 2 2 0 Cell division protein ZapA TLD PF07534.11 ESA22201.1 - 9.2e-10 38.6 0.4 1.1e-09 38.3 0.3 1.2 1 1 0 1 1 1 1 TLD F-box-like PF12937.2 ESA22202.1 - 3.3e-05 23.4 0.1 0.0001 21.9 0.1 1.8 1 0 0 1 1 1 1 F-box-like BTB PF00651.26 ESA22203.1 - 5.2e-06 26.4 0.0 5.5e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22204.1 - 3.8e-10 39.8 4.6 6e-06 26.2 1.8 2.6 2 0 0 2 2 2 2 TLD BACK PF07707.10 ESA22204.1 - 7.4e-05 22.5 0.0 0.0011 18.7 0.1 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch NmrA PF05368.8 ESA22205.1 - 8.2e-51 172.4 0.0 9.4e-51 172.3 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA22205.1 - 4.1e-09 36.7 0.0 5.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 ESA22205.1 - 1.8e-05 23.6 0.0 2.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 ESA22205.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 ESA22205.1 - 0.017 15.0 0.1 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Epimerase PF01370.16 ESA22205.1 - 0.018 14.4 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 ESA22205.1 - 0.13 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Vps4_C PF09336.5 ESA22206.1 - 0.079 12.8 0.3 0.65 9.9 0.1 2.3 2 1 1 3 3 3 0 Vps4 C terminal oligomerisation domain DUF4413 PF14372.1 ESA22207.1 - 0.037 14.0 0.0 0.056 13.4 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4413) Ufm1 PF03671.9 ESA22207.1 - 0.057 13.1 0.0 0.07 12.8 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin fold modifier 1 protein MULE PF10551.4 ESA22208.1 - 5e-12 45.8 0.0 1.2e-11 44.5 0.0 1.6 2 0 0 2 2 2 1 MULE transposase domain Transposase_mut PF00872.13 ESA22208.1 - 0.0078 14.8 0.0 0.012 14.1 0.0 1.2 1 0 0 1 1 1 1 Transposase, Mutator family HTH_Crp_2 PF13545.1 ESA22210.1 - 0.12 12.2 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain BTB PF00651.26 ESA22212.1 - 1.5e-18 66.8 0.6 2.1e-17 63.1 0.0 2.6 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA22212.1 - 8.1e-10 38.4 0.7 4.8e-08 32.7 0.1 2.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA22212.1 - 5.4e-09 36.1 4.9 5.4e-09 36.1 3.4 1.9 2 0 0 2 2 2 1 TLD Pkinase_Tyr PF07714.12 ESA22213.1 - 0.00075 18.6 0.0 0.0013 17.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase SWIRM PF04433.12 ESA22213.1 - 0.032 14.3 0.3 0.075 13.1 0.1 1.8 2 0 0 2 2 2 0 SWIRM domain NAD_binding_10 PF13460.1 ESA22215.1 - 0.025 14.5 0.0 0.045 13.7 0.0 1.6 1 1 0 1 1 1 0 NADH(P)-binding Ins_P5_2-kin PF06090.7 ESA22216.1 - 1.4e-62 211.5 2.3 1.8e-62 211.2 1.6 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase CBFD_NFYB_HMF PF00808.18 ESA22217.1 - 1.2e-16 60.5 0.4 3.6e-16 58.9 0.3 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 ESA22217.1 - 1.1e-09 38.2 0.1 2.7e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RepA_C PF04796.7 ESA22217.1 - 1.7 8.2 9.6 0.055 13.0 0.5 2.4 3 0 0 3 3 3 0 Plasmid encoded RepA protein Lipase_GDSL_3 PF14606.1 ESA22217.1 - 5.4 6.7 8.3 0.39 10.4 1.6 2.1 3 0 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase family MMR_HSR1 PF01926.18 ESA22219.1 - 3.2e-05 23.8 3.2 3.2e-05 23.8 2.2 2.9 3 1 0 3 3 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA22219.1 - 8.1e-05 21.8 2.5 0.031 13.3 0.1 3.1 2 0 0 2 2 2 2 AIG1 family DUF258 PF03193.11 ESA22219.1 - 0.00095 18.3 0.3 0.0035 16.5 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA22219.1 - 0.0022 17.5 0.3 0.0066 15.9 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.1 ESA22219.1 - 0.0076 16.2 0.1 0.039 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 ESA22219.1 - 0.016 15.0 0.9 0.016 15.0 0.6 4.0 4 1 0 4 4 3 0 Dynamin family FtsK_SpoIIIE PF01580.13 ESA22219.1 - 0.025 14.0 0.1 0.055 12.9 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family SRP54 PF00448.17 ESA22219.1 - 0.026 13.9 1.9 3.6 6.9 0.2 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.1 ESA22219.1 - 0.038 13.9 1.0 0.34 10.8 0.0 2.9 4 0 0 4 4 4 0 AAA ATPase domain AAA_19 PF13245.1 ESA22219.1 - 0.055 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Part of AAA domain ABC_tran PF00005.22 ESA22219.1 - 0.071 13.4 0.0 0.071 13.4 0.0 3.5 3 1 0 3 3 2 0 ABC transporter AAA PF00004.24 ESA22219.1 - 0.13 12.4 0.1 0.13 12.4 0.1 3.1 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Cgr1 PF03879.9 ESA22219.1 - 0.24 11.5 3.4 0.76 9.9 0.3 2.9 2 0 0 2 2 2 0 Cgr1 family Miro PF08477.8 ESA22219.1 - 0.36 11.3 3.3 0.7 10.4 0.0 3.2 4 0 0 4 4 3 0 Miro-like protein IncA PF04156.9 ESA22219.1 - 0.58 9.7 14.0 0.15 11.6 1.2 3.2 3 0 0 3 3 3 0 IncA protein HrpB7 PF09486.5 ESA22219.1 - 0.71 9.7 4.1 0.8 9.6 0.2 2.4 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) BetaGal_dom2 PF10435.4 ESA22220.1 - 0.25 10.6 2.8 9.3 5.5 0.0 2.1 1 1 1 2 2 2 0 Beta-galactosidase, domain 2 Stc1 PF12898.2 ESA22220.1 - 2.4 8.3 9.2 3.3 7.8 6.4 1.2 1 0 0 1 1 1 0 Stc1 domain Siah-Interact_N PF09032.6 ESA22220.1 - 7.9 6.6 9.6 3.1 7.9 3.8 1.9 1 1 1 2 2 2 0 Siah interacting protein, N terminal Kelch_5 PF13854.1 ESA22221.1 - 8.7e-19 67.0 4.8 0.0067 16.3 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA22221.1 - 1.5e-15 56.6 11.4 0.0035 17.4 0.0 6.3 5 1 1 6 6 6 3 Kelch motif Kelch_4 PF13418.1 ESA22221.1 - 3.4e-14 52.3 20.4 0.00012 21.7 0.0 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA22221.1 - 1.5e-09 37.7 11.4 0.013 15.6 0.4 6.7 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA22221.1 - 1.4e-05 24.6 6.9 0.059 13.1 0.0 5.6 6 2 0 6 6 6 2 Kelch motif Kelch_1 PF01344.20 ESA22221.1 - 0.002 17.6 9.9 0.064 12.7 0.0 4.8 4 1 0 4 4 4 2 Kelch motif Astacin PF01400.19 ESA22222.1 - 1.4e-09 37.6 1.5 1.6e-05 24.3 0.4 3.0 1 1 1 2 2 2 2 Astacin (Peptidase family M12A) Astacin PF01400.19 ESA22223.1 - 5.3e-17 61.8 0.0 6.3e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) DUF2746 PF10874.3 ESA22224.1 - 0.5 10.5 5.6 1.5 9.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) DUF2743 PF10899.3 ESA22224.1 - 1.4 8.2 5.7 1.6 8.0 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2743) Complex1_LYR_2 PF13233.1 ESA22224.1 - 3.8 8.0 8.4 5.2 7.5 5.8 1.3 1 0 0 1 1 1 0 Complex1_LYR-like Arrestin_N PF00339.24 ESA22225.1 - 1.1e-14 54.5 0.9 2.2e-11 43.7 0.1 3.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 ESA22225.1 - 9.3e-14 51.7 6.7 2.8e-09 37.2 2.9 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.6 ESA22225.1 - 4.1e-06 26.3 0.1 0.0059 15.9 0.1 2.2 2 0 0 2 2 2 2 SpoOM protein Cpn60_TCP1 PF00118.19 ESA22226.1 - 5.7e-121 404.4 7.2 6.5e-121 404.3 5.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn10 PF00166.16 ESA22227.1 - 1.9e-28 98.2 0.2 2.2e-28 98.0 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit SPA PF08616.5 ESA22228.1 - 1.8e-12 46.9 0.2 3.6e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 ESA22228.1 - 1.5e-06 26.9 0.0 4.6e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 Transport protein Avl9 DENN PF02141.16 ESA22228.1 - 0.026 14.2 1.9 0.038 13.6 0.1 2.2 2 1 0 2 2 2 0 DENN (AEX-3) domain Pex2_Pex12 PF04757.9 ESA22229.1 - 3.7e-34 118.1 8.5 5.5e-34 117.5 5.9 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.20 ESA22229.1 - 0.00043 19.8 8.0 0.00072 19.1 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA22229.1 - 0.0021 18.0 6.3 0.017 15.1 4.4 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA22229.1 - 0.0022 17.8 3.0 0.0022 17.8 2.1 1.7 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 ESA22229.1 - 0.0036 16.9 7.0 0.0058 16.3 4.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESA22229.1 - 0.0058 16.4 6.0 0.012 15.3 4.1 1.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA22229.1 - 0.049 13.3 4.2 0.092 12.4 2.9 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA22229.1 - 0.089 12.5 4.2 0.2 11.3 2.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger OB_NTP_bind PF07717.11 ESA22230.1 - 1.7e-24 85.8 0.0 8.2e-23 80.4 0.0 2.4 1 1 1 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESA22230.1 - 4.7e-23 81.1 0.0 9.9e-23 80.0 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESA22230.1 - 3.9e-16 58.6 0.0 1e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 ESA22230.1 - 0.00012 22.2 0.0 0.00026 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 ESA22230.1 - 0.00092 18.7 0.2 0.0051 16.3 0.1 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase ABC_tran PF00005.22 ESA22230.1 - 0.015 15.6 0.1 0.049 13.9 0.1 2.0 1 1 0 1 1 1 0 ABC transporter DUF258 PF03193.11 ESA22230.1 - 0.044 12.9 0.0 0.082 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_14 PF13173.1 ESA22230.1 - 0.068 13.0 0.1 0.55 10.1 0.1 2.3 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA22230.1 - 0.084 11.7 0.1 0.19 10.5 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.1 ESA22230.1 - 0.12 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.1 ESA22230.1 - 0.16 11.3 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain HTH_Tnp_Tc5 PF03221.11 ESA22232.1 - 0.00017 21.3 0.2 0.34 10.7 0.0 2.5 2 0 0 2 2 2 2 Tc5 transposase DNA-binding domain Pro-NT_NN PF07421.6 ESA22233.1 - 0.57 9.6 3.4 0.95 8.9 0.1 1.9 1 1 1 2 2 2 0 Neurotensin/neuromedin N precursor TLD PF07534.11 ESA22234.1 - 3.2e-09 36.8 2.2 4.2e-09 36.5 1.5 1.2 1 0 0 1 1 1 1 TLD FWWh PF14922.1 ESA22236.1 - 0.033 13.6 0.4 0.28 10.6 0.3 2.4 1 1 0 1 1 1 0 Protein of unknown function DivIC PF04977.10 ESA22236.1 - 0.077 12.4 0.1 0.077 12.4 0.1 4.6 2 1 1 4 4 4 0 Septum formation initiator Lipoprotein_20 PF13942.1 ESA22236.1 - 0.2 11.1 4.6 0.12 11.8 1.0 2.3 2 1 0 2 2 2 0 YfhG lipoprotein BLOC1_2 PF10046.4 ESA22236.1 - 0.44 10.7 9.9 0.13 12.4 1.2 3.7 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2956 PF11169.3 ESA22236.1 - 0.72 9.8 6.1 0.58 10.1 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) TSC22 PF01166.13 ESA22236.1 - 0.81 9.6 0.1 0.81 9.6 0.0 3.3 4 0 0 4 4 4 0 TSC-22/dip/bun family IncA PF04156.9 ESA22236.1 - 1.8 8.1 11.3 2.7 7.5 5.8 2.5 2 0 0 2 2 2 0 IncA protein DUF972 PF06156.8 ESA22236.1 - 1.8 8.9 12.7 0.055 13.8 2.0 3.3 3 2 0 3 3 3 0 Protein of unknown function (DUF972) CM_2 PF01817.16 ESA22236.1 - 2.6 8.2 10.8 1.5 9.0 1.1 3.4 3 1 0 3 3 3 0 Chorismate mutase type II Atg14 PF10186.4 ESA22236.1 - 3.4 6.5 14.3 0.075 11.9 4.6 2.1 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 TLD PF07534.11 ESA22239.1 - 5e-15 55.7 2.0 5.6e-15 55.5 1.4 1.0 1 0 0 1 1 1 1 TLD Peptidase_C37 PF05416.7 ESA22240.1 - 0.11 10.8 0.0 0.11 10.8 0.0 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DUF1129 PF06570.6 ESA22241.1 - 0.098 11.9 4.0 0.16 11.2 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) FOLN PF09289.5 ESA22242.1 - 0.3 10.9 3.8 0.76 9.6 2.6 1.7 1 0 0 1 1 1 0 Follistatin/Osteonectin-like EGF domain Defensin_beta PF00711.14 ESA22242.1 - 0.73 9.8 4.1 5.6 6.9 0.0 2.5 1 1 1 2 2 2 0 Beta defensin HMG_box PF00505.14 ESA22243.1 - 3e-06 27.3 0.4 9.8e-06 25.7 0.3 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA22243.1 - 0.0022 18.3 0.1 0.0022 18.3 0.1 1.8 2 0 0 2 2 2 1 HMG-box domain 14-3-3 PF00244.15 ESA22243.1 - 0.0032 16.5 1.3 0.0054 15.8 0.9 1.4 1 0 0 1 1 1 1 14-3-3 protein RVT_1 PF00078.22 ESA22244.1 - 0.0045 16.3 0.3 0.009 15.3 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) T4SS PF07996.6 ESA22244.1 - 0.16 11.8 1.8 0.25 11.1 1.2 1.3 1 0 0 1 1 1 0 Type IV secretion system proteins Pox_A31 PF05771.6 ESA22244.1 - 0.18 11.6 5.4 0.18 11.6 1.9 2.2 1 1 1 2 2 2 0 Poxvirus A31 protein BCS1_N PF08740.6 ESA22245.1 - 0.00091 18.8 0.1 2 7.9 0.0 2.9 2 0 0 2 2 2 2 BCS1 N terminal PA14_2 PF10528.4 ESA22245.1 - 0.059 13.3 8.6 1 9.3 0.6 4.1 4 0 0 4 4 4 0 GLEYA domain FAD_binding_4 PF01565.18 ESA22247.1 - 3.5e-29 101.0 0.4 5.3e-29 100.4 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.7 ESA22247.1 - 1.7e-18 66.2 4.0 1.7e-18 66.2 2.8 2.2 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.5 ESA22247.1 - 0.00047 19.3 0.3 0.00079 18.6 0.2 1.3 1 0 0 1 1 1 1 Cytokinin dehydrogenase 1, FAD and cytokinin binding NPV_P10 PF05531.7 ESA22248.1 - 0.0034 17.5 0.2 0.29 11.4 0.0 3.6 3 0 0 3 3 3 1 Nucleopolyhedrovirus P10 protein DUF3139 PF11337.3 ESA22248.1 - 8 6.8 14.4 0.16 12.2 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Kelch_2 PF07646.10 ESA22249.1 - 9.4e-12 44.2 1.4 0.0078 15.9 0.0 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 ESA22249.1 - 2e-08 34.0 9.8 0.06 13.5 0.0 5.1 2 1 2 4 4 4 4 Kelch motif Kelch_1 PF01344.20 ESA22249.1 - 4.6e-08 32.4 4.1 0.023 14.2 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.1 ESA22249.1 - 4.7e-08 32.8 4.9 0.23 11.4 0.0 4.9 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA22249.1 - 5.2e-07 29.3 6.0 0.19 11.5 0.0 5.0 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA22249.1 - 1.1e-06 28.6 1.8 0.022 14.9 0.0 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Pkinase_Tyr PF07714.12 ESA22250.1 - 3.3e-49 167.2 0.0 1.5e-48 165.1 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22250.1 - 1.7e-46 158.5 1.2 3.2e-46 157.5 0.8 1.4 1 0 0 1 1 1 1 Protein kinase domain DAGK_cat PF00781.19 ESA22251.1 - 1.9e-24 85.5 0.1 3.6e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Tim54 PF11711.3 ESA22251.1 - 0.11 11.0 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Piwi PF02171.12 ESA22252.1 - 6.4e-101 337.2 0.0 8.6e-101 336.8 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA22252.1 - 9e-24 83.3 0.1 4.6e-23 81.0 0.0 2.1 2 0 0 2 2 2 1 PAZ domain DUF1785 PF08699.5 ESA22252.1 - 6.1e-16 57.5 0.0 1.8e-15 56.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) DASH_Duo1 PF08651.5 ESA22253.1 - 3.5e-13 48.9 1.5 9.1e-13 47.5 1.1 1.7 1 0 0 1 1 1 1 DASH complex subunit Duo1 TarH PF02203.10 ESA22253.1 - 0.043 13.6 0.5 0.071 12.9 0.3 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF755 PF05501.6 ESA22253.1 - 0.93 9.5 4.8 5.3 7.1 3.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF755) TPR_11 PF13414.1 ESA22254.1 - 1.1e-36 124.2 12.9 2e-14 52.9 0.2 5.4 3 2 1 5 5 5 4 TPR repeat TPR_1 PF00515.23 ESA22254.1 - 1.3e-25 87.8 14.7 3.2e-06 26.5 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22254.1 - 1.7e-25 86.7 15.9 8.4e-05 22.2 0.1 8.6 8 1 1 9 9 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22254.1 - 5.7e-25 87.3 0.2 2.8e-07 31.0 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat DnaJ PF00226.26 ESA22254.1 - 1.2e-23 82.5 1.1 1.2e-23 82.5 0.8 3.3 4 0 0 4 4 4 1 DnaJ domain TPR_19 PF14559.1 ESA22254.1 - 1.6e-18 66.8 6.5 1.4e-06 28.5 1.3 6.1 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_9 PF13371.1 ESA22254.1 - 2.4e-17 62.5 0.3 0.00045 20.0 0.0 4.3 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA22254.1 - 6.1e-17 60.6 0.7 0.045 14.3 0.1 7.6 4 2 5 9 9 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA22254.1 - 6.2e-13 47.5 14.4 0.00053 19.5 0.0 7.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22254.1 - 7.2e-13 47.6 10.7 0.0039 17.2 0.1 7.5 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22254.1 - 4.3e-08 32.9 7.2 0.017 15.0 0.1 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22254.1 - 2.1e-07 30.9 14.9 0.034 14.6 0.3 7.1 9 1 1 10 10 6 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA22254.1 - 2.8e-06 27.1 4.3 0.11 12.3 0.0 4.5 4 1 1 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 ESA22254.1 - 8.4e-05 22.6 7.9 0.78 9.9 0.0 5.4 3 1 2 6 6 5 1 Tetratricopeptide repeat Coatomer_E PF04733.9 ESA22254.1 - 0.0001 21.5 5.6 0.00025 20.3 0.5 3.4 2 1 0 3 3 3 1 Coatomer epsilon subunit TPR_15 PF13429.1 ESA22254.1 - 0.00038 19.6 9.1 0.018 14.1 0.9 3.9 2 2 1 3 3 3 2 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA22254.1 - 0.001 18.2 0.1 0.58 9.4 0.0 3.6 3 0 0 3 3 3 1 SHNi-TPR TPR_7 PF13176.1 ESA22254.1 - 0.0063 16.2 1.9 8.9 6.3 0.1 4.8 3 1 0 3 3 3 0 Tetratricopeptide repeat NAAA-beta PF15508.1 ESA22254.1 - 0.033 14.5 1.5 0.14 12.4 0.1 2.6 3 0 0 3 3 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Phage_sheath_1 PF04984.9 ESA22254.1 - 0.069 11.5 1.0 4.5 5.5 0.1 3.0 1 1 1 3 3 3 0 Phage tail sheath protein TPR_21 PF09976.4 ESA22254.1 - 0.24 11.3 14.3 0.17 11.7 0.9 4.8 2 2 3 5 5 5 0 Tetratricopeptide repeat DUF4175 PF13779.1 ESA22254.1 - 0.77 7.3 7.6 0.46 8.1 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4175) PI3Ka PF00613.15 ESA22254.1 - 3.3 6.8 8.4 0.15 11.1 0.1 2.6 3 0 0 3 3 3 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4398 PF14346.1 ESA22254.1 - 3.6 7.6 21.3 1.3 9.1 0.5 5.2 4 1 2 6 6 6 0 Domain of unknown function (DUF4398) MIT PF04212.13 ESA22254.1 - 4.6 7.2 11.2 20 5.1 0.0 5.2 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain YfdX PF10938.3 ESA22254.1 - 7.4 6.2 13.7 1.6 8.4 3.7 3.8 2 2 1 3 3 3 0 YfdX protein PepSY_TM_1 PF13172.1 ESA22256.1 - 0.22 11.3 0.1 0.22 11.3 0.1 2.5 2 0 0 2 2 2 0 PepSY-associated TM helix EMP70 PF02990.11 ESA22257.1 - 3.4e-212 705.5 14.5 4.6e-212 705.1 10.0 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 rve PF00665.21 ESA22257.1 - 0.1 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Integrase core domain CPSase_sm_chain PF00988.17 ESA22258.1 - 6.5e-46 155.0 0.0 1.1e-45 154.3 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 ESA22258.1 - 1.4e-38 132.2 0.0 1.9e-38 131.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 ESA22258.1 - 0.09 12.1 0.1 2.2 7.6 0.1 2.5 1 1 0 1 1 1 0 Peptidase C26 WBP-1 PF11669.3 ESA22259.1 - 0.15 12.1 0.4 0.17 11.9 0.3 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 HSP70 PF00012.15 ESA22260.1 - 2.3e-80 270.2 16.7 2.3e-48 164.5 0.1 3.5 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA22260.1 - 2.9e-06 26.1 0.1 1.3e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein DUF1639 PF07797.9 ESA22260.1 - 0.017 14.5 0.1 0.038 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) tRNA-synt_2b PF00587.20 ESA22260.1 - 0.027 14.0 1.0 0.084 12.4 0.7 1.8 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) SF3b1 PF08920.5 ESA22260.1 - 0.074 13.0 0.1 0.074 13.0 0.1 3.1 3 0 0 3 3 3 0 Splicing factor 3B subunit 1 MCM PF00493.18 ESA22266.1 - 4.2e-14 52.1 0.7 6.7e-14 51.4 0.0 1.6 2 0 0 2 2 2 1 MCM2/3/5 family AAT PF03417.11 ESA22266.1 - 0.0028 17.1 0.1 0.0035 16.8 0.1 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase SurA_N PF09312.6 ESA22266.1 - 0.014 15.1 1.2 0.025 14.4 0.7 1.6 1 1 1 2 2 2 0 SurA N-terminal domain Methyltransf_33 PF10017.4 ESA22266.1 - 0.061 13.2 1.1 0.14 12.0 0.5 1.8 1 1 1 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent SPC25 PF06703.6 ESA22267.1 - 1.7e-38 131.7 2.5 2e-38 131.4 1.7 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) TAN PF11640.3 ESA22267.1 - 0.006 16.3 0.4 0.01 15.6 0.3 1.3 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair CIA30 PF08547.7 ESA22267.1 - 0.051 13.4 0.5 0.088 12.6 0.3 1.4 1 0 0 1 1 1 0 Complex I intermediate-associated protein 30 (CIA30) Holin_BlyA PF05102.7 ESA22267.1 - 0.074 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 holin, BlyA family Pkinase PF00069.20 ESA22268.1 - 7e-72 241.6 0.1 1.9e-71 240.2 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22268.1 - 1.3e-42 145.7 0.0 2.9e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.13 ESA22268.1 - 4.8e-34 116.1 5.6 2.9e-19 68.7 0.2 3.3 3 0 0 3 3 3 2 POLO box duplicated region Kinase-like PF14531.1 ESA22268.1 - 6.1e-08 31.9 0.0 7e-07 28.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DUF4524 PF15025.1 ESA22268.1 - 0.00014 21.3 0.1 0.065 12.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4524) DUF4520 PF15016.1 ESA22268.1 - 0.061 12.8 0.0 0.32 10.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) Alb1 PF09135.6 ESA22269.1 - 0.49 11.0 7.7 0.66 10.6 5.3 1.2 1 0 0 1 1 1 0 Alb1 Cucumo_2B PF03263.8 ESA22269.1 - 3.9 7.8 5.3 7.4 6.9 3.7 1.5 1 1 0 1 1 1 0 Cucumovirus protein 2B HhH-GPD PF00730.20 ESA22270.1 - 1e-06 28.9 0.0 2.1e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Exo_endo_phos PF03372.18 ESA22271.1 - 6.2e-19 68.8 0.0 7.5e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Filament PF00038.16 ESA22273.1 - 0.026 13.9 0.7 0.032 13.7 0.5 1.1 1 0 0 1 1 1 0 Intermediate filament protein TMF_TATA_bd PF12325.3 ESA22273.1 - 0.028 14.1 1.4 0.043 13.5 1.0 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF4201 PF13870.1 ESA22273.1 - 0.03 13.7 1.4 0.04 13.3 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DivIC PF04977.10 ESA22273.1 - 0.047 13.1 3.2 0.21 11.1 0.4 2.3 1 1 1 2 2 2 0 Septum formation initiator PEARLI-4 PF05278.7 ESA22273.1 - 0.087 12.1 2.1 0.11 11.9 1.5 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Seryl_tRNA_N PF02403.17 ESA22273.1 - 0.14 12.2 4.2 0.2 11.6 2.9 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF972 PF06156.8 ESA22273.1 - 0.14 12.4 2.8 0.78 10.1 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Tropomyosin_1 PF12718.2 ESA22273.1 - 0.17 11.7 6.4 0.25 11.1 4.4 1.1 1 0 0 1 1 1 0 Tropomyosin like IncA PF04156.9 ESA22273.1 - 0.17 11.4 1.4 0.21 11.1 1.0 1.1 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ESA22273.1 - 0.47 10.4 5.0 0.54 10.2 0.5 2.6 1 1 2 3 3 3 0 bZIP transcription factor ADIP PF11559.3 ESA22273.1 - 0.53 10.1 3.6 0.82 9.5 2.5 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SH3_1 PF00018.23 ESA22274.1 - 2.5e-31 106.8 0.3 9.6e-17 60.1 0.0 2.8 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.1 ESA22274.1 - 6.1e-20 70.5 0.2 1.3e-10 40.7 0.1 3.1 3 0 0 3 3 3 2 Variant SH3 domain SH3_2 PF07653.12 ESA22274.1 - 5.6e-15 54.5 0.0 8.3e-10 38.0 0.0 2.8 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.19 ESA22274.1 - 2.6e-10 40.0 0.0 5.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 PX domain PB1 PF00564.19 ESA22274.1 - 0.00073 19.1 0.2 0.0015 18.1 0.1 1.5 1 0 0 1 1 1 1 PB1 domain PTPLA PF04387.9 ESA22275.1 - 7.5e-57 191.3 9.2 1.1e-56 190.7 6.4 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Cpn60_TCP1 PF00118.19 ESA22276.1 - 1e-137 459.7 11.6 1.2e-137 459.5 8.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transposase_23 PF03017.9 ESA22276.1 - 0.08 12.4 0.1 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 TNP1/EN/SPM transposase DUF3879 PF12995.2 ESA22277.1 - 0.019 14.5 1.5 0.071 12.6 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3879) IL1 PF00340.14 ESA22277.1 - 0.077 12.4 1.3 0.1 12.0 0.3 1.6 1 1 1 2 2 2 0 Interleukin-1 / 18 Ribosomal_S9 PF00380.14 ESA22278.1 - 1.5e-36 125.3 0.1 1.6e-36 125.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Y_phosphatase2 PF03162.8 ESA22279.1 - 4.8e-43 146.3 0.0 5.8e-43 146.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 ESA22279.1 - 0.011 15.0 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PAS_8 PF13188.1 ESA22279.1 - 0.077 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 PAS domain Y_phosphatase3 PF13350.1 ESA22279.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.6 2 0 0 2 2 2 0 Tyrosine phosphatase family Amidase_2 PF01510.20 ESA22281.1 - 1.9e-16 60.3 0.0 3e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase MFS_1 PF07690.11 ESA22282.1 - 1.7e-19 69.7 10.9 2e-19 69.5 7.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA22282.1 - 0.011 14.2 8.9 0.025 13.1 6.1 1.5 1 1 0 1 1 1 0 Sugar (and other) transporter Sedlin_N PF04628.8 ESA22283.1 - 1.3e-34 118.9 0.1 1.5e-34 118.7 0.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 ESA22283.1 - 0.0059 16.3 0.5 0.0087 15.7 0.1 1.4 2 0 0 2 2 2 1 Sybindin-like family Methyltransf_23 PF13489.1 ESA22284.1 - 3.7e-11 43.0 0.0 5.7e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA22284.1 - 9e-10 38.9 0.0 2e-09 37.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA22284.1 - 3.6e-08 33.6 0.0 8.7e-08 32.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA22284.1 - 1.6e-07 31.0 0.0 1.5e-06 27.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA22284.1 - 6.9e-05 22.0 0.0 0.00021 20.4 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 ESA22284.1 - 8.4e-05 22.9 0.0 0.00027 21.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA22284.1 - 0.00027 21.4 0.0 0.0013 19.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA22284.1 - 0.0024 16.9 0.0 0.0058 15.6 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase MetW PF07021.7 ESA22284.1 - 0.004 16.5 0.0 0.0088 15.4 0.0 1.5 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.14 ESA22284.1 - 0.005 16.8 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_26 PF13659.1 ESA22284.1 - 0.044 13.8 0.0 0.093 12.7 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF3206 PF11472.3 ESA22285.1 - 0.045 13.5 0.2 0.076 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3206) DEAD PF00270.24 ESA22286.1 - 4e-18 65.4 0.0 1.7e-16 60.1 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA22286.1 - 1.5e-07 31.1 0.0 2.9e-06 27.0 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA22286.1 - 1.3e-06 28.4 0.7 7.5e-05 22.6 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RQC PF09382.5 ESA22286.1 - 1.4e-05 24.7 0.1 5.2e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 RQC domain TPR_11 PF13414.1 ESA22287.1 - 1.7e-14 53.1 5.6 2.4e-12 46.3 0.4 3.6 2 1 0 3 3 3 1 TPR repeat SET PF00856.23 ESA22287.1 - 1.4e-09 38.4 0.3 5e-08 33.4 0.0 3.3 3 1 0 3 3 3 1 SET domain TPR_2 PF07719.12 ESA22287.1 - 2.8e-09 36.1 5.7 0.29 11.1 0.0 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.1 ESA22287.1 - 2.7e-08 34.0 0.4 0.065 13.5 0.1 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22287.1 - 1.6e-07 31.7 0.6 0.014 16.0 0.2 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA22287.1 - 1.8e-06 28.0 2.0 0.00019 21.4 0.7 3.4 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 ESA22287.1 - 4.7e-06 25.9 4.2 0.82 9.3 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22287.1 - 2e-05 24.4 0.4 0.25 11.6 0.2 4.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA22287.1 - 0.00051 20.4 0.0 4.5 8.1 0.0 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22287.1 - 0.0021 17.9 3.1 2.4 8.1 0.0 3.8 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22287.1 - 0.079 13.4 3.6 3 8.4 0.0 3.9 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA22287.1 - 1.8 8.4 12.0 0.97 9.3 0.1 4.6 4 1 1 5 5 4 0 Tetratricopeptide repeat Dimer_Tnp_hAT PF05699.9 ESA22289.1 - 5.2e-21 74.0 0.1 1e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA22289.1 - 0.026 14.5 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) RHS PF03527.9 ESA22290.1 - 0.075 12.8 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 RHS protein Rad9 PF04139.8 ESA22291.1 - 0.0025 17.0 0.0 0.0029 16.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 zf-BED PF02892.10 ESA22291.1 - 0.02 14.6 0.2 0.033 13.9 0.2 1.4 1 0 0 1 1 1 0 BED zinc finger Pkinase_Tyr PF07714.12 ESA22292.1 - 5e-22 78.2 0.1 1.4e-21 76.7 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22292.1 - 1.2e-16 60.6 4.2 5.6e-16 58.4 2.9 2.2 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA22292.1 - 0.066 12.8 0.7 3.7 7.1 0.0 3.5 5 0 0 5 5 5 0 BCS1 N terminal HypA PF01155.14 ESA22292.1 - 0.97 9.1 12.4 9 6.0 0.0 4.2 4 0 0 4 4 4 0 Hydrogenase expression/synthesis hypA family DUF2789 PF10982.3 ESA22292.1 - 1.3 9.0 6.4 1.3e+02 2.6 0.0 4.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2789) zinc_ribbon_2 PF13240.1 ESA22294.1 - 0.39 10.2 12.5 0.74 9.3 0.7 2.7 2 0 0 2 2 2 0 zinc-ribbon domain AntA PF08346.7 ESA22294.1 - 1.9 8.7 7.6 16 5.7 0.1 3.6 3 0 0 3 3 3 0 AntA/AntB antirepressor H-kinase_dim PF02895.9 ESA22295.1 - 0.0097 16.2 0.8 0.013 15.8 0.6 1.2 1 0 0 1 1 1 1 Signal transducing histidine kinase, homodimeric domain Lebercilin PF15619.1 ESA22295.1 - 0.058 12.8 4.8 0.06 12.7 3.3 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF2422 PF10337.4 ESA22295.1 - 0.074 11.8 0.2 0.077 11.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) Seryl_tRNA_N PF02403.17 ESA22295.1 - 0.086 12.8 5.6 0.095 12.7 3.9 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3420 PF11900.3 ESA22295.1 - 0.24 11.5 1.4 0.36 10.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) V-SNARE PF05008.10 ESA22295.1 - 0.47 10.6 3.7 0.57 10.3 1.4 1.8 1 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF3763 PF12592.3 ESA22295.1 - 1.3 8.7 4.1 5.1 6.7 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3763) Sel1 PF08238.7 ESA22296.1 - 2.7e-08 34.1 0.0 9.6e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 Sel1 repeat DUF2919 PF11143.3 ESA22297.1 - 0.11 12.3 0.1 0.11 12.3 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) DUF750 PF04721.12 ESA22300.1 - 1.1 9.2 6.8 17 5.4 4.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF750) Pkinase PF00069.20 ESA22301.1 - 2.4e-40 138.3 0.3 3.9e-40 137.6 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22301.1 - 2.4e-38 131.6 0.0 3.5e-38 131.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA22301.1 - 0.00039 19.8 3.1 0.0017 17.7 1.3 2.4 1 1 1 2 2 2 1 RIO1 family APH PF01636.18 ESA22301.1 - 0.003 17.3 0.0 0.0049 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 ESA22301.1 - 0.025 13.9 0.2 0.065 12.5 0.1 1.7 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA22301.1 - 0.037 13.0 0.0 0.075 12.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HAMP PF00672.20 ESA22301.1 - 0.07 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 HAMP domain DUF2551 PF10826.3 ESA22301.1 - 0.21 11.5 1.1 2.3 8.1 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2551) DUF964 PF06133.6 ESA22301.1 - 0.22 11.5 5.4 1.6 8.7 1.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF964) Kinesin PF00225.18 ESA22302.1 - 8.4e-30 103.6 0.0 9.7e-30 103.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA22302.1 - 0.026 13.4 0.1 0.034 13.0 0.1 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 ESA22302.1 - 0.099 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin P2 PF07194.6 ESA22302.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 P2 response regulator binding domain AAA_22 PF13401.1 ESA22302.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain F-box-like PF12937.2 ESA22303.1 - 1.9e-05 24.2 1.1 6.5e-05 22.5 0.7 2.0 1 0 0 1 1 1 1 F-box-like XPA_N PF01286.13 ESA22304.1 - 0.037 13.7 1.4 5.2 6.8 0.2 2.7 2 0 0 2 2 2 0 XPA protein N-terminal Glycoamylase PF10091.4 ESA22304.1 - 0.07 12.1 0.2 0.12 11.4 0.1 1.4 1 1 0 1 1 1 0 Putative glucoamylase Toxin_17 PF08086.6 ESA22304.1 - 0.5 10.4 5.0 0.33 11.0 0.6 2.5 2 0 0 2 2 2 0 Ergtoxin family C1_1 PF00130.17 ESA22304.1 - 0.76 9.5 5.7 19 5.1 1.3 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinesin PF00225.18 ESA22305.1 - 4.6e-30 104.4 0.0 5.3e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 ESA22305.1 - 0.045 12.6 0.0 0.065 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 ESA22305.1 - 0.091 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.1 ESA22305.1 - 0.16 11.5 0.6 0.22 11.0 0.4 1.2 1 0 0 1 1 1 0 AAA domain HMG_box PF00505.14 ESA22306.1 - 5.8e-08 32.8 0.8 5.8e-08 32.8 0.6 1.6 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA22306.1 - 0.0017 18.6 1.0 0.0017 18.6 0.7 1.8 2 0 0 2 2 2 1 HMG-box domain Pol_alpha_B_N PF08418.5 ESA22306.1 - 0.024 14.1 6.5 0.03 13.8 4.5 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Pyr_excise PF03013.9 ESA22306.1 - 0.36 10.5 4.0 0.19 11.5 0.5 1.9 2 0 0 2 2 2 0 Pyrimidine dimer DNA glycosylase DUF4512 PF14975.1 ESA22306.1 - 2.5 8.9 5.7 4.1 8.2 3.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) FAM196 PF15265.1 ESA22308.1 - 0.16 11.2 3.3 0.16 11.1 2.3 1.0 1 0 0 1 1 1 0 FAM196 family JmjC PF02373.17 ESA22310.1 - 3.8e-40 136.6 0.1 9.5e-40 135.3 0.1 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.16 ESA22310.1 - 2.3e-17 62.6 0.2 2.6e-16 59.2 0.1 2.3 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain JmjN PF02375.12 ESA22310.1 - 1.3e-15 56.5 1.3 3.3e-15 55.2 0.9 1.8 1 0 0 1 1 1 1 jmjN domain PHD PF00628.24 ESA22310.1 - 4.7e-13 48.6 31.8 4.7e-10 38.9 11.3 3.8 3 1 1 4 4 4 2 PHD-finger PLDc PF00614.17 ESA22312.1 - 4.3e-10 39.0 0.1 9.6e-10 37.9 0.1 1.6 1 0 0 1 1 1 1 Phospholipase D Active site motif PX PF00787.19 ESA22312.1 - 2.1e-07 30.7 2.5 2.7e-07 30.3 0.6 2.0 2 0 0 2 2 2 1 PX domain PLDc_2 PF13091.1 ESA22312.1 - 0.0011 18.6 0.0 0.0025 17.5 0.0 1.6 1 0 0 1 1 1 1 PLD-like domain DYW_deaminase PF14432.1 ESA22312.1 - 0.039 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases UvrD_C PF13361.1 ESA22313.1 - 3.5e-14 53.0 0.0 1.6e-10 40.9 0.0 2.8 1 1 1 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 ESA22313.1 - 2.2e-08 34.1 0.1 8.4e-07 29.0 0.0 2.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 ESA22313.1 - 3.7e-05 23.1 6.6 3.7e-05 23.1 4.6 1.7 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_12 PF13087.1 ESA22313.1 - 0.00028 20.3 0.2 0.04 13.2 0.0 3.0 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.13 ESA22313.1 - 0.012 15.1 0.0 3.3 7.1 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase RE_TaqI PF09573.5 ESA22313.1 - 0.069 12.2 6.7 0.25 10.4 0.2 3.1 2 1 1 3 3 3 0 TaqI restriction endonuclease Transposase_21 PF02992.9 ESA22315.1 - 1.7e-07 30.5 0.1 2.6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Transposase family tnp2 PP2C PF00481.16 ESA22317.1 - 1e-39 136.5 0.0 2.1e-39 135.4 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.1 ESA22317.1 - 0.018 14.4 0.0 0.046 13.1 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C UBA_e1_C PF09358.5 ESA22318.1 - 0.44 10.7 3.8 0.19 11.9 0.3 2.1 2 1 0 2 2 2 0 Ubiquitin-activating enzyme e1 C-terminal domain zf-U1 PF06220.7 ESA22319.1 - 0.0039 16.7 2.5 0.0039 16.7 1.7 1.7 2 0 0 2 2 2 1 U1 zinc finger AKAP95 PF04988.7 ESA22319.1 - 0.01 15.6 1.3 0.013 15.2 0.9 1.2 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) CarbpepA_inh PF02977.10 ESA22321.1 - 0.19 11.2 0.7 3 7.5 0.2 2.3 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor XPG_I PF00867.13 ESA22322.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.7 1 0 0 1 1 1 0 XPG I-region RAMPs PF03787.10 ESA22322.1 - 0.063 13.1 0.6 0.31 10.8 0.4 1.8 1 1 0 1 1 1 0 RAMP superfamily zf-RING_2 PF13639.1 ESA22324.1 - 1.6e-08 34.2 7.0 1.6e-08 34.2 4.9 1.6 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.2 ESA22324.1 - 1.9e-07 31.0 1.7 4.6e-07 29.8 1.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 ESA22324.1 - 5.8e-07 29.3 5.4 1.4e-06 28.1 3.7 1.7 1 1 0 1 1 1 1 FANCL C-terminal domain zf-Apc11 PF12861.2 ESA22324.1 - 3.4e-05 23.6 1.5 7e-05 22.5 1.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 ESA22324.1 - 0.00015 21.7 6.7 0.00043 20.2 4.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA22324.1 - 0.0003 20.3 8.3 0.0003 20.3 5.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 ESA22324.1 - 0.0011 18.9 6.1 0.002 18.1 4.2 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_4 PF14570.1 ESA22324.1 - 0.014 14.9 5.5 0.024 14.2 3.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 ESA22324.1 - 0.094 12.7 6.5 0.27 11.2 4.5 1.9 1 1 0 1 1 1 0 RING-like domain C1_1 PF00130.17 ESA22324.1 - 0.11 12.2 5.7 0.052 13.2 1.3 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.24 ESA22324.1 - 0.4 10.3 5.0 0.75 9.5 3.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_3 PF13920.1 ESA22324.1 - 2.2 8.0 11.0 21 4.8 7.7 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA22324.1 - 6.3 6.7 8.3 34 4.4 5.8 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Pkinase PF00069.20 ESA22326.1 - 1.6e-33 116.0 0.0 2.3e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22326.1 - 2.1e-27 95.8 0.0 2.7e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA22326.1 - 0.0082 15.9 0.1 0.017 14.8 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA22326.1 - 0.055 12.6 0.1 0.11 11.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Oxidored_q1_N PF00662.15 ESA22326.1 - 0.081 12.4 0.3 0.18 11.3 0.2 1.6 1 0 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Cu-binding_MopE PF11617.3 ESA22326.1 - 0.6 9.9 2.1 0.72 9.6 0.2 2.0 2 0 0 2 2 2 0 Protein metal binding site Sel1 PF08238.7 ESA22327.1 - 3.4e-55 183.2 17.7 2.8e-11 43.6 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_11 PF13414.1 ESA22327.1 - 0.0059 16.2 3.0 0.0059 16.2 2.1 4.2 2 2 2 4 4 4 2 TPR repeat Peptidase_M57 PF12388.3 ESA22329.1 - 0.014 14.7 0.3 0.036 13.3 0.2 1.6 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Cohesin PF00963.13 ESA22329.1 - 0.072 12.9 0.8 10 5.9 0.0 2.8 2 0 0 2 2 2 0 Cohesin domain TarH PF02203.10 ESA22329.1 - 1.4 8.7 8.2 2.4 7.9 5.7 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue IncA PF04156.9 ESA22329.1 - 4.9 6.7 19.8 13 5.3 13.7 1.7 1 0 0 1 1 1 0 IncA protein RBD-FIP PF09457.5 ESA22330.1 - 0.27 11.0 4.3 0.8 9.5 1.1 3.0 2 0 0 2 2 2 0 FIP domain Sel1 PF08238.7 ESA22332.1 - 2.6e-91 298.0 55.5 9.8e-11 41.9 0.1 13.3 13 0 0 13 13 13 11 Sel1 repeat Pkinase PF00069.20 ESA22332.1 - 3.4e-49 167.3 0.9 1.1e-48 165.7 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22332.1 - 3e-48 164.1 0.0 5.1e-48 163.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_6 PF13174.1 ESA22332.1 - 0.00018 21.7 22.2 7.6 7.2 0.0 9.4 10 0 0 10 10 10 1 Tetratricopeptide repeat Kdo PF06293.9 ESA22332.1 - 0.012 14.6 0.4 0.024 13.7 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA22332.1 - 0.014 15.1 0.0 0.43 10.2 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA22332.1 - 0.034 13.1 0.0 0.059 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SH3_1 PF00018.23 ESA22335.1 - 2.7e-12 45.8 0.6 1e-11 43.9 0.2 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 ESA22335.1 - 5.5e-12 45.0 0.0 1.3e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.12 ESA22335.1 - 9.7e-12 44.5 0.0 2.5e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.24 ESA22335.1 - 3.8e-10 39.9 0.8 1.1e-09 38.4 0.1 2.2 2 0 0 2 2 2 1 PH domain SAM_1 PF00536.25 ESA22335.1 - 1.1e-07 31.9 0.0 2.1e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.12 ESA22335.1 - 6.8e-06 25.4 0.1 1.5e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_PNT PF02198.11 ESA22335.1 - 0.011 15.4 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Sterile PF03015.14 ESA22336.1 - 4.3 7.6 8.9 1.3 9.3 0.2 3.2 3 0 0 3 3 3 0 Male sterility protein Alpha_kinase PF02816.13 ESA22337.1 - 0.00017 21.2 0.0 0.00021 21.0 0.0 1.1 1 0 0 1 1 1 1 Alpha-kinase family Pox_A3L PF05288.6 ESA22337.1 - 0.068 12.9 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 Poxvirus A3L Protein Peptidase_M8 PF01457.11 ESA22338.1 - 0.16 10.3 0.0 0.26 9.5 0.0 1.2 1 0 0 1 1 1 0 Leishmanolysin ICMT PF04140.9 ESA22339.1 - 2.3e-13 50.1 2.9 3.1e-13 49.7 2.0 1.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 ESA22339.1 - 2.2e-07 30.9 2.1 2.9e-07 30.5 1.4 1.2 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1084 PF06454.6 ESA22339.1 - 0.16 10.9 3.9 0.21 10.6 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1084) Pyridoxal_deC PF00282.14 ESA22340.1 - 6.2e-21 74.2 0.1 1.7e-14 53.0 0.0 3.4 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.16 ESA22340.1 - 0.0033 16.6 0.0 0.0067 15.6 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase LRR_4 PF12799.2 ESA22341.1 - 0.073 12.7 12.7 2.3 7.9 0.1 4.7 4 1 2 6 6 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA22345.1 - 0.0011 18.7 0.0 0.0056 16.4 0.0 2.0 2 1 0 2 2 2 1 Leucine rich repeat LRR_5 PF13306.1 ESA22345.1 - 0.012 15.2 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 0 Leucine rich repeats (6 copies) USP7_C2 PF14533.1 ESA22349.1 - 0.022 14.1 0.1 0.03 13.7 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal Ribosomal_S27e PF01667.12 ESA22351.1 - 0.0002 20.8 0.6 0.00038 19.9 0.4 1.6 1 1 0 1 1 1 1 Ribosomal protein S27 zf-ribbon_3 PF13248.1 ESA22351.1 - 0.012 14.7 2.6 2.1 7.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain tRNA-synt_1 PF00133.17 ESA22353.1 - 0.13 10.2 0.0 0.16 9.9 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Cys_Met_Meta_PP PF01053.15 ESA22354.1 - 2.9e-19 68.6 0.0 3.3e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme NAD_kinase PF01513.16 ESA22355.1 - 7e-66 221.9 0.0 1e-65 221.3 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase MMR_HSR1 PF01926.18 ESA22357.1 - 5e-08 32.9 0.3 2.5e-07 30.6 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA22357.1 - 5.2e-05 22.4 0.0 0.00017 20.8 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 ESA22357.1 - 0.00014 21.3 0.5 0.023 14.1 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 ESA22357.1 - 0.00035 20.6 0.0 0.0017 18.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 ESA22357.1 - 0.00076 18.9 0.0 0.0019 17.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.24 ESA22357.1 - 0.0062 16.7 0.5 0.26 11.4 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 ESA22357.1 - 0.036 13.5 0.0 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.1 ESA22357.1 - 0.044 13.9 0.0 0.27 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 ESA22357.1 - 0.045 12.6 0.0 0.098 11.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein MobB PF03205.9 ESA22357.1 - 0.046 13.4 0.2 0.4 10.3 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 ESA22357.1 - 0.05 14.4 2.7 0.19 12.5 0.0 3.3 3 0 0 3 3 2 0 AAA domain NACHT PF05729.7 ESA22357.1 - 0.056 13.0 0.0 0.27 10.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 ESA22357.1 - 0.084 13.1 0.0 0.084 13.1 0.0 3.3 3 1 0 3 3 2 0 AAA domain ABC_tran PF00005.22 ESA22357.1 - 0.12 12.6 0.0 0.12 12.6 0.0 3.4 3 1 0 3 3 2 0 ABC transporter Dynamin_N PF00350.18 ESA22357.1 - 2.6 7.8 7.6 7 6.4 0.0 4.0 3 1 0 3 3 2 0 Dynamin family Abhydrolase_3 PF07859.8 ESA22358.1 - 1.7e-38 132.3 0.1 4.7e-32 111.2 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold DUF2424 PF10340.4 ESA22358.1 - 4.9e-12 45.1 0.1 1e-11 44.1 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 ESA22358.1 - 5.2e-07 29.5 0.0 7.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 ESA22358.1 - 0.022 14.1 0.0 0.095 12.1 0.0 2.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase FYRC PF05965.9 ESA22359.1 - 0.0019 17.9 0.0 0.028 14.2 0.0 2.5 1 1 0 1 1 1 1 F/Y rich C-terminus SecA_DEAD PF07517.9 ESA22359.1 - 0.026 13.8 0.2 0.061 12.5 0.1 1.7 1 0 0 1 1 1 0 SecA DEAD-like domain DUF4001 PF13165.1 ESA22360.1 - 0.11 12.2 0.3 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4001) DUF2783 PF10932.3 ESA22360.1 - 0.15 11.5 0.5 0.18 11.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) Cpn60_TCP1 PF00118.19 ESA22361.1 - 1.4e-163 545.0 0.7 1.6e-163 544.8 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family RRM_1 PF00076.17 ESA22367.1 - 7.2e-19 67.1 0.0 1.2e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22367.1 - 8.9e-14 51.2 0.0 1.7e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA22367.1 - 3.4e-10 39.6 0.0 5.5e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 ESA22367.1 - 1.4e-08 35.0 1.3 1.4e-08 35.0 0.9 3.5 3 1 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 RRM_3 PF08777.6 ESA22367.1 - 0.0019 18.0 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Btz PF09405.5 ESA22367.1 - 0.0024 17.9 1.9 0.0024 17.9 1.3 1.7 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding TC1 PF15063.1 ESA22367.1 - 0.078 12.5 0.1 0.24 10.9 0.0 1.8 1 1 0 1 1 1 0 Thyroid cancer protein 1 Bud13 PF09736.4 ESA22368.1 - 7e-34 117.1 13.2 7e-34 117.1 9.1 3.1 2 2 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex A_deaminase_N PF08451.6 ESA22368.1 - 0.38 10.7 3.6 0.4 10.7 1.4 1.9 2 0 0 2 2 2 0 Adenosine/AMP deaminase N-terminal MBF1 PF08523.5 ESA22369.1 - 2.9e-22 78.4 3.0 2.9e-22 78.4 2.1 1.6 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 ESA22369.1 - 1.3e-10 40.9 0.5 2.3e-10 40.1 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.2 ESA22369.1 - 0.00014 21.8 0.5 0.00023 21.1 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 ESA22369.1 - 0.00018 21.6 0.0 0.00034 20.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain CoA_transf_3 PF02515.12 ESA22370.1 - 4.7e-58 195.5 0.0 5.8e-58 195.2 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III IL7 PF01415.11 ESA22371.1 - 0.04 13.5 0.2 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Interleukin 7/9 family Sec7 PF01369.15 ESA22372.1 - 2.6e-45 154.4 1.6 4.9e-45 153.5 1.1 1.4 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 ESA22372.1 - 9e-16 58.1 0.3 1.9e-14 53.8 0.0 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 ESA22372.1 - 1.2e-10 41.4 0.1 1.2e-10 41.4 0.1 3.3 5 0 0 5 5 5 1 PH domain DUF2004 PF09406.5 ESA22372.1 - 0.063 13.3 0.4 0.22 11.5 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) Mucin PF01456.12 ESA22372.1 - 0.34 10.6 15.6 0.8 9.4 10.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Sel1 PF08238.7 ESA22374.1 - 2.8e-11 43.6 3.7 1.2e-09 38.4 0.1 2.7 3 0 0 3 3 3 2 Sel1 repeat TPR_2 PF07719.12 ESA22374.1 - 1.9 8.6 4.3 1.7 8.7 0.1 3.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA22374.1 - 3.2 7.5 9.3 1.9 8.2 0.1 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Cation_ATPase_N PF00690.21 ESA22375.1 - 0.085 12.3 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus DnaJ PF00226.26 ESA22376.1 - 2.2e-21 75.3 1.4 5.4e-21 74.1 0.2 2.1 2 0 0 2 2 2 1 DnaJ domain DnaJ-X PF14308.1 ESA22376.1 - 5.9e-16 58.3 6.0 9.9e-08 31.4 0.0 2.8 2 2 1 3 3 3 2 X-domain of DnaJ-containing DMAP_binding PF06464.6 ESA22376.1 - 0.001 19.6 2.8 0.001 19.6 2.0 2.3 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.7 ESA22376.1 - 0.0014 18.4 0.2 0.0036 17.0 0.2 1.7 1 0 0 1 1 1 1 Gas vesicle protein G SHOCT PF09851.4 ESA22376.1 - 0.0017 17.7 1.1 0.0036 16.7 0.8 1.6 1 0 0 1 1 1 1 Short C-terminal domain HSP70 PF00012.15 ESA22377.1 - 2.1e-17 62.2 0.3 5.7e-15 54.2 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 ESA22377.1 - 0.019 13.6 0.0 0.019 13.5 0.0 1.0 1 0 0 1 1 1 0 MreB/Mbl protein M-factor PF03855.8 ESA22378.1 - 0.051 13.5 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 M-factor DUF1497 PF07384.6 ESA22378.1 - 0.31 11.2 2.9 14 5.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1497) Pkinase_Tyr PF07714.12 ESA22379.1 - 2.1e-24 86.0 0.1 6.7e-24 84.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22379.1 - 3.7e-20 72.1 0.3 7.8e-19 67.8 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain UCH PF00443.24 ESA22380.1 - 6.6e-45 153.3 8.9 2.1e-44 151.6 6.2 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA22380.1 - 4.6e-31 108.3 5.9 1.1e-30 107.1 4.1 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ank_2 PF12796.2 ESA22381.1 - 1.6e-18 66.8 0.5 4.5e-10 39.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 ESA22381.1 - 2.2e-06 27.3 0.7 0.17 12.2 0.0 4.9 4 1 1 5 5 5 2 Ankyrin repeat Ank PF00023.25 ESA22381.1 - 4.3e-06 26.2 3.9 0.007 16.1 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 ESA22381.1 - 8.9e-05 22.8 0.1 0.078 13.5 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 ESA22381.1 - 0.012 15.8 0.2 0.068 13.4 0.1 2.4 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF1977 PF09320.6 ESA22381.1 - 0.12 12.6 1.8 0.34 11.1 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1977) TPR_11 PF13414.1 ESA22382.1 - 1.6e-78 258.3 40.1 5.2e-13 48.4 0.2 9.1 6 2 4 10 10 10 10 TPR repeat TPR_1 PF00515.23 ESA22382.1 - 1.2e-71 233.6 54.6 3.5e-07 29.5 0.1 14.3 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22382.1 - 1.1e-65 212.3 47.0 2.1e-06 27.1 0.1 14.2 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_9 PF13371.1 ESA22382.1 - 4.9e-45 151.2 18.7 4.8e-06 26.3 0.7 8.9 2 1 7 9 9 9 9 Tetratricopeptide repeat TPR_8 PF13181.1 ESA22382.1 - 3e-41 136.1 44.9 0.00012 21.5 0.3 14.2 11 1 3 14 14 14 12 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22382.1 - 1.7e-40 136.7 33.8 7.4e-08 32.2 1.1 9.3 4 2 5 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22382.1 - 1.8e-36 124.0 17.8 2.6e-08 34.3 0.4 7.5 5 2 1 7 7 7 7 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22382.1 - 2.9e-31 105.0 42.8 3.9e-05 23.5 0.1 14.4 15 1 0 15 15 15 9 Tetratricopeptide repeat TPR_14 PF13428.1 ESA22382.1 - 7.2e-21 72.7 22.5 0.015 15.8 0.0 12.2 6 3 7 13 13 13 5 Tetratricopeptide repeat TPR_19 PF14559.1 ESA22382.1 - 2.3e-16 59.8 25.9 0.00021 21.5 0.3 6.6 5 1 2 7 7 7 6 Tetratricopeptide repeat Apc3 PF12895.2 ESA22382.1 - 1.2e-14 54.1 27.8 5.1e-06 26.5 1.3 7.3 2 1 5 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.4 ESA22382.1 - 2.1e-14 52.4 23.0 0.00079 18.6 0.2 9.9 11 0 0 11 11 11 4 SHNi-TPR TPR_7 PF13176.1 ESA22382.1 - 1.9e-12 45.9 17.8 0.46 10.4 0.1 9.2 10 0 0 10 10 8 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA22382.1 - 2.7e-08 33.5 29.1 0.0054 16.5 0.2 8.6 8 2 2 10 10 9 2 Fis1 C-terminal tetratricopeptide repeat DUF3856 PF12968.2 ESA22382.1 - 1.3e-05 25.0 5.7 9.6 6.0 0.0 6.9 6 3 1 7 7 7 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.1 ESA22382.1 - 0.00035 20.8 24.1 1.9 9.1 0.0 10.3 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA22382.1 - 0.0034 17.2 28.8 0.41 10.6 0.2 8.8 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_21 PF09976.4 ESA22382.1 - 0.005 16.8 4.6 5 7.0 0.0 4.6 3 2 1 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.5 ESA22382.1 - 0.018 13.7 5.5 0.35 9.5 0.0 4.1 3 2 2 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) HemY_N PF07219.8 ESA22382.1 - 0.094 12.2 0.0 6.8 6.2 0.0 2.5 2 0 0 2 2 2 0 HemY protein N-terminus NYD-SP12_N PF15015.1 ESA22382.1 - 0.99 7.5 7.0 1.4 7.0 0.2 3.4 3 1 1 5 5 5 0 Spermatogenesis-associated, N-terminal TPR_11 PF13414.1 ESA22383.1 - 4.1e-71 234.5 46.3 4.1e-12 45.5 0.1 8.2 7 1 1 8 8 8 7 TPR repeat TPR_1 PF00515.23 ESA22383.1 - 1.5e-64 211.0 58.7 3.2e-08 32.8 0.1 14.3 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22383.1 - 1.6e-62 202.4 42.0 5.1e-07 29.1 0.0 14.4 15 0 0 15 15 14 13 Tetratricopeptide repeat TPR_8 PF13181.1 ESA22383.1 - 1.7e-40 133.7 59.9 3.5e-06 26.3 0.1 14.4 13 1 1 14 14 14 12 Tetratricopeptide repeat TPR_9 PF13371.1 ESA22383.1 - 2.3e-39 133.0 0.4 1.3e-05 24.9 0.0 8.3 6 1 2 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22383.1 - 3.5e-38 129.4 8.0 0.0003 21.3 0.2 8.0 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22383.1 - 3.3e-35 119.8 37.4 7.1e-08 32.2 0.1 9.7 4 3 7 11 11 11 10 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22383.1 - 1.1e-24 84.5 35.2 0.0039 17.2 0.0 12.7 13 0 0 13 13 13 7 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA22383.1 - 6.3e-19 66.9 15.8 0.0025 17.0 0.6 11.3 11 0 0 11 11 11 3 SHNi-TPR TPR_14 PF13428.1 ESA22383.1 - 2.1e-17 62.0 7.5 6.1 7.7 0.0 12.7 5 4 10 15 15 14 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA22383.1 - 1.3e-16 60.6 28.2 0.017 15.4 0.0 8.1 4 1 6 10 10 10 8 Tetratricopeptide repeat Apc3 PF12895.2 ESA22383.1 - 1.4e-14 53.9 41.3 0.00014 21.9 3.0 7.3 4 3 4 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 ESA22383.1 - 1.3e-09 37.1 13.4 0.18 11.6 0.0 9.3 11 0 0 11 11 9 3 Tetratricopeptide repeat TPR_15 PF13429.1 ESA22383.1 - 6.6e-08 31.9 12.0 0.02 13.9 0.4 6.4 3 2 1 6 6 6 3 Tetratricopeptide repeat TPR_21 PF09976.4 ESA22383.1 - 1.3e-07 31.6 5.4 0.02 14.8 0.0 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22383.1 - 4.1e-06 26.8 25.7 0.17 12.4 0.0 10.6 13 0 0 13 13 10 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA22383.1 - 5.5e-06 26.1 8.4 9.2 6.3 0.3 8.2 10 0 0 10 10 9 0 Tetratricopeptide repeat NARP1 PF12569.3 ESA22383.1 - 6.7e-06 25.1 14.5 0.53 8.9 0.0 6.1 2 1 3 6 6 6 2 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.1 ESA22383.1 - 8.7e-06 25.5 32.0 0.07 13.0 0.1 10.3 12 0 0 12 12 11 1 Fis1 C-terminal tetratricopeptide repeat Syntaxin-6_N PF09177.6 ESA22383.1 - 2.1e-05 24.8 2.8 0.78 10.1 0.0 5.5 5 1 1 6 6 6 1 Syntaxin 6, N-terminal ChAPs PF09295.5 ESA22383.1 - 0.022 13.5 2.2 0.94 8.1 0.2 3.1 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Oxidored-like PF09791.4 ESA22383.1 - 0.15 11.5 3.9 2.7 7.4 0.0 4.2 6 0 0 6 6 5 0 Oxidoreductase-like protein, N-terminal GST_C_3 PF14497.1 ESA22383.1 - 0.45 11.0 2.9 20 5.7 0.0 4.5 2 2 1 4 4 4 0 Glutathione S-transferase, C-terminal domain HHH_3 PF12836.2 ESA22384.1 - 0.00017 21.4 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif Ion_trans PF00520.26 ESA22385.1 - 0.0004 19.6 9.5 0.0013 18.0 6.6 1.9 1 1 0 1 1 1 1 Ion transport protein CBM_20 PF00686.14 ESA22385.1 - 0.032 13.8 0.5 4.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Starch binding domain UQ_con PF00179.21 ESA22386.1 - 1.1e-43 148.0 0.0 1.2e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA22386.1 - 0.016 15.0 0.7 0.06 13.2 0.3 1.8 1 1 1 2 2 2 0 RWD domain Pkinase PF00069.20 ESA22387.1 - 7.8e-21 74.3 0.1 9.8e-21 74.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22387.1 - 2.2e-20 72.8 0.0 2.8e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA22388.1 - 1e-23 83.2 11.9 3.6e-08 33.7 0.6 4.0 4 0 0 4 4 4 4 Sel1 repeat PPR PF01535.15 ESA22388.1 - 0.38 10.8 3.0 31 4.8 0.1 3.7 3 1 1 4 4 4 0 PPR repeat AdoMet_MTase PF07757.8 ESA22388.1 - 0.4 10.8 2.8 0.68 10.0 0.3 2.1 2 1 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase FAM178 PF14816.1 ESA22390.1 - 0.046 12.4 0.0 0.049 12.3 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function, FAM178 PDGF PF00341.12 ESA22390.1 - 0.054 13.6 0.3 0.11 12.6 0.2 1.6 1 1 0 1 1 1 0 PDGF/VEGF domain GCC2_GCC3 PF07699.8 ESA22391.1 - 0.32 10.6 4.3 0.42 10.2 0.2 2.5 2 0 0 2 2 2 0 GCC2 and GCC3 Viral_DNA_bi PF02236.12 ESA22394.1 - 0.12 12.5 0.1 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Viral DNA-binding protein, all alpha domain Sel1 PF08238.7 ESA22396.1 - 3.3e-50 167.4 16.6 2.3e-12 47.1 0.2 4.3 4 0 0 4 4 4 4 Sel1 repeat TPR_6 PF13174.1 ESA22396.1 - 2.5e-09 36.9 7.4 0.097 13.1 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat MIT PF04212.13 ESA22396.1 - 1.3e-08 34.5 8.5 0.35 10.7 0.1 4.4 4 0 0 4 4 4 4 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA22396.1 - 1.8e-05 24.3 0.8 13 5.5 0.0 4.2 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation TPR_17 PF13431.1 ESA22396.1 - 9.7e-05 22.2 9.5 5.3 7.4 0.5 5.6 6 2 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22396.1 - 0.00022 20.7 19.2 0.045 13.4 1.6 3.8 1 1 2 3 3 3 3 TPR repeat TPR_12 PF13424.1 ESA22396.1 - 0.001 18.9 11.4 0.16 11.8 0.7 4.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22396.1 - 0.002 17.9 20.5 19 5.4 0.2 7.1 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA22396.1 - 0.0027 17.8 0.2 8.5 6.5 0.0 3.2 1 1 1 3 3 3 1 Tetratricopeptide repeat zinc-ribbons_6 PF07191.7 ESA22396.1 - 0.0053 16.5 0.5 0.01 15.6 0.3 1.4 1 0 0 1 1 1 1 zinc-ribbons TPR_1 PF00515.23 ESA22396.1 - 0.015 14.9 22.5 18 5.1 0.1 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TOM20_plant PF06552.7 ESA22396.1 - 0.076 12.5 3.7 2 7.9 0.1 3.4 1 1 3 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 DUF3674 PF12426.3 ESA22396.1 - 0.23 10.9 8.0 6.3 6.2 0.0 3.7 4 0 0 4 4 4 0 RNA dependent RNA polymerase TPR_19 PF14559.1 ESA22396.1 - 0.31 11.3 3.0 41 4.6 0.0 3.8 4 1 1 5 5 5 0 Tetratricopeptide repeat GPAT_N PF14829.1 ESA22396.1 - 2.5 7.8 9.7 13 5.5 0.1 3.8 4 0 0 4 4 4 0 Glycerol-3-phosphate acyltransferase N-terminal BTB PF00651.26 ESA22397.1 - 8.3e-20 70.8 1.2 1.3e-18 66.9 0.1 2.4 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA22397.1 - 1.3e-06 28.4 0.7 2.4e-06 27.6 0.5 1.4 1 0 0 1 1 1 1 SPRY domain CAGE1 PF15066.1 ESA22397.1 - 0.066 11.6 3.5 0.03 12.7 0.8 1.5 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family Pkinase PF00069.20 ESA22399.1 - 2.1e-35 122.1 0.5 2.3e-35 121.9 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22399.1 - 4.8e-35 120.8 0.2 5.4e-35 120.7 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA22399.1 - 0.0043 16.1 0.0 0.0055 15.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA22399.1 - 0.0057 16.0 0.4 0.011 15.0 0.2 1.5 1 1 0 1 1 1 1 RIO1 family APH PF01636.18 ESA22399.1 - 0.014 15.1 0.2 0.019 14.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_J1 PF03338.10 ESA22399.1 - 0.056 13.1 0.0 0.2 11.3 0.0 2.0 1 1 1 2 2 2 0 Poxvirus J1 protein HSP70 PF00012.15 ESA22400.1 - 1e-08 33.5 0.0 4e-08 31.6 0.0 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA22400.1 - 1.7e-05 23.5 0.0 0.057 12.0 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein VWA_3 PF13768.1 ESA22400.1 - 0.15 11.7 0.0 0.4 10.3 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain TLD PF07534.11 ESA22401.1 - 8.8e-13 48.4 1.9 2.7e-12 46.8 1.2 2.0 2 0 0 2 2 2 1 TLD Pentapeptide_4 PF13599.1 ESA22401.1 - 0.021 14.6 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) FAR1 PF03101.10 ESA22402.1 - 2.1e-06 28.1 0.3 3.9e-06 27.2 0.2 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain DBD_Tnp_Mut PF03108.10 ESA22402.1 - 0.024 14.2 0.0 0.53 9.8 0.0 2.3 2 0 0 2 2 2 0 MuDR family transposase Lipoprot_C PF08794.5 ESA22403.1 - 0.00087 19.1 0.2 12 5.7 0.0 3.2 3 0 0 3 3 3 3 Lipoprotein GNA1870 C terminal like BCS1_N PF08740.6 ESA22403.1 - 0.0018 17.9 0.0 0.48 10.0 0.0 2.6 3 0 0 3 3 3 2 BCS1 N terminal Cas_Csa5 PF09702.5 ESA22403.1 - 0.0046 17.0 1.7 4.5 7.4 0.0 3.0 3 0 0 3 3 3 2 CRISPR-associated protein (Cas_Csa5) DnaI_N PF07319.6 ESA22403.1 - 0.013 15.7 8.3 0.13 12.5 0.5 3.4 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus BCS1_N PF08740.6 ESA22404.1 - 2.5e-05 23.9 0.0 1.4 8.4 0.0 3.4 3 0 0 3 3 3 3 BCS1 N terminal Cas_Csa5 PF09702.5 ESA22404.1 - 0.006 16.6 2.1 6.4 6.9 0.0 4.0 4 0 0 4 4 4 1 CRISPR-associated protein (Cas_Csa5) DUF2192 PF09958.4 ESA22404.1 - 0.0068 15.6 0.1 1.5 8.0 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2192) Prp18 PF02840.10 ESA22404.1 - 0.054 13.3 0.1 5.9 6.6 0.0 3.0 3 0 0 3 3 3 0 Prp18 domain Pro_dh PF01619.13 ESA22404.1 - 0.062 12.2 0.0 2.2 7.1 0.0 3.1 4 0 0 4 4 4 0 Proline dehydrogenase TraI PF07057.6 ESA22404.1 - 0.089 12.7 0.0 65 3.5 0.0 3.8 4 0 0 4 4 4 0 DNA helicase TraI Glyco_hydro_11 PF00457.12 ESA22404.1 - 4.7 6.4 19.0 0.17 11.2 0.9 4.4 3 1 2 5 5 5 0 Glycosyl hydrolases family 11 Pkinase_Tyr PF07714.12 ESA22405.1 - 1.8e-43 148.4 0.1 1.4e-38 132.4 0.0 4.7 3 1 1 4 4 4 2 Protein tyrosine kinase Pkinase PF00069.20 ESA22405.1 - 3.2e-40 137.9 3.3 1.2e-39 136.0 0.0 3.5 4 0 0 4 4 4 1 Protein kinase domain BCS1_N PF08740.6 ESA22405.1 - 5.3e-09 35.9 0.2 1.4 8.4 0.0 7.6 8 0 0 8 8 8 2 BCS1 N terminal DUF4339 PF14237.1 ESA22405.1 - 4.2e-08 32.6 0.0 9.8 5.8 0.0 6.4 6 0 0 6 6 6 3 Domain of unknown function (DUF4339) SF3a60_bindingd PF12108.3 ESA22405.1 - 1.6 8.3 12.2 38 3.9 0.0 6.1 6 0 0 6 6 6 0 Splicing factor SF3a60 binding domain zf-RING_UBOX PF13445.1 ESA22405.1 - 3.5 7.4 9.0 42 3.9 0.0 6.0 8 0 0 8 8 8 0 RING-type zinc-finger NYN PF01936.13 ESA22406.1 - 7.4e-18 65.2 0.0 1.3e-17 64.4 0.0 1.4 1 0 0 1 1 1 1 NYN domain NYN PF01936.13 ESA22407.1 - 3.3e-14 53.3 0.0 2.8e-13 50.3 0.0 2.0 2 0 0 2 2 2 1 NYN domain NYN PF01936.13 ESA22408.1 - 2.6e-16 60.2 0.0 5.5e-16 59.1 0.0 1.5 2 0 0 2 2 2 1 NYN domain NYN PF01936.13 ESA22410.1 - 3.8e-08 33.7 0.0 7.7e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 NYN domain DUF2414 PF10309.4 ESA22410.1 - 2.5e-07 30.2 1.0 0.02 14.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2414) DUF2522 PF10747.4 ESA22410.1 - 0.0013 18.7 0.1 0.79 9.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2522) NYN PF01936.13 ESA22411.1 - 2.2e-14 53.9 0.0 2.7e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 NYN domain NinG PF05766.7 ESA22413.1 - 0.04 13.6 0.1 0.04 13.6 0.0 2.1 3 0 0 3 3 3 0 Bacteriophage Lambda NinG protein BTB PF00651.26 ESA22414.1 - 2.8e-19 69.1 0.1 5.2e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22414.1 - 4.2e-13 49.4 7.2 4.3e-13 49.4 2.4 2.3 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22414.1 - 2e-08 33.9 6.4 2.5e-07 30.4 0.7 3.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ESA22415.1 - 2.3e-08 34.1 1.1 6.3e-08 32.7 0.8 1.7 1 1 0 1 1 1 1 TLD TLD PF07534.11 ESA22416.1 - 0.028 14.4 0.3 0.031 14.2 0.2 1.1 1 0 0 1 1 1 0 TLD Peptidase_S8 PF00082.17 ESA22418.1 - 8e-39 133.4 12.5 1.1e-38 133.0 8.7 1.1 1 0 0 1 1 1 1 Subtilase family Sel1 PF08238.7 ESA22419.1 - 4.6e-130 421.2 66.6 1.9e-13 50.5 1.0 12.1 12 0 0 12 12 12 12 Sel1 repeat TPR_20 PF14561.1 ESA22419.1 - 0.0009 19.3 13.9 4.8 7.3 0.0 6.6 2 2 6 9 9 9 1 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22419.1 - 0.0015 19.1 9.5 4.5 8.0 0.0 6.1 3 2 4 7 7 7 1 Tetratricopeptide repeat MIT PF04212.13 ESA22419.1 - 0.011 15.5 48.2 0.11 12.4 0.8 10.0 8 3 2 10 10 10 0 MIT (microtubule interacting and transport) domain Flu_M1_C PF08289.6 ESA22419.1 - 0.013 15.4 0.3 11 6.1 0.0 4.7 3 2 2 6 6 6 0 Influenza Matrix protein (M1) C-terminal domain HTH_16 PF12645.2 ESA22419.1 - 0.024 14.5 22.4 0.84 9.6 0.1 7.8 9 0 0 9 9 9 0 Helix-turn-helix domain TPR_6 PF13174.1 ESA22419.1 - 0.063 13.7 31.0 0.57 10.7 0.1 8.0 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22419.1 - 0.064 13.4 38.6 4.6 7.6 0.1 11.7 12 1 0 12 12 12 0 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA22419.1 - 0.37 10.5 21.5 27 4.5 0.0 8.5 11 0 0 11 11 11 0 Lung surfactant protein D coiled-coil trimerisation XkdW PF09636.5 ESA22419.1 - 0.79 9.6 6.5 48 3.8 0.0 4.0 1 1 1 4 4 4 0 XkdW protein DUF3087 PF11286.3 ESA22419.1 - 2.2 7.4 17.0 0.98 8.6 0.1 5.7 4 1 1 6 6 6 0 Protein of unknown function (DUF3087) Glyco_hydro_47 PF01532.15 ESA22421.1 - 5e-167 556.1 0.0 5.9e-167 555.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 EST1_DNA_bind PF10373.4 ESA22422.1 - 1.7e-26 93.0 1.7 1.7e-26 93.0 1.2 2.3 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain PIN_4 PF13638.1 ESA22422.1 - 7.9e-25 87.4 2.6 1.6e-24 86.4 0.1 2.8 2 0 0 2 2 2 1 PIN domain EST1 PF10374.4 ESA22422.1 - 4.1e-06 26.8 5.2 0.00089 19.2 0.1 3.4 3 0 0 3 3 3 2 Telomerase activating protein Est1 Sas10_Utp3 PF04000.10 ESA22423.1 - 6.8e-20 71.0 3.9 6.8e-20 71.0 2.7 2.4 2 0 0 2 2 2 1 Sas10/Utp3/C1D family ApoB100_C PF12491.3 ESA22423.1 - 0.26 10.9 4.4 1.3 8.7 0.8 3.1 1 1 1 2 2 2 0 Apolipoprotein B100 C terminal DUF2935 PF11155.3 ESA22423.1 - 2.1 8.4 9.9 2.9 7.9 0.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) TSC22 PF01166.13 ESA22424.1 - 1.3e-05 25.0 4.5 1.3e-05 25.0 3.1 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family DivIC PF04977.10 ESA22424.1 - 0.0056 16.1 4.9 0.0061 16.0 3.4 1.1 1 0 0 1 1 1 1 Septum formation initiator Shugoshin_N PF07558.6 ESA22424.1 - 0.0061 16.2 1.0 0.014 15.1 0.5 1.7 1 1 1 2 2 2 1 Shugoshin N-terminal coiled-coil region DUF4239 PF14023.1 ESA22424.1 - 0.01 15.1 0.8 0.011 15.0 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF972 PF06156.8 ESA22424.1 - 0.011 16.0 3.5 0.013 15.8 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) HALZ PF02183.13 ESA22424.1 - 0.013 15.1 2.9 0.016 14.8 2.0 1.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.16 ESA22424.1 - 0.071 13.0 3.5 0.087 12.7 2.4 1.3 1 0 0 1 1 1 0 bZIP transcription factor DUF904 PF06005.7 ESA22424.1 - 0.078 13.2 5.1 0.094 13.0 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) M PF02370.11 ESA22424.1 - 0.078 13.3 5.7 0.12 12.8 3.1 2.0 1 1 0 1 1 1 0 M protein repeat Ax_dynein_light PF10211.4 ESA22424.1 - 0.15 11.8 4.6 0.15 11.8 3.2 1.0 1 0 0 1 1 1 0 Axonemal dynein light chain bZIP_2 PF07716.10 ESA22424.1 - 0.17 11.7 6.3 0.15 11.8 3.7 1.6 1 1 0 1 1 1 0 Basic region leucine zipper Spc24 PF08286.6 ESA22424.1 - 0.18 11.4 2.8 0.18 11.5 2.0 1.0 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 BCAS2 PF05700.6 ESA22424.1 - 0.22 10.9 3.3 0.22 10.9 2.3 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) CENP-H PF05837.7 ESA22424.1 - 0.34 11.0 4.2 0.34 11.1 2.9 1.0 1 0 0 1 1 1 0 Centromere protein H (CENP-H) CSTF_C PF14304.1 ESA22424.1 - 0.43 9.8 2.2 0.61 9.4 0.4 2.0 1 1 1 2 2 2 0 Transcription termination and cleavage factor C-terminal ATP-synt_E_2 PF08112.6 ESA22424.1 - 0.98 9.5 3.8 5.1 7.2 0.5 2.1 1 1 1 2 2 2 0 ATP synthase epsilon subunit Pox_A_type_inc PF04508.7 ESA22424.1 - 2.6 8.0 5.0 1.5 8.8 0.3 2.6 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat HTH_29 PF13551.1 ESA22426.1 - 0.078 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix MIB_HERC2 PF06701.8 ESA22427.1 - 0.063 13.2 0.6 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Mib_herc2 Ufd2P_core PF10408.4 ESA22428.1 - 0.13 10.5 0.1 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin elongating factor core Pkinase_Tyr PF07714.12 ESA22431.1 - 7.3e-47 159.6 0.3 6.7e-42 143.3 0.0 4.2 4 1 0 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ESA22431.1 - 1.8e-33 115.8 10.6 7e-33 113.8 2.1 4.1 3 1 0 3 3 3 1 Protein kinase domain BCS1_N PF08740.6 ESA22431.1 - 0.00088 18.9 0.0 0.83 9.2 0.0 4.0 4 0 0 4 4 4 1 BCS1 N terminal CLTH PF10607.4 ESA22431.1 - 0.0022 17.6 5.1 2.9 7.5 0.0 4.5 4 1 0 4 4 4 2 CTLH/CRA C-terminal to LisH motif domain DUF4339 PF14237.1 ESA22431.1 - 0.0049 16.4 0.0 6.4 6.4 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4339) dNK PF01712.14 ESA22432.1 - 0.056 13.3 1.5 0.28 11.0 0.3 2.0 1 1 1 2 2 2 0 Deoxynucleoside kinase F-box-like PF12937.2 ESA22433.1 - 0.0038 16.9 1.1 0.0079 15.9 0.2 2.0 2 0 0 2 2 2 1 F-box-like DUF4218 PF13960.1 ESA22434.1 - 0.00012 21.5 0.0 0.00031 20.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Elong_Iki1 PF10483.4 ESA22435.1 - 1.3e-13 50.9 5.3 8.3e-10 38.4 0.2 2.1 1 1 1 2 2 2 2 Elongator subunit Iki1 YrzO PF14142.1 ESA22435.1 - 0.031 13.9 1.7 0.076 12.6 0.1 2.1 2 0 0 2 2 2 0 YrzO-like protein BTB_2 PF02214.17 ESA22436.1 - 5.8e-17 61.6 0.6 3.7e-07 30.2 0.0 3.6 4 0 0 4 4 4 3 BTB/POZ domain BTB PF00651.26 ESA22436.1 - 7.8e-05 22.6 0.1 0.018 15.0 0.0 2.6 2 1 0 2 2 2 2 BTB/POZ domain ArsA_ATPase PF02374.10 ESA22437.1 - 3.4e-111 371.1 0.7 4e-111 370.9 0.5 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 ESA22437.1 - 2e-15 56.7 0.1 4.9e-15 55.4 0.1 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 ESA22437.1 - 1e-08 35.3 0.0 2.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 ESA22437.1 - 2.6e-05 23.5 0.0 9.3e-05 21.7 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 ESA22437.1 - 4.3e-05 23.0 0.7 0.0011 18.5 0.1 2.3 1 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.1 ESA22437.1 - 6.4e-05 22.4 0.0 0.00026 20.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain YhjQ PF06564.7 ESA22437.1 - 0.013 14.9 0.0 0.023 14.0 0.0 1.5 1 1 0 1 1 1 0 YhjQ protein MipZ PF09140.6 ESA22437.1 - 0.017 14.1 0.2 0.035 13.1 0.1 1.6 1 1 1 2 2 2 0 ATPase MipZ NB-ARC PF00931.17 ESA22437.1 - 0.021 13.7 0.0 0.035 12.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.1 ESA22437.1 - 0.021 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 ESA22437.1 - 0.034 13.8 0.0 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain PhoH PF02562.11 ESA22437.1 - 0.077 12.2 0.0 0.23 10.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.7 ESA22437.1 - 0.093 11.8 0.0 0.27 10.2 0.0 1.7 1 1 1 2 2 2 0 Zeta toxin RNA_helicase PF00910.17 ESA22437.1 - 0.1 12.7 0.0 4.1 7.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.12 ESA22437.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad52_Rad22 PF04098.10 ESA22438.1 - 1.4e-37 128.7 0.0 1.7e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein BTB PF00651.26 ESA22439.1 - 1.3e-18 67.0 0.1 2.3e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22439.1 - 2e-09 37.1 11.7 8.3e-08 32.0 0.3 5.0 4 2 2 6 6 6 2 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA22439.1 - 0.015 14.5 0.3 0.022 13.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Glycos_transf_1 PF00534.15 ESA22440.1 - 1.1e-36 125.8 0.0 5e-36 123.7 0.0 2.0 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESA22440.1 - 5.4e-08 32.7 0.1 1.2e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 ESA22440.1 - 1.6e-07 31.6 0.0 2.3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 ESA22440.1 - 3.1e-06 27.3 0.0 2.2e-05 24.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 ESA22440.1 - 8.9e-05 22.6 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Helitron_like_N PF14214.1 ESA22442.1 - 2.1e-20 73.2 0.8 2.4e-10 40.4 0.0 2.3 1 1 1 2 2 2 2 Helitron helicase-like domain at N-terminus CtsR PF05848.6 ESA22442.1 - 0.051 13.5 0.4 0.065 13.1 0.2 1.1 1 0 0 1 1 1 0 Firmicute transcriptional repressor of class III stress genes (CtsR) AAA-ATPase_like PF09820.4 ESA22444.1 - 6.1e-40 137.1 8.9 1.4e-20 73.6 0.5 2.5 2 1 1 3 3 3 2 Predicted AAA-ATPase Laminin_EGF PF00053.19 ESA22445.1 - 1.5 8.8 8.3 0.094 12.6 1.7 2.1 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) GATA PF00320.22 ESA22446.1 - 6.1e-19 67.0 3.1 7.3e-19 66.8 2.1 1.1 1 0 0 1 1 1 1 GATA zinc finger DZR PF12773.2 ESA22446.1 - 0.0033 17.1 0.3 0.0051 16.5 0.2 1.5 1 1 0 1 1 1 1 Double zinc ribbon TF_Zn_Ribbon PF08271.7 ESA22446.1 - 0.071 12.4 0.3 0.09 12.1 0.2 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding GSu_C4xC__C2xCH PF09698.5 ESA22446.1 - 0.35 11.0 4.9 2.7 8.2 3.4 2.0 1 1 0 1 1 1 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) DUF572 PF04502.8 ESA22447.1 - 3.6 6.7 11.6 4.2 6.5 8.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pkinase PF00069.20 ESA22448.1 - 2.7e-29 102.0 0.1 2.9e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22448.1 - 2.6e-22 79.1 0.0 2.9e-22 78.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA22448.1 - 0.00022 20.6 0.0 0.00024 20.5 0.0 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA22448.1 - 0.0011 18.8 0.1 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA22448.1 - 0.0099 15.1 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA22448.1 - 0.013 14.6 0.0 0.016 14.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.15 ESA22448.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase Bax1-I PF01027.15 ESA22449.1 - 5.2e-47 160.0 33.1 6.1e-47 159.8 22.9 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Iron_permease PF04120.7 ESA22449.1 - 0.12 11.9 1.2 0.27 10.8 0.8 1.5 1 0 0 1 1 1 0 Low affinity iron permease Shugoshin_N PF07558.6 ESA22450.1 - 0.0017 18.0 4.2 0.0048 16.5 2.9 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DUF972 PF06156.8 ESA22450.1 - 0.002 18.4 8.5 0.002 18.4 5.9 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF972) CENP-F_leu_zip PF10473.4 ESA22450.1 - 0.017 14.9 14.5 0.017 14.9 10.1 1.8 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.14 ESA22450.1 - 0.024 14.1 16.4 0.077 12.5 11.1 1.9 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Microtub_assoc PF07989.6 ESA22450.1 - 0.099 12.4 7.6 0.74 9.6 2.4 3.5 2 1 1 3 3 3 0 Microtubule associated IncA PF04156.9 ESA22450.1 - 1.5 8.3 20.1 0.076 12.6 9.1 2.2 2 0 0 2 2 2 0 IncA protein ATG16 PF08614.6 ESA22450.1 - 2.8 7.7 19.2 0.64 9.8 7.9 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 ESA22450.1 - 3.6 7.3 18.0 0.37 10.5 8.9 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.14 ESA22450.1 - 7.9 4.1 13.2 1.2 6.8 6.1 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESA22450.1 - 9.2 5.2 18.0 0.47 9.4 6.8 2.3 2 0 0 2 2 2 0 Autophagy protein Apg6 HMG_box PF00505.14 ESA22451.1 - 0.00031 20.9 0.0 0.00049 20.3 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box Unstab_antitox PF09720.5 ESA22451.1 - 0.002 17.7 0.1 0.014 15.0 0.0 2.0 2 0 0 2 2 2 1 Putative addiction module component CWC25 PF12542.3 ESA22452.1 - 0.38 11.2 4.6 0.42 11.0 3.2 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor TRAP_alpha PF03896.11 ESA22452.1 - 1 8.3 6.4 1.1 8.1 4.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4637 PF15470.1 ESA22452.1 - 1.8 8.1 6.6 2 7.9 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CAF1A PF12253.3 ESA22452.1 - 6.4 6.9 12.1 13 5.9 8.4 1.5 1 1 0 1 1 1 0 Chromatin assembly factor 1 subunit A gag-asp_proteas PF13975.1 ESA22453.1 - 0.036 13.8 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Rootletin PF15035.1 ESA22454.1 - 0.015 15.3 4.0 0.03 14.3 2.8 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF904 PF06005.7 ESA22454.1 - 0.022 15.0 2.6 0.022 15.0 1.8 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF904) Herpes_BLRF2 PF05812.7 ESA22454.1 - 0.038 13.8 1.2 0.086 12.6 0.9 1.7 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Mto2_bdg PF12808.2 ESA22454.1 - 0.071 13.2 5.8 3.7 7.7 0.5 2.5 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_1 PF00170.16 ESA22454.1 - 0.088 12.7 4.6 0.21 11.5 3.0 1.8 1 1 1 2 2 2 0 bZIP transcription factor DivIC PF04977.10 ESA22454.1 - 0.15 11.5 4.2 2.8 7.4 2.9 2.6 1 1 0 1 1 1 0 Septum formation initiator Shugoshin_N PF07558.6 ESA22454.1 - 0.23 11.1 3.8 0.2 11.3 0.9 2.1 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.10 ESA22454.1 - 0.44 10.4 5.8 0.37 10.6 1.0 2.3 1 1 1 2 2 2 0 Basic region leucine zipper TSC22 PF01166.13 ESA22454.1 - 0.49 10.3 4.9 1.9 8.5 3.4 2.0 1 1 0 1 1 1 0 TSC-22/dip/bun family DUF972 PF06156.8 ESA22454.1 - 0.64 10.3 4.0 0.36 11.2 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Tup_N PF08581.5 ESA22454.1 - 0.83 9.8 5.4 0.48 10.6 1.7 2.2 2 1 0 2 2 2 0 Tup N-terminal DUF2570 PF10828.3 ESA22454.1 - 1 8.9 3.5 2.3 7.8 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) IncA PF04156.9 ESA22454.1 - 8.9 5.8 6.8 0.9 9.1 1.4 1.8 2 0 0 2 2 2 0 IncA protein CRT-like PF08627.5 ESA22455.1 - 0.052 13.4 0.7 0.071 13.0 0.5 1.2 1 0 0 1 1 1 0 CRT-like DUF3671 PF12420.3 ESA22455.1 - 0.082 12.8 2.0 0.098 12.6 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function DHQ_synthase PF01761.15 ESA22456.1 - 2.2e-92 308.7 0.0 3e-92 308.2 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase EPSP_synthase PF00275.15 ESA22456.1 - 2.1e-50 171.3 0.3 4.2e-50 170.3 0.2 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Fe-ADH_2 PF13685.1 ESA22456.1 - 7.1e-11 41.8 0.0 2.4e-10 40.1 0.0 1.9 2 1 0 2 2 2 1 Iron-containing alcohol dehydrogenase tRNA_synt_1c_R1 PF04558.10 ESA22456.1 - 0.0067 15.9 0.4 0.014 14.8 0.3 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Fe-ADH PF00465.14 ESA22456.1 - 0.14 10.7 2.6 1.6 7.3 1.8 2.1 1 1 0 1 1 1 0 Iron-containing alcohol dehydrogenase EPSP_synthase PF00275.15 ESA22457.1 - 4.5e-125 417.3 0.1 6.7e-125 416.8 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 ESA22457.1 - 3.7e-97 324.3 0.0 5.4e-97 323.7 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 ESA22457.1 - 4.6e-09 35.9 0.0 1.2e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 ESA22457.1 - 0.011 14.3 0.2 0.82 8.2 0.1 2.3 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase tRNA_synt_1c_R1 PF04558.10 ESA22457.1 - 0.012 15.1 0.5 0.031 13.7 0.3 1.6 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 AAA-ATPase_like PF09820.4 ESA22458.1 - 9.8e-60 202.1 3.7 1.8e-59 201.2 2.6 1.4 1 0 0 1 1 1 1 Predicted AAA-ATPase DUF1703 PF08011.6 ESA22458.1 - 3.6e-13 49.1 1.0 7.8e-13 48.0 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1703) BTB PF00651.26 ESA22459.1 - 4.5e-12 45.9 0.1 9.8e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22459.1 - 1.1e-10 41.2 7.6 1.1e-08 34.8 0.8 4.0 2 1 2 4 4 4 2 BTB And C-terminal Kelch Skp1_POZ PF03931.10 ESA22459.1 - 0.074 13.1 0.1 0.26 11.4 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain SNF2_N PF00176.18 ESA22460.1 - 7.7e-72 241.6 1.6 7.7e-72 241.6 1.1 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.1 ESA22460.1 - 1.1e-49 168.0 22.9 1.1e-49 168.0 15.9 4.7 3 2 2 5 5 5 1 DNA-binding domain Helicase_C PF00271.26 ESA22460.1 - 3.1e-14 52.6 0.0 8.4e-14 51.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CsbD PF05532.7 ESA22461.1 - 0.0011 18.5 0.4 0.002 17.7 0.2 1.3 1 0 0 1 1 1 1 CsbD-like 120_Rick_ant PF12574.3 ESA22463.1 - 0.058 12.4 1.1 0.078 12.0 0.4 1.5 1 1 0 1 1 1 0 120 KDa Rickettsia surface antigen rRNA_methylase PF06962.7 ESA22467.1 - 0.0046 16.6 0.5 3.9 7.1 0.0 3.7 4 1 1 5 5 5 2 Putative rRNA methylase DZR PF12773.2 ESA22467.1 - 0.19 11.5 6.1 2 8.2 0.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon DnaJ_CXXCXGXG PF00684.14 ESA22467.1 - 1.2 9.2 6.2 3.1 7.9 0.2 2.3 2 0 0 2 2 2 0 DnaJ central domain Prp18 PF02840.10 ESA22468.1 - 0.00044 20.0 0.2 0.39 10.5 0.0 2.2 2 0 0 2 2 2 2 Prp18 domain BCS1_N PF08740.6 ESA22468.1 - 0.0032 17.1 0.3 0.47 10.0 0.0 2.6 2 1 1 3 3 3 2 BCS1 N terminal MSC PF09402.5 ESA22468.1 - 0.017 13.8 2.6 0.91 8.1 0.1 2.2 1 1 0 2 2 2 0 Man1-Src1p-C-terminal domain IRS PF02174.12 ESA22468.1 - 0.025 14.1 0.0 2.4 7.7 0.0 2.2 2 0 0 2 2 2 0 PTB domain (IRS-1 type) Glyco_hydro_11 PF00457.12 ESA22468.1 - 0.041 13.2 4.5 2.4 7.4 0.7 2.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 11 HMG_box PF00505.14 ESA22469.1 - 0.036 14.3 0.0 0.089 13.0 0.0 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box DUF3450 PF11932.3 ESA22471.1 - 0.00092 18.5 5.0 0.23 10.6 0.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3450) DUF972 PF06156.8 ESA22471.1 - 3.6 7.9 14.0 0.61 10.4 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.9 ESA22471.1 - 5.9 6.4 13.6 7.5 6.0 3.1 2.2 2 0 0 2 2 2 0 IncA protein Myc-LZ PF02344.10 ESA22472.1 - 0.69 9.5 5.2 1.3 8.7 0.1 2.6 2 0 0 2 2 2 0 Myc leucine zipper domain Hemocyanin_C PF03723.9 ESA22473.1 - 3.3e-35 121.4 0.0 5.7e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Hemocyanin, ig-like domain Hemocyanin_M PF00372.14 ESA22473.1 - 2.1e-33 115.8 0.1 3e-33 115.2 0.1 1.2 1 0 0 1 1 1 1 Hemocyanin, copper containing domain Tyrosinase PF00264.15 ESA22473.1 - 1.7e-10 41.4 0.5 1.7e-10 41.4 0.3 2.4 1 1 1 2 2 2 1 Common central domain of tyrosinase F-box-like PF12937.2 ESA22474.1 - 0.0089 15.7 0.4 0.0089 15.7 0.2 2.8 3 0 0 3 3 3 1 F-box-like MAS20 PF02064.10 ESA22474.1 - 0.05 13.5 0.1 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 MAS20 protein import receptor RRM_1 PF00076.17 ESA22475.1 - 4.1e-05 23.1 0.0 7.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1777 PF08648.7 ESA22475.1 - 0.04 13.6 15.4 0.083 12.6 10.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1777) RRM_6 PF14259.1 ESA22475.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Apis_Csd PF11671.3 ESA22475.1 - 2 8.2 15.5 1.2 8.8 9.1 1.9 2 0 0 2 2 2 0 Complementary sex determiner protein DUF2999 PF11212.3 ESA22478.1 - 0.072 13.1 0.0 24 5.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) Sel1 PF08238.7 ESA22479.1 - 2.6e-145 469.6 50.5 1.4e-13 50.9 0.5 13.0 13 0 0 13 13 13 13 Sel1 repeat TPR_6 PF13174.1 ESA22479.1 - 4.2e-06 26.8 7.3 4.7 7.8 0.0 7.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22479.1 - 1e-05 26.0 3.3 14 6.5 0.0 6.3 5 3 2 7 7 7 1 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA22479.1 - 3.5e-05 23.7 0.0 33 4.5 0.0 6.9 2 2 6 9 9 9 0 Influenza Matrix protein (M1) C-terminal domain NUMOD1 PF07453.8 ESA22479.1 - 0.003 17.3 7.0 12 5.9 0.0 6.5 5 1 1 6 6 6 1 NUMOD1 domain MA3 PF02847.12 ESA22479.1 - 0.069 12.8 0.1 14 5.4 0.0 2.6 3 0 0 3 3 3 0 MA3 domain SCHIP-1 PF10148.4 ESA22479.1 - 0.07 12.5 0.4 6.8 6.0 0.0 3.4 3 0 0 3 3 3 0 Schwannomin-interacting protein 1 DUF2530 PF10745.4 ESA22479.1 - 0.11 12.4 0.0 1.3e+02 2.6 0.0 4.9 8 0 0 8 8 8 0 Protein of unknown function (DUF2530) SinI PF08671.5 ESA22479.1 - 0.61 9.5 16.0 19 4.7 0.1 6.4 7 0 0 7 7 7 0 Anti-repressor SinI Leuk-A4-hydro_C PF09127.6 ESA22479.1 - 0.74 9.4 7.3 0.85 9.2 0.3 3.7 2 2 0 3 3 3 0 Leukotriene A4 hydrolase, C-terminal Sel1 PF08238.7 ESA22480.1 - 4.6e-10 39.8 6.7 6e-09 36.2 0.2 2.3 2 0 0 2 2 2 2 Sel1 repeat CobT_C PF11775.3 ESA22480.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain BTB PF00651.26 ESA22481.1 - 2e-18 66.4 0.1 3.1e-18 65.7 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22481.1 - 0.0045 16.8 2.4 1 9.2 0.1 3.2 2 1 1 3 3 3 2 BTB And C-terminal Kelch CEP44 PF15007.1 ESA22481.1 - 0.047 13.3 1.3 0.11 12.2 0.9 1.6 1 0 0 1 1 1 0 Centrosomal spindle body, CEP44 BTB PF00651.26 ESA22482.1 - 1.8e-07 31.0 0.0 2.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA22483.1 - 1.4e-18 66.8 0.2 2.6e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22483.1 - 1.5e-09 37.9 0.3 2.8e-09 37.0 0.2 1.5 1 0 0 1 1 1 1 TLD DUF3342 PF11822.3 ESA22483.1 - 0.1 11.7 0.4 0.16 11.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) BTB PF00651.26 ESA22484.1 - 3.2e-20 72.1 0.1 4.5e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.3 ESA22484.1 - 0.012 14.7 0.2 0.014 14.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) CEP44 PF15007.1 ESA22484.1 - 0.16 11.6 1.8 0.15 11.7 0.4 1.6 2 0 0 2 2 2 0 Centrosomal spindle body, CEP44 Dimer_Tnp_hAT PF05699.9 ESA22485.1 - 1.1e-11 44.1 0.1 1.2e-11 44.0 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Dimer_Tnp_hAT PF05699.9 ESA22486.1 - 1.6e-15 56.4 0.1 1.7e-15 56.3 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA22487.1 - 0.012 15.6 0.2 0.021 14.7 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4413) DUF1577 PF07614.6 ESA22488.1 - 0.045 12.6 1.0 0.068 12.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) Pico_P2A PF00947.14 ESA22489.1 - 0.0037 17.0 0.2 0.0057 16.4 0.1 1.3 1 0 0 1 1 1 1 Picornavirus core protein 2A DUF2051 PF09738.4 ESA22489.1 - 0.097 11.9 1.0 0.14 11.4 0.7 1.2 1 0 0 1 1 1 0 Double stranded RNA binding protein (DUF2051) BCS1_N PF08740.6 ESA22491.1 - 2.4e-05 24.0 0.4 2 7.9 0.0 4.2 3 1 0 4 4 4 2 BCS1 N terminal Prp18 PF02840.10 ESA22491.1 - 0.00054 19.7 0.1 2.9 7.6 0.0 3.1 3 0 0 3 3 3 2 Prp18 domain Abhydrolase_2 PF02230.11 ESA22491.1 - 0.041 13.3 1.2 3.8 6.8 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Pkinase_Tyr PF07714.12 ESA22492.1 - 1.3e-23 83.4 0.0 1.4e-23 83.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22492.1 - 7.3e-23 81.0 0.7 1.3e-22 80.1 0.5 1.4 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA22492.1 - 0.0021 17.7 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal APH PF01636.18 ESA22492.1 - 0.071 12.8 0.2 0.11 12.1 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family ubiquitin PF00240.18 ESA22493.1 - 8.4e-05 21.8 0.1 0.00023 20.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.4 ESA22493.1 - 0.00026 21.1 0.3 0.00042 20.4 0.2 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.3 ESA22493.1 - 0.011 15.4 0.3 0.017 14.8 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UPF0061 PF02696.9 ESA22494.1 - 4.5e-128 427.5 0.0 5.4e-128 427.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Kdo PF06293.9 ESA22494.1 - 0.016 14.2 0.0 0.036 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Histone PF00125.19 ESA22495.1 - 1.3e-06 28.4 0.1 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF1616 PF07760.6 ESA22496.1 - 0.044 12.9 1.7 0.06 12.4 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Kinetocho_Slk19 PF12709.2 ESA22496.1 - 0.087 12.9 0.9 0.087 12.9 0.6 3.4 3 1 0 3 3 3 0 Central kinetochore-associated S-AdoMet_synt_N PF00438.15 ESA22496.1 - 0.69 10.1 4.6 0.44 10.7 1.9 1.6 1 1 1 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain DNA_repr_REX1B PF14966.1 ESA22496.1 - 0.86 10.0 6.9 0.7 10.3 0.1 2.8 2 1 0 3 3 3 0 DNA repair REX1-B EMP70 PF02990.11 ESA22496.1 - 1.3 7.4 4.4 1.5 7.2 3.0 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 UvrD_C_2 PF13538.1 ESA22497.1 - 0.0035 17.4 0.0 0.0039 17.3 0.0 1.1 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.9 ESA22497.1 - 0.014 13.1 0.0 0.015 13.0 0.0 1.0 1 0 0 1 1 1 0 Helicase ERp29_N PF07912.8 ESA22498.1 - 0.027 14.4 0.1 0.066 13.1 0.1 1.7 1 0 0 1 1 1 0 ERp29, N-terminal domain Phage_holin_T PF11031.3 ESA22498.1 - 0.095 11.8 5.6 0.11 11.5 1.4 2.3 1 1 1 2 2 2 0 Bacteriophage T holin Baculo_p26 PF04766.7 ESA22499.1 - 0.013 14.7 0.2 0.024 13.9 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus p26 protein F-box-like PF12937.2 ESA22499.1 - 0.016 14.9 0.2 0.016 14.9 0.2 2.2 2 0 0 2 2 2 0 F-box-like His_kinase PF06580.8 ESA22500.1 - 0.097 12.6 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Histidine kinase GatB_N PF02934.10 ESA22501.1 - 0.2 10.5 1.2 0.21 10.4 0.8 1.0 1 0 0 1 1 1 0 GatB/GatE catalytic domain F-box-like PF12937.2 ESA22502.1 - 0.017 14.8 0.3 0.053 13.2 0.2 1.8 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.2 ESA22503.1 - 0.0027 17.3 0.7 0.0091 15.7 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA22504.1 - 0.0013 18.4 0.5 0.0028 17.3 0.3 1.5 1 0 0 1 1 1 1 F-box-like RVT_1 PF00078.22 ESA22505.1 - 2.2e-06 27.1 0.2 2.3e-06 27.1 0.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1319 PF07028.6 ESA22505.1 - 0.1 12.8 0.4 0.12 12.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) RNase_H PF00075.19 ESA22507.1 - 8e-08 32.6 0.2 2.2e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 RNase H Rubredoxin PF00301.15 ESA22507.1 - 0.019 14.8 1.2 0.047 13.5 0.9 1.6 1 0 0 1 1 1 0 Rubredoxin zf-TAZ PF02135.11 ESA22507.1 - 0.12 12.4 2.6 0.25 11.3 1.8 1.5 1 0 0 1 1 1 0 TAZ zinc finger RicinB_lectin_2 PF14200.1 ESA22508.1 - 8.4e-06 26.1 0.3 0.1 12.9 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.17 ESA22508.1 - 0.00017 21.6 0.2 0.28 11.2 0.0 2.4 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain Pkinase PF00069.20 ESA22509.1 - 0.00013 21.2 0.3 0.00023 20.3 0.2 1.4 1 1 0 1 1 1 1 Protein kinase domain VWA PF00092.23 ESA22510.1 - 3.9e-13 49.4 0.0 6.1e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 ESA22510.1 - 2.8e-12 47.0 0.0 4.7e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 ESA22510.1 - 0.0001 21.5 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.1 ESA22510.1 - 0.065 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain vWA-TerF-like PF10138.4 ESA22510.1 - 0.077 12.8 0.0 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 vWA found in TerF C terminus Borrelia_orfA PF02414.10 ESA22511.1 - 0.014 14.4 0.3 0.017 14.2 0.2 1.0 1 0 0 1 1 1 0 Borrelia ORF-A VWA_2 PF13519.1 ESA22513.1 - 6.3e-12 45.9 0.0 9.2e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA22513.1 - 3.8e-10 39.7 0.1 5.9e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 ESA22513.1 - 0.0021 17.2 0.0 0.045 12.8 0.0 2.1 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein DUF2201 PF09967.4 ESA22513.1 - 0.01 15.8 0.0 0.033 14.1 0.0 1.8 2 0 0 2 2 2 0 VWA-like domain (DUF2201) Flu_PB1 PF00602.12 ESA22515.1 - 0.1 10.3 0.1 0.13 9.9 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Mucin PF01456.12 ESA22516.1 - 0.045 13.5 17.1 0.054 13.2 11.9 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Shisa PF13908.1 ESA22516.1 - 2.1 8.5 7.7 6.5 6.9 0.8 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator EF-hand_7 PF13499.1 ESA22517.1 - 5.5e-20 71.2 19.3 3.6e-07 30.2 2.1 3.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 ESA22517.1 - 7.3e-17 59.3 17.3 9.8e-05 21.3 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 ESA22517.1 - 1.5e-14 52.4 14.2 0.0011 18.6 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 ESA22517.1 - 2.3e-10 39.9 10.0 0.0043 16.6 0.4 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA22517.1 - 2.9e-10 38.9 14.9 0.0012 18.1 0.2 4.7 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.2 ESA22517.1 - 4.5e-07 29.5 3.3 0.046 13.4 0.1 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA22517.1 - 7.5e-07 29.1 0.1 0.00036 20.5 0.0 2.6 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 ESA22517.1 - 0.018 14.7 2.4 1.1 9.0 0.1 3.2 2 1 1 3 3 3 0 EF hand SieB PF14163.1 ESA22517.1 - 0.031 13.8 0.1 0.05 13.1 0.1 1.2 1 0 0 1 1 1 0 Superinfection exclusion protein B Ten1_2 PF15490.1 ESA22517.1 - 0.12 11.9 0.2 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit DUF3853 PF12964.2 ESA22518.1 - 0.3 10.9 2.2 0.31 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) Pox_polyA_pol_N PF12630.2 ESA22519.1 - 0.049 13.7 2.7 0.082 13.0 1.9 1.4 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain DUF3922 PF13059.1 ESA22519.1 - 0.096 12.8 0.1 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) Ecl1 PF12855.2 ESA22519.1 - 0.28 10.5 2.6 0.81 9.0 1.8 1.8 1 1 0 1 1 1 0 Life-span regulatory factor Exo_endo_phos PF03372.18 ESA22520.1 - 5.4e-11 42.8 0.0 8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 ESA22520.1 - 7.7e-11 41.6 0.4 7.7e-11 41.6 0.2 2.3 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Peptidase_S15 PF02129.13 ESA22520.1 - 0.0054 16.1 0.2 0.017 14.5 0.1 1.8 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Sel1 PF08238.7 ESA22522.1 - 1.1e-33 114.9 9.1 4.8e-11 42.9 0.0 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_17 PF13431.1 ESA22522.1 - 0.00019 21.3 1.5 0.065 13.4 0.1 3.8 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22522.1 - 0.00023 21.3 5.4 0.034 14.6 0.0 3.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22522.1 - 0.002 17.7 6.2 0.065 12.8 2.2 2.4 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 ESA22522.1 - 0.0023 17.4 7.7 0.64 9.7 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 ESA22522.1 - 0.019 14.8 6.9 0.55 10.1 0.2 2.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA22522.1 - 0.04 13.6 0.2 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation TPR_2 PF07719.12 ESA22522.1 - 0.15 12.0 12.4 2.4 8.3 0.1 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22522.1 - 0.35 10.8 2.9 1 9.3 0.7 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat MRP-L46 PF11788.3 ESA22522.1 - 2 9.0 3.8 20 5.9 0.7 2.4 2 1 0 2 2 2 0 39S mitochondrial ribosomal protein L46 Sel1 PF08238.7 ESA22523.1 - 1e-34 118.1 17.8 8.5e-14 51.6 0.3 4.0 4 0 0 4 4 4 4 Sel1 repeat TPR_17 PF13431.1 ESA22523.1 - 0.0013 18.8 3.3 0.69 10.2 0.3 4.2 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22523.1 - 0.023 15.1 5.1 0.29 11.6 0.0 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22523.1 - 0.12 12.0 10.0 0.36 10.5 1.0 2.6 1 1 2 3 3 3 0 TPR repeat Surfac_D-trimer PF09006.6 ESA22523.1 - 0.16 11.7 1.3 9.4 6.0 0.0 2.5 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation MIT PF04212.13 ESA22523.1 - 0.17 11.7 11.3 0.89 9.4 0.3 3.4 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 ESA22523.1 - 0.35 10.8 1.6 2.1 8.4 0.4 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22523.1 - 0.59 10.0 6.7 1.9 8.4 2.0 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA22523.1 - 1.7 8.3 19.1 15 5.3 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22523.1 - 7.3 6.7 18.0 17 5.6 0.3 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat ArfGap PF01412.13 ESA22524.1 - 1.7e-30 105.2 8.8 2.9e-30 104.4 0.2 3.3 4 0 0 4 4 4 2 Putative GTPase activating protein for Arf PH PF00169.24 ESA22524.1 - 7.6e-14 51.7 0.1 2.7e-13 50.0 0.1 2.0 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 ESA22524.1 - 0.031 14.4 0.2 0.31 11.2 0.1 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain AAA PF00004.24 ESA22525.1 - 1.2e-42 145.2 0.0 2e-42 144.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA22525.1 - 3.2e-07 30.5 0.1 8.8e-06 25.8 0.0 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 ESA22525.1 - 4e-07 29.8 0.2 1.4e-05 24.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 ESA22525.1 - 1.2e-06 28.5 0.0 6e-06 26.2 0.0 2.1 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 ESA22525.1 - 2.8e-06 27.5 0.0 0.001 19.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 ESA22525.1 - 8.1e-06 25.0 0.0 1.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 ESA22525.1 - 0.00019 21.0 0.0 0.00042 20.0 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF815 PF05673.8 ESA22525.1 - 0.00038 19.4 0.1 0.0016 17.3 0.0 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_33 PF13671.1 ESA22525.1 - 0.00051 19.9 0.0 0.006 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 ESA22525.1 - 0.00067 20.4 0.7 0.0028 18.4 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.1 ESA22525.1 - 0.0014 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 ESA22525.1 - 0.002 17.3 0.0 0.0043 16.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 ESA22525.1 - 0.003 16.3 0.0 0.0056 15.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 ESA22525.1 - 0.0032 16.9 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 ESA22525.1 - 0.0044 17.3 0.1 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESA22525.1 - 0.0051 16.4 0.1 0.012 15.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 ESA22525.1 - 0.0052 16.9 0.0 0.0099 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Thymidylate_kin PF02223.12 ESA22525.1 - 0.0068 15.8 0.1 1.6 8.0 0.0 2.5 2 0 0 2 2 2 1 Thymidylate kinase Sigma54_activat PF00158.21 ESA22525.1 - 0.0084 15.5 0.0 0.029 13.8 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 ESA22525.1 - 0.0091 15.1 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_3 PF07726.6 ESA22525.1 - 0.0098 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 ESA22525.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESA22525.1 - 0.027 13.8 0.2 0.1 11.9 0.1 1.9 1 1 1 2 2 2 0 AAA domain DUF4200 PF13863.1 ESA22525.1 - 0.027 14.4 2.0 0.027 14.4 1.4 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) NACHT PF05729.7 ESA22525.1 - 0.029 14.0 0.1 0.076 12.6 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.11 ESA22525.1 - 0.031 13.5 0.0 0.063 12.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.10 ESA22525.1 - 0.036 13.9 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_30 PF13604.1 ESA22525.1 - 0.037 13.6 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 ESA22525.1 - 0.04 13.0 0.6 0.13 11.3 0.0 2.1 3 0 0 3 3 2 0 KaiC Sigma54_activ_2 PF14532.1 ESA22525.1 - 0.047 13.7 0.0 0.13 12.2 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 ESA22525.1 - 0.053 13.2 0.2 0.19 11.3 0.0 2.0 2 1 0 2 2 1 0 Archaeal ATPase UPF0079 PF02367.12 ESA22525.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 ESA22525.1 - 0.06 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 ESA22525.1 - 0.1 12.1 0.2 0.35 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain CPT PF07931.7 ESA22525.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.1 ESA22525.1 - 1.1 9.5 6.1 7.9 6.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain SAP PF02037.22 ESA22526.1 - 6.8e-12 44.5 1.0 6.8e-12 44.5 0.7 2.5 2 0 0 2 2 2 1 SAP domain Telomere_Sde2_2 PF13297.1 ESA22526.1 - 3.9 6.8 8.1 2.8 7.2 0.0 4.0 4 0 0 4 4 4 0 Telomere stability C-terminal VirionAssem_T7 PF11653.3 ESA22526.1 - 6.2 7.6 15.3 0.25 12.0 0.2 3.9 1 1 3 4 4 4 0 Bacteriophage T7 virion assembly protein 6PF2K PF01591.13 ESA22527.1 - 6.2e-72 241.2 0.5 8.7e-72 240.7 0.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 ESA22527.1 - 3e-29 102.1 0.1 2.8e-28 98.9 0.0 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 ESA22527.1 - 3.5e-07 30.1 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 ESA22527.1 - 0.0084 16.9 0.2 0.03 15.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 ESA22527.1 - 0.023 13.8 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ComZ PF10815.3 ESA22528.1 - 0.029 14.1 0.0 2.1 8.1 0.0 2.1 2 0 0 2 2 2 0 ComZ UPF0240 PF06784.6 ESA22529.1 - 1.6e-08 34.4 0.0 1.9e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0240) HTH_11 PF08279.7 ESA22529.1 - 0.042 13.4 0.4 0.071 12.7 0.1 1.5 2 0 0 2 2 2 0 HTH domain MRP-L20 PF12824.2 ESA22529.1 - 0.044 13.7 0.0 0.044 13.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 FeoC PF09012.5 ESA22529.1 - 0.046 13.4 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator EST1_DNA_bind PF10373.4 ESA22531.1 - 3.4e-26 92.0 5.6 7.3e-26 91.0 3.9 1.6 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.4 ESA22531.1 - 2.8e-13 50.0 0.4 2.8e-13 50.0 0.3 2.8 3 0 0 3 3 3 1 Telomerase activating protein Est1 PIN_4 PF13638.1 ESA22531.1 - 3.5e-09 36.8 0.7 3.5e-09 36.8 0.5 3.6 3 1 0 3 3 3 1 PIN domain Prefoldin_3 PF13758.1 ESA22532.1 - 0.0013 18.4 1.0 0.0032 17.2 0.6 1.7 1 1 0 1 1 1 1 Prefoldin subunit FadA PF09403.5 ESA22532.1 - 0.093 12.7 1.4 1.7 8.6 0.6 2.0 1 1 1 2 2 2 0 Adhesion protein FadA Nsp1_C PF05064.8 ESA22532.1 - 0.11 12.1 0.7 0.15 11.7 0.1 1.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region Phage_GP20 PF06810.6 ESA22532.1 - 0.13 11.7 1.9 0.21 11.0 0.5 1.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 Syntaxin_2 PF14523.1 ESA22532.1 - 0.23 11.5 1.7 2.5 8.1 1.2 2.2 1 1 0 1 1 1 0 Syntaxin-like protein SKIP_SNW PF02731.10 ESA22534.1 - 0.12 11.7 0.1 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 SKIP/SNW domain BCS1_N PF08740.6 ESA22535.1 - 0.00055 19.6 0.1 0.26 10.8 0.0 2.4 2 0 0 2 2 2 2 BCS1 N terminal Prp18 PF02840.10 ESA22535.1 - 0.0034 17.1 0.5 0.28 11.0 0.0 2.3 2 0 0 2 2 2 2 Prp18 domain CI-B14_5a PF07347.7 ESA22535.1 - 0.11 12.3 0.2 0.43 10.3 0.0 2.0 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Kelch_4 PF13418.1 ESA22536.1 - 1.9e-08 33.9 13.2 0.00084 19.0 0.3 4.6 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA22536.1 - 8.6e-08 32.0 3.5 0.0012 18.9 0.1 4.2 3 2 1 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA22536.1 - 1.2e-06 28.0 0.8 0.064 13.0 0.0 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.1 ESA22536.1 - 6e-06 26.2 3.4 0.003 17.6 0.0 3.9 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA22536.1 - 0.0094 15.4 0.2 0.0094 15.4 0.1 3.9 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 ESA22536.1 - 0.045 13.7 0.1 2.3 8.2 0.1 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.1 ESA22537.1 - 0.0013 18.8 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA22537.1 - 0.0063 16.2 0.0 0.039 13.7 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA22537.1 - 0.094 12.2 1.8 1.5 8.4 0.0 3.1 4 0 0 4 4 4 0 Kelch motif Tropomyosin_1 PF12718.2 ESA22538.1 - 0.053 13.3 10.1 0.11 12.3 6.3 2.0 1 1 0 1 1 1 0 Tropomyosin like Pox_A_type_inc PF04508.7 ESA22538.1 - 0.15 11.9 6.2 11 6.0 0.1 3.7 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Reo_sigmaC PF04582.7 ESA22538.1 - 5.4 6.1 6.8 7.3 5.6 4.7 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4407 PF14362.1 ESA22539.1 - 0.38 9.6 1.9 0.44 9.4 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C2H2 PF00096.21 ESA22540.1 - 0.00036 20.6 0.6 0.0012 19.0 0.4 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA22540.1 - 0.0009 19.3 0.7 0.0045 17.0 0.2 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 ESA22540.1 - 0.0045 17.1 0.3 0.017 15.2 0.2 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CENP-B_N PF04218.8 ESA22540.1 - 0.008 15.5 3.4 0.046 13.1 0.3 3.0 3 0 0 3 3 3 1 CENP-B N-terminal DNA-binding domain DUF1019 PF06254.6 ESA22540.1 - 0.018 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1019) DUF2481 PF10654.4 ESA22540.1 - 0.034 13.8 0.5 8.3 6.1 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2481) CRAL_TRIO_N PF03765.10 ESA22540.1 - 0.14 12.3 0.6 0.52 10.4 0.1 2.2 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain LRR_6 PF13516.1 ESA22544.1 - 7.8e-09 34.7 5.5 3.4 8.0 0.1 7.9 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.2 ESA22544.1 - 4.3e-07 29.3 3.9 0.067 12.8 0.2 5.5 4 2 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA22544.1 - 0.00096 18.8 7.0 1.6 8.5 0.2 4.9 4 1 1 5 5 5 2 Leucine rich repeat LRR_7 PF13504.1 ESA22544.1 - 0.0014 18.4 2.5 70 4.3 0.0 5.6 5 0 0 5 5 5 0 Leucine rich repeat DUF2889 PF11136.3 ESA22544.1 - 0.017 15.2 0.1 0.055 13.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2889) LRR_1 PF00560.28 ESA22544.1 - 2.5 8.4 8.8 65 4.1 0.1 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat Effector_1 PF04518.7 ESA22545.1 - 0.039 12.9 0.7 0.043 12.7 0.5 1.2 1 0 0 1 1 1 0 Effector from type III secretion system CBP4 PF07960.6 ESA22545.1 - 0.053 13.1 0.6 0.053 13.1 0.4 1.9 2 0 0 2 2 2 0 CBP4 DUF4200 PF13863.1 ESA22545.1 - 0.055 13.4 4.8 0.075 12.9 3.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) RBM1CTR PF08081.6 ESA22545.1 - 3.3 7.5 7.3 0.77 9.5 2.6 1.6 2 0 0 2 2 2 0 RBM1CTR (NUC064) family DUF3552 PF12072.3 ESA22545.1 - 6.6 5.8 10.2 1.4 8.0 2.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF4511 PF14974.1 ESA22546.1 - 0.063 13.0 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4511) DUF2972 PF11186.3 ESA22546.1 - 0.1 12.4 0.8 0.18 11.7 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2972) Methyltransf_14 PF08484.6 ESA22548.1 - 0.066 12.7 0.0 0.085 12.4 0.0 1.1 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain HTH_Tnp_Tc5 PF03221.11 ESA22549.1 - 0.025 14.4 0.0 0.056 13.2 0.0 1.6 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain BrkDBD PF09607.5 ESA22549.1 - 0.09 12.3 0.2 0.19 11.3 0.1 1.5 1 1 0 1 1 1 0 Brinker DNA-binding domain GAD PF02938.9 ESA22549.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 GAD domain Pkinase_Tyr PF07714.12 ESA22552.1 - 1.7e-31 109.2 0.0 1.9e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22552.1 - 5.6e-24 84.6 0.0 6.8e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain 4HBT PF03061.17 ESA22552.1 - 0.073 13.2 1.1 2.4 8.3 0.0 2.3 2 0 0 2 2 2 0 Thioesterase superfamily YtpI PF14007.1 ESA22553.1 - 2.6 8.0 7.3 0.27 11.1 0.8 2.0 1 1 1 2 2 2 0 YtpI-like protein Pkinase_Tyr PF07714.12 ESA22554.1 - 3.3e-35 121.4 0.0 4.5e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22554.1 - 2.3e-25 89.2 0.0 3e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-B_box PF00643.19 ESA22554.1 - 0.13 12.2 2.0 0.35 10.8 1.4 1.7 1 0 0 1 1 1 0 B-box zinc finger Pkinase_Tyr PF07714.12 ESA22555.1 - 1.6e-25 89.6 0.0 1.9e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22555.1 - 8e-22 77.6 0.0 9.8e-22 77.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WaaY PF06176.6 ESA22555.1 - 0.17 11.0 0.1 0.24 10.5 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA22556.1 - 7.5e-52 175.9 0.0 1e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22556.1 - 5.8e-48 163.3 0.3 9.9e-48 162.5 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA22556.1 - 5.6e-23 80.8 7.3 1.6e-11 44.4 1.0 2.7 2 0 0 2 2 2 2 Sel1 repeat Kdo PF06293.9 ESA22556.1 - 0.0006 18.9 0.1 0.0013 17.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_17 PF13431.1 ESA22556.1 - 0.0051 16.9 1.9 1.3 9.3 0.5 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat RIO1 PF01163.17 ESA22556.1 - 0.04 13.2 1.8 0.065 12.5 0.3 1.9 2 0 0 2 2 2 0 RIO1 family MIT PF04212.13 ESA22556.1 - 0.054 13.3 4.8 2.3 8.1 0.2 2.7 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA22556.1 - 0.062 13.2 4.6 0.2 11.5 3.2 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat APH PF01636.18 ESA22556.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_6 PF13174.1 ESA22556.1 - 0.2 12.2 2.8 1.3 9.6 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat HORMA PF02301.13 ESA22558.1 - 0.085 12.3 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 HORMA domain Kelch_3 PF13415.1 ESA22559.1 - 2.6e-16 59.2 1.6 5.1e-07 29.6 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_4 PF13418.1 ESA22559.1 - 5.9e-14 51.5 11.4 2.8e-05 23.7 0.0 5.3 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA22559.1 - 2.4e-12 46.4 7.5 0.0012 18.9 0.2 4.9 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.1 ESA22559.1 - 4.7e-09 36.0 0.4 0.012 15.5 0.2 4.5 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 ESA22559.1 - 8e-08 31.7 1.1 0.015 15.0 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA22559.1 - 6.2e-06 25.6 13.0 0.011 15.2 1.5 4.9 5 1 0 5 5 5 3 Kelch motif ETRAMP PF09716.5 ESA22559.1 - 0.0071 16.2 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) MCR_alpha_N PF02745.10 ESA22559.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, N-terminal domain Kelch_4 PF13418.1 ESA22560.1 - 0.00014 21.5 1.1 0.00065 19.4 0.0 2.7 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA22560.1 - 0.0016 18.5 1.8 0.11 12.7 0.0 3.3 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.10 ESA22560.1 - 0.04 13.7 0.1 1.3 8.9 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Borealin PF10512.4 ESA22560.1 - 0.046 13.6 0.2 0.076 12.9 0.1 1.3 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 OEP PF02321.13 ESA22560.1 - 0.38 10.3 1.7 8 6.0 0.1 2.1 2 0 0 2 2 2 0 Outer membrane efflux protein Kelch_4 PF13418.1 ESA22561.1 - 1.4e-11 43.9 7.0 0.0027 17.4 0.0 5.2 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA22561.1 - 9.2e-10 38.2 4.6 0.028 14.5 0.1 5.3 4 1 1 5 5 5 3 Kelch motif Kelch_3 PF13415.1 ESA22561.1 - 1.7e-08 34.4 1.3 0.046 13.8 0.0 4.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA22561.1 - 3.3e-06 26.6 0.0 0.27 11.0 0.0 4.9 4 2 1 5 5 5 2 Kelch motif Kelch_1 PF01344.20 ESA22561.1 - 0.0075 15.7 8.7 0.86 9.1 0.0 5.5 6 1 0 6 6 6 1 Kelch motif MULE PF10551.4 ESA22562.1 - 0.036 14.2 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 MULE transposase domain DUF600 PF04634.7 ESA22563.1 - 0.025 14.5 1.0 0.03 14.3 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF600 DUF1386 PF07138.6 ESA22563.1 - 0.091 11.8 0.1 0.8 8.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1386) ATG22 PF11700.3 ESA22564.1 - 1.8e-117 392.7 22.4 2e-117 392.5 15.5 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 ESA22564.1 - 4.7e-10 38.7 28.7 1.4e-05 23.9 14.7 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Pkinase PF00069.20 ESA22565.1 - 5.3e-23 81.4 4.0 1.9e-22 79.7 2.7 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22565.1 - 9.8e-22 77.2 0.0 3.1e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA22565.1 - 0.085 12.5 0.6 0.13 11.9 0.4 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tnp_zf-ribbon_2 PF13842.1 ESA22565.1 - 6.1 7.3 12.1 0.098 13.0 2.7 2.2 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Reeler PF02014.11 ESA22567.1 - 9.5e-07 29.1 0.1 1.8e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Reeler domain DUF1408 PF07193.6 ESA22568.1 - 0.0063 16.0 1.0 6.1 6.4 0.0 3.5 2 2 2 4 4 4 2 Protein of unknown function (DUF1408) DUF3828 PF12883.2 ESA22568.1 - 0.029 14.2 0.9 1.5 8.7 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3828) RRN7 PF11781.3 ESA22571.1 - 0.17 11.4 0.4 0.47 10.0 0.1 1.8 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 FolB PF02152.13 ESA22572.1 - 0.047 13.8 0.1 0.076 13.1 0.0 1.5 1 1 0 1 1 1 0 Dihydroneopterin aldolase Sel1 PF08238.7 ESA22575.1 - 1.7e-46 155.6 12.5 5.3e-11 42.7 0.1 5.2 5 0 0 5 5 5 5 Sel1 repeat MIT PF04212.13 ESA22575.1 - 0.0065 16.3 9.1 8.2 6.3 0.3 4.5 3 1 1 4 4 4 3 MIT (microtubule interacting and transport) domain NSF PF02071.15 ESA22575.1 - 0.19 12.4 5.6 48 5.2 0.0 4.8 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_11 PF13414.1 ESA22575.1 - 4.1 7.1 16.6 1.6 8.4 1.8 4.2 1 1 4 5 5 5 0 TPR repeat Sel1 PF08238.7 ESA22576.1 - 3.8e-47 157.6 23.2 2.9e-12 46.7 0.9 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.1 ESA22576.1 - 0.0058 17.0 10.4 3.7 8.2 0.5 5.9 6 1 0 6 6 6 1 Tetratricopeptide repeat Toprim_N PF08275.6 ESA22576.1 - 0.082 12.8 0.5 0.082 12.8 0.4 2.4 2 1 1 3 3 3 0 DNA primase catalytic core, N-terminal domain TPR_16 PF13432.1 ESA22576.1 - 0.12 13.0 6.4 1.4 9.6 0.7 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22576.1 - 8.8 6.3 13.4 21 5.1 0.0 4.6 4 2 0 4 4 4 0 Tetratricopeptide repeat TLD PF07534.11 ESA22577.1 - 9.4e-08 32.1 0.1 9.4e-08 32.1 0.1 1.8 3 0 0 3 3 3 1 TLD BTB PF00651.26 ESA22578.1 - 1.2e-17 63.9 0.0 2.5e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22578.1 - 1.5e-09 37.6 6.0 1.7e-07 31.0 0.6 3.1 1 1 2 3 3 3 2 BTB And C-terminal Kelch TLD PF07534.11 ESA22579.1 - 5.7e-10 39.3 0.2 1.2e-09 38.3 0.1 1.5 1 0 0 1 1 1 1 TLD SART-1 PF03343.8 ESA22583.1 - 0.056 11.7 0.1 0.06 11.6 0.1 1.1 1 0 0 1 1 1 0 SART-1 family DDE_1 PF03184.14 ESA22584.1 - 2.2e-08 33.5 0.3 2.4e-08 33.3 0.2 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Pkinase PF00069.20 ESA22586.1 - 5.2e-76 255.2 0.0 7.4e-76 254.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22586.1 - 1.2e-40 139.2 0.0 1.6e-40 138.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.14 ESA22586.1 - 8.4e-19 66.7 0.1 1.5e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.1 ESA22586.1 - 6.2e-06 25.3 0.0 1.9e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA22586.1 - 7.4e-05 21.9 0.1 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA22586.1 - 0.0034 17.1 0.0 0.021 14.5 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA22586.1 - 0.007 15.6 0.4 0.014 14.6 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA22586.1 - 0.038 13.3 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 ESA22586.1 - 0.099 11.9 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family LRR_4 PF12799.2 ESA22587.1 - 6.7e-17 60.7 9.1 3e-08 33.0 2.3 2.6 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA22587.1 - 4.1e-09 36.0 11.1 1.9e-08 33.9 3.3 2.7 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 ESA22587.1 - 5.6e-06 25.6 8.5 0.98 9.7 0.6 4.5 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_9 PF14580.1 ESA22587.1 - 1.7e-05 24.4 1.0 0.00049 19.7 0.1 2.1 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.1 ESA22587.1 - 5.3e-05 22.8 12.4 0.49 10.6 0.8 5.1 4 1 1 5 5 5 2 Leucine Rich repeat LRR_7 PF13504.1 ESA22587.1 - 0.00016 21.3 12.3 1.1 9.7 0.6 5.3 4 1 1 5 5 5 2 Leucine rich repeat PH PF00169.24 ESA22589.1 - 2.2e-05 24.5 0.3 2.2e-05 24.5 0.2 2.6 3 0 0 3 3 3 1 PH domain Proteasome_A_N PF10584.4 ESA22589.1 - 0.092 12.0 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature Sel1 PF08238.7 ESA22590.1 - 1.3e-39 133.7 9.1 5.7e-10 39.4 0.0 5.7 5 1 1 6 6 6 4 Sel1 repeat TPR_12 PF13424.1 ESA22590.1 - 0.003 17.4 8.4 0.086 12.7 0.7 3.9 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22590.1 - 0.013 15.1 12.1 0.048 13.3 0.1 4.4 4 1 1 5 5 5 0 TPR repeat TPR_6 PF13174.1 ESA22590.1 - 0.027 14.9 0.5 0.7 10.4 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.15 ESA22590.1 - 0.1 13.1 6.8 69 4.7 0.1 5.2 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.13 ESA22590.1 - 0.34 10.8 11.7 0.25 11.2 0.5 3.9 4 2 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 ESA22590.1 - 2.9 8.0 14.6 39 4.5 0.0 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat BTB PF00651.26 ESA22592.1 - 7.3e-19 67.8 0.1 1.3e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22592.1 - 4.6e-15 55.8 0.9 4.6e-15 55.8 0.6 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22592.1 - 1.6e-05 24.6 3.2 0.00011 21.9 0.3 3.5 3 1 0 3 3 3 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA22592.1 - 0.03 13.4 0.1 0.053 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Dehyd-heme_bind PF09098.5 ESA22592.1 - 0.082 12.3 0.0 0.72 9.2 0.0 2.0 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding PDDEXK_1 PF12705.2 ESA22593.1 - 5.7e-08 32.4 0.3 1.1e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.12 ESA22593.1 - 1.5e-05 24.9 2.4 4.6e-05 23.3 0.0 2.9 2 1 1 3 3 3 1 Domain of unknown function DUF83 AAA_11 PF13086.1 ESA22593.1 - 3.9e-05 23.3 2.3 0.00014 21.5 0.0 2.9 2 2 1 3 3 3 1 AAA domain Ribosomal_L29e PF01779.12 ESA22593.1 - 0.00031 20.5 0.3 0.00091 19.0 0.2 1.8 1 0 0 1 1 1 1 Ribosomal L29e protein family AAA_19 PF13245.1 ESA22593.1 - 0.0064 16.2 0.0 0.016 14.9 0.0 1.6 1 1 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 ESA22593.1 - 0.012 15.1 0.0 0.034 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 ESA22593.1 - 0.018 15.1 0.0 0.052 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA22593.1 - 0.21 10.4 0.0 6 5.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein PSP1 PF04468.7 ESA22595.1 - 0.039 13.9 2.2 0.14 12.1 0.0 2.9 4 0 0 4 4 4 0 PSP1 C-terminal conserved region ERK-JNK_inhib PF15002.1 ESA22596.1 - 0.0095 15.3 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor Gypsy PF07253.6 ESA22596.1 - 0.12 10.6 2.7 0.34 9.1 0.9 2.2 1 1 1 2 2 2 0 Gypsy protein Pkinase_Tyr PF07714.12 ESA22597.1 - 1.3e-18 67.0 0.0 8.4e-18 64.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22597.1 - 9.9e-13 47.8 0.6 2.9e-12 46.2 0.1 2.0 2 2 0 2 2 2 1 Protein kinase domain PTH2 PF01981.11 ESA22597.1 - 0.0031 17.1 0.0 0.024 14.3 0.0 2.1 2 0 0 2 2 2 1 Peptidyl-tRNA hydrolase PTH2 UPF0556 PF10572.4 ESA22597.1 - 0.082 12.0 0.3 0.14 11.3 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 Cytochrome_C7 PF14522.1 ESA22597.1 - 1.8 8.2 9.0 5.8 6.6 6.5 1.7 1 1 0 1 1 1 0 Cytochrome c7 zf-C3HC4_3 PF13920.1 ESA22597.1 - 2.2 7.9 8.0 0.13 11.9 0.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3624 PF12292.3 ESA22597.1 - 6.4 7.2 8.0 34 4.9 5.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3624) Pkinase PF00069.20 ESA22598.1 - 2.8e-59 200.3 0.1 3.2e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22598.1 - 5.8e-28 97.6 0.0 6.7e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA22598.1 - 2.5e-05 23.4 0.0 7e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 ESA22598.1 - 0.0023 17.0 0.0 0.0041 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 ESA22598.1 - 0.0037 16.6 0.1 0.0076 15.6 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Fip1 PF05182.8 ESA22598.1 - 0.027 13.7 0.2 0.059 12.6 0.1 1.6 1 0 0 1 1 1 0 Fip1 motif APG5 PF04106.7 ESA22598.1 - 0.061 12.7 0.1 0.096 12.1 0.1 1.4 1 0 0 1 1 1 0 Autophagy protein Apg5 Rtf2 PF04641.7 ESA22599.1 - 4.7e-07 29.2 7.4 5.9e-07 28.9 5.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_5 PF14634.1 ESA22599.1 - 3e-06 26.8 12.3 5.9e-06 25.9 8.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA22599.1 - 3.1e-06 27.1 14.8 5.3e-06 26.3 10.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA22599.1 - 2.3e-05 24.1 10.7 4.1e-05 23.3 7.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA22599.1 - 0.00011 21.7 15.9 0.00043 19.8 11.0 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UPF0547 PF10571.4 ESA22599.1 - 0.0017 18.0 1.3 0.0017 18.0 0.9 1.9 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 zf-C3HC4 PF00097.20 ESA22599.1 - 0.0046 16.5 14.0 0.01 15.4 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA22599.1 - 0.083 12.6 13.6 0.21 11.3 9.5 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 ESA22599.1 - 0.36 10.7 11.4 0.97 9.3 8.0 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 ESA22599.1 - 0.43 10.7 8.8 0.49 10.5 5.6 1.5 1 1 0 1 1 1 0 RING-H2 zinc finger zf-RING_4 PF14570.1 ESA22599.1 - 1.5 8.4 14.5 6.4 6.4 0.2 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 ESA22599.1 - 9.1 5.9 9.6 2.6 7.6 3.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Calreticulin PF00262.13 ESA22600.1 - 6.7e-113 377.0 13.8 6.7e-113 377.0 9.6 1.6 2 0 0 2 2 2 1 Calreticulin family eRF1_1 PF03463.10 ESA22600.1 - 0.013 15.0 0.2 0.036 13.6 0.1 1.7 1 0 0 1 1 1 0 eRF1 domain 1 Granulin PF00396.13 ESA22601.1 - 7.2 6.8 20.8 19 5.4 14.4 1.8 1 1 0 1 1 1 0 Granulin Inhibitor_I36 PF03995.8 ESA22602.1 - 0.054 13.8 0.7 0.11 12.8 0.4 1.6 1 1 1 2 2 2 0 Peptidase inhibitor family I36 SPRY PF00622.23 ESA22603.1 - 1.1e-19 70.6 0.1 1.5e-19 70.2 0.1 1.2 1 0 0 1 1 1 1 SPRY domain ROKNT PF08067.6 ESA22605.1 - 3.9 7.3 4.9 45 4.0 0.7 3.0 2 1 0 2 2 2 0 ROKNT (NUC014) domain PyrI_C PF02748.10 ESA22606.1 - 0.013 14.9 0.1 0.038 13.4 0.0 1.8 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain PurS PF02700.9 ESA22606.1 - 0.025 14.5 0.4 0.057 13.3 0.2 1.6 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase Dala_Dala_lig_C PF07478.8 ESA22606.1 - 0.036 13.4 0.1 0.056 12.8 0.1 1.3 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus zf-BED PF02892.10 ESA22606.1 - 0.11 12.3 0.2 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 BED zinc finger Aldo_ket_red PF00248.16 ESA22608.1 - 1.8e-31 109.0 0.0 8.7e-12 44.4 0.0 3.0 1 1 2 3 3 3 3 Aldo/keto reductase family Macoilin PF09726.4 ESA22609.1 - 0.057 11.7 16.4 0.068 11.4 11.4 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF605 PF04652.11 ESA22609.1 - 0.089 12.1 13.3 0.1 11.9 9.2 1.1 1 0 0 1 1 1 0 Vta1 like Hid1 PF12722.2 ESA22609.1 - 0.42 8.2 14.1 0.49 8.0 9.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gag_spuma PF03276.9 ESA22609.1 - 0.98 7.6 18.6 1.2 7.3 12.9 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Suf PF05843.9 ESA22609.1 - 1.1 8.8 8.5 1.5 8.5 5.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Peptidase_S64 PF08192.6 ESA22609.1 - 2.6 6.2 14.4 3 6.0 10.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Menin PF05053.8 ESA22609.1 - 3 5.9 10.5 3.4 5.7 7.3 1.1 1 0 0 1 1 1 0 Menin DNA_pol_viral_N PF00242.12 ESA22609.1 - 3.2 6.6 19.1 4 6.3 13.2 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Ndc1_Nup PF09531.5 ESA22609.1 - 3.5 5.9 14.1 4.1 5.6 9.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MIP-T3 PF10243.4 ESA22609.1 - 4.9 5.5 17.9 6.3 5.1 12.4 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 DUF4551 PF15087.1 ESA22609.1 - 6.1 5.0 14.1 7 4.8 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) R-HINP1I PF11463.3 ESA22611.1 - 0.0036 16.7 1.7 0.0048 16.3 1.1 1.2 1 0 0 1 1 1 1 R.HinP1I restriction endonuclease ING PF12998.2 ESA22611.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Stap_Strp_tox_C PF02876.12 ESA22611.1 - 0.019 15.1 0.7 0.16 12.1 0.3 2.1 1 1 1 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Dimer_Tnp_hAT PF05699.9 ESA22613.1 - 0.015 14.8 0.4 0.036 13.6 0.0 1.7 2 1 0 2 2 2 0 hAT family C-terminal dimerisation region Herpes_UL95 PF03038.9 ESA22613.1 - 0.054 12.3 0.0 0.061 12.2 0.0 1.1 1 0 0 1 1 1 0 UL95 family HTH_21 PF13276.1 ESA22613.1 - 0.066 13.2 0.0 0.14 12.1 0.0 1.7 1 1 0 1 1 1 0 HTH-like domain E1_DerP2_DerF2 PF02221.10 ESA22614.1 - 4.3e-07 30.2 0.0 5.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 ML domain Sipho_tail PF05709.6 ESA22615.1 - 0.012 14.7 1.3 0.013 14.6 0.9 1.1 1 0 0 1 1 1 0 Phage tail protein HTH_44 PF14641.1 ESA22615.1 - 0.012 15.5 0.6 0.016 15.1 0.4 1.1 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 ArsC PF03960.10 ESA22615.1 - 0.026 14.5 0.4 0.065 13.3 0.2 1.6 1 1 0 1 1 1 0 ArsC family PIG-H PF10181.4 ESA22615.1 - 0.057 13.0 0.2 0.093 12.3 0.2 1.4 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component DDE_1 PF03184.14 ESA22616.1 - 2.4e-07 30.1 0.0 2.8e-07 29.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease FAD_binding_3 PF01494.14 ESA22617.1 - 1.8e-15 56.8 0.0 1.8e-08 33.8 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 ESA22617.1 - 7.7e-05 22.6 0.0 0.00039 20.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 ESA22617.1 - 0.00015 21.5 0.0 0.00044 20.0 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA22617.1 - 0.00085 19.4 0.0 0.0018 18.3 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Sel1 PF08238.7 ESA22618.1 - 6.5e-51 169.6 18.0 1.8e-09 37.9 0.1 6.2 6 0 0 6 6 6 5 Sel1 repeat MIT PF04212.13 ESA22618.1 - 2.6e-05 24.0 20.5 1.2 9.0 0.5 5.2 3 1 1 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 ESA22618.1 - 0.00077 19.3 12.9 0.0029 17.5 0.9 3.7 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22618.1 - 0.0013 18.3 18.8 0.043 13.4 1.5 3.7 2 1 2 4 4 4 4 TPR repeat Surfac_D-trimer PF09006.6 ESA22618.1 - 0.0034 17.0 4.8 26 4.6 0.0 5.0 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation MA3 PF02847.12 ESA22618.1 - 0.011 15.4 0.8 0.035 13.8 0.1 2.3 2 1 1 3 3 3 0 MA3 domain HTH_16 PF12645.2 ESA22618.1 - 0.028 14.3 3.2 5.6 6.9 0.1 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain TPR_6 PF13174.1 ESA22618.1 - 0.062 13.7 6.0 7.4 7.2 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat B2-adapt-app_C PF09066.5 ESA22618.1 - 0.094 12.5 4.9 0.99 9.2 0.2 3.4 2 2 2 4 4 4 0 Beta2-adaptin appendage, C-terminal sub-domain DUF4600 PF15372.1 ESA22618.1 - 0.095 12.9 2.1 1.7 8.9 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4600) DCP1 PF06058.8 ESA22618.1 - 0.15 12.0 2.7 7.9 6.5 0.0 3.7 3 2 1 4 4 4 0 Dcp1-like decapping family TPR_2 PF07719.12 ESA22618.1 - 1.3 9.1 23.8 3.3 7.8 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat MKT1_C PF12246.3 ESA22618.1 - 2.7 6.9 8.2 3 6.7 0.3 2.8 1 1 1 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication BssC_TutF PF08201.6 ESA22618.1 - 7.4 6.1 13.0 4.7 6.7 0.1 4.0 4 0 0 4 4 4 0 BssC/TutF protein MRP-L46 PF11788.3 ESA22618.1 - 8 7.1 14.0 36 5.0 0.2 4.5 4 1 1 5 5 5 0 39S mitochondrial ribosomal protein L46 TPR_1 PF00515.23 ESA22618.1 - 8.5 6.1 24.0 3.1 7.5 0.1 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA22618.1 - 9.4 6.6 8.5 20 5.6 0.4 3.9 3 1 2 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.7 ESA22619.1 - 1.5e-48 162.1 17.6 2.3e-09 37.5 0.1 6.1 6 0 0 6 6 6 6 Sel1 repeat gp45-slide_C PF09116.5 ESA22619.1 - 0.12 12.3 0.7 0.29 11.1 0.0 1.9 2 0 0 2 2 2 0 gp45 sliding clamp, C terminal DUF2235 PF09994.4 ESA22619.1 - 0.68 9.2 3.5 2.5 7.3 0.1 2.7 1 1 2 3 3 3 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) TPR_6 PF13174.1 ESA22619.1 - 0.84 10.2 6.8 9.5 6.9 0.0 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat P-mevalo_kinase PF04275.9 ESA22620.1 - 0.033 13.8 3.8 2.1 8.1 0.2 2.1 1 1 1 2 2 2 0 Phosphomevalonate kinase SAD_SRA PF02182.12 ESA22623.1 - 7.7e-48 161.7 0.0 1.8e-47 160.5 0.0 1.6 2 0 0 2 2 2 1 SAD/SRA domain ubiquitin PF00240.18 ESA22623.1 - 2.4e-15 55.6 0.1 2.4e-15 55.6 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin family PHD PF00628.24 ESA22623.1 - 9.6e-11 41.2 10.9 9.6e-11 41.2 7.5 4.2 4 0 0 4 4 4 1 PHD-finger zf-C3HC4 PF00097.20 ESA22623.1 - 3.1e-06 26.7 10.0 3.1e-06 26.7 7.0 3.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA22623.1 - 1.3e-05 25.0 10.9 1.3e-05 25.0 7.6 4.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA22623.1 - 1.6e-05 24.4 7.8 1.6e-05 24.4 5.4 3.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA22623.1 - 2.7e-05 23.9 10.4 2.7e-05 23.9 7.2 4.1 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 ESA22623.1 - 3.6e-05 23.2 1.5 3.6e-05 23.2 1.0 4.1 3 1 1 4 4 2 1 RING/Ubox like zinc-binding domain Rad60-SLD PF11976.3 ESA22623.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RING_5 PF14634.1 ESA22623.1 - 0.00029 20.5 9.5 0.00029 20.5 6.6 3.6 2 1 1 3 3 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESA22623.1 - 0.0057 16.4 10.1 0.0057 16.4 7.0 3.1 2 1 0 2 2 2 1 Ring finger domain TLD PF07534.11 ESA22624.1 - 1.1e-10 41.5 0.5 1.8e-10 40.9 0.4 1.4 1 1 0 1 1 1 1 TLD Seipin PF06775.9 ESA22626.1 - 1.7e-41 141.9 0.4 2.5e-41 141.4 0.3 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Ribosomal_S13 PF00416.17 ESA22627.1 - 2.2e-11 44.1 2.1 2.8e-11 43.8 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Myb_DNA-bind_6 PF13921.1 ESA22628.1 - 7.6e-08 32.3 0.3 1.9e-07 31.0 0.2 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 ESA22628.1 - 5e-07 29.6 0.2 5e-07 29.6 0.1 1.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Sel1 PF08238.7 ESA22629.1 - 3.3e-57 189.6 39.1 2.9e-09 37.2 0.7 9.1 9 0 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.1 ESA22629.1 - 0.069 13.6 28.1 2.4 8.7 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22629.1 - 0.11 12.3 15.4 1.3 9.0 0.1 5.5 3 2 2 5 5 5 0 Tetratricopeptide repeat PPR PF01535.15 ESA22629.1 - 9 6.5 9.2 12 6.1 0.1 4.3 5 0 0 5 5 5 0 PPR repeat BTB PF00651.26 ESA22630.1 - 4.5e-17 62.0 0.5 1.3e-16 60.5 0.4 1.8 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22630.1 - 2.5e-15 56.6 1.7 5.9e-15 55.4 1.2 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA22630.1 - 0.089 12.6 2.5 0.19 11.5 0.4 2.7 1 1 0 1 1 1 0 BTB And C-terminal Kelch F-box-like PF12937.2 ESA22631.1 - 1.3e-12 47.2 1.7 3.5e-12 45.8 1.2 1.9 1 1 0 1 1 1 1 F-box-like F-box PF00646.28 ESA22631.1 - 1.7e-07 30.7 0.2 1.7e-07 30.7 0.2 2.4 2 1 0 2 2 2 1 F-box domain PRANC PF09372.5 ESA22631.1 - 0.096 12.6 0.1 0.096 12.6 0.1 2.8 3 1 0 3 3 3 0 PRANC domain F-box-like PF12937.2 ESA22632.1 - 1.1e-06 28.2 0.4 2.2e-06 27.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA22632.1 - 1.2e-06 28.0 1.5 1.8e-06 27.4 0.2 2.0 2 0 0 2 2 2 1 F-box domain PRANC PF09372.5 ESA22632.1 - 0.035 14.0 1.3 0.11 12.4 0.9 1.9 1 0 0 1 1 1 0 PRANC domain F-box-like PF12937.2 ESA22633.1 - 0.00037 20.1 0.2 0.00096 18.8 0.1 1.8 1 0 0 1 1 1 1 F-box-like DUF4125 PF13526.1 ESA22633.1 - 0.018 14.5 0.1 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4125) RRM_1 PF00076.17 ESA22634.1 - 1.6e-05 24.4 0.0 3.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22634.1 - 0.0018 18.1 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Pkinase_Tyr PF07714.12 ESA22635.1 - 3.1e-08 33.0 0.0 3.9e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22635.1 - 0.00034 19.8 0.5 0.0004 19.6 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Glyco_hydro_17 PF00332.13 ESA22636.1 - 0.042 12.8 0.4 0.048 12.6 0.3 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 P34-Arc PF04045.9 ESA22639.1 - 0.018 14.3 0.4 0.02 14.1 0.3 1.1 1 0 0 1 1 1 0 Arp2/3 complex, 34 kD subunit p34-Arc Val_tRNA-synt_C PF10458.4 ESA22642.1 - 0.00095 19.2 2.4 0.0018 18.3 1.6 1.4 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm DUF3963 PF13124.1 ESA22642.1 - 0.0037 17.0 0.1 0.0083 15.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3963) G10 PF01125.12 ESA22642.1 - 0.0047 16.4 1.2 0.0085 15.6 0.9 1.4 1 0 0 1 1 1 1 G10 protein AAA_23 PF13476.1 ESA22642.1 - 0.088 13.1 8.8 0.11 12.8 6.1 1.1 1 0 0 1 1 1 0 AAA domain UPF0184 PF03670.8 ESA22642.1 - 0.089 12.9 0.5 0.17 12.0 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) FlxA PF14282.1 ESA22642.1 - 4.1 7.3 9.1 0.095 12.6 1.8 1.6 2 0 0 2 2 2 0 FlxA-like protein HTH_Tnp_Tc5 PF03221.11 ESA22643.1 - 2.7e-06 27.0 0.3 1.4e-05 24.7 0.0 2.2 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA22643.1 - 2.8e-05 23.3 0.1 0.0011 18.1 0.0 2.2 1 1 1 2 2 2 2 DDE superfamily endonuclease PRK PF00485.13 ESA22643.1 - 0.088 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Arrestin_N PF00339.24 ESA22644.1 - 1e-10 41.5 0.0 1.5e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain UCH_1 PF13423.1 ESA22644.1 - 0.053 12.9 0.0 0.066 12.6 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Pkinase_Tyr PF07714.12 ESA22645.1 - 1.6e-41 142.0 0.0 2.5e-41 141.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22645.1 - 3.8e-40 137.6 0.0 5.9e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22646.1 - 2.5e-29 102.1 0.1 3.3e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22646.1 - 1.1e-25 90.2 0.2 2.9e-25 88.9 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain EAP30 PF04157.11 ESA22646.1 - 0.091 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Kri1 PF05178.7 ESA22647.1 - 1.3e-29 102.3 14.2 1.3e-29 102.3 9.8 5.4 6 2 0 6 6 6 1 KRI1-like family Kri1_C PF12936.2 ESA22647.1 - 2.6e-27 94.6 2.6 2.6e-27 94.6 1.8 4.2 2 1 1 3 3 3 1 KRI1-like family C-terminal zf-ZPR1 PF03367.8 ESA22647.1 - 1.7 7.7 5.5 0.38 9.9 0.7 2.2 2 0 0 2 2 2 0 ZPR1 zinc-finger domain NEP PF10167.4 ESA22648.1 - 1.2e-19 70.1 1.3 1.3e-19 70.0 0.9 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein Syntaxin-6_N PF09177.6 ESA22648.1 - 0.039 14.3 0.1 0.069 13.5 0.1 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Spore_III_AB PF09548.5 ESA22648.1 - 0.045 13.5 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Peptidase_M50B PF13398.1 ESA22649.1 - 1.8e-55 187.4 11.6 2.3e-55 187.0 8.0 1.1 1 0 0 1 1 1 1 Peptidase M50B-like DUF373 PF04123.8 ESA22649.1 - 2.1 7.2 6.2 0.25 10.3 1.4 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF373) Gpi1 PF05024.10 ESA22650.1 - 9.1e-62 208.1 10.1 9.1e-62 208.1 7.0 2.0 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) HSP20 PF00011.16 ESA22651.1 - 3.1e-18 65.4 0.2 1.9e-17 62.9 0.1 1.8 1 1 0 1 1 1 1 Hsp20/alpha crystallin family F-box-like PF12937.2 ESA22652.1 - 0.0016 18.1 0.4 0.0016 18.1 0.3 2.1 2 0 0 2 2 2 1 F-box-like DUF2806 PF10987.3 ESA22652.1 - 0.14 11.5 7.3 0.33 10.4 5.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2806) F-box-like PF12937.2 ESA22653.1 - 1.8e-05 24.3 0.1 4.6e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.2 ESA22655.1 - 0.031 14.0 0.6 0.1 12.3 0.1 2.1 2 0 0 2 2 2 0 F-box-like Dimer_Tnp_hAT PF05699.9 ESA22656.1 - 9.1e-16 57.2 0.0 9.8e-16 57.1 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region BCS1_N PF08740.6 ESA22660.1 - 1.5e-05 24.6 0.0 0.3 10.6 0.0 3.4 3 0 0 3 3 3 2 BCS1 N terminal Syd PF07348.7 ESA22660.1 - 0.0087 15.4 6.4 0.077 12.3 0.0 3.2 4 0 0 4 4 4 2 Syd protein (SUKH-2) Cas_Cmr5 PF09701.5 ESA22660.1 - 0.015 15.4 3.9 1.6 8.9 0.2 3.5 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cmr5) RICH PF05062.7 ESA22660.1 - 1.2 9.2 10.7 1.6 8.9 0.3 3.4 3 0 0 3 3 3 0 RICH domain DUF190 PF02641.10 ESA22660.1 - 1.3 8.9 7.0 38 4.2 0.1 4.7 4 2 2 6 6 6 0 Uncharacterized ACR, COG1993 BCS1_N PF08740.6 ESA22663.1 - 4.9e-07 29.5 0.1 1.2 8.7 0.0 5.0 6 0 0 6 6 6 3 BCS1 N terminal DUF4116 PF13475.1 ESA22663.1 - 0.00031 20.1 10.7 17 4.9 0.0 6.4 5 0 0 5 5 5 4 Domain of unknown function (DUF4116) Spore_III_AB PF09548.5 ESA22663.1 - 0.0029 17.3 0.1 13 5.4 0.0 4.6 5 0 0 5 5 5 2 Stage III sporulation protein AB (spore_III_AB) YuzL PF14115.1 ESA22663.1 - 0.01 16.0 1.1 34 4.8 0.0 4.9 5 0 0 5 5 5 0 YuzL-like protein Pkinase_Tyr PF07714.12 ESA22665.1 - 4.8e-37 127.4 0.0 6.8e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22665.1 - 2.6e-35 121.8 0.0 4.2e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA22665.1 - 0.037 13.1 0.0 0.066 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BCS1_N PF08740.6 ESA22666.1 - 9.6e-10 38.3 0.9 0.073 12.6 0.0 3.9 4 0 0 4 4 4 3 BCS1 N terminal Frataxin_Cyay PF01491.11 ESA22666.1 - 0.011 15.5 13.2 0.28 10.9 0.0 5.4 4 2 1 5 5 5 0 Frataxin-like domain zf-ribbon_3 PF13248.1 ESA22666.1 - 0.023 13.9 1.3 0.023 13.9 0.9 3.8 3 0 0 3 3 3 0 zinc-ribbon domain RCC1_2 PF13540.1 ESA22667.1 - 0.032 13.8 0.1 0.051 13.2 0.1 1.2 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat zf-CCHC_5 PF14787.1 ESA22668.1 - 0.11 11.9 0.4 4.3 6.9 0.0 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC PF00098.18 ESA22668.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.0 2 0 0 2 2 2 0 Zinc knuckle FBD PF08387.5 ESA22669.1 - 0.052 13.0 0.8 1.9 8.0 0.1 2.7 2 0 0 2 2 2 0 FBD Imm8 PF15560.1 ESA22669.1 - 0.078 12.6 4.2 0.11 12.1 1.9 2.2 1 1 0 1 1 1 0 Immunity protein 8 Sel1 PF08238.7 ESA22670.1 - 3.6e-86 281.6 47.3 8.2e-13 48.5 0.8 9.3 9 0 0 9 9 9 9 Sel1 repeat TPR_20 PF14561.1 ESA22670.1 - 2.6e-08 33.8 3.3 0.24 11.5 0.0 6.2 1 1 4 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22670.1 - 3.1e-07 30.4 22.4 0.15 12.5 0.2 8.4 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22670.1 - 2e-05 24.4 17.1 6.2 7.2 0.1 8.7 8 1 1 9 9 9 1 Tetratricopeptide repeat Surfac_D-trimer PF09006.6 ESA22670.1 - 4.3e-05 23.1 8.4 3.9 7.2 0.1 5.7 5 0 0 5 5 5 1 Lung surfactant protein D coiled-coil trimerisation Peptidase_C14 PF00656.17 ESA22670.1 - 0.00021 21.0 0.0 0.65 9.6 0.0 4.2 1 1 1 3 3 3 1 Caspase domain MIT PF04212.13 ESA22670.1 - 0.0086 15.9 22.0 3 7.7 0.4 6.1 6 1 0 6 6 6 1 MIT (microtubule interacting and transport) domain Foie-gras_1 PF11817.3 ESA22670.1 - 0.029 13.8 9.4 0.097 12.1 1.2 3.4 1 1 2 3 3 3 0 Foie gras liver health family 1 Phage_tail_2 PF06199.6 ESA22670.1 - 0.051 13.6 0.4 16 5.5 0.0 3.0 2 1 1 3 3 3 0 Phage major tail protein 2 EcoRI PF02963.11 ESA22670.1 - 0.065 12.0 1.1 14 4.3 0.0 4.3 1 1 3 5 5 5 0 Restriction endonuclease EcoRI TPR_19 PF14559.1 ESA22670.1 - 0.14 12.5 7.5 1.1 9.6 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 ESA22670.1 - 0.17 12.6 5.3 5.4 7.8 0.1 4.8 4 3 2 6 6 5 0 Tetratricopeptide repeat RE_CfrBI PF09516.5 ESA22670.1 - 0.17 10.7 6.1 0.078 11.8 0.5 2.9 1 1 1 2 2 2 0 CfrBI restriction endonuclease Prenyltrans_1 PF13243.1 ESA22670.1 - 0.25 11.3 6.9 5.8 6.9 0.1 4.4 2 2 0 3 3 3 0 Prenyltransferase-like DUF3830 PF12903.2 ESA22670.1 - 1 8.7 4.0 89 2.4 0.2 4.2 3 2 2 5 5 5 0 Protein of unknown function (DUF3830) HTH_16 PF12645.2 ESA22670.1 - 3.1 7.8 14.0 16 5.4 0.0 6.2 8 1 1 9 9 7 0 Helix-turn-helix domain B2-adapt-app_C PF09066.5 ESA22670.1 - 8.5 6.2 12.8 9.1 6.1 0.1 5.3 2 1 5 7 7 7 0 Beta2-adaptin appendage, C-terminal sub-domain DUF1639 PF07797.9 ESA22671.1 - 0.024 14.0 3.1 0.13 11.6 2.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1639) Lipase_bact_N PF12262.3 ESA22672.1 - 0.019 14.1 0.0 0.019 14.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial virulence factor lipase N-terminal T4_gp9_10 PF07880.6 ESA22672.1 - 0.062 12.3 0.2 0.098 11.7 0.1 1.4 1 1 0 1 1 1 0 Bacteriophage T4 gp9/10-like protein Pkinase_Tyr PF07714.12 ESA22673.1 - 0.0021 17.1 0.0 0.0031 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22673.1 - 0.066 12.3 0.0 0.15 11.1 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain RNase_H PF00075.19 ESA22674.1 - 0.00013 22.2 0.0 0.00015 22.0 0.0 1.2 1 0 0 1 1 1 1 RNase H GTP_EFTU PF00009.22 ESA22676.1 - 2.7e-49 167.1 0.0 3.9e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 ESA22676.1 - 1.2e-10 41.4 0.1 3.3e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.18 ESA22676.1 - 5.5e-08 32.7 0.0 9.7e-07 28.7 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 ESA22676.1 - 6.3e-08 32.6 0.4 1.5e-07 31.4 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 ESA22676.1 - 2.6e-06 27.9 0.1 0.00035 21.0 0.0 2.5 1 1 0 1 1 1 1 Miro-like protein GTP_EFTU_D4 PF14578.1 ESA22676.1 - 0.00073 19.1 1.7 0.0011 18.4 0.4 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Ras PF00071.17 ESA22676.1 - 0.0094 15.3 0.1 0.17 11.2 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_22 PF13401.1 ESA22676.1 - 0.014 15.5 0.0 0.036 14.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.5 ESA22676.1 - 0.018 14.2 0.0 0.39 9.9 0.0 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.14 ESA22676.1 - 0.032 13.6 0.1 5.4 6.4 0.0 2.6 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 ESA22676.1 - 0.038 13.7 0.4 0.64 9.8 0.0 2.7 2 1 1 3 3 3 0 Dynamin family Septin PF00735.13 ESA22676.1 - 0.075 12.0 0.0 0.14 11.1 0.0 1.4 1 1 0 1 1 1 0 Septin HBS1_N PF08938.5 ESA22677.1 - 5.7e-13 48.7 6.7 7.5e-13 48.4 4.7 1.2 1 0 0 1 1 1 1 HBS1 N-terminus Inhibitor_I53 PF11714.3 ESA22677.1 - 0.016 15.1 1.2 0.026 14.5 0.9 1.4 1 0 0 1 1 1 0 Thrombin inhibitor Madanin ResIII PF04851.10 ESA22677.1 - 0.023 14.5 0.4 0.027 14.2 0.3 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PBP1_TM PF14812.1 ESA22677.1 - 0.096 13.0 3.2 0.29 11.4 1.1 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GRIN_C PF15235.1 ESA22678.1 - 0.97 9.5 3.7 1.2 9.2 2.6 1.1 1 0 0 1 1 1 0 G protein-regulated inducer of neurite outgrowth C-terminus G0-G1_switch_2 PF15103.1 ESA22679.1 - 0.097 12.8 0.1 0.099 12.8 0.1 1.0 1 0 0 1 1 1 0 G0/G1 switch protein 2 SHR3_chaperone PF08229.6 ESA22679.1 - 0.13 11.1 0.2 0.16 10.9 0.1 1.1 1 0 0 1 1 1 0 ER membrane protein SH3 Laminin_II PF06009.7 ESA22680.1 - 0.00022 20.9 1.7 0.00057 19.6 1.2 1.8 1 0 0 1 1 1 1 Laminin Domain II EzrA PF06160.7 ESA22680.1 - 0.0017 16.6 4.5 0.0026 16.0 3.1 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF148 PF02520.12 ESA22680.1 - 0.015 15.0 0.2 0.24 11.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF148 Tropomyosin_1 PF12718.2 ESA22680.1 - 0.021 14.6 6.7 0.048 13.5 4.6 1.5 1 0 0 1 1 1 0 Tropomyosin like APG6 PF04111.7 ESA22680.1 - 0.025 13.6 6.1 0.044 12.8 4.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2392 PF10288.4 ESA22680.1 - 0.092 13.0 0.8 0.29 11.5 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) Voltage_CLC PF00654.15 ESA22681.1 - 2.8e-88 296.3 29.1 2.8e-88 296.3 20.2 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 ESA22681.1 - 3.6e-11 42.6 0.2 2.6e-06 27.1 0.0 2.5 2 0 0 2 2 2 2 CBS domain PriCT_2 PF08707.6 ESA22681.1 - 1.1 9.2 5.2 0.41 10.5 1.2 2.1 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) Peptidase_S9_N PF02897.10 ESA22682.1 - 2.7e-117 391.8 7.7 3.4e-117 391.5 5.3 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.16 ESA22682.1 - 9.9e-65 217.7 1.0 8.7e-64 214.6 0.0 2.7 3 0 0 3 3 3 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 ESA22682.1 - 0.0036 16.7 0.0 0.0062 16.0 0.0 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) SQS_PSY PF00494.14 ESA22683.1 - 2.9e-22 79.2 0.0 7.9e-21 74.5 0.0 2.1 1 1 0 1 1 1 1 Squalene/phytoene synthase RRM_1 PF00076.17 ESA22686.1 - 3.3e-30 103.5 0.0 1.6e-15 56.5 0.0 2.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22686.1 - 6.9e-23 80.4 0.0 2e-10 40.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA22686.1 - 2.5e-07 30.4 0.0 1.1e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA22686.1 - 0.014 15.2 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Limkain-b1 PF11608.3 ESA22686.1 - 0.021 14.5 0.0 0.067 12.9 0.0 1.9 1 0 0 1 1 1 0 Limkain b1 DUF676 PF05057.9 ESA22687.1 - 3.3e-07 29.8 0.0 5.7e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.6 ESA22687.1 - 6.8e-06 25.3 0.0 0.0025 16.9 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.2 ESA22687.1 - 3.5e-05 23.5 0.0 8.8e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 ESA22687.1 - 3.6e-05 23.7 0.0 6.3e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 ESA22687.1 - 0.00012 21.7 0.0 0.0003 20.4 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Lipase_3 PF01764.20 ESA22687.1 - 0.00082 18.9 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_2 PF02230.11 ESA22687.1 - 0.0011 18.4 0.0 3.9 6.8 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase DUF2974 PF11187.3 ESA22687.1 - 0.0019 17.6 0.0 0.005 16.2 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Thioesterase PF00975.15 ESA22687.1 - 0.0078 16.4 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.15 ESA22687.1 - 0.0078 15.7 0.1 0.016 14.7 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.7 ESA22687.1 - 0.014 14.7 0.0 0.53 9.5 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_3 PF07859.8 ESA22687.1 - 0.032 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold LCAT PF02450.10 ESA22687.1 - 0.034 13.1 0.0 0.11 11.3 0.0 1.7 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase UPF0227 PF05728.7 ESA22687.1 - 0.23 11.1 1.0 6.9 6.3 0.0 3.1 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0227) NIF PF03031.13 ESA22688.1 - 2.3e-14 53.3 0.9 4.2e-14 52.5 0.1 1.7 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase TraC_F_IV PF11130.3 ESA22688.1 - 0.023 14.1 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer TipAS PF07739.8 ESA22688.1 - 3.8 7.8 11.3 10 6.4 7.5 1.8 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain Condensation PF00668.15 ESA22688.1 - 7.6 5.2 9.6 0.34 9.7 1.1 2.0 2 0 0 2 2 2 0 Condensation domain DUF3336 PF11815.3 ESA22691.1 - 0.071 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) CHASE3 PF05227.8 ESA22692.1 - 0.0044 16.6 0.5 0.023 14.3 0.1 2.0 2 0 0 2 2 2 1 CHASE3 domain Borrelia_REV PF03978.8 ESA22692.1 - 0.018 14.7 4.5 0.025 14.3 3.1 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein DUF424 PF04242.8 ESA22692.1 - 0.088 12.8 0.6 0.22 11.6 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF424) 7TMR-HDED PF07697.6 ESA22692.1 - 0.18 11.5 4.5 0.05 13.3 0.8 1.6 2 0 0 2 2 2 0 7TM-HD extracellular DUF2935 PF11155.3 ESA22692.1 - 0.61 10.1 4.0 2 8.5 2.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) PRANC PF09372.5 ESA22692.1 - 1.3 9.0 10.8 0.27 11.2 2.1 2.7 1 1 2 3 3 3 0 PRANC domain DUF3568 PF12092.3 ESA22693.1 - 0.031 13.9 1.0 0.047 13.4 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3568) zf-CCHC PF00098.18 ESA22696.1 - 0.0011 18.7 1.5 0.0018 18.0 1.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.1 ESA22696.1 - 0.074 12.5 0.7 0.15 11.5 0.5 1.5 1 0 0 1 1 1 0 Zinc knuckle eIF3g PF12353.3 ESA22696.1 - 0.078 12.8 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G MULE PF10551.4 ESA22698.1 - 9.9e-07 28.8 0.2 7.9e-06 25.9 0.0 2.3 1 1 2 3 3 3 1 MULE transposase domain DUF1574 PF07611.6 ESA22698.1 - 0.012 14.5 0.7 0.014 14.2 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) Topoisom_I PF01028.15 ESA22698.1 - 0.056 12.5 0.8 0.071 12.1 0.5 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core Sec3_C PF09763.4 ESA22699.1 - 0.11 10.6 0.2 0.12 10.4 0.1 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF3562 PF12085.3 ESA22700.1 - 0.076 12.8 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3562) Pkinase_Tyr PF07714.12 ESA22703.1 - 6.6e-28 97.4 0.0 7.6e-28 97.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22703.1 - 2.6e-27 95.6 0.1 5.1e-27 94.6 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA22703.1 - 3.7e-05 22.8 0.0 4.4e-05 22.5 0.0 1.0 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA22703.1 - 0.0016 18.2 0.4 0.0037 17.0 0.3 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA22703.1 - 0.0026 17.1 0.1 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA22703.1 - 0.0034 16.4 0.0 0.0041 16.2 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA22703.1 - 0.029 13.5 0.1 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 ESA22703.1 - 0.12 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Laminin_II PF06009.7 ESA22705.1 - 0.00022 20.9 2.4 0.00027 20.7 0.2 2.1 2 1 0 2 2 2 1 Laminin Domain II GP41 PF00517.12 ESA22705.1 - 0.0004 20.0 2.3 0.00058 19.4 1.2 1.6 1 1 0 1 1 1 1 Retroviral envelope protein KLRAQ PF10205.4 ESA22705.1 - 0.0015 18.5 2.2 0.0048 16.9 0.2 2.3 2 1 0 2 2 2 1 Predicted coiled-coil domain-containing protein Kinetocho_Slk19 PF12709.2 ESA22705.1 - 0.0022 18.0 1.5 0.0022 18.0 1.0 2.7 4 0 0 4 4 2 1 Central kinetochore-associated DUF1192 PF06698.6 ESA22705.1 - 0.0034 17.1 1.9 0.065 13.0 0.2 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Not3 PF04065.10 ESA22705.1 - 0.0053 16.0 3.4 0.0057 15.9 1.9 1.5 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component DASH_Spc34 PF08657.5 ESA22705.1 - 0.0054 16.4 0.5 0.0054 16.4 0.4 1.9 2 0 0 2 2 2 1 DASH complex subunit Spc34 Tropomyosin PF00261.15 ESA22705.1 - 0.014 14.4 0.3 0.044 12.8 0.1 1.9 2 0 0 2 2 2 0 Tropomyosin HSBP1 PF06825.7 ESA22705.1 - 0.017 14.6 0.2 0.046 13.2 0.1 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 TSC22 PF01166.13 ESA22705.1 - 0.018 14.9 1.0 0.018 14.9 0.7 2.9 3 0 0 3 3 2 0 TSC-22/dip/bun family DUF3373 PF11853.3 ESA22705.1 - 0.021 13.3 0.2 0.024 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) SSXT PF05030.7 ESA22705.1 - 0.024 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 SSXT protein (N-terminal region) AAA_27 PF13514.1 ESA22705.1 - 0.025 12.2 0.0 0.034 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain DivIC PF04977.10 ESA22705.1 - 0.032 13.7 2.6 0.12 11.8 0.2 2.6 3 0 0 3 3 2 0 Septum formation initiator FliJ PF02050.11 ESA22705.1 - 0.034 14.1 0.0 0.076 13.0 0.0 1.7 1 0 0 1 1 1 0 Flagellar FliJ protein Glutaredoxin2_C PF04399.8 ESA22705.1 - 0.043 13.3 1.5 2 7.9 0.1 2.3 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain PspA_IM30 PF04012.7 ESA22705.1 - 0.043 13.1 0.9 0.35 10.1 0.1 2.2 1 1 1 2 2 2 0 PspA/IM30 family DUF4140 PF13600.1 ESA22705.1 - 0.046 14.1 0.2 0.27 11.6 0.0 2.2 3 0 0 3 3 2 0 N-terminal domain of unknown function (DUF4140) DUF948 PF06103.6 ESA22705.1 - 0.047 13.5 2.1 0.083 12.7 0.1 2.3 3 0 0 3 3 1 0 Bacterial protein of unknown function (DUF948) Striatin PF08232.7 ESA22705.1 - 0.079 13.2 1.1 0.23 11.7 0.1 2.2 2 1 0 3 3 2 0 Striatin family WD40_alt PF14077.1 ESA22705.1 - 0.084 12.5 0.9 6.9 6.3 0.3 2.8 2 0 0 2 2 2 0 Alternative WD40 repeat motif Lge1 PF11488.3 ESA22705.1 - 0.094 12.9 0.3 0.24 11.6 0.2 1.7 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 bZIP_1 PF00170.16 ESA22705.1 - 0.097 12.6 0.9 0.097 12.6 0.6 2.9 3 0 0 3 3 2 0 bZIP transcription factor Laminin_I PF06008.9 ESA22705.1 - 0.1 11.8 6.5 0.51 9.6 4.4 2.4 1 1 0 1 1 1 0 Laminin Domain I Cep57_MT_bd PF06657.8 ESA22705.1 - 0.11 12.4 4.6 5.9 6.9 0.1 2.9 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 bZIP_2 PF07716.10 ESA22705.1 - 0.12 12.2 5.0 0.13 12.0 0.8 2.5 2 0 0 2 2 2 0 Basic region leucine zipper CENP-F_leu_zip PF10473.4 ESA22705.1 - 0.13 12.1 0.3 0.13 12.1 0.2 2.5 3 0 0 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 ESA22705.1 - 0.14 12.4 7.0 0.072 13.4 1.4 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF972) NPV_P10 PF05531.7 ESA22705.1 - 0.23 11.7 1.4 0.75 10.0 0.6 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein AF0941-like PF14591.1 ESA22705.1 - 0.32 11.0 4.0 0.16 12.0 0.5 2.1 2 1 1 3 3 3 0 AF0941-like FlaC_arch PF05377.6 ESA22705.1 - 0.36 10.7 5.3 0.3 11.0 0.6 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF342 PF03961.8 ESA22705.1 - 0.49 8.7 3.5 0.82 8.0 2.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) BLOC1_2 PF10046.4 ESA22705.1 - 0.5 10.5 6.0 0.13 12.3 0.6 2.4 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin PF02996.12 ESA22705.1 - 0.6 9.7 5.4 0.41 10.3 0.9 2.6 3 0 0 3 3 3 0 Prefoldin subunit DUF848 PF05852.6 ESA22705.1 - 0.62 9.8 3.8 0.53 10.1 0.9 2.2 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) IncA PF04156.9 ESA22705.1 - 0.7 9.4 2.8 1.6 8.3 2.0 1.8 1 1 0 1 1 1 0 IncA protein Seryl_tRNA_N PF02403.17 ESA22705.1 - 0.82 9.7 7.6 0.64 10.0 0.1 3.4 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF904 PF06005.7 ESA22705.1 - 1.1 9.5 9.8 0.16 12.2 0.7 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF904) ORF6C PF10552.4 ESA22705.1 - 1.3 8.7 5.1 2.2 8.0 0.1 3.0 4 0 0 4 4 3 0 ORF6C domain TMF_TATA_bd PF12325.3 ESA22705.1 - 1.5 8.5 6.0 1.3 8.7 2.7 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Med9 PF07544.8 ESA22705.1 - 2.2 8.0 4.9 0.93 9.2 0.3 2.5 2 1 1 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4559 PF15112.1 ESA22705.1 - 2.2 7.3 9.4 0.078 12.1 1.7 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4559) PhoU PF01895.14 ESA22705.1 - 3.7 8.0 5.5 1.6 9.2 0.8 2.4 1 1 1 3 3 3 0 PhoU domain Jnk-SapK_ap_N PF09744.4 ESA22705.1 - 3.9 7.4 9.3 1.5 8.8 2.1 2.7 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF4200 PF13863.1 ESA22705.1 - 4.9 7.1 7.7 0.74 9.7 1.8 2.2 2 1 0 2 2 1 0 Domain of unknown function (DUF4200) Syntaxin_2 PF14523.1 ESA22705.1 - 6.7 6.8 7.3 2 8.5 0.4 2.8 2 2 1 3 3 3 0 Syntaxin-like protein NTP_transf_2 PF01909.18 ESA22708.1 - 1.9e-06 28.1 0.3 1.9e-06 28.1 0.2 2.3 2 0 0 2 2 2 1 Nucleotidyltransferase domain BTB PF00651.26 ESA22712.1 - 3.6e-13 49.4 0.0 8.9e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22712.1 - 0.0038 17.0 1.9 0.02 14.6 0.3 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch Acetyltransf_1 PF00583.19 ESA22713.1 - 1.4e-14 53.8 0.0 1.9e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA22713.1 - 8e-07 29.1 0.0 1.4e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA22713.1 - 1.3e-05 25.3 0.0 1.8e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA22713.1 - 4.6e-05 23.0 0.2 8.1e-05 22.2 0.1 1.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.1 ESA22713.1 - 0.0014 18.8 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 ESA22713.1 - 0.0015 18.1 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 ESA22713.1 - 0.002 17.9 0.2 0.0037 17.1 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.1 ESA22713.1 - 0.038 13.7 0.0 0.075 12.7 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_4 PF13420.1 ESA22713.1 - 0.044 13.7 0.1 0.075 12.9 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FAD_binding_3 PF01494.14 ESA22713.1 - 0.079 11.9 0.0 0.088 11.8 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain RAMP4 PF06624.7 ESA22714.1 - 3.9e-14 51.9 0.1 4.9e-14 51.6 0.1 1.1 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 gpUL132 PF11359.3 ESA22714.1 - 0.039 13.2 0.1 0.04 13.2 0.0 1.0 1 0 0 1 1 1 0 Glycoprotein UL132 F-box-like PF12937.2 ESA22716.1 - 0.00076 19.1 3.5 0.00079 19.1 1.1 2.1 2 0 0 2 2 2 1 F-box-like LRR_7 PF13504.1 ESA22716.1 - 4.3 7.9 18.3 37 5.1 0.1 6.6 7 3 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 ESA22716.1 - 8.9 6.7 16.3 8.2 6.8 0.2 5.9 5 1 0 5 5 5 0 Leucine Rich Repeat Pkinase PF00069.20 ESA22718.1 - 0.087 11.9 0.0 0.15 11.2 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain DUF2500 PF10694.4 ESA22718.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2500) Mga PF05043.8 ESA22719.1 - 0.0064 16.7 0.7 4.3 7.6 0.0 3.3 2 1 0 3 3 3 2 Mga helix-turn-helix domain DUF2342 PF10103.4 ESA22719.1 - 0.098 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2342) EF-hand_1 PF00036.27 ESA22719.1 - 0.18 11.1 1.0 0.47 9.8 0.1 2.2 2 0 0 2 2 2 0 EF hand BTB PF00651.26 ESA22721.1 - 7.5e-20 70.9 0.2 2.3e-19 69.4 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA22721.1 - 2.7e-15 56.5 1.8 6.4e-15 55.3 1.2 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA22721.1 - 4.2e-05 23.3 3.8 0.00015 21.5 0.1 3.7 4 1 1 5 5 5 1 BTB And C-terminal Kelch FF PF01846.14 ESA22722.1 - 8.4 6.4 10.5 4.8 7.2 1.4 3.4 2 1 1 3 3 3 0 FF domain DUF4379 PF14311.1 ESA22723.1 - 0.011 15.5 6.0 0.02 14.7 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4379) DUF3336 PF11815.3 ESA22726.1 - 0.033 13.7 0.0 0.091 12.2 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3336) Sel1 PF08238.7 ESA22727.1 - 8.3e-31 105.7 14.8 6.5e-12 45.6 1.1 4.0 4 0 0 4 4 4 4 Sel1 repeat MIT PF04212.13 ESA22727.1 - 0.0055 16.5 10.6 0.92 9.4 0.1 3.2 2 1 1 3 3 3 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.1 ESA22727.1 - 0.79 10.3 3.5 3.1 8.4 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA22727.1 - 4.3 7.4 13.8 7.5 6.7 0.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat SurA_N_3 PF13624.1 ESA22729.1 - 0.099 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Peptidase_S8 PF00082.17 ESA22730.1 - 1.3e-31 109.7 5.2 1.5e-31 109.6 3.6 1.0 1 0 0 1 1 1 1 Subtilase family DUF1027 PF06265.6 ESA22730.1 - 0.1 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) FANCI_S3 PF14677.1 ESA22736.1 - 0.014 14.8 1.3 0.073 12.4 0.6 1.9 2 0 0 2 2 2 0 FANCI solenoid 3 Dala_Dala_lig_C PF07478.8 ESA22736.1 - 0.084 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus TAXi_C PF14541.1 ESA22737.1 - 0.017 14.6 0.0 0.017 14.6 0.0 1.0 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Ycf66_N PF07444.6 ESA22738.1 - 0.14 11.9 0.2 0.14 11.9 0.1 2.4 3 0 0 3 3 3 0 Ycf66 protein N-terminus DUF4187 PF13821.1 ESA22738.1 - 1.3 8.7 4.2 0.28 10.7 0.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) Herpes_IR6 PF06307.7 ESA22739.1 - 0.025 13.9 0.1 0.041 13.2 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus IR6 protein IZUMO PF15005.1 ESA22740.1 - 0.096 12.7 0.3 0.41 10.6 0.1 1.9 2 0 0 2 2 2 0 Izumo sperm-egg fusion Endonuclease_7 PF02945.10 ESA22743.1 - 0.0042 16.7 4.5 0.013 15.1 0.0 3.0 3 0 0 3 3 3 1 Recombination endonuclease VII DUF4551 PF15087.1 ESA22744.1 - 1.5 7.0 13.8 1.8 6.8 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Tektin PF03148.9 ESA22750.1 - 0.11 11.0 0.0 0.13 10.7 0.0 1.0 1 0 0 1 1 1 0 Tektin family Patatin PF01734.17 ESA22751.1 - 1.7e-12 47.7 0.2 2.4e-12 47.2 0.2 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase DnaJ PF00226.26 ESA22752.1 - 0.0021 17.7 0.0 0.017 14.8 0.0 2.6 1 1 1 2 2 2 1 DnaJ domain Fis1_TPR_C PF14853.1 ESA22752.1 - 0.0055 16.5 1.0 0.021 14.6 0.7 2.1 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.12 ESA22752.1 - 1.5 8.9 9.8 11 6.2 0.5 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Patatin PF01734.17 ESA22753.1 - 5.6e-06 26.4 0.1 7.9e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase TPR_11 PF13414.1 ESA22753.1 - 0.02 14.5 0.6 0.051 13.2 0.3 1.9 1 1 1 2 2 2 0 TPR repeat PIF1 PF05970.9 ESA22754.1 - 1.9e-05 23.8 3.5 2.4e-05 23.4 2.4 1.1 1 0 0 1 1 1 1 PIF1-like helicase UvrD_C_2 PF13538.1 ESA22754.1 - 0.0008 19.5 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain PIF1 PF05970.9 ESA22755.1 - 1.4e-09 37.4 3.5 0.00052 19.0 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase DUF669 PF05037.8 ESA22755.1 - 0.074 12.9 0.2 13 5.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF669) Sec3_C_2 PF15278.1 ESA22756.1 - 0.03 14.4 0.7 0.053 13.6 0.5 1.5 1 0 0 1 1 1 0 Sec3 exocyst complex subunit BOF PF04076.8 ESA22757.1 - 0.12 12.2 0.2 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein PAH PF02671.16 ESA22759.1 - 0.093 12.3 0.6 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Paired amphipathic helix repeat LXG PF04740.7 ESA22759.1 - 0.27 10.9 2.7 10 5.8 0.1 2.1 2 0 0 2 2 2 0 LXG domain of WXG superfamily CRS1_YhbY PF01985.16 ESA22760.1 - 0.0052 16.7 0.2 0.0095 15.9 0.1 1.4 1 0 0 1 1 1 1 CRS1 / YhbY (CRM) domain N6_N4_Mtase PF01555.13 ESA22763.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 DNA methylase LRR_8 PF13855.1 ESA22764.1 - 0.005 16.5 10.6 0.11 12.3 0.1 3.9 3 1 0 3 3 3 2 Leucine rich repeat Mog1 PF04603.7 ESA22764.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Ran-interacting Mog1 protein LRR_4 PF12799.2 ESA22764.1 - 0.18 11.4 14.3 2 8.1 0.4 5.1 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) HSP20 PF00011.16 ESA22765.1 - 7.1e-24 83.6 0.2 8.7e-24 83.3 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 ESA22765.1 - 0.088 13.3 0.2 0.28 11.7 0.1 1.8 1 1 1 2 2 2 0 CS domain Pkinase PF00069.20 ESA22766.1 - 9.3e-34 116.7 0.1 2.3e-33 115.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22766.1 - 7.2e-33 113.7 0.0 9.1e-33 113.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_U32 PF01136.14 ESA22766.1 - 0.12 11.3 0.0 0.15 10.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family U32 APH PF01636.18 ESA22766.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DBD_Tnp_Mut PF03108.10 ESA22767.1 - 0.0031 17.0 0.2 0.0063 16.0 0.0 1.5 2 0 0 2 2 2 1 MuDR family transposase DUF547 PF04784.9 ESA22768.1 - 0.074 12.9 3.0 0.081 12.8 0.8 1.9 2 1 0 2 2 2 0 Protein of unknown function, DUF547 LRR_4 PF12799.2 ESA22769.1 - 1.6e-12 46.6 9.0 4.9e-05 22.8 0.7 5.4 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA22769.1 - 1.2e-05 24.8 17.3 0.0056 16.6 0.7 8.0 9 0 0 9 9 9 1 Leucine Rich repeat LRR_8 PF13855.1 ESA22769.1 - 4.1e-05 23.2 13.6 0.035 13.8 0.2 5.4 4 1 2 6 6 6 4 Leucine rich repeat F-box-like PF12937.2 ESA22769.1 - 5e-05 22.9 0.1 5e-05 22.9 0.0 2.8 3 1 0 3 3 3 1 F-box-like LRR_7 PF13504.1 ESA22769.1 - 0.023 14.8 12.7 0.63 10.4 0.3 6.2 9 0 0 9 9 9 0 Leucine rich repeat LRR_1 PF00560.28 ESA22769.1 - 0.091 12.8 0.5 0.091 12.8 0.4 7.6 7 2 1 8 8 8 0 Leucine Rich Repeat Herpes_Helicase PF02689.9 ESA22770.1 - 7.6e-05 20.6 0.0 8.1e-05 20.5 0.0 1.0 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 ESA22770.1 - 0.02 14.9 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain RNase_H PF00075.19 ESA22771.1 - 5.1e-14 52.7 0.1 9.8e-14 51.8 0.1 1.5 1 0 0 1 1 1 1 RNase H SET PF00856.23 ESA22772.1 - 1.3e-10 41.8 0.3 1.9e-09 38.0 0.2 2.0 1 1 0 1 1 1 1 SET domain RNase_H PF00075.19 ESA22773.1 - 1.4e-07 31.8 0.0 2.6e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 RNase H BTB PF00651.26 ESA22776.1 - 2.2e-12 46.9 0.0 5e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22776.1 - 4.2e-11 42.9 0.1 1e-10 41.7 0.1 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA22776.1 - 0.00012 21.8 1.6 0.00065 19.5 0.5 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA22777.1 - 4.1e-17 62.1 0.1 9.8e-17 60.9 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA22777.1 - 6.3e-15 55.3 2.5 6.3e-15 55.3 1.7 1.8 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22777.1 - 2.7e-05 23.9 4.3 9.5e-05 22.1 0.5 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch Ceramidase PF05875.7 ESA22779.1 - 1.6e-48 165.1 13.5 2.1e-48 164.7 9.4 1.2 1 0 0 1 1 1 1 Ceramidase DUF373 PF04123.8 ESA22779.1 - 2.6 6.9 8.1 3.8 6.4 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Ceramidase PF05875.7 ESA22780.1 - 3.3e-45 154.2 14.0 4.7e-45 153.7 9.7 1.2 1 0 0 1 1 1 1 Ceramidase DUF373 PF04123.8 ESA22780.1 - 0.93 8.4 8.3 1.4 7.9 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF4462 PF14692.1 ESA22781.1 - 0.29 10.4 2.4 1.1 8.5 1.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4462) AAA_12 PF13087.1 ESA22782.1 - 0.0047 16.3 0.5 0.006 15.9 0.3 1.2 1 0 0 1 1 1 1 AAA domain EMP70 PF02990.11 ESA22785.1 - 2.2e-160 534.5 22.3 2.8e-160 534.2 15.5 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 PPR_2 PF13041.1 ESA22786.1 - 1.2e-32 111.6 20.0 7.1e-10 38.7 0.0 9.3 4 2 6 10 10 9 7 PPR repeat family PPR PF01535.15 ESA22786.1 - 1.8e-27 93.3 8.4 8e-07 28.6 0.0 8.9 8 1 0 8 8 8 4 PPR repeat PPR_3 PF13812.1 ESA22786.1 - 8.6e-21 72.4 0.0 0.00038 20.5 0.0 7.7 8 0 0 8 8 7 3 Pentatricopeptide repeat domain PPR_1 PF12854.2 ESA22786.1 - 3.2e-13 48.8 8.8 9.6e-08 31.3 0.0 6.0 6 1 0 6 6 6 3 PPR repeat MRP-S27 PF10037.4 ESA22786.1 - 5.8e-08 32.0 5.0 2.9e-05 23.1 0.3 2.9 2 1 1 3 3 3 2 Mitochondrial 28S ribosomal protein S27 TPR_19 PF14559.1 ESA22786.1 - 2.6e-07 30.8 0.1 0.022 15.0 0.0 4.9 4 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA22786.1 - 5.9e-06 25.6 0.0 0.2 11.5 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 ESA22786.1 - 9.3e-05 22.2 0.4 2 8.4 0.0 4.8 2 2 4 6 6 6 2 Tetratricopeptide repeat ECSIT PF06239.6 ESA22786.1 - 0.0024 16.7 5.1 0.13 11.1 0.0 3.2 2 2 1 3 3 3 2 Evolutionarily conserved signalling intermediate in Toll pathway Clathrin PF00637.15 ESA22786.1 - 0.0098 15.5 6.7 1.2 8.7 0.1 3.4 2 1 1 3 3 3 2 Region in Clathrin and VPS TPR_14 PF13428.1 ESA22786.1 - 0.013 16.0 0.0 46 5.0 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA22786.1 - 0.026 14.9 1.6 1.1e+02 3.5 0.0 5.2 7 0 0 7 7 6 0 Tetratricopeptide repeat SPOB_a PF14689.1 ESA22786.1 - 0.035 13.6 0.1 7.9 6.1 0.0 3.1 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_2 PF07719.12 ESA22786.1 - 0.064 13.1 5.0 52 4.1 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.1 ESA22786.1 - 0.23 11.3 4.0 2.9 7.8 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA22786.1 - 1.5 8.5 3.8 8.1 6.2 0.0 4.0 6 0 0 6 6 6 0 Tetratricopeptide repeat SPT6_acidic PF14632.1 ESA22787.1 - 0.56 10.4 6.1 0.39 10.9 2.1 2.3 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Rota_Capsid_VP6 PF00980.12 ESA22788.1 - 0.029 13.0 0.4 0.034 12.7 0.3 1.1 1 0 0 1 1 1 0 Rotavirus major capsid protein VP6 gpUL132 PF11359.3 ESA22788.1 - 0.06 12.6 0.0 0.088 12.1 0.0 1.3 1 1 0 1 1 1 0 Glycoprotein UL132 DUF3891 PF13030.1 ESA22788.1 - 0.077 12.4 0.1 0.081 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) PPR_2 PF13041.1 ESA22790.1 - 1.9e-73 242.2 52.7 2.1e-15 56.3 0.5 10.7 4 2 8 12 12 12 10 PPR repeat family PPR_1 PF12854.2 ESA22790.1 - 9.6e-42 140.1 21.9 4.5e-07 29.2 0.0 10.7 11 0 0 11 11 11 8 PPR repeat PPR_3 PF13812.1 ESA22790.1 - 1.7e-39 130.7 2.0 0.00068 19.7 0.0 12.1 14 1 0 14 14 13 6 Pentatricopeptide repeat domain PPR PF01535.15 ESA22790.1 - 5.8e-39 129.3 43.2 2.1e-06 27.2 0.1 12.6 14 1 0 14 14 13 8 PPR repeat MRP-S27 PF10037.4 ESA22790.1 - 7.4e-06 25.1 3.5 0.31 9.9 0.0 4.9 3 2 2 6 6 6 2 Mitochondrial 28S ribosomal protein S27 ECSIT PF06239.6 ESA22790.1 - 9.7e-06 24.6 9.7 0.046 12.5 1.0 5.5 3 2 2 5 5 5 1 Evolutionarily conserved signalling intermediate in Toll pathway ATP13 PF12921.2 ESA22790.1 - 8.9e-05 21.8 7.6 2 7.7 0.0 5.9 4 1 4 8 8 8 2 Mitochondrial ATPase expression TPR_2 PF07719.12 ESA22790.1 - 0.0025 17.6 5.3 6.3 6.9 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat SBP_bac_6 PF13343.1 ESA22790.1 - 0.037 13.3 0.4 1.7 7.9 0.0 3.3 3 1 1 4 4 4 0 Bacterial extracellular solute-binding protein TPR_12 PF13424.1 ESA22790.1 - 0.082 12.8 1.8 4.2 7.3 0.1 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA22790.1 - 0.15 11.9 1.2 39 4.3 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.15 ESA22790.1 - 0.17 11.4 19.3 2.1 7.9 0.8 5.6 4 2 1 5 5 5 0 Region in Clathrin and VPS DUF849 PF05853.7 ESA22790.1 - 0.21 10.4 0.4 14 4.4 0.0 2.6 2 1 0 2 2 2 0 Prokaryotic protein of unknown function (DUF849) CLTH PF10607.4 ESA22791.1 - 9.5e-35 119.4 3.2 2.6e-34 118.0 0.2 2.1 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.1 ESA22791.1 - 2.5e-17 62.3 1.3 6.8e-17 60.9 0.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA22791.1 - 0.00055 19.5 0.2 0.0011 18.6 0.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 ESA22791.1 - 0.005 16.6 0.1 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 ESA22791.1 - 0.012 15.2 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA22791.1 - 0.02 14.7 0.1 0.05 13.4 0.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 ESA22791.1 - 0.021 14.8 0.2 0.043 13.8 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 ESA22791.1 - 0.079 12.5 0.2 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.20 ESA22791.1 - 0.079 12.6 0.2 0.17 11.5 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IZUMO PF15005.1 ESA22791.1 - 0.22 11.5 6.5 2.6 8.0 2.0 2.6 3 0 0 3 3 3 0 Izumo sperm-egg fusion Glyco_trans_1_3 PF13528.1 ESA22792.1 - 1.6e-09 37.3 0.0 8.2e-06 25.2 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 ESA22792.1 - 0.005 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UQ_con PF00179.21 ESA22793.1 - 5.9e-28 97.0 0.1 1.1e-27 96.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA22793.1 - 0.044 13.5 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 ESA22793.1 - 0.099 12.5 0.1 0.28 11.0 0.1 1.8 1 0 0 1 1 1 0 RWD domain CH PF00307.26 ESA22794.1 - 0.04 13.9 1.5 0.11 12.5 0.3 2.2 1 1 1 2 2 2 0 Calponin homology (CH) domain Terminase_3 PF04466.8 ESA22795.1 - 0.014 14.5 2.0 0.014 14.4 1.4 1.1 1 0 0 1 1 1 0 Phage terminase large subunit IBD PF10416.4 ESA22795.1 - 0.11 12.3 3.2 0.19 11.5 0.4 2.0 1 1 1 2 2 2 0 Transcription-initiator DNA-binding domain IBD TLD PF07534.11 ESA22796.1 - 2.4e-11 43.7 0.6 3.6e-11 43.2 0.4 1.3 1 0 0 1 1 1 1 TLD DUF4597 PF15366.1 ESA22797.1 - 0.24 10.9 1.6 0.24 10.9 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4597) CHIPS PF11434.3 ESA22800.1 - 0.062 12.9 0.1 0.81 9.3 0.1 2.3 2 1 1 3 3 3 0 Chemotaxis-inhibiting protein CHIPS Ion_trans PF00520.26 ESA22801.1 - 0.003 16.8 6.0 0.004 16.4 4.2 1.2 1 0 0 1 1 1 1 Ion transport protein TRP PF06011.7 ESA22801.1 - 0.0072 14.9 3.5 0.0094 14.5 2.4 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF4271 PF14093.1 ESA22801.1 - 0.031 13.9 5.4 0.045 13.4 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) DUF3585 PF12130.3 ESA22802.1 - 0.029 14.2 0.1 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3585) IpaB_EvcA PF03278.8 ESA22803.1 - 0.015 14.5 0.3 0.02 14.0 0.2 1.3 1 0 0 1 1 1 0 IpaB/EvcA family RNA_Me_trans PF04252.8 ESA22803.1 - 0.041 13.2 0.0 0.07 12.5 0.0 1.5 1 1 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase DUF3966 PF13110.1 ESA22803.1 - 0.064 13.0 0.6 0.2 11.4 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3966) PadR PF03551.9 ESA22804.1 - 0.016 14.9 0.4 0.032 14.0 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family Remorin_C PF03763.8 ESA22804.1 - 0.064 12.7 1.2 0.1 12.1 0.8 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region Pkinase PF00069.20 ESA22805.1 - 4.6e-35 121.0 0.4 6.2e-35 120.5 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22805.1 - 8.8e-32 110.1 0.0 1.1e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.12 ESA22806.1 - 1.2e-34 119.5 0.0 1.6e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22806.1 - 1.7e-33 115.9 0.0 3.2e-33 114.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA22806.1 - 0.081 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.26 ESA22807.1 - 1.4e-15 57.2 0.0 1.6e-15 57.0 0.0 1.0 1 0 0 1 1 1 1 BTB/POZ domain Pkinase_Tyr PF07714.12 ESA22808.1 - 1.9e-10 40.2 0.0 2.9e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22808.1 - 2.4e-06 26.8 0.1 6.6e-06 25.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Med1 PF10744.4 ESA22810.1 - 1.4e-11 43.8 0.1 1.8e-11 43.4 0.1 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 Epsilon_antitox PF08998.6 ESA22810.1 - 0.024 14.5 0.9 0.024 14.5 0.6 2.8 3 0 0 3 3 3 0 Bacterial epsilon antitoxin Desmo_N PF06771.6 ESA22810.1 - 0.11 12.4 0.3 0.35 10.8 0.1 1.9 1 1 1 2 2 2 0 Viral Desmoplakin N-terminus HMG_box PF00505.14 ESA22811.1 - 4.4e-05 23.6 1.3 7.8e-05 22.8 0.9 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA22811.1 - 0.00027 21.2 0.6 0.00047 20.4 0.4 1.3 1 0 0 1 1 1 1 HMG-box domain DUF496 PF04363.7 ESA22811.1 - 0.043 13.6 0.2 0.072 12.9 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF496) CKAP2_C PF15297.1 ESA22811.1 - 0.093 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus SH3_1 PF00018.23 ESA22812.1 - 5.7e-12 44.8 0.1 1.1e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 ESA22812.1 - 3.2e-09 36.2 0.0 5.6e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 ESA22812.1 - 3.3e-07 29.7 0.0 5.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF707 PF05212.7 ESA22812.1 - 0.13 11.3 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF707) DUF3980 PF13140.1 ESA22812.1 - 4 7.7 7.6 1.1 9.6 2.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3980) Fructosamin_kin PF03881.9 ESA22813.1 - 2.6e-81 272.7 0.0 3.1e-81 272.5 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 ESA22813.1 - 1.5e-11 44.5 0.0 2.2e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 ESA22813.1 - 0.034 12.7 0.0 0.034 12.7 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) DUF848 PF05852.6 ESA22814.1 - 0.028 14.2 2.2 0.028 14.2 1.5 1.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TMF_TATA_bd PF12325.3 ESA22814.1 - 0.041 13.5 6.7 0.065 12.9 4.6 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CAF-1_p150 PF11600.3 ESA22814.1 - 0.12 11.7 14.1 0.14 11.4 9.8 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal KLRAQ PF10205.4 ESA22814.1 - 0.21 11.6 9.1 0.42 10.6 4.2 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein IncA PF04156.9 ESA22814.1 - 10 5.6 9.2 15 5.1 6.4 1.2 1 0 0 1 1 1 0 IncA protein TLD PF07534.11 ESA22816.1 - 1.5e-13 50.8 0.9 3.2e-13 49.8 0.6 1.6 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA22817.1 - 1.3e-16 60.5 0.1 3e-16 59.3 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22817.1 - 2.3e-05 24.1 3.6 0.00011 22.0 0.3 3.0 3 1 1 4 4 4 1 BTB And C-terminal Kelch TLD PF07534.11 ESA22817.1 - 0.0013 18.6 0.1 0.0079 16.1 0.0 2.2 2 0 0 2 2 2 1 TLD DUF2624 PF11116.3 ESA22817.1 - 2.1 8.9 6.0 0.5 10.9 0.6 2.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2624) MULE PF10551.4 ESA22818.1 - 3.7e-07 30.2 0.1 5.2e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 MULE transposase domain DUF4042 PF13251.1 ESA22818.1 - 0.017 14.6 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) TLD PF07534.11 ESA22820.1 - 6e-20 71.6 2.1 6e-20 71.6 1.5 2.0 2 1 0 2 2 2 1 TLD BTB PF00651.26 ESA22820.1 - 4.2e-09 36.3 0.5 1.3e-08 34.8 0.1 2.1 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA22820.1 - 1.4e-07 31.2 0.5 1.9e-06 27.6 0.1 2.9 3 1 0 3 3 3 1 BTB And C-terminal Kelch CRAL_TRIO PF00650.15 ESA22823.1 - 8.5e-41 139.1 0.8 1.3e-40 138.5 0.2 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESA22823.1 - 1.5e-12 47.4 0.1 1.5e-12 47.4 0.1 2.8 3 0 0 3 3 3 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 ESA22823.1 - 1e-08 35.1 0.1 2.7e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RILP PF11461.3 ESA22823.1 - 0.058 13.5 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 Rab interacting lysosomal protein Sel1 PF08238.7 ESA22824.1 - 1.7e-144 467.0 61.9 3.4e-12 46.5 0.4 15.2 15 0 0 15 15 15 15 Sel1 repeat TPR_6 PF13174.1 ESA22824.1 - 0.00011 22.4 13.5 88 3.9 0.0 10.2 12 1 0 12 12 12 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA22824.1 - 0.0016 18.4 12.5 31 5.1 0.2 8.8 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA22824.1 - 0.0017 17.9 37.1 0.36 10.4 0.6 9.2 5 3 3 9 9 9 4 TPR repeat Sec10 PF07393.6 ESA22825.1 - 4.2e-213 709.5 12.6 5e-211 702.6 8.7 2.1 1 1 0 1 1 1 1 Exocyst complex component Sec10 Vps51 PF08700.6 ESA22825.1 - 0.00046 19.9 0.4 0.0032 17.2 0.0 2.8 3 0 0 3 3 3 1 Vps51/Vps67 COG4 PF08318.7 ESA22825.1 - 0.00068 18.4 1.4 0.00072 18.4 0.1 1.7 2 0 0 2 2 2 1 COG4 transport protein Evr1_Alr PF04777.8 ESA22825.1 - 0.91 9.4 3.6 3.1 7.7 0.4 2.9 3 0 0 3 3 3 0 Erv1 / Alr family TGT PF01702.13 ESA22826.1 - 4.3e-91 304.4 0.0 5.2e-91 304.1 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Adaptin_binding PF10199.4 ESA22827.1 - 3e-17 63.1 0.8 4.6e-17 62.5 0.5 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Miro PF08477.8 ESA22827.1 - 1.4e-05 25.6 0.1 3.8e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 Miro-like protein AAA_14 PF13173.1 ESA22827.1 - 0.024 14.5 1.0 0.039 13.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain Ras PF00071.17 ESA22827.1 - 0.038 13.3 0.8 0.39 10.1 0.2 2.4 2 1 0 2 2 2 0 Ras family DUF815 PF05673.8 ESA22827.1 - 0.064 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF258 PF03193.11 ESA22827.1 - 0.074 12.2 0.3 0.16 11.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 ESA22827.1 - 0.31 11.8 4.6 0.87 10.4 0.6 2.6 1 1 1 2 2 2 0 AAA domain PPR_2 PF13041.1 ESA22828.1 - 1.6e-27 95.1 7.7 1.1e-07 31.6 0.0 8.0 5 2 3 8 8 8 7 PPR repeat family PPR_3 PF13812.1 ESA22828.1 - 2.4e-25 86.6 0.2 0.00064 19.8 0.0 9.9 10 0 0 10 10 10 4 Pentatricopeptide repeat domain PPR PF01535.15 ESA22828.1 - 1.4e-15 56.1 11.1 0.011 15.6 0.1 8.2 8 1 0 8 8 8 5 PPR repeat PPR_1 PF12854.2 ESA22828.1 - 4.7e-05 22.7 3.2 1.2 8.6 0.0 5.3 6 0 0 6 6 6 2 PPR repeat VirC1 PF07015.6 ESA22828.1 - 0.018 14.1 0.2 0.13 11.3 0.0 2.2 3 0 0 3 3 3 0 VirC1 protein Histone PF00125.19 ESA22829.1 - 2.5e-29 101.2 0.3 3.7e-29 100.6 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 ESA22829.1 - 0.003 17.6 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 ESA22829.1 - 0.098 12.7 0.4 0.098 12.7 0.3 1.6 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 ESA22829.1 - 0.18 11.0 0.1 0.18 11.0 0.1 1.7 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T Ribosomal_L38e PF01781.13 ESA22830.1 - 7.4e-33 112.1 4.6 8.1e-33 112.0 3.2 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family PIGA PF08288.7 ESA22831.1 - 1.9e-45 153.1 1.0 4e-45 152.1 0.7 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 ESA22831.1 - 1.6e-28 99.2 0.0 2.7e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 ESA22831.1 - 6.3e-18 65.1 0.4 9.7e-18 64.5 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 ESA22831.1 - 5e-12 46.2 0.0 9.6e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 ESA22831.1 - 1.8e-11 44.3 0.0 3.5e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 ESA22831.1 - 1.5e-06 28.1 0.5 2.5e-06 27.3 0.4 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 ESA22831.1 - 0.00016 21.8 0.0 0.00051 20.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Sgf11 PF08209.6 ESA22833.1 - 1.1e-11 43.8 0.2 1.1e-11 43.8 0.1 1.6 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) Plant_vir_prot PF01307.12 ESA22834.1 - 0.069 12.8 0.6 0.13 11.9 0.4 1.5 1 0 0 1 1 1 0 Plant viral movement protein DUF1199 PF06712.6 ESA22834.1 - 0.3 10.9 9.5 2.9 7.7 0.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1199) WD40 PF00400.27 ESA22835.1 - 2.9e-42 141.0 15.9 5.7e-10 38.6 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA22835.1 - 4.8e-05 23.1 0.0 0.011 15.4 0.0 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ESA22835.1 - 0.00067 17.9 0.3 0.021 12.9 0.0 2.2 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 ESA22835.1 - 0.0013 17.5 0.7 0.57 8.8 0.1 2.6 1 1 1 2 2 2 2 Nup133 N terminal like HPS3_N PF14761.1 ESA22835.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 Cytochrom_D1 PF02239.11 ESA22835.1 - 0.015 13.6 1.0 0.25 9.6 0.0 2.6 1 1 0 2 2 2 0 Cytochrome D1 heme domain PQQ_2 PF13360.1 ESA22835.1 - 0.029 13.8 0.3 1.9 7.9 0.0 2.7 2 1 0 2 2 2 0 PQQ-like domain USP7_C2 PF14533.1 ESA22835.1 - 0.079 12.3 0.0 0.29 10.5 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-specific protease C-terminal Sel1 PF08238.7 ESA22836.1 - 0.008 16.7 0.1 2.6 8.7 0.0 2.6 2 0 0 2 2 2 2 Sel1 repeat F-box-like PF12937.2 ESA22837.1 - 2.2e-07 30.4 1.4 2.4e-06 27.1 0.5 2.6 3 0 0 3 3 3 1 F-box-like Pox_A3L PF05288.6 ESA22837.1 - 0.2 11.3 0.2 0.2 11.3 0.1 3.5 3 1 0 3 3 3 0 Poxvirus A3L Protein PUF PF00806.14 ESA22838.1 - 0.00019 20.6 0.1 0.00047 19.4 0.0 1.7 1 0 0 1 1 1 1 Pumilio-family RNA binding repeat PAS_5 PF07310.8 ESA22838.1 - 0.0052 16.3 0.0 0.0085 15.6 0.0 1.3 1 0 0 1 1 1 1 PAS domain zf-C2H2 PF00096.21 ESA22838.1 - 0.0075 16.5 3.5 0.031 14.6 2.4 2.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type Gemini_AL1_M PF08283.6 ESA22838.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Geminivirus rep protein central domain DUF1098 PF06497.6 ESA22839.1 - 0.052 13.6 0.8 0.052 13.6 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1098) TFIIS_M PF07500.9 ESA22841.1 - 6e-16 58.5 0.4 7.1e-16 58.3 0.3 1.1 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain DUF481 PF04338.7 ESA22843.1 - 0.012 15.3 0.7 0.019 14.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF481 DUF4373 PF14297.1 ESA22843.1 - 0.12 12.7 1.1 0.96 9.7 0.3 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF4373) DUF2439 PF10382.4 ESA22843.1 - 0.5 10.6 6.8 3.3 7.9 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) Pkinase PF00069.20 ESA22844.1 - 2.4e-41 141.5 0.1 3.6e-41 141.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22844.1 - 9.6e-37 126.4 0.0 1.2e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA22844.1 - 0.0001 22.1 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA22844.1 - 0.0006 19.2 0.1 0.0015 17.8 0.0 1.6 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.9 ESA22844.1 - 0.01 14.9 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PcfJ PF14284.1 ESA22844.1 - 0.011 15.2 0.1 0.02 14.4 0.1 1.4 1 0 0 1 1 1 0 PcfJ-like protein WaaY PF06176.6 ESA22844.1 - 0.012 14.8 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA22844.1 - 0.042 12.7 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RNase_E_G PF10150.4 ESA22845.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribonuclease E/G family DUF3990 PF13151.1 ESA22846.1 - 0.11 11.9 0.3 0.11 11.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Mtp PF03821.11 ESA22847.1 - 0.032 13.6 0.1 0.032 13.6 0.1 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter DUF2650 PF10853.3 ESA22847.1 - 0.31 10.5 2.4 0.62 9.5 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) P3A PF08727.6 ESA22848.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Poliovirus 3A protein like TIR PF01582.15 ESA22849.1 - 0.052 12.9 0.4 0.061 12.7 0.3 1.2 1 0 0 1 1 1 0 TIR domain GMC_oxred_N PF00732.14 ESA22850.1 - 5.4e-56 189.9 0.0 7.5e-37 127.0 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.8 ESA22850.1 - 3.5e-34 118.1 0.0 1.2e-33 116.4 0.0 1.9 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.7 ESA22850.1 - 0.00056 18.9 0.0 0.00085 18.3 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.19 ESA22850.1 - 0.0017 17.3 0.0 0.0034 16.3 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 ESA22850.1 - 0.027 14.5 0.0 0.088 12.8 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Myc_N PF01056.13 ESA22851.1 - 0.036 13.2 1.3 0.04 13.0 0.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region BTB PF00651.26 ESA22852.1 - 1.3e-10 41.2 0.2 2.4e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22852.1 - 9e-05 22.2 0.7 0.00036 20.3 0.1 2.3 2 1 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA22853.1 - 1.6e-15 57.3 2.9 1.6e-15 57.3 2.0 1.8 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA22853.1 - 2.3e-11 43.6 0.9 9.8e-11 41.6 0.1 2.4 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA22853.1 - 1.2e-06 28.3 1.2 3.2e-05 23.7 0.1 3.5 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3942 PF13078.1 ESA22853.1 - 0.026 14.5 0.3 0.081 13.0 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) TLD PF07534.11 ESA22854.1 - 7.4e-12 45.4 1.6 1.9e-11 44.1 1.1 1.7 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA22854.1 - 8.4e-12 45.0 0.1 1.7e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA22854.1 - 8.4e-06 25.5 0.6 4.7e-05 23.1 0.1 2.5 1 1 1 2 2 2 1 BTB And C-terminal Kelch BUD22 PF09073.5 ESA22855.1 - 2 7.3 27.5 2.9 6.8 19.0 1.4 1 1 0 1 1 1 0 BUD22 CwfJ_C_2 PF04676.9 ESA22856.1 - 1.4e-26 92.8 0.6 2.2e-26 92.1 0.5 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.10 ESA22856.1 - 5.3e-24 84.2 0.1 7.3e-24 83.7 0.1 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 HTH_33 PF13592.1 ESA22856.1 - 0.13 11.8 0.5 0.26 10.8 0.3 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Uma2 PF05685.7 ESA22858.1 - 0.002 17.5 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease DUF4545 PF15078.1 ESA22859.1 - 0.0018 17.3 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4545) Taxilin PF09728.4 ESA22860.1 - 3.1e-85 285.9 67.2 3.5e-85 285.8 46.6 1.0 1 0 0 1 1 1 1 Myosin-like coiled-coil protein GAS PF13851.1 ESA22860.1 - 0.074 12.2 59.2 0.19 10.8 4.0 3.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 ESA22860.1 - 0.89 9.3 54.2 0.028 14.1 6.9 4.3 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding NTR2 PF15458.1 ESA22861.1 - 5.1e-15 55.4 7.9 5.1e-15 55.4 5.5 2.5 1 1 0 2 2 2 1 Nineteen complex-related protein 2 GCFC PF07842.7 ESA22861.1 - 1.1e-13 51.2 2.8 7e-10 38.7 2.0 3.5 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein CLAMP PF14769.1 ESA22861.1 - 0.024 14.7 4.9 0.052 13.7 0.1 3.1 2 1 1 3 3 3 0 Flagellar C1a complex subunit C1a-32 KIF1B PF12423.3 ESA22861.1 - 0.028 14.4 0.2 0.12 12.4 0.1 2.2 2 0 0 2 2 2 0 Kinesin protein 1B Olfactory_mark PF06554.7 ESA22861.1 - 0.09 12.3 3.2 0.062 12.8 0.3 2.0 2 0 0 2 2 2 0 Olfactory marker protein DUF4604 PF15377.1 ESA22862.1 - 0.078 13.1 4.4 0.095 12.9 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF155 PF02582.9 ESA22863.1 - 4.6e-61 205.7 1.0 6.8e-61 205.2 0.7 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 PITH PF06201.8 ESA22864.1 - 1.1e-41 142.1 6.8 1.3e-41 141.9 4.7 1.0 1 0 0 1 1 1 1 PITH domain Peptidase_A2B PF12384.3 ESA22864.1 - 0.068 12.5 0.6 0.1 11.9 0.4 1.4 1 0 0 1 1 1 0 Ty3 transposon peptidase Pkinase_Tyr PF07714.12 ESA22866.1 - 3.9e-36 124.4 1.0 7.1e-36 123.6 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22866.1 - 2.2e-32 112.2 1.0 2.2e-32 112.2 0.7 2.1 2 0 0 2 2 2 1 Protein kinase domain VirC1 PF07015.6 ESA22868.1 - 0.089 11.8 0.0 0.1 11.6 0.0 1.0 1 0 0 1 1 1 0 VirC1 protein TLD PF07534.11 ESA22870.1 - 0.0013 18.7 0.2 0.0014 18.6 0.1 1.2 1 0 0 1 1 1 1 TLD PSI PF01437.20 ESA22871.1 - 0.00015 21.8 8.4 0.00019 21.5 5.8 1.2 1 0 0 1 1 1 1 Plexin repeat Nodulin_late PF07127.6 ESA22871.1 - 0.64 10.1 4.2 2.1 8.5 2.9 2.0 1 1 0 1 1 1 0 Late nodulin protein HMG_box PF00505.14 ESA22872.1 - 7.4e-08 32.5 0.1 1.2e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA22872.1 - 0.085 13.2 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 HMG-box domain UPF0113 PF03657.8 ESA22873.1 - 9.1e-06 25.4 0.0 1.2e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) PP1 PF07430.6 ESA22873.1 - 0.076 12.5 0.0 0.14 11.7 0.0 1.4 2 0 0 2 2 2 0 Phloem filament protein PP1 Tim44 PF04280.10 ESA22874.1 - 5.6e-33 114.0 0.2 5.6e-33 114.0 0.2 1.8 2 0 0 2 2 2 1 Tim44-like domain OmpH PF03938.9 ESA22874.1 - 0.09 12.7 11.8 0.55 10.1 8.2 2.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF445 PF04286.7 ESA22874.1 - 4.2 6.8 11.2 1.7 8.1 4.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Phage_DsbA PF11126.3 ESA22876.1 - 0.042 13.9 5.5 0.31 11.1 0.1 2.4 2 0 0 2 2 2 0 Transcriptional regulator DsbA DUF1833 PF08875.6 ESA22876.1 - 0.084 12.0 1.3 0.52 9.4 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1833) DDE_Tnp_4 PF13359.1 ESA22877.1 - 0.0012 18.4 0.1 0.2 11.2 0.0 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease Glyco_hydro_9 PF00759.14 ESA22879.1 - 1.7e-101 340.2 4.2 2e-101 340.0 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Septin PF00735.13 ESA22881.1 - 3.5e-71 239.5 0.4 4.8e-71 239.0 0.3 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 ESA22881.1 - 8.1e-08 32.2 0.1 2.5e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 ESA22881.1 - 9e-06 25.2 0.0 0.037 13.4 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 ESA22881.1 - 0.0021 17.9 2.6 0.43 10.3 0.0 2.8 2 1 1 3 3 3 2 Dynamin family AAA_22 PF13401.1 ESA22881.1 - 0.015 15.4 0.3 0.1 12.7 0.1 2.5 2 1 1 3 3 3 0 AAA domain MobB PF03205.9 ESA22881.1 - 0.056 13.1 0.0 0.37 10.5 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 ESA22881.1 - 0.097 13.1 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Peptidase_M28 PF04389.12 ESA22882.1 - 2.7e-29 102.1 0.0 4.8e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 ESA22882.1 - 1.8e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Nicastrin PF05450.10 ESA22882.1 - 0.016 14.4 0.2 0.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Nicastrin Vpu PF00558.14 ESA22883.1 - 0.97 9.0 3.3 0.59 9.7 1.4 1.3 1 1 0 1 1 1 0 Vpu protein Sds3 PF08598.6 ESA22886.1 - 7.5e-08 32.1 11.0 8.5e-08 31.9 7.6 1.0 1 0 0 1 1 1 1 Sds3-like SpvB PF03534.8 ESA22886.1 - 0.054 12.4 0.3 0.059 12.3 0.2 1.1 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein Peptidase_M91 PF14891.1 ESA22886.1 - 0.11 12.5 0.7 0.14 12.2 0.5 1.2 1 0 0 1 1 1 0 Effector protein Drf_GBD PF06371.8 ESA22886.1 - 6.6 6.0 8.3 52 3.1 5.7 2.0 1 1 0 1 1 1 0 Diaphanous GTPase-binding Domain RRM_1 PF00076.17 ESA22888.1 - 2e-27 94.5 3.2 1.6e-17 62.9 0.1 3.4 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22888.1 - 3.5e-21 74.9 1.2 2.5e-13 49.7 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA22888.1 - 6.4e-18 64.3 2.5 1.2e-09 37.8 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA22888.1 - 0.00027 20.6 0.1 0.01 15.6 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.8 ESA22888.1 - 0.0012 18.5 0.6 0.79 9.5 0.0 2.6 1 1 1 2 2 2 2 Nup53/35/40-type RNA recognition motif LIM_bind PF01803.11 ESA22888.1 - 0.035 13.2 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 LIM-domain binding protein DUF1882 PF08966.6 ESA22888.1 - 0.067 13.1 0.4 2.1 8.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) Pkinase_Tyr PF07714.12 ESA22890.1 - 6.9e-24 84.3 0.0 1.5e-21 76.6 0.0 3.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22890.1 - 4.9e-21 75.0 0.0 2e-19 69.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA22890.1 - 0.0072 16.9 1.5 0.0084 16.7 0.1 1.9 2 0 0 2 2 2 1 Sel1 repeat TLD PF07534.11 ESA22891.1 - 9.2e-17 61.3 3.5 9.2e-17 61.3 2.4 1.7 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22891.1 - 4.3e-08 32.9 0.1 1.4e-07 31.2 0.0 2.0 1 1 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 ESA22891.1 - 0.06 13.3 0.1 0.19 11.7 0.1 1.9 1 0 0 1 1 1 0 BTB/POZ domain Sel1 PF08238.7 ESA22892.1 - 1.5e-101 330.6 53.3 1.3e-11 44.7 0.4 11.8 12 0 0 12 12 12 11 Sel1 repeat BTB PF00651.26 ESA22892.1 - 5.2e-20 71.4 2.1 3.5e-19 68.8 0.1 2.6 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA22892.1 - 1.5e-11 44.4 0.3 1.5e-11 44.4 0.2 2.6 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA22892.1 - 4.7e-07 29.6 3.4 6.4e-06 25.9 0.2 3.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch IR1-M PF12185.3 ESA22892.1 - 0.89 9.3 5.4 1.4e+02 2.3 0.0 5.2 7 0 0 7 7 7 0 Nup358/RanBP2 E3 ligase domain CM1 PF03026.10 ESA22893.1 - 0.032 13.3 0.1 0.034 13.2 0.1 1.0 1 0 0 1 1 1 0 Influenza C virus M1 protein Ribosomal_L35p PF01632.14 ESA22893.1 - 0.15 11.9 1.7 0.23 11.3 1.2 1.2 1 0 0 1 1 1 0 Ribosomal protein L35 PfUIS3 PF11567.3 ESA22894.1 - 0.057 13.5 1.7 0.093 12.8 1.2 1.3 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein UQ_con PF00179.21 ESA22895.1 - 1.4e-13 50.4 0.0 1.5e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Paf67 PF10255.4 ESA22897.1 - 0.09 11.6 0.1 0.099 11.5 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 p450 PF00067.17 ESA22898.1 - 2.2e-41 141.8 0.1 2.6e-41 141.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.20 ESA22901.1 - 5.3e-30 104.4 0.0 7.2e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22901.1 - 6e-30 104.1 0.0 7.4e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA22901.1 - 0.061 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family XFP PF03894.10 ESA22902.1 - 0.003 17.1 0.1 0.0042 16.6 0.1 1.2 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DUF3826 PF12875.2 ESA22902.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) LRR_4 PF12799.2 ESA22903.1 - 0.76 9.4 17.9 1.4 8.6 0.5 5.4 2 2 1 3 3 3 0 Leucine Rich repeats (2 copies) DUF3157 PF11355.3 ESA22905.1 - 0.079 12.2 0.2 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3157) Phage_connect_1 PF05135.8 ESA22905.1 - 0.21 11.7 2.7 3.1 8.0 0.4 2.6 2 0 0 2 2 2 0 Phage gp6-like head-tail connector protein DUF3991 PF13154.1 ESA22910.1 - 0.059 13.5 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3991) SpoU_methylas_C PF12105.3 ESA22910.1 - 0.13 11.8 0.8 0.16 11.5 0.0 1.6 2 0 0 2 2 2 0 SpoU, rRNA methylase, C-terminal Mpv17_PMP22 PF04117.7 ESA22912.1 - 0.088 12.4 0.4 0.3 10.7 0.1 2.0 1 1 0 1 1 1 0 Mpv17 / PMP22 family DUF3278 PF11683.3 ESA22912.1 - 0.096 12.6 2.1 0.11 12.4 1.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) DUF624 PF04854.9 ESA22912.1 - 0.15 11.9 1.4 0.35 10.7 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function, DUF624 E1_DerP2_DerF2 PF02221.10 ESA22915.1 - 1.3e-09 38.3 0.7 1.6e-09 38.0 0.5 1.1 1 0 0 1 1 1 1 ML domain DUF3439 PF11921.3 ESA22915.1 - 2.3 7.9 7.4 0.48 10.1 2.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3439) DUF4378 PF14309.1 ESA22916.1 - 0.09 12.8 0.1 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) UQ_con PF00179.21 ESA22917.1 - 2.9e-46 156.3 0.0 3.4e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESA22917.1 - 0.02 14.5 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 UEV domain RRM_1 PF00076.17 ESA22918.1 - 1.9e-05 24.1 0.0 0.011 15.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA22918.1 - 0.00054 19.8 0.0 0.0095 15.8 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.17 ESA22918.1 - 3.2 6.6 4.4 3.8 6.4 3.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter UQ_con PF00179.21 ESA22920.1 - 1.1e-46 157.7 0.0 1.2e-46 157.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA22920.1 - 0.0023 17.8 0.1 0.0031 17.3 0.0 1.4 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 ESA22920.1 - 0.0023 17.7 0.0 0.0029 17.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 ESA22920.1 - 0.013 15.1 0.1 0.024 14.3 0.0 1.5 1 1 0 1 1 1 0 UEV domain DUF4413 PF14372.1 ESA22921.1 - 0.04 13.8 0.1 0.22 11.5 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4413) DUF1433 PF07252.6 ESA22923.1 - 0.013 15.7 1.6 0.94 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1433) F-box-like PF12937.2 ESA22924.1 - 3.6e-05 23.3 4.4 3.6e-05 23.3 3.0 2.0 2 1 0 2 2 2 1 F-box-like ASD1 PF08688.5 ESA22926.1 - 0.017 14.8 0.9 0.021 14.6 0.6 1.0 1 0 0 1 1 1 0 Apx/Shroom domain ASD1 adh_short PF00106.20 ESA22928.1 - 3.2e-05 23.9 0.0 0.0017 18.3 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase Polysacc_synt_2 PF02719.10 ESA22928.1 - 0.032 13.1 0.1 0.16 10.8 0.0 1.9 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.20 ESA22929.1 - 1.2e-11 44.8 0.0 1.6e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA22929.1 - 0.01 15.5 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 KR domain IF4E PF01652.13 ESA22930.1 - 1.2e-19 70.4 0.1 1.4e-19 70.1 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Cytochrom_C PF00034.16 ESA22931.1 - 3.6e-12 46.9 0.1 5.7e-12 46.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 ESA22931.1 - 1.7e-09 37.6 1.6 7.2e-09 35.6 1.1 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 ESA22931.1 - 0.00046 19.6 2.1 0.004 16.6 1.5 2.1 1 1 0 1 1 1 1 Cytochrome c-550 domain Cytochrom_C1 PF02167.10 ESA22931.1 - 0.028 14.0 0.1 0.033 13.8 0.0 1.4 1 1 0 1 1 1 0 Cytochrome C1 family Cytochrome-c551 PF10643.4 ESA22931.1 - 0.066 12.5 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 Haem_bd PF14376.1 ESA22931.1 - 0.084 12.5 0.1 0.17 11.5 0.0 1.5 2 0 0 2 2 2 0 Haem-binding domain DUF1014 PF06244.7 ESA22932.1 - 5.8e-24 84.6 24.0 2.3e-22 79.4 16.7 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1014) DUF1675 PF07897.6 ESA22932.1 - 1.4 8.7 13.8 1.8 8.3 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) V_ATPase_I PF01496.14 ESA22932.1 - 3.9 5.2 10.6 4.6 4.9 7.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CAML PF14963.1 ESA22932.1 - 9.2 5.5 8.4 14 4.9 5.8 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Voltage_CLC PF00654.15 ESA22933.1 - 0.046 12.7 0.2 0.047 12.7 0.1 1.0 1 0 0 1 1 1 0 Voltage gated chloride channel Nairovirus_M PF07948.6 ESA22933.1 - 0.11 10.5 0.8 0.11 10.6 0.6 1.0 1 0 0 1 1 1 0 Nairovirus M polyprotein-like DUF1049 PF06305.6 ESA22933.1 - 0.12 11.8 0.3 0.16 11.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Spc97_Spc98 PF04130.8 ESA22934.1 - 3.4e-79 266.5 3.6 5.5e-79 265.9 0.1 2.7 2 1 0 2 2 2 1 Spc97 / Spc98 family DUF1640 PF07798.6 ESA22934.1 - 0.038 14.0 8.0 0.12 12.4 5.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) TrwC PF08751.6 ESA22934.1 - 0.13 11.6 5.5 0.22 10.9 3.8 1.2 1 0 0 1 1 1 0 TrwC relaxase An_peroxidase PF03098.10 ESA22935.1 - 5.1e-92 308.9 0.0 6.4e-92 308.6 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase DOMON PF03351.12 ESA22935.1 - 1.8e-13 50.5 3.1 4.6e-13 49.1 1.9 2.0 1 1 0 1 1 1 1 DOMON domain DUF2427 PF10348.4 ESA22935.1 - 0.18 11.3 1.5 0.32 10.5 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) An_peroxidase PF03098.10 ESA22936.1 - 5.6e-43 147.1 0.0 7e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Nitrophorin PF02087.10 ESA22937.1 - 0.082 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Nitrophorin Microtub_bind PF13931.1 ESA22937.1 - 0.35 10.9 1.7 0.68 10.0 0.1 1.9 2 0 0 2 2 2 0 Kinesin-associated microtubule-binding HMG_box PF00505.14 ESA22939.1 - 2.8e-08 33.9 2.9 1.3e-07 31.8 0.5 2.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA22939.1 - 0.00027 21.2 0.8 0.00027 21.2 0.6 1.9 2 0 0 2 2 2 1 HMG-box domain DUF2829 PF11195.3 ESA22939.1 - 0.25 11.8 1.1 37 4.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2829) Kei1 PF08552.6 ESA22941.1 - 0.3 10.7 25.3 0.26 10.9 1.5 2.3 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 ABC2_membrane_5 PF13346.1 ESA22942.1 - 0.32 10.2 21.6 0.44 9.7 14.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein MARVEL PF01284.18 ESA22942.1 - 3.1 7.5 14.9 0.055 13.2 1.0 2.3 1 1 1 2 2 2 0 Membrane-associating domain MCM PF00493.18 ESA22943.1 - 4.7e-134 446.3 0.3 4.7e-134 446.3 0.2 1.5 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 ESA22943.1 - 1.1e-15 58.1 1.6 4.7e-15 56.1 1.1 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 ESA22943.1 - 7.7e-07 28.4 0.0 1.8e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 ESA22943.1 - 0.0033 16.9 0.0 0.0069 15.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 ESA22943.1 - 0.0054 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 ESA22943.1 - 0.02 14.5 0.0 0.051 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Tnp_zf-ribbon_2 PF13842.1 ESA22943.1 - 0.41 11.0 2.1 1.3 9.4 1.4 1.8 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon SNARE PF05739.14 ESA22944.1 - 1e-10 41.1 4.9 1.6e-10 40.5 0.8 2.4 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 ESA22944.1 - 1.5e-10 41.1 15.5 3.6e-10 39.9 3.8 2.3 2 0 0 2 2 2 2 Syntaxin Shisa PF13908.1 ESA22944.1 - 0.00057 20.1 1.5 0.00067 19.8 0.2 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator ODV-E18 PF10717.4 ESA22944.1 - 0.0044 16.4 0.1 0.009 15.4 0.0 1.5 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Syntaxin_2 PF14523.1 ESA22944.1 - 0.008 16.1 12.3 0.02 14.9 4.6 2.4 2 1 0 2 2 2 1 Syntaxin-like protein V-SNARE PF05008.10 ESA22944.1 - 0.012 15.7 0.7 0.012 15.7 0.5 2.9 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF3671 PF12420.3 ESA22944.1 - 0.017 15.1 0.0 0.042 13.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF912 PF06024.7 ESA22944.1 - 0.021 14.8 0.0 0.077 13.0 0.0 2.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) T2SG PF08334.6 ESA22944.1 - 0.2 11.4 2.4 0.22 11.2 0.3 2.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein G DUF948 PF06103.6 ESA22944.1 - 0.8 9.6 11.7 2.2 8.1 0.6 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) ISG65-75 PF11727.3 ESA22944.1 - 0.87 8.5 10.7 0.21 10.6 1.1 2.3 1 1 1 2 2 2 0 Invariant surface glycoprotein Muted PF14942.1 ESA22944.1 - 1.4 8.7 12.8 0.35 10.7 4.2 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Laminin_II PF06009.7 ESA22944.1 - 2.2 8.0 9.4 1.5 8.5 0.9 2.5 2 1 0 2 2 2 0 Laminin Domain II DUF2203 PF09969.4 ESA22944.1 - 2.3 8.4 11.0 0.34 11.1 0.7 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4094 PF13334.1 ESA22944.1 - 3 8.2 8.9 0.36 11.2 0.4 3.4 3 2 0 3 3 3 0 Domain of unknown function (DUF4094) COMP PF11598.3 ESA22944.1 - 4.3 7.4 7.0 31 4.7 1.0 3.3 2 1 0 2 2 2 0 Cartilage oligomeric matrix protein Prominin PF05478.6 ESA22944.1 - 8.2 3.8 10.5 7.3 3.9 6.4 1.5 1 1 0 1 1 1 0 Prominin DUF1664 PF07889.7 ESA22944.1 - 9.3 6.0 8.9 0.91 9.3 1.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) GTP_cyclohydroI PF01227.17 ESA22946.1 - 0.075 12.3 0.1 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase I CbiA PF01656.18 ESA22947.1 - 1.2e-17 63.9 0.5 1.9e-17 63.3 0.3 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 ESA22947.1 - 9.1e-11 41.9 0.1 1.4e-09 38.0 0.1 2.4 2 1 0 2 2 2 1 AAA domain VirC1 PF07015.6 ESA22947.1 - 3.5e-10 39.3 0.1 0.00049 19.2 0.0 2.2 1 1 1 2 2 2 2 VirC1 protein MipZ PF09140.6 ESA22947.1 - 1.3e-09 37.5 1.8 3.1e-08 33.0 1.2 2.2 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 ESA22947.1 - 7.7e-08 31.7 0.7 2.2e-06 26.9 0.5 2.6 1 1 0 1 1 1 1 Anion-transporting ATPase SRP54 PF00448.17 ESA22947.1 - 2.2e-06 27.2 0.4 0.0033 16.9 0.0 2.4 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain ArgK PF03308.11 ESA22947.1 - 0.00066 18.5 0.4 0.0029 16.4 0.0 2.0 1 1 0 2 2 2 1 ArgK protein Fer4_NifH PF00142.13 ESA22947.1 - 0.00076 18.7 2.2 0.004 16.3 1.5 2.2 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Acyl_transf_2 PF02273.10 ESA22947.1 - 0.0015 17.6 1.0 0.0018 17.3 0.7 1.4 1 1 0 1 1 1 1 Acyl transferase AAA_25 PF13481.1 ESA22947.1 - 0.0028 17.1 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF91 PF01939.11 ESA22947.1 - 0.0071 15.5 0.1 0.01 14.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF91 Pkinase PF00069.20 ESA22948.1 - 5.5e-26 91.2 1.3 8e-26 90.7 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA22948.1 - 2.8e-23 82.2 0.0 3.8e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4451 PF14616.1 ESA22948.1 - 0.0025 17.5 1.8 0.0046 16.7 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Kdo PF06293.9 ESA22948.1 - 0.072 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.16 ESA22949.1 - 1.4e-37 129.0 0.0 1.6e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF4419 PF14388.1 ESA22950.1 - 6.1e-59 199.6 0.2 9.9e-59 198.9 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4419) FANCF PF11107.3 ESA22953.1 - 0.17 11.1 0.5 0.28 10.4 0.1 1.5 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) L51_S25_CI-B8 PF05047.11 ESA22954.1 - 5.4e-11 42.0 0.9 9.8e-11 41.2 0.6 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Glyoxalase_4 PF13669.1 ESA22955.1 - 6.2e-21 74.4 0.0 7.2e-21 74.2 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.20 ESA22955.1 - 1.3e-11 44.5 0.0 1.5e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 ESA22955.1 - 1.1e-09 38.8 0.0 1.2e-09 38.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.1 ESA22955.1 - 1e-06 28.7 0.0 1.2e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain E1-E2_ATPase PF00122.15 ESA22956.1 - 1.1e-75 253.5 1.1 1.1e-75 253.5 0.8 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 ESA22956.1 - 2e-44 151.2 5.0 2e-44 151.2 3.4 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 ESA22956.1 - 1.2e-31 110.7 0.1 3e-31 109.5 0.1 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA22956.1 - 1.1e-16 60.0 0.0 3.2e-16 58.5 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_like2 PF13246.1 ESA22956.1 - 2.6e-16 59.3 0.1 7.1e-16 57.9 0.0 1.8 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 ESA22956.1 - 3.9e-16 59.7 0.0 8.5e-16 58.6 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA22956.1 - 2.9e-07 30.3 2.9 0.0018 17.8 0.5 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 ESA22956.1 - 0.072 13.3 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Med23 PF11573.3 ESA22957.1 - 2.1e-59 201.0 14.3 4.3e-54 183.4 4.6 2.0 2 0 0 2 2 2 2 Mediator complex subunit 23 RecO_N_2 PF13114.1 ESA22957.1 - 0.16 11.6 1.2 0.32 10.7 0.1 2.1 2 0 0 2 2 2 0 RecO N terminal Med23 PF11573.3 ESA22958.1 - 8.3e-08 30.0 0.0 9.1e-08 29.9 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 HhH-GPD PF00730.20 ESA22958.1 - 0.15 12.3 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein PRMT5 PF05185.11 ESA22959.1 - 1.5e-179 597.6 2.5 1.9e-179 597.3 1.8 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.11 ESA22959.1 - 0.00053 19.6 0.0 0.00096 18.8 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.1 ESA22959.1 - 0.0046 16.5 0.0 0.0088 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF3567 PF12091.3 ESA22959.1 - 0.082 12.8 0.1 0.43 10.5 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3567) F_bP_aldolase PF01116.15 ESA22962.1 - 4.4e-101 337.7 0.0 5e-101 337.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II PIF1 PF05970.9 ESA22963.1 - 1.1e-09 37.8 2.3 0.00034 19.6 0.6 2.7 1 1 0 2 2 2 2 PIF1-like helicase EF_assoc_1 PF08355.7 ESA22964.1 - 0.085 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 EF hand associated Alpha_adaptin_C PF02296.11 ESA22968.1 - 0.1 12.5 0.1 0.66 9.9 0.1 2.0 1 1 1 2 2 2 0 Alpha adaptin AP2, C-terminal domain HTH_32 PF13565.1 ESA22969.1 - 7.1e-08 33.1 0.1 8.1e-08 32.9 0.0 1.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.1 ESA22969.1 - 4.3e-05 23.6 0.0 6.1e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.1 ESA22969.1 - 0.00011 22.1 0.0 0.001 19.0 0.0 2.1 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.13 ESA22969.1 - 0.0004 20.3 0.2 0.0017 18.3 0.0 1.8 2 0 0 2 2 2 1 Transposase HTH_23 PF13384.1 ESA22969.1 - 0.0021 17.6 0.0 0.033 13.8 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.1 ESA22970.1 - 3.6e-07 30.8 0.0 4.2e-07 30.6 0.0 1.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 ESA22970.1 - 7.8e-05 22.5 0.0 0.00077 19.4 0.0 2.1 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 ESA22970.1 - 0.0003 20.9 0.0 0.00043 20.3 0.0 1.3 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA22970.1 - 0.00062 19.3 0.0 0.0096 15.5 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.13 ESA22970.1 - 0.011 15.8 0.1 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 Transposase UPF0223 PF05256.7 ESA22971.1 - 0.024 14.7 0.1 0.027 14.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0223) DUF2421 PF10334.4 ESA22971.1 - 0.11 12.0 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2421) MIT PF04212.13 ESA22972.1 - 5.1e-06 26.2 0.4 1.2e-05 25.1 0.3 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pkinase_Tyr PF07714.12 ESA22977.1 - 1.5e-51 174.9 0.0 1.8e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22977.1 - 3.2e-48 164.1 0.3 4.1e-48 163.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA22977.1 - 0.002 17.5 0.7 0.0031 16.8 0.5 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 ESA22977.1 - 0.037 13.1 0.1 0.053 12.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA22977.1 - 0.039 13.6 0.0 0.1 12.3 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA22978.1 - 9.6e-40 136.2 0.0 1.3e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22978.1 - 3.3e-37 128.0 0.9 7.6e-37 126.8 0.6 1.6 1 1 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA22978.1 - 0.041 13.4 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 BCS1 N terminal Rubis-subs-bind PF09273.6 ESA22981.1 - 0.016 15.1 0.3 1.3 8.9 0.0 2.4 1 1 1 2 2 2 0 Rubisco LSMT substrate-binding nsp7 PF08716.5 ESA22981.1 - 0.027 14.8 0.1 0.061 13.7 0.1 1.5 1 0 0 1 1 1 0 nsp7 replicase DUF4208 PF13907.1 ESA22981.1 - 0.039 14.1 3.3 0.72 10.1 0.1 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4208) DUF4485 PF14846.1 ESA22981.1 - 0.12 12.0 0.3 0.12 12.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) DUF4116 PF13475.1 ESA22982.1 - 9.3 5.8 9.8 0.81 9.2 0.1 3.4 4 1 0 4 4 4 0 Domain of unknown function (DUF4116) Ada3 PF10198.4 ESA22983.1 - 0.015 15.0 0.1 0.017 14.8 0.1 1.1 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Pkinase_Tyr PF07714.12 ESA22985.1 - 2.1e-36 125.3 0.0 2.7e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA22985.1 - 1.9e-34 119.0 0.0 3.1e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA22985.1 - 0.089 12.5 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1395 PF07160.7 ESA22987.1 - 2.1e-32 112.6 3.4 2.5e-32 112.3 2.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1395) DASH_Duo1 PF08651.5 ESA22987.1 - 0.012 15.1 2.5 0.39 10.3 0.2 2.8 2 1 1 3 3 3 0 DASH complex subunit Duo1 Toxin_trans PF07952.7 ESA22987.1 - 0.051 12.4 3.2 0.057 12.3 1.4 1.6 2 0 0 2 2 2 0 Clostridium neurotoxin, Translocation domain KIP1 PF07765.7 ESA22987.1 - 0.072 12.9 0.2 0.072 12.9 0.1 2.2 3 0 0 3 3 3 0 KIP1-like protein ALMT PF11744.3 ESA22987.1 - 0.092 11.3 0.9 0.37 9.4 0.1 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter TipAS PF07739.8 ESA22987.1 - 0.17 12.2 1.6 0.31 11.3 0.1 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain NPV_P10 PF05531.7 ESA22987.1 - 0.17 12.1 1.4 1.2 9.4 0.0 2.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Sec5 PF15469.1 ESA22987.1 - 0.23 11.1 5.9 0.43 10.2 0.3 2.2 2 0 0 2 2 2 0 Exocyst complex component Sec5 TMF_TATA_bd PF12325.3 ESA22987.1 - 0.35 10.6 6.7 0.097 12.3 1.4 2.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding ERM PF00769.14 ESA22987.1 - 0.48 9.9 8.4 2.7 7.4 1.3 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF972 PF06156.8 ESA22987.1 - 1.3 9.4 6.9 0.29 11.4 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF972) Aminotran_1_2 PF00155.16 ESA22988.1 - 7.1e-79 265.3 0.1 1.1e-78 264.7 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 ESA22988.1 - 1.7e-06 27.0 0.0 1.2e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 ESA22988.1 - 1.7e-05 23.3 0.0 2.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 ESA22988.1 - 0.042 12.8 0.1 0.13 11.3 0.1 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF1140 PF06600.6 ESA22990.1 - 0.0088 16.1 0.1 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1140) PLU-1 PF08429.6 ESA22990.1 - 0.076 11.8 0.0 0.076 11.8 0.0 1.0 1 0 0 1 1 1 0 PLU-1-like protein DUF883 PF05957.8 ESA22990.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MSV199 PF10553.4 ESA22991.1 - 0.074 12.9 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 MSV199 domain TerB-N PF13208.1 ESA22992.1 - 0.047 13.1 0.5 0.052 12.9 0.3 1.1 1 0 0 1 1 1 0 TerB-N zf-H2C2_2 PF13465.1 ESA22993.1 - 5.7e-27 92.6 20.3 6.2e-08 32.5 1.2 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 ESA22993.1 - 1.6e-24 84.7 25.0 6.2e-06 26.2 2.4 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA22993.1 - 6.9e-17 60.4 25.7 4e-05 23.6 1.8 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 ESA22993.1 - 2.6e-07 30.5 8.4 0.67 10.1 0.1 4.4 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 ESA22993.1 - 4.2e-05 23.2 12.9 0.17 11.8 0.5 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-TRAF PF02176.13 ESA22993.1 - 8.9e-05 22.7 8.5 0.028 14.8 0.3 2.9 1 1 2 3 3 3 3 TRAF-type zinc finger zf-met PF12874.2 ESA22993.1 - 0.0038 17.3 10.1 1.5 9.1 0.1 4.5 4 0 0 4 4 4 1 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.5 ESA22993.1 - 0.013 15.4 6.5 7.7 6.5 0.1 3.8 4 0 0 4 4 4 0 Zinc ribbon domain BolA PF01722.13 ESA22993.1 - 0.016 15.1 0.2 7.8 6.5 0.0 2.9 3 0 0 3 3 3 0 BolA-like protein Ogr_Delta PF04606.7 ESA22993.1 - 0.046 13.3 10.9 0.81 9.3 0.9 4.0 1 1 3 4 4 4 0 Ogr/Delta-like zinc finger CHORD PF04968.7 ESA22993.1 - 0.22 11.7 14.6 2.2 8.5 0.3 4.0 1 1 3 4 4 4 0 CHORD CCAP PF11105.3 ESA22993.1 - 0.27 10.9 6.7 2.8 7.6 0.7 2.9 1 1 2 3 3 3 0 Arthropod cardioacceleratory peptide 2a zf-CGNR PF11706.3 ESA22993.1 - 1.7 8.2 12.4 3.6 7.1 2.3 4.0 3 1 0 3 3 3 0 CGNR zinc finger zf-CCHC PF00098.18 ESA22994.1 - 1.9e-07 30.6 0.4 3.3e-07 29.9 0.3 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 ESA22994.1 - 0.0017 18.3 0.0 0.0017 18.3 0.0 2.7 3 1 0 3 3 3 1 Retrotransposon gag protein Nic96 PF04097.9 ESA22994.1 - 0.029 12.5 0.1 0.041 12.0 0.1 1.2 1 0 0 1 1 1 0 Nup93/Nic96 XPG_I_2 PF12813.2 ESA22994.1 - 0.085 12.3 0.3 0.16 11.4 0.1 1.5 1 1 1 2 2 2 0 XPG domain containing VWA_2 PF13519.1 ESA22994.1 - 0.15 12.1 1.2 0.81 9.7 0.6 2.4 1 1 1 2 2 2 0 von Willebrand factor type A domain FlxA PF14282.1 ESA22994.1 - 0.81 9.6 6.2 3.1 7.8 0.4 2.6 2 0 0 2 2 2 0 FlxA-like protein CHASE3 PF05227.8 ESA22994.1 - 1 9.0 5.9 0.72 9.5 0.2 2.7 3 0 0 3 3 3 0 CHASE3 domain TGF_beta_GS PF08515.7 ESA22996.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Exo_endo_phos PF03372.18 ESA22997.1 - 8.3e-07 29.1 0.0 1.9e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Methyltransf_11 PF08241.7 ESA22999.1 - 6.5e-07 29.7 0.0 4.8e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA22999.1 - 2.2e-05 24.2 0.0 0.00033 20.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA22999.1 - 0.0032 17.0 0.0 0.016 14.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA22999.1 - 0.01 16.4 0.0 0.022 15.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESA22999.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain p450 PF00067.17 ESA23002.1 - 1.9e-41 142.0 0.0 2.1e-41 141.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sel1 PF08238.7 ESA23003.1 - 4.4e-30 103.4 10.7 1.4e-11 44.6 0.1 3.4 3 1 1 4 4 3 3 Sel1 repeat MIT PF04212.13 ESA23003.1 - 1.8e-06 27.6 7.0 0.049 13.5 0.4 3.4 2 1 1 3 3 3 3 MIT (microtubule interacting and transport) domain Surfac_D-trimer PF09006.6 ESA23003.1 - 0.0016 18.0 0.2 9.9 5.9 0.0 3.2 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation zinc-ribbons_6 PF07191.7 ESA23003.1 - 0.006 16.3 1.2 0.0098 15.6 0.8 1.3 1 0 0 1 1 1 1 zinc-ribbons TPR_20 PF14561.1 ESA23003.1 - 0.025 14.6 0.8 1.8 8.7 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3087 PF11286.3 ESA23003.1 - 0.031 13.4 1.5 0.52 9.5 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3087) TPR_17 PF13431.1 ESA23003.1 - 0.06 13.5 6.6 0.16 12.2 0.3 3.3 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA23003.1 - 0.27 11.2 4.5 3.4 7.7 0.5 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 ESA23003.1 - 0.34 10.8 9.2 1.8 8.5 2.4 3.2 2 2 0 2 2 2 0 Tetratricopeptide repeat DUF4071 PF13281.1 ESA23003.1 - 0.63 8.8 7.2 2.7 6.7 0.3 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4071) TPR_2 PF07719.12 ESA23003.1 - 0.65 10.0 15.0 3.2 7.9 0.4 4.7 3 2 1 4 4 4 0 Tetratricopeptide repeat Rapamycin_bind PF08771.6 ESA23003.1 - 1.1 9.3 6.6 13 5.9 0.1 3.3 1 1 2 4 4 4 0 Rapamycin binding domain Ubiq-assoc PF09145.5 ESA23003.1 - 1.3 8.9 6.5 5.2 7.0 0.3 3.7 3 1 1 4 4 4 0 Ubiquitin-associated Spot_14 PF07084.7 ESA23003.1 - 1.5 8.6 5.8 37 4.1 1.7 3.0 1 1 2 3 3 3 0 Thyroid hormone-inducible hepatic protein Spot 14 TPR_1 PF00515.23 ESA23003.1 - 9.2 6.0 15.3 6.5 6.5 0.6 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-BED PF02892.10 ESA23005.1 - 1.1e-07 31.4 4.1 1.7e-07 30.8 2.9 1.3 1 0 0 1 1 1 1 BED zinc finger DUF2058 PF09831.4 ESA23005.1 - 0.11 12.4 16.8 0.14 12.0 11.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) PLRV_ORF5 PF01690.12 ESA23005.1 - 1.5 7.8 15.3 1.6 7.8 10.6 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Merozoite_SPAM PF07133.6 ESA23005.1 - 2.2 8.1 43.1 3.5 7.4 29.9 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF2413 PF10310.4 ESA23005.1 - 3.2 6.4 21.9 3.8 6.2 15.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Daxx PF03344.10 ESA23005.1 - 5.6 5.3 38.2 6.9 5.0 26.5 1.0 1 0 0 1 1 1 0 Daxx Family DUF262 PF03235.9 ESA23005.1 - 5.8 6.8 12.8 6.7 6.6 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 Caldesmon PF02029.10 ESA23005.1 - 6.5 5.0 33.7 8.7 4.6 23.4 1.1 1 0 0 1 1 1 0 Caldesmon CDC45 PF02724.9 ESA23005.1 - 6.6 4.6 28.4 7.9 4.3 19.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4045 PF13254.1 ESA23005.1 - 6.8 5.8 14.9 7.5 5.7 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Peptidase_S3 PF00944.14 ESA23008.1 - 0.03 13.7 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 Alphavirus core protein Trypsin_2 PF13365.1 ESA23008.1 - 0.058 13.3 0.0 0.24 11.4 0.0 2.0 1 1 0 1 1 1 0 Trypsin-like peptidase domain Peptidase_S32 PF05579.8 ESA23008.1 - 0.12 11.3 0.0 0.25 10.2 0.0 1.4 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Trypsin PF00089.21 ESA23008.1 - 0.16 11.5 0.0 0.37 10.3 0.0 1.6 2 0 0 2 2 2 0 Trypsin KilA-N PF04383.8 ESA23009.1 - 0.11 12.1 0.9 0.3 10.7 0.5 1.8 2 0 0 2 2 2 0 KilA-N domain DDE_3 PF13358.1 ESA23010.1 - 0.037 13.7 0.0 0.37 10.5 0.0 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease CENP-P PF13096.1 ESA23011.1 - 0.059 12.6 0.2 0.06 12.6 0.1 1.1 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P CDRN PF05174.7 ESA23011.1 - 0.11 11.9 0.2 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich D. radiodurans N terminus CDRN PF05174.7 ESA23013.1 - 0.0034 16.7 0.1 0.0037 16.6 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich D. radiodurans N terminus Pkinase_Tyr PF07714.12 ESA23014.1 - 9.4e-23 80.5 0.4 2.9e-17 62.6 0.1 4.7 5 0 0 5 5 5 2 Protein tyrosine kinase Pkinase PF00069.20 ESA23014.1 - 1e-13 51.0 4.6 1e-13 51.0 3.2 3.2 5 1 0 5 5 5 1 Protein kinase domain BCS1_N PF08740.6 ESA23014.1 - 4.8e-09 36.0 0.2 0.18 11.4 0.0 4.7 4 0 0 4 4 4 3 BCS1 N terminal DUF4585 PF15232.1 ESA23014.1 - 0.033 14.0 0.0 33 4.4 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4585) SseB_C PF14581.1 ESA23014.1 - 0.079 12.8 0.2 8 6.3 0.0 3.8 5 0 0 5 5 5 0 SseB protein C-terminal domain APH PF01636.18 ESA23014.1 - 0.19 11.3 0.1 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PGM_PMM_I PF02878.11 ESA23017.1 - 6.5e-19 67.7 0.2 2.9e-08 33.2 0.0 2.8 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 ESA23017.1 - 2.2e-13 50.4 0.1 1.5e-12 47.7 0.0 2.5 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 ESA23017.1 - 1.5e-12 47.3 0.6 4.9e-12 45.6 0.2 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.11 ESA23017.1 - 0.15 12.1 1.0 0.34 10.9 0.1 2.1 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Exo_endo_phos PF03372.18 ESA23018.1 - 1.2e-08 35.2 0.0 1.5e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Meth_synt_2 PF01717.13 ESA23019.1 - 4.1e-151 502.5 0.0 1.2e-143 477.9 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 ESA23019.1 - 2e-126 421.5 0.0 5.9e-111 370.6 0.0 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain DUF4377 PF14302.1 ESA23021.1 - 0.15 11.9 0.0 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4377) zf-RVT PF13966.1 ESA23022.1 - 0.00018 21.7 0.1 0.00018 21.7 0.0 2.4 3 0 0 3 3 3 1 zinc-binding in reverse transcriptase RNase_H PF00075.19 ESA23022.1 - 0.00098 19.4 0.0 0.0022 18.3 0.0 1.5 1 0 0 1 1 1 1 RNase H F-box-like PF12937.2 ESA23023.1 - 0.00065 19.3 1.6 0.00065 19.3 1.1 2.6 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.28 ESA23023.1 - 0.019 14.9 6.0 43 4.7 0.3 6.5 5 2 1 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.1 ESA23023.1 - 0.064 13.3 10.9 5.4 7.3 0.1 5.8 7 0 0 7 7 7 0 Leucine Rich repeat ANTH PF07651.11 ESA23023.1 - 0.16 10.6 0.4 0.3 9.7 0.0 1.6 2 0 0 2 2 2 0 ANTH domain Med11 PF10280.4 ESA23024.1 - 2.6e-07 30.6 0.6 5.6e-07 29.6 0.4 1.7 1 1 0 1 1 1 1 Mediator complex protein FYRN PF05964.9 ESA23026.1 - 1.8e-11 43.3 0.0 3.4e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus CENP-F_leu_zip PF10473.4 ESA23026.1 - 0.0021 17.9 7.2 0.0034 17.2 5.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.10 ESA23026.1 - 0.0029 17.0 5.1 0.0052 16.2 3.5 1.4 1 0 0 1 1 1 1 Septum formation initiator DASH_Spc19 PF08287.6 ESA23026.1 - 0.0066 16.0 11.0 0.013 15.1 7.1 1.8 1 1 1 2 2 2 1 Spc19 Vfa1 PF08432.5 ESA23026.1 - 0.0094 15.9 9.6 0.0094 15.9 6.7 1.4 2 0 0 2 2 1 1 AAA-ATPase Vps4-associated protein 1 Laminin_II PF06009.7 ESA23026.1 - 0.013 15.2 3.3 0.023 14.4 2.3 1.4 1 0 0 1 1 1 0 Laminin Domain II DUF3584 PF12128.3 ESA23026.1 - 0.018 12.3 5.3 0.02 12.2 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BRE1 PF08647.6 ESA23026.1 - 0.02 14.8 2.5 0.02 14.8 1.7 1.8 2 0 0 2 2 1 0 BRE1 E3 ubiquitin ligase GAS PF13851.1 ESA23026.1 - 0.021 14.0 5.9 0.034 13.3 4.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding V_ATPase_I PF01496.14 ESA23026.1 - 0.022 12.6 1.7 0.022 12.6 1.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESA23026.1 - 0.028 13.4 4.5 0.041 12.9 3.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 GrpE PF01025.14 ESA23026.1 - 0.031 13.8 3.2 0.05 13.1 2.2 1.3 1 0 0 1 1 1 0 GrpE IncA PF04156.9 ESA23026.1 - 0.032 13.8 7.8 0.044 13.3 5.4 1.1 1 0 0 1 1 1 0 IncA protein TBPIP PF07106.8 ESA23026.1 - 0.034 13.6 5.3 0.049 13.1 3.7 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF342 PF03961.8 ESA23026.1 - 0.051 11.9 2.3 0.065 11.6 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IFT57 PF10498.4 ESA23026.1 - 0.068 11.8 4.2 0.1 11.3 2.9 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF3450 PF11932.3 ESA23026.1 - 0.071 12.3 3.9 0.13 11.5 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4279 PF14106.1 ESA23026.1 - 0.083 12.7 0.3 0.15 11.9 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Fmp27_WPPW PF10359.4 ESA23026.1 - 0.091 11.1 6.8 0.11 10.8 4.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Med3 PF11593.3 ESA23026.1 - 0.094 11.9 4.5 0.13 11.5 3.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CHD5 PF04420.9 ESA23026.1 - 0.099 12.3 2.4 0.17 11.5 1.7 1.4 1 0 0 1 1 1 0 CHD5-like protein DUF972 PF06156.8 ESA23026.1 - 0.13 12.6 4.0 0.24 11.7 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Phage_GP20 PF06810.6 ESA23026.1 - 0.16 11.4 7.5 0.31 10.4 5.2 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 TMF_DNA_bd PF12329.3 ESA23026.1 - 0.2 11.4 10.7 0.17 11.7 6.0 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding bZIP_2 PF07716.10 ESA23026.1 - 0.21 11.4 8.1 0.77 9.6 0.5 2.5 1 1 1 2 2 2 0 Basic region leucine zipper OmpH PF03938.9 ESA23026.1 - 0.22 11.4 3.0 0.33 10.8 2.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HemX PF04375.9 ESA23026.1 - 0.24 9.9 3.9 0.33 9.4 2.4 1.5 2 0 0 2 2 2 0 HemX CENP-Q PF13094.1 ESA23026.1 - 0.3 11.1 8.6 0.46 10.4 6.0 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.7 ESA23026.1 - 0.34 11.3 4.2 1.7 9.0 2.9 2.1 1 1 1 2 2 2 0 SlyX HAUS6_N PF14661.1 ESA23026.1 - 0.42 9.9 4.3 0.77 9.0 3.0 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Mnd1 PF03962.10 ESA23026.1 - 0.51 9.9 7.5 0.78 9.3 5.2 1.3 1 0 0 1 1 1 0 Mnd1 family DUF4446 PF14584.1 ESA23026.1 - 0.74 9.6 3.4 1.3 8.8 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) bZIP_1 PF00170.16 ESA23026.1 - 0.75 9.7 12.2 0.097 12.6 5.2 1.9 2 0 0 2 2 2 0 bZIP transcription factor DUF4482 PF14818.1 ESA23026.1 - 0.76 10.4 11.2 1.1 9.8 7.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) DUF4140 PF13600.1 ESA23026.1 - 0.83 10.1 4.6 0.19 12.2 0.7 1.8 2 0 0 2 2 1 0 N-terminal domain of unknown function (DUF4140) CASP_C PF08172.7 ESA23026.1 - 0.84 8.6 10.2 0.88 8.5 6.5 1.4 1 1 0 1 1 1 0 CASP C terminal HALZ PF02183.13 ESA23026.1 - 1.1 9.0 8.9 0.14 11.8 1.7 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper Tho2 PF11262.3 ESA23026.1 - 1.1 8.2 4.5 1.6 7.6 3.1 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LCD1 PF09798.4 ESA23026.1 - 1.1 7.1 7.0 1.5 6.7 4.8 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein TMPIT PF07851.8 ESA23026.1 - 1.2 8.1 5.1 1.6 7.7 3.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein Uds1 PF15456.1 ESA23026.1 - 2.6 8.0 12.3 0.18 11.7 2.2 2.3 1 1 1 2 2 2 0 Up-regulated During Septation DUF465 PF04325.8 ESA23026.1 - 4.3 7.1 10.6 49 3.7 7.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF465) DUF2522 PF10747.4 ESA23028.1 - 0.016 15.2 0.2 0.021 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2522) DUF4037 PF13228.1 ESA23028.1 - 0.067 13.4 0.0 0.17 12.1 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4037) BTB_2 PF02214.17 ESA23030.1 - 1.9e-20 72.8 0.3 8.4e-20 70.7 0.2 2.0 1 1 0 1 1 1 1 BTB/POZ domain DUF619 PF04768.8 ESA23030.1 - 0.061 12.7 0.4 0.14 11.5 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF619) Pkinase PF00069.20 ESA23031.1 - 2.9e-24 85.6 0.1 3.4e-24 85.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23031.1 - 9.3e-23 80.6 0.0 1.2e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA23031.1 - 0.0047 15.9 0.0 2.2 7.1 0.0 2.1 1 1 1 2 2 2 2 Kinase-like zf-CCHC PF00098.18 ESA23032.1 - 9.6e-11 41.0 13.9 9.1e-06 25.3 3.3 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.1 ESA23032.1 - 0.0013 18.3 10.9 0.0052 16.4 1.2 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 ESA23032.1 - 0.029 14.0 9.1 0.54 9.9 0.6 2.6 2 0 0 2 2 2 0 Zinc knuckle Stig1 PF04885.8 ESA23032.1 - 0.09 12.9 9.0 1.1 9.4 0.7 2.4 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 Thioredoxin_3 PF13192.1 ESA23032.1 - 0.18 11.6 1.6 1.3 8.8 0.1 2.5 2 0 0 2 2 2 0 Thioredoxin domain zf-CCHC_2 PF13696.1 ESA23032.1 - 0.45 10.0 4.4 0.79 9.2 0.3 2.4 2 0 0 2 2 2 0 Zinc knuckle FAM222A PF15258.1 ESA23032.1 - 0.59 9.2 8.2 0.81 8.8 2.0 2.1 2 0 0 2 2 2 0 Protein family of FAM222A Asp_protease_2 PF13650.1 ESA23033.1 - 1e-09 38.7 0.0 1.4e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 ESA23033.1 - 5.8e-06 26.1 0.1 1.1e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.5 ESA23033.1 - 3.3e-05 23.4 0.0 5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.6 ESA23033.1 - 0.00025 20.9 0.0 0.00034 20.5 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA23033.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Peptidase_A2E PF12382.3 ESA23033.1 - 0.041 13.6 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon peptidase PBP1_TM PF14812.1 ESA23033.1 - 0.53 10.6 7.2 0.88 9.9 5.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YL1 PF05764.8 ESA23033.1 - 0.54 9.8 14.8 0.71 9.4 10.3 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Myc_N PF01056.13 ESA23033.1 - 0.76 8.8 8.6 0.96 8.5 5.9 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Nucleoplasmin PF03066.10 ESA23033.1 - 2.3 7.7 10.0 3.8 7.0 6.9 1.3 1 0 0 1 1 1 0 Nucleoplasmin DNA_pol_phi PF04931.8 ESA23033.1 - 3.6 5.2 14.4 4.7 4.8 10.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi XhlA PF10779.4 ESA23035.1 - 0.047 13.6 0.4 0.047 13.6 0.3 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Ins145_P3_rec PF08709.6 ESA23036.1 - 1.8e-08 33.6 0.0 5.4e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.14 ESA23036.1 - 3.6e-05 23.3 0.0 0.14 11.6 0.0 3.0 1 1 2 3 3 3 2 MIR domain MIR PF02815.14 ESA23037.1 - 0.0043 16.6 0.0 0.0092 15.5 0.0 1.7 1 1 0 1 1 1 1 MIR domain DDE_1 PF03184.14 ESA23038.1 - 0.019 14.1 0.2 0.036 13.1 0.0 1.5 2 0 0 2 2 2 0 DDE superfamily endonuclease Ribos_L4_asso_C PF14374.1 ESA23038.1 - 0.058 13.2 0.5 0.48 10.3 0.1 2.1 2 0 0 2 2 2 0 60S ribosomal protein L4 C-terminal domain Alpha_kinase PF02816.13 ESA23039.1 - 1.6e-37 129.0 0.1 3.5e-37 127.8 0.1 1.6 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA23039.1 - 1.1e-06 28.9 0.0 2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA23039.1 - 0.0023 17.6 0.0 0.0055 16.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Alpha_kinase PF02816.13 ESA23041.1 - 9.7e-38 129.7 0.2 2.1e-37 128.6 0.2 1.6 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA23041.1 - 4.3e-05 23.6 0.0 6.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA23041.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain TBPIP PF07106.8 ESA23041.1 - 0.5 9.8 5.6 0.52 9.8 2.3 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) RNA_pol_Rpb2_1 PF04563.10 ESA23042.1 - 4.6e-09 35.5 0.1 5e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_1 PF04563.10 ESA23043.1 - 2.1e-25 88.8 0.2 2.4e-25 88.6 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit DUF708 PF05341.6 ESA23043.1 - 0.054 13.2 0.1 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF708) Ribosomal_S15 PF00312.17 ESA23045.1 - 9.2e-23 79.8 3.1 1.9e-22 78.7 2.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S15 Peptidase_M48 PF01435.13 ESA23047.1 - 2.2e-07 30.7 0.0 4.7e-07 29.6 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M48 DUF955 PF06114.8 ESA23047.1 - 0.027 14.1 0.4 0.087 12.5 0.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF955) Mito_carr PF00153.22 ESA23048.1 - 3.1e-67 222.3 0.9 3e-22 78.1 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.11 ESA23048.1 - 0.012 15.4 0.2 1 9.3 0.0 3.1 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Aldo_ket_red PF00248.16 ESA23052.1 - 2.2e-27 95.6 0.0 2.7e-27 95.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HMG_box PF00505.14 ESA23053.1 - 1.2e-07 31.8 0.5 3.5e-07 30.3 0.0 2.0 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23053.1 - 0.015 15.6 0.1 0.034 14.5 0.0 1.6 1 0 0 1 1 1 0 HMG-box domain MreB_Mbl PF06723.8 ESA23054.1 - 9.4e-06 24.4 0.0 0.053 12.1 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein HSP70 PF00012.15 ESA23054.1 - 3.6e-05 21.9 1.3 0.00018 19.5 0.9 2.1 1 1 0 1 1 1 1 Hsp70 protein MRG PF05712.8 ESA23054.1 - 0.047 12.5 1.3 0.096 11.5 0.9 1.4 1 0 0 1 1 1 0 MRG CCDC155 PF14662.1 ESA23055.1 - 0.00033 20.3 4.6 0.00043 19.9 3.2 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 DivIC PF04977.10 ESA23055.1 - 0.0029 17.0 6.8 0.0029 17.0 4.7 2.2 1 1 1 2 2 2 1 Septum formation initiator ERM PF00769.14 ESA23055.1 - 0.004 16.7 6.3 0.0064 16.0 4.4 1.3 1 1 0 1 1 1 1 Ezrin/radixin/moesin family Myosin_tail_1 PF01576.14 ESA23055.1 - 0.0045 14.7 8.1 0.0059 14.3 5.6 1.1 1 0 0 1 1 1 1 Myosin tail DUF724 PF05266.9 ESA23055.1 - 0.0066 16.0 5.9 0.0097 15.5 4.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) DUF904 PF06005.7 ESA23055.1 - 0.0066 16.7 7.3 0.0066 16.7 5.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF904) TBPIP PF07106.8 ESA23055.1 - 0.018 14.6 8.0 0.029 13.9 5.5 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Fungal_trans_2 PF11951.3 ESA23055.1 - 0.022 13.3 0.2 0.028 13.0 0.1 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain bZIP_1 PF00170.16 ESA23055.1 - 0.032 14.1 6.3 0.032 14.1 4.4 2.5 2 1 1 3 3 2 0 bZIP transcription factor EAP30 PF04157.11 ESA23055.1 - 0.038 13.1 0.4 0.054 12.6 0.3 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Sipho_Gp157 PF05565.6 ESA23055.1 - 0.046 13.3 4.4 0.068 12.7 3.0 1.2 1 0 0 1 1 1 0 Siphovirus Gp157 ADIP PF11559.3 ESA23055.1 - 0.046 13.6 8.8 0.072 12.9 6.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF4413 PF14372.1 ESA23055.1 - 0.049 13.6 0.1 0.087 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DUF972 PF06156.8 ESA23055.1 - 0.049 13.9 7.4 0.062 13.6 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) TMCO5 PF14992.1 ESA23055.1 - 0.06 12.4 7.6 0.088 11.9 5.2 1.2 1 0 0 1 1 1 0 TMCO5 family Leu_zip PF15294.1 ESA23055.1 - 0.079 12.0 8.7 0.12 11.4 6.0 1.2 1 0 0 1 1 1 0 Leucine zipper HAUS6_N PF14661.1 ESA23055.1 - 0.13 11.5 3.0 0.19 11.0 2.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Tropomyosin_1 PF12718.2 ESA23055.1 - 0.14 12.0 12.1 0.31 10.8 8.4 1.5 1 1 0 1 1 1 0 Tropomyosin like V_ATPase_I PF01496.14 ESA23055.1 - 0.16 9.7 1.5 0.18 9.6 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 ESA23055.1 - 0.21 10.5 8.5 0.27 10.2 5.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 U1snRNP70_N PF12220.3 ESA23055.1 - 0.29 11.4 7.1 0.13 12.6 2.7 1.9 1 1 1 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Glyco_tran_28_C PF04101.11 ESA23055.1 - 0.48 10.0 2.6 0.68 9.5 1.8 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain DUF837 PF05769.6 ESA23055.1 - 0.69 9.4 8.5 2.5 7.5 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF837) IncA PF04156.9 ESA23055.1 - 0.78 9.3 6.6 1.2 8.7 4.6 1.2 1 0 0 1 1 1 0 IncA protein AATF-Che1 PF13339.1 ESA23055.1 - 1.1 9.3 8.7 0.67 10.1 3.5 2.0 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor CENP-H PF05837.7 ESA23055.1 - 1.3 9.2 9.5 0.19 11.9 2.6 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) bZIP_2 PF07716.10 ESA23055.1 - 1.8 8.4 13.3 0.27 11.1 4.0 2.4 2 0 0 2 2 2 0 Basic region leucine zipper Microtub_assoc PF07989.6 ESA23055.1 - 2.1 8.2 8.7 1 9.2 1.5 2.2 1 1 0 1 1 1 0 Microtubule associated Shugoshin_N PF07558.6 ESA23055.1 - 4.4 7.1 9.7 7.6 6.3 3.6 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Spc24 PF08286.6 ESA23055.1 - 5 6.8 10.4 0.5 10.0 4.0 1.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4337 PF14235.1 ESA23055.1 - 5.6 6.7 6.2 9.8 5.9 4.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) DUF3484 PF11983.3 ESA23057.1 - 0.11 13.3 0.0 0.21 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) zf-CW PF07496.10 ESA23057.1 - 3.4 7.4 9.5 0.66 9.7 0.2 3.8 4 1 0 4 4 4 0 CW-type Zinc Finger B12D PF06522.6 ESA23058.1 - 0.015 15.0 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Metallothio_Euk PF12749.2 ESA23059.1 - 2.1 8.4 38.8 2.4 8.2 26.9 1.1 1 0 0 1 1 1 0 Eukaryotic metallothionein Metallothio_PEC PF02068.11 ESA23059.1 - 2.8 8.3 36.1 2.7e+02 2.0 25.0 2.5 1 1 0 1 1 1 0 Plant PEC family metallothionein TEBP_beta PF07404.6 ESA23063.1 - 0.017 14.2 0.6 0.02 14.0 0.4 1.0 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) DUF2175 PF09943.4 ESA23063.1 - 1.2 9.1 3.8 6 6.9 2.6 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_5 PF14634.1 ESA23064.1 - 1.2e-09 37.6 11.5 0.00014 21.4 1.3 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-rbx1 PF12678.2 ESA23064.1 - 9.7e-08 32.0 2.7 0.0045 17.0 0.1 2.5 2 0 0 2 2 2 2 RING-H2 zinc finger zf-RING_2 PF13639.1 ESA23064.1 - 9.8e-07 28.5 16.2 0.00026 20.7 1.9 2.8 2 1 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.1 ESA23064.1 - 0.00033 20.5 18.9 0.0085 16.1 2.1 3.2 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA23064.1 - 0.004 16.9 3.9 0.37 10.6 0.2 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 ESA23064.1 - 0.0082 15.7 1.3 0.0082 15.7 0.9 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23064.1 - 0.05 13.2 18.5 0.61 9.7 2.9 3.2 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA23064.1 - 0.18 11.5 10.0 0.36 10.5 0.2 3.3 3 0 0 3 3 3 0 RING-type zinc-finger C1_1 PF00130.17 ESA23064.1 - 0.27 11.0 6.9 1.8 8.3 0.0 3.1 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Uma2 PF05685.7 ESA23065.1 - 3.5e-10 39.5 0.0 4.9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Putative restriction endonuclease zf-C3HC4_2 PF13923.1 ESA23066.1 - 0.00015 21.6 1.9 0.00015 21.6 1.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA23066.1 - 0.00025 20.6 2.5 0.00025 20.6 1.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA23066.1 - 0.00047 19.9 2.9 0.00047 19.9 2.0 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.20 ESA23066.1 - 0.00065 19.3 3.8 0.0016 18.0 2.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA23066.1 - 0.00087 19.3 0.8 0.0018 18.3 0.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 ESA23066.1 - 0.002 17.8 3.7 0.002 17.8 2.6 1.8 2 0 0 2 2 2 1 zinc-RING finger domain Mre11_DNA_bind PF04152.9 ESA23067.1 - 0.025 14.4 2.3 0.066 13.0 1.2 1.8 2 0 0 2 2 2 0 Mre11 DNA-binding presumed domain PGC7_Stella PF15549.1 ESA23067.1 - 0.026 14.5 0.2 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Ion_trans PF00520.26 ESA23070.1 - 5.5e-09 35.5 9.8 1.1e-08 34.6 6.8 1.5 1 0 0 1 1 1 1 Ion transport protein DUF2782 PF11191.3 ESA23070.1 - 0.057 13.3 1.1 4 7.4 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2782) Tropomyosin_1 PF12718.2 ESA23070.1 - 0.13 12.1 34.7 0.32 10.8 24.0 1.6 1 0 0 1 1 1 0 Tropomyosin like Phage_Gp19 PF09355.5 ESA23072.1 - 0.034 13.9 1.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 PAS_11 PF14598.1 ESA23074.1 - 0.0069 16.3 0.0 0.044 13.7 0.0 2.2 3 0 0 3 3 3 1 PAS domain LacI PF00356.16 ESA23074.1 - 1.1 8.9 6.3 0.13 11.9 0.6 2.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family RicinB_lectin_2 PF14200.1 ESA23075.1 - 2.2e-08 34.3 0.8 6e-08 33.0 0.6 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain-like Aerolysin PF01117.15 ESA23075.1 - 0.00015 20.8 1.4 0.0003 19.8 1.0 1.4 1 0 0 1 1 1 1 Aerolysin toxin ETX_MTX2 PF03318.8 ESA23075.1 - 0.00054 19.5 10.0 0.00054 19.5 7.0 2.6 1 1 0 2 2 2 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 DUF2951 PF11166.3 ESA23075.1 - 2.6 7.9 7.3 0.29 11.0 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2951) NOD PF06816.8 ESA23076.1 - 0.012 14.6 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 NOTCH protein MULE PF10551.4 ESA23077.1 - 0.0049 16.9 0.0 0.0077 16.3 0.0 1.3 1 0 0 1 1 1 1 MULE transposase domain DUF1838 PF08894.6 ESA23077.1 - 0.13 11.4 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1838) ZZ PF00569.12 ESA23078.1 - 4.3e-06 26.1 4.3 4.3e-06 26.1 3.0 1.8 2 1 0 2 2 2 1 Zinc finger, ZZ type zf-UBR PF02207.15 ESA23078.1 - 1.1 8.9 6.2 17 5.2 4.3 2.1 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Prok-RING_1 PF14446.1 ESA23078.1 - 2.4 7.9 9.3 0.2 11.3 2.3 2.3 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 O-FucT PF10250.4 ESA23079.1 - 4.7e-12 45.6 4.4 9.4e-09 34.8 0.5 2.7 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Carn_acyltransf PF00755.15 ESA23080.1 - 1.2e-165 552.0 0.0 1.4e-165 551.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Med13_C PF06333.7 ESA23081.1 - 3.7 5.9 8.3 5.5 5.4 5.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal CKS PF01111.14 ESA23082.1 - 0.09 12.6 0.3 0.21 11.4 0.2 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase regulatory subunit Kelch_5 PF13854.1 ESA23083.1 - 1.5e-08 34.3 9.3 0.33 10.9 0.3 5.7 6 0 0 6 6 5 4 Kelch motif Kelch_6 PF13964.1 ESA23083.1 - 6e-06 26.2 15.4 1.4 9.2 0.0 6.3 6 1 0 6 6 6 3 Kelch motif SKG6 PF08693.5 ESA23083.1 - 3.2e-05 23.1 1.3 6.1e-05 22.2 0.9 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_2 PF07646.10 ESA23083.1 - 9.3e-05 22.0 0.9 3.8 7.4 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 ESA23083.1 - 0.00012 21.7 18.1 0.045 13.5 0.1 5.9 6 2 0 6 6 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA23083.1 - 0.00018 20.9 12.5 2.3 7.8 0.0 5.1 5 0 0 5 5 5 2 Kelch motif ASFV_J13L PF05568.6 ESA23083.1 - 0.00076 19.0 0.1 0.0014 18.1 0.1 1.4 1 0 0 1 1 1 1 African swine fever virus J13L protein Rax2 PF12768.2 ESA23083.1 - 0.001 18.3 1.3 0.031 13.4 0.0 2.7 3 0 0 3 3 3 1 Cortical protein marker for cell polarity Kelch_3 PF13415.1 ESA23083.1 - 0.0028 17.7 13.7 4.3 7.6 0.3 5.9 6 1 0 6 6 6 2 Galactose oxidase, central domain EphA2_TM PF14575.1 ESA23083.1 - 0.0032 17.8 0.0 0.007 16.7 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain RCR PF12273.3 ESA23083.1 - 0.0034 17.9 0.1 0.0076 16.8 0.0 1.6 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Rifin_STEVOR PF02009.11 ESA23083.1 - 0.007 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Rifin/stevor family Mid2 PF04478.7 ESA23083.1 - 0.0072 15.7 0.4 0.014 14.8 0.3 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor TMEM154 PF15102.1 ESA23083.1 - 0.0078 15.9 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family Adeno_E3_CR2 PF02439.10 ESA23083.1 - 0.0078 15.7 2.4 0.017 14.6 1.7 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 ODV-E18 PF10717.4 ESA23083.1 - 0.0079 15.6 0.3 0.018 14.4 0.2 1.6 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Protocadherin PF08374.6 ESA23083.1 - 0.034 13.7 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Protocadherin DUF912 PF06024.7 ESA23083.1 - 0.04 13.9 0.7 0.073 13.1 0.0 1.8 2 0 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) MSC PF09402.5 ESA23083.1 - 0.066 11.9 0.0 0.097 11.3 0.0 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain IgaA PF07095.6 ESA23083.1 - 0.09 10.5 0.0 0.36 8.5 0.0 1.7 2 0 0 2 2 2 0 Intracellular growth attenuator protein IgaA BatA PF07584.6 ESA23083.1 - 0.96 9.6 3.0 0.34 11.1 0.1 1.6 2 0 0 2 2 1 0 Aerotolerance regulator N-terminal CoatB PF10389.4 ESA23083.1 - 2.7 7.9 5.4 6 6.8 3.7 1.5 1 0 0 1 1 1 0 Bacteriophage coat protein B YajC PF02699.10 ESA23083.1 - 3.9 7.2 6.1 0.91 9.2 0.4 2.6 3 0 0 3 3 3 0 Preprotein translocase subunit Kelch_3 PF13415.1 ESA23084.1 - 4.2e-07 29.9 6.8 0.045 13.9 1.1 3.4 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA23084.1 - 0.0015 18.4 2.4 0.34 10.9 0.6 2.9 2 1 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 ESA23084.1 - 0.0029 17.3 0.3 0.0029 17.3 0.2 3.9 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA23084.1 - 0.0056 16.8 7.6 0.45 10.7 0.5 2.9 2 2 1 3 3 3 2 Kelch motif Rax2 PF12768.2 ESA23084.1 - 0.016 14.4 0.5 0.16 11.1 0.4 1.9 1 1 0 1 1 1 0 Cortical protein marker for cell polarity DUF3169 PF11368.3 ESA23084.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) ASFV_J13L PF05568.6 ESA23084.1 - 0.038 13.5 0.1 0.057 12.9 0.1 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein SID-1_RNA_chan PF13965.1 ESA23084.1 - 0.038 12.1 0.0 0.047 11.8 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TMEM154 PF15102.1 ESA23084.1 - 0.12 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family RCR PF12273.3 ESA23084.1 - 0.15 12.6 0.1 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red CoatB PF10389.4 ESA23084.1 - 0.32 10.8 1.7 0.6 10.0 1.2 1.4 1 0 0 1 1 1 0 Bacteriophage coat protein B SKG6 PF08693.5 ESA23084.1 - 1.4 8.2 3.9 3.1 7.2 2.7 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain zf-AD PF07776.10 ESA23085.1 - 0.01 15.7 2.1 0.015 15.2 0.2 2.0 2 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) UQ_con PF00179.21 ESA23088.1 - 1.4e-16 60.1 0.3 4.2e-16 58.6 0.2 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Motile_Sperm PF00635.21 ESA23089.1 - 2.6e-17 62.4 0.1 3e-17 62.2 0.1 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Alpha-amylase_C PF02806.13 ESA23089.1 - 0.021 14.9 0.0 0.022 14.8 0.0 1.0 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain TLD PF07534.11 ESA23090.1 - 2.7e-09 37.1 0.7 3.7e-09 36.6 0.5 1.2 1 0 0 1 1 1 1 TLD ABC_tran PF00005.22 ESA23091.1 - 6.1e-51 172.3 0.3 1.5e-30 106.2 0.1 2.7 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 ESA23091.1 - 1.2e-45 156.0 56.8 9.2e-25 87.5 18.0 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 ESA23091.1 - 5.5e-09 35.5 8.6 0.00023 20.4 3.2 4.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain T2SE PF00437.15 ESA23091.1 - 3.1e-06 26.3 0.1 0.033 13.0 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_10 PF12846.2 ESA23091.1 - 1.4e-05 24.6 0.1 0.34 10.3 0.0 3.8 4 0 0 4 4 4 2 AAA-like domain AAA_22 PF13401.1 ESA23091.1 - 2.6e-05 24.3 3.3 0.085 12.9 0.1 3.4 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.1 ESA23091.1 - 7.2e-05 22.2 0.2 0.074 12.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 ESA23091.1 - 9.5e-05 23.2 0.1 0.4 11.4 0.0 3.4 3 0 0 3 3 2 1 AAA domain FtsK_SpoIIIE PF01580.13 ESA23091.1 - 0.0001 21.8 0.0 0.5 9.8 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_25 PF13481.1 ESA23091.1 - 0.0002 20.8 0.0 0.3 10.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.1 ESA23091.1 - 0.00041 20.7 19.7 0.00044 20.6 0.5 4.5 2 2 1 4 4 4 1 AAA domain AAA_16 PF13191.1 ESA23091.1 - 0.00054 20.0 0.0 0.52 10.2 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.24 ESA23091.1 - 0.0022 18.2 1.0 0.84 9.8 0.0 3.7 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 ESA23091.1 - 0.0024 17.1 0.0 0.32 10.1 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 DUF2075 PF09848.4 ESA23091.1 - 0.0031 16.5 0.0 0.18 10.7 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) MobB PF03205.9 ESA23091.1 - 0.0063 16.2 0.0 0.9 9.2 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.10 ESA23091.1 - 0.011 15.6 5.3 0.36 10.6 0.4 3.1 2 2 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.1 ESA23091.1 - 0.011 16.0 7.0 0.98 9.7 0.2 3.8 4 1 0 4 4 2 0 AAA domain IstB_IS21 PF01695.12 ESA23091.1 - 0.011 15.1 0.0 0.6 9.5 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.24 ESA23091.1 - 0.013 14.9 0.3 4.5 6.7 0.0 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase DUF87 PF01935.12 ESA23091.1 - 0.014 15.2 2.2 0.14 11.9 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function DUF87 MMR_HSR1 PF01926.18 ESA23091.1 - 0.019 14.9 0.0 1.4 8.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase CbiA PF01656.18 ESA23091.1 - 0.019 14.3 0.1 0.077 12.3 0.0 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.1 ESA23091.1 - 0.02 14.7 0.1 2 8.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 ESA23091.1 - 0.022 14.4 0.1 30 4.3 0.0 4.0 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Miro PF08477.8 ESA23091.1 - 0.043 14.3 0.5 22 5.5 0.0 3.2 2 1 0 2 2 2 0 Miro-like protein SbcCD_C PF13558.1 ESA23091.1 - 0.052 13.4 0.1 15 5.6 0.0 2.7 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.7 ESA23091.1 - 0.092 12.3 0.0 1.7 8.2 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.1 ESA23091.1 - 0.6 9.6 0.2 44 3.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain Cytokin_check_N PF10407.4 ESA23093.1 - 0.035 13.7 1.0 0.064 12.8 0.7 1.6 1 1 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus E1_DerP2_DerF2 PF02221.10 ESA23094.1 - 8.9e-06 25.9 0.1 1.1e-05 25.6 0.1 1.1 1 0 0 1 1 1 1 ML domain GAS PF13851.1 ESA23097.1 - 9.6e-05 21.6 2.0 0.00018 20.8 0.6 1.7 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF2884 PF11101.3 ESA23097.1 - 0.0044 16.4 2.3 0.0059 16.0 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2884) TMF_DNA_bd PF12329.3 ESA23097.1 - 0.0045 16.7 4.6 0.028 14.2 0.2 2.4 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF489 PF04356.7 ESA23097.1 - 0.011 15.2 0.4 0.015 14.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Filament PF00038.16 ESA23097.1 - 0.012 15.0 0.6 0.017 14.5 0.4 1.2 1 0 0 1 1 1 0 Intermediate filament protein bZIP_1 PF00170.16 ESA23097.1 - 0.016 15.1 2.7 1 9.3 0.3 2.4 2 0 0 2 2 2 0 bZIP transcription factor Laminin_I PF06008.9 ESA23097.1 - 0.017 14.4 0.3 0.023 14.0 0.2 1.2 1 0 0 1 1 1 0 Laminin Domain I FlaC_arch PF05377.6 ESA23097.1 - 0.022 14.6 4.2 0.052 13.4 0.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.6 ESA23097.1 - 0.025 14.4 0.1 1.6 8.6 0.0 2.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF972 PF06156.8 ESA23097.1 - 0.027 14.8 4.1 0.1 12.9 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF972) FAD_binding_1 PF00667.15 ESA23097.1 - 0.031 13.7 0.0 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Snapin_Pallidin PF14712.1 ESA23097.1 - 0.039 14.2 5.6 0.6 10.4 2.5 2.9 3 1 0 3 3 2 0 Snapin/Pallidin DUF4200 PF13863.1 ESA23097.1 - 0.041 13.8 2.2 0.42 10.5 1.5 2.2 2 1 0 2 2 1 0 Domain of unknown function (DUF4200) DUF4140 PF13600.1 ESA23097.1 - 0.044 14.2 0.4 1.2 9.6 0.0 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Reo_sigmaC PF04582.7 ESA23097.1 - 0.057 12.6 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Baculo_PEP_C PF04513.7 ESA23097.1 - 0.057 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.9 ESA23097.1 - 0.059 12.7 0.2 0.095 12.1 0.2 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF2408 PF10303.4 ESA23097.1 - 0.064 13.3 2.8 0.076 13.1 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) CENP-F_leu_zip PF10473.4 ESA23097.1 - 0.068 13.0 2.6 0.77 9.6 0.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBPIP PF07106.8 ESA23097.1 - 0.07 12.6 2.6 0.13 11.8 1.7 1.6 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) SlyX PF04102.7 ESA23097.1 - 0.083 13.2 0.1 0.47 10.8 0.0 2.1 2 0 0 2 2 2 0 SlyX AAA_13 PF13166.1 ESA23097.1 - 0.085 11.2 0.6 0.12 10.8 0.4 1.1 1 0 0 1 1 1 0 AAA domain HSBP1 PF06825.7 ESA23097.1 - 0.091 12.3 2.0 0.22 11.0 0.3 2.4 2 1 0 2 2 2 0 Heat shock factor binding protein 1 CorA PF01544.13 ESA23097.1 - 0.092 11.7 0.5 0.42 9.6 0.4 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF4559 PF15112.1 ESA23097.1 - 0.092 11.8 4.0 0.037 13.1 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) AAA_27 PF13514.1 ESA23097.1 - 0.11 10.1 0.1 0.13 9.8 0.0 1.0 1 0 0 1 1 1 0 AAA domain Cep57_CLD_2 PF14197.1 ESA23097.1 - 0.12 12.3 3.9 0.89 9.5 2.7 2.2 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Prefoldin_3 PF13758.1 ESA23097.1 - 0.12 12.1 0.6 0.27 11.0 0.4 1.6 1 1 0 1 1 1 0 Prefoldin subunit Laminin_II PF06009.7 ESA23097.1 - 0.12 12.1 0.2 0.21 11.3 0.2 1.4 1 0 0 1 1 1 0 Laminin Domain II Syntaxin_2 PF14523.1 ESA23097.1 - 0.12 12.3 1.4 3.3 7.8 0.9 2.2 1 1 0 1 1 1 0 Syntaxin-like protein MAP65_ASE1 PF03999.7 ESA23097.1 - 0.13 10.8 1.2 0.16 10.4 0.9 1.3 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DivIC PF04977.10 ESA23097.1 - 0.14 11.6 4.5 0.64 9.5 0.4 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF342 PF03961.8 ESA23097.1 - 0.15 10.4 0.5 0.17 10.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FlxA PF14282.1 ESA23097.1 - 0.16 11.9 0.8 13 5.7 0.1 2.2 2 0 0 2 2 2 0 FlxA-like protein WEMBL PF05701.6 ESA23097.1 - 0.2 10.0 1.3 0.25 9.7 0.9 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Cep57_MT_bd PF06657.8 ESA23097.1 - 0.21 11.5 1.7 0.75 9.7 0.1 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 SF-assemblin PF06705.6 ESA23097.1 - 0.22 10.6 2.4 0.79 8.8 1.7 1.7 1 1 0 1 1 1 0 SF-assemblin/beta giardin MitMem_reg PF13012.1 ESA23097.1 - 0.27 11.3 2.1 9.8 6.3 0.2 2.5 1 1 1 3 3 3 0 Maintenance of mitochondrial structure and function DUF2205 PF10224.4 ESA23097.1 - 0.28 10.7 2.6 0.68 9.5 0.3 2.2 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Gp-FAR-1 PF05823.7 ESA23097.1 - 0.29 11.0 2.1 1 9.3 0.1 2.2 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) BLOC1_2 PF10046.4 ESA23097.1 - 0.39 10.8 3.3 1.6 8.9 2.3 1.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Myosin_tail_1 PF01576.14 ESA23097.1 - 0.43 8.2 3.5 0.89 7.1 2.1 1.4 1 1 0 1 1 1 0 Myosin tail APG6 PF04111.7 ESA23097.1 - 0.43 9.5 3.1 0.9 8.5 1.5 1.7 1 1 1 2 2 2 0 Autophagy protein Apg6 Cauli_AT PF03233.8 ESA23097.1 - 0.53 9.9 2.6 0.9 9.2 0.2 2.1 1 1 1 2 2 2 0 Aphid transmission protein TMF_TATA_bd PF12325.3 ESA23097.1 - 0.67 9.7 5.5 0.28 10.9 2.1 1.6 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding Prefoldin_2 PF01920.15 ESA23097.1 - 1 9.1 7.8 16 5.3 4.2 2.9 2 1 0 2 2 2 0 Prefoldin subunit Spc24 PF08286.6 ESA23097.1 - 2.1 8.0 5.4 1.2 8.8 0.4 2.4 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Seryl_tRNA_N PF02403.17 ESA23097.1 - 2.3 8.3 7.6 1.5 8.8 0.2 2.5 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain DUF3837 PF12939.2 ESA23098.1 - 0.13 12.2 0.1 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) NYD-SP28_assoc PF14775.1 ESA23098.1 - 0.17 11.6 0.4 0.32 10.7 0.3 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain HALZ PF02183.13 ESA23098.1 - 0.3 10.8 2.6 0.7 9.6 1.8 1.7 1 1 0 1 1 1 0 Homeobox associated leucine zipper Asp-B-Hydro_N PF05279.6 ESA23099.1 - 0.76 9.5 13.5 0.97 9.2 9.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region NYD-SP28_assoc PF14775.1 ESA23099.1 - 1.1 9.0 5.4 2.8 7.6 0.3 2.8 2 1 1 3 3 3 0 Sperm tail C-terminal domain DUF2681 PF10883.3 ESA23099.1 - 6.3 7.0 13.5 0.21 11.8 1.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2681) AAA_22 PF13401.1 ESA23102.1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 ESA23102.1 - 0.016 15.1 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 ESA23102.1 - 0.027 13.3 0.0 0.035 13.0 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.1 ESA23102.1 - 0.091 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 ESA23102.1 - 0.11 12.8 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain bZIP_1 PF00170.16 ESA23103.1 - 0.001 18.9 15.5 0.052 13.5 0.8 3.1 1 1 2 3 3 3 2 bZIP transcription factor HTH_39 PF14090.1 ESA23103.1 - 0.0038 16.6 2.3 2.5 7.6 0.1 3.4 1 1 2 3 3 3 1 Helix-turn-helix domain DivIC PF04977.10 ESA23103.1 - 0.02 14.3 16.1 0.41 10.1 0.6 3.0 1 1 2 3 3 3 0 Septum formation initiator DUF4201 PF13870.1 ESA23103.1 - 0.022 14.1 10.2 0.13 11.6 6.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF904 PF06005.7 ESA23103.1 - 0.038 14.2 15.6 17 5.7 10.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF904) TMF_TATA_bd PF12325.3 ESA23103.1 - 0.041 13.6 8.4 0.069 12.8 5.8 1.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF972 PF06156.8 ESA23103.1 - 0.053 13.8 9.5 3.9 7.8 6.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF972) CENP-H PF05837.7 ESA23103.1 - 0.053 13.6 8.3 0.037 14.2 4.5 1.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) SAB PF04382.8 ESA23103.1 - 0.1 12.2 7.0 0.43 10.3 0.4 2.8 1 1 2 3 3 3 0 SAB domain PEARLI-4 PF05278.7 ESA23103.1 - 0.11 11.9 6.9 0.078 12.3 4.0 1.4 1 1 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) IncA PF04156.9 ESA23103.1 - 0.18 11.3 6.5 0.24 10.9 4.5 1.2 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.6 ESA23103.1 - 0.18 10.3 9.2 0.23 10.1 6.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.2 ESA23103.1 - 0.19 11.5 11.9 0.24 11.2 8.3 1.1 1 0 0 1 1 1 0 Tropomyosin like Spectrin PF00435.16 ESA23103.1 - 0.22 11.8 6.0 0.27 11.5 4.1 1.1 1 0 0 1 1 1 0 Spectrin repeat ADIP PF11559.3 ESA23103.1 - 0.23 11.3 9.9 0.36 10.7 6.9 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FlxA PF14282.1 ESA23103.1 - 0.25 11.3 2.6 0.32 10.9 1.8 1.2 1 0 0 1 1 1 0 FlxA-like protein DUF812 PF05667.6 ESA23103.1 - 0.28 9.6 8.4 0.29 9.5 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) bZIP_2 PF07716.10 ESA23103.1 - 0.29 10.9 14.3 0.87 9.4 0.4 3.2 2 1 1 3 3 3 0 Basic region leucine zipper Mnd1 PF03962.10 ESA23103.1 - 0.35 10.4 6.5 0.36 10.4 4.1 1.3 1 1 0 1 1 1 0 Mnd1 family Toxin_39 PF15500.1 ESA23103.1 - 0.5 10.5 5.2 1 9.5 3.6 1.6 1 1 0 1 1 1 0 Putative RNase-like toxin Striatin PF08232.7 ESA23103.1 - 0.57 10.4 10.8 0.14 12.4 4.5 1.9 1 1 1 2 2 2 0 Striatin family Atg14 PF10186.4 ESA23103.1 - 0.71 8.7 12.0 0.88 8.4 8.4 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_GP20 PF06810.6 ESA23103.1 - 0.78 9.1 12.2 0.37 10.2 2.7 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF4200 PF13863.1 ESA23103.1 - 0.81 9.6 14.9 5.9 6.8 10.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Uso1_p115_C PF04871.8 ESA23103.1 - 0.93 9.4 9.4 3.4 7.6 6.5 1.8 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF641 PF04859.7 ESA23103.1 - 1 9.1 8.2 0.3 10.8 1.1 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) BLOC1_2 PF10046.4 ESA23103.1 - 1.1 9.4 6.7 0.26 11.4 1.0 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-Q PF13094.1 ESA23103.1 - 1.7 8.6 8.9 3.4 7.6 6.1 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4337 PF14235.1 ESA23103.1 - 1.8 8.4 6.7 2.5 7.8 4.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) Ax_dynein_light PF10211.4 ESA23103.1 - 2.2 8.0 12.3 4.1 7.1 8.5 1.5 1 1 0 1 1 1 0 Axonemal dynein light chain Viral_P18 PF04521.8 ESA23103.1 - 2.2 7.7 5.6 12 5.4 3.8 2.0 1 1 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein TPR_MLP1_2 PF07926.7 ESA23103.1 - 2.6 7.7 14.9 3.4 7.4 4.5 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.3 ESA23103.1 - 3 7.7 15.8 5.1 6.9 5.9 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.1 ESA23103.1 - 3.1 6.1 11.4 3.6 5.9 7.9 1.1 1 0 0 1 1 1 0 AAA domain TSC22 PF01166.13 ESA23103.1 - 3.5 7.6 11.5 5.3 7.0 1.0 3.3 1 1 2 3 3 3 0 TSC-22/dip/bun family DUF4140 PF13600.1 ESA23103.1 - 3.7 8.0 7.6 2.1 8.8 1.6 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TMPIT PF07851.8 ESA23103.1 - 4.7 6.1 5.5 5.1 6.0 3.8 1.0 1 0 0 1 1 1 0 TMPIT-like protein HALZ PF02183.13 ESA23103.1 - 5 6.9 11.0 4.2 7.1 0.6 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper FlgN PF05130.7 ESA23103.1 - 5.2 7.3 8.9 6.3 7.0 6.2 1.1 1 0 0 1 1 1 0 FlgN protein DUF724 PF05266.9 ESA23103.1 - 5.6 6.5 9.7 6.7 6.2 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) APG6 PF04111.7 ESA23103.1 - 6.6 5.6 8.7 7.8 5.4 6.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 FlaC_arch PF05377.6 ESA23103.1 - 6.8 6.6 7.7 48 3.9 1.5 3.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Spc24 PF08286.6 ESA23103.1 - 7.1 6.3 9.2 7.1 6.3 1.4 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SopA PF13981.1 ESA23105.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 SopA-like central domain Wx5_PLAF3D7 PF09688.5 ESA23107.1 - 0.024 14.5 2.1 0.028 14.3 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) DUF1788 PF08747.6 ESA23113.1 - 0.088 12.6 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) DUF3325 PF11804.3 ESA23115.1 - 0.21 11.5 8.5 0.43 10.5 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3325) MFS_1 PF07690.11 ESA23117.1 - 0.0024 16.6 10.4 0.0041 15.8 7.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily AgrB PF04647.10 ESA23117.1 - 0.024 13.7 6.5 0.037 13.0 4.5 1.3 1 0 0 1 1 1 0 Accessory gene regulator B ATPase_gene1 PF09527.5 ESA23117.1 - 0.23 11.2 4.4 0.23 11.2 1.9 2.0 1 1 0 1 1 1 0 Putative F0F1-ATPase subunit (ATPase_gene1) Rhomboid PF01694.17 ESA23117.1 - 4.5 7.2 8.5 9.1 6.2 5.9 1.6 1 1 0 1 1 1 0 Rhomboid family PMT_2 PF13231.1 ESA23117.1 - 8.6 6.2 10.4 0.54 10.1 0.3 2.1 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Med21 PF11221.3 ESA23118.1 - 1.4e-23 83.4 13.8 3.8e-16 59.3 6.5 2.1 1 1 1 2 2 2 2 Subunit 21 of Mediator complex Fmp27_WPPW PF10359.4 ESA23118.1 - 0.0039 15.6 5.0 0.0068 14.8 3.5 1.4 1 1 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Syntaxin_2 PF14523.1 ESA23118.1 - 0.0063 16.5 7.2 0.012 15.5 5.0 1.5 1 1 0 1 1 1 1 Syntaxin-like protein DUF781 PF05612.7 ESA23118.1 - 0.022 13.4 1.6 0.027 13.1 1.1 1.0 1 0 0 1 1 1 0 Mouse protein of unknown function (DUF781) Barstar PF01337.13 ESA23118.1 - 0.026 14.3 0.4 0.2 11.5 0.1 2.2 2 1 0 2 2 2 0 Barstar (barnase inhibitor) IncA PF04156.9 ESA23118.1 - 0.043 13.4 8.6 0.053 13.1 6.0 1.1 1 0 0 1 1 1 0 IncA protein Med9 PF07544.8 ESA23118.1 - 0.049 13.3 0.5 0.049 13.3 0.4 2.5 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Ham1p_like PF01725.11 ESA23118.1 - 0.059 12.7 2.5 0.12 11.7 1.7 1.7 1 1 0 1 1 1 0 Ham1 family APG6 PF04111.7 ESA23118.1 - 0.13 11.3 8.3 0.15 11.0 5.8 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 TMF_DNA_bd PF12329.3 ESA23118.1 - 0.82 9.5 7.8 0.6 9.9 3.9 1.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF2508 PF10704.4 ESA23118.1 - 1.2 9.3 5.6 8.7 6.5 1.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) DUF948 PF06103.6 ESA23118.1 - 8 6.3 7.4 3.6 7.4 1.8 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF730 PF05325.6 ESA23118.1 - 9.4 6.0 7.0 7.5 6.3 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF730) Gti1_Pac2 PF09729.4 ESA23119.1 - 6.3e-34 117.2 0.2 6.7e-34 117.1 0.1 1.0 1 0 0 1 1 1 1 Gti1/Pac2 family Kelch_5 PF13854.1 ESA23120.1 - 2.2e-16 59.3 1.9 0.00089 19.1 0.1 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.1 ESA23120.1 - 2.4e-15 56.0 16.6 0.0044 16.7 0.0 7.5 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA23120.1 - 4e-14 51.7 3.4 0.0063 16.2 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 ESA23120.1 - 8.6e-13 47.8 9.7 0.1 12.8 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.1 ESA23120.1 - 1.4e-11 44.2 1.9 0.042 14.0 0.0 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.20 ESA23120.1 - 8.2e-11 41.2 9.8 0.001 18.5 0.1 5.8 6 0 0 6 6 5 4 Kelch motif Mid2 PF04478.7 ESA23120.1 - 0.00059 19.2 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF3609 PF12259.3 ESA23120.1 - 0.00099 17.8 0.0 0.0015 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3609) TMEM154 PF15102.1 ESA23120.1 - 0.0068 16.1 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.5 ESA23120.1 - 0.026 13.8 0.5 0.026 13.8 0.3 1.9 2 0 0 2 2 1 0 Transmembrane alpha-helix domain DUF1746 PF08508.5 ESA23120.1 - 0.031 14.2 0.2 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 Fungal domain of unknown function (DUF1746) Flu_M2 PF00599.12 ESA23120.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Influenza Matrix protein (M2) Adeno_E3_CR2 PF02439.10 ESA23120.1 - 0.17 11.4 3.1 0.61 9.6 2.1 1.9 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4064 PF13273.1 ESA23120.1 - 2.1 8.5 6.3 0.24 11.5 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DUF1796 PF08795.5 ESA23121.1 - 0.071 12.7 1.0 0.086 12.4 0.7 1.5 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Pkinase_Tyr PF07714.12 ESA23122.1 - 9e-31 106.8 0.0 1.4e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23122.1 - 1.1e-28 100.0 0.2 1.9e-28 99.3 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain THP2 PF09432.5 ESA23122.1 - 0.0081 16.0 0.1 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Tho complex subunit THP2 APH_6_hur PF04655.9 ESA23122.1 - 0.04 13.0 0.1 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase RIO1 PF01163.17 ESA23122.1 - 0.048 13.0 0.1 0.1 11.9 0.1 1.5 1 0 0 1 1 1 0 RIO1 family ADK_lid PF05191.9 ESA23122.1 - 0.67 9.6 0.0 0.67 9.6 0.0 3.3 5 0 0 5 5 5 0 Adenylate kinase, active site lid adh_short PF00106.20 ESA23123.1 - 3.3e-34 118.2 0.1 4.2e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA23123.1 - 2e-19 70.3 0.0 2.6e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA23123.1 - 4.1e-13 49.3 0.0 5.6e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 ESA23123.1 - 5.7e-06 25.9 0.5 1.4e-05 24.6 0.1 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 ESA23123.1 - 6.6e-05 21.9 0.4 0.00011 21.2 0.3 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 ESA23123.1 - 0.00011 22.3 0.2 0.00036 20.5 0.1 1.9 1 1 0 1 1 1 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 ESA23123.1 - 0.002 17.8 0.3 0.0043 16.7 0.2 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.15 ESA23123.1 - 0.009 16.1 0.2 0.021 14.9 0.2 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF1776 PF08643.5 ESA23123.1 - 0.036 13.1 0.0 0.057 12.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.12 ESA23123.1 - 0.11 11.3 0.2 0.45 9.3 0.1 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Med15_fungi PF05397.7 ESA23123.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 15 Pox_MCEL PF03291.11 ESA23124.1 - 4.3e-89 298.6 0.8 4.8e-89 298.4 0.5 1.0 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_31 PF13847.1 ESA23124.1 - 1.7e-10 40.7 0.0 2.3e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA23124.1 - 3.4e-08 33.8 0.0 5.7e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA23124.1 - 2.2e-07 30.7 0.0 3.5e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 ESA23124.1 - 3.7e-07 30.5 0.0 5.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23124.1 - 6.1e-07 30.0 0.0 9.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA23124.1 - 1.2e-06 28.7 0.0 2.9e-06 27.5 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 ESA23124.1 - 0.00013 21.0 0.0 0.00018 20.5 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.12 ESA23124.1 - 0.033 13.2 0.0 0.06 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase TPMT PF05724.6 ESA23124.1 - 0.081 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) KTI12 PF08433.5 ESA23125.1 - 4.1e-95 318.0 0.0 4.7e-95 317.8 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 ESA23125.1 - 1.2e-10 41.4 0.0 5e-10 39.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain Med19 PF10278.4 ESA23128.1 - 0.75 9.4 8.3 1.4 8.5 5.1 1.7 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.5 ESA23128.1 - 2.6 7.8 5.3 4.7 6.9 3.2 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NmrA PF05368.8 ESA23129.1 - 2.1e-25 89.3 0.3 3e-25 88.8 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 ESA23129.1 - 3.5e-06 27.1 0.0 8.5e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 ESA23129.1 - 0.018 14.0 0.1 0.029 13.3 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase KR PF08659.5 ESA23129.1 - 0.032 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.20 ESA23129.1 - 0.17 11.7 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase BTB PF00651.26 ESA23130.1 - 2.9e-16 59.4 0.0 1.3e-15 57.3 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23130.1 - 1.6e-10 41.1 2.2 1.6e-10 41.1 1.5 3.1 3 1 0 3 3 3 1 TLD BACK PF07707.10 ESA23130.1 - 0.1 12.4 2.3 0.16 11.8 0.6 2.2 2 1 0 2 2 2 0 BTB And C-terminal Kelch BACK PF07707.10 ESA23132.1 - 4.5e-07 29.6 1.2 9.7e-07 28.5 0.9 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF1759 PF03564.10 ESA23132.1 - 0.072 12.8 0.0 0.1 12.3 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) zf-RanBP PF00641.13 ESA23133.1 - 6.9e-06 25.0 34.8 0.011 14.7 2.1 5.2 5 0 0 5 5 5 4 Zn-finger in Ran binding protein and others DZR PF12773.2 ESA23133.1 - 2.6e-05 23.9 40.9 0.00035 20.3 8.9 4.0 4 0 0 4 4 4 3 Double zinc ribbon Nucleoplasmin PF03066.10 ESA23133.1 - 0.055 12.9 1.6 0.14 11.6 1.1 1.7 1 0 0 1 1 1 0 Nucleoplasmin zf-DHHC PF01529.15 ESA23133.1 - 6.5 6.1 23.2 1.3 8.4 0.2 3.8 2 1 1 3 3 3 0 DHHC palmitoyltransferase FGase PF05013.7 ESA23134.1 - 1.1e-09 38.4 0.0 2.9e-05 24.0 0.0 3.0 2 1 1 3 3 3 2 N-formylglutamate amidohydrolase Syntaxin PF00804.20 ESA23136.1 - 4.9e-15 55.5 5.1 4.9e-15 55.5 3.5 2.9 2 1 1 3 3 3 2 Syntaxin FAD_oxidored PF12831.2 ESA23136.1 - 0.0038 16.3 0.2 0.0054 15.8 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF4094 PF13334.1 ESA23136.1 - 0.026 14.9 1.0 0.026 14.9 0.7 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4094) SNARE PF05739.14 ESA23136.1 - 0.12 12.0 0.4 0.12 12.0 0.3 3.4 3 1 0 3 3 3 0 SNARE domain IncA PF04156.9 ESA23136.1 - 0.52 9.8 13.3 0.16 11.5 4.1 2.2 1 1 0 2 2 2 0 IncA protein DUF1732 PF08340.6 ESA23136.1 - 0.64 9.8 7.4 0.28 11.0 2.1 2.7 2 2 2 4 4 4 0 Domain of unknown function (DUF1732) Glu-tRNAGln PF02686.10 ESA23136.1 - 0.88 9.4 5.1 7.2 6.4 0.0 3.8 2 2 2 4 4 4 0 Glu-tRNAGln amidotransferase C subunit DUF3039 PF11238.3 ESA23137.1 - 0.07 12.5 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) Urm1 PF09138.6 ESA23139.1 - 0.12 12.5 2.4 0.57 10.3 1.0 2.4 1 1 1 2 2 2 0 Urm1 (Ubiquitin related modifier) DUF4507 PF14964.1 ESA23140.1 - 0.14 10.8 0.1 0.14 10.8 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) DUF4628 PF15429.1 ESA23141.1 - 0.049 13.0 0.4 0.052 12.9 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) CNF1 PF05785.7 ESA23142.1 - 0.14 11.0 0.3 0.17 10.7 0.2 1.1 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor PS_Dcarbxylase PF02666.10 ESA23143.1 - 0.076 12.3 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylserine decarboxylase SAM_1 PF00536.25 ESA23144.1 - 0.00012 22.1 0.0 0.00019 21.5 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) RinB PF06116.7 ESA23144.1 - 0.031 13.8 0.8 0.048 13.2 0.5 1.4 1 1 0 1 1 1 0 Transcriptional activator RinB p450 PF00067.17 ESA23147.1 - 8.1e-47 159.7 0.9 2.7e-46 158.0 0.6 1.7 1 1 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.23 ESA23148.1 - 5.8e-94 314.8 0.0 7.4e-94 314.4 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 ESA23148.1 - 3.4e-13 50.3 0.0 7.9e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Trp_syntA PF00290.15 ESA23148.1 - 0.0073 14.8 0.5 0.17 10.4 0.0 2.5 2 1 0 2 2 2 1 Tryptophan synthase alpha chain ADK PF00406.17 ESA23149.1 - 2.9e-09 36.9 1.5 5.7e-08 32.7 0.0 3.2 2 1 0 2 2 2 1 Adenylate kinase AAA_18 PF13238.1 ESA23149.1 - 0.0038 17.5 0.1 0.028 14.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 ESA23149.1 - 0.18 11.6 1.4 1.3 8.9 0.9 2.3 1 1 0 1 1 1 0 AAA domain MCM PF00493.18 ESA23150.1 - 4.9e-56 189.9 0.1 3.1e-37 128.1 0.4 3.5 2 1 2 4 4 4 3 MCM2/3/5 family Cas_Csy4 PF09618.5 ESA23150.1 - 0.042 13.6 0.3 0.2 11.4 0.1 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Na_Ca_ex PF01699.19 ESA23151.1 - 2.2e-48 163.4 34.4 2.6e-27 95.1 7.7 3.6 3 1 1 4 4 4 2 Sodium/calcium exchanger protein FA_desaturase PF00487.19 ESA23151.1 - 3.3 7.0 12.5 1.1 8.6 0.6 3.6 3 0 0 3 3 3 0 Fatty acid desaturase ESSS PF10183.4 ESA23151.1 - 3.9 7.9 4.7 73 3.8 0.0 3.6 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Phage_holin_6 PF10746.4 ESA23152.1 - 0.12 12.1 0.6 0.2 11.4 0.1 1.5 2 0 0 2 2 2 0 Phage holin family 6 Rifin_STEVOR PF02009.11 ESA23153.1 - 6.9e-05 22.6 0.0 6.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Rifin/stevor family Asp_protease_2 PF13650.1 ESA23153.1 - 0.011 16.2 0.0 0.11 12.9 0.0 2.1 1 1 1 2 2 2 0 Aspartyl protease RVP PF00077.15 ESA23153.1 - 0.087 12.7 0.0 18 5.3 0.0 2.8 1 1 2 3 3 3 0 Retroviral aspartyl protease DUF3635 PF12330.3 ESA23155.1 - 0.036 14.1 0.2 0.041 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3635) DUF273 PF03314.9 ESA23155.1 - 0.13 11.5 0.6 6.1 6.0 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF273 DUF4098 PF13345.1 ESA23156.1 - 8.9e-05 22.3 32.4 0.00091 19.1 5.2 4.4 2 1 1 3 3 3 2 Domain of unknown function (DUF4098) DAP10 PF07213.6 ESA23156.1 - 0.38 10.5 3.4 1.4 8.6 2.2 2.0 2 0 0 2 2 2 0 DAP10 membrane protein BTB PF00651.26 ESA23159.1 - 1.8e-09 37.5 0.0 2.1e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 ESA23160.1 - 2.5e-19 69.3 0.5 4.7e-19 68.4 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA23160.1 - 3.7e-08 33.1 6.2 8.3e-07 28.7 0.3 3.6 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA23160.1 - 0.034 13.2 0.2 0.065 12.3 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Skp1 PF01466.14 ESA23160.1 - 0.037 14.0 1.0 0.087 12.8 0.0 2.1 3 0 0 3 3 3 0 Skp1 family, dimerisation domain DUF1366 PF07104.6 ESA23160.1 - 0.075 12.6 2.4 0.14 11.7 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) TLD PF07534.11 ESA23161.1 - 3.3e-13 49.8 1.6 3.3e-13 49.8 1.1 2.2 2 0 0 2 2 2 1 TLD BTB PF00651.26 ESA23161.1 - 2e-11 43.8 0.1 3.7e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA23161.1 - 3.7e-05 23.5 1.6 0.00019 21.2 0.6 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 ESA23161.1 - 0.061 12.4 0.9 0.09 11.8 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) RasGEF_N PF00618.15 ESA23161.1 - 0.24 11.5 0.1 0.24 11.5 0.1 2.7 2 1 0 2 2 2 0 RasGEF N-terminal motif TRP PF06011.7 ESA23162.1 - 1.6e-08 33.6 6.9 1.9e-08 33.3 4.8 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF606 PF04657.8 ESA23162.1 - 0.063 13.3 3.5 0.075 13.1 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF606 Pkinase PF00069.20 ESA23164.1 - 0.025 13.7 0.0 0.035 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain DUF1870 PF08965.5 ESA23164.1 - 0.045 13.4 0.4 0.066 12.8 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1870) Thioredoxin PF00085.15 ESA23165.1 - 0.036 13.7 0.2 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin DUF1664 PF07889.7 ESA23165.1 - 0.2 11.4 3.9 0.29 10.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2362 PF10154.4 ESA23166.1 - 0.026 13.1 0.7 0.038 12.6 0.5 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) Fungal_trans_2 PF11951.3 ESA23166.1 - 0.031 12.8 0.2 0.15 10.6 0.1 1.8 2 0 0 2 2 2 0 Fungal specific transcription factor domain Phage_X PF05155.10 ESA23167.1 - 0.11 12.4 0.5 5.5 7.0 0.1 2.3 2 0 0 2 2 2 0 Phage X family HALZ PF02183.13 ESA23168.1 - 0.00069 19.2 5.8 0.022 14.4 0.6 2.1 1 1 1 2 2 2 2 Homeobox associated leucine zipper Rootletin PF15035.1 ESA23168.1 - 0.00081 19.4 1.4 0.0015 18.5 1.0 1.4 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Occludin_ELL PF07303.8 ESA23168.1 - 0.0026 18.4 1.1 0.0066 17.1 0.1 1.9 2 1 0 2 2 2 1 Occludin homology domain DUF1319 PF07028.6 ESA23168.1 - 0.0056 16.8 1.5 0.0056 16.8 1.0 1.5 2 0 0 2 2 1 1 Protein of unknown function (DUF1319) IncA PF04156.9 ESA23168.1 - 0.0074 15.9 3.8 0.012 15.1 2.7 1.3 1 0 0 1 1 1 1 IncA protein GAS PF13851.1 ESA23168.1 - 0.0096 15.1 1.2 0.015 14.4 0.8 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Prefoldin_2 PF01920.15 ESA23168.1 - 0.01 15.5 1.3 0.017 14.8 0.7 1.5 1 1 0 1 1 1 0 Prefoldin subunit Rop-like PF05082.8 ESA23168.1 - 0.011 15.2 1.7 0.18 11.2 0.1 2.4 2 0 0 2 2 2 0 Rop-like AAA_27 PF13514.1 ESA23168.1 - 0.012 13.3 0.5 0.014 13.1 0.3 1.1 1 0 0 1 1 1 0 AAA domain THOC7 PF05615.8 ESA23168.1 - 0.015 15.5 1.5 0.026 14.7 1.1 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 Vac_Fusion PF02346.11 ESA23168.1 - 0.015 14.6 0.7 0.033 13.6 0.4 1.6 1 1 0 1 1 1 0 Chordopoxvirus fusion protein ApoO PF09769.4 ESA23168.1 - 0.016 14.9 0.1 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein O EzrA PF06160.7 ESA23168.1 - 0.016 13.3 0.4 0.02 13.1 0.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Myosin_tail_1 PF01576.14 ESA23168.1 - 0.016 12.9 2.0 0.022 12.5 1.4 1.2 1 0 0 1 1 1 0 Myosin tail DUF342 PF03961.8 ESA23168.1 - 0.022 13.1 0.4 0.027 12.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ATG16 PF08614.6 ESA23168.1 - 0.032 14.0 3.3 0.048 13.4 0.7 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.17 ESA23168.1 - 0.034 14.1 0.8 0.073 13.1 0.5 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Lzipper-MIP1 PF14389.1 ESA23168.1 - 0.042 13.9 0.4 0.086 12.9 0.3 1.5 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Med11 PF10280.4 ESA23168.1 - 0.048 13.7 0.7 0.097 12.7 0.4 1.4 1 1 0 1 1 1 0 Mediator complex protein BLOC1_2 PF10046.4 ESA23168.1 - 0.051 13.7 0.7 0.075 13.1 0.5 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.10 ESA23168.1 - 0.053 13.0 0.9 0.13 11.7 0.6 1.8 1 1 0 1 1 1 0 Septum formation initiator Streptin-Immun PF11083.3 ESA23168.1 - 0.056 13.4 1.6 0.068 13.1 0.2 1.7 2 0 0 2 2 2 0 Lantibiotic streptin immunity protein FH2 PF02181.18 ESA23168.1 - 0.058 12.2 0.4 0.073 11.9 0.3 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain DUF3450 PF11932.3 ESA23168.1 - 0.058 12.6 1.1 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.6 ESA23168.1 - 0.058 13.8 1.6 0.33 11.3 1.1 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TPR_11 PF13414.1 ESA23168.1 - 0.071 12.7 0.2 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 TPR repeat ADIP PF11559.3 ESA23168.1 - 0.085 12.7 3.8 0.066 13.1 1.3 1.7 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding APG6 PF04111.7 ESA23168.1 - 0.087 11.8 1.7 0.12 11.4 1.2 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF1241 PF06840.6 ESA23168.1 - 0.087 12.0 0.5 0.13 11.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Lectin_N PF03954.9 ESA23168.1 - 0.089 12.1 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Syntaxin_2 PF14523.1 ESA23168.1 - 0.094 12.7 1.8 0.2 11.6 1.2 1.6 1 0 0 1 1 1 0 Syntaxin-like protein Lipid_DES PF08557.5 ESA23168.1 - 0.19 10.9 1.1 0.36 10.1 0.7 1.5 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) HR1 PF02185.11 ESA23168.1 - 0.2 11.4 3.2 0.53 10.0 2.2 1.7 1 1 0 1 1 1 0 Hr1 repeat Cep57_MT_bd PF06657.8 ESA23168.1 - 0.23 11.4 2.6 0.4 10.6 0.3 2.6 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 V-SNARE PF05008.10 ESA23168.1 - 2.7 8.2 6.7 1.2 9.3 0.5 2.8 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus CASP_C PF08172.7 ESA23169.1 - 0.11 11.4 11.6 0.13 11.2 8.0 1.2 1 0 0 1 1 1 0 CASP C terminal Cwf_Cwc_15 PF04889.7 ESA23169.1 - 0.2 11.3 17.1 0.29 10.8 11.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SpoIIIAH PF12685.2 ESA23169.1 - 1.4 8.3 17.6 1.5 8.2 12.2 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein RAP1 PF07218.6 ESA23169.1 - 1.9 6.5 26.9 1.9 6.5 18.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Golgin_A5 PF09787.4 ESA23169.1 - 2.1 6.7 24.7 2.2 6.7 17.1 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 Herpes_DNAp_acc PF04929.7 ESA23169.1 - 2.1 7.2 17.5 2.3 7.0 12.1 1.0 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CDC45 PF02724.9 ESA23169.1 - 3.1 5.7 18.4 3.2 5.6 12.8 1.0 1 0 0 1 1 1 0 CDC45-like protein PRP1_N PF06424.7 ESA23169.1 - 3.5 7.9 11.3 4.1 7.7 7.9 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Period_C PF12114.3 ESA23169.1 - 5.2 6.6 28.2 6.7 6.2 19.6 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region GET2 PF08690.5 ESA23169.1 - 7.7 5.6 15.3 9.7 5.3 10.6 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Apt1 PF10351.4 ESA23169.1 - 8 5.1 25.7 8.9 5.0 17.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DNA_pol_viral_N PF00242.12 ESA23169.1 - 8.5 5.2 21.3 9.8 5.0 14.8 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Pkinase PF00069.20 ESA23171.1 - 1.3e-05 24.4 1.2 1.5e-05 24.2 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain ELMO_CED12 PF04727.8 ESA23172.1 - 2.3e-34 118.3 0.6 1.1e-33 116.2 0.1 2.1 2 0 0 2 2 2 1 ELMO/CED-12 family DUF3361 PF11841.3 ESA23172.1 - 1.3e-13 51.0 2.3 2.9e-13 49.8 0.3 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) HARE-HTH PF05066.8 ESA23172.1 - 0.081 13.2 0.1 0.52 10.6 0.0 2.4 3 0 0 3 3 3 0 HB1, ASXL, restriction endonuclease HTH domain Nsp1_C PF05064.8 ESA23173.1 - 0.094 12.3 2.2 0.12 11.9 1.5 1.4 1 1 0 1 1 1 0 Nsp1-like C-terminal region COX16 PF14138.1 ESA23174.1 - 0.091 12.9 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 FAD-SLDH PF12318.3 ESA23176.1 - 0.11 12.2 1.4 0.2 11.3 0.9 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF1533 PF07550.6 ESA23177.1 - 1.1 9.3 6.3 0.13 12.2 0.4 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF1533) FliD_N PF02465.13 ESA23180.1 - 0.25 11.7 1.9 0.99 9.8 0.3 2.0 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus LINES_N PF14694.1 ESA23181.1 - 0.085 12.1 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Lines N-terminus DUF3883 PF13020.1 ESA23182.1 - 0.031 14.0 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) MmoB_DmpM PF02406.12 ESA23183.1 - 0.2 11.6 0.9 4.7 7.2 0.1 2.7 2 2 0 2 2 2 0 MmoB/DmpM family DUF443 PF04276.7 ESA23183.1 - 0.58 9.5 5.8 1.1 8.6 4.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF443) WD40 PF00400.27 ESA23184.1 - 0.00012 21.8 0.1 0.08 12.8 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat YfdX PF10938.3 ESA23185.1 - 0.14 11.8 0.1 0.32 10.6 0.0 1.6 1 1 0 1 1 1 0 YfdX protein DUF3764 PF12594.3 ESA23187.1 - 0.03 14.0 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) Cys_rich_VLP PF14194.1 ESA23188.1 - 0.016 14.9 2.3 0.016 14.9 1.6 2.1 2 0 0 2 2 2 0 Cysteine-rich VLP zf-CCHC PF00098.18 ESA23188.1 - 0.024 14.5 4.4 0.055 13.4 3.0 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.1 ESA23188.1 - 0.12 12.1 3.7 0.35 10.6 2.6 1.8 1 0 0 1 1 1 0 Zinc knuckle Methyltransf_11 PF08241.7 ESA23190.1 - 1.4e-05 25.4 0.0 2.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA23190.1 - 2.7e-05 23.4 0.1 0.00029 20.0 0.0 2.2 2 1 1 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA23190.1 - 6e-05 23.3 0.0 0.00032 20.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA23190.1 - 0.00018 21.1 0.0 0.00029 20.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA23190.1 - 0.0021 17.8 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA23190.1 - 0.0037 17.7 0.0 0.008 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.13 ESA23190.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MSA-2c PF12238.3 ESA23190.1 - 0.025 14.2 0.2 0.057 13.0 0.1 1.7 1 1 0 1 1 1 0 Merozoite surface antigen 2c Scaffolding_pro PF11418.3 ESA23192.1 - 0.0066 16.7 2.7 0.0066 16.7 1.9 2.1 2 0 0 2 2 2 1 Phi29 scaffolding protein TerB-N PF13208.1 ESA23192.1 - 0.15 11.4 0.5 0.2 11.0 0.3 1.3 1 1 0 1 1 1 0 TerB-N Lipoprotein_7 PF01540.11 ESA23192.1 - 0.27 10.2 14.3 0.45 9.5 9.9 1.3 1 0 0 1 1 1 0 Adhesin lipoprotein Baculo_PEP_C PF04513.7 ESA23192.1 - 0.27 11.0 8.4 1.7 8.4 5.8 2.0 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Nsp1_C PF05064.8 ESA23192.1 - 0.36 10.4 6.7 0.49 10.0 0.6 2.2 2 0 0 2 2 2 0 Nsp1-like C-terminal region Jnk-SapK_ap_N PF09744.4 ESA23192.1 - 0.48 10.3 13.4 0.27 11.2 1.4 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMF_TATA_bd PF12325.3 ESA23192.1 - 0.54 9.9 8.4 0.16 11.7 0.7 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding IFT57 PF10498.4 ESA23192.1 - 0.7 8.5 12.7 0.75 8.4 0.7 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Laminin_II PF06009.7 ESA23192.1 - 0.76 9.5 8.6 0.89 9.3 0.3 2.4 1 1 0 2 2 2 0 Laminin Domain II CDC37_N PF03234.9 ESA23192.1 - 0.95 9.7 9.9 1.4 9.2 6.9 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding APG6 PF04111.7 ESA23192.1 - 1.3 8.0 12.9 0.53 9.2 3.7 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 TMPIT PF07851.8 ESA23192.1 - 1.4 7.9 6.2 0.51 9.3 1.7 1.8 1 1 1 2 2 2 0 TMPIT-like protein FliD_C PF07195.7 ESA23192.1 - 1.7 7.9 11.2 0.93 8.7 2.4 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus TPR_MLP1_2 PF07926.7 ESA23192.1 - 2 8.1 12.0 6.7 6.4 8.3 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein LAGLIDADG_1 PF00961.14 ESA23192.1 - 7.2 7.2 8.4 6.9 7.2 0.5 2.2 1 1 1 2 2 2 0 LAGLIDADG endonuclease FMO-like PF00743.14 ESA23196.1 - 5.7e-76 255.8 0.0 7.5e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 ESA23196.1 - 2.7e-12 47.1 0.0 5.6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 ESA23196.1 - 1.7e-08 33.7 0.0 2.1e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 ESA23196.1 - 0.0038 17.6 0.0 0.0088 16.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Phage_head_chap PF11113.3 ESA23196.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Head assembly gene product Pyr_redox_2 PF07992.9 ESA23196.1 - 0.14 12.0 0.0 0.59 9.9 0.0 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_M17_N PF02789.12 ESA23196.1 - 0.17 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain Mqo PF06039.10 ESA23196.1 - 0.18 9.9 0.0 0.33 9.0 0.0 1.3 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) 7tm_1 PF00001.16 ESA23197.1 - 1e-06 28.1 10.8 4.7e-06 25.9 7.5 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.1 ESA23197.1 - 0.11 12.2 13.1 0.1 12.3 1.7 2.7 3 0 0 3 3 3 0 Olfactory receptor OAD_gamma PF04277.8 ESA23197.1 - 0.36 11.2 3.9 1.8 8.9 0.4 2.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain FUN14 PF04930.10 ESA23197.1 - 4 7.7 7.8 0.099 12.9 0.6 1.9 3 0 0 3 3 3 0 FUN14 family CytB6-F_Fe-S PF08802.5 ESA23197.1 - 4 7.5 6.0 4.4 7.3 0.6 2.5 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit MACPF PF01823.14 ESA23200.1 - 1.4e-07 31.4 2.6 1.4e-07 31.4 1.8 2.0 2 0 0 2 2 2 1 MAC/Perforin domain DUF863 PF05904.6 ESA23201.1 - 0.22 9.7 4.5 0.24 9.6 3.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Baculo_LEF5 PF04838.7 ESA23203.1 - 0.0011 18.6 0.1 0.0013 18.5 0.1 1.0 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 MipZ PF09140.6 ESA23203.1 - 0.033 13.2 0.0 0.036 13.1 0.0 1.0 1 0 0 1 1 1 0 ATPase MipZ Pkinase_Tyr PF07714.12 ESA23205.1 - 1.5e-50 171.6 0.0 1.8e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23205.1 - 2.3e-47 161.3 0.0 2.9e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA23205.1 - 0.00084 18.3 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA23205.1 - 0.0036 16.3 0.0 0.0047 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23205.1 - 0.0043 16.8 0.0 0.0077 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA23205.1 - 0.0052 16.0 0.1 0.0082 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.17 ESA23205.1 - 0.027 13.8 0.1 0.052 12.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family TAFH PF07531.9 ESA23205.1 - 0.067 12.8 0.0 0.27 10.8 0.0 2.0 1 1 1 2 2 2 0 NHR1 homology to TAF F-box-like PF12937.2 ESA23206.1 - 6.3e-06 25.8 1.4 6.3e-06 25.8 0.9 2.2 2 0 0 2 2 2 1 F-box-like DUF3294 PF07957.6 ESA23207.1 - 5.7e-05 22.7 3.4 0.00015 21.4 1.9 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3294) Poty_PP PF08440.5 ESA23207.1 - 0.00014 21.0 4.5 0.00016 20.8 3.1 1.1 1 0 0 1 1 1 1 Potyviridae polyprotein Reo_sigmaC PF04582.7 ESA23207.1 - 0.0086 15.2 1.5 0.011 14.9 1.0 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Spc24 PF08286.6 ESA23207.1 - 0.045 13.4 1.8 0.077 12.7 1.3 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 IncA PF04156.9 ESA23207.1 - 0.055 13.0 1.3 0.077 12.5 0.9 1.1 1 0 0 1 1 1 0 IncA protein DUF1664 PF07889.7 ESA23207.1 - 0.057 13.2 4.4 0.095 12.5 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Allexi_40kDa PF05549.6 ESA23207.1 - 0.062 12.5 4.4 0.085 12.1 3.0 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF724 PF05266.9 ESA23207.1 - 0.063 12.8 4.5 0.087 12.4 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ALMT PF11744.3 ESA23207.1 - 0.081 11.5 2.6 0.092 11.3 1.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Cob_adeno_trans PF01923.13 ESA23207.1 - 0.12 12.1 2.5 0.19 11.4 1.8 1.4 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Ly49 PF08391.5 ESA23207.1 - 0.19 11.8 6.9 0.3 11.2 4.8 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF342 PF03961.8 ESA23207.1 - 0.31 9.4 4.9 0.39 9.0 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Tweety PF04906.8 ESA23207.1 - 0.35 9.2 7.0 0.47 8.8 4.9 1.2 1 0 0 1 1 1 0 Tweety MetW PF07021.7 ESA23207.1 - 0.45 9.8 4.0 1 8.7 2.6 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW THOC7 PF05615.8 ESA23207.1 - 0.48 10.6 5.0 0.74 10.0 3.5 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 DUF972 PF06156.8 ESA23207.1 - 0.94 9.8 9.3 0.75 10.1 4.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DASH_Dam1 PF08653.5 ESA23207.1 - 0.98 9.2 9.7 0.57 9.9 4.4 2.4 2 1 1 3 3 2 0 DASH complex subunit Dam1 DUF720 PF05302.6 ESA23207.1 - 3.9 7.2 30.2 6 6.6 20.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF720) Pkinase PF00069.20 ESA23209.1 - 3.3e-22 78.8 0.0 3.5e-22 78.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23209.1 - 2.9e-21 75.7 0.0 3.2e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA23209.1 - 0.0032 17.2 0.1 0.0048 16.6 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA23209.1 - 0.0088 15.0 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA23209.1 - 0.011 14.7 0.0 0.015 14.3 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 ESA23210.1 - 5.3e-06 25.7 0.1 8.5e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23210.1 - 7.2e-06 25.2 0.0 1.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF904 PF06005.7 ESA23210.1 - 0.0027 17.9 2.0 0.0027 17.9 1.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF904) ADIP PF11559.3 ESA23210.1 - 0.0069 16.2 3.0 0.015 15.1 2.1 1.5 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.6 ESA23210.1 - 0.013 15.2 1.8 0.07 12.8 0.8 2.2 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region TSC22 PF01166.13 ESA23210.1 - 0.024 14.5 1.5 0.024 14.5 1.1 3.0 3 1 1 4 4 4 0 TSC-22/dip/bun family Tropomyosin_1 PF12718.2 ESA23210.1 - 0.024 14.4 2.8 0.073 12.9 2.0 1.8 1 0 0 1 1 1 0 Tropomyosin like CENP-F_leu_zip PF10473.4 ESA23210.1 - 0.03 14.1 3.3 0.091 12.6 2.3 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 ESA23210.1 - 0.039 14.3 4.9 0.06 13.6 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TBPIP PF07106.8 ESA23210.1 - 0.059 12.9 5.8 0.052 13.0 1.6 2.4 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) MA3 PF02847.12 ESA23210.1 - 0.086 12.5 0.0 0.24 11.1 0.0 1.7 1 0 0 1 1 1 0 MA3 domain DUF2968 PF11180.3 ESA23210.1 - 0.091 12.1 0.7 0.16 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF3552 PF12072.3 ESA23210.1 - 0.1 11.8 3.7 0.23 10.6 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) GAS PF13851.1 ESA23210.1 - 0.14 11.2 4.4 0.46 9.6 1.3 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 ESA23210.1 - 0.14 11.6 5.5 0.3 10.6 1.0 2.2 2 0 0 2 2 2 0 IncA protein bZIP_2 PF07716.10 ESA23210.1 - 0.22 11.3 5.0 4.4 7.2 2.5 2.5 1 1 1 2 2 2 0 Basic region leucine zipper DivIC PF04977.10 ESA23210.1 - 0.26 10.7 4.8 0.33 10.4 1.9 2.2 2 0 0 2 2 2 0 Septum formation initiator FlaC_arch PF05377.6 ESA23210.1 - 0.48 10.3 4.6 0.17 11.7 0.8 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) M PF02370.11 ESA23210.1 - 2.1 8.9 6.2 28 5.5 2.1 2.9 1 1 2 3 3 3 0 M protein repeat bZIP_1 PF00170.16 ESA23210.1 - 4.6 7.2 7.7 1.6 8.7 2.7 2.3 2 1 0 2 2 2 0 bZIP transcription factor Striatin PF08232.7 ESA23210.1 - 5.3 7.3 7.7 9.7 6.5 4.4 2.3 2 1 0 2 2 2 0 Striatin family Pkinase_Tyr PF07714.12 ESA23211.1 - 1e-28 100.1 0.0 1.2e-28 99.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23211.1 - 2.7e-27 95.5 0.0 3.1e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23211.1 - 0.0026 16.8 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23211.1 - 0.0034 17.1 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA23211.1 - 0.032 13.5 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 ESA23211.1 - 0.07 12.0 0.0 0.084 11.8 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Sel1 PF08238.7 ESA23212.1 - 1.4e-13 50.9 0.1 1.7e-09 37.9 0.0 2.0 2 0 0 2 2 2 2 Sel1 repeat TPR_1 PF00515.23 ESA23212.1 - 0.014 14.9 1.8 1.7 8.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA23212.1 - 0.016 14.8 0.1 0.034 13.7 0.0 1.6 1 1 0 1 1 1 0 TPR repeat TPR_6 PF13174.1 ESA23212.1 - 0.029 14.8 0.0 0.77 10.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 ESA23212.1 - 0.048 13.6 0.3 1.7 8.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MAP1B_neuraxin PF00414.12 ESA23212.1 - 0.094 12.0 4.0 2.9 7.4 0.3 2.3 2 0 0 2 2 2 0 Neuraxin and MAP1B repeat YfzA PF14118.1 ESA23215.1 - 0.094 12.8 8.6 3.5 7.8 3.1 2.7 1 1 1 2 2 2 0 YfzA-like protein DUF1469 PF07332.6 ESA23215.1 - 0.81 9.4 6.5 1.3 8.7 1.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1469) Microcin PF03526.8 ESA23216.1 - 0.053 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein DIX PF00778.12 ESA23217.1 - 0.084 12.5 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 DIX domain DNA_pol_B PF00136.16 ESA23218.1 - 1.9e-71 241.2 0.2 6e-71 239.6 0.2 1.7 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 ESA23218.1 - 1.1e-16 60.6 1.9 2.1e-16 59.7 1.3 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF2956 PF11169.3 ESA23219.1 - 0.027 14.4 1.6 0.027 14.4 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) BTV_NS2 PF04514.7 ESA23219.1 - 0.18 10.6 14.3 0.22 10.3 9.9 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Vfa1 PF08432.5 ESA23219.1 - 0.21 11.5 14.2 0.27 11.2 9.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 UPF0139 PF03669.8 ESA23219.1 - 0.3 10.6 0.1 0.3 10.6 0.0 1.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0139) NPR3 PF03666.8 ESA23219.1 - 0.33 9.4 9.6 0.43 9.0 6.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.1 ESA23219.1 - 0.49 9.8 16.8 0.69 9.3 11.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Rgp1 PF08737.5 ESA23219.1 - 0.58 9.1 7.8 0.64 9.0 5.4 1.2 1 0 0 1 1 1 0 Rgp1 Borrelia_P83 PF05262.6 ESA23219.1 - 0.75 7.9 11.9 0.76 7.9 8.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SOBP PF15279.1 ESA23219.1 - 1.3 9.3 4.9 1.6 9.0 3.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein MIP-T3 PF10243.4 ESA23219.1 - 1.4 7.2 26.4 1.7 7.0 18.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Zip PF02535.17 ESA23219.1 - 1.7 7.6 4.0 1.9 7.4 2.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ycf1 PF05758.7 ESA23219.1 - 2.2 5.9 15.1 2.6 5.6 10.5 1.1 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 ESA23219.1 - 8.4 3.9 12.3 9.2 3.7 8.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pkinase_Tyr PF07714.12 ESA23222.1 - 4.5e-32 111.1 0.0 5.5e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23222.1 - 5.5e-25 87.9 0.0 7.4e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain AMP-binding PF00501.23 ESA23222.1 - 0.15 10.4 0.0 0.2 9.9 0.0 1.1 1 0 0 1 1 1 0 AMP-binding enzyme zf-B_box PF00643.19 ESA23223.1 - 0.054 13.3 3.4 0.21 11.5 0.6 2.2 2 0 0 2 2 2 0 B-box zinc finger Stc1 PF12898.2 ESA23223.1 - 0.4 10.7 4.9 11 6.1 3.4 2.2 1 1 0 1 1 1 0 Stc1 domain Lipase_GDSL_3 PF14606.1 ESA23224.1 - 0.15 11.8 0.8 0.2 11.3 0.6 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF1542 PF07564.6 ESA23226.1 - 0.011 15.6 5.8 0.011 15.6 4.0 2.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) DUF309 PF03745.9 ESA23226.1 - 0.036 13.5 0.1 0.066 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF309) HHH_4 PF14490.1 ESA23226.1 - 0.069 12.9 0.7 1.2 8.8 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain GA PF01468.12 ESA23226.1 - 0.15 12.2 3.0 0.89 9.7 1.0 2.4 2 0 0 2 2 2 0 GA module PH_10 PF15411.1 ESA23227.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain F-box PF00646.28 ESA23228.1 - 1.3e-07 31.0 0.1 3.3e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 ESA23228.1 - 0.00028 20.5 0.0 0.00072 19.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like RNA_pol_Rpb6 PF01192.17 ESA23229.1 - 3.8e-20 71.3 0.5 5e-20 70.9 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 COQ7 PF03232.8 ESA23230.1 - 2.4e-74 248.4 0.1 2.7e-74 248.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.12 ESA23230.1 - 0.0047 17.2 0.0 0.0068 16.7 0.0 1.1 1 0 0 1 1 1 1 Rubrerythrin DUF2383 PF09537.5 ESA23230.1 - 0.054 13.7 0.0 7.9 6.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) IZUMO PF15005.1 ESA23230.1 - 0.12 12.3 0.0 10 6.1 0.0 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion SPRY PF00622.23 ESA23231.1 - 3.6e-22 78.7 0.5 6e-22 78.0 0.3 1.4 1 0 0 1 1 1 1 SPRY domain Kelch_2 PF07646.10 ESA23233.1 - 4.2e-07 29.4 0.1 5.3e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.1 ESA23233.1 - 9.3e-07 28.5 0.4 0.00015 21.4 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.1 ESA23233.1 - 1.1e-05 25.2 8.7 0.016 15.1 0.0 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.1 ESA23233.1 - 3.8e-05 23.7 1.1 0.00093 19.2 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.1 ESA23233.1 - 0.00062 19.8 2.6 0.4 10.9 0.3 2.4 1 1 1 2 2 2 2 Kelch motif Glycophorin_A PF01102.13 ESA23233.1 - 0.00073 19.2 0.0 0.00098 18.8 0.0 1.2 1 0 0 1 1 1 1 Glycophorin A DUF3290 PF11694.3 ESA23233.1 - 0.0098 15.6 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3290) DUF2232 PF09991.4 ESA23233.1 - 0.029 13.3 0.1 0.042 12.8 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF3753 PF12575.3 ESA23233.1 - 0.08 12.7 0.3 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) Kelch_1 PF01344.20 ESA23233.1 - 0.6 9.6 3.4 0.88 9.1 0.7 2.2 2 0 0 2 2 2 0 Kelch motif SAC3_GANP PF03399.11 ESA23234.1 - 7.1e-66 221.6 3.2 1e-65 221.1 2.2 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 ESA23234.1 - 9.9e-06 25.3 0.9 9.9e-06 25.3 0.6 1.9 2 0 0 2 2 2 1 COP9 signalosome, subunit CSN8 zf-RING_5 PF14634.1 ESA23240.1 - 3.3e-11 42.7 19.9 5.7e-05 22.7 1.5 3.5 3 0 0 3 3 3 3 zinc-RING finger domain zf-RING_2 PF13639.1 ESA23240.1 - 3.4e-08 33.1 21.4 0.0004 20.1 0.6 3.7 3 1 0 3 3 3 3 Ring finger domain zf-rbx1 PF12678.2 ESA23240.1 - 1.1e-05 25.4 9.9 0.012 15.7 0.4 3.3 3 0 0 3 3 3 2 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 ESA23240.1 - 7e-05 22.7 25.6 0.0069 16.3 1.9 4.3 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.17 ESA23240.1 - 0.012 15.3 7.6 0.67 9.7 0.0 3.8 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_UBOX PF13445.1 ESA23240.1 - 0.32 10.7 11.7 1 9.1 0.1 4.1 4 0 0 4 4 4 0 RING-type zinc-finger zf-Apc11 PF12861.2 ESA23240.1 - 0.61 9.9 11.6 2.1 8.2 0.1 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 ESA23240.1 - 1.4 8.5 24.5 0.27 10.9 2.0 3.5 3 2 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF2076 PF09849.4 ESA23241.1 - 5.2 7.0 7.5 5.9 6.8 5.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Prefoldin_3 PF13758.1 ESA23242.1 - 0.0066 16.2 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 Prefoldin subunit DUF2089 PF09862.4 ESA23242.1 - 0.017 14.8 0.2 0.023 14.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) DUF3419 PF11899.3 ESA23242.1 - 0.14 10.8 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) DUF912 PF06024.7 ESA23242.1 - 0.14 12.1 2.4 2.6 8.1 0.3 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) TMF_TATA_bd PF12325.3 ESA23243.1 - 0.066 12.9 1.5 0.067 12.9 1.1 1.0 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.10 ESA23243.1 - 2.6 7.5 5.0 5 6.6 0.6 2.0 1 1 1 2 2 2 0 Septum formation initiator 5_nucleotid_C PF02872.13 ESA23244.1 - 1.5e-31 109.4 0.5 3.2e-31 108.4 0.4 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 ESA23244.1 - 1.4e-13 50.6 1.5 2.4e-13 49.9 1.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase BTB PF00651.26 ESA23245.1 - 7e-14 51.7 0.0 2.5e-13 49.9 0.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain XAP5 PF04921.9 ESA23246.1 - 6.2e-95 317.3 9.5 6.2e-95 317.3 6.6 2.1 2 0 0 2 2 2 1 XAP5, circadian clock regulator eIF3_N PF09440.5 ESA23248.1 - 0.045 13.9 0.9 0.066 13.3 0.7 1.2 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain PDDEXK_3 PF13366.1 ESA23248.1 - 0.048 13.7 0.3 0.13 12.3 0.1 1.9 1 1 2 3 3 3 0 PD-(D/E)XK nuclease superfamily F-box-like PF12937.2 ESA23250.1 - 1.1e-05 25.0 2.3 2.8e-05 23.7 1.6 1.7 1 0 0 1 1 1 1 F-box-like CDC27 PF09507.5 ESA23251.1 - 0.017 14.4 26.4 0.019 14.1 18.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Macoilin PF09726.4 ESA23251.1 - 0.14 10.3 23.1 0.15 10.2 16.0 1.1 1 0 0 1 1 1 0 Transmembrane protein Mitofilin PF09731.4 ESA23251.1 - 0.45 9.0 17.8 0.48 9.0 12.3 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Dicty_REP PF05086.7 ESA23251.1 - 0.94 7.1 16.3 1.1 6.9 11.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_S64 PF08192.6 ESA23251.1 - 1.5 7.0 15.0 1.5 7.0 10.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF605 PF04652.11 ESA23251.1 - 1.7 7.9 22.0 1.9 7.8 15.3 1.1 1 0 0 1 1 1 0 Vta1 like Mem_trans PF03547.13 ESA23251.1 - 2.4 6.3 8.6 2.3 6.4 5.9 1.2 1 0 0 1 1 1 0 Membrane transport protein FLO_LFY PF01698.11 ESA23251.1 - 5.5 5.7 11.3 8.2 5.1 7.8 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein Glyco_transf_34 PF05637.7 ESA23252.1 - 1.1e-37 129.7 4.2 1.2e-35 123.1 2.9 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 ESA23252.1 - 0.018 14.3 0.2 0.039 13.2 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF273 Xpo1 PF08389.7 ESA23252.1 - 0.021 14.7 0.2 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Exportin 1-like protein BACK PF07707.10 ESA23253.1 - 1.8e-07 30.9 0.6 1.3e-05 24.9 0.4 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF2712 PF10916.3 ESA23253.1 - 0.083 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2712) TPR_11 PF13414.1 ESA23254.1 - 1.5e-62 207.1 35.8 9.1e-18 63.6 0.3 7.6 3 3 5 8 8 8 8 TPR repeat TPR_1 PF00515.23 ESA23254.1 - 2.6e-45 150.2 35.9 7.6e-06 25.3 0.3 11.4 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.12 ESA23254.1 - 5.4e-43 141.4 27.3 0.00029 20.5 0.2 11.5 10 1 1 11 11 11 10 Tetratricopeptide repeat TPR_17 PF13431.1 ESA23254.1 - 1e-27 93.9 16.9 0.0069 16.5 0.0 9.9 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA23254.1 - 1.1e-26 92.8 11.5 0.0016 19.0 0.0 7.6 5 2 2 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESA23254.1 - 1.6e-25 88.8 21.4 3e-05 23.8 0.1 7.4 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.1 ESA23254.1 - 2.2e-24 83.3 28.4 0.0096 15.6 0.2 10.8 9 1 1 10 10 10 8 Tetratricopeptide repeat TPR_19 PF14559.1 ESA23254.1 - 8.8e-23 80.4 17.5 2.5e-06 27.7 0.3 7.1 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA23254.1 - 7.6e-22 75.8 9.9 0.0024 18.3 0.0 9.7 4 3 6 10 10 10 4 Tetratricopeptide repeat Apc3 PF12895.2 ESA23254.1 - 1.3e-12 47.6 22.4 0.00023 21.2 2.4 5.7 2 1 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESA23254.1 - 1.5e-10 40.7 6.0 0.062 13.1 0.3 6.4 5 2 4 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.1 ESA23254.1 - 3.3e-10 38.9 15.0 0.024 14.3 0.0 9.0 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_15 PF13429.1 ESA23254.1 - 5.8e-10 38.6 5.8 8.6e-05 21.7 1.6 4.5 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA23254.1 - 5.6e-06 26.4 21.7 1.6 9.3 0.0 10.5 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_21 PF09976.4 ESA23254.1 - 9.8e-06 25.5 10.4 6.5 6.6 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.1 ESA23254.1 - 0.00086 19.3 10.5 1.7 8.7 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.1 ESA23254.1 - 0.0017 18.2 9.3 18 5.3 0.1 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat COPI_C PF06957.6 ESA23254.1 - 0.0046 15.5 0.1 0.0078 14.7 0.1 1.3 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus DUF3856 PF12968.2 ESA23254.1 - 0.0077 16.0 6.5 17 5.1 0.0 5.8 5 3 0 5 5 5 0 Domain of Unknown Function (DUF3856) SHNi-TPR PF10516.4 ESA23254.1 - 0.057 12.6 7.0 4.7 6.5 0.0 5.8 7 0 0 7 7 7 0 SHNi-TPR MIT PF04212.13 ESA23254.1 - 0.08 12.8 12.7 1.1 9.1 0.0 5.7 7 1 0 7 7 6 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.1 ESA23254.1 - 1.2 9.0 9.4 9.9 6.1 0.0 4.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat HEPN PF05168.9 ESA23254.1 - 3 7.7 9.7 1.5 8.6 0.5 4.0 3 2 1 4 4 4 0 HEPN domain TMEM51 PF15345.1 ESA23255.1 - 2.7 7.6 8.2 3.7 7.1 5.7 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Pkinase_Tyr PF07714.12 ESA23257.1 - 0.0024 17.0 0.0 1.5 7.7 0.0 2.9 3 1 0 3 3 3 2 Protein tyrosine kinase Spt5-NGN PF03439.8 ESA23257.1 - 0.039 13.6 3.0 0.28 10.9 0.1 2.5 2 0 0 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section Pkinase PF00069.20 ESA23258.1 - 4.5e-33 114.4 0.1 7.2e-33 113.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23258.1 - 1.4e-30 106.2 0.0 2.1e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.6 ESA23258.1 - 0.0039 16.4 0.2 0.0092 15.2 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) NNMT_PNMT_TEMT PF01234.12 ESA23258.1 - 0.073 12.0 0.2 0.15 10.9 0.0 1.6 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family DUF4459 PF14673.1 ESA23259.1 - 0.078 12.6 1.6 0.39 10.4 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4459) Pkinase_Tyr PF07714.12 ESA23261.1 - 4e-45 153.8 0.0 5.1e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23261.1 - 3.4e-41 141.1 0.2 1e-40 139.5 0.1 1.8 1 1 1 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA23261.1 - 0.012 14.6 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2004 PF09406.5 ESA23261.1 - 0.028 14.4 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) YchF-GTPase_C PF06071.8 ESA23261.1 - 0.04 13.7 0.1 0.089 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF933) APH PF01636.18 ESA23261.1 - 0.049 13.3 0.1 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA23263.1 - 8.1e-05 21.8 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23263.1 - 0.0011 18.1 0.0 0.0019 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23264.1 - 2.6e-34 118.4 0.0 3.4e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23264.1 - 5e-33 114.3 0.1 7.6e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA23264.1 - 0.037 13.7 0.1 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA23265.1 - 1.3e-33 116.1 0.0 2.1e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23265.1 - 1.9e-33 115.7 0.8 2.8e-33 115.1 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 ESA23265.1 - 0.029 14.1 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIH_assoc PF08454.6 ESA23265.1 - 0.029 13.9 0.6 0.17 11.5 0.2 2.4 2 0 0 2 2 2 0 RyR and IP3R Homology associated VWA_2 PF13519.1 ESA23267.1 - 9.3e-09 35.6 0.0 1.1e-08 35.3 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 ESA23267.1 - 2.7e-05 23.9 0.0 2.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Integrin_beta PF00362.13 ESA23267.1 - 8.2e-05 21.6 0.0 0.019 13.8 0.0 2.0 2 0 0 2 2 2 2 Integrin, beta chain Med25_VWA PF11265.3 ESA23267.1 - 0.015 14.3 0.0 0.092 11.7 0.0 1.9 1 1 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A Pkinase_Tyr PF07714.12 ESA23268.1 - 1.4e-20 73.5 0.0 2e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23268.1 - 1.7e-11 43.7 0.0 2.5e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA23270.1 - 3.4e-18 65.6 6.4 1.3e-07 31.9 0.1 3.5 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.1 ESA23270.1 - 0.0032 17.8 2.1 1.3 9.6 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat GATA PF00320.22 ESA23271.1 - 1.1e-15 56.7 4.9 1.5e-15 56.1 3.4 1.2 1 0 0 1 1 1 1 GATA zinc finger ArfGap PF01412.13 ESA23271.1 - 0.0043 16.8 1.0 0.007 16.1 0.7 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.7 ESA23271.1 - 0.0088 15.3 0.1 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding DZR PF12773.2 ESA23271.1 - 1 9.2 3.9 12 5.7 1.8 2.2 1 1 1 2 2 2 0 Double zinc ribbon Nudix_N_2 PF14803.1 ESA23271.1 - 1.5 8.5 4.0 27 4.5 2.9 2.2 1 1 1 2 2 2 0 Nudix N-terminal zf-RanBP PF00641.13 ESA23271.1 - 2.1 7.5 6.1 4.3 6.5 1.7 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others PIP5K PF01504.13 ESA23272.1 - 6.6e-50 169.5 2.3 6.6e-50 169.5 1.6 2.7 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase zf-3CxxC PF13695.1 ESA23273.1 - 4.8e-05 23.5 3.0 4.8e-05 23.5 2.1 3.7 2 2 0 3 3 3 1 Zinc-binding domain Prok-E2_E PF14462.1 ESA23273.1 - 0.24 11.0 3.2 0.14 11.7 0.6 1.7 2 0 0 2 2 2 0 Prokaryotic E2 family E AIG1 PF04548.11 ESA23274.1 - 1.5e-28 99.3 0.2 2.1e-28 98.8 0.1 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA23274.1 - 3.2e-11 43.2 0.2 5.7e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 ESA23274.1 - 7.9e-06 25.1 0.1 1.7e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SRPRB PF09439.5 ESA23274.1 - 0.00011 21.5 0.1 0.0002 20.6 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 ESA23274.1 - 0.00029 21.3 0.1 0.00029 21.3 0.1 1.8 2 0 0 2 2 2 1 Miro-like protein Dynamin_N PF00350.18 ESA23274.1 - 0.00039 20.2 7.4 0.0099 15.7 0.0 3.1 2 1 1 3 3 3 2 Dynamin family FeoB_N PF02421.13 ESA23274.1 - 0.00053 19.2 0.0 0.00087 18.5 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.7 ESA23274.1 - 0.0011 18.1 1.0 0.0016 17.6 0.1 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_23 PF13476.1 ESA23274.1 - 0.0014 19.0 6.6 0.0031 17.8 4.6 1.5 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 ESA23274.1 - 0.016 15.5 1.0 0.027 14.7 0.0 1.9 2 1 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 ESA23274.1 - 0.037 13.5 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 ESA23274.1 - 0.046 12.8 0.6 0.086 11.9 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin Gly-zipper_Omp PF13488.1 ESA23274.1 - 0.34 10.5 5.4 0.63 9.7 3.7 1.4 1 0 0 1 1 1 0 Glycine zipper Med2 PF11214.3 ESA23274.1 - 0.44 10.6 6.4 0.96 9.5 4.5 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 E1_DerP2_DerF2 PF02221.10 ESA23275.1 - 3.3e-05 24.1 0.1 5.2e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 ML domain RIO1 PF01163.17 ESA23276.1 - 0.021 14.1 0.1 0.04 13.2 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Fzo_mitofusin PF04799.8 ESA23276.1 - 0.12 11.7 0.3 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF2951 PF11166.3 ESA23276.1 - 1 9.2 6.9 0.24 11.2 2.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) XhlA PF10779.4 ESA23276.1 - 5.3 7.0 6.0 0.51 10.2 0.5 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Pkinase_Tyr PF07714.12 ESA23277.1 - 1.6e-37 129.0 0.0 2.8e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23277.1 - 2.5e-36 125.1 0.3 5.8e-36 123.9 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23277.1 - 0.0046 16.0 0.0 0.0078 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23277.1 - 0.0064 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 ESA23277.1 - 0.0064 15.4 0.1 0.013 14.5 0.1 1.6 1 1 0 1 1 1 1 Kinase-like zf-B_box PF00643.19 ESA23277.1 - 0.51 10.2 5.4 0.91 9.4 3.8 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF2108 PF09881.4 ESA23278.1 - 0.11 12.3 0.7 0.17 11.7 0.1 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2108) DUF4029 PF13221.1 ESA23278.1 - 0.18 12.1 2.5 0.27 11.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4029) Pkinase_Tyr PF07714.12 ESA23279.1 - 2.5e-14 52.9 0.4 6.6e-14 51.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23279.1 - 2.9e-09 36.4 0.1 9.2e-09 34.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain DUF4296 PF14129.1 ESA23279.1 - 0.33 11.1 4.7 0.41 10.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Pkinase_Tyr PF07714.12 ESA23280.1 - 0.00036 19.6 0.0 0.00076 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23281.1 - 7.9e-25 87.4 0.4 1.1e-24 86.9 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23281.1 - 2.1e-20 72.9 0.0 2.4e-20 72.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA23281.1 - 0.0068 16.1 0.0 0.0077 15.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA23281.1 - 0.067 12.2 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans PF00520.26 ESA23282.1 - 0.00053 19.3 9.3 0.00053 19.3 6.4 1.9 1 1 0 1 1 1 1 Ion transport protein Zip PF02535.17 ESA23282.1 - 0.069 12.1 3.1 0.12 11.3 2.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.6 ESA23282.1 - 0.22 10.8 8.6 0.43 9.9 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) PBP1_TM PF14812.1 ESA23282.1 - 0.57 10.5 4.8 1.4 9.2 3.4 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TF_Zn_Ribbon PF08271.7 ESA23285.1 - 1.2e-06 27.7 8.7 0.03 13.6 0.1 4.7 4 0 0 4 4 4 3 TFIIB zinc-binding HypA PF01155.14 ESA23285.1 - 0.00013 21.6 10.8 0.47 10.1 0.1 4.0 4 0 0 4 4 4 3 Hydrogenase expression/synthesis hypA family BCS1_N PF08740.6 ESA23285.1 - 0.00015 21.4 0.0 0.41 10.2 0.0 3.4 3 0 0 3 3 3 1 BCS1 N terminal Nup35_RRM PF05172.8 ESA23285.1 - 0.014 15.1 2.4 3.5 7.4 0.1 3.4 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PEMT PF04191.8 ESA23285.1 - 0.03 14.4 1.4 48 4.1 0.0 3.6 3 0 0 3 3 3 0 Phospholipid methyltransferase FlbD PF06289.6 ESA23285.1 - 0.086 12.2 0.5 1.7 8.0 0.1 3.2 3 0 0 3 3 3 0 Flagellar protein (FlbD) DUF3993 PF13158.1 ESA23287.1 - 1.6 8.5 5.9 9.3 6.0 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) TLD PF07534.11 ESA23288.1 - 3.9e-07 30.1 1.5 7.7e-07 29.1 1.0 1.5 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA23288.1 - 4.2e-07 29.9 3.4 1.1e-06 28.5 0.2 2.5 2 1 0 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA23288.1 - 1.4e-05 24.8 2.2 6.5e-05 22.7 0.7 2.7 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF4387 PF14330.1 ESA23288.1 - 0.041 14.2 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) NlpE PF04170.7 ESA23288.1 - 0.043 14.1 1.0 0.096 13.0 0.1 2.0 2 0 0 2 2 2 0 NlpE N-terminal domain Tnp_DNA_bind PF14706.1 ESA23294.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Transposase DNA-binding DUF3855 PF12967.2 ESA23297.1 - 0.0087 15.6 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Domain of Unknown Function with PDB structure (DUF3855) Phage_integrase PF00589.17 ESA23297.1 - 0.073 12.7 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Phage integrase family DivIC PF04977.10 ESA23300.1 - 0.0057 16.1 0.3 1.2 8.6 0.1 2.6 2 0 0 2 2 2 2 Septum formation initiator Cwf_Cwc_15 PF04889.7 ESA23301.1 - 0.014 15.1 9.7 0.014 15.1 6.7 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PAS_9 PF13426.1 ESA23301.1 - 0.042 14.2 0.9 0.074 13.4 0.6 1.4 1 0 0 1 1 1 0 PAS domain Pex14_N PF04695.8 ESA23301.1 - 0.56 10.2 2.2 0.92 9.5 1.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NOA36 PF06524.7 ESA23301.1 - 4.5 6.4 7.1 7 5.8 5.0 1.3 1 0 0 1 1 1 0 NOA36 protein BSP_II PF05432.6 ESA23301.1 - 6 6.0 16.8 0.16 11.2 5.3 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) U5_2-snRNA_bdg PF10597.4 ESA23302.1 - 1.2e-38 131.8 0.1 1.5e-38 131.5 0.1 1.1 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 AKAP28 PF14469.1 ESA23302.1 - 0.045 13.3 0.2 0.19 11.3 0.0 2.1 2 1 0 2 2 2 0 28 kDa A-kinase anchor U5_2-snRNA_bdg PF10597.4 ESA23303.1 - 5.1e-20 71.4 1.1 6.1e-20 71.2 0.8 1.1 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 BTB PF00651.26 ESA23306.1 - 2.4e-17 62.9 0.4 9.3e-17 61.0 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23306.1 - 1.6e-09 37.8 5.2 3.4e-09 36.8 3.6 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA23306.1 - 3e-05 23.7 0.3 3e-05 23.7 0.2 2.3 3 0 0 3 3 3 1 BTB And C-terminal Kelch HMG_box PF00505.14 ESA23308.1 - 1.9e-06 28.0 1.9 3.6e-06 27.1 0.4 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23308.1 - 0.00021 21.5 0.4 0.00021 21.5 0.3 1.8 2 0 0 2 2 2 1 HMG-box domain DUF3284 PF11687.3 ESA23308.1 - 0.022 14.4 1.2 0.044 13.5 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3284) DUF261 PF03196.8 ESA23309.1 - 0.015 15.2 0.7 0.03 14.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF261 RasGAP PF00616.14 ESA23310.1 - 2e-56 190.7 0.2 2e-56 190.7 0.1 2.5 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.10 ESA23310.1 - 1.3e-35 122.1 3.0 1.3e-35 122.1 2.1 2.4 3 0 0 3 3 3 1 RasGAP C-terminus DUF972 PF06156.8 ESA23310.1 - 0.045 14.0 9.7 0.17 12.2 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF972) KxDL PF10241.4 ESA23310.1 - 0.065 13.1 2.7 1.2 9.0 0.2 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein ACCA PF03255.9 ESA23310.1 - 0.46 10.0 7.3 1.4 8.4 0.1 3.1 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MitMem_reg PF13012.1 ESA23310.1 - 0.6 10.2 11.9 0.13 12.3 0.9 3.2 3 1 0 3 3 3 0 Maintenance of mitochondrial structure and function Dimer_Tnp_hAT PF05699.9 ESA23311.1 - 8.4e-14 50.9 0.2 9e-14 50.8 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF1014 PF06244.7 ESA23312.1 - 6.3e-10 39.3 2.4 6.6e-10 39.2 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) YABBY PF04690.8 ESA23312.1 - 3.8e-09 37.0 1.0 4.2e-09 36.8 0.7 1.0 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.14 ESA23312.1 - 1e-08 35.3 1.4 1.3e-08 35.0 1.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23312.1 - 2.3e-05 24.6 0.6 2.7e-05 24.4 0.4 1.2 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.7 ESA23312.1 - 0.14 11.8 0.8 0.19 11.4 0.5 1.2 1 0 0 1 1 1 0 CHDNT (NUC034) domain RRM_1 PF00076.17 ESA23313.1 - 2.2e-24 84.8 0.0 6.5e-16 57.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA23313.1 - 9.1e-12 44.7 0.0 7.5e-07 29.0 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA23313.1 - 1.4e-06 28.0 0.0 1.3e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF663 PF04950.7 ESA23313.1 - 0.1 11.5 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF663) zf-FPG_IleRS PF06827.9 ESA23317.1 - 0.022 14.3 0.1 0.052 13.1 0.1 1.7 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Pkinase_Tyr PF07714.12 ESA23320.1 - 3.4e-22 78.7 0.0 1.1e-15 57.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA23320.1 - 8.1e-20 71.0 0.6 1.2e-16 60.6 0.3 2.2 1 1 1 2 2 2 2 Protein kinase domain Kdo PF06293.9 ESA23320.1 - 0.002 17.2 0.1 0.0033 16.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23320.1 - 0.0067 16.1 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Malectin PF11721.3 ESA23320.1 - 0.066 12.9 0.3 0.17 11.6 0.1 1.8 2 0 0 2 2 2 0 Di-glucose binding within endoplasmic reticulum Alginate_lyase PF05426.7 ESA23320.1 - 0.12 11.7 0.1 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Alginate lyase PUL PF08324.6 ESA23321.1 - 0.0067 15.2 0.1 0.016 14.0 0.0 1.6 1 1 0 1 1 1 1 PUL domain Dimer_Tnp_hAT PF05699.9 ESA23322.1 - 3.7e-13 48.8 0.0 4.4e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Pkinase_Tyr PF07714.12 ESA23323.1 - 8.7e-17 61.0 0.0 1.3e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23323.1 - 2.3e-15 56.4 0.0 3.6e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF3087 PF11286.3 ESA23323.1 - 0.056 12.6 0.2 0.094 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) Pkinase_Tyr PF07714.12 ESA23324.1 - 4.6e-18 65.2 0.0 6e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23324.1 - 2.9e-14 52.8 0.0 3.5e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23325.1 - 8e-45 152.9 0.0 1.1e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23325.1 - 2.9e-43 147.9 0.2 5e-43 147.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 ESA23326.1 - 3.1e-31 108.4 1.0 3.2e-31 108.4 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23326.1 - 7.9e-30 103.7 0.1 8.4e-30 103.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2004 PF09406.5 ESA23326.1 - 0.043 13.8 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) APH PF01636.18 ESA23326.1 - 0.085 12.5 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA23327.1 - 6.6e-47 159.7 0.0 9.5e-47 159.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23327.1 - 1.5e-41 142.2 0.2 5.2e-41 140.5 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA23327.1 - 0.022 14.5 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Imm25 PF15571.1 ESA23327.1 - 1 9.5 6.5 0.46 10.5 0.3 2.9 3 0 0 3 3 3 0 Immunity protein 25 Baculo_PEP_C PF04513.7 ESA23328.1 - 0.018 14.9 1.3 0.026 14.3 0.9 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF755 PF05501.6 ESA23328.1 - 0.073 13.1 6.7 0.087 12.8 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) SSP160 PF06933.6 ESA23328.1 - 0.083 10.8 6.0 0.078 10.9 4.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Hemagglutinin PF00509.13 ESA23328.1 - 0.1 10.7 3.6 0.11 10.5 2.5 1.1 1 0 0 1 1 1 0 Haemagglutinin Corona_nucleoca PF00937.13 ESA23328.1 - 0.13 11.2 5.9 0.12 11.2 4.1 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein ING PF12998.2 ESA23328.1 - 0.25 11.6 2.3 0.99 9.7 1.0 1.8 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding WD40 PF00400.27 ESA23329.1 - 2e-60 198.6 25.4 1.5e-12 46.8 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 ESA23329.1 - 4.3e-13 49.4 0.2 5.8e-07 29.4 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 ESA23329.1 - 1.6e-09 36.4 3.7 0.016 13.3 0.0 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Hira PF07569.6 ESA23329.1 - 0.0011 18.2 0.2 3 6.9 0.0 3.5 3 1 0 4 4 4 1 TUP1-like enhancer of split DUF3312 PF11768.3 ESA23329.1 - 0.0015 16.8 0.0 0.0066 14.7 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3312) RicinB_lectin_2 PF14200.1 ESA23329.1 - 0.0037 17.6 0.7 0.59 10.5 0.1 3.4 1 1 3 4 4 4 2 Ricin-type beta-trefoil lectin domain-like PQQ_2 PF13360.1 ESA23329.1 - 0.018 14.4 0.0 0.082 12.3 0.0 2.0 1 1 0 1 1 1 0 PQQ-like domain DUF1513 PF07433.6 ESA23329.1 - 0.026 13.4 0.1 7.1 5.4 0.0 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1513) Kelch_6 PF13964.1 ESA23329.1 - 0.028 14.6 1.7 0.092 12.9 0.1 2.7 3 0 0 3 3 3 0 Kelch motif Cytochrom_D1 PF02239.11 ESA23329.1 - 0.064 11.5 0.0 0.25 9.5 0.0 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain LT-IIB PF06453.6 ESA23329.1 - 0.11 12.1 0.1 0.4 10.3 0.0 2.0 2 0 0 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) VID27 PF08553.5 ESA23329.1 - 0.13 10.4 0.0 0.23 9.6 0.0 1.3 1 1 0 1 1 1 0 VID27 cytoplasmic protein WD40 PF00400.27 ESA23330.1 - 1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat PEX11 PF05648.9 ESA23331.1 - 4.8e-63 212.4 4.0 5.4e-63 212.2 2.8 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) CHD5 PF04420.9 ESA23331.1 - 0.014 15.0 0.2 0.037 13.6 0.1 1.7 2 0 0 2 2 2 0 CHD5-like protein DUF4327 PF14217.1 ESA23331.1 - 0.075 12.8 0.1 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4327) Kinesin PF00225.18 ESA23332.1 - 5.1e-104 347.5 0.1 5.1e-104 347.5 0.1 2.4 2 1 0 2 2 2 1 Kinesin motor domain Ead_Ea22 PF13935.1 ESA23332.1 - 0.33 11.2 10.1 1.1 9.5 7.0 2.0 1 1 0 1 1 1 0 Ead/Ea22-like protein Pkinase_Tyr PF07714.12 ESA23333.1 - 1e-21 77.2 0.0 1.3e-21 76.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23333.1 - 6e-20 71.4 0.1 7.1e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA23334.1 - 0.00017 22.1 8.0 0.065 13.8 1.0 3.0 3 0 0 3 3 3 2 Sel1 repeat Cas_Cas02710 PF09670.5 ESA23334.1 - 0.0081 14.8 0.4 0.0093 14.6 0.3 1.2 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas02710) PPR_2 PF13041.1 ESA23334.1 - 0.044 13.7 0.1 0.13 12.2 0.1 1.8 1 1 0 1 1 1 0 PPR repeat family Sel1 PF08238.7 ESA23335.1 - 4.3e-08 33.5 1.6 0.13 12.9 0.1 3.7 4 0 0 4 4 4 3 Sel1 repeat Methyltransf_11 PF08241.7 ESA23336.1 - 1.8e-12 47.6 0.0 2.5e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA23336.1 - 2.1e-10 40.5 0.0 2.7e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA23336.1 - 4.2e-09 36.1 0.0 1.9e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA23336.1 - 1e-06 28.0 0.0 1.4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 ESA23336.1 - 1.2e-06 28.7 0.0 2.2e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA23336.1 - 1.5e-06 28.5 0.0 2.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23336.1 - 6.2e-06 26.7 0.0 1.3e-05 25.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA23336.1 - 0.00077 19.4 0.0 0.0017 18.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 ESA23336.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.15 ESA23336.1 - 0.0028 16.7 0.2 0.0078 15.3 0.1 1.8 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.12 ESA23336.1 - 0.0036 16.3 0.0 0.0084 15.1 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.10 ESA23336.1 - 0.016 14.8 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_29 PF03141.11 ESA23336.1 - 0.032 12.5 0.3 0.19 10.0 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.7 ESA23336.1 - 0.061 12.6 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.9 ESA23336.1 - 0.093 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CsbD PF05532.7 ESA23337.1 - 1.1e-20 73.0 23.9 2.9e-11 42.8 7.4 2.0 1 1 1 2 2 2 2 CsbD-like DUF3659 PF12396.3 ESA23337.1 - 4.1 7.1 6.1 3.1 7.5 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3659) Acyl_transf_1 PF00698.16 ESA23338.1 - 9.3e-29 100.7 0.0 1.3e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Acyl transferase domain DUF4581 PF15167.1 ESA23339.1 - 0.092 12.6 0.5 0.16 11.8 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4581) Rubredoxin PF00301.15 ESA23339.1 - 0.1 12.4 0.2 0.34 10.8 0.1 2.0 2 0 0 2 2 2 0 Rubredoxin Dimer_Tnp_hAT PF05699.9 ESA23340.1 - 7e-21 73.6 0.0 8.6e-21 73.3 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region p450 PF00067.17 ESA23341.1 - 2.9e-39 134.8 0.1 5.2e-39 134.0 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Glyco_hydro_88 PF07470.8 ESA23342.1 - 0.073 12.0 0.0 0.096 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 Vps51 PF08700.6 ESA23342.1 - 0.11 12.2 1.3 0.15 11.8 0.9 1.4 1 0 0 1 1 1 0 Vps51/Vps67 HA2 PF04408.18 ESA23343.1 - 9.4e-20 70.5 0.0 8e-19 67.5 0.0 2.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 ESA23343.1 - 3e-19 68.9 0.0 7.5e-19 67.6 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 ESA23343.1 - 3.4e-13 49.2 0.1 1.5e-12 47.2 0.1 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA23343.1 - 1.1e-08 34.7 0.0 4.8e-08 32.6 0.0 2.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 ESA23343.1 - 0.0015 17.5 0.1 0.0046 15.9 0.1 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 ESA23343.1 - 0.0023 18.0 0.1 0.0023 18.0 0.1 3.7 5 0 0 5 5 5 1 AAA domain ABC_tran PF00005.22 ESA23343.1 - 0.046 14.0 0.0 0.046 14.0 0.0 3.4 4 1 0 4 4 4 0 ABC transporter AAA_23 PF13476.1 ESA23343.1 - 0.093 13.0 0.1 0.093 13.0 0.0 6.5 3 1 0 4 4 4 0 AAA domain Piwi PF02171.12 ESA23344.1 - 3.9e-93 311.7 0.0 9.8e-93 310.4 0.0 1.7 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA23344.1 - 1.9e-24 85.4 0.2 4.2e-24 84.3 0.1 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA23344.1 - 7.1e-06 25.2 0.0 1.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) DUF2961 PF11175.3 ESA23344.1 - 0.12 11.6 0.1 13 4.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2961) VirDNA-topo-I_N PF09266.5 ESA23345.1 - 0.025 14.4 0.1 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal Sec1 PF00995.18 ESA23345.1 - 0.047 12.3 0.0 0.055 12.0 0.0 1.0 1 0 0 1 1 1 0 Sec1 family Transgly PF00912.17 ESA23346.1 - 0.065 12.5 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Transglycosylase AnfG_VnfG PF03139.10 ESA23346.1 - 0.15 11.8 6.1 5.6 6.7 0.1 3.6 3 0 0 3 3 3 0 Vanadium/alternative nitrogenase delta subunit Phage_H_T_join PF05521.6 ESA23346.1 - 0.43 10.8 5.9 55 4.1 0.0 3.5 3 0 0 3 3 3 0 Phage head-tail joining protein S6PP_C PF08472.5 ESA23346.1 - 0.55 9.8 9.5 1.6 8.3 0.3 3.3 3 1 0 3 3 3 0 Sucrose-6-phosphate phosphohydrolase C-terminal Cyc-maltodext_C PF10438.4 ESA23346.1 - 4.4 7.4 11.9 0.3 11.1 0.2 3.6 3 1 1 4 4 4 0 Cyclo-malto-dextrinase C-terminal domain Sel1 PF08238.7 ESA23347.1 - 3.5e-51 170.5 23.3 7.4e-13 48.6 0.1 8.6 9 0 0 9 9 9 7 Sel1 repeat TPR_6 PF13174.1 ESA23347.1 - 8.8e-06 25.8 5.6 0.38 11.2 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA23347.1 - 8.1e-05 22.1 13.1 4.7 6.9 0.0 5.7 4 1 2 6 6 6 4 TPR repeat MIT PF04212.13 ESA23347.1 - 0.061 13.2 3.0 1 9.2 0.1 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.1 ESA23347.1 - 0.11 12.8 8.4 1.9 8.9 0.0 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat SAB PF04382.8 ESA23348.1 - 0.059 13.0 0.9 0.32 10.7 0.3 2.5 2 0 0 2 2 2 0 SAB domain zf-ribbon_3 PF13248.1 ESA23348.1 - 0.078 12.2 2.0 0.26 10.5 1.4 1.9 1 0 0 1 1 1 0 zinc-ribbon domain DUF3797 PF12677.2 ESA23348.1 - 0.18 11.4 5.9 3.9 7.1 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Brr6_like_C_C PF10104.4 ESA23349.1 - 6e-37 126.1 2.5 8.3e-37 125.7 1.8 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DUF2768 PF10966.3 ESA23349.1 - 0.064 13.3 1.6 0.42 10.7 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) HHH_3 PF12836.2 ESA23350.1 - 0.056 13.3 0.4 0.092 12.7 0.0 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif TPR_11 PF13414.1 ESA23352.1 - 1e-27 95.5 51.1 4.4e-08 32.6 0.7 5.7 1 1 6 7 7 7 6 TPR repeat TPR_2 PF07719.12 ESA23352.1 - 5.3e-23 79.0 25.7 0.0021 17.8 0.1 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.23 ESA23352.1 - 2.1e-12 46.1 43.8 0.00093 18.7 0.2 7.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 ESA23352.1 - 2.6e-11 43.2 17.0 0.036 13.9 0.3 5.3 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 ESA23352.1 - 5.8e-11 41.3 46.3 0.0022 17.6 0.2 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 ESA23352.1 - 1.4e-10 41.5 0.0 0.076 13.7 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 ESA23352.1 - 4.4e-08 32.7 18.4 0.08 13.1 0.0 6.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA23352.1 - 8e-07 29.3 6.4 0.074 13.3 0.4 3.9 2 1 1 4 4 4 3 Tetratricopeptide repeat SHNi-TPR PF10516.4 ESA23352.1 - 1.4e-06 27.4 0.1 0.00017 20.7 0.0 3.0 2 0 0 2 2 2 1 SHNi-TPR TPR_14 PF13428.1 ESA23352.1 - 2.3e-06 27.7 0.0 13 6.7 0.0 5.1 3 2 3 6 6 6 0 Tetratricopeptide repeat Apc3 PF12895.2 ESA23352.1 - 8.1e-06 25.8 4.4 8.1e-06 25.8 3.0 5.1 3 1 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 ESA23352.1 - 0.00014 21.6 0.0 0.0049 16.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA23352.1 - 0.00024 20.6 9.7 4.3 7.3 0.1 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA23352.1 - 0.004 17.5 4.5 65 4.3 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 ESA23352.1 - 0.0077 16.1 0.2 2.6 8.0 0.0 3.3 4 0 0 4 4 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA23352.1 - 0.06 13.2 0.5 0.06 13.2 0.3 5.0 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Ada3 PF10198.4 ESA23352.1 - 0.12 12.1 0.9 0.22 11.2 0.4 1.6 1 1 0 1 1 1 0 Histone acetyltransferases subunit 3 PSII PF00421.14 ESA23353.1 - 0.12 10.9 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Photosystem II protein BACK PF07707.10 ESA23355.1 - 5.8e-06 26.0 0.0 2.8e-05 23.9 0.1 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch TLD PF07534.11 ESA23355.1 - 0.0048 16.8 0.2 0.042 13.8 0.2 2.4 1 1 0 1 1 1 1 TLD Pkinase_Tyr PF07714.12 ESA23356.1 - 0.0034 16.4 0.2 0.014 14.5 0.1 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1870 PF08965.5 ESA23356.1 - 0.11 12.1 0.2 0.15 11.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) LRR_6 PF13516.1 ESA23357.1 - 0.086 12.9 0.8 37 4.8 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat MACPF PF01823.14 ESA23360.1 - 5.7e-05 22.9 5.3 8.8e-05 22.2 3.7 1.3 1 0 0 1 1 1 1 MAC/Perforin domain DUF1273 PF06908.6 ESA23362.1 - 0.012 15.2 0.4 0.022 14.4 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1273) Ribosomal_L19 PF01245.15 ESA23362.1 - 0.027 14.2 0.2 0.048 13.4 0.1 1.7 1 1 0 1 1 1 0 Ribosomal protein L19 Pkinase_Tyr PF07714.12 ESA23366.1 - 9.8e-41 139.5 0.0 1.3e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23366.1 - 2.8e-35 121.7 0.0 5e-35 120.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain BNR_assoc_N PF14873.1 ESA23366.1 - 0.016 14.9 0.7 0.05 13.3 0.1 1.9 2 0 0 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase STE3 PF02076.10 ESA23366.1 - 0.034 13.2 0.2 0.069 12.2 0.0 1.6 2 0 0 2 2 2 0 Pheromone A receptor DUF3504 PF12012.3 ESA23367.1 - 0.0073 16.0 0.1 0.027 14.2 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3504) Septin PF00735.13 ESA23368.1 - 2.3e-05 23.5 0.1 4.5e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Septin F-box-like PF12937.2 ESA23369.1 - 1.6e-05 24.5 0.1 2.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 F-box-like 5_nucleotid_C PF02872.13 ESA23370.1 - 1.9e-32 112.4 0.0 4.4e-32 111.2 0.0 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.23 ESA23370.1 - 4.6e-12 45.7 0.3 8.2e-12 44.9 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RNase_PH PF01138.16 ESA23371.1 - 2.4e-23 82.9 0.0 5.2e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 ESA23371.1 - 2.4e-08 33.7 0.5 5e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RPA_interact_N PF14766.1 ESA23372.1 - 0.041 13.3 0.1 0.1 12.0 0.0 1.7 1 0 0 1 1 1 0 Replication protein A interacting N-terminal DUF1638 PF07796.6 ESA23372.1 - 0.1 12.2 3.3 0.45 10.1 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1638) DUF4414 PF14377.1 ESA23372.1 - 1.3 8.9 9.4 0.16 11.8 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4414) PRCC PF10253.4 ESA23372.1 - 1.8 9.2 14.8 0.035 14.7 3.0 2.1 1 1 1 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting E_Pc_C PF06752.7 ESA23372.1 - 9.4 5.6 11.6 17 4.8 8.0 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus CD20 PF04103.10 ESA23373.1 - 0.00043 20.2 0.8 0.00065 19.6 0.6 1.3 1 0 0 1 1 1 1 CD20-like family Choline_transpo PF04515.7 ESA23373.1 - 0.0044 15.8 0.7 0.0053 15.5 0.5 1.1 1 0 0 1 1 1 1 Plasma-membrane choline transporter Na_Ala_symp PF01235.12 ESA23373.1 - 0.044 12.3 2.1 0.061 11.8 0.5 1.7 1 1 1 2 2 2 0 Sodium:alanine symporter family Tetraspannin PF00335.15 ESA23373.1 - 0.067 12.4 4.7 0.55 9.4 3.5 2.0 1 1 1 2 2 2 0 Tetraspanin family OB_NTP_bind PF07717.11 ESA23375.1 - 1.7e-26 92.2 0.1 3.2e-26 91.3 0.1 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 ESA23375.1 - 4.3e-26 90.8 0.0 8.2e-26 90.0 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 ESA23375.1 - 6.2e-12 45.2 0.0 1.2e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Tctex-1 PF03645.8 ESA23376.1 - 1.1e-24 86.2 0.2 1.6e-24 85.6 0.2 1.3 1 0 0 1 1 1 1 Tctex-1 family ECH_C PF13766.1 ESA23376.1 - 0.045 13.9 0.1 0.087 12.9 0.0 1.5 2 0 0 2 2 2 0 2-enoyl-CoA Hydratase C-terminal region Ribul_P_3_epim PF00834.14 ESA23377.1 - 4.2e-80 267.5 0.2 5e-80 267.3 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 ESA23377.1 - 0.004 16.6 0.0 0.016 14.7 0.0 1.9 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 ESA23377.1 - 0.017 14.3 0.0 0.4 9.9 0.0 2.2 2 1 0 2 2 2 0 Histidine biosynthesis protein OMPdecase PF00215.19 ESA23377.1 - 0.037 13.4 0.2 0.31 10.3 0.0 2.2 2 1 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family PcrB PF01884.12 ESA23377.1 - 0.094 11.9 0.1 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 PcrB family BolA PF01722.13 ESA23379.1 - 1.8e-29 101.5 4.1 2e-29 101.3 2.8 1.0 1 0 0 1 1 1 1 BolA-like protein Fe_dep_repr_C PF02742.10 ESA23379.1 - 0.056 13.1 0.2 0.056 13.1 0.1 1.6 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Filament PF00038.16 ESA23382.1 - 0.0049 16.3 2.9 0.0049 16.3 2.0 2.1 2 0 0 2 2 2 1 Intermediate filament protein ATG16 PF08614.6 ESA23382.1 - 0.0069 16.2 1.6 0.0069 16.2 1.1 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.7 ESA23382.1 - 0.015 15.0 2.7 0.015 15.0 1.9 2.9 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat Phasin PF05597.6 ESA23382.1 - 0.039 13.7 0.2 0.039 13.7 0.2 2.3 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Erf4 PF10256.4 ESA23382.1 - 0.04 13.7 3.0 0.12 12.2 2.0 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Tox-REase-2 PF15646.1 ESA23382.1 - 5.9 6.7 10.5 2.8 7.8 1.8 2.4 1 1 2 3 3 3 0 Restriction endonuclease fold toxin 2 DUF2149 PF09919.4 ESA23382.1 - 7.6 6.6 6.9 3 8.0 0.2 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2149) IncA PF04156.9 ESA23382.1 - 7.9 6.0 6.5 1 8.8 1.2 1.9 3 0 0 3 3 3 0 IncA protein Jiraiya PF15038.1 ESA23384.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Jiraiya VitD-bind_III PF09164.5 ESA23385.1 - 0.29 10.7 2.4 2.1 8.0 1.0 2.6 1 1 1 2 2 2 0 Vitamin D binding protein, domain III Pkinase_Tyr PF07714.12 ESA23386.1 - 2.4e-39 134.9 0.1 3.3e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23386.1 - 5.5e-33 114.2 1.7 5.5e-33 114.2 1.2 1.7 1 1 1 2 2 2 1 Protein kinase domain RIO1 PF01163.17 ESA23386.1 - 1.8e-05 24.1 0.4 1.8e-05 24.1 0.3 1.6 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA23386.1 - 4.1e-05 22.6 0.0 0.00056 18.9 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 ESA23386.1 - 0.012 14.6 0.1 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.17 ESA23387.1 - 7.2e-05 22.3 0.1 0.00011 21.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA23387.1 - 0.0014 18.5 0.0 0.0029 17.5 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA23387.1 - 0.0016 18.2 0.1 0.0081 15.9 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3684 PF12449.3 ESA23388.1 - 2.1e-76 257.4 5.0 4.6e-47 160.3 0.5 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3684) DUF3024 PF11225.3 ESA23388.1 - 0.00045 20.0 0.0 1.2 9.0 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3024) DUF261 PF03196.8 ESA23388.1 - 0.00081 19.3 4.6 0.39 10.6 0.3 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF261 E2_bind PF08825.5 ESA23388.1 - 0.0017 18.1 0.2 3.5 7.4 0.0 2.9 3 0 0 3 3 3 2 E2 binding domain PMC2NT PF08066.7 ESA23388.1 - 0.069 13.4 0.0 16 5.9 0.0 2.5 2 0 0 2 2 2 0 PMC2NT (NUC016) domain DUF3684 PF12449.3 ESA23389.1 - 4.4e-211 703.4 15.8 7.8e-144 480.7 3.9 4.2 1 1 3 4 4 4 4 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA23389.1 - 5.1e-07 29.4 0.1 1.1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 ESA23389.1 - 0.0073 16.0 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3684 PF12449.3 ESA23390.1 - 0 1052.3 30.2 3.3e-159 531.6 5.5 5.9 1 1 4 5 5 5 5 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.1 ESA23390.1 - 4.1e-07 29.7 0.0 3e-06 26.9 0.0 2.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3024 PF11225.3 ESA23390.1 - 0.023 14.5 0.6 17 5.3 0.0 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3024) Glyco_hydro_38 PF01074.17 ESA23391.1 - 7.1e-93 310.8 0.3 1.4e-92 309.8 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 ESA23391.1 - 8.6e-82 275.3 0.0 1.2e-81 274.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 ESA23391.1 - 5.2e-27 93.8 0.0 1.3e-26 92.6 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Glyco_hydro_57 PF03065.10 ESA23391.1 - 0.00059 18.8 0.0 0.0012 17.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 AIM24 PF01987.12 ESA23393.1 - 2.3e-29 102.4 0.0 9.9e-29 100.3 0.0 2.0 2 1 0 2 2 2 1 Mitochondrial biogenesis AIM24 DUF3954 PF13128.1 ESA23393.1 - 0.11 11.8 0.1 0.63 9.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) Pyridox_oxase_2 PF12766.2 ESA23394.1 - 4.5e-30 103.9 1.4 7.1e-30 103.2 0.2 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 ESA23394.1 - 0.00017 21.5 0.0 0.00029 20.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase MRP-L27 PF09809.4 ESA23395.1 - 1.1e-17 63.6 1.0 1.3e-17 63.4 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 NIF PF03031.13 ESA23396.1 - 1.2e-28 99.8 1.7 4.5e-28 97.8 0.1 2.4 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 ESA23396.1 - 2.8e-11 43.0 0.4 9.4e-11 41.4 0.2 2.0 1 1 1 2 2 2 1 twin BRCT domain BRCT PF00533.21 ESA23396.1 - 2.6e-06 27.4 0.1 1e-05 25.5 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Biotin_lipoyl PF00364.17 ESA23396.1 - 0.0014 18.2 0.0 0.52 9.9 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme MscL PF01741.13 ESA23397.1 - 1.5e-25 89.8 0.1 1.9e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-ribbon_3 PF13248.1 ESA23397.1 - 0.0065 15.6 2.0 0.012 14.7 1.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-BED PF02892.10 ESA23397.1 - 0.0078 15.9 0.5 0.8 9.5 0.0 2.5 2 0 0 2 2 2 1 BED zinc finger DZR PF12773.2 ESA23397.1 - 0.027 14.2 0.4 0.04 13.7 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Vma12 PF11712.3 ESA23397.1 - 0.038 13.7 0.1 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Prok-RING_1 PF14446.1 ESA23397.1 - 0.062 13.0 2.2 0.1 12.3 1.5 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zinc_ribbon_2 PF13240.1 ESA23397.1 - 0.12 11.8 1.8 0.2 11.1 1.3 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-DHHC PF01529.15 ESA23397.1 - 0.21 10.9 7.9 1.1 8.5 2.1 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase PyrI_C PF02748.10 ESA23397.1 - 0.26 10.7 2.6 0.36 10.2 0.4 2.0 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain UPF0547 PF10571.4 ESA23397.1 - 0.85 9.3 5.4 1.6 8.5 3.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-LITAF-like PF10601.4 ESA23397.1 - 4.7 7.1 6.0 0.89 9.4 1.0 2.1 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain SHQ1 PF04925.10 ESA23398.1 - 4.1e-63 212.2 3.8 8e-63 211.3 2.6 1.4 1 0 0 1 1 1 1 SHQ1 protein BLOC1_2 PF10046.4 ESA23399.1 - 8.4e-28 96.4 1.4 9.9e-28 96.1 1.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4047 PF13256.1 ESA23399.1 - 0.0082 16.0 0.8 0.015 15.2 0.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4047) IncA PF04156.9 ESA23399.1 - 0.03 13.9 0.6 0.032 13.8 0.4 1.1 1 0 0 1 1 1 0 IncA protein DUF3461 PF11944.3 ESA23399.1 - 0.031 14.1 0.4 0.038 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) T4SS PF07996.6 ESA23399.1 - 0.035 13.9 0.2 0.042 13.7 0.1 1.1 1 0 0 1 1 1 0 Type IV secretion system proteins Mga PF05043.8 ESA23399.1 - 0.081 13.2 0.1 0.17 12.1 0.1 1.6 1 1 0 1 1 1 0 Mga helix-turn-helix domain LOH1CR12 PF10158.4 ESA23399.1 - 0.089 12.5 0.2 0.14 11.9 0.1 1.3 1 1 0 1 1 1 0 Tumour suppressor protein Cor1 PF04803.7 ESA23399.1 - 0.12 12.1 1.0 0.16 11.7 0.7 1.4 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region EMG1 PF03587.9 ESA23400.1 - 4.5e-72 241.5 0.5 9.2e-72 240.5 0.0 1.7 2 0 0 2 2 2 1 EMG1/NEP1 methyltransferase RGS PF00615.14 ESA23401.1 - 2.2e-12 47.1 4.7 9.3e-11 41.8 1.2 2.6 2 1 0 2 2 2 2 Regulator of G protein signaling domain MFS_1 PF07690.11 ESA23402.1 - 3.3e-59 200.3 13.7 3.3e-59 200.3 9.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 ESA23402.1 - 9.5e-13 47.5 19.0 2.3e-09 36.3 7.0 2.9 2 1 0 3 3 3 2 Sugar (and other) transporter Myosin_head PF00063.16 ESA23403.1 - 1.5e-256 852.8 6.4 1.5e-256 852.8 4.4 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 ESA23403.1 - 7.6e-35 118.9 2.0 3e-34 117.0 1.4 2.1 1 0 0 1 1 1 1 DIL domain IQ PF00612.22 ESA23403.1 - 1.7e-14 52.0 38.7 1.6e-05 24.0 1.4 7.8 8 0 0 8 8 8 5 IQ calmodulin-binding motif AAA_22 PF13401.1 ESA23403.1 - 0.004 17.3 1.2 0.041 14.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain Myosin_N PF02736.14 ESA23403.1 - 0.0054 16.3 0.7 0.013 15.2 0.5 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Tropomyosin_1 PF12718.2 ESA23403.1 - 0.0096 15.7 18.1 0.023 14.5 11.8 2.2 1 1 0 1 1 1 1 Tropomyosin like AAA_19 PF13245.1 ESA23403.1 - 0.12 12.0 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain IncA PF04156.9 ESA23403.1 - 0.17 11.4 22.8 1.1 8.8 15.8 2.3 1 1 0 1 1 1 0 IncA protein UQ_con PF00179.21 ESA23404.1 - 4.1e-42 142.9 0.0 4.6e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA23404.1 - 0.00054 19.8 0.0 0.00064 19.6 0.0 1.4 1 0 0 1 1 1 1 RWD domain UQ_con PF00179.21 ESA23405.1 - 4.4e-28 97.4 0.0 5.2e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 ESA23405.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 RWD domain Pkinase PF00069.20 ESA23407.1 - 6.4e-21 74.6 0.0 7e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23407.1 - 3.1e-20 72.3 0.0 3.3e-20 72.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA23407.1 - 0.00025 20.1 0.0 0.00027 20.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 ESA23407.1 - 0.0081 15.4 0.1 0.0099 15.1 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.1 ESA23407.1 - 0.011 14.6 0.0 0.012 14.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA23407.1 - 0.021 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 ESA23407.1 - 0.038 13.3 0.0 0.045 13.0 0.0 1.1 1 0 0 1 1 1 0 RIO1 family AIG1 PF04548.11 ESA23408.1 - 9.7e-16 57.5 0.5 3.3e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.18 ESA23408.1 - 3.2e-09 36.7 0.2 6.6e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESA23408.1 - 5.5e-06 25.6 0.4 2.2e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region LRR_4 PF12799.2 ESA23408.1 - 1.9e-05 24.1 30.1 0.068 12.8 4.1 6.2 1 1 5 6 6 6 3 Leucine Rich repeats (2 copies) ABC_tran PF00005.22 ESA23408.1 - 0.00016 21.9 0.2 0.00054 20.2 0.0 1.9 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 ESA23408.1 - 0.00043 19.4 0.1 0.00092 18.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Recep_L_domain PF01030.19 ESA23408.1 - 0.0019 18.1 4.0 0.19 11.7 0.7 3.0 1 1 1 2 2 2 1 Receptor L domain Septin PF00735.13 ESA23408.1 - 0.002 17.2 0.4 0.0065 15.5 0.2 1.9 2 0 0 2 2 2 1 Septin AAA_18 PF13238.1 ESA23408.1 - 0.0036 17.5 0.2 0.0084 16.4 0.1 1.7 2 0 0 2 2 1 1 AAA domain T2SE PF00437.15 ESA23408.1 - 0.006 15.5 0.1 0.0097 14.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein FeoB_N PF02421.13 ESA23408.1 - 0.0061 15.8 0.2 0.012 14.8 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.17 ESA23408.1 - 0.01 15.1 0.7 0.044 13.1 0.2 2.1 2 0 0 2 2 2 0 Ras family LRR_8 PF13855.1 ESA23408.1 - 0.014 15.1 6.2 0.014 15.1 4.3 4.5 1 1 2 3 3 3 0 Leucine rich repeat DUF87 PF01935.12 ESA23408.1 - 0.022 14.5 0.2 0.2 11.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_29 PF13555.1 ESA23408.1 - 0.03 13.8 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.12 ESA23408.1 - 0.03 13.7 0.1 0.15 11.5 0.0 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein DUF3744 PF12558.3 ESA23408.1 - 0.039 14.3 3.6 2.2 8.7 0.0 3.6 1 1 2 4 4 4 0 ATP-binding cassette cobalt transporter LRR_7 PF13504.1 ESA23408.1 - 0.042 14.0 24.4 8.9 7.0 0.0 7.6 3 2 3 6 6 5 0 Leucine rich repeat AAA_17 PF13207.1 ESA23408.1 - 0.044 14.6 0.2 0.13 13.0 0.1 2.0 2 1 0 2 2 1 0 AAA domain GTP_EFTU PF00009.22 ESA23408.1 - 0.05 13.0 0.1 0.14 11.6 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 ESA23408.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 ESA23408.1 - 0.056 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.21 ESA23408.1 - 0.062 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.17 ESA23408.1 - 0.09 12.9 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase FtsK_SpoIIIE PF01580.13 ESA23408.1 - 0.096 12.1 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_5 PF07728.9 ESA23408.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) LRR_6 PF13516.1 ESA23408.1 - 4.7 7.5 26.0 2.5 8.4 0.1 6.8 3 3 2 5 5 5 0 Leucine Rich repeat DEAD PF00270.24 ESA23409.1 - 3e-43 147.2 0.1 6.5e-43 146.1 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA23409.1 - 8e-22 76.9 0.0 1.7e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 ESA23409.1 - 6.5e-21 73.6 0.2 1.2e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) SecA_DEAD PF07517.9 ESA23409.1 - 0.006 15.8 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.10 ESA23409.1 - 0.011 15.5 0.0 0.036 13.8 0.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF3015 PF11220.3 ESA23409.1 - 0.033 13.7 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) AAA_22 PF13401.1 ESA23409.1 - 0.081 13.0 1.3 0.5 10.5 0.9 2.4 2 1 0 2 2 2 0 AAA domain PBP1_TM PF14812.1 ESA23409.1 - 0.96 9.7 7.0 2.3 8.5 4.8 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3668 PF12416.3 ESA23410.1 - 3.2e-45 154.8 0.0 8.1e-45 153.5 0.0 1.7 1 0 0 1 1 1 1 Cep120 protein Proteasome PF00227.21 ESA23411.1 - 1.2e-30 106.2 0.2 1.5e-30 105.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_L18e PF00828.14 ESA23412.1 - 6.1e-25 88.0 0.3 6.1e-25 88.0 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 Methyltransf_16 PF10294.4 ESA23413.1 - 5.5e-11 42.2 0.0 0.00013 21.5 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_23 PF13489.1 ESA23413.1 - 5.8e-06 26.1 0.0 1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23413.1 - 0.00082 19.9 0.0 0.0016 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA23413.1 - 0.0012 18.4 0.0 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA23413.1 - 0.012 16.1 0.0 0.39 11.2 0.0 2.6 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 ESA23413.1 - 0.14 11.5 0.0 0.31 10.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Pkinase PF00069.20 ESA23414.1 - 1.5e-68 230.7 0.0 2.2e-68 230.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23414.1 - 4.9e-32 111.0 0.0 7.2e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 ESA23414.1 - 1.4e-08 34.7 0.1 2.9e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 ESA23414.1 - 1e-07 31.2 0.0 1.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA23414.1 - 0.073 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UBA PF00627.26 ESA23414.1 - 0.079 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain YukC PF10140.4 ESA23414.1 - 0.12 10.9 0.3 0.3 9.6 0.0 1.7 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC 2OG-FeII_Oxy_2 PF13532.1 ESA23415.1 - 1e-06 28.7 0.0 2e-06 27.7 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily La PF05383.12 ESA23416.1 - 1.4e-22 79.2 0.5 2.9e-22 78.2 0.0 1.8 2 0 0 2 2 2 1 La domain RRM_3 PF08777.6 ESA23416.1 - 1.7e-05 24.6 0.2 0.0013 18.5 0.0 2.6 2 0 0 2 2 2 1 RNA binding motif RRM_6 PF14259.1 ESA23416.1 - 2.2e-05 24.3 0.2 0.00012 21.9 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 ESA23416.1 - 4.4e-05 23.0 1.8 0.00018 21.0 0.7 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA23416.1 - 0.00029 20.6 0.4 0.0078 16.0 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tna_leader PF08053.6 ESA23417.1 - 0.15 11.4 2.6 0.5 9.8 1.8 1.9 1 0 0 1 1 1 0 Tryptophanese operon leader peptide HNH_2 PF13391.1 ESA23417.1 - 0.26 11.1 2.6 0.58 9.9 1.8 1.7 1 1 0 1 1 1 0 HNH endonuclease F-box-like PF12937.2 ESA23418.1 - 0.013 15.1 0.2 0.032 13.9 0.2 1.6 1 0 0 1 1 1 0 F-box-like STAS PF01740.16 ESA23418.1 - 0.077 12.4 0.0 0.2 11.0 0.0 1.6 1 1 1 2 2 2 0 STAS domain Laminin_G_3 PF13385.1 ESA23419.1 - 9.5e-13 48.6 0.1 1.9e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pkinase_Tyr PF07714.12 ESA23420.1 - 0.0006 18.9 0.0 0.23 10.4 0.0 2.5 2 1 1 3 3 3 2 Protein tyrosine kinase CotH PF08757.6 ESA23423.1 - 0.17 11.1 1.2 0.19 10.9 0.8 1.0 1 0 0 1 1 1 0 CotH protein zf-C2H2 PF00096.21 ESA23426.1 - 5.2e-06 26.4 13.9 0.084 13.2 1.0 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA23426.1 - 4.8e-05 23.3 14.5 0.0052 17.0 0.5 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA23426.1 - 5.3e-05 23.2 2.9 5.3e-05 23.2 2.0 4.0 4 0 0 4 4 4 1 Zinc-finger double domain Sina PF03145.11 ESA23426.1 - 0.0021 17.7 4.8 0.19 11.3 0.1 2.1 1 1 1 2 2 2 2 Seven in absentia protein family zf-Di19 PF05605.7 ESA23426.1 - 0.0053 16.8 5.8 0.042 13.9 0.8 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding CASP_C PF08172.7 ESA23428.1 - 0.0016 17.4 2.3 0.0026 16.8 1.6 1.3 1 0 0 1 1 1 1 CASP C terminal ATG16 PF08614.6 ESA23428.1 - 0.0017 18.2 5.1 0.0017 18.2 3.5 1.9 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) GAS PF13851.1 ESA23428.1 - 0.012 14.8 3.0 0.015 14.5 2.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4635 PF15466.1 ESA23428.1 - 0.027 13.7 1.0 0.072 12.3 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) Rootletin PF15035.1 ESA23428.1 - 0.028 14.3 7.0 0.026 14.5 4.1 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ADIP PF11559.3 ESA23428.1 - 0.033 14.0 6.0 0.034 14.0 3.4 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Seryl_tRNA_N PF02403.17 ESA23428.1 - 0.038 13.9 4.5 0.065 13.2 1.6 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3399 PF11879.3 ESA23428.1 - 0.039 14.1 1.7 0.04 14.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) MbeD_MobD PF04899.7 ESA23428.1 - 0.12 12.3 0.3 0.21 11.4 0.2 1.6 1 1 0 1 1 1 0 MbeD/MobD like Med4 PF10018.4 ESA23428.1 - 0.12 11.7 4.4 0.22 10.9 3.0 1.5 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Pex19 PF04614.7 ESA23428.1 - 0.14 11.7 0.7 0.29 10.6 0.4 1.5 1 1 0 1 1 1 0 Pex19 protein family Nsp1_C PF05064.8 ESA23428.1 - 0.18 11.4 2.2 0.17 11.4 0.7 1.6 2 0 0 2 2 2 0 Nsp1-like C-terminal region Syntaxin-6_N PF09177.6 ESA23428.1 - 0.19 12.1 3.5 0.78 10.1 2.4 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal MRP-S31 PF15433.1 ESA23428.1 - 0.28 10.5 3.6 0.34 10.2 2.5 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF2968 PF11180.3 ESA23428.1 - 0.51 9.6 3.5 4.1 6.7 1.8 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2968) DivIC PF04977.10 ESA23428.1 - 0.81 9.2 4.4 1.7 8.2 1.8 2.2 1 1 1 2 2 2 0 Septum formation initiator IncA PF04156.9 ESA23428.1 - 1 8.8 7.4 1.8 8.1 5.1 1.5 1 1 0 1 1 1 0 IncA protein NTR2 PF15458.1 ESA23428.1 - 1.7 7.8 9.0 0.37 9.9 3.3 1.9 1 1 1 2 2 2 0 Nineteen complex-related protein 2 HTH_29 PF13551.1 ESA23429.1 - 2.6e-05 24.3 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 ESA23429.1 - 3.5e-05 23.3 0.4 0.00022 20.7 0.0 2.3 2 1 1 3 3 3 1 Homeodomain-like domain PAX PF00292.13 ESA23429.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_Tnp_IS630 PF01710.11 ESA23429.1 - 0.0055 16.3 0.1 0.0073 15.9 0.0 1.2 1 0 0 1 1 1 1 Transposase Myb_DNA-bind_3 PF12776.2 ESA23431.1 - 9.8 6.8 10.5 1.1 9.9 2.2 2.9 1 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain LRR_4 PF12799.2 ESA23432.1 - 7e-11 41.5 26.5 1.9e-05 24.1 1.3 4.1 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 ESA23432.1 - 1.6e-06 27.7 18.8 0.00037 20.1 1.3 3.9 2 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.1 ESA23432.1 - 0.00055 19.7 22.1 6.3 7.2 0.1 6.6 2 2 1 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.28 ESA23432.1 - 0.002 17.8 23.7 1.8 8.9 0.7 7.0 4 1 2 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 ESA23432.1 - 0.013 15.5 15.5 0.18 12.1 0.7 5.9 4 2 2 6 6 6 0 Leucine rich repeat PIF1 PF05970.9 ESA23433.1 - 8.8e-17 61.0 3.0 9.3e-08 31.3 0.5 2.0 1 1 1 2 2 2 2 PIF1-like helicase Herpes_Helicase PF02689.9 ESA23434.1 - 0.023 12.4 0.0 0.027 12.2 0.0 1.1 1 0 0 1 1 1 0 Helicase DUF3455 PF11937.3 ESA23438.1 - 3.7e-13 49.7 0.0 4.7e-12 46.2 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3455) DUF1340 PF07067.6 ESA23439.1 - 0.068 12.3 0.1 0.074 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) DUF1255 PF06865.6 ESA23441.1 - 0.054 13.7 0.0 5.5 7.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1255) Pkinase_Tyr PF07714.12 ESA23442.1 - 5.7e-37 127.1 0.1 1.5e-36 125.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23442.1 - 1.3e-31 109.6 0.1 1.3e-31 109.6 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA23442.1 - 7.1e-13 48.7 12.6 0.00013 22.4 0.2 4.1 4 0 0 4 4 4 3 Sel1 repeat Kinase-like PF14531.1 ESA23442.1 - 0.0054 15.7 0.1 0.013 14.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like zf-C4H2 PF10146.4 ESA23442.1 - 0.49 10.3 7.8 0.9 9.5 5.4 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein PG_binding_4 PF12229.3 ESA23442.1 - 2 8.6 10.7 0.19 11.9 2.1 3.1 2 1 1 3 3 3 0 Putative peptidoglycan binding domain DUF3027 PF11228.3 ESA23443.1 - 0.043 13.4 0.4 0.082 12.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) AAA_5 PF07728.9 ESA23443.1 - 0.052 13.2 0.2 0.28 10.9 0.1 2.0 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) RRM_1 PF00076.17 ESA23445.1 - 8.5e-10 38.1 0.1 1.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA23445.1 - 2.1e-06 27.6 0.0 4.1e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA23445.1 - 0.0041 16.9 0.0 0.0091 15.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ECH PF00378.15 ESA23446.1 - 1.7e-23 83.0 0.0 2.2e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 ESA23446.1 - 0.019 14.7 0.0 4.3 7.1 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 WD40 PF00400.27 ESA23447.1 - 2.6e-28 96.8 18.8 5.2e-08 32.4 0.8 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat zf-C2H2 PF00096.21 ESA23448.1 - 2.8e-14 52.4 8.9 3.8e-07 30.0 1.9 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 ESA23448.1 - 7.9e-11 41.7 16.1 2.3e-07 30.7 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA23448.1 - 8.5e-10 38.2 7.8 5.7e-05 23.1 1.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.1 ESA23448.1 - 2.5e-06 27.0 2.8 0.0014 18.2 0.3 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-Di19 PF05605.7 ESA23448.1 - 3.8e-05 23.7 0.9 4.7e-05 23.4 0.6 1.2 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 ESA23448.1 - 0.00018 21.5 3.3 0.0044 17.1 0.2 2.4 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 ESA23448.1 - 0.00065 19.4 1.6 0.6 9.9 0.1 2.2 2 1 0 2 2 2 2 BED zinc finger zf-met PF12874.2 ESA23448.1 - 0.0007 19.7 2.5 0.023 14.8 0.4 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 ESA23448.1 - 0.0008 19.2 2.5 0.1 12.5 0.4 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.5 ESA23448.1 - 0.01 15.7 1.0 2 8.4 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Ogr_Delta PF04606.7 ESA23448.1 - 0.026 14.1 1.5 0.034 13.7 1.0 1.3 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger FANCL_C PF11793.3 ESA23448.1 - 0.13 12.2 2.0 2.8 7.9 0.4 2.1 2 0 0 2 2 2 0 FANCL C-terminal domain zf-C2H2_2 PF12756.2 ESA23448.1 - 0.15 12.1 0.6 1.8 8.6 0.0 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.1 ESA23448.1 - 0.46 10.8 10.2 2.9 8.3 1.7 2.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-CHCC PF10276.4 ESA23448.1 - 1.7 8.5 7.9 0.32 10.8 1.6 2.2 2 1 0 2 2 2 0 Zinc-finger domain DUF2874 PF11396.3 ESA23449.1 - 0.038 13.9 0.7 5.3 7.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) Pkinase PF00069.20 ESA23450.1 - 2.9e-08 33.2 1.4 2.9e-08 33.1 1.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23450.1 - 5.3e-08 32.2 0.4 6e-08 32.0 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 ESA23450.1 - 0.012 14.7 0.6 0.013 14.5 0.4 1.0 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23450.1 - 0.033 13.9 0.2 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA23453.1 - 2.5e-07 30.0 0.0 2.8e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23453.1 - 7.5e-05 21.9 0.0 8.9e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-MYND PF01753.13 ESA23454.1 - 1.4e-05 24.8 7.1 2.6e-05 24.0 4.9 1.5 1 0 0 1 1 1 1 MYND finger Peptidase_M24 PF00557.19 ESA23454.1 - 9.9e-05 22.0 0.0 0.00013 21.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-HIT PF04438.11 ESA23454.1 - 0.034 13.8 5.3 0.065 12.8 3.7 1.4 1 0 0 1 1 1 0 HIT zinc finger Pyr_redox_dim PF02852.17 ESA23454.1 - 0.12 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DUF4596 PF15363.1 ESA23455.1 - 0.13 12.2 0.1 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4596) DUF1912 PF08930.5 ESA23457.1 - 0.0043 17.1 0.8 4.9 7.3 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1912) MannoseP_isomer PF01050.13 ESA23457.1 - 0.008 15.8 0.2 3.1 7.4 0.0 2.3 1 1 1 2 2 2 2 Mannose-6-phosphate isomerase Sds3 PF08598.6 ESA23457.1 - 0.074 12.5 1.1 0.1 12.0 0.7 1.2 1 0 0 1 1 1 0 Sds3-like AAA_11 PF13086.1 ESA23457.1 - 0.089 12.3 0.4 0.12 11.9 0.3 1.2 1 0 0 1 1 1 0 AAA domain zf-BED PF02892.10 ESA23459.1 - 0.00088 18.9 0.5 0.0015 18.2 0.3 1.4 1 0 0 1 1 1 1 BED zinc finger SR-25 PF10500.4 ESA23459.1 - 0.0083 15.6 1.1 0.0089 15.5 0.8 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF99 PF01949.11 ESA23459.1 - 0.015 14.3 0.3 0.019 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 RabGAP-TBC PF00566.13 ESA23459.1 - 0.053 12.9 0.9 0.063 12.7 0.6 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain ATP-grasp PF02222.17 ESA23459.1 - 0.1 11.9 0.1 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp domain APG6 PF04111.7 ESA23459.1 - 1.9 7.4 7.5 2.4 7.1 5.2 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 HSBP1 PF06825.7 ESA23460.1 - 0.018 14.6 1.2 0.035 13.6 0.9 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 ACDC PF14733.1 ESA23460.1 - 2.8 8.1 5.9 10 6.3 0.3 3.1 3 0 0 3 3 3 0 AP2-coincident C-terminal Hormone_1 PF00103.15 ESA23462.1 - 0.088 12.1 0.5 0.1 11.9 0.3 1.0 1 0 0 1 1 1 0 Somatotropin hormone family F-box-like PF12937.2 ESA23465.1 - 0.0048 16.5 1.1 0.015 15.0 0.7 1.8 1 0 0 1 1 1 1 F-box-like EF-hand_4 PF12763.2 ESA23465.1 - 0.0062 16.2 0.7 2.1 8.1 0.0 2.8 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.20 ESA23466.1 - 1.1e-26 93.6 0.0 1.5e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23466.1 - 8.6e-26 90.5 0.0 1.1e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Mito_carr PF00153.22 ESA23467.1 - 1.4e-49 165.7 0.7 1.4e-23 82.4 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Drf_FH3 PF06367.11 ESA23467.1 - 0.14 11.5 0.1 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Diaphanous FH3 Domain Pkinase PF00069.20 ESA23468.1 - 3.7e-17 62.3 1.7 1e-16 60.8 0.2 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23468.1 - 5.3e-16 58.4 0.0 9.1e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA23468.1 - 0.095 12.4 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family APC10 PF03256.11 ESA23469.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) HALZ PF02183.13 ESA23470.1 - 0.00073 19.2 1.5 0.00073 19.2 1.0 3.2 3 0 0 3 3 3 1 Homeobox associated leucine zipper DUF830 PF05708.7 ESA23470.1 - 0.021 14.8 0.0 0.064 13.2 0.0 1.9 1 0 0 1 1 1 0 Orthopoxvirus protein of unknown function (DUF830) CTD PF12815.2 ESA23470.1 - 0.095 13.1 0.6 0.17 12.2 0.0 1.7 2 0 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 MbeD_MobD PF04899.7 ESA23470.1 - 0.1 12.4 4.1 0.085 12.7 0.6 2.3 2 0 0 2 2 2 0 MbeD/MobD like Pkinase_Tyr PF07714.12 ESA23472.1 - 1.6e-25 89.7 0.0 3.1e-23 82.1 0.0 3.6 4 0 0 4 4 4 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23472.1 - 2.8e-20 72.5 0.7 1.4e-19 70.3 0.4 2.3 2 1 0 2 2 2 1 Protein kinase domain Fer4_7 PF12838.2 ESA23472.1 - 0.042 14.2 4.8 20 5.6 0.0 3.9 4 0 0 4 4 4 0 4Fe-4S dicluster domain Fer4_8 PF13183.1 ESA23472.1 - 0.045 13.7 5.3 18 5.4 0.0 3.7 4 0 0 4 4 4 0 4Fe-4S dicluster domain DUF4134 PF13572.1 ESA23472.1 - 0.091 12.8 0.9 8.9 6.5 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4134) APH PF01636.18 ESA23472.1 - 0.11 12.2 0.1 0.27 10.9 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Gag_MA PF01140.14 ESA23472.1 - 2.8 7.7 8.5 5.5 6.8 0.1 4.4 4 1 1 5 5 5 0 Matrix protein (MA), p15 Fer4_9 PF13187.1 ESA23472.1 - 3.3 8.0 12.1 12 6.2 0.1 4.1 4 0 0 4 4 4 0 4Fe-4S dicluster domain DUF1160 PF06648.6 ESA23473.1 - 0.31 10.8 5.1 0.47 10.2 0.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1160) HSP20 PF00011.16 ESA23474.1 - 9.3e-25 86.4 0.1 1.2e-24 86.0 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF4097 PF13349.1 ESA23474.1 - 0.0041 16.6 0.3 0.0057 16.2 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4097) CS PF04969.11 ESA23474.1 - 0.014 15.9 0.3 0.049 14.1 0.2 1.9 1 1 0 1 1 1 0 CS domain BON PF04972.12 ESA23474.1 - 0.12 12.1 0.0 0.59 9.9 0.0 1.9 2 0 0 2 2 2 0 BON domain Pkinase_Tyr PF07714.12 ESA23476.1 - 2e-34 118.8 0.0 2.6e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23476.1 - 6.1e-34 117.3 0.0 8.3e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF1433 PF07252.6 ESA23476.1 - 0.068 13.3 0.6 4.8 7.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1433) Pkinase_Tyr PF07714.12 ESA23477.1 - 3.4e-11 42.7 0.0 1.1e-10 41.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase MHC_I PF00129.13 ESA23477.1 - 0.013 14.8 7.9 0.019 14.3 0.4 2.5 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Bystin PF05291.6 ESA23478.1 - 7.8e-18 64.4 3.0 7.8e-17 61.1 2.0 2.0 1 1 0 1 1 1 1 Bystin DUF3994 PF13159.1 ESA23478.1 - 0.094 12.9 0.5 0.12 12.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3994) DBC1 PF14443.1 ESA23478.1 - 0.099 12.1 0.2 2.8 7.4 0.1 2.1 1 1 1 2 2 2 0 DBC1 DUF896 PF05979.7 ESA23478.1 - 0.11 12.0 2.0 2.4 7.7 0.2 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) HSP70 PF00012.15 ESA23479.1 - 8e-260 862.9 14.6 9.1e-260 862.7 10.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA23479.1 - 9.7e-19 67.1 0.8 7.8e-17 60.8 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein DDR PF08841.5 ESA23479.1 - 0.0061 15.4 0.3 0.14 10.9 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.13 ESA23479.1 - 0.011 14.8 3.2 0.19 10.7 0.1 3.1 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase DUF1043 PF06295.7 ESA23479.1 - 0.17 11.5 5.5 0.3 10.7 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) FtsA PF14450.1 ESA23479.1 - 5.1 6.9 7.9 10 5.9 0.1 3.8 2 1 0 2 2 2 0 Cell division protein FtsA SAM_adeno_trans PF01887.11 ESA23480.1 - 0.0032 16.5 0.8 3.1 6.7 0.0 3.6 1 1 3 4 4 4 1 S-adenosyl-l-methionine hydroxide adenosyltransferase DUF1116 PF06545.6 ESA23480.1 - 0.011 14.8 0.6 40 3.2 0.0 5.2 5 1 1 6 6 6 0 Protein of unknown function (DUF1116) DUF3712 PF12505.3 ESA23480.1 - 0.018 15.1 2.5 1e+02 2.9 0.0 5.6 3 2 4 7 7 7 0 Protein of unknown function (DUF3712) DUF4537 PF15057.1 ESA23480.1 - 0.039 13.7 1.7 20 4.9 0.0 4.8 3 2 3 6 6 6 0 Domain of unknown function (DUF4537) DUF2996 PF11210.3 ESA23480.1 - 8 6.7 10.6 1.3e+02 2.8 0.1 4.8 3 2 1 5 5 5 0 Protein of unknown function (DUF2996) MoCF_biosynth PF00994.19 ESA23481.1 - 3.5e-32 110.7 0.0 6.7e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain Orthopox_A49R PF06489.6 ESA23481.1 - 0.013 15.4 1.7 0.075 13.0 0.4 2.3 2 0 0 2 2 2 0 Orthopoxvirus A49R protein ABC1 PF03109.11 ESA23482.1 - 1.2e-31 109.1 0.2 2e-31 108.3 0.1 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 ESA23482.1 - 0.0062 16.2 0.0 0.29 10.8 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Fzo_mitofusin PF04799.8 ESA23482.1 - 0.011 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 fzo-like conserved region ROS_MUCR PF05443.6 ESA23483.1 - 0.012 15.3 1.4 0.15 11.7 0.2 2.2 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Zn_Tnp_IS1595 PF12760.2 ESA23483.1 - 0.13 12.0 0.8 0.29 10.9 0.5 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-ISL3 PF14690.1 ESA23483.1 - 4.8 7.2 6.3 0.69 9.9 0.5 2.3 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 HCNGP PF07818.8 ESA23486.1 - 0.21 11.6 2.0 0.16 11.9 0.2 1.7 2 0 0 2 2 2 0 HCNGP-like protein Pkinase_Tyr PF07714.12 ESA23487.1 - 5.8e-18 64.8 0.0 8e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23487.1 - 1.3e-13 50.6 0.2 2.7e-13 49.6 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Stc1 PF12898.2 ESA23487.1 - 0.031 14.3 0.5 0.064 13.3 0.4 1.5 1 0 0 1 1 1 0 Stc1 domain APH PF01636.18 ESA23487.1 - 0.072 12.8 0.1 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3099 PF11298.3 ESA23488.1 - 0.05 13.3 2.4 0.054 13.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) DUF3112 PF11309.3 ESA23489.1 - 0.015 15.1 0.0 0.023 14.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) DUF3455 PF11937.3 ESA23490.1 - 1.6e-21 77.0 1.0 3.4e-15 56.4 0.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3455) HSP70 PF00012.15 ESA23491.1 - 0.12 10.3 8.0 0.11 10.3 5.5 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF576 PF04507.7 ESA23491.1 - 0.13 11.1 4.5 0.13 11.1 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF576 Hist_deacetyl PF00850.14 ESA23492.1 - 3e-96 322.3 0.7 4.4e-96 321.8 0.5 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.4 ESA23492.1 - 2.1e-20 72.9 0.0 3.3e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Arb2 domain Rep_fac-A_3 PF08661.6 ESA23493.1 - 4.2e-16 58.8 0.0 4.6e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 PapD_C PF02753.12 ESA23493.1 - 0.037 13.8 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 Pili assembly chaperone PapD, C-terminal domain CI-B14_5a PF07347.7 ESA23494.1 - 0.005 16.5 0.2 0.011 15.4 0.1 1.6 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) BolA PF01722.13 ESA23495.1 - 3.2e-21 75.0 0.0 4e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein Pkinase_Tyr PF07714.12 ESA23496.1 - 1.1e-15 57.4 0.0 1.4e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23496.1 - 1.4e-12 47.3 0.0 1.9e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA23497.1 - 4.8e-60 198.6 27.4 6e-14 52.1 1.7 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA23497.1 - 7.8e-06 26.0 11.4 1.3 9.6 0.3 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat MIT PF04212.13 ESA23497.1 - 6.7e-05 22.6 15.8 0.67 9.8 0.1 4.7 5 0 0 5 5 5 3 MIT (microtubule interacting and transport) domain PixA PF12306.3 ESA23497.1 - 0.078 12.8 2.1 6.1 6.6 0.0 2.6 1 1 2 3 3 3 0 Inclusion body protein TPR_5 PF12688.2 ESA23497.1 - 0.23 11.4 2.6 26 4.8 0.0 3.7 2 1 2 4 4 4 0 Tetratrico peptide repeat Foie-gras_1 PF11817.3 ESA23497.1 - 1.6 8.1 5.7 1e+02 2.2 3.9 2.8 1 1 0 1 1 1 0 Foie gras liver health family 1 Pkinase_Tyr PF07714.12 ESA23498.1 - 9.2e-34 116.6 0.0 1.1e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23498.1 - 1.1e-31 109.8 0.0 1.8e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA23498.1 - 0.032 13.9 0.2 0.05 13.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_Tyr PF07714.12 ESA23499.1 - 6.5e-34 117.1 0.0 8.1e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23499.1 - 3.7e-30 104.9 0.0 5.2e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23499.1 - 0.01 14.8 0.2 0.015 14.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23499.1 - 0.029 14.1 0.2 0.04 13.6 0.2 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.6 ESA23499.1 - 0.11 11.6 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA23500.1 - 1.1e-35 122.9 0.0 1.4e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23500.1 - 6.2e-33 114.0 0.0 8.4e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23500.1 - 0.012 14.6 0.2 0.017 14.1 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23500.1 - 0.014 15.1 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA23501.1 - 5.7e-53 176.1 25.8 6.6e-12 45.6 0.7 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_16 PF13432.1 ESA23501.1 - 8.7e-05 23.0 0.8 3.5 8.4 0.0 4.0 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA23501.1 - 0.0027 18.0 7.0 0.86 10.2 0.3 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat 23S_rRNA_IVP PF05635.6 ESA23501.1 - 0.0042 16.9 0.5 0.22 11.4 0.0 2.2 2 0 0 2 2 2 1 23S rRNA-intervening sequence protein MIT PF04212.13 ESA23501.1 - 0.076 12.9 9.3 4.3 7.2 0.0 4.7 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain GSu_C4xC__C2xCH PF09698.5 ESA23501.1 - 0.32 11.2 7.0 28 4.9 0.1 3.5 3 0 0 3 3 3 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) TPR_11 PF13414.1 ESA23501.1 - 0.41 10.3 21.3 6.3 6.5 3.9 4.1 1 1 3 4 4 4 0 TPR repeat Sel1 PF08238.7 ESA23502.1 - 9.8e-107 347.0 49.8 1.2e-12 48.0 0.0 11.6 12 0 0 12 12 12 11 Sel1 repeat TPR_16 PF13432.1 ESA23502.1 - 9.4e-06 26.1 1.5 8 7.2 0.0 6.0 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA23502.1 - 0.00021 21.5 12.8 9.3 6.9 0.1 8.0 9 0 0 9 9 9 2 Tetratricopeptide repeat MIT PF04212.13 ESA23502.1 - 0.1 12.5 17.3 40 4.1 0.0 8.6 9 0 0 9 9 9 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.7 ESA23503.1 - 6.3e-139 449.4 79.2 2e-11 44.1 0.7 15.6 16 0 0 16 16 16 15 Sel1 repeat GSu_C4xC__C2xCH PF09698.5 ESA23503.1 - 8.6 6.6 18.1 31 4.8 0.2 6.5 7 0 0 7 7 7 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) RRM_1 PF00076.17 ESA23504.1 - 2.6e-07 30.1 0.0 0.00038 20.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LolA PF03548.10 ESA23504.1 - 0.032 13.8 0.0 0.12 12.0 0.0 1.8 1 1 1 2 2 2 0 Outer membrane lipoprotein carrier protein LolA RRM_6 PF14259.1 ESA23504.1 - 0.04 13.8 0.0 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Gelsolin PF00626.17 ESA23506.1 - 0.05 13.3 0.1 0.13 11.9 0.1 1.7 1 0 0 1 1 1 0 Gelsolin repeat DUF3791 PF12668.2 ESA23506.1 - 0.082 12.5 0.2 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Exo_endo_phos_2 PF14529.1 ESA23507.1 - 0.022 14.3 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase WD40 PF00400.27 ESA23508.1 - 2.7e-24 84.1 0.1 2.8e-06 26.9 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat IBN_N PF03810.14 ESA23509.1 - 9.4e-15 54.2 0.1 5.1e-14 51.9 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain RIX1 PF08167.7 ESA23509.1 - 0.00064 19.4 7.5 0.43 10.2 0.0 4.6 5 1 0 5 5 5 2 rRNA processing/ribosome biogenesis HEAT_2 PF13646.1 ESA23509.1 - 0.0023 18.1 0.0 4.5 7.6 0.0 3.1 2 0 0 2 2 2 2 HEAT repeats BUD22 PF09073.5 ESA23509.1 - 0.023 13.7 8.8 0.033 13.2 6.1 1.2 1 0 0 1 1 1 0 BUD22 Vac14_Fab1_bd PF12755.2 ESA23509.1 - 0.47 10.8 5.1 2.1 8.8 0.0 4.5 4 1 2 6 6 6 0 Vacuolar 14 Fab1-binding region EcoR124_C PF12008.3 ESA23510.1 - 0.013 14.7 0.9 0.015 14.5 0.6 1.1 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal DUF4218 PF13960.1 ESA23511.1 - 6.1e-06 25.7 0.3 7.3e-06 25.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) Pkinase PF00069.20 ESA23512.1 - 0.00019 20.6 0.0 0.00019 20.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23512.1 - 0.016 14.2 0.1 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase DUF1335 PF07056.6 ESA23514.1 - 0.021 14.5 0.1 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) RVT_1 PF00078.22 ESA23514.1 - 0.024 14.0 0.1 0.042 13.1 0.1 1.4 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4379 PF14311.1 ESA23515.1 - 0.0029 17.3 0.1 0.0047 16.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4379) DUF2726 PF10881.3 ESA23515.1 - 0.12 11.9 0.1 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) Pkinase_Tyr PF07714.12 ESA23518.1 - 5.3e-22 78.1 0.1 8.4e-22 77.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23518.1 - 5.7e-20 71.5 0.1 9.6e-20 70.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA23518.1 - 5e-16 58.7 4.7 5e-08 33.3 0.1 2.9 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.1 ESA23518.1 - 5.9e-05 23.2 5.6 0.11 13.0 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA23518.1 - 0.0078 16.8 0.3 0.04 14.6 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Kinase-like PF14531.1 ESA23518.1 - 0.034 13.1 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like TPR_19 PF14559.1 ESA23518.1 - 0.043 14.1 1.2 6.2 7.2 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 ESA23518.1 - 0.085 12.5 5.3 0.33 10.6 3.7 2.1 1 1 0 1 1 1 0 TPR repeat TPR_2 PF07719.12 ESA23518.1 - 2.2 8.3 6.2 4.1 7.5 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat BTB PF00651.26 ESA23521.1 - 1.6e-10 40.9 0.0 2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Pox_A6 PF04924.7 ESA23521.1 - 0.038 12.7 0.2 0.048 12.4 0.1 1.1 1 0 0 1 1 1 0 Poxvirus A6 protein Pkinase PF00069.20 ESA23522.1 - 1.2e-25 90.1 0.0 1.5e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23522.1 - 9e-20 70.8 0.0 1.7e-19 69.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA23522.1 - 0.00053 19.3 0.0 0.00073 18.9 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 ESA23522.1 - 0.00095 18.9 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA23522.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase PF00069.20 ESA23523.1 - 0.055 12.6 0.1 0.096 11.8 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain Aldo_ket_red PF00248.16 ESA23524.1 - 4.9e-08 32.1 0.0 5.8e-08 31.8 0.0 1.2 1 1 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA23525.1 - 4e-30 104.6 0.0 4.5e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribonucleas_3_3 PF14622.1 ESA23527.1 - 1.3e-26 93.0 0.0 1.8e-25 89.3 0.0 2.0 2 0 0 2 2 2 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 ESA23527.1 - 5.8e-07 29.9 0.0 5.2e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease III domain Caps_synth_GfcC PF06251.6 ESA23529.1 - 0.13 11.4 0.9 0.14 11.2 0.6 1.0 1 0 0 1 1 1 0 Capsule biosynthesis GfcC Cytochrom_B561 PF03188.11 ESA23530.1 - 2.9e-16 59.5 3.2 2.9e-16 59.5 2.2 2.2 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 DUF1673 PF07895.6 ESA23530.1 - 0.087 12.3 3.5 0.15 11.6 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) DUF4199 PF13858.1 ESA23530.1 - 3.8 7.4 13.6 0.21 11.4 4.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) Complex1_51K PF01512.12 ESA23531.1 - 2e-48 163.9 0.0 2.9e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.4 ESA23531.1 - 5.2e-17 60.7 0.6 1.2e-16 59.5 0.4 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.4 ESA23531.1 - 8.3e-09 35.2 0.0 1.6e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 SLBB domain CAP_GLY PF01302.20 ESA23532.1 - 1.6e-21 75.7 0.1 3.2e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain BTB PF00651.26 ESA23532.1 - 1.8e-18 66.5 0.0 4.9e-12 45.8 0.0 2.5 1 1 1 2 2 2 2 BTB/POZ domain TetR_C PF02909.12 ESA23532.1 - 0.13 11.9 0.0 0.94 9.1 0.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor, C-terminal all-alpha domain Vps55 PF04133.9 ESA23533.1 - 3.1e-43 146.3 4.5 3.4e-43 146.1 3.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Aldo_ket_red PF00248.16 ESA23535.1 - 3.4e-29 101.5 0.0 3.7e-29 101.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F-box-like PF12937.2 ESA23536.1 - 1.3e-05 24.8 5.4 1.6e-05 24.4 0.4 2.7 2 1 1 3 3 3 1 F-box-like Sel1 PF08238.7 ESA23538.1 - 2.9e-241 774.6 133.3 5.5e-13 49.0 1.0 23.7 24 0 0 24 24 24 23 Sel1 repeat TPR_16 PF13432.1 ESA23538.1 - 4e-12 46.4 28.7 2.1 9.1 0.1 12.9 9 4 6 15 15 15 6 Tetratricopeptide repeat Flu_M1_C PF08289.6 ESA23538.1 - 3e-08 33.5 1.4 41 4.2 0.0 9.6 7 4 4 11 11 11 0 Influenza Matrix protein (M1) C-terminal domain TPR_6 PF13174.1 ESA23538.1 - 1.9e-06 27.9 73.0 2.3 8.8 0.0 19.2 21 0 0 21 21 21 4 Tetratricopeptide repeat TPR_11 PF13414.1 ESA23538.1 - 2.2e-05 24.0 122.9 0.0051 16.4 3.5 14.2 1 1 14 16 16 16 13 TPR repeat TPR_7 PF13176.1 ESA23538.1 - 1.9 8.4 31.3 2.4 8.1 0.1 9.9 11 1 1 12 12 12 0 Tetratricopeptide repeat DUF512 PF04459.7 ESA23538.1 - 5.1 6.1 8.1 15 4.5 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF512) CGI-121 PF08617.5 ESA23539.1 - 0.028 14.1 0.1 0.054 13.1 0.1 1.4 1 0 0 1 1 1 0 Kinase binding protein CGI-121 Methyltransf_10 PF05971.7 ESA23541.1 - 4.1e-83 278.9 0.0 1.2e-82 277.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF890) PrmA PF06325.8 ESA23541.1 - 1.1e-06 28.0 0.0 1.7e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 ESA23541.1 - 1.1e-06 28.1 0.0 3.8e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 ESA23541.1 - 1.4e-05 25.1 0.0 4.1e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 ESA23541.1 - 0.00081 19.0 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.11 ESA23541.1 - 0.0049 16.4 0.1 0.0078 15.8 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.1 ESA23541.1 - 0.0072 15.9 0.0 0.024 14.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23541.1 - 0.011 16.2 0.0 0.029 14.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain DUF633 PF04816.7 ESA23541.1 - 0.017 14.4 0.1 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF633) Cons_hypoth95 PF03602.10 ESA23541.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PseudoU_synth_1 PF01416.15 ESA23542.1 - 8e-20 71.2 0.2 1.4e-09 38.3 0.0 3.2 4 0 0 4 4 4 2 tRNA pseudouridine synthase RNA_pol_Rpb5_N PF03871.9 ESA23542.1 - 0.077 13.4 0.2 0.077 13.4 0.1 2.9 3 1 0 3 3 3 0 RNA polymerase Rpb5, N-terminal domain SLY PF12485.3 ESA23543.1 - 1.6 8.9 4.6 2.2 8.5 0.1 3.1 2 1 0 3 3 3 0 Lymphocyte signaling adaptor protein DUF4131 PF13567.1 ESA23545.1 - 0.021 14.2 1.1 0.03 13.7 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Shisa PF13908.1 ESA23545.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.1 ESA23545.1 - 0.42 10.3 18.1 2.5 7.7 7.4 3.0 2 1 0 2 2 2 0 TMEM154 protein family MitMem_reg PF13012.1 ESA23547.1 - 0.0045 17.0 2.9 0.8 9.8 0.2 2.7 2 1 0 2 2 2 2 Maintenance of mitochondrial structure and function DUF1435 PF07256.7 ESA23549.1 - 0.031 14.2 0.0 0.043 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1435) Pkinase_Tyr PF07714.12 ESA23552.1 - 0.036 13.1 0.0 0.12 11.4 0.0 1.7 1 1 1 2 2 2 0 Protein tyrosine kinase RAP PF08373.5 ESA23552.1 - 0.092 12.5 1.0 0.2 11.4 0.7 1.5 1 0 0 1 1 1 0 RAP domain WAP PF00095.16 ESA23553.1 - 0.02 14.8 1.8 0.02 14.8 1.2 2.3 2 0 0 2 2 2 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' PAN_4 PF14295.1 ESA23553.1 - 0.14 11.8 10.3 0.98 9.1 1.9 2.3 1 1 1 2 2 2 0 PAN domain Somatomedin_B PF01033.12 ESA23553.1 - 6 6.9 15.1 1.7 8.6 4.1 2.4 2 0 0 2 2 2 0 Somatomedin B domain p450 PF00067.17 ESA23554.1 - 8.6e-45 153.1 0.0 9.4e-45 152.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4238 PF14022.1 ESA23555.1 - 0.0087 15.3 4.2 0.01 15.1 2.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4238) PYC_OADA PF02436.13 ESA23555.1 - 0.12 11.7 0.2 0.21 10.9 0.1 1.5 1 0 0 1 1 1 0 Conserved carboxylase domain Pkinase_Tyr PF07714.12 ESA23557.1 - 0.00082 18.5 0.0 0.0018 17.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Sel1 PF08238.7 ESA23558.1 - 1.9e-137 444.6 40.7 5e-10 39.6 0.1 16.2 16 0 0 16 16 16 16 Sel1 repeat Pkinase_Tyr PF07714.12 ESA23558.1 - 4e-37 127.6 0.0 8.7e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23558.1 - 8.2e-32 110.3 0.3 8.2e-32 110.3 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain TPR_6 PF13174.1 ESA23558.1 - 0.013 15.8 27.3 16 6.1 0.0 10.4 14 0 0 14 14 14 0 Tetratricopeptide repeat Kdo PF06293.9 ESA23558.1 - 0.04 12.9 0.1 0.073 12.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23558.1 - 0.063 12.9 0.2 0.097 12.3 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2930 PF11152.3 ESA23558.1 - 0.19 10.8 0.0 1.7e+02 1.2 0.0 4.7 5 1 2 7 7 7 0 Protein of unknown function (DUF2930) HATPase_c PF02518.21 ESA23559.1 - 3.1e-52 174.9 0.6 8.9e-25 86.5 0.0 2.8 3 0 0 3 3 3 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 ESA23559.1 - 6.1e-26 90.6 0.1 1.3e-24 86.3 0.0 3.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.20 ESA23559.1 - 6.7e-25 86.8 6.1 4.2e-15 55.4 0.2 3.1 2 1 0 2 2 2 2 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.1 ESA23559.1 - 6.7e-15 55.3 0.0 2.7e-10 40.4 0.0 2.9 2 0 0 2 2 2 2 GAF domain GAF PF01590.21 ESA23559.1 - 5.8e-08 33.0 0.0 1.8e-07 31.3 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.1 ESA23559.1 - 7.9e-07 29.6 0.0 3.8e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 GAF domain PAS_4 PF08448.5 ESA23559.1 - 0.0023 17.9 0.0 0.0056 16.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold HATPase_c_2 PF13581.1 ESA23559.1 - 0.0063 16.3 0.0 0.31 10.8 0.0 2.7 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain CbiZ PF01955.13 ESA23559.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Adenosylcobinamide amidohydrolase Pkinase_Tyr PF07714.12 ESA23560.1 - 1.7e-35 122.3 0.0 5.1e-35 120.8 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23560.1 - 2.1e-35 122.1 1.5 3.7e-34 118.0 0.3 2.5 2 1 0 2 2 2 1 Protein kinase domain Biopterin_H PF00351.16 ESA23560.1 - 0.0064 15.2 0.1 0.012 14.3 0.0 1.4 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase DUF2789 PF10982.3 ESA23560.1 - 0.082 12.9 1.9 8 6.5 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2789) F-box-like PF12937.2 ESA23561.1 - 5.2e-07 29.2 2.1 1.7e-06 27.6 1.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 ESA23561.1 - 0.0049 16.4 0.5 0.024 14.3 0.3 2.2 1 0 0 1 1 1 1 F-box domain CRF-BP PF05428.6 ESA23561.1 - 0.034 13.0 0.0 0.055 12.3 0.0 1.2 1 0 0 1 1 1 0 Corticotropin-releasing factor binding protein (CRF-BP) zf-H2C2_2 PF13465.1 ESA23563.1 - 6.3e-07 29.3 13.2 8.8e-07 28.9 1.0 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 ESA23563.1 - 0.00028 20.9 19.2 0.0018 18.5 0.4 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 ESA23563.1 - 0.00082 19.5 18.6 0.0055 16.9 0.6 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-Di19 PF05605.7 ESA23563.1 - 0.0018 18.3 8.3 0.024 14.7 1.3 2.8 2 1 1 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Prim_Zn_Ribbon PF08273.7 ESA23563.1 - 0.18 11.9 0.3 0.18 11.9 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Transpos_assoc PF13963.1 ESA23563.1 - 3.3 7.7 6.4 10 6.2 2.1 2.6 1 1 1 2 2 2 0 Transposase-associated domain Pkinase_Tyr PF07714.12 ESA23565.1 - 6.4e-11 41.8 0.0 0.0023 17.0 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA23565.1 - 4.7e-08 32.4 0.2 0.00011 21.4 0.0 3.1 1 1 1 3 3 3 2 Protein kinase domain GHL12 PF14882.1 ESA23565.1 - 0.12 12.5 1.9 0.13 12.3 0.1 2.0 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 12 BCS1_N PF08740.6 ESA23565.1 - 0.13 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 BCS1 N terminal BTB PF00651.26 ESA23568.1 - 6.2e-19 68.0 0.7 8.5e-19 67.5 0.5 1.2 1 0 0 1 1 1 1 BTB/POZ domain Fungal_trans PF04082.13 ESA23568.1 - 0.054 12.3 0.8 0.14 10.9 0.2 1.8 1 1 1 2 2 2 0 Fungal specific transcription factor domain UQ_con PF00179.21 ESA23569.1 - 6.3e-40 135.8 0.0 8e-40 135.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA23569.1 - 0.068 12.9 0.0 0.074 12.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.8 ESA23569.1 - 0.091 12.4 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 UEV domain adh_short_C2 PF13561.1 ESA23570.1 - 2.9e-36 125.4 0.3 3.5e-36 125.1 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 ESA23570.1 - 7.6e-26 91.0 0.1 9.8e-26 90.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA23570.1 - 1.2e-11 44.5 0.0 1.6e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.12 ESA23570.1 - 0.0015 18.9 0.8 0.0035 17.7 0.5 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.10 ESA23570.1 - 0.0026 16.7 0.0 0.0049 15.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.5 ESA23570.1 - 0.0059 15.7 0.0 0.0089 15.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 ESA23570.1 - 0.0061 15.5 0.8 0.025 13.5 0.6 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 ESA23570.1 - 0.013 15.5 0.2 0.022 14.8 0.2 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ATP_bind_1 PF03029.12 ESA23571.1 - 3e-86 288.8 0.1 3.4e-86 288.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CbiA PF01656.18 ESA23571.1 - 0.0004 19.8 0.0 0.00069 19.0 0.0 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.1 ESA23571.1 - 0.055 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESA23571.1 - 0.076 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 ESA23571.1 - 0.087 11.5 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_19 PF13245.1 ESA23571.1 - 0.098 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain MobB PF03205.9 ESA23571.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 ESA23571.1 - 0.12 13.1 0.9 0.31 11.8 0.6 1.9 1 1 0 1 1 1 0 AAA domain Methyltransf_16 PF10294.4 ESA23572.1 - 8.6e-05 22.0 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase EFP_N PF08207.7 ESA23572.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain zinc_ribbon_6 PF14599.1 ESA23572.1 - 0.19 11.5 1.5 0.57 10.0 0.9 1.9 2 0 0 2 2 2 0 Zinc-ribbon Methyltransf_16 PF10294.4 ESA23573.1 - 1.4e-05 24.6 0.0 2.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase DUF1738 PF08401.6 ESA23573.1 - 0.082 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) Helicase_C_3 PF13625.1 ESA23574.1 - 5.4e-26 90.8 0.1 2.7e-25 88.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 ESA23574.1 - 1.2e-15 57.7 1.5 1.2e-14 54.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 ESA23574.1 - 1.1e-11 44.0 0.1 1.9e-11 43.3 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 ESA23574.1 - 7.6e-08 32.0 0.1 1.3e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA23574.1 - 2.8e-05 23.8 0.0 6.2e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LRR_adjacent PF08191.6 ESA23575.1 - 0.012 15.3 0.5 0.013 15.1 0.3 1.2 1 0 0 1 1 1 0 LRR adjacent S100PBPR PF15427.1 ESA23575.1 - 0.022 13.8 0.1 0.022 13.8 0.1 1.0 1 0 0 1 1 1 0 S100P-binding protein WD40 PF00400.27 ESA23576.1 - 9.2e-21 72.9 3.2 0.0036 17.1 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Lactonase PF10282.4 ESA23576.1 - 0.00025 20.2 0.0 0.0015 17.6 0.0 2.1 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SGL PF08450.7 ESA23576.1 - 0.019 14.3 0.1 0.29 10.4 0.0 2.6 2 1 0 2 2 2 0 SMP-30/Gluconolaconase/LRE-like region Whi5 PF08528.6 ESA23577.1 - 2.8e-05 23.5 1.0 5.4e-05 22.6 0.7 1.5 1 0 0 1 1 1 1 Whi5 like HMG_box PF00505.14 ESA23578.1 - 0.0015 18.7 0.1 0.0027 17.9 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box ECM11 PF15463.1 ESA23578.1 - 0.17 12.1 1.9 0.17 12.1 0.9 1.4 1 1 0 1 1 1 0 Extracellular mutant protein 11 Sigma54_activ_2 PF14532.1 ESA23580.1 - 0.13 12.3 0.1 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Pkinase_Tyr PF07714.12 ESA23582.1 - 1.2e-54 185.0 0.0 1.8e-54 184.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23582.1 - 1.7e-48 165.0 0.2 2.3e-48 164.6 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23582.1 - 0.0017 17.4 0.3 0.0049 15.9 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA23582.1 - 0.0048 15.9 0.0 0.0072 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA23582.1 - 0.036 13.8 0.1 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Imm22 PF15592.1 ESA23583.1 - 0.00043 20.5 2.5 0.00065 20.0 1.3 1.7 1 1 0 1 1 1 1 Immunity protein 22 UPF0228 PF05727.6 ESA23583.1 - 0.12 12.0 5.2 0.06 13.1 2.3 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0228) DUF106 PF01956.11 ESA23583.1 - 0.44 10.0 4.5 0.51 9.8 2.9 1.3 1 1 0 1 1 1 0 Integral membrane protein DUF106 LOH1CR12 PF10158.4 ESA23583.1 - 0.48 10.2 5.2 0.86 9.4 2.8 1.8 1 1 1 2 2 2 0 Tumour suppressor protein Gluconate_2-dh3 PF13618.1 ESA23583.1 - 0.61 10.2 2.4 0.91 9.6 1.7 1.4 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 PAPS_reduct PF01507.14 ESA23583.1 - 1.1 9.0 6.5 2.1 8.1 4.5 1.5 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Ribosomal_S2 PF00318.15 ESA23583.1 - 1.1 8.4 9.9 1.9 7.6 6.9 1.7 1 1 0 1 1 1 0 Ribosomal protein S2 DUF4375 PF14300.1 ESA23583.1 - 1.2 9.1 7.9 21 5.1 5.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) AAA_23 PF13476.1 ESA23583.1 - 4.8 7.4 21.4 5.5 7.2 14.8 1.1 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.5 ESA23583.1 - 5.4 7.1 8.7 2.9 8.0 3.5 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family zf-RVT PF13966.1 ESA23584.1 - 0.0083 16.4 2.7 0.0095 16.2 0.4 2.1 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase WWE PF02825.15 ESA23585.1 - 0.049 13.0 0.8 0.084 12.3 0.1 1.8 2 1 0 2 2 2 0 WWE domain Apolipoprotein PF01442.13 ESA23586.1 - 2.8e-05 23.7 7.8 4e-05 23.2 5.4 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SF-assemblin PF06705.6 ESA23586.1 - 0.0066 15.6 10.2 0.0099 15.0 7.0 1.2 1 0 0 1 1 1 1 SF-assemblin/beta giardin OmpH PF03938.9 ESA23586.1 - 0.022 14.6 11.4 0.044 13.7 7.9 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HSBP1 PF06825.7 ESA23586.1 - 0.14 11.7 20.4 0.021 14.4 10.2 2.4 1 1 1 2 2 2 0 Heat shock factor binding protein 1 Prenyltransf PF01255.14 ESA23586.1 - 0.24 10.5 11.0 0.19 10.8 4.5 2.4 2 1 0 2 2 2 0 Putative undecaprenyl diphosphate synthase WXG100 PF06013.7 ESA23586.1 - 0.24 11.4 7.5 0.43 10.5 5.2 1.5 1 0 0 1 1 1 0 Proteins of 100 residues with WXG DUF2203 PF09969.4 ESA23586.1 - 2.4 8.3 6.5 4.2 7.6 4.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Phage_Gp23 PF10669.4 ESA23586.1 - 3.7 7.6 14.0 0.18 11.9 4.3 2.8 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) UXS1_N PF11803.3 ESA23586.1 - 3.7 7.3 10.5 1.4 8.7 0.6 2.5 1 1 1 2 2 2 0 UDP-glucuronate decarboxylase N-terminal HMG_box PF00505.14 ESA23587.1 - 2.8e-06 27.5 0.4 5.9e-06 26.4 0.3 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23587.1 - 3.1e-06 27.4 0.2 7.4e-06 26.2 0.2 1.6 1 0 0 1 1 1 1 HMG-box domain Dimer_Tnp_hAT PF05699.9 ESA23588.1 - 3.5e-19 68.1 0.0 6.4e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4413 PF14372.1 ESA23588.1 - 0.018 15.0 0.3 0.031 14.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) DUF3584 PF12128.3 ESA23592.1 - 0.00043 17.7 45.9 0.00043 17.7 31.8 2.5 1 1 2 3 3 3 2 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 ESA23592.1 - 0.0045 16.2 39.3 0.04 13.1 6.2 4.5 1 1 2 4 4 4 2 Reovirus sigma C capsid protein Fez1 PF06818.10 ESA23592.1 - 0.0083 16.1 11.3 0.0083 16.1 7.8 5.1 1 1 3 4 4 4 1 Fez1 IncA PF04156.9 ESA23592.1 - 1.9 8.0 83.3 0.05 13.1 12.3 5.0 2 1 3 5 5 5 0 IncA protein DUF2580 PF10824.3 ESA23592.1 - 9.7 6.6 11.6 9.5 6.6 3.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2580) Methyltransf_11 PF08241.7 ESA23593.1 - 1.6e-11 44.5 0.0 2.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA23593.1 - 2.2e-10 40.4 0.0 3.3e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 ESA23593.1 - 6.7e-09 35.1 0.0 1.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 ESA23593.1 - 4.1e-06 26.4 0.0 9.5e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA23593.1 - 6.4e-06 26.4 0.0 1.4e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA23593.1 - 5.3e-05 23.2 0.0 9.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 ESA23593.1 - 7.3e-05 21.2 0.0 0.0001 20.8 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.7 ESA23593.1 - 0.0003 21.2 0.0 0.001 19.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23593.1 - 0.0083 16.7 0.0 0.021 15.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA23593.1 - 0.027 13.5 0.0 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_9 PF08003.6 ESA23593.1 - 0.067 11.8 0.0 0.14 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GIY-YIG PF01541.19 ESA23594.1 - 2e-10 40.8 0.2 5.3e-10 39.5 0.0 1.8 2 0 0 2 2 2 1 GIY-YIG catalytic domain zf-RING-like PF08746.6 ESA23594.1 - 0.011 15.7 2.0 0.032 14.2 0.1 2.1 2 0 0 2 2 2 0 RING-like domain T5orf172 PF10544.4 ESA23594.1 - 0.015 15.7 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 T5orf172 domain FANCL_C PF11793.3 ESA23594.1 - 0.023 14.6 6.4 0.35 10.8 4.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.1 ESA23594.1 - 0.027 14.4 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 ESA23594.1 - 0.031 14.4 0.1 0.05 13.7 0.1 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.1 ESA23594.1 - 0.056 13.2 0.6 0.12 12.2 0.4 1.6 1 0 0 1 1 1 0 Ring finger domain Pkinase_Tyr PF07714.12 ESA23596.1 - 2.3e-39 135.0 0.0 3e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23596.1 - 2.6e-34 118.5 0.0 3.4e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.9 ESA23596.1 - 0.0064 15.5 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.2 ESA23598.1 - 0.00051 19.7 4.8 0.0013 18.4 2.4 2.4 3 0 0 3 3 3 1 F-box-like SRX PF09201.5 ESA23598.1 - 0.0087 15.7 1.3 0.024 14.2 0.9 1.7 1 0 0 1 1 1 1 SRX ParB PF08775.5 ESA23598.1 - 0.058 13.7 0.5 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 ParB family F-box PF00646.28 ESA23598.1 - 0.39 10.4 5.5 0.2 11.3 0.8 2.7 3 0 0 3 3 3 0 F-box domain DUF2150 PF09920.4 ESA23599.1 - 0.0055 16.3 0.2 0.0071 15.9 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2150) IFT20 PF14931.1 ESA23599.1 - 0.015 15.1 1.2 1.2 9.0 0.1 2.3 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 APG17 PF04108.7 ESA23599.1 - 0.023 13.5 4.4 0.17 10.6 3.1 1.9 1 1 0 1 1 1 0 Autophagy protein Apg17 KCNQ_channel PF03520.9 ESA23599.1 - 0.024 13.9 0.1 0.13 11.6 0.0 2.0 2 0 0 2 2 2 0 KCNQ voltage-gated potassium channel Jnk-SapK_ap_N PF09744.4 ESA23599.1 - 0.024 14.6 3.2 0.42 10.5 0.1 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 HeLo PF14479.1 ESA23599.1 - 0.037 13.7 2.7 1 9.0 0.1 2.2 1 1 1 2 2 2 0 Prion-inhibition and propagation Laminin_II PF06009.7 ESA23599.1 - 0.047 13.4 0.7 0.27 11.0 0.1 2.0 1 1 1 2 2 2 0 Laminin Domain II EntA_Immun PF08951.5 ESA23599.1 - 0.061 13.4 2.3 0.084 13.0 0.1 2.2 2 1 1 3 3 3 0 Enterocin A Immunity DUF4635 PF15466.1 ESA23599.1 - 0.092 12.0 0.1 0.56 9.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) Elf1 PF05129.8 ESA23599.1 - 0.1 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF4164 PF13747.1 ESA23599.1 - 0.11 12.6 0.2 0.11 12.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) TroA PF01297.12 ESA23599.1 - 0.14 11.3 1.4 0.75 8.9 0.1 2.0 1 1 1 2 2 2 0 Periplasmic solute binding protein family DUF1451 PF07295.6 ESA23599.1 - 0.19 11.5 1.0 0.65 9.7 0.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1451) DUF972 PF06156.8 ESA23599.1 - 0.46 10.8 2.3 0.67 10.3 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF2458 PF10454.4 ESA23599.1 - 0.59 10.0 4.1 0.53 10.1 0.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2458) DUF349 PF03993.7 ESA23599.1 - 0.69 10.1 5.6 1.8 8.8 0.5 2.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) IncA PF04156.9 ESA23599.1 - 0.74 9.3 5.3 11 5.5 3.7 2.0 1 1 0 1 1 1 0 IncA protein GTSE1_N PF15259.1 ESA23600.1 - 0.0055 16.6 1.7 0.95 9.4 0.0 3.3 3 1 0 3 3 3 1 G-2 and S-phase expressed 1 Pex14_N PF04695.8 ESA23600.1 - 0.11 12.5 6.7 0.48 10.4 0.3 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region bZIP_C PF12498.3 ESA23600.1 - 0.39 11.9 6.6 0.3 12.3 0.7 2.3 2 0 0 2 2 2 0 Basic leucine-zipper C terminal Sel1 PF08238.7 ESA23601.1 - 6.6e-111 360.3 49.3 5.7e-11 42.6 0.0 15.3 15 0 0 15 15 15 15 Sel1 repeat Pkinase_Tyr PF07714.12 ESA23601.1 - 9.4e-35 119.9 0.1 1.6e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23601.1 - 8.8e-34 116.8 0.5 1.5e-33 116.0 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.17 ESA23601.1 - 0.00023 20.5 0.2 0.00023 20.5 0.1 2.3 2 0 0 2 2 2 1 RIO1 family Kinase-like PF14531.1 ESA23601.1 - 0.003 16.5 0.0 0.0061 15.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Flu_M1_C PF08289.6 ESA23601.1 - 0.0037 17.2 0.7 8.9 6.4 0.0 4.3 3 1 1 4 4 4 1 Influenza Matrix protein (M1) C-terminal domain Kdo PF06293.9 ESA23601.1 - 0.0039 16.2 0.0 0.0082 15.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA23601.1 - 0.024 14.3 0.1 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_16 PF13432.1 ESA23601.1 - 0.027 15.1 1.9 4.7 8.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 ESA23601.1 - 1.5 9.4 20.2 14 6.3 0.1 8.5 9 1 0 9 9 9 0 Tetratricopeptide repeat RNF111_N PF15303.1 ESA23602.1 - 0.11 12.0 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus DUF4535 PF15054.1 ESA23603.1 - 0.15 11.4 0.2 0.61 9.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) BTB PF00651.26 ESA23605.1 - 2.4e-18 66.1 0.1 5.5e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA23605.1 - 4.5e-13 49.3 2.5 1.1e-12 48.1 1.7 1.7 1 1 0 1 1 1 1 TLD BACK PF07707.10 ESA23605.1 - 6.1e-06 26.0 5.1 0.0024 17.6 0.8 4.0 2 1 2 4 4 4 2 BTB And C-terminal Kelch DUF285 PF03382.9 ESA23605.1 - 0.019 14.5 0.1 0.042 13.4 0.1 1.5 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 BTB PF00651.26 ESA23606.1 - 2.1e-16 59.8 0.8 4.5e-16 58.8 0.2 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23606.1 - 1.1e-14 54.5 1.0 2e-14 53.7 0.7 1.4 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA23606.1 - 0.00021 21.0 3.3 0.0046 16.7 1.6 2.9 1 1 0 1 1 1 1 BTB And C-terminal Kelch Sedlin_N PF04628.8 ESA23607.1 - 8.4e-33 113.0 0.2 9.7e-33 112.8 0.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 ESA23607.1 - 0.0034 17.1 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family TLD PF07534.11 ESA23608.1 - 2.9e-16 59.6 3.0 7.6e-16 58.3 2.1 1.8 1 0 0 1 1 1 1 TLD BTB PF00651.26 ESA23608.1 - 1.1e-15 57.5 0.0 2.5e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA23608.1 - 0.00052 19.8 5.8 0.0073 16.1 1.8 3.7 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF3567 PF12091.3 ESA23614.1 - 0.031 14.2 0.1 0.054 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) DUF1542 PF07564.6 ESA23615.1 - 0.063 13.2 1.3 0.063 13.2 0.9 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Pkinase PF00069.20 ESA23616.1 - 1.5e-09 37.4 0.1 2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23616.1 - 2.1e-07 30.3 0.0 2.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23617.1 - 3.2e-05 23.2 0.5 5.4e-05 22.4 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain AAA_15 PF13175.1 ESA23617.1 - 0.039 12.9 2.2 0.051 12.6 1.5 1.2 1 0 0 1 1 1 0 AAA ATPase domain EntA_Immun PF08951.5 ESA23617.1 - 0.08 13.1 0.5 0.18 11.9 0.1 1.7 2 0 0 2 2 2 0 Enterocin A Immunity Bac_DnaA_C PF08299.6 ESA23618.1 - 0.05 13.4 0.1 0.055 13.3 0.1 1.1 1 0 0 1 1 1 0 Bacterial dnaA protein helix-turn-helix RTC4 PF14474.1 ESA23619.1 - 8.8e-14 51.5 0.0 1.1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 RTC4-like domain RVP PF00077.15 ESA23620.1 - 0.0028 17.5 0.0 0.013 15.3 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 ESA23620.1 - 0.0033 17.2 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 ESA23620.1 - 0.0081 16.6 0.0 0.013 15.9 0.0 1.4 1 1 0 1 1 1 1 Aspartyl protease Mannosyl_trans2 PF04188.8 ESA23620.1 - 0.03 13.2 0.1 0.037 12.9 0.1 1.1 1 0 0 1 1 1 0 Mannosyltransferase (PIG-V)) SET PF00856.23 ESA23621.1 - 0.00019 21.7 0.5 0.00032 21.0 0.4 1.4 1 0 0 1 1 1 1 SET domain BTB PF00651.26 ESA23624.1 - 1.3e-14 54.1 0.6 3.2e-14 52.8 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23624.1 - 1.2e-10 41.4 1.8 8e-10 38.8 0.0 2.8 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA23624.1 - 8.4e-06 25.5 3.5 0.00036 20.3 0.5 4.0 3 1 2 5 5 5 1 BTB And C-terminal Kelch Seadorna_VP6 PF07407.6 ESA23626.1 - 0.16 10.7 0.3 0.19 10.4 0.2 1.0 1 0 0 1 1 1 0 Seadornavirus VP6 protein rve PF00665.21 ESA23627.1 - 0.025 14.6 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Pox_A32 PF04665.7 ESA23629.1 - 6e-12 45.3 0.1 3.5e-07 29.7 0.0 2.2 2 0 0 2 2 2 2 Poxvirus A32 protein AAA_10 PF12846.2 ESA23629.1 - 5.6e-05 22.7 0.0 0.06 12.7 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain Zot PF05707.7 ESA23629.1 - 0.0067 15.9 0.0 0.27 10.6 0.0 2.2 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_22 PF13401.1 ESA23629.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 ESA23629.1 - 0.012 16.4 0.0 0.037 14.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 ESA23629.1 - 0.018 14.7 0.1 0.031 13.9 0.1 1.3 1 0 0 1 1 1 0 NACHT domain FtsK_SpoIIIE PF01580.13 ESA23629.1 - 0.019 14.4 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.1 ESA23629.1 - 0.031 13.7 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 ESA23629.1 - 0.033 14.5 0.0 0.05 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.14 ESA23629.1 - 0.047 12.9 0.0 0.079 12.1 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_19 PF13245.1 ESA23629.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain Miro PF08477.8 ESA23629.1 - 0.063 13.7 0.2 0.77 10.2 0.0 2.2 2 0 0 2 2 2 0 Miro-like protein AAA_16 PF13191.1 ESA23629.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.14 ESA23629.1 - 0.13 11.6 0.1 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RB_A PF01858.12 ESA23630.1 - 0.13 11.8 1.5 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Retinoblastoma-associated protein A domain BTB PF00651.26 ESA23631.1 - 2.8e-14 53.0 1.8 4.7e-14 52.3 1.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain Abhydrolase_6 PF12697.2 ESA23636.1 - 2.6e-29 102.7 0.0 3.5e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA23636.1 - 6.4e-18 64.9 0.0 4.6e-17 62.1 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA23636.1 - 6.1e-11 42.3 0.0 5.5e-08 32.6 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Lipase_2 PF01674.13 ESA23636.1 - 2.5e-05 23.6 0.0 4.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 2) PGAP1 PF07819.8 ESA23636.1 - 9.1e-05 22.1 0.0 0.00024 20.7 0.0 1.6 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.3 ESA23636.1 - 0.00019 21.2 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Ser_hydrolase PF06821.8 ESA23636.1 - 0.00059 19.4 0.0 0.032 13.8 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase Chlorophyllase PF07224.6 ESA23636.1 - 0.00078 18.3 0.0 0.0014 17.4 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase AXE1 PF05448.7 ESA23636.1 - 0.0036 15.8 0.0 0.0077 14.7 0.0 1.4 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) DUF2305 PF10230.4 ESA23636.1 - 0.0045 16.4 0.0 0.0061 16.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_3 PF07859.8 ESA23636.1 - 0.0048 16.4 0.0 0.014 14.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 ESA23636.1 - 0.0065 15.7 0.0 0.83 8.8 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Chlorophyllase2 PF12740.2 ESA23636.1 - 0.0066 15.3 0.0 0.013 14.3 0.0 1.5 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.16 ESA23636.1 - 0.014 14.6 0.0 0.34 10.0 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family LCAT PF02450.10 ESA23636.1 - 0.021 13.8 0.0 0.044 12.7 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF1749 PF08538.5 ESA23636.1 - 0.035 13.0 0.0 0.098 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Lipase_3 PF01764.20 ESA23636.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Pkinase_Tyr PF07714.12 ESA23637.1 - 6.4e-47 159.8 0.0 9.6e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23637.1 - 2.6e-44 151.3 0.0 4.2e-44 150.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FlgI PF02119.11 ESA23637.1 - 0.042 12.4 0.6 0.06 11.9 0.4 1.2 1 0 0 1 1 1 0 Flagellar P-ring protein NAD_binding_6 PF08030.7 ESA23637.1 - 0.12 12.3 1.9 0.24 11.2 1.3 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF2659 PF10858.3 ESA23638.1 - 0.054 12.8 0.1 0.071 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) DUF3028 PF11229.3 ESA23638.1 - 0.07 11.4 0.0 0.078 11.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3028) BTB PF00651.26 ESA23639.1 - 2e-12 47.0 0.6 3.2e-12 46.4 0.4 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4142 PF13628.1 ESA23640.1 - 0.015 15.2 0.1 0.028 14.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) MIR PF02815.14 ESA23640.1 - 0.045 13.2 3.1 0.072 12.6 1.5 1.5 1 1 1 2 2 2 0 MIR domain DUF4414 PF14377.1 ESA23642.1 - 0.078 12.8 0.7 0.25 11.2 0.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4414) zf-Apc11 PF12861.2 ESA23647.1 - 0.015 15.0 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESA23647.1 - 0.13 12.3 0.3 0.22 11.6 0.2 1.3 1 0 0 1 1 1 0 RING-H2 zinc finger DYW_deaminase PF14432.1 ESA23648.1 - 2.9e-06 27.2 0.3 5.2e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases OTT_1508_deam PF14441.1 ESA23648.1 - 6.6e-06 25.9 0.1 1.2e-05 25.1 0.1 1.4 1 1 0 1 1 1 1 OTT_1508-like deaminase OTT_1508_deam PF14441.1 ESA23649.1 - 2e-07 30.9 0.1 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 OTT_1508-like deaminase TLD PF07534.11 ESA23651.1 - 2.1e-17 63.4 1.8 7.3e-17 61.6 0.2 2.5 3 0 0 3 3 3 1 TLD BTB PF00651.26 ESA23651.1 - 7e-17 61.4 0.3 1.5e-16 60.3 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA23651.1 - 0.0004 20.1 1.9 0.0018 18.0 0.3 2.7 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 ESA23652.1 - 0.004 17.1 0.2 0.01 15.8 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain NAAA-beta PF15508.1 ESA23652.1 - 0.054 13.8 0.2 4.6 7.6 0.1 3.1 2 1 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase zf-DHHC PF01529.15 ESA23653.1 - 1.1 8.6 5.8 0.3 10.4 1.6 1.8 2 0 0 2 2 2 0 DHHC palmitoyltransferase HlyIII PF03006.15 ESA23655.1 - 1.8e-61 207.3 28.7 2.3e-61 207.0 19.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related MULE PF10551.4 ESA23656.1 - 0.0097 16.0 0.2 0.02 15.0 0.1 1.7 1 1 0 1 1 1 1 MULE transposase domain RNase_H PF00075.19 ESA23657.1 - 1.3e-05 25.5 0.2 0.0001 22.6 0.0 2.0 2 0 0 2 2 2 1 RNase H HSP70 PF00012.15 ESA23659.1 - 1.6e-36 125.4 0.3 1.7e-36 125.3 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein Big_5 PF13205.1 ESA23660.1 - 0.0003 21.3 2.3 0.0059 17.1 0.6 2.7 2 0 0 2 2 2 1 Bacterial Ig-like domain DUF4420 PF14390.1 ESA23660.1 - 0.07 11.9 0.1 0.16 10.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4420) Pkinase PF00069.20 ESA23661.1 - 8.7e-26 90.6 0.3 1.1e-20 73.8 0.3 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23661.1 - 4e-25 88.3 0.0 4.2e-22 78.4 0.0 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 ESA23661.1 - 2.5e-05 23.7 1.3 3.7e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA23661.1 - 0.0024 17.6 0.4 0.0092 15.7 0.3 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA23661.1 - 0.069 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glutaredoxin PF00462.19 ESA23666.1 - 0.0016 18.3 0.1 3.4 7.7 0.0 3.4 3 0 0 3 3 3 2 Glutaredoxin TraT PF05818.7 ESA23666.1 - 0.028 13.8 0.4 3.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein EAF PF09816.4 ESA23666.1 - 0.045 13.7 0.2 4.3 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription elongation factor DUF2789 PF10982.3 ESA23666.1 - 0.048 13.6 0.7 1.6 8.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) Mvb12 PF09452.5 ESA23666.1 - 1.7 8.9 5.7 4.5 7.5 0.2 3.4 2 2 1 3 3 3 0 ESCRT-I subunit Mvb12 Aldo_ket_red PF00248.16 ESA23667.1 - 0.00013 20.9 0.0 0.00015 20.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family KH_5 PF13184.1 ESA23667.1 - 0.15 11.8 0.6 1.3 8.9 0.3 1.9 1 1 1 2 2 2 0 NusA-like KH domain UCH PF00443.24 ESA23668.1 - 6e-56 189.5 7.5 6e-56 189.5 5.2 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 ESA23668.1 - 3.7e-22 79.1 7.0 8.1e-22 78.0 4.8 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 ESA23668.1 - 1.2e-17 63.7 8.0 1.2e-17 63.7 5.5 3.1 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein ORC2 PF04084.9 ESA23669.1 - 3.6e-38 131.2 9.4 5.4e-38 130.6 6.5 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 TIG PF01833.19 ESA23670.1 - 2.9e-13 49.6 1.0 2.9e-13 49.6 0.7 2.7 2 0 0 2 2 2 1 IPT/TIG domain Ank PF00023.25 ESA23670.1 - 5e-13 48.1 0.1 1.7e-05 24.3 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 ESA23670.1 - 7.5e-13 48.2 0.5 8.9e-08 32.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 ESA23670.1 - 2.4e-12 47.0 0.0 8.1e-12 45.3 0.0 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 ESA23670.1 - 1.1e-11 44.9 0.1 2.6e-11 43.7 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 ESA23670.1 - 6.9e-08 32.0 0.1 0.0087 16.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat PilZ PF07238.9 ESA23670.1 - 0.03 14.3 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 PilZ domain TRAPP PF04051.11 ESA23671.1 - 1.6e-39 134.8 0.0 2e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Terminase_4 PF05119.7 ESA23671.1 - 0.023 14.8 0.1 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Phage terminase, small subunit AAA_32 PF13654.1 ESA23671.1 - 0.047 12.3 0.0 0.058 12.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain MOZ_SAS PF01853.13 ESA23672.1 - 8e-77 256.7 1.9 1.1e-76 256.2 1.4 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 ESA23672.1 - 2.8e-11 42.9 0.9 5.1e-11 42.1 0.6 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Topoisom_I_N PF02919.10 ESA23673.1 - 0.045 13.0 2.4 0.082 12.1 1.6 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Pkinase_Tyr PF07714.12 ESA23674.1 - 2.1e-49 167.9 0.0 1.1e-41 142.6 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 ESA23674.1 - 5.4e-47 160.1 1.1 9.1e-36 123.3 0.0 3.3 3 0 0 3 3 3 2 Protein kinase domain RIO1 PF01163.17 ESA23674.1 - 0.00023 20.5 1.8 0.00036 19.9 0.1 2.2 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 ESA23674.1 - 0.0087 15.8 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA23674.1 - 0.0087 15.1 0.2 0.044 12.8 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 ESA23675.1 - 1.3e-46 158.8 0.0 1.7e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23675.1 - 1.1e-45 155.8 0.0 2.3e-45 154.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 ESA23675.1 - 0.0069 16.1 0.5 0.018 14.7 0.2 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family WaaY PF06176.6 ESA23675.1 - 0.0088 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA23675.1 - 0.055 12.5 0.1 0.11 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA23675.1 - 0.09 12.1 0.3 0.16 11.3 0.2 1.3 1 0 0 1 1 1 0 RIO1 family DUF2533 PF10752.4 ESA23676.1 - 0.085 13.1 0.6 0.15 12.3 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2533) SopA PF13981.1 ESA23678.1 - 0.0085 16.1 0.2 0.025 14.5 0.1 1.8 1 0 0 1 1 1 1 SopA-like central domain DcpS_C PF11969.3 ESA23679.1 - 4.4e-24 84.9 0.4 7.3e-24 84.2 0.3 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 ESA23679.1 - 3.9e-10 40.1 4.3 1.5e-09 38.2 3.0 1.8 1 1 0 1 1 1 1 HIT domain CwfJ_C_1 PF04677.10 ESA23679.1 - 0.00011 21.8 1.8 0.00018 21.1 1.2 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 PTRF_SDPR PF15237.1 ESA23679.1 - 0.11 11.8 1.6 0.15 11.4 1.1 1.1 1 0 0 1 1 1 0 PTRF/SDPR family TRAP_alpha PF03896.11 ESA23679.1 - 0.21 10.5 4.8 0.26 10.2 3.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tom22 PF04281.8 ESA23679.1 - 0.27 10.7 3.4 0.43 10.1 2.3 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Apc15p PF05841.6 ESA23679.1 - 0.42 11.3 9.5 0.68 10.6 6.6 1.2 1 0 0 1 1 1 0 Apc15p protein HMG_box PF00505.14 ESA23680.1 - 1.2e-18 67.1 1.0 1.2e-18 67.1 0.7 2.9 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23680.1 - 1.3e-15 57.5 1.6 1.3e-15 57.5 1.1 3.9 4 2 0 4 4 4 1 HMG-box domain HMG_box PF00505.14 ESA23681.1 - 3.4e-44 148.9 2.5 8e-22 77.2 0.1 2.1 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23681.1 - 1.2e-33 115.3 0.5 7.2e-16 58.3 0.1 2.1 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.7 ESA23681.1 - 1.8e-05 24.3 0.1 0.1 12.3 0.0 2.5 2 0 0 2 2 2 2 CHDNT (NUC034) domain Imm35 PF15581.1 ESA23681.1 - 0.00013 21.9 0.1 0.062 13.3 0.0 2.1 2 0 0 2 2 2 2 Immunity protein 35 HMG_box_5 PF14887.1 ESA23681.1 - 0.00048 19.8 2.6 0.00099 18.8 0.2 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box 5 RIB43A PF05914.7 ESA23681.1 - 0.0012 17.5 1.0 0.18 10.3 0.0 2.1 2 0 0 2 2 2 2 RIB43A Tol_Tol_Ttg2 PF05494.7 ESA23681.1 - 0.0095 15.5 0.0 0.67 9.4 0.0 2.2 2 0 0 2 2 2 1 Toluene tolerance, Ttg2 DUF3106 PF11304.3 ESA23681.1 - 0.0097 16.3 1.2 2 8.8 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3106) DUF1289 PF06945.8 ESA23681.1 - 0.097 12.1 3.4 2.2 7.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) BRE1 PF08647.6 ESA23682.1 - 0.025 14.5 1.8 0.031 14.2 1.2 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase MS_channel PF00924.13 ESA23682.1 - 0.048 12.9 0.1 0.048 12.9 0.1 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel Swi5 PF07061.6 ESA23682.1 - 0.12 12.1 0.3 0.15 11.8 0.2 1.2 1 0 0 1 1 1 0 Swi5 Novirhabdo_Nv PF05554.6 ESA23683.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein zf-C3HC4_2 PF13923.1 ESA23684.1 - 0.0056 16.6 3.0 0.016 15.2 1.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA23684.1 - 0.011 15.6 6.1 0.013 15.3 1.1 2.6 3 0 0 3 3 3 0 Ring finger domain zf-rbx1 PF12678.2 ESA23684.1 - 0.022 14.8 1.7 0.059 13.4 0.4 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger Ima1_N PF09779.4 ESA23684.1 - 0.055 13.9 0.2 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Ima1 N-terminal domain zf-RING_5 PF14634.1 ESA23684.1 - 0.59 9.9 5.2 0.17 11.6 1.3 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA23684.1 - 0.59 9.8 5.2 0.15 11.7 0.9 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23684.1 - 8 6.2 9.0 0.21 11.2 1.8 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF383 PF04063.9 ESA23685.1 - 0.19 11.2 4.3 0.13 11.8 0.7 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF383) EcoR124_C PF12008.3 ESA23686.1 - 0.068 12.3 1.5 0.091 11.9 1.0 1.2 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal DUF725 PF05267.7 ESA23686.1 - 0.11 12.4 0.7 8 6.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF725) DUF1232 PF06803.7 ESA23687.1 - 0.14 11.6 1.7 0.26 10.7 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1232) DUF1707 PF08044.6 ESA23687.1 - 0.14 11.8 1.9 0.26 11.0 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) UQ_con PF00179.21 ESA23688.1 - 2e-38 130.9 0.0 2.2e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 ESA23688.1 - 0.053 13.2 0.0 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic E2 family B UEV PF05743.8 ESA23688.1 - 0.081 12.6 0.2 0.15 11.7 0.1 1.5 1 1 0 1 1 1 0 UEV domain UQ_con PF00179.21 ESA23689.1 - 6.6e-43 145.5 0.0 7.6e-43 145.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 ESA23689.1 - 0.00021 20.9 0.0 0.00034 20.2 0.0 1.4 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 ESA23689.1 - 0.034 14.0 0.1 0.038 13.8 0.1 1.5 1 1 0 1 1 1 0 RWD domain PPTA PF01239.17 ESA23690.1 - 2.3e-42 140.5 15.5 1e-08 34.1 0.0 6.1 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat zf-H2C2_2 PF13465.1 ESA23691.1 - 8.6e-48 158.3 72.5 1.6e-07 31.2 0.8 11.8 12 0 0 12 12 12 9 Zinc-finger double domain zf-C2H2 PF00096.21 ESA23691.1 - 2.4e-45 150.2 62.6 2.9e-05 24.1 0.4 10.7 11 0 0 11 11 11 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA23691.1 - 3.3e-36 120.9 45.1 0.0014 18.8 0.2 10.3 10 0 0 10 10 10 10 C2H2-type zinc finger zf-C2H2_6 PF13912.1 ESA23691.1 - 3.8e-09 36.1 38.4 0.00063 19.5 0.1 9.2 10 0 0 10 10 10 5 C2H2-type zinc finger zf-met PF12874.2 ESA23691.1 - 5.4e-05 23.2 39.5 3.4 7.9 0.8 10.0 10 0 0 10 10 10 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 ESA23691.1 - 0.019 15.1 39.9 0.091 12.9 0.1 8.6 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 ESA23691.1 - 8.4 6.7 42.5 4.8 7.4 0.5 8.8 4 4 5 9 9 9 0 CHORD MRG PF05712.8 ESA23692.1 - 1.3e-47 161.2 0.4 1.9e-47 160.7 0.2 1.1 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 ESA23692.1 - 9.1e-09 34.8 0.2 1.9e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 ESA23692.1 - 0.036 13.7 0.2 0.13 11.9 0.1 2.0 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain SAYSvFN PF10260.4 ESA23693.1 - 0.016 14.9 0.3 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) PI-PLC-X PF00388.14 ESA23693.1 - 0.09 12.1 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Y_phosphatase3 PF13350.1 ESA23695.1 - 2e-42 145.2 0.0 3.6e-42 144.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_6 PF12697.2 ESA23695.1 - 2.1e-14 53.9 0.0 3e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA23695.1 - 1.4e-11 44.3 0.0 2.2e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Y_phosphatase3C PF13348.1 ESA23695.1 - 2.8e-07 30.5 0.0 8.5e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Abhydrolase_1 PF00561.15 ESA23695.1 - 5e-06 26.2 0.1 0.0035 16.9 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Y_phosphatase2 PF03162.8 ESA23695.1 - 1.3e-05 24.6 3.2 0.00049 19.4 0.1 2.9 3 0 0 3 3 3 1 Tyrosine phosphatase family DUF915 PF06028.6 ESA23695.1 - 0.0012 18.0 0.2 0.0046 16.0 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S9 PF00326.16 ESA23695.1 - 0.014 14.6 0.1 0.035 13.3 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family FrhB_FdhB_C PF04432.8 ESA23695.1 - 0.033 13.6 0.3 0.99 8.7 0.0 2.3 2 0 0 2 2 2 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus DUF1749 PF08538.5 ESA23695.1 - 0.035 12.9 0.0 0.13 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) DUF3832 PF12909.2 ESA23695.1 - 0.036 14.1 2.1 0.082 12.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3832) PhoPQ_related PF10142.4 ESA23695.1 - 0.048 12.1 0.4 0.084 11.3 0.3 1.3 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein UCH PF00443.24 ESA23695.1 - 0.07 12.2 2.1 0.28 10.2 0.2 2.2 1 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase GBP_repeat PF02526.9 ESA23696.1 - 0.07 12.5 0.2 2.5 7.5 0.0 2.5 2 0 0 2 2 2 0 Glycophorin-binding protein PIN_2 PF10130.4 ESA23696.1 - 0.076 13.0 0.1 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 PIN domain Alpha_kinase PF02816.13 ESA23698.1 - 5.7e-39 133.7 0.2 1.2e-38 132.6 0.1 1.6 1 0 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 ESA23698.1 - 0.00011 22.4 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DNA_pol3_a_NII PF11490.3 ESA23698.1 - 0.045 13.3 2.3 0.54 9.8 0.2 2.7 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II DUF3617 PF12276.3 ESA23699.1 - 0.16 11.3 1.6 0.21 11.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) Spatacsin_C PF14649.1 ESA23700.1 - 0.008 15.0 5.3 0.016 14.0 3.6 1.4 1 1 0 1 1 1 1 Spatacsin C-terminus Peptidase_S76 PF13611.1 ESA23700.1 - 0.036 14.1 0.7 0.069 13.2 0.5 1.5 1 0 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 SAB PF04382.8 ESA23700.1 - 3.2 7.5 7.0 0.39 10.4 0.7 2.6 3 0 0 3 3 3 0 SAB domain FAR1 PF03101.10 ESA23701.1 - 6.3e-11 42.6 0.7 1.9e-10 41.1 0.5 1.9 1 0 0 1 1 1 1 FAR1 DNA-binding domain IKI3 PF04762.7 ESA23702.1 - 0.0041 15.0 0.2 0.005 14.7 0.1 1.1 1 0 0 1 1 1 1 IKI3 family Tricorn_C1 PF14684.1 ESA23702.1 - 0.098 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Tricorn protease C1 domain Myb_DNA-binding PF00249.26 ESA23703.1 - 2.4e-18 65.8 3.2 5.5e-10 39.1 0.4 3.2 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA23703.1 - 2.7e-14 52.9 2.2 2.1e-06 27.7 0.1 2.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain RICTOR_phospho PF14665.1 ESA23703.1 - 0.087 12.9 1.7 0.17 11.9 1.1 1.5 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site Laminin_G_3 PF13385.1 ESA23704.1 - 1.2e-12 48.3 0.7 3.1e-12 47.0 0.0 2.0 3 1 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily MIR PF02815.14 ESA23704.1 - 1.1e-08 34.8 0.1 2.9e-06 26.9 0.0 2.3 1 1 1 2 2 2 2 MIR domain Ins145_P3_rec PF08709.6 ESA23704.1 - 0.00068 18.7 0.1 0.0015 17.5 0.0 1.5 1 1 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor TPK_B1_binding PF04265.9 ESA23704.1 - 0.031 13.9 0.0 0.096 12.4 0.0 1.9 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain Botulinum_HA-17 PF05588.6 ESA23704.1 - 0.065 13.1 0.2 0.75 9.6 0.0 2.3 2 0 0 2 2 2 0 Clostridium botulinum HA-17 protein MAGSP PF03082.9 ESA23705.1 - 0.15 11.4 0.5 0.22 10.8 0.4 1.2 1 0 0 1 1 1 0 Male accessory gland secretory protein DUF2874 PF11396.3 ESA23706.1 - 1.2 9.1 5.9 2.2 8.2 0.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2874) MIF4G_like_2 PF09090.6 ESA23707.1 - 6e-53 179.6 5.8 1.2e-52 178.6 4.0 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.6 ESA23707.1 - 1.6e-51 174.4 10.3 9e-50 168.7 4.6 4.0 3 1 0 3 3 3 1 MIF4G like MIF4G PF02854.14 ESA23707.1 - 4.8e-16 58.8 0.9 1.7e-15 57.0 0.1 2.3 2 0 0 2 2 2 1 MIF4G domain DUF3500 PF12006.3 ESA23707.1 - 0.0037 16.2 0.1 0.0074 15.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) Gemini_AL3 PF01407.12 ESA23707.1 - 0.011 15.1 2.0 0.33 10.4 0.8 2.7 2 0 0 2 2 2 0 Geminivirus AL3 protein MNE1 PF13762.1 ESA23707.1 - 0.057 13.4 1.3 0.11 12.5 0.3 2.0 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component zf-H2C2 PF09337.5 ESA23707.1 - 0.15 11.4 0.5 0.59 9.5 0.1 2.2 2 0 0 2 2 2 0 His(2)-Cys(2) zinc finger 2OG-FeII_Oxy_2 PF13532.1 ESA23708.1 - 4.4e-19 69.0 0.0 2.7e-16 59.9 0.0 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESA23708.1 - 2.8e-08 33.9 0.0 3.7e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ndc1_Nup PF09531.5 ESA23710.1 - 2.5e-37 128.6 16.9 9e-25 87.1 10.6 2.2 2 0 0 2 2 2 2 Nucleoporin protein Ndc1-Nup HTH_38 PF13936.1 ESA23711.1 - 3e-09 36.2 0.0 5.6e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.1 ESA23711.1 - 4.5e-07 29.9 0.0 5.8e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_Tc3_2 PF01498.13 ESA23711.1 - 2.5e-05 24.2 0.1 0.00021 21.3 0.0 2.0 2 0 0 2 2 2 1 Transposase HTH_28 PF13518.1 ESA23711.1 - 3.5e-05 23.6 0.0 5.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.1 ESA23711.1 - 4.5e-05 22.9 0.0 6.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain MarR PF01047.17 ESA23711.1 - 0.00012 21.7 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 MarR family Terminase_5 PF06056.7 ESA23711.1 - 0.00079 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) KorB PF08535.5 ESA23711.1 - 0.0066 16.5 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 KorB domain MarR_2 PF12802.2 ESA23711.1 - 0.0085 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_Tnp_Tc3_1 PF11427.3 ESA23711.1 - 0.012 15.2 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 0 Tc3 transposase HTH_40 PF14493.1 ESA23711.1 - 0.049 13.8 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.7 ESA23711.1 - 0.083 12.3 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_32 PF13565.1 ESA23711.1 - 0.085 13.6 0.0 0.23 12.2 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain DUF1992 PF09350.5 ESA23711.1 - 0.096 12.5 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) Flu_PA PF00603.12 ESA23711.1 - 0.1 10.5 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PA DUF31 PF01732.11 ESA23712.1 - 0.023 14.0 2.5 0.11 11.8 0.1 2.0 1 1 1 2 2 2 0 Putative peptidase (DUF31) Cofilin_ADF PF00241.15 ESA23713.1 - 0.095 12.5 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Pkinase_Tyr PF07714.12 ESA23716.1 - 2.6e-39 134.8 0.0 5.1e-39 133.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23716.1 - 3.2e-38 131.3 0.1 6.9e-38 130.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF3279 PF11682.3 ESA23716.1 - 0.011 15.2 0.8 0.011 15.2 0.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3279) DUF3897 PF13036.1 ESA23716.1 - 0.098 12.2 0.8 2.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3897) HypA PF01155.14 ESA23716.1 - 2.5 7.8 14.7 6 6.5 0.0 4.3 3 1 1 4 4 4 0 Hydrogenase expression/synthesis hypA family Pkinase_Tyr PF07714.12 ESA23717.1 - 6e-09 35.3 0.0 0.73 8.8 0.0 4.3 4 0 0 4 4 4 4 Protein tyrosine kinase BCS1_N PF08740.6 ESA23717.1 - 1.2e-08 34.7 0.1 0.0037 16.8 0.0 3.2 3 0 0 3 3 3 2 BCS1 N terminal DUF760 PF05542.6 ESA23717.1 - 0.012 15.7 0.0 6.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF760) DUF4413 PF14372.1 ESA23717.1 - 0.03 14.3 5.9 11 6.0 0.1 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) DUF2789 PF10982.3 ESA23717.1 - 0.59 10.1 5.2 39 4.3 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF2789) zf-ribbon_3 PF13248.1 ESA23717.1 - 0.73 9.1 15.1 1.9 7.7 0.0 4.1 4 0 0 4 4 4 0 zinc-ribbon domain DUF4047 PF13256.1 ESA23717.1 - 1.6 8.6 11.4 0.77 9.7 0.3 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4047) CheR PF01739.13 ESA23718.1 - 2.1e-07 30.4 0.0 3.1e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_11 PF08241.7 ESA23718.1 - 0.00012 22.5 0.0 0.00019 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 ESA23718.1 - 0.00086 18.9 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 ESA23718.1 - 0.0063 16.2 0.0 0.0078 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 ESA23718.1 - 0.033 14.6 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Ly49 PF08391.5 ESA23718.1 - 0.07 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Methyltransf_25 PF13649.1 ESA23718.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain HSP70 PF00012.15 ESA23721.1 - 3.7e-226 751.7 5.3 4.2e-226 751.5 3.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 ESA23721.1 - 1.4e-16 60.0 0.1 2.4e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 ESA23721.1 - 0.00021 20.9 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 ESA23721.1 - 0.012 14.7 0.0 0.3 10.1 0.0 2.4 1 1 1 2 2 2 0 Hydantoinase/oxoprolinase PMBR PF09373.5 ESA23721.1 - 0.038 13.9 0.1 0.038 13.9 0.1 2.3 2 0 0 2 2 2 0 Pseudomurein-binding repeat BcrAD_BadFG PF01869.15 ESA23721.1 - 0.065 12.5 0.1 0.17 11.1 0.0 1.7 1 1 1 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family zf-C4pol PF14260.1 ESA23722.1 - 0.08 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta BTB PF00651.26 ESA23723.1 - 1.2e-13 51.0 0.4 8.7e-13 48.2 0.0 2.2 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA23723.1 - 2.6e-10 40.0 2.4 5.5e-09 35.7 0.6 3.1 1 1 2 3 3 3 1 BTB And C-terminal Kelch Pept_tRNA_hydro PF01195.14 ESA23723.1 - 0.097 12.1 0.0 0.2 11.1 0.0 1.7 1 1 0 1 1 1 0 Peptidyl-tRNA hydrolase BTB PF00651.26 ESA23724.1 - 8.9e-16 57.8 1.2 8.4e-14 51.5 0.2 2.5 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.10 ESA23724.1 - 2.6e-11 43.2 10.8 1.6e-10 40.7 0.7 3.5 2 1 2 4 4 4 2 BTB And C-terminal Kelch Ribonuclease_3 PF00636.21 ESA23725.1 - 5.8e-11 42.8 0.5 5.8e-11 42.8 0.4 3.1 2 2 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 ESA23725.1 - 4.6e-08 33.0 0.1 2.3e-07 30.8 0.0 2.2 2 1 0 2 2 2 1 Ribonuclease-III-like DLIC PF05783.6 ESA23725.1 - 0.002 16.9 2.9 0.065 11.9 0.2 2.2 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) BTB PF00651.26 ESA23726.1 - 2.9e-19 69.1 1.0 1.2e-18 67.0 0.1 2.3 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.10 ESA23726.1 - 8.8e-07 28.7 0.3 1.2e-05 25.1 0.0 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch DUF972 PF06156.8 ESA23727.1 - 0.0046 17.2 4.5 0.0046 17.2 3.1 3.9 2 2 2 4 4 4 1 Protein of unknown function (DUF972) DUF972 PF06156.8 ESA23728.1 - 6.1e-05 23.3 5.7 6.1e-05 23.3 4.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF972) CASP_C PF08172.7 ESA23728.1 - 0.0016 17.5 14.4 0.013 14.5 0.5 2.6 2 1 0 2 2 2 2 CASP C terminal BRE1 PF08647.6 ESA23728.1 - 0.0023 17.8 7.6 0.0023 17.8 5.3 2.2 2 1 0 2 2 2 1 BRE1 E3 ubiquitin ligase DUF904 PF06005.7 ESA23728.1 - 0.025 14.8 4.5 0.025 14.8 3.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF904) bZIP_2 PF07716.10 ESA23728.1 - 0.075 12.8 12.0 0.29 10.9 0.4 3.6 2 1 1 3 3 3 0 Basic region leucine zipper ADIP PF11559.3 ESA23728.1 - 0.37 10.6 15.9 0.027 14.3 5.4 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Pox_A_type_inc PF04508.7 ESA23728.1 - 0.49 10.3 8.5 0.46 10.3 0.7 3.3 2 1 0 2 2 2 0 Viral A-type inclusion protein repeat TMF_TATA_bd PF12325.3 ESA23728.1 - 1.5 8.6 15.4 0.067 12.9 6.5 1.8 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding MutS_IV PF05190.13 ESA23728.1 - 2.3 8.4 7.1 6.5 7.0 0.2 2.8 2 1 0 2 2 2 0 MutS family domain IV DUF2762 PF10960.3 ESA23728.1 - 9.2 6.0 9.9 13 5.6 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2762) ABC2_membrane PF01061.19 ESA23730.1 - 6.4e-19 67.9 13.9 9.4e-19 67.4 9.6 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 ESA23730.1 - 7.4e-07 28.5 10.8 8.7e-07 28.2 7.5 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 ESA23730.1 - 0.00013 20.9 6.1 0.00015 20.7 4.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 ESA23730.1 - 0.31 10.1 16.5 0.29 10.2 9.3 1.9 2 0 0 2 2 2 0 ABC-2 family transporter protein HSP70 PF00012.15 ESA23731.1 - 1.1e-89 300.9 7.5 3.9e-53 180.3 0.1 4.0 1 1 3 4 4 4 4 Hsp70 protein FGGY_C PF02782.11 ESA23731.1 - 0.0014 18.2 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain MreB_Mbl PF06723.8 ESA23731.1 - 0.019 13.5 0.0 0.065 11.8 0.0 1.8 1 1 1 2 2 2 0 MreB/Mbl protein DUF4445 PF14574.1 ESA23731.1 - 0.05 11.8 0.1 0.095 10.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4445) PMBR PF09373.5 ESA23731.1 - 0.096 12.6 0.2 0.29 11.1 0.1 1.9 1 0 0 1 1 1 0 Pseudomurein-binding repeat Pox_A_type_inc PF04508.7 ESA23732.1 - 0.38 10.6 2.6 0.56 10.1 0.3 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat TSC22 PF01166.13 ESA23732.1 - 0.38 10.7 0.3 0.38 10.7 0.2 1.7 2 0 0 2 2 2 0 TSC-22/dip/bun family Myb_DNA-binding PF00249.26 ESA23735.1 - 0.017 15.1 2.1 0.62 10.1 0.2 2.8 2 0 0 2 2 2 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 ESA23735.1 - 0.078 13.0 0.2 0.078 13.0 0.1 2.7 2 1 1 3 3 3 0 Myb-like DNA-binding domain DUF659 PF04937.10 ESA23738.1 - 4e-10 39.3 1.2 5.9e-10 38.8 0.4 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF 659) DUF3793 PF12672.2 ESA23739.1 - 0.046 13.3 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Staygreen PF12638.2 ESA23739.1 - 0.046 13.2 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Staygreen protein MBOAT_2 PF13813.1 ESA23740.1 - 4.1e-10 39.5 0.3 4.1e-10 39.5 0.2 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family DUF939 PF06081.6 ESA23740.1 - 0.043 13.6 6.3 0.11 12.3 0.2 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF939) AAA PF00004.24 ESA23741.1 - 4.2e-18 65.8 0.4 1.6e-17 63.9 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 ESA23741.1 - 9e-06 25.7 0.0 2.6e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 ESA23741.1 - 1.7e-05 23.9 0.0 1.7e-05 23.9 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 ESA23741.1 - 2e-05 24.6 0.8 7.9e-05 22.7 0.0 2.4 2 1 0 2 2 2 1 RNA helicase AAA_5 PF07728.9 ESA23741.1 - 8.9e-05 22.2 0.2 0.0017 18.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESA23741.1 - 0.00011 22.9 0.6 0.0016 19.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA23741.1 - 0.00016 22.0 0.0 0.00016 22.0 0.0 2.6 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 ESA23741.1 - 0.0002 20.5 0.0 0.00036 19.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 ESA23741.1 - 0.0003 20.4 0.6 0.0007 19.2 0.4 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 ESA23741.1 - 0.00056 20.0 0.0 0.0027 17.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 ESA23741.1 - 0.00091 18.0 0.0 0.00091 18.0 0.0 1.9 2 1 1 3 3 3 1 TIP49 C-terminus AAA_23 PF13476.1 ESA23741.1 - 0.001 19.4 8.8 0.0016 18.7 5.8 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.1 ESA23741.1 - 0.0018 18.1 1.3 0.016 15.0 0.0 2.4 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 ESA23741.1 - 0.0032 17.3 0.6 0.0061 16.4 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.1 ESA23741.1 - 0.0046 16.5 0.1 0.012 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 ESA23741.1 - 0.0047 16.6 0.0 0.0047 16.6 0.0 2.6 1 1 0 2 2 2 1 Archaeal ATPase AAA_19 PF13245.1 ESA23741.1 - 0.0049 16.5 0.0 0.0078 15.9 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain DUF2317 PF10079.4 ESA23741.1 - 0.0068 15.0 1.1 0.01 14.4 0.7 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2317) Zeta_toxin PF06414.7 ESA23741.1 - 0.0098 15.0 0.0 0.024 13.7 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.1 ESA23741.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain KaiC PF06745.8 ESA23741.1 - 0.012 14.6 0.6 0.086 11.9 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_21 PF13304.1 ESA23741.1 - 0.015 15.2 3.8 0.023 14.6 0.2 2.2 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 ESA23741.1 - 0.016 14.2 0.0 0.018 14.0 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain ResIII PF04851.10 ESA23741.1 - 0.017 14.9 2.3 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MCM PF00493.18 ESA23741.1 - 0.019 13.7 0.0 0.036 12.8 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family Bac_DnaA PF00308.13 ESA23741.1 - 0.026 14.1 0.1 0.062 12.9 0.0 1.7 2 0 0 2 2 1 0 Bacterial dnaA protein Sigma54_activ_2 PF14532.1 ESA23741.1 - 0.028 14.4 0.0 0.08 12.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF258 PF03193.11 ESA23741.1 - 0.032 13.4 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 ESA23741.1 - 0.049 13.2 0.0 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.1 ESA23741.1 - 0.063 13.2 0.9 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 ESA23741.1 - 0.069 12.0 0.0 0.13 11.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.12 ESA23741.1 - 0.071 12.5 0.1 0.18 11.1 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.1 ESA23741.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 ESA23741.1 - 0.13 12.7 2.2 0.42 11.1 0.0 2.4 2 1 0 2 2 2 0 Miro-like protein ABC_tran PF00005.22 ESA23741.1 - 0.23 11.7 6.3 5.5 7.2 4.3 2.7 1 1 0 1 1 1 0 ABC transporter MFS_1 PF07690.11 ESA23742.1 - 4.1e-16 58.6 20.4 5.6e-16 58.2 14.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_5 PF06946.6 ESA23742.1 - 0.033 14.3 1.0 0.26 11.5 0.7 2.4 1 1 0 1 1 1 0 Phage holin Mob1_phocein PF03637.12 ESA23743.1 - 1.4e-42 145.3 1.4 1.8e-42 144.9 1.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family P21-Arc PF04062.9 ESA23744.1 - 3e-79 264.8 0.1 3.4e-79 264.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit dCMP_cyt_deam_1 PF00383.17 ESA23745.1 - 1.1e-19 70.0 0.4 1.3e-19 69.7 0.3 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 ESA23745.1 - 3.7e-05 23.4 0.0 5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain XOO_2897-deam PF14440.1 ESA23745.1 - 0.004 16.8 0.1 0.0051 16.5 0.1 1.2 1 0 0 1 1 1 1 Xanthomonas XOO_2897-like deaminase Ras PF00071.17 ESA23746.1 - 7e-48 162.0 0.4 8.1e-48 161.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA23746.1 - 1.5e-15 57.6 0.1 2.2e-15 57.2 0.1 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 ESA23746.1 - 2.5e-07 30.3 0.2 4.7e-06 26.1 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.16 ESA23746.1 - 2e-06 27.1 0.0 2.4e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 ESA23746.1 - 4.3e-05 23.4 0.1 6.5e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 ESA23746.1 - 0.00031 20.0 0.0 0.0048 16.1 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Arch_ATPase PF01637.13 ESA23746.1 - 0.0036 17.0 0.1 0.013 15.2 0.1 2.1 1 1 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 ESA23746.1 - 0.018 14.9 0.0 0.029 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 ESA23746.1 - 0.07 13.1 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain HECT PF00632.20 ESA23748.1 - 1.8e-57 194.9 0.6 2.5e-57 194.4 0.4 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 ESA23748.1 - 9.8e-34 114.8 21.7 7e-11 41.7 0.2 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.25 ESA23748.1 - 1.2e-16 60.3 0.3 2.9e-16 59.0 0.2 1.7 1 0 0 1 1 1 1 C2 domain Pkinase PF00069.20 ESA23751.1 - 1.6e-46 158.6 0.1 2.7e-46 157.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23751.1 - 1.3e-44 152.1 0.0 1.7e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF713 PF05218.9 ESA23751.1 - 0.05 13.3 1.9 0.18 11.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF713) BTB PF00651.26 ESA23752.1 - 1.5e-15 57.1 1.0 3.1e-15 56.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23752.1 - 3.6e-15 56.1 0.3 3.6e-15 56.1 0.2 2.1 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA23752.1 - 0.00062 19.5 2.0 0.0026 17.5 0.7 2.6 1 1 0 1 1 1 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA23753.1 - 0.00081 18.5 0.0 0.0046 16.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Cyc-maltodext_C PF10438.4 ESA23753.1 - 0.51 10.4 8.5 3.7 7.6 0.1 3.3 3 1 0 3 3 3 0 Cyclo-malto-dextrinase C-terminal domain Aldo_ket_red PF00248.16 ESA23754.1 - 2.8e-64 216.6 0.0 3.3e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.16 ESA23755.1 - 2.8e-65 219.9 0.0 3.3e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3782 PF12644.2 ESA23755.1 - 0.12 12.1 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Methyltransf_31 PF13847.1 ESA23756.1 - 7.4e-05 22.3 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 ESA23756.1 - 0.00096 19.4 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 ESA23756.1 - 0.0017 17.4 0.0 0.0028 16.7 0.0 1.3 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 ESA23756.1 - 0.008 15.9 0.0 0.0095 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 ESA23756.1 - 0.0096 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 ESA23756.1 - 0.018 15.6 0.0 0.031 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 ESA23756.1 - 0.12 11.4 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 ESA23756.1 - 0.14 12.6 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Caveolin PF01146.12 ESA23758.1 - 1.6 8.2 7.4 2.6 7.6 5.1 1.3 1 0 0 1 1 1 0 Caveolin DUF4229 PF14012.1 ESA23758.1 - 5.7 6.9 7.8 1.3 9.0 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) BTB PF00651.26 ESA23762.1 - 2.8e-17 62.6 0.1 5e-17 61.8 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA23762.1 - 2.8e-12 46.7 0.4 9.7e-12 45.0 0.2 2.0 2 0 0 2 2 2 1 TLD BACK PF07707.10 ESA23762.1 - 0.014 15.2 1.5 0.86 9.4 0.2 3.1 1 1 1 2 2 2 0 BTB And C-terminal Kelch Pkinase_Tyr PF07714.12 ESA23763.1 - 3.1e-14 52.6 0.0 4.8e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23763.1 - 2.8e-11 43.0 0.0 5.4e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Sel1 PF08238.7 ESA23763.1 - 5.8e-09 36.3 0.3 9.8e-06 26.0 0.1 2.5 2 0 0 2 2 2 2 Sel1 repeat Ribosomal_S15 PF00312.17 ESA23763.1 - 0.045 13.5 0.7 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein S15 SPATIAL PF15256.1 ESA23765.1 - 0.021 14.8 0.1 0.03 14.3 0.1 1.2 1 0 0 1 1 1 0 SPATIAL TLD PF07534.11 ESA23766.1 - 2e-06 27.8 2.6 2.5e-06 27.5 1.8 1.1 1 0 0 1 1 1 1 TLD Steroid_dh PF02544.11 ESA23767.1 - 0.0051 16.5 0.0 0.013 15.2 0.0 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ricin_B_lectin PF00652.17 ESA23767.1 - 0.02 14.9 0.4 0.033 14.2 0.3 1.3 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain DUF2726 PF10881.3 ESA23767.1 - 0.063 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) BTB PF00651.26 ESA23768.1 - 1.1e-19 70.4 0.0 2.2e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA23768.1 - 1.3e-13 51.1 0.6 2.7e-13 50.1 0.4 1.5 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA23768.1 - 0.00087 19.0 0.1 0.0077 16.0 0.1 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch adh_short_C2 PF13561.1 ESA23769.1 - 2.5e-35 122.4 0.0 3.3e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 ESA23769.1 - 6.5e-26 91.2 0.0 8.3e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 ESA23769.1 - 8.6e-10 38.5 0.0 1.2e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 ESA23769.1 - 0.019 14.1 0.1 0.027 13.5 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ATP_bind_2 PF03668.10 ESA23769.1 - 0.083 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 P-loop ATPase protein family RhoGAP PF00620.22 ESA23770.1 - 7.3e-45 152.2 0.0 8e-45 152.1 0.0 1.0 1 0 0 1 1 1 1 RhoGAP domain DNA_ligase_A_N PF04675.9 ESA23770.1 - 0.068 12.9 0.0 0.085 12.6 0.0 1.1 1 0 0 1 1 1 0 DNA ligase N terminus DUF2096 PF09869.4 ESA23770.1 - 0.12 12.2 0.2 0.14 11.9 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) zf-C2H2_4 PF13894.1 ESA23771.1 - 0.0011 19.1 1.1 0.0011 19.1 0.7 2.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA23771.1 - 0.027 14.7 0.3 0.027 14.7 0.2 2.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2 PF00096.21 ESA23771.1 - 3.5 8.1 10.3 0.2 12.0 1.3 2.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 ESA23771.1 - 4 7.7 6.6 10 6.4 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding BTB PF00651.26 ESA23772.1 - 4.6e-17 62.0 0.3 1.5e-16 60.3 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 ESA23772.1 - 0.00016 21.4 1.5 0.00068 19.4 0.3 2.4 1 1 0 1 1 1 1 BTB And C-terminal Kelch DUF3684 PF12449.3 ESA23773.1 - 1.1e-251 837.8 4.5 1.4e-251 837.5 3.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) DUF261 PF03196.8 ESA23773.1 - 0.0084 16.0 1.5 0.04 13.8 0.1 2.7 3 0 0 3 3 3 1 Protein of unknown function, DUF261 CUE PF02845.11 ESA23773.1 - 0.017 14.6 0.3 0.063 12.7 0.0 2.1 2 0 0 2 2 2 0 CUE domain WLM PF08325.5 ESA23773.1 - 0.031 14.1 1.2 0.09 12.6 0.9 1.7 1 0 0 1 1 1 0 WLM domain DUF615 PF04751.9 ESA23773.1 - 0.23 11.0 3.5 0.26 10.9 0.1 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF615) BTB PF00651.26 ESA23774.1 - 8.5e-20 70.8 2.1 3.9e-19 68.6 0.5 2.2 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.23 ESA23774.1 - 1.3e-12 47.9 0.1 2.2e-12 47.1 0.1 1.4 1 0 0 1 1 1 1 SPRY domain HeLo PF14479.1 ESA23778.1 - 0.042 13.5 5.9 0.11 12.2 4.1 1.7 1 0 0 1 1 1 0 Prion-inhibition and propagation Tropomyosin_1 PF12718.2 ESA23778.1 - 0.17 11.7 15.2 0.02 14.7 5.5 2.4 1 1 1 2 2 2 0 Tropomyosin like IncA PF04156.9 ESA23778.1 - 0.52 9.8 7.6 1.1 8.8 5.2 1.5 1 0 0 1 1 1 0 IncA protein Rootletin PF15035.1 ESA23778.1 - 0.8 9.6 16.6 0.08 12.9 7.4 2.2 3 0 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion FlxA PF14282.1 ESA23778.1 - 2.6 8.0 14.3 1.4 8.9 4.3 3.0 2 1 0 2 2 2 0 FlxA-like protein DUF4140 PF13600.1 ESA23778.1 - 4.4 7.7 5.9 21 5.6 0.5 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TSC22 PF01166.13 ESA23779.1 - 0.0035 17.2 1.9 0.11 12.4 0.1 2.7 2 0 0 2 2 2 1 TSC-22/dip/bun family Cep57_CLD_2 PF14197.1 ESA23779.1 - 0.0046 16.8 3.4 0.0079 16.1 0.8 2.4 2 0 0 2 2 2 1 Centrosome localisation domain of PPC89 ECSIT PF06239.6 ESA23779.1 - 0.012 14.5 1.4 0.02 13.7 0.4 1.7 1 1 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway DUF972 PF06156.8 ESA23779.1 - 0.15 12.3 11.8 0.22 11.8 2.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF2205 PF10224.4 ESA23779.1 - 0.52 9.9 13.3 2.2 7.9 0.2 3.9 2 2 2 4 4 4 0 Predicted coiled-coil protein (DUF2205) DivIC PF04977.10 ESA23779.1 - 1.3 8.6 6.5 0.3 10.6 0.3 2.8 2 1 0 3 3 3 0 Septum formation initiator DUF904 PF06005.7 ESA23779.1 - 8.7 6.7 12.0 0.33 11.2 1.8 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF904) HSP70 PF00012.15 ESA23780.1 - 3.1e-05 22.0 0.0 0.0013 16.7 0.0 2.7 3 0 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 ESA23781.1 - 0.001 17.7 0.0 0.015 13.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein HSP70 PF00012.15 ESA23781.1 - 0.0011 16.9 0.0 2.8 5.7 0.0 3.0 3 0 0 3 3 3 3 Hsp70 protein DRTGG PF07085.7 ESA23781.1 - 0.016 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 DRTGG domain HSP70 PF00012.15 ESA23782.1 - 7.4e-06 24.1 0.0 0.00085 17.3 0.0 2.8 2 1 0 2 2 2 2 Hsp70 protein PARP PF00644.15 ESA23784.1 - 1.1e-15 57.5 4.7 1.1e-13 51.0 0.3 2.6 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain DUF371 PF04027.8 ESA23784.1 - 0.059 13.0 0.1 12 5.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF371) HSP70 PF00012.15 ESA23785.1 - 0.00016 19.7 0.0 0.00096 17.1 0.0 2.0 1 1 0 1 1 1 1 Hsp70 protein Pkinase_Tyr PF07714.12 ESA23787.1 - 1.4e-21 76.7 7.1 7.6e-21 74.3 0.1 3.5 3 2 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 ESA23787.1 - 1.3e-19 70.3 1.4 1.3e-19 70.3 1.0 3.2 3 0 0 3 3 3 1 Protein kinase domain HpaB_N PF11794.3 ESA23787.1 - 0.0001 21.7 4.7 2.2 7.6 0.0 5.1 5 0 0 5 5 5 2 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF1653 PF07866.6 ESA23787.1 - 0.045 13.9 0.6 2 8.6 0.1 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1653) DUF2789 PF10982.3 ESA23787.1 - 0.045 13.7 0.5 12 6.0 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2789) Arch_ATPase PF01637.13 ESA23788.1 - 2.5e-07 30.6 0.0 3.1e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 ESA23788.1 - 1.9e-06 28.0 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 ESA23788.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 ESA23788.1 - 0.018 15.2 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 ESA23788.1 - 0.025 14.2 0.2 0.075 12.7 0.1 1.8 1 1 1 2 2 2 0 Part of AAA domain AAA_11 PF13086.1 ESA23788.1 - 0.039 13.5 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.10 ESA23788.1 - 0.11 11.1 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein Zeta_toxin PF06414.7 ESA23788.1 - 0.12 11.4 0.0 0.3 10.1 0.0 1.6 1 1 1 2 2 2 0 Zeta toxin HMG_box PF00505.14 ESA23789.1 - 4.4e-05 23.6 0.6 8.2e-05 22.7 0.3 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23789.1 - 0.0016 18.7 0.2 0.0027 18.0 0.1 1.4 1 0 0 1 1 1 1 HMG-box domain FHIPEP PF00771.15 ESA23790.1 - 0.13 10.5 1.4 0.17 10.1 1.0 1.1 1 0 0 1 1 1 0 FHIPEP family Pkinase_Tyr PF07714.12 ESA23792.1 - 4.6e-36 124.2 0.0 6.1e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23792.1 - 1.6e-33 115.9 0.0 2.4e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CENP-Q PF13094.1 ESA23793.1 - 0.00042 20.3 10.8 0.00053 20.0 7.5 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Med9 PF07544.8 ESA23793.1 - 0.0019 17.8 8.6 0.0019 17.8 5.0 1.7 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 GrpE PF01025.14 ESA23793.1 - 0.0038 16.7 7.8 0.005 16.3 5.4 1.1 1 0 0 1 1 1 1 GrpE Laminin_II PF06009.7 ESA23793.1 - 0.004 16.9 4.6 0.005 16.5 3.2 1.3 1 0 0 1 1 1 1 Laminin Domain II LmjF365940-deam PF14421.1 ESA23793.1 - 0.0048 16.2 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases DUF2203 PF09969.4 ESA23793.1 - 0.0063 16.7 4.9 0.0067 16.6 2.8 1.5 1 1 1 2 2 1 1 Uncharacterized conserved protein (DUF2203) Laminin_I PF06008.9 ESA23793.1 - 0.025 13.8 6.0 0.031 13.5 4.1 1.1 1 0 0 1 1 1 0 Laminin Domain I Spc7 PF08317.6 ESA23793.1 - 0.034 12.7 8.9 0.036 12.7 6.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Vps53_N PF04100.7 ESA23793.1 - 0.036 12.8 3.4 0.038 12.7 2.3 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal DUF2730 PF10805.3 ESA23793.1 - 0.048 13.3 3.0 0.15 11.8 2.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) THP2 PF09432.5 ESA23793.1 - 0.065 13.1 4.3 0.93 9.3 1.0 2.3 1 1 1 2 2 2 0 Tho complex subunit THP2 G-alpha PF00503.15 ESA23793.1 - 0.068 11.8 3.2 0.092 11.4 2.2 1.1 1 0 0 1 1 1 0 G-protein alpha subunit ABC_tran_2 PF12848.2 ESA23793.1 - 0.075 12.8 8.2 0.14 12.0 5.7 1.5 1 0 0 1 1 1 0 ABC transporter Alb1 PF09135.6 ESA23793.1 - 0.12 13.0 7.2 0.24 12.0 5.0 1.5 1 0 0 1 1 1 0 Alb1 HD_assoc PF13286.1 ESA23793.1 - 0.17 12.1 1.1 9.3 6.5 0.1 2.4 1 1 1 2 2 2 0 Phosphohydrolase-associated domain OEP PF02321.13 ESA23793.1 - 0.18 11.4 3.1 0.35 10.4 2.1 1.4 1 0 0 1 1 1 0 Outer membrane efflux protein TMPIT PF07851.8 ESA23793.1 - 0.23 10.4 4.4 0.27 10.2 3.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein COG2 PF06148.6 ESA23793.1 - 0.28 11.0 4.6 0.65 9.8 3.0 1.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF342 PF03961.8 ESA23793.1 - 0.33 9.3 10.2 0.38 9.1 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) GAS PF13851.1 ESA23793.1 - 0.4 9.8 14.7 0.51 9.5 9.0 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding RPW8 PF05659.6 ESA23793.1 - 0.4 10.2 8.0 0.18 11.3 3.7 1.7 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Borrelia_P83 PF05262.6 ESA23793.1 - 0.44 8.7 6.9 0.43 8.7 4.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FliJ PF02050.11 ESA23793.1 - 0.47 10.5 11.1 0.92 9.5 7.7 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein DUF2951 PF11166.3 ESA23793.1 - 0.57 10.0 13.1 0.94 9.3 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) PEP-utilisers_N PF05524.8 ESA23793.1 - 0.7 9.6 3.1 1.1 9.0 1.9 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal FemAB PF02388.11 ESA23793.1 - 0.71 8.4 6.0 0.99 8.0 4.2 1.3 1 0 0 1 1 1 0 FemAB family Atg14 PF10186.4 ESA23793.1 - 0.79 8.6 9.0 0.95 8.3 6.3 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spectrin PF00435.16 ESA23793.1 - 0.87 9.9 8.1 0.97 9.7 5.0 1.6 1 1 0 1 1 1 0 Spectrin repeat FliS PF02561.9 ESA23793.1 - 0.97 9.3 4.7 4.9 7.0 3.2 2.1 1 1 0 1 1 1 0 Flagellar protein FliS DUF848 PF05852.6 ESA23793.1 - 1 9.2 8.3 0.67 9.7 4.7 1.4 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) zf-C4H2 PF10146.4 ESA23793.1 - 1.1 9.2 10.9 1.2 9.0 7.6 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Cgr1 PF03879.9 ESA23793.1 - 1.1 9.4 17.8 2.1 8.5 12.3 1.4 1 0 0 1 1 1 0 Cgr1 family DUF4200 PF13863.1 ESA23793.1 - 1.2 9.0 18.0 9.3 6.2 12.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) CCDC-167 PF15188.1 ESA23793.1 - 1.2 9.0 12.4 0.13 12.2 0.4 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 APG6 PF04111.7 ESA23793.1 - 1.3 8.0 8.5 1.5 7.7 5.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 ESA23793.1 - 1.8 6.3 6.3 2.1 6.1 4.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family XhlA PF10779.4 ESA23793.1 - 2.4 8.1 16.5 0.85 9.5 0.6 2.6 2 1 1 3 3 2 0 Haemolysin XhlA DUF4337 PF14235.1 ESA23793.1 - 3 7.6 6.0 4.5 7.0 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Lge1 PF11488.3 ESA23793.1 - 3.6 7.8 8.1 1.8 8.8 2.4 2.3 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Mgr1 PF08602.5 ESA23793.1 - 3.9 6.3 6.6 4.5 6.1 4.6 1.3 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DREPP PF05558.7 ESA23793.1 - 4.9 6.9 13.4 0.13 12.0 0.3 2.1 1 1 1 2 2 2 0 DREPP plasma membrane polypeptide UPF0147 PF03685.8 ESA23793.1 - 5.6 6.9 6.7 8.3 6.3 1.2 2.6 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0147) Mnd1 PF03962.10 ESA23793.1 - 6.2 6.4 11.7 4.1 7.0 6.9 1.5 1 1 1 2 2 2 0 Mnd1 family Sipho_Gp157 PF05565.6 ESA23793.1 - 6.4 6.3 14.9 2.4 7.7 3.3 2.8 1 1 1 2 2 2 0 Siphovirus Gp157 IncA PF04156.9 ESA23793.1 - 7.9 6.0 11.1 13 5.3 7.7 1.5 1 1 0 1 1 1 0 IncA protein FlaC_arch PF05377.6 ESA23793.1 - 8.3 6.3 7.3 8.8 6.3 1.4 3.2 2 1 1 3 3 2 0 Flagella accessory protein C (FlaC) DUF2992 PF11208.3 ESA23793.1 - 9.3 6.1 11.9 20 5.1 8.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) THOC7 PF05615.8 ESA23793.1 - 9.3 6.5 13.6 5 7.3 7.9 1.7 1 1 1 2 2 2 0 Tho complex subunit 7 HSP70 PF00012.15 ESA23794.1 - 0.0016 16.4 0.0 0.002 16.1 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Kinase-like PF14531.1 ESA23794.1 - 0.059 12.3 0.0 0.085 11.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Erythro_esteras PF05139.9 ESA23795.1 - 0.18 10.9 3.5 0.39 9.8 2.4 1.6 1 1 0 1 1 1 0 Erythromycin esterase HlyD PF00529.15 ESA23795.1 - 0.33 10.2 7.9 0.54 9.5 5.5 1.3 1 0 0 1 1 1 0 HlyD family secretion protein DUF749 PF05370.6 ESA23795.1 - 1.8 8.5 12.0 3.4 7.6 5.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF749) HSP70 PF00012.15 ESA23796.1 - 6.2e-07 27.7 0.0 2.2e-06 25.8 0.1 1.8 2 1 0 2 2 2 1 Hsp70 protein ADIP PF11559.3 ESA23798.1 - 0.012 15.5 24.8 0.12 12.2 9.0 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding IncA PF04156.9 ESA23798.1 - 0.028 14.0 27.1 0.93 9.0 11.2 2.9 1 1 1 2 2 2 0 IncA protein DUF904 PF06005.7 ESA23798.1 - 0.029 14.6 28.2 2.1 8.6 1.1 4.1 2 1 1 3 3 3 0 Protein of unknown function (DUF904) DUF4200 PF13863.1 ESA23798.1 - 0.093 12.6 29.6 15 5.5 12.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) WXG100 PF06013.7 ESA23798.1 - 0.45 10.5 6.1 12 5.9 0.2 4.0 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF948 PF06103.6 ESA23798.1 - 0.92 9.4 14.0 0.16 11.8 0.8 3.6 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 ESA23798.1 - 2.4 7.2 8.7 6 5.9 6.0 1.7 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Leu_zip PF15294.1 ESA23798.1 - 3.5 6.6 32.5 4.1 6.4 18.6 2.5 1 1 1 2 2 2 0 Leucine zipper Rootletin PF15035.1 ESA23798.1 - 4.5 7.2 35.7 0.068 13.1 5.6 3.5 3 1 1 4 4 4 0 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.2 ESA23798.1 - 8 6.3 35.0 4.3 7.1 15.2 3.6 2 1 1 3 3 3 0 Tropomyosin like Geminin PF07412.7 ESA23799.1 - 0.0087 15.7 3.4 0.0087 15.7 2.4 2.5 1 1 1 2 2 2 1 Geminin Lge1 PF11488.3 ESA23799.1 - 0.01 16.0 16.7 0.31 11.2 1.6 3.0 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 Cation_ATPase_N PF00690.21 ESA23799.1 - 0.018 14.4 0.4 0.25 10.8 0.0 2.7 3 0 0 3 3 3 0 Cation transporter/ATPase, N-terminus Synaptobrevin PF00957.16 ESA23799.1 - 0.1 12.2 9.5 1.6 8.3 0.2 2.6 1 1 1 2 2 2 0 Synaptobrevin FTA4 PF13093.1 ESA23799.1 - 0.13 11.7 20.1 0.61 9.4 0.5 3.1 1 1 1 3 3 3 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 tRNA_bind_2 PF13725.1 ESA23799.1 - 0.13 12.4 0.4 0.29 11.2 0.1 1.6 1 1 0 1 1 1 0 Possible tRNA binding domain DUF3223 PF11523.3 ESA23799.1 - 0.17 12.2 1.7 0.24 11.7 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3223) Bap31 PF05529.7 ESA23799.1 - 0.28 10.6 23.8 0.29 10.5 4.9 2.7 2 1 1 3 3 3 0 B-cell receptor-associated protein 31-like Tup_N PF08581.5 ESA23799.1 - 0.8 9.9 14.0 1.7 8.8 6.5 3.0 1 1 1 2 2 2 0 Tup N-terminal DUF342 PF03961.8 ESA23799.1 - 1.8 6.9 17.1 0.37 9.1 8.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Med22 PF06179.7 ESA23799.1 - 2.2 8.3 13.9 0.76 9.8 1.1 3.7 2 1 2 4 4 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex DUF1154 PF06631.6 ESA23799.1 - 2.4 7.8 12.5 1.3 8.7 2.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) PRP1_N PF06424.7 ESA23799.1 - 2.8 8.2 15.2 2.9 8.2 9.4 1.9 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal HSP70 PF00012.15 ESA23800.1 - 0.0041 15.1 0.0 0.061 11.2 0.0 2.4 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 ESA23800.1 - 0.0058 15.2 0.0 0.12 10.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DUF443 PF04276.7 ESA23800.1 - 0.057 12.8 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF443) DUF1730 PF08331.5 ESA23801.1 - 0.05 13.2 0.0 0.35 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1730) BTB PF00651.26 ESA23802.1 - 1.7e-17 63.3 1.7 3.5e-17 62.4 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain TLD PF07534.11 ESA23802.1 - 4.4e-12 46.1 4.4 4.2e-11 42.9 0.7 3.0 3 0 0 3 3 3 1 TLD BACK PF07707.10 ESA23802.1 - 1.2e-05 25.1 2.5 3.7e-05 23.5 1.2 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch Terpene_synth_C PF03936.11 ESA23803.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.4 1 1 0 1 1 1 0 Terpene synthase family, metal binding domain HSP70 PF00012.15 ESA23805.1 - 9.8e-11 40.2 0.2 1.9e-05 22.8 0.0 3.3 3 1 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.8 ESA23805.1 - 2.8e-08 32.7 0.0 0.00036 19.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Peptidase_M22 PF00814.20 ESA23805.1 - 0.024 14.1 0.0 0.23 10.9 0.0 2.0 1 1 0 1 1 1 0 Glycoprotease family SRA1 PF07304.6 ESA23806.1 - 0.035 13.8 0.5 0.066 12.9 0.3 1.4 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) DUF4047 PF13256.1 ESA23809.1 - 0.05 13.5 0.5 5.5 6.9 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) TLD PF07534.11 ESA23811.1 - 1.8e-15 57.1 0.7 4.4e-15 55.8 0.5 1.7 1 1 0 1 1 1 1 TLD BTB PF00651.26 ESA23811.1 - 1.3e-14 54.0 1.6 1.6e-14 53.7 0.2 1.8 2 0 0 2 2 2 1 BTB/POZ domain DUF285 PF03382.9 ESA23811.1 - 0.0025 17.3 0.0 0.0072 15.8 0.0 1.7 1 0 0 1 1 1 1 Mycoplasma protein of unknown function, DUF285 BACK PF07707.10 ESA23811.1 - 0.17 11.7 4.0 0.49 10.2 1.1 2.7 2 1 1 3 3 3 0 BTB And C-terminal Kelch BTB PF00651.26 ESA23812.1 - 1.9e-19 69.6 0.5 5.9e-19 68.0 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain TLD PF07534.11 ESA23812.1 - 1.1e-13 51.3 1.8 2.6e-13 50.1 1.3 1.7 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA23812.1 - 0.0034 17.1 0.8 0.13 12.0 0.3 3.0 2 1 1 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.26 ESA23813.1 - 4.7e-17 61.9 0.5 1e-16 60.9 0.3 1.6 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA23813.1 - 5.4e-13 49.1 0.5 1.5e-12 47.7 0.4 1.8 1 0 0 1 1 1 1 TLD BACK PF07707.10 ESA23813.1 - 0.00065 19.5 3.7 0.0032 17.2 1.1 2.9 2 1 1 3 3 3 1 BTB And C-terminal Kelch DUF241 PF03087.9 ESA23814.1 - 0.0012 18.3 2.7 0.0023 17.4 1.9 1.5 1 1 0 1 1 1 1 Arabidopsis protein of unknown function Tropomyosin PF00261.15 ESA23814.1 - 0.56 9.2 7.6 0.46 9.5 4.2 1.6 1 1 0 1 1 1 0 Tropomyosin zf-C3HC PF07967.8 ESA23814.1 - 1.1 8.9 5.2 1.2 8.8 1.6 2.5 2 1 0 2 2 2 0 C3HC zinc finger-like Troponin PF00992.15 ESA23814.1 - 1.5 8.8 5.0 5.8 6.9 2.8 2.2 2 0 0 2 2 2 0 Troponin DUF603 PF04645.7 ESA23814.1 - 4.4 7.2 12.1 7 6.5 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF603 Exo_endo_phos_2 PF14529.1 ESA23816.1 - 1.4e-06 27.8 1.0 3.5e-06 26.6 0.7 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA23816.1 - 0.0019 18.1 0.0 0.0022 17.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NYD-SP28 PF14772.1 ESA23816.1 - 0.071 13.2 0.4 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Sperm tail Pkinase_Tyr PF07714.12 ESA23818.1 - 1.6e-34 119.1 0.0 2.9e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23818.1 - 3.1e-33 115.0 0.1 3.1e-33 115.0 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.9 ESA23818.1 - 0.0044 16.1 0.0 0.0076 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MMR_HSR1 PF01926.18 ESA23819.1 - 3e-08 33.6 0.4 1.3e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.11 ESA23819.1 - 2.5e-05 23.5 0.2 0.023 13.8 0.0 3.2 3 0 0 3 3 3 2 AIG1 family DUF258 PF03193.11 ESA23819.1 - 0.00014 21.1 0.0 0.00073 18.7 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 ESA23819.1 - 0.001 18.5 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 ESA23819.1 - 0.0048 15.8 0.0 0.0097 14.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein GTP_EFTU PF00009.22 ESA23819.1 - 0.0068 15.8 0.4 0.017 14.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.24 ESA23819.1 - 0.0093 16.1 0.2 2.3 8.3 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 ESA23819.1 - 0.012 15.0 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.22 ESA23819.1 - 0.019 15.2 0.1 0.28 11.4 0.0 2.9 2 0 0 2 2 2 0 ABC transporter Miro PF08477.8 ESA23819.1 - 0.019 15.4 0.0 0.092 13.2 0.0 2.3 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 ESA23819.1 - 0.031 14.2 0.0 0.12 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.21 ESA23819.1 - 0.044 13.2 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.1 ESA23819.1 - 0.089 12.9 0.0 0.38 10.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain Ras PF00071.17 ESA23819.1 - 0.11 11.8 3.5 1 8.7 0.0 3.4 3 0 0 3 3 3 0 Ras family Dynamin_N PF00350.18 ESA23819.1 - 0.35 10.6 9.0 3.6 7.3 0.1 4.1 4 0 0 4 4 4 0 Dynamin family Retrotrans_gag PF03732.12 ESA23819.1 - 4.3 7.4 5.4 53 3.9 1.6 3.1 2 1 1 3 3 2 0 Retrotransposon gag protein Pkinase_Tyr PF07714.12 ESA23820.1 - 6.7e-16 58.1 0.0 1.5e-08 34.0 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Pkinase PF00069.20 ESA23820.1 - 2.6e-10 39.8 5.2 3.2e-07 29.7 0.0 3.5 3 1 0 3 3 3 2 Protein kinase domain BCS1_N PF08740.6 ESA23820.1 - 0.0022 17.6 0.1 1.9 8.0 0.0 2.6 2 0 0 2 2 2 2 BCS1 N terminal PTH2 PF01981.11 ESA23820.1 - 0.019 14.6 0.3 9.4 5.9 0.0 3.0 3 0 0 3 3 3 0 Peptidyl-tRNA hydrolase PTH2 Cas_Csa5 PF09702.5 ESA23820.1 - 0.14 12.2 4.4 14 5.7 0.1 4.4 5 1 0 5 5 5 0 CRISPR-associated protein (Cas_Csa5) DUF3267 PF11667.3 ESA23821.1 - 0.036 14.2 1.1 0.053 13.7 0.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3267) Syntaphilin PF15290.1 ESA23822.1 - 0.0066 15.9 2.5 0.0066 15.9 1.7 1.8 2 0 0 2 2 2 1 Golgi-localised syntaxin-1-binding clamp BTB PF00651.26 ESA23823.1 - 4.1e-19 68.6 0.0 7.9e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain TLD PF07534.11 ESA23823.1 - 1.9e-10 40.8 3.6 9.2e-10 38.6 1.5 2.6 2 1 0 2 2 2 1 TLD BACK PF07707.10 ESA23823.1 - 0.00017 21.3 3.4 0.00052 19.8 0.6 2.7 1 1 2 3 3 3 1 BTB And C-terminal Kelch DUF1796 PF08795.5 ESA23825.1 - 0.031 13.8 0.6 0.044 13.4 0.5 1.4 1 1 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) MreB_Mbl PF06723.8 ESA23826.1 - 0.027 13.0 0.0 0.039 12.5 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein PocR PF10114.4 ESA23826.1 - 0.053 12.6 0.1 0.31 10.1 0.0 2.0 1 1 0 2 2 2 0 Sensory domain found in PocR HSP70 PF00012.15 ESA23827.1 - 0.021 12.7 0.0 0.025 12.5 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF2654 PF10849.3 ESA23829.1 - 0.069 12.8 0.1 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2654) zf-BED PF02892.10 ESA23831.1 - 0.012 15.3 1.9 0.03 14.0 1.3 1.7 1 1 0 1 1 1 0 BED zinc finger RAMPs PF03787.10 ESA23831.1 - 0.088 12.6 0.5 0.11 12.2 0.4 1.2 1 0 0 1 1 1 0 RAMP superfamily FAM92 PF06730.6 ESA23832.1 - 0.018 14.3 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 FAM92 protein Cu-oxidase_3 PF07732.10 ESA23833.1 - 6.4e-33 112.9 0.0 7.6e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 ESA23833.1 - 0.055 12.9 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Multicopper oxidase Cupredoxin_1 PF13473.1 ESA23833.1 - 0.12 12.2 0.1 0.39 10.6 0.1 2.1 1 1 0 1 1 1 0 Cupredoxin-like domain AAA_13 PF13166.1 ESA23834.1 - 0.016 13.7 13.2 0.02 13.3 9.2 1.1 1 0 0 1 1 1 0 AAA domain TRAPPC-Trs85 PF12739.2 ESA23834.1 - 0.069 11.7 1.0 0.088 11.4 0.7 1.1 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit PhosphMutase PF10143.4 ESA23834.1 - 0.099 12.2 1.3 0.17 11.5 0.9 1.3 1 0 0 1 1 1 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Vfa1 PF08432.5 ESA23834.1 - 0.16 11.9 12.3 0.23 11.4 8.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sugarporin_N PF11471.3 ESA23834.1 - 0.64 9.7 12.0 1.7 8.3 0.6 2.9 2 1 0 2 2 2 0 Maltoporin periplasmic N-terminal extension HSP70 PF00012.15 ESA23834.1 - 2.7 5.8 13.2 3.4 5.4 9.2 1.1 1 0 0 1 1 1 0 Hsp70 protein Coiled-coil_56 PF09813.4 ESA23834.1 - 4.6 7.2 9.9 2.1 8.3 0.4 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 56 Flu_NS2 PF00601.14 ESA23834.1 - 8.6 6.6 10.8 0.36 11.0 0.2 2.7 2 1 0 3 3 3 0 Influenza non-structural protein (NS2) Tom37_C PF11801.3 ESA23834.1 - 9.2 6.0 11.5 15 5.4 8.0 1.3 1 0 0 1 1 1 0 Tom37 C-terminal domain VWA_2 PF13519.1 ESA23835.1 - 1.1e-12 48.4 0.0 2.2e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain GBP PF02263.14 ESA23836.1 - 2.6e-41 141.3 0.0 2.6e-41 141.3 0.0 2.9 3 2 0 3 3 3 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 ESA23836.1 - 1.1e-10 41.1 34.9 1.1e-10 41.1 24.2 2.9 1 1 1 2 2 2 1 Guanylate-binding protein, C-terminal domain zf-LYAR PF08790.6 ESA23836.1 - 0.049 13.3 0.3 0.11 12.1 0.2 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger PLD_C PF12357.3 ESA23836.1 - 0.09 12.3 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 Phospholipase D C terminal Amidase PF01425.16 ESA23836.1 - 1.1 8.0 0.0 1.1 8.0 0.0 3.0 2 1 1 3 3 3 0 Amidase DUF1509 PF07420.6 ESA23837.1 - 0.0032 16.8 0.8 0.0032 16.8 0.6 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1509) BRCA-2_helical PF09169.5 ESA23837.1 - 0.0083 15.7 0.3 0.0083 15.7 0.2 1.9 2 0 0 2 2 2 1 BRCA2, helical Mucin PF01456.12 ESA23837.1 - 0.061 13.1 16.4 0.11 12.2 11.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.3 ESA23837.1 - 0.12 12.1 10.9 0.23 11.2 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.6 ESA23837.1 - 1.4 6.8 12.9 2.3 6.1 9.0 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Cullin PF00888.17 ESA23839.1 - 2e-116 389.9 7.9 2.2e-116 389.7 5.5 1.0 1 0 0 1 1 1 1 Cullin family Cullin PF00888.17 ESA23841.1 - 1.1e-182 608.6 7.4 1.4e-182 608.3 5.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 ESA23841.1 - 1.7e-28 98.2 2.6 1.7e-28 98.2 1.8 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain Birna_VP3 PF01767.11 ESA23841.1 - 0.0044 16.6 0.8 0.011 15.3 0.6 1.6 1 0 0 1 1 1 1 Birnavirus VP3 protein UcrQ PF02939.11 ESA23842.1 - 3.4e-28 97.2 0.5 3.7e-28 97.1 0.3 1.0 1 0 0 1 1 1 1 UcrQ family YqfQ PF14181.1 ESA23843.1 - 0.13 12.3 7.6 0.12 12.3 5.3 1.1 1 0 0 1 1 1 0 YqfQ-like protein GAGA_bind PF06217.7 ESA23843.1 - 0.18 11.7 6.6 0.21 11.5 4.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family FLO_LFY PF01698.11 ESA23843.1 - 0.26 10.0 5.9 0.28 9.9 4.1 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein NARP1 PF12569.3 ESA23843.1 - 0.33 9.6 11.8 0.38 9.4 8.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rtf2 PF04641.7 ESA23843.1 - 0.36 10.0 10.4 0.4 9.8 7.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Peptidase_S49_N PF08496.5 ESA23843.1 - 0.46 10.2 9.4 0.56 10.0 6.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Hph PF13694.1 ESA23843.1 - 1.1 9.2 11.5 1.4 8.9 8.0 1.1 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family PDCD2_C PF04194.8 ESA23843.1 - 2.6 7.6 6.8 3.7 7.1 4.7 1.4 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Presenilin PF01080.12 ESA23843.1 - 3.9 6.2 4.8 4.2 6.0 3.3 1.0 1 0 0 1 1 1 0 Presenilin Mem_trans PF03547.13 ESA23843.1 - 4.7 5.4 5.7 5.3 5.2 3.9 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF3573 PF12097.3 ESA23843.1 - 4.7 5.7 8.7 5.3 5.5 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CDC45 PF02724.9 ESA23843.1 - 5 5.0 8.2 5.8 4.8 5.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 ESA23843.1 - 5.8 6.2 20.2 7.5 5.8 14.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Sec62 PF03839.11 ESA23843.1 - 6.8 6.0 10.5 8 5.8 7.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RNA_polI_A34 PF08208.6 ESA23843.1 - 8.7 5.9 17.7 11 5.5 12.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DEAD PF00270.24 ESA23844.1 - 4.5e-17 62.0 0.1 7.1e-17 61.4 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 ESA23844.1 - 0.0033 17.2 0.0 0.0033 17.2 0.0 3.1 1 1 1 3 3 3 1 Type III restriction enzyme, res subunit MIP-T3 PF10243.4 ESA23844.1 - 0.86 7.9 30.7 1.2 7.5 21.3 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 LON PF02190.11 ESA23846.1 - 3.8e-19 69.1 0.0 1e-18 67.8 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain F-box-like PF12937.2 ESA23846.1 - 8.9e-06 25.3 0.0 2.4e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 F-box-like zf-C3HC4_2 PF13923.1 ESA23846.1 - 9.8e-05 22.3 14.6 0.00028 20.8 10.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23846.1 - 0.00015 21.3 12.1 0.0004 19.9 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA23846.1 - 0.00065 19.3 10.8 0.0013 18.4 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Arch_fla_DE PF04659.8 ESA23846.1 - 0.071 12.9 0.5 0.24 11.2 0.4 1.9 1 0 0 1 1 1 0 Archaeal flagella protein zf-RING_2 PF13639.1 ESA23846.1 - 0.15 11.8 18.7 0.019 14.8 9.5 2.2 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.1 ESA23846.1 - 0.17 11.8 11.5 0.54 10.1 8.0 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 ESA23846.1 - 0.23 11.2 7.5 0.57 9.9 5.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.1 ESA23846.1 - 0.46 10.2 18.9 0.057 13.1 9.8 2.1 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.1 ESA23846.1 - 7.1 6.2 13.2 0.8 9.2 5.0 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF659 PF04937.10 ESA23847.1 - 1e-13 51.0 0.0 1.5e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) zf-BED PF02892.10 ESA23847.1 - 3.1e-06 26.8 2.4 3.1e-06 26.8 1.7 2.3 2 0 0 2 2 2 1 BED zinc finger Dimer_Tnp_hAT PF05699.9 ESA23848.1 - 0.0097 15.5 0.4 0.034 13.7 0.0 2.0 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region zf-BED PF02892.10 ESA23848.1 - 0.033 13.9 3.6 0.072 12.8 2.5 1.6 1 0 0 1 1 1 0 BED zinc finger BUD22 PF09073.5 ESA23848.1 - 0.15 11.0 2.7 0.082 11.9 0.4 1.5 2 0 0 2 2 2 0 BUD22 CEP19 PF14933.1 ESA23849.1 - 0.21 11.9 3.3 0.45 10.7 1.5 2.0 1 1 1 2 2 2 0 CEP19-like protein MIR PF02815.14 ESA23850.1 - 0.013 15.0 3.7 0.57 9.6 0.0 2.9 1 1 1 2 2 2 0 MIR domain DUF972 PF06156.8 ESA23851.1 - 0.0077 16.5 0.4 0.0077 16.5 0.2 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF972) Occludin_ELL PF07303.8 ESA23851.1 - 0.21 12.3 0.1 0.21 12.3 0.1 2.2 2 0 0 2 2 2 0 Occludin homology domain ATG16 PF08614.6 ESA23851.1 - 0.63 9.8 16.5 0.31 10.8 0.8 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF966 PF06136.8 ESA23851.1 - 1 8.7 13.3 1.2 8.4 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TMCO5 PF14992.1 ESA23851.1 - 2.9 6.9 9.9 0.085 11.9 0.5 2.0 2 0 0 2 2 2 0 TMCO5 family ADIP PF11559.3 ESA23851.1 - 6.4 6.6 17.1 2.5 7.9 0.4 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding AUX_IAA PF02309.11 ESA23851.1 - 7 6.3 10.6 10 5.8 7.3 1.3 1 0 0 1 1 1 0 AUX/IAA family Presenilin PF01080.12 ESA23851.1 - 9.5 4.9 7.7 11 4.7 5.3 1.2 1 0 0 1 1 1 0 Presenilin RNA_Me_trans PF04252.8 ESA23852.1 - 0.0036 16.7 0.1 0.016 14.6 0.1 1.8 1 1 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Mer2 PF09074.5 ESA23852.1 - 0.036 14.0 1.0 0.044 13.7 0.7 1.1 1 0 0 1 1 1 0 Mer2 DUF1617 PF07761.7 ESA23853.1 - 0.0038 17.2 0.4 0.0045 17.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1617) RNA_Me_trans PF04252.8 ESA23853.1 - 0.072 12.4 0.0 0.086 12.2 0.0 1.3 1 1 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase F-box-like PF12937.2 ESA23854.1 - 7.2e-07 28.8 0.2 2.9e-06 26.8 0.1 2.0 1 0 0 1 1 1 1 F-box-like NAD_binding_10 PF13460.1 ESA23857.1 - 2.5e-17 63.4 0.0 3.2e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 ESA23857.1 - 6.4e-06 25.5 0.0 1.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 ESA23857.1 - 1e-05 25.0 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 ESA23857.1 - 0.00047 18.9 0.0 0.00066 18.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Ldh_1_N PF00056.18 ESA23857.1 - 0.0063 16.3 0.0 0.0091 15.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 ESA23857.1 - 0.021 13.8 0.0 0.029 13.3 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase Semialdhyde_dh PF01118.19 ESA23857.1 - 0.096 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DnaB PF00772.16 ESA23857.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain adh_short PF00106.20 ESA23857.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase F-box-like PF12937.2 ESA23858.1 - 0.00086 18.9 1.1 0.0016 18.1 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 ESA23858.1 - 0.11 12.2 3.8 1 9.0 0.1 3.7 3 0 0 3 3 3 0 F-box domain LRR_4 PF12799.2 ESA23858.1 - 0.6 9.8 18.6 1.2 8.8 2.8 4.0 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 ESA23858.1 - 9.7 6.6 19.6 22 5.5 0.3 6.0 5 1 1 6 6 6 0 Leucine Rich repeat DFF40 PF09230.5 ESA23860.1 - 0.0012 18.2 0.4 2.9 7.1 0.0 3.4 1 1 0 3 3 3 2 DNA fragmentation factor 40 kDa DUF3782 PF12644.2 ESA23860.1 - 0.0012 18.5 0.1 1.1 9.0 0.0 3.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3782) DUF2340 PF10209.4 ESA23860.1 - 0.0036 17.4 14.5 0.31 11.2 1.5 3.4 1 1 2 3 3 3 2 Uncharacterized conserved protein (DUF2340) AAT PF03417.11 ESA23860.1 - 0.025 14.0 3.4 1.4 8.2 0.7 2.2 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Sof1 PF04158.9 ESA23860.1 - 0.11 12.5 10.5 1.4 8.9 0.3 3.5 4 0 0 4 4 4 0 Sof1-like domain Peptidase_C15 PF01470.12 ESA23860.1 - 0.57 9.9 6.7 6.4 6.5 0.2 3.4 3 0 0 3 3 3 0 Pyroglutamyl peptidase Glutaredoxin2_C PF04399.8 ESA23860.1 - 0.66 9.5 13.7 3.8 7.1 0.5 3.3 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain Peptidase_U57 PF05582.7 ESA23860.1 - 1.3 7.9 9.3 0.53 9.2 4.2 1.8 1 1 1 2 2 2 0 YabG peptidase U57 Pentapeptide_3 PF13576.1 ESA23861.1 - 0.021 14.6 0.5 0.021 14.6 0.3 1.9 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) CHASE3 PF05227.8 ESA23862.1 - 0.00091 18.9 4.0 0.0067 16.1 1.3 2.3 1 1 1 2 2 2 1 CHASE3 domain DUF972 PF06156.8 ESA23862.1 - 0.16 12.3 18.2 0.37 11.1 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) LOH1CR12 PF10158.4 ESA23862.1 - 0.16 11.7 5.2 1.8 8.3 0.4 2.2 2 0 0 2 2 2 0 Tumour suppressor protein TPR_MLP1_2 PF07926.7 ESA23862.1 - 0.36 10.5 22.5 0.54 9.9 3.0 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF904 PF06005.7 ESA23862.1 - 0.38 11.0 30.9 0.34 11.2 2.7 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF904) DUF1319 PF07028.6 ESA23862.1 - 0.4 10.8 13.3 2 8.6 1.5 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) ICAT PF06384.6 ESA23862.1 - 0.41 10.4 8.1 0.059 13.1 1.0 2.4 2 1 0 2 2 2 0 Beta-catenin-interacting protein ICAT DUF2748 PF10871.3 ESA23862.1 - 0.47 8.8 6.5 0.28 9.5 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2748) CRA PF06589.6 ESA23862.1 - 0.55 9.5 12.5 0.41 9.9 2.4 2.4 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) DUF1798 PF08807.5 ESA23862.1 - 0.55 9.9 13.0 0.18 11.4 0.8 2.7 2 1 1 3 3 3 0 Bacterial domain of unknown function (DUF1798) Cep57_MT_bd PF06657.8 ESA23862.1 - 0.61 10.0 12.5 2 8.4 0.9 3.0 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 APG6 PF04111.7 ESA23862.1 - 1.4 7.8 26.3 0.46 9.4 2.7 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 IncA PF04156.9 ESA23862.1 - 1.9 8.0 22.7 5.5e+03 -3.3 15.7 2.1 1 1 0 1 1 1 0 IncA protein AAA_13 PF13166.1 ESA23862.1 - 2.4 6.5 24.2 6.1 5.1 16.8 1.5 1 1 0 1 1 1 0 AAA domain Prominin PF05478.6 ESA23862.1 - 2.6 5.4 11.1 4.5 4.6 7.7 1.4 1 1 0 1 1 1 0 Prominin Uds1 PF15456.1 ESA23862.1 - 3 7.8 17.4 8.2e+02 -0.1 12.0 2.3 1 1 0 1 1 1 0 Up-regulated During Septation FadA PF09403.5 ESA23862.1 - 3.2 7.7 25.1 0.51 10.3 5.9 3.0 1 1 2 3 3 3 0 Adhesion protein FadA Baculo_p24 PF05073.7 ESA23862.1 - 3.7 7.0 10.1 28 4.2 6.8 2.1 1 1 0 1 1 1 0 Baculovirus P24 capsid protein ACCA PF03255.9 ESA23862.1 - 6.7 6.2 16.6 2.9 7.4 1.4 2.3 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TMF_TATA_bd PF12325.3 ESA23862.1 - 8 6.2 19.4 4.1 7.1 0.4 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding B3 PF02362.16 ESA23863.1 - 0.071 12.7 0.0 0.37 10.4 0.0 2.2 2 0 0 2 2 2 0 B3 DNA binding domain WD40 PF00400.27 ESA23864.1 - 0.19 11.6 1.0 0.35 10.8 0.7 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat ThiF PF00899.16 ESA23865.1 - 1.4e-39 135.0 0.3 2.4e-39 134.2 0.2 1.4 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 ESA23865.1 - 1.8e-27 94.7 0.1 3.3e-27 93.9 0.1 1.4 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 ESA23865.1 - 1.1e-11 45.1 0.0 5.1e-11 42.9 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.15 ESA23865.1 - 0.0085 16.1 5.0 0.01 15.9 0.7 2.8 3 1 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 ESA23865.1 - 0.02 15.1 0.1 0.059 13.6 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.14 ESA23865.1 - 0.043 12.8 0.1 0.062 12.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Saccharop_dh PF03435.13 ESA23865.1 - 0.1 11.5 0.3 0.16 10.8 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase ApbA PF02558.11 ESA23865.1 - 0.11 11.9 0.1 0.2 11.0 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FH2 PF02181.18 ESA23866.1 - 4.1e-61 206.9 4.6 5e-61 206.6 3.2 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain DNA_pack_N PF02500.10 ESA23866.1 - 0.066 12.7 0.2 0.081 12.4 0.1 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus His_kinase PF06580.8 ESA23866.1 - 0.07 13.0 3.6 4.7 7.1 0.1 3.0 3 0 0 3 3 3 0 Histidine kinase RRM_1 PF00076.17 ESA23867.1 - 1.3e-56 188.1 7.9 1.9e-18 65.8 0.1 4.9 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA23867.1 - 1.3e-40 137.2 2.9 1.2e-13 50.7 0.0 5.1 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA23867.1 - 1.4e-24 85.6 6.1 8.3e-08 31.9 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA23867.1 - 0.0019 17.9 2.5 2.1 8.1 0.0 4.4 5 0 0 5 5 5 2 Nup53/35/40-type RNA recognition motif TPR_14 PF13428.1 ESA23867.1 - 0.017 15.7 0.0 2.4 9.0 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat PdxJ PF03740.8 ESA23868.1 - 0.068 12.3 0.3 0.082 12.0 0.2 1.1 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ DltD_C PF04914.7 ESA23870.1 - 0.049 13.4 0.4 0.12 12.1 0.3 1.6 1 0 0 1 1 1 0 DltD C-terminal region PrgU PF09627.5 ESA23871.1 - 0.078 12.5 0.7 7.2 6.2 0.1 2.2 2 0 0 2 2 2 0 PrgU-like protein KRTDAP PF15200.1 ESA23874.1 - 0.12 12.1 1.3 0.15 11.8 0.1 1.7 1 1 1 2 2 2 0 Keratinocyte differentiation-associated IZUMO PF15005.1 ESA23875.1 - 0.0084 16.1 0.3 0.0087 16.1 0.2 1.0 1 0 0 1 1 1 1 Izumo sperm-egg fusion PIF1 PF05970.9 ESA23876.1 - 1.4e-05 24.2 0.0 1.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.1 ESA23876.1 - 0.0036 17.0 0.0 0.0047 16.6 0.0 1.2 1 0 0 1 1 1 1 Part of AAA domain Herpes_Helicase PF02689.9 ESA23876.1 - 0.013 13.2 0.0 0.015 13.0 0.0 1.1 1 0 0 1 1 1 0 Helicase AAA_30 PF13604.1 ESA23876.1 - 0.024 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 ESA23876.1 - 0.04 13.1 0.0 0.14 11.3 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function, DUF258 Torsin PF06309.6 ESA23876.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Torsin Laminin_G_3 PF13385.1 ESA23877.1 - 3.3e-16 59.9 0.1 9e-16 58.5 0.0 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily PQQ PF01011.16 ESA23879.1 - 0.056 12.9 0.1 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 PQQ enzyme repeat Pkinase PF00069.20 ESA23883.1 - 3e-11 42.9 0.3 4e-11 42.5 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23883.1 - 8.8e-06 24.9 0.1 1.2e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.11 ESA23883.1 - 0.085 12.8 0.3 0.58 10.1 0.0 1.9 2 0 0 2 2 2 0 ABC1 family YTH PF04146.10 ESA23883.1 - 0.12 12.0 0.1 0.14 11.7 0.0 1.3 1 1 0 1 1 1 0 YT521-B-like domain MOZ_SAS PF01853.13 ESA23884.1 - 2.7e-77 258.2 0.7 3.4e-77 257.9 0.5 1.1 1 0 0 1 1 1 1 MOZ/SAS family DUF1002 PF06207.6 ESA23886.1 - 0.15 11.3 4.0 0.27 10.5 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Pox_Ag35 PF03286.9 ESA23886.1 - 1 8.8 5.3 1.4 8.3 3.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pox_Ag35 PF03286.9 ESA23887.1 - 0.23 10.9 2.7 0.29 10.6 1.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ocular_alb PF02101.10 ESA23889.1 - 0.069 11.7 0.3 0.074 11.6 0.2 1.0 1 0 0 1 1 1 0 Ocular albinism type 1 protein AAA_35 PF14516.1 ESA23892.1 - 3.6e-05 22.5 0.0 0.026 13.1 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain SieB PF14163.1 ESA23892.1 - 0.00073 19.1 0.7 2 7.9 0.0 3.3 3 0 0 3 3 3 2 Superinfection exclusion protein B AAA PF00004.24 ESA23892.1 - 0.005 17.0 0.1 0.026 14.7 0.0 2.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 ESA23892.1 - 0.088 13.6 0.2 0.46 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain BCS1_N PF08740.6 ESA23893.1 - 0.00016 21.3 4.2 0.28 10.7 0.1 4.3 5 0 0 5 5 5 2 BCS1 N terminal DUF4413 PF14372.1 ESA23893.1 - 0.0064 16.4 15.8 25 4.9 0.0 7.0 6 0 0 6 6 6 3 Domain of unknown function (DUF4413) 2Fe-2S_thioredx PF01257.14 ESA23894.1 - 6.1e-60 201.0 0.0 7.6e-60 200.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin GHMP_kinases_N PF00288.21 ESA23895.1 - 5e-11 42.5 0.0 1.4e-10 41.0 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 ESA23895.1 - 0.0015 18.6 0.0 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal MAPKK1_Int PF08923.5 ESA23896.1 - 1.2e-30 105.5 0.3 1.4e-30 105.3 0.2 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting Proteasome PF00227.21 ESA23897.1 - 6.2e-43 146.2 0.0 7.1e-43 146.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Prefoldin_2 PF01920.15 ESA23898.1 - 1.1e-07 31.5 6.2 1.3e-07 31.2 4.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit GntR PF00392.16 ESA23898.1 - 0.019 14.3 0.5 0.047 13.1 0.1 1.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Siah-Interact_N PF09032.6 ESA23898.1 - 0.037 14.0 0.2 0.037 14.0 0.2 1.9 2 1 0 2 2 2 0 Siah interacting protein, N terminal Prefoldin PF02996.12 ESA23898.1 - 0.056 13.0 4.0 0.11 12.1 2.8 1.6 1 1 0 1 1 1 0 Prefoldin subunit FUN14 PF04930.10 ESA23898.1 - 0.083 13.1 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 FUN14 family Mad3_BUB1_I PF08311.7 ESA23899.1 - 8.1e-38 129.0 0.6 2.1e-37 127.6 0.4 1.8 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.20 ESA23899.1 - 6.4e-24 84.4 0.0 1.4e-23 83.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23899.1 - 2.3e-12 46.5 0.0 4.3e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1825 PF08855.5 ESA23899.1 - 0.019 14.9 0.2 0.23 11.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) zf-U1 PF06220.7 ESA23900.1 - 4e-11 42.2 1.3 7.7e-11 41.3 0.9 1.5 1 0 0 1 1 1 1 U1 zinc finger Dscam_C PF12355.3 ESA23900.1 - 0.0028 17.9 0.6 0.0046 17.2 0.4 1.5 1 0 0 1 1 1 1 Down syndrome cell adhesion molecule C terminal CCDC84 PF14968.1 ESA23900.1 - 0.0056 16.2 2.1 0.0074 15.8 1.2 1.3 1 1 0 1 1 1 1 Coiled coil protein 84 DUF3513 PF12026.3 ESA23900.1 - 0.087 12.3 1.0 0.18 11.3 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3513) Amidase_3 PF01520.13 ESA23901.1 - 0.085 12.6 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase Cnd2 PF05786.9 ESA23902.1 - 1.5e-116 390.7 7.5 2.1e-116 390.2 5.2 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 Cnd2 PF05786.9 ESA23903.1 - 0.00055 18.6 0.0 0.00058 18.5 0.0 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Cnd2 PF05786.9 ESA23904.1 - 1.4e-21 76.7 0.8 1.6e-21 76.5 0.5 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 Prenyltrans PF00432.16 ESA23905.1 - 7.9e-42 140.4 2.8 5.9e-10 38.5 0.2 4.2 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 ESA23905.1 - 2.3e-28 98.8 0.1 6.2e-19 68.4 0.1 3.0 1 1 2 3 3 3 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 ESA23905.1 - 2.3e-08 33.9 0.0 0.0017 18.3 0.0 2.4 1 1 2 3 3 3 3 Prenyltransferase-like HEAT_PBS PF03130.11 ESA23905.1 - 0.027 14.9 0.6 0.087 13.3 0.0 2.1 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat BTB PF00651.26 ESA23907.1 - 1.7e-18 66.6 0.1 3.1e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA23907.1 - 5.5e-06 26.1 0.1 3.4e-05 23.6 0.0 2.5 1 1 0 1 1 1 1 BTB And C-terminal Kelch Pkinase PF00069.20 ESA23908.1 - 1.6e-18 66.7 1.0 3e-18 65.9 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23908.1 - 2e-18 66.3 0.0 3.8e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Zn_Tnp_IS91 PF14319.1 ESA23908.1 - 0.013 14.9 1.1 0.013 14.9 0.7 3.9 2 1 2 4 4 4 0 Transposase zinc-binding domain YchF-GTPase_C PF06071.8 ESA23908.1 - 0.041 13.6 0.1 0.16 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF933) Abhydrolase_6 PF12697.2 ESA23910.1 - 1.5e-25 90.4 0.0 1.8e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 ESA23910.1 - 1e-05 25.3 0.0 2.1e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 ESA23910.1 - 5e-05 22.9 0.0 0.0014 18.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.9 ESA23910.1 - 0.0015 17.0 0.0 0.16 10.4 0.0 2.1 2 0 0 2 2 2 2 Ndr family Esterase PF00756.15 ESA23910.1 - 0.0033 16.8 0.0 0.0049 16.3 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 ESA23910.1 - 0.035 13.3 0.0 0.067 12.4 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family PAF-AH_p_II PF03403.8 ESA23910.1 - 0.056 11.7 0.0 0.083 11.1 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II adh_short PF00106.20 ESA23911.1 - 3e-20 72.7 0.0 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA23911.1 - 1e-07 31.9 0.4 1.5e-07 31.4 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.10 ESA23911.1 - 5.7e-06 25.4 0.1 6.9e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 ESA23911.1 - 0.00055 19.9 0.0 0.00098 19.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 ESA23911.1 - 0.00089 18.9 0.0 0.0016 18.1 0.0 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 ESA23911.1 - 0.0047 16.6 0.1 0.0077 15.9 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 ESA23911.1 - 0.018 14.4 0.1 0.041 13.3 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DsrD PF08679.6 ESA23911.1 - 0.061 13.3 0.3 0.17 11.9 0.2 1.8 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) zf-C3HC4_3 PF13920.1 ESA23912.1 - 1.9e-07 30.6 7.4 1.9e-07 30.6 5.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 ESA23912.1 - 2.6e-07 30.5 9.7 2.6e-07 30.5 6.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 ESA23912.1 - 3.7e-07 29.8 8.2 3.7e-07 29.8 5.7 2.8 3 1 1 4 4 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESA23912.1 - 5.6e-07 29.1 8.5 5.6e-07 29.1 5.9 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA23912.1 - 9.9e-07 28.4 8.6 2.1e-06 27.4 5.7 1.8 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 ESA23912.1 - 3.5e-06 26.6 9.3 3.5e-06 26.6 6.4 2.5 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_6 PF14835.1 ESA23912.1 - 2.8e-05 23.8 4.5 2.8e-05 23.8 3.1 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 ESA23912.1 - 3.1e-05 23.5 8.3 8.9e-05 22.1 1.4 2.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-rbx1 PF12678.2 ESA23912.1 - 0.0021 18.1 5.7 0.0096 16.0 3.9 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_4 PF14570.1 ESA23912.1 - 0.0047 16.4 9.5 0.0054 16.2 1.6 3.1 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.9 ESA23912.1 - 0.0077 15.6 0.3 0.59 9.6 0.1 2.6 2 0 0 2 2 2 1 Rad50 zinc hook motif zinc-ribbons_6 PF07191.7 ESA23912.1 - 0.016 14.9 3.9 0.036 13.8 2.7 1.7 1 0 0 1 1 1 0 zinc-ribbons zf-MIZ PF02891.15 ESA23912.1 - 0.066 12.7 8.2 0.17 11.4 5.7 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger DUF2175 PF09943.4 ESA23912.1 - 0.075 13.1 0.6 0.15 12.1 0.4 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DUF1488 PF07369.6 ESA23912.1 - 0.15 11.9 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) zf-Apc11 PF12861.2 ESA23912.1 - 0.2 11.5 4.1 0.49 10.2 2.8 1.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 ESA23912.1 - 0.51 9.9 9.1 9.9 5.7 6.3 2.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Rtf2 PF04641.7 ESA23912.1 - 0.88 8.7 5.1 3 6.9 3.6 1.7 1 1 1 2 2 2 0 Rtf2 RING-finger zf-C2HC5 PF06221.8 ESA23912.1 - 1.8 8.3 7.2 0.51 10.1 2.4 2.1 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type Vps39_2 PF10367.4 ESA23912.1 - 3 8.0 8.0 0.78 9.9 0.6 2.7 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 2 zf-Di19 PF05605.7 ESA23912.1 - 7.3 6.8 8.2 2.7 8.1 0.1 2.8 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding VIGSSK PF14773.1 ESA23913.1 - 0.012 15.4 0.0 0.036 13.9 0.0 1.9 1 0 0 1 1 1 0 Helicase-associated putative binding domain, C-terminal Thiol_cytolysin PF01289.14 ESA23914.1 - 0.066 11.5 0.0 0.093 11.0 0.0 1.1 1 0 0 1 1 1 0 Thiol-activated cytolysin MULE PF10551.4 ESA23916.1 - 1.4e-06 28.3 0.4 3.9e-06 26.9 0.1 2.0 2 0 0 2 2 2 1 MULE transposase domain SWIM PF04434.12 ESA23916.1 - 0.0044 16.4 0.1 0.011 15.1 0.1 1.7 1 0 0 1 1 1 1 SWIM zinc finger FAM53 PF15242.1 ESA23916.1 - 0.029 13.9 1.0 0.047 13.2 0.7 1.2 1 0 0 1 1 1 0 Family of FAM53 zf-CCHC_2 PF13696.1 ESA23917.1 - 0.048 13.1 4.0 0.08 12.4 2.8 1.4 1 0 0 1 1 1 0 Zinc knuckle eIF3g PF12353.3 ESA23917.1 - 0.07 13.0 6.5 0.05 13.5 2.2 2.1 1 1 2 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC PF00098.18 ESA23917.1 - 0.07 13.0 5.1 0.16 11.9 3.6 1.7 1 1 0 1 1 1 0 Zinc knuckle Ion_trans PF00520.26 ESA23919.1 - 0.00089 18.5 8.5 0.00089 18.5 5.9 1.9 2 0 0 2 2 2 1 Ion transport protein Suppressor_APC PF11414.3 ESA23919.1 - 0.0082 15.9 2.5 0.052 13.3 0.8 2.2 2 0 0 2 2 2 1 Adenomatous polyposis coli tumour suppressor protein Muted PF14942.1 ESA23919.1 - 0.055 13.3 2.2 0.083 12.7 0.1 2.1 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein P4Ha_N PF08336.6 ESA23919.1 - 0.066 13.0 0.7 0.066 13.0 0.5 1.5 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Seryl_tRNA_N PF02403.17 ESA23919.1 - 0.23 11.4 5.3 4 7.5 0.7 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.1 ESA23919.1 - 1.4 8.8 4.1 1 9.3 0.6 1.9 2 0 0 2 2 2 0 FlxA-like protein Prefoldin PF02996.12 ESA23919.1 - 1.8 8.2 7.4 1.9 8.1 2.5 2.1 2 0 0 2 2 2 0 Prefoldin subunit DUF805 PF05656.9 ESA23919.1 - 4.1 7.2 7.2 1 9.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF805) EMP24_GP25L PF01105.19 ESA23919.1 - 8.2 6.1 7.7 1.5 8.5 0.3 2.6 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Sel1 PF08238.7 ESA23922.1 - 1.2e-120 391.2 61.2 1.1e-12 48.1 0.3 14.3 14 0 0 14 14 14 14 Sel1 repeat TPR_6 PF13174.1 ESA23922.1 - 2e-09 37.2 20.9 3.2 8.4 0.1 10.1 10 1 0 10 10 10 3 Tetratricopeptide repeat Aurora-A_bind PF09041.5 ESA23922.1 - 0.019 14.6 1.0 9.3 6.0 0.0 3.7 3 1 0 3 3 3 0 Aurora-A binding Flu_M1_C PF08289.6 ESA23922.1 - 0.031 14.2 1.0 28 4.8 0.0 5.2 5 1 3 8 8 8 0 Influenza Matrix protein (M1) C-terminal domain TPR_17 PF13431.1 ESA23922.1 - 0.23 11.7 28.0 0.39 11.0 0.2 9.8 10 2 2 12 12 12 0 Tetratricopeptide repeat TPR_19 PF14559.1 ESA23922.1 - 0.58 10.5 15.9 6 7.2 0.1 6.5 6 1 0 6 6 6 0 Tetratricopeptide repeat RQC PF09382.5 ESA23922.1 - 0.62 9.8 6.6 0.66 9.7 0.3 3.5 3 1 0 3 3 3 0 RQC domain Ion_trans PF00520.26 ESA23924.1 - 3.9e-08 32.7 8.9 7.8e-08 31.8 6.1 1.4 1 0 0 1 1 1 1 Ion transport protein DUF131 PF01998.12 ESA23924.1 - 2 7.8 5.0 4.1 6.8 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF131 PKD_channel PF08016.7 ESA23924.1 - 2.2 6.6 17.4 0.069 11.5 0.7 2.2 1 1 1 2 2 2 0 Polycystin cation channel TPR_1 PF00515.23 ESA23929.1 - 3.5e-05 23.2 0.1 3.5e-05 23.2 0.1 1.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 ESA23929.1 - 8e-05 22.2 0.0 8e-05 22.2 0.0 1.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 ESA23929.1 - 0.0001 21.8 0.1 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 TPR repeat TPR_17 PF13431.1 ESA23929.1 - 0.0037 17.3 0.2 0.029 14.5 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ELYS PF13934.1 ESA23929.1 - 0.015 15.0 0.5 0.015 15.0 0.4 1.1 1 0 0 1 1 1 0 Nuclear pore complex assembly TPR_9 PF13371.1 ESA23929.1 - 0.026 14.3 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Mem_trans PF03547.13 ESA23930.1 - 2.5e-41 141.2 14.9 3.7e-41 140.6 10.3 1.2 1 0 0 1 1 1 1 Membrane transport protein EF-hand_4 PF12763.2 ESA23931.1 - 0.085 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF1443 PF07280.6 ESA23932.1 - 0.2 11.2 2.8 0.27 10.8 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1443) Chordopox_L2 PF05803.7 ESA23933.1 - 0.027 14.1 0.2 6.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Chordopoxvirus L2 protein zf-RING_2 PF13639.1 ESA23934.1 - 0.026 14.3 2.6 0.058 13.2 1.8 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 ESA23934.1 - 0.033 14.2 0.9 0.084 12.9 0.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3150 PF11348.3 ESA23934.1 - 0.041 12.9 0.2 0.072 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) zf-RING_UBOX PF13445.1 ESA23934.1 - 0.042 13.5 0.7 0.13 11.9 0.5 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.1 ESA23934.1 - 0.09 12.4 0.9 0.18 11.5 0.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23934.1 - 0.2 11.3 1.9 0.58 9.8 1.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA23934.1 - 0.22 11.2 4.7 0.47 10.2 3.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA23935.1 - 0.0023 17.8 1.4 0.0053 16.7 1.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA23935.1 - 0.0025 17.6 3.8 0.014 15.2 3.0 2.0 1 1 1 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.1 ESA23935.1 - 0.008 15.8 1.2 0.026 14.2 0.8 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 ESA23935.1 - 0.0091 15.7 4.4 0.017 14.8 3.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Gasdermin PF04598.7 ESA23935.1 - 0.018 13.8 0.1 0.027 13.2 0.1 1.2 1 0 0 1 1 1 0 Gasdermin family FSA_C PF10479.4 ESA23935.1 - 0.019 13.0 0.2 0.027 12.5 0.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus zf-rbx1 PF12678.2 ESA23935.1 - 0.031 14.3 1.5 0.067 13.3 1.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 ESA23935.1 - 0.031 13.9 2.1 0.056 13.1 1.5 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23935.1 - 0.032 13.9 3.9 0.12 12.0 2.8 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NDT80_PhoG PF05224.7 ESA23935.1 - 0.053 13.5 0.9 1.8 8.5 0.3 2.1 2 0 0 2 2 2 0 NDT80 / PhoG like DNA-binding family HNOB PF07700.10 ESA23935.1 - 0.15 11.5 0.7 5.2 6.5 0.0 2.5 3 0 0 3 3 3 0 Heme NO binding zf-C3HC4_4 PF15227.1 ESA23935.1 - 0.16 11.8 2.1 1.5 8.7 1.2 2.4 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Topoisom_I_N PF02919.10 ESA23935.1 - 0.76 9.0 6.7 0.055 12.7 1.4 1.4 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment zf-RING_2 PF13639.1 ESA23936.1 - 0.017 14.9 0.3 0.034 13.9 0.2 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 ESA23936.1 - 0.017 14.8 0.1 0.047 13.4 0.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.1 ESA23936.1 - 0.023 14.6 0.2 0.065 13.2 0.0 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA23936.1 - 0.054 13.1 0.9 0.16 11.6 0.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 ESA23936.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger Arm PF00514.18 ESA23937.1 - 2.9e-39 131.5 23.4 1.9e-07 30.6 0.0 11.3 12 0 0 12 12 12 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 ESA23937.1 - 5.5e-22 77.8 11.2 1.2e-06 28.7 0.0 7.3 2 2 3 7 7 7 7 HEAT repeats HEAT PF02985.17 ESA23937.1 - 1.8e-17 61.7 25.3 0.0053 16.7 0.1 11.2 12 0 0 12 12 12 5 HEAT repeat HEAT_EZ PF13513.1 ESA23937.1 - 1.5e-13 50.7 16.7 0.42 11.1 0.0 10.0 7 1 3 10 10 10 4 HEAT-like repeat Arm_2 PF04826.8 ESA23937.1 - 2.5e-06 26.7 11.7 3.8e-05 22.9 0.4 5.1 4 2 2 6 6 6 1 Armadillo-like V-ATPase_H_N PF03224.9 ESA23937.1 - 4.1e-06 26.1 2.6 0.00057 19.1 0.6 3.6 1 1 1 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 ESA23937.1 - 1.5e-05 24.8 9.4 0.032 14.1 0.0 5.1 6 1 1 7 7 7 2 V-ATPase subunit H Ric8 PF10165.4 ESA23937.1 - 5.9e-05 22.0 3.9 0.0024 16.7 0.5 2.8 1 1 1 2 2 2 2 Guanine nucleotide exchange factor synembryn DUF2435 PF10363.4 ESA23937.1 - 9.8e-05 22.1 2.7 0.31 10.9 0.0 4.9 4 1 1 5 5 5 1 Protein of unknown function (DUF2435) Cnd1 PF12717.2 ESA23937.1 - 0.00049 19.9 12.2 2.1 8.1 0.1 6.1 3 2 3 6 6 6 1 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.1 ESA23937.1 - 0.013 14.7 1.2 0.34 10.1 0.4 3.3 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II Ipi1_N PF12333.3 ESA23937.1 - 0.018 15.0 0.9 1.6 8.7 0.1 3.9 4 0 0 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation DUF2454 PF10521.4 ESA23937.1 - 0.091 11.7 7.5 7.1 5.5 0.1 4.8 4 3 1 5 5 5 0 Protein of unknown function (DUF2454) NTNH_C PF08470.5 ESA23941.1 - 0.0053 16.4 3.3 0.0068 16.0 2.3 1.1 1 0 0 1 1 1 1 Nontoxic nonhaemagglutinin C-terminal TLD PF07534.11 ESA23942.1 - 9.2e-14 51.6 0.8 9.2e-14 51.6 0.5 1.4 2 0 0 2 2 2 1 TLD Polysacc_synt_4 PF04669.8 ESA23944.1 - 0.12 11.7 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis ChlamPMP_M PF07548.6 ESA23944.1 - 1.4 8.6 7.5 2.6 7.7 5.2 1.6 1 1 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain DUF1446 PF07287.6 ESA23949.1 - 2.5e-114 381.5 0.0 3.3e-114 381.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1446) DUF1031 PF06275.6 ESA23951.1 - 0.011 15.7 0.1 0.022 14.7 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1031) ANAPC15 PF15243.1 ESA23951.1 - 0.22 11.5 4.7 0.31 11.1 3.3 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF2201_N PF13203.1 ESA23952.1 - 0.064 12.4 0.6 0.077 12.1 0.4 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Trypan_PARP PF05887.6 ESA23952.1 - 2.2 8.0 6.2 3.1 7.6 4.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Tom22 PF04281.8 ESA23952.1 - 5.3 6.5 7.2 10 5.6 5.0 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 CobT PF06213.7 ESA23952.1 - 5.4 6.0 8.8 7 5.6 6.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_p85B PF02192.11 ESA23953.1 - 0.061 12.7 0.1 0.18 11.2 0.1 1.8 1 0 0 1 1 1 0 PI3-kinase family, p85-binding domain RL11D PF11088.3 ESA23954.1 - 0.0049 16.6 0.9 0.019 14.7 0.1 2.0 2 0 0 2 2 2 1 Glycoprotein encoding membrane proteins RL5A and RL6 zf-BED PF02892.10 ESA23955.1 - 0.0056 16.4 0.1 0.012 15.2 0.1 1.6 1 0 0 1 1 1 1 BED zinc finger zf-BED PF02892.10 ESA23956.1 - 0.0076 15.9 0.1 0.014 15.1 0.1 1.4 1 0 0 1 1 1 1 BED zinc finger F-box-like PF12937.2 ESA23957.1 - 0.0034 17.0 0.4 0.012 15.3 0.3 1.9 1 0 0 1 1 1 1 F-box-like Toxin_35 PF10530.4 ESA23957.1 - 1.4 9.0 9.3 0.51 10.4 3.1 2.4 2 0 0 2 2 2 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold DUF1034 PF06280.7 ESA23958.1 - 0.011 16.1 1.5 0.093 13.1 0.8 2.2 2 0 0 2 2 2 0 Fn3-like domain (DUF1034) Coatomer_b_Cpla PF14806.1 ESA23959.1 - 5.2e-70 233.1 0.1 1e-69 232.2 0.1 1.5 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 ESA23959.1 - 9.1e-65 216.6 0.5 2.2e-64 215.3 0.1 1.8 2 0 0 2 2 2 1 Coatomer beta C-terminal region SHS2_Rpb7-N PF03876.12 ESA23960.1 - 4.6e-13 49.0 0.0 7.8e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 ESA23960.1 - 1.2e-12 47.7 0.1 1.9e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 ESA23960.1 - 1.2e-06 28.7 0.0 1.8e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 KaiA PF07688.7 ESA23960.1 - 0.031 13.5 0.1 2.5 7.3 0.0 2.1 2 0 0 2 2 2 0 KaiA domain CBM_20 PF00686.14 ESA23962.1 - 0.00054 19.5 0.0 0.0042 16.6 0.0 2.3 2 0 0 2 2 2 1 Starch binding domain DUF3947 PF13135.1 ESA23963.1 - 0.055 13.6 0.8 0.068 13.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) DUF2811 PF10929.3 ESA23964.1 - 0.078 13.0 0.1 0.16 12.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2811) SAP PF02037.22 ESA23965.1 - 3.1e-05 23.3 0.0 6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 SAP domain zf-C3HC4_4 PF15227.1 ESA23965.1 - 6.8e-05 22.6 13.5 0.00014 21.7 9.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 ESA23965.1 - 0.00014 21.4 13.4 0.00026 20.5 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 ESA23965.1 - 0.0018 17.9 0.8 0.0018 17.9 0.6 3.1 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.1 ESA23965.1 - 0.003 17.5 12.5 0.0059 16.5 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 ESA23965.1 - 0.0058 16.4 2.3 0.011 15.5 1.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 ESA23965.1 - 0.013 15.2 3.0 0.027 14.2 2.1 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 ESA23965.1 - 0.015 14.9 13.6 0.029 14.0 9.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.1 ESA23965.1 - 0.017 14.7 8.8 0.028 14.0 6.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 ESA23965.1 - 0.032 14.0 10.7 0.057 13.2 7.4 1.4 1 0 0 1 1 1 0 Ring finger domain zf-MIZ PF02891.15 ESA23965.1 - 0.075 12.5 8.6 0.13 11.8 5.9 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Prok-RING_4 PF14447.1 ESA23965.1 - 0.49 9.9 7.4 1.2 8.7 5.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 ORC6 PF05460.8 ESA23966.1 - 1.2e-07 31.1 6.3 6.7e-06 25.4 0.1 2.3 2 0 0 2 2 2 2 Origin recognition complex subunit 6 (ORC6) FCP1_C PF09309.5 ESA23966.1 - 0.011 15.1 5.9 0.017 14.4 4.1 1.3 1 0 0 1 1 1 0 FCP1, C-terminal ADK PF00406.17 ESA23967.1 - 9e-61 204.1 0.6 1.5e-60 203.4 0.0 1.5 2 0 0 2 2 2 1 Adenylate kinase ADK_lid PF05191.9 ESA23967.1 - 4e-15 55.1 0.0 9.1e-15 54.0 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 ESA23967.1 - 0.00097 19.9 0.1 0.0031 18.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 ESA23967.1 - 0.0054 15.8 0.0 0.0092 15.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 ESA23967.1 - 0.015 15.6 0.0 0.048 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 ESA23967.1 - 0.018 14.9 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain XhlA PF10779.4 ESA23967.1 - 0.25 11.2 3.2 5.9 6.8 0.1 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Swi3 PF07962.7 ESA23968.1 - 0.0068 16.0 0.0 0.0086 15.6 0.0 1.1 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Pkinase_Tyr PF07714.12 ESA23970.1 - 5.6e-17 61.6 0.0 8.7e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23970.1 - 9.7e-15 54.4 0.0 1.5e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CO_dh PF02552.11 ESA23970.1 - 0.00031 20.3 1.0 0.00048 19.7 0.7 1.3 1 0 0 1 1 1 1 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Pkinase PF00069.20 ESA23971.1 - 7e-21 74.5 0.3 7e-21 74.5 0.2 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23971.1 - 1.9e-18 66.5 0.0 2.8e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3960 PF13142.1 ESA23971.1 - 0.014 15.1 3.3 2.2 8.0 0.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3960) DUF2616 PF11077.3 ESA23971.1 - 0.018 14.5 3.4 0.22 11.0 0.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2616) Stc1 PF12898.2 ESA23971.1 - 0.028 14.4 1.0 0.05 13.6 0.7 1.5 1 0 0 1 1 1 0 Stc1 domain zinc-ribbons_6 PF07191.7 ESA23971.1 - 0.037 13.8 3.3 0.06 13.1 2.3 1.3 1 0 0 1 1 1 0 zinc-ribbons CpXC PF14353.1 ESA23971.1 - 0.092 12.7 0.9 1.4 8.9 0.0 2.2 1 1 1 2 2 2 0 CpXC protein PKD_channel PF08016.7 ESA23972.1 - 0.095 11.1 7.9 0.14 10.5 5.5 1.2 1 0 0 1 1 1 0 Polycystin cation channel OAD_gamma PF04277.8 ESA23972.1 - 0.14 12.5 0.3 0.14 12.5 0.2 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PGG PF13962.1 ESA23972.1 - 9.1 5.9 8.9 0.25 10.9 0.3 2.2 2 1 0 2 2 2 0 Domain of unknown function Nucleocapsid-N PF11030.3 ESA23973.1 - 0.019 14.7 0.3 0.021 14.6 0.2 1.1 1 0 0 1 1 1 0 Nucleocapsid protein N FYRC PF05965.9 ESA23974.1 - 0.016 15.0 0.4 0.59 9.9 0.0 3.1 2 1 0 2 2 2 0 F/Y rich C-terminus FtsK_SpoIIIE PF01580.13 ESA23976.1 - 0.0077 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.1 ESA23976.1 - 0.05 13.5 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 ESA23976.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_10 PF12846.2 ESA23976.1 - 0.14 11.5 0.1 0.97 8.8 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 ESA23976.1 - 0.16 12.8 2.4 0.17 12.7 0.4 1.9 2 1 0 2 2 2 0 AAA domain T2SE PF00437.15 ESA23976.1 - 0.96 8.2 3.2 0.34 9.7 0.2 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein ScpA_ScpB PF02616.9 ESA23977.1 - 0.0056 16.3 2.9 0.0069 15.9 2.0 1.1 1 0 0 1 1 1 1 ScpA/B protein OmpH PF03938.9 ESA23977.1 - 0.061 13.2 3.2 0.08 12.8 2.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MecA_N PF05223.6 ESA23977.1 - 0.069 13.2 3.1 0.087 12.8 2.1 1.1 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain Bystin PF05291.6 ESA23977.1 - 0.19 10.6 2.6 0.24 10.2 1.8 1.1 1 0 0 1 1 1 0 Bystin DUF4659 PF15558.1 ESA23977.1 - 0.25 9.9 11.9 0.32 9.5 8.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4659) DUF883 PF05957.8 ESA23977.1 - 0.66 10.4 3.3 0.96 9.8 2.3 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.2 ESA23977.1 - 3 8.2 7.1 6.3 7.2 4.9 1.7 1 1 0 1 1 1 0 YtxH-like protein U1snRNP70_N PF12220.3 ESA23977.1 - 3.8 7.8 7.2 6.1 7.2 5.0 1.4 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal XG_FTase PF03254.8 ESA23978.1 - 8.8e-10 37.6 2.2 1.1e-06 27.4 0.0 2.8 1 1 1 3 3 3 2 Xyloglucan fucosyltransferase Amidohydro_3 PF07969.6 ESA23978.1 - 0.28 10.3 0.0 0.4 9.8 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family Borrelia_rep PF03183.8 ESA23980.1 - 0.7 9.7 3.1 2 8.3 2.1 1.8 1 0 0 1 1 1 0 Borrelia repeat protein Pkinase PF00069.20 ESA23981.1 - 3e-27 95.4 0.0 8.4e-27 93.9 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA23981.1 - 1.9e-26 92.6 0.0 2.4e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1794 PF08768.6 ESA23982.1 - 0.043 13.6 0.0 0.056 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1794) SPRY PF00622.23 ESA23983.1 - 3e-08 33.7 0.0 3.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Myelin_PLP PF01275.14 ESA23983.1 - 0.062 12.6 0.0 0.078 12.3 0.0 1.1 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) BTB PF00651.26 ESA23984.1 - 9.7e-15 54.5 0.9 6.3e-14 51.9 0.1 2.4 1 1 2 3 3 3 1 BTB/POZ domain SPRY PF00622.23 ESA23984.1 - 5.4e-14 52.3 0.1 1.1e-13 51.3 0.1 1.5 1 0 0 1 1 1 1 SPRY domain Skp1_POZ PF03931.10 ESA23984.1 - 4e-05 23.6 0.1 0.014 15.4 0.0 3.1 2 2 0 2 2 2 2 Skp1 family, tetramerisation domain F-box-like PF12937.2 ESA23988.1 - 0.00056 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like HHH_3 PF12836.2 ESA23989.1 - 0.0015 18.4 0.5 0.0019 18.1 0.3 1.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif NYD-SP28_assoc PF14775.1 ESA23989.1 - 0.0025 17.4 2.0 0.0049 16.5 1.0 1.7 1 1 1 2 2 2 1 Sperm tail C-terminal domain Leu_zip PF15294.1 ESA23989.1 - 0.0034 16.5 1.4 0.0034 16.5 1.0 1.0 1 0 0 1 1 1 1 Leucine zipper HALZ PF02183.13 ESA23989.1 - 0.014 15.0 1.8 0.014 15.0 1.2 1.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper CCDC155 PF14662.1 ESA23989.1 - 0.024 14.2 0.2 0.027 14.0 0.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 bZIP_1 PF00170.16 ESA23989.1 - 0.054 13.4 2.8 0.067 13.1 2.0 1.3 1 0 0 1 1 1 0 bZIP transcription factor FliT PF05400.8 ESA23989.1 - 0.058 13.7 0.2 0.061 13.7 0.1 1.1 1 0 0 1 1 1 0 Flagellar protein FliT Mto2_bdg PF12808.2 ESA23989.1 - 0.15 12.1 2.7 0.21 11.7 1.4 1.6 1 1 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_2 PF07716.10 ESA23989.1 - 0.15 11.8 3.6 0.58 10.0 0.6 2.1 1 1 1 2 2 2 0 Basic region leucine zipper DivIC PF04977.10 ESA23989.1 - 0.4 10.2 2.2 0.6 9.6 1.5 1.6 1 1 0 1 1 1 0 Septum formation initiator RNA_pol_Rpb2_5 PF04567.12 ESA23990.1 - 0.015 15.2 4.0 0.39 10.7 0.1 3.2 3 1 0 3 3 3 0 RNA polymerase Rpb2, domain 5 Sel1 PF08238.7 ESA23991.1 - 3.9e-156 504.1 72.9 1.7e-13 50.7 0.4 17.5 17 0 0 17 17 17 17 Sel1 repeat Pkinase_Tyr PF07714.12 ESA23991.1 - 3.1e-40 137.9 0.0 4.8e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA23991.1 - 2.6e-36 125.1 0.1 4.6e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TPR_6 PF13174.1 ESA23991.1 - 8.4e-10 38.4 39.2 0.19 12.2 0.1 12.6 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_16 PF13432.1 ESA23991.1 - 2.8e-09 37.3 8.1 0.66 10.7 0.0 7.6 5 2 3 9 9 9 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA23991.1 - 1.5e-08 34.4 32.0 0.00051 19.9 0.9 10.1 8 3 3 11 11 9 4 Tetratricopeptide repeat TPR_14 PF13428.1 ESA23991.1 - 5.6e-07 29.6 1.3 17 6.3 0.0 7.5 5 2 4 9 9 7 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA23991.1 - 5.9e-05 22.4 1.8 5.9e-05 22.4 1.3 10.9 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_8 PF13181.1 ESA23991.1 - 0.00081 18.9 1.5 0.00081 18.9 1.1 12.1 14 1 0 14 14 13 2 Tetratricopeptide repeat TPR_2 PF07719.12 ESA23991.1 - 0.003 17.3 0.9 0.003 17.3 0.6 13.4 15 1 0 15 15 14 3 Tetratricopeptide repeat Kdo PF06293.9 ESA23991.1 - 0.0053 15.8 0.0 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA23991.1 - 0.0067 15.8 0.2 0.017 14.4 0.1 1.6 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.4 ESA23991.1 - 0.017 14.4 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TPR_11 PF13414.1 ESA23991.1 - 0.068 12.8 51.7 0.1 12.2 6.1 9.5 3 2 6 9 9 9 0 TPR repeat TPR_10 PF13374.1 ESA23991.1 - 0.25 11.3 0.3 20 5.2 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA23991.1 - 0.46 10.4 15.6 4 7.4 0.1 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat HSP70 PF00012.15 ESA23992.1 - 6.3e-07 27.6 0.0 7e-07 27.5 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein RanGAP1_C PF07834.6 ESA23994.1 - 0.06 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 RanGAP1 C-terminal domain Turandot PF07240.6 ESA23995.1 - 0.12 11.9 1.0 1.9 8.0 0.1 3.1 3 0 0 3 3 3 0 Stress-inducible humoral factor Turandot Dimer_Tnp_hAT PF05699.9 ESA23996.1 - 6.5e-21 73.7 0.8 8e-21 73.4 0.5 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Reeler PF02014.11 ESA23997.1 - 2.8e-07 30.8 0.0 3.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Reeler domain HMG_box PF00505.14 ESA23998.1 - 2e-07 31.1 0.0 3.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA23998.1 - 2e-05 24.8 0.0 3.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain UDG PF03167.14 ESA23999.1 - 8.9e-09 34.9 0.0 1.4e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily RelB_N PF12910.2 ESA23999.1 - 0.13 11.6 0.1 7 6.0 0.0 2.3 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin stability system N-terminal adh_short PF00106.20 ESA24000.1 - 2.5e-23 82.7 0.0 3.2e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA24000.1 - 7.7e-10 38.9 0.0 1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA24000.1 - 9e-05 22.2 0.1 0.0002 21.0 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 ESA24000.1 - 0.0021 17.5 0.1 0.0047 16.3 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 ESA24000.1 - 0.16 11.9 1.3 0.27 11.2 0.9 1.5 1 1 0 1 1 1 0 NADH(P)-binding MazG-like PF12643.2 ESA24001.1 - 0.071 13.0 0.1 0.071 13.0 0.1 2.0 2 0 0 2 2 2 0 MazG-like family FliD_C PF07195.7 ESA24002.1 - 0.0002 20.7 0.2 0.00025 20.4 0.1 1.1 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus NPV_P10 PF05531.7 ESA24002.1 - 0.0019 18.4 0.2 0.035 14.3 0.0 2.1 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Nsp1_C PF05064.8 ESA24002.1 - 0.0062 16.1 0.2 0.3 10.7 0.2 2.1 2 0 0 2 2 2 1 Nsp1-like C-terminal region Vac_Fusion PF02346.11 ESA24002.1 - 0.011 15.0 2.6 2.1 7.8 0.2 3.3 2 1 1 3 3 3 0 Chordopoxvirus fusion protein Prefoldin_2 PF01920.15 ESA24002.1 - 0.015 15.0 0.3 0.015 15.0 0.2 2.2 2 1 0 2 2 2 0 Prefoldin subunit FUN14 PF04930.10 ESA24002.1 - 0.02 15.1 0.2 0.053 13.8 0.1 1.6 1 1 1 2 2 2 0 FUN14 family UPF0184 PF03670.8 ESA24002.1 - 0.04 14.1 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Fzo_mitofusin PF04799.8 ESA24002.1 - 0.044 13.1 0.8 0.14 11.5 0.2 1.9 1 1 1 2 2 2 0 fzo-like conserved region Snapin_Pallidin PF14712.1 ESA24002.1 - 0.062 13.6 0.7 4 7.8 0.1 2.7 2 1 1 3 3 3 0 Snapin/Pallidin DivIC PF04977.10 ESA24002.1 - 0.068 12.6 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 Septum formation initiator Dynamitin PF04912.9 ESA24002.1 - 0.069 11.9 0.6 0.47 9.1 0.1 2.1 1 1 1 2 2 2 0 Dynamitin XhlA PF10779.4 ESA24002.1 - 0.085 12.7 2.4 3.2 7.7 0.6 2.6 2 0 0 2 2 2 0 Haemolysin XhlA BLOC1_2 PF10046.4 ESA24002.1 - 0.085 12.9 1.5 0.99 9.5 0.7 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ax_dynein_light PF10211.4 ESA24002.1 - 0.087 12.6 0.7 0.13 12.0 0.5 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Scm3 PF10384.4 ESA24002.1 - 0.09 12.2 2.1 0.38 10.2 0.1 2.5 2 1 0 2 2 2 0 Centromere protein Scm3 RmuC PF02646.11 ESA24002.1 - 0.1 11.4 1.1 0.5 9.1 0.3 1.9 2 0 0 2 2 2 0 RmuC family TMF_DNA_bd PF12329.3 ESA24002.1 - 0.14 12.0 0.5 0.14 12.0 0.3 2.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding MtrG PF04210.8 ESA24002.1 - 0.16 11.7 2.6 3.1 7.5 0.6 2.7 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Osmo_CC PF08946.5 ESA24002.1 - 0.29 11.1 3.3 7.9 6.5 0.8 2.5 1 1 1 2 2 2 0 Osmosensory transporter coiled coil Hemagglutinin PF00509.13 ESA24002.1 - 1.9 6.5 5.4 0.45 8.6 1.8 1.4 2 0 0 2 2 2 0 Haemagglutinin DUF4413 PF14372.1 ESA24003.1 - 0.84 9.6 11.0 0.17 11.9 0.4 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4413) DZR PF12773.2 ESA24003.1 - 5.2 6.9 8.3 0.53 10.1 0.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon Pkinase_Tyr PF07714.12 ESA24005.1 - 6.6e-44 149.9 0.0 8.4e-44 149.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24005.1 - 3e-41 141.2 0.2 5.5e-41 140.4 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain BCS1_N PF08740.6 ESA24005.1 - 0.0018 17.9 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal APH PF01636.18 ESA24005.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-3CxxC PF13695.1 ESA24007.1 - 0.036 14.2 0.4 0.039 14.1 0.3 1.0 1 0 0 1 1 1 0 Zinc-binding domain zf-RING_2 PF13639.1 ESA24007.1 - 0.047 13.5 2.2 0.1 12.4 1.6 1.6 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.1 ESA24007.1 - 0.059 13.4 2.4 0.26 11.3 1.9 1.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Dimer_Tnp_hAT PF05699.9 ESA24009.1 - 1.1e-16 60.1 0.0 1.2e-16 60.0 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region HMG_box PF00505.14 ESA24014.1 - 4.2e-07 30.1 4.4 1.5e-06 28.3 3.1 1.7 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA24014.1 - 7.6e-07 29.4 3.6 1.1e-06 28.9 2.5 1.2 1 1 0 1 1 1 1 HMG-box domain COX4 PF02936.9 ESA24014.1 - 0.015 15.0 0.7 0.015 15.0 0.5 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV DUF736 PF05284.7 ESA24014.1 - 0.053 13.3 0.1 0.058 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF736) DUF1074 PF06382.6 ESA24014.1 - 0.11 12.4 0.5 0.12 12.3 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1074) DUF1410 PF07198.6 ESA24015.1 - 0.78 10.1 5.8 2.6 8.4 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1410) 2OG-FeII_Oxy_2 PF13532.1 ESA24017.1 - 1.1e-31 110.1 0.0 1.3e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESA24017.1 - 3.6e-06 27.1 0.0 7.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ubiquitin_2 PF14560.1 ESA24017.1 - 0.02 15.1 0.1 0.09 13.0 0.0 2.1 3 0 0 3 3 3 0 Ubiquitin-like domain ETC_C1_NDUFA4 PF04800.7 ESA24018.1 - 1.2e-29 102.0 0.2 1.4e-29 101.9 0.1 1.0 1 0 0 1 1 1 1 ETC complex I subunit conserved region DUF3892 PF13031.1 ESA24018.1 - 0.043 14.2 0.0 0.053 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) Ras PF00071.17 ESA24019.1 - 1.3e-55 187.1 0.0 1.5e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 ESA24019.1 - 3.1e-20 72.8 0.0 4.2e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 ESA24019.1 - 1.4e-07 30.9 0.1 1.7e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 ESA24019.1 - 3.9e-05 23.1 0.1 0.00029 20.3 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 ESA24019.1 - 0.00029 20.7 0.0 0.00034 20.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 ESA24019.1 - 0.018 14.1 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_25 PF13481.1 ESA24019.1 - 0.03 13.7 0.1 0.05 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain CbiA PF01656.18 ESA24019.1 - 0.13 11.6 0.1 0.3 10.4 0.1 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain OAD_gamma PF04277.8 ESA24020.1 - 6.8 7.1 6.0 0.56 10.6 0.9 1.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Casein_kappa PF00997.13 ESA24021.1 - 1.6 8.4 4.7 0.36 10.5 1.3 1.4 2 0 0 2 2 2 0 Kappa casein Thy1 PF02511.10 ESA24023.1 - 0.079 12.2 0.6 0.094 12.0 0.4 1.2 1 0 0 1 1 1 0 Thymidylate synthase complementing protein BAF1_ABF1 PF04684.8 ESA24024.1 - 0.013 14.3 16.4 0.015 14.2 11.4 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor CEP76-C2 PF15627.1 ESA24024.1 - 0.27 10.7 2.6 0.39 10.2 1.8 1.2 1 0 0 1 1 1 0 CEP76 C2 domain LEF-4 PF05098.7 ESA24025.1 - 0.11 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Late expression factor 4 (LEF-4) F-box-like PF12937.2 ESA24026.1 - 0.022 14.5 5.1 0.022 14.4 2.0 2.2 2 0 0 2 2 2 0 F-box-like DUF1495 PF07381.6 ESA24027.1 - 0.13 11.9 0.1 0.27 10.9 0.0 1.5 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) CAP_C PF08603.6 ESA24028.1 - 9.6e-61 203.7 6.0 1.2e-60 203.4 4.1 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.14 ESA24028.1 - 4.4e-21 75.4 14.7 4.4e-21 75.4 10.2 1.5 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.7 ESA24028.1 - 0.011 15.1 1.9 0.017 14.5 1.3 1.3 1 0 0 1 1 1 0 Tubulin binding cofactor C SIR2 PF02146.12 ESA24029.1 - 6.8e-54 182.2 0.0 8.3e-54 181.9 0.0 1.1 1 0 0 1 1 1 1 Sir2 family CorA PF01544.13 ESA24030.1 - 2.6e-46 157.9 2.7 3.1e-46 157.7 1.8 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Exo_endo_phos_2 PF14529.1 ESA24035.1 - 5.5e-10 38.8 0.2 1.8e-09 37.2 0.1 1.9 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.18 ESA24035.1 - 2.8e-05 24.1 0.0 4.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SDA1 PF05285.7 ESA24038.1 - 0.18 11.0 33.7 0.36 10.0 23.4 1.4 1 0 0 1 1 1 0 SDA1 Neur_chan_memb PF02932.11 ESA24038.1 - 1 9.2 4.2 1.7 8.4 2.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nop14 PF04147.7 ESA24038.1 - 2.2 6.1 36.9 3.3 5.5 25.6 1.1 1 0 0 1 1 1 0 Nop14-like family Herpes_DNAp_acc PF04929.7 ESA24038.1 - 2.7 6.8 9.9 3.9 6.3 6.9 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Astro_capsid PF03115.9 ESA24038.1 - 4.9 5.2 7.1 7 4.7 4.9 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor TPR_11 PF13414.1 ESA24039.1 - 8.7e-11 41.3 1.1 6.8e-09 35.2 0.0 3.2 2 1 0 3 3 3 1 TPR repeat SET PF00856.23 ESA24039.1 - 8e-10 39.2 0.2 2.7e-09 37.5 0.0 2.1 2 1 0 2 2 1 1 SET domain TPR_16 PF13432.1 ESA24039.1 - 2.1e-08 34.6 0.9 0.00017 22.1 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 ESA24039.1 - 7.4e-07 29.2 0.4 4.1e-05 23.6 0.1 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 ESA24039.1 - 2e-06 27.2 3.9 5.6 7.1 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 ESA24039.1 - 0.0001 22.5 1.4 1.1 9.5 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA24039.1 - 0.00012 21.5 0.4 27 4.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 ESA24039.1 - 0.00098 19.1 0.5 0.33 11.2 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 ESA24039.1 - 0.0077 16.7 1.7 15 6.5 0.0 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat PPR PF01535.15 ESA24039.1 - 0.016 15.1 1.2 0.094 12.7 0.0 2.9 3 0 0 3 3 2 0 PPR repeat PPR_3 PF13812.1 ESA24039.1 - 0.05 13.8 0.0 0.41 11.0 0.0 2.5 2 0 0 2 2 2 0 Pentatricopeptide repeat domain TPR_12 PF13424.1 ESA24039.1 - 0.059 13.3 1.0 8.8 6.3 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 ESA24039.1 - 0.066 13.0 0.6 7.2 6.5 0.0 3.3 3 1 1 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 ESA24039.1 - 0.073 12.9 0.2 0.43 10.4 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat PPR_1 PF12854.2 ESA24039.1 - 7.9 6.0 6.8 0.86 9.1 0.0 2.7 3 0 0 3 3 2 0 PPR repeat HMG_box PF00505.14 ESA24040.1 - 3.9e-05 23.8 0.1 7.6e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA24040.1 - 0.0069 16.7 0.0 0.0099 16.2 0.0 1.3 1 0 0 1 1 1 1 HMG-box domain Sel1 PF08238.7 ESA24041.1 - 1.9e-87 285.7 43.3 6.1e-10 39.4 0.3 12.4 11 1 1 12 12 12 12 Sel1 repeat Pkinase_Tyr PF07714.12 ESA24041.1 - 1.6e-48 165.0 0.0 2.6e-48 164.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24041.1 - 2.5e-43 148.1 0.2 4.4e-43 147.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain TPR_6 PF13174.1 ESA24041.1 - 1.2e-07 31.7 20.3 2.4 8.8 0.1 8.3 9 0 0 9 9 9 4 Tetratricopeptide repeat Kdo PF06293.9 ESA24041.1 - 0.0065 15.5 0.1 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 ESA24041.1 - 0.02 13.8 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 ESA24041.1 - 0.05 13.3 0.1 0.12 12.1 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Sel1 PF08238.7 ESA24042.1 - 6.8e-12 45.6 1.2 5.6e-11 42.7 0.8 2.0 2 0 0 2 2 2 1 Sel1 repeat PGC7_Stella PF15549.1 ESA24044.1 - 0.00049 20.1 1.4 0.0011 19.0 0.0 1.9 1 1 1 2 2 2 1 PGC7/Stella/Dppa3 domain RhoGAP PF00620.22 ESA24044.1 - 0.058 13.0 1.2 0.24 11.0 0.1 2.0 2 0 0 2 2 2 0 RhoGAP domain Adeno_E1A PF02703.9 ESA24044.1 - 0.087 12.2 1.4 0.09 12.2 0.4 1.5 1 1 0 1 1 1 0 Early E1A protein Drf_GBD PF06371.8 ESA24045.1 - 0.0038 16.5 0.2 0.0067 15.7 0.1 1.5 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain RFC1 PF08519.7 ESA24046.1 - 0.0035 17.1 2.9 1.3 8.7 0.1 2.4 2 1 0 2 2 2 2 Replication factor RFC1 C terminal domain Spore_III_AB PF09548.5 ESA24046.1 - 0.012 15.3 0.8 0.026 14.2 0.5 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) ApoC-I PF04691.7 ESA24046.1 - 0.045 13.4 4.7 0.052 13.2 0.1 3.1 2 2 1 3 3 3 0 Apolipoprotein C-I (ApoC-1) DUF3714 PF12508.3 ESA24046.1 - 0.074 12.4 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3714) DUF3529 PF12046.3 ESA24046.1 - 0.085 11.8 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3529) TOM_sub5 PF15178.1 ESA24046.1 - 0.12 12.0 0.3 4.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM5 homolog LUC7 PF03194.10 ESA24046.1 - 0.37 10.2 5.2 0.2 11.1 2.1 1.7 1 1 1 2 2 2 0 LUC7 N_terminus MHCassoc_trimer PF08831.5 ESA24046.1 - 0.81 9.5 6.1 17 5.3 0.0 3.1 3 1 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain Syntaxin-6_N PF09177.6 ESA24046.1 - 0.85 10.0 5.4 0.81 10.1 0.5 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Orthopox_A5L PF06193.6 ESA24046.1 - 3.1 7.6 8.2 1.3 8.9 0.7 2.2 1 1 1 2 2 2 0 Orthopoxvirus A5L protein-like Pkip-1 PF06878.6 ESA24046.1 - 5.3 6.9 11.4 32 4.3 1.6 2.2 1 1 1 2 2 2 0 Pkip-1 protein DUF1342 PF07072.6 ESA24047.1 - 0.058 13.0 0.2 0.066 12.8 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1342) Snf7 PF03357.16 ESA24048.1 - 3.8 6.8 17.8 12 5.2 12.5 1.5 1 1 0 1 1 1 0 Snf7 DUF4413 PF14372.1 ESA24049.1 - 6e-05 22.9 1.0 0.00012 22.0 0.4 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4413) INCENP_ARK-bind PF03941.10 ESA24050.1 - 0.15 11.8 0.6 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region L51_S25_CI-B8 PF05047.11 ESA24051.1 - 0.036 13.8 0.7 0.077 12.7 0.0 1.9 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HMG_box PF00505.14 ESA24052.1 - 2e-07 31.1 1.0 4.4e-07 30.0 0.3 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA24052.1 - 3.1e-05 24.2 0.5 5.5e-05 23.4 0.2 1.6 1 1 0 1 1 1 1 HMG-box domain Ribosomal_L18_c PF14204.1 ESA24052.1 - 0.44 11.1 0.0 0.44 11.1 0.0 2.4 2 1 0 2 2 2 0 Ribosomal L18 C-terminal region NUDE_C PF04880.8 ESA24052.1 - 0.99 9.7 10.4 87 3.4 7.2 2.2 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region Fip1 PF05182.8 ESA24052.1 - 4.5 6.6 7.2 0.28 10.5 0.9 2.0 2 0 0 2 2 2 0 Fip1 motif DUF1542 PF07564.6 ESA24053.1 - 0.0076 16.2 1.5 0.018 15.0 1.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1542) zf-B_box PF00643.19 ESA24053.1 - 0.24 11.3 4.9 0.41 10.5 3.4 1.3 1 0 0 1 1 1 0 B-box zinc finger Cys_Met_Meta_PP PF01053.15 ESA24055.1 - 0.00042 18.7 0.1 0.00042 18.7 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Sel1 PF08238.7 ESA24057.1 - 2e-62 206.2 37.4 1.4e-11 44.6 0.1 9.4 9 1 0 9 9 9 8 Sel1 repeat TPR_12 PF13424.1 ESA24057.1 - 3.4e-07 30.1 12.5 0.00032 20.5 1.3 5.9 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 ESA24057.1 - 0.0016 18.1 7.8 0.51 10.2 0.0 5.2 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 ESA24057.1 - 0.0032 17.8 17.2 12 6.6 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 ESA24057.1 - 0.1 12.2 30.8 0.077 12.6 2.1 5.3 3 2 2 6 6 6 0 TPR repeat MIT PF04212.13 ESA24057.1 - 0.13 12.1 22.4 2 8.3 0.2 6.3 4 3 1 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.1 ESA24057.1 - 0.64 9.9 0.1 0.64 9.9 0.1 7.8 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.23 ESA24057.1 - 2.9 7.6 29.8 4.2 7.1 0.0 8.3 7 1 0 7 7 7 0 Tetratricopeptide repeat NSF PF02071.15 ESA24057.1 - 9.2 7.3 8.3 8.8 7.4 0.2 4.8 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat DUF3479 PF11965.3 ESA24059.1 - 0.018 14.8 1.3 0.018 14.8 0.9 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3479) DUF4613 PF15390.1 ESA24059.1 - 0.076 11.1 9.1 0.081 11.0 6.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) PilJ PF13675.1 ESA24059.1 - 0.12 12.7 10.6 0.42 10.9 1.5 2.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3584 PF12128.3 ESA24059.1 - 0.2 8.9 24.3 0.22 8.8 16.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Microtub_assoc PF07989.6 ESA24059.1 - 0.73 9.7 25.0 2 8.2 4.1 3.3 1 1 0 2 2 2 0 Microtubule associated DPM3 PF08285.6 ESA24059.1 - 0.84 9.5 6.7 2 8.3 0.4 2.7 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) TPR_MLP1_2 PF07926.7 ESA24059.1 - 1.7 8.3 34.1 0.48 10.1 8.4 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NYD-SP28_assoc PF14775.1 ESA24059.1 - 2.2 8.0 20.1 4.2 7.1 1.1 3.9 2 1 1 3 3 3 0 Sperm tail C-terminal domain SprA-related PF12118.3 ESA24059.1 - 4.2 6.6 21.4 4.8 6.4 14.9 1.1 1 0 0 1 1 1 0 SprA-related family Mitofilin PF09731.4 ESA24059.1 - 4.9 5.6 27.0 6.5 5.2 18.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SMN PF06003.7 ESA24060.1 - 0.026 13.6 0.1 0.03 13.4 0.0 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Ste5_C PF12194.3 ESA24061.1 - 0.034 13.7 0.1 0.04 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein kinase Fus3-binding TRP_2 PF08344.6 ESA24061.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Transient receptor ion channel II HR1 PF02185.11 ESA24062.1 - 0.032 13.9 1.6 0.091 12.5 1.1 1.7 1 0 0 1 1 1 0 Hr1 repeat DUF2283 PF10049.4 ESA24063.1 - 4.7e-09 35.9 1.1 2.3e-07 30.5 0.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2283) DUF3641 PF12345.3 ESA24063.1 - 0.0047 16.7 0.3 0.0079 16.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3641) TFX_C PF14601.1 ESA24063.1 - 0.12 12.1 0.1 5.9 6.7 0.0 2.6 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term S-layer PF07752.6 ESA24063.1 - 0.69 9.0 4.7 6.4 5.9 0.0 2.6 2 1 0 2 2 2 0 S-layer protein zf-CpG_bind_C PF12269.3 ESA24064.1 - 0.067 12.6 0.1 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Rootletin PF15035.1 ESA24065.1 - 0.0012 18.9 2.2 0.0014 18.6 1.5 1.1 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion AKNA PF12443.3 ESA24065.1 - 0.0022 17.9 0.9 0.0029 17.6 0.6 1.2 1 0 0 1 1 1 1 AT-hook-containing transcription factor DUF904 PF06005.7 ESA24065.1 - 0.027 14.7 5.2 0.033 14.4 3.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF904) Spond_N PF06468.8 ESA24065.1 - 0.027 14.1 0.0 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 Spondin_N NYD-SP28_assoc PF14775.1 ESA24065.1 - 0.11 12.1 3.0 0.25 11.0 2.1 1.7 1 1 0 1 1 1 0 Sperm tail C-terminal domain Phage_BR0599 PF09356.5 ESA24065.1 - 0.11 12.5 0.2 0.22 11.6 0.0 1.5 2 0 0 2 2 2 0 Phage conserved hypothetical protein BR0599 Syntaxin_2 PF14523.1 ESA24065.1 - 0.17 11.8 6.3 0.25 11.3 4.3 1.5 1 1 0 1 1 1 0 Syntaxin-like protein bZIP_1 PF00170.16 ESA24065.1 - 0.3 11.0 7.8 0.066 13.1 2.5 2.1 2 1 1 3 3 3 0 bZIP transcription factor Ribosomal_L35p PF01632.14 ESA24065.1 - 1.1 9.2 4.2 0.71 9.8 1.5 1.7 2 0 0 2 2 2 0 Ribosomal protein L35 Cep57_CLD_2 PF14197.1 ESA24065.1 - 2.9 7.9 7.2 4.4 7.3 3.4 2.1 1 1 0 2 2 2 0 Centrosome localisation domain of PPC89 bZIP_2 PF07716.10 ESA24065.1 - 3.5 7.5 6.9 0.62 9.9 0.5 2.6 3 0 0 3 3 3 0 Basic region leucine zipper Fez1 PF06818.10 ESA24066.1 - 0.00043 20.3 3.6 0.00043 20.3 2.5 2.1 1 1 1 2 2 2 1 Fez1 Rrn6 PF10214.4 ESA24066.1 - 0.001 17.2 8.4 0.0012 17.0 5.8 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor HrpB7 PF09486.5 ESA24066.1 - 0.0018 18.1 1.3 0.18 11.7 0.0 2.2 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) Snapin_Pallidin PF14712.1 ESA24066.1 - 0.0019 18.4 3.3 0.0019 18.4 2.3 3.1 1 1 2 3 3 3 1 Snapin/Pallidin Cast PF10174.4 ESA24066.1 - 0.0033 15.5 13.4 0.004 15.2 9.0 1.3 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone GAS PF13851.1 ESA24066.1 - 0.0049 16.0 20.9 0.015 14.4 5.7 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 ESA24066.1 - 0.0092 15.1 8.5 0.011 14.8 5.9 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein DUF869 PF05911.6 ESA24066.1 - 0.014 13.7 16.1 0.016 13.4 11.2 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) DUF1436 PF07262.6 ESA24066.1 - 0.015 14.8 1.7 0.015 14.8 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1436) DUF3552 PF12072.3 ESA24066.1 - 0.071 12.3 18.0 0.018 14.2 3.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF4446 PF14584.1 ESA24066.1 - 0.12 12.2 10.1 1.4 8.7 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Hema_stalk PF08720.5 ESA24066.1 - 0.14 11.6 1.0 0.26 10.7 0.1 1.6 1 1 1 2 2 2 0 Influenza C hemagglutinin stalk IncA PF04156.9 ESA24066.1 - 0.2 11.2 22.4 0.21 11.1 4.7 2.1 1 1 1 2 2 2 0 IncA protein Atg14 PF10186.4 ESA24066.1 - 0.29 10.0 14.2 0.44 9.4 9.8 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 XhlA PF10779.4 ESA24066.1 - 0.29 11.0 10.5 0.084 12.8 1.7 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Spc7 PF08317.6 ESA24066.1 - 0.29 9.7 21.0 0.37 9.4 14.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 ESA24066.1 - 0.31 10.8 22.0 0.38 10.6 13.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin_2 PF14523.1 ESA24066.1 - 0.56 10.2 20.6 0.4 10.7 6.8 2.2 1 1 1 2 2 2 0 Syntaxin-like protein DUF4200 PF13863.1 ESA24066.1 - 0.59 10.0 17.2 4.2 7.3 4.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) GreA_GreB_N PF03449.10 ESA24066.1 - 0.79 9.8 4.6 6.7 6.8 0.6 3.5 1 1 2 3 3 2 0 Transcription elongation factor, N-terminal Seryl_tRNA_N PF02403.17 ESA24066.1 - 1.7 8.7 17.8 0.89 9.5 4.3 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.7 ESA24066.1 - 1.8 8.8 11.0 3.7 7.8 1.3 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 ESA24066.1 - 1.9 8.6 17.5 5.2 7.1 9.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF641 PF04859.7 ESA24066.1 - 2.1 8.1 13.7 0.78 9.4 3.5 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ATG16 PF08614.6 ESA24066.1 - 2.2 8.0 20.5 0.57 9.9 4.2 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) NEMO PF11577.3 ESA24066.1 - 2.2 8.0 6.9 5.5 6.8 2.1 2.6 2 1 0 2 2 2 0 NF-kappa-B essential modulator NEMO HR1 PF02185.11 ESA24066.1 - 2.3 8.0 19.4 0.2 11.4 4.5 3.4 1 1 2 3 3 3 0 Hr1 repeat AAA_23 PF13476.1 ESA24066.1 - 2.6 8.3 15.5 3.4 7.9 10.8 1.1 1 0 0 1 1 1 0 AAA domain DUF745 PF05335.8 ESA24066.1 - 4.3 6.8 12.6 1.7 8.1 6.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) UPF0231 PF06062.6 ESA24066.1 - 4.5 7.1 7.1 2.2 8.1 2.6 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0231) DUF1479 PF07350.7 ESA24066.1 - 4.9 5.5 6.6 0.31 9.4 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) SlyX PF04102.7 ESA24066.1 - 6.2 7.2 10.6 22 5.5 1.9 3.1 1 1 1 3 3 3 0 SlyX TSC22 PF01166.13 ESA24066.1 - 6.9 6.7 14.9 3.1 7.8 2.6 4.0 1 1 3 4 4 4 0 TSC-22/dip/bun family DUF724 PF05266.9 ESA24066.1 - 8.9 5.8 16.6 4.8 6.7 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.10 ESA24067.1 - 0.086 12.3 3.9 0.39 10.2 2.7 2.1 1 0 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.1 ESA24067.1 - 0.18 10.7 6.1 0.27 10.1 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LRR_4 PF12799.2 ESA24068.1 - 0.0005 19.6 1.4 0.038 13.6 0.1 3.4 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_2 PF07723.8 ESA24068.1 - 0.00073 19.9 7.0 0.63 10.6 0.0 4.3 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.1 ESA24068.1 - 0.022 14.4 0.4 0.022 14.4 0.3 3.7 3 1 0 4 4 4 0 Leucine rich repeat LRR_7 PF13504.1 ESA24068.1 - 0.058 13.6 5.5 0.67 10.3 0.0 5.0 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 ESA24068.1 - 0.089 12.8 2.8 1.7 8.9 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 ESA24068.1 - 0.61 10.3 5.7 1.9 8.8 0.1 4.2 5 0 0 5 5 5 0 Leucine Rich repeat PWI PF01480.12 ESA24069.1 - 0.00027 20.9 0.0 0.00071 19.6 0.0 1.8 1 0 0 1 1 1 1 PWI domain DUF4646 PF15496.1 ESA24070.1 - 2.6e-12 46.8 0.7 8.9e-11 41.9 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4646) Erf4 PF10256.4 ESA24070.1 - 1.2e-07 31.5 1.2 8.4e-07 28.8 0.2 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family CUE PF02845.11 ESA24070.1 - 0.02 14.3 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 CUE domain DUF760 PF05542.6 ESA24070.1 - 0.027 14.6 0.1 0.059 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF760) CAF-1_p150 PF11600.3 ESA24070.1 - 1.1 8.6 29.1 2.4 7.4 20.2 1.5 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DDRGK PF09756.4 ESA24070.1 - 1.1 8.6 17.2 1.9 7.8 11.9 1.3 1 0 0 1 1 1 0 DDRGK domain Peptidase_S49_N PF08496.5 ESA24070.1 - 4 7.2 8.3 8.4 6.1 5.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Chitin_synth_1 PF01644.12 ESA24071.1 - 1.3e-54 184.4 1.1 4.3e-51 172.9 0.4 2.4 1 1 1 2 2 2 2 Chitin synthase Chitin_synth_1N PF08407.6 ESA24071.1 - 1.9e-29 101.1 0.1 4.3e-29 100.0 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 ESA24071.1 - 5.8e-27 94.2 0.0 4.3e-21 74.9 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.1 ESA24071.1 - 1.5e-10 41.0 0.3 1.5e-10 41.0 0.2 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 ESA24071.1 - 1.1e-06 28.6 0.0 2.5e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 DUF605 PF04652.11 ESA24072.1 - 3.7e-85 286.6 48.1 1.7e-83 281.1 33.3 2.0 1 1 0 1 1 1 1 Vta1 like FNIP_N PF14636.1 ESA24072.1 - 9 6.7 8.6 2.2 8.7 3.3 1.9 1 1 1 2 2 2 0 Folliculin-interacting protein N-terminus Cupin_8 PF13621.1 ESA24073.1 - 2e-20 73.3 0.0 5.1e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 ESA24073.1 - 4e-18 65.7 0.1 1.1e-17 64.2 0.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase CAF-1_p150 PF11600.3 ESA24073.1 - 0.55 9.5 18.5 0.011 15.1 7.5 2.0 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF3146 PF11344.3 ESA24076.1 - 0.076 12.4 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) zf-Dof PF02701.10 ESA24077.1 - 0.12 12.3 0.5 0.21 11.5 0.4 1.4 1 0 0 1 1 1 0 Dof domain, zinc finger DUF4201 PF13870.1 ESA24078.1 - 0.009 15.4 17.6 0.009 15.4 12.2 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) Pentaxin PF00354.12 ESA24078.1 - 0.01 15.2 1.7 0.019 14.3 0.6 1.8 1 1 1 2 2 2 0 Pentaxin family CENP-F_leu_zip PF10473.4 ESA24078.1 - 0.039 13.7 23.6 0.078 12.8 10.2 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 ESA24078.1 - 3.2 8.1 17.9 6.8 7.0 3.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) DUF342 PF03961.8 ESA24078.1 - 4.8 5.4 19.6 60 1.8 13.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Cauli_AT PF03233.8 ESA24078.1 - 4.9 6.8 20.3 3.2 7.4 4.8 2.3 1 1 1 2 2 2 0 Aphid transmission protein Chibby PF14645.1 ESA24079.1 - 0.25 11.2 2.0 9.3 6.1 0.2 2.3 2 0 0 2 2 2 0 Chibby family Sel1 PF08238.7 ESA24080.1 - 2.6e-216 695.3 114.1 1e-12 48.2 0.3 27.1 27 0 0 27 27 27 27 Sel1 repeat TPR_6 PF13174.1 ESA24080.1 - 1.7e-06 28.0 44.0 2.5 8.7 0.0 15.0 18 0 0 18 18 18 5 Tetratricopeptide repeat Sel1 PF08238.7 ESA24081.1 - 7.1e-223 716.2 105.1 1.6e-09 38.0 0.4 30.3 30 0 0 30 30 30 27 Sel1 repeat Pkinase_Tyr PF07714.12 ESA24081.1 - 2.6e-46 157.7 0.0 4.9e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24081.1 - 7.7e-46 156.3 0.1 1.6e-45 155.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain YrbL-PhoP_reg PF10707.4 ESA24081.1 - 0.0012 18.1 0.1 0.003 16.9 0.0 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.9 ESA24081.1 - 0.0071 15.4 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_6 PF13174.1 ESA24081.1 - 5.3 7.7 51.7 1.4 9.5 0.0 16.3 19 1 0 19 19 19 0 Tetratricopeptide repeat Rootletin PF15035.1 ESA24084.1 - 7.6 6.4 21.2 0.084 12.8 7.8 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Cep57_CLD_2 PF14197.1 ESA24084.1 - 8 6.4 21.9 0.039 13.8 7.4 2.9 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Helicase_C PF00271.26 ESA24088.1 - 9.1e-18 63.9 0.1 6.7e-17 61.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 ESA24088.1 - 0.002 17.6 0.0 0.0079 15.6 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4528 PF15031.1 ESA24088.1 - 0.021 14.5 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) ArdA PF07275.6 ESA24092.1 - 0.13 12.5 0.1 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 Antirestriction protein (ArdA) BTB_2 PF02214.17 ESA24093.1 - 1.4e-18 66.8 0.8 5.2e-18 65.0 0.6 1.9 1 1 0 1 1 1 1 BTB/POZ domain DUF2648 PF10855.3 ESA24094.1 - 0.036 13.4 2.0 0.066 12.6 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) Granulin PF00396.13 ESA24094.1 - 1 9.4 19.5 30 4.8 5.6 2.6 1 1 1 2 2 2 0 Granulin Laminin_G_3 PF13385.1 ESA24095.1 - 1.7e-09 38.1 0.1 2e-09 37.8 0.1 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Toxin_R_bind_N PF07953.7 ESA24095.1 - 0.00087 18.8 0.2 0.0019 17.7 0.1 1.5 2 0 0 2 2 2 1 Clostridium neurotoxin, N-terminal receptor binding Laminin_G_3 PF13385.1 ESA24096.1 - 5.9e-11 42.8 0.3 6.8e-11 42.6 0.2 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Toxin_R_bind_N PF07953.7 ESA24096.1 - 0.0023 17.4 0.2 0.0041 16.6 0.1 1.3 1 0 0 1 1 1 1 Clostridium neurotoxin, N-terminal receptor binding Laminin_G_3 PF13385.1 ESA24097.1 - 5.6e-09 36.4 0.1 6.7e-09 36.1 0.1 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Toxin_R_bind_N PF07953.7 ESA24097.1 - 0.007 15.8 0.3 0.013 15.0 0.2 1.4 1 0 0 1 1 1 1 Clostridium neurotoxin, N-terminal receptor binding Laminin_G_3 PF13385.1 ESA24098.1 - 0.1 12.8 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Sel1 PF08238.7 ESA24100.1 - 1.3e-68 225.8 46.2 3.7e-10 40.0 0.2 9.2 10 0 0 10 10 10 8 Sel1 repeat TPR_6 PF13174.1 ESA24100.1 - 9e-07 28.9 12.5 1.1 9.8 0.0 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat DUF2235 PF09994.4 ESA24100.1 - 0.0078 15.6 6.7 0.17 11.2 0.1 3.4 1 1 0 3 3 3 2 Uncharacterized alpha/beta hydrolase domain (DUF2235) Phage_Nu1 PF07471.7 ESA24100.1 - 0.1 12.0 0.2 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 Sel1 PF08238.7 ESA24101.1 - 6.8e-30 102.8 8.6 1.1e-09 38.5 0.1 5.2 5 0 0 5 5 5 4 Sel1 repeat TPR_6 PF13174.1 ESA24101.1 - 0.0017 18.6 7.5 0.85 10.2 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat PhoD PF09423.5 ESA24101.1 - 0.054 12.0 0.1 0.074 11.6 0.1 1.1 1 0 0 1 1 1 0 PhoD-like phosphatase Sel1 PF08238.7 ESA24102.1 - 1.2e-37 127.5 9.6 4.5e-08 33.4 0.1 5.0 5 0 0 5 5 5 5 Sel1 repeat TPR_6 PF13174.1 ESA24102.1 - 0.01 16.2 6.7 22 5.7 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Papo_T_antigen PF02380.10 ESA24102.1 - 0.22 11.4 6.0 13 5.7 0.2 3.3 2 1 2 4 4 4 0 T-antigen specific domain Pkinase PF00069.20 ESA24103.1 - 1.8e-26 92.8 0.3 2e-26 92.7 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24103.1 - 5.9e-24 84.5 0.0 6.4e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 ESA24103.1 - 0.005 16.2 0.2 0.0063 15.8 0.1 1.1 1 0 0 1 1 1 1 RIO1 family WaaY PF06176.6 ESA24103.1 - 0.012 14.8 0.1 0.017 14.3 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kdo PF06293.9 ESA24103.1 - 0.017 14.2 0.1 0.021 13.8 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA24103.1 - 0.019 14.7 0.1 0.028 14.1 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Spo12 PF05032.7 ESA24104.1 - 7.6e-07 28.6 1.2 7.6e-07 28.6 0.8 1.6 2 0 0 2 2 2 1 Spo12 family Protocadherin PF08374.6 ESA24104.1 - 0.16 11.6 1.7 0.16 11.6 1.2 1.2 1 0 0 1 1 1 0 Protocadherin 2OG-FeII_Oxy_2 PF13532.1 ESA24105.1 - 2.1e-15 57.0 0.0 3.1e-15 56.5 0.0 1.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 ESA24105.1 - 2.3e-08 34.2 0.0 3.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mito_carr PF00153.22 ESA24106.1 - 4.2e-74 244.3 1.1 3.6e-28 97.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NYAP_C PF15452.1 ESA24106.1 - 0.0021 17.1 0.4 0.44 9.5 0.1 2.4 2 1 0 2 2 2 2 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Tim17 PF02466.14 ESA24106.1 - 0.0084 16.1 0.1 0.022 14.8 0.1 1.8 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CSD PF00313.17 ESA24107.1 - 1.7e-16 59.7 0.4 3e-16 58.9 0.3 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain Bestrophin PF01062.16 ESA24108.1 - 4.4e-63 212.9 0.0 6.1e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF148 PF02520.12 ESA24109.1 - 0.0083 15.8 0.3 0.013 15.3 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF148 DRP PF06044.7 ESA24109.1 - 0.043 12.8 3.2 0.036 13.0 1.3 1.5 1 1 0 1 1 1 0 Dam-replacing family zf-B_box PF00643.19 ESA24109.1 - 0.21 11.5 4.9 0.41 10.5 3.4 1.5 1 0 0 1 1 1 0 B-box zinc finger DUF1542 PF07564.6 ESA24109.1 - 0.22 11.5 0.4 0.22 11.5 0.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) OrfB_Zn_ribbon PF07282.6 ESA24110.1 - 0.23 11.1 1.7 0.31 10.7 1.2 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain RRM_1 PF00076.17 ESA24111.1 - 8.5e-28 95.7 0.2 1.4e-16 59.8 0.1 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA24111.1 - 7.2e-19 67.5 0.1 3.8e-10 39.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 ESA24111.1 - 1.6e-16 59.8 0.2 2.1e-10 40.2 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA24111.1 - 3.1e-05 23.7 0.1 0.00059 19.6 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif Limkain-b1 PF11608.3 ESA24111.1 - 0.0018 17.9 5.9 0.0034 17.1 0.5 2.5 2 0 0 2 2 2 1 Limkain b1 PRP38_assoc PF12871.2 ESA24114.1 - 0.0041 17.6 24.8 0.0041 17.6 17.2 2.2 2 0 0 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term GMC_oxred_C PF05199.8 ESA24114.1 - 0.14 12.4 0.4 0.22 11.7 0.2 1.5 1 1 0 1 1 1 0 GMC oxidoreductase CAF-1_p150 PF11600.3 ESA24114.1 - 0.78 9.0 28.2 1 8.6 19.5 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Auts2 PF15336.1 ESA24114.1 - 1.4 8.9 4.6 2.5 8.0 3.2 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein Cytadhesin_P30 PF07271.6 ESA24116.1 - 0.45 9.7 5.7 0.57 9.3 4.0 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 Pkinase PF00069.20 ESA24118.1 - 6e-23 81.3 0.1 7.7e-23 80.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24118.1 - 1.7e-18 66.6 0.1 2.1e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DCP1 PF06058.8 ESA24118.1 - 0.041 13.9 0.2 0.071 13.1 0.1 1.3 1 0 0 1 1 1 0 Dcp1-like decapping family DUF3712 PF12505.3 ESA24120.1 - 5.5e-40 136.2 8.2 1.9e-22 79.6 0.1 3.8 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) LEA_2 PF03168.8 ESA24120.1 - 1.2e-06 28.8 3.7 0.14 12.5 0.0 4.4 5 0 0 5 5 5 3 Late embryogenesis abundant protein Hemocyanin_C PF03723.9 ESA24121.1 - 1.4e-29 103.0 0.1 1.9e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Hemocyanin, ig-like domain Hemocyanin_M PF00372.14 ESA24121.1 - 4.6e-22 78.6 0.0 2.2e-21 76.4 0.0 1.9 1 1 0 1 1 1 1 Hemocyanin, copper containing domain Tyrosinase PF00264.15 ESA24121.1 - 0.0028 17.8 8.9 0.015 15.4 6.2 2.2 1 1 0 1 1 1 1 Common central domain of tyrosinase Put_Phosphatase PF06888.7 ESA24121.1 - 0.086 11.9 0.1 13 4.8 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase Pkinase PF00069.20 ESA24122.1 - 1.4e-32 112.8 0.0 2.4e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24122.1 - 2.2e-32 112.1 0.0 3e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AAA PF00004.24 ESA24123.1 - 1.2e-15 57.8 0.5 3.7e-15 56.2 0.0 2.0 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 ESA24123.1 - 1.8e-06 27.0 0.0 3e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.1 ESA24123.1 - 3.5e-06 27.1 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 ESA24123.1 - 1.5e-05 25.1 0.6 0.0071 16.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 ESA24123.1 - 1.9e-05 24.9 0.2 0.00014 22.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 ESA24123.1 - 0.00011 22.2 0.5 0.00038 20.6 0.1 2.1 2 1 0 2 2 1 1 RNA helicase AAA_19 PF13245.1 ESA24123.1 - 0.00016 21.3 0.0 0.00037 20.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 ESA24123.1 - 0.00027 20.6 0.2 0.0017 18.0 0.0 2.4 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 ESA24123.1 - 0.00054 20.7 0.3 0.0016 19.2 0.0 2.0 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.7 ESA24123.1 - 0.0006 18.9 0.0 0.0017 17.4 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Arch_ATPase PF01637.13 ESA24123.1 - 0.00064 19.4 1.1 0.0017 18.1 0.0 2.0 2 1 0 2 2 2 1 Archaeal ATPase TIP49 PF06068.8 ESA24123.1 - 0.0011 17.7 0.0 0.0023 16.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus T2SE PF00437.15 ESA24123.1 - 0.0026 16.7 0.0 0.0034 16.3 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.1 ESA24123.1 - 0.0045 16.8 4.1 0.029 14.2 0.0 2.8 2 1 1 3 3 3 1 AAA domain MMR_HSR1 PF01926.18 ESA24123.1 - 0.0046 16.9 0.1 0.0096 15.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2075 PF09848.4 ESA24123.1 - 0.0049 15.8 0.0 0.0049 15.8 0.0 1.7 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 ESA24123.1 - 0.0069 15.9 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain KAP_NTPase PF07693.9 ESA24123.1 - 0.0072 15.3 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain Gtr1_RagA PF04670.7 ESA24123.1 - 0.0079 15.3 0.1 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_23 PF13476.1 ESA24123.1 - 0.0081 16.5 0.2 0.0081 16.5 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 ESA24123.1 - 0.0084 15.7 0.1 0.0084 15.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.7 ESA24123.1 - 0.009 15.1 0.0 0.018 14.1 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin Bac_DnaA PF00308.13 ESA24123.1 - 0.0092 15.6 0.0 0.031 13.9 0.0 1.9 1 1 0 1 1 1 1 Bacterial dnaA protein KaiC PF06745.8 ESA24123.1 - 0.0098 15.0 0.1 0.024 13.7 0.0 1.6 2 0 0 2 2 2 1 KaiC AAA_11 PF13086.1 ESA24123.1 - 0.014 14.9 0.2 0.047 13.2 0.0 2.0 1 1 1 2 2 2 0 AAA domain MCM PF00493.18 ESA24123.1 - 0.016 14.0 0.1 0.046 12.5 0.0 1.7 1 1 1 2 2 2 0 MCM2/3/5 family ABC_tran PF00005.22 ESA24123.1 - 0.02 15.1 0.5 0.045 14.0 0.1 1.8 2 1 0 2 2 1 0 ABC transporter DUF258 PF03193.11 ESA24123.1 - 0.021 14.0 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 ESA24123.1 - 0.022 14.4 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 ESA24123.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 ESA24123.1 - 0.036 13.4 0.1 0.1 12.0 0.0 1.9 2 1 0 2 2 1 0 IstB-like ATP binding protein ATP_bind_1 PF03029.12 ESA24123.1 - 0.062 12.8 0.0 0.14 11.6 0.0 1.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_21 PF13304.1 ESA24123.1 - 0.062 13.2 0.2 0.062 13.2 0.2 2.3 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 ESA24123.1 - 0.066 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 ESA24123.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 ESA24123.1 - 0.085 12.2 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 ESA24123.1 - 0.092 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 ESA24123.1 - 0.13 11.4 0.0 0.27 10.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Umbravirus_LDM PF04817.7 ESA24123.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family Syntaxin-18_N PF10496.4 ESA24123.1 - 0.73 9.7 5.6 0.37 10.6 1.9 2.0 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Secretin_N_2 PF07655.8 ESA24123.1 - 1 9.7 10.3 5 7.5 6.0 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain VWD PF00094.20 ESA24124.1 - 0.13 12.4 0.3 0.17 12.0 0.2 1.3 1 1 0 1 1 1 0 von Willebrand factor type D domain Sel1 PF08238.7 ESA24128.1 - 2e-09 37.7 0.1 6.5e-09 36.1 0.1 1.9 1 0 0 1 1 1 1 Sel1 repeat Pkinase PF00069.20 ESA24129.1 - 1.2e-08 34.4 0.0 1.3e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24129.1 - 4.3e-08 32.5 0.0 4.7e-08 32.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Phage-tail_1 PF09097.5 ESA24129.1 - 0.097 12.2 0.1 0.1 12.1 0.0 1.1 1 0 0 1 1 1 0 Baseplate structural protein, domain 1 Pkinase_Tyr PF07714.12 ESA24131.1 - 2.9e-43 147.7 0.0 4.1e-43 147.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24131.1 - 2.6e-40 138.2 0.7 6.9e-40 136.8 0.5 1.7 1 1 0 1 1 1 1 Protein kinase domain CUB PF00431.15 ESA24131.1 - 0.026 14.5 4.4 0.53 10.3 0.6 2.6 1 1 1 2 2 2 0 CUB domain Chitin_synth_2 PF03142.10 ESA24132.1 - 8.5e-36 123.4 0.0 1.2e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.23 ESA24132.1 - 1.5e-08 34.2 0.1 1.3e-05 24.8 0.0 2.9 4 0 0 4 4 4 2 Cytochrome b5-like Heme/Steroid binding domain DUF2763 PF10961.3 ESA24132.1 - 0.15 12.4 0.1 0.61 10.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) YopR_core PF09025.5 ESA24133.1 - 0.041 13.8 0.0 0.08 12.9 0.0 1.4 1 0 0 1 1 1 0 YopR Core HeLo PF14479.1 ESA24134.1 - 0.052 13.2 0.0 0.055 13.2 0.0 1.0 1 0 0 1 1 1 0 Prion-inhibition and propagation Helitron_like_N PF14214.1 ESA24136.1 - 2.7e-25 89.1 0.0 3.3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus zf-C2H2 PF00096.21 ESA24140.1 - 0.039 14.2 2.8 0.039 14.2 1.9 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 ESA24140.1 - 0.71 10.3 9.0 0.19 12.1 1.2 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger zf-met2 PF12907.2 ESA24140.1 - 1.9 8.5 5.7 2 8.4 2.8 1.9 2 0 0 2 2 2 0 Zinc-binding FHA PF00498.21 ESA24141.1 - 0.11 12.6 1.2 4.2 7.5 0.1 2.5 2 1 0 2 2 2 0 FHA domain rve PF00665.21 ESA24146.1 - 3.8e-08 33.4 0.1 5.9e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Integrase core domain Ribonuc_red_lgN PF00317.16 ESA24147.1 - 0.11 12.2 4.3 1.3 8.8 0.3 2.2 1 1 1 2 2 2 0 Ribonucleotide reductase, all-alpha domain rve PF00665.21 ESA24148.1 - 4.3e-05 23.6 0.0 8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain Ribosomal_L14 PF00238.14 ESA24148.1 - 0.047 13.4 0.1 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L14p/L23e AAA_17 PF13207.1 ESA24148.1 - 0.16 12.8 0.4 0.51 11.1 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 ESA24148.1 - 0.22 11.0 0.6 0.52 9.8 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.1 ESA24148.1 - 0.4 9.6 2.0 4 6.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain GLTP PF08718.6 ESA24149.1 - 0.049 13.6 0.1 0.05 13.6 0.0 1.1 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) GUB_WAK_bind PF13947.1 ESA24149.1 - 0.13 12.8 0.4 0.16 12.5 0.3 1.2 1 0 0 1 1 1 0 Wall-associated receptor kinase galacturonan-binding Kelch_6 PF13964.1 ESA24150.1 - 2.1e-09 37.1 5.1 0.0029 17.7 0.1 3.5 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.1 ESA24150.1 - 7.6e-09 35.3 0.8 0.0025 17.7 0.0 3.8 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.1 ESA24150.1 - 2.6e-08 33.5 1.3 0.27 11.0 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.1 ESA24150.1 - 5.9e-07 29.4 0.2 0.11 12.6 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.10 ESA24150.1 - 1.2e-06 28.0 0.8 0.15 11.8 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 ESA24150.1 - 0.00048 19.6 1.6 1.7 8.2 0.0 3.5 3 1 0 3 3 3 2 Kelch motif FAR1 PF03101.10 ESA24151.1 - 9.2e-05 22.8 0.2 9.2e-05 22.8 0.2 1.8 2 1 0 2 2 2 1 FAR1 DNA-binding domain SET_assoc PF11767.3 ESA24151.1 - 0.11 11.7 0.9 13 5.2 0.0 2.5 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Zn_Tnp_IS1595 PF12760.2 ESA24151.1 - 0.29 10.9 3.2 4.8 7.0 0.2 2.7 3 0 0 3 3 3 0 Transposase zinc-ribbon domain C1_1 PF00130.17 ESA24151.1 - 0.97 9.2 4.7 8.5 6.1 1.2 2.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ubiquitin PF00240.18 ESA24152.1 - 2.8e-09 36.2 0.1 5.5e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family PARP PF00644.15 ESA24152.1 - 0.00018 20.9 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Rad60-SLD PF11976.3 ESA24152.1 - 0.00029 20.4 0.0 0.00056 19.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF3098 PF11297.3 ESA24152.1 - 0.076 12.7 1.6 0.16 11.6 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) PB1 PF00564.19 ESA24152.1 - 0.077 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 PB1 domain HMG_box PF00505.14 ESA24153.1 - 5.1e-06 26.6 0.6 1.1e-05 25.5 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA24153.1 - 0.00017 21.8 0.4 0.00031 21.0 0.2 1.4 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA24154.1 - 8.3e-17 61.2 3.5 8.3e-17 61.2 2.4 2.6 2 1 1 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 ESA24154.1 - 1.8e-10 40.9 2.2 1.8e-10 40.9 1.5 2.6 2 1 1 3 3 3 1 HMG-box domain Macoilin PF09726.4 ESA24154.1 - 2.2 6.4 22.0 3 6.0 15.3 1.3 1 0 0 1 1 1 0 Transmembrane protein Spindle_Spc25 PF08234.7 ESA24155.1 - 2.7e-19 68.9 0.2 7.1e-19 67.5 0.2 1.8 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Atg14 PF10186.4 ESA24155.1 - 0.0079 15.1 15.5 0.011 14.6 10.7 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 DDE_1 PF03184.14 ESA24156.1 - 1.1e-15 57.3 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 ESA24156.1 - 0.00059 19.6 0.2 0.0011 18.7 0.2 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Ribosomal_L44 PF00935.14 ESA24156.1 - 0.043 13.8 0.2 0.098 12.6 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L44 F-box-like PF12937.2 ESA24157.1 - 0.0056 16.3 3.2 0.019 14.6 2.2 2.0 1 0 0 1 1 1 1 F-box-like NPV_P10 PF05531.7 ESA24157.1 - 0.09 13.0 0.2 1.9 8.7 0.1 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LRR_4 PF12799.2 ESA24157.1 - 0.76 9.4 8.8 1.8 8.2 0.2 4.2 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) DUF262 PF03235.9 ESA24158.1 - 2e-06 27.9 7.9 1.4e-05 25.1 5.5 2.1 1 1 0 1 1 1 1 Protein of unknown function DUF262 DUF106 PF01956.11 ESA24160.1 - 1.1e-44 151.9 0.4 1.4e-44 151.5 0.3 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF106 Rad51 PF08423.6 ESA24161.1 - 5.2e-14 51.7 0.9 3.9e-06 25.9 0.0 2.2 1 1 1 2 2 2 2 Rad51 KaiC PF06745.8 ESA24161.1 - 3e-06 26.5 0.8 6.5e-06 25.4 0.6 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.1 ESA24161.1 - 3.3e-06 26.6 0.7 0.0043 16.4 0.1 2.1 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.10 ESA24161.1 - 0.0023 16.8 0.2 0.22 10.3 0.1 2.6 1 1 1 2 2 2 2 DnaB-like helicase C terminal domain RecA PF00154.16 ESA24161.1 - 0.0058 15.7 0.1 0.035 13.1 0.0 2.0 2 0 0 2 2 2 1 recA bacterial DNA recombination protein PAXNEB PF05625.6 ESA24161.1 - 0.046 12.5 1.7 2.2 7.0 0.0 2.1 1 1 1 2 2 2 0 PAXNEB protein DUF2781 PF10914.3 ESA24162.1 - 2.7e-31 108.3 8.8 3.3e-31 108.0 6.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Pkinase PF00069.20 ESA24163.1 - 1.9e-64 217.3 0.0 2.2e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24163.1 - 1.8e-36 125.5 0.0 2.2e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 ESA24163.1 - 4.1e-08 32.5 0.0 6.2e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 ESA24163.1 - 0.0018 17.3 0.0 0.0032 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 ESA24163.1 - 0.014 15.1 0.2 0.02 14.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 ESA24163.1 - 0.02 13.7 0.4 0.034 12.9 0.2 1.3 1 1 0 1 1 1 0 Poxvirus serine/threonine protein kinase NifZ PF04319.8 ESA24163.1 - 0.12 11.7 0.0 0.29 10.5 0.0 1.6 1 0 0 1 1 1 0 NifZ domain Sel1 PF08238.7 ESA24164.1 - 7.5e-56 185.3 13.7 8.9e-11 42.0 0.5 7.5 7 0 0 7 7 7 7 Sel1 repeat Filamin PF00630.14 ESA24164.1 - 0.0028 18.1 0.1 0.11 13.0 0.0 3.3 1 1 2 3 3 3 1 Filamin/ABP280 repeat AAA_11 PF13086.1 ESA24167.1 - 5e-15 55.7 3.2 7.6e-15 55.1 0.8 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 ESA24167.1 - 6.7e-06 25.7 0.0 1.4e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain DUF2075 PF09848.4 ESA24167.1 - 0.00019 20.5 0.8 0.00038 19.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 ESA24167.1 - 0.00099 19.3 0.0 0.0034 17.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 ESA24167.1 - 0.0091 15.5 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 ESA24167.1 - 0.01 15.6 0.1 0.01 15.6 0.0 2.9 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit AAA_16 PF13191.1 ESA24167.1 - 0.012 15.5 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 ESA24167.1 - 0.014 15.5 0.1 0.061 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2435 PF10363.4 ESA24167.1 - 0.053 13.4 0.1 0.18 11.7 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) DDE_1 PF03184.14 ESA24170.1 - 3.2e-08 32.9 0.0 3.8e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease NTF2 PF02136.15 ESA24171.1 - 5.1e-26 91.3 0.0 1.7e-25 89.6 0.0 2.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.17 ESA24171.1 - 5.1e-12 45.2 0.0 1.4e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA24171.1 - 1.2e-06 28.4 0.0 2.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 ESA24171.1 - 0.00016 21.5 0.0 0.00049 19.9 0.0 1.9 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.1 ESA24171.1 - 0.00037 20.2 0.0 0.00094 18.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 ESA24171.1 - 0.00081 19.1 0.1 0.0021 17.7 0.0 1.8 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF4518 PF15008.1 ESA24171.1 - 0.029 13.4 0.0 0.073 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) DEAD PF00270.24 ESA24172.1 - 5.9e-47 159.2 0.0 1.9e-46 157.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 ESA24172.1 - 1e-27 95.8 0.0 7.1e-26 89.8 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Btz PF09405.5 ESA24173.1 - 1.6e-09 37.8 11.5 1.6e-09 37.8 8.0 3.9 3 1 0 3 3 3 1 CASC3/Barentsz eIF4AIII binding SRP40_C PF05022.7 ESA24174.1 - 4e-26 91.2 2.8 1.4e-25 89.5 2.0 2.0 1 0 0 1 1 1 1 SRP40, C-terminal domain Acetyltransf_1 PF00583.19 ESA24175.1 - 6.5e-14 51.7 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 ESA24175.1 - 4.3e-08 33.2 0.4 1e-07 32.0 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 ESA24175.1 - 0.00078 19.4 0.1 0.0011 18.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 ESA24175.1 - 0.0016 18.6 0.0 0.0019 18.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 ESA24175.1 - 0.0018 18.4 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 ESA24175.1 - 0.0059 16.4 0.0 0.0083 16.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 ESA24175.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein LRR_8 PF13855.1 ESA24176.1 - 2.9e-19 68.5 37.4 3.2e-09 36.3 5.4 2.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 ESA24176.1 - 8.1e-18 63.6 37.7 2.6e-07 30.0 2.4 4.0 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 ESA24176.1 - 4.5e-13 47.2 20.3 0.0062 16.4 0.1 5.2 5 0 0 5 5 5 5 Leucine Rich Repeat LRR_7 PF13504.1 ESA24176.1 - 0.00043 20.0 26.6 0.13 12.5 0.0 5.7 6 0 0 6 6 6 3 Leucine rich repeat LRR_6 PF13516.1 ESA24176.1 - 0.002 17.9 17.9 0.28 11.3 0.1 4.9 4 2 1 5 5 5 3 Leucine Rich repeat Chaperone_III PF07824.7 ESA24176.1 - 0.17 11.7 2.0 11 5.9 0.2 2.6 1 1 2 3 3 3 0 Type III secretion chaperone domain PA28_alpha PF02251.13 ESA24176.1 - 0.19 11.9 5.4 1.4 9.1 0.6 2.6 1 1 2 3 3 3 0 Proteasome activator pa28 alpha subunit DUF1886 PF09171.5 ESA24179.1 - 0.0093 15.0 0.4 0.012 14.6 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1886) RNA_polI_A34 PF08208.6 ESA24180.1 - 0.0036 16.9 0.2 0.0036 16.9 0.1 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 zf-Apc11 PF12861.2 ESA24181.1 - 9.7e-44 147.1 10.7 1.1e-43 146.9 7.4 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 ESA24181.1 - 1.9e-32 111.1 9.7 2.2e-32 110.9 6.7 1.0 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 ESA24181.1 - 4.1e-06 26.5 16.9 2.4e-05 24.0 11.7 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 ESA24181.1 - 0.00012 22.0 3.6 0.00012 22.0 2.5 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 ESA24181.1 - 0.0084 15.7 10.3 0.02 14.5 3.8 2.3 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 ESA24181.1 - 0.016 14.8 11.0 0.065 12.9 7.7 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HIT PF04438.11 ESA24181.1 - 0.026 14.1 4.1 0.048 13.3 2.9 1.4 1 0 0 1 1 1 0 HIT zinc finger zf-RING_5 PF14634.1 ESA24181.1 - 0.16 11.7 13.2 1.7 8.4 9.3 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-Nse PF11789.3 ESA24181.1 - 0.17 11.4 2.4 0.31 10.5 1.7 1.4 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 ESA24181.1 - 0.75 9.5 6.5 0.14 11.8 2.0 1.7 2 1 0 2 2 2 0 RING-type zinc-finger SPRY PF00622.23 ESA24182.1 - 2.5e-18 66.3 0.1 4.3e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.1 ESA24182.1 - 1.1e-10 40.9 8.6 2e-10 40.1 5.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 ESA24182.1 - 0.0025 17.5 9.7 0.0044 16.7 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 ESA24182.1 - 0.0061 16.5 11.5 0.013 15.4 8.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HEAT_2 PF13646.1 ESA24182.1 - 0.12 12.7 0.0 0.54 10.5 0.0 2.0 2 0 0 2 2 2 0 HEAT repeats U-box PF04564.10 ESA24183.1 - 9.1e-25 86.4 0.0 1.6e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain BCL9 PF11502.3 ESA24183.1 - 0.022 14.2 0.2 0.04 13.4 0.1 1.4 1 0 0 1 1 1 0 B-cell lymphoma 9 protein COMPASS-Shg1 PF05205.7 ESA24183.1 - 0.04 14.2 1.1 0.72 10.1 0.0 2.3 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 F_actin_bind PF08919.5 ESA24185.1 - 0.15 11.7 1.8 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 F-actin binding Chordopox_A13L PF05961.6 ESA24185.1 - 3.5 7.6 5.8 5.8 6.9 0.1 3.3 3 0 0 3 3 3 0 Chordopoxvirus A13L protein p450 PF00067.17 ESA24186.1 - 2.6e-38 131.7 0.0 2.8e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FBA_2 PF07735.12 ESA24189.1 - 0.12 12.2 0.2 0.31 10.9 0.1 1.7 1 1 0 1 1 1 0 F-box associated Anemone_cytotox PF06369.7 ESA24190.1 - 6.2e-33 113.6 1.4 8e-33 113.3 0.9 1.1 1 0 0 1 1 1 1 Sea anemone cytotoxic protein BTB PF00651.26 ESA24191.1 - 2.3e-19 69.4 0.0 3.4e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 ESA24191.1 - 0.00012 21.9 1.6 0.0056 16.4 0.1 2.9 4 0 0 4 4 4 2 BTB And C-terminal Kelch Nro1 PF12753.2 ESA24196.1 - 0.065 12.1 2.9 0.076 11.9 2.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 DUF4473 PF14747.1 ESA24196.1 - 0.28 11.4 1.7 6.8 6.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) Equine_IAV_S2 PF06502.6 ESA24198.1 - 0.029 14.2 0.5 0.075 12.9 0.3 1.8 1 1 0 1 1 1 0 Equine infectious anaemia virus S2 protein Dimer_Tnp_hAT PF05699.9 ESA24199.1 - 3.2e-15 55.5 0.2 3.5e-15 55.4 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Thg1 PF04446.7 ESA24201.1 - 0.12 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 tRNAHis guanylyltransferase Asp_protease PF09668.5 ESA24202.1 - 0.0088 15.6 0.0 0.022 14.2 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Lzipper-MIP1 PF14389.1 ESA24202.1 - 1.2 9.2 11.3 1.9 8.6 3.0 3.1 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Tropomyosin_1 PF12718.2 ESA24202.1 - 2.4 8.0 15.0 0.55 10.0 0.9 2.8 2 1 0 3 3 3 0 Tropomyosin like DASH_Hsk3 PF08227.6 ESA24202.1 - 3.4 7.9 8.6 17 5.6 0.2 3.8 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like Enkurin PF13864.1 ESA24202.1 - 6.3 7.0 10.7 7.3 6.8 0.9 3.5 3 1 0 4 4 4 0 Calmodulin-binding DUF3573 PF12097.3 ESA24202.1 - 9.1 4.7 8.5 1.6 7.2 3.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Ion_trans PF00520.26 ESA24203.1 - 1.6e-06 27.4 8.4 1.6e-06 27.4 5.8 2.4 2 1 0 3 3 3 1 Ion transport protein DivIC PF04977.10 ESA24203.1 - 0.0041 16.5 0.5 0.018 14.4 0.3 2.2 1 0 0 1 1 1 1 Septum formation initiator TSC22 PF01166.13 ESA24203.1 - 1.6 8.7 7.9 0.19 11.7 1.4 2.4 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF4131 PF13567.1 ESA24203.1 - 1.8 7.9 5.6 0.86 8.9 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Phage_RpbA PF10789.4 ESA24204.1 - 0.017 14.9 0.5 0.062 13.1 0.3 1.9 1 1 0 1 1 1 0 Phage RNA polymerase binding, RpbA YqhG PF11079.3 ESA24204.1 - 0.031 13.1 0.1 0.035 12.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function Gemini_BL1 PF00845.14 ESA24204.1 - 0.042 13.2 0.1 0.047 13.0 0.1 1.2 1 0 0 1 1 1 0 Geminivirus BL1 movement protein FAM194 PF14977.1 ESA24204.1 - 0.049 12.6 0.4 0.057 12.4 0.3 1.1 1 0 0 1 1 1 0 FAM194 protein DUF4080 PF13311.1 ESA24204.1 - 0.11 12.5 0.2 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) FAD_binding_3 PF01494.14 ESA24206.1 - 1.3e-15 57.3 0.1 6e-10 38.7 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_9 PF13454.1 ESA24206.1 - 0.00013 21.7 0.0 0.00067 19.4 0.0 2.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA24206.1 - 0.00035 20.6 0.0 0.0008 19.5 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA24206.1 - 0.00044 20.2 0.0 0.0019 18.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Piwi PF02171.12 ESA24207.1 - 1.1e-95 320.1 0.0 1.6e-95 319.5 0.0 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 ESA24207.1 - 1.3e-24 86.0 1.3 2.8e-24 84.9 0.9 1.5 1 0 0 1 1 1 1 PAZ domain DUF1785 PF08699.5 ESA24207.1 - 1.1e-17 63.1 0.0 5.2e-17 60.9 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1785) DOPA_dioxygen PF08883.6 ESA24208.1 - 1.4e-25 89.3 0.3 1.7e-25 89.0 0.2 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family DUF3596 PF12167.3 ESA24208.1 - 0.06 12.8 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3596) F-box-like PF12937.2 ESA24211.1 - 9.5e-05 22.0 0.2 0.00025 20.6 0.2 1.7 1 0 0 1 1 1 1 F-box-like TSC22 PF01166.13 ESA24213.1 - 0.019 14.9 0.6 0.028 14.3 0.1 1.5 2 0 0 2 2 2 0 TSC-22/dip/bun family CDC45 PF02724.9 ESA24214.1 - 0.082 10.9 1.6 0.11 10.5 1.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.4 ESA24214.1 - 6.2 5.4 11.3 8.7 4.9 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Jiraiya PF15038.1 ESA24215.1 - 0.0072 15.7 6.7 0.042 13.2 0.8 2.4 2 0 0 2 2 2 2 Jiraiya PDR_CDR PF06422.7 ESA24215.1 - 0.044 13.4 4.2 0.2 11.3 0.0 3.1 3 0 0 3 3 3 0 CDR ABC transporter SIT PF15330.1 ESA24215.1 - 1 9.5 8.6 1.8 8.7 0.1 3.2 3 1 1 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT Rab5ip PF07019.7 ESA24215.1 - 1.8 8.7 7.3 11 6.1 0.1 3.4 3 0 0 3 3 3 0 Rab5-interacting protein (Rab5ip) zf-DHHC PF01529.15 ESA24215.1 - 4.1 6.7 13.5 9.7 5.5 3.9 2.7 2 1 0 2 2 2 0 DHHC palmitoyltransferase SLAC1 PF03595.12 ESA24215.1 - 4.3 5.8 14.6 0.19 10.3 4.2 2.0 2 0 0 2 2 2 0 Voltage-dependent anion channel Ninjurin PF04923.7 ESA24215.1 - 9.7 5.9 11.1 3.2 7.5 0.2 3.3 1 1 2 3 3 3 0 Ninjurin DUF3827 PF12877.2 ESA24216.1 - 2.2 6.2 8.2 2.2 6.2 5.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF4544 PF15077.1 ESA24216.1 - 4.2 6.7 5.9 1.2 8.6 0.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4544) Phospholamban PF04272.9 ESA24217.1 - 3.2 7.2 6.7 0.21 11.0 1.1 1.9 2 1 0 2 2 2 0 Phospholamban EST1_DNA_bind PF10373.4 ESA24218.1 - 6.8e-54 182.9 4.7 6.8e-54 182.9 3.3 2.0 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain EST1 PF10374.4 ESA24218.1 - 2.1e-22 79.5 0.7 2.1e-22 79.5 0.5 2.8 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_11 PF13414.1 ESA24218.1 - 1.7e-05 24.4 0.0 4.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 TPR repeat Pkinase_Tyr PF07714.12 ESA24219.1 - 1.9e-06 27.1 0.0 3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24219.1 - 9.3e-05 21.6 0.2 0.00022 20.4 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Aminotran_1_2 PF00155.16 ESA24222.1 - 2.4e-30 105.7 0.0 3e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 ESA24222.1 - 0.069 11.4 0.0 0.1 10.8 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Herpes_PAP PF03325.8 ESA24223.1 - 0.32 10.4 1.5 0.42 10.1 0.3 1.6 1 1 1 2 2 2 0 Herpesvirus polymerase accessory protein Syntaxin PF00804.20 ESA24224.1 - 0.0097 16.0 0.0 0.022 14.9 0.0 1.6 1 1 0 1 1 1 1 Syntaxin Imm35 PF15581.1 ESA24224.1 - 0.015 15.3 0.6 0.03 14.3 0.1 1.7 2 0 0 2 2 2 0 Immunity protein 35 DUF334 PF03904.8 ESA24224.1 - 0.11 11.8 1.1 3.2 6.9 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF334) FlxA PF14282.1 ESA24224.1 - 2.3 8.2 4.6 22 5.0 0.0 2.2 2 0 0 2 2 2 0 FlxA-like protein Pkinase PF00069.20 ESA24225.1 - 4.8e-42 143.9 0.2 1.3e-41 142.4 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24225.1 - 2.9e-41 141.2 0.0 5.4e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.7 ESA24225.1 - 4.4e-32 109.7 12.8 7.7e-07 29.5 0.1 6.5 6 0 0 6 6 6 6 Sel1 repeat Kinase-like PF14531.1 ESA24225.1 - 0.0022 17.0 0.0 1.6 7.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 ESA24225.1 - 0.0029 16.6 0.1 0.0072 15.4 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_6 PF13174.1 ESA24225.1 - 0.0068 16.8 3.4 30 5.3 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat APH PF01636.18 ESA24225.1 - 0.011 15.4 0.2 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NSF PF02071.15 ESA24225.1 - 0.64 10.8 3.8 13 6.8 0.5 3.6 2 0 0 2 2 2 0 Aromatic-di-Alanine (AdAR) repeat YokU PF14122.1 ESA24227.1 - 0.052 13.2 0.2 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 YokU-like protein DUF1877 PF08974.5 ESA24228.1 - 0.11 12.1 0.1 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) DUF3169 PF11368.3 ESA24229.1 - 0.027 13.6 0.4 0.039 13.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) RRM_2 PF04059.7 ESA24230.1 - 3.3e-41 139.1 0.3 3.9e-41 138.9 0.2 1.1 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.17 ESA24230.1 - 0.0093 15.5 0.1 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 ESA24230.1 - 0.059 13.3 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) HMG_box_2 PF09011.5 ESA24233.1 - 0.0067 16.7 0.3 0.01 16.2 0.2 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.14 ESA24233.1 - 0.013 15.7 0.5 0.02 15.1 0.3 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box adh_short PF00106.20 ESA24236.1 - 4.3e-25 88.5 0.0 6.2e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 ESA24236.1 - 1.1e-13 51.5 0.0 1.5e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 ESA24236.1 - 2.1e-09 37.3 0.0 3.3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 ESA24236.1 - 0.051 12.7 0.0 0.091 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) BTB PF00651.26 ESA24237.1 - 3.2e-19 68.9 0.1 4.3e-19 68.5 0.1 1.2 1 0 0 1 1 1 1 BTB/POZ domain DUF1049 PF06305.6 ESA24240.1 - 0.0034 16.8 0.1 0.01 15.3 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1049) BRI3BP PF14965.1 ESA24240.1 - 0.2 10.9 2.6 0.37 10.1 1.8 1.4 1 0 0 1 1 1 0 Negative regulator of p53/TP53 YbjM PF11045.3 ESA24240.1 - 1.3 8.8 4.7 0.27 10.9 0.6 1.8 2 0 0 2 2 2 0 Putative inner membrane protein of Enterobacteriaceae DUF2583 PF10762.4 ESA24240.1 - 7.6 6.7 6.7 3.1 7.9 1.6 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2583) Tim44 PF04280.10 ESA24241.1 - 4.3e-17 62.4 0.0 7e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.6 ESA24241.1 - 3.5e-13 48.9 1.4 4.6e-13 48.5 1.0 1.3 1 0 0 1 1 1 1 MBA1-like protein DUF2636 PF11120.3 ESA24242.1 - 0.011 15.1 0.1 0.54 9.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2636) Exo5 PF09810.4 ESA24243.1 - 2.5e-75 253.7 0.1 3.1e-75 253.3 0.1 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.2 ESA24243.1 - 2.5e-06 27.0 2.6 9.4e-05 21.9 1.8 2.7 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF1374 PF07118.6 ESA24243.1 - 0.021 14.8 2.0 0.056 13.5 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) MBOAT PF03062.14 ESA24244.1 - 1.3e-46 159.1 13.4 2.7e-46 158.1 9.3 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family CTP_transf_2 PF01467.21 ESA24245.1 - 4.1e-19 69.1 0.1 7.2e-19 68.3 0.1 1.4 1 0 0 1 1 1 1 Cytidylyltransferase WD40 PF00400.27 ESA24246.1 - 5.5e-87 282.8 42.9 3.8e-15 55.1 0.2 11.6 12 0 0 12 12 12 8 WD domain, G-beta repeat Pkinase_Tyr PF07714.12 ESA24246.1 - 1.2e-35 122.9 0.1 1.9e-31 109.1 0.0 3.8 3 1 0 3 3 3 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24246.1 - 9.7e-30 103.5 0.1 1.8e-26 92.8 0.1 3.5 2 1 0 2 2 2 1 Protein kinase domain Sel1 PF08238.7 ESA24246.1 - 1.5e-13 50.8 1.1 3.8e-08 33.7 0.0 3.7 4 0 0 4 4 4 2 Sel1 repeat eIF2A PF08662.6 ESA24246.1 - 2.1e-13 50.4 5.2 0.00012 21.9 0.0 4.7 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Pentapeptide PF00805.17 ESA24246.1 - 2e-09 36.4 0.0 3.8e-07 29.2 0.0 2.5 1 1 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 ESA24246.1 - 2.4e-07 30.4 0.0 6.2e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.7 ESA24246.1 - 2.3e-05 23.9 2.1 0.12 12.1 0.0 5.6 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.1 ESA24246.1 - 5.2e-05 23.0 0.0 0.00042 20.1 0.0 2.5 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) APH PF01636.18 ESA24246.1 - 0.0056 16.4 0.7 0.018 14.8 0.5 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 ESA24246.1 - 0.012 14.9 0.4 0.028 13.7 0.1 1.7 2 0 0 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.4 ESA24246.1 - 0.014 14.7 0.0 0.034 13.4 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Proteasome_A_N PF10584.4 ESA24246.1 - 0.038 13.3 2.9 18 4.7 0.0 4.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature NSF PF02071.15 ESA24246.1 - 0.49 11.1 2.0 18 6.4 0.1 3.1 2 0 0 2 2 2 0 Aromatic-di-Alanine (AdAR) repeat DUF1103 PF06513.6 ESA24246.1 - 0.57 9.5 4.6 0.41 10.0 0.3 2.3 2 0 0 2 2 2 0 Repeat of unknown function (DUF1103) MIF4G PF02854.14 ESA24248.1 - 4.8e-42 143.7 10.0 1.1e-28 100.0 0.3 4.7 3 1 1 4 4 4 4 MIF4G domain DIM1 PF02966.11 ESA24249.1 - 7.3e-70 232.6 0.1 8.2e-70 232.4 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 ESA24249.1 - 2.9e-05 23.7 0.0 3.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 ESA24249.1 - 0.015 15.4 0.1 0.021 14.9 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.1 ESA24249.1 - 0.015 15.2 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.1 ESA24249.1 - 0.12 12.6 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain AIG1 PF04548.11 ESA24250.1 - 2e-14 53.2 6.9 3.6e-14 52.3 4.8 1.5 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 ESA24250.1 - 3.3e-09 36.7 1.5 5e-09 36.1 0.4 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 ESA24250.1 - 4.4e-06 27.0 2.0 3.1e-05 24.3 1.4 2.3 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 ESA24250.1 - 6.6e-05 23.0 0.2 0.00045 20.3 0.0 2.0 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.13 ESA24250.1 - 0.0001 21.6 0.5 0.00014 21.1 0.3 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.17 ESA24250.1 - 0.00052 19.4 1.4 0.00066 19.1 0.2 1.7 2 0 0 2 2 2 1 Ras family T2SE PF00437.15 ESA24250.1 - 0.0009 18.2 0.4 0.0021 16.9 0.2 1.7 1 1 1 2 2 2 1 Type II/IV secretion system protein DUF258 PF03193.11 ESA24250.1 - 0.0012 18.0 0.3 0.0035 16.5 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 ESA24250.1 - 0.0015 18.0 0.2 0.0017 17.8 0.1 1.5 1 1 0 1 1 1 1 AAA-like domain Septin PF00735.13 ESA24250.1 - 0.0049 15.9 0.7 0.0049 15.9 0.5 1.7 2 0 0 2 2 2 1 Septin PduV-EutP PF10662.4 ESA24250.1 - 0.014 14.9 0.0 0.035 13.5 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 ESA24250.1 - 0.021 15.6 1.0 0.15 12.9 0.1 2.2 1 1 0 2 2 2 0 AAA domain Miro PF08477.8 ESA24250.1 - 0.03 14.8 0.7 0.066 13.7 0.2 1.9 1 1 0 1 1 1 0 Miro-like protein AAA_28 PF13521.1 ESA24250.1 - 0.044 13.7 0.2 0.48 10.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 ESA24250.1 - 0.097 12.1 0.1 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 ESA24250.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.1 ESA24250.1 - 0.44 10.8 3.5 0.36 11.1 0.3 2.2 1 1 1 2 2 2 0 AAA domain TLD PF07534.11 ESA24251.1 - 4.4e-05 23.5 2.0 5.1e-05 23.2 1.4 1.1 1 0 0 1 1 1 1 TLD DDE_3 PF13358.1 ESA24253.1 - 0.00013 21.7 0.1 0.00043 20.0 0.0 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease SprA-related PF12118.3 ESA24254.1 - 0.0035 16.7 13.1 0.0045 16.3 9.1 1.3 1 0 0 1 1 1 1 SprA-related family Ycf1 PF05758.7 ESA24254.1 - 0.052 11.2 19.8 0.0099 13.6 11.3 1.5 1 1 0 1 1 1 0 Ycf1 Herpes_LMP2 PF07415.6 ESA24254.1 - 1.6 7.2 7.1 2.5 6.6 4.9 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Asp-B-Hydro_N PF05279.6 ESA24254.1 - 6.3 6.5 24.6 13 5.5 17.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Med3 PF11593.3 ESA24255.1 - 0.0055 16.0 6.4 0.0071 15.6 0.6 2.3 2 0 0 2 2 2 1 Mediator complex subunit 3 fungal T4SS PF07996.6 ESA24255.1 - 0.007 16.2 1.9 0.007 16.2 1.3 2.1 2 1 0 2 2 2 1 Type IV secretion system proteins HAUS2 PF15003.1 ESA24255.1 - 0.093 11.7 3.3 0.72 8.8 0.4 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 NPV_P10 PF05531.7 ESA24255.1 - 0.1 12.8 15.3 1.7 8.9 0.4 4.2 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF869 PF05911.6 ESA24255.1 - 0.4 8.8 10.0 0.35 9.0 2.5 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF869) DUF1049 PF06305.6 ESA24255.1 - 2 7.9 3.9 1.4 8.4 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1049) YtxH PF12732.2 ESA24255.1 - 3.9 7.9 6.7 4.8 7.6 0.2 3.3 4 0 0 4 4 4 0 YtxH-like protein DUF1319 PF07028.6 ESA24255.1 - 9.7 6.4 14.1 0.74 10.0 1.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1319) Ecl1 PF12855.2 ESA24256.1 - 0.01 15.1 0.9 0.02 14.1 0.6 1.4 1 0 0 1 1 1 0 Life-span regulatory factor PPPI_inhib PF14895.1 ESA24256.1 - 0.024 13.3 0.3 0.043 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein phosphatase 1 inhibitor zf-GRF PF06839.7 ESA24257.1 - 1.8e-08 34.1 4.0 4e-08 33.0 2.7 1.6 1 0 0 1 1 1 1 GRF zinc finger DegS PF05384.6 ESA24257.1 - 0.0047 16.1 5.3 0.0047 16.1 3.7 2.3 2 1 1 3 3 3 2 Sensor protein DegS Filament PF00038.16 ESA24257.1 - 0.0072 15.8 9.6 0.0072 15.8 6.6 1.6 2 0 0 2 2 2 1 Intermediate filament protein WEMBL PF05701.6 ESA24257.1 - 0.07 11.5 10.5 0.11 10.9 7.3 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light IncA PF04156.9 ESA24257.1 - 0.22 11.0 15.6 0.47 10.0 10.8 1.7 1 1 0 1 1 1 0 IncA protein Rootletin PF15035.1 ESA24257.1 - 0.4 10.6 16.0 0.098 12.6 8.5 1.8 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Sec20 PF03908.8 ESA24257.1 - 1.4 8.6 7.0 0.35 10.6 0.9 2.5 2 1 1 3 3 3 0 Sec20 KxDL PF10241.4 ESA24257.1 - 4.2 7.3 9.9 15 5.5 4.0 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein XkdW PF09636.5 ESA24257.1 - 4.5 7.2 7.6 1.3 8.9 0.3 2.6 1 1 1 2 2 2 0 XkdW protein V_ATPase_I PF01496.14 ESA24257.1 - 5.8 4.6 8.1 7.3 4.3 5.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DMPK_coil PF08826.5 ESA24257.1 - 8 6.4 13.0 2.2 8.2 4.8 2.5 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF3669 PF12417.3 ESA24258.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Zinc finger protein FAD_binding_3 PF01494.14 ESA24259.1 - 7.6e-14 51.5 0.0 7.6e-08 31.7 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_9 PF13454.1 ESA24259.1 - 8.2e-05 22.4 0.0 0.00017 21.3 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 ESA24259.1 - 0.00063 19.8 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 ESA24259.1 - 0.00087 19.2 0.0 0.0031 17.4 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 ESA24259.1 - 0.085 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 ESA24259.1 - 0.087 12.6 0.0 0.12 12.2 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_C PF05199.8 ESA24260.1 - 1.4e-35 122.7 0.0 1.8e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.14 ESA24260.1 - 5.8e-06 25.6 0.0 9.7e-06 24.9 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DUF1965 PF09248.5 ESA24260.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1965) AA_permease_N PF08403.5 ESA24260.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Amino acid permease N-terminal CASP_C PF08172.7 ESA24262.1 - 0.021 13.8 0.3 0.022 13.7 0.2 1.1 1 0 0 1 1 1 0 CASP C terminal U1snRNP70_N PF12220.3 ESA24262.1 - 0.032 14.5 1.5 0.11 12.8 1.1 1.8 1 1 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Sec62 PF03839.11 ESA24262.1 - 0.17 11.2 0.1 0.17 11.2 0.1 1.7 2 0 0 2 2 2 0 Translocation protein Sec62 DUF2740 PF10872.3 ESA24262.1 - 0.27 10.9 2.0 0.51 10.0 1.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2740) DUF4643 PF15485.1 ESA24263.1 - 0.09 12.2 4.4 0.11 11.9 3.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4643) FAM117 PF15388.1 ESA24263.1 - 0.3 10.2 4.2 0.33 10.1 2.9 1.0 1 0 0 1 1 1 0 Protein Family FAM117 DUF2464 PF10240.4 ESA24263.1 - 0.34 10.2 2.4 0.37 10.0 1.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2464) Lamp PF01299.12 ESA24263.1 - 0.38 9.8 3.1 0.42 9.7 2.2 1.0 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) Sporozoite_P67 PF05642.6 ESA24263.1 - 9.1 3.9 9.2 9.5 3.9 6.4 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase_Tyr PF07714.12 ESA24268.1 - 9.8e-41 139.5 0.0 1.2e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24268.1 - 4.3e-38 130.9 0.4 5.1e-38 130.7 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 ESA24268.1 - 0.0023 16.9 0.0 0.0028 16.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 ESA24268.1 - 0.0029 17.3 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 ESA24268.1 - 0.005 15.9 0.3 0.0088 15.1 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 ESA24268.1 - 0.017 14.4 0.2 0.028 13.7 0.2 1.3 1 0 0 1 1 1 0 RIO1 family ARL2_Bind_BART PF11527.3 ESA24269.1 - 0.13 12.0 2.3 0.16 11.7 1.4 1.3 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART DDE_1 PF03184.14 ESA24270.1 - 7.5e-25 87.3 0.5 9.3e-25 87.0 0.3 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Endotoxin_mid PF09131.5 ESA24271.1 - 0.041 13.3 0.3 0.071 12.5 0.2 1.3 1 0 0 1 1 1 0 Bacillus thuringiensis delta-Endotoxin, middle domain Baculo_LEF-11 PF06385.7 ESA24271.1 - 0.39 10.8 2.9 1 9.5 0.2 2.2 2 0 0 2 2 2 0 Baculovirus LEF-11 protein NOT2_3_5 PF04153.13 ESA24272.1 - 0.057 13.3 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family CENP-B_N PF04218.8 ESA24273.1 - 4.2e-08 32.4 1.3 8.8e-08 31.4 0.9 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.11 ESA24273.1 - 7.9e-05 22.3 0.2 0.0056 16.4 0.0 2.5 1 1 1 2 2 2 2 Tc5 transposase DNA-binding domain DDE_1 PF03184.14 ESA24273.1 - 0.00087 18.4 0.0 0.013 14.6 0.0 2.2 2 0 0 2 2 2 1 DDE superfamily endonuclease AAA_18 PF13238.1 ESA24273.1 - 0.06 13.6 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3546 PF12066.3 ESA24277.1 - 0.0035 17.3 0.2 0.0038 17.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) Pox_polyA_pol_N PF12630.2 ESA24277.1 - 0.047 13.7 0.0 0.047 13.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain IQ PF00612.22 ESA24278.1 - 0.0073 15.8 0.4 0.0073 15.8 0.3 1.7 2 0 0 2 2 2 1 IQ calmodulin-binding motif IF2_N PF04760.10 ESA24278.1 - 0.025 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region CRAL_TRIO PF00650.15 ESA24279.1 - 4e-24 84.9 0.1 1.1e-23 83.4 0.0 1.7 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 ESA24279.1 - 0.024 14.5 0.0 0.079 12.8 0.0 1.9 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 ESA24279.1 - 0.08 13.0 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 CRAL/TRIO, N-terminal domain SGS PF05002.10 ESA24280.1 - 1.4e-30 104.9 2.6 4.6e-30 103.1 1.8 2.0 1 0 0 1 1 1 1 SGS domain CS PF04969.11 ESA24280.1 - 4.6e-19 68.7 4.0 8e-19 67.9 2.7 1.4 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 ESA24280.1 - 9.7e-18 63.5 11.1 1.5e-13 50.1 3.4 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 ESA24280.1 - 3.2e-13 48.4 10.9 2.4e-05 23.8 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 ESA24280.1 - 3.7e-11 42.1 12.6 5.3e-06 25.8 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 ESA24280.1 - 1.6e-07 31.1 7.0 0.0011 18.8 0.7 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 ESA24280.1 - 2.4e-06 27.7 10.6 0.0023 18.2 0.6 3.3 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 ESA24280.1 - 7.1e-06 25.4 13.4 0.0021 17.7 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 ESA24280.1 - 2.9e-05 24.2 2.0 0.37 11.3 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 ESA24280.1 - 3e-05 24.2 0.9 0.28 11.9 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 ESA24280.1 - 0.00016 22.2 5.4 0.094 13.4 1.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 ESA24280.1 - 0.00093 19.2 0.8 0.44 10.8 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 ESA24280.1 - 0.0049 16.9 3.8 0.013 15.6 2.3 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 SusD-like_3 PF14322.1 ESA24280.1 - 0.074 13.1 2.5 0.22 11.5 0.6 2.3 2 1 0 2 2 2 0 Starch-binding associating with outer membrane TPR_9 PF13371.1 ESA24280.1 - 0.085 12.7 0.0 1.3 8.9 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 ESA24280.1 - 0.11 12.3 2.4 1.3 8.9 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3856 PF12968.2 ESA24280.1 - 0.13 12.1 3.3 1.8 8.3 1.0 2.9 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) Alkyl_sulf_dimr PF14863.1 ESA24280.1 - 0.15 12.3 0.3 0.15 12.3 0.2 2.3 2 1 1 3 3 3 0 Alkyl sulfatase dimerisation TPR_10 PF13374.1 ESA24280.1 - 0.19 11.7 0.4 20 5.2 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat tRNA-synt_2 PF00152.15 ESA24281.1 - 1.3e-74 251.0 0.1 1.8e-74 250.5 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 ESA24281.1 - 3.8e-09 36.2 0.9 8.1e-09 35.2 0.6 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 ESA24281.1 - 0.012 14.7 0.0 0.42 9.7 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 ESA24281.1 - 0.097 12.2 0.6 0.42 10.1 0.1 2.2 2 1 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) Memo PF01875.12 ESA24282.1 - 1.5e-21 76.5 0.0 1.6e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein NOB1_Zn_bind PF08772.6 ESA24283.1 - 0.017 14.9 3.9 0.49 10.2 0.1 2.8 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-BED PF02892.10 ESA24284.1 - 0.032 13.9 1.6 0.035 13.8 0.1 1.8 2 0 0 2 2 2 0 BED zinc finger SASRP1 PF15160.1 ESA24284.1 - 0.04 13.1 0.1 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 zf-C2H2_6 PF13912.1 ESA24284.1 - 0.045 13.6 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 ESA24284.1 - 4.3 7.7 7.1 0.94 9.8 2.0 2.0 2 0 0 2 2 2 0 Zinc-finger double domain Pkinase PF00069.20 ESA24285.1 - 1.5e-33 116.0 0.0 2.1e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24285.1 - 5.1e-31 107.6 0.0 6.5e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 ESA24285.1 - 0.0024 17.6 0.2 0.0037 17.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DASH_Duo1 PF08651.5 ESA24285.1 - 0.076 12.6 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 NST1 PF13945.1 ESA24287.1 - 1.6e-52 178.3 21.9 1.6e-52 178.3 15.2 7.0 4 2 1 5 5 5 2 Salt tolerance down-regulator UVR PF02151.14 ESA24290.1 - 0.00022 20.5 2.3 0.00023 20.5 0.1 2.1 2 0 0 2 2 2 1 UvrB/uvrC motif SPOUT_MTase_2 PF14419.1 ESA24290.1 - 0.0046 16.1 0.1 0.0063 15.7 0.1 1.2 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP DUF4363 PF14276.1 ESA24290.1 - 2.8 7.6 10.1 3.6 7.3 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) CPSF_A PF03178.10 ESA24291.1 - 2.9e-101 338.7 0.1 2.2e-98 329.2 0.0 2.7 3 0 0 3 3 3 2 CPSF A subunit region MMS1_N PF10433.4 ESA24291.1 - 3e-74 249.9 0.0 1.1e-73 248.1 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term YmzC PF14157.1 ESA24291.1 - 0.083 12.7 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 0 YmzC-like protein Coatomer_WDAD PF04053.9 ESA24291.1 - 0.21 10.3 0.0 1.8 7.2 0.0 2.1 2 0 0 2 2 2 0 Coatomer WD associated region Nop14 PF04147.7 ESA24293.1 - 0.48 8.2 3.7 0.54 8.1 2.6 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 ESA24293.1 - 2.6 7.2 9.0 3.5 6.8 6.2 1.1 1 0 0 1 1 1 0 SDA1 MtrF PF09472.5 ESA24294.1 - 0.057 12.6 0.0 0.14 11.3 0.0 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) EF-hand_1 PF00036.27 ESA24296.1 - 1.6e-42 139.5 14.4 2.2e-10 39.0 0.8 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 ESA24296.1 - 2.1e-38 130.2 4.4 2.4e-21 75.6 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 ESA24296.1 - 4e-33 112.8 12.0 2.7e-16 58.9 0.5 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 ESA24296.1 - 2.3e-31 104.8 7.2 1.8e-09 36.6 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 ESA24296.1 - 3e-28 95.8 8.2 3.1e-07 29.4 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 ESA24296.1 - 5.5e-16 58.2 0.2 3.8e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 ESA24296.1 - 3.3e-11 42.8 1.5 2.8e-05 23.7 0.2 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA24296.1 - 1.7e-09 37.6 0.0 0.00032 20.7 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 ESA24296.1 - 4.1e-07 29.5 1.6 0.18 11.4 0.0 4.0 4 1 1 5 5 5 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 ESA24296.1 - 1.3e-05 25.0 3.0 3.7e-05 23.6 0.3 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Caleosin PF05042.8 ESA24296.1 - 0.00044 19.8 0.2 0.08 12.4 0.0 2.6 1 1 1 3 3 3 1 Caleosin related protein EF-hand_like PF09279.6 ESA24296.1 - 0.00073 19.5 1.5 0.012 15.5 0.2 2.4 2 1 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like DUF1103 PF06513.6 ESA24296.1 - 0.00087 18.7 3.2 0.001 18.4 2.2 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) TerB PF05099.8 ESA24296.1 - 0.001 18.7 0.4 0.3 10.8 0.0 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB RNA_pol_Rpb4 PF03874.11 ESA24296.1 - 0.0089 16.0 1.4 1.7 8.6 0.1 2.6 3 0 0 3 3 3 1 RNA polymerase Rpb4 Poly_export PF02563.11 ESA24296.1 - 0.012 15.3 0.1 4 7.2 0.0 3.1 1 1 2 3 3 3 0 Polysaccharide biosynthesis/export protein Toprim_2 PF13155.1 ESA24296.1 - 0.017 15.4 1.3 3.5 8.0 0.8 2.6 1 1 1 2 2 2 0 Toprim-like Amdo_NSP PF12475.3 ESA24296.1 - 0.027 14.3 0.0 0.078 12.8 0.0 1.8 1 0 0 1 1 1 0 Amdovirus non-structural protein Tenui_NCP PF04876.7 ESA24296.1 - 0.03 13.8 0.2 0.64 9.5 0.0 2.1 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein LNS2 PF08235.8 ESA24296.1 - 0.045 13.3 0.0 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 LNS2 (Lipin/Ned1/Smp2) DUF1880 PF08976.6 ESA24296.1 - 0.057 13.5 0.0 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) SusE PF14292.1 ESA24296.1 - 0.058 13.2 0.5 0.32 10.8 0.0 2.1 2 0 0 2 2 2 0 SusE outer membrane protein DUF3650 PF12368.3 ESA24296.1 - 0.93 9.0 3.2 58 3.3 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3650) RloB PF13707.1 ESA24296.1 - 3.8 7.1 5.7 5.5 6.5 1.6 2.4 1 1 1 2 2 2 0 RloB-like protein Sel1 PF08238.7 ESA24297.1 - 1e-47 159.4 19.0 9.8e-09 35.5 0.0 8.1 7 0 0 7 7 7 6 Sel1 repeat DUF4244 PF14029.1 ESA24297.1 - 0.12 11.5 0.6 0.23 10.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Cyclin_N PF00134.18 ESA24298.1 - 1.4e-19 69.8 2.1 1.5e-19 69.7 0.8 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 ESA24298.1 - 3.2e-06 27.0 1.4 0.13 12.1 0.0 3.3 3 1 0 3 3 3 2 Cyclin, C-terminal domain TFIIB PF00382.14 ESA24298.1 - 0.00011 21.9 0.8 0.00057 19.6 0.0 2.3 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Spy1 PF11357.3 ESA24298.1 - 0.022 14.8 0.9 0.047 13.7 0.5 1.7 1 1 0 1 1 1 0 Cell cycle regulatory protein tRNA-synt_1c PF00749.16 ESA24299.1 - 8.3e-106 353.1 0.0 1.4e-105 352.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Arf PF00025.16 ESA24300.1 - 4.3e-78 260.5 0.0 4.9e-78 260.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 ESA24300.1 - 1.6e-13 50.3 0.0 1.7e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 ESA24300.1 - 6.2e-12 44.8 1.5 5.2e-08 31.9 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 ESA24300.1 - 1.1e-11 44.2 0.0 1.4e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 ESA24300.1 - 2.2e-10 40.0 0.0 2.6e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 ESA24300.1 - 6.4e-07 29.8 0.0 8.7e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 ESA24300.1 - 8e-05 22.5 0.1 0.00023 21.0 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.13 ESA24300.1 - 0.0022 17.1 0.1 0.0037 16.3 0.1 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase GTP_EFTU PF00009.22 ESA24300.1 - 0.01 15.3 0.0 0.055 12.8 0.0 1.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain E1_DerP2_DerF2 PF02221.10 ESA24301.1 - 9e-10 38.9 0.3 1.6e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 ML domain ASD1 PF08688.5 ESA24301.1 - 0.0076 16.0 0.4 0.011 15.5 0.3 1.4 1 0 0 1 1 1 1 Apx/Shroom domain ASD1 Myb_DNA-bind_4 PF13837.1 ESA24301.1 - 0.033 14.3 1.8 0.07 13.2 1.3 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Pkinase_Tyr PF07714.12 ESA24303.1 - 7.2e-07 28.5 0.0 7.8e-07 28.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24303.1 - 0.013 14.6 0.0 0.013 14.6 0.0 1.0 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 ESA24304.1 - 1.5e-16 60.2 0.0 2.1e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24304.1 - 1.6e-13 50.4 0.0 2.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-B_box PF00643.19 ESA24304.1 - 0.064 13.1 1.6 0.13 12.1 1.1 1.6 1 0 0 1 1 1 0 B-box zinc finger WaaY PF06176.6 ESA24304.1 - 0.077 12.2 0.1 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase_Tyr PF07714.12 ESA24305.1 - 9.7e-37 126.4 0.0 1.4e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 ESA24305.1 - 3.3e-28 98.5 0.0 5.8e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain E1-E2_ATPase PF00122.15 ESA24306.1 - 5.4e-58 195.7 5.9 5.4e-58 195.7 4.1 3.1 3 1 1 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.21 ESA24306.1 - 6e-27 95.4 0.1 1.3e-26 94.3 0.1 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 ESA24306.1 - 1.5e-13 51.3 0.0 3.5e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 ESA24306.1 - 5.5e-11 41.7 0.0 2.1e-10 39.9 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD_2 PF13419.1 ESA24306.1 - 0.096 12.9 0.0 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 ESA24306.1 - 0.21 11.1 0.0 0.21 11.1 0.0 3.6 4 0 0 4 4 4 0 haloacid dehalogenase-like hydrolase DLIC PF05783.6 ESA24307.1 - 1.2e-66 225.3 12.1 7.1e-52 176.6 0.1 4.0 3 1 0 3 3 3 3 Dynein light intermediate chain (DLIC) Miro PF08477.8 ESA24307.1 - 0.00074 20.0 0.1 0.0038 17.6 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 ESA24307.1 - 0.061 12.7 0.1 15 4.9 0.0 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 ESA24307.1 - 0.064 13.2 0.2 0.31 11.0 0.0 2.2 3 0 0 3 3 3 0 AAA ATPase domain MerB PF03243.10 ESA24308.1 - 0.00042 20.1 6.9 0.81 9.5 0.1 3.4 3 0 0 3 3 3 3 Alkylmercury lyase COP23 PF14218.1 ESA24308.1 - 0.0012 18.4 0.5 0.99 8.9 0.2 3.0 3 0 0 3 3 3 2 Circadian oscillating protein COP23 Fer4_7 PF12838.2 ESA24308.1 - 0.0014 19.0 1.0 11 6.4 0.0 3.4 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 ESA24308.1 - 0.022 15.0 8.2 8.9 6.6 0.3 3.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain Thioredoxin_3 PF13192.1 ESA24308.1 - 0.051 13.3 4.5 9.4 6.1 0.1 4.0 3 0 0 3 3 3 0 Thioredoxin domain Fer4_4 PF12800.2 ESA24308.1 - 8.3 7.0 11.0 18 6.0 0.2 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain DDE_3 PF13358.1 ESA24309.1 - 1.1e-18 67.4 0.0 2e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF1289 PF06945.8 ESA24309.1 - 0.017 14.5 0.0 0.3 10.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) HeH PF12949.2 ESA24309.1 - 0.02 14.4 0.4 0.68 9.5 0.0 2.7 1 1 1 2 2 2 0 HeH/LEM domain EF-hand_1 PF00036.27 ESA24310.1 - 3.1e-21 72.9 24.6 8.8e-05 21.5 0.9 7.6 7 0 0 7 7 7 5 EF hand EF-hand_6 PF13405.1 ESA24310.1 - 8.2e-20 68.8 19.0 0.0032 17.2 0.5 7.6 8 0 0 8 8 8 5 EF-hand domain EF-hand_7 PF13499.1 ESA24310.1 - 3.3e-19 68.7 16.9 5.5e-07 29.6 1.1 4.5 2 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 ESA24310.1 - 3.6e-15 54.5 19.4 0.0012 18.1 0.0 5.9 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 ESA24310.1 - 1.2e-12 47.2 15.7 0.00013 21.4 0.5 5.7 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_4 PF12763.2 ESA24310.1 - 2.1e-09 37.0 6.0 0.025 14.2 0.1 5.1 2 2 3 5 5 5 4 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 ESA24310.1 - 8e-05 22.6 2.6 0.0078 16.2 0.0 3.7 3 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region B12D PF06522.6 ESA24311.1 - 1.4e-18 66.3 0.3 1.9e-18 65.9 0.2 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF677 PF05055.7 ESA24315.1 - 0.0044 15.7 7.5 0.0056 15.4 3.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF677) Med9 PF07544.8 ESA24315.1 - 0.013 15.1 2.9 0.013 15.1 2.0 3.9 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Pox_A_type_inc PF04508.7 ESA24315.1 - 0.018 14.7 2.3 0.018 14.7 1.6 6.2 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat FlaC_arch PF05377.6 ESA24315.1 - 0.13 12.1 10.4 2.6 8.0 0.7 4.5 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 ESA24315.1 - 0.16 11.1 2.4 2.8 7.0 0.5 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein APG6 PF04111.7 ESA24315.1 - 2.3 7.1 25.2 0.36 9.8 3.9 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 DUF1664 PF07889.7 ESA24315.1 - 5.1 6.9 13.8 11 5.8 0.0 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.4 ESA24315.1 - 5.4 6.8 25.9 2.2 8.1 0.0 3.9 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.6 ESA24315.1 - 6.6 6.6 11.0 6.5 6.6 0.7 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Sel1 PF08238.7 ESA24319.1 - 5.5e-43 144.4 11.5 2.1e-08 34.5 0.0 6.3 5 1 1 6 6 6 5 Sel1 repeat SPRY PF00622.23 ESA24319.1 - 4.1e-09 36.5 0.3 1.3e-08 34.9 0.2 1.9 2 0 0 2 2 2 1 SPRY domain BTB PF00651.26 ESA24319.1 - 5.3e-05 23.1 0.6 0.00012 22.0 0.4 1.7 1 0 0 1 1 1 1 BTB/POZ domain MIT PF04212.13 ESA24319.1 - 0.00014 21.6 13.9 0.93 9.4 0.3 5.2 4 1 1 5 5 5 4 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 ESA24319.1 - 3.1 7.4 16.4 2.8 7.6 0.5 4.6 2 2 1 3 3 3 0 TPR repeat EF-hand_1 PF00036.27 ESA24321.1 - 4.5e-20 69.3 13.5 2.2e-07 29.6 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 ESA24321.1 - 2.3e-17 61.2 14.2 1.2e-06 27.8 0.1 4.4 5 0 0 5 5 4 3 EF-hand domain EF-hand_8 PF13833.1 ESA24321.1 - 3.9e-16 58.3 11.1 3.5e-11 42.5 0.6 3.6 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 ESA24321.1 - 8e-16 57.9 11.2 7.1e-10 38.8 4.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 ESA24321.1 - 1.4e-11 43.1 12.1 0.00079 18.6 0.8 3.6 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.1 ESA24321.1 - 3.3e-10 39.7 0.3 0.00016 21.5 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain Ribosomal_L11 PF00298.14 ESA24321.1 - 0.0016 18.4 3.5 0.59 10.3 0.0 3.0 3 0 0 3 3 3 2 Ribosomal protein L11, RNA binding domain EF-hand_10 PF14788.1 ESA24321.1 - 0.0056 16.3 6.9 0.0082 15.7 0.5 3.0 3 1 0 3 3 3 1 EF hand EF-hand_4 PF12763.2 ESA24321.1 - 0.011 15.4 10.3 0.56 9.9 1.9 3.5 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand REC114-like PF15165.1 ESA24321.1 - 0.019 14.6 0.2 0.025 14.3 0.1 1.3 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like Pex14_N PF04695.8 ESA24321.1 - 0.6 10.1 6.0 5.2 7.1 1.7 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPARC_Ca_bdg PF10591.4 ESA24321.1 - 0.78 9.7 4.8 13 5.8 1.2 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DAG_kinase_N PF14513.1 ESA24321.1 - 1.3 9.2 5.9 0.21 11.8 0.2 2.1 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Tubulin_3 PF14881.1 ESA24321.1 - 6.9 6.0 6.5 0.53 9.7 0.8 1.7 2 0 0 2 2 2 0 Tubulin domain zf-CCHC PF00098.18 ESA24322.1 - 0.00011 21.9 0.6 0.00019 21.2 0.4 1.4 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.12 ESA24322.1 - 0.0019 18.2 0.0 0.0049 16.8 0.0 1.7 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC_3 PF13917.1 ESA24322.1 - 0.019 14.6 0.0 0.045 13.4 0.0 1.7 1 0 0 1 1 1 0 Zinc knuckle UBN2 PF14223.1 ESA24322.1 - 0.027 14.2 0.0 0.089 12.5 0.0 1.9 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type DUF4200 PF13863.1 ESA24322.1 - 1.4 8.8 4.4 25 4.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DDE_1 PF03184.14 ESA24323.1 - 1.5e-39 135.4 1.9 9.6e-35 119.6 0.6 2.7 1 1 2 3 3 3 2 DDE superfamily endonuclease CENP-B_N PF04218.8 ESA24323.1 - 2e-10 39.8 1.0 4.4e-10 38.8 0.7 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.11 ESA24323.1 - 4.7e-09 35.9 0.1 1.1e-08 34.7 0.1 1.7 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.1 ESA24323.1 - 0.0073 16.0 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_4 PF13613.1 ESA24323.1 - 0.019 14.4 0.0 0.16 11.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease HTH_24 PF13412.1 ESA24323.1 - 0.025 13.9 0.4 0.1 12.0 0.2 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding dTMP_synthase PF02593.9 ESA24323.1 - 0.064 12.5 0.5 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Thymidylate synthase HTH_Tnp_ISL3 PF13542.1 ESA24323.1 - 0.067 12.3 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 DUF1722 PF08349.6 ESA24324.1 - 0.098 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) PHA_synth_III_E PF09712.5 ESA24325.1 - 0.01 15.2 0.0 0.012 15.0 0.0 1.1 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) ALS_ss_C PF10369.4 ESA24325.1 - 0.026 14.2 0.1 1.2 8.9 0.0 2.2 1 1 1 2 2 2 0 Small subunit of acetolactate synthase DUF3620 PF12281.3 ESA24325.1 - 0.032 13.9 0.1 0.041 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3620) She9_MDM33 PF05546.6 ESA24325.1 - 0.067 12.7 3.9 0.089 12.3 2.7 1.2 1 0 0 1 1 1 0 She9 / Mdm33 family TetR_C PF02909.12 ESA24325.1 - 0.092 12.3 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Tetracyclin repressor, C-terminal all-alpha domain Fib_alpha PF08702.5 ESA24325.1 - 0.096 12.8 4.6 0.12 12.5 3.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family NAAA-beta PF15508.1 ESA24325.1 - 0.12 12.7 0.3 0.23 11.8 0.2 1.6 1 1 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Enkurin PF13864.1 ESA24326.1 - 0.015 15.4 4.6 0.041 14.0 3.2 1.8 1 1 0 1 1 1 0 Calmodulin-binding Rop-like PF05082.8 ESA24326.1 - 0.027 13.9 1.9 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Rop-like DUF4391 PF14335.1 ESA24326.1 - 0.04 13.3 3.0 0.073 12.4 2.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4391) zf-C4H2 PF10146.4 ESA24326.1 - 0.04 13.9 4.4 0.03 14.3 1.9 1.6 1 1 1 2 2 2 0 Zinc finger-containing protein Seryl_tRNA_N PF02403.17 ESA24326.1 - 0.049 13.6 8.5 1 9.4 2.5 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlgN PF05130.7 ESA24326.1 - 0.054 13.7 2.4 0.075 13.2 1.7 1.3 1 1 0 1 1 1 0 FlgN protein DivIC PF04977.10 ESA24326.1 - 0.062 12.7 4.6 0.29 10.6 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator WD40_alt PF14077.1 ESA24326.1 - 0.072 12.7 2.2 6.9 6.3 0.1 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif AHSP PF09236.5 ESA24326.1 - 0.11 12.6 1.0 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein DUF4140 PF13600.1 ESA24326.1 - 0.13 12.6 4.3 0.13 12.6 1.5 1.9 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.5 ESA24326.1 - 0.16 12.1 3.3 0.2 11.7 2.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PNPase PF03726.9 ESA24326.1 - 0.16 12.2 2.0 1 9.6 1.4 2.4 1 1 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DivIVA PF05103.8 ESA24326.1 - 0.19 11.7 7.0 0.36 10.8 4.8 1.4 1 1 0 1 1 1 0 DivIVA protein UPF0242 PF06785.6 ESA24326.1 - 0.27 9.8 3.4 0.31 9.6 2.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Vmethyltransf_C PF08456.5 ESA24326.1 - 0.27 10.6 4.4 0.53 9.6 3.0 1.5 1 1 0 1 1 1 0 Viral methyltransferase C-terminal FliD_N PF02465.13 ESA24326.1 - 0.28 11.5 5.1 6.5 7.1 0.1 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF2130 PF09903.4 ESA24326.1 - 0.3 9.7 7.7 0.99 8.0 0.2 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) Syntaxin-6_N PF09177.6 ESA24326.1 - 0.34 11.3 4.7 4.6 7.7 3.3 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TipAS PF07739.8 ESA24326.1 - 0.37 11.1 2.8 0.86 9.9 0.2 2.0 1 1 0 2 2 2 0 TipAS antibiotic-recognition domain DUF1043 PF06295.7 ESA24326.1 - 0.37 10.4 2.8 0.69 9.5 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Mnd1 PF03962.10 ESA24326.1 - 0.38 10.4 7.5 2 8.0 5.2 2.0 1 1 0 1 1 1 0 Mnd1 family COG5 PF10392.4 ESA24326.1 - 0.38 10.7 4.5 1.5 8.8 1.3 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 CENP-Q PF13094.1 ESA24326.1 - 0.53 10.3 7.4 3.6 7.6 4.4 1.9 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FlaC_arch PF05377.6 ESA24326.1 - 0.68 9.8 3.8 0.99 9.3 0.1 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) IncA PF04156.9 ESA24326.1 - 0.76 9.3 10.1 11 5.5 6.5 2.0 1 1 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 ESA24326.1 - 0.94 9.4 8.5 0.27 11.2 2.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF972 PF06156.8 ESA24326.1 - 1.6 9.1 5.7 13 6.2 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Prefoldin PF02996.12 ESA24326.1 - 1.6 8.3 6.4 7.4 6.2 0.3 2.2 2 0 0 2 2 2 0 Prefoldin subunit ADIP PF11559.3 ESA24326.1 - 1.8 8.4 8.8 0.64 9.9 2.6 2.0 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Kinetocho_Slk19 PF12709.2 ESA24326.1 - 3.9 7.6 8.2 12 6.1 0.6 2.3 1 1 0 2 2 2 0 Central kinetochore-associated Sec5 PF15469.1 ESA24327.1 - 0.036 13.7 0.1 0.053 13.2 0.1 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5